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1

Should "Multiple Imputations" Be Treated as "Multiple Indicators"?  

ERIC Educational Resources Information Center

Multiple imputations for latent variables are constructed so that analyses treating them as true variables have the correct expectations for population characteristics. Analyzing multiple imputations in accordance with their construction yields correct estimates of population characteristics, whereas analyzing them as multiple indicators generally…

Mislevy, Robert J.

1993-01-01

2

Multiplication  

NSDL National Science Digital Library

How sharp are your multiplication skills? Give these great math games a try ! Play Asteroids blaster and test your multiplication skills. How fast can you solve the problem... play a round of Baseball multiplication and see! Multiplication is fun and delicious with Crazy Cones. Help Lemonade Larry determine the correct amount! Test your multiplication skills with Tic Tac Toe! ...

Ms.roberts

2009-02-24

3

Estimating differential expression from multiple indicators  

PubMed Central

Regardless of the advent of high-throughput sequencing, microarrays remain central in current biomedical research. Conventional microarray analysis pipelines apply data reduction before the estimation of differential expression, which is likely to render the estimates susceptible to noise from signal summarization and reduce statistical power. We present a probe-level framework, which capitalizes on the high number of concurrent measurements to provide more robust differential expression estimates. The framework naturally extends to various experimental designs and target categories (e.g. transcripts, genes, genomic regions) as well as small sample sizes. Benchmarking in relation to popular microarray and RNA-sequencing data-analysis pipelines indicated high and stable performance on the Microarray Quality Control dataset and in a cell-culture model of hypoxia. Experimental-data-exhibiting long-range epigenetic silencing of gene expression was used to demonstrate the efficacy of detecting differential expression of genomic regions, a level of analysis not embraced by conventional workflows. Finally, we designed and conducted an experiment to identify hypothermia-responsive genes in terms of monotonic time-response. As a novel insight, hypothermia-dependent up-regulation of multiple genes of two major antioxidant pathways was identified and verified by quantitative real-time PCR.

Ilmjarv, Sten; Hundahl, Christian Ansgar; Reimets, Riin; Niitsoo, Margus; Kolde, Raivo; Vilo, Jaak; Vasar, Eero; Luuk, Hendrik

2014-01-01

4

Estimating differential expression from multiple indicators.  

PubMed

Regardless of the advent of high-throughput sequencing, microarrays remain central in current biomedical research. Conventional microarray analysis pipelines apply data reduction before the estimation of differential expression, which is likely to render the estimates susceptible to noise from signal summarization and reduce statistical power. We present a probe-level framework, which capitalizes on the high number of concurrent measurements to provide more robust differential expression estimates. The framework naturally extends to various experimental designs and target categories (e.g. transcripts, genes, genomic regions) as well as small sample sizes. Benchmarking in relation to popular microarray and RNA-sequencing data-analysis pipelines indicated high and stable performance on the Microarray Quality Control dataset and in a cell-culture model of hypoxia. Experimental-data-exhibiting long-range epigenetic silencing of gene expression was used to demonstrate the efficacy of detecting differential expression of genomic regions, a level of analysis not embraced by conventional workflows. Finally, we designed and conducted an experiment to identify hypothermia-responsive genes in terms of monotonic time-response. As a novel insight, hypothermia-dependent up-regulation of multiple genes of two major antioxidant pathways was identified and verified by quantitative real-time PCR. PMID:24586062

Ilmjärv, Sten; Hundahl, Christian Ansgar; Reimets, Riin; Niitsoo, Margus; Kolde, Raivo; Vilo, Jaak; Vasar, Eero; Luuk, Hendrik

2014-04-01

5

Monitoring Stream Channels and Riparian Vegetation--Multiple Indicators.  

National Technical Information Service (NTIS)

The purpose of Monitoring Stream Channels and Riparian Vegetation Multiple Indicators (or Multiple Indictor Method - MIM) is to provide an efficient and effective approach to monitoring streambanks, stream channels, and riparian vegetation. This protocol ...

E. R. Cowley S. J. Smith T. A. Burton

2007-01-01

6

Testing for Nonuniform Differential Item Functioning with Multiple Indicator Multiple Cause Models  

ERIC Educational Resources Information Center

In extant literature, multiple indicator multiple cause (MIMIC) models have been presented for identifying items that display uniform differential item functioning (DIF) only, not nonuniform DIF. This article addresses, for apparently the first time, the use of MIMIC models for testing both uniform and nonuniform DIF with categorical indicators. A…

Woods, Carol M.; Grimm, Kevin J.

2011-01-01

7

Multiple Indicators of High School Effectiveness.  

ERIC Educational Resources Information Center

Studies of school effectiveness have sometimes been criticized for placing too great an emphasis on a limited range of achievement measures as indicators of school quality. This paper draws on a study of secondary schools in Australia to explore the extent to which achievement growth, attitudes toward school, and school holding power are…

Ainley, John

8

A Multiple Indicators and Multiple Causes Model of Alternative Tobacco Use  

PubMed Central

Objective To examine the relationship between adolescents’ cigarette smoking experiences and alternative tobacco product (ATP) use. Methods Multiple indicators and multiple causes (MIMIC) models estimated simultaneously the relationship between cigarette smoking experiences and ATP use among high school students (N=1827) completing the 2009 Virginia Youth Tobacco Survey. Results Overall, ATP use was associated with adolescents’ ever use of cigarettes, early onset of cigarette smoking, cigarettes smoked per day, and peer smoking; however, important model differences between racial/ethnic groups were observed. Conclusions Prevention and cessation programs might reduce adolescent ATP use by targetting specific characterstics of cigarette smoking.

Nasim, Aashir; Blank, Melissa D.; Cobb, Caroline O.; Eissenberg, Thomas

2013-01-01

9

Superconformal indices for N=1 theories with multiple duals  

NASA Astrophysics Data System (ADS)

Following a recent work of Dolan and Osborn, we consider superconformal indices of four-dimensional N=1 supersymmetric field theories related by an electric-magnetic duality with the SP(2N) gauge group and fixed rank flavour groups. For the SP(2) (or SU(2)) case with 8 flavours, the electric theory has index described by an elliptic analogue of the Gauss hypergeometric function constructed earlier by the first author. Using the E-root system Weyl group transformations for this function, we build a number of dual magnetic theories. One of them was originally discovered by Seiberg, the second model was built by Intriligator and Pouliot, the third one was found by Csáki et al. We argue that there should be in total 72 theories dual to each other through the action of the coset group W(E)/S. For the general SP(2N), N>1, gauge group, a similar multiple duality takes place for slightly more complicated flavour symmetry groups. Superconformal indices of the corresponding theories coincide due to the Rains identity for a multidimensional elliptic hypergeometric integral associated with the BC-root system.

Spiridonov, V. P.; Vartanov, G. S.

2010-01-01

10

F-15 air navigation multiple indicator (ANMI) prototype development program  

NASA Astrophysics Data System (ADS)

The F-15 Air Navigation Multiple Indicator (ANMI) is the vertical situation display in the F-15A/B and C/D aircraft. The Air Force established the ANMI Prototype Development Program as a form, fit and function replacement for the existing Cathode Ray Tube (CRT) display. Oklahoma City Air Logistics Center (OC-ALC) is the lead agency for the development with financial support from the Producibility, Reliability and Maintainability (PRAM) Program Office at Wright-Patterson. SAIC was selected to design the prototype unit. Figure 1 is an exploded view of this prototype. The F-15 ANMI development required SAIC to address many new challenges. Four unique technical challenges were: (1) the development of a high resolution liquid crystal display (LCD), (2) the interface with an analog signal used to drive the existing CRT, (3) the development of a NTSC output, and (4) the sunlight readable, Night Vision Goggle compatible backlight. These technical aspects of the development are detailed in the body of this paper.

Buford, J.; George, S.; Altadonna, Lynn P.; Blowers, Dan

1995-06-01

11

Multiple uses of indicators and indices in cumulative effects assessment and management  

SciTech Connect

Both environmental indicators and multi-metric indices are useful for describing baseline conditions and qualitatively predicting the cumulative consequences of multiple actions. Several examples and case studies associated with indicators and/or indices are presented herein. They can be easily modified for usage in CEAM. Habitat suitability models reflect special indices related to habitat needs and quality for specific species or broad habitat types. Such models have been used to address direct and indirect effects, and with some modification, they can be also used to address cumulative effects of multiple actions. This review has indicated that there are numerous examples of such tools which have been or could be used in both EIA and CEAM. Some key lessons are: (1) in conducting CEAM studies, it is useful to think from the mindset that 'I am the VEC or indicator, and what is my historical and current condition and how have I, or will I, be affected by multiple past, present, and future actions?'; (2) due to the likely absence of detailed information on future actions, the described tools can still be used to 'predict' future conditions by focusing on qualitative up-or-down changes in individual indicators or indices with their aggregated displays; and (3) numerous regional and site-specific tools are currently available, with one example being indices of biological integrity for specific watersheds and water bodies. Such tools, even though they may not have been developed for CEAM usage, can certainly benefit CEAM studies and practice. Finally, usage of selected and appropriate tools as described herein can aid in conducting science-based, systematic, and documentable CEAM studies.

Canter, L.W., E-mail: envimptr@aol.com [University of Oklahoma and Environmental Impact Training, Horseshoe Bay, TX (United States); Atkinson, S.F. [Institute of Applied Science, University of North Texas, Denton, TX (United States)

2011-09-15

12

Iran's Multiple Indicator Demographic and Health Survey - 2010: Study Protocol  

PubMed Central

Background: There is an international emphasis on providing timely and high quality data to monitor progress of countries toward Millennium Development Goals. Iran's Multiple Indicator Demographic and Health Survey (IrMIDHS) aimed to provide valid information on population and health outcomes to monitor progress in achieving national priorities and health programs and to assist policy makers to design effective strategies for improving health outcomes and equity in access to care. Methods: A cross-sectional multi-stage stratified cluster-random survey is conducted through face-to-face household interviews. The sampling frame is developed using Iran's 2006 population and housing census. Provincial samples ranging are from a minimum of 400 households per province to 6400 households in Tehran province. Cluster size is 10 households. The target sample includes 3096 clusters: 2187 clusters in urban and 909 clusters in rural areas. IrMIDHS instruments include three questionnaires: Household questionnaire, women aged 15-54 questionnaire, children under five questionnaire, supervision and quality assessment checklists and data collection sheets and standard weight and height measurement tools for under-five children. A cascading decentralized training method is used for training data collection and supervision teams. Quality assurance procedures are defined for the five steps of conducting the survey including: Sampling, training data collection and training teams, survey implementation, data entry and analysis. A multi-layer supervision and monitoring procedure is established. All the questionnaires are double entered. Conclusions: IrMIDHS will provide valuable data for policymakers in Iran. Designing and implementation of the study involve contributions from academics as well as program managers and policy makers. The collaborative nature of the study may facilitate better usage of its results.

Rashidian, Arash; Karimi-Shahanjarini, Akram; Khosravi, Ardeshir; Elahi, Elham; Beheshtian, Maryam; Shakibazadeh, Elham; Khabiri, Roghayeh; Arab, Mohammad; Zakeri, Mohammad-Reza

2014-01-01

13

Multiple Sclerosis  

MedlinePLUS

MENU Return to Web version Multiple Sclerosis Overview What is multiple sclerosis (MS)? Multiple sclerosis is an autoimmune disease that affects the nervous system. Normally, antibodies produced by ...

14

International Development of the Patient-Reported Outcome Indices for Multiple Sclerosis (PRIMUS)  

Microsoft Academic Search

BackgroundThe Patient-Reported Indices for Multiple Sclerosis (PRIMUS) comprises a suite of three scales for assessing symptoms, activity limitations, and quality of life in multiple sclerosis (MS). It was developed in the UK and has been shown to have excellent psychometric properties. This study describes the adaptation of eight language versions for Canadian English, Canadian French, French, German, Italian, Spanish, Swedish,

Stephen P. McKenna; Lynda C. Doward; James Twiss; Peter Hagell; Nadia C. Oprandi; John Fisk; François Grand'Maison; Virender Bhan; Txomin Arbizu; David Brassat; Thomas Kohlmann; David M. Meads; Benjamin J. Eckert

2010-01-01

15

Convergent Evidence Scaling for Multiple Assessment Indicators: Conceptual Issues, Applications, and Technical Challenges  

ERIC Educational Resources Information Center

The purpose of this article is to present Convergent Evidence Scaling (CES) as an emergent method for combining data from multiple assessment indicators. The CES method combines single-case assessment data by converging data gathered across multiple persons, settings, or measures, thereby providing an overall criterion-referenced outcome on which…

Busse, R. T.; Elliott, Stephen N.; Kratochwill, Thomas R.

2010-01-01

16

An indicator of the multiple equilibria regime of the Atlantic meridional overturning circulation  

Microsoft Academic Search

Recent model results have suggested that there may be a scalar indicator ? monitoring whether the Atlantic meridional overturning circulation (MOC) is in a multiple equilibrium regime. The quantity ? is based on the net freshwater transport by the MOC into the Atlantic basin. It changes sign as soon as the steady Atlantic MOC enters the multiple equilibrium regime because

Selma E. Huisman; Matthijs den Toom; Henk A. Dijkstra; Sybren Drijfhout

2010-01-01

17

Multiplication Fun  

NSDL National Science Digital Library

Play to following games to pracitce your muliplicaiton tables. Hit a Home Run! Start with Multiplication Baseball (Easy). Once your have beat this team try to beat Multiplication Baseball (Medium). When you beat the first two teams try to beat this challanging team Multiplication Baseball (Hard) Learn your multiplication facts by playing Multiplication Flash Fun ...

Young, Mrs.

2007-10-25

18

Multiplication 2  

NSDL National Science Digital Library

Try some harder multiplication activities! Missing Factor Meteor Blasting Complete the Missing Step Batter s Up Multiplication Sum Sense Multiplication Challenge a Friend to Grand Prix Multiplication Double Digit Multiplication https://embed.espresso.co.uk/espresso/embed/images/logo_espresso.gif ) no-repeat center center"

Lerdahl, Miss

2010-11-16

19

Multiplication table  

NSDL National Science Digital Library

Help learn First learn go over your Learn The Multiplication table now get some extra help Learn The Multiplication table have fun Learn The multiplication table with games good luck practice test pre test pre test final test ...

Bgross

2011-04-14

20

Mastering Multiplication  

NSDL National Science Digital Library

Play the following games to practice your multiplication. Take a swing at Multplication Baseball! (Set with hard) Use your multiplication knowledge and defeat the Mayan Math Monster! (Set to hard) Quick! Stop the Multiplication Invader before it is too late! ...

Jackson, Ms.

2007-10-25

21

Control, compare and communicate: designing control charts to summarise efficiently data from multiple quality indicators  

PubMed Central

?? Summarising the complex data generated by multiple cross sectional quality indicators in a way that patients, clinicians, managers and policymakers find useful is challenging. A common approach is aggregation to create summary measures such as star ratings and balanced score cards, but these may conceal the detail needed to focus quality improvement. We propose an alternative way of summarising and presenting multiple quality indicators, suitable for use for quality improvement and governance. This paper discusses (1) control charts for repeated measurements of single processes as used in industrial statistical process control (SPC); (2) control charts for cross sectional comparison of many institutions for a single quality indicator (rarely used in industry but commonly proposed for health care); and (3) small multiple graphics which combine control chart signal extraction with efficient graphical presentations for multiple indicators.

Guthrie, B; Love, T; Fahey, T; Morris, A; Sullivan, F

2005-01-01

22

Multiplication Rocks!!!  

NSDL National Science Digital Library

Let's practice what we've learned about multiplication. Play at least one game in each of the categories. Times Table Practice: Design the Ultimate Fashion Outfit with Math Models Blast the Meteors before they destroy the ship in Meteor Multiplication More Multiplication: Batter's Up in Baseball Multiplication Win $1,000,000 in Who Wants To Be A Millionaire? ...

Peake, Mrs.

2009-04-15

23

Multiplication Mania!  

NSDL National Science Digital Library

These assignments will help you practice your multiplication facts. Work through these multiplication facts. Click on each link and scroll down past the red box to the orange box. Click on \\"Start Multiplication\\". After you type in your answer click on the \\"Check\\" box to check your answer. 1. Practice your multiplication facts 0-3. ...

Packard, Mrs.

2005-10-25

24

Multiplication Practice  

NSDL National Science Digital Library

Practice Your Multiplication Skills! Watch These Fun Multiplication Videos *Need a review? Watch the Multiplication is Repeated Addition Video Four Legged Zoo I ve Got 6 Ready or Not Here I Come (5s) Twelve Toes Elementary My Dear 2s Figure 8 Lucky 7s Video My Hero Zero Naughty Number 9 Practice your multiplication skills with these fun games: Multiplication Facts Become the king of multiplication with Castle Quest Dish up some ice cream with Crazy Cone Multiplication. Earn disco moves to make a dinosaur dance with Disco Dino. Design your own granny and make her race in a ...

Lerdahl, Miss

2010-02-23

25

Occupational stress and psychopathology in health professionals: an explorative study with the multiple indicators multiple causes (MIMIC) model approach.  

PubMed

Occupational stress is a multivariate process involving sources of pressure, psycho-physiological distress, locus of control, work dissatisfaction, depression, anxiety, mental health disorders, hopelessness, and suicide ideation. Healthcare professionals are known for higher rates of occupational-related distress (burnout and compassion fatigue) and higher rates of suicide. The purpose of this study was to explain the relationships between occupational stress and some psychopathological dimensions in a sample of health professionals. We investigated 156 nurses and physicians, 62 males and 94 females, who were administered self-report questionnaires to assess occupational stress [occupational stress inventory (OSI)], temperament (temperament evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire), and hopelessness (Beck hopelessness scale). The best Multiple Indicators Multiple Causes model with five OSI predictors yielded the following results: ?2(9) = 14.47 (p = 0.11); ?2/df = 1.60; comparative fit index = 0.99; root mean square error of approximation = 0.05. This model provided a good fit to the empirical data, showing a strong direct influence of casual variables such as work dissatisfaction, absence of type A behavior, and especially external locus of control, psychological and physiological distress on latent variable psychopathology. Occupational stress is in a complex relationship with temperament and hopelessness and also common among healthcare professionals. PMID:22632290

Iliceto, Paolo; Pompili, Maurizio; Spencer-Thomas, Sally; Ferracuti, Stefano; Erbuto, Denise; Lester, David; Candilera, Gabriella; Girardi, Paolo

2013-03-01

26

Parenting Multiples  

MedlinePLUS

... to take care of your babies. Back Continue Parenting Issues With Multiples It can be impossible to ... on it's apparent that their relationship is special. Parenting multiples has its challenges, but the rewards are ...

27

Multiplication Facts  

NSDL National Science Digital Library

You are going to play fun games to practice your multiplication facts. Help Larry figure out how much each person owes for his lemonade and work on your Multiplication Facts. Figure out the prices for 5 people. It\\'s multiplication, it\\'s bingo...no, its MATHO! Play two games of Matho and work on your multiplication. Are you a math Magician? Find out by playing two rounds of this game! Become a ...

Pocock, Mrs.

2006-10-26

28

How teams use indicators for quality improvement - a multiple-case study on the use of multiple indicators in multidisciplinary breast cancer teams.  

PubMed

A crucial issue in healthcare is how multidisciplinary teams can use indicators for quality improvement. Such teams have increasingly become the core component in both care delivery and in many quality improvement methods. This study aims to investigate the relationships between (1) team factors and the way multidisciplinary teams use indicators for quality improvement, and (2) both team and process factors and the intended results. An in-depth, multiple-case study was conducted in the Netherlands in 2008 involving four breast cancer teams using six structure, process and outcome indicators. The results indicated that the process of using indicators involves several stages and activities. Two teams applied a more intensive, active and interactive approach as they passed through these stages. These teams were perceived to have achieved good results through indicator use compared to the other two teams who applied a simple control approach. All teams experienced some difficulty in integrating the new formal control structure, i.e. measuring and managing performance, in their operational task, and in using their 'new' managerial task to decide as a team what and how to improve. Our findings indicate the presence of a network of relationships between team factors, the controllability and actionability of indicators, the indicator-use process, and the intended results. PMID:24034953

Gort, Marjan; Broekhuis, Manda; Regts, Gerdien

2013-11-01

29

Multiple Correlation versus Multiple Regression.  

ERIC Educational Resources Information Center

Describes differences between multiple correlation analysis (MCA) and multiple regression analysis (MRA), showing how these approaches involve different research questions and study designs, different inferential approaches, different analysis strategies, and different reported information. (SLD)

Huberty, Carl J.

2003-01-01

30

UNAIDS 'multiple sexual partners' core indicator: promoting sexual networks to reduce potential biases  

PubMed Central

UNAIDS proposed a set of core indicators for monitoring changes in the worldwide AIDS epidemic. This paper explores the validity and effectiveness of the ‘multiple sexual partners’ core indicator, which is only partially captured with current available data. The paper also suggests an innovative approach for collecting more informative data that can be used to provide an accurate measure of the UNAIDS’s ‘multiple sexual partners’ core indicator. Specifically, the paper addresses three major limitations associated with the indicator when it is measured with respondents’ sexual behaviors. First, the indicator assumes that a person’s risk of contracting HIV/AIDS/STIs is merely a function of his/her own sexual behavior. Second, the indicator does not account for a partner’s sexual history, which is very important in assessing an individual’s risk level. Finally, the 12-month period used to define a person’s risks can be misleading, especially because HIV/AIDS theoretically has a period of latency longer than a year. The paper concludes that, programmatically, improvements in data collection are a top priority for reducing the observed bias in the ‘multiple sexual partners’ core indicator.

Dimbuene, Zacharie Tsala; Emina, Jacques B.O.; Sankoh, Osman

2014-01-01

31

Multiplication Mania!  

NSDL National Science Digital Library

Fun games to practice your multiplication facts! Need a refreshing break? Come on over to the lemonade stand...Lemonade Stand At the beach, you can swim, sun, and practice your multiplication facts...Beach Multiplication How fast are you? Click here to...Race the Clock Do you have your spacesuit and astronaut food, are you ready for your...Mission to the Moon ...

Hoeman, Ms.

2008-09-18

32

[Multiple myeloma].  

PubMed

Multiple myeloma is the second most common hematological malignancy. It is defined by the presence of monoclonal plasma cells capable to produce a monoclonal paraprotein causing clinical abnormalities such as anemia, renal insufficiency, hypercalcemia, or bone lesions. New chromosomal or molecular abnormalities have been identified allowing a better management. Multiple myeloma is treatable and, although it remains incurable, the patient prognosis and quality of life has notably improved, so it is not rare to see series with a median survival longer than 5 years. Even more, it is possible by now to expect improvements respect to the standard autologous stem cell transplantation. This must be attributed to the emergence of a number of new therapies entering clinical practice over the last 6 years: thalidomide (Thalidomid Pharmion, Boulder, CO, USA), lenalidomide (Revlimid, Celgene Corporation, Summit, NJ, USA) and bortezomib (Velcade, Janssen Pharmaceutica N.V., Belgium). Finally, we also will review the current clinical experience in supportive therapy, which has also contributed to the patient outcome improvement with approaches such as: new indications for dialysis, use of erythropoietin receptor stimulating agents and bisphosphonates, and new surgical therapies such as vertebroplastia and kyphoplastia. PMID:17594862

García-Sanz, Ramón; Mateos, María Victoria; San Miguel, Jesús Fernando

2007-06-16

33

Multiple Sclerosis  

MedlinePLUS

Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the ... and your body, leading to the symptoms of MS. They can include Visual disturbances Muscle weakness Trouble ...

34

Multiple Sclerosis  

MedlinePLUS

Multiple sclerosis (MS) was first recognized as a disorder in the late nineteenth century, but only by the nineteen sixties did ... The first standard guidelines for the diagnosis of MS and a disability rating scale were also established ...

35

Multiplication Matho  

NSDL National Science Digital Library

This site has students practice their multiplication facts. They compete against the clock while picking the correct response from numerous choices. Student have Matho when they get five colored snakes in a row.

A + Math

2007-12-12

36

Multiple myeloma  

MedlinePLUS

Plasma cell dyscrasia; Plasma cell myeloma; Malignant plasmacytoma; Plasmacytoma of bone; Myeloma - multiple ... Elsevier Churchill-Livingstone; 2008:chap 110. Rajkumar SV. Plasma cell disorders. In: Goldman L, Schafer AI, eds. ...

37

Multiplication Mania  

NSDL National Science Digital Library

Brush up on your multiplication skills with these fun games. Math Magician Let\\'s see how you can work your math magic! Choose either multiplication or division on Level 1. Once you feel comfortable, move on to Level 2. Multiflyer Play this fun game while learning about space exploration. Batter s Up Baseball Take me out to the ball game! Practice your math facts with ...

Thompson, Mrs.

2006-04-01

38

[Multiple trichoepitheliomas].  

PubMed

We report on a 27-year-old male patient suffering from multiple trichoepitheliomas, which first appeared on his face at the age of 15 and later spread to his upper extremities and back. Multiple trichoepitheliomas are benign tumors of the skin appendages with autosomally dominant heredity. Clinically, these lesions have to be differentiated from other adnexal tumors, adenoma sebaceum, as well as basal cell nevus syndrome (Gorlin-Goltz's disease). PMID:2080659

Engelmann, L; Kunze, J

1990-11-01

39

Multiple Intelligences  

NSDL National Science Digital Library

Objective: To explore Howard Gardner\\'s Multiple Intelligences and apply what you have learned. Materials needed: Computer, Internet access, Word processor. Part 1: Learn who Howard Gardner is. Steps: 1. Go to the following site Howard Gardner Bio. 2. Read Howard Gardner\\'s bio. Part 2: Learn what the multiple intelligences are. Steps: 1. Visit Intelligences in a nut shell or the previous site. 2. Write, in a word processor, a brief description of the intelligences that Dr. ...

Jepsen, Mr.

2005-12-02

40

Therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress  

NASA Astrophysics Data System (ADS)

This quasi-experiment study examined the therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress. By utilizing drug interventions that reduced cardiovascular distress through changes in the hypertensive indices, previous studies have shown that improvements in life expectancy, lowering of health care costs in later years, and reduction in all-cause mortality were achieved. In fact, individuals without risk factors or with low risk factors for cardiovascular disease in young adulthood or middle age were healthier, had a greater life expectancy, and incurred lower health care costs in later years. The hypertensive indices of interest include elevated heart rate (HR), systolic blood pressure (Ps), diastolic blood pressure (PD), mean arterial blood pressure (MABP), pulse pressure (PP), and mechanical disadvantages of the heart MDH. Mechanical disadvantage of the heart is a term that has been developed for the purposes of this study. The alternative hypotheses for this study proposed to show a significant change in the relevant hypertensive indices of cardiovascular distress in volunteers after a minimum of 45 days treatment with multiple nutritional supplements. The target population was all middle-aged (30 to 65 years) volunteer hypertensives in Nigeria (West Africa), who were randomly assigned to either the experimental group or control group, controlling for individuals who were on any form of medication, smokers, alcoholics, and those who were pregnant or on contraceptives. Treatment involved multiple doses of the various vitamins, minerals, essential amino acids, essential fatty acids, and accessory nutrients in their complementary combinations that influence various levels of cardiovascular function. After 45 days of treatment, the differences between the mean sores of the experimental group and control group on Ps, PD, MABP, and PP were found to be statistically significant, at p ? .05 cut-off level for rejecting the null hypothesis for each dependent variable on a one-tailed student's t test. The same results were not demonstrated for HR and MDH. In summary, the therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress could provide a cost-effective, safe, healthy, and reliable way of preventing cardiovascular disease.

Okereke, Emmanuel O.

2000-09-01

41

Using Indicators of Multiple Deprivation to Demonstrate the Spatial Legacy of Apartheid in South Africa  

ERIC Educational Resources Information Center

This paper presents a spatial analysis of multiple deprivation in South Africa and demonstrates that the most deprived areas in the country are located in the rural former homeland areas. The analysis is undertaken using the datazone level South African Index of Multiple Deprivation which was constructed from the 2001 Census. Datazones are a new…

Noble, Michael; Wright, Gemma

2013-01-01

42

Assessing the Effects of Stimulation Versus Microswitch-Based Programmes on Indices of Happiness of Students with Multiple Disabilities  

ERIC Educational Resources Information Center

Background: Stimulation and microswitch-based programmes are considered main strategies to promote indices of happiness in students with multiple disabilities. However, only limited attempts have been made to assess the relative effects of the two programmes. This study conducted such an assessment with seven students with multiple disabilities.…

Lancioni, G. E.; Singh, N. N.; O'Reilly, M. F.; Oliva, D.; Smaldone, A.; Tota, A.; Martielli, G.; Stasolla, F.; Pontiggia, G.; Groeneweg, J.

2006-01-01

43

Comparison of the multiple-sample means with composite sample results for fecal indicator bacteria by quantitative PCR and culture.  

PubMed

Few studies have addressed the efficacy of composite sampling for measuring indicator bacteria by quantitative PCR (qPCR). We compared results from composited samples with multiple-sample means for culture- and qPCR-based water quality monitoring. Results from composited samples for both methods were similarly correlated to multiple-sample means and predicted criteria exceedances equally. PMID:22865067

Converse, Reagan R; Wymer, Larry J; Dufour, Alfred P; Wade, Timothy J

2012-10-01

44

A Hierarchical Bayesian Model for Reconstructing Multiple Streamflows and Climate Indices from Tree-ring or other paleo data  

Microsoft Academic Search

Reconstruction of annual or seasonal streamflow at multiple locations or of multiple climatic indices (e.g., PDSI at many locations, or ENSO, PDO, NAO) is sometimes of interest using an array of common paleo predictors. The predictands may be correlated with each other, and the form of each regression between predictand and predictors may also be very similar. Principal or Canonical

U. Lall; M. R. Zamora; E. Cook; A. Gelman; E. Sperry

2003-01-01

45

Multiplication Mania  

NSDL National Science Digital Library

Multiplication Mania is alive & well in 4A! With this online project, you can click on the links below & turn into a multiplication maniac no matter where you are.... Who Wants to Be a Mathionaire? See if you can earn enough money to call yourself a Mathionaire Millionaire! What facts do you need to practice? Choose here & improve your Superstars status! Do you want to practice x5? x2? x4? Choose your number & then Race Against Red to see how well you ...

Macumber, Ms.

2008-10-01

46

Discovering indices of contingency awareness in adults with multiple profound disabilities.  

PubMed

We conducted two studies to examine parameters of social attention in contingency awareness training using switch activation with individuals who had multiple profound disabilities. In Study 1 we compared leisure devices and social attention as reinforcing stimuli with 5 individuals. Results indicated the reinforcing qualities of social attention over leisure devices with 2 individuals and documented the importance of session length in training. In Study 2 we investigated idiosyncratic behaviors as indicators of responsiveness with 3 of the 5 original participants as they activated switches. Behavior changes during switch activation versus nonactivation times in the leisure device and social attention conditions suggested volitional movement supporting contingency awareness and preference. Implications for clinical practice are discussed. PMID:17559292

Saunders, Richard R; Saunders, Muriel D; Struve, Brittany; Munce, Abbie L; Olswang, Lesley B; Dowden, Patricia A; Klasner, Estelle R

2007-07-01

47

Multiple Pregnancy  

MedlinePLUS Videos and Cool Tools

... support groups (many of which can be found online) may provide a lifeline for the parents of multiples, who may feel isolated or depressed. Most physicians can provide appropriate referrals to a mental health professional or a support group. For more information, ...

48

Multiplication Frenzy  

NSDL National Science Digital Library

You are going to practice your multiplication facts!! Let\\'s travel to the moon! Moon Math!! (Just click on moon math when the page opens.) Time yourself! See how many you can get correct in one minute!! Shoot down the space crafts!! Math Invaders ...

Priola, Ms.

2008-07-12

49

Using Support Vector Machines with Multiple Indices of Diffusion for Automated Classification of Mild Cognitive Impairment  

PubMed Central

Few studies have looked at the potential of using diffusion tensor imaging (DTI) in conjunction with machine learning algorithms in order to automate the classification of healthy older subjects and subjects with mild cognitive impairment (MCI). Here we apply DTI to 40 healthy older subjects and 33 MCI subjects in order to derive values for multiple indices of diffusion within the white matter voxels of each subject. DTI measures were then used together with support vector machines (SVMs) to classify control and MCI subjects. Greater than 90% sensitivity and specificity was achieved using this method, demonstrating the potential of a joint DTI and SVM pipeline for fast, objective classification of healthy older and MCI subjects. Such tools may be useful for large scale drug trials in Alzheimer's disease where the early identification of subjects with MCI is critical.

O'Dwyer, Laurence; Lamberton, Franck; Bokde, Arun L. W.; Ewers, Michael; Faluyi, Yetunde O.; Tanner, Colby; Mazoyer, Bernard; O'Neill, Desmond; Bartley, Mairead; Collins, D. Ronan; Coughlan, Tara; Prvulovic, David; Hampel, Harald

2012-01-01

50

In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy  

PubMed Central

Background and Objective Visible – near infrared (optical) spectroscopy can be used to measure regional tissue hemodynamics and edema and, therefore, may represent an ideal tool with which to non-invasively study periodontal inflammation. The study objective was to evaluate the ability of optical spectroscopy to simultaneously determine multiple inflammatory indices (tissue oxygenation, total tissue hemoglobin, deoxyhemoglobin, oxygenated hemoglobin, and tissue edema) in periodontal tissues in vivo. Material and Methods Spectra were obtained, processed, and evaluated from healthy, gingivitis, and periodontitis sites (n = 133) using a portable optical – near infrared spectrometer. A modified Beer-Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of each inflammatory component to the overall spectrum. Results Optical spectroscopy was harnessed to successfully generate complex inflammatory profiles in periodontal tissues. Tissue oxygenation at periodontitis sites was significantly decreased (p<0.05) compared to gingivitis and healthy controls. This is largely due to an increase in deoxyhemoglobin in the periodontitis sites compared to healthy (p<0.01) and gingivitis (p=0.05) sites. Tissue water content per se showed no significant difference between the sites but a water index associated with tissue electrolyte levels and temperature differed was significantly between periodontitis sites when compared to both healthy and gingivitis sites (p<0.03). Conclusion This study establishes that optical spectroscopy can simultaneously determine multiple inflammatory indices directly in the periodontal tissues in vivo. Visible - near infrared spectroscopy has the potential to be developed into a simple, reagent-free, user friendly, chair-side, site-specific, diagnostic and prognostic test for periodontitis.

Liu, KZ; Xiang, XM; Man, A; Sowa, MG; Cholakis, N; Ghiabi, E; Singer, DL; Scott, DA

2008-01-01

51

Multiple Sclerosis  

Microsoft Academic Search

New therapies challenge the very definition of multiple sclerosis (MS). By classic definitions, MS is a chronic neurological\\u000a disease characterized by plaques or scars in the central nervous system (CNS) as a result of demyelization and atrophy of\\u000a neuronal axons. However, for most diagnosed with MS, symptoms and progression are much more heterogeneous than that definition\\u000a would imply. For most

M. Patricia Leuschen; Kathleen M. Healey; Mary L. Filipi

52

Multiple myeloma.  

PubMed

Essential facts Multiple myeloma is a form of cancer arising from plasma cells made in the bone marrow. The middle or lower back, rib cage and hips are the most common sites. Around 4,800 people in the UK are diagnosed each year and it is a complex and incurable disease. However, thanks to new treatments in the past ten years, survival rates are improving at a faster rate than for any other cancer in the UK. PMID:24866646

2014-05-28

53

Multiple sclerosis  

PubMed Central

Introduction Multiple sclerosis is the most common cause of neurological disability in young adults. Irreversible disability can occur, but life expectancy is generally not affected. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions aimed at reducing relapse rates and disability in people with multiple sclerosis? What are the effects of interventions to improve symptoms during acute relapse? What are the effects of treatments for fatigue, spasticity, and multidisciplinary care on disability in people with multiple sclerosis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2008 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 68 systematic reviews, RCTs, and observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions In this systematic review, we present information relating to the effectiveness and safety of the following key interventions: amantadine, azathioprine, behaviour modification, botulinum toxin, corticosteroids, exercise, gabapentin, inpatient or outpatient rehabilitation, interferon beta, intrathecal baclofen, intravenous immunoglobulin, methotrexate, mitoxantrone, modafinil, natalizumab, oral drug treatments, parenteral glatiramer acetate, physiotherapy, and plasma exchange.

2009-01-01

54

Large-scale diversity of slope fishes: pattern inconsistency between multiple diversity indices.  

PubMed

Large-scale studies focused on the diversity of continental slope ecosystems are still rare, usually restricted to a limited number of diversity indices and mainly based on the empirical comparison of heterogeneous local data sets. In contrast, we investigate large-scale fish diversity on the basis of multiple diversity indices and using 1454 standardized trawl hauls collected throughout the upper and middle slope of the whole northern Mediterranean Sea (36°3'- 45°7' N; 5°3'W - 28°E). We have analyzed (1) the empirical relationships between a set of 11 diversity indices in order to assess their degree of complementarity/redundancy and (2) the consistency of spatial patterns exhibited by each of the complementary groups of indices. Regarding species richness, our results contrasted both the traditional view based on the hump-shaped theory for bathymetric pattern and the commonly-admitted hypothesis of a large-scale decreasing trend correlated with a similar gradient of primary production in the Mediterranean Sea. More generally, we found that the components of slope fish diversity we analyzed did not always show a consistent pattern of distribution according either to depth or to spatial areas, suggesting that they are not driven by the same factors. These results, which stress the need to extend the number of indices traditionally considered in diversity monitoring networks, could provide a basis for rethinking not only the methodological approach used in monitoring systems, but also the definition of priority zones for protection. Finally, our results call into question the feasibility of properly investigating large-scale diversity patterns using a widespread approach in ecology, which is based on the compilation of pre-existing heterogeneous and disparate data sets, in particular when focusing on indices that are very sensitive to sampling design standardization, such as species richness. PMID:23843962

Gaertner, Jean-Claude; Maiorano, Porza; Mérigot, Bastien; Colloca, Francesco; Politou, Chrissi-Yianna; Gil De Sola, Luis; Bertrand, Jacques A; Murenu, Matteo; Durbec, Jean-Pierre; Kallianiotis, Argyris; Mannini, Alessandro

2013-01-01

55

MULTIPLE TIDAL DISRUPTIONS AS AN INDICATOR OF BINARY SUPERMASSIVE BLACK HOLE SYSTEMS  

SciTech Connect

We find that the majority of systems hosting multiple tidal disruptions (TDs) are likely to contain hard binary supermassive black hole (SMBH) systems, and also show that the rates of these repeated events are high enough to be detected by the Large Synoptic Survey Telescope (LSST) over its lifetime. Therefore, these multiple TD events provide a novel method for identifying SMBH binary systems with parsec to subparsec separations. The rates of TDs are investigated using simulations of non-interacting stars initially orbiting a primary SMBH and the potential of the model stellar cusp. The stars are then evolved forward in time and perturbed by a secondary SMBH inspiraling from the edge of the cusp to its stalling radius. We find with conservative magnitude estimates that the next-generation transient survey LSST should detect multiple TDs in approximately three galaxies over five years of observation, though less conservative estimates could increase this rate by an order of magnitude.

Wegg, Christopher; Nate Bode, J., E-mail: wegg@tapir.caltech.edu [Theoretical Astrophysics, California Institute of Technology, MC 350-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States)

2011-09-01

56

Multiple indications for everolimus after liver transplantation in current clinical practice  

PubMed Central

AIM: To assess our experience with the use and management of everolimus-based regimens post-liver transplantation and to redefine the potential role of this drug in current clinical practice. METHODS: From October 1988 to December 2012, 1023 liver transplantations were performed in 955 patients in our Unit. Seventy-four patients (7.74%) received immunosuppression with everolimus at some time post-transplantation. Demographic characteristics, everolimus indication, time elapsed from transplantation to the introduction of everolimus, doses and levels administered, efficacy, side effects, discontinuation and post-conversion survival were analyzed. RESULTS: Mean age at the time of conversion to everolimus was 57.7 ± 10 years. Indications for conversion were: refractory rejection 31.1%, extended hepatocellular carcinoma in explanted liver 19%, post-transplant hepatocellular carcinoma recurrence 8.1%, de novo tumour 17.6%, renal insufficiency 8.1%, severe neurotoxicity 10.8%, and others 5.4%. Median time from transplantation to introduction of everolimus was 6 mo (range: 0.10-192). Mean follow-up post-conversion was 22 ± 19 mo (range: 0.50-74). The event for which the drug was indicated was resolved in 60.8% of patients, with the best results in cases of refractory rejection, renal insufficiency and neurotoxicity. Results in patients with cancer were similar to those of a historical cohort treated with other immunosuppressants. The main side effects were dyslipidemia and infections. Post-conversion acute rejection occurred in 14.9% of cases. The drug was discontinued in 28.4% of patients. CONCLUSION: Everolimus at low doses in combination with tacrolimus is a safe immunosuppressant with multiple early and late indications post-liver transplantation.

Bilbao, Itxarone; Dopazo, Cristina; Lazaro, Jose; Castells, Lluis; Caralt, Mireia; Sapisochin, Gonzalo; Charco, Ramon

2014-01-01

57

Economic Adversity and Children's Sleep Problems: Multiple Indicators and Moderation of Effects  

PubMed Central

Objective Toward explicating relations between economic adversity and children’s sleep, we examined associations between multiple indicators of socioeconomic status (SES)/adversity and children’s objectively and subjectively derived sleep parameters; ethnicity was examined as potential moderator. Methods Participants were 276 third- and fourth-grade children and their families (133 girls; M age = 9.44 years; SD = .71): 66% European American (EA) and 34% African American (AA). Four SES indicators were used: income-to-needs ratio, perceived economic well-being, maternal education, and community poverty. Children wore actigraphs for 7 nights and completed a self-report measure to assess sleep problems. Results Objectively and subjectively assessed sleep parameters were related to different SES indicators, and overall worse sleep was evident for children from lower SES homes. Specifically, children from homes with lower income-to-needs ratios had higher levels of reported sleep/wake problems. Parental perceived economic well-being was associated with shorter sleep minutes and greater variability in sleep onset for children. Lower mother’s education was associated with lower sleep efficiency. Children who attended Title 1 schools had shorter sleep minutes. Ethnicity was a significant moderator of effects in the link between some SES indicators and children’s sleep. AA children’s sleep was more negatively affected by income-to-needs ratio and mother’s education than was the sleep of EA children. Conclusions The results advocate for the importance of specifying particular SES and sleep variables used because they may affect the ability to detect associations between sleep and economic adversity.

El-Sheikh, Mona; Bagley, Erika J.; Keiley, Margaret; Elmore-Staton, Lori; Chen, Edith; Buckhalt, Joseph A.

2014-01-01

58

Multiple sclerosis  

PubMed Central

Multiple sclerosis (MS) is a multifocal demyelinating disease with progressive neurodegeneration caused by an autoimmune response to self-antigens in a genetically susceptible individual. While the formation and persistence of meningeal lymphoid follicles suggest persistence of antigens to drive the continuing inflammatory and humoral response, the identity of an antigen or infectious agent leading to the oligoclonal expansion of B and T cells is unknown. In this review we examine new paradigms for understanding the immunopathology of MS, present recent data defining the common genetic variants underlying disease susceptibility, and explore how improved understanding of immune pathway disruption can inform MS prognosis and treatment decisions.

Nylander, Alyssa; Hafler, David A.

2012-01-01

59

Multiple sclerosis  

PubMed Central

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.

Hafler, David A.

2004-01-01

60

Multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system. Common manifestations include paresthesias, diplopia, loss of vision, numbness or weakness of the limbs, bowel or bladder dysfunction, spasticity, ataxia, fatigue, and mental changes. Four main patterns of MS are recognized: relapsing remitting, primary progressive, secondary progressive, and progressive relapsing. The cause of MS is unknown, although it appears to be an autoimmune disease. Much of what is known about MS has been learned from an animal model of the disease, experimental allergic encephalomyelitis. PMID:24381825

Gaby, Alan

2013-01-01

61

A study of multiple deliveries in Portugal: indications of an Iberian Peninsula pattern.  

PubMed

Information on multiple deliveries with regard to Portugal is scarce. Based on data provided by the Portuguese Institute of Statistics (INE), the rates for double and triple deliveries were calculated since 1930. The results obtained show for twins a uniform temporal pattern up to the 1970s. At this time rates decreased, but later they gradually recovered, reaching their maximum level in 2010. For triplets, the highest rates occurred between 1999 and 2002. For the period 1988-2011, the rates of multiple deliveries were related to a set of variables recorded in the INE database on live births. Significant differences (p < .001) between simple and multiple deliveries were obtained for maternal age, parity and marital status. Considering the year when the delivery occurred, significant differences (p < .001) persisted for maternal age regardless of the year. For the type of mating, significance was consistently found since the year 2002 (either by using the marital or the cohabitation criteria), and for parity since 2003. With regard to territorial variation, throughout seven periods between 1930 and 2011, the rates among the 20 administrative Portuguese territories, including the two insular districts of Açores and Madeira, were mostly stable for twinning rates, with a minimum level in 1970-1989. Regarding triplets, the greatest inter-district variation was found after 1980. The results of the Portuguese study on multiple deliveries are interpreted in the context of the Iberian Peninsula based on findings reported for Spain. PMID:23941679

Fuster, Vicente; Santos, Carlota; Román-Busto, Jorge; Magalhaes, Manuel

2013-10-01

62

Evidence of contingency awareness in people with profound multiple impairments: response duration versus response rate indicators  

Microsoft Academic Search

Evidence of contingency awareness in people with profound multiple impairments is often elusive due to numerous variables that impede learning and contribute to performance variability. Recent research has shown that measuring duration of responding rather than rate has promise for more accurate inferences. Duration measures of adaptive-switch use were obtained with 50 participants during empirical tests for contingency awareness. Nearly

Muriel D Saunders; Geralyn R Timler; Timothy B Cullinan; Shirley Pilkey; Kent A Questad; Richard R Saunders

2003-01-01

63

Adolescent Non-Involvement in Multiple Risk Behaviors: An Indicator of Successful Development?  

ERIC Educational Resources Information Center

Based on the conceptualization of successful development as the joint maximization of desirable outcomes and minimization of undesirable outcomes (Baltes, 1997), the present study examined connections between adolescent non-involvement in multiple risk behaviors and positive developmental status. Results from a survey of 7290 high school students…

Willoughby, Teena; Chalmers, Heather; Busseri, Michael A.; Bosacki, Sandra; Dupont, Diane; Marini, Zopito; Rose-Krasnor, Linda; Sadava, Stan; Ward, Anthony; Woloshyn, Vera

2007-01-01

64

Multiple myeloma.  

PubMed

Multiple myeloma (MM) constitutes 1% of malignant diseases and 15% of haematological malignancies. In virtually all patients MM is preceded by monoclonal gammopathy of undetermined significance (MGUS). The cause of monoclonal gammopathies and the mechanisms of progression are unknown. The diagnosis of MM requires the presence of an M-protein in serum and/or urine, increased bone marrow plasma cells and related organ or tissue impairment. Cytogenetic status, serum ?2-microglobulin and response to therapy are the key prognostic factors. The treatment of younger patients with MM should include a triple-agent induction regimen (i.e. bortezomib/thalidomide/dexamethasone), autologous stem cell transplantation (ASCT) and consolidation and maintenance incorporating novel agents along with sequential minimal residual disease studies to determine for how long treatment is still of benefit. Allogeneic transplantation with reduced-intensity conditioning is promising but remains experimental. For patients not eligible for ASCT the best initial regimens are melphalan/prednisone/thalidomide (MPT), melphalan/prednisone/bortezomib (MPV) and lenalidomide/dexamethasone. In relapsing patients, the choice of salvage therapy should depend on: (i) the components of initial therapy, (ii) the degree and duration of response, (iii) type of relapse: aggressive versus indolent, (iv) previous toxicities and (v) age and performance status. A sequential approach is preferred over combination of multiple agents. Supportive measures include the use of bisphosphonates and erythropoietin according to the updated guidelines. PMID:20943635

Bladé, J; Cibeira, M Teresa; Fernández de Larrea, C; Rosiñol, L

2010-10-01

65

Multiple sclerosis.  

PubMed

Multiple sclerosis is the prototype inflammatory autoimmune disorder of the central nervous system and, with a lifetime risk of one in 400, potentially the most common cause of neurological disability in young adults. As with all complex traits, the disorder results from an interplay between as yet unidentified environmental factors and susceptibility genes. Together, these factors trigger a cascade of events, involving engagement of the immune system, acute inflammatory injury of axons and glia, recovery of function and structural repair, post-inflammatory gliosis, and neurodegeneration. The sequential involvement of these processes underlies the clinical course characterised by episodes with recovery, episodes leaving persistent deficits, and secondary progression. The aim of treatment is to reduce the frequency, and limit the lasting effects, of relapses, relieve symptoms, prevent disability arising from disease progression, and promote tissue repair. Despite limited success in each of these categories, everyone touched by multiple sclerosis looks for a better dividend from applying an improved understanding of the pathogenesis to clinical management. PMID:11955556

Compston, Alastair; Coles, Alasdair

2002-04-01

66

Information processing and magnetic resonance imaging indices of brain pathology in multiple sclerosis.  

PubMed

Accumulation of central nervous system (CNS) pathology affects cognitive processing speed and efficiency and is thought to underlie attentional and executive deficits in multiple sclerosis (MS). Most clinical neuropsychological tests are multifactorial and are limited in their sensitivity to specific cognitive processes. This may, in part, account for the low to moderate correlations between clinical test results and magnetic resonance imaging (MRI) indices of brain pathology. We compared the ability of a clinical and an experimental test of cognitive processing speed to differentiate domain-specific cognitive changes in MS, and examined relations between test performance and MRI measures of brain pathology. Twelve MS patients and 12 controls completed the Paced Auditory Serial Addition Test (PASAT) and the Attention Networks Test-Interactions (ANT-I), a computerized response latency task. Subjects also had MRI scans that included T1, T2, and fluid-attenuated inversion recovery (FLAIR) sequences that provided global and localized volumetric measures. Patients made more errors on the PASAT and were slower on the ANT-I. The ANT-I also revealed specific deficits in response inhibition. In addition, ANT-I performance was associated with changes in a number of MRI measures, which was not the case for the PASAT. Reaction time paradigms that manipulate within-task demands on distinct cognitive functions may provide meaningful markers of brain disease burden in MS. PMID:24453738

Omisade, Antonina; Fisk, John D; Klein, Raymond M; Schmidt, Matthias; Darvesh, Sultan; Bhan, Virender

2012-01-01

67

Information Processing and Magnetic Resonance Imaging Indices of Brain Pathology in Multiple Sclerosis  

PubMed Central

Accumulation of central nervous system (CNS) pathology affects cognitive processing speed and efficiency and is thought to underlie attentional and executive deficits in multiple sclerosis (MS). Most clinical neuropsychological tests are multifactorial and are limited in their sensitivity to specific cognitive processes. This may, in part, account for the low to moderate correlations between clinical test results and magnetic resonance imaging (MRI) indices of brain pathology. We compared the ability of a clinical and an experimental test of cognitive processing speed to differentiate domain-specific cognitive changes in MS, and examined relations between test performance and MRI measures of brain pathology. Twelve MS patients and 12 controls completed the Paced Auditory Serial Addition Test (PASAT) and the Attention Networks Test–Interactions (ANT-I), a computerized response latency task. Subjects also had MRI scans that included T1, T2, and fluid-attenuated inversion recovery (FLAIR) sequences that provided global and localized volumetric measures. Patients made more errors on the PASAT and were slower on the ANT-I. The ANT-I also revealed specific deficits in response inhibition. In addition, ANT-I performance was associated with changes in a number of MRI measures, which was not the case for the PASAT. Reaction time paradigms that manipulate within-task demands on distinct cognitive functions may provide meaningful markers of brain disease burden in MS.

Fisk, John D.; Klein, Raymond M.; Schmidt, Matthias; Darvesh, Sultan; Bhan, Virender

2012-01-01

68

Measurement of metabolic extraction of tracers in the lung using a multiple indicator dilution technique. [Dogs  

SciTech Connect

Selective pulmonary uptake of many natural and synthetic substances has been demonstrated by physiologists and pharmacologists using isolated perfused lung preparations or invasive techniques. It is difficult, however, to relate these laboratory studies to disease processes and to the study of problems encountered in a clinical environment. Our goal was to develop a noninvasive method for studying the pulmonary uptake of tracer substances using available radiotracers, gamma cameras, and computers that would give information similar, if not identical, to that from the invasive laboratory methods, and that could be applied in a clinical setting. The multiple-indicator dilution technique, modified for external counting, is well suited for such studies of pulmonary uptake of tracer substances. In this study, Tc-99m micro sulfur colloid (Tc-99m micro SC) was used as an intravascular reference tracer, N-isopropyl-p-(/sup 123/I)iodoamphetamine (I-123 IMP) as a cellular test tracer amine, and In-111 DTPA as an extracellular tracer. Calculated first-pass lung uptakes of I-123 IMP and In-111 DTPA were 0.92 +/- 0.04 and 0.17 +/- 0.04, respectively, relative to the reference tracer. Using this approach, the first-pass pulmonary extraction of a variety of radiolabeled test tracers can be measured in a clinical environment in a variety of physiologic settings.

Rahimian, J.; Glass, E.C.; Touya, J.J.; Akber, S.F.; Graham, L.S.; Bennett, L.R.

1984-01-01

69

The Receiver Operational Characteristic for Binary Classification with Multiple Indices and Its Application to the Neuroimaging Study of Alzheimer's Disease  

PubMed Central

Given a single index, the receiver operational characteristic (ROC) curve analysis is routinely utilized for characterizing performances in distinguishing two conditions/groups in terms of sensitivity and specificity. Given the availability of multiple data sources (referred to as multi-indices), such as multimodal neuroimaging data sets, cognitive tests, and clinical ratings and genomic data in Alzheimer’s disease (AD) studies, the single-index-based ROC underutilizes all available information. For a long time, a number of algorithmic/analytic approaches combining multiple indices have been widely used to simultaneously incorporate multiple sources. In this study, we propose an alternative for combining multiple indices using logical operations, such as “AND,” “OR,” and “at least n” (where n is an integer), to construct multivariate ROC (multiV-ROC) and characterize the sensitivity and specificity statistically associated with the use of multiple indices. With and without the “leave-one-out” cross-validation, we used two data sets from AD studies to showcase the potentially increased sensitivity/specificity of the multiV-ROC in comparison to the single-index ROC and linear discriminant analysis (an analytic way of combining multi-indices). We conclude that, for the data sets we investigated, the proposed multiV-ROC approach is capable of providing a natural and practical alternative with improved classification accuracy as compared to univariate ROC and linear discriminant analysis.

Wu, Xia; Li, Juan; Ayutyanont, Napatkamon; Protas, Hillary; Jagust, William; Fleisher, Adam; Reiman, Eric; Yao, Li; Chen, Kewei

2014-01-01

70

[Multiple myeloma].  

PubMed

Multiple myeloma (MM) is a cancer originating from terminally differentiated B lymphocytes, the plasma cells and is classified as a B cell non-Hodgkin lymphoma. As clonal plasma cells secrete immunoglobulin molecules (lacking antigenic specificity), an "M component" can incidentally be detected. Besides intact immunoglobulin molecules, free light chains can be produced. Although there is no specific treatment for monoclonal gammopathy of undetermined significance (MGUS), which is the defined as the presence of clonal bone marrow plasma cells and low levels (serum and/or urine) of the M component, it should be followed up in affected individuals. The symptoms of MM are numerous and often nonspecific. Diagnosis includes the quantification of monoclonal proteins in serum and urine, blood count, electrolytes and renal function, imaging of the skeleton and bone marrow puncture. The cornerstone of therapy includes melphalan- or cyclophosphamide-based regimens incorporating one of the "novel drugs" (i.e. bortezomib, thalidomide, or lenalidomide). PMID:23860514

Kortüm, K M; Engelhardt, M; Rasche, L; Knop, S; Einsele, H

2013-08-01

71

Multiple myeloma.  

PubMed Central

Multiple myeloma occurs in over 2000 new patients in England and Wales each year. It presents most frequently as bone pain and patients tend to become dehydrated and may develop renal failure. No available treatment is curative, but about two thirds of patients achieve a stable response with low dose combination chemotherapy. Combination chemotherapy including doxorubicin and carmustine with the alkylating agents cyclophosphamide and melphalan achieve a higher stable response rate than conventional treatment with melphalan and prednisone without additional haematological toxicity. These responses are associated with loss of bone pain and patients remain symptom free for months without further treatment. Relapse occurs on average in a little under two years and, though second responses are frequently obtained, the disease eventually becomes refractory. This paper looks at who should be treated and the benefits that may be expected from the treatments available.

MacLennan, I. C.; Drayson, M.; Dunn, J.

1994-01-01

72

Genetic diversity and population structure of Lantana camara in India indicates multiple introductions and gene flow.  

PubMed

Lantana camara is a highly invasive plant, which has spread over 60 countries and island groups of Asia, Africa and Australia. In India, it was introduced in the early nineteenth century, since when it has expanded and gradually established itself in almost every available ecosystem. We investigated the genetic diversity and population structure of this plant in India in order to understand its introduction, subsequent range expansion and gene flow. A total of 179 individuals were sequenced at three chloroplast loci and 218 individuals were genotyped for six nuclear microsatellites. Both chloroplasts (nine haplotypes) and microsatellites (83 alleles) showed high genetic diversity. Besides, each type of marker confirmed the presence of private polymorphism. We uncovered low to medium population structure in both markers, and found a faint signal of isolation by distance with microsatellites. Bayesian clustering analyses revealed multiple divergent genetic clusters. Taken together, these findings (i.e. high genetic diversity with private alleles and multiple genetic clusters) suggest that Lantana was introduced multiple times and gradually underwent spatial expansion with recurrent gene flow. PMID:24119091

Ray, A; Quader, S

2014-05-01

73

Modeling Multiplication with Fractions  

NSDL National Science Digital Library

Students will relate multiplication strategies with fractions through problem solving situations. This lesson connects prior understanding of multiplication and equal groups to multiplication of fractions.

Ratasky, Joseph

2012-08-18

74

Multiple myeloma  

PubMed Central

Summary Multiple myeloma accounts for 10% of all hematologic cancers. Median age at diagnosis is 69 years for men and 72 years for women. The incidence of MM has remained relatively stable, but the associated mortality has declined since the early 1990s. The knowledge acquired about the bone marrow microenvironment in MM and the availability of new drugs has significantly improved patients survival in the past 10 years. Immunomodulatory drugs (thalidomide, lenalidomide) and proteasome inhibitors (bortezomib, carfilzomib) can induce apoptosis of myeloma plasma cells and suppress cytokine release and metabolic ways which sustain the disease. These novel agents demonstrate substantial activity either alone or as part of a range of combination regimens. MM therapy is now based on 1 or 2 new drugs plus standard chemotherapy. Induction is patient tailored and first of all it depends on eligibility for stem-cell transplantation and key presenting features of the patients and the disease. Noteworthy, novel agent-based combination therapies may overcome most of poor prognostic factors. Up to 80% of newly diagnosed MM patients present with osteopenia, osteolysis and fractures. Thalidomide, lenalidomide and bortezomib have a beneficial effect on myeloma-related bone disease. Thalidomide reduces bone resorption, lenalidomide and bortezomib inhibit osteoclast growth and survival, and specifically target key factors in osteoclastogenesis, preventing development of osteolytic lesions. Noteworthy, new therapies offer higher complete response rates than previously reported with standard regimens.

Ciolli, Stefania

2012-01-01

75

Using Multiple Calibration Indices in Order to Capture the Complex Picture of What Affects Students' Accuracy of Feeling of Confidence  

ERIC Educational Resources Information Center

The present study used multiple calibration indices to capture the complex picture of fifth graders' calibration of feeling of confidence in mathematics. Specifically, the effects of gender, type of mathematical problem, instruction method, and time of measurement (before and after problem solving) on calibration skills were investigated. Fourteen…

Boekaerts, Monique; Rozendaal, Jeroen S.

2010-01-01

76

Measurement with multiple indicators and psychophysical scaling in the context of Fishbein and Ajzen's theory of reasoned action  

Microsoft Academic Search

Two experiments were carried out to test the theory of reasoned action of Fishbein and Ajzen. The measurements were done using two category scales and two psychophysical scales. No consistent difference in results was found between the four modalities. However, if the latter were used as multiple indicators for the model components in a latent variables model, the parameter values

Bas Van Den Putte; Willem E. Saris; Johan Hoogstraten

1995-01-01

77

Multiple osteochondromas  

PubMed Central

Multiple osteochondromas (MO) is characterised by development of two or more cartilage capped bony outgrowths (osteochondromas) of the long bones. The prevalence is estimated at 1:50,000, and it seems to be higher in males (male-to-female ratio 1.5:1). Osteochondromas develop and increase in size in the first decade of life, ceasing to grow when the growth plates close at puberty. They are pedunculated or sessile (broad base) and can vary widely in size. The number of osteochondromas may vary significantly within and between families, the mean number of locations is 15–18. The majority are asymptomatic and located in bones that develop from cartilage, especially the long bones of the extremities, predominantly around the knee. The facial bones are not affected. Osteochondromas may cause pain, functional problems and deformities, especially of the forearm, that may be reason for surgical removal. The most important complication is malignant transformation of osteochondroma towards secondary peripheral chondrosarcoma, which is estimated to occur in 0.5–5%. MO is an autosomal dominant disorder and is genetically heterogeneous. In almost 90% of MO patients germline mutations in the tumour suppressor genes EXT1 or EXT2 are found. The EXT genes encode glycosyltransferases, catalyzing heparan sulphate polymerization. The diagnosis is based on radiological and clinical documentation, supplemented with, if available, histological evaluation of osteochondromas. If the exact mutation is known antenatal diagnosis is technically possible. MO should be distinguished from metachondromatosis, dysplasia epiphysealis hemimelica and Ollier disease. Osteochondromas are benign lesions and do not affect life expectancy. Management includes removal of osteochondromas when they give complaints. Removed osteochondromas should be examined for malignant transformation towards secondary peripheral chondrosarcoma. Patients should be well instructed and regular follow-up for early detection of malignancy seems justified. For secondary peripheral chondrosarcoma, en-bloc resection of the lesion and its pseudocapsule with tumour-free margins, preferably in a bone tumour referral centre, should be performed.

Bovee, Judith VMG

2008-01-01

78

Asset life prediction using multiple degradation indicators and lifetime data: A gamma-based state space model approach  

Microsoft Academic Search

This paper proposes a Gamma-based state space model to predict engineering asset life when multiple degradation indicators are involved and the failure threshold on these indicators are uncertain. Monte Carlo-based parameter estimation and model inference algorithms are developed to deal with the proposed Gamma-based state space model. A case study using real data from industry is conducted to compare the

Yifan Zhou; Lin Ma; Joseph Mathew; Hack-Eun Kim; Rodney Wolff

2009-01-01

79

Increased serum levels of soluble CD14 indicate stable multiple sclerosis.  

PubMed

The aim of this study was to evaluate a possible role of soluble CD14 (sCD14) in multiple sclerosis (MS). We found that sCD14 serum levels measured by ELISA were higher in MS patients compared to neurological and healthy controls. Within the MS group sCD14 levels were increased in relapsing-remitting and secondary progressive MS compared to primary progressive MS. Furthermore, sCD14 concentrations were increased during stable disease. An increased expression of sCD14 was also detected after treatment with interferon-beta. In summary, we report evidence that serum sCD14 levels are increased in MS and correlate inversely with disease activity in relapsing MS patients. PMID:17046070

Lutterotti, Andreas; Kuenz, Bettina; Gredler, Viktoria; Khalil, Michael; Ehling, Rainer; Gneiss, Claudia; Egg, Robert; Deisenhammer, Florian; Berger, Thomas; Reindl, Markus

2006-12-01

80

Multiple Episodes of Recent Gully Activity Indicated by Gully Fan Stratigraphy in Eastern Promethei Terra, Mars.  

NASA Astrophysics Data System (ADS)

Introduction Gullies are considered among the youngest geomorphic features on Mars based upon their stratigraphic relationships, superposition on steep slopes and distinctive morphology in unconsolidated sediment. Multiple formation hypotheses have been proposed, which can be divided into three broad classes: entirely dry mechanisms (e.g., [1,2]), wet mechanisms invoking groundwater or ground ice (e.g., [3,4]) and wet mechanisms invoking surficial meltwater (e.g., [5,6,7,8]). It has been difficult to differentiate between these hypotheses based upon past observations and it remains possible that gullies are polygenetic landforms. This study presents stratigraphic relationships in the depositional fan of a crater wall gully system that suggest: (1) multiple episodes of alluvial fan-style deposition, (2) very recent depositional activity that is younger than a newly recognized rayed crater, and (3) surficial snowmelt as the most likely source of these multiple episodes of recent gully activity. Gully-Fan Stratigraphy In Eastern Promethei Terra an ~5 km-diameter crater is observed with a well-developed gully system (Fig. 1) and several smaller gullies in its northnortheast wall. The large gully system (composed of a small western gully and larger eastern gully) shows evidence for incision into the crater wall country rock and has multiple contributory sub-alcoves and channels. The depositional fan associated with this gully system is bounded on its western side by a small arcuate ridge swell that is not observed on the eastern side of the fan. This ridge is interpreted as a moraine-like structure that may have bounded a glacially-formed depression into which the fan is deposited [8]. Similar depressions with bounding ridges are commonly observed in this latitude band (~30-50°S) in association with deeply incised gully alcoves [9,10,11]. This gully fan is composed of multiple lobes with distinct lobe contacts, incised channels, and cut-andfill deposits - all features similar to those seen in terrestrial alluvial fans [12,13]. The western portion of the fan is contained within the depression, while the younger eastern portion overlies and obscures any potential evidence of the ridge structure. A very striking and unusual feature of this gully fan is the large number of superposed impact craters; due to their density and similar diameter, we interpret these to be secondary craters from a large nearby primary impact crater. The depositional lobes of the fan can be divided into two groups: 1) those that predate the secondary crater population and 2) younger lobes that are superposed on the secondary craters. Numerous secondary craters (~1-25 m-diameter) superpose the lowermost stratigraphic lobe (Fig. 1, A), while at least three younger lobes (Fig. 1, C1, D1, and D2) directly superpose the cratered lobe. The emplacement date of these secondaries provides a robust maximum age for the youngest lobes of this fan, and therefore the most recent fluvial activity of the gully. Most gullies either have no superposed impact craters [3,7] or are too small to date with any certainty using crater counts [14]. Therefore, locating and dating the parent impact crater of these secondaries is critical to constrain the chronology and origin of gully systems. Rayed-Crater Source of the Secondary Craters Regional reconnaissance for the origin of the secondary craters led to the discovery of a previously unidentified rayed crater complex (consisting of an ~18 km-diameter outer crater and an ~7 km-diameter inner crater) approximately 175 km southwest of the gully system. Distinctive rays are observed in THEMIS nighttime thermal inertia data, but are not observable as albedo contrasts in THEMIS visible data, consistent with other identifications of young rayed craters on Mars [15,16]. The rims of both craters are distinct and consistent with the morphology of very young impact craters on Mars. The inner crater has a greater depth to diameter ratio than the outer crater (0.121 compared to 0.073), consistent with young Martian craters [17]. Both the ou

Schon, S.; Head, J.; Fassett, C.

2008-09-01

81

Multiple hypothesis tracking for multiple target tracking  

Microsoft Academic Search

Multiple hypothesis tracking (MHT) is generally accepted as the preferred method for solving the data association problem in modern multiple target tracking (MTT) systems. This paper summarizes the motivations for MHT, the basic principles behind MHT and the alternative implementations in common use. It discusses the manner in which the multiple data association hypotheses formed by MHT can be combined

SAMUEL S. BLACKMAN

2004-01-01

82

Evaluating multiple indices of agricultural water use efficiency and productivity to improve comparisons between sites and trends  

NASA Astrophysics Data System (ADS)

Approximately 70% of global available freshwater supplies are used in the agricultural sector. Increased demands for water to meet growing population food requirements, and expected changes in the reliability of freshwater supplies due to climate change, threaten the sustainability of water supplies worldwide - not only on farms, but in connected cities and industries. Researchers concerned with agricultural water use sustainability use a variety of theoretical and empirical measures of efficiency and productivity to gain insight into the sustainability of agricultural water use. However, definitions of measures, or indices, vary between different natural and political boundaries, across regions, states and nations and between their respective research, industry, and environmental groups. Index development responds to local data availability and local agendas, and there is debate about the validity of various indices. However, real differences in empirical index measures are not well-understood across the multiple disciplines that study agricultural water use, including engineering and hydrology, agronomy, climate and soil sciences, and economics. Nevertheless reliable, accessible, and generalizable indices are required for planners and policymakers to promote sustainable water use systems. This study synthesizes a set of water use efficiency and productivity indices based on academic, industry and government literature in California and Australia, two locations with similarly water-stressed and valuable agricultural industries under pressure to achieve optimal water use efficiency and productivity. Empirical data at the irrigation district level from the California San Joaquin Valley and Murray Darling Basin states of Victoria and New South Wales in Australia are used to compute indices that estimate efficiency, yield productivity, and economic productivity of agricultural water use. Multiple index estimates of same time-series data demonstrate historical spread in efficiency and productivity measures in different agricultural regions. Individual indices consistently over- or under- estimate trends in efficiency and productivity by their construction, and may provide inaccurate results in years with extreme climatic events, such as droughts. By treating multiple indices as an "ensemble" of measures, analogous to the treatment of multiple climate model predictions, this study quantifies likely "true" states of efficiency and productivity in the selected agricultural regions, and error in individual indices. While different individual indices are preferable at different scales, and relative to the quality of available input data, ensemble indices can be more reliably used in comparative study across different agricultural regions, and for prediction.

Levy, M. C.

2012-12-01

83

Databased comparison of Sparse Bayesian Learning and Multiple Linear Regression for statistical downscaling of low flow indices  

NASA Astrophysics Data System (ADS)

SummaryThis study attempts to compare the performance of two statistical downscaling frameworks in downscaling hydrological indices (descriptive statistics) characterizing the low flow regimes of three rivers in Eastern Canada - Moisie, Romaine and Ouelle. The statistical models selected are Relevance Vector Machine (RVM), an implementation of Sparse Bayesian Learning, and the Automated Statistical Downscaling tool (ASD), an implementation of Multiple Linear Regression. Inputs to both frameworks involve climate variables significantly (? = 0.05) correlated with the indices. These variables were processed using Canonical Correlation Analysis and the resulting canonical variates scores were used as input to RVM to estimate the selected low flow indices. In ASD, the significantly correlated climate variables were subjected to backward stepwise predictor selection and the selected predictors were subsequently used to estimate the selected low flow indices using Multiple Linear Regression. With respect to the correlation between climate variables and the selected low flow indices, it was observed that all indices are influenced, primarily, by wind components (Vertical, Zonal and Meridonal) and humidity variables (Specific and Relative Humidity). The downscaling performance of the framework involving RVM was found to be better than ASD in terms of Relative Root Mean Square Error, Relative Mean Absolute Bias and Coefficient of Determination. In all cases, the former resulted in less variability of the performance indices between calibration and validation sets, implying better generalization ability than for the latter.

Joshi, Deepti; St-Hilaire, André; Daigle, Anik; Ouarda, Taha B. M. J.

2013-04-01

84

Impact of stimulation versus microswitch-based programs on indices of happiness of people with profound multiple disabilities.  

PubMed

This study was designed to assess whether the impact of a microswitch-based program on indices of happiness would be comparable with that of a stimulation program. Three persons with profound multiple disabilities participated. The microswitch-based program produced increases in indices of happiness which were fairly clear for the first two participants and quite modest for the third participant. These data were largely comparable with those obtained with the stimulation program. Implications of the findings in terms of program practicality, participants' independence and environmental control are discussed. PMID:12061752

Lancioni, Giulio E; O'Reilly, Mark F; Singh, Nirbhay N; Oliva, Doretta; Groeneweg, Jop

2002-01-01

85

Factorial Invariance in Multiple Populations: A Multiple Testing Procedure  

ERIC Educational Resources Information Center

A multiple testing method for examining factorial invariance for latent constructs evaluated by multiple indicators in distinct populations is outlined. The procedure is based on the false discovery rate concept and multiple individual restriction tests and resolves general limitations of a popular factorial invariance testing approach. The…

Raykov, Tenko; Marcoulides, George A.; Millsap, Roger E.

2013-01-01

86

Multiple Source, Multiple Destination Network Tomography  

Microsoft Academic Search

The problem of identifying topology and inferring link-level performance parameters such as packet drop rate or delay variance using only end-to-end measurements is commonly referred to as network tomography. This paper describes a collaborative framework for performing network tomography on topologies with multiple sources and multiple destinations, with- out assuming the topology to be known. Using multiple sources potentially provides

Michael Rabbat; Robert D. Nowak; Mark Coates

2004-01-01

87

Become a Multiplication Wizard!  

NSDL National Science Digital Library

Practice all levels of basic multiplication facts. Are you a math magician? Practice how speedy you can be in Be A Math Magician!. Dress up and race granny in Granny Multiplication Race to make her go faster, answer the problems correctly. Multiplication that makes your mouth water. Multiplication Ice Cream Cones ...

Robinson, Ms.

2010-01-27

88

Analyzing latent state-trait and multiple-indicator latent growth curve models as multilevel structural equation models  

PubMed Central

Latent state-trait (LST) and latent growth curve (LGC) models are frequently used in the analysis of longitudinal data. Although it is well-known that standard single-indicator LGC models can be analyzed within either the structural equation modeling (SEM) or multilevel (ML; hierarchical linear modeling) frameworks, few researchers realize that LST and multivariate LGC models, which use multiple indicators at each time point, can also be specified as ML models. In the present paper, we demonstrate that using the ML-SEM rather than the SL-SEM framework to estimate the parameters of these models can be practical when the study involves (1) a large number of time points, (2) individually-varying times of observation, (3) unequally spaced time intervals, and/or (4) incomplete data. Despite the practical advantages of the ML-SEM approach under these circumstances, there are also some limitations that researchers should consider. We present an application to an ecological momentary assessment study (N = 158 youths with an average of 23.49 observations of positive mood per person) using the software Mplus (Muthén and Muthén, 1998–2012) and discuss advantages and disadvantages of using the ML-SEM approach to estimate the parameters of LST and multiple-indicator LGC models.

Geiser, Christian; Bishop, Jacob; Lockhart, Ginger; Shiffman, Saul; Grenard, Jerry L.

2013-01-01

89

Assessing ecological integrity in marine waters, using multiple indices and ecosystem components: Challenges for the future  

Microsoft Academic Search

During the last decade, there have been substantial scientific advances in the development of indices that measure the condition of biological ecosystem elements in coastal and estuarine waters. Though successful, these advances were only the initial steps and a special session on use of indices in ecological integrity assessments was held at the Coastal and Estuarine Research Federation meeting to

A. Borja; A. Ranasinghe; S. B. Weisberg

2009-01-01

90

Knee-clicks and visual traits indicate fighting ability in eland antelopes: multiple messages and back-up signals  

PubMed Central

Background Given the costs of signalling, why do males often advertise their fighting ability to rivals using several signals rather than just one? Multiple signalling theories have developed largely in studies of sexual signals, and less is known about their applicability to intra-sexual communication. We here investigate the evolutionary basis for the intricate agonistic signalling system in eland antelopes, paying particular attention to the evolutionary phenomenon of loud knee-clicking. Results A principal components analysis separated seven male traits into three groups. The dominant frequency of the knee-clicking sound honestly indicated body size, a main determinant of fighting ability. In contrast, the dewlap size increased with estimated age rather than body size, suggesting that, by magnifying the silhouette of older bulls disproportionately, the dewlap acts as an indicator of age-related traits such as fighting experience. Facemask darkness, frontal hairbrush size and body greyness aligned with a third underlying variable, presumed to be androgen-related aggression. A longitudinal study provided independent support of these findings. Conclusion The results show that the multiple agonistic signals in eland reflect three separate components of fighting ability: (1) body size, (2) age and (3) presumably androgen-related aggression, which is reflected in three backup signals. The study highlights how complex agonistic signalling systems can evolve through the simultaneous action of several selective forces, each of which favours multiple signals. Specifically, loud knee-clicking is discovered to be an honest signal of body size, providing an exceptional example of the potential for non-vocal acoustic communication in mammals.

Bro-J?rgensen, Jakob; Dabelsteen, Torben

2008-01-01

91

Multiple Metal Resistant Transferable Phenotypes in Bacteria as Indicators of Soil Contamination with Heavy Metals (6 pp)  

Microsoft Academic Search

(14%) isolates resistant to zinc, copper, nickel, arsenic and cobalt and site B had no bacteria resistant to all five of these selected metals. The transferability of heavy metal resistance was investigated in the case of 60 multiple heavy metal resistant isolates taken from site A and 50 multiple resistance isolates from site B. Transfer was only detected in isolates

Robert P. Ryan; David J. Ryan; David N. Dowling

2005-01-01

92

Comparison of drought indicators derived from multiple data sets over Africa  

NASA Astrophysics Data System (ADS)

Drought monitoring is a key component to mitigate impacts of droughts. Lack of reliable and up-to-date precipitation data sets is a common challenge across the globe. This study investigates different data sets and drought indicators on their capability to improve drought monitoring in Africa. The study was performed for four river basins located in different climatic regions (the Oum er-Rbia in Morocco, the Blue Nile in eastern Africa, the Upper Niger in western Africa, and the Limpopo in southeastern Africa) as well as the Greater Horn of Africa. The five precipitation data sets compared are the ECMWF ERA-Interim reanalysis, the Tropical Rainfall Measuring Mission satellite monthly rainfall product 3B-43, the Global Precipitation Climatology Centre gridded precipitation data set, the Global Precipitation Climatology Project Global Monthly Merged Precipitation Analyses, and the Climate Prediction Center Merged Analysis of Precipitation. The set of drought indicators used includes the Standardized Precipitation Index, the Standardized Precipitation-Evaporation Index, and Soil Moisture Anomalies. A comparison of the annual cycle and monthly precipitation time series shows a good agreement in the timing of the rainy seasons. The main differences between the data sets are in the ability to represent the magnitude of the wet seasons and extremes. Moreover, for the areas affected by drought, all the drought indicators agree on the time of drought onset and recovery although there is disagreement on the extent of the affected area. In regions with limited rain gauge data the estimation of the different drought indicators is characterized by a higher uncertainty. Further comparison suggests that the main source of differences in the computation of the drought indicators is the uncertainty in the precipitation data sets rather than the estimation of the distribution parameters of the drought indicators.

Naumann, G.; Dutra, E.; Barbosa, P.; Pappenberger, F.; Wetterhall, F.; Vogt, J. V.

2014-05-01

93

Multiple indices of body condition reveal no negative effect of urbanization in adult house sparrows  

Microsoft Academic Search

As urbanized areas expand and develop throughout the world, the importance of understanding their effects on wildlife increases. Living in cities may be stressful for animals but may also provide benefits at the same time, and the sum of these effects should manifest in the body condition of individuals. Studies addressing this phenomenon tend to evaluate one or few indices

Veronika Bókony; Gábor Seress; Szabolcs Nagy; Ádám Z. Lendvai; András Liker

94

Accurate discrimination of conserved coding and non-coding regions through multiple indicators of evolutionary dynamics  

Microsoft Academic Search

BACKGROUND: The conservation of sequences between related genomes has long been recognised as an indication of functional significance and recognition of sequence homology is one of the principal approaches used in the annotation of newly sequenced genomes. In the context of recent findings that the number non-coding transcripts in higher organisms is likely to be much higher than previously imagined,

Matteo Re; Graziano Pesole; David Stephen Horner

2009-01-01

95

Indication of colloidal calcium in freshwaters using multiple processing and analysis tools  

Microsoft Academic Search

Studies of freshwaters indicate that Ca is retained during ultrafiltration together with colloidal material. It has been uncertain however if the retained fraction of Ca is actually associated with the colloidal material or if the enrichment is an artefact. Experimental studies have clearly shown that free Ca ions can be retained during ultrafiltration. This retention is claimed to originate from

R. Dahlqvist; M. Benedetti; K. Andersson; J. Ingri

2003-01-01

96

Inter-comparison of drought indicators derived from multiple precipitation datasets in Africa  

NASA Astrophysics Data System (ADS)

This study investigates the potential of implementing different drought indicators to improve drought monitoring capabilities at continental scale. Several global and continental datasets based on re-analysis, gridded observation, and remote sensing data were tested. At regional level the capabilities of each indicator and dataset on five regions on the African continent (Oum er-rbia, Blue Nile, Upper Niger, Limpopo and the Great Horn of Africa) were compared. The five precipitation datasets used were the ERA - Interim reanalysis (0.5°x0.5° resolution from 1979 to 2010), Tropical Rainfall Measuring Mission (TRMM) satellite monthly rainfall product 3B43 (0.25°x0.25° resolution from 1998 to 2010), the Global Precipitation Climatology Centre (GPCC) gridded precipitation dataset V.5 (1°x1° resolution from 1901 to 2010), the Global Precipitation Climatology Project (GPCP) Global Monthly Merged Precipitation Analyses (2.5°x2.5° resolution from 1979 to 2010), and the Climate Prediction Center Merged Analysis of Precipitation (CMAP, 2.5°x2.5° resolution from 1979 to 2010). The set of indicators proposed included Standardized Precipitation index (SPI), Standardized Precipitation-Evaporation Index (SPEI), Standardized Run-off index (SRI), Soil Moisture Anomalies (SMA). A comparison of the annual cycle and monthly precipitation time series shows a general agreement in the timing of the peaks including the Great Horn of Africa where there are two rainy seasons. The main differences are observed thus in the ability to represent the magnitude of the wet seasons and extremes. Moreover, for the areas that are under drought, all the datasets agree with the certain time of onset and recovery but there are sometimes disagreements on the area affected. The agreement between datasets depends on the threshold selected to define the drought conditions. The comparison between SPI estimations suggest that the main sources of uncertainties (due by lack of ground information, estimation algorithms, parameterization of the convection, etc.) are the differences in the precipitation datasets rather than the estimation of the distribution parameters that defines each indicator. Particularly, the estimations of the indicators over Central Africa reflect the high uncertainty present in the precipitation datasets.

Naumann, Gustavo; Dutra, Emanuel; Barbosa, Paulo; Pappenberger, Florian; Wetterhall, Fredrik

2013-04-01

97

Effects of microswitch-based programs on indices of happiness of students with multiple disabilities: a new research evaluation.  

PubMed

The effects of microswitch-based programs on indices of happiness were evaluated with 9 students who had profound multiple disabilities. Each student received an ABAB sequence in which A represented baseline phases and B, intervention phases. During the latter phases, microswitches were used to enable the students to control preferred environmental stimulation with simple/feasible responses, such as hand-pushing and foot-lifting. Results show that all students increased microswitch responding during the intervention phases. Seven of them also had significant increases in indices of happiness, whereas the other 2 did not. In an attempt to shed some light on the reasons underlying the different outcomes, we examined procedural and methodological aspects of the study. PMID:17542654

Lancioni, Giulio E; Singh, Nirbhay N; O'Reilly, Mark F; Sigafoos, Jeff; Didden, Robert; Oliva, Doretta; Severini, Laura; Smaldone, Angela; Tota, Alessia; Lamartire, Maria L

2007-05-01

98

Multiple applications of Alamar Blue as an indicator of metabolic function and cellular health in cell viability bioassays.  

PubMed

Accurate prediction of the adverse effects of test compounds on living systems, detection of toxic thresholds, and expansion of experimental data sets to include multiple toxicity end-point analysis are required for any robust screening regime. Alamar Blue is an important redox indicator that is used to evaluate metabolic function and cellular health. The Alamar Blue bioassay has been utilized over the past 50 years to assess cell viability and cytotoxicity in a range of biological and environmental systems and in a number of cell types including bacteria, yeast, fungi, protozoa and cultured mammalian and piscine cells. It offers several advantages over other metabolic indicators and other cytotoxicity assays. However, as with any bioassay, suitability must be determined for each application and cell model. This review seeks to highlight many of the important considerations involved in assay use and design in addition to the potential pitfalls. PMID:23112716

Rampersad, Sephra N

2012-01-01

99

Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays  

PubMed Central

Accurate prediction of the adverse effects of test compounds on living systems, detection of toxic thresholds, and expansion of experimental data sets to include multiple toxicity end-point analysis are required for any robust screening regime. Alamar Blue is an important redox indicator that is used to evaluate metabolic function and cellular health. The Alamar Blue bioassay has been utilized over the past 50 years to assess cell viability and cytotoxicity in a range of biological and environmental systems and in a number of cell types including bacteria, yeast, fungi, protozoa and cultured mammalian and piscine cells. It offers several advantages over other metabolic indicators and other cytotoxicity assays. However, as with any bioassay, suitability must be determined for each application and cell model. This review seeks to highlight many of the important considerations involved in assay use and design in addition to the potential pitfalls.

Rampersad, Sephra N.

2012-01-01

100

Suicidality and divalproex sodium: analysis of controlled studies in multiple indications  

PubMed Central

Background Recent analyses of antiepileptic drugs have indicated an increase in the risk of suicidality. The objective of this report was to provide clinical information and an independent meta-analysis of divalproex sodium and suicidality events by analyzing data from 13 placebo-controlled studies and 1 low-dose controlled study. Methods Adverse events considered to be possibly suicide related were identified using the Columbia Classification Algorithm of Suicide Assessment (C-CASA) methodology. Indications included epilepsy, bipolar disorder, migraine prophylaxis, impulsive aggression, and dementia. Narratives were produced for every event, and suicidality event ratings were performed by a third party blinded to treatment assignment. Statistical analyses were conducted using methodology similar to that reported by the US Food and Drug Administration (FDA). Results Suicidality events were identified in 5 of the 13 placebo-controlled studies. Of the 1,327 (0.83%) subjects taking divalproex sodium, 11 had suicidality events: 2 suicide attempts and 9 suicidal ideation. Of 992 (0.91%) subjects taking placebo, 9 had suicidality events: 1 preparatory act toward suicide, 2 suicide attempts, and 6 suicidal ideation. Across placebo-controlled studies, the overall estimated odds ratio (OR) of suicidal behavior or ideation was 0.72 (95% CI 0.29 to 1.84). The OR for suicidal behavior was 0.37 (95% CI 0.04 to 2.58), and the OR for suicidal ideation was 0.90 (95% CI 0.31 to 2.79). Conclusions In this meta-analysis, divalproex sodium does not appear to increase the risk of suicide-related adverse events relative to placebo in the populations studied. Clinicians should nonetheless remain vigilant in assessing suicidality, not only in patients treated for mental disorders with inherently high suicide risk, but also in patients taking antiepileptic medications.

2011-01-01

101

Indication of colloidal calcium in freshwaters using multiple processing and analysis tools  

NASA Astrophysics Data System (ADS)

Studies of freshwaters indicate that Ca is retained during ultrafiltration together with colloidal material. It has been uncertain however if the retained fraction of Ca is actually associated with the colloidal material or if the enrichment is an artefact. Experimental studies have clearly shown that free Ca ions can be retained during ultrafiltration. This retention is claimed to originate from electrostatic repulsion of sulphate ions by the filtration membrane, with subsequent retention of cations (including Ca) to maintain charge balance in the solution. But other studies of natural freshwaters suggest that there might also be a true colloidal fraction of Ca present. An obvious problem would be to distinguish the two causes of retention from each other. The Ca speciation in the Amazon/Purús rivers and the Kalix river (a boreal river in northern Sweden) was compared using combined analysis with ICP-MS and Ca ISE (ion-selective electrode). Analysis was performed on unfiltered samples and on solutions from cross-flow ultrafiltration experiments. Results obtained from this combined analysis of unfiltered samples from the Amazon/Púrus and Kalix rivers are in excellent agreement with each other and indicate that on average about 84% of the total Ca is in true dissolved form. The newly developed combination of flow field-flow fractionation (FlFFF) coupled on-line to ICP-MS has been used to study the size distribution and nature of colloidal material in the Kalix river. Mainly two types of colloids are present in this river. A carbon rich form, probably consisting of humic substances, and a Fe-rich form which is larger. Size distribution spectra produced with FlFFF ICP-MS show that a fraction of Ca is associated with the smaller organic rich colloidal phase. ICP-MS and ISE analysis from ultrafiltered retentate fractions show that colloidal Ca as well as free Ca2+ ions are enriched during cross-flow ultrafiltration. The results give important information about how ultrafiltration affects the sample during processing and has implications for the quantification of the colloidal fraction. The use of ISE makes colloidal quantification of Ca possible.

Dahlqvist, R.; Benedetti, M.; Andersson, K.; Ingri, J.

2003-04-01

102

Complete mitochondrial genome phylogeographic analysis of killer whales (Orcinus orca) indicates multiple species  

PubMed Central

Killer whales (Orcinus orca) currently comprise a single, cosmopolitan species with a diverse diet. However, studies over the last 30 yr have revealed populations of sympatric “ecotypes” with discrete prey preferences, morphology, and behaviors. Although these ecotypes avoid social interactions and are not known to interbreed, genetic studies to date have found extremely low levels of diversity in the mitochondrial control region, and few clear phylogeographic patterns worldwide. This low level of diversity is likely due to low mitochondrial mutation rates that are common to cetaceans. Using killer whales as a case study, we have developed a method to readily sequence, assemble, and analyze complete mitochondrial genomes from large numbers of samples to more accurately assess phylogeography and estimate divergence times. This represents an important tool for wildlife management, not only for killer whales but for many marine taxa. We used high-throughput sequencing to survey whole mitochondrial genome variation of 139 samples from the North Pacific, North Atlantic, and southern oceans. Phylogenetic analysis indicated that each of the known ecotypes represents a strongly supported clade with divergence times ranging from ?150,000 to 700,000 yr ago. We recommend that three named ecotypes be elevated to full species, and that the remaining types be recognized as subspecies pending additional data. Establishing appropriate taxonomic designations will greatly aid in understanding the ecological impacts and conservation needs of these important marine predators. We predict that phylogeographic mitogenomics will become an important tool for improved statistical phylogeography and more precise estimates of divergence times.

Morin, Phillip A.; Archer, Frederick I.; Foote, Andrew D.; Vilstrup, Julia; Allen, Eric E.; Wade, Paul; Durban, John; Parsons, Kim; Pitman, Robert; Li, Lewyn; Bouffard, Pascal; Abel Nielsen, Sandra C.; Rasmussen, Morten; Willerslev, Eske; Gilbert, M. Thomas P.; Harkins, Timothy

2010-01-01

103

Accurate discrimination of conserved coding and non-coding regions through multiple indicators of evolutionary dynamics  

PubMed Central

Background The conservation of sequences between related genomes has long been recognised as an indication of functional significance and recognition of sequence homology is one of the principal approaches used in the annotation of newly sequenced genomes. In the context of recent findings that the number non-coding transcripts in higher organisms is likely to be much higher than previously imagined, discrimination between conserved coding and non-coding sequences is a topic of considerable interest. Additionally, it should be considered desirable to discriminate between coding and non-coding conserved sequences without recourse to the use of sequence similarity searches of protein databases as such approaches exclude the identification of novel conserved proteins without characterized homologs and may be influenced by the presence in databases of sequences which are erroneously annotated as coding. Results Here we present a machine learning-based approach for the discrimination of conserved coding sequences. Our method calculates various statistics related to the evolutionary dynamics of two aligned sequences. These features are considered by a Support Vector Machine which designates the alignment coding or non-coding with an associated probability score. Conclusion We show that our approach is both sensitive and accurate with respect to comparable methods and illustrate several situations in which it may be applied, including the identification of conserved coding regions in genome sequences and the discrimination of coding from non-coding cDNA sequences.

Re, Matteo; Pesole, Graziano; Horner, David S

2009-01-01

104

Complete mitochondrial genome phylogeographic analysis of killer whales (Orcinus orca) indicates multiple species.  

PubMed

Killer whales (Orcinus orca) currently comprise a single, cosmopolitan species with a diverse diet. However, studies over the last 30 yr have revealed populations of sympatric "ecotypes" with discrete prey preferences, morphology, and behaviors. Although these ecotypes avoid social interactions and are not known to interbreed, genetic studies to date have found extremely low levels of diversity in the mitochondrial control region, and few clear phylogeographic patterns worldwide. This low level of diversity is likely due to low mitochondrial mutation rates that are common to cetaceans. Using killer whales as a case study, we have developed a method to readily sequence, assemble, and analyze complete mitochondrial genomes from large numbers of samples to more accurately assess phylogeography and estimate divergence times. This represents an important tool for wildlife management, not only for killer whales but for many marine taxa. We used high-throughput sequencing to survey whole mitochondrial genome variation of 139 samples from the North Pacific, North Atlantic, and southern oceans. Phylogenetic analysis indicated that each of the known ecotypes represents a strongly supported clade with divergence times ranging from approximately 150,000 to 700,000 yr ago. We recommend that three named ecotypes be elevated to full species, and that the remaining types be recognized as subspecies pending additional data. Establishing appropriate taxonomic designations will greatly aid in understanding the ecological impacts and conservation needs of these important marine predators. We predict that phylogeographic mitogenomics will become an important tool for improved statistical phylogeography and more precise estimates of divergence times. PMID:20413674

Morin, Phillip A; Archer, Frederick I; Foote, Andrew D; Vilstrup, Julia; Allen, Eric E; Wade, Paul; Durban, John; Parsons, Kim; Pitman, Robert; Li, Lewyn; Bouffard, Pascal; Abel Nielsen, Sandra C; Rasmussen, Morten; Willerslev, Eske; Gilbert, M Thomas P; Harkins, Timothy

2010-07-01

105

The Effects of Multiple Cold Water Immersions on Indices of Muscle Damage  

PubMed Central

The aim of this investigation was to elucidate the efficacy of repeated cold water immersions (CWI) in the recovery of exercise induced muscle damage. A randomised group consisting of eighteen males, mean ± s age, height and body mass were 24 ± 5 years, 1.82 ± 0.06 m and 85.7 ± 16.6 kg respectively, completed a bout of 100 drop jumps. Following the bout of damaging exercise, participants were randomly but equally assigned to either a 12 min CWI (15 ± 1 °C; n = 9) group who experienced immersions immediately post-exercise and every 24 h thereafter for the following 3 days, or a control group (no treatment; n = 9). Maximal voluntary contraction (MVC) of the knee extensors, creatine kinase activity (CK), muscle soreness (DOMS), range of motion (ROM) and limb girth were measured pre-exercise and then for the following 96 h at 24 h increments. In addition MVC was also recorded immediately post-exercise. Significant time effects were seen for MVC, CK, DOMS and limb girth (p < 0.05) indicating muscle damage was evident, however there was no group effect or interaction observed showing that CWI did not attenuate any of the dependent variables (p > 0.05). These results suggest that repeated CWI do not enhance recovery from a bout of damaging eccentric contractions. Key pointsCryotherapy, particularly cold water immersions are one of the most common interventions used in order to enhance recovery post-exercise.There is little empirical evidence demonstrating benefits from cold water immersions. Research evidence is equivocal, probably due to methodological inconsistencies.Our results show that the cryotherapy administered did not attenuate any markers of EIMD or enhance the recovery of function.We conclude that repeated cold water immersions are ineffective in the recovery from heavy plyometric exercise and suggest athletes and coaches should use caution before using this intervention as a recovery strategy

Goodall, Stuart; Howatson, Glyn

2008-01-01

106

Topographic Roughness of Hawaiian Volcanic Terrains: Analysis of Multiple Datasets Indicates Length Scales are Critical  

NASA Astrophysics Data System (ADS)

The roughness of a natural surface is often defined by the topography of the surface at scales of a few tens of meters or less. To ensure the safety of rovers and scientific instruments on Mars, these scales are of critical importance during landing site selection and rover traverse operations. Published work on terrestrial and Martian topography datasets has demonstrated that statistical values such as the Hurst exponent can be used in conjunction with related statistical measures such as RMS slope or deviation to quantify the relationship between scale-dependent roughness values and the morphology of a surface. In our detailed studies of the statistical behavior of meter-scale surface roughness on Earth, we determine that the length scales used to calculate the surface roughness affect the resulting roughness statistics and must be taken into account when analyzing planetary surface roughness. Extensive airborne Light Detection and Ranging (a-LiDAR) coverage of the summit of Kilauea volcano on the Big Island of Hawaii (1 m DEM) provides an opportunity for simulating higher resolution Martian topography data such as will be obtained from photoclinometry and stereo imaging using the HiRISE camera on MRO. In addition to the a-LiDAR data, we use high-resolution topography (2 cm DEM) generated from a tripod-mounted scanning LiDAR system (t-LiDAR). Previous authors have described techniques for calculating roughness statistics in one dimension using topographic profiles. We adapt the 1D method for use with 2D topographic datasets to generate maps of the Hurst exponent of Martian analog flows in Hawaii. Results from the surface roughness analysis suggest that the calculated RMS deviation or slope and Hurst exponent exhibit systematic variations as the length of a profile segment (in 1D studies) or size of the cell (in 2D studies) changes. These new results, combined with previously described data, indicate that the length scales used to calculate roughness statistics must be accounted for when describing the statistical behavior of a planetary surface.

Morris, A. R.; Anderson, F. S.; Mouginis-Mark, P.; Haldemann, A.; Brooks, B.; Foster, J.

2007-12-01

107

Multiple-Ring Digital Communication Network  

NASA Technical Reports Server (NTRS)

Optical-fiber digital communication network to support data-acquisition and control functions of electric-power-distribution networks. Optical-fiber links of communication network follow power-distribution routes. Since fiber crosses open power switches, communication network includes multiple interconnected loops with occasional spurs. At each intersection node is needed. Nodes of communication network include power-distribution substations and power-controlling units. In addition to serving data acquisition and control functions, each node acts as repeater, passing on messages to next node(s). Multiple-ring communication network operates on new AbNET protocol and features fiber-optic communication.

Kirkham, Harold

1992-01-01

108

Practice Parameters for the Non-Respiratory Indications for Polysomnography and Multiple Sleep Latency Testing for Children  

PubMed Central

Background: Although a level 1 nocturnal polysomnogram (PSG) is often used to evaluate children with non-respiratory sleep disorders, there are no published evidence-based practice parameters focused on the pediatric age group. In this report, we present practice parameters for the indications of polysomnography and the multiple sleep latency test (MSLT) in the assessment of non-respiratory sleep disorders in children. These practice parameters were reviewed and approved by the Board of Directors of the American Academy of Sleep Medicine (AASM). Methods: A task force of content experts was appointed by the AASM to review the literature and grade the evidence according to the American Academy of Neurology grading system. Recommendations For PSG and MSLT Use: PSG is indicated for children suspected of having periodic limb movement disorder (PLMD) for diagnosing PLMD. (STANDARD) The MSLT, preceded by nocturnal PSG, is indicated in children as part of the evaluation for suspected narcolepsy. (STANDARD) Children with frequent NREM parasomnias, epilepsy, or nocturnal enuresis should be clinically screened for the presence of comorbid sleep disorders and polysomnography should be performed if there is a suspicion for sleep-disordered breathing or periodic limb movement disorder. (GUIDELINE) The MSLT, preceded by nocturnal PSG, is indicated in children suspected of having hypersomnia from causes other than narcolepsy to assess excessive sleepiness and to aid in differentiation from narcolepsy. (OPTION) The polysomnogram using an expanded EEG montage is indicated in children to confirm the diagnosis of an atypical or potentially injurious parasomnia or differentiate a parasomnia from sleep-related epilepsy (OPTION) Polysomnography is indicated in children suspected of having restless legs syndrome (RLS) who require supportive data for diagnosing RLS. (OPTION) Recommendations Against PSG Use: Polysomnography is not routinely indicated for evaluation of children with sleep-related bruxism. (STANDARD) Conclusions: The nocturnal polysomnogram and MSLT are useful clinical tools for evaluating pediatric non-respiratory sleep disorders when integrated with the clinical evaluation. Citation: Aurora RN; Lamm CI; Zak RS; Kristo DA; Bista SR; Rowley JA; Casey KR. Practice parameters for the non-respiratory indications for polysomnography and multiple sleep latency testing for children. SLEEP 2012;35(11):1467-1473.

Aurora, R. Nisha; Lamm, Carin I.; Zak, Rochelle S.; Kristo, David A.; Bista, Sabin R.; Rowley, James A.; Casey, Kenneth R.

2012-01-01

109

Challenges of Parenting Multiples  

MedlinePLUS

... the American Society for Reproductive Medicine Challenges of Parenting Multiples There are many psychological, social, and economic ... the unique challenges and rewards that come from parenting multiples. For more information on the medical aspects ...

110

Multiple sclerosis - discharge  

MedlinePLUS

MS - discharge ... Your doctor has told you that you have multiple sclerosis. This disease affects the brain and spinal cord ( ... bladder is not working correctly. Some people with multiple sclerosis need to use a urinary catheter . This is ...

111

Fatigue and Multiple Sclerosis  

MedlinePLUS

Fatigue - National Multiple Sclerosis Society Skip to navigation Skip to content Menu Navigation National Multiple Sclerosis Society ... Twitter Email Home Symptoms & Diagnosis MS Symptoms Fatigue Fatigue Share Smaller Text Larger Text Print In this ...

112

Multiple Access Trade Study.  

National Technical Information Service (NTIS)

The Personal Access Satellite System (PASS) strawman design uses a hybrid Time Division Multiple Access (TDMA)/Frequency Division Multiple Access (FDMA) implementation. TDMA is used for the forward direction (from Suppliers to Users), and FDMA for the ret...

M. Motamedi

1990-01-01

113

Preparing for Multiple Births  

MedlinePLUS

... a common term for triplets and other higher-order multiple births, such as quadruplets or quintuplets. These babies can ... higher risk of enduring health problems with higher-order multiple births. Because of these concerns, many doctors who specialize ...

114

Multiple secret images in multiple sharing images  

NASA Astrophysics Data System (ADS)

Internet based communications are evolving at a tremendous rate. Encryption of data has become an important way to protect data resources especially on the Internet, intranets and extranets. Steganography is a process of hiding data inside a sharing medium. A technique of hiding multiple images in multiple sharing images is proposed. A covering image of pixel area greater than twice a secret image is chosen which enables embedding multiple secret images inside. Multiple secret images are encrypted using simple XOR operations over the covering images. The covering images are transmitted over the communication medium to the authenticated user base on key management. The decryption resolves the secret images to the user at the other end. The scheme suffers one bit information loss which happens in the last bit of the byte which is negligible.

Velswamy, Rajasekar; Sellappan, Selvarajan; Sengottaiyan, Karthiprem; Muthusamy, Suganthi

2012-04-01

115

Multiple Instance Regression  

Microsoft Academic Search

This paper introduces multiple instance re- gression, a variant of multiple regression in which each data point may be described by more than one vector of values for the inde- pendent variables. The goals of this work are to (1) understand the computational com- plexity of the multiple instance regression task and (2) develop an ecien t algorithm that is

Soumya Ray; David Page

2001-01-01

116

Multiple-Human Tracking Using Multiple Cameras  

Microsoft Academic Search

We propose a human motion detection method using multiple-viewpoint images. In vision-based human tracking, self-occlusions and human-human occlusions are a part of the more significant problems. Employing multiple viewpoints and a viewpoint selection mechanism, however, can reduce these problems. The vision system in this case should select the best viewpoints for extracting human motion information; the “best” selections can be

Akira Utsumi; Hiroki Mori; Jun Ohya; Masahiko Yachida

1998-01-01

117

Multiple Core Galaxies  

NASA Technical Reports Server (NTRS)

Nuclei of galaxies often show complicated density structures and perplexing kinematic signatures. In the past we have reported numerical experiments indicating a natural tendency for galaxies to show nuclei offset with respect to nearby isophotes and for the nucleus to have a radial velocity different from the galaxy's systemic velocity. Other experiments show normal mode oscillations in galaxies with large amplitudes. These oscillations do not damp appreciably over a Hubble time. The common thread running through all these is that galaxies often show evidence of ringing, bouncing, or sloshing around in unexpected ways, even though they have not been disturbed by any external event. Recent observational evidence shows yet another phenomenon indicating the dynamical complexity of central regions of galaxies: multiple cores (M31, Markarian 315 and 463 for example). These systems can hardly be static. We noted long-lived multiple core systems in galaxies in numerical experiments some years ago, and we have more recently followed up with a series of experiments on multiple core galaxies, starting with two cores. The relevant parameters are the energy in the orbiting clumps, their relative.masses, the (local) strength of the potential well representing the parent galaxy, and the number of cores. We have studied the dependence of the merger rates and the nature of the final merger product on these parameters. Individual cores survive much longer in stronger background potentials. Cores can survive for a substantial fraction of a Hubble time if they travel on reasonable orbits.

Miller, R.H.; Morrison, David (Technical Monitor)

1994-01-01

118

Role of the hepatic artery in canalicular bile formation by the perfused rat liver. A multiple indicator dilution study.  

PubMed Central

The role of the hepatic artery in tracer water exchange and regulation of permeation of small solutes during canalicular bile formation was studied in the rat using a system that permitted perfusion of both hepatic artery and portal vein. Hepatic vein and biliary multiple indicator dilution curves were obtained after injection of indicators into either vessel. The main difference in hepatic venous dilution curves was a 3.1-fold longer t0 (time spent in nonexchanging vessels) and a 5% larger equivalent water space after injection into the hepatic artery. Biliary tracer recovery of water was markedly higher after arterial injection than after portal vein injection. Both taurocholate and taurodehydrocholate stimulated bile flow and increased biliary tracer recovery after injection into either vessel. The biliary recovery of sucrose relative to that of water, which is a measure of biliary sucrose permeation, was much lower when given into the hepatic artery than when given into the portal vein. During taurocholate infusion, it decreased by 33% in the hepatic artery but increased 36% in the portal vein. Taurodehydrocholate, by contrast, did not affect permeation of sucrose given into the portal vein. Our studies demonstrate marked exchange of tracer water in the biliary epithelium. Taurocholate, but not taurodehydrocholate, increases permeation of sucrose into bile in the portal vein bed while both bile salts decrease it in the arterial bed. Images

Reichen, J

1988-01-01

119

Quantifying and modeling long-range cross correlations in multiple time series with applications to world stock indices  

NASA Astrophysics Data System (ADS)

We propose a modified time lag random matrix theory in order to study time-lag cross correlations in multiple time series. We apply the method to 48 world indices, one for each of 48 different countries. We find long-range power-law cross correlations in the absolute values of returns that quantify risk, and find that they decay much more slowly than cross correlations between the returns. The magnitude of the cross correlations constitutes “bad news” for international investment managers who may believe that risk is reduced by diversifying across countries. We find that when a market shock is transmitted around the world, the risk decays very slowly. We explain these time-lag cross correlations by introducing a global factor model (GFM) in which all index returns fluctuate in response to a single global factor. For each pair of individual time series of returns, the cross correlations between returns (or magnitudes) can be modeled with the autocorrelations of the global factor returns (or magnitudes). We estimate the global factor using principal component analysis, which minimizes the variance of the residuals after removing the global trend. Using random matrix theory, a significant fraction of the world index cross correlations can be explained by the global factor, which supports the utility of the GFM. We demonstrate applications of the GFM in forecasting risks at the world level, and in finding uncorrelated individual indices. We find ten indices that are practically uncorrelated with the global factor and with the remainder of the world indices, which is relevant information for world managers in reducing their portfolio risk. Finally, we argue that this general method can be applied to a wide range of phenomena in which time series are measured, ranging from seismology and physiology to atmospheric geophysics.

Wang, Duan; Podobnik, Boris; Horvati?, Davor; Stanley, H. Eugene

2011-04-01

120

6.NS Multiples and Common Multiples  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: List all the multiples of 8 that are less than or equal to 100. List all the multiples of 12 that are less than or equal to 100. What are the common mu...

121

ALGORITHMS FOR MATRIX MULTIPLICATION  

Microsoft Academic Search

Strassen's and Winograd's algorithms for n ? n matrix multiplication are investigated and compared with the normal algorithm. The normal algorithm requires n3 + O(n2) multiplications and about the same number of additions. Winograd's algorithm almost halves the number of multiplications at the expense of more additions. Strassen's algorithm reduces the total number of operations to O(n2.82) by recursively multiplying

R. P. BRENT

1970-01-01

122

Fun with Multiplication Facts  

NSDL National Science Digital Library

We are going to practice our multiplication facts by having fun in the jungle! Drummin Up Our Multiplication Facts will help Jungle Jim as he beats his drums to learn his facts After you have helped Jungle Jim with his drums, join Jungle Jim and the Monkeys of Monamona while Swinging with Fact Families Memorize Multiplication Facts for extra practice after you have helped Jungle Jim! ...

Shields, Ms.

2007-10-25

123

How accurately can the diffusion profiles indicate multiple fiber orientations? A study on general fiber crossings in diffusion MRI  

Microsoft Academic Search

The q-space imaging techniques and high angular resolution diffusion (HARD) imaging have shown promise to identify intravoxel multiple fibers. The measured orientation distribution function (ODF) and apparent diffusion coefficient (ADC) profiles can be used to identify the orientations of the actual intravoxel fibers. The present study aims to examine the accuracy of these profile-based orientation methods by comparing the angular

Wang Zhan; Yihong Yang

2006-01-01

124

Isolated Head Injuries versus Multiple Trauma in Pediatric Patients: Do the Same Indications for Cervical Spine Evaluation Apply?  

Microsoft Academic Search

Although the recommendations to evaluate possible cervical spine injuries in patients with isolated head injuries are identical to those with multiple trauma, to date, no such study has confirmed that risk factors are the same for both injuries. We reviewed the charts of 268 pediatric patients with isolated head injuries admitted to the Intensive Care Unit at Children’s Hospital Medical

James L. Laham; Dennis H. Cotcamp; Patricia A. Gibbons; Madelyn D. Kahana; Kerry R. Crone

1994-01-01

125

Mature plasma cells as indicator of better prognosis in multiple myeloma. New methodology for the assessment of plasma cell morphology  

Microsoft Academic Search

The relationship between plasmablastic cells and outcome in multiple myeloma (MM) has been established for nearly 15 years. But the assessment of these cells is not easy to perform and it allows the identification of only a small proportion of patients. We investigated the plasma cell morphology using a progressive evaluation of consecutive criteria: nucleolus, chromatin and nuclear-cellular ratio (N\\/C).

Jean E Goasguen; Marc Zandecki; Claire Mathiot; Jean-Marie Scheiff; Marie Bizet; Béatrice Ly-Sunnaram; Bernard Grosbois; Matthieu Monconduit; Jean-Louis Michaux; Thierry Facon

1999-01-01

126

The use of multiple indices of physiological activity to access viability in chlorine disinfected Escherichia coli O157:H7  

NASA Technical Reports Server (NTRS)

A suite of fluorescent intracellular stains and probes was used, in conjunction with viable plate counts, to assess the effect of chlorine disinfection on membrane potential (rhodamine 123; Rh123 and bis-(1,3-dibutylbarbituric acid) trimethine oxonol; DiBAC4(3)), membrane integrity (LIVE/DEAD BacLight kit), respiratory activity (5-cyano-2,3-ditolyl tetrazolium chloride; CTC) and substrate responsiveness (direct viable counts; DVC) in the commensal pathogen Escherichia coli O157:H7. After a 5 min exposure to the disinfectant, physiological indices were affected in the following order: viable plate counts > substrate responsiveness > membrane potential > respiratory activity > membrane integrity. In situ assessment of physiological activity by examining multiple targets, as demonstrated in this study, permits a more comprehensive determination of the site and extent of injury in bacterial cells following sublethal disinfection with chlorine. This approach to assessing altered bacterial physiology has application in various fields where detection of stressed bacteria is of interest.

Lisle, J. T.; Pyle, B. H.; McFeters, G. A.

1999-01-01

127

IRON IN MULTIPLE MYELOMA  

PubMed Central

Multiple myeloma is a non-curable B cell malignancy in which iron metabolism plays an important role. Patients with this disorder almost universally suffer from a clinically significant anemia, which is often symptomatic, and which is due to impaired iron utilization. Recent studies indicate that the proximal cause of dysregulated iron metabolism and anemia in these patients is cytokine-induced upregulation of hepcidin expression. Malignant myeloma cells are dependent on an increased influx of iron and therapeutic efforts are being made to target this requirement. The studies detailing the characteristics and biochemical abnormalities in iron metabolism causing anemia and the initial attempts to target iron therapeutically are described in this review.

VanderWall, Kristina; Daniels-Wells, Tracy R; Penichet, Manuel; Lichtenstein, Alan

2013-01-01

128

The Empirical Power and Type I Error Rates of the GBT and [omega] Indices in Detecting Answer Copying on Multiple-Choice Tests  

ERIC Educational Resources Information Center

The generalized binomial test (GBT) and [omega] indices are the most recent methods suggested in the literature to detect answer copying behavior on multiple-choice tests. The [omega] index is one of the most studied indices, but there has not yet been a systematic simulation study for the GBT index. In addition, the effect of the ability levels…

Zopluoglu, Cengiz; Davenport, Ernest C., Jr.

2012-01-01

129

On Multiple-Layered Vortices  

NASA Technical Reports Server (NTRS)

As part of an ongoing effort to find ways to make vortex flow fields decompose more quickly, photographs and observations are presented of vortex flow fields that indicate the presence of multiple layers of fluid rotating about a common axis. A survey of the literature indicates that multiple-layered vortices form in waterspouts, tornadoes and lift-generated vortices of aircraft. An explanation for the appearance of multiple-layered structures in vortices is suggested. The observations and data presented are intended to improve the understanding of the formation and persistence of vortex flow fields.

Rossow, Vernon J.

2011-01-01

130

Multiple Linear Regression  

NSDL National Science Digital Library

This site, created by Michelle Lacey of Yale University, gives an explanation, a definition and an example of multiple linear regression. Topics include: confidence intervals, tests of significance, and squared multiple correlation. While brief, this is still a valuable site for anyone interested in statistics.

Lacey, Michelle

2009-11-30

131

Multiple density layered insulator  

DOEpatents

A multiple density layered insulator for use with a laser is disclosed which provides at least two different insulation materials for a laser discharge tube, where the two insulation materials have different thermoconductivities. The multiple layer insulation materials provide for improved thermoconductivity capability for improved laser operation. 4 figs.

Alger, T.W.

1994-09-06

132

Multiple density layered insulator  

DOEpatents

A multiple density layered insulator for use with a laser is disclosed wh provides at least two different insulation materials for a laser discharge tube, where the two insulation materials have different thermoconductivities. The multiple layer insulation materials provide for improved thermoconductivity capability for improved laser operation.

Alger, Terry W. (Tracy, CA)

1994-01-01

133

Applying Multiple Intelligences  

ERIC Educational Resources Information Center

The ideas of multiple intelligences introduced by Howard Gardner of Harvard University more than 25 years ago have taken form in many ways, both in schools and in other sometimes-surprising settings. The silver anniversary of Gardner's learning theory provides an opportunity to reflect on the ways multiple intelligences theory has taken form and…

Christodoulou, Joanna A.

2009-01-01

134

Multiplate Antenna Feed.  

National Technical Information Service (NTIS)

The report describes the design of a multiplate antenna feed system which consists of tower- and ground-mounted equipment. The feed illuminates each of four elliptical multiplate apertures on the ground, producing a single beam on transmit, and a square c...

S. Milazzo J. Lory C. Rothenberg J. Kearney

1964-01-01

135

Problem with Multiple Robots.  

National Technical Information Service (NTIS)

The issues that can arise in research associated with multiple, robotic agents are discussed. Two particular multi-robot projects are presented as examples. This paper was written in the hope that it might ease the transition from single to multiple robot...

M. J. Huber P. G. Kenny

1994-01-01

136

Reconstruction of advance head and neck cancer patients after tumor ablation with simultaneous multiple free flaps: indications and prognosis.  

PubMed

Simultaneous multiple free flaps have become a useful option in head and neck reconstructions. We performed a 10-year retrospective study between 2001 and 2010. There were 58 men and 1 woman. The overall mortality rate was 51.7%. The longest surviving patient is 9 years and 4 months, whereas the shortest surviving patient was 72 days. The mean survival period was 47.1 (6.8) months. Age (P = 0.755) and tumor size (P = 0.115) did not play a major role, but surgical margin, lymph node, and tumor recurrence were significant in patient survival with a P value of 0.026, 0.01, and 0.026, respectively. If wide excision with a margin that can be free of tumor can be performed, lymph nodes are not involved, and this is a primary tumor, then time and effort should be spent in a successful simultaneous multiple free flap reconstruction. PMID:23154330

Chien, Sou-Hsin; Hsu, Honda; Huang, Chieh-Chi; Lee, Cheng-Yung; Chiu, Chih-Hung Mark; Lin, Chih-Ming

2012-12-01

137

How accurately can the diffusion profiles indicate multiple fiber orientations? A study on general fiber crossings in diffusion MRI  

NASA Astrophysics Data System (ADS)

The q-space imaging techniques and high angular resolution diffusion (HARD) imaging have shown promise to identify intravoxel multiple fibers. The measured orientation distribution function (ODF) and apparent diffusion coefficient (ADC) profiles can be used to identify the orientations of the actual intravoxel fibers. The present study aims to examine the accuracy of these profile-based orientation methods by comparing the angular deviations between the estimated local maxima of the profiles and the real fiber orientation for a fiber crossing simulated with various intersection angles under different b values in diffusion-weighted MRI experiments. Both noisy and noise-free environments were investigated. The diffusion spectrum imaging (DSI), q-ball imaging (QBI), and HARD techniques were used to generate ODF and ADC profiles. To provide a better comparison between ODF and ADC techniques, the phase-corrected angular deviations were also presented for the ADC method based on a circular spectrum mapping method. The results indicate that systematic angular deviations exist between the actual fiber orientations and the corresponding local maxima of either the ADC or ODF profiles. All methods are apt to underestimation of acute intersection and overestimation of obtuse intersection angle. For a typical slow-exchange fiber crossing, the ODF methods have a non-deviation zone around the 90° intersection. Before the phase-correction, the deviation of ADC profiles approaches a peak at the 90° intersection, while after the correction the ADC deviations are significantly reduced. When the b factor is larger than 1000 s/mm 2, the ODF methods have smaller angular deviations than the ADC methods for the intersections close to 90°. QBI method demonstrates a slight yet consistent advantage over the DSI method under the same conditions. In the noisy environment, the mean value of the deviation angles shows a high consistency with the corresponding deviation in the nose-free condition.

Zhan, Wang; Yang, Yihong

2006-12-01

138

Multiple-indicator dilution technique for characterization of normal and retrograde flow in once-through rat liver perfusions  

SciTech Connect

The technique of normal and retrograde rat liver perfusion has been widely used to probe zonal differences in drug-metabolizing activities. The validity of this approach mandates the same tissue spaces being accessed by substrates during both normal and retrograde perfusions. Using the multiple-indicator dilution technique, we presently examine the extent to which retrograde perfusion alters the spaces accessible to noneliminated references. A bolus dose of 51Cr-labeled red blood cells, 125I-albumin, 14C-sucrose and 3H2O was injected into the portal (normal) or hepatic (retrograde) vein of rat livers perfused at 10 ml per min per liver. The outflow perfusate was serially collected over 220 sec to characterize the transit times and the distribution spaces of the labels. During retrograde perfusion, red blood cells, albumin and sucrose profiles peaked later and lower than during normal perfusion, whereas the water curves were similar. The transit times of red blood cells, albumin and sucrose were longer (p less than 0.005), whereas those for water did not change. Consequently, retrograde flow resulted in significantly larger sinusoidal blood volumes (45%), albumin Disse space (42%) and sucrose Disse space (25%) than during normal flow, whereas the distribution spaces for total and intracellular water remained unaltered. The distension of the vascular tree was confirmed by electron microscopy, by which occasional isolated foci of widened intercellular recesses and spaces of Disse were observed. Cellular ultrastructure was otherwise unchanged, and there was no difference found between normal and retrograde perfusion for bile flow rates, AST release, perfusion pressure, oxygen consumption and metabolic removal of ethanol, a substrate with flow-limited distribution, which equilibrates rapidly with cell water (hepatic extraction ratios were virtually identical: normal vs. retrograde, 0.50 vs. 0.48 at 6 to 7.4 mM input concentration).

St-Pierre, M.V.; Schwab, A.J.; Goresky, C.A.; Lee, W.F.; Pang, K.S.

1989-02-01

139

Multiple scattering tomography.  

PubMed

Multiple scattering represents a challenge for numerous modern tomographic imaging techniques. In this Letter, we derive an appropriate line integral that allows for the tomographic reconstruction of angular resolved scattering distributions, even in the presence of multiple scattering. The line integral is applicable to a wide range of imaging techniques utilizing various kinds of probes. Here, we use x-ray grating interferometry to experimentally validate the framework and to demonstrate additional structural sensitivity, which exemplifies the impact of multiple scattering tomography. PMID:25062159

Modregger, Peter; Kagias, Matias; Peter, Silvia; Abis, Matteo; Guzenko, Vitaliy A; David, Christian; Stampanoni, Marco

2014-07-11

140

Gd13Fe10C13: indications of Fe-Fe multiple bonding emerging from chemical frustration.  

PubMed

We report the synthesis and crystal structure of the carbide Gd(13)Fe(10)C(13). This compound adopts a new structure type that is remarkable for its "H"-shaped C(2)FeFeC(2) units, which have some of the shortest Fe-Fe contacts known. A bonding analysis using DFT-calibrated Hückel calculations hints that Fe-Fe multiple bonding underlies these short distances. Gd(13)Fe(10)C(13) undergoes ferromagnetic ordering at ?55 K. PMID:22676209

Hadler, Amelia B; Fredrickson, Daniel C

2012-06-27

141

Algorithms for Matrix Multiplication.  

National Technical Information Service (NTIS)

Strassen's and Winograd's algorithms for matrix multiplication are investigated and compared with the normal algorithm. Floating - point error bounds are obtained, and it is shown that scaling is essential for numerical accuracy using Winograd's method. I...

R. P. Brent

1970-01-01

142

Multiple System Atrophy  

MedlinePLUS

... Page Condensed from Multiple System Atrophy Fact Sheet Table of Contents (click to jump to sections) What ... problems, combined with motor control symptoms such as tremor, rigidity, and loss of muscle coordination. MSA affects ...

143

Cancer Following Multiple Fluoroscopies.  

National Technical Information Service (NTIS)

An epidemiological study for detecting carcinogenic effects of multiple fluoroscopies in Canadian tuberculosis patients, treated in the late 1930's to early 1950's when artificial pneumothorax was a standard procedure, is described. Intensive investigatio...

H. B. Newcombe

1975-01-01

144

MULTIPLE DIFFBRENTIAL THERMAL ANALYSIS  

Microsoft Academic Search

In this article equipment is described rvhich is designed to further increase the utility of the method. Through the use of standard recording devices in circuit with multiple units, six difierential thermal curves may be obtained simultaneously. This a\\

Paur F. KBnn aun; J. L. Kurr

145

Multiple Target Tracking Study.  

National Technical Information Service (NTIS)

A particular multiple target tracking mission was studied to determine the radar requirements. Several phased array radar configurations are described. A limited scan array is selected as the most cost effective. The phased array radar is compared with a ...

E. M. Brown D. N. Thomson

1974-01-01

146

Multiple Use of Hemodialyzers.  

National Technical Information Service (NTIS)

This project was designed to conduct studies which would yield information permitting conclusions regarding the safety and efficacy of procedures for multiple use of hemodialyzers. The procedures were tested principally in terms of the function, disinfect...

J. A. Bemis N. Deane

1981-01-01

147

Fertility Treatment and Multiples  

MedlinePLUS Videos and Cool Tools

... opportunities Advocacy in government For health professionals General health information I have personal experience with: Prematurity NICU experience Birth Defects High-risk pregnancy Loss Infertility Multiples None Of Above March ...

148

Multiple Principal Investigators  

Cancer.gov

Below is information to learn about NIH definitions, policies, and awards available to apply for support using the Multiple Principal Investigator (PI) model that supports team science. Answers to FAQs are included.

149

Multiple Thermocouple Testing Device.  

National Technical Information Service (NTIS)

This invention relates generally to a thermocouple testing device, and, more particularly, to an automated multiple thermocouple testing device that checks for short and open circuits. This device can be used to test thermocouple circuits in gas turbine e...

J. R. Hildebrand

1982-01-01

150

Photovoltaics: Separating Multiple Excitons  

SciTech Connect

Scientists have demonstrated an efficient process for generating multiple excitons in adjacent silicon nanocrystals from a single high-energy photon. Their findings could prove useful for a wide range of photovoltaic applications.

Nozik, A. J.

2012-05-01

151

Multiple Turbo Codes  

NASA Technical Reports Server (NTRS)

A description is given of multiple turbo codes and a suitable decoder structure derived from an approximation to the maximum a posteriori probability (MAP) decision rule, which is substantially different from the decoder for two-code-based encoders.

Divsalar, D.; Pollara, F.

1995-01-01

152

What Is Multiple Myeloma?  

MedlinePLUS

... Multiple myeloma is a cancer formed by malignant plasma cells. Normal plasma cells are found in the bone marrow and ... to an infection, they mature and change into plasma cells. Plasma cells make the antibodies (also called ...

153

Multiplication as Combinations  

NSDL National Science Digital Library

In this lesson plan students explore how to use multiplication to find the number of combinations possible in various situations. They follow the Cyberchase kids through two short videos as they explore creating a matrix and a tree diagram to solve the number of combinations; looking for patterns across data and leading to the conclusion that the same solutions could have been found through multiplication (counting principle). The lesson plan includes two student worksheets, two assessment options, and an answer key (rtf).

Education, Wnet O.

2006-01-01

154

Mobile multiple access study  

NASA Technical Reports Server (NTRS)

Multiple access techniques (FDMA, CDMA, TDMA) for the mobile user and attempts to identify the current best technique are discussed. Traffic loading is considered as well as voice and data modulation and spacecraft and system design. Emphasis is placed on developing mobile terminal cost estimates for the selected design. In addition, design examples are presented for the alternative techniques of multiple access in order to compare with the selected technique.

1977-01-01

155

Multiple pterygium syndrome.  

PubMed Central

The multiple pterygium syndrome is a rare autosomal recessive condition characterised by arthrogryposis multiplex congenita, pterygia of the neck, fingers, and antecubital, popliteal, and intercrural areas, growth retardation, and facial, vertebral, and genital anomalies. We present two unrelated patients of 17 and 6 years of age, respectively, affected with this condition. We describe the natural history of their disorder since birth and review the spectrum of phenotypic variation of the multiple pterygium syndrome in 25 published cases. Images

Penchaszadeh, V B; Salszberg, B

1981-01-01

156

Pyrochemical multiplicity counter development  

SciTech Connect

Impure plutonium-bearing materials from pyrochemical processes often display both significant self-multiplication and variable ({alpha},n) reaction rates. Standard neutron coincidence counting techniques usually fail to accurately measure these materials. Neutron multiplicity counters measure the third moment of the neutron multiplicity distribution and thus make it possible to deduce the fertile plutonium mass of a sample even when both the self-multiplication and the ({alpha},n) reaction rate are unknown. A multiplicity counter suitable for measuring pyrochemical materials has been designed and built. This paper describes the results of characterization studies for the new counter. The counter consists of 126 helium-3 tubes arranged in 4 concentric rings in a polyethylene moderator; the average spacing between the tubes is 1.59 cm. The end plugs for the counter are made of graphite, and the 24.1- by 37.5-cm sample cavity is cadmium lined. The counter consists of two distinct halves from which the neutron counts are summed. The counter is capable of operation in either a freestanding mode with the two halves coupled together by an external cabinet or in a glove-box mode with the two halves placed around a glovebox well and then mated. For a {sup 252}Cf source centered in the sample cavity, the measured efficiency of the new multiplicity counter is 57.7% and its die-away time is 47.2{mu}s. 8 refs., 9 figs.

Langner, D.G.; Dytlewski, N.; Krick, M.S.

1991-01-01

157

Multiple stage multiple filter hydrate store  

DOEpatents

An improved hydrate store for a metal halogen battery system is disclosed which employs a multiple stage, multiple filter means for separating the halogen hydrate from the liquid used in forming the hydrate. The filter means is constructed in the form of three separate sections which combine to substantially cover the interior surface of the store container. Exit conduit means is provided in association with the filter means for transmitting liquid passing through the filter means to a hydrate former subsystem. The hydrate former subsystem combines the halogen gas generated during the charging of the battery system with the liquid to form the hydrate in association with the store. Relief valve means is interposed in the exit conduit means for controlling the operation of the separate sections of the filter means, such that the liquid flow through the exit conduit means from each of the separate sections is controlled in a predetermined sequence. The three separate sections of the filter means operate in three discrete stages to provide a substantially uniform liquid flow to the hydrate former subsystem during the charging of the battery system. The separation of the liquid from the hydrate causes an increase in the density of the hydrate by concentrating the hydrate along the filter means. 7 figs.

Bjorkman, H.K. Jr.

1983-05-31

158

Multiple stage multiple filter hydrate store  

DOEpatents

An improved hydrate store for a metal halogen battery system is disclosed which employs a multiple stage, multiple filter means or separating the halogen hydrate from the liquid used in forming the hydrate. The filter means is constructed in the form of three separate sections which combine to substantially cover the interior surface of the store container. Exit conduit means is provided in association with the filter means for transmitting liquid passing through the filter means to a hydrate former subsystem. The hydrate former subsystem combines the halogen gas generated during the charging of the battery system with the liquid to form the hydrate in association with the store. Relief valve means is interposed in the exit conduit means for controlling the operation of the separate sections of the filter means, such that the liquid flow through the exit conduit means from each of the separate sections is controlled in a predetermined sequence. The three separate sections of the filter means operate in three discrete stages to provide a substantially uniform liquid flow to the hydrate former subsystem during the charging of the battery system. The separation of the liquid from the hydrate causes an increase in the density of the hydrate by concentrating the hydrate along the filter means.

Bjorkman, Jr., Harry K. (Birmingham, MI)

1983-05-31

159

Trousseau's syndrome: multiple definitions and multiple mechanisms  

PubMed Central

In 1865, Armand Trousseau noted that unexpected or migratory thrombophlebitis could be a forewarning of an occult visceral malignancy. An analysis by Sack and colleagues in 1977 extended the term Trousseau's syndrome to include chronic disseminated intravascular coagulopathy associated with microangiopathy, verrucous endocarditis, and arterial emboli in patients with cancer, often occurring with mucin-positive carcinomas. In recent times the term has been ascribed to various clinical situations, ranging all the way from these classic descriptions to any kind of coagulopathy occurring in the setting of any kind of malignancy. These multiple definitions of Trousseau's syndrome are partly the consequence of multiple pathophysiologic mechanisms that apparently contribute to the hypercoagulability associated with cancer. Even the classic syndrome probably represents a spectrum of disorders, ranging from exaggerated fluid-phased thrombosis dependent on prothrombotic agents such as tissue factor to a platelet- and endotheliumum-based selectin-dependent microangiopathy associated with mucin-producing carcinomas, along with thrombin and fibrin production. Also considered here are recent hypotheses about genetic pathways within tumor cells that might trigger these thrombotic phenomena, and the reasons why therapy with heparins of various kinds remain the preferred treatment, probably because of their salutary actions on several of the proposed pathologic mechanisms.

2007-01-01

160

Optical-biophysical relationships and validation of MODIS vegetation indices with multiple fine spatial resolution data in semiarid rangelands  

NASA Astrophysics Data System (ADS)

The vegetation index products from the Moderate Resolution Imaging Spectroradiometer (MODIS) are designed to provide consistent, spatial and temporal comparisons of global vegetation conditions. The objective of this dissertation was to validate the robustness and global implementation of two MODIS VI algorithms, including the normalized difference vegetation index (NDVI) and "enhanced" vegetation index (EVI). Their performances have been evaluated in: (1) the normalization of canopy background (brightness) variations and the extraction of biophysical parameters across different canopy structures; (2) the characterization of seasonal vegetation profiles (phenological, intra-annual); and (3) spatial and temporal discrimination of vegetation differences (inter-annual). The validation was accomplished through multiple means, including canopy radiative transfer models which were utilized to extract pure vegetation spectra and "true" VI value free of background contamination for varying canopy structures and vegetation amount. The experimental field- and airborne-based radiometry and satellite imagery at multiple spatial resolutions were also coupled and scaled-up for comparison with coarse spatial resolution MODIS VI products to quantify characteristics of semiarid rangeland vegetation. The results showed that NDVI was advantageous in yielding biophysical relationships applicable across varying canopy types, but required knowledge of soils for biophysical estimations. The EVI provided biophysical relationships sensitive to canopy structure, thus requiring knowledge of canopy type for biophysical assessments. The MODIS VI products were successfully validated, radiometrically, by coupling field and the MODLAND Quick Airborne Looks (MQUALS) observations to high spatial resolution imagery (AVIRIS and ETM+), and appeared robust across the two parallel sites for depicting their ecological equivalents. MODIS multitemporal VI profiles were able to depict phenological activity, length of the growing season, peak and onset of greenness, and leaf turnover. Among the sensors tested, spatial resolution was found to be most important for discriminating the major land cover subtypes within the two parallel semiarid rangelands, and spectral resolution had major effects on capturing seasonal contrast due to atmosphere influences. The validation strategy utilized in this study to successively aggregate the integrity-inherent multiple fine spatial resolution data to the coarse MODIS pixel sizes appeared to perform well, thus showing potentials in the validation of other satellite products.

Gao, Xiang

161

Multiple Determinations of Sperm DNA Fragmentation Show That Varicocelectomy Is Not Indicated for Infertile Patients with Subclinical Varicocele  

PubMed Central

Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient's fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA) were performed on semen samples from sixty infertile patients with varicocele (15 clinical varicoceles, 19 clinical varicoceles after surgical treatment, 16 subclinical varicoceles, and 10 subclinical varicoceles after surgical treatment). TUNEL, SCD, and SCSA assays all showed substantial sperm DNA fragmentation levels that were comparable between subclinical and clinical varicocele patients. Importantly, varicocelectomy did improve sperm quality in patients with clinical varicocele; however, this was not the case in patients with subclinical varicocele. In summary, although infertile patients with clinical and subclinical varicocele have similar sperm DNA quality, varicocelectomy should only be advised for patients with clinical varicocele.

Garcia-Peiro, Agustin; Ribas-Maynou, Jordi; Oliver-Bonet, Maria; Navarro, Joaquima; Checa, Miguel A.; Nikolaou, Alexandros; Amengual, Maria J.; Abad, Carlos; Benet, Jordi

2014-01-01

162

Multiple determinations of sperm DNA fragmentation show that varicocelectomy is not indicated for infertile patients with subclinical varicocele.  

PubMed

Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient's fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA) were performed on semen samples from sixty infertile patients with varicocele (15 clinical varicoceles, 19 clinical varicoceles after surgical treatment, 16 subclinical varicoceles, and 10 subclinical varicoceles after surgical treatment). TUNEL, SCD, and SCSA assays all showed substantial sperm DNA fragmentation levels that were comparable between subclinical and clinical varicocele patients. Importantly, varicocelectomy did improve sperm quality in patients with clinical varicocele; however, this was not the case in patients with subclinical varicocele. In summary, although infertile patients with clinical and subclinical varicocele have similar sperm DNA quality, varicocelectomy should only be advised for patients with clinical varicocele. PMID:24967335

García-Peiró, Agustín; Ribas-Maynou, Jordi; Oliver-Bonet, María; Navarro, Joaquima; Checa, Miguel A; Nikolaou, Alexandros; Amengual, María J; Abad, Carlos; Benet, Jordi

2014-01-01

163

Multiple Intelligences and Business Diversity.  

ERIC Educational Resources Information Center

Results from 97 business students with substantial work histories indicate that the Multiple Intelligence Preference Inventory gives a valid and reliable indication of their preferred intelligences. Awareness of these results is associated with assessments of self and others as knowledge sources. This information can help in recognizing,…

Martin, Joyce

2003-01-01

164

STP Multiplicative Process Program  

NSDL National Science Digital Library

The STP Multiplicative Process program simulates the outcome of a random multiplicative process, a product of random numbers. Examples of multiplicative processes include the distributions of incomes, rainfall, and the fragments sizes in rock crushing processes. Consider the latter for which we begin with a rock of size w. We strike the rock with a hammer and generate two fragments whose sizes are pw and (1-p)w. What is the distribution of the fragments after N blows of the hammer? The default is the random product of two numbers x1 and x2 with probability p = 1/2 multiplied N=4 times. STP MultiplicativeProcess is part of a suite of Open Source Physics programs that model aspects of Statistical and Thermal Physics (STP). The program is distributed as a ready-to-run (compiled) Java archive. Double clicking the stp_MultiplicativeProcess.jar file will run the program if Java is installed on your computer. Additional programs can be found by searching ComPADRE for Open Source Physics, STP, or Statistical and Thermal Physics.

Gould, Harvey; Tobochnik, Jan; Christian, Wolfgang; Cox, Anne

2009-03-09

165

Multiple Adenomatous Duodenal Polyposis  

PubMed Central

Multiple duodenal polyps are a relatively rare finding, usually co-occurrent with familial adenomatous polyposis (FAP).We report a patient with multiple duodenal adenomas and a negative examination for FAP: multiple flat polyps were detected endoscopically in a 37-year-old male patient, extending from the apex of the bulb to the end of the descending part of the duodenum. In terms of histology, they were tubular adenomas with moderate dysplasia. Colonoscopy and enteroclysis were normal. Both push and capsule enteroscopy only showed multiple polyps in the area of the descending duodenum. DNA analysis of the APC gene was as follows: DGGE, exon 1–15, deletion at codons 1309 and 1061 by means of PCR for attenuated APC were negative. Afterwards we screened the patient for germline MYH mutations using the denaturing high-performance liquid chromatography (DHPLC) in combination with sequencing. No novel pathogenic mutation has been identified. Large polyps were removed by means of endoscopic polypectomy and mucosectomy, while small polyps were removed by means of argon plasma coagulation.We conduct yearly checkups, removing only sporadic polyps. The rare finding of duodenal polyposis not co-occurrent with FAP proves that multiple adenomas in the digestive tube need not necessarily co-occur with FAP.

Zadorova, Zdena; Mandys, Vaclav

2013-01-01

166

Carrier multiplication in graphene.  

PubMed

Graphene as a zero-bandgap semiconductor is an ideal model structure to study the carrier relaxation channels, which are inefficient in conventional semiconductors. In particular, it is of fundamental interest to address the question whether Auger-type processes significantly influence the carrier dynamics in graphene. These scattering channels bridge the valence and conduction band allowing carrier multiplication, a process that generates multiple charge carriers from the absorption of a single photon. This has been suggested in literature for improving the efficiency of solar cells. Here we show, based on microscopic calculations within the density matrix formalism, that Auger processes do play an unusually strong role for the relaxation dynamics of photoexcited charge carriers in graphene. We predict that a considerable carrier multiplication takes place, confirming the potential of graphene as a new material for high-efficiency photodevices. PMID:21053963

Winzer, Torben; Knorr, Andreas; Malic, Ermin

2010-12-01

167

Neutron multiplicity counter development  

SciTech Connect

We have designed and built two multiplicity counters to test the usefulness of multiplicity counting for the safeguards assay of plutonium-bearing materials. The first prototype counter has been characterized and a variety of plutonium-bearing materials have been measured with it. Assays accurate to {approximately}0.7% have been obtained for both pure and impure plutonium oxide samples in reasonable measurement times. Assays accurate to {approximately}5% have been obtained for metal samples. A second multiplicity counter has been designed using experience gained from the first as well as Monte Carlo simulations. The second counter was designed to be more suitable for in-plant measurement of pyrochemical process materials. This paper presents the results of characterization studies of the two instruments. 10 refs., 9 figs., 2 tabs.

Langner, D.G.; Krick, M.S.; Ensslin, N.; Bosler, G.E.; Dytlewski, N.

1991-01-01

168

Factor-multiple Chains  

NSDL National Science Digital Library

This problem offers opportunities for students to reinforce their understanding of factors and multiples and provides them the chance to justify their solutions. The goal is for the students to create number chains of four whole numbers that can range from 2 to 100 and each consecutive number is a multiple of the previous number. The Teachers' Notes page offers suggestions for implementation, key discussion questions, ideas for extension and support, and a link to a spreadsheet for students to experiment with placing numbers in specific boxes in the chain.

2007-04-01

169

Neutron multiplicity analysis tool  

SciTech Connect

I describe the capabilities of the EXCOM (EXcel based COincidence and Multiplicity) calculation tool which is used to analyze experimental data or simulated neutron multiplicity data. The input to the program is the count-rate data (including the multiplicity distribution) for a measurement, the isotopic composition of the sample and relevant dates. The program carries out deadtime correction and background subtraction and then performs a number of analyses. These are: passive calibration curve, known alpha and multiplicity analysis. The latter is done with both the point model and with the weighted point model. In the current application EXCOM carries out the rapid analysis of Monte Carlo calculated quantities and allows the user to determine the magnitude of sample perturbations that lead to systematic errors. Neutron multiplicity counting is an assay method used in the analysis of plutonium for safeguards applications. It is widely used in nuclear material accountancy by international (IAEA) and national inspectors. The method uses the measurement of the correlations in a pulse train to extract information on the spontaneous fission rate in the presence of neutrons from ({alpha},n) reactions and induced fission. The measurement is relatively simple to perform and gives results very quickly ({le} 1 hour). By contrast, destructive analysis techniques are extremely costly and time consuming (several days). By improving the achievable accuracy of neutron multiplicity counting, a nondestructive analysis technique, it could be possible to reduce the use of destructive analysis measurements required in safeguards applications. The accuracy of a neutron multiplicity measurement can be affected by a number of variables such as density, isotopic composition, chemical composition and moisture in the material. In order to determine the magnitude of these effects on the measured plutonium mass a calculational tool, EXCOM, has been produced using VBA within Excel. This program was developed to help speed the analysis of Monte Carlo neutron transport simulation (MCNP) data, and only requires the count-rate data to calculate the mass of material using INCC's analysis methods instead of the full neutron multiplicity distribution required to run analysis in INCC. This paper describes what is implemented within EXCOM, including the methods used, how the program corrects for deadtime, and how uncertainty is calculated. This paper also describes how to use EXCOM within Excel.

Stewart, Scott L [Los Alamos National Laboratory

2010-01-01

170

4.OA Identifying Multiples  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: Below is a multiplication table for single digit numbers: Use a different copy of the multiplication table for each of the questions below: Color all b...

171

Multiple sort flow cytometer  

DOEpatents

A flow cytometer utilizes multiple lasers for excitation and respective fluorescence of identified dyes bonded to specific cells or events to identify and verify multiple events to be sorted from a sheath flow and droplet stream. Once identified, verified and timed in the sheath flow, each event is independently tagged upon separation from the flow by an electrical charge of +60, +120, or +180 volts and passed through oppositely charged deflection plates with ground planes to yield a focused six way deflection of at least six events in a narrow plane. 8 figs.

Engh, G. van den; Esposito, R.J.

1996-01-09

172

Multiple sort flow cytometer  

DOEpatents

A flow cytometer utilizes multiple lasers for excitation and respective fluorescence of identified dyes bonded to specific cells or events to identify and verify multiple events to be sorted from a sheath flow and droplet stream. Once identified, verified and timed in the sheath flow, each event is independently tagged upon separation from the flow by an electrical charge of +60, +120, or +180 volts and passed through oppositely charged deflection plates with ground planes to yield a focused six way deflection of at least six events in a narrow plane.

Van den Engh, Ger (Seattle, WA); Esposito, Richard J. (Seattle, WA)

1996-01-01

173

Evolution of multiple sex chromosomes in the spider genus Malthonica (Araneae: Agelenidae) indicates unique structure of the spider sex chromosome systems.  

PubMed

Most spiders exhibit a multiple sex chromosome system, X(1)X(2)0, whose origin has not been satisfactorily explained. Examination of the sex chromosome systems in the spider genus Malthonica (Agelenidae) revealed considerable diversity in sex chromosome constitution within this group. Besides modes X(1)X(2)0 (M. silvestris) and X(1)X(2)X(3)0 (M. campestris), a neo-X(1)X(2)X(3)X(4)X(5)Y system in M. ferruginea was found. Ultrastructural analysis of spread pachytene spermatocytes revealed that the X(1)X(2)0 and X(1)X(2)X(3)0 systems include a pair of homomorphic sex chromosomes. Multiple X chromosomes and the pair exhibit an end-to-end pairing, being connected by attachment plaques. The X(1)X(2)X(3)X(4)X(5)Y system of M. ferruginea arose by rearrangement between the homomorphic sex chromosome pair and an autosome. Multiple X chromosomes and the sex chromosome pair do not differ from autosomes in a pattern of constitutive heterochromatin. Ultrastructural data on sex chromosome pairing in other spiders indicate that the homomorphic sex chromosome pair forms an integral part of the spider sex chromosome systems. It is suggested that this pair represents ancestral sex chromosomes of spiders, which generated multiple X chromosomes by non-disjunctions. Structural differentiation of newly formed X chromosomes has been facilitated by heterochromatinization of sex chromosome bivalents observed in prophase I of spider females. PMID:17899407

Král, Jirí

2007-01-01

174

Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma  

PubMed Central

In this study, we show that the hyaluronan synthase 1 (HAS1) gene undergoes aberrant intronic splicing in multiple myeloma (MM). In addition to HAS1 full length (HAS1FL), we identify 3 novel splice variants of HAS1, HAS1Va, HAS1Vb, and HAS1Vc, detected in patients with MM or monoclonal gammopathy of undetermined significance (MGUS). HAS1Vb and HAS1Vc undergo intronic splicing with creation of a premature stop codon. MM cells expressing one or more HAS1 variants synthesize extracellular and/or intracellular hyaluronan (HA). Expression of the HAS1Vb splice variant was significantly correlated with reduced survival (P = .001). Together, alternative HAS1 gene splicing, the correlations between HAS1 splicing and HA synthesis, and the correlations between HAS1 splicing and reduced survival of MM patients support the hypothesis that the family of HAS1 protein plays a significant role in disease progression. Further, expression of HAS1Vb, in conjunction with HAS1FL and/or other HAS1 variants, may lead to accumulation of intracellular HA molecules and an impact on receptor for HA-mediated motility (RHAMM)-mediated mitotic abnormalities in MM. This study highlights the potential importance of HAS1 and its alternative splicing in pathophysiology of MGUS and MM. (Blood. 2005;105: 4836-4844)

Adamia, Sophia; Reiman, Tony; Crainie, Mary; Mant, Michael J.; Belch, Andrew R.; Pilarski, Linda M.

2005-01-01

175

Indices of cognitive dysfunction in relapsing-remitting multiple sclerosis: intra-individual variability, processing speed, and attention network efficiency.  

PubMed

Impairments in attention and information processing speed are common in multiple sclerosis (MS) and may contribute to impairments of other cognitive abilities. This study examined attentional efficiency, information processing speed and intra-individual variability in response speed using the Attention Network Test-Interactions (ANT-I) in mildy-affected patients with MS. Thirty-one patients with relapsing-remitting MS and 30 age, sex, and education-matched controls completed the ANT-I, as well as the Paced Auditory Serial Attention Test (PASAT), as a standard clinical measure of information processing efficiency. As expected, patients with MS were slower in reaction time performance on the ANT-I and had poorer performance on the PASAT compared to controls. Patients with MS also demonstrated poorer efficiency in their executive control of attention on the ANT-I, suggesting difficulties with top-down allocation of attention. In addition, the MS group demonstrated greater intra-individual variability in the responses to the ANT-I even when their slower overall response time and other factors such as practice were accounted for. Intra-individual variability was found to best predict group membership compared to PASAT scores and other ANT-I scores. These results suggest that intra-individual variability may provide sensitive, unique and important information regarding cognitive functioning in early MS. PMID:23425598

Wojtowicz, Magdalena; Omisade, Antonina; Fisk, John D

2013-05-01

176

Multiple Sclerosis Foundation  

MedlinePLUS

MSF News Audio Available from MS Research Update Teleconference 6/18/2014 Online Radio Station for MS is First of its Kind 6/11/2014 Brighter Tomorrow ... Mulligans 12 Weeks of Summer to Benefit the Multiple Sclerosis Foundation! in Lauderdale by the Sea & Lake Worth , ...

177

Multiple Grammars and MOGUL  

ERIC Educational Resources Information Center

Optionality is a central phenomenon in second language acquisition (SLA), for which any adequate theory must account. Amaral and Roeper (this issue; henceforth A&R) offer an appealing approach to it, using Roeper's Multiple Grammars Theory, which was created with first language in mind but which extends very naturally to SLA. They include…

Truscott, John

2014-01-01

178

Multiple Beam Atomic Interferometer  

Microsoft Academic Search

We have demonstrated a multiple beam atom interferometer. Atoms in a cesium atomic beam are optically pumped into a spatially separating nonabsorbing superposition state consisting of five partial beams in different Zeeman sublevels separated by a momentum of two photon recoils each. When the partial waves are spatially recombined, we observe an interference signal which shows the sharply peaked Airy

M. Weitz; T. Heupel; T. W. Hänsch

1996-01-01

179

Automated multiple failure FMEA  

Microsoft Academic Search

Failure mode and effects analysis (FMEA) is typically performed by a team of engineers working together. In general, they will only consider single point failures in a system. Consideration of all possible combinations of failures is impractical for all but the simplest example systems. Even if the task of producing the FMEA report for the full multiple failure scenario were

C. J. Price; N. S. Taylor

2002-01-01

180

Multiple Intelligences: A Collection.  

ERIC Educational Resources Information Center

As a concise resource for Howard Gardner's theory of multiple intelligences and its implications for schooling around the world, this collection is designed for educators, parents, and others interested in education. The first section discusses Gardner and his background, and the second section expounds his theory. The third section explores the…

Fogarty, Robin, Ed.; Bellanca, James, Ed.

181

Treatment for multiple sclerosis  

US Patent & Trademark Office Database

Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.

2013-03-19

182

Concurrent multiple target tracking  

Microsoft Academic Search

A concurrent algorithm for multiple target tracking is presented. The underlying tracking formalism is first described by way of a sequential program, and the issues in generalizing the tracker for efficient concurrent implementations are discussed in detail. Typical tracking results on the Mark III hypercube are presented.

Thomas D. Gottschalk

1988-01-01

183

Wideband multiple target tracking  

Microsoft Academic Search

We propose a new scheme involving autoregressive parameter estimation and pattern classification with maximum likelihood (ML) direction of arrival (DOA) estimation to track multiple targets moving in the far-field. The targets are sources of wideband signals which impinge on a uniform linear array of passive sensors. These wideband signals are modeled as vector autoregressive (AR) models so that the spectral

A. Satish; Ratagasard L. Kashyap

1994-01-01

184

Multiple Docking Adapter Illustration  

NASA Technical Reports Server (NTRS)

This cutaway drawing details the major characteristics of the Skylab Multiple Docking Adapter (MDA). The MDA, built under the direction of the Marshall Space Flight Center, housed the control units for the Apollo Telescope Mount (ATM), Earth Resources Experiment Package (EREP), and Zero-Gravity Materials Processing Facility, and provided a docking port for the Apollo Command Module (CM).

1972-01-01

185

Unfolding Fraction Multiplication  

ERIC Educational Resources Information Center

Students often have difficulty understanding fractions, in general, and understanding how to multiply fractions, in particular. To move past this potential problem area, students need to develop a deeper understanding of multiplication and connect the ideas to fractions. In this article, the authors share their insights into teaching fraction…

Wyberg, Terry; Whitney, Stephanie R.; Cramer, Kathleen A.; Monson, Debra S.; Leavitt, Seth

2011-01-01

186

Multiple Slit Diffraction Model  

NSDL National Science Digital Library

The EJS Multiple Slit Diffraction model allows the user to simulate Fraunhofer diffraction through single or multiple slits. The user can modify the number of slits, the slit width, the slit separation and the wavelength of the incident light. The scale of the diffraction pattern can also be changed and a plot of the light intensity can be toggled on and off with a checkbox. A basic theoretical introduction to diffraction is included. The Multiple Slit Diffraction Model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_ntnu_optics_MultipleSlitDiffraction.jar file will run the program if Java is installed. Ejs is a part of the Open Source Physics Project and is designed to make it easier to access, modify, and generate computer models. Additional Open Source Physics programs for quantum mechanics are available. They can be found by searching ComPADRE for Open Source Physics, OSP, or EJS.

Hwang, Fu-Kwun

2008-11-22

187

Factors and Multiples Puzzle  

NSDL National Science Digital Library

This puzzle provides an interesting context which challenges learners to apply their knowledge of the properties of numbers. Learners need to work with various types of numbers at the same time and consider their relationships to each other (e.g. primes, squares and specific sets of multiples).

Nrich

2007-01-01

188

Multiple access trade study  

NASA Technical Reports Server (NTRS)

The Personal Access Satellite System (PASS) strawman design uses a hybrid Time Division Multiple Access (TDMA)/Frequency Division Multiple Access (FDMA) implementation. TDMA is used for the forward direction (from Suppliers to Users), and FDMA for the return direction (from Users to Suppliers). An alternative architecture is proposed that will require minimal real time coordination and yet provide a fast access method by using random access Code Division Multiple Access (CDMA). The CDMA system issues are addressed such as connecting suppliers and users, both of whom may be located anywhere in the CONUS, when the user terminals are constrained in size and weight; and providing efficient traffic routing under highly variable traffic requirements. It is assumed that bandwidth efficiency is not of paramount importance. CDMA or Spread Spectrum Multiple Access (SSMA) communication is a method in which a group of carriers operate at the same nominal center frequency but are separable from each other by the low cross correlation of the spreading codes used. Interference and multipath rejection capability, ease of selective addressing and message screening, low density power spectra for signal hiding and security, and high resolution ranging are among the benefits of spread spectrum communications.

Motamedi, Masoud

1990-01-01

189

Gini's Multiple Regressions  

Microsoft Academic Search

Two regression methods can be interpreted as based on Gini's mean difference (GMD). One relies on a weighted average of slopes defined between adjacent observations and the other is based on minimization of the GMD of the errors. The properties of the former approach are investigated in a multiple regression framework. These estimators have representations that resemble the OLS estimators,

Edna Schechtman; Shlomo Yitzhaki

190

Immunopathogenesis of multiple sclerosis  

Microsoft Academic Search

Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by autoimmune inflammation, demyelination, and axonal damage. MS etiology remains unknown, but disease phenotype is most likely the result of an interaction between complex genetic factors and environmental influences. The better understanding of the mechanisms involved in the immunopathogenesis of MS has led to the development of

Manuel Comabella; Samia J. Khoury

191

IMMUNOLOGY OF MULTIPLE SCLEROSIS  

Microsoft Academic Search

Ke yW ords autoimmunity, autoimmune mechanisms, neuroimmunology, demyelinating dieseases, EAE ? Abstract Multiple sclerosis (MS) develops in young adults with a complex pre- disposing genetic trait and probably requires an inciting environmental insult such as a viral infection to trigger the disease. The activation of CD4+ autoreactive T cells and their differentiation into a Th1 phenotype is a crucial event

Mireia Sospedra; Roland Martin

2005-01-01

192

Automatic multiple applicator electrophoresis  

NASA Technical Reports Server (NTRS)

Easy-to-use, economical device permits electrophoresis on all known supporting media. System includes automatic multiple-sample applicator, sample holder, and electrophoresis apparatus. System has potential applicability to fields of taxonomy, immunology, and genetics. Apparatus is also used for electrofocusing.

Grunbaum, B. W.

1977-01-01

193

Managing advanced multiple sclerosis.  

PubMed Central

Multiple sclerosis is one of the most common neurologic conditions in Canada. Many individuals with MS eventually develop the progressive form of the disease. The neurologic and psychosocial manifestations of the later stages of MS are numerous. Family physicians ought to have some understanding of patients with advanced MS and some knowledge of how to manage them.

Teasell, R. W.

1993-01-01

194

Mastering the Multiplication Facts  

ERIC Educational Resources Information Center

The purpose of this paper is to share the results of a six-week research project (after baseline data was collected) that focused on three different strategies (flashcards, interactive games, and music) and their effectiveness in helping fifth grade students memorize the basic multiplication facts. Many teachers face a serious problem when their…

D'Ettorre, Jenna

2009-01-01

195

10monkeys Multiplication  

NSDL National Science Digital Library

This iOS app provides practice with multiplication facts in an arcade-like format. Students choose from among 10 levels (2 to 10 times tables and mixed times tables) and identify products of given factors in order to free trapped monkeys. Scoring rewards both accuracy and speed.

2013-07-03

196

Viruses and Multiple Sclerosis  

PubMed Central

Multiple sclerosis (MS) is a chronic demyelinating disorder of unknown etiology, possibly caused by a virus or virus-triggered immunopathology. The virus might reactivate after years of latency and lyse oligodendrocytes, as in progressive multifocal leukoencephalopathy, or initiate immunopathological demyelination, as in animals infected with Theiler’s murine encephalomyelitis virus or coronaviruses. The argument for a viral cause of MS is supported by epidemiological analyses and studies of MS in identical twins, indicating that disease is acquired. However, the most important evidence is the presence of bands of oligoclonal IgG (OCBs) in MS brain and CSF that persist throughout the lifetime of the patient. OCBs are found almost exclusively in infectious CNS disorders, and antigenic targets of OCBs represent the agent that causes disease. Here, the authors review past attempts to identify an infectious agent in MS brain cells and discuss the promise of using recombinant antibodies generated from clonally expanded plasma cells in brain and CSF to identify disease-relevant antigens. They show how this strategy has been used successfully to analyze antigen specificity in subacute sclerosing panencephalitis, a chronic encephalitis caused by measles virus, and in neuromyelitis optica, a chronic autoimmune demyelinating disease produced by antibodies directed against the aquaporin-4 water channel.

Owens, Gregory P.; Gilden, Don; Burgoon, Mark P.; Yu, Xiaoli; Bennett, Jeffrey L.

2012-01-01

197

Viruses and multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is a chronic demyelinating disorder of unknown etiology, possibly caused by a virus or virus-triggered immunopathology. The virus might reactivate after years of latency and lyse oligodendrocytes, as in progressive multifocal leukoencephalopathy, or initiate immunopathological demyelination, as in animals infected with Theiler's murine encephalomyelitis virus or coronaviruses. The argument for a viral cause of MS is supported by epidemiological analyses and studies of MS in identical twins, indicating that disease is acquired. However, the most important evidence is the presence of bands of oligoclonal IgG (OCBs) in MS brain and CSF that persist throughout the lifetime of the patient. OCBs are found almost exclusively in infectious CNS disorders, and antigenic targets of OCBs represent the agent that causes disease. Here, the authors review past attempts to identify an infectious agent in MS brain cells and discuss the promise of using recombinant antibodies generated from clonally expanded plasma cells in brain and CSF to identify disease-relevant antigens. They show how this strategy has been used successfully to analyze antigen specificity in subacute sclerosing panencephalitis, a chronic encephalitis caused by measles virus, and in neuromyelitis optica, a chronic autoimmune demyelinating disease produced by antibodies directed against the aquaporin-4 water channel. PMID:22130640

Owens, Gregory P; Gilden, Don; Burgoon, Mark P; Yu, Xiaoli; Bennett, Jeffrey L

2011-12-01

198

Multiple Dural Arteriovenous Fistulas  

PubMed Central

Summary Dural arteriovenous fistulas are most probably acquired lesions. However, they have been rarely encountered de novo. We present a unique case of a 71-year-old woman who initially presented with right-sided dural arteriovenous fistula (DAVF), which spontaneously resolved after diagnostic arteriography. She later developed asymptomatic occlusion of the left transverse sinus. Five years after her initial presentation she developed left-sided pulse-synchronous tinnitus. MRA and catheter angiography showed a complex type IV DAVF between the left transverse sinus and multiple dural branches arising from both left and right external carotid arteries. The left transverse sinus was isolated from the torcula herophili, with stenosis of the sigmoid sinus. Extensive cortical venous drainage was demonstrated. Endovascular cure was effected by polyvinyl alcohol particle and absolute alcohol occlusion of the dominant dural supply, and transvenous coil occlusion of the left transverse sinus. The patient's symptoms resolved almost immediately. This unique case demonstrates that dural sinus occlusion and DAVFs may co-exist, but there may not be a causal relationship. It is likely that both DAVFs and sinus occlusion are manifestations of the same disease process characterised by a pro-thrombotic state and secondary angiogenesis. It is important to recognise that changes in symptomatology, even long after apparent disappearance of a lesion may indicate recurrence, and careful follow up is advocated.

Goddard, A.J.P.; Khangure, M.S.

2002-01-01

199

Regression analysis of indicating multiple incremental cost-effectiveness ratios for non-small cell lung cancer treatment.  

PubMed

Abstract Objectives: The value of a health technology can be measured in terms of cost and benefit on two-dimensional co-ordinates. This study is to quantitatively analyze the correlation and to conduct a regression on the X-Y plane constituted by cost and QALYs (quality-adjusted life years) associated with the first line treatment, the maintenance treatment, and the second line treatment for non-small cell lung cancer (NSCLC). Methods: The cost-effectiveness data of the cost and QALYs were extracted, with respect to the three categories of the NSCLC treatment, from the CEA Registry at Tufts Medical Center, regarding the literature published from 2000-2011. As a result, 44 QALY-cost ratios were identified. Results: Based on those extracted data, the correlation and regression analyses were performed by mathematical model using log and square-root functions. The plotted ratios stratified by the three stages for the NSCLC treatment were visually grouped into three clusters. There were statistically significant differences among the correlation coefficients of the cluster. In regression, the log model was found to be better fitted than the square-root model; formulating QALY?=?-1.12?+?0.16 log(Cost), -1.99?+?0.28 log(Cost), and -0.69?+?0.10 log(Cost) for the first line, the maintenance, and the second line treatment, respectively. Monetary units were standardized to 2008 US dollars. Conclusion: A good methodological potential was confirmed so as to assess the Incremental Cost Effectiveness Ratio (ICER) variations, considering stratification by multiple factors such as disease and treatment categories. This study has certain limitations, such as the small number of included articles and the stratification, not reflecting a factor of new genetic findings. PMID:24826807

Nakahara, Naohiro; Kamae, Isao

2014-08-01

200

Long-term Effects of the Family Bereavement Program on Multiple Indicators of Grief in Parentally Bereaved Children and Adolescents  

PubMed Central

Objectives This paper reports on results from a randomized experimental trial of the effects of the Family Bereavement Program (FBP) on multiple measures of grief experienced by parentally-bereaved children and adolescents over a six year period of time. Method Participants were 244 youth (ages 8–16, mean age = 11.4 years) from 156 families that had experienced the death of a parent. The sample consisted of 53% boys; ethnicity was 67% non-Hispanic white and 33% ethnic minority. Families were randomly assigned to the FBP (N=135) or a literature control condition (N=109). Two grief measures, the Texas Revised Inventory of Grief (TRIG) and the Intrusive Grief Thoughts Scale (IGTS) were administered at four times over six years, pre-test, post-test, eleven-month and six-year follow-ups. A third measure, an adaptation of the Inventory of Traumatic Grief (ITG) was administered only at the six-year follow-up. Results The FBP showed a greater reduction as compared to controls in their level of problematic grief (IGTS) at post-test and six-year follow-up and in the percent at clinical levels of problematic grief at the post-test. The FBP also reduced scores on a dimension of the ITG, Social Detachment/Insecurity, at six-year follow-up for three subgroups; those who experienced lower levels of grief at program entry, older youth, and boys. Conclusion These are the first findings from a randomized trial with long-term follow-up of the effects of a program to reduce problematic levels of grief of parentally-bereaved youth.

Sandler, Irwin N.; Ma, Yue; Tein, Jenn-Yun; Ayers, Tim S.; Wolchik, Sharlene; Kennedy, Cara L.; Millsap, Roger

2009-01-01

201

Multiple WH-Fronting Constructions.  

ERIC Educational Resources Information Center

The unique position of WH words in Slavic languages is discussed, with specific reference to Bulgarian and Serbo-Croatian. The multiple fronting characteristics of Bulgarian and Serbo-Croatian differ in terms of the following positions and behaviors: extraction from embedded questions; clitic placement and other indications of constituent status;…

Rudin, Catherine

202

Multiple myeloma: evaluation by CT  

SciTech Connect

Although patients who have multiple myeloma usually have straightforward clinical symptoms and corroborative radiographs, in some instances, these patients will present atypically, with symptoms suggesting active disease but radiographs that are normal or nonspecific. The authors reviewed the records of 32 patients who had documented multiple myeloma and had undergone CT examinations, assessing the value of those examinations. Although CT is not indicated in all patients who have multiple myeloma, it is especially useful in patients who have bone pain and normal or nonspecific radiographs. CT provided confirmatory information in all cases in which lesions were seen on radiographs. CT also frequently demonstrated a greater extent of disease than could be appreciated on the radiographs.

Schreiman, J.S.; McLeod, R.A.; Kyle, R.A.; Beabout, J.W.

1985-02-01

203

Portable multiplicity counter  

DOEpatents

A portable multiplicity counter has signal input circuitry, processing circuitry and a user/computer interface disposed in a housing. The processing circuitry, which can comprise a microcontroller integrated circuit operably coupled to shift register circuitry implemented in a field programmable gate array, is configured to be operable via the user/computer interface to count input signal pluses receivable at said signal input circuitry and record time correlations thereof in a total counting mode, coincidence counting mode and/or a multiplicity counting mode. The user/computer interface can be for example an LCD display/keypad and/or a USB interface. The counter can include a battery pack for powering the counter and low/high voltage power supplies for biasing external detectors so that the counter can be configured as a hand-held device for counting neutron events.

Newell, Matthew R. (Los Alamos, NM) [Los Alamos, NM; Jones, David Carl (Los Alamos, NM) [Los Alamos, NM

2009-09-01

204

Multiple zeros of polynomials  

NASA Technical Reports Server (NTRS)

For polynomials of higher degree, iterative numerical methods must be used. Four iterative methods are presented for approximating the zeros of a polynomial using a digital computer. Newton's method and Muller's method are two well known iterative methods which are presented. They extract the zeros of a polynomial by generating a sequence of approximations converging to each zero. However, both of these methods are very unstable when used on a polynomial which has multiple zeros. That is, either they fail to converge to some or all of the zeros, or they converge to very bad approximations of the polynomial's zeros. This material introduces two new methods, the greatest common divisor (G.C.D.) method and the repeated greatest common divisor (repeated G.C.D.) method, which are superior methods for numerically approximating the zeros of a polynomial having multiple zeros. These methods were programmed in FORTRAN 4 and comparisons in time and accuracy are given.

Wood, C. A.

1974-01-01

205

[Multiple food allergy].  

PubMed

Multiple food allergy is an adverse immune response to more than one food. When a child is allergic to a great number of foods, the clinical picture can be serious and the eviction of the implied allergens leads to important dietary restrictions. We describe the case of a 4-year-old child with serious atopic eczema and multiple food allergy. At 8 months she presented positive specific Imunoglobulin (Ig)E for milk, wheat, rye, barley, gluten, soy, egg (yolk and white) and initiated eviction of these foods. At 20 months she tried to introduce wheat but suspended after aggravation of atopic eczema. At 3 years old, she had anaphylaxis after contact with cheese. At 4 years old she keeps eviction of milk, egg, wheat, gluten, barley and rye. Food restrictions in these patients are high, demanding a rigorous control of foods ingested to prevent both adverse reactions and nutricional deficits. Multidisciplinary approach is important. PMID:22015034

Pinheiro, Adriana; Prates, Sara

2011-01-01

206

Multiple Stressors and Disturbances  

Microsoft Academic Search

\\u000a Marine communities are increasingly affected by numerous stressors that act as agents of physical and biological disturbance\\u000a through a combination of natural and human-induced impacts. These include storms, sedimentation, temperature changes, pollution,\\u000a eutrophication, over-harvesting, damage to habitats, arrival of invasive species and climate change. Here I discuss how multiple\\u000a stressors alter assemblages on rocky reefs through direct impacts on organisms

David R. Schiel

207

Fulminant multiple sclerosis (MS)  

Microsoft Academic Search

Fulminant multiple sclerosis (MS) is the most malignant form of MS which usually leads to death in few weeks. Although it\\u000a can be accompanied by optic neuritis (ON), but long interval between ON and the grave onset has not been reported. Fulminant\\u000a MS usually occurs as the first onset and previous ON is not common. We report a rare case

Mohammad Rohani; Shadi Ghourchian

208

Multiple Osteolytic Lesions  

PubMed Central

Several systemic diseases initially present with various oral manifestations. Investigation of these oral symptoms may at times lead to the diagnosis of grave underlying life-threatening conditions. We present one such case, where the patient manifested with gross enlargement of the mandible, along with lesions in the lower limbs. These lesions were the initial manifestation and on further investigations the patient was diagnosed with multiple myeloma.

Vinayachandran, Divya; Sankarapandian, Sathasivasubramanian

2013-01-01

209

Multiple membrane cavity optomechanics  

NASA Astrophysics Data System (ADS)

We investigate theoretically the extension of cavity optomechanics to multiple membrane systems. We describe the simplest case of two membranes in a cavity, in terms of the coupling of the light fields to the breathing and center-of-mass modes of the membrane array. We show that these normal modes can be optically addressed individually and also be cooled, trapped, and characterized, e.g., via quantum nondemolition measurements. The extension to a larger number of membranes is briefly discussed.

Bhattacharya, M.; Meystre, P.

2008-10-01

210

Lipedema with multiple lipomas.  

PubMed

Lipedema is an underdiagnosed syndrome of unclear etiology, characterized by symmetric painful enlargement of the buttocks and lower extremities, which spares the feet. This enlargement is caused by the deposition of adipose tissue. It was first described by Allen and Hines in 1940, who observed that it had a female predilection; patients commonly had an associated family history. We describe a patient with classic lipedema and multiple lipomas of her arms and trunk. PMID:20875325

Pascucci, Anabella; Lynch, Peter J

2010-01-01

211

Universality of particle multiplicities  

SciTech Connect

We discuss the scaling properties and universality aspects of the rapidity and multiplicity distributions of particles produced in high energy hadronic and e{sup +}e{sup {minus}} interactions. This paper is based on material presented in three lectures on pomeron phenomenology, which included a review of traditional soft pomeron physics and selected topics on hard diffraction processes probing the structure function of the pomeron.

Goulianos, K. [Fermi National Accelerator Lab., Batavia, IL (United States)]|[Rockefeller Univ., New York, NY (United States)

1994-09-01

212

Multiple Primary Cancer Monograph  

Cancer.gov

To identify groups of cancer survivors that are at increased risk for multiple primary cancers, Radiation Epidemiology Branch (REB) investigators led a collaborative effort to provide the first comprehensive population-based analysis of the risk of subsequent cancer in the U.S. The 500-page monograph utilized data from nine cancer registries participating in the Surveillance, Epidemiology, and End Results (SEER) Program from 1973 to 2000.

213

On Multiple Moving Objects  

Microsoft Academic Search

This paper explores the motion-planning problem for multiple moving objects. The approach taken consists of assigning priorities\\u000a to the objects, then planning motions one object at a time. For each moving object, the planner constructs a configuration\\u000a space-time that represents the time-varying constraints imposed on the moving object by the other moving and stationary objects.\\u000a The planner represents this space-time

Michael Erdmann; Tomás Lozano-pérez

1987-01-01

214

Familial multiple lipomatosis.  

PubMed

A clinical study was made of 14 cases of multiple symmetrical lipomata in two families. There were 7 female and 7 male patients. In one family the members affected were observed in four generations. The disease set in during the third or fourth decade of life. The lipomata ranged in size from that of a pea to that of a hen's egg. They were limited to the forearms and trunk were asymptomatic. PMID:71835

Rabbiosi, G; Borroni, G; Scuderi, N

1977-01-01

215

Skylab Multiple Docking Adapter  

NASA Technical Reports Server (NTRS)

This December 1971 photograph shows the internal configuration of Skylab's Multiple Docking Adapter (MDA) as it appeared during the Crew Compartment and Function Review at the Martin-Marietta Corporation's Space Center facility in Denver, Colorado. At left is the control and display console for the Apollo Telescope Mount. Designed and manufactured by the Marshall Space Flight Center, the MDA housed a number of experiment control and stowage units and provided a docking port for the Apollo Command Module.

1971-01-01

216

Fulminant multiple sclerosis (MS).  

PubMed

Fulminant multiple sclerosis (MS) is the most malignant form of MS which usually leads to death in few weeks. Although it can be accompanied by optic neuritis (ON), but long interval between ON and the grave onset has not been reported. Fulminant MS usually occurs as the first onset and previous ON is not common. We report a rare case of 30-year-old woman with a history of ON 1 year ago. The rapid deterioration to vegetative state followed by a seizure and previous ON differentiated this case from previous reported cases. The differential diagnosis of a rapidly progressive leucoencephalopathy in this patient includes inflammatory, vascular, infectious and toxic disorders. Regarding the previous history of optic neuritis with positive brain MRI (multiple T2 hyperintense lesions in white matter) in our patient, multiple sclerosis is the most probable diagnosis. More effective treatments, such as plasmapheresis and cyclophosphamide, that influenced on the prognosis of some previous patients could be useful, but should be performed before progressive brain atrophy emerges. PMID:21863271

Rohani, Mohammad; Ghourchian, Shadi

2011-10-01

217

Multiple autoimmune syndrome  

PubMed Central

ABSTRACT The co-occurrence of autoimmune diseases has been epidemiologically studied and has aided in our understanding of autoimmunity. The combination of at least three autoimmune diseases in the same patient has defined as multiple autoimmune syndrome (MAS). About 25 percent of patients with autoimmune diseases have a tendency to develop additional autoimmune diseases. MAS is recognized with increasing frequency. Several associations have been proposed as a form of MAS. Multiple autoimmune syndrome can be classified into three groups according to the prevalence of their associations with one another: type 1, type 2 and type 3. Genetic, infectious, immunologic and psychological factors have all been implicated in the development of MAS. In MAS, patients often have at least one dermatological condition, usually vitiligo or alopecia areata. The pathogenesis of multiple autoimmune disorders is not known yet, perhaps environmental triggers and genetic susceptibility are involved. Abnormalities of both humoral and cell-mediated immunity have been described. However, as new perspectives develop on the pathogenesis and natural history of autoimmune diseases, a refinement in the methodology for the study of the co-occurrence of disease is warranted in order to maximize the information that one may realize from such studies. This paper presents some recent results of studies in light of current understanding of the natural history of autoimmune diseases.

COJOCARU, M; COJOCARU, Inimioara Mihaela; SILOSI, Isabela

2010-01-01

218

Multiple Coin Toss Model  

NSDL National Science Digital Library

The Ejs Multiple Coin Toss model displays the result of the flipping of N coins. The result of each set of coin flips is shown by the image of the pennies on the screen and the complete results of the tossing experiment is shown on a graph of the cumulative probability of heads. The number of coins flipped, N, and change the "fairness" of the coin by setting the probability of a "heads" result, p, can be set via text boxes. You can modify this simulation if you have Ejs installed by right-clicking within the plot and selecting âOpen Ejs Modelâ from the pop-up menu item. Ejs Multiple Coin Toss model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_MultipleCoinToss.jar file will run the program if Java is installed. Ejs is a part of the Open Source Physics Project and is designed to make it easier to access, modify, and generate computer models. Additional Ejs models for classical mechanics are available. They can be found by searching ComPADRE for Open Source Physics, OSP, or Ejs.

Christian, Wolfgang; Belloni, Mario

2008-11-15

219

Multiple Model Methods for Cost Function Based Multiple Hypothesis Trackers.  

National Technical Information Service (NTIS)

Multiple hypothesis trackers (MHTs) are widely accepted as the best means of tracking targets in clutter. This research seeks to incorporate multiple model Kalman filters into an Integral Square Error (ISE) cost-function- based MHT to increase the fidelit...

M. C. Kozak

2006-01-01

220

Twins, Triplets, and Other Multiples  

MedlinePLUS

... what? Pregnancy This information in Spanish ( en español ) Twins, triplets, and other multiples How twins are formed ... can increase the likelihood of multiple births. How twins are formed Twins form in one of two ...

221

The Functions of Multiple Representations.  

ERIC Educational Resources Information Center

Discusses multiple representations and multimedia learning environments; describes a functional taxonomy of MERs (multiple external representations); and considers how MERs are used to support cognitive processes in learning and problem solving with computers. (Contains 41 references.) (Author/LRW)

Ainsworth, Shaaron

1999-01-01

222

Multiple quantum well device  

NASA Astrophysics Data System (ADS)

A multiple quantum well device has a wide well and a plurality of narrower wells spaced from each other and sandwiched between a plurality of barriers and with quantum coupling existing between the wells. Semiconductor substrates and optimal well and barrier widths are selected to yield band gaps and charge localization within the wells such that the energy differences between the ground state of the wide well and the N excited states of a narrow wells correspond to the energy of a photon in the desired spectral range.

Schwartz, Carey

1991-07-01

223

Psychopathology in Multiple Sclerosis  

PubMed Central

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. Demyelinization of nerve fibres not only affects the motor and sensory systems functionally, but may also cause psychopathological signs and symptoms. In addition to the psychiatric manifestations of MS, many patients have reactive psychological problems that are often hard to distinguish from the ‘organic’ causation of psychopathology. In any event, psychiatric comorbidity in MS deserves greater clinical attention than has been previously paid, because the presence of psychopathology may have deleterious effects on the disease process and impair coping with disability.

Brune, Martin; Juckel, Georg

2009-01-01

224

Multiple endocrine adenopathy.  

PubMed

The syndromes of multiple endocrine adenopathy (MEA) have associated endocrine abnormalities that are similar to the clinical syndromes based in the same hyperfunctions of parathyroid, pancreatic islets, thyroid C-cell and chromaffin tissue seen in sporadic cases. The natural history, histopathology and management of these problems when they occur in the hereditary MEA syndromes differ in significant and instructive ways over the isolated disorders. These differences and similarities of MEA adenopathies were discussed at an international conference, with the suggestion that the MEA syndromes afford opportunity to investigate regulation and control of pathogenesis in surgical endocrinological syndromes. PMID:1357758

Geelhoed, G W; Van Heerden, J A; Hamberger, B; Johansson, H; Roher, H D; Indyk, J

1992-09-01

225

Multiplication Tables - Matching Cards  

NSDL National Science Digital Library

This interactive Flash version of the familiar Concentration game ("pelmanism" in the UK) helps a single user practice multiplication facts while developing memory and concentration skills. The player can choose an array of 16, 20, or 24 cards, which appear face down. The goal is to flip two cards at a time to match all the pairs of factors with their products as efficiently as possible. A scoring feature discourages random guessing. Users can choose to work with factors in three ranges: 2x-10x, 2x-21x, or 11x-21x. Printable versions of the game cards are available to download.

2001-03-01

226

Multiple fuel rod gripper  

SciTech Connect

The multiple fuel rod gripper comprises a plurality of split tube collets arranged to be inserted into corresponding tapered holes in a locking plate. When the gripper has been positioned to have a plurality of fuel rods disposed in the holes of locking plate, an actuating mechanism causes the collets to be inserted into the tapered holes thereby causing the fuel rods to be inserted in the collets. The taper of the holes forces the collets into locking engagement with the fuel rods so that the fuel rods may be extracted from the fuel assembly.

Shields, E. P.

1985-11-05

227

Matching among multiple random sequences  

Microsoft Academic Search

In searching for strong homologies between multiple nucleic acid or protein sequences, researchers commonly look at fixed-length\\u000a segments in common to the sequences. Such homologies form the foundation of segment-based algorithms for multiple alignment\\u000a of protein sequences. The researcher uses settings of “unusualness of multiple matches” to calibrate the algorithms. In applications\\u000a where a researcher has found a multiple matching

Joseph I. Naus; Ke-Ning Sheng

1997-01-01

228

Multiple myeloma with lung plasmacytoma  

PubMed Central

Malignant myeloma (MM) is a clonal proliferation of plasma cells with multiple osteolytic lesions. Extramedullary dissemination of multiple myeloma in lung is relatively uncommon. Hereby, we present a case of multiple myeloma with lung plasmacytoma of lung in a 45-years-old, non-smoker, female.

Prasad, Rajendra; Verma, Sanjay Kumar; Sodhi, Rakhi

2011-01-01

229

Multiple capillary biochemical analyzer  

DOEpatents

A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being analyzed, using a modified sheath flow cuvette. A linear or rectangular array of capillaries is introduced into a rectangular flow chamber. Sheath fluid draws individual sample streams through the cuvette. The capillaries are closely and evenly spaced and held by a transparent retainer in a fixed position in relation to an optical detection system. Collimated sample excitation radiation is applied simultaneously across the ends of the capillaries in the retainer. Light emitted from the excited sample is detected by the optical detection system. The retainer is provided by a transparent chamber having inward slanting end walls. The capillaries are wedged into the chamber. One sideways dimension of the chamber is equal to the diameter of the capillaries and one end to end dimension varies from, at the top of the chamber, slightly greater than the sum of the diameters of the capillaries to, at the bottom of the chamber, slightly smaller than the sum of the diameters of the capillaries. The optical system utilizes optic fibres to deliver light to individual photodetectors, one for each capillary tube. A filter or wavelength division demultiplexer may be used for isolating fluorescence at particular bands.

Dovichi, Norman J. (Edmonton, CA); Zhang, Jian Z. (Edmonton, CA)

1995-01-01

230

[Biomarkers in multiple sclerosis].  

PubMed

Multiple sclerosis is the most frequent disabling neurological disease in young adults. Its development includes independent processes of inflammation, demyelination, neurodegeneration, gliosis and repair, which are responsible for the heterogeneity and individual variability in the expression of the disease, its prognosis and response to treatment. As part of personalised medicine, the progress made in the search for new biomarkers has identified promising candidates that may be useful for the early diagnosis of the disease, for detecting prognostic and developmental profiles of the disease, and for monitoring the response to treatment. Unfortunately, few of them have been validated adequately, which prevents them from being applied in clinical practice. In view of the latest findings, the experts recommend orienting research in another direction, not so much towards the discovery of new molecules or imaging techniques, but instead towards a clinical validation of these markers, with the aim of fostering translational research. This review offers an update on the information about the biomarkers in multiple sclerosis that have currently been validated and are thus potential candidates, as well as looking at their value in the diagnosis, prognosis, evaluation of the development of the disability caused by the disease and the response to therapy. PMID:23520007

Fernández, Óscar; Arroyo-González, Rafael; Rodríguez-Antigüedad, Alfredo; García-Merino, Juan A; Comabella, Manuel; Villar, Luisa M; Izquierdo, Guillermo; Tintoré, Mar; Oreja-Guevara, Celia; Álvarez-Cermeño, José C; Meca-Lallana, José E; Prieto, José M; Ramió-Torrentà, Lluís; Martínez-Yélamos, Sergio; Montalban, Xavier

2013-04-01

231

Multiple capillary biochemical analyzer  

DOEpatents

A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being analyzed, using a modified sheath flow cuvette. A linear or rectangular array of capillaries is introduced into a rectangular flow chamber. Sheath fluid draws individual sample streams through the cuvette. The capillaries are closely and evenly spaced and held by a transparent retainer in a fixed position in relation to an optical detection system. Collimated sample excitation radiation is applied simultaneously across the ends of the capillaries in the retainer. Light emitted from the excited sample is detected by the optical detection system. The retainer is provided by a transparent chamber having inward slanting end walls. The capillaries are wedged into the chamber. One sideways dimension of the chamber is equal to the diameter of the capillaries and one end to end dimension varies from, at the top of the chamber, slightly greater than the sum of the diameters of the capillaries to, at the bottom of the chamber, slightly smaller than the sum of the diameters of the capillaries. The optical system utilizes optic fibers to deliver light to individual photodetectors, one for each capillary tube. A filter or wavelength division demultiplexer may be used for isolating fluorescence at particular bands. 21 figs.

Dovichi, N.J.; Zhang, J.Z.

1995-08-08

232

Phase-multiplication holography  

SciTech Connect

This disclosure relates generally to nondestructive testing for identifying structural characteristics of an object by scanned holographic techniques using a known source of radiation, such as electromagnetic or acoustical radiation. It is an object of this invention to provide an apparatus and method for synthetic aperture expansion in holographic imaging applications to construct fringe patterns capable of holographic reproduction where aperture restrictions in nondestructive testing applications would conventionally make such imaging techniques impossible. The apparatus and method result in the production of a sharply defined frontal image of structural characteristics which could not otherwise be imaged because they occur either near the surface of the object or are confined by geometry restricting aperture dimensions available for scanning purposes. The depth of the structural characteristic below the surface of the object can also be determined by the reconstruction parameters which produce the sharpest focus. Lateral resolution is established by simulated reduction in the radiation wavelength and may easily be an order of magnitude less than the electromagnetic wavelength in the material or 2 times the standard depth of penetration. Since the phase multiplication technique is performed on the detected data, the penetration depth available due to the longer wavelength signals applied to the test object remains unchanged. The phase multiplication technique can also be applied to low frequency acoustic holography, resulting in a test which combines excellent penetration of difficult materials with high resolution images.

Collins, H.D.; Prince, J.M.; Davis, T.J.

1982-01-25

233

[Simultaneous multiple hypertensive intracerebral hematoma].  

PubMed

Hypertensive intracerebral hemorrhage (HIH) occurring simultaneously in different locations is rare. We encountered 11 such cases between January 1990 and November 2002. The diagnosis of all 11 cases was established by computed tomography, and the location of the hematomas was: cerebellum and basal ganglia in 5 cases, pons and basal ganglia in 4, and subcortex and basal ganglia in 2. Our patients were analyzed with respect to clinical characteristics, pathogenesis of multiple hematomas, and indication of operation. These patients represented 1% of all 1,069 patients we encountered with HIH. As past history, there were no characteristic disorders except hypertension. There were no characteristic initial symptoms suggesting that hemorrhage had occurred simultaneously. Both supra- and infra-tentorial hematomas were observed in 80% of the patients, and the size of the multiple hematomas was proportional in principle. Cerebellar hematomas were often mild, and pontine hematomas were often severe. The outcome in those patients whose neurological grading was 1 to 3 was good with conservative therapy or surgical treatment. The severity, treatment methods, and outcomes in these patients were similar to those in patients with single HIH, which suggests only a slight influence of multiple lesions on outcome. As for the possible mechanism of simultaneous multiple hemorrhages, we speculated that bleeding occurred simultaneously in the different regions, or that the initial bleeding was followed after a short time by secondary bleeding due to high intracranial pressure and circulatory disturbance. In patients with cerebellar hematoma, initial symptoms suggested the development of secondary hemorrhage after primary hemorrhage. The surgical treatment for multiple hematomas should be determined by the location and maximum axis of the hematoma. We proposed that cerebellar hematomas should be removed if the supra-tentorial hematoma is small. PMID:15148798

Shiomi, Naoto; Miyagi, Tomoya; Koga, Satomi; Karukaya, Takashi; Tokutomi, Takashi; Shigemori, Minoru

2004-03-01

234

Does active gas seepage and dormant pockmarks indicate multiple episodes of focussed fluid escape along the SW Barents Sea?  

NASA Astrophysics Data System (ADS)

The SW Barents Sea is versatile in its evolution due to the effect of glaciations that have removed large thicknesses of sediments from the seabed. Unloading due to glacial erosion and deglaciation resulted in opening of pre-existing faults and creation of new ones facilitating fluid escape from the subsurface. The changes in ice load also altered the gas hydrate stability zone (GHSZ) thicknesses causing accumulation of gas as gas hydrates within the GHSZ and free gas below it. Expressions of fluid escape, pockmarks, are widely distributed in the Barents Sea. Several gas flares, some of them 200 metre high, occur along a segment of the Ringvassøy Loppa Fault Complex (RLFC), indicating open fractures and still highly active fluid flow. Observation of gas flares along regional fault complexes outside the pockmark region indicate that the present gas escape activity occurs along these faults mainly. The relatively small thickness of sediments infilling the pockmarks and their penetration of the marine-glaciomarine sediment boundary indicate that they formed after deposition of glaciomarine sediments and were active in the Holocene and possibly some of them to the recent past. Methane hydrate stability zone (MHSZ) modelling shows that by the deglaciation after the Last Glacial Maximum (LGM) ca. 20 000 14C years ago, the MHSZ had thinned from 600 meters to zero in most parts of the SW Barents Sea. The fluid expulsion probably happened after the retreat of the grounded marine ice sheet causing the release of methane from melting methane hydrates through slow fluid escape process which lasted until recent creating pockmarks. Fluids are also leaking from deeper source rocks through formation pathways focussed by stratigraphic boundaries and open faults.

Chand, S.; Thorsnes, T.; Rise, L.; Brunstad, H.; Stoddart, D.; Bøe, R.; Lågstad, P.; Svolsbru, T.

2012-12-01

235

Multiple jet study  

NASA Technical Reports Server (NTRS)

Test data is presented which allows determination of jet penetration and mixing of multiple cold air jets into a ducted subsonic heated mainstream flow. Jet-to-mainstream momentum flux ratios ranged from 6 to 60. Temperature profile data is presented at various duct locations up to 24 orifice diameters downstream of the plane of jet injection. Except for two configurations, all geometries investigated had a single row of constant diameter orifices located transverse to the main flow direction. Orifice size and spacing between orifices were varied. Both of these were found to have a significant effect on jet penetration and mixing. The best mixing of the hot and cold streams was achieved with duct height.

Walker, R. E.; Kors, D. L.

1973-01-01

236

The Multiple Telescope Telescope  

NASA Astrophysics Data System (ADS)

Designed and constructed by the Georgia State University Department of Physics and Astronomy, the Multiple Telescope Telescope (MTT) is an efficient, inexpensive 1 meter instrument dedicated to spectroscopic observations. The MTT is composed of nine mirrors, each focused on a separate fiber bundle which is fed directly into a Newtonian-Ebert spectrograph designed for medium to high resolution spectroscopy. The light weight of the optics and small size of the telescope allow for an inexpensive design that any university could conceivably construct. The MTT has been used primarily for observation and reconstruction of separated binary spectra, though work with giant stars, stellar oscillations, and Comet Hale-Bopp are among the other projects that have utilized the MTT.

Riddle, R. L.; Bagnuolo, W. G.; Barry, D. J.

1999-12-01

237

Multiple layer insulation cover  

DOEpatents

A multiple layer insulation cover for preventing heat loss in, for example, a greenhouse, is disclosed. The cover is comprised of spaced layers of thin foil covered fabric separated from each other by air spaces. The spacing is accomplished by the inflation of spaced air bladders which are integrally formed in the cover and to which the layers of the cover are secured. The bladders are inflated after the cover has been deployed in its intended use to separate the layers of the foil material. The sizes of the material layers are selected to compensate for sagging across the width of the cover so that the desired spacing is uniformly maintained when the cover has been deployed. The bladders are deflated as the cover is stored thereby expediting the storage process and reducing the amount of storage space required.

Farrell, James J. (Livingston Manor, NY); Donohoe, Anthony J. (Ovid, NY)

1981-11-03

238

Headache in Multiple Sclerosis  

PubMed Central

The aim of this study was to investigate the variables affecting headache occurrence in patients with multiple sclerosis (MS). Seventy-two MS patients with comorbid headaches completed a 28-item questionnaire. This evaluation assessed each patient's demographics, headache description and modifying factors, social history, and impact on quality of life. Our patients reported a wide spectrum of headache presentations, characteristics, and resulting disability. We discuss the patterns in our data in the context of current hypotheses regarding headache and MS causality. In our patients, migraines with aura strongly correlated with MS exacerbations, suggesting that they might be useful as a marker for flare-up onset. Patients' pain descriptions varied based on their headache frequency, history, and relationship to MS progression. Due to the severity of headache in MS patients and resulting impact on their activities of daily living, a thorough analysis of headache presentation is warranted in such patients.

Majeed, Muhammad Hassan; Youngman, Branden; Wilcox, Jessica

2013-01-01

239

Multiple retroperitoneal paragangliomas.  

PubMed

Paragangliomas are rare with multicentricity being more common in patients with familial history. Early recognition of the characteristic symptoms of headache, palpitations, and diaphoresis in a patient with hypertension and prompt appropriate intervention can minimize the morbidity associated with such tumors and prevent a potentially fatal outcome. Paragangliomas represent neoplasms of neural crest origin that arise from paraganglia. Paragangliomas are tumours arising in extra-adrenal paraganglia either in the paravertebral space. We report a rare case of two discrete paragangliomas in the retroperitoneum of a young girl presenting with throbbing headache. Contrast Enhanced CT Abdomen showed the lesions as a large irregular heterogeneous and intensely enhancing mass lesions. Elevated levels of vanillylmandelic acid were found in the Urine. The lesions were removed by surgery and the histopathologic findings of both the lesions confirmed the diagnosis of multiple paragangliomas. Early identification and early surgery will minimize the potential risks and complications in this condition. PMID:24426538

Rai, Santosh; Subas, K; Kini, J; Bhat, N; Rao, S

2013-06-01

240

Swamp Works- Multiple Projects  

NASA Technical Reports Server (NTRS)

My Surface Systems internship over the summer 2013 session covered a broad range of projects that utilized multiple fields of engineering and technology. This internship included a project to create a command center for a 120 ton regolith bin, for the design and assembly of a blast shield to add further protection for the Surface Systems engineers, for the design and assembly of a portable four monitor hyper wall strip that could extend as large as needed, research and programming a nano drill that could be utilized on a next generation robot or rover, and social media tasks including the making of videos, posting to social networking websites and creation of a new outreach program to help spread the word about the Swamp Works laboratory.

Carelli, Jonathan M.; Schuler, Jason M.; Chandler, Meredith L.

2013-01-01

241

Mixed Mode Matrix Multiplication  

SciTech Connect

In modern clustering environments where the memory hierarchy has many layers (distributed memory, shared memory layer, cache,...), an important question is how to fully utilize all available resources and identify the most dominant layer in certain computations. When combining algorithms on all layers together, what would be the best method to get the best performance out of all the resources we have? Mixed mode programming model that uses thread programming on the shared memory layer and message passing programming on the distributed memory layer is a method that many researchers are using to utilize the memory resources. In this paper, they take an algorithmic approach that uses matrix multiplication as a tool to show how cache algorithms affect the performance of both shared memory and distributed memory algorithms. They show that with good underlying cache algorithm, overall performance is stable. When underlying cache algorithm is bad, superlinear speedup may occur, and an increasing number of threads may also improve performance.

Meng-Shiou Wu; Srinivas Aluru; Ricky A. Kendall

2004-09-30

242

Tremor in multiple sclerosis  

PubMed Central

Tremor is estimated to occur in about 25 to 60 percent of patients with multiple sclerosis (MS). This symptom, which can be severely disabling and embarrassing for patients, is difficult to manage. Isoniazid in high doses, carbamazepine, propranolol and gluthetimide have been reported to provide some relief, but published evidence of effectiveness is very limited. Most trials were of small size and of short duration. Cannabinoids appear ineffective. Tremor reduction can be obtained with stereotactic thalamotomy or thalamic stimulation. However, the studies were small and information on long-term functional outcome is scarce. Physiotherapy, tremor reducing orthoses, and limb cooling can achieve some functional improvement. Tremor in MS remains a significant challenge and unmet need, requiring further basic and clinical research.

Mostert, Jop; Heersema, Dorothea; De Keyser, Jacques

2007-01-01

243

Nutrition in multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is a chronic idiopathic inflammatory demyelinating disease that causes neurological disability in young adults. Etiology of the disease is still unknown, but it has an immune-mediated basis and occurs in genetically susceptible individuals. Nutritional status and dietary habits in MS patients have not been extensively studied or reported, however individual findings suggest that many patients suffer from various forms of malnutrition. In patients with MS, malnutrition has been associated with impairment of the immune system; it affects mental function, respiratory muscle strength and increases a risk of specific nutrient deficiencies. These findings emphasize the need for nutritional support in MS patients. On the other hand, several nutritional compounds have been investigated as a possible treatment in MS, mostly polyunsaturated fatty acids and vitamin D, however their role in the treatment is yet to be confirmed. The aim of this review is to present data on the role of nutritional assessment and treatment in patients with MS. PMID:20444538

Habek, Mario; Hojsak, Iva; Brinar, Vesna V

2010-09-01

244

Phylogeographical Analysis of mtDNA Data Indicates Postglacial Expansion from Multiple Glacial Refugia in Woodland Caribou (Rangifer tarandus caribou)  

PubMed Central

Glacial refugia considerably shaped the phylogeographical structure of species and may influence intra-specific morphological, genetic, and adaptive differentiation. However, the impact of the Quaternary ice ages on the phylogeographical structure of North American temperate mammalian species is not well-studied. Here, we surveyed ?1600 individuals of the widely distributed woodland caribou (Rangifer tarandus caribou) using mtDNA control region sequences to investigate if glacial refugia contributed to the phylogeographical structure in this subspecies. Phylogenetic tree reconstruction, a median-joining network, and mismatch distributions supported postglacial expansions of woodland caribou from three glacial refugia dating back to 13544–22005 years. These three lineages consisted almost exclusively of woodland caribou mtDNA haplotypes, indicating that phylogeographical structure was mainly shaped by postglacial expansions. The putative centres of these lineages are geographically separated; indicating disconnected glacial refugia in the Rocky Mountains, east of the Mississippi, and the Appalachian Mountains. This is in congruence with the fossil record that caribou were distributed in these areas during the Pleistocene. Our results suggest that the last glacial maximum substantially shaped the phylogeographical structure of this large mammalian North American species that will be affected by climatic change. Therefore, the presented results will be essential for future conservation planning in woodland caribou.

Klutsch, Cornelya F. C.; Manseau, Micheline; Wilson, Paul J.

2012-01-01

245

Individual classification of children with epilepsy using support vector machine with multiple indices of diffusion tensor imaging  

PubMed Central

Introduction Support vector machines (SVM) have recently been demonstrated to be useful for voxel-based MR image classification. In the present study we sought to evaluate whether this method is feasible in the classification of childhood epilepsy intractability based on diffusion tensor imaging (DTI), with adequate accuracy. We applied SVM in conjunction DTI indices of fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). DTI studies have reported white matter abnormalities in childhood-onset epilepsy, but the mechanisms underlying these abnormalities are not well understood. The aim of this study was to examine the relationship between epileptic seizures and cerebral white matter abnormalities identified by DTI in children with active compared to remitted epilepsy utilizing an automated and unsupervised classification method. Methods The DTI data were tensor-derived indices including FA, MD, AD and RD in 49 participants including 20 children with epilepsy 5–6 years after seizure onset as compared to healthy controls. To determine whether there was normalization of white matter diffusion behavior following cessation of seizures and treatment, the epilepsy subjects were grouped into those with active versus remitted epilepsy. Group comparisons were previously made examining FA, MD and RD via whole-brain tract-based spatial statistics (TBSS). The SVM analysis was undertaken with the WEKA software package with 10-fold cross validation. Weighted sensitivity, specificity and accuracy were measured for all the DTI indices for two classifications: (1) controls vs. all children with epilepsy and (2) controls vs. children with remitted epilepsy vs. children with active epilepsy. Results Using TBSS, significant differences were identified between controls and all children with epilepsy, between controls and children with active epilepsy, and also between the active and remitted epilepsy groups. There were no significant differences between the remitted epilepsy and controls on any DTI measure. In the SVM analysis, the best predictor between controls and all children with epilepsy was MD, with a sensitivity of 90–100% and a specificity between 96.6 and 100%. For the three-way classification, the best results were for FA with 100% sensitivity and specificity. Conclusion DTI-based SVM classification appears promising for distinguishing children with active epilepsy from either those with remitted epilepsy or controls, and the question that arises is whether it will prove useful as a prognostic index of seizure remission. While SVM can correctly identify children with active epilepsy from other groups' diagnosis, further research is needed to determine the efficacy of SVM as a prognostic tool in longitudinal clinical studies.

Amarreh, Ishmael; Meyerand, Mary E.; Stafstrom, Carl; Hermann, Bruce P.; Birn, Rasmus M.

2014-01-01

246

Using a summary measure for multiple quality indicators in primary care: the Summary QUality InDex (SQUID)  

PubMed Central

Background Assessing the quality of primary care is becoming a priority in national healthcare agendas. Audit and feedback on healthcare quality performance indicators can help improve the quality of care provided. In some instances, fewer numbers of more comprehensive indicators may be preferable. This paper describes the use of the Summary Quality Index (SQUID) in tracking quality of care among patients and primary care practices that use an electronic medical record (EMR). All practices are part of the Practice Partner Research Network, representing over 100 ambulatory care practices throughout the United States. Methods The SQUID is comprised of 36 process and outcome measures, all of which are obtained from the EMR. This paper describes algorithms for the SQUID calculations, various statistical properties, and use of the SQUID within the context of a multi-practice quality improvement (QI) project. Results At any given time point, the patient-level SQUID reflects the proportion of recommended care received, while the practice-level SQUID reflects the average proportion of recommended care received by that practice's patients. Using quarterly reports, practice- and patient-level SQUIDs are provided routinely to practices within the network. The SQUID is responsive, exhibiting highly significant (p < 0.0001) increases during a major QI initiative, and its internal consistency is excellent (Cronbach's alpha = 0.93). Feedback from physicians has been extremely positive, providing a high degree of face validity. Conclusion The SQUID algorithm is feasible and straightforward, and provides a useful QI tool. Its statistical properties and clear interpretation make it appealing to providers, health plans, and researchers.

Nietert, Paul J; Wessell, Andrea M; Jenkins, Ruth G; Feifer, Chris; Nemeth, Lynne S; Ornstein, Steven M

2007-01-01

247

What Happens After Treatment for Multiple Myeloma?  

MedlinePLUS

... Topic Lifestyle changes after having multiple myeloma What happens after treatment for multiple myeloma? For most people, multiple myeloma never goes away completely. These people may get regular ...

248

Current progress in using multiple electromagnetic indicators to determine location, time, and magnitude of earthquakes in California and Peru (Invited)  

NASA Astrophysics Data System (ADS)

Since ultra-low frequency (ULF) magnetic anomalies were discovered prior to the 1989 Loma Prieta, Ca. M7.0 earthquake, QuakeFinder, a small R&D group based in Palo Alto California has systematically monitored ULF magnetic signals with a network of 3-axis induction magnetometers since 2000 in California. This raw magnetometer data was collected at 20-50 samples per sec., with no preprocessing, in an attempt to collect an accurate time history of electromagnetic waveforms prior to, during, and after large earthquakes within 30 km. of these sensors. Finally in October 2007, the QuakeFinder team observed a series of strange magnetic pulsations at the Alum Rock, California site, 14 days prior to M5.4 earthquake. These magnetic signals observed were relatively short, random pulsations, not continuous waveform signals like Pc1 or Pc3 micropulsations. The magnetic pulses have a characteristic uni-polar shapes and 0.5 sec. to 30 sec. durations, much longer than lightning signals. In May of 2010, very similar pulses were observed at Tacna, Peru, 13 days prior to a M6.2 earthquake, using a QuakeFinder station jointly operated under collaboration with the Catholic University in Lima Peru (PUCP). More examples of these pulsations were sought, and a historical review of older California magnetic data discovered fewer but similar pulsations occurred at the Hollister, Ca. site operated by UC Berkeley (e.g. San Juan Bautista M5.1 earthquake on August 12, 1998). Further analysis of the direction of arrival of the magnetic pulses showed an interesting “azimuth clustering” observed in both Alum Rock, Ca. and Tacna, Peru data. The complete time series of the Alum Rock data allowed the team to analyze subsequent changes observed in magnetometer “filter banks” (0.001 Hz to 10 Hz filter bands, similar to those used by Fraser-Smith in 1989), but this time using time-adjusted limits based on time of day, time of year, Kp, and site background noise. These site-customized limits showed similar increases in 30 minute averaged energy excursions, but the 30 minute averages had a disadvantage in that they reduced the signal to noise ratio over the individual pulse counting method. In other electromagnetic monitoring methods, air conductivity instrumentation showed major changes in positive air-borne ions observed near the Alum Rock and Tacna sites, peaking during the 24 hours prior to the earthquake. The use of GOES (geosynchronous) satellite infra red (IR) data showed that an unusual apparent “night time heating” occurred in an extended area within 40+ km. of the Alum Rock site, and this IR signature peaked around the time of the magnetic pulse count peak. The combination of these 3 indicators (magnetic pulse counts, air conductivity, and IR night time heating) may be the start in determining the time (within 1-2 weeks), location (within 20-40km) and magnitude (within +/- 1 increment of Richter magnitude) of earthquake greater than M5.4

Bleier, T. E.; Dunson, C.; Roth, S.; Heraud, J.; Freund, F. T.; Dahlgren, R.; Bryant, N.; Bambery, R.; Lira, A.

2010-12-01

249

Multiple tree-ring isotopes as environmental indicators of diffuse atmospheric pollution in a peri-urban area  

NASA Astrophysics Data System (ADS)

The combined analyses of tree-ring ?13C, ?18O, ?15N, 206Pb/207Pb, 206Pb/204Pb and 206Pb/208Pb isotope ratios of three red spruce specimens from the Tantaré ecological reserve located 40 km northwest of Québec City (Canada) were studied with the aim of reconstructing environmental conditions and unravel past air-quality changes of the 1880-2007 period. To separate the tree-ring ?18O and ?13C patterns induced by natural conditions from those generated by anthropogenic perturbations, a linear regression was applied between the most explicative meteorological parameters and the isotopic series for the period of low pollution (1880 to 1909). The model equations were then applied to the most recent part of the series (1910-2007) to verify if climatic conditions have remained the main driver of the tree-ring isotopic variations. The good fit between the modeled and measured ?18O series for the entire studied period suggests that the assimilation of oxygen by red spruce trees is not significantly affected by pollution stress near Québec City. However, the deviation between the measured and modeled ?13C values for the 1944-2007 period indicates that diffuse pollution affected carbon assimilation by the investigated trees. To independently validate if atmospheric pollution could have generated the deviation between the measured and the estimated ?13C values, a linear regression was applied between the portion of the residual ?13C values and atmospheric pollution (Canadian fossil fuel proxy from 1958 to 2000). The nice fit between the modeled ?13C values from the combination of the two regression analyses based on climate and emission proxy strongly supports the hypothesis that there is a natural and an anthropogenic portion in the ?13C variations of the studied specimens. The short-term variations of the red spruce ?15N series are correlated with the instrumentally measured amounts of provincial N emissions for the 1990 to 2006 period (longest measurements available). Additionally, the long-term decrease of the ?15N series after 1956 is linked to the low isotopic values of NOx emitted by car exhausts, as expressed by the provincial number of cars which reflect the amount of transport-related N deposition at the provincial scale. The 208Pb/206Pb and 204Pb/206Pb ratios as a function of 206Pb/207Pb of the 1880-1919 period reflect a mixture of natural lead from the mineral soil horizon and mainly anthropogenic lead from north-eastern American coal combustion. The lower Pb ratios of the 1920-1989 period correlate well with the introduction of leaded additives to gasoline characterized by lower ratios relative to coal combustion. Inferring the lead sources of the 1990-2008 period is not as straightforward because lead can potentially derive from three main sources: coal combustion, burnt recycled material and natural lead present in soils. Our results show the great potential of tree-ring stable isotopes to record pollution events in the context of peri-urban diffuse pollution, and to prolong the pollution history in regions where direct measurements of pollutants only covers a relatively short period.

Doucet, A.; Savard, M. M.; Bégin, C.; Ouarda, T. B.; Marion, J.

2010-12-01

250

Improved Repeated Measures Stepwise Multiple Comparison Procedures.  

ERIC Educational Resources Information Center

Results of a study of repeated measures stepwise multiple comparison procedures indicate that multiple range procedures modified according to Duncan's (1975) method and employing nonpooled omnibus or pairwise stepwise procedures are robust to violations of the multisample sphericity assumption and are typically more powerful than the usual range…

Keselman, H. J.; Lix, Lisa M.

1995-01-01

251

The Distributive Property: The Core of Multiplication  

ERIC Educational Resources Information Center

This article presents a sequence of learning activities that lead to using the area model of multiplication to understand the distributive property (DP). The connection between area and multiplication is an important one, both for algebraic thinking and for geometry, as indicated in two of the critical areas for the third grade in the Common Core…

Kinzer, Cathy J.; Stanford, Ted

2013-01-01

252

Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method.  

PubMed Central

Hepatic elimination of epidermal growth factor (EGF) via receptor-mediated endocytosis was studied by a multiple-indicator dilution method in the isolated perfused rat liver, in which cell polarity and spatial organization are maintained. In this method EGF was given with inulin, an extracellular reference, as a bolus into the portal vein, and dilution curves of both compounds in the hepatic vein effluent were analyzed. Analysis of the dilution curve for EGF, compared with that for somatostatin, which showed no specific binding to isolated liver plasma membranes, resulted as follows: (i) both extraction ratio and distribution volume of 125I-labeled EGF decreased as the injected amount of unlabeled EGF increased; (ii) the ratio plot [ln (inulin/EGF) versus time] of the dilution curve for EGF exhibited an upward straight line initially for a short period of time (approximately equal to 10 sec), whereas the ratio plot [ln (inulin/somatostatin) versus time] of somatostatin gradually decreased. The multiple-indicator dilution method was used for other peptides also. Insulin and glucagon, known to have hepatocyte receptors, behaved similarly to EGF in shape of their ratio plots. Thus, analysis of dilution curves can reveal whether or not the cell surface has receptors for certain peptides. In addition, the dilution curves for EGF at various doses (tracer approximately equal to 30 micrograms) were analyzed simultaneously based on a kinetic model incorporating the perfusion rate, the association rate constant of EGF to surface receptors (kappa on), the dissociation rate constant of EGF from the EGF-receptor complex (kappa off), and the sequestration rate constant of the complex. The kinetic parameters [the dissociation constant (Kd = kappa off/kappa on) and the number of surface receptors] calculated by this analysis were comparable with reported values obtained by in vitro direct binding measurements at equilibrium using liver homogenates. We conclude that the multiple-indicator dilution method is a good tool for analyzing the dynamics of peptide hormones--cell-surface receptor interaction under a condition in which spatial architecture of the liver is maintained.

Sato, H; Sugiyama, Y; Sawada, Y; Iga, T; Sakamoto, S; Fuwa, T; Hanano, M

1988-01-01

253

Multiple sclerosis and glutamate excitotoxicity.  

PubMed

The previous understanding of multiple sclerosis was solely related to neuroinflammation and its harmful effects; however, countless data indicate the importance of some inflammation-independent, neurodegenerative mechanisms associated with mitochondria malfunction, iron deposition and oxidative stress. Recently, it has been postulated that glutamate excitotoxicity, a phenomenon that takes place when an excessive amount of glutamate overactivates its cellular receptors and induces cell death, could be a missing link between inflammatory and neurodegenerative processes evident in multiple sclerosis. Glutamate is the major excitatory neurotransmitter of the central nervous system, which has been proven to have a central role in a complex communication network established between all residential brain cells, including neurons, astrocytes, oligodendrocytes and microglia. Thus, the disturbance of glutamate homeostasis could affect practically all physiological functions and interactions of brain cells, leading to heterogeneity of pathological events. The understanding of glutamate excitotoxicity as a valid mechanism of central nervous system damage in multiple sclerosis, requires the revision of the current knowledge about a source of elevated extracellular glutamate, glutamate receptor alterations, alterations of glutamate transporters and metabolizing enzymes, as well as molecular mechanism of excitotoxic damage. PMID:23152401

Kostic, Milos; Zivkovic, Nikola; Stojanovic, Ivana

2013-01-01

254

Trapezium-type multiple systems  

NASA Astrophysics Data System (ADS)

Trapezium-type multiple systems are one of the youngest systems in the galaxy. Ambartsumian (1954) regards many of the Trapezium-type multiple systems as having positive total energy. The examination of a table, compiled from the Abastumani Catalogue of Trapezia (Salukvadze, 1978; Poveda et al., 1977) and the Index Catalogue of Visual Binary Stars, shows that real trapezia are met among multiple stars with their primaries of O and B spectral types.

Salukvadze, G. N.

1986-01-01

255

Thermoregulation in multiple sclerosis  

PubMed Central

Multiple sclerosis (MS) is a progressive neurological disorder that disrupts axonal myelin in the central nervous system. Demyelination produces alterations in saltatory conduction, slowed conduction velocity, and a predisposition to conduction block. An estimated 60–80% of MS patients experience temporary worsening of clinical signs and neurological symptoms with heat exposure. Additionally, MS may produce impaired neural control of autonomic and endocrine functions. This review focuses on five main themes regarding the current understanding of thermoregulatory dysfunction in MS: 1) heat sensitivity; 2) central regulation of body temperature; 3) thermoregulatory effector responses; 4) heat-induced fatigue; and 5) countermeasures to improve or maintain function during thermal stress. Heat sensitivity in MS is related to the detrimental effects of increased temperature on action potential propagation in demyelinated axons, resulting in conduction slowing and/or block, which can be quantitatively characterized using precise measurements of ocular movements. MS lesions can also occur in areas of the brain responsible for the control and regulation of body temperature and thermoregulatory effector responses, resulting in impaired neural control of sudomotor pathways or neural-induced changes in eccrine sweat glands, as evidenced by observations of reduced sweating responses in MS patients. Fatigue during thermal stress is common in MS and results in decreased motor function and increased symptomatology likely due to impairments in central conduction. Although not comprehensive, some evidence exists concerning treatments (cooling, precooling, and pharmacological) for the MS patient to preserve function and decrease symptom worsening during heat stress.

Wilson, Thad E.; White, Andrea T.; Frohman, Elliot M.

2010-01-01

256

Multiple Myeloma: An Update  

PubMed Central

Multiple myeloma is a rare, largely incurable malignant disease of plasma cells. Patients usually present with hypercalcemia, renal insufficiency, anemia and/or lytic bony lesions along with a monoclonal protein in the serum and/or urine in addition to an increase in the number of clonal plasma cells in the bone marrow. Patients with myeloma live on an average for five to seven years, with their survival dependent on the presence or absence of different prognostic markers. Treatment of younger fit patients is with induction therapy consisting of steroids with one or more novel anti-myeloma agents followed by high dose melphalan and autologous stem cell transplantation, while older and less fit patients are treated with melphalan-based combination chemotherapy. Supportive care is of paramount importance and includes the use of bisphosphonates, prophylactic antibiotics, thrombosis prophylaxis and the use of hematopoietic growth factors along with the treatment of complications of disease and its therapy. As more progress is being made and deeper responses are being attained, the disease might turn into a potentially curable one in the near future.

Al-Farsi, Khalil

2013-01-01

257

[Congenital multiple arthrogryposis].  

PubMed

From 1975 to 2004 a total of 38 children handicapped by congenital multiple arthrogryposis were cared for. The congenital joint contractures demand a major effort in terms of surgical reconstruction. In the case of distal arthrogryposis the chances that patients will be able to walk without help are good, while those with amyoplasia are likely to be dependent on mobility aids throughout their lives. The ultimate goal of treatment for patients is to develop into self-confident adults who can cope with life despite their handicaps. The hip in arthrogryposis shows variable forms of pathology, ranging from the almost normal hip to hip contractures with dislocation. Its treatment has some limited advantages, but hardly improves mobility. The knee contractures are actively treated to allow patients to sit, stand and walk better. The club foot and the rocker-bottom foot need sophisticated conservative and operative treatments. If conservative manipulation of bilateral extension contractures of the elbow fails operative treatment is carried out on the dominant side. For shoulder, hand and finger contractures conservative manipulation brings about little improvement, and surgical approaches help hardly at all. PMID:17323063

Parsch, Klaus; Pietrzak, Szymon

2007-03-01

258

Multiple sensor geocoded data  

NASA Astrophysics Data System (ADS)

The problem of integrating remotely sensed images acquired from different sensor systems is primarily associated with their registration into a common reference projection. This registration problem has to be considered not only between the image data themselves but also with other data already existing in various geographical data bases. The advent of the second generation of earth observation satellites is emphasizing this situation by providing imagery in different geometric configurations. Images will be acquired from many sensors at different spatial resolutions (LANDSAT MSS and TM, SPOT HRV MLA and PLA) on different dates and modes (panchromatic, multispectral, nadir and off-nadir). In order to provide image data in a geometric format compatible with the Canadian National Topographic System, Canada is developing a Multi-Observational Satellite Image Correction System (MOSAICS) that will provide geocoded data resampled into a common reference projection. This paper presents the characteristics of the geocoded products with examples from multiple sensors and different dates, and addresses the processing requirements of the satellite ground station. It also illustrates the use of digital processing techniques to derive digital elevation information from geocoded stereo imagery.

Guertin, F. E.; Friedmann, D.; Simard, R.; Brown, R. J.; Teillet, P. M.

259

Multiple stage railgun  

DOEpatents

A multiple stage magnetic railgun accelerator (10) for accelerating a projectile (15) by movement of a plasma arc (13) along the rails (11,12). The railgun (10) is divided into a plurality of successive rail stages (10a-n) which are sequentially energized by separate energy sources (14a-n) as the projectile (15) moves through the bore (17) of the railgun (10). Propagation of energy from an energized rail stage back towards the breech end (29) of the railgun (10) can be prevented by connection of the energy sources (14a-n) to the rails (11,12) through isolation diodes (34a-n). Propagation of energy from an energized rail stage back towards the breech end of the railgun can also be prevented by dividing the rails (11,12) into electrically isolated rail sections (11a-n, 12a-n). In such case means (55a-n) are used to extinguish the arc at the end of each energized stage and a fuse (31) or laser device (61) is used to initiate a new plasma arc in the next energized rail stage.

Hawke, Ronald S. (Livermore, CA); Scudder, Jonathan K. (Pleasanton, CA); Aaland, Kristian (Livermore, CA)

1982-01-01

260

Multiple myeloma and diagnostic imaging.  

PubMed

Multiple myeloma is the most common primary bone cancer among U.S. adults aged 70 years and older, and the incidence of the disease is increasing. Despite significant advances in treatment since the 1960s, multiple myeloma remains a challenging disease to diagnose and treat. Several medical diagnostic imaging examinations play important roles. This article reviews the biological basis of multiple myeloma, clinical features and diagnosis of the disease, and imaging and treatment protocols. The article also discusses unusual presentations of multiple myeloma. PMID:24614435

Reisenbuckler, Carol

2014-01-01

261

Fast Parallel Realization of Matrix Multiplication.  

National Technical Information Service (NTIS)

Fast parallel matrix multiplication algorithms in SIMD (Single-Instruction-Multiple-Data) and MIMD (MUltiple-Instruction-Multiple-data) modes are described for implementation in a parallel-binary matrix processing system with facilities for bit-wise paral...

E. V. Krishnamurthy R. Klette

1979-01-01

262

Multiple Imputation Strategies for Multiple Group Structural Equation Models  

Microsoft Academic Search

Although structural equation modeling software packages use maximum likelihood estimation by default, there are situations where one might prefer to use multiple imputation to handle missing data rather than maximum likelihood estimation (e.g., when incorporating auxiliary variables). The selection of variables is one of the nuances associated with implementing multiple imputation, because the imputer must take special care to preserve

Craig K. Enders; Amanda C. Gottschall

2011-01-01

263

Time Reversal in Multiple-Input Multiple-Output Radar  

Microsoft Academic Search

Time reversal explores the rich scattering in a multipath environment to achieve high target detectability. Multiple-input multiple-output (MIMO) radar is an emerging active sensing technology that uses diverse waveforms transmitted from widely spaced antennas to achieve increased target sensitivity when compared to standard phased arrays. In this paper, we combine MIMO radar with time reversal to automatically match waveforms to

Yuanwei Jin; JosÉ M. F. Moura; Nicholas O'Donoughue

2010-01-01

264

A multiple objective evolutionary algorithm for multiple sequence alignment  

Microsoft Academic Search

The problem of multiple sequence alignment is important for bioinformatics. This problem is widely studied and a popular tool to solve this problem is Clustal X. This work introduces a multiple objective evolutionary algorithm to improve solutions obtained from Clustal X. The proposed method is tested with the dataset from BAliBASE database.

Pasut Seeluangsawat; Prabhas Chongstitvatana

2005-01-01

265

Control of Multiple Service, Multiple Resource Communication Networks  

Microsoft Academic Search

The authors focus upon communication networks that integrate multiple services using multiple resources. In particular, the authors address the decision of whether to accept or deny service requests in such a system. A conjecture for the optimal policy for a related system introduced by G.J. Foschini and B. Gopinath (1983) is proved, and the optimal coordinate convex policy for a

Scott Jordan; Pravin Varaiya

1991-01-01

266

Swamp Works- Multiple Projects  

NASA Technical Reports Server (NTRS)

My Surface Systems internship over the summer 2013 session covered a broad range of projects that ranged multiple aspects and fields of engineering and technology. This internship included a project to create a command center for a 120 ton regolith bin, a design and build for a blast shield to add further protection for the Surface Systems engineers, a design for a portable four monitor hyper wall that can extend as large as needed, research and programming a nano drill for a next generation robot, and social media tasks including the making of videos, posting to social networking websites and implementation of a new weekly outreach program to help spread the word about the Swamp Works laboratory. The objectives for the command center were to create a central computer controlled area for the still in production lunar regolith bin. It needed to be easy to use and the operating systems had to be Linux. The objectives for the hyper wall were to build a mobile transport of monitors that could potentially attach to one another. It needed to be light but sturdy, and have the ability to last. The objectives for the blast shield included a robust design that could withstand a small equipment malfunction, while also being convenient for use. The objectives for the nano-drill included the research and implementation of programming for vertical and horizontal movement. The hyper wall and blasts shield project were designed by me in the Pro/Engineer/Creo2 software. Each project required a meeting with the Swamp Works engineers and was declared successful.

Carelli, Jonathan M.

2013-01-01

267

The influence of multiple indices of socioeconomic disadvantage across the adult life course on the metabolic syndrome: the Vietnam Experience Study.  

PubMed

Few studies have explored the relationship between individual and combined multiple indicators of socioeconomic status across the life course and the metabolic syndrome, or attempted to understand the mechanisms underlying any associations. The present study examined the associations between 4 indicators of socioeconomic status, individually and in combination, and metabolic syndrome risk in a study of male US veterans and examined the influence of health behaviors, intelligence, and psychologic distress on these associations. Participants (N = 4253) were drawn from the Vietnam Experience Study. From military service files, telephone interviews, and a medical examination, occupational, sociodemographic, health behavior, intelligence, psychologic, and health data were collected. The 4 indices of socioeconomic status were as follows: education achieved, early adulthood income, household income in midlife, and occupational prestige in midlife. Metabolic syndrome was diagnosed from the following: body mass index, fasting blood glucose or a diagnosis of diabetes, blood pressure-a diagnosis of hypertension or taking antihypertensives, high-density lipoprotein cholesterol, and triglyceride levels. In models that adjusted for age, men in the lower 2 groups on the combined measure of socioeconomic status experienced a higher risk of metabolic syndrome. This association was accounted for mainly by education achieved, household income in midlife, and occupational prestige in midlife. Intelligence appeared to explain much of this association. Combined socioeconomic status measures across the life course were related to metabolic syndrome but in a threshold rather than dose-response manner. Intelligence appeared to mediate this relationship. PMID:20045139

Phillips, Anna C; Carroll, Douglas; Thomas, G Neil; Gale, Catharine R; Deary, Ian; Batty, G David

2010-08-01

268

Multiple Surveys of Students and Survey Fatigue  

ERIC Educational Resources Information Center

This chapter reviews the literature on survey fatigue and summarizes a research project that indicates that administering multiple surveys in one academic year can significantly suppress response rates in later surveys. (Contains 4 tables.)

Porter, Stephen R.; Whitcomb, Michael E.; Weitzer, William H.

2004-01-01

269

Multiple phases of protien gels  

Microsoft Academic Search

A multiple phase transition was observed in gels made by covalently cross-linking proteins in either native or denatured state. The enzymatic activity of the gels prepared from native alpha-chymotrypsin was determined for each of the multiple phases. The reversibility of the swelling degrees and the enzymatic reaction rates upon phase transition suggests that the protein is at a free energy

Masahiko Annaka; Toyoichi Tanaka

1994-01-01

270

Multiple Intelligences and Lab Groups  

ERIC Educational Resources Information Center

Science teachers who are committed to excellence in the classroom continually seek ways to improve teaching and learning, and the concept of multiple intelligences holds promise as a method for accomplishing this. The essence of the theory of multiple intelligences is to understand the many differences among students, the variations in the ways…

Colannino, Noreen M.; Hoyt, William L.; Murray, Ann

2004-01-01

271

Multiplicity distributions in nuclear collisions  

SciTech Connect

Multiplicity distributions in nuclear collisions are calculated in the framework of the dual parton model. A comparison with experimental data is performed. The multiplicity distributions for /sup 16/O-/sup 207/Pb collisions at 200 Gev/c per nucleon is predicted. The fluctuations of the energy density in the central rapidity region for such collisions are estimated.

Capella, A.; Casado, J.A.; Pajares, C.; Ramallo, A.V.; Tran Tranh Van, J.

1987-05-01

272

Outflows from Newborn Multiple Stars  

Microsoft Academic Search

Analysis of a sample of giant Herbig-Haro flow sources shows that 79% - 86% are binaries or higher order multiples. This represents the youngest sample of stars studied so far for binarity. A stellar dynamics jet hypothesis is proposed in which the dynamical decay of triple or multiple systems leads to giant outflow activity. Close triple approaches will cause serious

Bo Reipurth

2001-01-01

273

Multiple sequence alignments in linguistics  

Microsoft Academic Search

In this study we apply and evaluate an iterative pairwise alignment program for producing multiple sequence alignments, ALPHAMALIG (Alonso et al., 2004), us- ing as material the phonetic transcriptions of words used in Bulgarian dialectological research. To evaluate the quality of the multiple alignment, we propose two new methods based on comparing each column in the obtained alignments with the

Martijn Wieling; John Nerbonne

274

Multiple sclerosis associated with trismus.  

PubMed Central

This report describes the case history of a middle-aged lady who presented with symptoms and signs over one year leading to a diagnosis of multiple sclerosis. During one of her relapses, she developed trismus--an association that has not been described before in multiple sclerosis.

D'Costa, D. F.; Vania, A. K.; Millac, P. A.

1990-01-01

275

The problem with multiple robots  

NASA Technical Reports Server (NTRS)

The issues that can arise in research associated with multiple, robotic agents are discussed. Two particular multi-robot projects are presented as examples. This paper was written in the hope that it might ease the transition from single to multiple robot research.

Huber, Marcus J.; Kenny, Patrick G.

1994-01-01

276

Multiple Intelligences Centers and Projects.  

ERIC Educational Resources Information Center

Based upon Gardner's theory of multiple intelligences, this book guides elementary school teachers through the process of using classroom learning centers and projects by providing choices for students. The guide is divided into two sections, providing the theoretical background and information on how to develop multiple intelligences learning…

Chapman, Carolyn; Freeman, Lynn

277

Bent Bonds and Multiple Bonds.  

ERIC Educational Resources Information Center

Considers carbon-carbon multiple bonds in terms of Pauling's bent bond model, which allows direct calculation of double and triple bonds from the length of a CC single bond. Lengths of these multiple bonds are estimated from direct measurements on "bent-bond" models constructed of plastic tubing and standard kits. (CS)

Robinson, Edward A.; Gillespie, Ronald J.

1980-01-01

278

Teaching for Mastery of Multiplication  

ERIC Educational Resources Information Center

The strategies for learning multiplication concepts are discussed. The strategies involve introduction of the multiplication concepts through problem solutions with linkage between new concepts and prior knowledge, provision of concrete experiences and semi-concrete representations prior to purely symbolic notations, explicit teaching of the rules…

Wallace, Ann H.; Gurganus, Susan P.

2005-01-01

279

Multiple Hypothesis Testing with Groups  

Microsoft Academic Search

In the context of large-scale multiple hypothesis testing, the hypotheses often possess certain group structures based on additional information such as Gene On- tology in gene expression data and phenotypes in genome-wide association studies. It is hence desirable to incorporate such information when dealing with multiplicity problems to increase statistical power. In this article, we demonstrate the benet of considering

James X. Hu; Hongyu Zhao; Harrison H. Zhou

280

Multiplication Fact Fluency Using Doubles  

ERIC Educational Resources Information Center

Not knowing multiplication facts creates a gap in a student's mathematics development and undermines confidence and disposition toward further mathematical learning. Learning multiplication facts is a first step in proportional reasoning, "the capstone of elementary arithmetic and the gateway to higher mathematics" (NRC 2001, p. 242). Proportional…

Flowers, Judith M.; Rubenstein, Rheta N.

2010-01-01

281

Multiple-Valued Quantum Logic  

Microsoft Academic Search

This paper introduces the concept of multiple- valued quantum logic, where more than two quantum basis states are introduced, for instance { 0 , 1 , 2 } for ternary quantum logic. Since the binary 2-qubit Einstein-Podolsky-Rosen (EPR) basis states play an important role in quantum logic circuits and superdense coding, their generalization to multiple-valued N-qubit EPR basis states is

Anas Al-Rabadi; Lee Casperson; Marek Perkowski; Xiaoyu Song

2002-01-01

282

Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells.  

PubMed

Translocations in myeloma are thought to occur solely in mature B cells in the germinal center through class switch recombination (CSR). We used a targeted captured technique followed by massively parallel sequencing to determine the exact breakpoints in both the immunoglobulin heavy chain (IGH) locus and the partner chromosome in 61 presentation multiple myeloma samples. The majority of samples (62%) have a breakpoint within the switch regions upstream of the IGH constant genes and are generated through CSR in a mature B cell. However, the proportion of CSR translocations is not consistent between cytogenetic subgroups. We find that 100% of t(4;14) are CSR-mediated; however, 21% of t(11;14) and 25% of t(14;20) are generated through DH-JH recombination activation gene-mediated mechanisms, indicating they occur earlier in B-cell development at the pro-B-cell stage in the bone marrow. These 2 groups also generate translocations through receptor revision, as determined by the breakpoints and mutation status of the segments used in 10% and 50% of t(11;14) and t(14;20) samples, respectively. The study indicates that in a significant number of cases the translocation-based etiological events underlying myeloma may arise at the pro-B-cell hematological progenitor cell level, much earlier in B-cell development than was previously thought. PMID:23435460

Walker, Brian A; Wardell, Christopher P; Johnson, David C; Kaiser, Martin F; Begum, Dil B; Dahir, Nasrin B; Ross, Fiona M; Davies, Faith E; Gonzalez, David; Morgan, Gareth J

2013-04-25

283

Using multiple chemical indicators to characterize and determine the age of groundwater from selected vents of the silver springs group, Central Florida, USA  

USGS Publications Warehouse

The Silver Springs Group, Florida (USA), forms the headwaters of the Silver River and supports a diverse ecosystem. The 30 headwater springs divide into five subgroups based on chemistry. Five selected spring vents were sampled in 2007 to better understand the contaminant sources and groundwater flow system. Elevated nitrate-N concentrations (>0.8mg/L) in the five spring vents likely originate from inorganic (fertilizers) and organic sources, based on nitrogen and oxygen isotope ratios of nitrate. Evidence for denitrification in the Lost River Boil spring includes enriched ??15N and ??18O, excess N2 gas, and low dissolved O2 concentrations (<0.5mg/L). Multiple age-tracer data (SF6, 3H, tritiogenic 3He) for the two uppermost springs (Mammoth East and Mammoth West) indicate a binary mixture dominated by recent recharge water (mean age 6-7 years, and 87-97% young water). Tracer data for the three downstream spring vents (Lost River Boil, Catfish Hotel-1, and Catfish Conventional Hall-1) indicate exponential mixtures with mean ages of 26-35 years. Contamination from non-atmospheric sources of CFCs and SF5CF3 precluded their use as age tracers here. Variations in chemistry were consistent with mean groundwater age, as nitrate-N and dissolved O2 concentrations were higher in younger waters, and the Ca/Mg ratio decreased with increasing mean age. ?? 2010 Springer-Verlag (outside the USA).

Knowles, Jr. , L.; Katz, B. G.; Toth, D. J.

2010-01-01

284

Using multiple chemical indicators to characterize and determine the age of groundwater from selected vents of the Silver Springs Group, central Florida, USA  

NASA Astrophysics Data System (ADS)

The Silver Springs Group, Florida (USA), forms the headwaters of the Silver River and supports a diverse ecosystem. The 30 headwater springs divide into five subgroups based on chemistry. Five selected spring vents were sampled in 2007 to better understand the contaminant sources and groundwater flow system. Elevated nitrate-N concentrations (>0.8 mg/L) in the five spring vents likely originate from inorganic (fertilizers) and organic sources, based on nitrogen and oxygen isotope ratios of nitrate. Evidence for denitrification in the Lost River Boil spring includes enriched ?15N and ?18O, excess N2 gas, and low dissolved O2 concentrations (<0.5 mg/L). Multiple age-tracer data (SF6, 3H, tritiogenic 3He) for the two uppermost springs (Mammoth East and Mammoth West) indicate a binary mixture dominated by recent recharge water (mean age 6-7 years, and 87-97% young water). Tracer data for the three downstream spring vents (Lost River Boil, Catfish Hotel-1, and Catfish Conventional Hall-1) indicate exponential mixtures with mean ages of 26-35 years. Contamination from non-atmospheric sources of CFCs and SF5CF3 precluded their use as age tracers here. Variations in chemistry were consistent with mean groundwater age, as nitrate-N and dissolved O2 concentrations were higher in younger waters, and the Ca/Mg ratio decreased with increasing mean age.

Knowles, Leel; Katz, Brian G.; Toth, David J.

2010-12-01

285

Multiple Participants, Multiple Locations, Multiple Time Zones and Multitasking in the Synchronous Cyber Classroom  

Microsoft Academic Search

This paper describes the use of the synchronous cyber classroom with multiple participants from multiple locations and time-zones in socially networked learning communities around the world. It reports enhanced cognitive function, higher participation and lower attrition rates, and collaborative teaching and learning during facilitated synchronous sessions. Data was drawn from a seven year trial of synchronous teaching and learning with

Megan Hastie; Nian-shing Chen; Ross J. Todd

2008-01-01

286

Multiple sclerosis and multiple sclerosis-associated retrovirus in Sardinia  

Microsoft Academic Search

.   The island of Sardinia has a high and increasing incidence of multiple sclerosis (MS). In a search for environmental factors\\u000a that may account for this anomalously high incidence, we looked for evidence of multiple sclerosis-associated retrovirus (MSRV)\\u000a that has previously been found in the plasma and cerebrospinal fluid of MS patients. We studied 25 MS patients and 25 matched

C. Serra; S. Sotgiu; G. Mameli; M. Pugliatti; G. Rosati; A. Dolei

2001-01-01

287

Sequential versus parallel architecture for Multiple sensors Multiple target tracking  

Microsoft Academic Search

In this paper, we propose to compare Parallel and sequential architectures for Multi-sensor Multi-target tracking. This contribution aims to contribute in solving the problem of model-based body motion estimation by using data coming from multiple visual sensors. To ensure accurate track we use the interacting multiple model (IMM) associated with the unscented Kalman filter (IMM-UKF). To resolve the problem of

Wissem Saidani; Yacine Morsly; Mohand Djouadi

2008-01-01

288

All About Multiplication: Modeling Multiplication with Rows and Columns  

NSDL National Science Digital Library

"This lesson encourages students to explore the array model of multiplication. The lesson focuses on the factors 4 and 6. Students will also explore products with 0 or 1 as a factors. First students make arrays with counters, and then they create a second concrete example of the array model using toothpicks. They also write problems which involve multiplication." (from NCTM's Illuminations) This is lesson 3 in a 4-lesson unit.

Math, Illuminations N.

2009-03-16

289

Proton interactions with high multiplicity  

SciTech Connect

Project Thermalization is aimed to study the proton-proton interaction with high multiplicity of secondary particles. The region of high multiplicity is especially actual at present. We expect the manifestation of the secondary particle collective behavior at this region. The experimentally measured topological cross section was corrected for apparatus acceptance and detection efficiency. These data are in good agreement with gluon dominance model. The comparison with other models is also done and shows no essential deviations. There is evidence that Bose-Einstein condensation can formed at high total multiplicity region.

Kokoulina, E. S., E-mail: kokoulin@sunse.jinr.ru; Nikitin, V. A.; Petukhov, Y. P. [LHEP, JINR (Russian Federation); Kutov, A. Ya. [Department of Mathematics Komi SC UrD RAS (Russian Federation)

2012-06-15

290

Spearfishing Regulation Benefits Artisanal Fisheries: The ReGS Indicator and Its Application to a Multiple-Use Mediterranean Marine Protected Area  

PubMed Central

The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a marine protected area (MPA) and the benefit it provides for the local artisanal fishery through the use of a novel indicator. We analysed trends in the fish assemblage composition using artisanal fisheries data collected in the Bonifacio Strait Natural Reserve (BSNR), a Mediterranean MPA where the spearfishing activity has been forbidden over 15% of its area. Fish species were pooled into three response groups according to their target level by spearfishing. We developed the new flexible ReGS indicator reflecting shifts in species assemblages according to the relative abundance of each response group facing external pressure. The catch per unit effort (CPUE) increased by ca. 60% in the BSNR between 2000 and 2007, while the MPA was established in 1999. The gain of CPUE strongly depended on the considered response group: for the highly targeted group, the CPUE doubled while the CPUE of the untargeted group increased by only 15.5%. The ReGS value significantly increased from 0.31 to 0.45 (on a scale between 0 and 1) in the general perimeter of this MPA while it has reached a threshold of 0.43, considered as a reference point, in the area protected from spearfishing since 1982. Our results demonstrated that limiting recreational fishing by appropriate zoning in multiple-use MPAs represents a real benefit for artisanal fisheries. More generally we showed how our new indicator may reveal a wide range of impacts on coastal ecosystems such as global change or habitat degradation.

Rocklin, Delphine; Tomasini, Jean-Antoine; Culioli, Jean-Michel; Pelletier, Dominique; Mouillot, David

2011-01-01

291

Multiple Indicator Cluster Survey 2003 in Afghanistan: Outdated Sampling Frame and the Effect of Sampling Weights on Estimates of Maternal and Child Health Coverage  

PubMed Central

Due to an urgent need for information on the coverage of health service for women and children after the fall of Taliban regime in Afghanistan, a multiple indicator cluster survey (MICS) was conducted in 2003 using the outdated 1979 census as the sampling frame. When 2004 pre-census data became available, population-sampling weights were generated based on the survey-sampling scheme. Using these weights, the population estimates for seven maternal and child healthcare-coverage indicators were generated and compared with the unweighted MICS 2003 estimates. The use of sample weights provided unbiased estimates of population parameters. Results of the comparison of weighted and unweighted estimates showed some wide differences for individual provincial estimates and confidence intervals. However, the mean, median and absolute mean of the differences between weighted and unweighted estimates and their confidence intervals were close to zero for all indicators at the national level. Ranking of the five highest and the five lowest provinces on weighted and unweighted estimates also yielded similar results. The general consistency of results suggests that outdated sampling frames can be appropriate for use in similar situations to obtain initial estimates from household surveys to guide policy and programming directions. However, the power to detect change from these estimates is lower than originally planned, requiring a greater tolerance for error when the data are used as a baseline for evaluation. The generalizability of using outdated sampling frames in similar settings is qualified by the specific characteristics of the MICS 2003—low replacement rate of clusters and zero probability of inclusion of clusters created after the 1979 census.

Shuaib, Muhammad; Becker, Stan; Rahman, Md. Mokhlesur; Peters, David H.

2011-01-01

292

Multiplicative processes in visual cognition  

NASA Astrophysics Data System (ADS)

The Central Limit Theorem (CLT) is certainly one of the most important results in the field of statistics. The simple fact that the addition of many random variables can generate the same probability curve, elucidated the underlying process for a broad spectrum of natural systems, ranging from the statistical distribution of human heights to the distribution of measurement errors, to mention a few. An extension of the CLT can be applied to multiplicative processes, where a given measure is the result of the product of many random variables. The statistical signature of these processes is rather ubiquitous, appearing in a diverse range of natural phenomena, including the distributions of incomes, body weights, rainfall, and fragment sizes in a rock crushing process. Here we corroborate results from previous studies which indicate the presence of multiplicative processes in a particular type of visual cognition task, namely, the visual search for hidden objects. Precisely, our results from eye-tracking experiments show that the distribution of fixation times during visual search obeys a log-normal pattern, while the fixational radii of gyration follow a power-law behavior.

Credidio, H. F.; Teixeira, E. N.; Reis, S. D. S.; Moreira, A. A.; Andrade, J. S.

2014-03-01

293

Neurophysiological investigations in multiple sclerosis.  

PubMed

The advent of magnetic resonance imaging techniques has greatly reduced the diagnostic value of neurophysiological tests, particularly evoked potentials, in multiple sclerosis patients, because of the higher sensitivity in revealing subclinical involvement of the central nervous system. Technical progress and new methods of investigating afferent and efferent nervous pathways would seem to increase the sensitivity in detecting neural dysfunction, but the 'clinical gain' is modest at best. More promising is the utilization of neurophysiological tests to quantify the severity of white matter involvement. Transversal and longitudinal studies have demonstrated good correlations between neurophysiological parameters and disability measures, indicating that a battery of neurophysiological tests could be useful in monitoring the disease evolution in single patients and as surrogate endpoints in clinical trials. Further studies are needed for a better definition of the applications of evoked potentials and other neurophysiological techniques. Finally, event-related potentials and advanced electroencephalogram techniques, such as coherence analysis, could provide useful information on the pathophysiology of cognitive dysfunction, so common in multiple sclerosis patients, and with a strong impact on the quality of life. PMID:10871248

Leocani, L; Comi, G

2000-06-01

294

Repeated multiple maternities in triplet families.  

PubMed

In earlier studies, scientists have attempted to identify genetic and environmental factors affecting the rate of multiple maternities among humans. We contribute to these studies by analysing the frequencies of multiple maternities in sibships containing triplets. Use of the Hellin transformation is included in evaluation of the triplet rate. Our results indicate greater frequencies of repeated multiple maternities in the sibships than expected, based on population frequencies. The excesses obtained are more marked in triplet maternities than in twin maternities. The transformed triplet rate shows results similar to the twinning rate. The findings also indicate that in families, the influence of maternal factors on the frequencies of multiple maternities is stronger than the influence of paternal factors. PMID:24717303

Fellman, Johan; Eriksson, Aldur W

2014-06-01

295

[Ocular motor disorders in multiple sclerosis].  

PubMed

Multiple sclerosis is the most common disabling neurological disease in young people. Many neuro-ophthalmological manifestations can occur during the course of the illness, and optic neuritis is both the most frequent and the best known. However, some ocular motility disorders can also occur, but since there may be no symptoms, they often remain underdiagnosed. These eye movement disorders are mostly related to brain-stem and cerebellum lesions. They can be acute, indicating a spatial dissemination of the demyelinating disease, and consequently may indicate the need for systemic treatment of multiple sclerosis. More often, they evolve slowly, progressing with the multiple sclerosis. In this case, they could provide a clue to the prognosis of the disease. In this survey, we discuss the two major symptoms of ocular motor disorders likely to occur during multiple sclerosis: oscillopsia and diplopia. PMID:18971858

Rougier, M-B; Tilikete, C

2008-09-01

296

Multiple Regression and Its Discontents  

ERIC Educational Resources Information Center

Multiple regression is part of a larger statistical strategy originated by Gauss. The authors raise questions about the theory and suggest some changes that would make room for Mandelbrot and Serendipity.

Snell, Joel C.; Marsh, Mitchell

2012-01-01

297

Multiple Antibiotic Resistance Operon Assays.  

National Technical Information Service (NTIS)

An isolated and cloned region of a bacterial chromosome containing a multiple antibiotic resistance operon is disclosed. A description of the structure and function of the operon is provided as are assorted recombinant DNA constructs involving the operon ...

S. B. Levy

2004-01-01

298

Multiplicities in high energy interactions  

SciTech Connect

This paper reviews the data on multiplicities in high energy interactions. Results from e/sup +/e/sup -/ annihilation, from neutrino interactions, and from hadronic collisions, both diffractive and nondiffractive, are compared and contrasted. The energy dependence of the mean charged multiplicity, , as well as the rapidity density at Y = 0 are presented. For hadronic collisions, the data on neutral pion production shows a strong correlation with . The heavy particle fractions increase with ..sqrt..s up to the highest energies. The charged particle multiplicity distributions for each type of reaction show a scaling behavior when expressed in terms of the mean. Attempts to understand this behavior, which was first predicted by Koba, Nielsen, and Olesen, are discussed. The multiplicity correlations and the energy variation of the shape of the KNO scaling distribution provide important constraints on models. Some extrapolations to the energies of the Superconducting Super Collider are made. 51 refs., 27 figs.

Derrick, M.

1985-05-13

299

Multiple myeloma. Houses and spouses  

SciTech Connect

Two families in which successive spouses who lived in the same house developed multiple myeloma are reported. In the first instance, a man whose first wife died of multiple myeloma remarried, and his second wife also developed myeloma. In the second family, a woman's first husband died of multiple myeloma and her second husband did too. Radiation studies of the houses and yards showed no increased radioactivity. No evidence was found for excessive exposure to chemicals or other environmental agents, for contact with other patients having similar malignancies, or for exposure to viruses or other transmissible factors. The significance of the occurrence of multiple myeloma in subsequent spouses is unknown. It is hoped that this report will stimulate research for other instances and lead to careful epidemiologic, radiologic, and virologic studies.

Kyle, R.A.; Greipp, P.R.

1983-02-15

300

MULTIPLE SCALES FOR SUSTAINABLE RESULTS  

EPA Science Inventory

This session will highlight recent research that incorporates the use of multiple scales and innovative environmental accounting to better inform decisions that affect sustainability, resilience, and vulnerability at all scales. Effective decision-making involves assessment at mu...

301

Lung Multiple Primary Rules Matrix  

Cancer.gov

Lung Multiple Primary Rules – Matrix C340-C349 (Excludes lymphoma and leukemia M9590 – 9989 and Kaposi sarcoma M9140) * Prepare one abstract. Use the histology coding rules to assign the appropriate histology code. ** Prepare two or more abstracts.

302

Multiple Threat Generator (MTG-100).  

National Technical Information Service (NTIS)

This technical report describes the Multiple Threat Generator (MTG-100) designed, developed, fabricated, installed and tested at Rome Air Development Center, by Republic Electronic Industries Corp. The report describes the purpose of the equipment, gives ...

J. Michaels

1980-01-01

303

The Importance of Multiple Choice.  

National Technical Information Service (NTIS)

A level of organization of inferences in which competing plausible alternatives can be compared, and all but one actively rejected, is a very important aspect of any comprehension model. Multiple choice inference structures help the model stay tuned to th...

C. Rieger

1978-01-01

304

The genetics of multiple sclerosis.  

PubMed

Epidemiological studies implicate an interplay between genetic and environmental factors in the aetiology of multiple sclerosis. The classical genetic observations suggest that multiple sclerosis is a complex trait in which susceptibility is determined by several genes acting independently or epistatically. The main dividend from understanding the genetic basis of susceptibility in multiple sclerosis will be an improved understanding of the pathogenesis. To date, candidate gene approaches have proved relatively unrewarding other than in establishing the association with alleles of the major histocompatibility complex (MHC). In common with most other complex traits, no major susceptibility gene has been identified through full genome screens but regions of interest have provisionally been identified. An important part of future studies in the genetics of multiple sclerosis will be to resolve the question of disease heterogeneity. PMID:10871776

Compston, A

2000-05-01

305

If I Had - Multiple Sclerosis  

MedlinePLUS Videos and Cool Tools

... In Depth In the Spotlight If I Had... Universities and Hospitals By Disease or Symptom View QuickTime ... John (Jock) Murray, MD, FRCP(C), OC, Dalhousie University Back to Home Page If I Had - Multiple ...

306

Multiple, Parallel, Spatial Phase Measurement.  

National Technical Information Service (NTIS)

A signal processing apparatus for providing accurate electrical phase difference measurement of multiple concurrent signal inputs is disclosed. Phase measurement of an individual signal input is accompished utilizing an efficient spatial sampling scheme. ...

H. L. Levitt A. Y. Tsee

1995-01-01

307

Paroxysmal symptoms in multiple sclerosis.  

PubMed Central

The clinical features of paroxysmal symptoms occurring in 26 patients with multiple sclerosis are reviewed. The findings are considered to provide further support for the concept of lateral spread of axonal excitation within demyelinated plaques. Images

Matthews, W B

1975-01-01

308

Multiple phases of protien gels  

NASA Astrophysics Data System (ADS)

A multiple phase transition was observed in gels made by covalently cross-linking proteins in either native or denatured state. The enzymatic activity of the gels prepared from native ?-chymotrypsin was determined for each of the multiple phases. The reversibility of the swelling degrees and the enzymatic reaction rates upon phase transition suggests that the protein is at a free energy minimum and thus in a phase.

Annaka, Masahiko; Tanaka, Toyoichi

1994-03-01

309

The INEL beryllium multiplication experiment  

SciTech Connect

The experiment to measure the multiplication of 14-MeV neutrons in bulk beryllium has been completed. The experiment consists of determining the ratio of {sup 56}Mn activities induced in a large manganese bath by a central 14-MeV neutron source, with and without a beryllium sample surrounding the source. In the manganese bath method a neutron source is placed at the center of a totally-absorbing aqueous solution of MnSo{sub 4}. The capture of neutrons by Mn produces a {sup 56}Mn activity proportional to the emission rate of the source. As applied to the measurement of the multiplication of 14- MeV neutrons in bulk beryllium, the neutron source is a tritium target placed at the end of the drift tube of a small deuteron accelerator. Surrounding the source is a sample chamber. When the sample chamber is empty, the neutrons go directly to the surrounding MnSO{sub 4} solution, and produce a {sup 56}Mn activity proportional to the neutron emission rate. When the chamber contains a beryllium sample, the neutrons first enter the beryllium and multiply through the (n,2n) process. Neutrons escaping from the beryllium enter the bath and produce a {sup 56}Mn activity proportional to the neutron emission rate multiplied by the effective value of the multiplication in bulk beryllium. The ratio of the activities with and without the sample present is proportional to the multiplication value. Detailed calculations of the multiplication and all the systematic effects were made with the Monte Carlo program MCNP, utilizing both the Young and Stewart and the ENDF/B-VI evaluations for beryllium. Both data sets produce multiplication values that are in excellent agreement with the measurements for both raw and corrected values of the multiplication. We conclude that there is not real discrepancy between experimental and calculated values for the multiplication of neutrons in bulk beryllium. 12 figs., 11 tabs., 18 refs.

Smith, J.R.; King, J.J.

1991-03-01

310

Coloring Multiples in Pascal's Triangle  

NSDL National Science Digital Library

This Java applet activity allows the learner to visually identify number patterns in Pascal's triangle as they color multiples of a given number. The user can also click on an auto-color button that will automatically color the multiples of the given number. The number of rows of Pascal's triangle can be increased or decreased. There are separate tabs to access information for the learner, the instructor and to seek help.

2004-01-01

311

Studies of porcine circovirus type 2, porcine boca-like virus and torque teno virus indicate the presence of multiple viral infections in postweaning multisystemic wasting syndrome pigs.  

PubMed

In a previous study, using random amplification and large-scale sequencing technology, we identified a novel porcine parvovirus belonging to the genus Bocavirus in the background of porcine circovirus type 2 (PCV-2) in Swedish pigs with postweaning multisystemic wasting syndrome (PMWS). In addition to bocavirus we demonstrated the presence of torque teno virus (TTV) genogroups 1 and 2 in these cases of PMWS, indicating the simultaneous presence of several viruses in this disease complex. In the present study, 34 PMWS-affected animals and 24 pigs without PMWS were screened by PCR for the presence of PCV-2, TTV-1, TTV-2 and porcine boca-like virus (Pbo-likeV). The studies revealed the following infection rates in the PMWS-affected pigs: PCV-2 100%, TTV-1 77%, TTV-2 94% and Pbo-likeV 88%. In comparison, the pigs without PMWS had the following rates: PCV-2 80%, TTV-1 79%, TTV-2 83% and Pbo-likeV 46%. The sequence identity between the different Swedish Pbo-likeV sequences ranged between 98% and 100%. By checking co-infection, it was found that 71% of the PMWS-affected pigs harbor simultaneously all these viruses. As a contrast, in the group without PMWS only 33% of the animals were positive simultaneously for these viruses. These observations indicate a multiple viral infection in PMWS-affected pigs. It has to be studied further if the clinical manifestation of PMWS might be due to synergistic effects of different viruses acting together. PMID:20542066

Blomström, Anne-Lie; Belák, Sándor; Fossum, Caroline; Fuxler, Lisbeth; Wallgren, Per; Berg, Mikael

2010-09-01

312

Representation of Multiplication Facts-Evidence for partial verbal coding  

PubMed Central

Background The current view in numerical cognition research is that multiplication facts are stored and retrieved in a phonological code. Consistent with this view, it was found that multiplication could be impaired by a phonological but not by a visuo-spatial loading task. However, because the authors used an active production task, it remained unclear whether concurrent articulation impaired either access to multiplication facts or their retrieval. Methods In the current study, we investigated the influence of concurrent articulation on multiplication fact knowledge without active production of multiplication results. Results In a number bisection task, number triplets, which are part of a multiplication table, were classified faster as being correctly bisected than other triplets. Interestingly, concurrent articulation led to a relative slowing of the multiplicative triplets which reduced the multiplicativity effect. Conclusions This result indicates that concurrent articulation modulates access to phonologically stored multiplication facts and corroborates the notion of multiplication facts being represented in an at least partially verbal code.

2011-01-01

313

Cognitive Dysfunction in Multiple Sclerosis  

PubMed Central

In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes particularly important. In this review the authors address: the cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing, and visual–spatial abilities); the pathophysiological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance; the most used tests and batteries for neuropsychological assessment; therapeutic strategies to improve cognitive abilities.

Guimaraes, Joana; Sa, Maria Jose

2012-01-01

314

Multiple Myeloma: Treatment Options by Stage  

MedlinePLUS

... information for multiple myeloma Treatment options for multiple myeloma by stage Solitary plasmacytomas These are often treated ... is only used if multiple myeloma develops. Early myeloma Early myeloma includes smoldering myeloma and stage I ...

315

Multiple pigmented follicular cysts: a subtype of multiple pilosebaceous cysts.  

PubMed

Pigmented follicular cyst is a rare disorder which typically presents as a pigmented papule on the head or neck and which, histologically, exhibits terminally differentiated, pigmented hair shafts in an epidermoid cyst. We report a 22-year-old man with the multiple variant of this disorder. Clinically he had numerous brown-blue to flesh-coloured, domed-shaped papules, on the anterior chest and abdomen, of 10 years duration. Histologically, hybrid cysts exhibiting trichilemmal and epidermoid keratinization were seen. The cysts contained numerous pigmented, terminally differentiated hair shafts and, embedded in the wall of one cyst, was a sebaceous gland. The condition of multiple pigmented follicular cysts, is thought to represent a distinct subtype within the spectrum of multiple pilosebaceous cystic disorders. PMID:8733387

Salopek, T G; Lee, S K; Jimbow, K

1996-04-01

316

The MARVEL assembly for neutron multiplication.  

PubMed

A new multiplying test assembly is under development at Idaho National Laboratory to support research, validation, evaluation, and learning. The item is comprised of three stacked, highly-enriched uranium (HEU) cylinders, each 11.4 cm in diameter and having a combined height of up to 11.7 cm. The combined mass of all three cylinders is 20.3 kg of HEU. Calculations for the bare configuration of the assembly indicate a multiplication level of >3.5 (k(eff)=0.72). Reflected configurations of the assembly, using either polyethylene or tungsten, are possible and have the capability of raising the assembly's multiplication level to greater than 10. This paper describes simulations performed to assess the assembly's multiplication level under different conditions and describes the resources available at INL to support the use of these materials. We also describe some preliminary calculations and test activities using the assembly to study neutron multiplication. PMID:23827507

Chichester, David L; Kinlaw, Mathew T

2013-10-01

317

Interger multiplication with overflow detection or saturation  

SciTech Connect

High-speed multiplication is frequently used in general-purpose and application-specific computer systems. These systems often support integer multiplication, where two n-bit integers are multiplied to produce a 2n-bit product. To prevent growth in word length, processors typically return the n least significant bits of the product and a flag that indicates whether or not overflow has occurred. Alternatively, some processors saturate results that overflow to the most positive or most negative representable number. This paper presents efficient methods for performing unsigned or two's complement integer multiplication with overflow detection or saturation. These methods have significantly less area and delay than conventional methods for integer multiplication with overflow detection and saturation.

Schulte, M.J.; Balzola, P.I.; Akkas, A.; Brocato, R.W.

2000-01-11

318

Active search for multiple targets is inefficient.  

PubMed

This study examines saccade strategy in a novel task where observers actively search a display to find multiple targets in a limited time. Theory predicts that the relative merit of different saccade strategies depends on the prior probability of the target at a location: when the target prior is low and multiple-target trials are rare, making a saccade to the most likely target location is close to the optimal strategy, but when the target prior is high and multiple-target trials are frequent, selecting uncertain locations is more informative. The prior probability of the target was varied from 0.17 to 0.67 to determine whether observers adjusted their saccades strategies to maximize information. Observers actively searched a noisy display with six potential target locations. Each location had an independent probability of a target, so the number of targets in a trial ranged from 0 to 6. For all target priors ranging from low to high, a trial-by-trial analysis of saccade strategy indicated that observers made saccades to the most likely target location more often than the most uncertain location. Fixating likely locations is efficient only when multiple targets are rare, as in the case of a low target prior, or in the case of the more standard single-target search task. Yet it is the preferred saccade strategy in all our conditions, even when multiple targets are frequent. These findings indicate that humans are far from ideal searchers in multiple-target search. PMID:22929812

Verghese, Preeti

2012-12-01

319

Relationship of the Brief UCSD Performance-based Skills Assessment (UPSA-B) to multiple indicators of functioning in people with schizophrenia and bipolar disorder  

PubMed Central

Objective This study assessed the relationship between multiple indicators of ‘real-world’ functioning and scores on a brief performance-based measure of functional capacity known as the Brief University of California San Diego (UCSD) Performance-based Skills Assessment (UPSA-B) in a sample of 205 patients with either serious bipolar disorder (n = 89) or schizophrenia (n = 116). Methods Participants were administered the UPSA-B and assessed on the following functional domains: (i) independent living status (e.g., residing independently as head of household, living in residential care facility); (ii) informant reports of functioning (e.g., work skills, daily living skills); (iii) educational attainment and estimated premorbid IQ as measured by years of education and Wide Range Achievement Test reading scores, respectively; and (iv) employment. Results Better scores on the UPSA-B were associated with greater residential independence after controlling for age, diagnosis, and symptoms of psychopathology. Among both bipolar disorder and schizophrenia patients, higher UPSA-B scores were significantly related to better informant reports of functioning in daily living skills and work skills domains. Greater estimated premorbid IQ was associated with higher scores on the UPSA-B for both schizophrenia and bipolar disorder participants. Participants who were employed scored higher on the UPSA-B when controlling for age and diagnosis, but not when controlling for symptoms of psychopathology. Conclusions These data suggest the UPSA-B may be useful for assessing capacity for functioning in a number of domains in both people diagnosed with schizophrenia and bipolar disorder.

Mausbach, Brent T; Harvey, Philip D; Pulver, Ann E; Depp, Colin A; Wolyniec, Paula S; Thornquist, Mary H; Luke, James R; McGrath, John A; Bowie, Christopher; Patterson, Thomas L

2010-01-01

320

Daclizumab treatment for multiple sclerosis.  

PubMed

Multiple sclerosis is a chronic inflammatory and demyelinating disease of the central nervous system and the leading cause of neurologic disability in young adults. Established therapies, such as interferon and glatiramer, have only partial effects, and they offer limited or no effect on the progression of multiple sclerosis. The etiology of multiple sclerosis is unclear; however, the disease is presumed to be a T-cell-mediated autoimmune disease influenced by genetic and environmental factors. Therefore, targeting of lymphocytes may be a promising means of therapy for multiple sclerosis. Daclizumab is a humanized monoclonal antibody approved for use in preventing renal allograft rejection. The agent is under investigation in phase II trials for the treatment of multiple sclerosis and has demonstrated positive clinical outcomes, including decreased relapse rates. Adverse events included urinary tract infections, respiratory tract infections, paresthesias, mild leukopenia, transient elevations in liver enzyme and bilirubin levels, rash, postinfusion reactions (fever), lymphadenopathy, transient thrombocytopenia, and nausea. Daclizumab may be an alternative or add-on therapy when conventional immunomodulators fail or when existing approved therapies cannot be used. Besides ongoing phase II trials, additional phase II or III trials are required to determine the extended benefits of the agent, as well as clinical outcomes. PMID:19170591

Kim, Sylvia E

2009-02-01

321

Multiple sclerosis and herpesvirus interaction.  

PubMed

Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is that they have periods of latency and exacerbations within their biological sanctuary, the central nervous system. The Epstein-Barr, cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 viruses are the members that are most studied as being possible triggers of multiple sclerosis. According to evidence in the literature, the herpesvirus family is strongly involved in the pathogenesis of this disease, but it is unlikely that they are the only component responsible for its development. There are probably multiple triggers and more studies are necessary to investigate and define these interactions. PMID:24141514

Olival, Guilherme Sciascia do; Lima, Bruna Mendonça; Sumita, Laura M; Serafim, Vitor; Fink, Maria Cristina; Nali, Luis Henrique; Romano, Camila Malta; Thomaz, Rodrigo Barbosa; Cavenaghi, Vitor Breseghello; Tilbery, Charles Peter; Penalva-de-Oliveira, Augusto Cesar

2013-09-01

322

Hemichorea after multiple bee stings.  

PubMed

Bee sting is one of the most commonly encountered insect bites in the world. Despite the common occurrence of local and systemic allergic reactions, there are few reports of ischemic stroke after bee stings. To the best our knowledge, there have been no reports on involuntary hyperkinetic movement disorders after multiple bee stings. We report the case of a 50-year-old man who developed involuntary movements of the left leg 24 hours after multiple bee stings, and the cause was confirmed to be a right temporal infarction on a diffusion magnetic resonance imaging scan. Thus, we concluded that the involuntary movement disorder was caused by right temporal infarction that occurred after multiple bee stings. PMID:24268878

An, Jin Young; Kim, Ji Seon; Min, Jin Hong; Han, Kyu Hong; Kang, Jun Ho; Lee, Suk Woo; Kim, Hoon; Park, Jung Soo

2014-02-01

323

Multiple infected cerebral hydatid cysts.  

PubMed

We report an unusual patient with multiple infected cerebral hydatid cysts. A 20-year-old man presented with a 2-month history of headache and progressive left-sided hempiparesis. A cerebral CT scan showed a large and heterogeneous parieto-occipital lesion. During surgery an infected hydatid cyst was discovered with multiple daughter vesicles. Post-operatively the patient was treated with albendazol, cefotaxime and metronidazole. The clinical course was good with total recovery of the hemiparesis. A follow-up CT scan showed persistence of some small deep-seated cysts. Multiple infected cerebral hydatid cyst is uncommon and can be confused with other cystic brain lesions. The aim of surgery is to remove the cyst unruptured and this should be followed by antihelminthic and antibiotic treatment in order to avoid recurrences. PMID:18342511

Gana, R; Skhissi, M; Maaqili, R; Bellakhdar, F

2008-05-01

324

Active global localization for multiple robots by disambiguating multiple hypotheses  

Microsoft Academic Search

In environments which possess relatively few fea- tures that enable a robot to unambiguously determine its location, global localization algorithms can result in multiple hypotheses locations of a robot. In such a scenario the robot, for effective localization, has to be actively guided to those locations where there is a maximum chance of eliminating most of the ambiguous states -

Shivudu Bhuvanagiri; K. Madhava Krishna

2008-01-01

325

Multiple-Symbol Detection Of Multiple-Trellis-Coded MDPSK  

NASA Technical Reports Server (NTRS)

In proposed scheme for detection and decoding of multiple-trellis-coded multilevel differential-phase-shift-keyed (MDPSK) radio signals, observation time for differential detection extended from conventional 2 to larger number of symbol periods. Decreases rate of error in differential detection of uncoded MDPSK by increasing number of symbol periods.

Divsalar, Dariush; Simon, Marvin K.; Shahshahani, Mehrdad M.

1991-01-01

326

Complementary identification of multiple fluxdistributions and multiple metabolic pathways  

Microsoft Academic Search

Cell robustness and complexity have been recognized as unique features of biological systems. Such robustness and complexity of metabolic-reaction systems can be explored by discovering, or identifying, the multiple flux distributions (MFD) and redundant pathways that lead to a given external state; however, this is exceedingly cumbersome to accomplish. It is, therefore, highly desirable to establish an effective computational method

Dong-Yup Lee; L. T. Fan; Sang Yup Lee; Shahram Shafie; Botond Bertok; Ferenc Friedler

327

Convergence and Discriminant: Assessing Multiple Traits Using Multiple Methods  

ERIC Educational Resources Information Center

Multiple traits of language proficiency as well as test method effects were concurrently analyzed to investigate interrelations of construct validity, convergent validity, and discriminant validity using multitrait-multimethod (MTMM) matrices. A total of 585 test takers' scores were derived from the field test of the "Pearson Test of English…

Pae, Hye K.

2012-01-01

328

Joint Resource Allocation in Multiple Channels, Multiple Relays Systems  

Microsoft Academic Search

In this paper, we will study the joint problem of power allocation, relay selection and subchannel pairing in OFDM based amplify-and-forward multiple relays system. The optimization problem of maximizing system capacity under joint power constraint at source and relays is firstly formulated. Then, based on Lagrangian dual method, an optimal algorithm to the problem is derived with high SNR assumption.

Rui Yin; Yu Zhang; Jietao Zhang; Guanding Yu; Zhaoyang Zhang

2010-01-01

329

Dynamics of Multiple Stars: Observations  

NASA Astrophysics Data System (ADS)

The dynamics of hierarchical multiple stars is observed mostly by a combination of various techniques that lead to the determination of orbits. It is found that the empirical limit of dynamical stability matches the theoretical limit for circular outer orbits but is more restrictive for eccentric orbits. The relative orientation of orbits in triple stars shows some weak correlation, likely explained by their origin as decay products of small clusters. The combination of dynamics and tides leads to the formation of close binaries within higher-order multiples. Examples of such systems (Algol, Capella, 41 Dra) show that even distant tertiary components can significantly modify stellar evolution.

Tokovinin, A.

330

Goiter and Multiple Food Allergies  

PubMed Central

Severe iodine deficiency results in impaired thyroid hormone synthesis and thyroid enlargement. In the United States, adequate iodine intake is a concern for women of childbearing age and pregnant women. Beyond this high risk group iodine deficiency is not considered to be a significant problem. This case report describes a 12-year-old male with severe iodine deficiency disorder (IDD) resulting from restricted dietary intake due to multiple food allergies. We describe iodine replacement for this patient and continued monitoring for iodine sufficiency. Children with multiple food allergies, in particular those with restrictions to iodized salt and seafood, should be considered high risk for severe iodine deficiency.

Leniszewski, Stefanie; Mauseth, Richard

2009-01-01

331

Multiple trichoepitheliomas: A rare occurrence  

PubMed Central

Trichoepitelioma is an extremely rare cosmetically disfiguring condition usually affecting the females. Trichoepitheliomas are benign lesions seen on the face, which are thought to derive from the hair follicle. Malignant transformation to basal cell carcinoma is rare and occurs late in the course of the disease These lesions are often misinterpreted and diagnosed clinically as neurofibromatosis or histpathologically as basal cell carcinoma. We report a case of multiple trichoepithelioma occurring in a male patient. The patient presented with multiple dermatologic growths on the face with varied histopathological presentations which have been described in detail.

Karikal, Arvind; Shetty, Pushparaj; Karikal, Arathi; Shetty, Shishir R.

2013-01-01

332

Multiple Spontaneous Simultaneous Intracerebral Hemorrhages  

PubMed Central

Simultaneous occurrence of intracerebral hemorrhage (ICH) in different arterial territories is an uncommon event. We report on two cases of multiple spontaneous simultaneous ICH for which we could find no specific cause. A 73-year-old man, with no related medical history, was admitted to the hospital with simultaneous bithalamic ICH, and subsequently died of recurrent pneumonia. Second patient was a 60-year-old man who presented with simultaneous ICH in the pons and thalamus; he died of recurrent bleeding. We review the possible pathological mechanisms, clinical and radiologic features of simultaneous multiple ICH.

Seo, Jin-Suk; Nam, Taek-Kyun; Kwon, Jeong-Taik

2014-01-01

333

Multiple order common path spectrometer  

NASA Technical Reports Server (NTRS)

The present invention relates to a dispersive spectrometer. The spectrometer allows detection of multiple orders of light on a single focal plane array by splitting the orders spatially using a dichroic assembly. A conventional dispersion mechanism such as a defraction grating disperses the light spectrally. As a result, multiple wavelength orders can be imaged on a single focal plane array of limited spectral extent, doubling (or more) the number of spectral channels as compared to a conventional spectrometer. In addition, this is achieved in a common path device.

Newbury, Amy B. (Inventor)

2010-01-01

334

Multiple resonant railgun power supply  

DOEpatents

A multiple repetitive resonant railgun power supply provides energy for repetitively propelling projectiles from a pair of parallel rails. A plurality of serially connected paired parallel rails are powered by similar power supplies. Each supply comprises an energy storage capacitor, a storage inductor to form a resonant circuit with the energy storage capacitor and a magnetic switch to transfer energy between the resonant circuit and the pair of parallel rails for the propelling of projectiles. The multiple serial operation permits relatively small energy components to deliver overall relatively large amounts of energy to the projectiles being propelled.

Honig, Emanuel M. (Los Alamos, NM); Nunnally, William C. (Los Alamos, NM)

1988-01-01

335

Sequential Test Strategies for Multiple Fault Isolation  

NASA Technical Reports Server (NTRS)

In this paper, we consider the problem of constructing near optimal test sequencing algorithms for diagnosing multiple faults in redundant (fault-tolerant) systems. The computational complexity of solving the optimal multiple-fault isolation problem is super-exponential, that is, it is much more difficult than the single-fault isolation problem, which, by itself, is NP-hard. By employing concepts from information theory and Lagrangian relaxation, we present several static and dynamic (on-line or interactive) test sequencing algorithms for the multiple fault isolation problem that provide a trade-off between the degree of suboptimality and computational complexity. Furthermore, we present novel diagnostic strategies that generate a static diagnostic directed graph (digraph), instead of a static diagnostic tree, for multiple fault diagnosis. Using this approach, the storage complexity of the overall diagnostic strategy reduces substantially. Computational results based on real-world systems indicate that the size of a static multiple fault strategy is strictly related to the structure of the system, and that the use of an on-line multiple fault strategy can diagnose faults in systems with as many as 10,000 failure sources.

Shakeri, M.; Pattipati, Krishna R.; Raghavan, V.; Patterson-Hine, Ann; Kell, T.

1997-01-01

336

Interoperability of multiple autonomous databases  

Microsoft Academic Search

Database systems were a solution to the problem of shared access to heterogeneous files created by multiple autonomous applications in a centralized environment. To make data usage easier, the files were replaced by a globally integrated database. To a large extent, the idea was successful, and many databases are now accessible through local and long-haul networks. Unavoidably, users now need

Witold Litwin; Leo Mark; Nick Roussopoulos

1990-01-01

337

Cerebrospinal fluid in multiple sclerosis  

PubMed Central

Background: Technological advances have made it possible to examine the human cerebrospinal fluid (CSF) in a manner that was previously impossible. CSF provides a window into the changes that occur in the central nervous system (CNS) in health and disease. Through analysis of the CSF, we discern indirectly the state of health of the CNS, and correctly or incorrectly, draw conclusions regarding mechanisms of CNS injury and repair. Objective, Materials and Methods: To review the current state of knowledge of changes in the CSF in multiple sclerosis. Discussion: Establishing CSF markers that permit evaluation of the various biological processes in multiple sclerosis remains a challenge. Of all the biological processes, inflammatory markers are probably the best identified. Detection of oligoclonal immunoglobulin bands in the CSF is now established as the single most useful laboratory marker in the CSF to aid in the diagnosis of multiple sclerosis. Markers of demyelination, remyelination, neuro-axonal loss, neural repair and regeneration, and astrogliosis are only now being recognized. A good surrogate for any of these pathophysiological processes has not been defined to date. Conclusion: The goal of future research is not only to define surrogate markers in the CSF for each of the above functions, but also to extend it to other more readily accessible body fluids like blood and urine. A synopsis of the current literature in most of these areas of CSF evaluation pertaining to multiple sclerosis is presented in this article.

Rammohan, Kottil W.

2009-01-01

338

Multiple Literacies Theory: Exploring Futures  

ERIC Educational Resources Information Center

This article focuses on the contributions of philosophy, art and science to education through the conceptual, theoretical, and methodological usefulness of a Deleuze-Guattarian conceptual framework that informs multiple literacies theory (MLT). Education lends itself to Deleuze's notion of connecting and creating through philosophy, art and…

Masny, Diana

2011-01-01

339

Improving Multiple-Choice Questions  

ERIC Educational Resources Information Center

A MC (multiple-choice) question can be defined as a question in which students are asked to select one alternative from a given set of alternatives in response to a question stem. The objective of this paper is to analyse if MC questions may be considered as an interesting alternative for assessing knowledge, particularly in the mathematics area,…

Torres, Cristina; Lopes, Ana Paula; Babo, Lurdes; Azevedo, Jose

2011-01-01

340

Matrix Multiplication on Heterogeneous Platforms  

Microsoft Academic Search

In this paper, we address the issue of implementing matrix multiplication on heterogeneous platforms. We target two different classes of heterogeneous computing resources: heterogeneous networks of workstations and collections of heterogeneous clusters. Intuitively, the problem is to load balance the work with different speed resources while minimizing the communication volume. We formally state this problem in a geometric framework and

Olivier Beaumont; Vincent Boudet; Fabrice Rastello; Yves Robert

2001-01-01

341

Matrix multiplication via arithmetic progressions  

Microsoft Academic Search

We present a new method for accelerating matrix multiplication asymptotically. This work builds on recent ideas of Volker Strassen, by using a basic trilinear form which is not a matrix product. We make novel use of the Salem-Spencer Theorem, which gives a fairly dense set of integers with no three-term arithmetic progression. Our resulting matrix exponent is 2.376.

Don Coppersmith; Shmuel Winograd

1987-01-01

342

Parallel Complexity of Matrix Multiplication  

Microsoft Academic Search

Effective design of parallel matrix multiplication algorithms relies on the consideration of many interdependent issues based on the underlying parallel machine or network upon which such algorithms will be implemented, as well as, the type of methodology utilized by an algorithm. In this paper, we determine the parallel complexity of multiplying two (not necessarily square) matrices on parallel distributed-memory machines

Eunice E. Santos

2003-01-01

343

Improving Inferences from Multiple Methods.  

ERIC Educational Resources Information Center

Multiple evaluation methods (MEMs) can cause an inferential challenge, although there are strategies to strengthen inferences. Practical and theoretical issues involved in the use by social scientists of MEMs, three potential problems in drawing inferences from MEMs, and short- and long-term strategies for alleviating these problems are outlined.…

Shotland, R. Lance; Mark, Melvin M.

1987-01-01

344

Online multiple support instance tracking  

Microsoft Academic Search

We propose an online tracking algorithm in which the support instances are selected adaptively within the multiple instance learning framework. The support instances are selected from training 1-norm support vector machines in a feature space, thereby learning large margin classifiers for visual tracking. An algorithm is presented to update the support instances by taking image data obtained previously and recently

Qiu-Hong Zhou; Huchuan Lu; Ming-Hsuan Yang

2011-01-01

345

Real Multiplication and noncommutative geometry  

Microsoft Academic Search

Classical theory of Complex Multiplication (CM) shows that all abelian extensions of a complex quadratic field $K$ are generated by the values of appropriate modular functions at the points of finite order of elliptic curves whose endomorphism rings are orders in $K$. For real quadratic fields, a similar description is not known. However, the relevant (still unproved) case of Stark

Yuri I. Manin

2002-01-01

346

Multiple Sclerosis and Vitamin D  

MedlinePLUS

... 10.1212/WNL.0b013e318237c282 2011;77;e99-e100 Neurology Andrew J. Solomon Multiple sclerosis and vitamin D ... current as of October 24, 2011 http://www.neurology.org/content/77/17/e99.full.html located ...

347

Fungible Weights in Multiple Regression  

ERIC Educational Resources Information Center

Every set of alternate weights (i.e., nonleast squares weights) in a multiple regression analysis with three or more predictors is associated with an infinite class of weights. All members of a given class can be deemed "fungible" because they yield identical "SSE" (sum of squared errors) and R[superscript 2] values. Equations for generating…

Waller, Niels G.

2008-01-01

348

Learning Multiplication: The Easy Way  

ERIC Educational Resources Information Center

In this article, the author presents an innovative approach to teaching multiplication facts for children in middle school or younger. After introducing the dangers of some contradictions that persist, relating a brief summary of related research and guidelines regarding math facts and their relation to strategic approaches to more complex math,…

Caron, Thomas A.

2007-01-01

349

Multiple Grating Spectrometer Resolving Power.  

National Technical Information Service (NTIS)

The resolution for multiple grating spectrometers is obtained using the transfer function formalism. It is shown that the limiting resolving power for a system of n equal gratings in additive dispersion lambda/Delta lambda sub g (n) is overestimated by pr...

V. Mazzacurati, G. Ruocco, G. Signorelli

1988-01-01

350

Theory of Multiple Leaky Aquifers  

Microsoft Academic Search

This paper is an extension of previous work by Herrera and Figueroa to multiple leaky aquifers. The equations governing the motion of such systems are transformed to obtain a simpler system suitable for numerical treatment. An essential feature of the method is the introduction of a lag time that occurs because the influence of any aquifer is not transmitted instant1~

Ismael Herrera

1970-01-01

351

Multiple view analysis of designs  

Microsoft Academic Search

During design formulation, designs are subjected to an evaluation and verificationprocess, the goal of which is the detection of design errors. The analysis of differentdesigns or "views" using different design notations has been proposed to achieve thisgoal. The formal support for the use of multiple views at the design stage with the purposeto detect design discrepancies has been provided by

Boumediene Belkhouche; Cuauhtémoc Lemus Olalde

1996-01-01

352

Fall detection using multiple cameras  

Microsoft Academic Search

Today, different ways are suggested to help elderly people in case of emergency. Our aim here is to propose a novel method, without any wearable device, to detect falls on the floor with a multiple cameras system. This proposal uses image analysis to localise people and reconstruct their 3D shape and position. The particularity of this contribution is the use

Edouard Auvinet; Lionel Reveret; Alain St-Arnaud; Jacqueline Rousseau; Jean Meunier

2008-01-01

353

Occupational therapy for multiple sclerosis  

Microsoft Academic Search

Background: Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration of upper extremity fine motor coordination, loss of sensation and spasticity that causes limitations in performance of activities of daily living and social participation. The primary purpose of occupational therapy is to enable individuals to participate in self-care, work and leisure activities that

E. M. J. Steultjens; J. Dekker; L. M. Bouter; M. Cardol; J. C. M. van de Nes; C. H. M. van den Ende

2003-01-01

354

Multiple Intelligences Theory in Action.  

ERIC Educational Resources Information Center

The two articles in this newsletter issue focus on and discuss the multiple intelligences (MI) theory and its application in schools. Developed by Howard Gardner at Harvard University, the theory argues that individuals differ in their abilities, learning styles, and interests, and that these differences need to be acknowledged and nurtured in…

Lockwood, Anne Turnbaugh

1993-01-01

355

Low Cost Multiple Round Launcher.  

National Technical Information Service (NTIS)

A multiple round rocket launcher comprised of a honeycomb construction with each tube having a hexagonal cross-section. Metal sheets are formed into a semi-hexagonal cross-sectional configuration with a flat section between each semi-hexagonal section. A ...

H. R. Oswell

1979-01-01

356

AN OVERVIEW OF MULTIPLE IMPUTATION  

Microsoft Academic Search

Multiple imputation for nonresponse in public-use files replaces each missing value by two or more plausible values. The values can be chosen to represent both uncertainty about which values to impute assuming the reasons for nonresponse are known and uncertainty about the reasons for nonresponse. The theoretical underpinnings and several examples are given in Rubin (1987). Thispresentation illustrates the dramatic

Donald B. Rubin

357

Overhearing Single and Multiple Perspectives  

ERIC Educational Resources Information Center

In 2 spontaneous speech experiments, this study found that multiple perspectives improved overhearers' abilities to select abstract shapes from an array, although single-perspective descriptions were more detailed. Prior findings that overhearers performed better when listening in on dialogues (Fox Tree, 1999) can best be understood as an…

Fox Tree, Jean E.; Mayer, Sarah A.

2008-01-01

358

Cognitive rehabilitation in multiple sclerosis  

Microsoft Academic Search

There are few reports of cognitive rehabilitation, possibly because of the enigmatic nature of cognitive dysfunction in multiple sclerosis (MS) and also the lack of consensus relating to assessment, intervention and experimental design. These aspects are discussed in relation to clinical practice and two recent studies.

D. W. Langdon

1998-01-01

359

Developmental thermography: multiple aspect thermography  

Microsoft Academic Search

Multiple aspect thermography (MAT) is a kind of developmental thermography. MAT was designed in order to supplement the shortage of the number of coverage aspects in triple aspect thermography (TAT). TAT allows simultaneous display of numbers of thermograms on various selected aspects of the subject in CRT frame. This paper reports on MAT methodology and discusses some aspects of the

Akinori Nagasawa; Kazuichi Katoh

1993-01-01

360

Natural history of multiple meningiomas  

PubMed Central

Background: Asymptomatic solitary meningiomas are typically managed with clinical and radiographic follow-up. Multiple meningiomas represents a clinical entity distinct from solitary meningiomas and can be sporadic, radiation-induced, associated with neurofibromatosis, or exhibit other familial inheritance. The growth rate for multiple meningiomas is not known and therefore management of these complicated patients can be difficult. Methods: A retrospective chart review was performed on 12 patients with a total of 55 meningiomas. Patients with neurofibromatosis were not included. Serial enhanced magnetic resonance imaging was used to determine tumor growth rates. Treatment history was also reviewed and included for analysis. Results: Analysis of all 55 tumors demonstrated an average rate of growth of 0.46 cm3/year (range: ?0.57-2.94 cm3/year). In the 23 tumors that received no treatment, the average rate of growth was 0.34 cm3/year (range: ?0.03-1.8 cm3/year). Ten of the 23 tumors that received no treatment had no history of cranial irradiation. This group demonstrated a growth rate of 0.44 cm3/year (range: ?0.01-1.8 cm3/year). Linear regression analysis did not yield any significant relationship between tumor burden and rates of growth. Conclusion: Tumor growth rates in patients with multiple meningiomas did not appear to be higher than reported rates for incidentally found solitary meningiomas. As such, asymptomatic multiple meningioma patients should be managed with clinical and radiographic follow-up.

Wong, Ricky H.; Wong, Andrew K.; Vick, Nicholas; Farhat, Hamad I.

2013-01-01

361

Multiple Exceptionalities: A Case Study.  

ERIC Educational Resources Information Center

This case study reports on an 11-year-old boy with multiple exceptionalities. The child was verbally gifted, learning disabled in mathematics, and health impaired. He had received homebound instruction throughout his elementary school years. Qualitative research methods were used to explore the subject's learning characteristics and educational…

Moon, Sidney M.; Dillon, Deborah R.

1995-01-01

362

Multiple Pathways for All Students  

ERIC Educational Resources Information Center

Maine has been focusing on the importance of postsecondary training. Maine's Skowhegan Area High School (SAHS) and Somerset Career and Technical Center (SCTC) have partnered in a Multiple Pathways initiative (funded by the Nellie Mae Education Foundation) to increase students' high school completion rate and to increase enrollment in postsecondary…

Stirling, Lee Anna

2012-01-01

363

[Paroxysmal phenomena in multiple sclerosis].  

PubMed

The different types and common features of paroxysmal attacks are illustrated by three case reports. The main cause for these attacks is multiple sclerosis, but the mechanism is still unknown: ephaptic activation of demyelinated neurons is discussed. "Anticonvulsive therapy" leads to cessation of the attacks. PMID:3932890

Bleistein, J; Jerusalem, F

1985-08-01

364

The ALICE Forward Multiplicity Detector  

NASA Astrophysics Data System (ADS)

The ALICE Forward Multiplicity Detector (FMD) is a silicon strip detector with 51,200 strips arranged in 5 rings, covering the range -3.4 < ? < 5.1. It is placed around the beam pipe at small angles to extend the charged particle acceptance of ALICE into the forward regions, not covered by the central barrel detectors.

Christensen, Christian Holm; Gaardhøje, Jens Jørgen; Gulbrandsen, Kristján; Nielsen, Børge Svane; Søgaard, Carsten

365

Becoming a Multiple Intelligences School.  

ERIC Educational Resources Information Center

The motivation to help students learn has moved many educators to explore multiple intelligences (MI) theory as a tool to help more children succeed. This book relates a decade of experiences in applying MI theory at New City School, an independent St. Louis elementary school. Directed toward educational leaders, the book focuses on the centrality…

Hoerr, Thomas R.

366

Symptomatic Treatment of Multiple Sclerosis  

Microsoft Academic Search

Besides immunomodulation and immunosuppression, the specific treatment of symptoms is an essential component of the overall management of multiple sclerosis (MS). Symptomatic treatment is aimed at the elimination or reduction of symptoms impairing the functional abilities and quality of life of the affected patients. Moreover, with symptomatic treatment the development of a secondary physical impairment due to an existing one

T. Henze; P. Rieckmann; K. V. Toyka

2006-01-01

367

Presentation 7: Multiple Primary Rules  

Cancer.gov

MP Rules - Note 2 The registrar must recognize that during the diagnostic workup the physician may start with a non-specific diagnosis (NOS) and as testing is completed, a more specific histology is identified. These diagnoses are not multiple primaries; they represent steps in the diagnostic work-up. See rules M7-M12.

368

Bronchogenic cyst with multiple complications  

Microsoft Academic Search

Bronchogenic cysts are a rare type of mediastinal mass thought to arise from abnormal budding of the embryologic foregut. This paper presents a rare case of a 32-year-old male who developed multiple serious complications from a bronchial cyst. This rare presentation is discussed and the role of CT and MR imaging in making the diagnosis is highlighted. © 2007 Biomedical

G Marshall; C Cheah; NP Lenzo

2007-01-01

369

Investigations on Multiplication of Fractions.  

ERIC Educational Resources Information Center

Three different models with continuous materials, discontinuous materials, and number lines were used to study the operation concept in six investigations on multiplication with fractions with pupils aged 11-12 in a Penang International School. All approaches could be understood by pupils, but they preferred the area and fractional models. (MNS)

Sai, Khoo Phon; Inder, Walter R. D.

1984-01-01

370

Cerebral palsy and multiple births  

Microsoft Academic Search

AIM: To compare the birthweight specific prevalence of cerebral palsy in singleton and multiple births. METHODS: Registered births of babies with cerebral palsy born to mothers resident in the counties of Merseyside and Cheshire during the period 1982 to 1989 were ascertained. RESULTS: The crude prevalence of cerebral palsy was 2.3 per 1000 infant survivors in singletons, 12.6 in twins,

P O Pharoah; T Cooke

1996-01-01

371

Interferon Treatment of Multiple Sclerosis  

PubMed Central

Introduction: In the treatment of Multiple Sclerosis (MS) differ: treatment of relapse, treatment slow the progression of the disease (immunomodulators and immunosuppression), and symptomatic treatment. The aim: The aim of this study is to analyze the application of interferon therapy in the treatment of MS-E: Process the disease, patients with multiple sclerosis who have passed the commission for multiple sclerosis at the Neurology Clinic of Clinical Center of Sarajevo University as a reference center for referral to the Commission for multiple sclerosis from the Federal Ministry of Health in 2009 year in terms of total number examined, gender differences, diagnostic tests (MRI, CSF, EP), neurological findings and EDSS scores. Provide a section through the continuous support and education of patients during the introduction Betaferon in therapy with the goal of education for self-use and reduce the incidence of side effects of interferon therapy. Materials and methods: The material for the work they were histories of patients who are registered as patients who have undergone a commission for MS at Department of Neurology, University Clinical Center in Sarajevo. The evaluation was retrospective. It was used a specially designed form, which is usually applied to patients referred to this committee. After the collected material was carried out data processing. The study comprised 34 patients who have undergone a commission of which 16 patients received interferon therapy. Results: In 2009 at the Neurology Clinic CCUS have treated 34 patients who passed the committee for recommendation to interferon therapy (25 women and 9 men). The diagnosis of multiple sclerosis is safe based on the criteria of international panel in 2000. EDSS Average score for men was 1.8, 1.9 for women, the total EDSS score was 1.8. The gender ratio is 3:1 in women than in men. Sixteen patients received interferon by the Commission for multiple sclerosis, the Federal Ministry of Health and their therapy was initiated at the clinic. Conclusion: For the period of 2009, a total of 34 patients were examined with multiple sclerosis who received interferon treatment recommendations at the expense of the Federal Solidarity Fund at the Neurology Clinic CCUS Sarajevo. The average EDSS score was 1.8. There were no significant differences in neurological findings between patients who were previously treated with interferon and patients who were waiting for treatment.

Alajbegovic, Azra; Deljo, Dervis; Alajbegovic, Salem; Djelilovic-Vranic, Jasminka; Todorovic, Ljubica; Tiric-Campara, Merita

2012-01-01

372

On the Time Required to Perform Multiplication  

Microsoft Academic Search

The time required to perform multiplication is investigated. A lower bound on the time required to perform multiplication, as well as multiplication modulo N, is derived and it is shown that these lower bounds can be approached. Then a lower bound on the amount of time required to perform the most significant part of multiplication (⌞xy\\/N⌟) is derived.

Shmuel Winograd; Yorktown Heights

1967-01-01

373

Stable isotope values (?18O & ?13C) of multiple ostracode species in a large Neotropical lake as indicators of past changes in hydrology  

NASA Astrophysics Data System (ADS)

Modern lake hydrodynamics, ostracode species autecology, stable isotopes (?18O and ?13C) of multiple ostracode species, ostracode taphonomy and sediment geochemistry were studied to improve interpretation of the late Pleistocene-early Holocene (˜24-10 ka) stable isotope record of ostracodes in sediment core PI-6 from Lago Petén Itzá, northern Guatemala. Oxygen and carbon stable isotopes in modern and fossil species assemblages of Lago Petén Itzá were used as indicators of changes in the balance between evaporation and precipitation, past lake level and carbon source. Ostracode taphonomy was used to detect past periods of strong currents, high-energy environments, and possible partial or full mixing of the lake. The modern lake water isotopic composition displays clear seasonal differences that are independent of lake level fluctuations. Modern benthic species displayed lower ?18O and ?13C values than nektobenthic species, with differences of 3.0‰ and 5.3‰, respectively. Valves of nektobenthic species display higher values of ?13C because these ostracodes live in shallower environments among abundant algae and aquatic plants, where productivity is high. The benthic species Limnocythere opesta Brehm, 1939 displayed the smallest average offset from ?18O water (+0.3‰) and the largest offset from ?13CDIC values (-4.1‰) among studied ostracode species. Nektobenthic species Heterocypris punctata Keyser, 1975 displayed the smallest difference relative to the ?13CDIC values (-0.1‰). Late Pleistocene-early Holocene climate conditions and water levels in Lago Petén Itzá can be summarized as follows: 1) high lake levels and cold conditions (Last Glacial Maximum [LGM], ˜24-19 ka), 2) fluctuating lake levels and cold conditions (Heinrich Stadial 1 [HS1], ˜19-15 ka), 3) high lake levels and warm and wetter conditions (Bølling-Allerød [BA], ˜15-13 ka), 4) low lake levels and dry conditions (Younger Dryas [YD], ˜13-11.5 ka) and 5) high lake levels and warm and wetter conditions (early Holocene, ˜11.5-10.0 ka). Average lake level fluctuation in Lago Petén Itzá during the late Pleistocene-early Holocene was as much as ˜25 m. Ostracode analyses suggest that the LGM was characterized by relatively low ?18O (+4.7 to +6.0‰), and ?13C values (-7.1 to -6.4‰) in ostracode valves, high inferred water depths and high percentages of broken adult and juvenile valves (>66%), suggesting a high-energy environment, strong currents, partial to full mixing, downslope transport, colder water temperatures and wetter conditions. An increase in the relative abundance of the benthic species L. opesta and higher numbers of broken valves suggest heavy precipitation events during the LGM (˜23.7, 21.7, 20.8 and 20.1 ka). HS1 was predominantly dry, but we identified times when lake levels were slightly higher, at the onset of the deglacial and a brief period (˜17-16 ka) between HS1b and HS1a. All studied climate proxies indicate wetter and warmer conditions and lake system stability during the BA. Lake levels dropped during the YD and gradually increased during the Preboreal and early Holocene. We demonstrate that modern and fossil ostracode isotopic signatures, species assemblages and taphonomy can be used together with physical and geochemical variables in Lago Petén Itzá sediments to make high-resolution inferences about late Pleistocene-early Holocene environmental changes in the lowland Neotropics.

Pérez, Liseth; Curtis, Jason; Brenner, Mark; Hodell, David; Escobar, Jaime; Lozano, Socorro; Schwalb, Antje

2013-04-01

374

Demand Characteristics of Multiple-Choice Items.  

ERIC Educational Resources Information Center

Thirteen graduate students were asked to indicate for each of 24 multiple-choice items whether the item tested "recall of specific information," a "higher order skill," or "don't know." The students were also asked to state their general basis for judging the items. The 24 items had been previously classified according to Bloom's cognitive-skills…

Diamond, James J.; Williams, David V.

375

Multiple-Correlation Functions and Scaling Laws.  

National Technical Information Service (NTIS)

The form of the multiple-correlation function in the Ornstein-Zernike approximation is investigated. As a result it is suggested that the index v, which describes the behavior of correlations in the critical region, is not determined by the indices which ...

C. Domb

1968-01-01

376

Multiple spiral patterns in a cardiac tissue  

NASA Astrophysics Data System (ADS)

Ventricular fibrillation (VF) is the major cause of sudden cardiac death, the leading cause of death in the industrialized world. However, the mechanisms for its onset are still not well understood. Recent experiments indicate that VF is induced by transitions of cardiac electric propagationg waves from a single spiral wave to multiple waves. To further understand the underlying mechanism of VF, we investigated the interaction between two waves in a two-dimensional excitable media. Three types of multiple spirals including multi-arm spirals have been found depending on the rotation direction and the distance among spiral waves.

Bai, Zhanguo; Li, Xia

2009-11-01

377

PPAR-?: Therapeutic Potential for Multiple Sclerosis  

PubMed Central

The role of peroxisome proliferator-activated receptors (PPARs) in altering lipid and glucose metabolism is well established. More recent studies indicate that PPARs also play critical roles in controlling immune responses. We and others have previously demonstrated that PPAR-? agonists modulate the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This review will discuss the cellular and molecular mechanisms by which these agonists are believed to modulate disease. The therapeutic potential of PPAR-? agonists in the treatment of multiple sclerosis will also be considered.

Drew, Paul D.; Xu, Jihong; Racke, Michael K.

2008-01-01

378

Multiplicity distributions and charged-neutral fluctuations  

NASA Astrophysics Data System (ADS)

We discuss the importance of event-by-event fluctuations in relativistic heavy-ion collisions. We present results of multiplicity fluctuations of photons and charged particles produced in 158.A GeV Pb+Pb collisions at CERN-SPS. Multiplicity fluctuations agree with participant model calculations indicating the absence of critical fluctuation. Localized fluctuations in charged particles to photons have been analyzed and compared to various mixed events. The results show localized fluctuations in both charged particles and photons. However, no correlated DCC-like fluctuation is observed. .

Nayak, Tapan K.; Aggarwal, M. M.; Angelis, A. L. S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T. C.; Baba, P. V. K. S.; Badyal, S. K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K. B.; Bhatia, V. S.; Blume, C.; Bucher, D.; Bü, Sching, H.; Carlé, N., L.; Chattopadhyay, S.; Decowski, M. P.; Delagrange, H.; Donni, P.; Dubey, A. K.; Majumdar, M. R. Dutta; El Chenawi, K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M. S.; Garpman, S.; Gavrishchuk, O.; Geurts, F. J. M.; Ghosh, T. K.; Glasow, R.; Guskov, B.; Gustafsson, H. A.?.; Gutbrod, H. H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Karadjev, K.; Karpio, K.; Kolb, B. W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Lö, Hner, H.; Luquin, L.; Mahapatra, D. P.; Manko, V.; Martin, M.; Martínez, G.; Maximov, A.; Miake, Y.; Mishra, G. C.; Mohanty, B.; Mora, M.-J.; Morrison, D.; Mukhanova, T.; Mukhopadhyay, D. S.; Naef, H.; Nandi, B. K.; Nayak, S. K.; Nayak, T. K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Plasil, F.; Pinganaud, W.; Purschke, M. L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N. K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J. M.; Sambyal, S. S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.-R.; Schutz, Y.; Shabratova, G.; Shah, T. H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B. C.; Slavine, N.; Söderström, K.; Sood, G.; Sørensen, S. P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; Pijll, E. C. V. D.; Eijndhoven, N. V.; Nieuwenhuizen, G. J. V.; Vinogradov, A.; Viyogi, Y. P.; Vodopianov, A.; Vörös, S.; Wys?ouch, B.; Wa98 Collaboration

2002-04-01

379

Multiple states in river and lake ecosystems.  

PubMed Central

Nonlinear models of ecosystem dynamics that incorporate positive feedbacks and multiple, internally reinforced states have considerable explanatory power. However, linear models may be adequate, particularly if ecosystem behaviour is primarily controlled by external processes. In lake ecosystems, internal (mainly biotic) processes are thought to have major impacts on system behaviour, whereas in rivers, external (mainly physical) factors have traditionally been emphasized. We consider the hypothesis that models that exhibit multiple states are useful for understanding the behaviour of lake ecosystems, but not as useful for understanding stream ecosystems. Some of the best-known examples of multiple states come from lake ecosystems. We review some of these examples, and we also describe examples of multiple states in rivers. We conclude that the hypothesis is an oversimplification; the importance of physical forcing in rivers does not eliminate the possibility of internal feedbacks that create multiple states, although in rivers these feedbacks are likely to include physical as well as biotic processes. Nonlinear behaviour in aquatic ecosystems may be more common than current theory indicates.

Dent, C Lisa; Cumming, Graeme S; Carpenter, Stephen R

2002-01-01

380

Mapping multiplicative to additive noise  

NASA Astrophysics Data System (ADS)

The Langevin formulation of a number of well-known stochastic processes involves multiplicative noise. In this work we present a systematic mapping of a process with multiplicative noise to a related process with additive noise, which may often be easier to analyse. The mapping is easily understood in the example of the branching process. In a second example we study the random neighbour (or infinite range) contact process which is mapped to an Ornstein–Uhlenbeck process with absorbing wall. The present work might shed some light on absorbing state phase transitions in general, such as the role of conditional expectation values and finite size scaling, and elucidate the meaning of the noise amplitude. While we focus on the physical interpretation of the mapping, we also provide a mathematical derivation.

Rubin, Katy J.; Pruessner, Gunnar; Pavliotis, Grigorios A.

2014-05-01

381

Chordomas Involving Multiple Neuraxial Bones  

PubMed Central

We present a patient with multifocal symptomatic osseous chordomas having unusual growth patterns with review of the pertinent literature. The patient was 62-year-old male and had multiple osseous chordomas located in sacral, thoracic, and paraclival jugular foramen areas. There was no metastasis in other organs. All affected sites were osseous. The multicentric chordomas are extremely rare. This case could be considered as a chordoma involving multiple neuraxial bones. But, the possibility of multicentricity could also be thought. In such cases radical resection should be performed for each lesion at the initial diagnosis. If complete surgical resections are infeasible or impossible, preoperative or postoperative radiation therapy should be planned for the highest possibility of successful treatment.

Lim, Jae Joon; Cho, Ki Hong; Yoon, Do Heum; Kim, Se Hoon

2009-01-01

382

Congenital and multiple hobnail hemangiomas.  

PubMed

Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typically occurring in young or middle-aged persons. It is usually apparent as a small solitary lesion. However, multiple lesions are identified sometimes. Herein, we report two cases of hobnail hemangioma in 7-year-old and 15-year-old males. Of note, the former case had a congenital lesion and the latter, multiple acquired lesions, which are both rare atypical presentations of the disease. PMID:22148030

Yoon, So Young; Kwon, Hyuck Hoon; Jeon, Hye Chan; Lee, Jong Hee; Cho, Soyun

2011-11-01

383

Multiple Exciton Generation Solar Cells  

SciTech Connect

Heat loss is the major factor limiting traditional single junction solar cells to a theoretical efficiency of 32%. Multiple Exciton Generation (MEG) enables efficient use of the solar spectrum yielding a theoretical power conversion efficiency of 44% in solar cells under 1-sun conditions. Quantum-confined semiconductors have demonstrated the ability to generate multiple carriers but present-day materials deliver efficiencies far below the SQ limit of 32%. Semiconductor quantum dots of PbSe and PbS provide an active testbed for developing high-efficiency, inexpensive solar cells benefitting from quantum confinement effects. Here, we will present recent work of solar cells employing MEG to yield external quantum efficiencies exceeding 100%.

Luther, J. M.; Semonin, O. E.; Beard, M. C.; Gao, J.; Nozik, A. J.

2012-01-01

384

Glucocorticoid receptor in multiple myeloma.  

PubMed

Glucocorticoid receptor levels of myeloma cells were quantitated in 7 patients with multiple myeloma. In 4 patients, glucocorticoid receptor levels were less than 10 fmol/10(6) cells. In 3 patients, receptor levels were from 17.6 to 21.4 fmol/10(6) cells. We further examined the correlation between glucocorticoid receptor levels and effect of dexamethasone on 14C-thymidine incorporation and cell viability using 2 myeloma cell lines, OPM-1 and OPM-2, established from a patient with multiple myeloma. Glucocorticoid receptor levels of OPM-1 and OPM-2 were 8.5 fmol/10(6) cells and 63.2 fmol/10(6) cells, respectively. The sensitivity of OPM-1 to dexamethasone in these studies was lower than that of OPM-2. These results suggest the possibility that the low level of glucocorticoid receptor in myeloma cells may be important for predicting a poor response to glucocorticoid therapy. PMID:3653372

Murakami, T; Togawa, A; Satch, H; Katoh, M; Imamura, Y; Ohsawa, N; Takaku, F

1987-07-01

385

Axonal Damage in Multiple Sclerosis  

PubMed Central

Multiple sclerosis is a debilitating disease of the central nervous system that has been characteristically classified as an immune-mediated destruction of myelin, the protective coating on nerve fibers. Although the mechanisms responsible for the immune attack to central nervous system myelin have been the subject of intense investigation, more recent studies have focused on the neurodegenerative component, which is cause of clinical disability in young adults and appears to be only partially controlled by immunomodulatory therapies. Here, we review distinct, but not mutually exclusive, mechanisms of pathogenesis of axonal damage in multiple sclerosis patients that are either consequent to long-term demyelination or independent from it. We propose that the complexity of axonal degeneration and the heterogeneity of the underlying pathogenetic mechanisms should be taken into consideration for the design of targeted therapeutic intervention.

Haines, Jeffery D.; Inglese, Matilde; Casaccia, Patrizia

2011-01-01

386

Sense-making and Multiplication  

NSDL National Science Digital Library

In this 14-minute video UK teacher Sally Hill uses patterns to help her students learn the multiples of four and understand how to apply that knowledge to more complex multi-digit problems. Head teacher Kate Frood discusses the school's guiding principles and her own style of leadership. The page includes a link to a pdf document summarizing K-4 Mental Math Strategies [cataloged separately].

2012-01-01

387

Multiple-gate SOI MOSFETs  

Microsoft Academic Search

In an ever increasing need for higher current drive and better short-channel characteristics, silicon-on-insulator MOS transistors are evolving from classical, planar, single-gate devices into three-dimensional devices with multiple gates (double-, triple- or quadruple-gate devices). The evolution and the properties of such devices are described and the emergence of a new class of MOSFETs, called triple-plus (3+)-gate devices offer a practical

Jean-Pierre Colinge

2004-01-01

388

Multiple Vaccinations: Friend or Foe  

PubMed Central

Few immunotherapists would accept the concept of a single vaccination inducing a therapeutic anti-cancer immune response in a patient with advanced cancer. But what is the evidence to support the “more-is-better” approach of multiple vaccinations? Since we are unaware of trials comparing the effect of a single vaccine versus multiple vaccinations on patient outcome, we considered that an anti-cancer immune response might provide a surrogate measure of the effectiveness of vaccination strategies. Since few large trials include immunological monitoring, the majority of information is gleaned from smaller trials in which an evaluation of immune responses to vaccine or tumor, before and at one or more times following the first vaccine was performed. In some studies there is convincing evidence that repeated administration of a specific vaccine can augment the immune response to antigens contained in the vaccine. In other settings multiple vaccinations can significantly reduce the immune response to one or more targets. Results from three large adjuvant vaccine studies support the potential detrimental effect of multiple vaccinations as clinical outcomes in the control arms were significantly better than that for treatment groups. Recent research has provided insights into mechanisms that are likely responsible for the reduced responses in the studies noted above, but supporting evidence from clinical specimens is generally lacking. Interpretation of these results is further complicated by the possibility that the dominant immune response may evolve to recognize epitopes not present in the vaccine. Nonetheless, the FDA-approval of the first therapeutic cancer vaccine and recent developments from preclinical models and clinical trials provide a substantial basis for optimism and a critical evaluation of cancer vaccine strategies.

Church, Sarah E.; Jensen, Shawn M.; Twitty, Chris; Bahjat, Keith; Hu, Hong-Ming; Urba, Walter J.; Fox, Bernard A.

2013-01-01

389

Artifactual hypercalcemia in multiple myeloma  

SciTech Connect

A calcium-binding IgG K monoclonal protein in a patient with multiple myeloma and asymptomatic hypercalcemia was recognized, isolated, and characterized. In addition to binding by the whole IgG molecules, calcium was bound by purified Fab fragments and recombined heavy and light chains. In a competitive binding study, the isolated myeloma protein did not bind magnesium. Recognition of calcium-binding myeloma proteins is important in order to avoid therapy for hypercalcemia.

Annesley, T.M.; Burritt, M.F.; Kyle, R.A.

1982-09-01

390

Fractional Dynamics at Multiple Times  

NASA Astrophysics Data System (ADS)

A continuous time random walk (CTRW) imposes a random waiting time between random particle jumps. CTRW limit densities solve a fractional Fokker-Planck equation, but since the CTRW limit is not Markovian, this is not sufficient to characterize the process. This paper applies continuum renewal theory to restore the Markov property on an expanded state space, and compute the joint CTRW limit density at multiple times.

Meerschaert, Mark M.; Straka, Peter

2012-11-01

391

FRACTIONAL DYNAMICS AT MULTIPLE TIMES.  

PubMed

A continuous time random walk (CTRW) imposes a random waiting time between random particle jumps. CTRW limit densities solve a fractional Fokker-Planck equation, but since the CTRW limit is not Markovian, this is not sufficient to characterize the process. This paper applies continuum renewal theory to restore the Markov property on an expanded state space, and compute the joint CTRW limit density at multiple times. PMID:23378670

Meerschaert, Mark M; Straka, Peter

2012-11-01

392

CHARGED PARTICLE MULTIPLICITIES AT BRAHMS.  

SciTech Connect

This report presents the measurement of charged particle multiplicity densities dN/d{eta} in ultrarelativistic heavy ion collisions as function of {eta} and the centrality of the collisions. This distributions were extracted from data collected by the BRAHMS collaboration during the first RHK run with gold ions at {radical}s{sub NN} = 130A {center_dot} GeV. The analysis method is described and, results are compared to some model predictions.

DEBBE, R., FOR THE BRAHMS COLLABORATION

2001-07-30

393

Matrix Multiplication via Arithmetic Progressions  

Microsoft Academic Search

We present a new method for accelerating matrix multiplication asymptotically. This work builds on recent ideas of Volker Strassen,by using a basic trilinear form which is not a matrix product. We make novel use of the Salem-Spencer Theorem, which gives a fairly dense set of integers with no three-term arithmetic progression. Our resulting matrix exponent is 2.376.

Don Coppersmith; Shmuel Winograd

1990-01-01

394

Melanoma Multiple Primary Rules Matrix  

Cancer.gov

Cutaneous Melanoma Multiple Primary Rules – Matrix C440 – C449 (Excludes melanoma of any other site) * P r e p ar e o n e abs tr a c t. U s e t h e hi s t o lo g y c o di ng r u le s t o as s i gn th e ap pr o p r iat e h is to lo

395

Colon Multiple Primary Rules Matrix  

Cancer.gov

Colon Multiple Primary Rules – Matrix C180-C189 (Excludes lymphoma and leukemia M9590 – 9989 and Kaposi sarcoma M9140) * P r e p ar e o n e abs tr a c t. U s e t h e hi s t o lo g y c o di ng r u le s t o as s i gn th e ap pr o p

396

Kidney Multiple Primary Rules Matrix  

Cancer.gov

Kidney Multiple Primary Rules – Matrix C649 (Excludes lymphoma and leukemia M9590 – 9989 and Kaposi sarcoma M9140) * P r e p ar e o n e abs tr a c t. U s e t h e hi s t o lo g y c o di ng r u le s t o as s i gn th e ap pr o p r iat

397

Multiple target laser ablation system  

DOEpatents

A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

Mashburn, D.N.

1996-01-09

398

Flight Formation of Multiple UAVs  

Microsoft Academic Search

\\u000a To conclude the whole monograph, we feature respectively in Chaps. 10 and 11 the applications of the unmanned rotorcraft systems constructed. More specifically, in Chap. 10, we present some basic results\\u000a on flight formation and collision avoidance of multiple unmanned systems. We adopt the leader-follower pattern to maintain\\u000a a fixed geometrical formation while navigating the unmanned rotorcraft following certain trajectories. In order

Guowei Cai; Ben M. Chen; Tong Heng Lee

399

Asymptotic Results for Multiple Imputation  

Microsoft Academic Search

Imputation and multiple-imputation procedures have been used in practice to handle the problem of ignorable nonresponse in sample surveys. We examine the large-sample properties of these procedures where covariates are available for the case when the complete-data analysis is based on least squares. The results provide a formal justification for the inference procedures discussed by Rubin and Schenker for the

Nathaniel Schenker; A. H. Welsh

1988-01-01

400

Multiple Imputation after 18+ Years  

Microsoft Academic Search

Multiple imputation was designed to handle the problem of missing data in public-use data bases where the data-base constructor and the ultimate user are distinct entities. The objective is valid frequency inference for ultimate users who in general have access only to complete-data software and possess limited knowledge of specific reasons and models for nonresponse. For this situation and objective,

Donald B. Rubin

1996-01-01

401

Channel-Hopping Multiple Access  

Microsoft Academic Search

The medium-access control (MAC) protocols for wireless networks proposed or implemented to date based on collision-avoidance handshakes between sender and receiver either require carrier sensing or the assignment of unique codes to nodes to ensure that intended receivers hear data packets without interference from hidden sources. We present and analyze a protocol that we call channel-hopping multiple access (CHMA) for

Asimakis Tzamaloukas; J. J. Garcia-luna-aceves

2000-01-01

402

Protocol for multiple node network  

NASA Technical Reports Server (NTRS)

The invention is a multiple interconnected network of intelligent message-repeating remote nodes which employs an antibody recognition message termination process performed by all remote nodes and a remote node polling process performed by other nodes which are master units controlling remote nodes in respective zones of the network assigned to respective master nodes. Each remote node repeats only those messages originated in the local zone, to provide isolation among the master nodes.

Kirkham, Harold (Inventor)

1995-01-01

403

Protocol for multiple node network  

NASA Technical Reports Server (NTRS)

The invention is a multiple interconnected network of intelligent message-repeating remote nodes which employs an antibody recognition message termination process performed by all remote nodes and a remote node polling process performed by other nodes which are master units controlling remote nodes in respective zones of the network assigned to respective master nodes. Each remote node repeats only those messages originated in the local zone, to provide isolation among the master nodes.

Kirkham, Harold (Inventor)

1994-01-01

404

Multiple target laser ablation system  

DOEpatents

A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

Mashburn, Douglas N. (Knoxville, TN)

1996-01-01

405

The paradox of multiple elections  

Microsoft Academic Search

.   Assume that voters must choose between voting yes (Y) and voting no (N) on three propositions on a referendum. If the winning\\u000a combination is NYY on the first, second, and third propositions, respectively, the paradox of multiple elections is that NYY can receive the fewest votes of the 23?=?8 combinations. Several variants of this paradox are illustrated, and necessary

Steven J. Brams; D. Marc Kilgour; William S. Zwicker

1998-01-01

406

Multiple-Segment Climbing Robots  

NASA Technical Reports Server (NTRS)

Multiple-segment climbing robots developed to perform such tasks as inspection, sandblasting, welding, and painting on towers and other structures. Look and move like caterpillars. Video camera mounted on one of segments rotated to desired viewing angle. Used in remote inspection of structure, to view motion of robot and/or provides video feedback for control of motion, and/or to guide operation of head mounted on foremost segment with motorized actuators.

Kerley, James; May, Edward; Eklund, Wayne

1994-01-01

407

Bone diesease in multiple myeloma  

Microsoft Academic Search

A new understanding of the regulation of bone resorption developed with the discovery of receptor activator of nuclear factor-kappaB,\\u000a receptor activator of nuclear factor-kappaB ligand, and osteoprotegerin in 1997–1998. The RANK signaling system is abnormally\\u000a regulatedin multiple myeloma, and this favors increased osteoclast function, which early in the disease is compensated by\\u000a increased osteoblast function. Later in the disease osteoblast

Øyvind Hjertner; Therese Standal; Magne Børset; Anders Sundan; Anders Waage

2006-01-01

408

Decimal Floating-Point Multiplication  

Microsoft Academic Search

Decimal multiplication is important in many com- mercial applications including financial analysis, banking, tax calculation, currency conversion, insurance, and accounting. This paper presents the design of two decimal floating-point multipli- ers; one whose partial product accumulation strategy employs decimal carry-save addition, and one which employs binary carry-save addition. The multiplier based on decimal carry- save addition favors a non-pipelined, iterative

Mark A. Erle; Brian J. Hickmann; Michael J. Schulte

2009-01-01

409

Multiple man-machine interfaces  

NASA Technical Reports Server (NTRS)

The multiple man machine interfaces inherent in military pilot training, their social implications, and the issue of possible negative feedback were explored. Modern technology has produced machines which can see, hear, and touch with greater accuracy and precision than human beings. Consequently, the military pilot is more a systems manager, often doing battle against a target he never sees. It is concluded that unquantifiable human activity requires motivation that is not intrinsic in a machine.

Stanton, L.; Cook, C. W.

1981-01-01

410

Multiplicities in high energy interactions  

SciTech Connect

Charged particle multiplicities in hadronic collision have been measured for all energies up to ..sqrt..s = 540 GeV in the center of mass. Similar measurements in e/sup +/e/sup -/ annihilation cover the much smaller range - up to ..sqrt..s = 40 GeV. Data are also available from deep inelastic neutrino scattering up to ..sqrt..s approx. 10 GeV. The experiments measure the mean charged multiplicity , the rapidity density at y = O, and the distributions in prong number. The mean number of photons associated with the events can be used to measure the ..pi../sup 0/ and eta/sup 0/ multiplicities. Some information is also available on the charged pion, kaon, and nucleon fractions as well as the K/sup 0/ and ..lambda../sup 0/ rates and for the higher energy data, the identically equal fraction. We review this data and consider the implications of extrapolations to SSC energies. 13 references.

Derrick, M.

1984-01-01

411

Immune Tolerance in Multiple Sclerosis  

PubMed Central

Summary Multiple sclerosis is believed to be mediated by T cells specific for myelin antigens that circulate harmlessly in the periphery of healthy individuals until they are erroneously by an environmental stimulus. Upon activation, the T cells enter the central nervous system and orchestrate an immune response against myelin. To understand the initial steps in the pathogenesis of multiple sclerosis, it is important to identify the mechanisms that maintain T-cell tolerance to myelin antigens and to understand how some myelin-specific T cells escape tolerance and what conditions lead to their activation. Central tolerance strongly shapes the peripheral repertoire of myelin-specific T cells, as most myelin-specific T cells are eliminated by clonal deletion in the thymus. Self-reactive T cells that escape central tolerance are generally capable only of low-avidity interactions with antigen-presenting cells. Despite the low avidity of these interactions, peripheral tolerance mechanisms are required to prevent spontaneous autoimmunity. Multiple peripheral tolerance mechanisms for myelin-specific T cells have been indentified, the most important of which appears to be regulatory T cells. While most studies have focused on CD4+ myelin-specific T cells, interesting differences in tolerance mechanisms and the conditions that abrogate these mechanisms have recently been described for CD8+ myelin-specific T cells.

Goverman, Joan M.

2011-01-01

412

Multiplicative MJO forcing of ENSO  

NASA Astrophysics Data System (ADS)

The role of sea surface temperature (SST) feedback to the Madden-Julian Oscillation (MJO) in its influences on El Niño—Southern Oscillation (ENSO) is studied using a coupled ocean-atmosphere model of intermediate complexity. Zonal surface wind of the MJO is expressed in terms of few basic parameters, such as amplitude, zonal extent, interval between two adjacent MJO events, and zonal propagating speed. Each MJO parameter includes a most probable value, a degree of stochasticity, and SST feedback. Simulations of two 100-member ensembles were generated: one without SST feedback (additive) and one with SST-feedback (multiplicative). ENSO statistics are compared between the two ensembles, and between the ensembles and observations. Nearly all ENSO properties are found to be sensitive to the most-probable value, stochasticity, and SST feedback of some MJO parameters. When MJO's zonal propagation speed is reduced to zero, ENSO signal vanishes. ENSO variance increases with both stochasticity and SST feedback to MJO amplitude, non-linearly dependent on SST feedback to zonal-extent of MJO, but is insensitive to stochasticity in other MJO parameters. Ensemble comparisons between additive and multiplicative MJO forcing reveal that at least in the stable regime, SST feedback to the MJO can be responsible for the observed variance of ENSO SSTs. ENSO under the multiplicative MJO forcing has larger ensemble spread, suggesting a larger interdecadal variability, than under the additive forcing.

Zhang, Chidong; Kapur, Atul

2013-04-01

413

Optical multiple object tracking techniques  

NASA Technical Reports Server (NTRS)

Two multichannel multiple-object tracking techniques are reviewed. In the diffraction grating technique, the input scene is picked up by a TV camera and imaged onto a liquid-crystal light valve (LCLV), and the output side of the light valve is illuminated with a suitably polarized and collimated coherent laser beam to yield a reflected beam with polarization modulated according to the intensity of the incoherent input. This reflected beam passes through a beam splitter cube and an analyzer, resulting in an intensity modulated coherent image. An array of spectrum islands containing the information of the input appears after crossing a contact screen/lens combination. In the multiple-focus hololens technique, the scene of moving objects is sent into the LCTVSLM through a camera; a collimated laser beam is incident upon the LCTV screen; a low-pass filter is inserted between the LCTVSLM and the hololens for the removal of the high order diffractions due to the grid structure of the LCTV. The feasibility of the LCTVSLM and multiple-focus hololens technique is demonstrated.

Liu, Hua-Kuang; Chao, Tien-Hsin

1989-01-01

414

Multiple collisions in turbulent flows.  

PubMed

In turbulent suspensions, collision rates determine how rapidly particles coalesce or react with each other. To determine the collision rate, many numerical studies rely on the ghost collision approximation (GCA), which simply records how often pairs of point particles come within a threshold distance. In many applications, the suspended particles stick (or in the case of liquid droplets, coalesce) upon collision, and it is the frequency of first contact which is of interest. If a pair of "ghost" particles undergoes multiple collisions, the GCA may overestimate the true collision rate. Here, using fully resolved direct numerical simulations of turbulent flows at moderate Reynolds number (Re(?)=130), we investigate the prevalence and properties of multiple collisions. We find the probability P(N(c)) for a given pair of ghost particles to collide N(c) times to be of the form P(N(c))=??(N(c)) for N(c)>1, where ? and ? are coefficients which depend upon the particle inertia. We also investigate the statistics of the times that ghost particles remain in contact. We show that the probability density function of the contact time is different for the first collision. The difference is explained by the effect of caustics in the phase space of the suspended particles. We demonstrate that, as a result of multiple collisions, the GCA leads to a small, but systematic overestimate of the collision rate, which is of the order of ?15% when the particle inertia is small, and slowly decreases when inertia increases. PMID:24483558

Vosskuhle, Michel; Lévêque, Emmanuel; Wilkinson, Michael; Pumir, Alain

2013-12-01

415

Trapezium Multiple Systems (Salukvadze, 1978)  

NASA Astrophysics Data System (ADS)

The present catalogue of Trapezium-type Multiple Systems was compiled on the basis of the Index Catalogue of Visual Binary Stars (IDS, Jeffers et al., 1963). At the period of compilation of the Abastumani catalogue, IDS was the most complete catalogue concerning not only stars, but also the data on double stars. Besides giving relative positions, IDS presents the coordinates at 1900 and 2000 epochs, as well as in most cases magnitudes, spectral classes and proper motions. IDS contains all double and multiple stars from the North to the South poles with relative positions published up to the end of 1960, their total number being 64247. In order to select optimum value of K (ratio of the largest to the smallest distances among the components), which is the main criterion for relating a multiple star to the trapezium type, the dependence of the observed trapezia number on the K value has been analysed, and the value 2.6 adopted for it. To exclude optical components, upper limits for the distances of faint components to the main star have been introduced, and the components fainter than 12.5mag were excluded altogether (Salukvadze, 1978). The catalogue of Trapezium-type Multiple Systems contains 412 trapezia, for which, after examining all main spectral catalogues (Jaschek et al., 1964; Kennedy et al., 1974; Houck et al., 1975; Cruz-Gonzales et al., 1974; Lindsey et al., 1968), spectral classes in the MK system have been specified. This was done for 100 systems, including 65 stars of O and B spectral classes. The following data on trapezia are given in the catalogue: positional angles and distances, magnitudes and spectral classes according to HD as well as MK, the ADS and BD identification number of the main star. On the basis of the probability, deduced by Ambartsumian (1954), the number of pseudo-trapezia was estimated, that is, the number of multiple stars, which in fact have no trapezium-type configurations, but are observed as trapezia as a result of their projection on the celestial sphere. The number of estimated pseudo-trapezia is 167. It should be mentioned that among 59 trapezia, the main components of which are of the O-B2 spectral class, there are only 5 pseudo-trapezia. This enables us to maintain that there is a considerable percent of real trapezia among the ones of mentioned spectral classes. Evaluation of the number of optical systems, formed as a result of the appearance of background stars in circles, which are determined by the upper limits of components' distances, led to their insignificant number 9. (1 data file).

Salukvadze, G. N.

1997-02-01

416

Multiple Sebaceous Neoplasms of the Skin: An Association with Multiple Visceral Carcinomas, Especially of the Colon.  

National Technical Information Service (NTIS)

Five patients with multiple sebaceous neoplasms of the skin in association with multiple visceral cancers are reported. The visceral cancers involved particularly the gastrointestinal tract, and multiple adenocarcinomas of the colon were common. This repo...

D. B. Rulon E. B. Helwig

1973-01-01

417

Inflammatory Cortical Demyelination in Early Multiple Sclerosis  

PubMed Central

BACKGROUND Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment. Most studies of cortical lesions have focused on autopsy findings in patients with long-standing, chronic, progressive multiple sclerosis, and the noninflammatory nature of these lesions has been emphasized. Magnetic resonance imaging studies indicate that cortical damage occurs early in the disease. METHODS We evaluated the prevalence and character of demyelinating cortical lesions in patients with multiple sclerosis. Cortical tissues were obtained in passing during biopsy sampling of white-matter lesions. In most cases, biopsy was done with the use of stereotactic procedures to diagnose suspected tumors. Patients with sufficient cortex (138 of 563 patients screened) were evaluated for cortical demyelination. Using immunohistochemistry, we characterized cortical lesions with respect to demyelinating activity, inflammatory infiltrates, the presence of meningeal inflammation, and a topographic association between cortical demyelination and meningeal inflammation. Diagnoses were ascertained in a subgroup of 77 patients (56%) at the last follow-up visit (at a median of 3.5 years). RESULTS Cortical demyelination was present in 53 patients (38%) (104 lesions and 222 tissue blocks) and was absent in 85 patients (121 tissue blocks). Twenty-five patients with cortical demyelination had definite multiple sclerosis (81% of 31 patients who underwent long-term follow-up), as did 33 patients without cortical demyelination (72% of 46 patients who underwent long-term follow-up). In representative tissues, 58 of 71 lesions (82%) showed CD3+ T-cell infiltrates, and 32 of 78 lesions (41%) showed macrophage-associated demyelination. Meningeal inflammation was topographically associated with cortical demyelination in patients who had sufficient meningeal tissue for study. CONCLUSIONS In this cohort of patients with early-stage multiple sclerosis, cortical demyelinating lesions were frequent, inflammatory, and strongly associated with meningeal inflammation. (Funded by the National Multiple Sclerosis Society and the National Institutes of Health.)

Lucchinetti, Claudia F.; Popescu, Bogdan F.G.; Bunyan, Reem F.; Moll, Natalia M.; Roemer, Shanu F.; Lassmann, Hans; Bruck, Wolfgang; Parisi, Joseph E.; Scheithauer, Bernd W.; Giannini, Caterina; Weigand, Stephen D.; Mandrekar, Jay; Ransohoff, Richard M.

2012-01-01

418

Unraveling Multiple MHC Gene Associations with Systemic Lupus Erythematosus: Model Choice Indicates a Role for HLA Alleles and Non-HLA Genes in Europeans  

PubMed Central

We have performed a meta-analysis of the major-histocompatibility-complex (MHC) region in systemic lupus erythematosus (SLE) to determine the association with both SNPs and classical human-leukocyte-antigen (HLA) alleles. More specifically, we combined results from six studies and well-known out-of-study control data sets, providing us with 3,701 independent SLE cases and 12,110 independent controls of European ancestry. This study used genotypes for 7,199 SNPs within the MHC region and for classical HLA alleles (typed and imputed). Our results from conditional analysis and model choice with the use of the Bayesian information criterion show that the best model for SLE association includes both classical loci (HLA-DRB1?03:01, HLA-DRB1?08:01, and HLA-DQA1?01:02) and two SNPs, rs8192591 (in class III and upstream of NOTCH4) and rs2246618 (MICB in class I). Our approach was to perform a stepwise search from multiple baseline models deduced from a priori evidence on HLA-DRB1 lupus-associated alleles, a stepwise regression on SNPs alone, and a stepwise regression on HLA alleles. With this approach, we were able to identify a model that was an overwhelmingly better fit to the data than one identified by simple stepwise regression either on SNPs alone (Bayes factor [BF] > 50) or on classical HLA alleles alone (BF > 1,000).

Morris, David L.; Taylor, Kimberly E.; Fernando, Michelle M.A.; Nititham, Joanne; Alarcon-Riquelme, Marta E.; Barcellos, Lisa F.; Behrens, Timothy W.; Cotsapas, Chris; Gaffney, Patrick M.; Graham, Robert R.; Pons-Estel, Bernardo A.; Gregersen, Peter K.; Harley, John B.; Hauser, Stephen L.; Hom, Geoffrey; Langefeld, Carl D.; Noble, Janelle A.; Rioux, John D.; Seldin, Michael F.; Criswell, Lindsey A.; Vyse, Timothy J.

2012-01-01

419

Tracking multiple occluding people by localizing on multiple scene planes.  

PubMed

Occlusion and lack of visibility in crowded and cluttered scenes make it difficult to track individual people correctly and consistently, particularly in a single view. We present a multi-view approach to solving this problem. In our approach we neither detect nor track objects from any single camera or camera pair; rather evidence is gathered from all the cameras into a synergistic framework and detection and tracking results are propagated back to each view. Unlike other multi-view approaches that require fully calibrated views our approach is purely image-based and uses only 2D constructs. To this end we develop a planar homographic occupancy constraint that fuses foreground likelihood information from multiple views, to resolve occlusions and localize people on a reference scene plane. For greater robustness this process is extended to multiple planes parallel to the reference plane in the framework of plane to plane homologies. Our fusion methodology also models scene clutter using the Schmieder and Weathersby clutter measure, which acts as a confidence prior, to assign higher fusion weight to views with lesser clutter. Detection and tracking are performed simultaneously by graph cuts segmentation of tracks in the space-time occupancy likelihood data. Experimental results with detailed qualitative and quantitative analysis, are demonstrated in challenging multi-view, crowded scenes. PMID:19147878

Khan, Saad M; Shah, Mubarak

2009-03-01

420

Complications and Problems Associated with Multiple Births  

MedlinePLUS

... are at higher risk to get pregnant with twins, and rarely with triplets or more. This is called multiple gestation. Multiple gestation can increase the risk of pregnancy for the mother and for all the babies. ...

421

Optimization of Multiple-Response Simulation Models.  

National Technical Information Service (NTIS)

This report describes several computerized multiple-variable, multiple-response optimization procedures for use in connection with computer simulation models. These procedures include complex search, a sequential first-order response surface approach, a s...

W. E. Biles

1978-01-01

422

Multiple-Fold Clustered Processor Mesh Array.  

National Technical Information Service (NTIS)

The multiple-fold clustered processor mesh array is a triangular organization of clustered processing elements. This multiple-fold array maintains functional equivalence to the nearest neighbor mesh computer with uni-directional interprocessor communicati...

G. G. Pechanek S. Vassiliadis J. G. Delgado

1993-01-01

423

42 CFR 102.45 - Multiple survivors.  

Code of Federal Regulations, 2013 CFR

...PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request...Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...

2013-10-01

424

All About Multiplication Exploring Equal Sets  

NSDL National Science Digital Library

Students explore the set model for multiplication. They find products using equal sets and present their results in a table. Next students apply their knowledge about multiplication in the creation of pictographs (from NCTM's Illuminations website).

Math, Illuminations N.

2009-03-17

425

The Multiple Control of Verbal Behavior  

PubMed Central

Amid the novel terms and original analyses in Skinner's Verbal Behavior, the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms convergent multiple control and divergent multiple control. We point out some implications for applied work and discuss examples of the role of multiple control in humor, poetry, problem solving, and recall. Joint control and conditional discrimination are discussed as special cases of multiple control. We suggest that multiple control is a useful analytic tool for interpreting virtually all complex behavior, and we consider the concepts of derived relations and naming as cases in point.

Michael, Jack; Palmer, David C; Sundberg, Mark L

2011-01-01

426

The multiple control of verbal behavior.  

PubMed

Amid the novel terms and original analyses in Skinner's Verbal Behavior, the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms convergent multiple control and divergent multiple control. We point out some implications for applied work and discuss examples of the role of multiple control in humor, poetry, problem solving, and recall. Joint control and conditional discrimination are discussed as special cases of multiple control. We suggest that multiple control is a useful analytic tool for interpreting virtually all complex behavior, and we consider the concepts of derived relations and naming as cases in point. PMID:22532752

Michael, Jack; Palmer, David C; Sundberg, Mark L

2011-01-01

427

Multiple Instance Regression with Structured Data  

NASA Technical Reports Server (NTRS)

This slide presentation reviews the use of multiple instance regression with structured data from multiple and related data sets. It applies the concept to a practical problem, that of estimating crop yield using remote sensed country wide weekly observations.

Wagstaff, Kiri L.; Lane, Terran; Roper, Alex

2008-01-01

428

46 CFR 183.322 - Multiple generators.  

Code of Federal Regulations, 2013 CFR

... 2013-10-01 false Multiple generators. 183.322 Section 183.322 ...Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2013-10-01

429

46 CFR 120.322 - Multiple generators.  

Code of Federal Regulations, 2013 CFR

... 2013-10-01 false Multiple generators. 120.322 Section 120.322 ...Distribution Systems § 120.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2013-10-01

430

Complementary and Alternative Medicine for Multiple Sclerosis  

MedlinePLUS

... for PATIENTS and their FAMILIES COMPLEMENTARY AND ALTERNATIVE MEDICINE FOR MULTIPLE SCLEROSIS This fact sheet is provided ... understand the current evidence regarding complementary and alternative medicine (CAM) for treatment of multiple sclerosis (MS). The ...

431

Smart card multiple function badge  

SciTech Connect

Smart cards are credit card-sized computers with integrated data storage, an operating system to manage the data, and built-in security features that protect the data. They are used to distribute information to remote sites, providing the same or greater reliability, data integrity, and information security than a network system. However, smart cards may provide greater functionality at a lower cost than network systems. The US Department of Energy Hanford Site is developing the smart card to be used as a multiple function identification badge that will service various data management requirements on the Site. This paper discusses smart card technology and the proposed Hanford Site applications.

Nelson, R.A.

1993-06-01

432

Multiple piece turbine rotor blade  

DOEpatents

A multiple piece turbine rotor blade with a shell having an airfoil shape and secured between a spar and a platform with the spar including a tip end piece. a snap ring fits around the spar and abuts against the spar tip end piece on a top side and abuts against a shell on the bottom side so that the centrifugal loads from the shell is passed through the snap ring and into the spar and not through a tip cap dovetail slot and projection structure.

Jones, Russell B; Fedock, John A

2013-05-21

433

Stochastic assessment of multiple illuminations  

NASA Astrophysics Data System (ADS)

Stochastic assessment of multiple illuminations (SAMI) is a quantifiably robust hand calculator model which uses applied probability theory to yield the mean and standard deviation of beam-on-beam illumination events for a target located in an active threat sensor environment. The electromagnetic wave front arrival model predicts simultaneous illuminations of a target by using the mechanical properties of a radar type as inputs into a mathematically defensible and situation sensitive formula. The SAMI methodology can be recursively applied to yield the same results for pulse-on-pulse occurrences within the beam-on-beam events.

Love, Newton, Jr.

434

Universality of Charged Multiplicity Distributions  

SciTech Connect

The charged multiplicity distributions of the diffractive and non-diffractive components of hadronic interactions, as well as those of hadronic states produced in other reactions, are described well by a universal Gaussian function that depends only on the available mass for pionization, has a maximum at n{sub o} {approx_equal} 2M{sup 1/2}, where M is the available mass in GeV, and a peak to width ratio n{sub o}/D {approx_equal} 2.

Goulianos, K.; /Rockefeller U.

1981-12-01

435

Multiple imputation in quantile regression  

PubMed Central

Summary We propose a multiple imputation estimator for parameter estimation in a quantile regression model when some covariates are missing at random. The estimation procedure fully utilizes the entire dataset to achieve increased efficiency, and the resulting coefficient estimators are root-n consistent and asymptotically normal. To protect against possible model misspecification, we further propose a shrinkage estimator, which automatically adjusts for possible bias. The finite sample performance of our estimator is investigated in a simulation study. Finally, we apply our methodology to part of the Eating at American’s Table Study data, investigating the association between two measures of dietary intake.

Wei, Ying; Ma, Yanyuan; Carroll, Raymond J.

2014-01-01

436

Ermakov systems with multiplicative noise  

NASA Astrophysics Data System (ADS)

Using the Euler-Maruyama numerical method, we present calculations of the Ermakov-Lewis invariant and the dynamic, geometric, and total phases for several cases of stochastic parametric oscillators, including the simplest case of the stochastic harmonic oscillator. The results are compared with the corresponding numerical noiseless cases to evaluate the effect of the noise. Besides, the noiseless cases are analytic and their analytic solutions are briefly presented. The Ermakov-Lewis invariant is not affected by the multiplicative noise in the three particular examples presented in this work, whereas there is a shift effect in the case of the phases.

Cervantes-López, E.; Espinoza, P. B.; Gallegos, A.; Rosu, H. C.

2014-05-01

437

[Multiple agenesis and prosthetic restoration].  

PubMed

Cases of multiple agenesia present some difficulties in the treatment planing. Three situations may be encountered: limited agenesia, restored by a fixed, bonded or cemented prosthesis, multiple uni- or bimaxillary agenesia without remaining of deciduous teeth, restored by a fixed, bonded or cemented prosthesis or the partial adjacent prosthesis, multiple uni- or bimaxillary agenesia with remaining of deciduous teeth, restored by means of a supra-dental prosthesis. The first two situations have been described in dental literature and are relatively easy to treat. The same is not true for the third situation, where the decision to keep the temporary teeth considerably increases the difficulty of prosthetic restoration. This subject will be illustrated by the presentation of a clinical case of multiple bi-maxillary agenesia. The patient has: on the maxilla: an absence of 9 permanent teeth (18, 15, 14, 12, 22, 23, 24, 25, 28) and the presence of 4 deciduous teeth (62, 63, 64, 65), on the mandible: an absence of all permanent teeth, with the exception of 36 and 46, and the remaining of 4 deciduous teeth (75, 73, 83, 84). The remaining of deciduous teeth and the presence of a very high inter-arch space led to opting for dental coverage so as to keep the deciduous teeth and a proper vertical dimension. The patient wished to solve his "problem" in the maxilla first, and is not wanting to undergo the extraction of his deciduous teeth. The following therapeutic proposal was adapted: On the maxilla, a three-step procedure: first step: building of metal copings on 13, 16 and 26 and metal-ceramic crowns on 11 and 21, second step: building of telescop crowns on 16 and 26 and clasps on 13, 11 and 21, third step: casting of the removable partial denture framework and soldering to the telescop crowns and clasps. On the mandible, a provisional restoration using a supra-dental resin removable partial denture with ceramic occlusal surfaces was adopted. The aesthetic and functional improvement, as well as the comfort provided to the patient due to this kind of mixed prosthesis, appeared to be satisfactory. PMID:2200566

Renault, P

1990-03-01

438

[Driving ability with multiple sclerosis].  

PubMed

Driving is an important issue for young patients, especially for those whose walking capacity is impaired. Driving might support the patient's social and vocational participation. The question as to whether a patient with multiple sclerosis (MS) is restricted in the ability to drive a car depends on neurological and neuropsychological deficits, self-awareness, insight into deficits and ability to compensate for loss of function. Because of the enormous variability of symptoms in MS the question is highly individualized. A practical driving test under supervision of a driving instructor (possibly accompanied by a neuropsychologist) might be helpful in providing both patient and relatives adequate feedback on driving abilities. PMID:24906536

Küst, J; Dettmers, C

2014-07-01

439

4.OA Multiples of nine  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: Stating with 9, list the first 10 multiples of 9. In the list in part (a) what patterns do you see with the digits in the 10's place? What patterns do ...

440

Multiple channel programmable coincidence counter  

SciTech Connect

A programmable digital coincidence counter having multiple channels and featuring minimal dead time. Neutron detectors supply electrical pulses to a synchronizing circuit which in turn inputs derandomized pulses to an adding circuit. A random access memory circuit connected as a programmable length shift register receives and shifts the sum of the pulses, and outputs to a serializer. A counter is input by the adding circuit and downcounted by the seralizer, one pulse at a time. The decoded contents of the counter after each decrement is output to scalers.

Arnone, Gaetano J. (Los Alamos, NM)

1990-01-01

441

Multiple channel programmable coincidence counter  

SciTech Connect

A programmable digital coincidence counter having multiple channels and featuring minimal dead time. Neutron detectors supply electrical pulses to a synchronizing circuit which in turn inputs derandomized pulses to an adding circuit. A random access memory circuit connected as a programmable length shift register receives and shifts the sum of the pulses, and outputs to a serializer. A counter is input by the adding circuit and downcounted by the serializer, one pulse at a time. The decoded contents of the counter after each decrement is output to scalers.

Arnone, G.J.

1989-02-27

442

Multiple channel programmable coincidence counter  

SciTech Connect

This patent describes a programmable digital coincidence counter having multiple channels and featuring minimal dead time. Neutron detectors supply electrical pulses to a synchronizing circuit which in turn inputs derandomized pulses to an adding circuit. A random access memory circuit connected as a programmable length shift register receives and shifts the sum of the pulses, and outputs to a serializer. A counter is input by the adding circuit and downcounted by the seralizer, one pulse at a time. The decoded contents of the counter after each decrement is output to scalers.

Arnone, G.J.

1990-04-24

443

Recirculation in multiple wave conversions  

SciTech Connect

A one-dimensional multiple wave-conversion model is constructed that allows energy recirculation in ray phase space. Using a modular eikonal approach, the connection coefficients for this model are calculated by ray phase-space methods. Analytical results (confirmed numerically) show that all connection coefficients exhibit interference effects that depend on an interference phase, calculated from the coupling constants and the area enclosed by the intersecting rays. This conceptual model, which focuses on the topology of intersecting rays in phase space, is used to investigate how mode conversion between primary and secondary waves is modified by the presence of a tertiary wave.

Kaufman, A. N.; Brizard, A.J.; Kaufman, A.N.; Tracy, E.R.

2008-07-30

444

Coordination of multiple robot arms  

NASA Technical Reports Server (NTRS)

Kinematic resolved-rate control from one robot arm is extended to the coordinated control of multiple robot arms in the movement of an object. The structure supports the general movement of one axis system (moving reference frame) with respect to another axis system (control reference frame) by one or more robot arms. The grippers of the robot arms do not have to be parallel or at any pre-disposed positions on the object. For multiarm control, the operator chooses the same moving and control reference frames for each of the robot arms. Consequently, each arm then moves as though it were carrying out the commanded motions by itself.

Barker, L. K.; Soloway, D.

1987-01-01

445

Multiple hypothesis testing in genomics.  

PubMed

This paper presents an overview of the current state of the art in multiple testing in genomics data from a user's perspective. We describe methods for familywise error control, false discovery rate control and false discovery proportion estimation and confidence, both conceptually and practically, and explain when to use which type of error rate. We elaborate on the assumptions underlying the methods and discuss pitfalls in the interpretation of results. In our discussion, we take into account the exploratory nature of genomics experiments, looking at selection of genes before or after testing, and at the role of validation experiments. Copyright © 2014 John Wiley & Sons, Ltd. PMID:24399688

Goeman, Jelle J; Solari, Aldo

2014-05-20

446

Superficial radiotherapy for multiple keratoacanthomas.  

PubMed

We report the case of a 76-year-old Caucasian woman who attended our clinic with multiple keratoacanthomas. Radiotherapy was considered a viable and effective option in such an old patient, who could not be a good surgical candidate for number and distribution of the lesions, and for the age. After a 12-month follow-up, we observed the complete and global disappearance of the lesions; the patient was therefore very satisfied especially in view of the clinical outcome. According to our point of view, radiotherapy allows the physician to obtain a good oncological radicality and excellent cosmetic results too. PMID:25032245

Bruscino, N; Corradini, D; Campolmi, P; Massi, D; Palleschi, G M

2014-01-01

447

Epidemiology in multiple sclerosis: a pilgrim's progress.  

PubMed

There was more neurology taught under Harold G. Wolff at Cornell University Medical College in New York than perhaps anywhere else in the country when I attended from 1948 to 1952. I took my residency at the Veterans Administration Hospital in the Bronx, New York, a teaching hospital of Cornell, with Wolff as my Director of Training. While a resident, we thought we had found a treatment for multiple sclerosis. To test our conclusion, the first Class 1 treatment trial ever conducted for multiple sclerosis was performed. This showed no effect, but the participants began investigating multiple sclerosis among the 16 million persons at prime age for symptom onset who had served in the military in World War II. This led me to study its epidemiology worldwide, beginning with a detailed review of all published population-based estimates of frequency. Among these were nationwide surveys from Sweden, Denmark, Switzerland and later Norway and Finland, which showed in each country a concentration of the significantly high regions into contiguous areas forming a single 'focus' in each land, maximal in Denmark under the age of 15 years. The primary locus of high frequency multiple sclerosis seemed to be in the south-central inland lake region of Sweden, with spread to its contiguous neighbours. These concentrations in time and space indicated that multiple sclerosis was a disease probably acquired in early adolescence. Migration studies supported this: moves from high to low showed retention of birthplace risk only for those aged >15 years, whereas opposite moves indicated susceptibility limited to some 11-45 year olds. Epidemics of multiple sclerosis would suggest the disease is not only acquired but also infectious. If an infectious origin were true, transmission would have to occur before clinical onset, and would have to involve a much greater number of subjects than clinically involved. I believe there have been epidemics in Iceland, Shetland-Orkney and the Faroe Islands. On the Faroes there were no cases of multiple sclerosis among native-born resident Faroese from 1900 until 1943, when the first of 21 cases had clinical onset, heralding a type 1 epidemic with peak incidence rates >10 per 100,000 for 1945-46. British troops who occupied the islands from April 1940 to September 1945 we believe brought a widespread (because of the scatter of Faroese cases), asymptomatic (because they were healthy troops), persistent infection we called the primary multiple sclerosis affection that involved a large proportion of Faroese, with clinical multiple sclerosis ensuing in a very small proportion. Primary multiple sclerosis affection itself may have been manifest there as a newly introduced cause of acute infectious gastroenteritis and is possibly the underlying cause of multiple sclerosis in general. PMID:23983034

Kurtzke, John F

2013-09-01

448

Identifying the Multiple Intelligences of Your Students  

ERIC Educational Resources Information Center

One way of addressing individual differences among adult learners is to identify the Multiple Intelligences of the learner. Multiple Intelligences refers to the concept developed by Howard Gardner that challenges the traditional view of intelligence and explains the presence of nine different Multiple Intelligences. The purpose of this study was…

McClellan, Joyce A.; Conti, Gary J.

2008-01-01

449

Deconstructing Calculation Methods, Part 3: Multiplication  

ERIC Educational Resources Information Center

In this third of a series of four articles, the author deconstructs the primary national strategy's approach to written multiplication. The approach to multiplication, as set out on pages 12 to 15 of the primary national strategy's "Guidance paper" "Calculation" (DfES, 2007), is divided into six stages: (1) mental multiplication using…

Thompson, Ian

2008-01-01

450

Disintegrating Multiple Systems in Early Stellar Evolution  

Microsoft Academic Search

An analysis of the multiplicity of 14 sources driving giant Herbig-Haro flows has revealed an observed binary frequency between 79% and 86%, of which half are higher order multiples. These sources represent the hitherto youngest sample of stars examined for binarity. I postulate that the dynamical decay of triple or multiple systems leads to strong outflow activity. It is well

Bo Reipurth

2000-01-01

451

Hypnosis creates multiple personality: Myth or reality?  

Microsoft Academic Search

Since before the turn of the century, multiple personality has been associated with hysteria and hypnosis. The myth that hypnosis can create multiple personality is examined in this paper by reviewing studies that have suggested or implied a casual link between hypnosis and multiple personality. While it is possible that personality fragments can appear under hypnosis, there is no evidence

Bennett G. Braun

1984-01-01

452

Multiple Interval Mapping for Quantitative Trait Loci  

Microsoft Academic Search

A new statistical method for mapping quantitative trait loci (QTL), called multiple interval mapping (MIM), is presented. It uses multiple marker intervals simultaneously to fit multiple putative QTL directly in the model for mapping QTL. The MIM model is based on Cockerham's model for interpreting genetic parameters and the method of maximum likelihood for estimating genetic parameters. With the MIM

Chen-Hung Kao; Zhao-Bang Zeng; Robert D. Teasdale

453

Multiple agminated trichodiscomas in the earlobe  

Microsoft Academic Search

Trichodiscomas are hamartomas of the hair disk and appear as multiple, firm, well-circumscribed papules measuring a few millimeters. In most cases, trichodiscomas are distributed on the face and neck. Trichodiscomas may occur as isolated tumors or in association with other follicular tumors. In some cases, multiple trichodiscomas appear in association with fibrofolliculomas or acrochordons. We herein describe multiple agminated trichodiscomas

Arnon D Cohen; Marcelo H Grunwald; Ilana Avinoach; Sima Halevy

2003-01-01

454

Tools for analyzing multiple imputed datasets  

Microsoft Academic Search

The method of multiple imputation (MI) is used increasingly for analyzing datasets with missing observations. Two sets of tasks are required in order to implement the method: (a) generating multiple complete datasets in which missing values have been imputed by simulating from an appropriate probability distribution and (b) analyzing the multiple imputed datasets and combining complete data inferences from them

John B. Carlin; Ning Li; Philip Greenwood; Carolyn Coffey

2003-01-01

455

Fast multiple target tracking using particle filters  

Microsoft Academic Search

A fast algorithm for accurate initiation and tracking of multiple targets is developed. The basis of the approach is the linear multi-target (LM) method in which exact joint data association for multiple targets is approximated by single target data association for each target with clutter density modified to include contributions from neighbouring targets. This enables multiple target tracking to be

Mark R. Morelande; Darko Musicki

2005-01-01

456

The Method of Multiple Working Hypotheses  

NSDL National Science Digital Library

This essay describes the problems that can develop while working with multiple hypotheses and presents ideas for solving these problems. Topics discussed include premature theory development, the lingering of ruling theories, developing multiple working hypotheses, vacillation, and the potential drawbacks of working with multiple hypotheses.

Chamberlin, T. C.; Excellence, Access

457

The Multiple Control of Verbal Behavior  

ERIC Educational Resources Information Center

Amid the novel terms and original analyses in Skinner's "Verbal Behavior", the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms "convergent…

Michael, Jack; Palmer, David C.; Sundberg, Mark L.

2011-01-01

458

Targeted therapy of multiple myeloma.  

PubMed

Multiple myeloma (MM) is a plasma cell malignancy and the second most common hematologic cancer. MM is characterized by the accumulation of malignant plasma cells within the bone marrow, and presents clinically with a broad range of symptoms, including hypercalcemia, renal insufficiency, anemia, and lytic bone lesions. MM is a heterogeneous disease associated with genomic instability, where patients may express multiple genetic abnormalities that affect several oncogenic pathways. Commonly detected genetic aberrations are translocations involving immunoglobulin heavy chain (IgH) switch regions (chromosome 14q32) and oncogenes such as c-maf [t(14:16)], cyclin D1 [t(11:14)], and FGFR3/MMSET [t(4:14)]. Advances in the basic understanding of MM and the development of novel agents, such as the immunomodulatory drugs (IMiDs) thalidomide and lenalidomide and the proteasome inhibitor bortezomib, have increased therapeutic response rates and prolonged patient survival. Despite these advances MM remains incurable in the majority of patients, and it is therefore critical to identify additional therapeutic strategies and targets for its treatment. In this chapter, we review the underlying genetic components of MM and discuss the results of recent clinical trials that demonstrate the effectiveness of targeted agents in the management of MM. In addition, we discuss experimental therapies that are currently in clinical development along with their molecular rationale in the treatment of MM. PMID:23288641

Dolloff, Nathan G; Talamo, Giampaolo

2013-01-01

459

Outflows from Newborn Multiple Stars  

NASA Astrophysics Data System (ADS)

Analysis of a sample of giant Herbig-Haro flow sources shows that 79% - 86% are binaries or higher order multiples. This represents the youngest sample of stars studied so far for binarity. A stellar dynamics jet hypothesis is proposed in which the dynamical decay of triple or multiple systems leads to giant outflow activity. Close triple approaches will cause serious perturbations and probably direct collisions among individual circumstellar disks, with a consequent burst of outflow activity, which can produce giant HH bow shocks. As one component is ejected, the two remaining stars and their small truncated disks form a closer bound pair with high eccentricity. Gas streams from a circumbinary disk feed the stars and this as well as other dynamical effects cause the binary orbit to shrink. As the stellar components gradually spiral towards each other, accretion and outflow becomes cyclic, modulated on an orbital time scale. The resulting HH flows can be read as a fossil record of the evolution of orbital motions of the newly formed binary as it shrinks from a typical separation of 100 AU or more to 10 AU or less. After a triple disintegration event, both components (star and close binary) leave their nascent envelope, and while one component becomes visible as a T Tauri star, the other will be obscured for a while by the envelope and will appear as a bright near-infrared object, thus explaining the socalled IRC binaries which are infrequently found in star forming regions.

Reipurth, Bo

460

Multiple Waveband Temperature Sensor (MWTS)  

NASA Technical Reports Server (NTRS)

This slide presentation reviews the development of Multiple Waveband Temperature Sensor (MWTS). The MWTS project will result in a highly stable, monolithically integrated, high resolution infrared detector array sensor that records registered thermal imagery in four infrared wavebands to infer dynamic temperature profiles on a laser-irradiated ground target. An accurate surface temperature measurement of a target in extreme environments in a non-intrusive manner is required. The development challenge is to: determine optimum wavebands (suitable for target temperatures, nature of the targets and environments) to measure accurate target surface temperature independent of the emissivity, integrate simultaneously readable multiband Quantum Well Infrared Photodetectors (QWIPs) in a single monolithic focal plane array (FPA) sensor and to integrate the hardware/software and system calibration for remote temperature measurements. The charge was therefore to develop and demonstrate a multiband infrared imaging camera with the detectors simultaneously sensitive to multiple distinct color bands for front surface temperature measurements Wavelength ( m) measurements. Amongst the requirements are: that the measurement system will not affect target dynamics or response to the laser irradiation and that the simplest criterion for spectral band selection is to choose those practically feasible spectral bands that create the most contrast between the objects or scenes of interest in the expected environmental conditions. There is in the presentation a review of the modeling and simulation of multi-wave infrared temperature measurement and also a review of the detector development and QWIP capacities.

Bandara, Sumith V.; Gunapala, Sarath; Wilson, Daniel; Stirbl, Robert; Blea, Anthony; Harding, Gilbert

2006-01-01

461

Multiple protocol fluorometer and method  

DOEpatents

A multiple protocol fluorometer measures photosynthetic parameters of phytoplankton and higher plants using actively stimulated fluorescence protocols. The measured parameters include spectrally-resolved functional and optical absorption cross sections of PSII, extent of energy transfer between reaction centers of PSII, F.sub.0 (minimal), F.sub.m (maximal) and F.sub.v (variable) components of PSII fluorescence, photochemical and non-photochemical quenching, size of the plastoquinone (PQ) pool, and the kinetics of electron transport between Q.sub.a and PQ pool and between PQ pool and PSI. The multiple protocol fluorometer, in one embodiment, is equipped with an excitation source having a controlled spectral output range between 420 nm and 555 nm and capable of generating flashlets having a duration of 0.125-32 .mu.s, an interval between 0.5 .mu.s and 2 seconds, and peak optical power of up to 2 W/cm.sup.2. The excitation source is also capable of generating, simultaneous with the flashlets, a controlled continuous, background illumination.

Kolber, Zbigniew S. (Shoreham, NY); Falkowski, Paul G. (Stony Brook, NY)

2000-09-19

462

AC MultipleUnit Car Motor  

Microsoft Academic Search

A major factor in the development of the 4-motor equipment for use on a-c multiple-unit cars was the design of a suitable truck-mounted traction motor. Numerous electrical and mechanical problems had to be solved. The resultant design differs radically from the conventional axle-hung motor employed in such applications for the past 20 years. Preliminary operating experience indicates advantages comparable to

F. C. Kreitler

1951-01-01

463

Acquired Dysfibrinogenemia Secondary to Multiple Myeloma  

Microsoft Academic Search

Abnormal coagulation properties indicative of a dysfibrinogen were found in the plasma of a 72-year-old male with multiple myeloma (IgG?, stage IIIA). The patient had high paraprotein concentration (85.75 g\\/l) and prolonged thrombin time (76.8 s), activated partial thromboplastin time (39.5 s), prothrombin time (23.5 s) and reptilase time (72.0 s). The fibrinogen level was increased. The fibrin polymerization induced

Roman Kotlín; Tomáš Riedel; Peter Salaj; Zuzana Reicheltová; Pavel Májek; Tarek Khaznadar; Jan E. Dyr

2008-01-01

464

Asymptotic Analysis of Multiple Description Quantizers  

Microsoft Academic Search

A high rate analysis is presented for multiple description quantizers introducedin [1], for rth power distortions and general source densities. Both, fixedlength and variable length encoding of the quantizer indices are considered.Optimal companding functions are shown to be the same as for single channelquantizers. As compared to the bound in [2], a gap of 8.69 dB and 3.07 dB existsbetween

Vinay A. Vaishampayan; J.-C. Batllo

1998-01-01

465

Immunomodulatory drugs in multiple myeloma.  

PubMed

The introduction of new agents immunomodulatory drugs (IMiDs) and proteasome inhibitors has brought a major shift in therapeutic paradigm in the treatment of newly diagnosed and refractory multiple myeloma (MM). Thalidomide was the first immunomodulatory agent approved for use in myeloma. Although highly active, it is associated with considerable toxicity, particularly in older patients. Lenalidomide, an analog of thalidomide, was developed because of its more potent anti-MM activity and better toxicity profile than the parent compound. Since its introduction in 2004, lenalidomide has established a role in all phases of treatment in MM. The pleiotropic antitumor effects of lenalidomide have translated into clinical efficacy in diseases other than MM. Pomalidomide is a highly potent third-generation IMiD that shares similar pharmacologic properties as thalidomide, with very promising activity in MM and myelofibrosis. This review summarizes the mechanisms of action and clinical activity of IMiDs in MM. PMID:23373782

Andhavarapu, Swati; Roy, Vivek

2013-02-01

466

Multiplicity in 5 Msolar stars  

NASA Astrophysics Data System (ADS)

Binary/multiple status can affect stars at all stages of their lifetimes: evolution onto the main sequence, properties on the main sequence, and subsequent evolution. 5 Msolar stars have provided a wealth of information about the binary properties fairly massive stars. The combination of cool evolved primaries and hot secondaries in Cepheids (geriatric B stars) have yielded detailed information about the distribution of mass ratios. and have also provided a surprisingly high fraction of triple systems. Ground-based radial velocity orbits combined with satellite data from Hubble, FUSE, IUE, and Chandra are needed to provide full information about the systems, including the masses. As a recent example, X-ray observations can identify low mass companions which are young enough to be physical companions. Typically binary status and properties (separation, eccentricity, mass ratio) determine whether any stage of evolution takes an exotic form.

Evans, Nancy Remage

2011-07-01

467

Multiplicity in 5 M_? Stars  

NASA Astrophysics Data System (ADS)

Multiwavelength opportunities have provided important new insights into the properties of binary/multiple 5 M_? stars. The combination of cool evolved primaries and hot secondaries in Cepheids (geriatric B stars) has yielded detailed information about the distribution of mass ratios. It has also provided a surprisingly high fraction of triple systems. Ground-based radial velocity orbits combined with satellite data from Hubble, FUSE, IUE, and Chandra can provide full information about the systems, including the masses. In particular, X-ray observations can identify low mass companions which are young enough to be physical companions. These multiwavelength observations provide important tests for star formation scenarios including differences between high and low mass results and differences between close and wide binaries.

Remage Evans, Nancy

2011-01-01

468

Multiple mechanisms modulate Brassinosteroid signaling  

PubMed Central

Brassinosteroids are essential hormones for plant growth and development. Genetic studies have identified key components of the BR signaling pathway, including the cell-surface receptor kinases that perceive BR, an intracellular kinase and a phosphatase, and nuclear transcription factors. Subsequent biochemical studies have revealed many details about signaling events from BR perception at the cell surface to gene expression in the nucleus. Recent studies have identified the 14-3-3 proteins as BR signaling components and elucidated multiple mechanisms by which phosphorylation modulates the BR transcription factors. In addition, BRI1 signaling from the endosomes and BR-independent functions of BAK1 have been observed. However, a major gap still exists in the current BR signaling pathway between the receptor complex and downstream signaling events.

Gendron, Joshua M.; Wang, Zhi-Yong

2007-01-01

469

Coherent and incoherent multiple scattering  

NASA Astrophysics Data System (ADS)

We compare two different models of transport of light in a disordered system with a spherical Gaussian distribution of scatterers. A coupled dipole model, taking into account all interference effects, is compared to an incoherent model, using a random walk of particles. Besides the well-known coherent backscattering effect and a well pronounced forward lobe, the incoherent model reproduces extremely well all scattering features. In an experiment with cold atoms, we use the momentum recoil imparted on the center of mass of the sample as a partial probe of the light-scattering properties. We find that the force acting on the center of mass of the atoms is not well suited to exhibit the coherence effects in light propagation under multiple-scattering conditions.

Chabé, Julien; Rouabah, Mohamed-Taha; Bellando, Louis; Bienaimé, Tom; Piovella, Nicola; Bachelard, Romain; Kaiser, Robin

2014-04-01

470

Multiple thoracolithiasis: An incidental finding  

PubMed Central

Thoracoliths are rare benign intrapleural fibrotic structures with a necrotic fat core. There are 19 previous reported cases in the literature. This case report presents for the first time, a patient with two thoracoliths within the same hemithorax. Both lesions were identified incidentally in the left hemithorax by computed tomography and remained in the same position on repeat imaging. The lesions were removed by a video-assisted thoracic surgery approach. Histology revealed a 20mm and a 14mm lesion, with a fibrotic dense collagen shell surrounding a non-viable necrotic fat core. This case demonstrates that thoracolithiasis is a rare differential diagnosis for incidental multiple non-mobile lesions within the thorax.

Rawstorne, E; Muzaffar, J; Hawari, M; Naidu, P; Steyn, R

2012-01-01

471

Multiple thoracolithiasis: An incidental finding.  

PubMed

Thoracoliths are rare benign intrapleural fibrotic structures with a necrotic fat core. There are 19 previous reported cases in the literature. This case report presents for the first time, a patient with two thoracoliths within the same hemithorax. Both lesions were identified incidentally in the left hemithorax by computed tomography and remained in the same position on repeat imaging. The lesions were removed by a video-assisted thoracic surgery approach. Histology revealed a 20mm and a 14mm lesion, with a fibrotic dense collagen shell surrounding a non-viable necrotic fat core. This case demonstrates that thoracolithiasis is a rare differential diagnosis for incidental multiple non-mobile lesions within the thorax. PMID:24960759

Rawstorne, E; Muzaffar, J; Hawari, M; Naidu, P; Steyn, R

2012-01-01

472

Standardized multiple output power supply  

NASA Technical Reports Server (NTRS)

A comprehensive program to develop a prototype model of a standardized multiple output power supply for use in space flight applications is described. The prototype unit was tested and evaluated to assure that the design would provide near optimum performance for the planned application. The prototype design used a dc-to-dc converter incorporating reqenerative current feedback with a time-ratio controlled duty cycle to achieve high efficiency over a wide variation of input voltage and output loads. The packaging concept uses a mainframe capable of accommodating up to four inverter/regulator modules with one common input filter and housekeeping module. Each inverter/regulator module provides a maximum of 100 watts or 10 amperes. Each module is adaptable to operate at any voltage between 4.0 volts and 108 volts. The prototype unit contains +5, + or - 15 and +28 volt modules.

Ragusa, E. V.

1975-01-01

473

Multiple-stage integrating accelerometer  

DOEpatents

An accelerometer assembly is provided for use in activating a switch in response to multiple acceleration pulses in series. The accelerometer includes a housing forming a chamber. An inertial mass or piston is slidably disposed in the chamber and spring biased toward a first or reset position. A damping system is also provided to damp piston movement in response to first and subsequent acceleration pulses. Additionally, a cam, including a Z-shaped slot, and cooperating follower pin slidably received therein are mounted to the piston and the housing. The middle or cross-over leg of the Z-shaped slot cooperates with the follower pin to block or limit piston movement and prevent switch activation in response to a lone acceleration pulse. The switch of the assembly is only activated after two or more separate acceleration pulses are sensed and the piston reaches the end of the chamber opposite the reset position.

Devaney, Howard F. (Cedar Crest, NM)

1986-01-01

474

Multiple-stage integrating accelerometer  

DOEpatents

An accelerometer assembly is provided for use in activating a switch in response to multiple acceleration pulses in series. The accelerometer includes a housing forming a chamber. An inertial mass or piston is slidably disposed in the chamber and spring biased toward a first or reset position. A damping system is also provided to damp piston movement in response to first and subsequent acceleration pulses. Additionally, a cam, including a Z-shaped slot, and cooperating follower pin slidably received therein are mounted to the piston and the housing. The middle or cross-over leg of the Z-shaped slot cooperates with the follower pin to block or limit piston movement and prevent switch activation in response to a lone acceleration pulse. The switch of the assembly is only activated after two or more separate acceleration pulses are sensed and the piston reaches the end of the chamber opposite the reset position.

Devaney, H.F.

1984-06-27

475

Multiple maize minichromosomes in meiosis.  

PubMed

In this study, four distinct minichromosomes derived from the maize B chromosome, were increased in copy number using the B chromosome's accumulation mechanism, namely nondisjunction at the second pollen mitosis and preferential fertilization of the egg. These minichromosomes provide the unique opportunity to examine the behavior of many copies of a single chromosome in an otherwise diploid background. While multiple copies were associated in multivalent configurations, they often dissociated into univalents or bivalents prior to metaphase I. The largest mini's behavior closely resembled the progenitor B chromosome, but all smaller chromosomes showed failure of sister chromatid cohesion. In addition to the meiotic behavior, we observed many anomalies of univalent behavior and possible heterochromatic fusions of B repeat associated heterochromatin. PMID:22552914

Masonbrink, Rick E; Gaeta, Robert T; Birchler, James A

2012-05-01

476

Cognitive impairment in multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised by widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and neuropsychiatric symptoms, all of which can occur independently of one another. The common cognitive symptoms include deficits in complex attention, efficiency of information processing, executive func