Sample records for multiple indicators multiple

  1. Multiple indicators, multiple causes measurement error models.

    PubMed

    Tekwe, Carmen D; Carter, Randy L; Cullings, Harry M; Carroll, Raymond J

    2014-11-10

    Multiple indicators, multiple causes (MIMIC) models are often employed by researchers studying the effects of an unobservable latent variable on a set of outcomes, when causes of the latent variable are observed. There are times, however, when the causes of the latent variable are not observed because measurements of the causal variable are contaminated by measurement error. The objectives of this paper are as follows: (i) to develop a novel model by extending the classical linear MIMIC model to allow both Berkson and classical measurement errors, defining the MIMIC measurement error (MIMIC ME) model; (ii) to develop likelihood-based estimation methods for the MIMIC ME model; and (iii) to apply the newly defined MIMIC ME model to atomic bomb survivor data to study the impact of dyslipidemia and radiation dose on the physical manifestations of dyslipidemia. As a by-product of our work, we also obtain a data-driven estimate of the variance of the classical measurement error associated with an estimate of the amount of radiation dose received by atomic bomb survivors at the time of their exposure. PMID:24962535

  2. Multiplication

    NSDL National Science Digital Library

    Ms.Roberts

    2009-02-24

    How sharp are your multiplication skills? Give these great math games a try ! Play Asteroids blaster and test your multiplication skills. How fast can you solve the problem... play a round of Baseball multiplication and see! Multiplication is fun and delicious with Crazy Cones. Help Lemonade Larry determine the correct amount! Test your multiplication skills with Tic Tac Toe! ...

  3. Multiplication

    NSDL National Science Digital Library

    Ms. Walker

    2008-03-26

    Here are some fun games to make practicing multiplication fun!!! Before you start the fun... click Multiplication Tables to review what you already know! Can you figure out the Multiplication Hidden Picture... you better know your math skills first or the picture will burst! It\\'s times to have a \\"blast\\"... Blow me away with theMultiplication Tunnel Blaster Now your ready to join the team! Show me ...

  4. Multiple Indicator Stationary Time Series Models.

    ERIC Educational Resources Information Center

    Sivo, Stephen A.

    2001-01-01

    Discusses the propriety and practical advantages of specifying multivariate time series models in the context of structural equation modeling for time series and longitudinal panel data. For time series data, the multiple indicator model specification improves on classical time series analysis. For panel data, the multiple indicator model…

  5. Multiplication

    NSDL National Science Digital Library

    Ms. Williams

    2011-04-06

    Which way of learning multiplication helped you the best? First you will need to use organizer Then you need to go to thinking blocks Next go to multiplication rap song Then go to dinosaur game and times table and lattice method and finally flashcards after this look over your graphic organizer and think about which site was most helpful for you. You will then be divided into groups where you will make your own creative lesson ...

  6. Should researchers use single indicators, best indicators, or multiple indicators in structural equation models?

    PubMed Central

    2012-01-01

    Background Structural equation modeling developed as a statistical melding of path analysis and factor analysis that obscured a fundamental tension between a factor preference for multiple indicators and path modeling’s openness to fewer indicators. Discussion Multiple indicators hamper theory by unnecessarily restricting the number of modeled latents. Using the few best indicators – possibly even the single best indicator of each latent – encourages development of theoretically sophisticated models. Additional latent variables permit stronger statistical control of potential confounders, and encourage detailed investigation of mediating causal mechanisms. Summary We recommend the use of the few best indicators. One or two indicators are often sufficient, but three indicators may occasionally be helpful. More than three indicators are rarely warranted because additional redundant indicators provide less research benefit than single indicators of additional latent variables. Scales created from multiple indicators can introduce additional problems, and are prone to being less desirable than either single or multiple indicators. PMID:23088287

  7. Differential Item Functioning Detection Using the Multiple Indicators, Multiple Causes Method with a Pure Short Anchor

    ERIC Educational Resources Information Center

    Shih, Ching-Lin; Wang, Wen-Chung

    2009-01-01

    The multiple indicators, multiple causes (MIMIC) method with a pure short anchor was proposed to detect differential item functioning (DIF). A simulation study showed that the MIMIC method with an anchor of 1, 2, 4, or 10 DIF-free items yielded a well-controlled Type I error rate even when such tests contained as many as 40% DIF items. In general,…

  8. Constrained multiple indicator kriging using sequential quadratic programming

    NASA Astrophysics Data System (ADS)

    Soltani-Mohammadi, Saeed; Erhan Tercan, A.

    2012-11-01

    Multiple indicator kriging (MIK) is a nonparametric method used to estimate conditional cumulative distribution functions (CCDF). Indicator estimates produced by MIK may not satisfy the order relations of a valid CCDF which is ordered and bounded between 0 and 1. In this paper a new method has been presented that guarantees the order relations of the cumulative distribution functions estimated by multiple indicator kriging. The method is based on minimizing the sum of kriging variances for each cutoff under unbiasedness and order relations constraints and solving constrained indicator kriging system by sequential quadratic programming. A computer code is written in the Matlab environment to implement the developed algorithm and the method is applied to the thickness data.

  9. Multiple-Indicator Multilevel Growth Model: A Solution to Multiple Methodological Challenges in Longitudinal Studies

    Microsoft Academic Search

    Amery D. Wu; Yan Liu; Anne M. Gadermann; Bruno D. Zumbo

    2010-01-01

    This paper described the versatility of the multiple-indicator multilevel (MIML) model in helping to resolve four common challenges\\u000a in studying growth using longitudinal data. These challenges are (1) how to deal with changes in measurement over time and\\u000a investigate temporal measurement invariance, (2) how to model residual dependence due to the nested nature of longitudinal\\u000a data, (3) how to model

  10. Multiple-input Multiple-output Ground Moving Target Indicator Radar: Theory and Practice

    NASA Astrophysics Data System (ADS)

    Bliss, Dan

    2012-02-01

    Multiple-input multiple-output (MIMO) extensions to radar systems enable a number of advantages compared to traditional approaches. These advantages include improved angle estimation and target detection. In this paper, an overview of MIMO radar is provided, and the concept of coherent MIMO radar is defined. The principle focus of the paper is the discussion of MIMO ground moving target indication (GMTI). For GMTI radar modes, the advantages of a coherent MIMO architecture include improved angle estimation and enhanced slow speed target detection. To illustrate this, the concept of coherent MIMO radar is introduced and performance comparisons made between MIMO GMTI and traditional radar GMTI. These comparisons are supported by theoretical bounds, simulations, and experimental results for GMTI angle estimation accuracy and minimum detectable target velocity. For some applications, these results indicate significant potential improvements in clutter-mitigation, signal-to-noise ratio (SNR) loss, and reduction in angle-estimation error for slow-moving targets. The important effects of waveform characteristics is addressed.

  11. Indicators of Multiplicative Reasoning among Fourth Grade Students

    ERIC Educational Resources Information Center

    Carrier, James A.

    2010-01-01

    Many students encounter difficulty in their transition to advanced mathematical thinking. Such difficulty may be explained by a lack of understanding of many concepts taught in early school years, especially multiplicative reasoning. Advanced mathematical thinking depends on the development of multiplicative reasoning. The purpose of this study…

  12. A multiple indicator, multiple cause method for representing social capital with an application to psychological distress

    NASA Astrophysics Data System (ADS)

    Congdon, Peter

    2010-03-01

    This paper describes a structural equation methodology for obtaining social capital scores for survey subjects from multiple indicators of social support, neighbourhood and trust perceptions, and memberships of organizations. It adjusts for variation that is likely to occur in levels of social capital according to geographic context (e.g. level of area deprivation, geographic region, level of urbanity) and demographic group. Social capital is used as an explanatory factor for psychological distress using data from the 2006 Health Survey for England. A highly significant effect of social capital in reducing the chance of psychiatric caseness is obtained after controlling for other individual and geographic risk factors. Allowing for social capital has considerable effects on the impacts on psychiatric health of other risk factors. In particular, the impact of area deprivation category is much reduced. There is also evidence of significant differentiation in social capital between population categories and geographic contexts.

  13. Prognostic indicators of lenalidomide for multiple myeloma: consensus and controversy.

    PubMed

    Kuroda, Junya; Kobayashi, Tsutomu; Taniwaki, Masafumi

    2015-07-01

    The long-term outcome of multiple myeloma (MM) has been greatly improved through new agents, one being lenalidomide (LEN). Based upon the findings of in vitro experiments, its mode of action against MM occurs through a combination of direct tumoricidal effects on myeloma cells, modulatory effects on tumor immunity and tumor microenvironment-regulatory effects. However, it has not been clearly defined whether the clinical response and long-term outcome of MM with LEN treatment truly reflect the mechanisms of action of LEN proposed by in vitro studies. To ascertain what is known and what remains to be elucidated with LEN, we review the current literature on the mode of action of LEN in association with myeloma pathophysiology, and discuss the prognostic indicators in the treatment of MM with LEN. PMID:25947283

  14. Indicators of Multiple Personality Disorder for the Clinician.

    ERIC Educational Resources Information Center

    Dalton, Thomas W.

    Multiple personality disorder (MPD) is now recognized as a valid diagnostic category. Occurrence may be higher than previously suspected. While physiological testing of MPD has shown significant differences between the various personalities of individuals in terms of galvanic skin response, electroencephalogram recordings, electrodermal response…

  15. Multiple uses of indicators and indices in cumulative effects assessment and management

    SciTech Connect

    Canter, L.W., E-mail: envimptr@aol.com [University of Oklahoma and Environmental Impact Training, Horseshoe Bay, TX (United States); Atkinson, S.F. [Institute of Applied Science, University of North Texas, Denton, TX (United States)

    2011-09-15

    Both environmental indicators and multi-metric indices are useful for describing baseline conditions and qualitatively predicting the cumulative consequences of multiple actions. Several examples and case studies associated with indicators and/or indices are presented herein. They can be easily modified for usage in CEAM. Habitat suitability models reflect special indices related to habitat needs and quality for specific species or broad habitat types. Such models have been used to address direct and indirect effects, and with some modification, they can be also used to address cumulative effects of multiple actions. This review has indicated that there are numerous examples of such tools which have been or could be used in both EIA and CEAM. Some key lessons are: (1) in conducting CEAM studies, it is useful to think from the mindset that 'I am the VEC or indicator, and what is my historical and current condition and how have I, or will I, be affected by multiple past, present, and future actions?'; (2) due to the likely absence of detailed information on future actions, the described tools can still be used to 'predict' future conditions by focusing on qualitative up-or-down changes in individual indicators or indices with their aggregated displays; and (3) numerous regional and site-specific tools are currently available, with one example being indices of biological integrity for specific watersheds and water bodies. Such tools, even though they may not have been developed for CEAM usage, can certainly benefit CEAM studies and practice. Finally, usage of selected and appropriate tools as described herein can aid in conducting science-based, systematic, and documentable CEAM studies.

  16. Iran's Multiple Indicator Demographic and Health Survey - 2010: Study Protocol

    PubMed Central

    Rashidian, Arash; Karimi-Shahanjarini, Akram; Khosravi, Ardeshir; Elahi, Elham; Beheshtian, Maryam; Shakibazadeh, Elham; Khabiri, Roghayeh; Arab, Mohammad; Zakeri, Mohammad-Reza

    2014-01-01

    Background: There is an international emphasis on providing timely and high quality data to monitor progress of countries toward Millennium Development Goals. Iran's Multiple Indicator Demographic and Health Survey (IrMIDHS) aimed to provide valid information on population and health outcomes to monitor progress in achieving national priorities and health programs and to assist policy makers to design effective strategies for improving health outcomes and equity in access to care. Methods: A cross-sectional multi-stage stratified cluster-random survey is conducted through face-to-face household interviews. The sampling frame is developed using Iran's 2006 population and housing census. Provincial samples ranging are from a minimum of 400 households per province to 6400 households in Tehran province. Cluster size is 10 households. The target sample includes 3096 clusters: 2187 clusters in urban and 909 clusters in rural areas. IrMIDHS instruments include three questionnaires: Household questionnaire, women aged 15-54 questionnaire, children under five questionnaire, supervision and quality assessment checklists and data collection sheets and standard weight and height measurement tools for under-five children. A cascading decentralized training method is used for training data collection and supervision teams. Quality assurance procedures are defined for the five steps of conducting the survey including: Sampling, training data collection and training teams, survey implementation, data entry and analysis. A multi-layer supervision and monitoring procedure is established. All the questionnaires are double entered. Conclusions: IrMIDHS will provide valuable data for policymakers in Iran. Designing and implementation of the study involve contributions from academics as well as program managers and policy makers. The collaborative nature of the study may facilitate better usage of its results. PMID:24932396

  17. MUPEMURE Multiple Perspectives on Multiple

    E-print Network

    Paris-Sud XI, Université de

    MUPEMURE ­ Multiple Perspectives on Multiple Representations White Paper Organizers: The MUPEMURE-00722956,version1-6Aug2012 #12; MUPEMURE ­ Multiple Perspectives on Multiple Representations Seite 1 MUPEMURE ­ Multiple Perspectives on Multiple Representations White Paper 1. Introduction and Motivation Our

  18. Learning about Locomotion Patterns: Effective Use of Multiple Pictures and Motion-Indicating Arrows

    ERIC Educational Resources Information Center

    Imhof, Birgit; Scheiter, Katharina; Edelmann, Jorg; Gerjets, Peter

    2013-01-01

    This study investigated how enriching visualizations with arrows indicating the motion of objects may help in conveying dynamic information: Multiple static-simultaneous visualizations with motion-indicating arrows were compared with either multiple visualizations without arrows or a single visualization with arrows. Seventy-one students were…

  19. Watermarking Multiple Constant Multiplications Solutions

    E-print Network

    Wong, Jennifer L.

    Watermarking Multiple Constant Multiplications Solutions Jennifer L. Wong, Ji-Qing Ya, Miodrag Potkonjak University of California, Los Angeles, CA 90095 Abstract-- Multiplications and multipliers these requirements is to use combinations of shifts and additions to execute multiplications. The approach

  20. Relations between virtues and positive mental health in a Korean population: A Multiple Indicators Multiple Causes (MIMIC) model approach.

    PubMed

    Lim, Young-Jin

    2015-08-01

    A Multiple Indicators Multiple Causes (MIMIC) approach was applied to investigate the relationship between virtues and positive mental health as determined using the Character Strength Test and the Mental Health Continuum-Short Form. The study participants were 876 college students (54% women; overall mean age [SD] 21.50 years [2.35]) recruited from introductory psychology courses at two universities in Seoul. Findings revealed that the intellectual virtues of college students predicted subjective well-being according to all emotional, social and psychological measures. Results are discussed in the context of previous work using the Values in Action classification of virtues and character strengths. In addition, implications regarding understanding the nature and possible origins of positive mental health are outlined. PMID:25130769

  1. Identifying indicators of laboratory management performance: a multiple constituency approach.

    PubMed

    Zinn, J; Zalokowski, A; Hunter, L

    2001-01-01

    The challenges for laboratory management posed by cost control, managed care, organizational restructuring, information networking and health system integration call for new measures to evaluate how effectively laboratories manage emerging performance expectations. This study identifies the Delphi panel method in achieving consensus on measures of effectiveness and considers a specific application, the identification of indicators of laboratory performance, from the perspective of key constituencies. PMID:11233353

  2. Multiplication 2

    NSDL National Science Digital Library

    Miss Lerdahl

    2010-11-16

    Try some harder multiplication activities! Missing Factor Meteor Blasting Complete the Missing Step Batter s Up Multiplication Sum Sense Multiplication Challenge a Friend to Grand Prix Multiplication Double Digit Multiplication https://embed.espresso.co.uk/espresso/embed/images/logo_espresso.gif ) no-repeat center center" Multiplication Fun

    NSDL National Science Digital Library

    Mrs. Young

    2007-10-25

    Play to following games to pracitce your muliplicaiton tables. Hit a Home Run! Start with Multiplication Baseball (Easy). Once your have beat this team try to beat Multiplication Baseball (Medium). When you beat the first two teams try to beat this challanging team Multiplication Baseball (Hard) Learn your multiplication facts by playing Multiplication Flash Fun ...

  3. Multiplication table

    NSDL National Science Digital Library

    bgross

    2011-04-14

    Help learn First learn go over your Learn The Multiplication table now get some extra help Learn The Multiplication table have fun Learn The multiplication table with games good luck practice test pre test pre test final test ...

  4. Mastering Multiplication

    NSDL National Science Digital Library

    Ms. Jackson

    2007-10-25

    Play the following games to practice your multiplication. Take a swing at Multplication Baseball! (Set with hard) Use your multiplication knowledge and defeat the Mayan Math Monster! (Set to hard) Quick! Stop the Multiplication Invader before it is too late! ...

  5. Multiplication Rocks!!!

    NSDL National Science Digital Library

    Mrs. Peake

    2009-04-15

    Let's practice what we've learned about multiplication. Play at least one game in each of the categories. Times Table Practice: Design the Ultimate Fashion Outfit with Math Models Blast the Meteors before they destroy the ship in Meteor Multiplication More Multiplication: Batter's Up in Baseball Multiplication Win $1,000,000 in Who Wants To Be A Millionaire? ...

  6. Multiplication World

    NSDL National Science Digital Library

    Mrs. Crawford

    2007-10-25

    We will use the following games to practice and sharpen our multiplication skills. First, lets use Sum Sense Multiplication to sharpen our skills. Next we will engage in Memory Madness for Multiplication. I have a question for the class now... is this Too much multiplication to guess?. ...

  7. Multiplication Maddness!

    NSDL National Science Digital Library

    Ms. Morgan

    2008-04-03

    Review your multiplication skills with these fun and exciting games! To excercise your brain, start with a review of your multiplication facts with Matching Multiplication! Step up to the plate and use your best swing! It\\'s time to play Batter s Up Baseball! Battle through the multiplication problems to save the princess. Begin your journey of Castle Quest! ...

  8. Single and Multiple Indicators of Physical Attractiveness and Psychosocial Behaviors among Young Adolescents.

    ERIC Educational Resources Information Center

    Perkins, Daniel F.; Lerner, Richard M.

    1995-01-01

    Examined relations among several indicators of physical attractiveness (PA): height, weight, and triceps skinfold thickness. Appraised whether multiple PA indicators accounted for more variation in measures of psychosocial functioning than did single PA indexes. Facial attractiveness was the most frequent statistically significant predictor of…

  9. Control, compare and communicate: designing control charts to summarise efficiently data from multiple quality indicators

    Microsoft Academic Search

    B Guthrie; T Love; T Fahey; A Morris; F Sullivan

    2005-01-01

    Summarising the complex data generated by multiple cross sectional quality indicators in a way that patients, clinicians, managers and policymakers find useful is challenging. A common approach is aggregation to create summary measures such as star ratings and balanced score cards, but these may conceal the detail needed to focus quality improvement. We propose an alternative way of summarising and

  10. Gender and Perceived Illness Severity: Differential Indicators of Employment Concerns for Adults with Multiple Sclerosis?

    ERIC Educational Resources Information Center

    Roessler, Richard T.; Turner, Ronna C.; Robertson, Judith L.; Rumrill,Phillip D.

    2005-01-01

    Although research has indicated a link between gender and perceived illness severity and the employment status of people with multiple sclerosis (MS), it has not addressed questions regarding the relationship between those variables and specific types of employment concerns. In this study, a sample of 1,310 adults with MS replied to a mail survey…

  11. Multiple Sclerosis

    MedlinePLUS

    Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the ... attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins ...

  12. Applying a Multiple Group Causal Indicator Modeling Framework to the Reading Comprehension Skills of Third, Seventh, and Tenth Grade Students

    ERIC Educational Resources Information Center

    Tighe, Elizabeth L.; Wagner, Richard K.; Schatschneider, Christopher

    2015-01-01

    This study demonstrates the utility of applying a causal indicator modeling framework to investigate important predictors of reading comprehension in third, seventh, and tenth grade students. The results indicated that a 4-factor multiple indicator multiple indicator cause (MIMIC) model of reading comprehension provided adequate fit at each grade…

  13. UNAIDS 'multiple sexual partners' core indicator: promoting sexual networks to reduce potential biases.

    PubMed

    Dimbuene, Zacharie Tsala; Emina, Jacques B O; Sankoh, Osman

    2014-01-01

    UNAIDS proposed a set of core indicators for monitoring changes in the worldwide AIDS epidemic. This paper explores the validity and effectiveness of the 'multiple sexual partners' core indicator, which is only partially captured with current available data. The paper also suggests an innovative approach for collecting more informative data that can be used to provide an accurate measure of the UNAIDS's 'multiple sexual partners' core indicator. Specifically, the paper addresses three major limitations associated with the indicator when it is measured with respondents' sexual behaviors. First, the indicator assumes that a person's risk of contracting HIV/AIDS/STIs is merely a function of his/her own sexual behavior. Second, the indicator does not account for a partner's sexual history, which is very important in assessing an individual's risk level. Finally, the 12-month period used to define a person's risks can be misleading, especially because HIV/AIDS theoretically has a period of latency longer than a year. The paper concludes that, programmatically, improvements in data collection are a top priority for reducing the observed bias in the 'multiple sexual partners' core indicator. PMID:24647127

  14. UNAIDS ‘multiple sexual partners’ core indicator: promoting sexual networks to reduce potential biases

    PubMed Central

    Dimbuene, Zacharie Tsala; Emina, Jacques B.O.; Sankoh, Osman

    2014-01-01

    UNAIDS proposed a set of core indicators for monitoring changes in the worldwide AIDS epidemic. This paper explores the validity and effectiveness of the ‘multiple sexual partners’ core indicator, which is only partially captured with current available data. The paper also suggests an innovative approach for collecting more informative data that can be used to provide an accurate measure of the UNAIDS’s ‘multiple sexual partners’ core indicator. Specifically, the paper addresses three major limitations associated with the indicator when it is measured with respondents’ sexual behaviors. First, the indicator assumes that a person’s risk of contracting HIV/AIDS/STIs is merely a function of his/her own sexual behavior. Second, the indicator does not account for a partner’s sexual history, which is very important in assessing an individual’s risk level. Finally, the 12-month period used to define a person’s risks can be misleading, especially because HIV/AIDS theoretically has a period of latency longer than a year. The paper concludes that, programmatically, improvements in data collection are a top priority for reducing the observed bias in the ‘multiple sexual partners’ core indicator. PMID:24647127

  15. Finger Multiplication

    ERIC Educational Resources Information Center

    Simanihuruk, Mudin

    2011-01-01

    Multiplication facts are difficult to teach. Therefore many researchers have put a great deal of effort into finding multiplication strategies. Sherin and Fuson (2005) provided a good survey paper on the multiplication strategies research area. Kolpas (2002), Rendtorff (1908), Dabell (2001), Musser (1966) and Markarian (2009) proposed the finger…

  16. Multiplication Rocks!

    NSDL National Science Digital Library

    Mrs. Hyde

    2006-10-26

    Play these three games to practice your multiplication facts and have fun. Who Want\\'s to be a Mathionaire? Who Want s to be a Mathionaire? Play Multiplication Matho three times and see if you can get less errors every time. Multiplication Matho Play Lemonade Larry three times. Lemonade Larry (Math) ...

  17. Multiple Correlation versus Multiple Regression.

    ERIC Educational Resources Information Center

    Huberty, Carl J.

    2003-01-01

    Describes differences between multiple correlation analysis (MCA) and multiple regression analysis (MRA), showing how these approaches involve different research questions and study designs, different inferential approaches, different analysis strategies, and different reported information. (SLD)

  18. Multiple indicator hidden Markov model with an application to medical utilization data

    PubMed Central

    Wall, Melanie M.; Li, Ran

    2009-01-01

    Monthly counts of medical visits across several years for persons identified to have alcoholism problems are modeled using two-state hidden Markov models (HMM) in order to describe the effect of alcoholism treatment on the likelihood of persons to be in a “healthy” or “unhealthy” state. The medical visits can be classified into different types leading to multivariate counts of medical visits each month. A multiple indicator hidden Markov model is introduced that simultaneously fits the multivariate Poisson counts by assuming a shared hidden state underlying all of them. The multiple indicator hidden Markov model borrows information across different types of medical encounters. A univariate HMMs based on the total count across types of medical visits each month is also considered. Comparisons between the multiple indicator HMM and the total count HMM are made, as well as comparisons with more traditional longitudinal models that directly model the counts. A Bayesian framework is used for estimation of the HMM and implementation is in Winbugs. PMID:18991318

  19. Multiple Trichofolliculomas Mimicking Multiple Trichoepitheliomas

    PubMed Central

    Nayak, Sudhir UK; Shenoi, Shrutakirthi D; Geetha, V; Prabhu, Smitha; Nagel, Bhawna

    2015-01-01

    Trichofolliculomas are benign hair follicle hamartomas which were initially considered as hair follicle tumors. Usually presenting as a solitary lesion associated with a tuft of vellus hairs, multiple trichofolliculomas are rare. Trichofolliculomas are characterized by a histopathological feature of dermal keratin cyst with cyst wall showing radiating hair follicles. We report this case for the rare presentation of multiple trichofolliculomas on the face which clinically mimicked multiple trichoepitheliomas. PMID:25814743

  1. Multiplication Frenzy!

    NSDL National Science Digital Library

    Ms. Burks

    2010-01-27

    Let's practice multiplication! First, try to win the first place medal in the Fish Race. Then, test your skills by blowing up meteors by getting your multiplication tables right in Meteor Buster. Last, don't let the ants eat your lunch in The Ants Go Marching. ...

  2. Representing Multiplication

    ERIC Educational Resources Information Center

    Harries, Tony; Barmby, Patrick

    2008-01-01

    In this study, the authors wish to explore the use of visual representations in facilitating the understanding of multiplication. In doing so, they examine the different aspects of multiplication that they can access through different representations. In addition, they draw on a study that they have been carrying out looking at pupils' actual use…

  3. Therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress

    NASA Astrophysics Data System (ADS)

    Okereke, Emmanuel O.

    2000-09-01

    This quasi-experiment study examined the therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress. By utilizing drug interventions that reduced cardiovascular distress through changes in the hypertensive indices, previous studies have shown that improvements in life expectancy, lowering of health care costs in later years, and reduction in all-cause mortality were achieved. In fact, individuals without risk factors or with low risk factors for cardiovascular disease in young adulthood or middle age were healthier, had a greater life expectancy, and incurred lower health care costs in later years. The hypertensive indices of interest include elevated heart rate (HR), systolic blood pressure (Ps), diastolic blood pressure (PD), mean arterial blood pressure (MABP), pulse pressure (PP), and mechanical disadvantages of the heart MDH. Mechanical disadvantage of the heart is a term that has been developed for the purposes of this study. The alternative hypotheses for this study proposed to show a significant change in the relevant hypertensive indices of cardiovascular distress in volunteers after a minimum of 45 days treatment with multiple nutritional supplements. The target population was all middle-aged (30 to 65 years) volunteer hypertensives in Nigeria (West Africa), who were randomly assigned to either the experimental group or control group, controlling for individuals who were on any form of medication, smokers, alcoholics, and those who were pregnant or on contraceptives. Treatment involved multiple doses of the various vitamins, minerals, essential amino acids, essential fatty acids, and accessory nutrients in their complementary combinations that influence various levels of cardiovascular function. After 45 days of treatment, the differences between the mean sores of the experimental group and control group on Ps, PD, MABP, and PP were found to be statistically significant, at p ? .05 cut-off level for rejecting the null hypothesis for each dependent variable on a one-tailed student's t test. The same results were not demonstrated for HR and MDH. In summary, the therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress could provide a cost-effective, safe, healthy, and reliable way of preventing cardiovascular disease.

  4. Aggregation across multiple indicators improves the detection of malingering: relationship to likelihood ratios.

    PubMed

    Larrabee, Glenn J

    2008-07-01

    Recent literature shows that aggregating across multiple symptom validity test (SVT) failures increases the probability of malingering over use of one indicator alone, supporting the criteria proposed by Slick, Sherman, and Iverson (1999) that require multiple sources of evidence for diagnosis of malingering. The present study reanalyzes with likelihood ratios data previously published by Larrabee (2003a) on litigants with definite malingering, contrasted with non-malingering patients with moderate and severe traumatic brain injury. Chaining of likelihood ratios demonstrated an increase in probability of malingering when multiple test scores were positive, with values ranging from. 713 to. 837 for one failed SVT,. 936 to. 973 for two failed SVTs, and. 989 to. 995 for three failed SVTs. Posterior probabilities of malingering derived from chaining of likelihood ratios closely approximated those obtained by direct computation of Positive Predictive Power, particularly when three SVTs were failed. Moreover, the five SVTs employed in these analyses did not intercorrelate significantly, satisfying the assumption that the tests be independent for chaining of likelihood ratios. Posterior probabilities derived from chaining of likelihood ratios, holding sensitivity and specificity constant at. 50 and. 90, respectively, and varying the malingering base rate from. 10 to. 90, showed a wide range of values,. 357 to. 978, for failure of one SVT. Failure of two SVTs yielded probabilities ranging from. 735 to. 996. Failure of three SVTs yielded values ranging from. 933 to. 999, demonstrating high probabilities of malingering irrespective of the base rate. These data support the Slick et al. recommendation that multiple positive findings are necessary for diagnosis of malingering. Suggestions are made for modification of the Slick et al. criteria based on the current results. PMID:17886147

  5. Multiplication Matho

    NSDL National Science Digital Library

    A + Math

    2007-12-12

    This site has students practice their multiplication facts. They compete against the clock while picking the correct response from numerous choices. Student have Matho when they get five colored snakes in a row.

  6. Multiple myeloma

    PubMed Central

    2010-01-01

    Abstract Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. This article summarises the current status and highlights how an understanding of both is necessary for optimum management. PMID:20159661

  7. Multiple Pregnancy

    MedlinePLUS Videos and Cool Tools

    ... and fraternal. What is the role of fertility drugs and Assisted Reproductive Technology in causing multiple pregnancy? ... about 1% have triplets or more. Use of drugs to cause superovulation has caused the vast majority ...

  8. Monitoring marine recreational water quality using multiple microbial indicators in an urban tropical environment

    PubMed Central

    Shibata, Tomoyuki; Solo-Gabriele, Helena M.; Fleming, Lora E.; Elmir, Samir

    2008-01-01

    The microbial water quality at two beaches, Hobie Beach and Crandon Beach, in Miami-Dade County, Florida, USA was measured using multiple microbial indicators for the purpose of evaluating correlations between microbes and for identifying possible sources of contamination. The indicator microbes chosen for this study (enterococci, Escherichia coli, fecal coliform, total coliform and C. perfringens) were evaluated through three different sampling efforts. These efforts included daily measurements at four locations during a wet season month and a dry season month, spatially intensive water sampling during low- and high-tide periods, and a sand sampling effort. Results indicated that concentrations did not vary in a consistent fashion between one indicator microbe and another. Daily water quality frequently exceeded guideline levels at Hobie Beach for all indicator microbes except for fecal coliform, which never exceeded the guideline. Except for total coliform, the concentrations of microbes did not change significantly between seasons in spite of the fact that the physical–chemical parameters (rainfall, temperature, pH, and salinity) changed significantly between the two monitoring periods. Spatially intense water sampling showed that the concentrations of microbes were significantly different with distance from the shoreline. The highest concentrations were observed at shoreline points and decreased at offshore points. Furthermore, the highest concentrations of indicator microbe concentrations were observed at high tide, when the wash zone area of the beach was submerged. Beach sands within the wash zone tested positive for all indicator microbes, thereby suggesting that this zone may serve as the source of indicator microbes. Ultimate sources of indicator microbes to this zone may include humans, animals, and possibly the survival and regrowth of indicator microbes due to the unique environmental conditions found within this zone. Overall, the results of this study indicated that the concentrations of indicator microbes do not necessarily correlate with one another. Exceedence of water quality guidelines, and thus the frequency of beach advisories, depends upon which indicator microbe is chosen. PMID:15261551

  9. Multiple primaries in pancreatic cancer patients: indicator of a genetic predisposition?

    Microsoft Academic Search

    Berthold Gerdes; Andreas Ziegler; Annette Ramaswamy; Peter Langera; Detlef K Bartscha

    2000-01-01

    Background The genetic basis of several familial cancers including breast and colon cancers has been identified recently. The occurrence of multiple cancers in one individual is also suggestive of a genetic predisposition. To evaluate inherited predisposition in pancreatic cancer we compared the clinical data of pancreatic cancer patients with and without multiple primaries as well as the frequency of malignancies

  10. An earthquake detection algorithm with pseudo-probabilities of multiple indicators

    NASA Astrophysics Data System (ADS)

    Ross, Z. E.; Ben-Zion, Y.

    2014-04-01

    We develop an automatic earthquake detection algorithm combining information from numerous indicator variables in a non-parametric framework. The method is shown to perform well with multiple ratios of moving short- and long-time averages having ranges of time intervals and frequency bands. The results from each indicator are transformed to a pseudo-probability time-series (PPTS) in the range [0, 1]. The various PPTS of the different indicators are multiplied to form a single joint PPTS that is used for detections. Since all information is combined, redundancy among the different indicators produces robust peaks in the output. This allows the trigger threshold applied to the joint PPTS to be significantly lower than for any one detector, leading to substantially more detected earthquakes. Application of the algorithm to a small data set recorded during a 7-d window by 13 stations near the San Jacinto fault zone detects 3.13 times as many earthquakes as listed in the Southern California Seismic Network catalogue. The method provides a convenient statistical platform for including other indicators, and may utilize different sets of indicators to detect other information such as specific seismic phases or tremor.

  11. An array sensor consisting of a single indicator with multiple concentrations and its application in ion discrimination.

    PubMed

    Li, Hui; Jia, Mingyan; Askim, Jon R; Zhang, Yu; Duan, Chunfeng; Guan, Yafeng; Feng, Liang

    2014-12-18

    Optical sensor arrays typically require a large set of chemically responsive colorants to enhance discrimination capability. Conversely, we have proven that by using multiple concentrations of one indicator, the discrimination of various analytes could be realized. PMID:25350153

  12. STABILITY OF MULTIPLICATION OPERATORS AND MULTIPLICATION

    E-print Network

    STABILITY OF MULTIPLICATION OPERATORS AND MULTIPLICATION SEMIGROUPS FATIH BAYAZIT, RETHA HEYMANN Abstract. We investigate uniform, strong, weak and almost weak stability of multiplication semigroups transform is that it converts a differential operator into a multiplication operator induced by some scalar

  13. Multiplication Mania

    NSDL National Science Digital Library

    Ms. Macumber

    2008-10-01

    Multiplication Mania is alive & well in 4A! With this online project, you can click on the links below & turn into a multiplication maniac no matter where you are.... Who Wants to Be a Mathionaire? See if you can earn enough money to call yourself a Mathionaire Millionaire! What facts do you need to practice? Choose here & improve your Superstars status! Do you want to practice x5? x2? x4? Choose your number & then Race Against Red to see how well you ...

  14. Lattice Multiplication

    NSDL National Science Digital Library

    Interactive Math Miscellany and Puzzles, Alexander Bogomolny

    2011-01-01

    Leonardo Fibonacci's multiplication algorithm arrays the digits of multiplicands along a rectangular lattice. Read an explanation of the technique, see a few worked examples, and watch the method in action with a Java applet. Clicking a little off-center of any digit of a multiplicand (left to increase, right to decrease) instantly changes resulting products and sums throughout the lattice.

  15. Multiplication Madness!

    NSDL National Science Digital Library

    Miss Schieffer

    2009-04-21

    Practice multiplying with these fun math games! Warm up your multiplication skills with Jungle Jim as you help him multiply with the monkeys! Begin with multiplying by 2 and move up. Next, quench your thirst with the Lemonade Game as you help calculate how much money you should get for each cup of lemonade you sell. Use the number keys ...

  16. Multiple sclerosis

    Microsoft Academic Search

    John W. Rose

    1996-01-01

    Multiple sclerosis is a chronic disease that begins in late adolescence or adulthood. It is highly variable in its expression and severity. It is believed to be autoimmune in nature. The cause is unknown; both genetic and environmental factors have been implicated in the pathogenesis. MS generally presents with the acute or subacute onset of neurologic abnormalities that may wax

  17. Multiplication Game

    NSDL National Science Digital Library

    Hooda Math

    2013-03-13

    This iOS app helps develop strategic thinking and fluency with multiplication facts. Two players take turns selecting one of two factors, 1 - 9, in order to capture products on a grid. The winner is the first player to capture four in a row. This game can be played by two players or one player against the computer.

  18. Finger Multiplication

    ERIC Educational Resources Information Center

    Holmes, Bill

    2010-01-01

    The author has been prompted to write this article about finger multiplication for a number of reasons. Firstly there are a number of related articles in past issues of "Mathematics Teaching" ("MT") which have connections to this algorithm. Secondly, very few of his primary teaching students and professional colleagues appear to be aware of the…

  19. Multiple Intelligences.

    ERIC Educational Resources Information Center

    Laughlin, Janet

    1999-01-01

    Details the characteristics of Howard Gardner's seven multiple intelligences (MI): linguistic, logical-mathematical, bodily-kinesthetic, spatial, musical, interpersonal, and intrapersonal. Discusses the implications of MI for instruction. Explores how students can study using their preferred learning style - visual, auditory, and physical study…

  20. Multiple Sclerosis.

    ERIC Educational Resources Information Center

    Plummer, Nancy; Michael, Nancy, Ed.

    This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

  1. Multiple sclerosis

    PubMed Central

    Boster, Aaron L.; Racke, Michael K.

    2013-01-01

    Summary Preliminary studies have suggested that a high salt diet may play a role in the development of autoimmune disease and possibly multiple sclerosis (MS). Promising clinical trial results for 2 new therapies for MS have been reported. Dimethyl fumarate, also known by its investigational name BG-12, became the third oral disease-modifying therapy for MS to be Food and Drug Administration (FDA)–approved in March 2013. Interestingly, dimethyl fumarate served as the active compound used for the treatment of psoriasis for decades. Alemtuzumab remains under investigation and is not currently FDA-approved for treatment of MS. Other drugs currently approved for alternative indications are being investigated for use in MS. Additionally, an investigation of alternative dosing strategies for glatiramer acetate suggests that patients may benefit from a higher dose formulation and less frequent medication administration. Advances in basic science research have identified another potential autoantigenic target in MS, KIR4.1, which may provide further insight into MS pathophysiology. PMID:24175156

  2. Large-Scale Diversity of Slope Fishes: Pattern Inconsistency between Multiple Diversity Indices

    PubMed Central

    Gaertner, Jean-Claude; Colloca, Francesco; Politou, Chrissi-Yianna; Gil De Sola, Luis; Bertrand, Jacques A.; Murenu, Matteo; Durbec, Jean-Pierre; Kallianiotis, Argyris; Mannini, Alessandro

    2013-01-01

    Large-scale studies focused on the diversity of continental slope ecosystems are still rare, usually restricted to a limited number of diversity indices and mainly based on the empirical comparison of heterogeneous local data sets. In contrast, we investigate large-scale fish diversity on the basis of multiple diversity indices and using 1454 standardized trawl hauls collected throughout the upper and middle slope of the whole northern Mediterranean Sea (36°3?- 45°7? N; 5°3?W - 28°E). We have analyzed (1) the empirical relationships between a set of 11 diversity indices in order to assess their degree of complementarity/redundancy and (2) the consistency of spatial patterns exhibited by each of the complementary groups of indices. Regarding species richness, our results contrasted both the traditional view based on the hump-shaped theory for bathymetric pattern and the commonly-admitted hypothesis of a large-scale decreasing trend correlated with a similar gradient of primary production in the Mediterranean Sea. More generally, we found that the components of slope fish diversity we analyzed did not always show a consistent pattern of distribution according either to depth or to spatial areas, suggesting that they are not driven by the same factors. These results, which stress the need to extend the number of indices traditionally considered in diversity monitoring networks, could provide a basis for rethinking not only the methodological approach used in monitoring systems, but also the definition of priority zones for protection. Finally, our results call into question the feasibility of properly investigating large-scale diversity patterns using a widespread approach in ecology, which is based on the compilation of pre-existing heterogeneous and disparate data sets, in particular when focusing on indices that are very sensitive to sampling design standardization, such as species richness. PMID:23843962

  3. Multiple indications for everolimus after liver transplantation in current clinical practice

    PubMed Central

    Bilbao, Itxarone; Dopazo, Cristina; Lazaro, Jose; Castells, Lluis; Caralt, Mireia; Sapisochin, Gonzalo; Charco, Ramon

    2014-01-01

    AIM: To assess our experience with the use and management of everolimus-based regimens post-liver transplantation and to redefine the potential role of this drug in current clinical practice. METHODS: From October 1988 to December 2012, 1023 liver transplantations were performed in 955 patients in our Unit. Seventy-four patients (7.74%) received immunosuppression with everolimus at some time post-transplantation. Demographic characteristics, everolimus indication, time elapsed from transplantation to the introduction of everolimus, doses and levels administered, efficacy, side effects, discontinuation and post-conversion survival were analyzed. RESULTS: Mean age at the time of conversion to everolimus was 57.7 ± 10 years. Indications for conversion were: refractory rejection 31.1%, extended hepatocellular carcinoma in explanted liver 19%, post-transplant hepatocellular carcinoma recurrence 8.1%, de novo tumour 17.6%, renal insufficiency 8.1%, severe neurotoxicity 10.8%, and others 5.4%. Median time from transplantation to introduction of everolimus was 6 mo (range: 0.10-192). Mean follow-up post-conversion was 22 ± 19 mo (range: 0.50-74). The event for which the drug was indicated was resolved in 60.8% of patients, with the best results in cases of refractory rejection, renal insufficiency and neurotoxicity. Results in patients with cancer were similar to those of a historical cohort treated with other immunosuppressants. The main side effects were dyslipidemia and infections. Post-conversion acute rejection occurred in 14.9% of cases. The drug was discontinued in 28.4% of patients. CONCLUSION: Everolimus at low doses in combination with tacrolimus is a safe immunosuppressant with multiple early and late indications post-liver transplantation. PMID:25032101

  4. Multiple Sclerosis

    Microsoft Academic Search

    Alex C. Tselis; Omar A. Khan

    Multiple sclerosis (MS) has emerged as a treatable disorder with several disease-modifying therapies (DMTs) now licensed in\\u000a the United States for MS treatment. These are interferon (IFN)-?-1a (two formulations, Avonex and Rebif), IFN-?-1b (Betaseron),\\u000a glatiramer acetate (GA) (Copaxone), and mitoxantrone (Novantrone). Although all five DMTs were tested in phase III randomized\\u000a controlled trials (RCTs) and shown to be superior to

  5. Multiple Sclerosis

    Microsoft Academic Search

    William A. Sheremata

    Multiple sclerosis (MS) was first described by Charcot in mid-19th century Paris. Charcot, however, attributed the original\\u000a recognition of this disorder to Cruveillier, the famed professor of anatomy. Although others also described the pathological\\u000a anatomy of the disease in remarkable detail, it was Charcot who characterized the clinical illness and correlated the illness\\u000a with its unique neuropathology (1). From the

  6. Multiplication Mania!

    NSDL National Science Digital Library

    Mrs. Reeves

    2006-11-06

    You\\'ve been practicing your multiplication facts, these games will help you develop your skills! First, you will read some stories that may help you remember your 9 X Tables better. Read through these stories and pick your favorite to share with a partner sitting close to you. Click here 9 X Tables Stories With this game, you need to save the mokeys apples so the crocodile wont eat ...

  7. MULTIPLE TIDAL DISRUPTIONS AS AN INDICATOR OF BINARY SUPERMASSIVE BLACK HOLE SYSTEMS

    SciTech Connect

    Wegg, Christopher; Nate Bode, J., E-mail: wegg@tapir.caltech.edu [Theoretical Astrophysics, California Institute of Technology, MC 350-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States)

    2011-09-01

    We find that the majority of systems hosting multiple tidal disruptions (TDs) are likely to contain hard binary supermassive black hole (SMBH) systems, and also show that the rates of these repeated events are high enough to be detected by the Large Synoptic Survey Telescope (LSST) over its lifetime. Therefore, these multiple TD events provide a novel method for identifying SMBH binary systems with parsec to subparsec separations. The rates of TDs are investigated using simulations of non-interacting stars initially orbiting a primary SMBH and the potential of the model stellar cusp. The stars are then evolved forward in time and perturbed by a secondary SMBH inspiraling from the edge of the cusp to its stalling radius. We find with conservative magnitude estimates that the next-generation transient survey LSST should detect multiple TDs in approximately three galaxies over five years of observation, though less conservative estimates could increase this rate by an order of magnitude.

  8. Effect of Partial Parenteral Versus Enteral Nutritional Therapy on Serum Indices in Multiple Trauma Patients

    Microsoft Academic Search

    Noor Mohammad Arefian; Hooman Teymourian; Badiolzaman Radpay

    Background : Malnutrition is a common complication in multiple trauma patients because of the metabolic and catabolic increase and negative nitrogen balance. It may deteriorate patients' outcome. Some clinical and paraclinical parameters are used for nutritional assessment. In this study our goal was evaluation of nutritional parameters in enteral and partial parenteral methods for detecting the better method of nutritional

  9. Adolescent Non-Involvement in Multiple Risk Behaviors: An Indicator of Successful Development?

    ERIC Educational Resources Information Center

    Willoughby, Teena; Chalmers, Heather; Busseri, Michael A.; Bosacki, Sandra; Dupont, Diane; Marini, Zopito; Rose-Krasnor, Linda; Sadava, Stan; Ward, Anthony; Woloshyn, Vera

    2007-01-01

    Based on the conceptualization of successful development as the joint maximization of desirable outcomes and minimization of undesirable outcomes (Baltes, 1997), the present study examined connections between adolescent non-involvement in multiple risk behaviors and positive developmental status. Results from a survey of 7290 high school students…

  10. The Effects of Nonverbal and Verbal Immediacy on Recall and Multiple Student Learning Indicators

    ERIC Educational Resources Information Center

    Goodboy, Alan K.; Weber, Keith; Bolkan, San

    2009-01-01

    A 2 x 2 experiment was conducted in which instructor nonverbal immediacy and verbal immediacy were manipulated in a college classroom to examine causal links with cognitive and affective learning outcomes. Previous criticisms concerning immediacy and learning research were considered and multiple operationalizations of cognitive learning (i.e.,…

  11. A Multiple Indicators Multiple Cause (MIMIC) model of respiratory health and household factors in Chinese children: the seven Northeastern cities (SNEC) study.

    PubMed

    Dong, Guang-Hui; Qian, Zhengmin; Fu, Qiang; Wang, Jing; Trevathan, Edwin; Ma, Wenjun; Liu, Miao-Miao; Wang, Da; Ren, Wan-Hui; Ong, Kee-Hean; Ferguson, Tekeda Freeman; Riley, Erin; Simckes, Maayan

    2014-01-01

    In China, with the rapid economic development and improvement of living standards over the past few decades, the household living environment has shifted dramatically. The aim of the present study is to assess the impact of home environment factors on respiratory symptoms and asthma in Chinese children. Investigators analyzed data collected in the 25 districts from the seven Northeastern cities to examine health effects on respiratory symptoms and asthma in 31,049 children aged 2-14 years. Factor analysis was used to reduce 33 children's lifestyle and household variables to six new 'factor' variables. The multiple indicators multiple causes approach was used to examine the relationship between indoor air pollution and respiratory health status, controlling for covariates. Factor analyses generated six factor variables of potential household risk factors from an original list of 33 variables. The respiratory symptoms and asthma were significantly associated with the recent home renovation factor (estimate = 0.076, p < 0.001), pet ownership factor (estimate = 0.095, p < 0.001), environmental tobacco smoke (ETS) exposure factor (estimate = 0.181, p < 0.001) and PVC-flooring factor (estimate = 0.031, p = 0.007). Home ventilation factor was not related to any respiratory condition (estimate = 0.028, p = 0.074). Independent respiratory health effects existed for multiple household environmental factors recent home renovation, pet ownership, ETS, and PVC-flooring. PMID:23440490

  12. Assessment of lung injury in the adult respiratory distress syndrome using multiple indicator dilution curves

    SciTech Connect

    Rinaldo, J.E.; Borovetz, H.S.; Mancini, M.C.; Hardesty, R.L.; Griffith, B.P.

    1986-06-01

    To assess its usefulness as an index of lung injury in critically ill patients with respiratory failure, the lung microvascular permeability surface area product for urea (/sup 14/C-PSu) was measured using a multiple radioisotopic indicator dilution technique in 10 patients with the adult respiratory distress syndrome (ARDS) and in a control population of 5 patients without ARDS. The mean values for /sup 14/C-PSu and for extravascular lung water (EVLW) were both significantly elevated in patients with ARDS compared with those in control patients (/sup 14/C-PSu: 18.7 +/- 4.4 versus 7.6 +/- 0.7, p less than 0.05; EVLW: 676 +/- 55 versus 269 +/- 53, p less than 0.001); /sup 14/C-PSu and EVLW were significantly correlated (R = 0.52, p less than 0.001). In the patients with ARDS, /sup 14/C-PSu and oxygenation, assessed as the alveolar-arterial oxygen difference, did not appear to be correlated. Repeated measurements of /sup 14/C-PSu were variable in the 3 control patients in whom 4 or more measurements were obtained (SD = 50, 57, and 54% of the mean values, respectively); /sup 14/C-PSu did not predict clinical outcome assessed by survival of individual patients with ARDS. These data suggest that measurement of /sup 14/C-PSu in critically ill patients is a clinically applicable parameter that reflects the degree of microvascular injury in groups of patients. However, our study did not indicate a clear advantage of /sup 14/C-PSu over EVLW in assessing lung injury in this patient population. The variability in /sup 14/C-PSu control patients also suggests that directional changes in /sup 14/C-PSu, as a measure of changes in the degree of lung microvascular dysfunction, should be interpreted with caution.

  13. Multiple Sclerosis

    PubMed Central

    2013-01-01

    Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system. Common manifestations include paresthesias, diplopia, loss of vision, numbness or weakness of the limbs, bowel or bladder dysfunction, spasticity, ataxia, fatigue, and mental changes. Four main patterns of MS are recognized: relapsing remitting, primary progressive, secondary progressive, and progressive relapsing. The cause of MS is unknown, although it appears to be an autoimmune disease. Much of what is known about MS has been learned from an animal model of the disease, experimental allergic encephalomyelitis. PMID:24381825

  14. Multiple sclerosis.

    PubMed

    Files, Daniel Kane; Jausurawong, Tani; Katrajian, Ruba; Danoff, Robert

    2015-06-01

    Multiple sclerosis (MS) is a chronic, debilitating disease that can have devastating effects. Presentation varies widely in symptoms, pace, and progression. In addition to a thorough history and physical examination, diagnostic tools required to diagnose MS and exclude other diagnoses include MRI, evoked potential testing, and cerebrospinal fluid analysis. Although the disease is not curable presently, quality of life can be improved by minimizing the frequency and severity of disease burden. Disease modification, symptom management, preservation of function, and treatment of psychosocial issues are paramount to enhance the quality of life for the patient affected with MS. PMID:25979578

  15. Modeling Multiplication with Fractions

    NSDL National Science Digital Library

    Joseph Ratasky

    2012-08-18

    Students will relate multiplication strategies with fractions through problem solving situations. This lesson connects prior understanding of multiplication and equal groups to multiplication of fractions.

  16. Evaluation of prognostic indicators in dogs with multiple, simultaneously occurring cutaneous mast cell tumours: 63 cases.

    PubMed

    O'Connell, K; Thomson, M

    2013-03-01

    Sixty-three dogs with multiple contemporaneous cutaneous mast cell tumours (MCTs) were identified. The aim of this study was to determine the significance of breed, concurrent dermatological condition; number of cutaneous MCTs, size, location, histological grade and mitotic index; completeness of excision (complete, close or incomplete); local recurrence, metastasis and adjuvant therapy for the prognostic evaluation of dogs with a unique disease presentation of multiple, simultaneously occurring cutaneous MCTs. On the basis of multivariable survival analysis, dogs with one recorded grade 3 MCT had shorter progression-free survival (PFS) times (18.7 versus 2.2 months) and median survival times (MSTs) (24 versus 3 months). Dogs treated with adjuvant vinblastine/lomustine had a 16 times increased risk of dying. MSTs were found to be significantly longer in dogs with one recorded MCT on an extremity. For all dogs, the PFS (range 14-1835 days) and MSTs (range 28-1835 days) were not reached. PMID:22235766

  17. Human health risk implications of multiple sources of faecal indicator bacteria in a recreational waterbody.

    PubMed

    Soller, Jeffrey A; Schoen, Mary E; Varghese, Arun; Ichida, Audrey M; Boehm, Alexandria B; Eftim, Sorina; Ashbolt, Nicholas J; Ravenscroft, John E

    2014-12-01

    We simulate the influence of multiple sources of enterococci (ENT) as faecal indicator bacteria (FIB) in recreational water bodies on potential human health risk by considering waters impacted by human and animal sources, human and non-pathogenic sources, and animal and non-pathogenic sources. We illustrate that risks vary with the proportion of culturable ENT in water bodies derived from these sources and estimate corresponding ENT densities that yield the same level of health protection that the recreational water quality criteria in the United States seeks (benchmark risk). The benchmark risk is based on epidemiological studies conducted in water bodies predominantly impacted by human faecal sources. The key result is that the risks from mixed sources are driven predominantly by the proportion of the contamination source with the greatest ability to cause human infection (potency), not necessarily the greatest source(s) of FIB. Predicted risks from exposures to mixtures comprised of approximately 30% ENT from human sources were up to 50% lower than the risks expected from purely human sources when contamination is recent and ENT levels are at the current water quality criteria levels (35 CFU 100 mL(-1)). For human/non-pathogenic, human/gull, human/pig, and human/chicken faecal mixtures with relatively low human contribution, the predicted culturable enterococci densities that correspond to the benchmark risk are substantially greater than the current water quality criteria values. These findings are important because they highlight the potential applicability of site specific water quality criteria for waters that are predominantly un-impacted by human sources. PMID:25222329

  18. Application of multiple ecological risk indices for the evaluation of heavy metal contamination in a coastal dredging area

    Microsoft Academic Search

    Y.-T. Kwon; C.-W. Lee

    1998-01-01

    Toxic compounds such as heavy metals exert chronic and lethal effects in animals and plants. There is a need to analyze the contamination level and the biological effect rather than to simply compare the heavy metal contents. Heavy metal contamination in sediments from Masan Bay were evaluated by multiple ecological risk indices before and after a sediment dredging process. The

  19. Using Multiple Calibration Indices in Order to Capture the Complex Picture of What Affects Students' Accuracy of Feeling of Confidence

    ERIC Educational Resources Information Center

    Boekaerts, Monique; Rozendaal, Jeroen S.

    2010-01-01

    The present study used multiple calibration indices to capture the complex picture of fifth graders' calibration of feeling of confidence in mathematics. Specifically, the effects of gender, type of mathematical problem, instruction method, and time of measurement (before and after problem solving) on calibration skills were investigated. Fourteen…

  20. Multiple myeloma.

    PubMed Central

    MacLennan, I. C.; Drayson, M.; Dunn, J.

    1994-01-01

    Multiple myeloma occurs in over 2000 new patients in England and Wales each year. It presents most frequently as bone pain and patients tend to become dehydrated and may develop renal failure. No available treatment is curative, but about two thirds of patients achieve a stable response with low dose combination chemotherapy. Combination chemotherapy including doxorubicin and carmustine with the alkylating agents cyclophosphamide and melphalan achieve a higher stable response rate than conventional treatment with melphalan and prednisone without additional haematological toxicity. These responses are associated with loss of bone pain and patients remain symptom free for months without further treatment. Relapse occurs on average in a little under two years and, though second responses are frequently obtained, the disease eventually becomes refractory. This paper looks at who should be treated and the benefits that may be expected from the treatments available. PMID:8068084

  1. Asset life prediction using multiple degradation indicators and lifetime data: A gamma-based state space model approach

    Microsoft Academic Search

    Yifan Zhou; Lin Ma; Joseph Mathew; Hack-Eun Kim; Rodney Wolff

    2009-01-01

    This paper proposes a Gamma-based state space model to predict engineering asset life when multiple degradation indicators are involved and the failure threshold on these indicators are uncertain. Monte Carlo-based parameter estimation and model inference algorithms are developed to deal with the proposed Gamma-based state space model. A case study using real data from industry is conducted to compare the

  2. Introduction Multiple Mules

    E-print Network

    Karp, Brad

    Introduction Multiple Mules Results / Conclusion Appraisal 4C38 Presentation: "Multiple Data MulesEE, UCLA 4C38 Presentation: "Multiple Data Mules" 1/36 #12;Introduction Multiple Mules Results / Conclusion by long ears and a short mane. 4C38 Presentation: "Multiple Data Mules" 2/36 #12;Introduction Multiple

  3. Complex multiplication Real multiplication On CM and RM constructions

    E-print Network

    Kohel, David R.

    Complex multiplication Real multiplication On CM and RM constructions of abelian surfaces David R 2009 #12;Complex multiplication Real multiplication On CM and RM constructions of abelian surfaces multiplication Real multiplication Contents 1 Complex multiplication CM overview Motivation: Number theory

  4. Multiple Episodes of Recent Gully Activity Indicated by Gully Fan Stratigraphy in Eastern Promethei Terra, Mars.

    NASA Astrophysics Data System (ADS)

    Schon, S.; Head, J.; Fassett, C.

    2008-09-01

    Introduction Gullies are considered among the youngest geomorphic features on Mars based upon their stratigraphic relationships, superposition on steep slopes and distinctive morphology in unconsolidated sediment. Multiple formation hypotheses have been proposed, which can be divided into three broad classes: entirely dry mechanisms (e.g., [1,2]), wet mechanisms invoking groundwater or ground ice (e.g., [3,4]) and wet mechanisms invoking surficial meltwater (e.g., [5,6,7,8]). It has been difficult to differentiate between these hypotheses based upon past observations and it remains possible that gullies are polygenetic landforms. This study presents stratigraphic relationships in the depositional fan of a crater wall gully system that suggest: (1) multiple episodes of alluvial fan-style deposition, (2) very recent depositional activity that is younger than a newly recognized rayed crater, and (3) surficial snowmelt as the most likely source of these multiple episodes of recent gully activity. Gully-Fan Stratigraphy In Eastern Promethei Terra an ~5 km-diameter crater is observed with a well-developed gully system (Fig. 1) and several smaller gullies in its northnortheast wall. The large gully system (composed of a small western gully and larger eastern gully) shows evidence for incision into the crater wall country rock and has multiple contributory sub-alcoves and channels. The depositional fan associated with this gully system is bounded on its western side by a small arcuate ridge swell that is not observed on the eastern side of the fan. This ridge is interpreted as a moraine-like structure that may have bounded a glacially-formed depression into which the fan is deposited [8]. Similar depressions with bounding ridges are commonly observed in this latitude band (~30-50°S) in association with deeply incised gully alcoves [9,10,11]. This gully fan is composed of multiple lobes with distinct lobe contacts, incised channels, and cut-andfill deposits - all features similar to those seen in terrestrial alluvial fans [12,13]. The western portion of the fan is contained within the depression, while the younger eastern portion overlies and obscures any potential evidence of the ridge structure. A very striking and unusual feature of this gully fan is the large number of superposed impact craters; due to their density and similar diameter, we interpret these to be secondary craters from a large nearby primary impact crater. The depositional lobes of the fan can be divided into two groups: 1) those that predate the secondary crater population and 2) younger lobes that are superposed on the secondary craters. Numerous secondary craters (~1-25 m-diameter) superpose the lowermost stratigraphic lobe (Fig. 1, A), while at least three younger lobes (Fig. 1, C1, D1, and D2) directly superpose the cratered lobe. The emplacement date of these secondaries provides a robust maximum age for the youngest lobes of this fan, and therefore the most recent fluvial activity of the gully. Most gullies either have no superposed impact craters [3,7] or are too small to date with any certainty using crater counts [14]. Therefore, locating and dating the parent impact crater of these secondaries is critical to constrain the chronology and origin of gully systems. Rayed-Crater Source of the Secondary Craters Regional reconnaissance for the origin of the secondary craters led to the discovery of a previously unidentified rayed crater complex (consisting of an ~18 km-diameter outer crater and an ~7 km-diameter inner crater) approximately 175 km southwest of the gully system. Distinctive rays are observed in THEMIS nighttime thermal inertia data, but are not observable as albedo contrasts in THEMIS visible data, consistent with other identifications of young rayed craters on Mars [15,16]. The rims of both craters are distinct and consistent with the morphology of very young impact craters on Mars. The inner crater has a greater depth to diameter ratio than the outer crater (0.121 compared to 0.073), consistent with young Martian craters [17]. Both the ou

  5. Evaluating multiple indices of agricultural water use efficiency and productivity to improve comparisons between sites and trends

    NASA Astrophysics Data System (ADS)

    Levy, M. C.

    2012-12-01

    Approximately 70% of global available freshwater supplies are used in the agricultural sector. Increased demands for water to meet growing population food requirements, and expected changes in the reliability of freshwater supplies due to climate change, threaten the sustainability of water supplies worldwide - not only on farms, but in connected cities and industries. Researchers concerned with agricultural water use sustainability use a variety of theoretical and empirical measures of efficiency and productivity to gain insight into the sustainability of agricultural water use. However, definitions of measures, or indices, vary between different natural and political boundaries, across regions, states and nations and between their respective research, industry, and environmental groups. Index development responds to local data availability and local agendas, and there is debate about the validity of various indices. However, real differences in empirical index measures are not well-understood across the multiple disciplines that study agricultural water use, including engineering and hydrology, agronomy, climate and soil sciences, and economics. Nevertheless reliable, accessible, and generalizable indices are required for planners and policymakers to promote sustainable water use systems. This study synthesizes a set of water use efficiency and productivity indices based on academic, industry and government literature in California and Australia, two locations with similarly water-stressed and valuable agricultural industries under pressure to achieve optimal water use efficiency and productivity. Empirical data at the irrigation district level from the California San Joaquin Valley and Murray Darling Basin states of Victoria and New South Wales in Australia are used to compute indices that estimate efficiency, yield productivity, and economic productivity of agricultural water use. Multiple index estimates of same time-series data demonstrate historical spread in efficiency and productivity measures in different agricultural regions. Individual indices consistently over- or under- estimate trends in efficiency and productivity by their construction, and may provide inaccurate results in years with extreme climatic events, such as droughts. By treating multiple indices as an "ensemble" of measures, analogous to the treatment of multiple climate model predictions, this study quantifies likely "true" states of efficiency and productivity in the selected agricultural regions, and error in individual indices. While different individual indices are preferable at different scales, and relative to the quality of available input data, ensemble indices can be more reliably used in comparative study across different agricultural regions, and for prediction.

  6. Factorial Invariance in Multiple Populations: A Multiple Testing Procedure

    ERIC Educational Resources Information Center

    Raykov, Tenko; Marcoulides, George A.; Millsap, Roger E.

    2013-01-01

    A multiple testing method for examining factorial invariance for latent constructs evaluated by multiple indicators in distinct populations is outlined. The procedure is based on the false discovery rate concept and multiple individual restriction tests and resolves general limitations of a popular factorial invariance testing approach. The…

  7. Multiple hypothesis tracking for multiple target tracking

    Microsoft Academic Search

    SAMUEL S. BLACKMAN

    2004-01-01

    Multiple hypothesis tracking (MHT) is generally accepted as the preferred method for solving the data association problem in modern multiple target tracking (MTT) systems. This paper summarizes the motivations for MHT, the basic principles behind MHT and the alternative implementations in common use. It discusses the manner in which the multiple data association hypotheses formed by MHT can be combined

  8. Validated, stability-indicated quantitative purity test for triethylenetetramine tetrachlorhydrate by automated multiple development.

    PubMed

    Dauphin, C; Poirier, D; Pradeau, D

    2007-07-01

    There is a monography of Triethylenetetramine dichlorhydrate (Trientine) in the United States Pharmacopeia. But neither the base nor the salts di- or tetra-chlorhydrate are in the European Pharmacopeia. Triethylène tetramine tetrachlorhydrate, used by AGEPS now as matural, is more soluble then triethylene tetramine dichlorhydrate. It is administred to patients with Wilson's disease, which results from a congenital lack of the copper metabolism. A quantitative purity test of this drug by automated multiple development high-performance thin-layer chromatography is developed and validated. The validation parameters tested are specifically characterized by retention factor, linearity, limits of detection and quantitation of several nanograms, reliability, and accuracy. To determine impurities, the monography of triethylenetetramine dichlorhydrate in the American Pharmacopeia is tested. This method in classic developing tank requires two mobile phases and is not quantitative. Assays in high-performance liquid chromatography with a different column and mobile phase did not give good results for the separation of impurities. Thus, it is not possible to perform comparative validation of the separation of the impurities. Only the assay of triethylenetetramine with potentiometer detection has been validated. PMID:17626718

  9. Gender as a differential indicator of the employment discrimination experiences of Americans with multiple sclerosis.

    PubMed

    Rumrill, Phillip D; Roessler, Richard T; McMahon, Brian T; Hennessey, Mary L; Neath, Jeanne

    2007-01-01

    Information from the Integrated Mission System of the United States Equal Employment Opportunity Commission (EEOC) was used to investigate the employment discrimination experiences of women and men with multiple sclerosis (MS). Spanning the years 1992 to 2003, the EEOC database included 3,663 allegations of discrimination filed by 2,167 adults with MS. With respect to women and men with MS, the researchers examined the comparability of a) demographic characteristics; b) industry designations, locations, and size of employers; c) the nature of discrimination alleged; and d) the legal outcome or resolution of those allegations. On average, women and men with MS were in their early forties, with the majority of both groups being Caucasian. Both women and men were most likely to allege discrimination related to discharge and reasonable accommodations, although women were more likely to file harassment charges than men. Men with MS were more likely to allege discrimination regarding hiring and reinstatement. Women with MS were more likely to file allegations against employers in the service industries, and men were more likely to file allegations against employers in the construction, manufacturing, and wholesale industries. No gender differences were found in the geographic distribution of allegations. Both groups had comparable rates of merit closures (23% vs. 27%) as a result of the EEOC's investigatory process. Implications for rehabilitation counseling and employer-oriented interventions are discussed. PMID:18057570

  10. Indication of transverse radial flow in high-multiplicity proton-proton collisions at the Large Hadron Collider

    NASA Astrophysics Data System (ADS)

    Ghosh, Premomoy; Muhuri, Sanjib; Nayak, Jajati K.; Varma, Raghava

    2014-03-01

    We analyze the measured spectra of ?±, K±, p(\\bar{p}) in proton-proton (pp) collisions at \\sqrt{s} = 0.9, 2.76 and 7 TeV in the light of blast-wave model to extract the transverse radial flow velocity and kinetic temperature at freeze-out for the system formed in pp collisions. The dependence of the blast-wave parameters on average charged particle multiplicity of event sample or the ‘centrality’ of collisions has been studied and compared with results of similar analysis in nucleus-nucleus (AA) and proton-nucleus (pA) collisions. We analyze the spectra of K_{s}^0, ?(\\bar{\\Lambda }) and ?- also to see the dependence of blast-wave description on the species of produced particles. Within the framework of the blast-wave model, the study reveals indication of collective behavior for high-multiplicity events in pp collisions at LHC. Strong transverse radial flow in high-multiplicity pp collisions and its comparison with that in pA and AA collisions match with predictions from a very recent theoretical work (Shuryak and Zahed 2013 arXiv:hep-ph/1301.4470) that addresses the conditions for applicability of hydrodynamics in pp and pA collisions.

  11. Health-Related Quality of Life and Functional Status Quality Indicators for Older Persons with Multiple Chronic Conditions

    PubMed Central

    Dy, Sydney M.; Pfoh, Elizabeth R.; Salive, Marcel E.; Boyd, Cynthia M.

    2015-01-01

    OBJECTIVES To explore central challenges with translating self-reported measurement tools for functional status and health-related quality of life (HRQOL) into ambulatory quality indicators for older people with multiple chronic conditions (MCCs). DESIGN Review. SETTING Sources including the National Quality Measures Clearinghouse and National Quality Forum were reviewed for existing ambulatory quality indicators relevant to functional status, HRQOL, and people with MCCs. PARTICIPANTS Seven informants with expertise in indicators using functional status and HRQOL. MEASUREMENTS Informant interviews were conducted to explore knowledge about these types of indicators, particularly usability and feasibility. RESULTS Nine important existing indicators were identified in the review. For process, identified indicators addressed whether providers assessed functional status; outcome indicators addressed quality of life. In interviews, informants agreed that indicators using self-reported data were important in this population. Challenges identified included concerns about usability due to inability to discriminate quality of care adequately between organizations and feasibility concerns regarding high data collection burden, with a correspondingly low response rate. Validity was also a concern because evidence is mixed that healthcare interventions can improve HRQOL or functional status for this population. As a possible first step, a structural standard could be systematic collection of these measures in a specific setting. CONCLUSION Although functional status and HRQOL are important outcomes for older people with MCCs, few relevant ambulatory quality indicators exist, and there are concerns with usability, feasibility, and validity. Further research is needed on how best to incorporate these outcomes into quality indicators for people with MCCs. PMID:24320819

  12. Background Ideas for Faster Multiplication Chunky Multiplication Conclusions Adaptive Polynomial Multiplication

    E-print Network

    Roche, Daniel S.

    Background Ideas for Faster Multiplication Chunky Multiplication Conclusions Adaptive Polynomial Multiplication Daniel S. Roche Symbolic Computation Group School of Computer Science University of Waterloo ORCCA Multiplication Chunky Multiplication Conclusions Outline 1 Background Polynomial Multiplication Adaptive Analysis

  13. Become a Multiplication Wizard!

    NSDL National Science Digital Library

    Ms. Robinson

    2010-01-27

    Practice all levels of basic multiplication facts. Are you a math magician? Practice how speedy you can be in Be A Math Magician!. Dress up and race granny in Granny Multiplication Race to make her go faster, answer the problems correctly. Multiplication that makes your mouth water. Multiplication Ice Cream Cones ...

  14. Multiple personality disorder.

    PubMed

    Salama, A A

    1995-02-01

    This paper presents a description of Multiple Personality Disorder--its development, etiology, and presentation. The paper stresses the criteria for diagnosis that can help professionals to identify individuals at an early stage. An overview of treatment approaches and indications for hospitalization, length of treatment, and goals are also explained. PMID:7891008

  15. Olfaction in Multiple Sclerosis

    Microsoft Academic Search

    Khurshed A. Ansari

    1976-01-01

    Serial binary dilutions of amyl acetate and nitrobenzene were used in a double-blind test to determine olfactory acuity of 40 multiple sclerosis (MS) patients. Similar determinations were made on 24 age- and sex-matched controls. Results of repeated measurements on 18 patients indicated that the methodology was reliably reproducible. When mean olfactory threshold on MS patients was compared with that of

  16. Multiple Metal Resistant Transferable Phenotypes in Bacteria as Indicators of Soil Contamination with Heavy Metals (6 pp)

    Microsoft Academic Search

    Robert P. Ryan; David J. Ryan; David N. Dowling

    2005-01-01

    (14%) isolates resistant to zinc, copper, nickel, arsenic and cobalt and site B had no bacteria resistant to all five of these selected metals. The transferability of heavy metal resistance was investigated in the case of 60 multiple heavy metal resistant isolates taken from site A and 50 multiple resistance isolates from site B. Transfer was only detected in isolates

  17. ISIM3D: AN ANSI-C THREE-DIMENSIONAL MULTIPLE INDICATOR CONDITIONAL SIMULATION PROGRAM

    EPA Science Inventory

    The indicator conditional simulation technique provides stochastic simulations of a variable that (i) honor the initial data and (ii) can feature a richer family of spatial structures not limited by Gaussianity. he data are encoded into a series of indicators which then are used ...

  18. Testing congruence among multiple grazing indicators: a multi-site study across the Tibetan plateau

    NASA Astrophysics Data System (ADS)

    Wang, Yun; Lehnert, Lukas; Holzapfel, Maika; Schultz, Roland; Heberling, Gwendolyn; Görzen, Eugen; Meyer, Hanna; Seeber, Elke; Pinkert, Stefan; Ritz, Markus; Ansorge, Hermann; Bendix, Jörg; Seifert, Bernhard; Miehe, Georg; Long, Ruijun; Yang, Yongping; Wesche, Karsten

    2015-04-01

    Aim Animal husbandry is one of the most widespread land use types, and grazing is a key topic in grassland management. A wide range of indicators are employed in grazing assessments and they often yield widely differing estimates on the associated level of degradation threat. Covering Tibet as a large grassland region with long history of pastoralism, we selected representative indicators to test: (1) how grazing responses change along large-scale climatic gradients, and (2) whether their responses to both grazing intensities and local abiotic conditions are congruent. Location Tibetan Plateau Methods Biotic indicators including species and growth form compositions of vascular plants, richness and abundance of small mammals and ants, together with soil nutrients and field spectra were compared in pairs of high and low grazing intensity at 18 sites across large climatic gradients. Altitude, temperature, and precipitation were considered as potentially influential abiotic factors. Responses of indicators to grazing intensity and environmental gradients were explored by multivariate and univariate analyses. Results All indicators responded strongly to environmental changes, but the response patterns and the most influential abiotic factors varied among indicators. Grazing responses showed low overall congruence. Only vegetation cover, soil nutrient concentrations, and spectral indices were sensitive to grazing across large spatial scales. Grazing effects were significant only when local abiotic factors were taken into account. Main conclusions The results imply that grazing assessments require both appropriate indicators and local calibration. Overall, the threat of grassland degradation across the Tibetan Plateau is not as severe as is commonly assumed.

  19. An Evaluation of Multiple Single-Case Outcome Indicators Using Convergent Evidence Scaling

    ERIC Educational Resources Information Center

    McGill, Ryan J.; Busse, R. T.

    2014-01-01

    The purpose of this article is to evaluate the consistency of five single-case outcome indicators, used to assess response-to-intervention data from a pilot Tier 2 reading intervention that was implemented at an elementary school. Using convergent evidence scaling, the indicators were converted onto a common interpretive scale for each case…

  20. Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays

    PubMed Central

    Rampersad, Sephra N.

    2012-01-01

    Accurate prediction of the adverse effects of test compounds on living systems, detection of toxic thresholds, and expansion of experimental data sets to include multiple toxicity end-point analysis are required for any robust screening regime. Alamar Blue is an important redox indicator that is used to evaluate metabolic function and cellular health. The Alamar Blue bioassay has been utilized over the past 50 years to assess cell viability and cytotoxicity in a range of biological and environmental systems and in a number of cell types including bacteria, yeast, fungi, protozoa and cultured mammalian and piscine cells. It offers several advantages over other metabolic indicators and other cytotoxicity assays. However, as with any bioassay, suitability must be determined for each application and cell model. This review seeks to highlight many of the important considerations involved in assay use and design in addition to the potential pitfalls. PMID:23112716

  1. Comparison of drought indicators derived from multiple data sets over Africa

    NASA Astrophysics Data System (ADS)

    Naumann, G.; Dutra, E.; Barbosa, P.; Pappenberger, F.; Wetterhall, F.; Vogt, J. V.

    2014-05-01

    Drought monitoring is a key component to mitigate impacts of droughts. Lack of reliable and up-to-date precipitation data sets is a common challenge across the globe. This study investigates different data sets and drought indicators on their capability to improve drought monitoring in Africa. The study was performed for four river basins located in different climatic regions (the Oum er-Rbia in Morocco, the Blue Nile in eastern Africa, the Upper Niger in western Africa, and the Limpopo in southeastern Africa) as well as the Greater Horn of Africa. The five precipitation data sets compared are the ECMWF ERA-Interim reanalysis, the Tropical Rainfall Measuring Mission satellite monthly rainfall product 3B-43, the Global Precipitation Climatology Centre gridded precipitation data set, the Global Precipitation Climatology Project Global Monthly Merged Precipitation Analyses, and the Climate Prediction Center Merged Analysis of Precipitation. The set of drought indicators used includes the Standardized Precipitation Index, the Standardized Precipitation-Evaporation Index, and Soil Moisture Anomalies. A comparison of the annual cycle and monthly precipitation time series shows a good agreement in the timing of the rainy seasons. The main differences between the data sets are in the ability to represent the magnitude of the wet seasons and extremes. Moreover, for the areas affected by drought, all the drought indicators agree on the time of drought onset and recovery although there is disagreement on the extent of the affected area. In regions with limited rain gauge data the estimation of the different drought indicators is characterized by a higher uncertainty. Further comparison suggests that the main source of differences in the computation of the drought indicators is the uncertainty in the precipitation data sets rather than the estimation of the distribution parameters of the drought indicators.

  2. Bayesian sequential estimation and evaluation of process capability indices with multiple subsamples

    Microsoft Academic Search

    H. M. Zhu; K. M. Yu

    2008-01-01

    Process capability analysis is designed to estimate the proportion of parts that do not meet engineering requirements in a stable production process. Using process capability indices to quantify manufacturing process precision and performance is essential part of implementing any quality improvement program. In this paper, we proposed a Bayesian sequential approach to estimate and evaluate the process capability based on

  3. Weighting and Aggregation in Composite Indicator Construction: A Multiplicative Optimization Approach

    ERIC Educational Resources Information Center

    Zhou, P.; Ang, B. W.; Zhou, D. Q.

    2010-01-01

    Composite indicators (CIs) have increasingly been accepted as a useful tool for benchmarking, performance comparisons, policy analysis and public communication in many different fields. Several recent studies show that as a data aggregation technique in CI construction the weighted product (WP) method has some desirable properties. However, a…

  4. Robust heart rate estimation from multiple asynchronous noisy sources using signal quality indices and a Kalman filter.

    PubMed

    Li, Q; Mark, R G; Clifford, G D

    2008-01-01

    Physiological signals such as the electrocardiogram (ECG) and arterial blood pressure (ABP) in the intensive care unit (ICU) are often severely corrupted by noise, artifact and missing data, which lead to large errors in the estimation of the heart rate (HR) and ABP. A robust HR estimation method is described that compensates for these problems. The method is based upon the concept of fusing multiple signal quality indices (SQIs) and HR estimates derived from multiple electrocardiogram (ECG) leads and an invasive ABP waveform recorded from ICU patients. Physiological SQIs were obtained by analyzing the statistical characteristics of each waveform and their relationships to each other. HR estimates from the ECG and ABP are tracked with separate Kalman filters, using a modified update sequence based upon the individual SQIs. Data fusion of each HR estimate was then performed by weighting each estimate by the Kalman filters' SQI-modified innovations. This method was evaluated on over 6000 h of simultaneously acquired ECG and ABP from a 437 patient subset of ICU data by adding real ECG and realistic artificial ABP noise. The method provides an accurate HR estimate even in the presence of high levels of persistent noise and artifact, and during episodes of extreme bradycardia and tachycardia. PMID:18175857

  5. Suicidality and divalproex sodium: analysis of controlled studies in multiple indications

    Microsoft Academic Search

    Laura Redden; Yili Pritchett; Weining Robieson; Xenia Kovacs; Mary Garofalo; Katherine Tracy; Mario Saltarelli

    2011-01-01

    BACKGROUND: Recent analyses of antiepileptic drugs have indicated an increase in the risk of suicidality. The objective of this report was to provide clinical information and an independent meta-analysis of divalproex sodium and suicidality events by analyzing data from 13 placebo-controlled studies and 1 low-dose controlled study. METHODS: Adverse events considered to be possibly suicide related were identified using the

  6. Neural network models for earthquake magnitude prediction using multiple seismicity indicators.

    PubMed

    Panakkat, Ashif; Adeli, Hojjat

    2007-02-01

    Neural networks are investigated for predicting the magnitude of the largest seismic event in the following month based on the analysis of eight mathematically computed parameters known as seismicity indicators. The indicators are selected based on the Gutenberg-Richter and characteristic earthquake magnitude distribution and also on the conclusions drawn by recent earthquake prediction studies. Since there is no known established mathematical or even empirical relationship between these indicators and the location and magnitude of a succeeding earthquake in a particular time window, the problem is modeled using three different neural networks: a feed-forward Levenberg-Marquardt backpropagation (LMBP) neural network, a recurrent neural network, and a radial basis function (RBF) neural network. Prediction accuracies of the models are evaluated using four different statistical measures: the probability of detection, the false alarm ratio, the frequency bias, and the true skill score or R score. The models are trained and tested using data for two seismically different regions: Southern California and the San Francisco bay region. Overall the recurrent neural network model yields the best prediction accuracies compared with LMBP and RBF networks. While at the present earthquake prediction cannot be made with a high degree of certainty this research provides a scientific approach for evaluating the short-term seismic hazard potential of a region. PMID:17393560

  7. Challenges of Parenting Multiples

    MedlinePLUS

    ... Parenting Multiples There are many psychological, social, and economic issues associated with multiple pregnancies. These issues should be given the same amount of attention as the medical risks. Fertility treatment makes you ...

  8. Multiplication as Replication

    NSDL National Science Digital Library

    WNET

    2008-10-07

    Students build tables and use patterns as an introduction to multiplication. They are encouraged to use multiplication by 10 or 100 for larger values as the beginnings of commutativity and distribution are introduced.

  9. Depression and Multiple Sclerosis

    MedlinePLUS

    ... various forms is common during the course of multiple sclerosis. In fact, studies have suggested that clinical depression, ... is easy to understand how a diagnosis of multiple sclerosis, a chronic condition with the potential for progressing ...

  10. Delineating the hazard zone of multiple soil pollutants by multivariate indicator kriging and conditioned Latin hypercube sampling

    Microsoft Academic Search

    Hone-Jay Chu; Yu-Pin Lin; Cheng-Shin Jang; Tsun-Kuo Chang

    2010-01-01

    Soil pollution delineation is a difficult task because there may be multiple pollution sources and complex transport schemes. In this study, four heavy-metal concentrations, namely Cr, Cu, Ni, and Zn, were collected at 1082 sampling sites in central Taiwan. Conditioned Latin Hypercube Sampling (cLHS) is used to determine the most cost-effective sampling strategies for long-term monitoring of multiple heavy metals.

  11. Multiple Contraction Revisited

    Microsoft Academic Search

    Wolfgang Spohn

    \\u000a Multiple contraction consists in giving up several beliefs at once. The treatments of multiple contraction in AGM belief revision\\u000a theory have remained unsatisfactory. The paper proposes a clear, plausible, and general model for multiple contraction in\\u000a ranking-theoretic terms according to which multiple contraction turns out to reduce to single contractions. The belief set\\u000a multiply contracted by {A\\u000a 1, …, A

  12. Multiple-input multiple-output (MIMO) radar: performance issues

    Microsoft Academic Search

    K. W. Forsythe; D. W. Bliss; G. S. Fawcett

    2004-01-01

    The application of multiple-input multiple-output (MIMO) techniques to multistage radar offers a number of advantages, including improved resolution and sensitivity. Depending upon the radar's mode of operation, the array design and the environment, these advantages may or may not be significant. In this paper, a simple analytic model for ground moving target indicator (GMTI) radar detection is presented and its

  13. Systolic Modular Multiplication

    Microsoft Academic Search

    Colin D. Walter

    1993-01-01

    A systolic array for modular multiplication is presented using the ideally suited algorithm of P.L. Montgomery (1985). Throughput is one modular multiplication every clock cycle, with a latency of 2n+2 cycles for multiplicands having n digits. Its main use would be where many consecutive multiplications are done, as in RSA cryptosystems.

  14. Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer’s Disease

    PubMed Central

    O'Dwyer, Laurence; Lamberton, Franck; Bokde, Arun L. W.; Ewers, Michael; Faluyi, Yetunde O.; Tanner, Colby; Mazoyer, Bernard; O'Neill, Des; Bartley, Máiréad; Collins, D. Rónán; Coughlan, Tara; Prvulovic, David; Hampel, Harald

    2011-01-01

    The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, tract-based spatial statistics (TBSS) were performed on scans of 40 healthy elders, 19 non-amnestic MCI (MCIna) subjects, 14 amnestic MCI (MCIa) subjects and 9 AD patients. Significantly higher DA was found in MCIna subjects compared to healthy elders in the right posterior cingulum/precuneus. Significantly higher DA was also found in MCIa subjects compared to healthy elders in the left prefrontal cortex, particularly in the forceps minor and uncinate fasciculus. In the MCIa versus MCIna comparison, significantly higher DA was found in large areas of the left prefrontal cortex. For AD patients, the overlap of FA and DR changes and the overlap of FA and MD changes were seen in temporal, parietal and frontal lobes, as well as the corpus callosum and fornix. Analysis of differences between the AD versus MCIna, and AD versus MCIa contrasts, highlighted regions that are increasingly compromised in more severe disease stages. Microstructural damage independent of gross tissue loss was widespread in later disease stages. Our findings suggest a scheme where WM damage begins in the core memory network of the temporal lobe, cingulum and prefrontal regions, and spreads beyond these regions in later stages. DA and MD indices were most sensitive at detecting early changes in MCIa. PMID:21738785

  15. The Receiver Operational Characteristic for Binary Classification with Multiple Indices and Its Application to the Neuroimaging Study of Alzheimer’s Disease

    PubMed Central

    Wu, Xia; Li, Juan; Ayutyanont, Napatkamon; Protas, Hillary; Jagust, William; Fleisher, Adam; Reiman, Eric; Yao, Li; Chen, Kewei

    2014-01-01

    Given a single index, the receiver operational characteristic (ROC) curve analysis is routinely utilized for characterizing performances in distinguishing two conditions/groups in terms of sensitivity and specificity. Given the availability of multiple data sources (referred to as multi-indices), such as multimodal neuroimaging data sets, cognitive tests, and clinical ratings and genomic data in Alzheimer’s disease (AD) studies, the single-index-based ROC underutilizes all available information. For a long time, a number of algorithmic/analytic approaches combining multiple indices have been widely used to simultaneously incorporate multiple sources. In this study, we propose an alternative for combining multiple indices using logical operations, such as “AND,” “OR,” and “at least n” (where n is an integer), to construct multivariate ROC (multiV-ROC) and characterize the sensitivity and specificity statistically associated with the use of multiple indices. With and without the “leave-one-out” cross-validation, we used two data sets from AD studies to showcase the potentially increased sensitivity/specificity of the multiV-ROC in comparison to the single-index ROC and linear discriminant analysis (an analytic way of combining multi-indices). We conclude that, for the data sets we investigated, the proposed multiV-ROC approach is capable of providing a natural and practical alternative with improved classification accuracy as compared to univariate ROC and linear discriminant analysis. PMID:23702553

  16. The Empirical Power and Type I Error Rates of the GBT and [omega] Indices in Detecting Answer Copying on Multiple-Choice Tests

    ERIC Educational Resources Information Center

    Zopluoglu, Cengiz; Davenport, Ernest C., Jr.

    2012-01-01

    The generalized binomial test (GBT) and [omega] indices are the most recent methods suggested in the literature to detect answer copying behavior on multiple-choice tests. The [omega] index is one of the most studied indices, but there has not yet been a systematic simulation study for the GBT index. In addition, the effect of the ability levels…

  17. Multiple KRAS mutations in pancreatic adenocarcinoma: molecular features of neoplastic clones indicate the selection of divergent populations of tumor cells.

    PubMed

    Visani, Michela; de Biase, Dario; Baccarini, Paola; Fabbri, Carlo; Polifemo, Anna Maria; Zanini, Nicola; Pession, Annalisa; Tallini, Giovanni

    2013-12-01

    KRAS is one of the most common genes mutated in pancreatic adenocarcinoma. Multiple KRAS mutations may be detected within the same pancreatic adenocarcinoma, but it is usually unclear whether the different mutations represent biologically irrelevant molecular events or whether they indicate the coexistence of distinct sizable neoplastic clones within a given tumor. We identified a case of pancreatic adenocarcinoma with 5 different mutations in the KRAS gene and have been able to characterize the allelic distribution of the KRAS mutations and the size of the neoplastic clones using allele-specific locked nucleic acid polymerase chain reaction and next-generation sequencing (454 GS-Junior). The results indicate that the tumor is composed of 5 distinct cell populations: one is KRAS G12V mutated (~38% of neoplastic cells), the second is KRAS G12V in one allele and KRAS G12D in the other (~32%), the third is KRAS G12V in one allele and KRAS G12R in the other (~24%), and the fourth is KRAS G12V in one allele and KRAS G12C in the other (~6%). The fifth clone, representing a minority of neoplastic cells, has a KRAS Q61H mutation in addition to one of the above alterations. Microsatellite analysis identified mutation of the NR21 marker out of the 13 tested, indicating that the tumor has a defect in maintaining DNA integrity different from loss of conventional DNA mismatch repair. These results are consistent with the successive selection of divergent populations of tumor cells and underscore the relevance of nucleotide instability in pancreatic adenocarcinoma. PMID:23426962

  18. On Multiple-Layered Vortices

    NASA Technical Reports Server (NTRS)

    Rossow, Vernon J.

    2011-01-01

    As part of an ongoing effort to find ways to make vortex flow fields decompose more quickly, photographs and observations are presented of vortex flow fields that indicate the presence of multiple layers of fluid rotating about a common axis. A survey of the literature indicates that multiple-layered vortices form in waterspouts, tornadoes and lift-generated vortices of aircraft. An explanation for the appearance of multiple-layered structures in vortices is suggested. The observations and data presented are intended to improve the understanding of the formation and persistence of vortex flow fields.

  19. Long-Term Effects of the Family Bereavement Program on Multiple Indicators of Grief in Parentally Bereaved Children and Adolescents

    ERIC Educational Resources Information Center

    Sandler, Irwin N.; Ma, Yue; Tein, Jenn-Yun; Ayers, Tim S.; Wolchik, Sharlene; Kennedy, Cara; Millsap, Roger

    2010-01-01

    Objectives: This article reports on results from a randomized experimental trial of the effects of the Family Bereavement Program (FBP) on multiple measures of grief experienced by parentally bereaved children and adolescents over a 6-year period. Method: Participants were 244 youths (ages 8-16, mean age = 11.4 years) from 156 families that had…

  20. Multiple-Group Confirmatory Factor Analysis in R--A Tutorial in Measurement Invariance with Continuous and Ordinal Indicators

    ERIC Educational Resources Information Center

    Hirschfeld, Gerrit; von Brachel, Ruth

    2014-01-01

    Multiple-group confirmatory factor analysis (MG-CFA) is among the most productive extensions of structural equation modeling. Many researchers conducting cross-cultural or longitudinal studies are interested in testing for measurement and structural invariance. The aim of the present paper is to provide a tutorial in MG-CFA using the freely…

  1. Fun with Multiplication Facts

    NSDL National Science Digital Library

    Ms. Shields

    2007-10-25

    We are going to practice our multiplication facts by having fun in the jungle! Drummin Up Our Multiplication Facts will help Jungle Jim as he beats his drums to learn his facts After you have helped Jungle Jim with his drums, join Jungle Jim and the Monkeys of Monamona while Swinging with Fact Families Memorize Multiplication Facts for extra practice after you have helped Jungle Jim! ...

  2. [Clinical problems in multiple osteochondroma].

    PubMed

    Ham, S J John; de Lange, Jan; van der Zwan, Arnard L; Schaap, Gerard R; van der Woude, Henk-Jan; Heeg, Minne

    2012-01-01

    Multiple osteochondroma, also known as hereditary multiple exostoses, is a relatively rare genetic disorder characterized by the presence of multiple osteochondromas. The disease is frequently painful, with restriction of the activities of daily living, problems with carrying out an occupation and performance at school. In addition, characteristic skeletal deformities and postural abnormalities of the joints very frequently occur in patients with this disorder. Malignant transformation of osteochondroma to chondrosarcoma occurs in 1-5% of the patients with multiple osteochondroma. Treatment of patients with multiple osteochondromas must be tuned to the problems experienced by the patient. Symptomatic osteochondromas are often an indication for excision; knowledge of the natural progression of the abnormality is important in this. Periodical screening is essential: in children to prevent or correct deformity and postural abnormalities and in adults to detect and treat malignant transformation of osteochondroma at an early stage. PMID:22414670

  3. Using multiple chemical indicators to assess sources of nitrate and age of groundwater in a karstic spring basin

    USGS Publications Warehouse

    Katz, B.; Copeland, R.; Greenhalgh, T.; Ceryak, R.; Zwanka, W.

    2005-01-01

    Human health and ecological concerns have arisen due to a steady increase in nitrate-N concentrations during the past 40 years in Fannin Springs (0.3-4.7 mg/L), a regional discharge point with an average flow of >2.8 m3/second (>100 ft3/second) for water from the karstic Upper Floridan aquifer (UFA). Multiple chemical indicators (major dissolved species, 15N and 18O of nitrate, dissolved gases, 78 pesticides and degradates, and 67 organic compounds typically found in domestic and industrial wastewater) and transient tracers (3H/3He, chlorofluorocarbons [CFCs], sulfur hexafluoride [SF6]) were analyzed in water samples from nine wells along three transects and in spring water to assess groundwater age and potential contaminant sources. Land use is predominantly agricultural (52 percent) and forest (31 percent) in the 320 km2 (124 mi2) spring basin, which was delineated from a potentiometric-surface map of the UFA using high-resolution water-level data. Nitrate-N concentrations were highly variable in the oxic UFA and ranged from <0.02 to 4.7 mg/L. ?? 15N-NO3 values (3.4-9.9 per mil) indicated that nitrate contamination originated from inorganic sources (synthetic fertilizer) and organic sources (manure spreading or waste disposal). Higher nitrate concentrations and the younger age of spring water relative to water from upgradient wells indicate better communication with N sources at the surface. Apparent ages of groundwater correlated positively with well depth (P < 0.05) and were younger in water from wells nearer to the spring (<8 years) compared with other wells (10-50 years). Most transient tracer concentrations were consistent with binary mixing curves representing mixtures of water recharged during the past 10 years and older water (recharged before 1940). Young water mixing fractions ranged from 0.07 to 0.90. Trace levels of herbicides found in groundwater and spring water were indicative of applications for vegetative control in agricultural and other land-use types.

  4. Multiple Linear Regression

    NSDL National Science Digital Library

    Lacey, Michelle

    This site, created by Michelle Lacey of Yale University, gives an explanation, a definition and an example of multiple linear regression. Topics include: confidence intervals, tests of significance, and squared multiple correlation. While brief, this is still a valuable site for anyone interested in statistics.

  5. Constraining Multiple Grammars

    ERIC Educational Resources Information Center

    Hopp, Holger

    2014-01-01

    This article offers the author's commentary on the Multiple Grammars (MG) language acquisition theory proposed by Luiz Amaral and Tom Roeper in the present issue. Multiple Grammars advances the claim that optionality is a constitutive characteristic of any one grammar, with interlanguage grammars being perhaps the clearest examples of a…

  6. Orchestrating Multiple Intelligences

    ERIC Educational Resources Information Center

    Moran, Seana; Kornhaber, Mindy; Gardner, Howard

    2006-01-01

    Education policymakers often go astray when they attempt to integrate multiple intelligences theory into schools, according to the originator of the theory, Howard Gardner, and his colleagues. The greatest potential of a multiple intelligences approach to education grows from the concept of a profile of intelligences. Each learner's intelligence…

  7. Multiple antibiotic allergies.

    PubMed

    Harris, R J; Harris, R L

    1978-12-01

    A case of an 18-year-old woman with postoperative infectious complications and multiple antibiotic allergies is discussed. The case poses several problems: the selection of an appropriate antibiotic to combat the infection, the persistence of the infection, and the treatment of multiple allergic responses to each of the antibiotic agents chosen. PMID:281442

  8. Multiple intracranial enterogenous cysts

    Microsoft Academic Search

    T J Walls; D P Purohit; W S Aji; I S Schofield; D D Barwick

    1986-01-01

    The case of a 40-year-old woman with increasing ataxia is described. Although the clinical presentation and evoked response studies raised the possibility of multiple sclerosis, further investigation revealed multiple cystic intracranial lesions. Surgical excision of one of the lesions relieved the patient's symptoms. Histological examination revealed that this was an enterogenous cyst. Although single cysts of this type have rarely

  9. Hadron Multiplicities at HERMES

    E-print Network

    A. Hillenbrand; M. Hartig

    2007-11-24

    Hadron multiplicities of $\\pim$, $\\pip$, $\\km$ and $\\kp$ have been measured in the deep-inelastic scattering of 27.5 GeV positrons off a hydrogen target. The data used in this analysis have been collected during the 2000 HERA running period. The multiplicities were obtained for 0.15$$ = 2.5 GeV$^2$.

  10. The Multiple Tasks Test

    Microsoft Academic Search

    Bastiaan R Bloem; Vibeke V Valkenburg; Mathilde Slabbekoorn; Mirjam D Willemsen

    2001-01-01

    Simultaneous challenge of posture and cognition (‘dual tasks’) may predict falls better than tests of isolated components of postural control. We describe a new balance test (the Multiple Tasks Test, MTT) which (1) is based upon simultaneous assessment of multiple (>2) postural components; (2) represents everyday situations; and (3) can be applied by clinicians. Relevant risk factors for falls and

  11. Persistence of an Occlusion-Negative Recombinant Nucleopolyhedrovirus in Trichoplusia ni Indicates High Multiplicity of Cellular Infection

    Microsoft Academic Search

    JAMES C. BULL; H. C. J. Godfray; D. R. O'Reilly

    2001-01-01

    We use data from the serial passage of co-occluded recombinant Autographa californica nuclear polyhedrosis virus (AcMNPV) to estimate the viral multiplicity of infection of cells within infected insects. Co-occlusion, the incorporation of wild-type and mutant virus genomes in the same occlusion body, has been proposed as a strategy to deliver genetically modified viruses as insecticides in a way that contains

  12. Interactive Multiple Scale Small Multiples Andrew S. Forsberg

    E-print Network

    Laidlaw, David

    Interactive Multiple Scale Small Multiples Jian Chen * Andrew S. Forsberg * Sharon M. Swartz this data in a 3D environment, we designed a visualization technique called multiple scale small multiples (MSSM), in which each view behaves like an environment in itself. Aggregated multiple views can also

  13. Multiple food allergy.

    PubMed

    Speer, F

    1975-02-01

    This paper is devoted to a study of multiple food allergy, here defined as sensitivity to three or more foods. The purpose of the study is to report findings obtained from a study of 250 private patients and to show what type of persons develop this condition, how it affects them, and what their common allergens are. It was found that multiple food allergy occurs in both sexes and at all ages but is more common in boys than in girls and more common in women then in men. The clinical manifestations were much like those caused by the more familiar inhalant allergy but with a much more widespread constitutional disturbance. The great majority of patients (86%) also reacted to such air-borne allergens as molds, pollens, house dust, and animal epithelials. This indicates that food allergy and inhalant allergy are fundamentally the same phenomenon. The common food allergens were such everyday foods as milk, chocolate, corn, egg, tomato, peanut, and citrus fruits. PMID:1173207

  14. Multiple organ dysfunction syndrome.

    PubMed Central

    Murray, M. J.; Coursin, D. B.

    1993-01-01

    The multiple organ dysfunction syndrome (MODS), though newly described, has manifested itself in intensive care unit (ICU) patients for several decades. As the name implies, it is a syndrome in which more than one organ system fails. Failure of these multiple organ systems may or may not be related to the initial injury or disease process for which the patient was admitted to the ICU. MODS is the leading cause of morbidity and mortality in current ICU practice. While the pathophysiology of MODS is not completely known, much evidence indicates that, during the initial injury which precipitates ICU admission, a chain of events is initiated which results in activation of several endogenous metabolic pathways. These pathways release compounds which, in and of themselves, are usually cytoprotective. However, an over exuberant activation of these endogenous systems results in an inflammatory response which can lead to development of failure in distant organs. As these organs fail, they activate and propagate the systemic inflammatory response. No therapy has proven entirely efficacious at modulating this inflammatory response and the incidence and severity of MODS. In current ICU practice, treatment is focused on prevention and treating individual organ dysfunction as it develops. With increased understanding of the pathophysiology of MODS therapy will come newer modalities which inhibit or interfere with the propagation of the endogenous systemic inflammatory response. These newer therapies hold great promise and already some are undergoing clinical investigation. PMID:7825351

  15. Multiple Myeloma and Diabetes

    PubMed Central

    Issa, Zeinab A.; Zantout, Mira S.; Azar, Sami T.

    2011-01-01

    Multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10% of all hematologic cancers. It is characterized by accumulation of clonal plasma cells, predominantly in the bone marrow. The prevalence of type 2 diabetes is increasing; therefore, it is expected that there will be an increase in the diagnosis of multiple myeloma with concomitant diabetes mellitus. The treatment of multiple myeloma and diabetes mellitus is multifaceted. The coexistence of the two conditions in a patient forms a major challenge for physicians. PMID:22363889

  16. Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling.

    PubMed

    Zeis, T; Allaman, I; Gentner, M; Schroder, K; Tschopp, J; Magistretti, P J; Schaeren-Wiemers, N

    2015-08-01

    Emerging as an important correlate of neurological dysfunction in Multiple Sclerosis (MS), extended focal and diffuse gray matter abnormalities have been found and linked to clinical manifestations such as seizures, fatigue and cognitive dysfunction. To investigate possible underlying mechanisms we analyzed the molecular alterations in histopathological normal appearing cortical gray matter (NAGM) in MS. By performing a differential gene expression analysis of NAGM of control and MS cases we identified reduced transcription of astrocyte specific genes involved in the astrocyte-neuron lactate shuttle (ANLS) and the glutamate-glutamine cycle (GGC). Additional quantitative immunohistochemical analysis demonstrating a CX43 loss in MS NAGM confirmed a crucial involvement of astrocytes and emphasizes their importance in MS pathogenesis. Concurrently, a Toll-like/IL-1? signaling expression signature was detected in MS NAGM, indicating that immune-related signaling might be responsible for the downregulation of ANLS and GGC gene expression in MS NAGM. Indeed, challenging astrocytes with immune stimuli such as IL-1? and LPS reduced their ANLS and GGC gene expression in vitro. The detected upregulation of IL1B in MS NAGM suggests inflammasome priming. For this reason, astrocyte cultures were treated with ATP and ATP/LPS as for inflammasome activation. This treatment led to a reduction of ANLS and GGC gene expression in a comparable manner. To investigate potential sources for ANLS and GGC downregulation in MS NAGM, we first performed an adjuvant-driven stimulation of the peripheral immune system in C57Bl/6 mice in vivo. This led to similar gene expression changes in spinal cord demonstrating that peripheral immune signals might be one source for astrocytic gene expression changes in the brain. IL1B upregulation in MS NAGM itself points to a possible endogenous signaling process leading to ANLS and GGC downregulation. This is supported by our findings that, among others, MS NAGM astrocytes express inflammasome components and that astrocytes are capable to release Il-1? in-vitro. Altogether, our data suggests that immune signaling of immune- and/or central nervous system origin drives alterations in astrocytic ANLS and GGC gene regulation in the MS NAGM. Such a mechanism might underlie cortical brain dysfunctions frequently encountered in MS patients. PMID:25937052

  17. Multiple Intelligences and Business Diversity.

    ERIC Educational Resources Information Center

    Martin, Joyce

    2003-01-01

    Results from 97 business students with substantial work histories indicate that the Multiple Intelligence Preference Inventory gives a valid and reliable indication of their preferred intelligences. Awareness of these results is associated with assessments of self and others as knowledge sources. This information can help in recognizing,…

  18. Basic Multiple Regression

    NSDL National Science Digital Library

    Lowry, Richard, 1940-

    This page will perform basic multiple regression analysis for the case where there are several independent predictor variables, X1, X2, etc., and one dependent or criterion variable, Y. Requires import of data from a spreadsheet.

  19. Multiple Myeloma Research Foundation

    MedlinePLUS

    ... the information you need! MMRF CoMMunity Gateway Next KNOWLEDGE LEADS TO CURES. Stay informed with our newsletter. ... unacceptable. The model we have created for drug discovery and development is revolutionary. It brings multiple myeloma ...

  20. A Multiple Procedure DDT

    E-print Network

    Knight, Thomas

    1968-01-01

    This Memo. Describes a version of DDT used as the command level of the A.I. Group PDP-6 Time Sharing System (ITS). Special features include capability to handle multiple jobs, ability to stop open read or write references ...

  1. Marsh Geomorphology: Multiple methods

    E-print Network

    Savidge, Dana

    Marsh Geomorphology: Multiple methods: · RTK GPS pedestrian surveys · Single beam echo sounding · Multibeam echo sounding · RTK/single beam - 300,000 readings; multibeam - about 2,000,000 readings Purpose

  2. Rituximab and multiple sclerosis.

    PubMed

    Kitsos, Dimitrios K; Tsiodras, Sotirios; Stamboulis, Eleftherios; Voumvourakis, Konstantine I

    2012-01-01

    B lymphocytes seem to have a fundamental role in multiple sclerosis, acting as sensors, coordinators, and regulators of the immune response. Furthermore, they are important in activating T cells and they can mediate tissue injury through diverse mechanisms. Such findings have important therapeutic implications in autoimmune central nervous system diseases in a fashion similar to other autoimmune processes. The best known monoclonal antibody targeting B cells that has been used as a novel therapy for various autoimmune conditions, as well as multiple sclerosis, is rituximab. This review summarizes the available data on the role of B cell in multiple sclerosis and further reports on current knowledge on the B-cell-depleting monoclonal antibody rituximab, its mechanism of action, and its efficacy on multiple sclerosis. Data presented were categorized in 3 groups based on the nature of data presented (radiological, clinical, and immunological data). Both case-control studies and case reports were included, while table classification was in chronological order. PMID:22421587

  3. [Multiple myeloma stem cell].

    PubMed

    Hosen, Naoki

    2015-01-01

    Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells. MM patients harbor phenotypic CD19+ B cells expressing the immunoglobulin gene sequence and the idiotype unique to the individual myeloma clone. However, in most MM patients CD19+ clonotypic B cells do not reconstitute MM disease upon transplantation into immune-deficient mice. In the SCID-rab and SCID-hu models, which enable engraftment of human MM in vivo, CD19-CD38++ plasma cells engrafted and rapidly propagated MM. These results indicate that MM-initiating cells are derived from plasma cells, which are terminally differentiated cells. It should be now clarified whether all MM plasma cells can exert as MM-initiating cells when located in the appropriate niche or only distinct myeloma stem cells can propagate MM. PMID:25626303

  4. Cannabinoids and Multiple Sclerosis

    Microsoft Academic Search

    Roger G. Pertwee

    2007-01-01

    This review discusses clinical and preclinical evidence that supports the use of cannabinoid receptor agonists for the management\\u000a of multiple sclerosis. In addition, it considers preclinical findings that suggest that as well as ameliorating signs and\\u000a symptoms of multiple sclerosis, cannabinoid CB1 and\\/or CB2 receptor activation may suppress some of the pathological changes that give rise to these signs and

  5. Mobile multiple access study

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Multiple access techniques (FDMA, CDMA, TDMA) for the mobile user and attempts to identify the current best technique are discussed. Traffic loading is considered as well as voice and data modulation and spacecraft and system design. Emphasis is placed on developing mobile terminal cost estimates for the selected design. In addition, design examples are presented for the alternative techniques of multiple access in order to compare with the selected technique.

  6. Multiple chemical sensitivity (MCS)

    Microsoft Academic Search

    Christian Wolf

    1996-01-01

    Multiple Chemical Sensitivity (MCS) is a systemic disorder causing central nervous, irritative and gastrointestinal symptoms,\\u000a and can be included in the category of “idiopathic environmental intolerance” (IEI). This term describes phenomena with multiple,\\u000a recurrent symptoms associated with various environmental factors that are tolerated by most people without problems. Those\\u000a advocating these concepts attribute the symptoms to exogenous substances. Those opposing

  7. Multiple Time Dimensions

    E-print Network

    Steven Weinstein

    2008-12-19

    The possibility of physics in multiple time dimensions is investigated. Drawing on recent work by Walter Craig and myself, I show that, contrary to conventional wisdom, there is a well-posed initial value problem--deterministic, stable evolution--for theories in multiple time dimensions. Though similar in many ways to ordinary, single-time theories, multi-time theories have some rather intriguing properties which suggest new directions for the understanding of fundamental physics.

  8. Multiplication as Combinations

    NSDL National Science Digital Library

    WNET.org Education

    2006-01-01

    In this lesson plan students explore how to use multiplication to find the number of combinations possible in various situations. They follow the Cyberchase kids through two short videos as they explore creating a matrix and a tree diagram to solve the number of combinations; looking for patterns across data and leading to the conclusion that the same solutions could have been found through multiplication (counting principle). The lesson plan includes two student worksheets, two assessment options, and an answer key (rtf).

  9. Extramedullary multiple myeloma

    Microsoft Academic Search

    J. Renau-Piqueras; O. Wetter; F. Miragall; A. Miguel; Ch. Hertenstein; J. Cervera; D. Brandhorst

    1982-01-01

    Summary  A case of multiple myeloma with a mediastinal tumor and other unusual findings is described. The findings included the presence\\u000a of extramedullary tumor masses at multiple sites in addition to the medullary tumor and, more interestingly, the occurence\\u000a of pleural and peritoneal effusions. The plasma cells from these effusions were analyzed using stereological morphometric\\u000a methods. The plasma cells were also

  10. Pyrochemical multiplicity counter development

    SciTech Connect

    Langner, D.G.; Dytlewski, N.; Krick, M.S.

    1991-01-01

    Impure plutonium-bearing materials from pyrochemical processes often display both significant self-multiplication and variable ({alpha},n) reaction rates. Standard neutron coincidence counting techniques usually fail to accurately measure these materials. Neutron multiplicity counters measure the third moment of the neutron multiplicity distribution and thus make it possible to deduce the fertile plutonium mass of a sample even when both the self-multiplication and the ({alpha},n) reaction rate are unknown. A multiplicity counter suitable for measuring pyrochemical materials has been designed and built. This paper describes the results of characterization studies for the new counter. The counter consists of 126 helium-3 tubes arranged in 4 concentric rings in a polyethylene moderator; the average spacing between the tubes is 1.59 cm. The end plugs for the counter are made of graphite, and the 24.1- by 37.5-cm sample cavity is cadmium lined. The counter consists of two distinct halves from which the neutron counts are summed. The counter is capable of operation in either a freestanding mode with the two halves coupled together by an external cabinet or in a glove-box mode with the two halves placed around a glovebox well and then mated. For a {sup 252}Cf source centered in the sample cavity, the measured efficiency of the new multiplicity counter is 57.7% and its die-away time is 47.2{mu}s. 8 refs., 9 figs.

  11. Multiple Sclerosis Luminance Threshold and Measurements

    E-print Network

    Foster, David H.

    Multiple Sclerosis Luminance Threshold and Measurements of Temporal Characteristics of Vision indicates multiple sclerosis; ON, optic neuritis. Table 1.-Clinical Details of Patients Details of Eye In patient with multiple sclerosis (MS) and In normal control subjects. The Inten Itles of the tlmull used

  12. Optical-biophysical relationships and validation of MODIS vegetation indices with multiple fine spatial resolution data in semiarid rangelands

    NASA Astrophysics Data System (ADS)

    Gao, Xiang

    The vegetation index products from the Moderate Resolution Imaging Spectroradiometer (MODIS) are designed to provide consistent, spatial and temporal comparisons of global vegetation conditions. The objective of this dissertation was to validate the robustness and global implementation of two MODIS VI algorithms, including the normalized difference vegetation index (NDVI) and "enhanced" vegetation index (EVI). Their performances have been evaluated in: (1) the normalization of canopy background (brightness) variations and the extraction of biophysical parameters across different canopy structures; (2) the characterization of seasonal vegetation profiles (phenological, intra-annual); and (3) spatial and temporal discrimination of vegetation differences (inter-annual). The validation was accomplished through multiple means, including canopy radiative transfer models which were utilized to extract pure vegetation spectra and "true" VI value free of background contamination for varying canopy structures and vegetation amount. The experimental field- and airborne-based radiometry and satellite imagery at multiple spatial resolutions were also coupled and scaled-up for comparison with coarse spatial resolution MODIS VI products to quantify characteristics of semiarid rangeland vegetation. The results showed that NDVI was advantageous in yielding biophysical relationships applicable across varying canopy types, but required knowledge of soils for biophysical estimations. The EVI provided biophysical relationships sensitive to canopy structure, thus requiring knowledge of canopy type for biophysical assessments. The MODIS VI products were successfully validated, radiometrically, by coupling field and the MODLAND Quick Airborne Looks (MQUALS) observations to high spatial resolution imagery (AVIRIS and ETM+), and appeared robust across the two parallel sites for depicting their ecological equivalents. MODIS multitemporal VI profiles were able to depict phenological activity, length of the growing season, peak and onset of greenness, and leaf turnover. Among the sensors tested, spatial resolution was found to be most important for discriminating the major land cover subtypes within the two parallel semiarid rangelands, and spectral resolution had major effects on capturing seasonal contrast due to atmosphere influences. The validation strategy utilized in this study to successively aggregate the integrity-inherent multiple fine spatial resolution data to the coarse MODIS pixel sizes appeared to perform well, thus showing potentials in the validation of other satellite products.

  13. Multiple stage multiple filter hydrate store

    DOEpatents

    Bjorkman, Jr., Harry K. (Birmingham, MI)

    1983-05-31

    An improved hydrate store for a metal halogen battery system is disclosed which employs a multiple stage, multiple filter means or separating the halogen hydrate from the liquid used in forming the hydrate. The filter means is constructed in the form of three separate sections which combine to substantially cover the interior surface of the store container. Exit conduit means is provided in association with the filter means for transmitting liquid passing through the filter means to a hydrate former subsystem. The hydrate former subsystem combines the halogen gas generated during the charging of the battery system with the liquid to form the hydrate in association with the store. Relief valve means is interposed in the exit conduit means for controlling the operation of the separate sections of the filter means, such that the liquid flow through the exit conduit means from each of the separate sections is controlled in a predetermined sequence. The three separate sections of the filter means operate in three discrete stages to provide a substantially uniform liquid flow to the hydrate former subsystem during the charging of the battery system. The separation of the liquid from the hydrate causes an increase in the density of the hydrate by concentrating the hydrate along the filter means.

  14. Multiple determinations of sperm DNA fragmentation show that varicocelectomy is not indicated for infertile patients with subclinical varicocele.

    PubMed

    García-Peiró, Agustín; Ribas-Maynou, Jordi; Oliver-Bonet, María; Navarro, Joaquima; Checa, Miguel A; Nikolaou, Alexandros; Amengual, María J; Abad, Carlos; Benet, Jordi

    2014-01-01

    Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient's fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA) were performed on semen samples from sixty infertile patients with varicocele (15 clinical varicoceles, 19 clinical varicoceles after surgical treatment, 16 subclinical varicoceles, and 10 subclinical varicoceles after surgical treatment). TUNEL, SCD, and SCSA assays all showed substantial sperm DNA fragmentation levels that were comparable between subclinical and clinical varicocele patients. Importantly, varicocelectomy did improve sperm quality in patients with clinical varicocele; however, this was not the case in patients with subclinical varicocele. In summary, although infertile patients with clinical and subclinical varicocele have similar sperm DNA quality, varicocelectomy should only be advised for patients with clinical varicocele. PMID:24967335

  15. Multiple Determinations of Sperm DNA Fragmentation Show That Varicocelectomy Is Not Indicated for Infertile Patients with Subclinical Varicocele

    PubMed Central

    García-Peiró, Agustín; Ribas-Maynou, Jordi; Oliver-Bonet, María; Navarro, Joaquima; Checa, Miguel A.; Nikolaou, Alexandros; Amengual, María J.; Abad, Carlos; Benet, Jordi

    2014-01-01

    Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient's fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA) were performed on semen samples from sixty infertile patients with varicocele (15 clinical varicoceles, 19 clinical varicoceles after surgical treatment, 16 subclinical varicoceles, and 10 subclinical varicoceles after surgical treatment). TUNEL, SCD, and SCSA assays all showed substantial sperm DNA fragmentation levels that were comparable between subclinical and clinical varicocele patients. Importantly, varicocelectomy did improve sperm quality in patients with clinical varicocele; however, this was not the case in patients with subclinical varicocele. In summary, although infertile patients with clinical and subclinical varicocele have similar sperm DNA quality, varicocelectomy should only be advised for patients with clinical varicocele. PMID:24967335

  16. Detection of multiple enteric virus strains within a foodborne outbreak of gastroenteritis: an indication of the source of contamination.

    PubMed Central

    Gallimore, C. I.; Pipkin, C.; Shrimpton, H.; Green, A. D.; Pickford, Y.; McCartney, C.; Sutherland, G.; Brown, D. W. G.; Gray, J. J.

    2005-01-01

    An outbreak of acute gastroenteritis of suspected viral aetiology occurred in April 2003 in the British Royal Fleet Auxiliary ship (RFA) Argus deployed in the Northern Arabian Gulf. There were 37 cases amongst a crew of 400 personnel. Of 13 samples examined from cases amongst the crew, six enteric viruses were detected by reverse transcriptase polymerase chain reaction (RT-PCR). Five different viruses were identified including, three norovirus genotypes, a sapovirus and a rotavirus. No multiple infections were detected. A common food source was implicated in the outbreak and epidemiological analysis showed a statistically significant association with salad as the source of the outbreak, with a relative risk of 3.41 (95% confidence interval of 1.7-6.81) of eating salad on a particular date prior to the onset of symptoms. Faecal contamination of the salad at source was the most probable explanation for the diversity of viruses detected and characterized. PMID:15724709

  17. 1 Multiple String Alignment Efficient methods for multiple sequence

    E-print Network

    Gusfield, Daniel M.

    1 Multiple String Alignment Efficient methods for multiple sequence alignment with guaranteed error Multiple string (sequence) alignment is a difficult and important problem in computa- tional biology, where for evaluating the goodness of a multiple alignment, but no efficient methods are known which compute the optimal

  18. Aspirin and multiple sclerosis.

    PubMed

    Tsau, Sheila; Emerson, Mitchell R; Lynch, Sharon G; LeVine, Steven M

    2015-01-01

    Aspirin is widely used to lessen the risks of cardiovascular events. Some studies suggest that patients with multiple sclerosis have an increased risk for some cardiovascular events, for example, venous thromboembolism and perhaps ischemic strokes, raising the possibility that aspirin could lessen these increased risks in this population or subgroups (patients with limited mobility and/or antiphospholipid antibodies). However, aspirin causes a small increased risk of hemorrhagic stroke, which is a concern as it could potentially worsen a compromised blood-brain barrier. Aspirin has the potential to ameliorate the disease process in multiple sclerosis (for example, by limiting some components of inflammation), but aspirin also has the potential to inhibit mitochondrial complex I activity, which is already reduced in multiple sclerosis. In an experimental setting of a cerebral ischemic lesion, aspirin promoted the proliferation and/or differentiation of oligodendrocyte precursors, raising the possibility that aspirin could facilitate remyelination efforts in multiple sclerosis. Other actions by aspirin may lead to small improvements of some symptoms (for example, lessening fatigue). Here we consider potential benefits and risks of aspirin usage by patients with multiple sclerosis. PMID:26123634

  19. Prevalence of Exclusive Breastfeeding in Bangladesh and Its Association with Diarrhoea and Acute Respiratory Infection: Results of the Multiple Indicator Cluster Survey 2003

    Microsoft Academic Search

    Seema Mihrshahi; Naomi Ichikawa; Muhammad Shuaib; Wendy Oddy; Rose Ampon; Michael J. Dibley; Iqbal Kabir; Jennifer K. Peat

    The objective of this study was to investigate the association between the prevalence of exclusive breastfeeding and morbidity (diarrhoeal diseases and acute respiratory infection) in infants aged 0-3 month(s) using the Multiple Indicator Cluster Survey (MICS) 2003 data from Bangladesh. The study population included 1,633 infants aged 0-3 month(s). The prevalence of diarrhoea and acute respira- tory infection was compared

  20. Online multiple instance regression

    NASA Astrophysics Data System (ADS)

    Wang, Zhi-Gang; Zhao, Zeng-Shun; Zhang, Chang-Shui

    2013-09-01

    The multiple instance regression problem has become a hot research topic recently. There are several approaches to the multiple instance regression problem, such as Salience, Citation KNN, and MI-ClusterRegress. All of these solutions work in batch mode during the training step. However, in practice, examples usually arrive in sequence. Therefore, the training step cannot be accomplished once. In this paper, an online multiple instance regression method “OnlineMIR" is proposed. OnlineMIR can not only predict the label of a new bag, but also update the current regression model with the latest arrived bag. The experimental results show that OnlineMIR achieves good performances on both synthetic and real data sets.

  1. Multiple Meaning Words

    NSDL National Science Digital Library

    2013-01-28

    In this lesson, students will explore the concept that many words have multiple meaning. The students will be engaged in activities where they will use reference materials to look up the various definitions of the words and identify their parts of speech, as well as understand how the meaning of the words change depending on the context of the sentence. Students will compose sentences for words with multiple meanings, as well as write a riddle where both definitions of the word will help the reader solve the riddle. Students will work independently, as well as with their peers, in order gain a better understanding of multiple meaning words and how to identify their correct meanings using reference materials and context clues.

  2. Multiple sine, multiple elliptic gamma functions and rational cones

    E-print Network

    Tizzano, Luigi

    2015-01-01

    We define generalizations of the multiple elliptic gamma functions and the multiple sine functions, labelled by rational cones in $\\mathbb{R}^r$. For $r=2,3$ we prove that the generalized multiple elliptic gamma functions enjoy a modular property determined by the cone. This generalizes the modular properties of the elliptic gamma function studied by Felder and Varchenko. The generalized multiple sine enjoy a related infinite product representation, generalizing the results of Narukawa for the ordinary multiple sine functions.

  3. [Multiple intracranial arteriovenous malformation].

    PubMed

    Gelabert-González, Miguel; Santin-Amo, José María; Román-Pena, Paula; Vázquez Herrero, Fernando

    2015-01-01

    Multiple cerebral arteriovenous malformations (AVMs) are thought to be exceedingly rare lesions and have usually been reported as single cases. The incidence of multiple cerebral AVMs in major series ranges from 0.3% to 9% and, in the majority of cases, these malformations are associated with other vascular anomalies of the brain or soft tissues. We report a 62-year-old woman that presented with a left temporal haemorrhage. Angiography showed 3 AVMs located in the left temporal lobe, left cerebellar hemisphere and right temporal lobe. The lesions were treated with radiosurgery. PMID:25596643

  4. Multiple sort flow cytometer

    DOEpatents

    Van den Engh, Ger (Seattle, WA); Esposito, Richard J. (Seattle, WA)

    1996-01-01

    A flow cytometer utilizes multiple lasers for excitation and respective fluorescence of identified dyes bonded to specific cells or events to identify and verify multiple events to be sorted from a sheath flow and droplet stream. Once identified, verified and timed in the sheath flow, each event is independently tagged upon separation from the flow by an electrical charge of +60, +120, or +180 volts and passed through oppositely charged deflection plates with ground planes to yield a focused six way deflection of at least six events in a narrow plane.

  5. Factor-multiple Chains

    NSDL National Science Digital Library

    This problem offers opportunities for students to reinforce their understanding of factors and multiples and provides them the chance to justify their solutions. The goal is for the students to create number chains of four whole numbers that can range from 2 to 100 and each consecutive number is a multiple of the previous number. The Teachers' Notes page offers suggestions for implementation, key discussion questions, ideas for extension and support, and a link to a spreadsheet for students to experiment with placing numbers in specific boxes in the chain.

  6. Dimensions of multiple personality disorder.

    PubMed

    Murray, J B

    1994-06-01

    Research on multiple personality disorder (MPD) has burgeoned, and large-scale investigations indicate that a typical MPD patient is a woman, a victim of childhood abuse (especially sexual abuse), a person whose symptoms meet criteria for other psychiatric disorders, and a person who would employ many psychological defenses. Treatment approaches have frequently included hypnotherapy, which requires skill and caution. PMID:7931198

  7. Individual Differences and Multiple Intelligences.

    ERIC Educational Resources Information Center

    Fasko, Daniel, Jr.

    Recent educational research indicates that learners differ in their preferences for learning mode and strategies. Implications for instruction and assessment are discussed as they relate to the Theory of Multiple Intelligences of H. Gardner (1983). One of the principles of the "Learner Centered Psychological Principles" of the American…

  8. Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma.

    PubMed

    Isoda, Atsushi; Kaira, Kyoichi; Iwashina, Masanori; Oriuchi, Noboru; Tominaga, Hideyuki; Nagamori, Shushi; Kanai, Yoshikatsu; Oyama, Tetsunari; Asao, Takayuki; Matsumoto, Morio; Sawamura, Morio

    2014-11-01

    L-type amino-acid transporter 1 (LAT1) plays a key role in cell growth and survival. To determine the prognostic significance of LAT1 in multiple myeloma (MM), we investigated the expression of LAT1 and its functional subunit, 4Fc heavy chain (CD98), on myeloma cells by immunohistochemistry in 100 newly diagnosed MM patients. High expression (moderate or strong staining intensity) of LAT1 and CD98 was detected in 56% and 45% of patients, respectively. The LAT1 expression score was positively correlated with Ki-67 index (r = 0.631, P < 0.001), and there was a statistically significant difference in Durie-Salmon stage between patients with high and low LAT1 expression (P = 0.03). In 43 patients treated with melphalan and prednisolone, the overall response rate was significantly higher in the high LAT1 expression group (60.0%) than in the low LAT1 expression group (17.6%) (P = 0.03). Multivariate analysis confirmed that high expression of LAT1 was a significant prognostic factor for predicting poor overall survival independently from the International Staging System (both P = 0.01). Here, we show that the overexpression of LAT1 is significantly associated with high proliferation and poor prognosis in newly diagnosed MM patients. Thus, LAT1 may be a promising pathological marker for identifying high-risk MM. PMID:25220100

  9. Multiplicity description by gluon model

    E-print Network

    E. S. Kokoulina

    2015-04-07

    Study of high multiplicity events in proton-proton interactions is carried out at the U-70 accelerator (IHEP, Protvino). These events are extremely rare. Usually, Monte Carlo codes underestimate topological cross sections in this region. The gluon dominance model (GDM) was offered to describe them. It is based on QCD and a phenomenological scheme of a hadronization stage. This model indicates a recombination mechanism of hadronization and a gluon fission. Future program of the SVD Collaboration is aimed at studying a long-standing puzzle of excess soft photon yield and its connection with high multiplicity at the U-70 and Nuclotron facility at JINR, Dubna.

  10. Multiple impalement with survival

    Microsoft Academic Search

    Steven N Vaslef; Joel B Dragelin; Medhat W Takla; E. John Saliba

    1997-01-01

    An unusual case of multiple impalement by chain-link fence posts is presented in which facial, thoracic, and abdominal injuries were sustained following a rollover motor vehicle crash. Torso impalement injuries are briefly reviewed and guidelines for the management of such injuries are described.

  11. Multiple equilibrium laboratory devices

    NASA Astrophysics Data System (ADS)

    Whitehead, J. A.

    2001-12-01

    Devices{* } will be demonstrated and videotapes played of a number of laboratory studies that exhibit multiple equilibrium. All devices have two competing effects driving the flow. In two of them, temperature and salinity oppose each other. In another, air and water compete. In a fourth, wave propagation is opposed by inertia. Connection with hypothesized ocean behavior will be made. {* } Whitehead, J. A. 2000 Stratified Convection with Multiple States. Ocean Modelling, 2, 109-121. Whitehead, J. A. W. Gregory Lawson and John Salzig. 2001 Multistate flow devices for geophysical fluid dynamics and climate. American Journal of Physics, 69 546-553. Whitehead, J. A. and P. G. Baines. 2000. Hydraulic Jump Location as a Multiple Equilibrium feature. 2000 Ocean Sciences Meeting, American Geophysical Union, San Antonio Texas, January 25, 2000. Abstract: EOS 80 #46 (Supplement), OS125. Whitehead, J. A. , M. L. E. Timmermans, W. Gregory Lawson, S. N. Bulgakov, A. M. Zatarian, J. F. A. Medina, and John Salzig, Laboratory studies of thermally and/or Salinity-driven flows with partial mixing: Part 1 Stommel transitions and multiple flow states. In preparation

  12. Automatic multiple applicator electrophoresis

    NASA Technical Reports Server (NTRS)

    Grunbaum, B. W.

    1977-01-01

    Easy-to-use, economical device permits electrophoresis on all known supporting media. System includes automatic multiple-sample applicator, sample holder, and electrophoresis apparatus. System has potential applicability to fields of taxonomy, immunology, and genetics. Apparatus is also used for electrofocusing.

  13. ?Teriflunomide for multiple sclerosis.

    PubMed

    2014-07-01

    ?Teriflunomide (Aubagio-Genzyme Therapeutics), the main metabolite of the disease-modifying anti-rheumatic drug leflunomide,1 is an immunomodulatory agent with anti-inflammatory properties.2 It is a new oral treatment licensed for adults with relapsing-remitting multiple sclerosis. Here we discuss the evidence for its effectiveness and safety, and consider its place in therapy. PMID:25012149

  14. Polycrystal Plasticity -Multiple Slip"

    E-print Network

    Rollett, Anthony D.

    Polycrystal Plasticity - Multiple Slip" 27-750 Texture, Microstructure & Anisotropy A.D. Rollett;2 Objective" The objective of this lecture is to show how plastic deformation in polycrystals requires of Los Alamos polycrystal plasticity, LApp; also the Viscoplastic Selfconsistent code, VPSC; also

  15. 10monkeys Multiplication

    NSDL National Science Digital Library

    2013-07-03

    This free iOS app provides practice with multiplication facts in an arcade-like format. Students choose from among 10 levels (2 to 10 times tables and mixed times tables) and identify products of given factors in order to free trapped monkeys. Scoring rewards both accuracy and speed.

  16. Therapy of multiple personality

    Microsoft Academic Search

    Margaretta K. Bowers; Sylvia Brecher-marer; Bernauer W. Newton; Zygmunt Piotrowski; Thea C. Spyer; William S. Taylor; John G. Watkins

    1971-01-01

    In multiple personality, conflicting portions of the original personality have become 2 or more, largely disparate and autonomous personalities. Being a portion, each may be called a subpersonality. Of each 2 subpersonalities, at least one has some amnesia for the other.The therapist must be especially competent, particularly if he uses any hypnosis, deep analysis, or strong suggestion. He must avoid

  17. Unfolding Fraction Multiplication

    ERIC Educational Resources Information Center

    Wyberg, Terry; Whitney, Stephanie R.; Cramer, Kathleen A.; Monson, Debra S.; Leavitt, Seth

    2011-01-01

    Students often have difficulty understanding fractions, in general, and understanding how to multiply fractions, in particular. To move past this potential problem area, students need to develop a deeper understanding of multiplication and connect the ideas to fractions. In this article, the authors share their insights into teaching fraction…

  18. Multiplication in Newton's Principia

    E-print Network

    Jaroslaw Wawrzycki

    2012-09-24

    Newton in his Principia gives an ingenious generalization of the Hellenistic theory of ratios and inspired experimentally gives a tensor-like definition of multiplication of quantities measured with his ratios. An extraordinary feature of his definition is generality: namely his definition a priori allows non commutativity of multiplication of measured quantities, which may give a non-trivial linkage to experimental facts subject to quantum mechanics discovered some two hundred years later. Mathematical scheme he introduces with this ingenious definition is closely related to the contemporary approach in spectral geometry. His definition reveals in particular that commutativity of the multiplication of quantities with physical dimension has the status of experimental assumption and does not have to be fulfilled in reality, although neither the mathematical tools nor experimental evidence could allow Newton to carry out the case when the multiplication is noncommutative. We present a detailed analysis of his definition as well as a linkage to the theory of representations of algebras with involution (and with normal forms of von Neumann algebras and Jordan Banach algebras).

  19. Multiple Grammars and MOGUL

    ERIC Educational Resources Information Center

    Truscott, John

    2014-01-01

    Optionality is a central phenomenon in second language acquisition (SLA), for which any adequate theory must account. Amaral and Roeper (this issue; henceforth A&R) offer an appealing approach to it, using Roeper's Multiple Grammars Theory, which was created with first language in mind but which extends very naturally to SLA. They include…

  20. Combining Multiple Weak Clusterings

    Microsoft Academic Search

    Alexander P. Topchy; Anil K. Jain; William F. Punch

    2003-01-01

    A data set can be clustered in many ways depending on the clustering algorithm employed, parameter settings used and other factors. Can multiple clusterings be combined so that the final partitioning of data provides better clustering? The answer depends on the quality of clusterings to be combined as well as the properties of the fusion method. First, we introduce a

  1. Core Multiplication in Childhood

    ERIC Educational Resources Information Center

    McCrink, Koleen; Spelke, Elizabeth S.

    2010-01-01

    A dedicated, non-symbolic, system yielding imprecise representations of large quantities (approximate number system, or ANS) has been shown to support arithmetic calculations of addition and subtraction. In the present study, 5-7-year-old children without formal schooling in multiplication and division were given a task requiring a scalar…

  2. Effects of multiple interventions

    Microsoft Academic Search

    James Robins; Miguel Hernan; Uwe Siebert

    The purpose of this chapter is (i) to describe some currently available analytical methods for using individual level epidemiological data to estimate the impact of multiple risk factor interventions on health and (ii) to carefully review the conditions under which these methods deliver unbiased estimates of impact. The chapter is organized as follows. In sections 2 and 3, we discuss

  3. Multiple Choice Test

    NSDL National Science Digital Library

    Jay Parkes

    This site presents a guide to developing and deploying effective multiple choice tests. The site also discusses the costs and benefits of this method, as well as the philosophy of this commonly used assessment method. Links to more detailed information are included as well.

  4. Multiple Stakeholders and Evaluation.

    ERIC Educational Resources Information Center

    Eichelberger, R. Tony

    Evaluations occur within a political decision-making mileau, where multiple stakeholders are contending for limited funds. Given the subjective basis of empirical information, different conclusions or recommendations about a program may result from different ideological, theoretical, and disciplinary perspectives. The logic behind the…

  5. Immunotherapy for multiple myeloma.

    PubMed

    Rosenblatt, Jacalyn; Bar-Natan, Michal; Munshi, Nikhil C; Avigan, David E

    2014-02-01

    The potential potency of the immune system in targeting malignant plasma cells in multiple myeloma is best demonstrated in the allogeneic transplant setting, where durable responses can be achieved. However, allogeneic transplantation is associated with significant morbidity and mortality related to graft versus host disease, due to the non-specific nature of allo-reactive T cell responses mediated by donor lymphocytes. Immunotherapeutic approaches that more specifically target the malignant plasma cells have the potential to improve outcomes in multiple myeloma. The development of clinically efficacious immunotherapy in multiple myeloma is dependent on achieving a greater understanding of the complex interactions between the immunologic milieu and the growth of the malignant plasma cell clone. A number of antigens have been identified on malignant plasma cells that may be targeted by both humoral and cell mediated immunotherapeutic strategies. Encouraging results have been demonstrated both pre-clinically and in clinical trials. In this review, we summarize the clinical data evaluating immunotherapeutic approaches for the treatment of multiple myeloma. PMID:24417573

  6. IMMUNOLOGY OF MULTIPLE SCLEROSIS

    Microsoft Academic Search

    Mireia Sospedra; Roland Martin

    2005-01-01

    Ke yW ords autoimmunity, autoimmune mechanisms, neuroimmunology, demyelinating dieseases, EAE ? Abstract Multiple sclerosis (MS) develops in young adults with a complex pre- disposing genetic trait and probably requires an inciting environmental insult such as a viral infection to trigger the disease. The activation of CD4+ autoreactive T cells and their differentiation into a Th1 phenotype is a crucial event

  7. Multiple Docking Adapter Illustration

    NASA Technical Reports Server (NTRS)

    1972-01-01

    This cutaway drawing details the major characteristics of the Skylab Multiple Docking Adapter (MDA). The MDA, built under the direction of the Marshall Space Flight Center, housed the control units for the Apollo Telescope Mount (ATM), Earth Resources Experiment Package (EREP), and Zero-Gravity Materials Processing Facility, and provided a docking port for the Apollo Command Module (CM).

  8. A comparison of multiple indicator kriging and area-to-point Poisson kriging for mapping patterns of herbivore species abundance in Kruger National Park, South Africa

    PubMed Central

    Kerry, Ruth; Goovaerts, Pierre; Smit, Izak P.J.; Ingram, Ben R.

    2015-01-01

    Kruger National Park (KNP), South Africa, provides protected habitats for the unique animals of the African savannah. For the past 40 years, annual aerial surveys of herbivores have been conducted to aid management decisions based on (1) the spatial distribution of species throughout the park and (2) total species populations in a year. The surveys are extremely time consuming and costly. For many years, the whole park was surveyed, but in 1998 a transect survey approach was adopted. This is cheaper and less time consuming but leaves gaps in the data spatially. Also the distance method currently employed by the park only gives estimates of total species populations but not their spatial distribution. We compare the ability of multiple indicator kriging and area-to-point Poisson kriging to accurately map species distribution in the park. A leave-one-out cross-validation approach indicates that multiple indicator kriging makes poor estimates of the number of animals, particularly the few large counts, as the indicator variograms for such high thresholds are pure nugget. Poisson kriging was applied to the prediction of two types of abundance data: spatial density and proportion of a given species. Both Poisson approaches had standardized mean absolute errors (St. MAEs) of animal counts at least an order of magnitude lower than multiple indicator kriging. The spatial density, Poisson approach (1), gave the lowest St. MAEs for the most abundant species and the proportion, Poisson approach (2), did for the least abundant species. Incorporating environmental data into Poisson approach (2) further reduced St. MAEs. PMID:25729318

  9. Long-term Effects of the Family Bereavement Program on Multiple Indicators of Grief in Parentally Bereaved Children and Adolescents

    PubMed Central

    Sandler, Irwin N.; Ma, Yue; Tein, Jenn-Yun; Ayers, Tim S.; Wolchik, Sharlene; Kennedy, Cara L.; Millsap, Roger

    2009-01-01

    Objectives This paper reports on results from a randomized experimental trial of the effects of the Family Bereavement Program (FBP) on multiple measures of grief experienced by parentally-bereaved children and adolescents over a six year period of time. Method Participants were 244 youth (ages 8–16, mean age = 11.4 years) from 156 families that had experienced the death of a parent. The sample consisted of 53% boys; ethnicity was 67% non-Hispanic white and 33% ethnic minority. Families were randomly assigned to the FBP (N=135) or a literature control condition (N=109). Two grief measures, the Texas Revised Inventory of Grief (TRIG) and the Intrusive Grief Thoughts Scale (IGTS) were administered at four times over six years, pre-test, post-test, eleven-month and six-year follow-ups. A third measure, an adaptation of the Inventory of Traumatic Grief (ITG) was administered only at the six-year follow-up. Results The FBP showed a greater reduction as compared to controls in their level of problematic grief (IGTS) at post-test and six-year follow-up and in the percent at clinical levels of problematic grief at the post-test. The FBP also reduced scores on a dimension of the ITG, Social Detachment/Insecurity, at six-year follow-up for three subgroups; those who experienced lower levels of grief at program entry, older youth, and boys. Conclusion These are the first findings from a randomized trial with long-term follow-up of the effects of a program to reduce problematic levels of grief of parentally-bereaved youth. PMID:20350025

  10. Multiple gene analyses of caligid copepods indicate that the reduction of a thoracic appendage in Pseudocaligus represents convergent evolution

    PubMed Central

    2013-01-01

    Background The Caligidae is a family of parasitic copepods containing over 30 recognised genera. They are commercially important parasites as they cause disease in numerous finfish aquaculture facilities globally. Morphological features are used to distinguish between the genera and Pseudocaligus has traditionally been differentiated from Caligus solely by the presence of a much reduced form of the fourth thoracic leg. Currently there are numerous DNA sequences available for Caligus spp. but only the type species, Pseudocaligus brevipedis, has molecular data available, so systematic studies using molecular phylogenetic analyses have been limited. Methods Three gene regions, SSU rDNA, 16S and CO1, for Pseudocaligus fugu from puffer fish from Japan and Pseudocaligus uniartus from rabbit fish from Indonesia are sequenced and molecular phylogenetic analyses performed in order to infer phylogenetic relationships between Pseudocaligus and other caligid copepods. Results The analysis revealed that there was no discrete grouping of Pseudocaligus spp. and that they had a polyphyletic distribution within Caligus taxa. Pseudocaligus fugu grouped with Caligus elongatus and contained a unique synapomorphy in the SSU rDNA region only seen in members of that clade. Pseudocaligus uniartus formed a well-supported group, in the SSU rDNA analyses, with a Caligus sp. that also infects rabbit fish, but was unresolved in the other analyses. Pseudocaligus brevipedis consistently and robustly grouped with Caligus curtus and C. centrodonti in all analyses. The majority of Lepeophtheirus spp. form a monophyletic sister group to the Caligus clade; however, L. natalensis is unresolved in all analyses and does not form part of the main Lepeophtheirus clade. Conclusions These findings do not support the morphological-based distinction between Pseudocaligus and Caligus, suggesting that the reduced fourth leg is a feature that has evolved on multiple occasions throughout caligid evolution. Congruent molecular phylogenetic data support groupings based on the presence of morphological features, such as lunules, geography and host fish type rather than appendage morphology. Therefore, we support the synonymy of Pseudocaligus with Caligus. PMID:24286135

  11. Portable multiplicity counter

    DOEpatents

    Newell, Matthew R. (Los Alamos, NM); Jones, David Carl (Los Alamos, NM)

    2009-09-01

    A portable multiplicity counter has signal input circuitry, processing circuitry and a user/computer interface disposed in a housing. The processing circuitry, which can comprise a microcontroller integrated circuit operably coupled to shift register circuitry implemented in a field programmable gate array, is configured to be operable via the user/computer interface to count input signal pluses receivable at said signal input circuitry and record time correlations thereof in a total counting mode, coincidence counting mode and/or a multiplicity counting mode. The user/computer interface can be for example an LCD display/keypad and/or a USB interface. The counter can include a battery pack for powering the counter and low/high voltage power supplies for biasing external detectors so that the counter can be configured as a hand-held device for counting neutron events.

  12. Curability of Multiple Myeloma

    PubMed Central

    Alexanian, Raymond; Delasalle, Kay; Wang, Michael; Thomas, Sheeba; Weber, Donna

    2012-01-01

    Among 792 patients with multiple myeloma treated from 1987 to 2010 and assessed after 18 months, there were 167 patients with complete remission. For those 60 patients treated between 1987–1998 and with long followup, the latest relapse occurred after 11.8 years, so that 13 patients have remained in sustained complete remission for longer than 12 years (range 12–22 years). These results suggest that 3% of all patients treated during that period may be cured of multiple myeloma. In addition to immunofixation, more sensitive techniques for the detection of residual disease should be applied more consistently in patients with apparent complete remission in order to identify those with potential cure. PMID:22675638

  13. Core Multiplication in Childhood

    PubMed Central

    McCrink, Koleen; Spelke, Elizabeth S.

    2011-01-01

    A dedicated, non-symbolic, system yielding imprecise representations of large quantities (Approximate Number System, or ANS) has been shown to support arithmetic calculations of addition and subtraction. In the present study, 5–7-year-old children without formal schooling in multiplication and division were given a task requiring a scalar transformation of large approximate numerosities, presented as arrays of objects. In different conditions, the required calculation was doubling, quadrupling, or increasing by a fractional factor (2.5). In all conditions, participants were able to represent the outcome of the transformation at above-chance levels, even on the earliest training trials. Their performance could not be explained by processes of repeated addition, and it showed the critical ratio signature of the ANS. These findings provide evidence for an untrained, intuitive process of calculating multiplicative numerical relationships, providing a further foundation for formal arithmetic instruction. PMID:20537618

  14. Pediatric multiple sclerosis

    Microsoft Academic Search

    Brenda L. Banwell

    2004-01-01

    The onset of multiple sclerosis (MS) in childhood is being increasingly recognized. Despite this, there currently exist several\\u000a barriers to the prompt diagnosis of MS in children. Many clinicians view MS as an exclusively adult-onset disease, and thus\\u000a they may not entertain the diagnosis in a child. Also, the clinical and radiographic criteria for the diagnosis of MS have\\u000a not

  15. Clustering with Multiple Graphs

    Microsoft Academic Search

    Wei Tang; Zhengdong Lu; Inderjit S. Dhillon

    2009-01-01

    In graph-based learning models, entities are often represented as vertices in an undirected graph with weighted edges describing the relationships between entities. In many real-world application, however, entities are often associ- ated with relations of different types and\\/or from different sources, which can be well captured by multiple undirected graphs over the same set of vertices. How to exploit such

  16. Multiple membrane cavity optomechanics

    E-print Network

    M. Bhattacharya; P. Meystre

    2008-04-08

    We investigate theoretically the extension of cavity optomechanics to multiple membrane systems. We describe such a system in terms of the coupling of the collective normal modes of the membrane array to the light fields. We show these modes can be optically addressed individually and be cooled, trapped and characterized, e.g. via quantum nondemolition measurements. Analogies between this system and a linear chain of trapped ions or dipolar molecules imply the possibility of related applications in the quantum regime.

  17. Lipedema with multiple lipomas.

    PubMed

    Pascucci, Anabella; Lynch, Peter J

    2010-01-01

    Lipedema is an underdiagnosed syndrome of unclear etiology, characterized by symmetric painful enlargement of the buttocks and lower extremities, which spares the feet. This enlargement is caused by the deposition of adipose tissue. It was first described by Allen and Hines in 1940, who observed that it had a female predilection; patients commonly had an associated family history. We describe a patient with classic lipedema and multiple lipomas of her arms and trunk. PMID:20875325

  18. Multiple jet interactions 

    E-print Network

    Hehr, Roger James

    1983-01-01

    MULTIPLE JET INTERACTIONS A Thesis by ROGER JAMES HEHR Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August 1983 Major Subject: Aerospace Engineering... augmenting ejector systems in 3 such aircraft as the Mar1ne Corps/McDonnell Douglas AV-BB "Harrier". Schetz and Krzywoblocki present comprehensive reviews on the 2 4 works published concerning jets. The theoretical and experimental work relevant...

  19. Fatigue in multiple sclerosis

    Microsoft Academic Search

    Lauren B. Krupp; Christopher Christodoulou

    2001-01-01

    Fatigue is among the most common, yet least understood, symptoms of multiple sclerosis (MS) [1·]. It can profoundly disrupt\\u000a the occupational and social functioning of patients, and is recognized as a criterion for MS disability by the Social Security\\u000a Administration. Most approaches to fatigue assessment can be classified as either self-report scales or performance-based\\u000a measures of motor or cognitive output.

  20. Multiplication of Long Integers (Faster than Long Multiplication)

    E-print Network

    Mehlhorn, Kurt

    Kapitel 1 Multiplication of Long Integers (Faster than Long Multiplication) Arno Eigenwillig und Kurt Mehlhorn An algorithm for multiplication of integers is taught already in primary school is an example: 5 6 7 8 · 4 3 2 1 2 2 7 1 2 1 7 0 3 4 1 1 3 5 6 5 6 7 8 2 4 5 3 4 6 3 8 The multiplication

  1. Thread Organization and Matrix Multiplication matrix matrix multiplication

    E-print Network

    Verschelde, Jan

    Thread Organization and Matrix Multiplication 1 PyCUDA matrix matrix multiplication 2 Thread Multiplication L-32 4 April 2014 1 / 37 #12;about PyCUDA A. Klöckner, N. Pinto, Y. Lee, B. Catanzaro, P. Ivanov, and A. Fasih: PyCUDA and PyOpenCL: A scripting-based approach to GPU run-time code generation. Parallel

  2. Multiply with MI: Using Multiple Intelligences To Master Multiplication.

    ERIC Educational Resources Information Center

    Willis, Jody Kenny; Johnson, Aostre N.

    2001-01-01

    Explores how to use Gardner's Multiple Intelligence theory to help students' master multiplication. Focuses on helping children use their different intelligence strength to attain conceptual understanding of multiplication, develop their own thinking strategies for harder facts, and build mastery through practice and problem solving. (KHR)

  3. The Functions of Multiple Representations.

    ERIC Educational Resources Information Center

    Ainsworth, Shaaron

    1999-01-01

    Discusses multiple representations and multimedia learning environments; describes a functional taxonomy of MERs (multiple external representations); and considers how MERs are used to support cognitive processes in learning and problem solving with computers. (Contains 41 references.) (Author/LRW)

  4. Energy efficient multiple antenna communication

    E-print Network

    Ray, Siddharth, 1979-

    2006-01-01

    We consider a multiple-input, multiple-output (MIMO) wideband Rayleigh block fading channel where the channel state is unknown at the transmitter and receiver and there is only an average input power constraint. We compute ...

  5. Twins, Triplets, and Other Multiples

    MedlinePLUS

    ... what? Pregnancy This information in Spanish ( en español ) Twins, triplets, and other multiples How twins are formed ... can increase the likelihood of multiple births. How twins are formed Twins form in one of two ...

  6. Marijuana (Cannabis) and Multiple Sclerosis

    MedlinePLUS

    ... sativa — should be used for symptom management in multiple sclerosis (MS) is a complex one. It is generally ... pdf) Download Brochure Complementary and Alternative Medicine and Multiple Sclerosis (book) Find Book Massage and Bodywork Learn More ...

  7. State of the Art: Multiple Chemical Sensitivity

    Microsoft Academic Search

    Michael Lacour; Klaus Schmidtke; Peter Vaith; Carl Scheidt

    The ‘multiple chemical sensitivity syndrome’ (MCS) is defined descriptively as a (1) chronic condition (2) with symptoms that\\u000a recur reproducibly (3) in multiple organ systems (4) in response to low levels of exposures (5) to multiple unrelated chemicals\\u000a and which (6) improve or are resolved when incitants are removed. Patients' symptom profiles indicate that two different symptom\\u000a clusters exist with

  8. Multiplicity of Solutions in Aerodynamics

    NASA Technical Reports Server (NTRS)

    Dupont, M

    1927-01-01

    One of the most striking phenomena which accompany the flow of fluids such as air and water about bodies, is that of changes in character. This phenomena is still very little understood. We will first discuss the nature of these changes and then show that pure theory leads to a multiplicity of characters of flow, among which we will endeavor to indicate those bearing some analogy to experimental results.

  9. Achieving NTRU with Montgomery Multiplication

    E-print Network

    Achieving NTRU with Montgomery Multiplication Colleen O'Rourke and Berk Sunar, Member, IEEE Abstract--In this paper, we propose a new unified architecture that utilizes the Montgomery Multiplication algorithm to perform a modular multiplication for both integers and binary polynomials and NTRU's polynomial

  10. On the Essence of Multiplication.

    ERIC Educational Resources Information Center

    Boulet, Genevieve

    1998-01-01

    Presents and criticizes current theories of multiplication in order to pave the way for an alternative foundation for the concept of multiplication. Formulates a uniform concept of multiplication that recognizes anew the importance of the roles of multiplier and multiplicand. (Contains 22 references.) (ASK)

  11. Racial predilection in multiple sclerosis

    Microsoft Academic Search

    Milton Alter; Mary Harshe

    1975-01-01

    Comparisons between the geographic distribution of multiple sclerosis and the habitats of various racial groups showed that racial factors alone could not explain the increase in prevalence of the disease with latitude. Racially similar groups living in different areas had different frequencies of multiple sclerosis. Conversely, racially different groups, living in the same area, had similar prevalence rates of multiple

  12. Multiple Sclerosis and Vitamin D

    MedlinePLUS

    ... 2011;77;e99-e100 Neurology Andrew J. Solomon Multiple sclerosis and vitamin D This information is current as ... http://www.neurology.org//cgi/collection/multiple_sclerosis Multiple sclerosis s http://www.neurology.org//cgi/collection/all_demyelinating_ ...

  13. Constructing and Validating a Multiple-Indicator Construct of Economic Hardship in a National Sample of Adolescents with Disabilities

    ERIC Educational Resources Information Center

    Murray, Christopher; Doren, Bonnie; Gau, Jeff M.; Zvoch, Keith; Seeley, John R.

    2015-01-01

    The purpose of the current study was to develop a multi-indicator construct of economic hardship among adolescents with disabilities (N = 9,230) participating in the National Longitudinal Transition Study-2, the largest, most comprehensive investigation of adolescents with disabilities ever conducted. Five theoretically relevant indicators (i.e.,…

  14. Multiple Sparse Representations Classification

    PubMed Central

    Plenge, Esben; Klein, Stefan S.; Niessen, Wiro J.; Meijering, Erik

    2015-01-01

    Sparse representations classification (SRC) is a powerful technique for pixelwise classification of images and it is increasingly being used for a wide variety of image analysis tasks. The method uses sparse representation and learned redundant dictionaries to classify image pixels. In this empirical study we propose to further leverage the redundancy of the learned dictionaries to achieve a more accurate classifier. In conventional SRC, each image pixel is associated with a small patch surrounding it. Using these patches, a dictionary is trained for each class in a supervised fashion. Commonly, redundant/overcomplete dictionaries are trained and image patches are sparsely represented by a linear combination of only a few of the dictionary elements. Given a set of trained dictionaries, a new patch is sparse coded using each of them, and subsequently assigned to the class whose dictionary yields the minimum residual energy. We propose a generalization of this scheme. The method, which we call multiple sparse representations classification (mSRC), is based on the observation that an overcomplete, class specific dictionary is capable of generating multiple accurate and independent estimates of a patch belonging to the class. So instead of finding a single sparse representation of a patch for each dictionary, we find multiple, and the corresponding residual energies provides an enhanced statistic which is used to improve classification. We demonstrate the efficacy of mSRC for three example applications: pixelwise classification of texture images, lumen segmentation in carotid artery magnetic resonance imaging (MRI), and bifurcation point detection in carotid artery MRI. We compare our method with conventional SRC, K-nearest neighbor, and support vector machine classifiers. The results show that mSRC outperforms SRC and the other reference methods. In addition, we present an extensive evaluation of the effect of the main mSRC parameters: patch size, dictionary size, and sparsity level. PMID:26177106

  15. Multiple zeta values The Jackson integral

    E-print Network

    Baer, Christian

    Outline Multiple zeta values The Jackson integral q-multiple zeta values Multiple zeta values-9th 2013 D. Manchon Multiple zeta values and their q-analogues #12;Outline Multiple zeta values The Jackson integral q-multiple zeta values 1 Multiple zeta values Main properties Word description

  16. Factors and Multiples Puzzle

    NSDL National Science Digital Library

    This puzzle, played with cards on a board (downloadable file), provides an interesting context in which students can apply their knowledge of number properties. Students attempt to arrange 25 numbers and 10 property headings into a 5 by 5 grid so that each number satisfies two conditions. Properties addressed include primes, square and triangular numbers, specific sets of multiples and factors, and parity. It can be worked individually or in small groups cooperatively. The Teachers' Notes page offers suggestions for implementation, discussion questions, ideas for extension and support, and links to an article, "Using Games in the Classroom" (catalogued separately).

  17. Multiple jet interactions

    E-print Network

    Hehr, Roger James

    1983-01-01

    Multiple Jet Interactions. (August 1983) Roger James Hehr, B. S. , Texas A&M University Chairman of Advisory Committee: Dr. David J. Norton An experimental study to determine the effects of changing the nozzle separation ratio, h/D, of a linear array... of round jets on the veloc1ty field 40 nozzle diameters downstream of the nozzle exits was conducted. An init1al study of the individual jets comprisino the array was also conducted to provide a basis of comparison for future stud1es and for ver1ficat1...

  18. Multiplication Tables - Matching Cards

    NSDL National Science Digital Library

    This interactive Flash version of the familiar Concentration game ("pelmanism" in the UK) helps a single user practice multiplication facts while developing memory and concentration skills. The player can choose an array of 16, 20, or 24 cards, which appear face down. The goal is to flip two cards at a time to match all the pairs of factors with their products as efficiently as possible. A scoring feature discourages random guessing. Users can choose to work with factors in three ranges: 2x-10x, 2x-21x, or 11x-21x. Printable versions of the game cards are available to download.

  19. Recognizing multiple personality disorder.

    PubMed

    Curtin, S L

    1993-02-01

    1. It currently takes an average of 5 to 7 years and repeated hospitalizations for a person with multiple personality disorder (MPD) to be accurately diagnosed. 2. Reasons for misdiagnosis include the assumption that MPD is rare, the complex polysymptomatic presentation of the disorder, and failure of standard psychiatric histories to elicit pertinent diagnostic information. 3. Nurses are often the first to observe the behavioral, clinical, and physiological symptoms associated with MPD. 4. It is important to include questions that will elicit pertinent diagnostic information in the nursing history and assessment. As nurses become more adept at recognizing this disorder, individuals with MPD will receive more prompt and appropriate treatment. PMID:8437140

  20. Multiple personality disorder.

    PubMed

    Piper, A

    1994-05-01

    Five aspects of the diagnosis and treatment of multiple personality disorder (MPD) were examined. The following five conclusions were made: the contemporary diagnostic criteria are vague and overinclusive; the recent alleged increase in prevalence of the disorder is almost certainly artefactual; legal proceedings involving MPD patients raise disturbing questions about personal responsibility; there is little literature support for the theory that MPD results from childhood trauma; and many of the techniques used to diagnose and treat the condition reinforce its symptoms. A careful revision of diagnostic criteria for the disorder is recommended. PMID:7921709

  1. Complex Gaussian Multiplicative Chaos

    NASA Astrophysics Data System (ADS)

    Lacoin, Hubert; Rhodes, Rémi; Vargas, Vincent

    2015-07-01

    In this article, we study complex Gaussian multiplicative chaos. More precisely, we study the renormalization theory and the limit of the exponential of a complex log-correlated Gaussian field in all dimensions (including Gaussian Free Fields in dimension 2). Our main working assumption is that the real part and the imaginary part are independent. We also discuss applications in 2 D string theory; in particular we give a rigorous mathematical definition of the so-called Tachyon fields, the conformally invariant operators in critical Liouville Quantum Gravity with a c = 1 central charge, and derive the original KPZ formula for these fields.

  2. Multiple stars: designation, catalogues, statistics

    E-print Network

    A. Tokovinin

    2006-01-23

    Discussion of the designation of multiple-star components leads to a conclusion that, apart from components, we need to designate systems and centers-of-mass. The hierarchy is coded then by simple links to parent. This system is adopted in the multiple star catalogue, now available on-line. A short review of multiple-star statistics is given: the frequency of different multiplicities in the field, periods of spectroscopic sub-systems, relative orbit orientation, empirical stability criterion, and period-period diagram with its possible connection to formation of multiple stars.

  3. Phase-multiplication holography

    SciTech Connect

    Collins, H.D.; Prince, J.M.; Davis, T.J.

    1982-01-25

    This disclosure relates generally to nondestructive testing for identifying structural characteristics of an object by scanned holographic techniques using a known source of radiation, such as electromagnetic or acoustical radiation. It is an object of this invention to provide an apparatus and method for synthetic aperture expansion in holographic imaging applications to construct fringe patterns capable of holographic reproduction where aperture restrictions in nondestructive testing applications would conventionally make such imaging techniques impossible. The apparatus and method result in the production of a sharply defined frontal image of structural characteristics which could not otherwise be imaged because they occur either near the surface of the object or are confined by geometry restricting aperture dimensions available for scanning purposes. The depth of the structural characteristic below the surface of the object can also be determined by the reconstruction parameters which produce the sharpest focus. Lateral resolution is established by simulated reduction in the radiation wavelength and may easily be an order of magnitude less than the electromagnetic wavelength in the material or 2 times the standard depth of penetration. Since the phase multiplication technique is performed on the detected data, the penetration depth available due to the longer wavelength signals applied to the test object remains unchanged. The phase multiplication technique can also be applied to low frequency acoustic holography, resulting in a test which combines excellent penetration of difficult materials with high resolution images.

  4. Multiple Representations of Buoyancy

    NASA Astrophysics Data System (ADS)

    Oliviera, Jessica; Weglarz, Meredith; Vesenka, James

    2009-10-01

    For many students the concept of buoyancy falls under a category that can be loosely described as ``knowing it when they see it.'' Unfortunately some of the misconceptions this generates are that ``objects float because they are light'' and ``objects float because they are full of air'' [1]. Those these can some times be true, these descriptions are vague at best, and frequently can be wrong. Part of these misconceptions may stem from incomplete immersion of the object in the fluid and the vector nature of forces. We describe a demonstration/lab activity to help students make sense about relationship between the tension on and weight of an object immersed in water. The activity is in rich in multiple representations, graphical, diagrammatical as well as mathematical. A simple four question multiple choice pre/post test survey has been developed to evaluate the effectiveness of the lab activity.[4pt] [1] Bruce Harlan ``Diving Science'', www.stmatthewsschool.com/deep/pdfs/Diving%20Science.pdf

  5. Multiple symbol differential detection

    NASA Technical Reports Server (NTRS)

    Divsalar, Dariush (inventor); Simon, Marvin K. (inventor)

    1991-01-01

    A differential detection technique for multiple phase shift keying (MPSK) signals is provided which uses a multiple symbol observation interval on the basis of which a joint decision is made regarding the phase of the received symbols. In accordance with the invention, a first difference phase is created between first and second received symbols. Next, the first difference phase is correlated with the possible values thereof to provide a first plurality of intermediate output signals. A second difference phase is next created between second and third received symbols. The second difference phase is correlated with plural possible values thereof to provide a second plurality of intermediate output signals. Next, a third difference phase is created between the first and third symbols. The third difference phase is correlated with plural possible values thereof to provide a third plurality of intermediate output signals. Each of the first plurality of intermediate outputs are combined with each of the second plurality of intermediate outputs and each of the third plurality of intermediate outputs to provide a plurality of possible output values. Finally, a joint decision is made by choosing from the plurality of possible output values the value which represents the best combined correlation of the first, second and third difference values with the possible values thereof.

  6. Evaluation of the appropriateness of multiple symptom validity indices in psychotic and non-psychotic psychiatric populations.

    PubMed

    Schroeder, Ryan W; Marshall, Paul S

    2011-04-01

    Although it is recognized that significant cognitive deficits are inherent in many psychiatric disorders, there is minimal research on whether the deficits can cause a failing score on symptom validity tests (SVTs). The performances of 104 and 178 patients with psychotic disorders and non-psychotic psychiatric disorders, respectively, on seven SVTs were examined. Analyses indicate that most of these SVTs have specificity rates of 90% or better for both clinical groups. Further, only 7% of patients in the psychotic group and 5% of patients in the non-psychotic psychiatric group produced false-positive classifications based on malingering criteria similar to those suggested by Slick et al. (i.e., failure of two or more SVTs or failure of one SVT at statistically significantly worse than chance rates). Consequently this research indicates that psychiatric disorders typically do not adversely affect SVT performance. PMID:21391153

  7. Investigations of environmental conditions during cluster indicate probable vectors of unknown exogenous agent(s) of multiple sclerosis.

    PubMed

    McStreet, G H; Elkunk, R B; Latiwonk, Q I

    1992-01-01

    During the tail-end of an active cluster several environmental investigations indicated that wildbirds were very probably the vectors of the unknown exogenous agent of MS. Canine distemper and genetic-autoimmune theories were very definitely eliminated because of the unusual pattern of the cluster. Studies of several avian pathogens unveiled Marek's (MDV) and/or IBD (Gumboro) as the most likely candidates for exogenous agent of MS. PMID:1312422

  8. Bayes multiple decision functions

    PubMed Central

    Wu, Wensong; Peña, Edsel A.

    2014-01-01

    This paper deals with the problem of simultaneously making many (M) binary decisions based on one realization of a random data matrix X. M is typically large and X will usually have M rows associated with each of the M decisions to make, but for each row the data may be low dimensional. Such problems arise in many practical areas such as the biological and medical sciences, where the available dataset is from microarrays or other high-throughput technology and with the goal being to decide which among of many genes are relevant with respect to some phenotype of interest; in the engineering and reliability sciences; in astronomy; in education; and in business. A Bayesian decision-theoretic approach to this problem is implemented with the overall loss function being a cost-weighted linear combination of Type I and Type II loss functions. The class of loss functions considered allows for use of the false discovery rate (FDR), false nondiscovery rate (FNR), and missed discovery rate (MDR) in assessing the quality of decision. Through this Bayesian paradigm, the Bayes multiple decision function (BMDF) is derived and an efficient algorithm to obtain the optimal Bayes action is described. In contrast to many works in the literature where the rows of the matrix X are assumed to be stochastically independent, we allow a dependent data structure with the associations obtained through a class of frailty-induced Archimedean copulas. In particular, non-Gaussian dependent data structure, which is typical with failure-time data, can be entertained. The numerical implementation of the determination of the Bayes optimal action is facilitated through sequential Monte Carlo techniques. The theory developed could also be extended to the problem of multiple hypotheses testing, multiple classification and prediction, and high-dimensional variable selection. The proposed procedure is illustrated for the simple versus simple hypotheses setting and for the composite hypotheses setting through simulation studies. The procedure is also applied to a subset of a microarray data set from a colon cancer study. PMID:25414762

  9. Base rates, multiple indicators, and comprehensive forensic evaluations: why sexualized behavior still counts in assessments of child sexual abuse allegations.

    PubMed

    Everson, Mark D; Faller, Kathleen Coulborn

    2012-01-01

    Developmentally inappropriate sexual behavior has long been viewed as a possible indicator of child sexual abuse. In recent years, however, the utility of sexualized behavior in forensic assessments of alleged child sexual abuse has been seriously challenged. This article addresses a number of the concerns that have been raised about the diagnostic value of sexualized behavior, including the claim that when population base rates for abuse are properly taken into account, the diagnostic value of sexualized behavior is insignificant. This article also identifies a best practice comprehensive evaluation model with a methodology that is effective in mitigating such concerns. PMID:22339424

  10. Mutational Analysis of the Pullulanase-Type Debranching Enzyme of Maize Indicates Multiple Functions in Starch Metabolism

    PubMed Central

    Dinges, Jason R.; Colleoni, Christophe; James, Martha G.; Myers, Alan M.

    2003-01-01

    Plants contain two types of ?(1?6) glucan hydrolase (starch-debranching enzyme [DBE]). Mutations that affect the pullulanase-type DBE have not been described, although defects in isoamylase-type DBE, known in many plant species, indicate a function in starch biosynthesis. We describe a null mutation of a pullulanase-type DBE gene, a Mutator insertion in maize Zpu1. Plants homozygous for the zpu1-204 mutation are impaired in transient and storage starch degradation. Thus, hydrolytic activity of pullulanase-type DBE contributes to starch catabolism. Developing zpu1-204 endosperm accumulates branched maltooligosaccharides not found in the wild type and is deficient in linear maltooligosaccharides, indicating that the pullulanase-type DBE functions in glucan hydrolysis during kernel starch formation. Furthermore, in a background deficient in isoamylase-type DBE, zpu1-204 conditions a significant accumulation of phytoglycogen in the kernel that is not seen in the wild type. Therefore, pullulanase-type DBE partially compensates for the defect in isoamylase-type DBE, suggesting a function during starch synthesis as well as degradation. PMID:12615940

  11. Dancing with Multiple Partners

    NSDL National Science Digital Library

    Darren G. Woodside (Texas Biotechnology Corporation; REV)

    2002-03-19

    Transmembrane proteins, such as G protein-coupled receptors (GPCRs) and integrins, activate intracellular signaling pathways through interactions with downstream binding partners. Woodside discusses two examples in which GPCRs and integrins interact in a noncompeting manner with more than one partner. The specific GPCR described is the thrombin receptor, in experiments where G protein peptides selectively block signaling through a particular G protein that does not appear to inhibit coupling of the receptor to other G proteins. The second system described is the ?IIb?3 integrin and its activation of the nonreceptor tyrosine kinase Syk. Syk appeared capable of interacting with both the integrin and intracellular domains of immune response receptors, because binding of Syk to the integrin was not inhibited by peptides based on the Syk binding site in immune response receptors. Thus, multiple, noncompeting binding partners add to the complexity of signal transduction outputs from a single receptor complex.

  12. Pomalidomide for multiple myeloma.

    PubMed

    Fouquet, Guillemette; Bories, Claire; Guidez, Stéphanie; Renaud, Loïc; Herbaux, Charles; Javed, Sahir; Facon, Thierry; Leleu, Xavier

    2014-12-01

    Once characterized by a very poor outcome, multiple myeloma (MM) now has a significantly prolonged survival, with major improvements allowed by the use of 'novel agents': proteasome inhibitors (first-in-class bortezomib) and immunomodulatory compounds (IMiDs; first-in-class thalidomide and lenalidomide). However, the vast majority - if not all - of patients with MM ultimately end up being refractory to all existing drugs, including these efficient novel agents. There is a clear unmet medical need in this situation, which warrants the development of the next generation of proteasome inhibitors and IMiDs, as well as new drug classes. This drug profile focuses on pomalidomide, the next generation IMiD, recently approved by the US FDA and the EMA for patients with relapsed or refractory MM who have received at least two prior therapies, including lenalidomide and bortezomib, and have demonstrated disease progression on their last therapy. PMID:25265911

  13. Note on multiplicity

    E-print Network

    Katz, Daniel L.

    1988-12-01

    (/": yi) C\\ Ie = /n_1 for all n > c. Write / = Ei=0 riZ\\ in R[Z] and suppose / G (InR[Z]: g) n ICR[Z]. Then f ? 9 = -yiro + (x2ro ~ y\\ri)Z H-h (x2ra_i - yirs)Zs + x2rsZs+1. It follows that r0 G (In:yi) n Ie. Thus r0 G 7n_1, so x2r0 G /". This implies ri G... Philos. Soc. 57 (1961), 8-17. 7. D. Rees and R. Y. Sharp, On a theorem o¡ B. Teissier on multiplicities o¡ ideals in local rings, 3. London Math. Soc. 18 (1978), 449-463. 8. B. Teissier, Cycles evanescents, sections planes, et conditions de Whitney...

  14. Tremor in multiple sclerosis

    PubMed Central

    Mostert, Jop; Heersema, Dorothea; De Keyser, Jacques

    2007-01-01

    Tremor is estimated to occur in about 25 to 60 percent of patients with multiple sclerosis (MS). This symptom, which can be severely disabling and embarrassing for patients, is difficult to manage. Isoniazid in high doses, carbamazepine, propranolol and gluthetimide have been reported to provide some relief, but published evidence of effectiveness is very limited. Most trials were of small size and of short duration. Cannabinoids appear ineffective. Tremor reduction can be obtained with stereotactic thalamotomy or thalamic stimulation. However, the studies were small and information on long-term functional outcome is scarce. Physiotherapy, tremor reducing orthoses, and limb cooling can achieve some functional improvement. Tremor in MS remains a significant challenge and unmet need, requiring further basic and clinical research. PMID:17318714

  15. Multiple layer insulation cover

    DOEpatents

    Farrell, James J. (Livingston Manor, NY); Donohoe, Anthony J. (Ovid, NY)

    1981-11-03

    A multiple layer insulation cover for preventing heat loss in, for example, a greenhouse, is disclosed. The cover is comprised of spaced layers of thin foil covered fabric separated from each other by air spaces. The spacing is accomplished by the inflation of spaced air bladders which are integrally formed in the cover and to which the layers of the cover are secured. The bladders are inflated after the cover has been deployed in its intended use to separate the layers of the foil material. The sizes of the material layers are selected to compensate for sagging across the width of the cover so that the desired spacing is uniformly maintained when the cover has been deployed. The bladders are deflated as the cover is stored thereby expediting the storage process and reducing the amount of storage space required.

  16. Iterative relative fuzzy connectedness for multiple objects with multiple seeds q

    E-print Network

    Ciesielski, Krzysztof Chris

    Iterative relative fuzzy connectedness for multiple objects with multiple seeds q Krzysztof Chris, an object and a background, and each of the segments was indicated by a single seed. (See Udupa et al. [J, each segment can be indicated by more than one seed, which is often more natural and easier than

  17. Multiple Sensitive Periods in Human Visual Development

    E-print Network

    Maurer, Daphne M.

    by dense cataracts indicate that there are multiple sensitive periods during which experience can influence Wiley Periodicals, Inc. Dev Psychobiol 46: 163­183, 2005. Keywords: vision; congenital cataracts; sensitive period; plasticity; developmen- tal cataracts; visual deprivation; visual acuity, peripheral

  18. Current progress in using multiple electromagnetic indicators to determine location, time, and magnitude of earthquakes in California and Peru (Invited)

    NASA Astrophysics Data System (ADS)

    Bleier, T. E.; Dunson, C.; Roth, S.; Heraud, J.; Freund, F. T.; Dahlgren, R.; Bryant, N.; Bambery, R.; Lira, A.

    2010-12-01

    Since ultra-low frequency (ULF) magnetic anomalies were discovered prior to the 1989 Loma Prieta, Ca. M7.0 earthquake, QuakeFinder, a small R&D group based in Palo Alto California has systematically monitored ULF magnetic signals with a network of 3-axis induction magnetometers since 2000 in California. This raw magnetometer data was collected at 20-50 samples per sec., with no preprocessing, in an attempt to collect an accurate time history of electromagnetic waveforms prior to, during, and after large earthquakes within 30 km. of these sensors. Finally in October 2007, the QuakeFinder team observed a series of strange magnetic pulsations at the Alum Rock, California site, 14 days prior to M5.4 earthquake. These magnetic signals observed were relatively short, random pulsations, not continuous waveform signals like Pc1 or Pc3 micropulsations. The magnetic pulses have a characteristic uni-polar shapes and 0.5 sec. to 30 sec. durations, much longer than lightning signals. In May of 2010, very similar pulses were observed at Tacna, Peru, 13 days prior to a M6.2 earthquake, using a QuakeFinder station jointly operated under collaboration with the Catholic University in Lima Peru (PUCP). More examples of these pulsations were sought, and a historical review of older California magnetic data discovered fewer but similar pulsations occurred at the Hollister, Ca. site operated by UC Berkeley (e.g. San Juan Bautista M5.1 earthquake on August 12, 1998). Further analysis of the direction of arrival of the magnetic pulses showed an interesting “azimuth clustering” observed in both Alum Rock, Ca. and Tacna, Peru data. The complete time series of the Alum Rock data allowed the team to analyze subsequent changes observed in magnetometer “filter banks” (0.001 Hz to 10 Hz filter bands, similar to those used by Fraser-Smith in 1989), but this time using time-adjusted limits based on time of day, time of year, Kp, and site background noise. These site-customized limits showed similar increases in 30 minute averaged energy excursions, but the 30 minute averages had a disadvantage in that they reduced the signal to noise ratio over the individual pulse counting method. In other electromagnetic monitoring methods, air conductivity instrumentation showed major changes in positive air-borne ions observed near the Alum Rock and Tacna sites, peaking during the 24 hours prior to the earthquake. The use of GOES (geosynchronous) satellite infra red (IR) data showed that an unusual apparent “night time heating” occurred in an extended area within 40+ km. of the Alum Rock site, and this IR signature peaked around the time of the magnetic pulse count peak. The combination of these 3 indicators (magnetic pulse counts, air conductivity, and IR night time heating) may be the start in determining the time (within 1-2 weeks), location (within 20-40km) and magnitude (within +/- 1 increment of Richter magnitude) of earthquake greater than M5.4

  19. Multiple Membranes from Gauged Supergravity

    E-print Network

    Eric A. Bergshoeff; Mees de Roo; Olaf Hohm; Diederik Roest

    2008-08-26

    Starting from gauged N=8 supergravity in three dimensions we construct actions for multiple membranes by taking the limit to global supersymmetry for different choices of the embedding tensor. This provides a general framework that reproduces many recent results on multiple membrane actions as well as generalisations thereof. As examples we discuss conformal (non-conformal) gaugings leading to multiple M2-branes (D2-branes) and massive deformations of these systems.

  20. Multiple pathogens infect multiple hosts: Inference for incidence, infection, & impact

    E-print Network

    Wolpert, Robert L

    Multiple pathogens infect multiple hosts: Inference for incidence, infection, & impact #12;Nature · Competing species can coexist if each is attacked when it becomes abundant · Requires a different pathogen to regulate each host · If Janzen-Connell effects maintain diversity through pathogens, then ­ Pathogens

  1. Multiple pathogens infect multiple hosts: Inference for incidence, infection, & impact

    E-print Network

    Wolpert, Robert L

    Multiple pathogens infect multiple hosts: Inference for incidence, infection, & impact #12 a different pathogen to regulate each host · If Janzen-Connell effects maintain diversity through pathogens, then ­ Pathogens effects are host-specific (N pathogens for N hosts) ­ Strongest effect when host is abundant #12

  2. Multiple Imputation Strategies for Multiple Group Structural Equation Models

    Microsoft Academic Search

    Craig K. Enders; Amanda C. Gottschall

    2011-01-01

    Although structural equation modeling software packages use maximum likelihood estimation by default, there are situations where one might prefer to use multiple imputation to handle missing data rather than maximum likelihood estimation (e.g., when incorporating auxiliary variables). The selection of variables is one of the nuances associated with implementing multiple imputation, because the imputer must take special care to preserve

  3. Decisions and the Evolution of Memory: Multiple Systems, Multiple Functions

    E-print Network

    Cosmides, Leda

    information or knowledge. . . . Owners of biolog- ical memory systems are capable of behaving more: "Memory in biological systems always entails learning (the acquisition of information) and . . . learningDecisions and the Evolution of Memory: Multiple Systems, Multiple Functions Stanley B. Klein, Leda

  4. Disability in multiple sclerosis

    PubMed Central

    Chamot, Eric; Salter, Amber R.; Cutter, Gary R.; Bacon, Tamar E.; Herbert, Joseph

    2013-01-01

    Objective: To create a reference table of disability outcomes in multiple sclerosis (MS) that would enable patients to rank their disability relative to others' with similar disease duration and to develop a cost-effective research tool for comparing MS severity across patient populations and time periods. Methods: The North American Research Committee on Multiple Sclerosis (NARCOMS) Registry collects disability data from patients with MS on a validated, 9-point Patient-Determined Disease Steps (PDDS) scale. We compiled the Disability Expectancy Table, which displays cumulative frequencies of PDDS scores for each year of disease duration, from 0 to 45 years. We also tabulated disease duration–adjusted mean ranks of PDDS scores, referred to as Patient-derived MS Severity Scores (P-MSSS). Results: The cohort consisted of 27,918 NARCOMS enrollees, 72.7% of whom were female and 90.1% of whom were white. Mean age at symptom onset was 30.1 ± 10.1 years, and age at enrollment was 47.1 ± 11.0 years. The Disability Expectancy Table and P-MSSS afford a detailed overview of disability outcomes in a large MS cohort over a 45-year period. In the first year of disease, 15% of patients reported need of ambulatory aid, and 4% needed bilateral assistance or worse; after 45 years of disease, 76% of patients required ambulatory aid, and 52% bilateral assistance or worse. Proportion of patients who reported minimal or no interference in daily activities (PDDS ? 1) declined from 63% in the first year to 8% after 45 years of disease. Conclusion: The Disability Expectancy Table allows individual patients to determine how their disability ranks relative to NARCOMS enrollees with the same disease duration. P-MSSS may be used to compare disability across patient populations and to track disease progression in patient cohorts. P-MSSS does not require a formal neurologic examination and may therefore find wide applicability as a practical and cost-effective outcome measure in epidemiologic studies. PMID:23427319

  5. Multiple identity enactments and multiple personality disorder: a sociocognitive perspective.

    PubMed

    Spanos, N P

    1994-07-01

    People who enact multiple identities behave as if they possess 2 or more selves, each with its own characteristic moods, memories, and behavioral repertoire. Under different names, this phenomenon occurs in many cultures; in North American culture, it is frequently labeled multiple personality disorder (MPD). This article reviews experimental, cross-cultural, historical, and clinical findings concerning multiplicity and examines the implications of these findings for an understanding of MPD. Multiplicity is viewed from a sociocognitive perspective, and it is concluded that MPD, like other forms of multiplicity, is socially constructed. It is context bounded, goal-directed, social behavior geared to the expectations of significant others, and its characteristics have changed over time to meet changing expectations. PMID:8078970

  6. Multiple thermocouple testing device

    NASA Astrophysics Data System (ADS)

    Hildebrand, J. R.; Sobanski, K. J.

    1986-02-01

    An automated multiple thermocouple testing device determines short and open circuits in a thermocouple system. The thermocouple system that has a plurality of temperature probes, each probe has a first thermocouple. The device applies a direct current voltage to the first thermocouple to cause heating in the second thermocouple and a second thermocouple and then reads the temperature response of the second thermocouple. The first thermocouples have a common lead and the second thermocouples are connected in two parallel groups. The temperature output of the second thermocouple is digitized and read by a computer. These readings are compared to criteria which determine if there is an open circuit. Before the open circuit test is applied, the device also determines which thermocouple probe has a possible short circuit. This device can automatically test for short and open circuits in a thermocouple system within a few minutes without the necessity of removing the probes from their installed position. This device was adapted to perform the above testing on a F100 fan turbine inlet temperature (FTIT) system.

  7. “Undiagnosing” multiple sclerosis

    PubMed Central

    Klein, Eran P.; Bourdette, Dennis

    2012-01-01

    Objective: To describe the clinical characteristics of encounters with patients misdiagnosed with multiple sclerosis (MS). Methods: A cross-sectional Internet-based physician survey of MS specialists was performed. Results: The response rate for the survey was 50.4%. Of those who responded, the majority (95%) reported having evaluated 1 or more patients who had been diagnosed with MS, but who they strongly felt did not have MS, within the last year. The majority of respondents (>90%) also reported the use of disease-modifying therapy in a proportion of these patients. Most respondents (94%) found clinical encounters with these patients equally or more challenging than giving a new diagnosis of MS. Fourteen percent of respondents reported that they did not always inform such patients of their opinion that they did not have MS. Conclusions: The misdiagnosis of MS is common and has significant consequences for patient care and health care system costs. Caring for a patient with a misdiagnosis of MS is challenging, and at times honest disclosure of a misdiagnosis represents an important ethical concern for neurologists. More data are needed on this patient population to improve diagnostic acumen and the care of these patients. PMID:22581930

  8. Thermoregulation in multiple sclerosis.

    PubMed

    Davis, Scott L; Wilson, Thad E; White, Andrea T; Frohman, Elliot M

    2010-11-01

    Multiple sclerosis (MS) is a progressive neurological disorder that disrupts axonal myelin in the central nervous system. Demyelination produces alterations in saltatory conduction, slowed conduction velocity, and a predisposition to conduction block. An estimated 60-80% of MS patients experience temporary worsening of clinical signs and neurological symptoms with heat exposure. Additionally, MS may produce impaired neural control of autonomic and endocrine functions. This review focuses on five main themes regarding the current understanding of thermoregulatory dysfunction in MS: 1) heat sensitivity; 2) central regulation of body temperature; 3) thermoregulatory effector responses; 4) heat-induced fatigue; and 5) countermeasures to improve or maintain function during thermal stress. Heat sensitivity in MS is related to the detrimental effects of increased temperature on action potential propagation in demyelinated axons, resulting in conduction slowing and/or block, which can be quantitatively characterized using precise measurements of ocular movements. MS lesions can also occur in areas of the brain responsible for the control and regulation of body temperature and thermoregulatory effector responses, resulting in impaired neural control of sudomotor pathways or neural-induced changes in eccrine sweat glands, as evidenced by observations of reduced sweating responses in MS patients. Fatigue during thermal stress is common in MS and results in decreased motor function and increased symptomatology likely due to impairments in central conduction. Although not comprehensive, some evidence exists concerning treatments (cooling, precooling, and pharmacological) for the MS patient to preserve function and decrease symptom worsening during heat stress. PMID:20671034

  9. Immunopathogenesis of multiple sclerosis

    PubMed Central

    Racke, Michael K.

    2009-01-01

    Multiple sclerosis (MS) is a suspected autoimmune disease in which myelin-specific CD4+ and CD8+ T cells enter the central nervous system (CNS) and initiate an inflammatory response directed against myelin and other components of the CNS. Acute MS exacerbations are believed be the result of active inflammation, and progression of disability is generally believed to reflect accumulation of damage to the CNS, particularly axonal damage. Over the last several years, the pathophysiology of MS is being appreciated to be much more complex, and it appears that the development of the MS plaque involves a large number of cell populations, including CD8+ T lymphocytes, B cells, and Th17 cells (a population of helper T cells that secrete the inflammatory cytokine IL-17). The axonal transection and degeneration that is thought to represent the basis for progressive MS is now recognized to begin early in the disease process and to continue in the progressive forms of the disease. Molecules important for limiting aberrant neural connections in the CNS have been identified, which suppress axonal sprouting and regeneration of transected axons within the CNS. Pathways have also been identified that prevent remyelination of the MS lesion by oligodendrocyte precursors. Novel neuroimaging methodologies and potential biomarkers are being developed to monitor various aspects of the disease process in MS. As we identify the pathways responsible for the clinical phenomena of MS, we will be able to develop new therapeutic strategies for this disabling illness of young adults. PMID:20182567

  10. Using multiple chemical indicators to characterize and determine the age of groundwater from selected vents of the silver springs group, Central Florida, USA

    USGS Publications Warehouse

    Knowles, L., Jr.; Katz, B.G.; Toth, D.J.

    2010-01-01

    The Silver Springs Group, Florida (USA), forms the headwaters of the Silver River and supports a diverse ecosystem. The 30 headwater springs divide into five subgroups based on chemistry. Five selected spring vents were sampled in 2007 to better understand the contaminant sources and groundwater flow system. Elevated nitrate-N concentrations (>0.8mg/L) in the five spring vents likely originate from inorganic (fertilizers) and organic sources, based on nitrogen and oxygen isotope ratios of nitrate. Evidence for denitrification in the Lost River Boil spring includes enriched ??15N and ??18O, excess N2 gas, and low dissolved O2 concentrations (<0.5mg/L). Multiple age-tracer data (SF6, 3H, tritiogenic 3He) for the two uppermost springs (Mammoth East and Mammoth West) indicate a binary mixture dominated by recent recharge water (mean age 6-7 years, and 87-97% young water). Tracer data for the three downstream spring vents (Lost River Boil, Catfish Hotel-1, and Catfish Conventional Hall-1) indicate exponential mixtures with mean ages of 26-35 years. Contamination from non-atmospheric sources of CFCs and SF5CF3 precluded their use as age tracers here. Variations in chemistry were consistent with mean groundwater age, as nitrate-N and dissolved O2 concentrations were higher in younger waters, and the Ca/Mg ratio decreased with increasing mean age. ?? 2010 Springer-Verlag (outside the USA).

  11. Learning multiple layers of representation

    Microsoft Academic Search

    Geoffrey E. Hinton

    2007-01-01

    Abstract To achieve its’ impressive performance at tasks such as speech or object recognition, the brain extracts multiple levels of representation from the sensory input. Backpropagation was the first computation- ally efficient model of how neural networks could learn multiple layers of representation, but it required labeled training data and it did not work well in deep networks. The limitations

  12. Modular Inverse Algorithms without Multiplications

    Microsoft Academic Search

    Laszlo Hars

    2004-01-01

    the basic left-shift, right-shift and shifting Euclidean modular inverse algorithms are presented with new optimization tricks. These algorithms are based on the corresponding extended GCD algorithms, but only one multiplicator, the modular inverse is computed. On many computational platforms, for operand lengths used in cryptography, the fastest modular inverse algorithms need about twice the modular multiplication time, or even less.

  13. Multiple patterns of parental care

    Microsoft Academic Search

    James N. Webb; Alasdair I. Houston; John M. McNamara; TamáS SzéKely

    1999-01-01

    Many animals show multiple patterns of parental care, where more than one of the four basic patterns (biparental care, uniparental care by males or females, or no care) is present within a single population during a single breeding season. We consider three reasons for the existence of multiple patterns of parental care: (1) mixed-strategy behaviours; (2) time-dependent behaviour with parents

  14. Multiple chemical sensitivities: an overview

    Microsoft Academic Search

    Lawrence Fishbein

    1996-01-01

    At the present time multiple chemical sensitivities (MCS) is generally acknowledged to be a poorly understood clinical syndrome which is exhibited by individuals exposed to low levels of exposure to environmental agents that the general population tolerate quite well. A wide range of individual symptoms (typically multiple and related to neurologic, endocrine\\/metabolic, and immunological, often occurring simultaneously) are displayed by

  15. Global Optimization of Multiplicative Programs

    Microsoft Academic Search

    Hong-Seo Ryoo; Nikolaos V. Sahinidis

    2003-01-01

    This paper develops global optimization algorithms for linear multiplicative and generalized linear multiplicative programs based upon the lower bounding procedure of Ryoo and Sahinidis [30] and new greedy branching schemes that are applicable in the context of any rectangular branch-and-bound algorithm. Extensive computational results are presented on a wide range of problems from the literature, including quadratic and bilinear programs,

  16. Teaching for Mastery of Multiplication

    ERIC Educational Resources Information Center

    Wallace, Ann H.; Gurganus, Susan P.

    2005-01-01

    The strategies for learning multiplication concepts are discussed. The strategies involve introduction of the multiplication concepts through problem solutions with linkage between new concepts and prior knowledge, provision of concrete experiences and semi-concrete representations prior to purely symbolic notations, explicit teaching of the rules…

  17. Multiplication Fact Fluency Using Doubles

    ERIC Educational Resources Information Center

    Flowers, Judith M.; Rubenstein, Rheta N.

    2010-01-01

    Not knowing multiplication facts creates a gap in a student's mathematics development and undermines confidence and disposition toward further mathematical learning. Learning multiplication facts is a first step in proportional reasoning, "the capstone of elementary arithmetic and the gateway to higher mathematics" (NRC 2001, p. 242). Proportional…

  18. Introduction to Multiplication using Literature

    NSDL National Science Digital Library

    Scholastic

    2011-11-19

    This lesson plan can be used to introduce the concept of multiplication to students through the use of literature. The story Amanda Bean's Amazing Dream is used to demonstrate the different ways to count items and how multiplication can make that process much faster.

  19. Multiple strategy generation for wargaming

    Microsoft Academic Search

    Timothy Revello; Robert McCartney; Eugene Santos Jr.

    2004-01-01

    In this paper we present a framework for the automated generation of strategies that accounts for the multiple kinds of uncertainty found in war games, provides for a domain independent approach to strategy generation, and results in robust strategies. Our approach is to sample over multiple trials for varying victory conditions, different threat profiles, and variable system performance to achieve

  20. Symptomatic therapy in multiple sclerosis

    PubMed Central

    Frohman, Teresa C.; Castro, Wanda; Shah, Anjali; Courtney, Ardith; Ortstadt, Jeffrey; Davis, Scott L.; Logan, Diana; Abraham, Thomas; Abraham, Jaspreet; Remington, Gina; Treadaway, Katherine; Graves, Donna; Hart, John; Stuve, Olaf; Lemack, Gary; Greenberg, Benjamin; Frohman, Elliot M.

    2011-01-01

    Multiple sclerosis is the most common disabling neurological disease of young adults. The ability to impact the quality of life of patients with multiple sclerosis should not only incorporate therapies that are disease modifying, but should also include a course of action for the global multidisciplinary management focused on quality of life and functional capabilities. PMID:21694806

  1. Coloring Multiples in Pascal's Triangle

    NSDL National Science Digital Library

    2010-01-01

    In this activity, you will learn more about Pascal's Triangle! You will color numbers in Pascal's Triangle by rolling a number and then clicking on all entries that are multiples of the number rolled. This activity will allow you to practice multiplication tables, investigate number patterns, and investigate fractal patterns.

  2. Multiple personality disorder following childbirth.

    PubMed

    O'Dwyer, J M; Friedman, T

    1993-06-01

    A case of multiple personality disorder is described as a coping mechanism protecting the patient from the abuse to which she was subjected throughout her life. The multiple personalities became more prominent following the birth of a severely handicapped child. PMID:8330114

  3. Dynamics of multiple goal pursuit

    Microsoft Academic Search

    Maria J. Louro; Rik Pieters; Marcel Zeelenberg

    2007-01-01

    The authors propose and test a model of multiple-goal pursuit that specifies how individuals allocate effort among multiple goals over time. The model predicts that whether individuals decide to step up effort, coast, abandon the current goal, or switch to pursue another goal is determined jointly by the emotions that flow from prior goal progress and the proximity to future

  4. Multiple vehicle detection and tracking

    Microsoft Academic Search

    Margrit Betke; Esin Haritaoglu; Larry S. Davis

    1997-01-01

    A hard real time vision system has been developed that recognizes and tracks multiple cars from video sequences taken from a car driving on highways and country roads. Recognition is accomplished by combining the analysis of single image frames with the analysis of the motion information provided by multiple consecutive image frames. In single image frames, cars are recognized by

  5. Folklore and the Multiple Intelligences.

    ERIC Educational Resources Information Center

    Koehnecke, Dianne Swenson

    1995-01-01

    Explores using Howard Gardner's multiple intelligences for folklore analysis. States that when listening to folktales, linguistic intelligence was used, as opposed to drawing pictures of the stories, which used spatial intelligence. Provides some ideas on how to bring folklore studies and the use of multiple intelligences into the classroom. (PA)

  6. Undecidability of Multiplicative Subexponential Logic

    E-print Network

    Paris-Sud XI, Université de

    Undecidability of Multiplicative Subexponential Logic Kaustuv Chaudhuri INRIA, France kaustuv.chaudhuri@inria.fr [Presented at LINEARITY 2014, July 13, 2014] Abstract Subexponential logic is a variant of linear logic show that classical propositional multiplicative linear logic extended with one unrestricted and two

  7. Dissertationsthema Pseudo-multiplicative unitaries

    E-print Network

    Timmermann, Thomas

    Mathematik Dissertationsthema Pseudo-multiplicative unitaries and pseudo-Kac systems on C -modules¨ufung: 30.06.2005 Tag der Promotion: 13.07.2005 #12;Abstract We study pseudo-multiplicative unitaries and pseudo-Kac systems on C- modules in general and examples arising from locally compact groupoids in par

  8. Multiple fractional Fourier transform holography

    NASA Astrophysics Data System (ADS)

    Zeng, Yangsu; Zhang, Yixiao; Gao, Feng; Gao, Fuhua; Huang, Xiaoyang; Guo, Yongkang

    2002-04-01

    In this paper, we introduce the recording and reconstruction theories of the multiple fractional Fourier transform hologram (M-FRTH). We fabricated a multiple fractional Fourier transform hologram, and obtained satisfying reconstruction results. The experimental result shows that the M-FRTH has a high anti-counterfeiting capacity and can be used in the fabrication of the trademark, ID, and the notes.

  9. Multiplicity in Early Stellar Evolution

    E-print Network

    Reipurth, Bo; Boss, Alan P; Goodwin, Simon P; Rodriguez, Luis Felipe; Stassun, Keivan G; Tokovinin, Andrei; Zinnecker, Hans

    2014-01-01

    Observations from optical to centimeter wavelengths have demonstrated that multiple systems of two or more bodies is the norm at all stellar evolutionary stages. Multiple systems are widely agreed to result from the collapse and fragmentation of cloud cores, despite the inhibiting influence of magnetic fields. Surveys of Class 0 protostars with mm interferometers have revealed a very high multiplicity frequency of about 2/3, even though there are observational difficulties in resolving close protobinaries, thus supporting the possibility that all stars could be born in multiple systems. Near-infrared adaptive optics observations of Class I protostars show a lower binary frequency relative to the Class 0 phase, a declining trend that continues through the Class II/III stages to the field population. This loss of companions is a natural consequence of dynamical interplay in small multiple systems, leading to ejection of members. We discuss observational consequences of this dynamical evolution, and its influenc...

  10. Multiple Intracranial Aneurysms

    PubMed Central

    Mont’alverne, F.; Tournade, A.; Riquelme, C.; Musacchio, M.

    2002-01-01

    Summary We evaluate endovascular treatment (EVT) as an option to deal with multiple intracranial aneurysms(MA). From 1994 to 2001,24 patients underwent EVT for 59 MA. Patients were followed-up clinically and angiographically in a period ranging from 6 to 93 months (mean time of 22.2) and from 4 to 69 months (mean time of 19.3), respectively. Ten patients (41.6%) were treated either by EVT (n=7, 29,16%) or by mixed treatment (EVT and surgery; n=3, 12.5%). Reasons for treating just ruptured aneurysms: six (25%) had aneurysms smaller than 5 mm; three (12.5%) deaths; two (8.33%) were in the subacute period; two (8.33%) lost to follow-up; one (4.17%) authorised no procedure. No rebleeding was detected at the clinical follow-up, but there were five deaths. At immediate arteriographic control: 28 (85%) aneurysms were fully occluded, four (12%) with neck flow and one (03%) with sac flow. For 20 aneurysms followed-up: stability of occlusion was reached in seven cases (35%) and repermeabilization in 13 (65%). Management of recanalization was close arteriography in seven (54%), re-embolization in five (38%) and surgery in one (08%). When treating MA, EVT is advisable either alone or in mixed therapy. As a high degree of repermeabilization was disclosed, strict arteriographic control is required. The mechanisms underlying aneurysmal formation may be also involved in the recanalization phenomenon , a possible new manifestation of the fragility of the arterial wall. PMID:20594518

  11. Midkine and multiple sclerosis

    PubMed Central

    Takeuchi, Hideyuki

    2014-01-01

    Multiple sclerosis (MS) is an autoimmune neurological disease characterized by inflammatory demyelination with subsequent neuronal damage in the CNS. MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have been thought as autoreactive Th1 and Th17 cell-mediated diseases. CD4+CD25+FoxP3+ regulatory T-cell (Treg) plays a pivotal role in autoimmune tolerance, and tolerogenic dendritic cells (DCreg) drive the development of inducible Treg cells. Thus, a dysfunction in the development of Treg and DCreg leads to the development of autoimmune diseases. However, the factors that regulate Treg and DCreg are largely unknown. We recently showed that removal of midkine (MK) suppressed EAE due to an expansion of the Treg cell population as well as a decrease in the numbers of autoreactive Th1 and Th17 cells. MK decreased the Treg cell population by suppressing the phosphorylation of STAT5, which is essential for the expression of Foxp3, the master transcriptional factor of Treg cell differentiation. Furthermore, MK reduces the DCreg cell population by inhibiting the phosphorylation of STAT3, which is critical for DCreg development. Blockade of MK signalling by a specific RNA aptamer significantly elevated the population of DCreg and Treg cells and ameliorated EAE without detectable adverse effects. Therefore, the inhibition of MK may provide an effective therapeutic strategy against autoimmune diseases including MS. Linked Articles This article is part of a themed section on Midkine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-4 PMID:24460675

  12. Multiplicity among the young stars in Taurus

    NASA Technical Reports Server (NTRS)

    Simon, M.; Chen, W. P.; Howell, R. R.; Benson, J. A.; Slowik, D.

    1992-01-01

    Twenty-eight young stars systems in the northern Taurus star-forming region are surveyed for multiplicity. These observations, made by infrared lunar occultation and imaging techniques, can identify binaries in the angular separation range 0.005-10 arcsec. Of the 28 systems, 11 are binaries and two are triples, giving an observed multiplicity of 1.5 stars per system. The binary frequency and distribution of separations are similar to those of the main-sequence F and G spectral-type stars. Stars that have detected companions and those without are indistinguishable in H-alpha equivalent width, indicating that stars with active inner disks are represented in both groups. The multiple systems are in general weaker 1.3 mm continuum emitters than the single stars, indicating that the large-scale disks in these systems are less massive. However, there are important exceptions so the evolution of disks in multiple systems is not clear.

  13. Spearfishing Regulation Benefits Artisanal Fisheries: The ReGS Indicator and Its Application to a Multiple-Use Mediterranean Marine Protected Area

    PubMed Central

    Rocklin, Delphine; Tomasini, Jean-Antoine; Culioli, Jean-Michel; Pelletier, Dominique; Mouillot, David

    2011-01-01

    The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a marine protected area (MPA) and the benefit it provides for the local artisanal fishery through the use of a novel indicator. We analysed trends in the fish assemblage composition using artisanal fisheries data collected in the Bonifacio Strait Natural Reserve (BSNR), a Mediterranean MPA where the spearfishing activity has been forbidden over 15% of its area. Fish species were pooled into three response groups according to their target level by spearfishing. We developed the new flexible ReGS indicator reflecting shifts in species assemblages according to the relative abundance of each response group facing external pressure. The catch per unit effort (CPUE) increased by ca. 60% in the BSNR between 2000 and 2007, while the MPA was established in 1999. The gain of CPUE strongly depended on the considered response group: for the highly targeted group, the CPUE doubled while the CPUE of the untargeted group increased by only 15.5%. The ReGS value significantly increased from 0.31 to 0.45 (on a scale between 0 and 1) in the general perimeter of this MPA while it has reached a threshold of 0.43, considered as a reference point, in the area protected from spearfishing since 1982. Our results demonstrated that limiting recreational fishing by appropriate zoning in multiple-use MPAs represents a real benefit for artisanal fisheries. More generally we showed how our new indicator may reveal a wide range of impacts on coastal ecosystems such as global change or habitat degradation. PMID:21966357

  14. MULTIPLE ECH LAUNCHER CONTROL SYSTEM

    SciTech Connect

    GREEN,M.T; PONCE,D; GRUNLOH,H.J; ELLIS,R.A; GROSNICKLE,W.H; HUMPHREY,R.L

    2003-10-01

    OAK-B135 The addition of new, high power gyrotrons to the heating and current drive arsenal at DIII-D, required a system upgrade for control of fully steerable ECH Launchers. Each launcher contains two pointing mirrors with two degrees of mechanical freedom. The two flavors of motion are called facet and tilt. Therefore up to four channels of motion per launcher need to be controlled. The system utilizes absolute encoders to indicate mirror position and therefore direction of the microwave beam. The launcher movement is primarily controlled by PLC, but future iterations of design, may require this control to be accomplished by a CPU on fast bus such as Compact PCI. This will be necessary to accomplish real time position control. Safety of equipment and personnel is of primary importance when controlling a system of moving parts. Therefore multiple interlocks and fault status enunciators have been implemented. This paper addresses the design of a Multiple ECH Launcher Control System, and characterizes the flexibility needed to upgrade to a real time position control system in the future.

  15. Multiple-input, multiple-output pass transistor logic

    Microsoft Academic Search

    M. SHAMANNA; K. CAMERON; S. R. WHITAKER

    1995-01-01

    Techniques are presented for the design of multiple-input, multiple-output pass transistor circuits. By using shared functions as map-entered variables, dramatic reductions in transistor count can be achieved. Applied to a Viterbi decoder design for NASA, the transistor count of a CMOS integrated circuit was reduced by nearly 100000 transistors over the best previously known techniques. A proof is presented which

  16. Multiple-input-multiple-output measurements and modeling in Manhattan

    Microsoft Academic Search

    Dmitry Chizhik; Jonathan Ling; Peter W. Wolniansky; Reinaldo A. Valenzuela; Nelson Costa; Kris Huber

    2003-01-01

    Narrowband multiple-input-multiple-output (MIMO) measurements using 16 transmitters and 16 receivers at 2.11 GHz were carried out in Manhattan. High capacities were found for full, as well as smaller array configurations, all within 80% of the fully scattering channel capacity. Correlation model parameters are derived from data. Spatial MIMO channel capacity statistics are found to be well represented by the separate

  17. A Multiple Center Study of Multiple Chemical Sensitivity Syndrome

    Microsoft Academic Search

    D. J. Kutsogiannis; Ann L. Davidoff

    2001-01-01

    The lack of widely accepted, standardized, clinical and epidemiologic criteria for Multiple Chemical Sensitivity syndrome has led to confusion about the identification of the condition and has slowed pertinent research. In this article, the authors evaluated the psychometric properties of 2 sets of clinical\\/epidemiologic criteria for Multiple Chemical Sensitivity syndrome. In this cross-sectional survey of 1,166 patients who visited outpatient

  18. All About Multiplication: Modeling Multiplication with Rows and Columns

    NSDL National Science Digital Library

    Illuminations National Council of Teachers of Math

    2009-03-16

    "This lesson encourages students to explore the array model of multiplication. The lesson focuses on the factors 4 and 6. Students will also explore products with 0 or 1 as a factors. First students make arrays with counters, and then they create a second concrete example of the array model using toothpicks. They also write problems which involve multiplication." (from NCTM's Illuminations) This is lesson 3 in a 4-lesson unit.

  19. Phenomenology of high multiplicity events

    NASA Astrophysics Data System (ADS)

    Kokoulina, E. S.; SVD Collaboration

    2015-05-01

    Study of high multiplicity events in proton-proton (nucleus) interactions is carried out at U-70 accelerator of IHEP, Protvino. These events are extremely rare. Usually, MC codes underestimate topological cross sections in this region. Gluon dominance model has been offered to describe them. Some collective phenomena can be observed in high multiplicity events. SVD-2 Collaboration has obtained the evidence of pion condensate formation at high total multiplicity. Our future program is aimed at studying soft photon yield puzzle at U-70 and Nuclotronfacility at JINR, Dubna.

  20. Multiple polymersomes for programmed release of multiple components.

    PubMed

    Kim, Shin-Hyun; Shum, Ho Cheung; Kim, Jin Woong; Cho, Jun-Cheol; Weitz, David A

    2011-09-28

    Long-term storage and controlled release of multiple components while avoiding cross-contamination have potentially important applications for pharmaceuticals and cosmetics. Polymersomes are very promising delivery vehicles but cannot be used to encapsulate multiple independent components and release them in a controlled manner. Here, we report a microfluidic approach to produce multiple polymersomes, or polymersomes-in-polymersome by design, enabling encapsulation and programmed release of multiple components. Monodisperse polymersomes are prepared from templates of double-emulsion drops, which in turn are injected as the innermost phase to form the second level of double-emulsion drops, producing double polymersomes. Using the same strategy, higher-order polymersomes are also prepared. In addition, incorporation of hydrophobic homopolymer into the different bilayers of the multiple polymersomes enables controlled and sequential dissociation of the different bilayer membranes in a programmed fashion. The high encapsulation efficiency of this microfluidic approach, as well as its programmability and the biocompatibility of the materials used to form the polymersomes, will provide new opportunities for practical delivery systems of multiple components. PMID:21838246

  1. Correctly rounded multiplication by arbitrary precision constants

    E-print Network

    Brisebarre, Nicolas

    Correctly rounded multiplication by arbitrary precision constants J.-M. Muller Ar´enaire, LIP, ´E;Multiplications by constants Many numerical algorithms : multiplications by constants that are not exactly multiplications by constants. Correctly rounded multiplication by arbitrary precision constants 2/26 #12;Correctly

  2. Studies of porcine circovirus type 2, porcine boca-like virus and torque teno virus indicate the presence of multiple viral infections in postweaning multisystemic wasting syndrome pigs.

    PubMed

    Blomström, Anne-Lie; Belák, Sándor; Fossum, Caroline; Fuxler, Lisbeth; Wallgren, Per; Berg, Mikael

    2010-09-01

    In a previous study, using random amplification and large-scale sequencing technology, we identified a novel porcine parvovirus belonging to the genus Bocavirus in the background of porcine circovirus type 2 (PCV-2) in Swedish pigs with postweaning multisystemic wasting syndrome (PMWS). In addition to bocavirus we demonstrated the presence of torque teno virus (TTV) genogroups 1 and 2 in these cases of PMWS, indicating the simultaneous presence of several viruses in this disease complex. In the present study, 34 PMWS-affected animals and 24 pigs without PMWS were screened by PCR for the presence of PCV-2, TTV-1, TTV-2 and porcine boca-like virus (Pbo-likeV). The studies revealed the following infection rates in the PMWS-affected pigs: PCV-2 100%, TTV-1 77%, TTV-2 94% and Pbo-likeV 88%. In comparison, the pigs without PMWS had the following rates: PCV-2 80%, TTV-1 79%, TTV-2 83% and Pbo-likeV 46%. The sequence identity between the different Swedish Pbo-likeV sequences ranged between 98% and 100%. By checking co-infection, it was found that 71% of the PMWS-affected pigs harbor simultaneously all these viruses. As a contrast, in the group without PMWS only 33% of the animals were positive simultaneously for these viruses. These observations indicate a multiple viral infection in PMWS-affected pigs. It has to be studied further if the clinical manifestation of PMWS might be due to synergistic effects of different viruses acting together. PMID:20542066

  3. Multiple Regression and Its Discontents

    ERIC Educational Resources Information Center

    Snell, Joel C.; Marsh, Mitchell

    2012-01-01

    Multiple regression is part of a larger statistical strategy originated by Gauss. The authors raise questions about the theory and suggest some changes that would make room for Mandelbrot and Serendipity.

  4. Multiple tone operation of edgetones

    Microsoft Academic Search

    G. R. Stegen; K. Karamcheti

    1970-01-01

    Multiple tone operation of an edgetone is examined experimentally. It is shown that during stage 2 operation two discrete modes of operation may exist simultaneously. The second mode of operation is proven to be a persistence of stage 1 operation.

  5. LIDAR multiple scattering from clouds

    NASA Astrophysics Data System (ADS)

    Bissonnette, L. R.; Bruscaglioni, P.; Ismaelli, A.; Zaccanti, G.; Cohen, A.; Benayahu, Y.; Kleiman, M.; Egert, S.; Flesia, C.; Schwendimann, P.; Starkov, A. V.; Noormohammadian, M.; Oppel, U. G.; Winker, D. M.; Zege, E. P.; Katsev, I. L.; Polonsky, I. N.

    1995-04-01

    Multiple-scattering LIDAR return calculations obtained by seven different models for the same specified numerical experiment are compared. This work results from an international joint effort stimulated by the workshop group called MUSCLE for MUltiple SCattering Lidar Experiments. The models include approximations to the radiative-transfer theory, Monte-Carlo calculations, a stochastic model of the process of multiple scattering, and an extension of Mie theory for particles illuminated by direct and scattered light. The model solutions are similar in form but differ by up to a factor of 5 in the strength of the multiple-scattering contributions. Various reasons for the observed differences are explored and their practical significance is discussed.

  6. Genetics Home Reference: Multiple sclerosis

    MedlinePLUS

    ... The triggers of clinical attacks and remissions are unknown. After about 10 years, relapsing-remitting MS usually ... 1 in 20,000 people are affected. For unknown reasons, most forms of multiple sclerosis affect women ...

  7. Wearable multiple sensor acquisition device

    E-print Network

    Elledge, Christopher Lee, 1980-

    2003-01-01

    The wearable multiple sensor acquisition device is targeted as the primary sensor hub for the next revision of the MIThril wearable computer architecture. The device provides 3-axis acceleration sensing, infrared transmission ...

  8. [Fingolimod treatment in multiple sclerosis].

    PubMed

    Tanaka, Masami

    2014-11-01

    Multiple sclerosis (MS), an inflammatory disorder of the central nervous system, is characterized by relapsing-remitting (RR) clinical course. Fingolimod was the first oral therapy to prevent relapses in patients with RRMS, approved in Japan in 2011. In lymph node, fingolimod acts as functional antagonist, leading to internalization of sphingosine-1-phosphate 1(S1P1) receptors of lymphocytes. Lymphocytes in lymph nodes bearing S1P1 receptors cannot egress from lymph nodes. As a result, lymphocyte count in the circulation is reduced. Fingolimod showed reduced relapses, and suppressed the number of enhancing lesion and the progression of brain atrophy of brain MRI, however, it also showed some adverse effects such as bradycardia, herpes zoster infection, macular edema, liver dysfunction, and teratogenic properties. We proposed indications of fingolimod therapy, and reduced dosage therapy of fingolimod for patients with a lymphocyte count below 0.2 x 10(9) cells/L. PMID:25518386

  9. The MARVEL assembly for neutron multiplication

    SciTech Connect

    David L. Chichester; Mathew T. Kinlaw

    2013-10-01

    A new multiplying test assembly is under development at Idaho National Laboratory to support research, validation, evaluation, and learning. The item is comprised of three stacked, highly-enriched uranium (HEU) cylinders, each 11.4 cm in diameter and having a combined height of up to 11.7 cm. The combined mass of all three cylinders is 20.3 kg of HEU. Calculations for the bare configuration of the assembly indicate a multiplication level of >3.5 (keff=0.72). Reflected configurations of the assembly, using either polyethylene or tungsten, are possible and have the capability of raising the assembly's multiplication level to greater than 10. This paper describes simulations performed to assess the assembly's multiplication level under different conditions and describes the resources available at INL to support the use of these materials. We also describe some preliminary calculations and test activities using the assembly to study neutron multiplication.

  10. Interger multiplication with overflow detection or saturation

    SciTech Connect

    Schulte, M.J.; Balzola, P.I.; Akkas, A.; Brocato, R.W.

    2000-01-11

    High-speed multiplication is frequently used in general-purpose and application-specific computer systems. These systems often support integer multiplication, where two n-bit integers are multiplied to produce a 2n-bit product. To prevent growth in word length, processors typically return the n least significant bits of the product and a flag that indicates whether or not overflow has occurred. Alternatively, some processors saturate results that overflow to the most positive or most negative representable number. This paper presents efficient methods for performing unsigned or two's complement integer multiplication with overflow detection or saturation. These methods have significantly less area and delay than conventional methods for integer multiplication with overflow detection and saturation.

  11. Let's Practice Multiplication and Division!

    NSDL National Science Digital Library

    Miss Aycock

    2009-04-15

    Use the games below to improve your multiplication and division skills. Today, we are going to play some fun games that help us get better at multiplication and division. Follow the directions below: 1. Choose one of the following games. If you are a boy, you may wish to play with the catapult in Flight of the Knight. If you are a girl, you could ...

  12. Secure Sketch for Multiple Secrets

    Microsoft Academic Search

    Chengfang Fang; Qiming Li; Ee-Chien Chang

    2010-01-01

    \\u000a Secure sketches are useful in extending cryptographic schemes to biometric data since they allow recovery of fuzzy secrets\\u000a under inevitable noise. In practice, secrets derived from biometric data are seldom used alone, but typically employed in\\u000a a multi-factor or a multimodality setting where multiple secrets with different roles and limitations are used together. To\\u000a handle multiple secrets, we can generate

  13. Multiple Interactions in Pythia 8

    E-print Network

    Richard Corke

    2009-01-19

    Modelling multiple partonic interactions in hadronic events is vital for understanding minimum-bias physics, as well as the underlying event of hard processes. A brief overview of the current Pythia 8 multiple interactions (MI) model is given, before looking at two additional effects which can be included in the MI framework. With rescattering, a previously scattered parton is allowed to take part in another subsequent scattering, while with enhanced screening, the effects of varying initial-state fluctuations are modelled.

  14. Quantum spread spectrum multiple access

    E-print Network

    Juan Carlos Garcia-Escartin; Pedro Chamorro-Posada

    2014-11-27

    We describe a quantum multiple access scheme that can take separate single photon channels and combine them in the same path. We propose an add-drop multiplexer that can insert or extract a single photon into an optical fibre carrying the qubits of all the other users. The system follows the principle of code division multiple access, a spread spectrum technique widely used in cellular networks.

  15. Multiple imputation analysis of casecohort studies

    E-print Network

    Paris-Sud XI, Université de

    Multiple imputation analysis of casecohort studies Helena MARTI Biostatistics, CESP Centre de and multiple imputation 5 4 Validation of the method 8 4.1 Simulations casecohort studies rely on sometimes not fully ecient weighted estimators. Multiple imputation might

  16. Algorithms for Multiple Vehicle Routing Problems

    E-print Network

    Bae, Jung Yun

    2014-06-02

    is a multiple depot, multiple terminal, Hamiltonian Path problem. Given multiple vehicles starting at distinct depots, a set of targets and terminal locations, the objective of this problem is to find a vertex-disjoint path for each vehicle...

  17. Emotional Disorders in People with Multiple Sclerosis

    MedlinePLUS

    ... and their FAMILIES EMOTIONAL DISORDERS IN PEOPLE WITH MULTIPLE SCLEROSIS This fact sheet presents the current research on ... American Association of Neuroscience Nurses, the Consortium of Multiple Sclerosis Centers, and the International Organization of Multiple Sclerosis ...

  18. Quantifying the Relative Importance and Potential Interactive Effects of Multiple Indices When Predicting Fire Risk and Severity in the Western US.

    NASA Astrophysics Data System (ADS)

    Keyser, A. R.; Westerling, A.

    2007-12-01

    The national fire plan was implemented after the landmark fire season of 2000 as a response to a perceived increasing threat of severe wildfires. Subsequently, the Landfire project was initiated to develop a national dataset comprising vegetation condition, wildland fuels and fire regimes, and ecosystem status to support the national fire plan. A key product in this dataset to predict areas at risk for severe fires is the fire regime condition class (FRCC). The FRCC is an index of the degree of departure from the historical fire regime. This departure is a metric of the difference between current landscape vegetation composition and the range of historical reference vegetation characteristics; this difference can result from changes in vegetation characteristics and/or the spatial fire regime. The FRCC index is derived relative to simulated reference conditions, which in turn are based on Landsum, a landscape fire succession model. In addition to land management decisions, factors such as nitrogen deposition, ozone and climate affect both reference and current vegetation characteristics. It is an open question as to whether FRCC is sensitive enough to capture the full suite of potential effects on fire regimes. We are interested in examining vegetation change (via FRCC), nitrogen deposition, ozone concentration and climate variability in terms of their utility in predicting spatial variability in fire regime characteristics. Our analysis includes statistical examination of the multiple effects of nitrogen deposition, ozone, climate indices, and FRCC on fire frequency, size, and severity in California and the Western United States. We will assess how these four factors might act alone to influence fire, and their relative importance as co-determinants of fire risks. Our results will quantify how distinct FRCC is from climate and its efficacy as a predictor of fire risk and severity. Of particular interest is the extent to which FRCC predicts spatial variability in fire activity, and the extent to which climate and pollution patterns predict or influence the FRCC.

  19. Relationship of the Brief UCSD Performance-based Skills Assessment (UPSA-B) to multiple indicators of functioning in people with schizophrenia and bipolar disorder

    PubMed Central

    Mausbach, Brent T; Harvey, Philip D; Pulver, Ann E; Depp, Colin A; Wolyniec, Paula S; Thornquist, Mary H; Luke, James R; McGrath, John A; Bowie, Christopher; Patterson, Thomas L

    2010-01-01

    Objective This study assessed the relationship between multiple indicators of ‘real-world’ functioning and scores on a brief performance-based measure of functional capacity known as the Brief University of California San Diego (UCSD) Performance-based Skills Assessment (UPSA-B) in a sample of 205 patients with either serious bipolar disorder (n = 89) or schizophrenia (n = 116). Methods Participants were administered the UPSA-B and assessed on the following functional domains: (i) independent living status (e.g., residing independently as head of household, living in residential care facility); (ii) informant reports of functioning (e.g., work skills, daily living skills); (iii) educational attainment and estimated premorbid IQ as measured by years of education and Wide Range Achievement Test reading scores, respectively; and (iv) employment. Results Better scores on the UPSA-B were associated with greater residential independence after controlling for age, diagnosis, and symptoms of psychopathology. Among both bipolar disorder and schizophrenia patients, higher UPSA-B scores were significantly related to better informant reports of functioning in daily living skills and work skills domains. Greater estimated premorbid IQ was associated with higher scores on the UPSA-B for both schizophrenia and bipolar disorder participants. Participants who were employed scored higher on the UPSA-B when controlling for age and diagnosis, but not when controlling for symptoms of psychopathology. Conclusions These data suggest the UPSA-B may be useful for assessing capacity for functioning in a number of domains in both people diagnosed with schizophrenia and bipolar disorder. PMID:20148866

  20. NEW HAIL DIAGNOSTIC PARAMETERS DERVIED BY INTEGRATING MULTIPLE RADARS AND MULTIPLE SENSORS

    E-print Network

    Smith, Travis

    multiple-radars and multiple-sensors to rapidly prototype some new applications to diagnose hail in stormsP7.8 NEW HAIL DIAGNOSTIC PARAMETERS DERVIED BY INTEGRATING MULTIPLE RADARS AND MULTIPLE SENSORS. The ORPG is limited in that it cannot integrate data from multiple-radars or multiple-sensors

  1. Biological auctions with multiple rewards.

    PubMed

    Reiter, Johannes G; Kanodia, Ayush; Gupta, Raghav; Nowak, Martin A; Chatterjee, Krishnendu

    2015-08-01

    The competition for resources among cells, individuals or species is a fundamental characteristic of evolution. Biological all-pay auctions have been used to model situations where multiple individuals compete for a single resource. However, in many situations multiple resources with various values exist and single reward auctions are not applicable. We generalize the model to multiple rewards and study the evolution of strategies. In biological all-pay auctions the bid of an individual corresponds to its strategy and is equivalent to its payment in the auction. The decreasingly ordered rewards are distributed according to the decreasingly ordered bids of the participating individuals. The reproductive success of an individual is proportional to its fitness given by the sum of the rewards won minus its payments. Hence, successful bidding strategies spread in the population. We find that the results for the multiple reward case are very different from the single reward case. While the mixed strategy equilibrium in the single reward case with more than two players consists of mostly low-bidding individuals, we show that the equilibrium can convert to many high-bidding individuals and a few low-bidding individuals in the multiple reward case. Some reward values lead to a specialization among the individuals where one subpopulation competes for the rewards and the other subpopulation largely avoids costly competitions. Whether the mixed strategy equilibrium is an evolutionarily stable strategy (ESS) depends on the specific values of the rewards. PMID:26180069

  2. Subpixel resolution from multiple images

    NASA Technical Reports Server (NTRS)

    Cheeseman, Peter; Kanefsky, Rob; Stutz, John; Kraft, Richard

    1994-01-01

    Multiple images taken from similar locations and under similar lighting conditions contain similar, but not identical, information. Slight differences in instrument orientation and position produces mismatches between the projected pixel grids. These mismatches ensure that any point on the ground is sampled differently in each image. If all the images can be registered with respect to each other to a small fraction of a pixel accuracy, then the information from the multiple images can be combined to increase linear resolution by roughly the square root of the number of images. In addition, the gray-scale resolution of the composite image is also improved. We describe methods for multiple image registration and combination, and discuss some of the problems encountered in developing and extending them. We display test results with 8:1 resolution enhancement, and Viking Orbiter imagery with 2:1 and 4:1 enhancements.

  3. Multiplicity of chemically peculiar stars

    E-print Network

    S. Hubrig; N. Ageorges; M. Schoeller

    2005-10-11

    Recently, with the goal to study multiplicity of chemically peculiar stars, we carried out a survey of 40 stars using diffraction limited near infrared (IR) imaging with NAOS-CONICA (NACO) at the VLT. Here, we announce the detection of 27 near IR companion candidates around 25 late B-type chemically peculiar stars exhibiting strong overabundances of the chemical elements Hg and Mn in their atmospheres. A key point for the understanding of the abundance patterns in these stars may be connected with binarity and multiplicity. It is intriguing that more than half of the sample of HgMn stars studied previously by speckle interferometry and recently using the adaptive optics system NACO belong to multiple systems.

  4. Convergence and Discriminant: Assessing Multiple Traits Using Multiple Methods

    ERIC Educational Resources Information Center

    Pae, Hye K.

    2012-01-01

    Multiple traits of language proficiency as well as test method effects were concurrently analyzed to investigate interrelations of construct validity, convergent validity, and discriminant validity using multitrait-multimethod (MTMM) matrices. A total of 585 test takers' scores were derived from the field test of the "Pearson Test of English…

  5. Multiple-Symbol Detection Of Multiple-Trellis-Coded MDPSK

    NASA Technical Reports Server (NTRS)

    Divsalar, Dariush; Simon, Marvin K.; Shahshahani, Mehrdad M.

    1991-01-01

    In proposed scheme for detection and decoding of multiple-trellis-coded multilevel differential-phase-shift-keyed (MDPSK) radio signals, observation time for differential detection extended from conventional 2 to larger number of symbol periods. Decreases rate of error in differential detection of uncoded MDPSK by increasing number of symbol periods.

  6. Multiple Imputation Strategies for Multiple Group Structural Equation Models

    ERIC Educational Resources Information Center

    Enders, Craig K.; Gottschall, Amanda C.

    2011-01-01

    Although structural equation modeling software packages use maximum likelihood estimation by default, there are situations where one might prefer to use multiple imputation to handle missing data rather than maximum likelihood estimation (e.g., when incorporating auxiliary variables). The selection of variables is one of the nuances associated…

  7. Gd[subscript 13]Fe[subscript 10]C[subscript 13]: Indications of Fe?Fe Multiple Bonding Emerging from Chemical Frustration

    SciTech Connect

    Hadler, Amelia B.; Fredrickson, Daniel C. (UW)

    2012-10-25

    We report the synthesis and crystal structure of the carbide Gd{sub 13}Fe{sub 10}C{sub 13}. This compound adopts a new structure type that is remarkable for its 'H'-shaped C{sub 2}FeFeC{sub 2} units, which have some of the shortest Fe-Fe contacts known. A bonding analysis using DFT-calibrated Hueckel calculations hints that Fe-Fe multiple bonding underlies these short distances. Gd{sub 13}Fe{sub 10}C{sub 13} undergoes ferromagnetic ordering at {approx}55 K.

  8. Multiple Sclerosis and its Management

    PubMed Central

    Weinshenker, Brian

    1992-01-01

    Multiple sclerosis, the most common disabling disease of the central nervous system affecting young adults, is diagnosed primarily from a history of typical relapsing and remitting white matter symptoms supported by objective signs. Multiple sclerosis may present in more insidious ways or may be mimicked by other diseases, which seemingly satisfy the diagnostic criteria of dissemination in time and space. Patients need psychological support to deal with an uncertain future. A multidisciplinary team approach can best manage both acute temporary disability and, often later, progressive physical and occasionally mental disability. ImagesFigures 1-3 PMID:21221279

  9. SPSS Tutorial for Multiple Comparisons

    NSDL National Science Digital Library

    Little, Laura

    Authored by Laura Little of the University of Washington, this tutorial exposes students to conducting multiple comparisons in SPSS. This html based tutorial provides extensive screen shots and an example data set. Topics covered in the tutorial include: one way ANOVA, preplanned contrasts, Bonferroni, Post Hoc Tukey's HSD, and Scheffe's multiple contrasts. This is a great example of how to use statistical tools such as SPSS in a psychological statistics course. Little does excellent work in providing a step by step approach to learning these methods.

  10. Bilateral Multiple Level Lateral Meningocoele

    PubMed Central

    Kumar, B. E. Panil; Hegde, Kishor V.; Kumari, G. Lalitha; Agrawal, Amit

    2013-01-01

    Lateral meningocoele is a very rare disorder characterized by extensions of the dura and arachnoid through an enlarged neural foramen. We report a case of a 23-year-old female with deformity of spine who presented with low back pain and no neurological deficits. A whole spine magnetic resonance imaging showed multiple well-defined cystic masses involving dorsal, lumbar, and sacral spinal levels bilaterally, with dural ectasia and neural foraminal widening suggestive of bilateral multiple level lateral meningocoele. The patient is being managed conservatively and is on regular follow-up. PMID:23607071

  11. Multiple resonant railgun power supply

    DOEpatents

    Honig, E.M.; Nunnally, W.C.

    1985-06-19

    A multiple repetitive resonant railgun power supply provides energy for repetitively propelling projectiles from a pair of parallel rails. A plurality of serially connected paired parallel rails are powered by similar power supplies. Each supply comprises an energy storage capacitor, a storage inductor to form a resonant circuit with the energy storage capacitor and a magnetic switch to transfer energy between the resonant circuit and the pair of parallel rails for the propelling of projectiles. The multiple serial operation permits relatively small energy components to deliver overall relatively large amounts of energy to the projectiles being propelled.

  12. Multiple scattering in single scatterers

    NASA Astrophysics Data System (ADS)

    Cai, Liang-Wu

    2004-03-01

    Scattering by a multilayered scatterer is analyzed via a novel multiple-scattering approach. Based on the recognition that multiple scattering occurs within single scatterers having internal interfaces, the solution procedure follows the physical process, and yields analytically exact solutions. A simple two-layered scatterer subjected to SH incident waves is used to illustrate the detailed solution procedure. The solution is then verified by a two-layered circular cylindrical scatterer, whose exact analytical solution has previously been obtained by the author [J. Acoust. Soc. Am. (2004)]. The proposed approach opens new ways for analyzing scatterers of more complicated geometrical and physical compositions.

  13. Multiple order common path spectrometer

    NASA Technical Reports Server (NTRS)

    Newbury, Amy B. (Inventor)

    2010-01-01

    The present invention relates to a dispersive spectrometer. The spectrometer allows detection of multiple orders of light on a single focal plane array by splitting the orders spatially using a dichroic assembly. A conventional dispersion mechanism such as a defraction grating disperses the light spectrally. As a result, multiple wavelength orders can be imaged on a single focal plane array of limited spectral extent, doubling (or more) the number of spectral channels as compared to a conventional spectrometer. In addition, this is achieved in a common path device.

  14. Multiple teleportation via the partially entangled states

    E-print Network

    Meiyu Wang; Fengli Yan

    2009-03-08

    We investigate the multiple teleportation with some nonmaximally entangled channels. The efficiencies of two multiple teleportation protocols, the separate multiple teleportation protocol (SMTP) and the global multiple teleportation protocol (GMTP), are calculated. We show that GMTP is more efficient than SMTP.

  15. Fast sparse matrix multiplication Raphael Yuster

    E-print Network

    Yuster, Raphael

    Fast sparse matrix multiplication Raphael Yuster Uri Zwick Abstract Let A and B two n Ã? n.e., multiplications, additions and subtractions) over R. The naive matrix multiplication algorithm, on the other hand faster than the best known matrix multiplication algorithm for dense matrices which uses O(n2

  16. Multiple stars: designation, catalogues, A. Tokovinin1

    E-print Network

    Tokovinin, Andrei A.

    Multiple stars: designation, catalogues, statistics A. Tokovinin1 Cerro Tololo Inter of multiple-star components leads to a conclusion that, apart from components, we need to designate systems in the multiple star catalogue, now available on-line. A short review of multiple-star statistics is given

  17. Modular Multiplication using Redundant Digit Division

    E-print Network

    California at Davis, University of

    Modular Multiplication using Redundant Digit Division Ping Tak Peter Tang Intel Corporation 2200 multiplication, ABR-1 mod N, instead of modular multiplication, AB mod N, even the former re- quires some transformational overheads. This is so because a state-of-the-art Montgomery multiplication implementa- tion has

  18. Dean's Great Discovery: Multiplication, Division and Fractions

    ERIC Educational Resources Information Center

    Vale, Colleen; Davies, Anne

    2007-01-01

    Multiplication, division and fractions are "hotspots" for students in the middle years with many students experiencing difficulty with these concepts. Arrays effectively model multiplication and help children develop multiplicative thinking and learn multiplication facts. In this article the authors show how an open-ended array problem enabled a…

  19. Bivariate Polynomial Multiplication \\Lambda Markus Blaser

    E-print Network

    Bläser, Markus

    Bivariate Polynomial Multiplication \\Lambda Markus BlË?aser Institut fË?ur Informatik II, Universit in [5], we study the mul­ tiplicative complexity and the rank of the multiplication in the local))\\Delta dim Tn for the multiplicative complexity of the multiplication in R m;n and Tn , respectively

  20. On the Time Required to Perform Multiplication

    Microsoft Academic Search

    Shmuel Winograd; Yorktown Heights

    1967-01-01

    The time required to perform multiplication is investigated. A lower bound on the time required to perform multiplication, as well as multiplication modulo N, is derived and it is shown that these lower bounds can be approached. Then a lower bound on the amount of time required to perform the most significant part of multiplication (⌞xy\\/N⌟) is derived.

  1. Typeface and Multiple Choice Option Format.

    ERIC Educational Resources Information Center

    Follman, John; And Others

    The effects of typeface and item options arrangement on comprehension as indicated by multiple-choice test performance were investigated. Copies of the Ability to Interpret Reading Materials in the Social Studies, SRA Iowa Tests of Educational Development, Form X-4 were prepared in four typefaces: elite, pica, proportional, and script. For each…

  2. Genetics Reasoning with Multiple External Representations.

    ERIC Educational Resources Information Center

    Tsui, Chi-Yan; Treagust, David F.

    2003-01-01

    Explores a case study of a class of 10th grade students whose learning of genetics involved activities using BioLogica, a computer program that features multiple external representations (MERs). Findings indicate that the MERs in BioLogica contributed to students' development of genetics reasoning by engendering their motivation and interest but…

  3. Neuropsychology of multiple sclerosis: A critical review

    Microsoft Academic Search

    Stephen M. Rao

    1986-01-01

    Multiple sclerosis (MS) is a relatively common, chronic progressive neurological illness affecting individuals primarily in the third and fourth decades of life. Autopsy studies indicate that the disease preferentially attacks white matter throughout the CNS, including the cerebral hemispheres. This article reviews the current state of knowledge regarding cognitive dysfunction in MS and relates these findings to neuropathological changes. The

  4. PPAR-?: Therapeutic Potential for Multiple Sclerosis

    PubMed Central

    Drew, Paul D.; Xu, Jihong; Racke, Michael K.

    2008-01-01

    The role of peroxisome proliferator-activated receptors (PPARs) in altering lipid and glucose metabolism is well established. More recent studies indicate that PPARs also play critical roles in controlling immune responses. We and others have previously demonstrated that PPAR-? agonists modulate the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This review will discuss the cellular and molecular mechanisms by which these agonists are believed to modulate disease. The therapeutic potential of PPAR-? agonists in the treatment of multiple sclerosis will also be considered. PMID:18604287

  5. Occupational therapy for multiple sclerosis

    Microsoft Academic Search

    E. M. J. Steultjens; J. Dekker; L. M. Bouter; M. Cardol; J. C. M. van de Nes; C. H. M. van den Ende

    2003-01-01

    Background: Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration of upper extremity fine motor coordination, loss of sensation and spasticity that causes limitations in performance of activities of daily living and social participation. The primary purpose of occupational therapy is to enable individuals to participate in self-care, work and leisure activities that

  6. Escalating Immunotherapy of Multiple Sclerosis

    Microsoft Academic Search

    P. Rieckmann; K. V. Toyka

    1999-01-01

    The promising results of several multicenter studies during the last few years have improved the immunomodulatory treatment of multiple sclerosis (MS). The different compounds tested were shown to reduce the number of relapses and to modulate the course of disease to various extents. The transition of the results obtained in therapeutic trials into daily clinical practice is often delayed or

  7. A theory of multiplication noise

    Microsoft Academic Search

    JAMES N. HOLLENHORST

    1990-01-01

    A general theory of noise in avalanche photodiodes (APDs), photomultipliers, and other cascaded multiplication devices in which ionization is independent of a carrier's history is presented. The theory is based on a composition law that allows the calculation of the gain distribution of a multilayer structure from the known distributions for each layer. The composition law is used to establish

  8. Presentation 7: Multiple Primary Rules

    Cancer.gov

    MP Rules - Note 2 The registrar must recognize that during the diagnostic workup the physician may start with a non-specific diagnosis (NOS) and as testing is completed, a more specific histology is identified. These diagnoses are not multiple primaries; they represent steps in the diagnostic work-up. See rules M7-M12.

  9. Fungible Weights in Multiple Regression

    ERIC Educational Resources Information Center

    Waller, Niels G.

    2008-01-01

    Every set of alternate weights (i.e., nonleast squares weights) in a multiple regression analysis with three or more predictors is associated with an infinite class of weights. All members of a given class can be deemed "fungible" because they yield identical "SSE" (sum of squared errors) and R[superscript 2] values. Equations for generating…

  10. MULTIPLE SCLEROSIS AND THE UROLOGIST

    Microsoft Academic Search

    SCOTT E. LITWILLER; ELLIOT M. FROHMAN; PHILIPPE E. ZIMMERN

    1999-01-01

    Purpose: We provide an updated reference detailing the neurological and urological state of the art approach to multiple sclerosis (MS) with special emphasis on the pathology and physiology, effects on the genitourinary tract, diagnostic evaluation, and treatment of neurological and urological manifestations. Materials and Methods: A MEDLINE computerized reference search and manual bibliography review were performed to find pertinent peer

  11. Multiple Literacies Theory: Exploring Futures

    ERIC Educational Resources Information Center

    Masny, Diana

    2011-01-01

    This article focuses on the contributions of philosophy, art and science to education through the conceptual, theoretical, and methodological usefulness of a Deleuze-Guattarian conceptual framework that informs multiple literacies theory (MLT). Education lends itself to Deleuze's notion of connecting and creating through philosophy, art and…

  12. Mechanisms of multiple chemical sensitivity

    Microsoft Academic Search

    Chris Winder

    2002-01-01

    Sensitivity to chemicals is a toxicological concept, contained in the dose–response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a debilitating, multi-organ sensitivity following chemical exposures. Many aspects of this condition extend the nature of sensitivity to

  13. Coping with Multiple Chemical Sensitivity

    Microsoft Academic Search

    Carole A. Larson

    1998-01-01

    Multiple Chemical Sensitivity (MCS) is a disease not well understood by the medical profession or society at large, and the nature of the illness is under debate. In such a fluid environment, the Internet has become a virtual treasure chest of current MCS information, much of which is full text. This article presents selected Internet sites chosen to assist those

  14. Interactive Multiple Objective Programming Methods

    Microsoft Academic Search

    Pekka Korhonen; Jyrki Wallenius

    \\u000a We provide an introduction to interactive methods in multiple objective programming1. Our discussion focuses on the principles to implement such methods. Our purpose is not to review existing procedures, but\\u000a to provide some examples to illustrate the underlying main ideas. Furthermore, we discuss two available software systems developed\\u000a to implement interactive methods.

  15. Multiple Pathways for All Students

    ERIC Educational Resources Information Center

    Stirling, Lee Anna

    2012-01-01

    Maine has been focusing on the importance of postsecondary training. Maine's Skowhegan Area High School (SAHS) and Somerset Career and Technical Center (SCTC) have partnered in a Multiple Pathways initiative (funded by the Nellie Mae Education Foundation) to increase students' high school completion rate and to increase enrollment in postsecondary…

  16. Improving Multiple-Choice Questions

    ERIC Educational Resources Information Center

    Torres, Cristina; Lopes, Ana Paula; Babo, Lurdes; Azevedo, Jose

    2011-01-01

    A MC (multiple-choice) question can be defined as a question in which students are asked to select one alternative from a given set of alternatives in response to a question stem. The objective of this paper is to analyse if MC questions may be considered as an interesting alternative for assessing knowledge, particularly in the mathematics area,…

  17. Improving Inferences from Multiple Methods.

    ERIC Educational Resources Information Center

    Shotland, R. Lance; Mark, Melvin M.

    1987-01-01

    Multiple evaluation methods (MEMs) can cause an inferential challenge, although there are strategies to strengthen inferences. Practical and theoretical issues involved in the use by social scientists of MEMs, three potential problems in drawing inferences from MEMs, and short- and long-term strategies for alleviating these problems are outlined.…

  18. Quantum Multiple Scattering: Correspondence between

    E-print Network

    Heller, Eric

    and Molecular Physics (ITAMP), for many fruitful conversations on atom-photon interactions. I would also likeQuantum Multiple Scattering: Correspondence between Particle and Photon Scattering A thesis presented by Sheng Li to The Department of Chemistry and Chemical Biology in partial ful#12;llment

  19. Enhancing Learning through Multiple Intelligences

    ERIC Educational Resources Information Center

    Ozdemir, Pinar; Guneysu, Sibel; Tekkaya, Ceren

    2006-01-01

    This study investigated whether there was a significant difference between multiple intelligence instruction (MII) and traditionally designed science instruction (TDSI) on fourth grade students' understanding of concepts associated with the "Diversity of Living Things" unit. Students' intelligence types were also examined. There were two…

  20. Object Localization with Multiple Sensors

    Microsoft Academic Search

    Shashank Shekhar; Oussama Khatib; Makoto Shimojo

    1988-01-01

    We present a method to obtain the position and orientation of an object through measurement from multiple sensors. Raw sensor measurements are subject to limitations of sensor precision and accuracy. Although for most measurements the estimate of position parameters is a linear function of the measurements, the estimate of orientation parameters is a nonlinear function of the measurements. Thus, error

  1. Symptomatic Treatment of Multiple Sclerosis

    Microsoft Academic Search

    T. Henze; P. Rieckmann; K. V. Toyka

    2006-01-01

    Besides immunomodulation and immunosuppression, the specific treatment of symptoms is an essential component of the overall management of multiple sclerosis (MS). Symptomatic treatment is aimed at the elimination or reduction of symptoms impairing the functional abilities and quality of life of the affected patients. Moreover, with symptomatic treatment the development of a secondary physical impairment due to an existing one

  2. Multiple Interacting Liquids Frank Losasso

    E-print Network

    Fedkiw, Ron

    ," which is significantly more efficient for multiple regions especially at triple points or near of varying viscosity, 5 phases. (Right) burning oil in water, 4 phases. Abstract The particle level set method has proven successful for the simu- lation of two separate regions (such as water and air, or fuel

  3. Multiple Determinants and Effect Size

    Microsoft Academic Search

    Stephan Ahadi; Edward Diener

    1989-01-01

    Used a Monte Carlo study to investigate the magnitude of various relations among behaviors and traits in the context of a multiple-determinant framework. It was found that when only 3 traits determined each of 2 behaviors and the 2 behaviors were influenced by only 1 common trait, there was an upper bound correlation of about .30 between the 2 behaviors;

  4. Multiple antibiotic resistance and efflux

    Microsoft Academic Search

    Hiroshi Nikaido

    1998-01-01

    Multiple antibiotic resistance in bacteria was at first thought to be caused exclusively by the combination of several resistance genes, each coding for resistance to a single drug. More recently, it became clear that such phenotypes are often achieved by the activity of drug efflux pumps. Some of these efflux pumps exhibit an extremely wide specificity covering practically all antibiotics,

  5. Multiplicative cascade models and multifractality

    E-print Network

    Multiplicative cascade models and multifractality Michael Blank \\Lambda C.N.R.S., Observatoire de construct a (chaotic) deterministic variant of random multiplica­ tive cascade models of turbulence understood. We construct a theory describing deterministic multiplica­ tive cascade models and prove

  6. Matrix multiplication via arithmetic progressions

    Microsoft Academic Search

    Don Coppersmith; Shmuel Winograd

    1987-01-01

    We present a new method for accelerating matrix multiplication asymptotically. This work builds on recent ideas of Volker Strassen, by using a basic trilinear form which is not a matrix product. We make novel use of the Salem-Spencer Theorem, which gives a fairly dense set of integers with no three-term arithmetic progression. Our resulting matrix exponent is 2.376.

  7. Cerebral palsy and multiple births

    Microsoft Academic Search

    P O Pharoah; T Cooke

    1996-01-01

    AIM: To compare the birthweight specific prevalence of cerebral palsy in singleton and multiple births. METHODS: Registered births of babies with cerebral palsy born to mothers resident in the counties of Merseyside and Cheshire during the period 1982 to 1989 were ascertained. RESULTS: The crude prevalence of cerebral palsy was 2.3 per 1000 infant survivors in singletons, 12.6 in twins,

  8. Multiple Intelligences Theory in Action.

    ERIC Educational Resources Information Center

    Lockwood, Anne Turnbaugh

    1993-01-01

    The two articles in this newsletter issue focus on and discuss the multiple intelligences (MI) theory and its application in schools. Developed by Howard Gardner at Harvard University, the theory argues that individuals differ in their abilities, learning styles, and interests, and that these differences need to be acknowledged and nurtured in…

  9. Empowering Students through Multiple Intelligences.

    ERIC Educational Resources Information Center

    Rubado, Karen

    2002-01-01

    Howard Gardner's theory of multiple intelligences challenges narrow concepts of student talent and ability. This article applies this theory to the challenge of educating students with learning behavior disabilities. Reaching these young people and engaging them in learning can help them understand that intelligence comes in many forms. (Author)

  10. Multiple Intelligences: Enabling Diverse Learning.

    ERIC Educational Resources Information Center

    Berger, Eugenia Hepworth; Pollman, Mary Jo

    1996-01-01

    Compares the whole-child approach to early childhood education and Howard Gardner's concept of multiple intelligences. Provides activities and ideas to address each of the seven intelligences, and lists specific suggestions for parent/child experiences, field trip experiences, and constructivist experiences. Stresses individual child potential.…

  11. Childhood Multiple Sclerosis: A Review

    ERIC Educational Resources Information Center

    Waldman, Amy; O'Connor, Erin; Tennekoon, Gihan

    2006-01-01

    Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS) that is increasingly recognized as a disease that affects children. Similar to adult-onset MS, children present with visual and sensory complaints, as well as weakness, spasticity, and ataxia. A lumbar puncture can be helpful in diagnosing MS when…

  12. Corticial lesions in multiple sclerosis

    Microsoft Academic Search

    D. Kidd; F. Barkhof; R. McConnell; P. R. Algra; I. V. Allen; T. Revesz

    1999-01-01

    Summary Although previous studies have shown that the lesions of multiple sclerosis may involve the cerebral cortex, there is little published research on the prevalence and distribution of such lesions. Using neuropathological techniques and MRI, a series of studies has been undertaken in order to assess this, in particular to identify their relationship to cortical veins. A serial MRI study

  13. Multiple layer CD control treatment

    NASA Astrophysics Data System (ADS)

    Birnstein, Anka; Röpke, Christoph; Sczyrba, Martin; Pforr, Rainer; Hennig, Mario; Ben-Zvi, Guy; Graitzer, Erez; Cohen, Avi

    2009-03-01

    Tight control of intra-field CD variations becomes more and more important as the pattern sizes on wafer shrink. For intra-field CD uniformity improvement several techniques have been developed. A very effective method is changing the local mask blank transmittance according to measured Intra Field (IF) CD variations using Pixer's CDCTM technique. This process is irreversible. For various practical reasons it would be helpful to have the opportunity for a second or more mask blank treatments. A first application could be to improve an unsatisfying CDU post first treatment. A second application can be the switch of the mask usage to another tool group. Furthermore, the opportunity to use multiple CDC treatments would allow the splitting of the correction process for the mask and the tool separately, whereas in a first correction only the mask CDU errors will be corrected and after the mask is supplied to the customer another correction may be required to reduce the exposure tool contributions to the CDU budget. Therefore the intention of the paper is to evaluate the opportunities of a Multiple CDC (MCDC) correction process, to determine its accuracy and the corresponding limits. To do this two CDC tool projection lenses have been characterized, which have been developed for different focus positions. We will characterize their transmittance transfer performance, stability and sensitivities. The required multiple layer distances will be determined. The linearity of the multiple CDC treatment will be analyzed using AIMSTM measurements and wafer prints. We will present results of successful multiple CDC corrections for production masks.

  14. Iron chelation and multiple sclerosis

    PubMed Central

    Weigel, Kelsey J.; Lynch, Sharon G.; LeVine, Steven M.

    2014-01-01

    Histochemical and MRI studies have demonstrated that MS (multiple sclerosis) patients have abnormal deposition of iron in both gray and white matter structures. Data is emerging indicating that this iron could partake in pathogenesis by various mechanisms, e.g., promoting the production of reactive oxygen species and enhancing the production of proinflammatory cytokines. Iron chelation therapy could be a viable strategy to block iron-related pathological events or it can confer cellular protection by stabilizing hypoxia inducible factor 1?, a transcription factor that normally responds to hypoxic conditions. Iron chelation has been shown to protect against disease progression and/or limit iron accumulation in some neurological disorders or their experimental models. Data from studies that administered a chelator to animals with experimental autoimmune encephalomyelitis, a model of MS, support the rationale for examining this treatment approach in MS. Preliminary clinical studies have been performed in MS patients using deferoxamine. Although some side effects were observed, the large majority of patients were able to tolerate the arduous administration regimen, i.e., 6–8 h of subcutaneous infusion, and all side effects resolved upon discontinuation of treatment. Importantly, these preliminary studies did not identify a disqualifying event for this experimental approach. More recently developed chelators, deferasirox and deferiprone, are more desirable for possible use in MS given their oral administration, and importantly, deferiprone can cross the blood–brain barrier. However, experiences from other conditions indicate that the potential for adverse events during chelation therapy necessitates close patient monitoring and a carefully considered administration regimen. PMID:24397846

  15. Coherent optical communication using polarization multiple-input-multiple-output.

    PubMed

    Han, Yan; Li, Guifang

    2005-09-19

    Polarization-division multiplexed (PDM) optical signals can potentially be demultiplexed by coherent detection and digital signal processing without using optical dynamic polarization control at the receiver. In this paper, we show that optical communications using PDM is analogous to wireless communications using multiple-input-multiple-output (MIMO) antennae and thus algorithms for channel estimation in wireless MIMO can be ready applied to optical polarization MIMO (PMIMO). Combined with frequency offset and phase estimation algorithms, simulations show that PDM quadrature phase-shift keying signals can be coherently detected by the proposed scheme using commercial semiconductor lasers while no optical phase locking and polarization control are required. This analogy further suggests the potential application of space-time coding in wireless communications to optical polarization MIMO systems and relates the problem of polarization-mode dispersion in fiber transmission to the multi-path propagation in wireless communications. PMID:19498778

  16. Coherent optical communication using polarization multiple-input-multiple-output

    NASA Astrophysics Data System (ADS)

    Han, Yan; Li, Guifang

    2005-09-01

    Polarization-division multiplexed (PDM) optical signals can potentially be demultiplexed by coherent detection and digital signal processing without using optical dynamic polarization control at the receiver. In this paper, we show that optical communications using PDM is analogous to wireless communications using multiple-input-multiple-output (MIMO) antennae and thus algorithms for channel estimation in wireless MIMO can be ready applied to optical polarization MIMO (PMIMO). Combined with frequency offset and phase estimation algorithms, simulations show that PDM quadrature phase-shift keying signals can be coherently detected by the proposed scheme using commercial semiconductor lasers while no optical phase locking and polarization control are required. This analogy further suggests the potential application of space-time coding in wireless communications to optical polarization MIMO systems and relates the problem of polarization-mode dispersion in fiber transmission to the multi-path propagation in wireless communications.

  17. Integrating individual-based indices of contaminant effects. How multiple sublethal effects may ultimately reduce amphibian recruitment from a contaminated breeding site.

    PubMed

    Rowe, C L; Hopkins, W A; Congdon, J D

    2001-11-29

    Habitat contamination can alter numerous biological processes in individual organisms. Examining multiple individual-level responses in an integrative fashion is necessary to understand how individual health or fitness reflects environmental contamination. Here we provide an example of such an integrated perspective based upon recent studies of an amphibian (the bullfrog, Rana catesbeiana ) that experiences several, disparate changes when larval development occurs in a trace element-contaminated habitat. First, we present an overview of studies focused on specific responses of individuals collected from, or transplanted into, a habitat contaminated by coal combustion residues (CCR). These studies have reported morphological, behavioral, and physiological modifications to individuals chronically interacting with sediments in the CCR-contaminated site. Morphological abnormalities in the oral and tail regions in contaminant-exposed individuals influenced other properties such as grazing, growth, and swimming performance. Behavioral changes in swimming activities and responses to stimuli appear to influence predation risk in the contaminant-exposed population. Significant changes in bioenergetics in the contaminated habitat, evident as abnormally high energetic expenditures for survival (maintenance) costs, may ultimately influence production pathways (growth, energy storage) in individuals. We then present a conceptual model to examine how interactions among the affected systems (morphological, behavioral, physiological) may ultimately bring about more severe effects than would be predicted if the responses were considered in isolation. A complex interplay among simultaneously occurring biological changes emerges in which multiple, sublethal effects ultimately can translate into reductions in larval or juvenile survival, and thus reduced recruitment of juveniles into the population. In systems where individuals are exposed to low concentrations of contaminants for long periods of time, research focused on one or few sublethal responses could substantially underestimate overall effects on individuals. We suggest that investigators adopt a more integrated perspective on contaminant-induced biological changes so that studies of individual-based effects can be better integrated into analyses of mechanisms of population change. PMID:12805772

  18. A Scalable Architecture for Modular Multiplication Based on

    E-print Network

    A Scalable Architecture for Modular Multiplication Based on Montgomery's Algorithm Alexandre F architecture for the computation of modular multiplication, based on the Montgomery multiplication (MM or bandwidth requirement. Index Terms--Cryptography, Montgomery multiplication, modular multiplication, modular

  19. Intrascrotal and Extratesticular Multiple Schwannoma

    PubMed Central

    Kim, Young-Joo; Kim, Sung Dae

    2013-01-01

    Schwannoma, which may occur in any region of the body, is very rare in the scrotum. Schwannomas are tumors that originate from Schwann cells and, theoretically, could affect any nerve. In spite of the rich innervation of the genital area, these kinds of tumors are not common in the scrotum. A 67-year-old man visited our hospital for investigation of a 2-year episode of multiple slowly growing masses in the scrotum. Testicular tumor markers were within normal range (beta human chorionic gonadotropin <5 mIU, ?-fetoprotein : 4.86 ng/ml). Scrotal ultrasonography revealed intrascrotal and extratesticular masses in the mid-scrotal region. Complete excision of the scrotal masses was performed. After surgery there was no testicular invasion. Histological examination of the resected specimen showed them to be schwannomas of the scrotum. We report one case of multiple schwannomas of the scrotum with a review of the literature. PMID:24044115

  20. Method for deploying multiple spacecraft

    NASA Technical Reports Server (NTRS)

    Sharer, Peter J. (Inventor)

    2007-01-01

    A method for deploying multiple spacecraft is disclosed. The method can be used in a situation where a first celestial body is being orbited by a second celestial body. The spacecraft are loaded onto a single spaceship that contains the multiple spacecraft and the spacecraft is launched from the second celestial body towards a third celestial body. The spacecraft are separated from each other while in route to the third celestial body. Each of the spacecraft is then subjected to the gravitational field of the third celestial body and each of the spacecraft assumes a different, independent orbit about the first celestial body. In those situations where the spacecraft are launched from Earth, the Sun can act as the first celestial body, the Earth can act as the second celestial body and the Moon can act as the third celestial body.

  1. Multiple Single-Centered Attractors

    E-print Network

    Pramod Dominic; Taniya Mandal; Prasanta K. Tripathy

    2015-04-23

    In this paper we study spherically symmetric single-centered attractors in N=2 supergravity in four dimensions. The attractor points are obtained by extremising the effective black hole potential in the moduli space. Using the 4D-5D correspondence of critical points of the effective black hole potential we argue the existence of multiple attractors in four dimensions and explicitly construct a pair of multiple solutions in a simple two parameter model. We further obtain explicit examples of two distinct non-supersymmetric attractors in type IIA string theory compactified on K3 X T2 carrying D0-D4-D6 charges. We compute the entropy of these attractors and analyse their stability in detail.

  2. Clinical trials in multiple sclerosis.

    PubMed

    Cutter, Gary; Kappos, Ludwig

    2014-01-01

    This chapter discusses topics in the design of clinical trials for Multiple Sclerosis. This nontechnical discussion introduces concepts such as phases of trials, basic design strategies and the importance of the question at hand and the outcomes. The chapter discusses the concept of Bayesian statistical design versus Frequentist approaches. A host of modern designs ranging from adaptive designs to treatment paradigms to targeted designs are introduced. Strategies for treatment selection, randomized withdrawal designs and futility designs are covered. Finally how to evaluate multiple drugs in an era of limited placebo controlled trials are discussed and the chapter ends with the competing demands of the shortest trials to get efficacy answers for immediate goals versus the value of long term studies for future outcomes and long term safety. PMID:24507530

  3. Multiple idiopathic apical root resorption.

    PubMed

    Kanungo, Manish; Khandelwal, Vishal; Nayak, Ullal Anand; Nayak, Prathibha Anand

    2013-01-01

    Idiopathic external root resorption is a rarely reported condition which has been observed in single or multiple teeth. This is a rare case of multiple idiopathic apical root resorption (MIARR) in a 16-year-old boy. External root resorption of the permanent teeth is a multifactorial process. Well-recognised causes of apical root resorption in permanent teeth include orthodontic therapy, trauma, periapical or periodontal inflammation, tumours, cysts, occlusal stresses, impacted teeth, systemic conditions, endocrine imbalances and dietary habits. When none of these causes are present, it is termed idiopathic root resorption which may be either cervical or apical. MIARR is a rare condition which is usually detected as an incidental radiographic finding. However, it may cause pain and mobility in severe cases. PMID:23616336

  4. Harmonic multiplication using resonant tunneling

    NASA Technical Reports Server (NTRS)

    Sollner, T. C. L. G.; Brown, E. R.; Goodhue, W. D.; Correa, C. A.

    1988-01-01

    This paper demonstrates the use of resonant-tunneling diodes as varistors for harmonic multiplication. It is shown that efficient odd-harmonic conversion is possible and that even harmonics do not appear because of the antisymmetry of the current-voltage (I-V) curve. It is also shown that, with the proper choice of resonant-tunneling structure and pump amplitude, most of the harmonic output power can be confined to a single odd-harmonic frequency. Fifth-harmonic multiplication was demonstrated with an output at 21.75 GHz and a power conversion efficiency of 0.5 percent, and a fifth-harmonic efficiency of 2.7 percent was achieved in a circuit simulation using an improved I-V curve.

  5. Multiple target laser ablation system

    DOEpatents

    Mashburn, Douglas N. (Knoxville, TN)

    1996-01-01

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

  6. Multiple target laser ablation system

    DOEpatents

    Mashburn, D.N.

    1996-01-09

    A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

  7. The paradox of multiple elections

    Microsoft Academic Search

    Steven J. Brams; D. Marc Kilgour; William S. Zwicker

    1998-01-01

    .   Assume that voters must choose between voting yes (Y) and voting no (N) on three propositions on a referendum. If the winning\\u000a combination is NYY on the first, second, and third propositions, respectively, the paradox of multiple elections is that NYY can receive the fewest votes of the 23?=?8 combinations. Several variants of this paradox are illustrated, and necessary

  8. [Special cases of multiple sclerosis].

    PubMed

    Mendibe Bilbao, Mar

    2014-12-01

    Multiple sclerosis is a chronic disease that usually occurs in young people and affects them for the rest of their lives. Patients and their families usually have a series of doubts and questions on everyday matters and all types of situations that occur during the distinct stages of life and which can influence the course of the disease. The aim of this review is to provide specific answers to these questions. PMID:25732948

  9. Intensive therapy in multiple myeloma

    Microsoft Academic Search

    C. M. Segeren

    2002-01-01

    Multiple myeloma is still an iocurable disease. With combioation chemotherapy the\\u000amedian survival is about 3 years. High-dose therapy with autologous or allogeneic stem\\u000acell support has been used in an attempt to improve response rate and survival. Promising\\u000aresults of this approach have led to even further dose iotensification with double highdose\\u000atherapy end stem eel! support. Randomized studies

  10. Multiple sclerosis and birth order.

    PubMed Central

    James, W H

    1984-01-01

    Studies on the birth order of patients with multiple sclerosis have yielded contradictory conclusions. Most of the sets of data, however, have been tested by biased tests. Data that have been submitted to unbiased tests seem to suggest that cases are more likely to occur in early birth ranks. This should be tested on further samples and some comments are offered on how this should be done. PMID:6707558

  11. Multiple Vaccinations: Friend or Foe

    PubMed Central

    Church, Sarah E.; Jensen, Shawn M.; Twitty, Chris; Bahjat, Keith; Hu, Hong-Ming; Urba, Walter J.; Fox, Bernard A.

    2013-01-01

    Few immunotherapists would accept the concept of a single vaccination inducing a therapeutic anti-cancer immune response in a patient with advanced cancer. But what is the evidence to support the “more-is-better” approach of multiple vaccinations? Since we are unaware of trials comparing the effect of a single vaccine versus multiple vaccinations on patient outcome, we considered that an anti-cancer immune response might provide a surrogate measure of the effectiveness of vaccination strategies. Since few large trials include immunological monitoring, the majority of information is gleaned from smaller trials in which an evaluation of immune responses to vaccine or tumor, before and at one or more times following the first vaccine was performed. In some studies there is convincing evidence that repeated administration of a specific vaccine can augment the immune response to antigens contained in the vaccine. In other settings multiple vaccinations can significantly reduce the immune response to one or more targets. Results from three large adjuvant vaccine studies support the potential detrimental effect of multiple vaccinations as clinical outcomes in the control arms were significantly better than that for treatment groups. Recent research has provided insights into mechanisms that are likely responsible for the reduced responses in the studies noted above, but supporting evidence from clinical specimens is generally lacking. Interpretation of these results is further complicated by the possibility that the dominant immune response may evolve to recognize epitopes not present in the vaccine. Nonetheless, the FDA-approval of the first therapeutic cancer vaccine and recent developments from preclinical models and clinical trials provide a substantial basis for optimism and a critical evaluation of cancer vaccine strategies. PMID:21952289

  12. Multiple-Access Bosonic Communications

    E-print Network

    Brent J. Yen; Jeffrey H. Shapiro

    2005-10-18

    The maximum rates for reliably transmitting classical information over Bosonic multiple-access channels (MACs) are derived when the transmitters are restricted to coherent-state encodings. Inner and outer bounds for the ultimate capacity region of the Bosonic MAC are also presented. It is shown that the sum-rate upper bound is achievable with a coherent-state encoding and that the entire region is asymptotically achievable in the limit of large mean input photon numbers.

  13. The Complexity of Iterated Multiplication

    E-print Network

    Massachusetts at Amherst, University of

    Supported by NSF grants DMS-8807202 and CCR-8802835. 1 #12;FO = AC0 ThC0 NC1 L NL AC1 DET* ThC1 NC2 DSPACE log2 n surprising fact { reported in BCH, Rei] { is that iterated integer multiplication is in P-uniform ThC0 but not known to be in (uniform) ThC0 , or even in L. Usually, uniformity does not pose as a serious issue

  14. Neurogenic bladder from multiple sclerosis

    Microsoft Academic Search

    Brian L. Cohen; Line Leboeuf; Angelo E. Gousse

    2008-01-01

    Multiple sclerosis (MS) is an autoimmune disorder affecting the central nervous system. Because MS is a chronic disease that\\u000a can affect any part of the central nervous system, most patients experience voiding dysfunction during the course of the disease.\\u000a Depending on the site of plaques within the central nervous system, various complaints may arise. Familiarity is required\\u000a with the evaluation

  15. Matrix Multiplication via Arithmetic Progressions

    Microsoft Academic Search

    Don Coppersmith; Shmuel Winograd

    1990-01-01

    We present a new method for accelerating matrix multiplication asymptotically. This work builds on recent ideas of Volker Strassen,by using a basic trilinear form which is not a matrix product. We make novel use of the Salem-Spencer Theorem, which gives a fairly dense set of integers with no three-term arithmetic progression. Our resulting matrix exponent is 2.376.

  16. Gene therapy of multiple sclerosis

    Microsoft Academic Search

    Roberto Furlan; Chiara Maiorino; Alberto Gatta; Francesca Ruffini; Gianvito Martino

    \\u000a Multiple sclerosis (MS) constitutes a difficult challenge for the design of innovative therapies: the aetiology is unknown,\\u000a the pathogenesis only partially understood, and the whole process is multi-focal, chronic, and occurring beyond anatomical\\u000a barriers, making the delivery of potentially therapeutic molecules difficult. Gene therapy, thus, constitutes a realistic\\u000a alternative to ensure prolonged, and site-specific delivery of therapies. Recent advancements in

  17. Interferon Beta in Multiple Sclerosis

    Microsoft Academic Search

    Barry G. W. Arnason

    1996-01-01

    Interferon beta 1B (IFN?1b) lessens multiple sclerosis (MS) attack frequency and accumulating disease burden as assessed by MRI. The agent is an immune system modulator. The immune response in MS is thought to involve a delayed-type hypersensitivity (DTH) response mediated by Th1 type T cells. IFN?1blessens expression of MHC-class II proteins on blood monocytes but only after a delay. This

  18. Inverse Relationships (Multiplication and Division)

    NSDL National Science Digital Library

    2012-07-13

    This activity for the interactive white board (free access with registration) provides an opportunity for learners to practice building the fact family sets to reinforce the inverse relationship between multiplication and division. A set of three numbers are displayed and the learner drags the numbers and the operation down into the spaces to create a number fact (equation). The goal is to find all four facts in the family.

  19. [Intensive treatment of multiple myeloma].

    PubMed

    Harousseau, Jean-Luc

    2003-01-01

    High dose therapy with autologous stem cell transplantation (ASCT) has been extensively used in the past 15 years in multiple myeloma. The IFM 90 trial has shown that autologous bone marrow transplantation (BMT) is superior to conventional chemotherapy in terms of response rate, event free survival, overall survival. Several other randomized studies confirm that ASCT yields superior complete remission and event free survival rates. However, the benefit for overall survival is not always significant because some patients may receive high dose therapy at the time of relapse. While ASCT appears to be the treatment of choice for younger patients, a number of questions have been addressed in the past few years (optimal conditioning regimen, best source of stem cells, impact of tandem autotransplants, role of maintenance therapy, results of transplantation in patients over 65 years of age or with renal failure). These issues are addressed in this review. Analysis of large cohorts of patients indicate that a low beta 2 microglobulin level and the absence of chromosome 13 abnormalities are associated with a better outcome. However in patients with a high beta 2 microglobulin level and chromosome 13 abnormalities, the prognosis is poor even after tandem transplantations. Allogeneic BMT is offered to a minority of younger patients with an HLA identical sibling. Initial series have shown a high-toxic death rate and no survival advantage compared to ASCT. Yet, allogeneic BMT is possibly the only curative therapy. Reports of CR achieved after infusion of donor lymphoid cells in patients relapsing after allogeneic BMT support the concept of a graft versus myeloma effect. Therefore, the objectives of current studies are to reduce transplant related mortality by using earlier BMT, better selection of patients, better graft-versus host prophylaxis or non myeloablative conditioning regimens. PMID:14556449

  20. pADIC MULTIPLE ZETA VALUES I ---pADIC MULTIPLE POLYLOGARITHMS AND THE

    E-print Network

    p­ADIC MULTIPLE ZETA VALUES I --- p­ADIC MULTIPLE POLYLOGARITHMS AND THE p­ADIC KZ EQUATION­adic multiple zeta values. We introduce (one variable) p­adic multiple polylogarithms by Coleman's p­adic iter­ ated integration theory. We define p­adic multiple zeta values to be special values of p­adic multiple

  1. Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop.

    PubMed Central

    van Zaanen, H C; Koopmans, R P; Aarden, L A; Rensink, H J; Stouthard, J M; Warnaar, S O; Lokhorst, H M; van Oers, M H

    1996-01-01

    In vitro as well as in vivo observations have shown that IL6 plays a key role in the pathogenesis of multiple myeloma. Therefore we started a phase I/II dose escalating study with chimeric monoclonal anti-IL6 antibodies (cMab) in multiple myeloma (MM) patients resistant to second-line chemotherapy. Here we describe the pharmacological data as well as a new method for calculating the endogenous IL6 production. The cMab (CLB IL6/8; Kd: 6.25 x 10(-12) M) was given in two cycles of 14 daily infusions, starting on day 1 and day 28. Daily dose: 5 mg in patients 1-3, 10 mg in patients 4-6, and 20 mg in patients 7-9 (total dose 140, 280, and 560 mg of anti-IL6, respectively). Using the pharmacokinetic data of free IL6 and the binding characteristics of the cMab, the endogenous IL6 production could be calculated from day to day using a one-compartment open model. The median half-life time of this antibody was 17.6 d. No human antichimeric antibodies were induced. Pre-treatment median endogenous IL6 production in the MM patients was 60 micrograms/d (range 13.8-230; normal controls < 7 micrograms/d). During treatment with anti-IL6 cMabs, the endogenous IL6 production immediately decreased in all patients to below 3 micrograms/d and never reached the pre-treatment value during the treatment period, except in two patients who developed an active infection, resulting in an IL6 production of 128 and 1,208 micrograms/d, respectively. We concluded that in MM patients endogenous IL6 production is 2-30 times higher than in healthy individuals. The anti-IL6 cMab strongly suppress this endogenous IL6 production, probably by blocking a positive feed-back loop, but this cMab does not prevent infection-induced IL6 production. The chimeric anti-IL6 Mabs have a long half-life time, a low immunogenicity, and are able to block IL6-dependent processes in vivo. PMID:8823310

  2. Modeling Multiple Causes of Carcinogenesis

    SciTech Connect

    Jones, T.D.

    1999-01-24

    An array of epidemiological results and databases on test animal indicate that risk of cancer and atherosclerosis can be up- or down-regulated by diet through a range of 200%. Other factors contribute incrementally and include the natural terrestrial environment and various human activities that jointly produce complex exposures to endotoxin-producing microorganisms, ionizing radiations, and chemicals. Ordinary personal habits and simple physical irritants have been demonstrated to affect the immune response and risk of disease. There tends to be poor statistical correlation of long-term risk with single agent exposures incurred throughout working careers. However, Agency recommendations for control of hazardous exposures to humans has been substance-specific instead of contextually realistic even though there is consistent evidence for common mechanisms of toxicological and carcinogenic action. That behavior seems to be best explained by molecular stresses from cellular oxygen metabolism and phagocytosis of antigenic invasion as well as breakdown of normal metabolic compounds associated with homeostatic- and injury-related renewal of cells. There is continually mounting evidence that marrow stroma, comprised largely of monocyte-macrophages and fibroblasts, is important to phagocytic and cytokinetic response, but the complex action of the immune process is difficult to infer from first-principle logic or biomarkers of toxic injury. The many diverse database studies all seem to implicate two important processes, i.e., the univalent reduction of molecular oxygen and breakdown of aginuine, an amino acid, by hydrolysis or digestion of protein which is attendant to normal antigen-antibody action. This behavior indicates that protection guidelines and risk coefficients should be context dependent to include reference considerations of the composite action of parameters that mediate oxygen metabolism. A logic of this type permits the realistic common-scale modeling of multiple causes of carcinogenesis and shifts the risk-assessment logic to considerations of ?what dose does?? in contrast to the current process of the substance-specific question of ?what dose is?? Whether reactive oxygen is the proximate or contributing cause of disease or simply a better estimate of biologically effective dose, it has enormous advantages for improved risk- and policy-based decisions. Various estimates of immune system modulation will be given based on radiobiology.

  3. Multiple frequency printed slot and dipole antennas 

    E-print Network

    Kolsrud, Arild

    1997-01-01

    Multiple frequency antennas are becoming more and more important as the technology advances. Printed circuit antennas can be designed to achieve multiple frequency operation. The advantages like low cost, conformal and planar, and a possible...

  4. Aortic Aneurysm - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Aortic Aneurysm URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Aortic Aneurysm - Multiple Languages To use the sharing features on ...

  5. Multiple Instance Regression with Structured Data

    NASA Technical Reports Server (NTRS)

    Wagstaff, Kiri L.; Lane, Terran; Roper, Alex

    2008-01-01

    This slide presentation reviews the use of multiple instance regression with structured data from multiple and related data sets. It applies the concept to a practical problem, that of estimating crop yield using remote sensed country wide weekly observations.

  6. Circuit provides accurate four-quadrant multiplication

    NASA Technical Reports Server (NTRS)

    Mc Gowan, G. F.

    1966-01-01

    Solid state circuit provides four-quadrant multiplication at frequencies ranging from dc to 100 cps using pulse-width and -height multiplication techniques. The circuit consumes little power and has an accuracy of approximately one percent.

  7. Fuzzy Multiple Heuristic Orderings for Examination Timetabling

    E-print Network

    Aickelin, Uwe

    Fuzzy Multiple Heuristic Orderings for Examination Timetabling Hishammuddin Asmuni1 , Edmund K Heidelberg 2005 #12;Fuzzy Multiple Heuristic Orderings for Examination Timetabling 335 Over the years], hyper- heuristics [13] and various metaheuristic approaches including greedy local search [19], [23

  8. Tooth Disorders - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Tooth Disorders URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Tooth Disorders - Multiple Languages To use the sharing features on ...

  9. Coronavirus Infections - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Coronavirus Infections URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Coronavirus Infections - Multiple Languages To use the sharing features on ...

  10. Manifold Integration: Data Integration on Multiple Manifolds 

    E-print Network

    Choi, Hee Youl

    2011-08-08

    manifold based on one dissimilarity matrix. In practice, multiple measurements may be available, and could be utilized. In pattern recognition systems, data integration has been an important consideration for improved accuracy given multiple measurements...

  11. Rheumatoid Arthritis - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Rheumatoid Arthritis URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Rheumatoid Arthritis - Multiple Languages To use the sharing features on ...

  12. Herbal Medicine - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Herbal Medicine URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Herbal Medicine - Multiple Languages To use the sharing features on ...

  13. Head Lice - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Head Lice URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Head Lice - Multiple Languages To use the sharing features on ...

  14. Oil Spills - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Oil Spills URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Oil Spills - Multiple Languages To use the sharing features on ...

  15. Kidney Cancer - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Kidney Cancer URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Kidney Cancer - Multiple Languages To use the sharing features on ...

  16. The Continuous Coagulation Equation with Multiple Fragmentation

    E-print Network

    Magdeburg, Universität

    The Continuous Coagulation Equation with Multiple Fragmentation Ankik Kumar Giri , Jitendra Kumar of solutions to the continuous coagulation equation with multiple fragmentation whenever the kernels satisfy approximating equations. The question of uniqueness is also considered. Keywords: Particles; Coagulation

  17. All About Multiplication Exploring Equal Sets

    NSDL National Science Digital Library

    Illuminations National Council of Teachers of Math

    2009-03-17

    Students explore the set model for multiplication. They find products using equal sets and present their results in a table. Next students apply their knowledge about multiplication in the creation of pictographs (from NCTM's Illuminations website).

  18. Teaching Multiplication Algorithms from Other Cultures

    ERIC Educational Resources Information Center

    Lin, Cheng-Yao

    2007-01-01

    This article describes a number of multiplication algorithms from different cultures around the world: Hindu, Egyptian, Russian, Japanese, and Chinese. Students can learn these algorithms and better understand the operation and properties of multiplication.

  19. Dietary Fats - Multiple Languages: MedlinePlus

    MedlinePLUS

    ... Are Here: Home ? Multiple Languages ? All Health Topics ? Dietary Fats URL of this page: http://www.nlm.nih. ... V W XYZ List of All Topics All Dietary Fats - Multiple Languages To use the sharing features on ...

  20. Assessing Student Learning through Multiple Intelligences.

    ERIC Educational Resources Information Center

    McClaskey, Janet

    1995-01-01

    Gives practical examples of multiple intelligences in the English classroom. Discusses Howard Gardner's "radicalism,""teaching" intelligence, teaching literature and multiple intelligences, and how a student developed strength in his own intelligences through poetry. (RS)

  1. C* -pseudo-multiplicative unitaries Thomas Timmermann

    E-print Network

    Timmermann, Thomas

    C* -pseudo-multiplicative unitaries Thomas"unster September 17, 2007 Abstract We introduce C*-pseudo-multiplicative unitaries and (concrete) Hopf C*-* *bimodules, which are C*-algebraic variants of the pseudo

  2. Generic Copaxone Approved for Multiple Sclerosis

    MedlinePLUS

    ... news/fullstory_152066.html Generic Copaxone Approved for Multiple Sclerosis Autoimmune disease affects central nervous system To use ... by the Food and Drug Administration to treat multiple sclerosis (MS). The brand-name drug is produced by ...

  3. 42 CFR 102.45 - Multiple survivors.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request Packages...45 Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...

  4. 42 CFR 102.45 - Multiple survivors.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request Packages...45 Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...

  5. 42 CFR 102.45 - Multiple survivors.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request Packages...45 Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...

  6. Multiple memory systems as substrates for multiple decision systems.

    PubMed

    Doll, Bradley B; Shohamy, Daphna; Daw, Nathaniel D

    2015-01-01

    It has recently become widely appreciated that value-based decision making is supported by multiple computational strategies. In particular, animal and human behavior in learning tasks appears to include habitual responses described by prominent model-free reinforcement learning (RL) theories, but also more deliberative or goal-directed actions that can be characterized by a different class of theories, model-based RL. The latter theories evaluate actions by using a representation of the contingencies of the task (as with a learned map of a spatial maze), called an "internal model." Given the evidence of behavioral and neural dissociations between these approaches, they are often characterized as dissociable learning systems, though they likely interact and share common mechanisms. In many respects, this division parallels a longstanding dissociation in cognitive neuroscience between multiple memory systems, describing, at the broadest level, separate systems for declarative and procedural learning. Procedural learning has notable parallels with model-free RL: both involve learning of habits and both are known to depend on parts of the striatum. Declarative memory, by contrast, supports memory for single events or episodes and depends on the hippocampus. The hippocampus is thought to support declarative memory by encoding temporal and spatial relations among stimuli and thus is often referred to as a relational memory system. Such relational encoding is likely to play an important role in learning an internal model, the representation that is central to model-based RL. Thus, insofar as the memory systems represent more general-purpose cognitive mechanisms that might subserve performance on many sorts of tasks including decision making, these parallels raise the question whether the multiple decision systems are served by multiple memory systems, such that one dissociation is grounded in the other. Here we investigated the relationship between model-based RL and relational memory by comparing individual differences across behavioral tasks designed to measure either capacity. Human subjects performed two tasks, a learning and generalization task (acquired equivalence) which involves relational encoding and depends on the hippocampus; and a sequential RL task that could be solved by either a model-based or model-free strategy. We assessed the correlation between subjects' use of flexible, relational memory, as measured by generalization in the acquired equivalence task, and their differential reliance on either RL strategy in the decision task. We observed a significant positive relationship between generalization and model-based, but not model-free, choice strategies. These results are consistent with the hypothesis that model-based RL, like acquired equivalence, relies on a more general-purpose relational memory system. PMID:24846190

  7. Multiple Dispatch in Practice Radu Muschevici

    E-print Network

    Potanin, Alex

    Multiple Dispatch in Practice Radu Muschevici Alex Potanin Victoria University of Wellington, New@cs.auckland.ac.nz James Noble Victoria University of Wellington, New Zealand kjx@mcs.vuw.ac.nz Abstract Multiple dispatch to run. While several languages over the last 20 years have provided multiple dispatch, most object

  8. Multiplication Basis of Emergence of Classifiers

    Microsoft Academic Search

    Ben Wai; Hoo Au

    2007-01-01

    This paper aims to develop a multiplication-based inquiry into the emergence of classifiers by answering three questions. What is the role of the nominal suffix (Kayne 2005) in the multiplicative representation of the whole number? How is the nominal suffix linked to the emergence of classifiers? How do classifiers emerge as parcelers and dividers via multiplication (Landman 2004, Borer 2005)?

  9. Disintegrating Multiple Systems in Early Stellar Evolution

    Microsoft Academic Search

    Bo Reipurth

    2000-01-01

    An analysis of the multiplicity of 14 sources driving giant Herbig-Haro flows has revealed an observed binary frequency between 79% and 86%, of which half are higher order multiples. These sources represent the hitherto youngest sample of stars examined for binarity. I postulate that the dynamical decay of triple or multiple systems leads to strong outflow activity. It is well

  10. Multiple Interval Mapping for Quantitative Trait Loci

    Microsoft Academic Search

    Chen-Hung Kao; Zhao-Bang Zeng; Robert D. Teasdale

    A new statistical method for mapping quantitative trait loci (QTL), called multiple interval mapping (MIM), is presented. It uses multiple marker intervals simultaneously to fit multiple putative QTL directly in the model for mapping QTL. The MIM model is based on Cockerham's model for interpreting genetic parameters and the method of maximum likelihood for estimating genetic parameters. With the MIM

  11. Multiple Sclerosis, Schizophrenia, Temperature and Latitude

    Microsoft Academic Search

    Donald I. Templer; Brent Hughey; Hilda Chalgujian; Michael Lavoie; Neal H. Trent; Paul Sahwell; Dorothy A. Spencer

    Greater geographical latitude was found to be positively associated with multiple sclerosis rates in the United States and Italy. Latitude was found to be positively correlated with schizophrenia rates in Italy. Temperature was negatively correlated with multiple sclerosis in the United States. The exploratory variable of amount of sunlight was inversely related to multiple sclerosis in the United States and

  12. Identifying the Multiple Intelligences of Your Students

    ERIC Educational Resources Information Center

    McClellan, Joyce A.; Conti, Gary J.

    2008-01-01

    One way of addressing individual differences among adult learners is to identify the Multiple Intelligences of the learner. Multiple Intelligences refers to the concept developed by Howard Gardner that challenges the traditional view of intelligence and explains the presence of nine different Multiple Intelligences. The purpose of this study was…

  13. Assessing Elementary Understanding of Multiplication Concepts

    ERIC Educational Resources Information Center

    Smith, Stephanie Z.; Smith, Marvin E.

    2006-01-01

    This article summarizes the basic concepts of multiplication and provides some evidence that the traditional third-grade curriculum and instruction emphasizing memorization of multiplication facts produces much less understanding of the basic concepts of multiplication than a standards-based curriculum and instruction emphasizing construction of…

  14. Note technique Multiplication vgtative du mlze hybride

    E-print Network

    Paris-Sud XI, Université de

    Note technique Multiplication végétative du mélèze hybride (Larix x eurolepis Henry) par bouturage la multiplication végétative «en vrac» repose sur l'obtention d'un nombre de boutures enracinées par pied-mère le plus élevé possible (coefficient de multiplication). Une mé- thode de forçage sous serre

  15. Multiple Instantiation in a Dynamic Workflow Environment

    E-print Network

    Boyer, Edmond

    Multiple Instantiation in a Dynamic Workflow Environment Adnene Guabtni and Fran¸cois Charoy LORIA,charoy}@loria.fr Abstract. Business processes often requires to execute a task multiple time in series or in parallel. In some workflow management systems this possibility is already supported and called "multiple

  16. Deconstructing Calculation Methods, Part 3: Multiplication

    ERIC Educational Resources Information Center

    Thompson, Ian

    2008-01-01

    In this third of a series of four articles, the author deconstructs the primary national strategy's approach to written multiplication. The approach to multiplication, as set out on pages 12 to 15 of the primary national strategy's "Guidance paper" "Calculation" (DfES, 2007), is divided into six stages: (1) mental multiplication using…

  17. Atomicity Improvement for Elliptic Curve Scalar Multiplication

    E-print Network

    Paris-Sud XI, Université de

    Atomicity Improvement for Elliptic Curve Scalar Multiplication Christophe Giraud1 and Vincent@insidefr.com Abstract. In this paper we address the problem of protecting elliptic curve scalar multiplication classical as- sumptions made by scalar multiplication designers and we point out that some of them

  18. Carry Prediction and Selection for Truncated Multiplication

    E-print Network

    Paris-Sud XI, Université de

    Carry Prediction and Selection for Truncated Multiplication Romain Michard*, Arnaud Tisserandt presents an error compensation method for truncated multiplication. From two n-bit operands, the operator multiplication scheme has been synthesized on an FPGA platform. It gives a better accuracy over area ratio than

  19. Multiple Watermarking: A Vector Space Projections Approach

    E-print Network

    Sharma, Gaurav

    Multiple Watermarking: A Vector Space Projections Approach Oktay Altun, Gaurav Sharma and Mark for the insertion of multiple watermarks in images. Instead of an explicitly defined embedding process, the watermark embedding is achieved implicitly by determining a feasible image meeting multiple desired

  20. Hypnosis creates multiple personality: Myth or reality?

    Microsoft Academic Search

    Bennett G. Braun

    1984-01-01

    Since before the turn of the century, multiple personality has been associated with hysteria and hypnosis. The myth that hypnosis can create multiple personality is examined in this paper by reviewing studies that have suggested or implied a casual link between hypnosis and multiple personality. While it is possible that personality fragments can appear under hypnosis, there is no evidence

  1. Functional Multiple-Set Canonical Correlation Analysis

    ERIC Educational Resources Information Center

    Hwang, Heungsun; Jung, Kwanghee; Takane, Yoshio; Woodward, Todd S.

    2012-01-01

    We propose functional multiple-set canonical correlation analysis for exploring associations among multiple sets of functions. The proposed method includes functional canonical correlation analysis as a special case when only two sets of functions are considered. As in classical multiple-set canonical correlation analysis, computationally, the…

  2. Lattice Multiplication in a Preservice Classroom

    ERIC Educational Resources Information Center

    Nugent, Patricia M.

    2007-01-01

    This article discusses the algorithm for multiplication that is referred to as lattice multiplication. Evidence of how the author's preservice students' conceptual understanding of the algorithm grew through the semester is given. In addition, the author extends the conceptualization of the algorithm from the multiplication of whole numbers to the…

  3. obscuration managment for multiple ground target tracking

    E-print Network

    Paris-Sud XI, Université de

    Terrain obscuration managment for multiple ground target tracking Benjamin Pannetier Information Grenoble, France Email: michele.rombaut@lis.inpg.fr Abstract-- Multiple ground targets tracking with a GMTI to track multiple manoeuvring ground targets. However, the case of undetected targets due to terrain

  4. The Multiple Control of Verbal Behavior

    ERIC Educational Resources Information Center

    Michael, Jack; Palmer, David C.; Sundberg, Mark L.

    2011-01-01

    Amid the novel terms and original analyses in Skinner's "Verbal Behavior", the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms "convergent…

  5. ORIGINAL CONTRIBUTION Modification of Multiple Sclerosis Phenotypes

    E-print Network

    Reich, David

    ORIGINAL CONTRIBUTION Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. Oksenberg, PhD Background: In those with multiple sclerosis (MS), Afri- can American individuals have a more ancestry at HLA correlated with dis- ability as measured by the Multiple Sclerosis Severity Score (P .001

  6. Correlation of multiple sclerosis (MS) incidence trends with solar and geomagnetic indices: Time to revise the method of reporting MS epidemiological data

    PubMed Central

    Abdollahi, Fahimeh; Sajedi, Seyed Aidin

    2014-01-01

    Background: Recently, we introduced solar related geomagnetic disturbances (GMD) as a potential environmental risk factor for multiple sclerosis (MS). The aim of this study was to test probable correlation between solar activities and GMD with long-term variations of MS incidence. Methods: After a systematic review, we studied the association betwee n alterations in the solar wind velocity (VSW) and planetary A index (AP, a GMD index) with MS incidence in Tehran and western Greece, during the 23rd solar cycle (1996–2008), by an ecological-correlational study. Results: We found moderate to strong correlations among MS incidence of Tehran with VSW (rS = 0.665, P = 0.013), with 1 year delay, and also with AP (rS = 0.864, P = 0.001) with 2 year delay. There were very strong correlations among MS incidence data of Greece with VSW (r = 0.906, P < 0.001) and with AP (r = 0.844, P = 0.001), both with 1 year lag. Conclusion: It is the first time that a hypothesis has introduced an environmental factor that may describe MS incidence alterations; however, it should be reminded that correlation does not mean necessarily the existence of a causal relationship. Important message of these findings for researchers is to provide MS incidence reports with higher resolution for consecutive years, based on the time of disease onset and relapses, not just the time of diagnosis. Then, it would be possible to further investigate the validity of GMD hypothesis or any other probable environmental risk factors. PMID:25295148

  7. Caustics in special multiple lenses

    E-print Network

    V. Bozza

    2000-01-13

    Despite its mathematical complexity, the multiple gravitational lens can be studied in detail in every situation where a perturbative approach is possible. In this paper, we examine the caustics of a system with a lens very far from the others with respect to their Einstein radii, and a system where mutual distances between lenses are small compared to the Einstein radius of the total mass. Finally we review the case of a planetary system adding some new information (area of caustics, duality and higher order terms).

  8. Multiple station thermal diffusivity instrument

    SciTech Connect

    Wang, H.; Dinwiddie, R.B. [Oak Ridge National Lab., TN (United States); Gaal, P.S. [Anter Corp., Pittsburgh (United States)

    1995-12-31

    A multiple furnace laser flash thermal diffusivity system has been developed. The system is equipped with a movable Nd:Glass laser unit, two IR detectors and furnaces for precise measurements of thermal diffusivity over the temperature range from {minus}150{degree}C to 2500{degree}C. All furnaces can operate in vacuum and inert gas; the environmental effects furnace also supports oxidizing and reducing environments. To increase testing speed the graphite and aluminum furnaces are both equipped with six-sample carousels. Thermal diffusivity measurements of three standard reference materials show excellent results over the entire temperature range.

  9. Macrodystrophia lipomatosa involving multiple nerves.

    PubMed

    Rohilla, Seema; Jain, Nitin; Sharma, Rambaksh; Dhaulakhandi, Dhara B

    2012-03-01

    Macrodystrophia lipomatosa (MDL), a rare congenital disorder, is considered by some to be a localized form of Proteus syndrome. The implication of the PTEN (phosphatase and tensin homolog deleted on chromosome 10) gene in both strengthens this belief. We present a case who had MDL in multiple nerve territories--all on the same side of the body--with hypertrophy of mainly fibroadipose tissue throughout their distribution, thus pointing to a form of localized hemihypertrophy; both hemihypertrophy and lipomatous tumors are components of Proteus syndrome. PMID:21948052

  10. Multiple piece turbine rotor blade

    DOEpatents

    Jones, Russell B; Fedock, John A

    2013-05-21

    A multiple piece turbine rotor blade with a shell having an airfoil shape and secured between a spar and a platform with the spar including a tip end piece. a snap ring fits around the spar and abuts against the spar tip end piece on a top side and abuts against a shell on the bottom side so that the centrifugal loads from the shell is passed through the snap ring and into the spar and not through a tip cap dovetail slot and projection structure.

  11. Therapeutic Advancements in Multiple Myeloma

    PubMed Central

    Gozzetti, Alessandro; Candi, Veronica; Papini, Giulia; Bocchia, Monica

    2014-01-01

    Multiple myeloma survival has significantly improved in the latest years due to a broad spectrum of novel agents available for treatment. The introduction of thalidomide, bortezomib, and lenalidomide together with autologous stem-cell transplantation has considerably increased complete remission rate and progression-free survival resulting ultimately in prolonged survival in myeloma patients. Moreover, novel strategies of treatment such as consolidation and maintenance are being used to further implement responses. Finally, a number of new drugs such as carfilzomib and pomalidomide are already in clinical practice, making the future of myeloma patients brighter. PMID:25237651

  12. Recirculation in multiple wave conversions

    SciTech Connect

    Kaufman, A. N.; Brizard, A.J.; Kaufman, A.N.; Tracy, E.R.

    2008-07-30

    A one-dimensional multiple wave-conversion model is constructed that allows energy recirculation in ray phase space. Using a modular eikonal approach, the connection coefficients for this model are calculated by ray phase-space methods. Analytical results (confirmed numerically) show that all connection coefficients exhibit interference effects that depend on an interference phase, calculated from the coupling constants and the area enclosed by the intersecting rays. This conceptual model, which focuses on the topology of intersecting rays in phase space, is used to investigate how mode conversion between primary and secondary waves is modified by the presence of a tertiary wave.

  13. Multiple personality disorder in Japan.

    PubMed

    Fujii, Y; Suzuki, K; Sato, T; Murakami, Y; Takahashi, T

    1998-06-01

    The aim of this study was to determine whether the features of multiple personality disorder (MPD) in Japan are similar to those in North America, although a wide disparity exists in the prevalence of MPD between the two areas. In order to describe the features of MPD in Japan, we obtained clinical data from MPD case reports, including two of our own cases, published in Japanese academic journals and compared it with the data from other countries. The cases in Japan differed significantly from those in North America in the mean number of personalities and prevalence of sexual and/or physical abuse. PMID:9681581

  14. Spasticity management in multiple sclerosis.

    PubMed

    Hughes, Christina; Howard, Ileana M

    2013-11-01

    Spasticity is a prevalent and potentially disabling symptom common in individuals with multiple sclerosis. Adequate evaluation and management of spasticity requires a careful assessment of the patient's history to determine functional impact of spasticity and potential exacerbating factors, and physical examination to determine the extent of the condition and culpable muscles. A host of options for spasticity management are available: therapeutic exercise, physical modalities, complementary/alternative medicine interventions, oral medications, chemodenervation, and implantation of an intrathecal baclofen pump. Choice of treatment hinges on a combination of the extent of symptoms, patient preference, and availability of services. PMID:24314678

  15. Therapeutic advancements in multiple myeloma.

    PubMed

    Gozzetti, Alessandro; Candi, Veronica; Papini, Giulia; Bocchia, Monica

    2014-01-01

    Multiple myeloma survival has significantly improved in the latest years due to a broad spectrum of novel agents available for treatment. The introduction of thalidomide, bortezomib, and lenalidomide together with autologous stem-cell transplantation has considerably increased complete remission rate and progression-free survival resulting ultimately in prolonged survival in myeloma patients. Moreover, novel strategies of treatment such as consolidation and maintenance are being used to further implement responses. Finally, a number of new drugs such as carfilzomib and pomalidomide are already in clinical practice, making the future of myeloma patients brighter. PMID:25237651

  16. Multiple Sclerosis Society (Grant Tracker) Multiple Sclerosis Society (Grant Tracker) applicant guide June 2012 Page 1

    E-print Network

    Multiple Sclerosis Society (Grant Tracker) Multiple Sclerosis Society (Grant Tracker) applicant guide June 2012 Page 1 2012 INTERNAL USER GUIDE A Guide to the Multiple Sclerosis Society Grant Tracker application system A Quick Guide for applicants applying for funding from the MS Society Multiple Sclerosis

  17. Students' Difficulties With Multiple Representations in Introductory Mechanics

    ERIC Educational Resources Information Center

    Nguyen, Dong-Hai; Rebello, N. Sanjay

    2011-01-01

    Research in physics education indicates that the use of multiple representations in teaching and learning helps students become better problem-solvers. We report on a study to investigate students' difficulties in solving mechanics problems presented in multiple representations. We conducted teaching/learning interviews with 20 students in a…

  18. The Impact of Multiple Fluency Interventions on a Single Subject

    ERIC Educational Resources Information Center

    Morra, Jennifer; Tracey, Dianne H.

    2006-01-01

    This study investigates the effectiveness of multiple fluency interventions on a single subject in grade three. Fluency interventions, including choral reading, echo reading, repeated reading, audio book modeling, and teacher modeling were implemented over a period of eight weeks. Results indicated that using multiple fluency strategies, rather…

  19. Clustering of multiple sclerosis in Galion, Ohio, 1982-1985

    SciTech Connect

    Ingalls, T.H. (Boston Univ. School of Medicine, MA (USA))

    1989-09-01

    Epidemiologic evidence indicates that the outbreak of 30-40 cases of multiple sclerosis and other demyelinating syndromes in Galion, Ohio, USA, during 1982-1985 was related to an excess concentration of heavy-metal wastes, especially of cadmium and chromium in sewage and river water. Both multiple sclerosis and myasthenia gravis were diagnosed by board-certified neurologists.

  20. The criminal responsibility of people with multiple personality disorder.

    PubMed

    Saks, E

    1995-01-01

    Because multiple personality disorder (MPD) is more frequently diagnosed today than in the past, it is likely that more multiples will plead insanity. The courts are in a state of disarray as to how best to respond to these pleas. This article considers multiples' responsibility on three interpretations of the status of their alters: that they are different people; that they are different personalities; or that they are parts of one complex, deeply divided personality. On all three theories multiples are nonresponsible. Nevertheless, three rare circumstances exist under which multiples should be found guilty. The article concludes by indicating the kinds of issues psychiatry might explore to further assist the law in its analysis of the criminal responsibility of multiples. PMID:7652095

  1. Inverse scattering series for multiple attenuation: An example with surface and internal multiples

    SciTech Connect

    Araujo, F.V. [PPPG/Federal Univ. of Bahia, Salvador (Brazil); Weglein, A.B. [Schlumberger Cambridge Research (United Kingdom); Carvalho, P.M. [Petrobras SA, Rio de Janeiro (Brazil); Stolt, R.H.

    1994-12-31

    A multiple attenuation method derived from an inverse scattering series is described. The inversion series approach allows a separation of multiple attenuation subseries from the full series. The surface multiple attenuation subseries was described and illustrated in Carvalho et al. (1991, 1992). The internal multiple attenuation method consists of selecting the parts of the odd terms that are associated with removing only multiply reflected energy. The method, for both types of multiples, is multidimensional and does not rely on periodicity or differential moveout, nor does it require a model of the reflectors generating the multiples. An example with internal and surface multiples will be presented.

  2. Multiple protocol fluorometer and method

    DOEpatents

    Kolber, Zbigniew S. (Shoreham, NY); Falkowski, Paul G. (Stony Brook, NY)

    2000-09-19

    A multiple protocol fluorometer measures photosynthetic parameters of phytoplankton and higher plants using actively stimulated fluorescence protocols. The measured parameters include spectrally-resolved functional and optical absorption cross sections of PSII, extent of energy transfer between reaction centers of PSII, F.sub.0 (minimal), F.sub.m (maximal) and F.sub.v (variable) components of PSII fluorescence, photochemical and non-photochemical quenching, size of the plastoquinone (PQ) pool, and the kinetics of electron transport between Q.sub.a and PQ pool and between PQ pool and PSI. The multiple protocol fluorometer, in one embodiment, is equipped with an excitation source having a controlled spectral output range between 420 nm and 555 nm and capable of generating flashlets having a duration of 0.125-32 .mu.s, an interval between 0.5 .mu.s and 2 seconds, and peak optical power of up to 2 W/cm.sup.2. The excitation source is also capable of generating, simultaneous with the flashlets, a controlled continuous, background illumination.

  3. A multiple-objective optimal exploration strategy

    USGS Publications Warehouse

    Christakos, G.; Olea, R.A.

    1988-01-01

    Exploration for natural resources is accomplished through partial sampling of extensive domains. Such imperfect knowledge is subject to sampling error. Complex systems of equations resulting from modelling based on the theory of correlated random fields are reduced to simple analytical expressions providing global indices of estimation variance. The indices are utilized by multiple objective decision criteria to find the best sampling strategies. The approach is not limited by geometric nature of the sampling, covers a wide range in spatial continuity and leads to a step-by-step procedure. ?? 1988.

  4. A multiple imputation strategy for sequential multiple assignment randomized trials.

    PubMed

    Shortreed, Susan M; Laber, Eric; Scott Stroup, T; Pineau, Joelle; Murphy, Susan A

    2014-10-30

    Sequential multiple assignment randomized trials (SMARTs) are increasingly being used to inform clinical and intervention science. In a SMART, each patient is repeatedly randomized over time. Each randomization occurs at a critical decision point in the treatment course. These critical decision points often correspond to milestones in the disease process or other changes in a patient's health status. Thus, the timing and number of randomizations may vary across patients and depend on evolving patient-specific information. This presents unique challenges when analyzing data from a SMART in the presence of missing data. This paper presents the first comprehensive discussion of missing data issues typical of SMART studies: we describe five specific challenges and propose a flexible imputation strategy to facilitate valid statistical estimation and inference using incomplete data from a SMART. To illustrate these contributions, we consider data from the Clinical Antipsychotic Trial of Intervention and Effectiveness, one of the most well-known SMARTs to date. PMID:24919867

  5. Quantifying the relative importance and potential interactive effects of multiple indices when predicting fire risk and severity in the Western US

    NASA Astrophysics Data System (ADS)

    Keyser, A.; Westerling, A. L.

    2010-12-01

    A long history of fire suppression in the western United States has interrupted the fire regimes of many forest types. This interruption has significantly changed forest structure and ecological function and led to increasingly uncharacteristic fires in terms of size and severity. This project investigated the potential for predicting forest fire severity across the Western US. Identifying areas at risk for fires whose severity is outside the natural fire regime will allow for targeted fuel reduction and mitigation to preserve ecosystem integrity. Our objective was to examine fire regime change, vegetation, fuels, and climate in terms of their utility in predicting forest fire severity in the Western US. How do these factors act separately to influence fire severity and what is their relative importance as co-determinants of fire severity? Is fire severity controlled more by bottom-up (vegetation and fuels) or top-down (climate) factors? We have a mapped fire severity dataset of 4591 large fires spanning twenty-four years (1984-2007) for eleven western states (AZ, CA, CO, ID, MT, NM, NV, OR, UT, WA, WY) as well as a suite of topographic and vegetation data layers from the Landfire project. Our hydro-climate dataset was developed using the VIC hydrologic model with the LDAS parameterization; we thus used the LDAS 1/8° grid to sample our fire severity, topographic, and vegetation datasets. Over our entire dataset, high severity fires make up a small percentage of the overall record. More than 75% of large fires have < 17% of the total fire area classified as high severity. Few years stand out with large fractions of high fire severity across multiple western states; 2002 is one where 6/11 states had significantly more high severity fire area than usual. Regional similarities in inter-annual high severity fire fraction and overall magnitude of high severity fraction occur. For instance, mean annual high severity fraction in large fires in the Southwestern US never reaches 20%. However, mean annual high severity for the Northern Rocky Mountains regularly reaches 30-50%. Initial analyses of the relationship between hydro-climate variables and high fractional fire severity show a number of strong relationships. High severity fraction is positively correlated to topographic complexity, Spring snowpack, and cumulative precipitation for the 12-month prior period and the 12-month period ending 6-months prior to the month of the fire. High severity fraction is negatively correlated to summer moisture deficit, average spring temperature, and cumulative adjusted moisture deficit for 12 months prior to the month of fire and the 12-month period ending 6 months prior to the fire. These initial correlations counter our hypothesis that high severity fire would be positively correlated to drier conditions. This hypothesis is based the importance of fuel moisture to fire severity and also previous results for California. We will present a final predictive model of fire severity as well as analysis as to whether patterns observed are driven more by bottom-up or top-down controls.

  6. Congenital Abnormalities and Multiple Sclerosis

    PubMed Central

    2010-01-01

    Background There is a strong maternal parent-of-origin effect in determining susceptibility to multiple sclerosis (MS). One hypothesis is that an abnormal intrauterine milieu leading to impaired fetal development could plausibly also result in increased susceptibility to MS. A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly. Methods We investigated whether or not congenital anomalies are associated with MS in a population-based cohort. We identified 7063 MS index cases and 2655 spousal controls with congenital anomaly information from the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). Results The frequency of congential anomalies were compared between index cases and controls. No significant differences were found. Conclusions Congenital anomalies thus do not appear to be associated with MS. However, we did not have complete data on types and severity of congenital anomalies or on maternal birth history and thus this study should be regarded as preliminary. PMID:21080921

  7. Multiple thoracolithiasis: An incidental finding

    PubMed Central

    Rawstorne, E; Muzaffar, J; Hawari, M; Naidu, P; Steyn, R

    2012-01-01

    Thoracoliths are rare benign intrapleural fibrotic structures with a necrotic fat core. There are 19 previous reported cases in the literature. This case report presents for the first time, a patient with two thoracoliths within the same hemithorax. Both lesions were identified incidentally in the left hemithorax by computed tomography and remained in the same position on repeat imaging. The lesions were removed by a video-assisted thoracic surgery approach. Histology revealed a 20mm and a 14mm lesion, with a fibrotic dense collagen shell surrounding a non-viable necrotic fat core. This case demonstrates that thoracolithiasis is a rare differential diagnosis for incidental multiple non-mobile lesions within the thorax. PMID:24960759

  8. Vitamin D and multiple sclerosis

    PubMed Central

    Harandi, Ali Amini; Pakdaman, Hossein; Sahraian, Mohammad Ali

    2014-01-01

    Multiple sclerosis (MS) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immune system is under the influence of vitamin D which as a modulator of immune response could play a role in autoimmune diseases including MS. Deficiency of vitamin D or variations in DNA sequence (polymorphism) of vitamin D receptor gene diminishes its optimal function on immune system that consequently could lead to increasing risk of MS. However, its role in development and modulating the course of MS is still under investigation. In this review we aimed to discuss the role of vitamin D in body, immune system and consequently altering the risk of MS. PMID:24800040

  9. Vitamin D and multiple sclerosis.

    PubMed

    Harandi, Asghar Amini; Harandi, Ali Amini; Pakdaman, Hossein; Sahraian, Mohammad Ali

    2014-01-01

    Multiple sclerosis (MS) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immune system is under the influence of vitamin D which as a modulator of immune response could play a role in autoimmune diseases including MS. Deficiency of vitamin D or variations in DNA sequence (polymorphism) of vitamin D receptor gene diminishes its optimal function on immune system that consequently could lead to increasing risk of MS. However, its role in development and modulating the course of MS is still under investigation. In this review we aimed to discuss the role of vitamin D in body, immune system and consequently altering the risk of MS. PMID:24800040

  10. [The epidemiology of multiple myeloma].

    PubMed

    Suzuki, Kenshi; Takahashi, Haruka

    2015-01-01

    We investigated epidemiology of multiple myeloma (MM), referring to recent papers. This article includes three points: 1) the progression rate of monoclonal gammopathy of undetermined significance (MGUS) to MM, 2) the effect of radiation to prevalence of MM, and 3) secondary malignancy after chemotherapy used to treat MM. The risk of progression from MGUS to MM is 1% per year. The researches of atomic bomb showed that there is no increase of risk of MM after radiation exposure. In contrast, studies investigating workers in nuclear power plants point out that radiation exposure over 50 mSv increases risk of MM. The incidence of secondary malignancy after chemotherapy used to treat MM was about 5%. This article will help to review recent researches about epidemiology of MM. PMID:25626296

  11. Multiple importance sampling for PET.

    PubMed

    Szirmay-Kalos, Laszló; Magdics, Milán; Tóth, Balázs

    2014-04-01

    This paper proposes the application of multiple importance sampling in fully 3-D positron emission tomography to speed up the iterative reconstruction process. The proposed method combines the results of lines of responses (LOR) driven and voxel driven projections keeping their advantages, like importance sampling, performance and parallel execution on graphics processing units. Voxel driven methods can focus on point like features while LOR driven approaches are efficient in reconstructing homogeneous regions. The theoretical basis of the combination is the application of the mixture of the samples generated by the individual importance sampling methods, emphasizing a particular method where it is better than others. The proposed algorithms are built into the Tera-tomo system. PMID:24710165

  12. Multiple-stage integrating accelerometer

    NASA Astrophysics Data System (ADS)

    Devaney, H. F.

    1984-06-01

    An accelerometer assembly is provided for use in activating a switch in response to multiple acceleration pulses in series. The accelerometer includes a housing forming a chamber. An inertial mass or piston is slidably disposed in the chamber and spring biased toward a first or reset position. A damping system is also provided to damp piston movement in response to first and subsequent acceleration pulses. Additionally, a cam, including a Z-shaped slot, and cooperating follower pin slidably received therein are mounted to the piston and the housing. The middle or cross-over leg of the Z-shaped slot cooperates with the follower pin to block or limit piston movement and prevent switch activation in response to a lone acceleration pulse. The switch of the assembly is only activated after two or more separate acceleration pulses are sensed and the piston reaches the end of the chamber opposite the reset position.

  13. Hereditary Multiple Exostoses with Pseudoaneurysm

    SciTech Connect

    Al-Hadidy, Azmy M. [Jordan University Hospital, University of Jordan, Department of Diagnostic Radiology (Jordan)], E-mail: ahadidy@ju.edu.jo; Al-Smady, Moa'ath M. [Jordan University Hospital, University of Jordan, Department of Vascular Surgery (Jordan); Haroun, Azmi A. [Jordan University Hospital, University of Jordan, Department of Diagnostic Radiology (Jordan); Hamamy, Hanan A. [National Institute for Diabetes Endocrinology and Genetics (Jordan); Ghoul, Suha M. [Jordan University Hospital, University of Jordan, Department of Diagnostic Radiology (Jordan); Shennak, Akram O. [Jordan University Hospital, University of Jordan, Department of Orthopedic Surgery (Jordan)

    2007-06-15

    A 16-year-old male patient with hereditary multiple exostoses (HME) was found to have a pseudoaneurysm of the left popliteal artery caused by osteochondroma in the lower femur. The diagnosis was confirmed by ultrasound, magnetic resonance imaging and magnetic resonance angiography without the need to perform an angiogram. The osteochondroma was excised and the popliteal artery was repaired with a saphenous graft. Vascular complications are extremely rare in HME, pseudoaneurysm being the most common and mostly located in the popliteal artery. This complication should be considered in young HME patients with a mass at the knee region. The radiological spectrum of investigations allows the diagnosis of this complication with proper and less invasive management procedures for the patient.

  14. Painful and involuntary Multiple Sclerosis

    PubMed Central

    Bagnato, Francesca; Centonze, Diego; Galgani, Simonetta; Grasso, Maria Grazia; Haggiag, Shalom; Strano, Stefano

    2010-01-01

    Importance of the field Pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions may occur in patients with multiple sclerosis (MS). Areas covered in the field In the present review we attempt to summarize the current knowledge on the impact that pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions have in patients with MS. What the reader will gain The current understanding on pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions and future research perspectives to expand the knowledge of this field. Take home message To effectively manage MS it is essential that these symptoms are recognised as early as possible and treated by a rehabilitative multidisciplinary approach, based on proven scientific evidence. PMID:21323633

  15. Lightweight multiple output converter development

    NASA Technical Reports Server (NTRS)

    Kisch, J. J.; Martinelli, R. M.

    1978-01-01

    A high frequency, multiple output power conditioner was developed and breadboarded using an eight-stage capacitor diode voltage multiplier to provide +1200 Vdc, and a three-stage for -350 Vdc. In addition, two rectifier bridges were capacitively coupled to the eight-stage multiplier to obtain 0.5 and 0.65 a dc constant current outputs referenced to +1200 Vdc. Total power was 120 watts, with an overall efficiency of 85 percent at the 80 kHz operating frequency. All outputs were regulated to three percent or better, with complete short circuit protection. The power conditioner component weight and efficiency were compared to the equivalent four outputs of the 10 kHz conditioner for the 8 cm ion engine. Weight reduction for the four outputs was 557 grams; extrapolated in the same ratio to all nine outputs, it would be 1100 to 1400 grams.

  16. Oral agents in multiple sclerosis.

    PubMed

    Lorefice, L; Fenu, G; Frau, J; Coghe, G C; Marrosu, M G; Cocco, E

    2015-01-01

    Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system. Diseasemodifying drugs licensed for MS treatment have been developed to reduce relapse rates and halt disease progression. The majority of current MS drugs involve regular, parenteral administration, affecting long-term adherence and thus reducing treatment efficacy. Over the last two decades great progress has been made towards developing new MS therapies with different modes of action and biologic effects. In particular, oral drugs have generated much interest because of their convenience and positive impact on medication adherence. Fingolimod was the first launched oral treatment for relapsing-remitting MS; recently, Teriflunomide and Dimethyl fumarate have also been approved as oral disease-modifying agents. In this review, we summarize and discuss the history, pharmacodynamics, efficacy, and safety of oral agents that have been approved or are under development for the selective treatment of MS. PMID:25924620

  17. 2014 Multiple Sclerosis Therapeutic Update

    PubMed Central

    Cree, Bruce A. C.

    2014-01-01

    Rapid advances are occurring in multiple sclerosis disease modifying therapies. Recent therapeutic advances include modifications to improve tolerability of existing products (e.g. interferon beta and glatiramer acetate), development of novel anti-neuroinflammatory medications (e.g. fingolimod, teriflunomide and dimethyl fumarate, daclizumab, alemtuzumab, ocrelizumab) and investigation of treatments in progressive MS (e.g. natalizumab, mastinib, natalizumab, siponimod). The impact of vitamin D supplementation on the disease course in relapsing MS patients is also being studied in several clinical trials. This article reviews the current state of the field with a forward look to the next phase of MS research that could focus on strategies to promote remyelination and provide neuronal protection. PMID:24707333

  18. Naming Game with Multiple Hearers

    NASA Astrophysics Data System (ADS)

    Li, Bing; Chen, Guanrong; Chow, Tommy W. S.

    2013-05-01

    A new model called Naming Game with Multiple Hearers (NGMH) is proposed in this paper. A naming game over a population of individuals aims to reach consensus on the name of an object through pair-wise local interactions among all the individuals. The proposed NGMH model describes the learning process of a new word, in a population with one speaker and multiple hearers, at each interaction towards convergence. The characteristics of NGMH are examined on three types of network topologies, namely ER random-graph network, WS small-world network, and BA scale-free network. Comparative analysis on the convergence time is performed, revealing that the topology with a larger average (node) degree can reach consensus faster than the others over the same population. It is found that, for a homogeneous network, the average degree is the limiting value of the number of hearers, which reduces the individual ability of learning new words, consequently decreasing the convergence time; for a scale-free network, this limiting value is the deviation of the average degree. It is also found that a network with a larger clustering coefficient takes longer time to converge; especially a small-word network with smallest rewiring possibility takes longest time to reach convergence. As more new nodes are being added to scale-free networks with different degree distributions, their convergence time appears to be robust against the network-size variation. Most new findings reported in this paper are different from that of the single-speaker/single-hearer naming games documented in the literature.

  19. Daclizumab therapy for multiple sclerosis.

    PubMed

    Bielekova, Bibiana

    2013-01-01

    Daclizumab is a humanized monoclonal antibody of IgG1 subtype that binds to the Tac epitope on the interleukin-2 (IL-2) receptor ?-chain (CD25), thus, effectively blocking the formation of the high-affinity IL-2 receptor. Because the high-affinity IL-2 receptor signaling promotes expansion of activated T cells in vitro, daclizumab was designed as a therapy that selectively inhibits T-cell activation. Assuming the previous statement, daclizumab received regulatory approval as add-on therapy to standard immunosuppressive regimen for the prevention of acute allograft rejection in renal transplantation. Based on its putative mechanism of action (MOA), daclizumab represented an ideal therapy for T-cell-mediated autoimmune diseases and was subsequently tested in inflammatory uveitis and multiple sclerosis (MS). In both of these diseases, daclizumab therapy significantly inhibited target organ inflammation. Mechanistic studies in MS demonstrated that the MOA of daclizumab is surprisingly broad and that the drug exerts unexpected effects on multiple components of the innate immune system. Specifically, daclizumab dramatically expands and activates immunoregulatory CD56(bright) NK cells, which gain access to the intrathecal compartment in MS and can kill autologous activated T cells. Daclizumab also blocks trans-presentation of IL-2 by mature dendritic cells to primed T cells, resulting in profound inhibition of antigen-specific T cells. Finally, daclizumab modulates the development of innate lymphoid cells. In conclusion, daclizumab therapy, which is currently in phase III testing for inflammatory MS, has a unique MOA that does not limit migration of immune cells into the intrathecal compartment, but rather provides multifactorial immunomodulatory effects with resultant inhibition of MS-related inflammation. PMID:23055048

  20. Interactive local search for multiple-criteria scheduling 

    E-print Network

    Li, Shijun

    1998-01-01

    Multiple-criteria scheduling refers to the scheduling problem in which the goodness of a schedule is evaluated using more than one performance criterion. Multiple-criteria scheduling is classified as multiple-attribute scheduling (MAS) and multiple-objective...

  1. Interactive local search for multiple-criteria scheduling

    E-print Network

    Li, Shijun

    1998-01-01

    Multiple-criteria scheduling refers to the scheduling problem in which the goodness of a schedule is evaluated using more than one performance criterion. Multiple-criteria scheduling is classified as multiple-attribute scheduling (MAS) and multiple...

  2. Improving Multiple Fault Diagnosability using Possible Conflicts

    NASA Technical Reports Server (NTRS)

    Daigle, Matthew J.; Bregon, Anibal; Biswas, Gautam; Koutsoukos, Xenofon; Pulido, Belarmino

    2012-01-01

    Multiple fault diagnosis is a difficult problem for dynamic systems. Due to fault masking, compensation, and relative time of fault occurrence, multiple faults can manifest in many different ways as observable fault signature sequences. This decreases diagnosability of multiple faults, and therefore leads to a loss in effectiveness of the fault isolation step. We develop a qualitative, event-based, multiple fault isolation framework, and derive several notions of multiple fault diagnosability. We show that using Possible Conflicts, a model decomposition technique that decouples faults from residuals, we can significantly improve the diagnosability of multiple faults compared to an approach using a single global model. We demonstrate these concepts and provide results using a multi-tank system as a case study.

  3. Evaluating multiple coordinated windows for programming workstations

    NASA Technical Reports Server (NTRS)

    Shneiderman, B.; Grantham, C.; Norman, K.; Rogers, J.; Roussopoulos, N.

    1983-01-01

    Programmers might benefit from larger screens with multiple windows or multiple screens, especially if convenient coordination among screens are arranged. Uses for multiple coordinated displays in a programmers workstation are explored. Initial efforts focus on the potential applications, a command language for coordinating the displays, and the psychological basis for effective utilization so as to avoid information overload. Subsequent efforts will be devoted to implementing the concepts and performing controlled psychologically oriented experiments to validate the hypotheses.

  4. Multiple Scattering, Underlying Event, and Minimum Bias

    E-print Network

    Gosta Gustafson

    2007-12-12

    In this talk I first discuss the experimental evidence for multiple scattering and the properties of the underlying event. The extensive analyses by Rick Field of data from CDF cannot be reconciled with traditional wisdom concerning multiple collisions and the AGK cutting rules. Data seem to imply some kind of color recombination or unexpectedly strong effects from pomeron vertices. I then discuss theoretical ideas concerning the relation between multiple collisions and unitarity: the AGK rules, IP loops, dipole cascade models and diffraction.

  5. The angular gyrus: multiple functions and multiple subdivisions.

    PubMed

    Seghier, Mohamed L

    2013-02-01

    There is considerable interest in the structural and functional properties of the angular gyrus (AG). Located in the posterior part of the inferior parietal lobule, the AG has been shown in numerous meta-analysis reviews to be consistently activated in a variety of tasks. This review discusses the involvement of the AG in semantic processing, word reading and comprehension, number processing, default mode network, memory retrieval, attention and spatial cognition, reasoning, and social cognition. This large functional neuroimaging literature depicts a major role for the AG in processing concepts rather than percepts when interfacing perception-to-recognition-to-action. More specifically, the AG emerges as a cross-modal hub where converging multisensory information is combined and integrated to comprehend and give sense to events, manipulate mental representations, solve familiar problems, and reorient attention to relevant information. In addition, this review discusses recent findings that point to the existence of multiple subdivisions in the AG. This spatial parcellation can serve as a framework for reporting AG activations with greater definition. This review also acknowledges that the role of the AG cannot comprehensibly be identified in isolation but needs to be understood in parallel with the influence from other regions. Several interesting questions that warrant further investigations are finally emphasized. PMID:22547530

  6. Coulomb pairing resonances in multiple-ring aromatic molecules

    E-print Network

    Huber, D L

    2015-01-01

    We present an analysis of the Coulomb pairing resonances observed in photo-double-ionization studies of CnHm aromatic molecules with multiple benzene-like rings. It is applied to naphthalene, anthracene, phenanthrene, pyrene and coronene, all of which have six-member rings, and azulene which is comprised of a five-member and a seven-member ring. There is a high energy resonance at ~ 40 eV that is found in all of the molecules cited and is associated with paired electrons localized on carbon sites on the perimeter of the molecule, each of which having two carbon sites as nearest neighbors. The low energy resonance at 10 eV, which is found only in pyrene and coronene, is attributed to the formation of paired electrons localized on arrays of interior carbon atoms that have the point symmetry of the molecule with each carbon atom having three nearest neighbors. The origin of the anomalous increase in the doubly charged to singly charged parent-ion ratio that is found above the 40 eV resonance in all of the cited ...

  7. MULTIPLE qZETA VALUES DAVID M. BRADLEY

    E-print Network

    Bradley, David

    MULTIPLE q­ZETA VALUES DAVID M. BRADLEY Abstract. We introduce a q­analog of the multiple harmonic series commonly referred to as multiple zeta values. The multiple q­zeta values satisfy a q­stu#e multiplication rule analogous to the stu#e multiplication rule arising from the series representation of ordinary

  8. Quantifying the power of multiple event interpretations

    E-print Network

    Yang-Ting Chien; David Farhi; David Krohn; Andrew Marantan; David Lopez Mateos; Matthew Schwartz

    2014-07-10

    A number of methods have been proposed recently which exploit multiple highly-correlated interpretations of events, or of jets within an event. For example, Qjets reclusters a jet multiple times and telescoping jets uses multiple cone sizes. Previous work has employed these methods in pseudo-experimental analyses and found that, with a simplified statistical treatment, they give sizable improvements over traditional methods. In this paper, the improvement gain from multiple event interpretations is explored with methods much closer to those used in real experiments. To this end, we derive a generalized extended maximum likelihood procedure. We study the significance improvement in Higgs to bb with both this method and the simplified method from previous analysis. With either method, we find that using multiple jet radii can provide substantial benefit over a single radius. Another concern we address is that multiple event interpretations might be exploiting similar information to that already present in the standard kinematic variables. By examining correlations between kinematic variables commonly used in LHC analyses and invariant masses obtained with multiple jet reconstructions, we find that using multiple radii is still helpful even on top of standard kinematic variables when combined with boosted decision trees. These results suggest that including multiple event interpretations in a realistic search for Higgs to bb would give additional sensitivity over traditional approaches.

  9. Algebraic Expressions - Number Line Model for Multiplication

    NSDL National Science Digital Library

    EDC in Maine

    2010-08-26

    This interactive Java learning tool allows a teacher to demonstrate and explore with students number line models for two simple variable expressions for multiplication. The first expression is a variable with an understood coefficient of one and the second is the multiplication of a variable by a coefficient. Sliders are used to select the value of the variable (-10 to 10) and the coefficient (0 to 10). Check boxes show or hide the algebraic expression, the expression with substitution, the notation shown for multiplication, the result, and a model for the multiplication, shown as jumps along a number line.

  10. Multiplicative Lévy processes: Itô versus Stratonovich interpretation

    NASA Astrophysics Data System (ADS)

    Srokowski, Tomasz

    2009-11-01

    Langevin equation with a multiplicative stochastic force is considered. That force is uncorrelated, it has the Lévy distribution and the power-law intensity. The Fokker-Planck equations, which correspond both to the Itô and Stratonovich interpretation, are presented. They are solved for the case without drift and for the harmonic oscillator potential. The variance is evaluated; it is always infinite for the Itô case whereas for the Stratonovich one it can be finite and rise with time slower that linearly, which indicates subdiffusion. Analytical results are compared with numerical simulations.

  11. Environmental factors in multiple sclerosis.

    PubMed

    Pantazou, Vasiliki; Schluep, Myriam; Du Pasquier, Renaud

    2015-04-01

    Although multiple sclerosis (MS) is recognized as a disorder involving the immune system, the interplay of environmental factors and individual genetic susceptibility seems to influence MS onset and clinical expression, as well as therapeutic responsiveness. Multiple human epidemiological and animal model studies have evaluated the effect of different environmental factors, such as viral infections, vitamin intake, sun exposure, or still dietary and life habits on MS prevalence. Previous Epstein-Barr virus infection, especially if this infection occurs in late childhood, and lack of vitamin D (VitD) currently appear to be the most robust environmental factors for the risk of MS, at least from an epidemiological standpoint. Ultraviolet radiation (UVR) activates VitD production but there are also some elements supporting the fact that insufficient UVR exposure during childhood may represent a VitD-independent risk factor of MS development, as well as negative effect on the clinical and radiological course of MS. Recently, there has been a growing interest in the gut-brain axis, a bidirectional neuro-hormonal communication system between the intestinal microbiota and the central nervous system (CNS). Indeed, components of the intestinal microbiota may be pro-inflammatory, promote the migration of immune cells into the CNS, and thus be a key parameter for the development of autoimmune disorders such as MS. Interestingly most environmental factors seem to play a role during childhood. Thus, if childhood is the most fragile period to develop MS later in life, preventive measures should be applied early in life. For example, adopting a diet enriched in VitD, playing outdoor and avoiding passive smoking would be extremely simple measures of primary prevention for public health strategies. However, these hypotheses need to be confirmed by prospective evaluations, which are obviously difficult to conduct. In addition, it remains to be determined whether and how VitD supplementation in adult life would be useful in alleviating the course of MS, once this disease has already started. A better knowledge of the influence of various environmental stimuli on MS risk and course would certainly allow the development of add-on therapies or measures in parallel to the immunotherapies currently used in MS. PMID:25744944

  12. Stellar Multiplicity of the Open Cluster Melotte 111

    NASA Astrophysics Data System (ADS)

    Guerrero, C. A.; Orlov, V. G.; Monroy-Rodríguez, M. A.; Borges Fernandes, M.

    2015-07-01

    We present a high-angular resolution survey for the search of binary and multiple stars in the Galactic open cluster Melotte 111. Combining our own speckle-interferometric observations with data taken from the literature, we found a ratio of the number of single to multiple stars to be 29:8:0:0:0:1 for the most probable members, indicating a multiplicity fraction for this cluster of 25.6% ± 2%. We also observed field stars in the vicinity of the cluster and estimated a ratio of multiplicities of 286:17:1:0:0:0:1 (between one and seven companions), equivalent to a multiplicity fraction of 5.9% ± 3%. We showed that the cumulative distribution of separations for our sample stars is in agreement with Öpik’s law.

  13. Multiple-layer Radiation Absorber

    NASA Astrophysics Data System (ADS)

    Baker, Robert M. L.; Baker, Bonnie Sue

    A structure is discussed for absorbing incident radiation, either electromagnetic (EM) or sound. Such a surface structure is needed, for example, in a highly sensitive high-frequency gravitational wave or HFGW detector such as the Li-Baker. The multi-layer absorber, which is discussed, is constructed with metamaterial [MM] layer or layers on top. This MM is configured for a specific EM or sound radiation frequency band, which absorbs incident EM or sound radiation without reflection. Below these top MM layers is a substrate of conventional EM-radiation absorbing or acoustical absorbing reflective material, such as an array of pyramidal foam absorbers. Incident radiation is partially absorbed by the MM layer or layers, and then it is more absorbed by the lower absorbing and reflecting substrate. The remaining reflected radiation is even further absorbed by the MM layers on its "way out_ so that essentially all of the incident radiation is absorbed _ a nearly perfect black-body absorber. In a HFGW detector a substrate, such as foam absorbers, may outgas into a high vacuum and reduce the capability of the vacuum-producing equipment, however, the layers above this lowest substrate will seal the absorbing and reflecting substrate from any external vacuum. The layers also serve to seal the absorbing material against air or water flow past the surfaces of aircraft, watercraft or submarines. Other applications for such a multiple-level radiation absorber include stealth aircraft, missiles and submarines.

  14. Animal models of Multiple Sclerosis.

    PubMed

    Procaccini, Claudio; De Rosa, Veronica; Pucino, Valentina; Formisano, Luigi; Matarese, Giuseppe

    2015-07-15

    Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which involves a complex interaction between immune system and neural cells. Animal modeling has been critical for addressing MS pathogenesis. The three most characterized animal models of MS are (1) the experimental autoimmune/allergic encephalomyelitis (EAE); (2) the virally-induced chronic demyelinating disease, known as Theiler?s murine encephalomyelitis virus (TMEV) infection and (3) the toxin-induced demyelination. All these models, in a complementary way, have allowed to reach a good knowledge of the pathogenesis of MS. Specifically, EAE is the model which better reflects the autoimmune pathogenesis of MS and is extremely useful to study potential experimental treatments. Furthermore, both TMEV and toxin-induced demyelination models are suitable for characterizing the role of the axonal injury/repair and the remyelination process in MS. In conclusion, animal models, despite their limitations, remain the most useful instrument for implementing the study of MS. PMID:25823807

  15. Fibronectin in multiple sclerosis lesions.

    PubMed Central

    Sobel, R. A.; Mitchell, M. E.

    1989-01-01

    Cryostat sections of central nervous system (CNS) tissues of patients with multiple sclerosis (MS) and other CNS diseases were stained with antibodies to fibronectin, a macrophage fibronectin receptor component, fibrin/fibrinogen, and albumin using immunoperoxidase. In active, but not inactive, MS plaques vessel fibronectin was increased (to approximately 57% of Factor VIII+ vessels) over uninvolved MS and normal control white matter (P less than 0.001 for both). Fibronectin was primarily localized to vessel walls and amount of staining correlated with degree of inflammation. Active plaques and necrotic lesions also had extracellular fibronectin and fibrin/ogen. These molecules and the fibronectin receptor were found on macrophages. Albumin was more widely and diffusely distributed in lesions than fibronectin. Thus, in addition to extravasation from damaged vessels, fibronectin may be deposited on or synthesized by endothelial cells and macrophages in the CNS. Fibronectin could facilitate monocyte adhesion to endothelial cell luminal surfaces, promote migration of mononuclear cells, and enhance myelin phagocytosis in MS lesions. Images Figure 1 Figure 2 PMID:2528301

  16. Multiple pathways regulate shoot branching

    PubMed Central

    Rameau, Catherine; Bertheloot, Jessica; Leduc, Nathalie; Andrieu, Bruno; Foucher, Fabrice; Sakr, Soulaiman

    2015-01-01

    Shoot branching patterns result from the spatio-temporal regulation of axillary bud outgrowth. Numerous endogenous, developmental and environmental factors are integrated at the bud and plant levels to determine numbers of growing shoots. Multiple pathways that converge to common integrators are most probably involved. We propose several pathways involving not only the classical hormones auxin, cytokinins and strigolactones, but also other signals with a strong influence on shoot branching such as gibberellins, sugars or molecular actors of plant phase transition. We also deal with recent findings about the molecular mechanisms and the pathway involved in the response to shade as an example of an environmental signal controlling branching. We propose the TEOSINTE BRANCHED1, CYCLOIDEA, PCF transcription factor TB1/BRC1 and the polar auxin transport stream in the stem as possible integrators of these pathways. We finally discuss how modeling can help to represent this highly dynamic system by articulating knowledges and hypothesis and calculating the phenotype properties they imply. PMID:25628627

  17. Multiple access mass storage network

    SciTech Connect

    Wentz, D.L. Jr.

    1980-01-01

    The Multi-Access Storage Subnetwork (MASS) is the latest addition to the Octopus computer network at Lawrence Livermore Laboratory. The subnetwork provides shared mass storage for the Laboratory's multiple-host computer configuration. A Control Data Corp. 38500 Mass Storage facility is interfaces by MASS to the large, scientific worker computers to provide an on-line capacity of 1 trillion bits of user-accessible data. The MASS architecture offers a very high performance approach to the management of large data storage, as well as a high degree of reliability needed for operation in the Laboratory's timesharing environment. MASS combines state-of-the-art digital hardware with an innovative system philosophy. The key LLL design features of the subnetwork that contribute to the high performance include the following: a data transmission scheme that provides a 40-Mbit/s channel over distances of up to 1000 ft, a large metal-oxide-semiconductor (MOS) memory buffer controlled by a 24-port memory multiplexer with an aggregate data rate of 280 Mbit/s, and a set of high-speed microprocessor-based controllers driving the commercial mass storage units. Reliability of the system is provided by a completely redundant network, including two control minicomputer systems. Also enhancing reliability is error detection and correction in the MOS memory. A hardware-generated checksum is carried with each file throughout the entire network to ensure integrity of user files. 6 figures, 1 table.

  18. Islamic fasting and multiple sclerosis

    PubMed Central

    2014-01-01

    Background Month-long daytime Ramadan fasting pose s major challenges to multiple sclerosis (MS) patients in Muslim countries. Physicians should have practical knowledge on the implications of fasting on MS. We present a summary of database searches (Cochrane Database of Systematic Reviews, PubMed) and a mini-symposium on Ramadan fasting and MS. In this symposium, we aimed to review the effect of fasting on MS and suggest practical guidelines on management. Discussion In general, fasting is possible for most stable patients. Appropriate amendment of drug regimens, careful monitoring of symptoms, as well as providing patients with available evidence on fasting and MS are important parts of management. Evidence from experimental studies suggests that calorie restriction before disease induction reduces inflammation and subsequent demyelination and attenuates disease severity. Fasting does not appear to have unfavorable effects on disease course in patients with mild disability (Expanded Disability Status Scale (EDSS) score ?3). Most experts believed that during fasting (especially in summer), some MS symptoms (fatigue, fatigue perception, dizziness, spasticity, cognitive problems, weakness, vision, balance, gait) might worsen but return to normal levels during feasting. There was a general consensus that fasting is not safe for patients: on high doses of anti-convulsants, anti-spastics, and corticosteroids; with coagulopathy or active disease; during attacks; with EDSS score ?7. Summary These data suggest that MS patients should have tailored care. Fasting in MS patients is a challenge that is directly associated with the spiritual belief of the patient. PMID:24655543

  19. Neuroendocrine Immunoregulation in Multiple Sclerosis

    PubMed Central

    Lee, Wai-Ping; Berneman, Zwi N.

    2013-01-01

    Currently, it is generally accepted that multiple sclerosis (MS) is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin. In this respect, intrinsic or extrinsic factors such as emotional, psychological, traumatic, or inflammatory stress as well as a variety of other lifestyle interventions can influence the neuroendocrine system. On its turn, it has been demonstrated that the neuroendocrine system has immunomodulatory potential. Moreover, the neuroendocrine and immune systems communicate bidirectionally via shared receptors and shared messenger molecules, variously called hormones, neurotransmitters, or cytokines. Discrepancies at any level can therefore lead to changes in susceptibility and to severity of several autoimmune and inflammatory diseases. Here we provide an overview of the complex system of crosstalk between the neuroendocrine and immune system as well as reported dysfunctions involved in the pathogenesis of autoimmunity, including MS. Finally, possible strategies to intervene with the neuroendocrine-immune system for MS patient management will be discussed. Ultimately, a better understanding of the interactions between the neuroendocrine system and the immune system can open up new therapeutic approaches for the treatment of MS as well as other autoimmune diseases. PMID:24382974

  20. Multiple sclerosis: pathogenesis and treatment.

    PubMed

    Loma, Ingrid; Heyman, Rock

    2011-09-01

    Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease of the central nervous system. It affects approximately 400,000 people in the United States and onset is usually during young adulthood. There are four clinical forms of MS, of which relapsing remitting type is the most common. As the etiology of MS is unknown, finding a cure will remain challenging. The main mechanism of injury appears to be inflammation and 8 agents are now FDA approved to help control MS. These agents for relapsing forms of MS target different parts of the immune system, with the end goal of decreasing and avoiding further inflammation. No agents are FDA approved for the primary progressive version of MS. FDA approved agents include four preparations of interferon ? (Avonex, Rebif, Betaseron and Extavia), glatiramer acetate (Copaxone), mitoxantrone (Novantrone), natalizumab (Tysabri) and fingolimod (Gilenya). There are several drug undergoing phase II and III trials. The heterogeneity of the MS disease process, individual patient response, and medication toxicities continue to challenge the treating physician. PMID:22379455

  1. BG-12 in multiple sclerosis.

    PubMed

    Phillips, J Theodore; Fox, Robert J

    2013-02-01

    Dimethyl fumarate (DMF) is an orally administered agent that has been used for over 40 years for the treatment of psoriasis. Recent work demonstrates both DMF immunomodulatory and neuroprotective actions in vitro and in animal models of autoreactive central nervous system inflammation and neurodegeneration. DMF acts through chemical modification of the repressor protein Keap1, allowing stabilization and nuclear translocation of the transcription factor Nrf2, with subsequent downstream activation of a cascade of several cytoprotective and antioxidant pathways. Additionally, suppression of transcription factor NF-?B-mediated proinflammatory signaling results in the inhibition of proinflammatory responses and induction of anti-inflammatory cytokines. BG-12 is an orally administered, enteric-coated microtablet preparation of DMF. In two phase III, relapsing-remitting multiple sclerosis (MS) trials, BG-12 led to a 44 to 53% reduction in annualized relapse rate and a 71 to 85% reduction in new T2 lesions on magnetic resonance imaging. The most common side effects of BG-12 are cutaneous flushing and gastrointestinal symptoms, with the highest incidence in the first month after starting treatment. No serious safety signals were seen during the phase II and III trials, including no increased risk of opportunistic infections or cancer. Altogether, BG-12's novel mechanism of action appears to provide a favorable balance of efficacy, safety, and tolerability for treatment of relapsing MS. PMID:23709213

  2. Multiple-bandwidth photoacoustic tomography.

    PubMed

    Ku, Geng; Wang, Xueding; Stoica, George; Wang, Lihong V

    2004-04-01

    Photoacoustic tomography, also referred to as optoacoustic tomography, employs short laser pulses to generate ultrasonic waves in biological tissues. The reconstructed images can be characterized by the convolution of the structure of samples, the laser pulse and the impulse response of the ultrasonic transducer used for detection. Although the laser-induced ultrasonic waves cover a wide spectral range, a single transducer can receive only part of the spectrum because of its limited bandwidth. To systematically analyse this problem, we constructed a photoacoustic tomographic system that uses multiple ultrasonic transducers simultaneously, each at a different central frequency. The photoacoustic images associated with the different transducers were compared and analysed. The system was tested by imaging both mouse brains and phantom samples. The vascular vessels in the brain were revealed by all of the transducers, but the image resolutions differed. The higher frequency detectors provided better image resolution while the lower frequency detectors delineated the major structural traits with a higher signal-noise ratio. PMID:15128208

  3. Multiple Sclerosis: Pathogenesis and Treatment

    PubMed Central

    Loma, Ingrid; Heyman, Rock

    2011-01-01

    Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease of the central nervous system. It affects approximately 400,000 people in the United States and onset is usually during young adulthood. There are four clinical forms of MS, of which relapsing remitting type is the most common. As the etiology of MS is unknown, finding a cure will remain challenging. The main mechanism of injury appears to be inflammation and 8 agents are now FDA approved to help control MS. These agents for relapsing forms of MS target different parts of the immune system, with the end goal of decreasing and avoiding further inflammation. No agents are FDA approved for the primary progressive version of MS. FDA approved agents include four preparations of interferon ? (Avonex, Rebif, Betaseron and Extavia), glatiramer acetate (Copaxone), mitoxantrone (Novantrone), natalizumab (Tysabri) and fingolimod (Gilenya). There are several drug undergoing phase II and III trials. The heterogeneity of the MS disease process, individual patient response, and medication toxicities continue to challenge the treating physician. PMID:22379455

  4. Optical multiple access intersatellite links

    NASA Astrophysics Data System (ADS)

    Grant, M. A.; Matthews, N. F.; Robson, D.

    1988-03-01

    The feasibility of an optical implementation of a multiple access medium data rate data relay service on the timescale of Euro-DRS was assessed. The service requirements for the feasibility study are based on the service which, in existing or planned systems, is implemented at S band. The system should communicate simultaneously with up to 8 LEO users in orbits of radii up to 7400 km providing 8 independently agile links. On each link, it should communicate at up to 2Mb/sec, at bit error rates of 10 to the minus 6th power in the return direction (LEO to GEO). A design concept for the GEO central node was produced. Mass and power estimates were evaluated and a preliminary spacecraft accommodation study performed. The system weighs 130 kg and has a power consumption of 300 W. The optical subsystem occupies a 75 x 75 x 30 cm volume on the top floor of the spacecraft. A number of trade-offs were identified and performed in reaching the final system configuration. The system should have 1 telescope system per user, a periscope mirror configuration for coarse pointing, a single telescope for both transmit and receive, and the use of both 0.8 micron for the LEO-GEO link and 1.3 micron for GEO-LEO.

  5. MRI mimics of multiple sclerosis.

    PubMed

    Aliaga, Esther Sánchez; Barkhof, Frederik

    2014-01-01

    Diagnosis of multiple sclerosis (MS) is based on the demonstration of dissemination of lesions in space (DIS) and in time (DIT), as well as on the exclusion of an alternative neurologic disorder. As a paraclinical tool brain and/or spinal cord magnetic resonance imaging (MRI), showing typical lesion morphology, characteristic distribution of lesions, or involvement or specific anatomic structures, can support the diagnosis of MS. But from an imaging perspective a considerable amount of inherited and acquired disorders may manifest with radiologic evidence of DIT, DIS, or both. Hypoxic-ischemic vasculopathy, specially small-vessel disease, inflammatory disorders, vasculitis, and non-MS idiopathic inflammatory disorders, as well as some toxic, metabolic, and infectious disorders, may present mimicking MS on MR examinations and should be included in the differential diagnosis of MS-like lesions. Careful evaluation of associated findings on MRI, the so-called MRI red flags, such as the presence of infarcts, microbleeds, meningeal enhancement, and calcifications among others, are very helpful in suggesting a diagnosis other than MS. Complement MRI findings to patient's history, demographics, and serologic findings are crucial to achieve the correct diagnosis. We will review the most frequent radiologic appearance and differential features from the most frequent MS mimickers. PMID:24507523

  6. Review of optical multiple-input-multiple-output techniques in multimode fiber

    NASA Astrophysics Data System (ADS)

    Amphawan, Angela

    2011-10-01

    The success of optical multiple-input-multiple output (MIMO) systems in wireless communications has motivated interesting investigations of MIMO in optical fiber communications. This paper reviews various optical MIMO techniques in multimode fiber.

  7. Review of optical multiple-input-multiple-output techniques in multimode fiber

    Microsoft Academic Search

    Angela Amphawan

    2011-01-01

    The success of optical multiple-input-multiple output (MIMO) systems in wireless communications has motivated interesting investigations of MIMO in optical fiber communications. This paper reviews various optical MIMO techniques in multimode fiber.

  8. Code optimization and analysis for multiple-input and multiple-output communication systems 

    E-print Network

    Yue, Guosen

    2005-11-01

    Design and analysis of random-like codes for various multiple-input and multiple-output communication systems are addressed in this work. Random-like codes have drawn signi?cant interest because they o?er ...

  9. Taking a "Simple View" of the Dynamic Indicators of Basic Early Literacy Skills as a Predictor of Multiple Measures of Third-Grade Reading Comprehension

    ERIC Educational Resources Information Center

    Munger, Kristen A.; Blachman, Benita A.

    2013-01-01

    The purpose of this study was to examine the validity evidence of first-grade Dynamic Indicators of Basic Early Literacy Skills (DIBELS) scores for predicting third-grade reading comprehension scores. We used the "simple view" of reading as the theoretical foundation for examining the extent to which DIBELS subtest scores predict…

  10. A Best-Evidence Synthesis of the Relationship of Multiple Intelligence Instructional Approaches and Student Achievement Indicators in Secondary School Classrooms

    ERIC Educational Resources Information Center

    Hodge, Ethan Elliott

    2005-01-01

    The purpose of this study was to synthesize the literature in order to assess and quantify (if possible) the relationship between MI instructional approaches and student achievement indicators in secondary school classrooms (grades 6-12). This study employed the best-evidence synthesis methodology devised by Robert Slavin. Criteria for study…

  11. Switch and Deliver: Display layouts for MOMV (Multiple Operator Multiple Video feed) environments

    Microsoft Academic Search

    Talya Porat; Tal Oron-Gilad; Jacob Silbiger; Michal Rotem-Hovev

    2011-01-01

    ? Abstract—'Switch and Deliver' is a research project directed to design and develop tools\\/techniques and procedures to aid operators in handling Multiple Operator Multiple UAV (unmanned aerial vehicles) environments. It aims to identify what information and which tools and layouts will decrease switch- costs and improve overall mission performance. Nevertheless, most tools\\/techniques can be generalized to any Multiple Operator Multiple

  12. A novel flow multiplication attack against Tor

    Microsoft Academic Search

    Xiaogang Wang; Junzhou Luo; Ming Yang; Zhen Ling

    2009-01-01

    Tor has become one of the most popular overlay networks for anonymizing TCP traffic. A novel and effective flow multiplication attack against Tor is proposed in this paper, which exploits the fundamental vulnerability of anonymous Web browsing by using a man-in-the-middle attack on client's HTTP flow. In the flow multiplication attack, whenever a malicious exit onion router detects a Web

  13. Speaker adaptation using multiple reference speakers

    Microsoft Academic Search

    Francis Kubala; Richard Schwartz; Chris Barry

    1989-01-01

    We introduce a new technique for using the speech of multiple reference speakers as a basis for speaker adaptation in large vocabulary continuous speech recognition. In contrast to other methods that use a pooled reference model, this technique normalizes the training speech from multiple reference speakers to a single common feature space pooling it. The normalized and pooled speech can

  14. Folded layer multiple-pass cavity

    Microsoft Academic Search

    Yuguang Xu; Qinyue Yu; Bo Lyu; Shou-Hau Chen; Zhong-Hua Rong

    1991-01-01

    Structure of the folded layered multiple-pass cavity and its image quality are described, uniformity of scanning beam intensity at vertical direction in the middle position of the cavity is discussed, and the high precision result of the reflectance cavity mirror is given. The folded layered multiple-pass cavity presented in this article has the following physical requirements: it must have a

  15. A new method for multiple source location

    Microsoft Academic Search

    M. Coker; E. Ferrara

    1982-01-01

    The problem of bearing\\/emitter location estimation for multiple wideband sources is addressed. The approach is to extend a recent algebraic method originally derived for multiple narrowband signals. The extended method makes use of the concept of the approximate dimension of a signal space as defined by Slepian. Some properties of the proposed algorithm are explored, and example computer simulations are

  16. Application considerations for multiple battery disconnects

    Microsoft Academic Search

    Jim Giancaterino

    2000-01-01

    It is standard practice in telecommunication power systems to have multiple battery strings in parallel. Multiple strings allow power engineers to achieve higher ampere hour back up capacity as well as building in system redundancy by installing additional battery strings. In today's applications, we are seeing battery plants with greater than a dozen strings in parallel. Ease of growth and

  17. Learning Noisy Characters, Multiplication Codes, and

    E-print Network

    Goldwasser, Shafi

    Learning Noisy Characters, Multiplication Codes, and Cryptographic Hardcore Predicates by Adi, Multiplication Codes, and Cryptographic Hardcore Predicates by Adi Akavia Submitted to the Department is hardcore for a one-way function and apply it to a broad family of functions and predicates, showing new

  18. Multiple bit differential detection of offset QPSK

    NASA Technical Reports Server (NTRS)

    Simon, M.

    2003-01-01

    Analogous to multiple symbol differential detection of quadrature phase-shift-keying, a multiple bit differential detection scheme is described for offset QPSK that also exhibits continuous improvement in performance with increasing observation interval. Being derived from maximum-likelihood (ML) considerations, the proposed scheme is purported to be the most power efficient scheme for such a modulation and detection method.

  19. Constructive Multiple-Choice Testing System

    ERIC Educational Resources Information Center

    Park, Jooyong

    2010-01-01

    The newly developed computerized Constructive Multiple-choice Testing system is introduced. The system combines short answer (SA) and multiple-choice (MC) formats by asking examinees to respond to the same question twice, first in the SA format, and then in the MC format. This manipulation was employed to collect information about the two…

  20. Challenging Multiplicative Problems Can Elicit Sophisticated Strategies

    ERIC Educational Resources Information Center

    Downton, Ann

    2010-01-01

    This paper reports on 13 Grade 3 students' approaches to "Equivalent groups" and "Times" as "many" multiplicative word problems. The findings are part of a larger study relating to children's development of multiplicative thinking. Of particular interest was the extent to which task level of difficulty influenced students' strategy choice. The…