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1

Multiple Indicators, Multiple Causes Measurement Error Models  

PubMed Central

Multiple Indicators, Multiple Causes Models (MIMIC) are often employed by researchers studying the effects of an unobservable latent variable on a set of outcomes, when causes of the latent variable are observed. There are times however when the causes of the latent variable are not observed because measurements of the causal variable are contaminated by measurement error. The objectives of this paper are: (1) to develop a novel model by extending the classical linear MIMIC model to allow both Berkson and classical measurement errors, defining the MIMIC measurement error (MIMIC ME) model, (2) to develop likelihood based estimation methods for the MIMIC ME model, (3) to apply the newly defined MIMIC ME model to atomic bomb survivor data to study the impact of dyslipidemia and radiation dose on the physical manifestations of dyslipidemia. As a by-product of our work, we also obtain a data-driven estimate of the variance of the classical measurement error associated with an estimate of the amount of radiation dose received by atomic bomb survivors at the time of their exposure. PMID:24962535

Tekwe, Carmen D.; Carter, Randy L.; Cullings, Harry M.; Carroll, Raymond J.

2014-01-01

2

Multiple indicators, multiple causes measurement error models.  

PubMed

Multiple indicators, multiple causes (MIMIC) models are often employed by researchers studying the effects of an unobservable latent variable on a set of outcomes, when causes of the latent variable are observed. There are times, however, when the causes of the latent variable are not observed because measurements of the causal variable are contaminated by measurement error. The objectives of this paper are as follows: (i) to develop a novel model by extending the classical linear MIMIC model to allow both Berkson and classical measurement errors, defining the MIMIC measurement error (MIMIC ME) model; (ii) to develop likelihood-based estimation methods for the MIMIC ME model; and (iii) to apply the newly defined MIMIC ME model to atomic bomb survivor data to study the impact of dyslipidemia and radiation dose on the physical manifestations of dyslipidemia. As a by-product of our work, we also obtain a data-driven estimate of the variance of the classical measurement error associated with an estimate of the amount of radiation dose received by atomic bomb survivors at the time of their exposure. PMID:24962535

Tekwe, Carmen D; Carter, Randy L; Cullings, Harry M; Carroll, Raymond J

2014-11-10

3

Combining Multiple Indicators to Determine Conservation Status  

E-print Network

Combining Multiple Indicators to Determine Conservation Status Based on Expert Preferences of Resource Management (Planning) Title of Project: Combining multiple indicators to determine conservation on using multiple indicators, and most methods for combining indicators either assume that all indicators

4

Multiplication  

NSDL National Science Digital Library

How sharp are your multiplication skills? Give these great math games a try ! Play Asteroids blaster and test your multiplication skills. How fast can you solve the problem... play a round of Baseball multiplication and see! Multiplication is fun and delicious with Crazy Cones. Help Lemonade Larry determine the correct amount! Test your multiplication skills with Tic Tac Toe! ...

Ms.Roberts

2009-02-24

5

Multiplication  

NSDL National Science Digital Library

Here are some fun games to make practicing multiplication fun!!! Before you start the fun... click Multiplication Tables to review what you already know! Can you figure out the Multiplication Hidden Picture... you better know your math skills first or the picture will burst! It\\'s times to have a \\"blast\\"... Blow me away with theMultiplication Tunnel Blaster Now your ready to join the team! Show me ...

Walker, Ms.

2008-03-26

6

Estimating differential expression from multiple indicators  

PubMed Central

Regardless of the advent of high-throughput sequencing, microarrays remain central in current biomedical research. Conventional microarray analysis pipelines apply data reduction before the estimation of differential expression, which is likely to render the estimates susceptible to noise from signal summarization and reduce statistical power. We present a probe-level framework, which capitalizes on the high number of concurrent measurements to provide more robust differential expression estimates. The framework naturally extends to various experimental designs and target categories (e.g. transcripts, genes, genomic regions) as well as small sample sizes. Benchmarking in relation to popular microarray and RNA-sequencing data-analysis pipelines indicated high and stable performance on the Microarray Quality Control dataset and in a cell-culture model of hypoxia. Experimental-data-exhibiting long-range epigenetic silencing of gene expression was used to demonstrate the efficacy of detecting differential expression of genomic regions, a level of analysis not embraced by conventional workflows. Finally, we designed and conducted an experiment to identify hypothermia-responsive genes in terms of monotonic time-response. As a novel insight, hypothermia-dependent up-regulation of multiple genes of two major antioxidant pathways was identified and verified by quantitative real-time PCR. PMID:24586062

Ilmjärv, Sten; Hundahl, Christian Ansgar; Reimets, Riin; Niitsoo, Margus; Kolde, Raivo; Vilo, Jaak; Vasar, Eero; Luuk, Hendrik

2014-01-01

7

Should researchers use single indicators, best indicators, or multiple indicators in structural equation models?  

PubMed Central

Background Structural equation modeling developed as a statistical melding of path analysis and factor analysis that obscured a fundamental tension between a factor preference for multiple indicators and path modeling’s openness to fewer indicators. Discussion Multiple indicators hamper theory by unnecessarily restricting the number of modeled latents. Using the few best indicators – possibly even the single best indicator of each latent – encourages development of theoretically sophisticated models. Additional latent variables permit stronger statistical control of potential confounders, and encourage detailed investigation of mediating causal mechanisms. Summary We recommend the use of the few best indicators. One or two indicators are often sufficient, but three indicators may occasionally be helpful. More than three indicators are rarely warranted because additional redundant indicators provide less research benefit than single indicators of additional latent variables. Scales created from multiple indicators can introduce additional problems, and are prone to being less desirable than either single or multiple indicators. PMID:23088287

2012-01-01

8

Differential Item Functioning Detection Using the Multiple Indicators, Multiple Causes Method with a Pure Short Anchor  

ERIC Educational Resources Information Center

The multiple indicators, multiple causes (MIMIC) method with a pure short anchor was proposed to detect differential item functioning (DIF). A simulation study showed that the MIMIC method with an anchor of 1, 2, 4, or 10 DIF-free items yielded a well-controlled Type I error rate even when such tests contained as many as 40% DIF items. In general,…

Shih, Ching-Lin; Wang, Wen-Chung

2009-01-01

9

Identifying node role in social network based on multiple indicators.  

PubMed

It is a classic topic of social network analysis to evaluate the importance of nodes and identify the node that takes on the role of core or bridge in a network. Because a single indicator is not sufficient to analyze multiple characteristics of a node, it is a natural solution to apply multiple indicators that should be selected carefully. An intuitive idea is to select some indicators with weak correlations to efficiently assess different characteristics of a node. However, this paper shows that it is much better to select the indicators with strong correlations. Because indicator correlation is based on the statistical analysis of a large number of nodes, the particularity of an important node will be outlined if its indicator relationship doesn't comply with the statistical correlation. Therefore, the paper selects the multiple indicators including degree, ego-betweenness centrality and eigenvector centrality to evaluate the importance and the role of a node. The importance of a node is equal to the normalized sum of its three indicators. A candidate for core or bridge is selected from the great degree nodes or the nodes with great ego-betweenness centrality respectively. Then, the role of a candidate is determined according to the difference between its indicators' relationship with the statistical correlation of the overall network. Based on 18 real networks and 3 kinds of model networks, the experimental results show that the proposed methods perform quite well in evaluating the importance of nodes and in identifying the node role. PMID:25089823

Huang, Shaobin; Lv, Tianyang; Zhang, Xizhe; Yang, Yange; Zheng, Weimin; Wen, Chao

2014-01-01

10

Indicators of Multiplicative Reasoning among Fourth Grade Students  

ERIC Educational Resources Information Center

Many students encounter difficulty in their transition to advanced mathematical thinking. Such difficulty may be explained by a lack of understanding of many concepts taught in early school years, especially multiplicative reasoning. Advanced mathematical thinking depends on the development of multiplicative reasoning. The purpose of this study…

Carrier, James A.

2010-01-01

11

A multiple indicator, multiple cause method for representing social capital with an application to psychological distress  

NASA Astrophysics Data System (ADS)

This paper describes a structural equation methodology for obtaining social capital scores for survey subjects from multiple indicators of social support, neighbourhood and trust perceptions, and memberships of organizations. It adjusts for variation that is likely to occur in levels of social capital according to geographic context (e.g. level of area deprivation, geographic region, level of urbanity) and demographic group. Social capital is used as an explanatory factor for psychological distress using data from the 2006 Health Survey for England. A highly significant effect of social capital in reducing the chance of psychiatric caseness is obtained after controlling for other individual and geographic risk factors. Allowing for social capital has considerable effects on the impacts on psychiatric health of other risk factors. In particular, the impact of area deprivation category is much reduced. There is also evidence of significant differentiation in social capital between population categories and geographic contexts.

Congdon, Peter

2010-03-01

12

Indicators of Multiple Personality Disorder for the Clinician.  

ERIC Educational Resources Information Center

Multiple personality disorder (MPD) is now recognized as a valid diagnostic category. Occurrence may be higher than previously suspected. While physiological testing of MPD has shown significant differences between the various personalities of individuals in terms of galvanic skin response, electroencephalogram recordings, electrodermal response…

Dalton, Thomas W.

13

Multiple uses of indicators and indices in cumulative effects assessment and management  

SciTech Connect

Both environmental indicators and multi-metric indices are useful for describing baseline conditions and qualitatively predicting the cumulative consequences of multiple actions. Several examples and case studies associated with indicators and/or indices are presented herein. They can be easily modified for usage in CEAM. Habitat suitability models reflect special indices related to habitat needs and quality for specific species or broad habitat types. Such models have been used to address direct and indirect effects, and with some modification, they can be also used to address cumulative effects of multiple actions. This review has indicated that there are numerous examples of such tools which have been or could be used in both EIA and CEAM. Some key lessons are: (1) in conducting CEAM studies, it is useful to think from the mindset that 'I am the VEC or indicator, and what is my historical and current condition and how have I, or will I, be affected by multiple past, present, and future actions?'; (2) due to the likely absence of detailed information on future actions, the described tools can still be used to 'predict' future conditions by focusing on qualitative up-or-down changes in individual indicators or indices with their aggregated displays; and (3) numerous regional and site-specific tools are currently available, with one example being indices of biological integrity for specific watersheds and water bodies. Such tools, even though they may not have been developed for CEAM usage, can certainly benefit CEAM studies and practice. Finally, usage of selected and appropriate tools as described herein can aid in conducting science-based, systematic, and documentable CEAM studies.

Canter, L.W., E-mail: envimptr@aol.com [University of Oklahoma and Environmental Impact Training, Horseshoe Bay, TX (United States); Atkinson, S.F. [Institute of Applied Science, University of North Texas, Denton, TX (United States)

2011-09-15

14

Learning about Locomotion Patterns: Effective Use of Multiple Pictures and Motion-Indicating Arrows  

ERIC Educational Resources Information Center

This study investigated how enriching visualizations with arrows indicating the motion of objects may help in conveying dynamic information: Multiple static-simultaneous visualizations with motion-indicating arrows were compared with either multiple visualizations without arrows or a single visualization with arrows. Seventy-one students were…

Imhof, Birgit; Scheiter, Katharina; Edelmann, Jorg; Gerjets, Peter

2013-01-01

15

Multiplication 2  

NSDL National Science Digital Library

Try some harder multiplication activities! Missing Factor Meteor Blasting Complete the Missing Step Batter s Up Multiplication Sum Sense Multiplication Challenge a Friend to Grand Prix Multiplication Double Digit Multiplication https://embed.espresso.co.uk/espresso/embed/images/logo_espresso.gif ) no-repeat center center"

Lerdahl, Miss

2010-11-16

16

Multiplication table  

NSDL National Science Digital Library

Help learn First learn go over your Learn The Multiplication table now get some extra help Learn The Multiplication table have fun Learn The multiplication table with games good luck practice test pre test pre test final test ...

Bgross

2011-04-14

17

Multiplication Rocks!!!  

NSDL National Science Digital Library

Let's practice what we've learned about multiplication. Play at least one game in each of the categories. Times Table Practice: Design the Ultimate Fashion Outfit with Math Models Blast the Meteors before they destroy the ship in Meteor Multiplication More Multiplication: Batter's Up in Baseball Multiplication Win $1,000,000 in Who Wants To Be A Millionaire? ...

Peake, Mrs.

2009-04-15

18

Multiplication Maddness!  

NSDL National Science Digital Library

Review your multiplication skills with these fun and exciting games! To excercise your brain, start with a review of your multiplication facts with Matching Multiplication! Step up to the plate and use your best swing! It\\'s time to play Batter s Up Baseball! Battle through the multiplication problems to save the princess. Begin your journey of Castle Quest! ...

Morgan, Ms.

2008-04-03

19

Multiplication Practice  

NSDL National Science Digital Library

Practice Your Multiplication Skills! Watch These Fun Multiplication Videos *Need a review? Watch the Multiplication is Repeated Addition Video Four Legged Zoo I ve Got 6 Ready or Not Here I Come (5s) Twelve Toes Elementary My Dear 2s Figure 8 Lucky 7s Video My Hero Zero Naughty Number 9 Practice your multiplication skills with these fun games: Multiplication Facts Become the king of multiplication with Castle Quest Dish up some ice cream with Crazy Cone Multiplication. Earn disco moves to make a dinosaur dance with Disco Dino. Design your own granny and make her race in a ...

Miss Lerdahl

2010-02-23

20

Performance evaluation of tacit knowledge management based on multiple indicator ideal interval methods  

Microsoft Academic Search

Based on the characteristic of tacit knowledge management and the methodology of enterprise performance evaluation, an evaluation indicator system for the management performance of tacit knowledge is set up in this paper. Then a new method of performance evaluation of knowledge management named as multiple indicator ideal interval methods is proposed. In the end, a company is taken as an

Tian Lan; Runtong Zhong; Hong Dai

2008-01-01

21

Effects of Indicator Transform Method of Electric Resistivity Data on Rock Mass Classification Using Multiple Indicator Kriging  

NASA Astrophysics Data System (ADS)

This study investigates the effects of indicator transform method of electric resistivity data on rock mass classification using multiple indicator kriging. Two different approaches were designed to examine the variation of rock mass classifications according to each indicator transform method. One approach is to change fuzzy membership functions for determining the indicator values at four increasing thresholds (i.e., 20, 40, 60 and 80 which represent the boundary values of rock mass classes in RMR). The other is to reclassify indicator transform ranges of electric resistivity data by considering various classification rules such as quantile, equal interval, natural breaks, standard deviation and grade block. Two tunnelling sites in Korea were selected as study areas, and multiple indicator kriging using borehole RMR and electric resistivity data was performed to estimate RMR values along planned tunnel alignments. The results showed that rock mass classes determined by multiple indicator kriging are significantly sensitive to both the fuzzy membership functions and the transform ranges. From validation processes, it was found that combination of the indicator values derived from frequency ratio of borehole RMR values at each rock mass class and the indicator transform ranges determined by the grade block can make a more accurate result than others.

Choi, Y.; Cho, J.; Park, H.; Bae, G.

2008-12-01

22

Gender and Perceived Illness Severity: Differential Indicators of Employment Concerns for Adults with Multiple Sclerosis?  

ERIC Educational Resources Information Center

Although research has indicated a link between gender and perceived illness severity and the employment status of people with multiple sclerosis (MS), it has not addressed questions regarding the relationship between those variables and specific types of employment concerns. In this study, a sample of 1,310 adults with MS replied to a mail survey…

Roessler, Richard T.; Turner, Ronna C.; Robertson, Judith L.; Rumrill,Phillip D.

2005-01-01

23

Child Sexual Abuse and Adult Romantic Adjustment: Comparison of Single- and Multiple-Indicator Measures  

ERIC Educational Resources Information Center

This study compared the usefulness of single- and multiple-indicator strategies in a model examining the role of child sexual abuse (CSA) to predict later marital satisfaction through attachment and psychological distress. The sample included 1,092 women and men from a nonclinical population in cohabiting or marital relationships. The single-item…

Godbout, Natacha; Sabourin, Stephane; Lussier, Yvan

2009-01-01

24

Human Health Risk Implications of Multiple Sources of Faecal Indicator Bacteria in a Recreational Waterbody  

EPA Science Inventory

We evaluate the influence of multiple sources of faecal indicator bacteria in recreational water bodies on potential human health risk by considering waters impacted by human and animal sources, human and non-pathogenic sources, and animal and non-pathogenic sources. We illustrat...

25

Parenting Multiples  

MedlinePLUS

... for parents of multiples can help, as can marriage counselors or clergy. It's important that you do ... and from early on it's apparent that their relationship is special. Parenting multiples has its ... reviewed: October 2013 Back

26

Finger Multiplication  

ERIC Educational Resources Information Center

Multiplication facts are difficult to teach. Therefore many researchers have put a great deal of effort into finding multiplication strategies. Sherin and Fuson (2005) provided a good survey paper on the multiplication strategies research area. Kolpas (2002), Rendtorff (1908), Dabell (2001), Musser (1966) and Markarian (2009) proposed the finger…

Simanihuruk, Mudin

2011-01-01

27

Kinetics of hepatic transport of 4-methylumbelliferone in rats. Analysis by multiple indicator dilution method  

Microsoft Academic Search

Hepatic elimination of 4-methylumbelliferone (4MU), which has been used as a model compound for conjugative metabolism, was studied by means of a multiple indicator dilution (MID) method in the isolated perfused rat liver. Using this method, three intrinsic hepatic clearances, CLint,inf, CLint,eff, and CLint,seq, which represent the influx, efflux, and sequestration processes, respectively, were obtained. When the dose was increased

Seiji Miyauchi; Yuichi Sugiyama; Yasufumi Sawada; Kaname Morita; Tatsuji Iga; Manabu Hanano

1987-01-01

28

Multiplication Mania!  

NSDL National Science Digital Library

Fun games to practice your multiplication facts! Need a refreshing break? Come on over to the lemonade stand...Lemonade Stand At the beach, you can swim, sun, and practice your multiplication facts...Beach Multiplication How fast are you? Click here to...Race the Clock Do you have your spacesuit and astronaut food, are you ready for your...Mission to the Moon ...

Hoeman, Ms.

2008-09-18

29

Multiplication Frenzy!  

NSDL National Science Digital Library

Let's practice multiplication! First, try to win the first place medal in the Fish Race. Then, test your skills by blowing up meteors by getting your multiplication tables right in Meteor Buster. Last, don't let the ants eat your lunch in The Ants Go Marching. ...

Burks, Ms.

2010-01-27

30

Indicators for cognitive performance and subjective cognitive complaints in multiple sclerosis: a role for advanced MRI?  

PubMed

Previous studies showed that advanced neuroimaging measures (functional MRI, diffusion tensor imaging) could distinguish multiple sclerosis (MS) patients with and without cognitive impairment. Are these measures indeed better indicators for cognitive impairment or subjective cognitive complaints than conventional MRI? Fifty MS patients and 29 controls were investigated. Regression analysis, including socio-demographic data, disease characteristics, psychological measures, and (advanced) neuroimaging, showed that worse cognitive performance was associated with male sex, lower education, and lower gray matter volume. Subjective cognitive complaints were associated with fatigue and less hippocampal atrophy. Advanced MRI measures did not add to the predictive power of our model. PMID:24277326

Hulst, Hanneke E; Gehring, Karin; Uitdehaag, Bernard Mj; Visser, Leo H; Polman, Chris H; Barkhof, Frederik; Sitskoorn, Margriet M; Geurts, Jeroen Jg

2013-11-25

31

Multiple Sclerosis  

MedlinePLUS

Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the ... and your body, leading to the symptoms of MS. They can include Visual disturbances Muscle weakness Trouble ...

32

Multiple myeloma  

MedlinePLUS

Plasma cell dyscrasia; Plasma cell myeloma; Malignant plasmacytoma; Plasmacytoma of bone; Myeloma - multiple ... myeloma most commonly causes a low red blood cell count ( anemia ), which can lead to fatigue and ...

33

Multiple Myeloma  

MedlinePLUS

... my-a-low-ma) is a kind of cancer in the bone marrow. Bone marrow is the tissue inside the bones where new blood cells are ... to take a very small sample of the tissue inside your bone. This is called a bone marrow aspiration. It can be done in your ... How is multiple myeloma treated? There is currently no cure for multiple myeloma. Treatment includes medicine to relieve ...

34

Monitoring marine recreational water quality using multiple microbial indicators in an urban tropical environment  

PubMed Central

The microbial water quality at two beaches, Hobie Beach and Crandon Beach, in Miami-Dade County, Florida, USA was measured using multiple microbial indicators for the purpose of evaluating correlations between microbes and for identifying possible sources of contamination. The indicator microbes chosen for this study (enterococci, Escherichia coli, fecal coliform, total coliform and C. perfringens) were evaluated through three different sampling efforts. These efforts included daily measurements at four locations during a wet season month and a dry season month, spatially intensive water sampling during low- and high-tide periods, and a sand sampling effort. Results indicated that concentrations did not vary in a consistent fashion between one indicator microbe and another. Daily water quality frequently exceeded guideline levels at Hobie Beach for all indicator microbes except for fecal coliform, which never exceeded the guideline. Except for total coliform, the concentrations of microbes did not change significantly between seasons in spite of the fact that the physical–chemical parameters (rainfall, temperature, pH, and salinity) changed significantly between the two monitoring periods. Spatially intense water sampling showed that the concentrations of microbes were significantly different with distance from the shoreline. The highest concentrations were observed at shoreline points and decreased at offshore points. Furthermore, the highest concentrations of indicator microbe concentrations were observed at high tide, when the wash zone area of the beach was submerged. Beach sands within the wash zone tested positive for all indicator microbes, thereby suggesting that this zone may serve as the source of indicator microbes. Ultimate sources of indicator microbes to this zone may include humans, animals, and possibly the survival and regrowth of indicator microbes due to the unique environmental conditions found within this zone. Overall, the results of this study indicated that the concentrations of indicator microbes do not necessarily correlate with one another. Exceedence of water quality guidelines, and thus the frequency of beach advisories, depends upon which indicator microbe is chosen. PMID:15261551

Shibata, Tomoyuki; Solo-Gabriele, Helena M.; Fleming, Lora E.; Elmir, Samir

2008-01-01

35

An earthquake detection algorithm with pseudo-probabilities of multiple indicators  

NASA Astrophysics Data System (ADS)

We develop an automatic earthquake detection algorithm combining information from numerous indicator variables in a non-parametric framework. The method is shown to perform well with multiple ratios of moving short- and long-time averages having ranges of time intervals and frequency bands. The results from each indicator are transformed to a pseudo-probability time-series (PPTS) in the range [0, 1]. The various PPTS of the different indicators are multiplied to form a single joint PPTS that is used for detections. Since all information is combined, redundancy among the different indicators produces robust peaks in the output. This allows the trigger threshold applied to the joint PPTS to be significantly lower than for any one detector, leading to substantially more detected earthquakes. Application of the algorithm to a small data set recorded during a 7-d window by 13 stations near the San Jacinto fault zone detects 3.13 times as many earthquakes as listed in the Southern California Seismic Network catalogue. The method provides a convenient statistical platform for including other indicators, and may utilize different sets of indicators to detect other information such as specific seismic phases or tremor.

Ross, Z. E.; Ben-Zion, Y.

2014-04-01

36

Using Support Vector Machines with Multiple Indices of Diffusion for Automated Classification of Mild Cognitive Impairment  

PubMed Central

Few studies have looked at the potential of using diffusion tensor imaging (DTI) in conjunction with machine learning algorithms in order to automate the classification of healthy older subjects and subjects with mild cognitive impairment (MCI). Here we apply DTI to 40 healthy older subjects and 33 MCI subjects in order to derive values for multiple indices of diffusion within the white matter voxels of each subject. DTI measures were then used together with support vector machines (SVMs) to classify control and MCI subjects. Greater than 90% sensitivity and specificity was achieved using this method, demonstrating the potential of a joint DTI and SVM pipeline for fast, objective classification of healthy older and MCI subjects. Such tools may be useful for large scale drug trials in Alzheimer's disease where the early identification of subjects with MCI is critical. PMID:22384251

O'Dwyer, Laurence; Lamberton, Franck; Bokde, Arun L. W.; Ewers, Michael; Faluyi, Yetunde O.; Tanner, Colby; Mazoyer, Bernard; O'Neill, Desmond; Bartley, Máiréad; Collins, D. Rónán; Coughlan, Tara; Prvulovic, David; Hampel, Harald

2012-01-01

37

Urinary excretion rates of multiple renal indicators after kidney transplantation: clinical significance for early graft outcome.  

PubMed

Post-reperfusion inflammation as well as anti-allograft response occur following kidney transplantation. We evaluated tissue damage by multiple renal indicators and searched for rejection predictors forewarning serum creatinine upturns. Twenty recipients (43 +/- 9 y; donors' age 35 +/- 16 y) of first renal grafts were studied. All through their hospital stay (35 +/- 18 d, range 17-75 d) we measured serum levels of urea, creatinine and electrolytes along with urinary excretion rates of total protein, albumin, enzymes (GGT, NAG, AAP) and electrolytes. During the period of observation, peaks were seen on the 1st day for serum creatinine, serum K+ and urine albumin output; on the 2nd day for urine Na+, GGT, AAP and protein excretion rates; on the 4th day for urea and creatinine outputs; on the 5th day for NAG output. On the 14th day, serum urea and creatinine as well as urine GGT, NAG, AAP, albumin and total protein were still elevated compared to 20 healthy control subjects. Delayed/slow graft function was observed in six recipients with higher pre-transplantation plasma lipids and lower donor HDL cholesterol. Hospital stay time was correlated with need for post-transplantation dialysis (p = 0.01) and recipient proteinuria by time 0 (TO) to day 3 (p = 0.02). Cold ischemia time was positively associated with 0-3 d serum creatinine, 0-3 d urinary urea and protein outputs (multiple r 0.9, p < 0.001). Multivariate analysis of longitudinal data showed that recipients' serum creatinine was positively correlated (p < 0.001) with urine AAP and negatively correlated with urine albumin, with diuresis volume and urine creatinine (p < 0.01). Serum creatinine elevations were preceded (previous 1-7 d) by increases in urinary indicators, the probability being higher in the presence of multiple simultaneous abnormalities. Useful parameters predictive of favorable graft outcome prior to transplantation included a brief cold ischemia time and a normal donor/recipient serum lipoprotein profile. Following transplantation, useful parameters were a high diuresis volume at time zero along with low urine NAG and high albumin outputs; early (first opst-graft 3 d) polyuria, low urea and GGT, high K, NAG and total protein excretions. PMID:9574459

Matteucci, E; Carmellini, M; Bertoni, C; Boldrini, E; Mosca, F; Giampietro, O

1998-03-01

38

Multiplication Madness  

NSDL National Science Digital Library

Get ready for some multplication fun! Test your skills with Go Granny Go!. If you are ready for a challenge, try Jungle Jim goes fishing. Send a knight flying with your knowledge of multiplication facts in Knight Fight! If you are feeling really smart, try Knight Quest. Have some fun with Wack a Mole and Workin Out with Wade! ...

Chase, Ms.

2010-11-12

39

Multiplication Madness!  

NSDL National Science Digital Library

Practice multiplying with these fun math games! Warm up your multiplication skills with Jungle Jim as you help him multiply with the monkeys! Begin with multiplying by 2 and move up. Next, quench your thirst with the Lemonade Game as you help calculate how much money you should get for each cup of lemonade you sell. Use the number keys ...

Schieffer, Miss

2009-04-21

40

Multiple Sclerosis.  

ERIC Educational Resources Information Center

This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

Plummer, Nancy; Michael, Nancy, Ed.

41

Lattice Multiplication  

NSDL National Science Digital Library

Leonardo Fibonacci's multiplication algorithm arrays the digits of multiplicands along a rectangular lattice. Read an explanation of the technique, see a few worked examples, and watch the method in action with a Java applet. Clicking a little off-center of any digit of a multiplicand (left to increase, right to decrease) instantly changes resulting products and sums throughout the lattice.

Interactive Math Miscellany And Puzzles, Alexander B.

2011-01-01

42

Multiple Pregnancy  

MedlinePLUS Videos and Cool Tools

... be looking for, and will explore the statistics, health and psychological risks to parents, children and siblings, and other issues ... are receiving infertility treatment, which carries a higher risk of multiple pregnancy ... to US health statistics, The twin birth rate has increased by ...

43

Multiples Grid  

NSDL National Science Digital Library

This problem reinforces a learner's understanding of factors and multiples. Students are presented with the hundred grid or parts of the grid where specific numbers have been shaded and must find out which factors have been chosen in order to produce the shading. A link to a spreadsheet which shades the squares according to the chosen factors, can be used by students to check their hypotheses. The Teachers' Notes page offers rationale, suggestions for implementation, discussion questions, and ideas for extension and support.

44

Multiplication Mania!  

NSDL National Science Digital Library

You\\'ve been practicing your multiplication facts, these games will help you develop your skills! First, you will read some stories that may help you remember your 9 X Tables better. Read through these stories and pick your favorite to share with a partner sitting close to you. Click here 9 X Tables Stories With this game, you need to save the mokeys apples so the crocodile wont eat ...

Reeves, Mrs.

2006-11-06

45

Multiple Personality Disorder: A Risk Indicator, Diagnostic Marker and Psychiatric Outcome for Severe Child Abuse  

Microsoft Academic Search

Recent studies suggest that multiple personality disorder (MPD) is not as rare as previously believed. Indeed, it may represent a relatively common (as many as 25% of cases) outcome of severe physical and sexual abuse of children. Because diagnosis and treatment offer the best prognosis, it is important for the pediatric clinician to become familiar with both the at risk

Barbara Y. Whitman; Wayne Munkel

1991-01-01

46

Kinetic analysis of pulmonary neutrophil retention in vivo using the multiple-indicator-dilution technique.  

PubMed

Multiple-indicator-dilution experiments were performed in the lungs of 13 anesthetized dogs by simultaneous bolus injection of 111In-labeled neutrophils, 51Cr-labeled red blood cells, and Evans blue-labeled albumin. Concomitant counts of unlabeled neutrophils were similar in pulmonary artery and aortic blood samples, demonstrating a dynamic balance across the lungs in the physiological state. Outflow profiles of labeled neutrophils were analyzed on the basis of a recirculatory pharmacokinetic model of labeled albumin. The outflow profiles of the recovered neutrophils were composed of a throughput component of circulating neutrophils and a component of reversibly marginated neutrophils. They were interpreted by a model incorporating neutrophil margination (transfer coefficient = 0.195 +/- 0.081 s-1), rapid demargination (0.054 +/- 0.027 s-1), and transfer to a slow marginated pool (0.023 +/- 0.018 s-1). It will be interesting to apply the analysis in future studies aimed at determining whether it could be a useful research tool to investigate the interactions between the pulmonary endothelium and neutrophils in physiological and diseased states. PMID:12639849

Schwab, Andreas J; Salamand, Agnes; Merhi, Yahye; Simard, Andre; Dupuis, Jocelyn

2003-07-01

47

Information processing and magnetic resonance imaging indices of brain pathology in multiple sclerosis.  

PubMed

Accumulation of central nervous system (CNS) pathology affects cognitive processing speed and efficiency and is thought to underlie attentional and executive deficits in multiple sclerosis (MS). Most clinical neuropsychological tests are multifactorial and are limited in their sensitivity to specific cognitive processes. This may, in part, account for the low to moderate correlations between clinical test results and magnetic resonance imaging (MRI) indices of brain pathology. We compared the ability of a clinical and an experimental test of cognitive processing speed to differentiate domain-specific cognitive changes in MS, and examined relations between test performance and MRI measures of brain pathology. Twelve MS patients and 12 controls completed the Paced Auditory Serial Addition Test (PASAT) and the Attention Networks Test-Interactions (ANT-I), a computerized response latency task. Subjects also had MRI scans that included T1, T2, and fluid-attenuated inversion recovery (FLAIR) sequences that provided global and localized volumetric measures. Patients made more errors on the PASAT and were slower on the ANT-I. The ANT-I also revealed specific deficits in response inhibition. In addition, ANT-I performance was associated with changes in a number of MRI measures, which was not the case for the PASAT. Reaction time paradigms that manipulate within-task demands on distinct cognitive functions may provide meaningful markers of brain disease burden in MS. PMID:24453738

Omisade, Antonina; Fisk, John D; Klein, Raymond M; Schmidt, Matthias; Darvesh, Sultan; Bhan, Virender

2012-01-01

48

A Multiple Indicators Multiple Cause (MIMIC) model of respiratory health and household factors in Chinese children: the seven Northeastern cities (SNEC) study.  

PubMed

In China, with the rapid economic development and improvement of living standards over the past few decades, the household living environment has shifted dramatically. The aim of the present study is to assess the impact of home environment factors on respiratory symptoms and asthma in Chinese children. Investigators analyzed data collected in the 25 districts from the seven Northeastern cities to examine health effects on respiratory symptoms and asthma in 31,049 children aged 2-14 years. Factor analysis was used to reduce 33 children's lifestyle and household variables to six new 'factor' variables. The multiple indicators multiple causes approach was used to examine the relationship between indoor air pollution and respiratory health status, controlling for covariates. Factor analyses generated six factor variables of potential household risk factors from an original list of 33 variables. The respiratory symptoms and asthma were significantly associated with the recent home renovation factor (estimate = 0.076, p < 0.001), pet ownership factor (estimate = 0.095, p < 0.001), environmental tobacco smoke (ETS) exposure factor (estimate = 0.181, p < 0.001) and PVC-flooring factor (estimate = 0.031, p = 0.007). Home ventilation factor was not related to any respiratory condition (estimate = 0.028, p = 0.074). Independent respiratory health effects existed for multiple household environmental factors recent home renovation, pet ownership, ETS, and PVC-flooring. PMID:23440490

Dong, Guang-Hui; Qian, Zhengmin; Fu, Qiang; Wang, Jing; Trevathan, Edwin; Ma, Wenjun; Liu, Miao-Miao; Wang, Da; Ren, Wan-Hui; Ong, Kee-Hean; Ferguson, Tekeda Freeman; Riley, Erin; Simckes, Maayan

2014-01-01

49

Multiple myeloma  

PubMed Central

Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. In this paper, we present a historically focused review of the disease, from the description of the first case in 1844 to the present. The evolution of drug therapy and stem-cell transplantation for the treatment of myeloma, as well as the development of new agents, is discussed. We also provide an update on current concepts of diagnosis and therapy, with an emphasis on how treatments have emerged from a historical perspective after certain important discoveries and the results of experimental studies. PMID:18332230

Rajkumar, S. Vincent

2008-01-01

50

STABILITY OF MULTIPLICATION OPERATORS AND MULTIPLICATION  

E-print Network

STABILITY OF MULTIPLICATION OPERATORS AND MULTIPLICATION SEMIGROUPS FATIH BAYAZIT, RETHA HEYMANN Abstract. We investigate uniform, strong, weak and almost weak stability of multiplication semigroups [13, Section 4] and [16]. Qualitative properties of such semigroups, e.g. various stability concepts

51

Modeling Multiplication with Fractions  

NSDL National Science Digital Library

Students will relate multiplication strategies with fractions through problem solving situations. This lesson connects prior understanding of multiplication and equal groups to multiplication of fractions.

Joseph Ratasky

2012-08-18

52

An Enriched Teaching Program For Reducing Resistance And Indices Of Unhappiness Among Individuals With Profound Multiple Disabilities  

Microsoft Academic Search

We evaluated an enriched teaching program for reducing resistance and indices of unhappiness displayed by 3 individuals with profound multiple disabilities during teaching sessions. The program involved presentation of preferred activities before, during, and after each teaching session, discontinuation of identified nonpreferred activities, and a brief break and preferred activity following occurrence of resistance. Implementation of the enriched teaching program

CAROLYN W. GREEN; DENNIS H. REID; JEANNIA H. ROLLYSON; SUSAN C. PASSANTE; Iser DeLeon

2005-01-01

53

Effects of Microswitch-Based Programs on Indices of Happiness of Students with Multiple Disabilities: A New Research Evaluation  

ERIC Educational Resources Information Center

The effects of microswitch-based programs on indices of happiness were evaluated with 9 students who had profound multiple disabilities. Each student received an ABAB sequence in which A represented baseline phases and B, intervention phases. During the latter phases, microswitches were used to enable the students to control preferred…

Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Didden, Robert; Oliva, Doretta; Severini, Laura; Smaldone, Angela; Tota, Alessia; Lamartire, Maria L.

2007-01-01

54

Multiple Episodes of Recent Gully Activity Indicated by Gully Fan Stratigraphy in Eastern Promethei Terra, Mars.  

NASA Astrophysics Data System (ADS)

Introduction Gullies are considered among the youngest geomorphic features on Mars based upon their stratigraphic relationships, superposition on steep slopes and distinctive morphology in unconsolidated sediment. Multiple formation hypotheses have been proposed, which can be divided into three broad classes: entirely dry mechanisms (e.g., [1,2]), wet mechanisms invoking groundwater or ground ice (e.g., [3,4]) and wet mechanisms invoking surficial meltwater (e.g., [5,6,7,8]). It has been difficult to differentiate between these hypotheses based upon past observations and it remains possible that gullies are polygenetic landforms. This study presents stratigraphic relationships in the depositional fan of a crater wall gully system that suggest: (1) multiple episodes of alluvial fan-style deposition, (2) very recent depositional activity that is younger than a newly recognized rayed crater, and (3) surficial snowmelt as the most likely source of these multiple episodes of recent gully activity. Gully-Fan Stratigraphy In Eastern Promethei Terra an ~5 km-diameter crater is observed with a well-developed gully system (Fig. 1) and several smaller gullies in its northnortheast wall. The large gully system (composed of a small western gully and larger eastern gully) shows evidence for incision into the crater wall country rock and has multiple contributory sub-alcoves and channels. The depositional fan associated with this gully system is bounded on its western side by a small arcuate ridge swell that is not observed on the eastern side of the fan. This ridge is interpreted as a moraine-like structure that may have bounded a glacially-formed depression into which the fan is deposited [8]. Similar depressions with bounding ridges are commonly observed in this latitude band (~30-50°S) in association with deeply incised gully alcoves [9,10,11]. This gully fan is composed of multiple lobes with distinct lobe contacts, incised channels, and cut-andfill deposits - all features similar to those seen in terrestrial alluvial fans [12,13]. The western portion of the fan is contained within the depression, while the younger eastern portion overlies and obscures any potential evidence of the ridge structure. A very striking and unusual feature of this gully fan is the large number of superposed impact craters; due to their density and similar diameter, we interpret these to be secondary craters from a large nearby primary impact crater. The depositional lobes of the fan can be divided into two groups: 1) those that predate the secondary crater population and 2) younger lobes that are superposed on the secondary craters. Numerous secondary craters (~1-25 m-diameter) superpose the lowermost stratigraphic lobe (Fig. 1, A), while at least three younger lobes (Fig. 1, C1, D1, and D2) directly superpose the cratered lobe. The emplacement date of these secondaries provides a robust maximum age for the youngest lobes of this fan, and therefore the most recent fluvial activity of the gully. Most gullies either have no superposed impact craters [3,7] or are too small to date with any certainty using crater counts [14]. Therefore, locating and dating the parent impact crater of these secondaries is critical to constrain the chronology and origin of gully systems. Rayed-Crater Source of the Secondary Craters Regional reconnaissance for the origin of the secondary craters led to the discovery of a previously unidentified rayed crater complex (consisting of an ~18 km-diameter outer crater and an ~7 km-diameter inner crater) approximately 175 km southwest of the gully system. Distinctive rays are observed in THEMIS nighttime thermal inertia data, but are not observable as albedo contrasts in THEMIS visible data, consistent with other identifications of young rayed craters on Mars [15,16]. The rims of both craters are distinct and consistent with the morphology of very young impact craters on Mars. The inner crater has a greater depth to diameter ratio than the outer crater (0.121 compared to 0.073), consistent with young Martian craters [17]. Both the ou

Schon, S.; Head, J.; Fassett, C.

2008-09-01

55

Databased comparison of Sparse Bayesian Learning and Multiple Linear Regression for statistical downscaling of low flow indices  

NASA Astrophysics Data System (ADS)

SummaryThis study attempts to compare the performance of two statistical downscaling frameworks in downscaling hydrological indices (descriptive statistics) characterizing the low flow regimes of three rivers in Eastern Canada - Moisie, Romaine and Ouelle. The statistical models selected are Relevance Vector Machine (RVM), an implementation of Sparse Bayesian Learning, and the Automated Statistical Downscaling tool (ASD), an implementation of Multiple Linear Regression. Inputs to both frameworks involve climate variables significantly (? = 0.05) correlated with the indices. These variables were processed using Canonical Correlation Analysis and the resulting canonical variates scores were used as input to RVM to estimate the selected low flow indices. In ASD, the significantly correlated climate variables were subjected to backward stepwise predictor selection and the selected predictors were subsequently used to estimate the selected low flow indices using Multiple Linear Regression. With respect to the correlation between climate variables and the selected low flow indices, it was observed that all indices are influenced, primarily, by wind components (Vertical, Zonal and Meridonal) and humidity variables (Specific and Relative Humidity). The downscaling performance of the framework involving RVM was found to be better than ASD in terms of Relative Root Mean Square Error, Relative Mean Absolute Bias and Coefficient of Determination. In all cases, the former resulted in less variability of the performance indices between calibration and validation sets, implying better generalization ability than for the latter.

Joshi, Deepti; St-Hilaire, André; Daigle, Anik; Ouarda, Taha B. M. J.

2013-04-01

56

Evaluating multiple indices of agricultural water use efficiency and productivity to improve comparisons between sites and trends  

NASA Astrophysics Data System (ADS)

Approximately 70% of global available freshwater supplies are used in the agricultural sector. Increased demands for water to meet growing population food requirements, and expected changes in the reliability of freshwater supplies due to climate change, threaten the sustainability of water supplies worldwide - not only on farms, but in connected cities and industries. Researchers concerned with agricultural water use sustainability use a variety of theoretical and empirical measures of efficiency and productivity to gain insight into the sustainability of agricultural water use. However, definitions of measures, or indices, vary between different natural and political boundaries, across regions, states and nations and between their respective research, industry, and environmental groups. Index development responds to local data availability and local agendas, and there is debate about the validity of various indices. However, real differences in empirical index measures are not well-understood across the multiple disciplines that study agricultural water use, including engineering and hydrology, agronomy, climate and soil sciences, and economics. Nevertheless reliable, accessible, and generalizable indices are required for planners and policymakers to promote sustainable water use systems. This study synthesizes a set of water use efficiency and productivity indices based on academic, industry and government literature in California and Australia, two locations with similarly water-stressed and valuable agricultural industries under pressure to achieve optimal water use efficiency and productivity. Empirical data at the irrigation district level from the California San Joaquin Valley and Murray Darling Basin states of Victoria and New South Wales in Australia are used to compute indices that estimate efficiency, yield productivity, and economic productivity of agricultural water use. Multiple index estimates of same time-series data demonstrate historical spread in efficiency and productivity measures in different agricultural regions. Individual indices consistently over- or under- estimate trends in efficiency and productivity by their construction, and may provide inaccurate results in years with extreme climatic events, such as droughts. By treating multiple indices as an "ensemble" of measures, analogous to the treatment of multiple climate model predictions, this study quantifies likely "true" states of efficiency and productivity in the selected agricultural regions, and error in individual indices. While different individual indices are preferable at different scales, and relative to the quality of available input data, ensemble indices can be more reliably used in comparative study across different agricultural regions, and for prediction.

Levy, M. C.

2012-12-01

57

Ischemia modified albumin is an indicator of oxidative stress in multiple sclerosis  

PubMed Central

Introduction: Oligodendrocytes need iron in processes of energy generation and myelination. However, excessive levels of iron may exert iron induced oxidative stress and thus lead to tissue degeneration. Monitoring oxidative stress will be of paramount importance in follow-up of patients with many diseases including multiple sclerosis (MS). The aim of this study was to measure total anti-oxidative status (TAS), total oxidative status (TOS) and ischemia modified albumin (IMA) in stable relapse remitting MS (RRMS) patients. Materials and methods: Thirty-five RRMS patients (15 males and 20 females; median age 42 (20–55) years) and thirty-five age-sex matched healthy controls (13 males and 22 females; median age 37 (21–60) years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald. Results: IMA levels were significantly higher in RRMS patients (P < 0.001), while TAS and TOS did not show any significant difference between groups (P = 0.870 and P = 0.460, respectively). Conclusions: Our results suggest IMA as a more efficient serum marker than TAS and TOS in detecting the oxidative stress in MS patients. Serum oxidative stress markers should be included in future study protocols besides clinical and radiological parameters. PMID:25351357

Aydin, Ozgur; Ellidag, Hamit Yasar; Eren, Esin; Kurtulus, Fatma; Yaman, Aylin; Y?lmaz, Necat

2014-01-01

58

Factorial Invariance in Multiple Populations: A Multiple Testing Procedure  

ERIC Educational Resources Information Center

A multiple testing method for examining factorial invariance for latent constructs evaluated by multiple indicators in distinct populations is outlined. The procedure is based on the false discovery rate concept and multiple individual restriction tests and resolves general limitations of a popular factorial invariance testing approach. The…

Raykov, Tenko; Marcoulides, George A.; Millsap, Roger E.

2013-01-01

59

Indication of transverse radial flow in high-multiplicity proton-proton collisions at the Large Hadron Collider  

NASA Astrophysics Data System (ADS)

We analyze the measured spectra of ?±, K±, p(\\bar{p}) in proton-proton (pp) collisions at \\sqrt{s} = 0.9, 2.76 and 7 TeV in the light of blast-wave model to extract the transverse radial flow velocity and kinetic temperature at freeze-out for the system formed in pp collisions. The dependence of the blast-wave parameters on average charged particle multiplicity of event sample or the ‘centrality’ of collisions has been studied and compared with results of similar analysis in nucleus-nucleus (AA) and proton-nucleus (pA) collisions. We analyze the spectra of K_{s}^0, ?(\\bar{\\Lambda }) and ?- also to see the dependence of blast-wave description on the species of produced particles. Within the framework of the blast-wave model, the study reveals indication of collective behavior for high-multiplicity events in pp collisions at LHC. Strong transverse radial flow in high-multiplicity pp collisions and its comparison with that in pA and AA collisions match with predictions from a very recent theoretical work (Shuryak and Zahed 2013 arXiv:hep-ph/1301.4470) that addresses the conditions for applicability of hydrodynamics in pp and pA collisions.

Ghosh, Premomoy; Muhuri, Sanjib; Nayak, Jajati K.; Varma, Raghava

2014-03-01

60

Indication of transverse radial flow in high-multiplicity proton-proton collisions at the Large Hadron Collider  

E-print Network

We analyze the measured spectra of $\\pi^\\pm$, $K^\\pm$, $p$($\\bar p$) in $pp$ collisions at $\\sqrt {s}$ = 0.9, 2.76 and 7 TeV, in the light of blast-wave model to extract the transverse radial flow velocity and kinetic temperature at freeze-out for the system formed in $pp$ collisions. The dependency of the blast-wave parameters on average charged particle multiplicity of event sample or the `centrality' of collisions has been studied and compared with results of similar analysis in nucleus-nucleus ($AA$) and proton-nucleus ($pA$) collisions. We analyze the spectra of $K_{s}^0$, $\\Lambda$($\\bar \\Lambda$) and $\\Xi^-$ also to see the dependence of blast-wave description on the species of produced particles. Within the framework of the blast-wave model, the study reveals indication of collective behavior for high-multiplicity events in $pp$ collisions at LHC. Strong transverse radial flow in high multiplicity $pp$ collisions and its comparison with that in $pA$ and $AA$ collisions match with predictions from a very recent theoretical work [Shuryak and Zahed 2013 arXiv:1301.4470] that addresses the conditions for applicability of hydrodynamics in $pp$ and $pA$ collisions.

Premomoy Ghosh; Sanjib Muhuri; Jajati k. Nayak; Raghava Varma

2014-02-27

61

Become a Multiplication Wizard!  

NSDL National Science Digital Library

Practice all levels of basic multiplication facts. Are you a math magician? Practice how speedy you can be in Be A Math Magician!. Dress up and race granny in Granny Multiplication Race to make her go faster, answer the problems correctly. Multiplication that makes your mouth water. Multiplication Ice Cream Cones ...

Ms. Robinson

2010-01-27

62

ISIM3D: AN ANSI-C THREE-DIMENSIONAL MULTIPLE INDICATOR CONDITIONAL SIMULATION PROGRAM  

EPA Science Inventory

The indicator conditional simulation technique provides stochastic simulations of a variable that (i) honor the initial data and (ii) can feature a richer family of spatial structures not limited by Gaussianity. he data are encoded into a series of indicators which then are used ...

63

An Evaluation of Multiple Single-Case Outcome Indicators Using Convergent Evidence Scaling  

ERIC Educational Resources Information Center

The purpose of this article is to evaluate the consistency of five single-case outcome indicators, used to assess response-to-intervention data from a pilot Tier 2 reading intervention that was implemented at an elementary school. Using convergent evidence scaling, the indicators were converted onto a common interpretive scale for each case…

McGill, Ryan J.; Busse, R. T.

2014-01-01

64

Simultaneous modelling of multiple traffic safety performance indicators by using a multivariate generalized linear mixed model  

Microsoft Academic Search

Traffic safety in the UK is one of the increasing number of areas where central government sets targets based on 'outcome-focused' performance indicators (PIs). Judgments about such PIs are often based solely on rankings of raw indicators and simple league tables dominate centrally published analyses. There is a considerable statistical literature examining health and education issues which has tended to

Trevor C. Bailey; Paul J. Hewson

2004-01-01

65

Power of Alternative Fit Indices for Multiple Group Longitudinal Tests of Measurement Invariance  

E-print Network

a Monte Carlo simulation to examine the power of change in alternative fit indices to detect two types of measurement invariance, weak and strong, across a variety of manipulated study conditions including sample size, sample size ratio, lack...

Short, Stephen David

2014-05-31

66

Embryonic loss in iatrogenic multiples.  

PubMed

Spontaneous reduction of multiple gestational sacs occurs less often in pregnancies conceived as a result of ovulation induction and assisted reproductive technology compared with spontaneously conceived multiple pregnancies. Whereas most spontaneous multiple pregnancies are twin gestations, a higher proportion of multiple pregnancies that result from ovulation induction and assisted reproductive technology are triplet and higher-order gestations. Recent evidence, described in this article, indicates that although twin and higher-order multiple gestations found on initial ultrasound subsequently may undergo spontaneous reduction to singletons or twins, there may be important consequences for the outcome of the surviving fetus or fetuses. PMID:15644286

Dickey, Richard P

2005-03-01

67

A consistent picture of the hydroclimatic response to global warming from multiple indices: Models and observations  

NASA Astrophysics Data System (ADS)

analyze trends of six daily precipitation-based and physically interconnected hydroclimatic indices in an ensemble of historical and 21st century climate projections under forcing from increasing greenhouse gas (GHG) concentrations (Representative Concentration Pathways (RCP)8.5), along with gridded (land only) observations for the late decades of the twentieth century. The indices include metrics of intensity (SDII) and extremes (R95) of precipitation, dry (DSL), and wet spell length, the hydroclimatic intensity index (HY-INT), and a newly introduced index of precipitation area (PA). All the indices in both the 21st century and historical simulations provide a consistent picture of a predominant shift toward a hydroclimatic regime of more intense, shorter, less frequent, and less widespread precipitation events in response to GHG-induced global warming. The trends are larger and more spatially consistent over tropical than extratropical regions, pointing to the importance of tropical convection in regulating this response, and show substantial regional spatial variability. Observed trends in the indices analyzed are qualitatively and consistently in line with the simulated ones, at least at the global and full tropical scale, further supporting the robustness of the identified prevailing hydroclimatic responses. The HY-INT, PA, and R95 indices show the most consistent response to global warming, and thus offer the most promising tools for formal hydroclimatic model validation and detection/attribution studies. The physical mechanism underlying this response and some of the applications of our results are also discussed.

Giorgi, F.; Coppola, E.; Raffaele, F.

2014-10-01

68

Evaluating Multiple Indices from a Canopy Reflectance Sensor to Estimate Corn N Requirements  

Technology Transfer Automated Retrieval System (TEKTRAN)

With the increasing cost of fertilizer N, there is a renewed emphasis on developing new technologies for quantifying in-season N requirements for corn. The objectives of this research are (i) to evaluate different vegetative indices derived from an active reflectance sensor in estimating in-season N...

69

Weighting and Aggregation in Composite Indicator Construction: A Multiplicative Optimization Approach  

ERIC Educational Resources Information Center

Composite indicators (CIs) have increasingly been accepted as a useful tool for benchmarking, performance comparisons, policy analysis and public communication in many different fields. Several recent studies show that as a data aggregation technique in CI construction the weighted product (WP) method has some desirable properties. However, a…

Zhou, P.; Ang, B. W.; Zhou, D. Q.

2010-01-01

70

Inter-comparison of drought indicators derived from multiple precipitation datasets in Africa  

NASA Astrophysics Data System (ADS)

This study investigates the potential of implementing different drought indicators to improve drought monitoring capabilities at continental scale. Several global and continental datasets based on re-analysis, gridded observation, and remote sensing data were tested. At regional level the capabilities of each indicator and dataset on five regions on the African continent (Oum er-rbia, Blue Nile, Upper Niger, Limpopo and the Great Horn of Africa) were compared. The five precipitation datasets used were the ERA - Interim reanalysis (0.5°x0.5° resolution from 1979 to 2010), Tropical Rainfall Measuring Mission (TRMM) satellite monthly rainfall product 3B43 (0.25°x0.25° resolution from 1998 to 2010), the Global Precipitation Climatology Centre (GPCC) gridded precipitation dataset V.5 (1°x1° resolution from 1901 to 2010), the Global Precipitation Climatology Project (GPCP) Global Monthly Merged Precipitation Analyses (2.5°x2.5° resolution from 1979 to 2010), and the Climate Prediction Center Merged Analysis of Precipitation (CMAP, 2.5°x2.5° resolution from 1979 to 2010). The set of indicators proposed included Standardized Precipitation index (SPI), Standardized Precipitation-Evaporation Index (SPEI), Standardized Run-off index (SRI), Soil Moisture Anomalies (SMA). A comparison of the annual cycle and monthly precipitation time series shows a general agreement in the timing of the peaks including the Great Horn of Africa where there are two rainy seasons. The main differences are observed thus in the ability to represent the magnitude of the wet seasons and extremes. Moreover, for the areas that are under drought, all the datasets agree with the certain time of onset and recovery but there are sometimes disagreements on the area affected. The agreement between datasets depends on the threshold selected to define the drought conditions. The comparison between SPI estimations suggest that the main sources of uncertainties (due by lack of ground information, estimation algorithms, parameterization of the convection, etc.) are the differences in the precipitation datasets rather than the estimation of the distribution parameters that defines each indicator. Particularly, the estimations of the indicators over Central Africa reflect the high uncertainty present in the precipitation datasets.

Naumann, Gustavo; Dutra, Emanuel; Barbosa, Paulo; Pappenberger, Florian; Wetterhall, Fredrik

2013-04-01

71

Multiple climate indices of the Cenozoic sedimentary sequence in the western Tarim Basin, China  

NASA Astrophysics Data System (ADS)

The Tarim Basin is one of the largest closed basins in the word, and is a typical region that was affected directly by the retreat of the Tethyan Realm and the stepwise uplift of the Tibetan Plateau. In the western part, over 3000 m of Cenozoic sedimentary sequences, consisting of marine deposits in the lower, continental clay and fine sand in the middle, and molasse in the upper part, record the evolution of the eastern edge of the Tethyan Realm, the Asian aridification, and the deformation of the Pamir. In this work, we reported the high-resolution multi-proxy indices of the complete Cenozoic Ulukeqiati section from the westernmost of the Tarim Basin. Our results show: 1) variations in grain size, magnetic susceptibility and the ultrafine component, and magnetic susceptibility can be used as proxies for dynamics of transport medium, continental aridity, and temperature, respectively; 2) the long-term increase in mean size reflected an overall strengthen in potential energy to the transporting medium arised from tectonic activity and/or climate change, the long-term decrease in magnetic susceptibility and the ultrafine component proportion revealed an enhanced continental aridity, whilst, the long-term decrease in redness suggested a stepwise cooing process of the area during the Cenozoic; 3) comparison of the high resolution records with the geological events recorded in the same sedimentary sequence suggested that the retreat of the Tethyan Realm, the uplift of the Tibetan Plateau, and the Cenozoic global cooling played the leading roles in driving the Cenozoic Asian aridification.

Wang, Xin; Sun, Donghuai; Chen, Fahu; Wang, Fei; Li, Baofeng; Wu, Sheng; Zhang, Yuebao; Li, Zaijun

2013-04-01

72

Multiple-Ring Digital Communication Network  

NASA Technical Reports Server (NTRS)

Optical-fiber digital communication network to support data-acquisition and control functions of electric-power-distribution networks. Optical-fiber links of communication network follow power-distribution routes. Since fiber crosses open power switches, communication network includes multiple interconnected loops with occasional spurs. At each intersection node is needed. Nodes of communication network include power-distribution substations and power-controlling units. In addition to serving data acquisition and control functions, each node acts as repeater, passing on messages to next node(s). Multiple-ring communication network operates on new AbNET protocol and features fiber-optic communication.

Kirkham, Harold

1992-01-01

73

Multiple sclerosis - discharge  

MedlinePLUS

MS - discharge ... Your doctor has told you that you have multiple sclerosis. This disease affects the brain and spinal cord ( ... bladder is not working correctly. Some people with multiple sclerosis need to use a urinary catheter . This is ...

74

Multiplication as Replication  

NSDL National Science Digital Library

Students build tables and use patterns as an introduction to multiplication. They are encouraged to use multiplication by 10 or 100 for larger values as the beginnings of commutativity and distribution are introduced.

Wnet

2008-10-07

75

Jalyn's Multiplication Mania!  

NSDL National Science Digital Library

Multiplication Games For My Favorite Gillenwater Jalyn Will Love Serving Aliens Lunch! Ms. Gillenwater Will Have Fun With Multiplication In Murbia! When Jalyn Plays This Game She Will Go Bananas! Buy A Pet From Gillenwater s Pet Shop! ...

Huey, Mr.

2011-10-11

76

MAXIMUM MULTIPLE ATTENUATION  

Microsoft Academic Search

Recently Common Depth Point Stacking has become the general rule for seismic evaluation. Stack shooting is carried out to enhance the' primary event as well as to attenuate the multiple. Actual multiple attenuation can only take place providing the multiple event is stacked out of phase. Such out of stacking can only take place providing there is an increase of

W. HRYHOR

77

Performance of multiple pulse multiple delay modulated UWB signals in a multiple access indoor wireless channel  

Microsoft Academic Search

In this paper, the performance of a two user UWB multiple access (UWB-MA) system based on multiple-pulse multiple-delay (MPMD) modulation scheme in an indoor wireless channel is evaluated by computer simulations. The indoor multipart propagation channel model used in this study is based on the modified statistical Saleh-Valenzuela model proposed by Foerester and Li from Intel. The simulation results indicate

Faranak Nekoogar; Farid Dowla

2003-01-01

78

Multiple Core Galaxies  

NASA Technical Reports Server (NTRS)

Nuclei of galaxies often show complicated density structures and perplexing kinematic signatures. In the past we have reported numerical experiments indicating a natural tendency for galaxies to show nuclei offset with respect to nearby isophotes and for the nucleus to have a radial velocity different from the galaxy's systemic velocity. Other experiments show normal mode oscillations in galaxies with large amplitudes. These oscillations do not damp appreciably over a Hubble time. The common thread running through all these is that galaxies often show evidence of ringing, bouncing, or sloshing around in unexpected ways, even though they have not been disturbed by any external event. Recent observational evidence shows yet another phenomenon indicating the dynamical complexity of central regions of galaxies: multiple cores (M31, Markarian 315 and 463 for example). These systems can hardly be static. We noted long-lived multiple core systems in galaxies in numerical experiments some years ago, and we have more recently followed up with a series of experiments on multiple core galaxies, starting with two cores. The relevant parameters are the energy in the orbiting clumps, their relative.masses, the (local) strength of the potential well representing the parent galaxy, and the number of cores. We have studied the dependence of the merger rates and the nature of the final merger product on these parameters. Individual cores survive much longer in stronger background potentials. Cores can survive for a substantial fraction of a Hubble time if they travel on reasonable orbits.

Miller, R.H.; Morrison, David (Technical Monitor)

1994-01-01

79

Quantifying and modeling long-range cross correlations in multiple time series with applications to world stock indices  

NASA Astrophysics Data System (ADS)

We propose a modified time lag random matrix theory in order to study time-lag cross correlations in multiple time series. We apply the method to 48 world indices, one for each of 48 different countries. We find long-range power-law cross correlations in the absolute values of returns that quantify risk, and find that they decay much more slowly than cross correlations between the returns. The magnitude of the cross correlations constitutes “bad news” for international investment managers who may believe that risk is reduced by diversifying across countries. We find that when a market shock is transmitted around the world, the risk decays very slowly. We explain these time-lag cross correlations by introducing a global factor model (GFM) in which all index returns fluctuate in response to a single global factor. For each pair of individual time series of returns, the cross correlations between returns (or magnitudes) can be modeled with the autocorrelations of the global factor returns (or magnitudes). We estimate the global factor using principal component analysis, which minimizes the variance of the residuals after removing the global trend. Using random matrix theory, a significant fraction of the world index cross correlations can be explained by the global factor, which supports the utility of the GFM. We demonstrate applications of the GFM in forecasting risks at the world level, and in finding uncorrelated individual indices. We find ten indices that are practically uncorrelated with the global factor and with the remainder of the world indices, which is relevant information for world managers in reducing their portfolio risk. Finally, we argue that this general method can be applied to a wide range of phenomena in which time series are measured, ranging from seismology and physiology to atmospheric geophysics.

Wang, Duan; Podobnik, Boris; Horvati?, Davor; Stanley, H. Eugene

2011-04-01

80

A proposal of framework to obtain an integrated biodiversity indicator for agricultural ponds incorporating the simultaneous effects of multiple pressures  

Microsoft Academic Search

One of the promising approaches to monitoring biodiversity is assessing the status of pressures driving the biodiversity state. To achieve this, we need to identify the principal pressures that cause simultaneous biodiversity loss across taxonomic groups and clarify how multiple pressures act synergistically or at least simultaneously to decrease biodiversity in the focal ecosystem. Here, we used a series of

Taku Kadoya; Munemitsu Akasaka; Takashi Aoki; Noriko Takamura

2011-01-01

81

Long-Term Effects of the Family Bereavement Program on Multiple Indicators of Grief in Parentally Bereaved Children and Adolescents  

ERIC Educational Resources Information Center

Objectives: This article reports on results from a randomized experimental trial of the effects of the Family Bereavement Program (FBP) on multiple measures of grief experienced by parentally bereaved children and adolescents over a 6-year period. Method: Participants were 244 youths (ages 8-16, mean age = 11.4 years) from 156 families that had…

Sandler, Irwin N.; Ma, Yue; Tein, Jenn-Yun; Ayers, Tim S.; Wolchik, Sharlene; Kennedy, Cara; Millsap, Roger

2010-01-01

82

Long-Term Effects of the Family Bereavement Program on Multiple Indicators of Grief in Parentally Bereaved Children and Adolescents  

Microsoft Academic Search

Objectives: This article reports on results from a randomized experimental trial of the effects of the Family Bereavement Program (FBP) on multiple measures of grief experienced by parentally bereaved children and adolescents over a 6-year period. Method: Participants were 244 youths (ages 8–16, mean age = 11.4 years) from 156 families that had experienced the death of a parent. The

Irwin N. Sandler; Yue Ma; Jenn-Yun Tein; Tim S. Ayers; Sharlene Wolchik; Cara Kennedy; Roger Millsap

2010-01-01

83

The use of multiple indices of physiological activity to access viability in chlorine disinfected Escherichia coli O157:H7  

NASA Technical Reports Server (NTRS)

A suite of fluorescent intracellular stains and probes was used, in conjunction with viable plate counts, to assess the effect of chlorine disinfection on membrane potential (rhodamine 123; Rh123 and bis-(1,3-dibutylbarbituric acid) trimethine oxonol; DiBAC4(3)), membrane integrity (LIVE/DEAD BacLight kit), respiratory activity (5-cyano-2,3-ditolyl tetrazolium chloride; CTC) and substrate responsiveness (direct viable counts; DVC) in the commensal pathogen Escherichia coli O157:H7. After a 5 min exposure to the disinfectant, physiological indices were affected in the following order: viable plate counts > substrate responsiveness > membrane potential > respiratory activity > membrane integrity. In situ assessment of physiological activity by examining multiple targets, as demonstrated in this study, permits a more comprehensive determination of the site and extent of injury in bacterial cells following sublethal disinfection with chlorine. This approach to assessing altered bacterial physiology has application in various fields where detection of stressed bacteria is of interest.

Lisle, J. T.; Pyle, B. H.; McFeters, G. A.

1999-01-01

84

Fun with Multiplication Facts  

NSDL National Science Digital Library

We are going to practice our multiplication facts by having fun in the jungle! Drummin Up Our Multiplication Facts will help Jungle Jim as he beats his drums to learn his facts After you have helped Jungle Jim with his drums, join Jungle Jim and the Monkeys of Monamona while Swinging with Fact Families Memorize Multiplication Facts for extra practice after you have helped Jungle Jim! ...

Shields, Ms.

2007-10-25

85

Multiple antenna technologies  

E-print Network

Multiple antenna technologies have received high attention in the last few decades for their capabilities to improve the overall system performance. Multiple-input multiple-output systems include a variety of techniques capable of not only increase the reliability of the communication but also impressively boost the channel capacity. In addition, smart antenna systems can increase the link quality and lead to appreciable interference reduction.

Mohaisen, Manar; Chang, KyungHi

2009-01-01

86

Multiplication is Fun!  

NSDL National Science Digital Library

Let's play some multiplication games! If asked to pick a fact family or a leve, pick the one you are most comfortable with first then go to the harder one. Penguin Jump Click on the ice cube that has the answer to the multiplication problem at the bottom. Snagger s Pond For this game, first you will pick a Fact Family 0-5, 2-9, 3-12. Then answer the Multiplication fact. Let s Multiply! Select a level, then answer the multiplication facts by clicking on the ice cream ...

Miss Gross

2010-10-09

87

On Multiple-Layered Vortices  

NASA Technical Reports Server (NTRS)

As part of an ongoing effort to find ways to make vortex flow fields decompose more quickly, photographs and observations are presented of vortex flow fields that indicate the presence of multiple layers of fluid rotating about a common axis. A survey of the literature indicates that multiple-layered vortices form in waterspouts, tornadoes and lift-generated vortices of aircraft. An explanation for the appearance of multiple-layered structures in vortices is suggested. The observations and data presented are intended to improve the understanding of the formation and persistence of vortex flow fields.

Rossow, Vernon J.

2011-01-01

88

Using multiple chemical indicators to assess sources of nitrate and age of groundwater in a karstic spring basin  

USGS Publications Warehouse

Human health and ecological concerns have arisen due to a steady increase in nitrate-N concentrations during the past 40 years in Fannin Springs (0.3-4.7 mg/L), a regional discharge point with an average flow of >2.8 m3/second (>100 ft3/second) for water from the karstic Upper Floridan aquifer (UFA). Multiple chemical indicators (major dissolved species, 15N and 18O of nitrate, dissolved gases, 78 pesticides and degradates, and 67 organic compounds typically found in domestic and industrial wastewater) and transient tracers (3H/3He, chlorofluorocarbons [CFCs], sulfur hexafluoride [SF6]) were analyzed in water samples from nine wells along three transects and in spring water to assess groundwater age and potential contaminant sources. Land use is predominantly agricultural (52 percent) and forest (31 percent) in the 320 km2 (124 mi2) spring basin, which was delineated from a potentiometric-surface map of the UFA using high-resolution water-level data. Nitrate-N concentrations were highly variable in the oxic UFA and ranged from <0.02 to 4.7 mg/L. ?? 15N-NO3 values (3.4-9.9 per mil) indicated that nitrate contamination originated from inorganic sources (synthetic fertilizer) and organic sources (manure spreading or waste disposal). Higher nitrate concentrations and the younger age of spring water relative to water from upgradient wells indicate better communication with N sources at the surface. Apparent ages of groundwater correlated positively with well depth (P < 0.05) and were younger in water from wells nearer to the spring (<8 years) compared with other wells (10-50 years). Most transient tracer concentrations were consistent with binary mixing curves representing mixtures of water recharged during the past 10 years and older water (recharged before 1940). Young water mixing fractions ranged from 0.07 to 0.90. Trace levels of herbicides found in groundwater and spring water were indicative of applications for vegetative control in agricultural and other land-use types.

Katz, B.; Copeland, R.; Greenhalgh, T.; Ceryak, R.; Zwanka, W.

2005-01-01

89

Multiple density layered insulator  

DOEpatents

A multiple density layered insulator for use with a laser is disclosed wh provides at least two different insulation materials for a laser discharge tube, where the two insulation materials have different thermoconductivities. The multiple layer insulation materials provide for improved thermoconductivity capability for improved laser operation.

Alger, Terry W. (Tracy, CA)

1994-01-01

90

Constraining Multiple Grammars  

ERIC Educational Resources Information Center

This article offers the author's commentary on the Multiple Grammars (MG) language acquisition theory proposed by Luiz Amaral and Tom Roeper in the present issue. Multiple Grammars advances the claim that optionality is a constitutive characteristic of any one grammar, with interlanguage grammars being perhaps the clearest examples of a…

Hopp, Holger

2014-01-01

91

Detection by multiple trellises  

Microsoft Academic Search

In this paper, we present a novel pragmatic ap- proach, referred to as detection by multiple trellises, to perform trellis-based detection over realistic channels. More precisely, we consider channels with unknown parameters and apply the concept of detection by multiple trellises to forward-backward (FB) algorithms. The key idea of our approach consists, first, of properly quantizing the channel parameters and,

Michele Franceschini; Gian Luigi Ferrari; Riccardo Raheli

2009-01-01

92

Multiple Sclerosis Foundation  

MedlinePLUS

... iConquerMS initiative offers introductory webinar 1/27/2015 Multiple Sclerosis Coalition backs data-gathering bill 1/26/2015 ... Events View All Fundraising Events » 07 "Rocking Out Multiple Sclerosis" Concert feat. Nolan Neal in Copperhill, TN more ...

93

Combination of Multiple Searches  

Microsoft Academic Search

The TREC-3 project at Virginia Tech focused on methods for combining the evidence from multiple retrieval runs and queries to improve retrieval performance over any single retrieval method or query. The largest improvements result from the combination of retrieval paradigms rather than from the use of multiple similar queries.

Joseph A. Shaw; Edward A. Fox

1994-01-01

94

Multiple scattering technique lidar  

NASA Technical Reports Server (NTRS)

The Bernouilli-Ricatti equation is based on the single scattering description of the lidar backscatter return. In practice, especially in low visibility conditions, the effects of multiple scattering can be significant. Instead of considering these multiple scattering effects as a nuisance, we propose here to use them to help resolve the problems of having to assume a backscatter-to-extinction relation and specifying a boundary value for a position far remote from the lidar station. To this end, we have built a four-field-of-view lidar receiver to measure the multiple scattering contributions. The system has been described in a number of publications that also discuss preliminary results illustrating the multiple scattering effects for various environmental conditions. Reported here are recent advances made in the development of a method of inverting the multiple scattering data for the determination of the aerosol scattering coefficient.

Bissonnette, Luc R.

1992-01-01

95

Multiple sclerosis: symptomatic treatment.  

PubMed

Reports of new therapeutic agents designed to suppress inflammatory processes in multiple sclerosis have excited much interest but, thus far, have had little influence on symptoms, disability and handicap in patients. The clinical application of recent advances in physical, pharmacological and surgical approaches to management will, at least in the medium-term future, therefore offer significantly greater opportunities for improving the quality of life of patients with multiple sclerosis. Here, symptomatic treatment of the whole range of difficulties encountered by patients with multiple sclerosis is reviewed in the context of the multidisciplinary strategy crucial to an optimal outcome. PMID:8865021

Thompson, A J

1996-08-01

96

Low serum miR-19a expression as a novel poor prognostic indicator in multiple myeloma.  

PubMed

Multiple myeloma (MM) is the second most common hematologic malignancy characterized by the clonal expansion of plasma cells. Despite continuing advances, novel biomarkers are needed for diagnosis and prognosis of MM. In our study, we characterized the diagnostic and prognostic potential of circulating microRNAs (miRNAs) in MM. Serum miRNA levels were analyzed in 108 newly diagnosed symptomatic MM patients and 56 healthy donors (HDs). Our analysis identified 95 dysregulated miRNAs in newly diagnosed MM patients. Of the 95 dysregulated miRNAs, dysregulation of miR-19a, miR-92a, miR-214-3p, miR-135b-5p, miR-4254, miR-3658 and miR-33b was confirmed by quantitative reverse transcription PCR (RT-qPCR). Receiver operating characteristic analysis revealed that a combination of miR-19a and miR-4254 can distinguish MM from HD with a sensitivity of 91.7% and specificity of 90.5%. Decreased expression of miR-19a was positively correlated with international staging system advancement, del(13q14) and 1q21 amplification. Furthermore, downregulation of miR-19a resulted in significantly decreased progression-free survival (PFS) and overall survival (OS). Our analysis indicated that the poor prognostic correlation of miR-19a expression was independent of genetic abnormalities in MM. Multivariate analysis revealed that miR-19a was a significant predictor of shortened PFS and OS. Interestingly, although miR-19a levels portend a poor prognosis, patients with low miR-19a levels had an improved response to bortezomib compared to those with high miR-19a profile. Patients with downregulated miR-19a experienced a significantly extended survival upon bortezomib-based therapy. These data demonstrate that the expression patterns of serum microRNAs are altered in MM, and miR-19a levels are a valuable prognostic marker to identify high-risk MM. PMID:25220540

Hao, Mu; Zang, Meirong; Wendlandt, Erik; Xu, Yan; An, Gang; Gong, Dasen; Li, Fei; Qi, Fang; Zhang, Yanru; Yang, Ye; Zhan, Fenghuang; Qiu, Lugui

2015-04-15

97

Caring for Multiples  

MedlinePLUS

... NICU families. Mothering Multiples: Breastfeeding and Caring for Twins or More, by Karen Kerkhoff Gromada (La Leche League International, 1999). Mothers of Super Twins (MOST) A support network of families who have ...

98

Multiplication Series: Number Arrays  

NSDL National Science Digital Library

This one-page article describes and illustrates how arrays can be used to represent many number concepts, including building multiplication facts, commutativity, parity (odd/even), and exploring factors, prime numbers, and square numbers.

99

Multiple Myeloma Symptoms  

MedlinePLUS

... Stem Cell Transplants Allogeneic Stem Cell Transplants Autologous Stem Cell Transplants Bisphosphonates Radiation Therapy Surgery Alternative Therapies Treatment by Stage Treatment FAQs Clinical Trials Multiple Myeloma Cure Treatment Center Finder Speak to an MMRF nurse ...

100

Matrix Multiplication with CUDA  

NSDL National Science Digital Library

This module teaches matrix multiplication in the context of enumerating paths in a graph and the basics of programming in CUDA. It emphasizes the power of using shared memory when programming on GPGPU architectures.

Hochberg, Rob

101

Fertility Treatment and Multiples  

MedlinePLUS Videos and Cool Tools

... opportunities Advocacy in government For health professionals General health information I have personal experience with: Prematurity NICU experience Birth Defects High-risk pregnancy Loss Infertility Multiples None Of Above March ...

102

Multiple Principal Investigators  

Cancer.gov

Below is information to learn about NIH definitions, policies, and awards available to apply for support using the Multiple Principal Investigator (PI) model that supports team science. Answers to FAQs are included.

103

IRON IN MULTIPLE MYELOMA  

PubMed Central

Multiple myeloma is a non-curable B cell malignancy in which iron metabolism plays an important role. Patients with this disorder almost universally suffer from a clinically significant anemia, which is often symptomatic, and which is due to impaired iron utilization. Recent studies indicate that the proximal cause of dysregulated iron metabolism and anemia in these patients is cytokine-induced upregulation of hepcidin expression. Malignant myeloma cells are dependent on an increased influx of iron and therapeutic efforts are being made to target this requirement. The studies detailing the characteristics and biochemical abnormalities in iron metabolism causing anemia and the initial attempts to target iron therapeutically are described in this review. PMID:23879589

VanderWall, Kristina; Daniels-Wells, Tracy R; Penichet, Manuel; Lichtenstein, Alan

2013-01-01

104

Mobile multiple access study  

NASA Technical Reports Server (NTRS)

Multiple access techniques (FDMA, CDMA, TDMA) for the mobile user and attempts to identify the current best technique are discussed. Traffic loading is considered as well as voice and data modulation and spacecraft and system design. Emphasis is placed on developing mobile terminal cost estimates for the selected design. In addition, design examples are presented for the alternative techniques of multiple access in order to compare with the selected technique.

1977-01-01

105

Cannabinoids and Multiple Sclerosis  

Microsoft Academic Search

This review discusses clinical and preclinical evidence that supports the use of cannabinoid receptor agonists for the management\\u000a of multiple sclerosis. In addition, it considers preclinical findings that suggest that as well as ameliorating signs and\\u000a symptoms of multiple sclerosis, cannabinoid CB1 and\\/or CB2 receptor activation may suppress some of the pathological changes that give rise to these signs and

Roger G. Pertwee

2007-01-01

106

Multiplicities of dihedral discriminants  

Microsoft Academic Search

Given the discriminant {d_k} of a quadratic field k, the number of cyclic relative extensions N\\\\vert k of fixed odd prime degree p with dihedral absolute Galois group of order 2p, which share a common conductor f, is called the multiplicity of the dihedral discriminant {d_N} = {f^{2(p - 1)}}d_k^p . In this paper, general formulas for multiplicities of dihedral

Daniel C. Mayer

1992-01-01

107

Angiogenesis and Multiple Myeloma  

Microsoft Academic Search

The bone marrow microenvironment in multiple myeloma is characterized by an increased microvessel density. The production\\u000a of pro-angiogenic molecules is increased and the production of angiogenic inhibitors is suppressed, leading to an “angiogenic\\u000a switch”. Here we present an overview of the role of angiogenesis in multiple myeloma, the pro-angiogenic factors produced\\u000a by myeloma cells and the microenvironment, and the mechanisms

Nicola Giuliani; Paola Storti; Marina Bolzoni; Benedetta Dalla Palma; Sabrina Bonomini

108

Multiple Birth and Cut Algorithm for Multiple Object Detection  

E-print Network

Multiple Birth and Cut Algorithm for Multiple Object Detection Ahmed Gamal-Eldin, Xavier Descombes.zerubia}@inria.fr Abstract--In this paper, we describe a new optimization method which we call Multiple Birth and Cut (MBC). It combines the recently developed Multiple Birth and Death (MBD) algorithm and the Graph-Cut algorithm. MBD

Boyer, Edmond

109

Multiple Meaning Words  

NSDL National Science Digital Library

In this lesson, students will explore the concept that many words have multiple meaning. The students will be engaged in activities where they will use reference materials to look up the various definitions of the words and identify their parts of speech, as well as understand how the meaning of the words change depending on the context of the sentence. Students will compose sentences for words with multiple meanings, as well as write a riddle where both definitions of the word will help the reader solve the riddle. Students will work independently, as well as with their peers, in order gain a better understanding of multiple meaning words and how to identify their correct meanings using reference materials and context clues.

2013-01-28

110

Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method  

SciTech Connect

Hepatic elimination of epidermal growth factor (EGF) via receptor-mediated endocytosis was studied by a multiple-indicator dilution method in the isolated perfused rat liver, in which cell polarity and spatial organization are maintained. In this method EGF was given with inulin, an extracellular reference, as a bolus into the portal vein, and dilution curves of both compounds in the hepatic vein effluent were analyzed. Analysis of the dilution curve for EGF, compared with that for somatostatin, which showed no specific binding to isolated liver plasma membranes, resulted as follows: (i) both extraction ratio and distribution volume of {sup 125}I-labeled EGF decreased as the injected amount of unlabeled EGF increased; (ii) the ratio plot of the dilution curve for EGF exhibited an upward straight line initially for a short period of time, whereas the ratio plot of somatostatin gradually decreased. The multiple-indicator dilution method was used for other peptides also. Insulin and glucagon, known to have hepatocyte receptors, behaved similarly to EGF in shape of their ratio plots. The kinetic parameters calculated by this analysis were comparable with reported values obtained by in vitro direct binding measurements at equilibrium using liver homogenates. They conclude that the multiple-indicator dilution method is a good tool for analyzing the dynamics of peptide hormones-cell-surface receptor interaction under a condition in which spatial architecture of the liver is maintained.

Sato, H.; Sugiyama, Y.; Sawada, Y.; Iga, T.; Sakamoto, S.; Fuwa, T.; Hanano, M. (Univ. of Tokyo (Japan))

1988-11-01

111

Multiple sort flow cytometer  

DOEpatents

A flow cytometer utilizes multiple lasers for excitation and respective fluorescence of identified dyes bonded to specific cells or events to identify and verify multiple events to be sorted from a sheath flow and droplet stream. Once identified, verified and timed in the sheath flow, each event is independently tagged upon separation from the flow by an electrical charge of +60, +120, or +180 volts and passed through oppositely charged deflection plates with ground planes to yield a focused six way deflection of at least six events in a narrow plane.

Van den Engh, Ger (Seattle, WA); Esposito, Richard J. (Seattle, WA)

1996-01-01

112

Multiple sort flow cytometer  

DOEpatents

A flow cytometer utilizes multiple lasers for excitation and respective fluorescence of identified dyes bonded to specific cells or events to identify and verify multiple events to be sorted from a sheath flow and droplet stream. Once identified, verified and timed in the sheath flow, each event is independently tagged upon separation from the flow by an electrical charge of +60, +120, or +180 volts and passed through oppositely charged deflection plates with ground planes to yield a focused six way deflection of at least six events in a narrow plane. 8 figs.

Engh, G. van den; Esposito, R.J.

1996-01-09

113

Factor-multiple Chains  

NSDL National Science Digital Library

This problem offers opportunities for students to reinforce their understanding of factors and multiples and provides them the chance to justify their solutions. The goal is for the students to create number chains of four whole numbers that can range from 2 to 100 and each consecutive number is a multiple of the previous number. The Teachers' Notes page offers suggestions for implementation, key discussion questions, ideas for extension and support, and a link to a spreadsheet for students to experiment with placing numbers in specific boxes in the chain.

2007-04-01

114

Multiple Rankine topping cycles  

SciTech Connect

The efficiency of a Rankine cycle is primarily determined by the temperatures of heat addition and rejection. However, no working fluid has been identified which will operate in a Rankine cycle over an extremely wide temperature range. Multiple Rankine topping cycles offer a technique for achieving high thermal efficiencies in power plants by allowing the use of several working fluids. This paper gives a history of Rankine topping cycles, presents an analysis for the calculation of the overall efficiency of a three-module multiple Rankine cycle, and presents results from a case study for a sodium-mercury-water cycle.

McWhirter, J.D. [Argonne National Lab., Idaho Falls, ID (United States). Engineering Div.]|[Idaho State Univ., Pocatello, ID (United States). Coll. of Engineering

1995-07-01

115

Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma.  

PubMed

L-type amino-acid transporter 1 (LAT1) plays a key role in cell growth and survival. To determine the prognostic significance of LAT1 in multiple myeloma (MM), we investigated the expression of LAT1 and its functional subunit, 4Fc heavy chain (CD98), on myeloma cells by immunohistochemistry in 100 newly diagnosed MM patients. High expression (moderate or strong staining intensity) of LAT1 and CD98 was detected in 56% and 45% of patients, respectively. The LAT1 expression score was positively correlated with Ki-67 index (r = 0.631, P < 0.001), and there was a statistically significant difference in Durie-Salmon stage between patients with high and low LAT1 expression (P = 0.03). In 43 patients treated with melphalan and prednisolone, the overall response rate was significantly higher in the high LAT1 expression group (60.0%) than in the low LAT1 expression group (17.6%) (P = 0.03). Multivariate analysis confirmed that high expression of LAT1 was a significant prognostic factor for predicting poor overall survival independently from the International Staging System (both P = 0.01). Here, we show that the overexpression of LAT1 is significantly associated with high proliferation and poor prognosis in newly diagnosed MM patients. Thus, LAT1 may be a promising pathological marker for identifying high-risk MM. PMID:25220100

Isoda, Atsushi; Kaira, Kyoichi; Iwashina, Masanori; Oriuchi, Noboru; Tominaga, Hideyuki; Nagamori, Shushi; Kanai, Yoshikatsu; Oyama, Tetsunari; Asao, Takayuki; Matsumoto, Morio; Sawamura, Morio

2014-11-01

116

Indices of cognitive dysfunction in relapsing-remitting multiple sclerosis: intra-individual variability, processing speed, and attention network efficiency.  

PubMed

Impairments in attention and information processing speed are common in multiple sclerosis (MS) and may contribute to impairments of other cognitive abilities. This study examined attentional efficiency, information processing speed and intra-individual variability in response speed using the Attention Network Test-Interactions (ANT-I) in mildy-affected patients with MS. Thirty-one patients with relapsing-remitting MS and 30 age, sex, and education-matched controls completed the ANT-I, as well as the Paced Auditory Serial Attention Test (PASAT), as a standard clinical measure of information processing efficiency. As expected, patients with MS were slower in reaction time performance on the ANT-I and had poorer performance on the PASAT compared to controls. Patients with MS also demonstrated poorer efficiency in their executive control of attention on the ANT-I, suggesting difficulties with top-down allocation of attention. In addition, the MS group demonstrated greater intra-individual variability in the responses to the ANT-I even when their slower overall response time and other factors such as practice were accounted for. Intra-individual variability was found to best predict group membership compared to PASAT scores and other ANT-I scores. These results suggest that intra-individual variability may provide sensitive, unique and important information regarding cognitive functioning in early MS. PMID:23425598

Wojtowicz, Magdalena; Omisade, Antonina; Fisk, John D

2013-05-01

117

Dimensions of Multiple Personality Disorder  

Microsoft Academic Search

Research on multiple personality disorder (MPD) has burgeoned, and large-scale investigations indicate that a typical MPD patient is a woman, a victim of childhood abuse (especially sexual abuse), a person whose symptoms meet criteria for other psychiatric disorders, and a person who would employ many psychological defenses. Treatment approaches have frequently included hypnotherapy, which requires skill and caution.

John B. Murray

1994-01-01

118

IMMUNOLOGY OF MULTIPLE SCLEROSIS  

Microsoft Academic Search

Ke yW ords autoimmunity, autoimmune mechanisms, neuroimmunology, demyelinating dieseases, EAE ? Abstract Multiple sclerosis (MS) develops in young adults with a complex pre- disposing genetic trait and probably requires an inciting environmental insult such as a viral infection to trigger the disease. The activation of CD4+ autoreactive T cells and their differentiation into a Th1 phenotype is a crucial event

Mireia Sospedra; Roland Martin

2005-01-01

119

Automatic multiple applicator electrophoresis  

NASA Technical Reports Server (NTRS)

Easy-to-use, economical device permits electrophoresis on all known supporting media. System includes automatic multiple-sample applicator, sample holder, and electrophoresis apparatus. System has potential applicability to fields of taxonomy, immunology, and genetics. Apparatus is also used for electrofocusing.

Grunbaum, B. W.

1977-01-01

120

Nutrition and multiple gestation.  

PubMed

Multiple pregnancy represents a state of magnified nutritional requirements, resulting in a greater nutrient drain on maternal resources and an accelerated depletion of nutritional reserves. The accelerated starvation which occurs in pregnancy is exaggerated with a multiple gestation, particularly during the second half of pregnancy, with more rapid depletion of glycogen stores and resultant metabolism of fat between meals and during an overnight fast. A reduced glucose stream from mother to fetus results in slower fetal growth, smaller birth size, as well as a higher risk of preterm labor and preterm birth. For this reason, diet therapy with a diabetic regimen of 20% of calories from protein, 40% of calories from carbohydrate, and 40% of calories from fat may be particularly useful. Iron-deficiency anemia has also been linked to preterm delivery and other adverse pregnancy outcomes. Mobilization of maternal iron stores, in addition to an adequate amount and pattern of gestational weight gain (including BMI-specific weight gain goals by 20 and 28 weeks gestation), has been associated with significantly better fetal growth and longer gestations in twin pregnancies. Supplementation with calcium, magnesium, and zinc, as well as multivitamins and essential fatty acids may also reduce pregnancy complications and improve postnatal health for infants born from a multiple gestation. Diet therapy for women pregnant with multiples is an important component of effective prenatal care. PMID:16360494

Luke, Barbara

2005-10-01

121

Simplifying Algebraic Expressions: Multiplication  

NSDL National Science Digital Library

This learning object from Wisc-Online covers simplifying algebraic expressions using multiplication. The unit's activities include defining the terminology associated with algebraic operations, using the fundamental laws of algebra to simplify those expressions, removing the symbols of grouping and changing the signs of the appropriate terms to simplify expressions. Practice questions are also included.

Blohowiak, Chad; Jensen, Douglas; Reed, Allen

2011-02-01

122

Reasoning About Multiplication & Division  

NSDL National Science Digital Library

This 7-minute video features Drew Crandall working with his third grade class to develop concepts involving properties of operations and the relationship between multiplication and division. His approach allows students to learn from each other, to construct and revise their own meaning, and to develop communication skills. A downloadable transcript of the video is available (doc).

2013-01-01

123

Multiple Grammars and MOGUL  

ERIC Educational Resources Information Center

Optionality is a central phenomenon in second language acquisition (SLA), for which any adequate theory must account. Amaral and Roeper (this issue; henceforth A&R) offer an appealing approach to it, using Roeper's Multiple Grammars Theory, which was created with first language in mind but which extends very naturally to SLA. They include…

Truscott, John

2014-01-01

124

?Teriflunomide for multiple sclerosis.  

PubMed

?Teriflunomide (Aubagio-Genzyme Therapeutics), the main metabolite of the disease-modifying anti-rheumatic drug leflunomide,1 is an immunomodulatory agent with anti-inflammatory properties.2 It is a new oral treatment licensed for adults with relapsing-remitting multiple sclerosis. Here we discuss the evidence for its effectiveness and safety, and consider its place in therapy. PMID:25012149

2014-07-01

125

Multiple Penile Schwannomas  

PubMed Central

The occurrence of penile schwannoma is very rare. A 41-year-old man presented with multiple penile tumors and pain on erection. The largest tumor causing pain was excised. Pathology was characteristic of benign schwannoma. We recommend that penile schwannomas be excised if the tumors cause pain or are malignant. PMID:17406168

Liu, Wayne Young; Chao-Hsiang, Chang; Tseng, Gaun-Chin

2006-01-01

126

Multiple Intelligences: A Collection.  

ERIC Educational Resources Information Center

As a concise resource for Howard Gardner's theory of multiple intelligences and its implications for schooling around the world, this collection is designed for educators, parents, and others interested in education. The first section discusses Gardner and his background, and the second section expounds his theory. The third section explores the…

Fogarty, Robin, Ed.; Bellanca, James, Ed.

127

Multiple DNB events  

Microsoft Academic Search

The phenomenon of multiple DNB events in rod bundle heat transfer tests, referring to the occurrence of departure from nucleate boiling (DNB) on more than one heating rod or at more than one location on one heating rod, is examined. This phenomenon is characterized by the deterioration of heat transfer due to the transition from nucleate boiling to film boiling

A. N. Nahavandi; C. F. Fighetti; D. G. Reddy; T. C. L. Poon

1981-01-01

128

What about multiple intelligence?  

Microsoft Academic Search

Gardner (1983) produced a multiple intelligence theory to question the previous generalised measurements for intelligence. He challenged these earlier theories of intelligence by producing a theory in which a group of intelligences could be identified in order to be more specific in the assessment of an individual's ability. Gardner proposed the following intelligences: verbal; mathematical; musical accomplishment; spatially analysing the

Jack K. Garlovsky

129

Multiple Rankine topping cycles  

Microsoft Academic Search

The efficiency of a Rankine cycle is primarily determined by the temperatures of heat addition and rejection. However, no working fluid has been identified which will operate in a Rankine cycle over an extremely wide temperature range. Multiple Rankine topping cycles offer a technique for achieving high thermal efficiencies in power plants by allowing the use of several working fluids.

McWhirter

1995-01-01

130

Multiple Slit Diffraction Model  

NSDL National Science Digital Library

The EJS Multiple Slit Diffraction model allows the user to simulate Fraunhofer diffraction through single or multiple slits. The user can modify the number of slits, the slit width, the slit separation and the wavelength of the incident light. The scale of the diffraction pattern can also be changed and a plot of the light intensity can be toggled on and off with a checkbox. A basic theoretical introduction to diffraction is included. The Multiple Slit Diffraction Model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_ntnu_optics_MultipleSlitDiffraction.jar file will run the program if Java is installed. Ejs is a part of the Open Source Physics Project and is designed to make it easier to access, modify, and generate computer models. Additional Open Source Physics programs for quantum mechanics are available. They can be found by searching ComPADRE for Open Source Physics, OSP, or EJS.

Hwang, Fu-Kwun

2008-11-22

131

Multiple gene analyses of caligid copepods indicate that the reduction of a thoracic appendage in Pseudocaligus represents convergent evolution  

PubMed Central

Background The Caligidae is a family of parasitic copepods containing over 30 recognised genera. They are commercially important parasites as they cause disease in numerous finfish aquaculture facilities globally. Morphological features are used to distinguish between the genera and Pseudocaligus has traditionally been differentiated from Caligus solely by the presence of a much reduced form of the fourth thoracic leg. Currently there are numerous DNA sequences available for Caligus spp. but only the type species, Pseudocaligus brevipedis, has molecular data available, so systematic studies using molecular phylogenetic analyses have been limited. Methods Three gene regions, SSU rDNA, 16S and CO1, for Pseudocaligus fugu from puffer fish from Japan and Pseudocaligus uniartus from rabbit fish from Indonesia are sequenced and molecular phylogenetic analyses performed in order to infer phylogenetic relationships between Pseudocaligus and other caligid copepods. Results The analysis revealed that there was no discrete grouping of Pseudocaligus spp. and that they had a polyphyletic distribution within Caligus taxa. Pseudocaligus fugu grouped with Caligus elongatus and contained a unique synapomorphy in the SSU rDNA region only seen in members of that clade. Pseudocaligus uniartus formed a well-supported group, in the SSU rDNA analyses, with a Caligus sp. that also infects rabbit fish, but was unresolved in the other analyses. Pseudocaligus brevipedis consistently and robustly grouped with Caligus curtus and C. centrodonti in all analyses. The majority of Lepeophtheirus spp. form a monophyletic sister group to the Caligus clade; however, L. natalensis is unresolved in all analyses and does not form part of the main Lepeophtheirus clade. Conclusions These findings do not support the morphological-based distinction between Pseudocaligus and Caligus, suggesting that the reduced fourth leg is a feature that has evolved on multiple occasions throughout caligid evolution. Congruent molecular phylogenetic data support groupings based on the presence of morphological features, such as lunules, geography and host fish type rather than appendage morphology. Therefore, we support the synonymy of Pseudocaligus with Caligus. PMID:24286135

2013-01-01

132

Core Multiplication in Childhood  

PubMed Central

A dedicated, non-symbolic, system yielding imprecise representations of large quantities (Approximate Number System, or ANS) has been shown to support arithmetic calculations of addition and subtraction. In the present study, 5–7-year-old children without formal schooling in multiplication and division were given a task requiring a scalar transformation of large approximate numerosities, presented as arrays of objects. In different conditions, the required calculation was doubling, quadrupling, or increasing by a fractional factor (2.5). In all conditions, participants were able to represent the outcome of the transformation at above-chance levels, even on the earliest training trials. Their performance could not be explained by processes of repeated addition, and it showed the critical ratio signature of the ANS. These findings provide evidence for an untrained, intuitive process of calculating multiplicative numerical relationships, providing a further foundation for formal arithmetic instruction. PMID:20537618

McCrink, Koleen; Spelke, Elizabeth S.

2011-01-01

133

Fatigue in multiple sclerosis  

Microsoft Academic Search

Fatigue is among the most common, yet least understood, symptoms of multiple sclerosis (MS) [1·]. It can profoundly disrupt\\u000a the occupational and social functioning of patients, and is recognized as a criterion for MS disability by the Social Security\\u000a Administration. Most approaches to fatigue assessment can be classified as either self-report scales or performance-based\\u000a measures of motor or cognitive output.

Lauren B. Krupp; Christopher Christodoulou

2001-01-01

134

Multiple Miniature Avionic Displays  

NASA Technical Reports Server (NTRS)

A display screen for displaying multiple sets of information is provided. In one embodiment, an aviation display screen includes a main window and a plurality of miniature windows. The main window is adapted to illustrate one set of information. Each miniature window is adapted to display a set of avionic information. The avionic display is further adapted to toggle a select set of avionic information in one of the miniature windows into the main window.

Rye, Jeffrey M. (Inventor); Dorneich, Michael C. (Inventor); Gannon, Aaron J. (Inventor)

2008-01-01

135

Multiple Primary Cancer Monograph  

Cancer.gov

To identify groups of cancer survivors that are at increased risk for multiple primary cancers, Radiation Epidemiology Branch (REB) investigators led a collaborative effort to provide the first comprehensive population-based analysis of the risk of subsequent cancer in the U.S. The 500-page monograph utilized data from nine cancer registries participating in the Surveillance, Epidemiology, and End Results (SEER) Program from 1973 to 2000.

136

Universality of particle multiplicities  

SciTech Connect

We discuss the scaling properties and universality aspects of the rapidity and multiplicity distributions of particles produced in high energy hadronic and e{sup +}e{sup {minus}} interactions. This paper is based on material presented in three lectures on pomeron phenomenology, which included a review of traditional soft pomeron physics and selected topics on hard diffraction processes probing the structure function of the pomeron.

Goulianos, K. [Fermi National Accelerator Lab., Batavia, IL (United States)]|[Rockefeller Univ., New York, NY (United States)

1994-09-01

137

Multiple System Atrophy  

Microsoft Academic Search

Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder characterized clinically by various combinations of\\u000a parkinsonian, autonomic, cerebellar, or pyramidal symptoms and signs and pathologically by cell loss, gliosis, and glial cytoplasmic\\u000a inclusions in several brain and spinal cord structures. The term MSA was introduced in 1969, however cases of MSA were previously\\u000a reported under the rubrics of striatonigral degeneration,

Felix Geser; Gregor K. Wenning

138

Multiple Stressors and Disturbances  

Microsoft Academic Search

\\u000a Marine communities are increasingly affected by numerous stressors that act as agents of physical and biological disturbance\\u000a through a combination of natural and human-induced impacts. These include storms, sedimentation, temperature changes, pollution,\\u000a eutrophication, over-harvesting, damage to habitats, arrival of invasive species and climate change. Here I discuss how multiple\\u000a stressors alter assemblages on rocky reefs through direct impacts on organisms

David R. Schiel

139

Multiple Coin Toss Model  

NSDL National Science Digital Library

The Ejs Multiple Coin Toss model displays the result of the flipping of N coins. The result of each set of coin flips is shown by the image of the pennies on the screen and the complete results of the tossing experiment is shown on a graph of the cumulative probability of heads. The number of coins flipped, N, and change the "fairness" of the coin by setting the probability of a "heads" result, p, can be set via text boxes. You can modify this simulation if you have Ejs installed by right-clicking within the plot and selecting âOpen Ejs Modelâ from the pop-up menu item. Ejs Multiple Coin Toss model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_MultipleCoinToss.jar file will run the program if Java is installed. Ejs is a part of the Open Source Physics Project and is designed to make it easier to access, modify, and generate computer models. Additional Ejs models for classical mechanics are available. They can be found by searching ComPADRE for Open Source Physics, OSP, or Ejs.

Christian, Wolfgang; Belloni, Mario

2008-11-15

140

Multiple Identity Enactments and Multiple Personality Disorder: A Sociocognitive Perspective  

Microsoft Academic Search

People who enact multiple identities behave as if they possess 2 or more selves, each with its own characteristic moods, memories, and behavioral repertoire. Under different names, this phenomenon occurs in many cultures: in North American culture, it is frequently labeled multiple personality disorder (MPD). This article reviews experimental, cross-cultural, historical, and clinical findings concerning multiplicity and examines the implications

Nicholas P. Spanos

1994-01-01

141

Energy efficient multiple antenna communication  

E-print Network

We consider a multiple-input, multiple-output (MIMO) wideband Rayleigh block fading channel where the channel state is unknown at the transmitter and receiver and there is only an average input power constraint. We compute ...

Ray, Siddharth, 1979-

2006-01-01

142

Using a summary measure for multiple quality indicators in primary care: the Summary QUality InDex (SQUID)  

Microsoft Academic Search

BACKGROUND: Assessing the quality of primary care is becoming a priority in national healthcare agendas. Audit and feedback on healthcare quality performance indicators can help improve the quality of care provided. In some instances, fewer numbers of more comprehensive indicators may be preferable. This paper describes the use of the Summary Quality Index (SQUID) in tracking quality of care among

Paul J Nietert; Andrea M Wessell; Ruth G Jenkins; Chris Feifer; Lynne S Nemeth; Steven M Ornstein

2007-01-01

143

Responsiveness of Great Lakes Wetland Indicators to Human Disturbances at Multiple Spatial Scales: A Multi-Assemblage Assessment  

Microsoft Academic Search

Developing indicators of ecosystem condition is a priority in the Great Lakes, but little is known about appropriate spatial scales to characterize disturbance or response for most indicators. We surveyed birds, fish, amphibians, aquatic macroinvertebrates, wetland vegetation, and diatoms at 276 coastal wetland locations throughout the U.S. Great Lakes coastal region during 2002–2004. We assessed the responsiveness of 66 candidate

John C. Brazner; Nicolas P. Danz; Anett S. Trebitz; Gerald J. Niemi; Ronald R. Regal; Tom Hollenhorst; George E. Host; Euan D. Reavie; Terry N. Brown; JoAnn M. Hanowski; Carol A. Johnston; Lucinda B. Johnson; Robert W. Howe; Jan J. H. Ciborowski

2007-01-01

144

EVALUATING THE EFFECTIVENESS OF GREAT LAKES COASTAL WETLAND INDICATORS USING MULTIPLE TAXONOMIC GROUPS: GEOGRAPHIC AND GEOMORPHIC INFLUENCES  

EPA Science Inventory

This work arises from a MED collaboration with the GLEI consortium funded by and EPA Star Grant. Results confirm that developing effective indicators for Great Lakes coastal wetlands requires determination of the geographic range and ecosystem type where indicators are appropriat...

145

Multiplicity of Solutions in Aerodynamics  

NASA Technical Reports Server (NTRS)

One of the most striking phenomena which accompany the flow of fluids such as air and water about bodies, is that of changes in character. This phenomena is still very little understood. We will first discuss the nature of these changes and then show that pure theory leads to a multiplicity of characters of flow, among which we will endeavor to indicate those bearing some analogy to experimental results.

Dupont, M

1927-01-01

146

Genetic Amniocentesis in Multiple Pregnancy  

Microsoft Academic Search

Objectives: Second-trimester genetic amniocentesis is the most frequently used invasive prenatal diagnostic technique. Several reports have been published about the effect of genetic amniocentesis on fetal loss in multiple pregnancies over the past two decades. Here we analyze our experience with genetic amniocentesis in multiple pregnancies over the past 10 years. Methods: Details of 184 multiple pregnancies were processed in

Csaba Papp; Artúr Beke; Zoltán Bán; Zoltán Papp

2004-01-01

147

Arabidopsis Transcriptome Profiling Indicates That Multiple Regulatory Pathways Are Activated during Cold Acclimation in Addition to the CBF Cold Response PathwayW?  

PubMed Central

Many plants, including Arabidopsis, increase in freezing tolerance in response to low, nonfreezing temperatures, a phenomenon known as cold acclimation. Previous studies established that cold acclimation involves rapid expression of the CBF transcriptional activators (also known as DREB1 proteins) in response to low temperature followed by induction of the CBF regulon (CBF-targeted genes), which contributes to an increase in freezing tolerance. Here, we present the results of transcriptome-profiling experiments indicating the existence of multiple low-temperature regulatory pathways in addition to the CBF cold response pathway. The transcript levels of ?8000 genes were determined at multiple times after plants were transferred from warm to cold temperature and in warm-grown plants that constitutively expressed CBF1, CBF2, or CBF3. A total of 306 genes were identified as being cold responsive, with transcripts for 218 genes increasing and those for 88 genes decreasing threefold or more at one or more time points during the 7-day experiment. These results indicate that extensive downregulation of gene expression occurs during cold acclimation. Of the cold-responsive genes, 48 encode known or putative transcription factors. Two of these, RAP2.1 and RAP2.6, were activated by CBF expression and thus presumably control subregulons of the CBF regulon. Transcriptome comparisons indicated that only 12% of the cold-responsive genes are certain members of the CBF regulon. Moreover, at least 28% of the cold-responsive genes were not regulated by the CBF transcription factors, including 15 encoding known or putative transcription factors, indicating that these cold-responsive genes are members of different low-temperature regulons. Significantly, CBF expression at warm temperatures repressed the expression of eight genes that also were downregulated by low temperature, indicating that in addition to gene induction, gene repression is likely to play an integral role in cold acclimation. PMID:12172015

Fowler, Sarah; Thomashow, Michael F.

2002-01-01

148

Multiple Cystic Lung Disease  

PubMed Central

A lung cyst is an air-filled lucent structure surrounded by a thin wall. The presence of multiple intrapulmonary cysts is defined as cystic lung disease. Although cystic lung disease is rare, incidental detection has increased significantly in recent years by screening using computed tomography. There are many conditions that can mimic lung cysts and cause cystic lung disease. Clinical, radiographic, and histologic findings are all necessary for a proper diagnosis, and multidisciplinary approaches are frequently required. The aim of this report is to review the causes and characteristics of cystic lung disease to better understand and improve treatment. PMID:23579924

Yoo, Chul-Gyu

2013-01-01

149

[Spasticity in multiple sclerosis].  

PubMed

Already in 1860, the great neurologist Charcot described the symptom spasticity in patients affected by "sclerose en plaque". Spasticity is one of the most common symptoms of multiple sclerosis MS). The consequences of spasticity are very disadvantages because it hinders the functional mobility and overburden disability. Moreover, in the later stages of MS spasticity may be complicated by seating problems, pressure sores, fibrous contractures and poor perineal hygiene. In this article, the therapeutical management of MS spasticity, in all its components (pharmacological, rehabilitative, surgical) is reviewed. PMID:15354762

Pappalardo, A; Patti, F; Reggio, A; Guglielmino, A; Mangiameli, S

2004-04-01

150

Immunology of multiple sclerosis  

Microsoft Academic Search

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) leading to demyelination, axonal damage,\\u000a and progressive neurologic disability. The development of MS is influenced by environmental factors, particularly the Epstein-Barr\\u000a virus (EBV), and genetic factors, which include specific HLA types, particularly DRB1*1501-DQA1*0102-DQB1*0602, and a predisposition\\u000a to autoimmunity in general. MS patients have increased circulating T-cell and

Michael P. Pender; Judith M. Greer

2007-01-01

151

Multiplication Tables - Matching Cards  

NSDL National Science Digital Library

This interactive Flash version of the familiar Concentration game ("pelmanism" in the UK) helps a single user practice multiplication facts while developing memory and concentration skills. The player can choose an array of 16, 20, or 24 cards, which appear face down. The goal is to flip two cards at a time to match all the pairs of factors with their products as efficiently as possible. A scoring feature discourages random guessing. Users can choose to work with factors in three ranges: 2x-10x, 2x-21x, or 11x-21x. Printable versions of the game cards are available to download.

2001-03-01

152

Multiple apocrine hidrocystomas.  

PubMed

A 83-year-old woman presented with a 7-year history of translucent papules that were scattered diffusely over her nose, peri-orbital region, and cheeks. These lesions were exacerbated by heat and exercise. Histopathologic examination of a biopsy specimen from the cheek showed a thin-walled cyst lined by a flattened bi-layered epithelium that exhibited decapitation secretion in the upper part of the epidermis. A diagnosis of multiple apocrine hidrocystomas was made based on the clinical and histopathologic findings, and the patient is currently considering treatment options. These include electrodesiccation, excision, trichloracetic acid, carbon-dioxide laser, and 1450-nm diode laser. PMID:18627748

Anandasabapathy, Niroshana; Soldano, Anthony C

2008-01-01

153

In muscle lengthening surgery multiple aponeurotomy does not improve intended acute effects and may counter-indicate: an assessment by finite element modelling.  

PubMed

The goal was to assess the effects of multiple aponeurotomy on mechanics of muscle with extramuscular myofascial connections. Using finite element modelling, effects of combinations of the intervention carried out at a proximal (P), an intermediate (I) and a distal (D) location were studied: (1) Case P, (2) Case P-I, (3) Case P-D and (4) Case P-I-D. Compared to Case P, the effects of multiple interventions on muscle geometry and sarcomere lengths were sizable for the distal population of muscle fibres: e.g. at high muscle length (1) summed gap lengths between the cut ends of aponeurosis increased by 16, 25 and 27% for Cases P-I, P-D and P-I-D, respectively, (2) characteristic substantial sarcomere shortening became more pronounced (mean shortening was 26, 29, 30 and 31% for Cases P, P-I, P-D and P-I-D, respectively) and (3) fibre stresses decreased (mean stress equalled 0.49, 0.39, 0.38 and 0.33 for Cases P, P-I, P-D and P-I-D, respectively). In contrast, no appreciable effects were shown for the proximal population. The overall change in sarcomere length heterogeneity was limited. Consequently, the effects of multiple aponeurotomy on muscle length-force characteristics were marginal: (1) a limited reduction in active muscle force (maximal 'muscle weakening effect' remained between 5 and 11%) and (2) an even less pronounced change in slack to optimum length range of force exertion (maximal 'muscle lengthening effect' distally was 0.2% for Case P-I-D) were shown. The intended effects of the intervention were dominated by the one intervention carried out closer to the tendon suggesting that aponeurotomies done additionally to that may counter-indicated. PMID:21806415

Yucesoy, Can A; Seref-Ferlengez, Zeynep; Huijing, Peter A

2013-01-01

154

Multiple capillary biochemical analyzer  

DOEpatents

A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being analyzed, using a modified sheath flow cuvette. A linear or rectangular array of capillaries is introduced into a rectangular flow chamber. Sheath fluid draws individual sample streams through the cuvette. The capillaries are closely and evenly spaced and held by a transparent retainer in a fixed position in relation to an optical detection system. Collimated sample excitation radiation is applied simultaneously across the ends of the capillaries in the retainer. Light emitted from the excited sample is detected by the optical detection system. The retainer is provided by a transparent chamber having inward slanting end walls. The capillaries are wedged into the chamber. One sideways dimension of the chamber is equal to the diameter of the capillaries and one end to end dimension varies from, at the top of the chamber, slightly greater than the sum of the diameters of the capillaries to, at the bottom of the chamber, slightly smaller than the sum of the diameters of the capillaries. The optical system utilizes optic fibres to deliver light to individual photodetectors, one for each capillary tube. A filter or wavelength division demultiplexer may be used for isolating fluorescence at particular bands.

Dovichi, Norman J. (Edmonton, CA); Zhang, Jian Z. (Edmonton, CA)

1995-01-01

155

Phylogeographical analysis of mtDNA data indicates postglacial expansion from multiple glacial refugia in woodland caribou (Rangifer tarandus caribou).  

PubMed

Glacial refugia considerably shaped the phylogeographical structure of species and may influence intra-specific morphological, genetic, and adaptive differentiation. However, the impact of the Quaternary ice ages on the phylogeographical structure of North American temperate mammalian species is not well-studied. Here, we surveyed ~1600 individuals of the widely distributed woodland caribou (Rangifer tarandus caribou) using mtDNA control region sequences to investigate if glacial refugia contributed to the phylogeographical structure in this subspecies. Phylogenetic tree reconstruction, a median-joining network, and mismatch distributions supported postglacial expansions of woodland caribou from three glacial refugia dating back to 13544-22005 years. These three lineages consisted almost exclusively of woodland caribou mtDNA haplotypes, indicating that phylogeographical structure was mainly shaped by postglacial expansions. The putative centres of these lineages are geographically separated; indicating disconnected glacial refugia in the Rocky Mountains, east of the Mississippi, and the Appalachian Mountains. This is in congruence with the fossil record that caribou were distributed in these areas during the Pleistocene. Our results suggest that the last glacial maximum substantially shaped the phylogeographical structure of this large mammalian North American species that will be affected by climatic change. Therefore, the presented results will be essential for future conservation planning in woodland caribou. PMID:23285137

Klütsch, Cornelya F C; Manseau, Micheline; Wilson, Paul J

2012-01-01

156

Phylogeographical Analysis of mtDNA Data Indicates Postglacial Expansion from Multiple Glacial Refugia in Woodland Caribou (Rangifer tarandus caribou)  

PubMed Central

Glacial refugia considerably shaped the phylogeographical structure of species and may influence intra-specific morphological, genetic, and adaptive differentiation. However, the impact of the Quaternary ice ages on the phylogeographical structure of North American temperate mammalian species is not well-studied. Here, we surveyed ?1600 individuals of the widely distributed woodland caribou (Rangifer tarandus caribou) using mtDNA control region sequences to investigate if glacial refugia contributed to the phylogeographical structure in this subspecies. Phylogenetic tree reconstruction, a median-joining network, and mismatch distributions supported postglacial expansions of woodland caribou from three glacial refugia dating back to 13544–22005 years. These three lineages consisted almost exclusively of woodland caribou mtDNA haplotypes, indicating that phylogeographical structure was mainly shaped by postglacial expansions. The putative centres of these lineages are geographically separated; indicating disconnected glacial refugia in the Rocky Mountains, east of the Mississippi, and the Appalachian Mountains. This is in congruence with the fossil record that caribou were distributed in these areas during the Pleistocene. Our results suggest that the last glacial maximum substantially shaped the phylogeographical structure of this large mammalian North American species that will be affected by climatic change. Therefore, the presented results will be essential for future conservation planning in woodland caribou. PMID:23285137

Klütsch, Cornelya F. C.; Manseau, Micheline; Wilson, Paul J.

2012-01-01

157

Bayes multiple decision functions.  

PubMed

This paper deals with the problem of simultaneously making many (M) binary decisions based on one realization of a random data matrix X. M is typically large and X will usually have M rows associated with each of the M decisions to make, but for each row the data may be low dimensional. Such problems arise in many practical areas such as the biological and medical sciences, where the available dataset is from microarrays or other high-throughput technology and with the goal being to decide which among of many genes are relevant with respect to some phenotype of interest; in the engineering and reliability sciences; in astronomy; in education; and in business. A Bayesian decision-theoretic approach to this problem is implemented with the overall loss function being a cost-weighted linear combination of Type I and Type II loss functions. The class of loss functions considered allows for use of the false discovery rate (FDR), false nondiscovery rate (FNR), and missed discovery rate (MDR) in assessing the quality of decision. Through this Bayesian paradigm, the Bayes multiple decision function (BMDF) is derived and an efficient algorithm to obtain the optimal Bayes action is described. In contrast to many works in the literature where the rows of the matrix X are assumed to be stochastically independent, we allow a dependent data structure with the associations obtained through a class of frailty-induced Archimedean copulas. In particular, non-Gaussian dependent data structure, which is typical with failure-time data, can be entertained. The numerical implementation of the determination of the Bayes optimal action is facilitated through sequential Monte Carlo techniques. The theory developed could also be extended to the problem of multiple hypotheses testing, multiple classification and prediction, and high-dimensional variable selection. The proposed procedure is illustrated for the simple versus simple hypotheses setting and for the composite hypotheses setting through simulation studies. The procedure is also applied to a subset of a microarray data set from a colon cancer study. PMID:25414762

Wu, Wensong; Peña, Edsel A

2013-01-01

158

Evaluating the Spatial Distribution of Toxic Air Contaminants in Multiple Ecosystem Indicators in the Sierra Nevada-Southern Cascades  

NASA Astrophysics Data System (ADS)

Toxic air contaminants originating from agricultural areas of the Central Valley in California threaten vulnerable sensitive receptors including surface water, vegetation, snow, sediments, fish, and amphibians in the Sierra Nevada-Southern Cascades region. The spatial distribution of toxic air contaminants in different ecosystem indicators depends on variation in atmospheric concentrations and deposition, and variation in air toxics accumulation in ecosystems. The spatial distribution of organic air toxics and mercury at over 330 unique sampling locations and sample types over two decades (1990-2009) in the Sierra Nevada-Southern Cascades region were compiled and maps were developed to further understand spatial patterns and linkages between air toxics deposition and ecological effects. Potential ecosystem impacts in the Sierra Nevada-Southern Cascades region include bioaccumulation of air toxics in both aquatic and terrestrial ecosystems, reproductive disruption, and immune suppression. The most sensitive ecological end points in the region that are affected by bioaccumulation of toxic air contaminants are fish. Mercury was detected in all fish and approximately 6% exceeded human consumption thresholds. Organic air toxics were also detected in fish yielding variable spatial patterns. For amphibians, which are sensitive to pesticide exposure and potential immune suppression, increasing trends in current and historic use pesticides are observed from north to south across the region. In other indicators, such as vegetation, pesticide concentrations in lichen increase with increasing elevation. Current and historic use pesticides and mercury were also observed in snowpack at high elevations in the study area. This study shows spatial patterns in toxic air contaminants, evaluates associated risks to sensitive receptors, and identifies data gaps. Future research on atmospheric modeling and information on sources is needed in order to predict which ecosystems are the most sensitive to toxic air contaminants in the Sierra Nevada-Southern Cascades region.

Nanus, L.; Simonich, S. L.; Rocchio, J.; Flanagan, C.

2013-12-01

159

Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock.  

PubMed

Our recent evidence suggests that pancreatic digestive enzymes in the lumen of the intestine may play a major role in the production of cardiovascular stimulatory factors during splachnic artery occlusion and reperfusion. These stimulators are detected in plasma, but their origin and mechanism of production has remained uncertain. We examine here in the rat the role of pancreatic enzymes with and without administration of a serine protease inhibitor (FOY) into the lumen of the small intestine during splanchnic artery occlusion (90 min) and reperfusion (120 min). In the presence of pancreatic enzyme inhibition in the lumen of the intestine, there is significantly enhanced survival rate, lower levels of inflammatory mediator production, the femoral artery blood pressure is maintained close to control levels, and there are significantly lower levels of cell activators in plasma. These results support the hypothesis that pancreatic enzymes may escape across the brush border barrier during intestinal ischemia and thereby initiate the production of a powerful set of cytotoxic mediators. Blockade of pancreatic enzymes in the lumen of the intestine may be a tool to interfere with inflammation and early indicators of multiorgan failure. PMID:11900339

Mitsuoka, Hiroshi; Kistler, Erik B; Schmid-Schönbein, Geert W

2002-03-01

160

Multiple Differential Aperture Microscopy  

SciTech Connect

Differential-aperture X-ray microscopy (DAXM) is a powerful approach to 3D tomography with particular relevance to X-ray microdiffraction. With DAXM, scattering from submicron volumes can be resolved. However, the method is intrinsically a scanning technique where every resolved volume element (voxel) requires at least one area-detector readout. Previous applications of DAXM have used a single wire for knife-edge step profiling. Here, we demonstrate a way to accelerate DAXM measurements using multiple wires. A proof-of-principle experiment with a three-wire prototype showed that the speed of measurements can be tripled, but careful calibrations of wires will be required to maintain the spatial accuracy. In addition, related possibilities for accelerating measurements are briefly discussed.

Chung, Jin-Seok [ORNL; Isa, Saliman Anavami [ORNL; Greene, Virgil [ORNL; Broadwater, Ombreyan Q [ORNL; Liu, W. [Argonne National Laboratory (ANL); Ice, Gene E [ORNL

2007-01-01

161

Multiple layer insulation cover  

DOEpatents

A multiple layer insulation cover for preventing heat loss in, for example, a greenhouse, is disclosed. The cover is comprised of spaced layers of thin foil covered fabric separated from each other by air spaces. The spacing is accomplished by the inflation of spaced air bladders which are integrally formed in the cover and to which the layers of the cover are secured. The bladders are inflated after the cover has been deployed in its intended use to separate the layers of the foil material. The sizes of the material layers are selected to compensate for sagging across the width of the cover so that the desired spacing is uniformly maintained when the cover has been deployed. The bladders are deflated as the cover is stored thereby expediting the storage process and reducing the amount of storage space required.

Farrell, James J. (Livingston Manor, NY); Donohoe, Anthony J. (Ovid, NY)

1981-11-03

162

Pomalidomide for multiple myeloma.  

PubMed

Once characterized by a very poor outcome, multiple myeloma (MM) now has a significantly prolonged survival, with major improvements allowed by the use of 'novel agents': proteasome inhibitors (first-in-class bortezomib) and immunomodulatory compounds (IMiDs; first-in-class thalidomide and lenalidomide). However, the vast majority - if not all - of patients with MM ultimately end up being refractory to all existing drugs, including these efficient novel agents. There is a clear unmet medical need in this situation, which warrants the development of the next generation of proteasome inhibitors and IMiDs, as well as new drug classes. This drug profile focuses on pomalidomide, the next generation IMiD, recently approved by the US FDA and the EMA for patients with relapsed or refractory MM who have received at least two prior therapies, including lenalidomide and bortezomib, and have demonstrated disease progression on their last therapy. PMID:25265911

Fouquet, Guillemette; Bories, Claire; Guidez, Stéphanie; Renaud, Loïc; Herbaux, Charles; Javed, Sahir; Facon, Thierry; Leleu, Xavier

2014-12-01

163

Mixed Mode Matrix Multiplication  

SciTech Connect

In modern clustering environments where the memory hierarchy has many layers (distributed memory, shared memory layer, cache,...), an important question is how to fully utilize all available resources and identify the most dominant layer in certain computations. When combining algorithms on all layers together, what would be the best method to get the best performance out of all the resources we have? Mixed mode programming model that uses thread programming on the shared memory layer and message passing programming on the distributed memory layer is a method that many researchers are using to utilize the memory resources. In this paper, they take an algorithmic approach that uses matrix multiplication as a tool to show how cache algorithms affect the performance of both shared memory and distributed memory algorithms. They show that with good underlying cache algorithm, overall performance is stable. When underlying cache algorithm is bad, superlinear speedup may occur, and an increasing number of threads may also improve performance.

Meng-Shiou Wu; Srinivas Aluru; Ricky A. Kendall

2004-09-30

164

Multiplicative representations of integers  

Microsoft Academic Search

Lehh ? 2, and let ?=(B\\u000a 1, …,B\\u000a \\u000a h\\u000a ), whereB\\u000a \\u000a 1\\u000a ? N={1, 2, 3, …} fori=1, …,h. Denote by g?(n) the number of representations ofn in the formn=b\\u000a 1 …b\\u000a \\u000a h\\u000a , whereb\\u000a \\u000a i\\u000a ?B\\u000a \\u000a i\\u000a . If v (n) > 0 for alln >n\\u000a 0, then ? is anasymptotic multiplicative system of order h. The setB is

Melvyn B. Nathanson; ABSI RACI

1987-01-01

165

Dancing with Multiple Partners  

NSDL National Science Digital Library

Transmembrane proteins, such as G protein-coupled receptors (GPCRs) and integrins, activate intracellular signaling pathways through interactions with downstream binding partners. Woodside discusses two examples in which GPCRs and integrins interact in a noncompeting manner with more than one partner. The specific GPCR described is the thrombin receptor, in experiments where G protein peptides selectively block signaling through a particular G protein that does not appear to inhibit coupling of the receptor to other G proteins. The second system described is the ?IIb?3 integrin and its activation of the nonreceptor tyrosine kinase Syk. Syk appeared capable of interacting with both the integrin and intracellular domains of immune response receptors, because binding of Syk to the integrin was not inhibited by peptides based on the Syk binding site in immune response receptors. Thus, multiple, noncompeting binding partners add to the complexity of signal transduction outputs from a single receptor complex.

Darren G. Woodside (Texas Biotechnology Corporation; REV)

2002-03-19

166

MULTIPLE GALAXY COLLISIONS  

NASA Technical Reports Server (NTRS)

Here is a sampling of 15 ultraluminous infrared galaxies viewed by NASA's Hubble Space Telescope. Hubble's sharp vision reveals more complexity within these galaxies, which astronomers are interpreting as evidence of a multiple-galaxy pileup. These images, taken by the Wide Field and Planetary Camera 2, are part of a three-year study of 123 galaxies within 3 billion light-years of Earth. The study was conducted in 1996, 1997, and 1999. False colors were assigned to these photos to enhance fine details within these coalescing galaxies. Credits: NASA, Kirk Borne (Raytheon and NASA Goddard Space Flight Center, Greenbelt, Md.), Luis Colina (Instituto de Fisica de Cantabria, Spain), and Howard Bushouse and Ray Lucas (Space Telescope Science Institute, Baltimore, Md.)

2002-01-01

167

Multiple primary cutaneous plasmacytoma.  

PubMed

A 66-year-old Japanese man presented with a painless skin tumor in his left axillae which had been present for several years without receiving any medical treatment. The tumor enlarged and lesions appeared on several areas on his body within a few months of April 2012 (Fig. 1). Histopathological examination of a skin biopsy specimen taken from a right inguinal tumor showed a dense infiltrate of atypical plasmacytoid cells in the dermis and subcutis (Fig. 2). The epidermis and papillary dermis were not involved. Immunohistological analysis revealed that the tumor cells were negative for T- and B-cell surface markers CD3, CD4, CD8, CD20, CD56, CD79, and HLA-DR (Fig. 3), as well as the mature plasma cell and plasma neoplasm marker, CD138 (Fig. 3), but were positive for IgG, IgG ? light chain, bcl-2 and multiple myeloma oncogene-1 (MUM-1) (Fig. 4). Laboratory investigation revealed a small amount of Bence-Jones protein in the urine and elevated serum levels of total protein (10.5 g/dL), creatinine (1.4 mg/dL), calcium (1.4 mg/dL), immunoglobulin G (5720 mg/dL), and ?2 microglobulin (8.1 mg/dL). Chest and abdominal computed tomography showed multiple subcutaneous masses; however, other organs were unaffected. Histopathological examination of a bone marrow biopsy specimen showed no abnormalities. The diagnosis of primary cutaneous plasmacytoma (PCP) was made based on the International Myeloma Working Group criteria (1). The patient was treated with bortezomib and combined vincristine, doxorubicin, and dexamethasone therapy. The tumors initially responded to therapy by decreasing in size and temporarily disappearing. Several months later, the subcutaneous tumors reappeared and enlarged, and the patient subsequently died from bleeding from a tumor in the abdomen 14 months after initial presentation. Extramedullar plasmacytoma (EMP) is a plasma cell tumor that arises outside the bone marrow and may occur in the upper respiratory tract, gastrointestinal tract, and central nervous system, but cutaneous involvement is rare (1). PCPs constitute approximately 2-4% of EMP (2). A prognostic difference between the solitary and multiple forms of the disease has been highlighted by some clinicians who pointed out that the latter runs a more aggressive course and has a relatively high mortality rate, as was seen in our patient (3). PCP cells usually express CD79a, CD38, and CD138, but are negative for CD20 and leukocyte common antigen. Monotypic expression of IgG light chains is usually present (3). In our case, tests were negative for CD79 and CD138, but positive for MUM-1, bcl-2, and IgG light chain. Bcl-2 is member of a family of signaling molecules with proapoptotic and anti-apoptotic activities (4). Located in the mitochondrial membrane, bcl-2 prevents cell death by inhibiting adapter molecules involved in the activation of caspases in the intrinsic pathway. Overexpression of bcl-2 is found in most human tumor types, and is associated with prolonged tumor cell survival, an aggressive clinical course, drug resistance, and a decreased survival rate (5). Tumor expression of bcl-2 and the presence of multiple tumors in the present case were associated with a poor prognosis. PMID:25580795

Maejima, Hideki; Katsuoka, Kensei; Togano, Tomiteru

2014-12-01

168

Multiple asteroid rendezvous missions  

NASA Technical Reports Server (NTRS)

Asteroid missions, centered on multiple asteroid rendezvous missions to main belt asteroids, are discussed and the required solar electric propulsion for these missions as well as the current performance estimates are examined. A brief statistical analysis involving asteroid availability transfer requirements and propulsion system capabilities is given, leading to a prediction that 5 to 8 asteroids can be encountered with a single launch. Measurement techniques include visual imaging, radio tracking, magnetometry, and in the case of landers, seismometry. The spacecraft will be propelled by a solar electric system with a power level of 25 kW to 40 kW and tour possibilities for 13 different asteroids have been developed. Preliminary estimates of asteroid triaxiality are made to calculate the effect of close orbits.

Bender, D. F.; Friedlander, A. L.

1979-01-01

169

Multiple Sclerosis in Children  

PubMed Central

Multiple sclerosis (MS) is the most important immune-mediated demyelinated disease of human which is typically the disease of young adults. A total of 4% to 5% of MS population are pediatric. Pediatric MS is defined as the appearance of MS before the age of sixteen. About 80% of the pediatric cases and nearly all adolescent onset patients present with attacks typical to adult MS. Approximately 97% to 99% of the affected children have relapsing-remitting MS, while 85% to 95% of the adults experience such condition. MS in children is associated with more frequent and severe relapses. Treatment is the same as adults. We aimed to review the epidemiology, etiology, clinical manifestations, and treatment of MS in children. PMID:24665290

INALOO, Soroor; HAGHBIN, Saideh

2013-01-01

170

Stochastically ordered multiple regression  

PubMed Central

In various application areas, prior information is available about the direction of the effects of multiple predictors on the conditional response distribution. For example, in epidemiology studies of potentially adverse exposures and continuous health responses, one can typically assume a priori that increasing the level of an exposure does not lead to an improvement in the health response. Such an assumption can be formalized through a stochastic ordering assumption in each of the exposures, leading to a potentially large improvement in efficiency in nonparametric modeling of the conditional response distribution. This article proposes a Bayesian nonparametric approach to this problem based on characterizing the conditional response density as a Gaussian mixture, with the locations of the Gaussian means varying flexibly with predictors subject to minimal constraints to ensure stochastic ordering. Theoretical properties are considered and Markov chain Monte Carlo methods are developed for posterior computation. The methods are illustrated using simulation examples and a reproductive epidemiology application. PMID:20150656

Bornkamp, Björn; Ickstadt, Katja; Dunson, David

2010-01-01

171

Treatment of multiple sclerosis.  

PubMed

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, with highly variable clinical course that most typically exhibits a relapsing-remitting pattern. Neuroimaging, pathological findings and response to available therapies are also not uniform. It commonly affects young adults and is usually characterized in the early years by acute relapses followed by partial or complete remission; in later years progressive and irreversible disability develops. The clinical course of MS is defined as relapsing-remitting (RRMS), primary progressive (PPMS), progressive relapsing (PRMS) and secondary progressive (SPMS). The treatment of RRMS is based on the use of immunosuppressive and immune-modulating therapy. Immunosuppressive agents have been used in multiple sclerosis for decades. Intravenous methylprednisolone is currently the treatment of choice for the relapses. The currently approved treatments for MS are disease-modifying agents, which only reduce the attack rate and delay progression in some patients and are believed to be effective only for the inflammatory component of the disease. Immunomodulating and immunosuppressive treatments are directed against the inflammatory process and are only partially effective. In RRMS, positive effects on disease activity have slowed disability progression, but in PPMS the same degree of effect of immunotherapies on relapses and active MRI lesions had little or no effects on the progression of disability. This partial failure could be explained by mechanisms of axonal damage at least partially independent from acute or chronic inflammation. This suggests that there is a need for better use of available treatments and the necessity of alternative new therapeutic options to stop disease progression and improve recovery mechanisms. The practicing neurologist must understand the MS spectrum and evaluate patient-specific factors to determine the best strategy for therapy. PMID:19601814

Anlar, Omer

2009-06-01

172

Multiple tree-ring isotopes as environmental indicators of diffuse atmospheric pollution in a peri-urban area  

NASA Astrophysics Data System (ADS)

The combined analyses of tree-ring ?13C, ?18O, ?15N, 206Pb/207Pb, 206Pb/204Pb and 206Pb/208Pb isotope ratios of three red spruce specimens from the Tantaré ecological reserve located 40 km northwest of Québec City (Canada) were studied with the aim of reconstructing environmental conditions and unravel past air-quality changes of the 1880-2007 period. To separate the tree-ring ?18O and ?13C patterns induced by natural conditions from those generated by anthropogenic perturbations, a linear regression was applied between the most explicative meteorological parameters and the isotopic series for the period of low pollution (1880 to 1909). The model equations were then applied to the most recent part of the series (1910-2007) to verify if climatic conditions have remained the main driver of the tree-ring isotopic variations. The good fit between the modeled and measured ?18O series for the entire studied period suggests that the assimilation of oxygen by red spruce trees is not significantly affected by pollution stress near Québec City. However, the deviation between the measured and modeled ?13C values for the 1944-2007 period indicates that diffuse pollution affected carbon assimilation by the investigated trees. To independently validate if atmospheric pollution could have generated the deviation between the measured and the estimated ?13C values, a linear regression was applied between the portion of the residual ?13C values and atmospheric pollution (Canadian fossil fuel proxy from 1958 to 2000). The nice fit between the modeled ?13C values from the combination of the two regression analyses based on climate and emission proxy strongly supports the hypothesis that there is a natural and an anthropogenic portion in the ?13C variations of the studied specimens. The short-term variations of the red spruce ?15N series are correlated with the instrumentally measured amounts of provincial N emissions for the 1990 to 2006 period (longest measurements available). Additionally, the long-term decrease of the ?15N series after 1956 is linked to the low isotopic values of NOx emitted by car exhausts, as expressed by the provincial number of cars which reflect the amount of transport-related N deposition at the provincial scale. The 208Pb/206Pb and 204Pb/206Pb ratios as a function of 206Pb/207Pb of the 1880-1919 period reflect a mixture of natural lead from the mineral soil horizon and mainly anthropogenic lead from north-eastern American coal combustion. The lower Pb ratios of the 1920-1989 period correlate well with the introduction of leaded additives to gasoline characterized by lower ratios relative to coal combustion. Inferring the lead sources of the 1990-2008 period is not as straightforward because lead can potentially derive from three main sources: coal combustion, burnt recycled material and natural lead present in soils. Our results show the great potential of tree-ring stable isotopes to record pollution events in the context of peri-urban diffuse pollution, and to prolong the pollution history in regions where direct measurements of pollutants only covers a relatively short period.

Doucet, A.; Savard, M. M.; Bégin, C.; Ouarda, T. B.; Marion, J.

2010-12-01

173

Multiple neurilemomas. A case report.  

PubMed

Multiple neurilemomas in diverse locations of the body developed in a 53-year-old woman. The patient had multiple neurilemomas which occurred in the thoracic spine, lumbar spine, retroperitoneal sympathetic chain, sacral nerve root, femoral nerve, both sciatic nerves, radial nerve, and ulnar nerve without evidence of Von Recklinghausen's disease. This is the first well documented report on multiple neurilemomas with whole body distribution. PMID:9917714

Shin, K H; Moon, S H; Suh, J S; Jahng, J S

1998-12-01

174

Multiple Surveys of Students and Survey Fatigue  

ERIC Educational Resources Information Center

This chapter reviews the literature on survey fatigue and summarizes a research project that indicates that administering multiple surveys in one academic year can significantly suppress response rates in later surveys. (Contains 4 tables.)

Porter, Stephen R.; Whitcomb, Michael E.; Weitzer, William H.

2004-01-01

175

Disability in multiple sclerosis  

PubMed Central

Objective: To create a reference table of disability outcomes in multiple sclerosis (MS) that would enable patients to rank their disability relative to others' with similar disease duration and to develop a cost-effective research tool for comparing MS severity across patient populations and time periods. Methods: The North American Research Committee on Multiple Sclerosis (NARCOMS) Registry collects disability data from patients with MS on a validated, 9-point Patient-Determined Disease Steps (PDDS) scale. We compiled the Disability Expectancy Table, which displays cumulative frequencies of PDDS scores for each year of disease duration, from 0 to 45 years. We also tabulated disease duration–adjusted mean ranks of PDDS scores, referred to as Patient-derived MS Severity Scores (P-MSSS). Results: The cohort consisted of 27,918 NARCOMS enrollees, 72.7% of whom were female and 90.1% of whom were white. Mean age at symptom onset was 30.1 ± 10.1 years, and age at enrollment was 47.1 ± 11.0 years. The Disability Expectancy Table and P-MSSS afford a detailed overview of disability outcomes in a large MS cohort over a 45-year period. In the first year of disease, 15% of patients reported need of ambulatory aid, and 4% needed bilateral assistance or worse; after 45 years of disease, 76% of patients required ambulatory aid, and 52% bilateral assistance or worse. Proportion of patients who reported minimal or no interference in daily activities (PDDS ? 1) declined from 63% in the first year to 8% after 45 years of disease. Conclusion: The Disability Expectancy Table allows individual patients to determine how their disability ranks relative to NARCOMS enrollees with the same disease duration. P-MSSS may be used to compare disability across patient populations and to track disease progression in patient cohorts. P-MSSS does not require a formal neurologic examination and may therefore find wide applicability as a practical and cost-effective outcome measure in epidemiologic studies. PMID:23427319

Chamot, Eric; Salter, Amber R.; Cutter, Gary R.; Bacon, Tamar E.; Herbert, Joseph

2013-01-01

176

Multiple Indicators of Poor Diet Quality in Children and Adolescents with Type 1 Diabetes Are Associated with Higher Body Mass Index Percentile but not Glycemic Control  

PubMed Central

Background Diet is a cornerstone of type 1 diabetes treatment, and poor diet quality may affect glycemic control and other health outcomes. Yet diet quality in children and adolescents with type 1 diabetes remains understudied. Objective To evaluate multiple indicators of diet quality in children and adolescents with type 1 diabetes and their associations with hemoglobin A1c and body mass index percentile. Design In this cross-sectional study, participants completed 3-day diet records, and data were abstracted from participants’ medical records. Diet quality indicators included servings of fruit, vegetables, and whole grains; Healthy Eating Index-2005 (HEI-2005) score; Nutrient Rich Foods 9.3 score (NRF 9.3); and glycemic index. Participants/setting Children and adolescents with type 1 diabetes ?1 year, aged 8 to 18 years, were recruited at routine clinic visits. Of 291 families enrolled, 252 provided diet data. Statistical analyses Associations of diet quality indicators to HbA1c and body mass index percentile were examined using analysis of covariance and multiple linear regression. Results Participants demonstrated low adherence to dietary guidelines; mean HEI-2005 score was 53.4±11.0 (range = 26.7 to 81.2). Intake of fruit, vegetables, and whole grains was less than half the recommended amount. Almost half of the participants’ daily energy intake was derived from refined-grain products, desserts, chips, and sweetened beverages. Higher fruit (P=0.04) and whole-grain (P=0.03) intake were associated with lower HbA1c in unadjusted, but not adjusted analyses; vegetable intake, HEI-2005 score, NRF 9.3 score, and glycemic index were not associated with HbA1c. Higher fruit (P=0.01) and whole-grain (P=0.04) intake and NRF 9.3 score (P=0.02), but not other diet quality indicators, were associated with lower body mass index percentile in adjusted analyses. Conclusions Data demonstrate poor diet quality in youth with type 1 diabetes and provide support for the importance of diet quality for weight management. Future research on determinants of dietary intake and methods to promote improved diet quality would be useful to inform clinical care. PMID:23102173

Nansel, Tonja R.; Haynie, Denise L.; Lipsky, Leah M.; Laffel, Lori M. B.; Mehta, Sanjeev N.

2014-01-01

177

Holocene climate variability in the European Arctic reconstructed from multiple proxy indicators and sites simultaneously using Bayesian multi-scale smoothing (Invited)  

NASA Astrophysics Data System (ADS)

We report a method for reconstructing temperatures from proxy data based on Bayesian multi-scale smoothing. The main features of the method is that it makes possible a simultaneous utilization of multiple proxies and sites to achieve a regional ‘consensus’ reconstruction of temperature, it enables various types of uncertainties (e.g., chronology) to be taken into account, and that it also allows significant features to be detected from the emerging time series. Applying the method to multiple proxy data derived from lakes in Finnish Lapland suggests that, contrary to the conventional view, Holocene climate cooling in the North Atlantic region started already c. 8.5 kyr, and that climate since then was punctuated by several quasi-cyclical climate events, the forcing mechanisms of which are not yet fully understood. Our study suggests that inconsistencies in climate reconstructions between different proxy sources may be at least partly spurious; there is probably no single narrative that counts as the canonical version of Holocene climate change. Instead, there may exist many ’truths’ depending on the proxy and the resolution the data are gained and examined. We expect this method to be effective for generating, synthesizing and interpreting paleoclimate records. BSiZer interpretation of the multi-proxy temperature reconstruction over the Holocene for northern Fennoscandia. Significant upward (positive) slopes are indicated in red, downward (negative) ones in blue. In the grey areas, no conclusions about the significance (?=0.8) of the slopes can be drawn. Smoothing levels (log10 ?) are shown on the left.

Korhola, A.; Weckström, J.; Erästö, P.; Holmström, L.

2009-12-01

178

Multiple trellis coded modulation  

NASA Technical Reports Server (NTRS)

A technique for designing trellis codes to minimize bit error performance for a fading channel. The invention provides a criteria which may be used in the design of such codes which is significantly different from that used for average white Gaussian noise channels. The method of multiple trellis coded modulation of the present invention comprises the steps of: (a) coding b bits of input data into s intermediate outputs; (b) grouping said s intermediate outputs into k groups of s.sub.i intermediate outputs each where the summation of all s.sub.i,s is equal to s and k is equal to at least 2; (c) mapping each of said k groups of intermediate outputs into one of a plurality of symbols in accordance with a plurality of modulation schemes, one for each group such that the first group is mapped in accordance with a first modulation scheme and the second group is mapped in accordance with a second modulation scheme; and (d) outputting each of said symbols to provide k output symbols for each b bits of input data.

Simon, Marvin K. (Inventor); Divsalar, Dariush (Inventor)

1990-01-01

179

Visualizing Multiple Quantile Plots.  

PubMed

Multiple-quantile plots provide a powerful graphical method for comparing the distributions of two or more populations. This article develops a method of visualizing triple-quantile plots and their associated confidence tubes, thus extending the notion of a quantile-quantile (QQ) plot to three dimensions. More specifically, we consider three independent one-dimensional random samples with corresponding quantile functions Q 1, Q 2, and Q 3. The triple-quantile (QQQ) plot is then defined as the three-dimensional curve Q(p) = (Q 1(p), Q 2(p), Q 3(p)), where 0 < p < 1. The empirical likelihood method is used to derive simultaneous distribution-free confidence tubes for Q. We apply our method to an economic case study of strike durations and to an epidemiological study involving the comparison of cholesterol levels among three populations. These data as well as the Mathematica code for computation of the tubes are available in the online supplementary materials. PMID:24465124

Boon, Marko A A; Einmahl, John H J; McKeague, Ian W

2013-03-01

180

Apoptosis of Multiple Myeloma  

PubMed Central

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. MM cells localize to the bone marrow, where cell adhesion–mediated autocrine or paracrine activation of various cytokines, such as interleukin 6, insulin-like growth factor 1, and interferon ?, results in their accumulation mainly because of loss of critical apoptotic controls. Resistance to apoptosis, a genetically regulated cell death process, may play a critical role in both pathogenesis and resistance to treatment of MM. Abnormalities in regulation and execution of apoptosis can contribute to tumor initiation, progression, as well as to tumor resistance to various therapeutic agents. Apoptosis is executed via 2 main pathways that lead to activation of caspases: the death receptor (extrinsic) pathway and the mitochondrial (intrinsic) pathway. Ionizing radiation and chemotherapeutic agents act primarily through the intrinsic pathway, in which mitochondria play the central role. Various therapeutic modalities that are effective in MM modulate levels of the proapoptotic and antiapoptotic Bcl-2 family of proteins and of inhibitors of apoptosis, expression of which is primarily regulated by p53, nuclear factor ?B, and STAT (signal transducers and activators of transcription) factors. This review focuses on the key concepts and some of the most recent studies of signaling pathways regulated in MM and summarizes what is known about the clinical role of these pathways. PMID:15540896

Oancea, Marcela; Mani, Aruna; Hussein, Mohamad A; Almasan, Alexandru

2005-01-01

181

Immunopathogenesis of multiple sclerosis  

PubMed Central

Multiple sclerosis (MS) is a suspected autoimmune disease in which myelin-specific CD4+ and CD8+ T cells enter the central nervous system (CNS) and initiate an inflammatory response directed against myelin and other components of the CNS. Acute MS exacerbations are believed be the result of active inflammation, and progression of disability is generally believed to reflect accumulation of damage to the CNS, particularly axonal damage. Over the last several years, the pathophysiology of MS is being appreciated to be much more complex, and it appears that the development of the MS plaque involves a large number of cell populations, including CD8+ T lymphocytes, B cells, and Th17 cells (a population of helper T cells that secrete the inflammatory cytokine IL-17). The axonal transection and degeneration that is thought to represent the basis for progressive MS is now recognized to begin early in the disease process and to continue in the progressive forms of the disease. Molecules important for limiting aberrant neural connections in the CNS have been identified, which suppress axonal sprouting and regeneration of transected axons within the CNS. Pathways have also been identified that prevent remyelination of the MS lesion by oligodendrocyte precursors. Novel neuroimaging methodologies and potential biomarkers are being developed to monitor various aspects of the disease process in MS. As we identify the pathways responsible for the clinical phenomena of MS, we will be able to develop new therapeutic strategies for this disabling illness of young adults. PMID:20182567

Racke, Michael K.

2009-01-01

182

Sphingolipids in multiple sclerosis  

PubMed Central

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the CNS. Oligodendrocytes, the myelin forming cells of the central nervous system (CNS), are target cells in MS. Although the etiology of MS is poorly known, new insights suggest oligodendrocyte apoptosis as one of the critical events followed by glial activation and infiltration of lymphocytes and macrophages. A major breakthrough in delineation of the mechanism of cell death, perivascular cuffing and glial activation came from elucidation of the sphingolipid signal transduction pathway. The sphingolipid signal transduction pathway induces apoptosis, differentiation, proliferation, and growth arrest depending upon cell and receptor types, and downstream targets. Sphingomyelin, a major component of myelin membrane formed by mature oligodendrocytes, is abundant in the CNS and ceramide, its primary catabolic product released by activation of either neutral or acidic sphingomyelinase, serves as a potential lipid second messenger or mediator molecule modulating diverse cellular signaling pathways. Similarly, under certain conditions, sphingosine produced from ceramide by ceramidase is phosphorylated by sphingosine kinases to sphingosine-1 phosphate, another potent second messenger molecule. Both ceramide and sphingosine-1 phosphate regulate life and death of many cell types including brain cells and participate in pathogenic processes of MS. In this review, we have made an honest attempt to compile recent findings made by others and us relating to the role of sphingolipids in the disease process of MS. PMID:20607622

Jana, Arundhati; Pahan, Kalipada

2010-01-01

183

Multiple stage railgun  

DOEpatents

A multiple stage magnetic railgun accelerator (10) for accelerating a projectile (15) by movement of a plasma arc (13) along the rails (11,12). The railgun (10) is divided into a plurality of successive rail stages (10a-n) which are sequentially energized by separate energy sources (14a-n) as the projectile (15) moves through the bore (17) of the railgun (10). Propagation of energy from an energized rail stage back towards the breech end (29) of the railgun (10) can be prevented by connection of the energy sources (14a-n) to the rails (11,12) through isolation diodes (34a-n). Propagation of energy from an energized rail stage back towards the breech end of the railgun can also be prevented by dividing the rails (11,12) into electrically isolated rail sections (11a-n, 12a-n). In such case means (55a-n) are used to extinguish the arc at the end of each energized stage and a fuse (31) or laser device (61) is used to initiate a new plasma arc in the next energized rail stage.

Hawke, Ronald S. (Livermore, CA); Scudder, Jonathan K. (Pleasanton, CA); Aaland, Kristian (Livermore, CA)

1982-01-01

184

PET in Multiple Sclerosis.  

PubMed

PET is a powerful in vivo functional imaging tool for investigating healthy and diseased brain. It provides noninvasive quantification of selected biological targets that could help build understanding of complex central nervous system disorders such as multiple sclerosis (MS). To date, in MS, PET could only offer complementary support to MRI studies because MRI has still a profound role in monitoring the clinical course of MS. However, recent developments in PET imaging offer the potential to assess the MS brain in vivo in a way that MRI is limited. PET in MS could be used for the investigation of underlying pathophysiology of neuroinflammation, neuronal dysfunction, and demyelination, and remyelination. Quantitative measures of molecular targets with PET could also have future uses in clinical trials of drug development. However, the use of PET is still limited because of the high costs of cyclotrons and radiochemical laboratories. Once these limitations are bypassed alongside advances in research, PET could help in the clinical practice of MS by providing a useful imaging tool for the accurate diagnosis, monitoring of clinical progression, and planning of treatment. PMID:24561681

Niccolini, Flavia; Su, Paul; Politis, Marios

2015-01-01

185

Single versus multiple imputation for genotypic data.  

PubMed

Due to the growing need to combine data across multiple studies and to impute untyped markers based on a reference sample, several analytical tools for imputation and analysis of missing genotypes have been developed. Current imputation methods rely on single imputation, which ignores the variation in estimation due to imputation. An alternative to single imputation is multiple imputation. In this paper, we assess the variation in imputation by completing both single and multiple imputations of genotypic data using MACH, a commonly used hidden Markov model imputation method. Using data from the North American Rheumatoid Arthritis Consortium genome-wide study, the use of single and multiple imputation was assessed in four regions of chromosome 1 with varying levels of linkage disequilibrium and association signals. Two scenarios for missing genotypic data were assessed: imputation of untyped markers and combination of genotypic data from two studies. This limited study involving four regions indicates that, contrary to expectations, multiple imputations may not be necessary. PMID:20018064

Fridley, Brooke L; McDonnell, Shannon K; Rabe, Kari G; Tang, Rui; Biernacka, Joanna M; Sinnwell, Jason P; Rider, David N; Goode, Ellen L

2009-01-01

186

Multiple Intelligences Centers and Projects.  

ERIC Educational Resources Information Center

Based upon Gardner's theory of multiple intelligences, this book guides elementary school teachers through the process of using classroom learning centers and projects by providing choices for students. The guide is divided into two sections, providing the theoretical background and information on how to develop multiple intelligences learning…

Chapman, Carolyn; Freeman, Lynn

187

Bent Bonds and Multiple Bonds.  

ERIC Educational Resources Information Center

Considers carbon-carbon multiple bonds in terms of Pauling's bent bond model, which allows direct calculation of double and triple bonds from the length of a CC single bond. Lengths of these multiple bonds are estimated from direct measurements on "bent-bond" models constructed of plastic tubing and standard kits. (CS)

Robinson, Edward A.; Gillespie, Ronald J.

1980-01-01

188

Fourier transform multiple quantum NMR  

Microsoft Academic Search

The motivation for detecting multiple quantum transitions by a Fourier transform experiment is reviewed and an experimental approach to high resolution multiple quantum spectra in dipolar systems along with results on some protonated liquid crystal systems are described. A simple operator formalism for the essential features of the time development is presented and some applications in progress are discussed. A

G. Drobny; A. Pines; S. Sinton; D. Weitekamp; D. Wemmer

1978-01-01

189

Multiple phases of protien gels  

Microsoft Academic Search

A multiple phase transition was observed in gels made by covalently cross-linking proteins in either native or denatured state. The enzymatic activity of the gels prepared from native alpha-chymotrypsin was determined for each of the multiple phases. The reversibility of the swelling degrees and the enzymatic reaction rates upon phase transition suggests that the protein is at a free energy

Masahiko Annaka; Toyoichi Tanaka

1994-01-01

190

Symptomatic therapy in multiple sclerosis  

PubMed Central

Multiple sclerosis is the most common disabling neurological disease of young adults. The ability to impact the quality of life of patients with multiple sclerosis should not only incorporate therapies that are disease modifying, but should also include a course of action for the global multidisciplinary management focused on quality of life and functional capabilities. PMID:21694806

Frohman, Teresa C.; Castro, Wanda; Shah, Anjali; Courtney, Ardith; Ortstadt, Jeffrey; Davis, Scott L.; Logan, Diana; Abraham, Thomas; Abraham, Jaspreet; Remington, Gina; Treadaway, Katherine; Graves, Donna; Hart, John; Stuve, Olaf; Lemack, Gary; Greenberg, Benjamin; Frohman, Elliot M.

2011-01-01

191

Undecidability of Multiplicative Subexponential Logic  

E-print Network

Undecidability of Multiplicative Subexponential Logic Kaustuv Chaudhuri INRIA, France kaustuv.chaudhuri@inria.fr [Presented at LINEARITY 2014, July 13, 2014] Abstract Subexponential logic is a variant of linear logic show that classical propositional multiplicative linear logic extended with one unrestricted and two

Paris-Sud XI, Université de

192

Multiplicative processes in visual cognition  

NASA Astrophysics Data System (ADS)

The Central Limit Theorem (CLT) is certainly one of the most important results in the field of statistics. The simple fact that the addition of many random variables can generate the same probability curve, elucidated the underlying process for a broad spectrum of natural systems, ranging from the statistical distribution of human heights to the distribution of measurement errors, to mention a few. An extension of the CLT can be applied to multiplicative processes, where a given measure is the result of the product of many random variables. The statistical signature of these processes is rather ubiquitous, appearing in a diverse range of natural phenomena, including the distributions of incomes, body weights, rainfall, and fragment sizes in a rock crushing process. Here we corroborate results from previous studies which indicate the presence of multiplicative processes in a particular type of visual cognition task, namely, the visual search for hidden objects. Precisely, our results from eye-tracking experiments show that the distribution of fixation times during visual search obeys a log-normal pattern, while the fixational radii of gyration follow a power-law behavior.

Credidio, H. F.; Teixeira, E. N.; Reis, S. D. S.; Moreira, A. A.; Andrade, J. S.

2014-03-01

193

MULTIPLE ECH LAUNCHER CONTROL SYSTEM  

SciTech Connect

OAK-B135 The addition of new, high power gyrotrons to the heating and current drive arsenal at DIII-D, required a system upgrade for control of fully steerable ECH Launchers. Each launcher contains two pointing mirrors with two degrees of mechanical freedom. The two flavors of motion are called facet and tilt. Therefore up to four channels of motion per launcher need to be controlled. The system utilizes absolute encoders to indicate mirror position and therefore direction of the microwave beam. The launcher movement is primarily controlled by PLC, but future iterations of design, may require this control to be accomplished by a CPU on fast bus such as Compact PCI. This will be necessary to accomplish real time position control. Safety of equipment and personnel is of primary importance when controlling a system of moving parts. Therefore multiple interlocks and fault status enunciators have been implemented. This paper addresses the design of a Multiple ECH Launcher Control System, and characterizes the flexibility needed to upgrade to a real time position control system in the future.

GREEN,M.T; PONCE,D; GRUNLOH,H.J; ELLIS,R.A; GROSNICKLE,W.H; HUMPHREY,R.L

2003-10-01

194

Proton interactions with high multiplicity  

SciTech Connect

Project Thermalization is aimed to study the proton-proton interaction with high multiplicity of secondary particles. The region of high multiplicity is especially actual at present. We expect the manifestation of the secondary particle collective behavior at this region. The experimentally measured topological cross section was corrected for apparatus acceptance and detection efficiency. These data are in good agreement with gluon dominance model. The comparison with other models is also done and shows no essential deviations. There is evidence that Bose-Einstein condensation can formed at high total multiplicity region.

Kokoulina, E. S., E-mail: kokoulin@sunse.jinr.ru; Nikitin, V. A.; Petukhov, Y. P. [LHEP, JINR (Russian Federation); Kutov, A. Ya. [Department of Mathematics Komi SC UrD RAS (Russian Federation)

2012-06-15

195

Studies of porcine circovirus type 2, porcine boca-like virus and torque teno virus indicate the presence of multiple viral infections in postweaning multisystemic wasting syndrome pigs.  

PubMed

In a previous study, using random amplification and large-scale sequencing technology, we identified a novel porcine parvovirus belonging to the genus Bocavirus in the background of porcine circovirus type 2 (PCV-2) in Swedish pigs with postweaning multisystemic wasting syndrome (PMWS). In addition to bocavirus we demonstrated the presence of torque teno virus (TTV) genogroups 1 and 2 in these cases of PMWS, indicating the simultaneous presence of several viruses in this disease complex. In the present study, 34 PMWS-affected animals and 24 pigs without PMWS were screened by PCR for the presence of PCV-2, TTV-1, TTV-2 and porcine boca-like virus (Pbo-likeV). The studies revealed the following infection rates in the PMWS-affected pigs: PCV-2 100%, TTV-1 77%, TTV-2 94% and Pbo-likeV 88%. In comparison, the pigs without PMWS had the following rates: PCV-2 80%, TTV-1 79%, TTV-2 83% and Pbo-likeV 46%. The sequence identity between the different Swedish Pbo-likeV sequences ranged between 98% and 100%. By checking co-infection, it was found that 71% of the PMWS-affected pigs harbor simultaneously all these viruses. As a contrast, in the group without PMWS only 33% of the animals were positive simultaneously for these viruses. These observations indicate a multiple viral infection in PMWS-affected pigs. It has to be studied further if the clinical manifestation of PMWS might be due to synergistic effects of different viruses acting together. PMID:20542066

Blomström, Anne-Lie; Belák, Sándor; Fossum, Caroline; Fuxler, Lisbeth; Wallgren, Per; Berg, Mikael

2010-09-01

196

Multiple Sclerosis and Vitamin D  

MedlinePLUS

... vitamin D Andrew J. Solomon, MD WHAT IS VITAMIN D AND WHY IS IT IMPORTANT IN MS? ... e100 Neurology Andrew J. Solomon Multiple sclerosis and vitamin D This information is current as of October ...

197

MULTIPLE SCALES FOR SUSTAINABLE RESULTS  

EPA Science Inventory

This session will highlight recent research that incorporates the use of multiple scales and innovative environmental accounting to better inform decisions that affect sustainability, resilience, and vulnerability at all scales. Effective decision-making involves assessment at mu...

198

Lung Multiple Primary Rules Matrix  

Cancer.gov

Lung Multiple Primary Rules – Matrix C340-C349 (Excludes lymphoma and leukemia M9590 – 9989 and Kaposi sarcoma M9140) * Prepare one abstract. Use the histology coding rules to assign the appropriate histology code. ** Prepare two or more abstracts.

199

[Fingolimod treatment in multiple sclerosis].  

PubMed

Multiple sclerosis (MS), an inflammatory disorder of the central nervous system, is characterized by relapsing-remitting (RR) clinical course. Fingolimod was the first oral therapy to prevent relapses in patients with RRMS, approved in Japan in 2011. In lymph node, fingolimod acts as functional antagonist, leading to internalization of sphingosine-1-phosphate 1(S1P1) receptors of lymphocytes. Lymphocytes in lymph nodes bearing S1P1 receptors cannot egress from lymph nodes. As a result, lymphocyte count in the circulation is reduced. Fingolimod showed reduced relapses, and suppressed the number of enhancing lesion and the progression of brain atrophy of brain MRI, however, it also showed some adverse effects such as bradycardia, herpes zoster infection, macular edema, liver dysfunction, and teratogenic properties. We proposed indications of fingolimod therapy, and reduced dosage therapy of fingolimod for patients with a lymphocyte count below 0.2 x 10(9) cells/L. PMID:25518386

Tanaka, Masami

2014-11-01

200

Let's Practice Multiplication and Division!  

NSDL National Science Digital Library

Use the games below to improve your multiplication and division skills. Today, we are going to play some fun games that help us get better at multiplication and division. Follow the directions below: 1. Choose one of the following games. If you are a boy, you may wish to play with the catapult in Flight of the Knight. If you are a girl, you could ...

Aycock, Miss

2009-04-15

201

A Semantics of Multiple Inheritance  

Microsoft Academic Search

this paper is to present a clean semantics of multiple inheritance and to show that, in the context of strongly-typed, statically-scoped languages, a sound typechecking algorithm exists. Multiple inheritance is also interpreted in a broad sense: instead of being limited to objects, it is extended in a natural way to union types and to higher-order functional types. This constitutes a

Luca Cardelli

1988-01-01

202

[Borderline forms of multiple sclerosis].  

PubMed

Multiple sclerosis (MS) has been described for more than a century, but its cause remains unknown and no simple diagnostic marker is available. Therefore, it is not surprising that numerous articles were written on closely related diseases, borderline forms of multiple sclerosis. Different forms have been distinguished: a clinical form of MS (Devic's neuromyelitis optica), pathological forms (Balo, Schilder, Maburg), forms associated with MS (peripheral neuropathy, autoantibodies) and closely related disorders (acute disseminated encephalomyelitis). PMID:11787357

Fontaine, B

2001-09-01

203

Multiple oncocytomas and renal carcinoma  

SciTech Connect

Renal oncocytoma, although rare, is being diagnosed more frequently, and criteria to differentiate it from other tumors have been described. Multiple oncocytomas have been reported, but an association between multiple oncocytomas and renal carcinoma in the same kidney has not been described. The authors report a case with two oncocytomas and a renal carcinoma in the right kidney as well as a right adrenal adenoma.

Velasquez, G.; Glass, T.A.; D'Souza, V.J.; Formanek, A.G.

1984-01-01

204

The properties of close multiple stars  

NASA Technical Reports Server (NTRS)

A reexamination of the properties of close multiple systems is conducted, taking into account recent numerical, analytical, and observational results. The orbital elements of 43 spectroscopic multiple systems are presented in a table. Tables with photometry data of the systems and data describing their properties are also provided. Attention is given to period ratios, mass ratios, orbital coplanarity, stability, lithium abundances and age estimates, and prospects of future observations. Numerical studies indicate that fragmentation produces binary components with mass ratios usually close to 1.0, while fission usually produces mass ratios in the range 0.1-0.5. Using analytical stability criteria, all 27 close multiple systems considered are stable if they are corotating. If they are counter-rotating, four systems are possibly unstable. However, other factors suggest that even these four are probably stable. The solar-type close multiple systems ranged in age from 100 million years to 2,000 million years.

Fekel, F. C., Jr.

1981-01-01

205

The MARVEL assembly for neutron multiplication  

SciTech Connect

A new multiplying test assembly is under development at Idaho National Laboratory to support research, validation, evaluation, and learning. The item is comprised of three stacked, highly-enriched uranium (HEU) cylinders, each 11.4 cm in diameter and having a combined height of up to 11.7 cm. The combined mass of all three cylinders is 20.3 kg of HEU. Calculations for the bare configuration of the assembly indicate a multiplication level of >3.5 (keff=0.72). Reflected configurations of the assembly, using either polyethylene or tungsten, are possible and have the capability of raising the assembly's multiplication level to greater than 10. This paper describes simulations performed to assess the assembly's multiplication level under different conditions and describes the resources available at INL to support the use of these materials. We also describe some preliminary calculations and test activities using the assembly to study neutron multiplication.

David L. Chichester; Mathew T. Kinlaw

2013-10-01

206

The MARVEL assembly for neutron multiplication.  

PubMed

A new multiplying test assembly is under development at Idaho National Laboratory to support research, validation, evaluation, and learning. The item is comprised of three stacked, highly-enriched uranium (HEU) cylinders, each 11.4 cm in diameter and having a combined height of up to 11.7 cm. The combined mass of all three cylinders is 20.3 kg of HEU. Calculations for the bare configuration of the assembly indicate a multiplication level of >3.5 (k(eff)=0.72). Reflected configurations of the assembly, using either polyethylene or tungsten, are possible and have the capability of raising the assembly's multiplication level to greater than 10. This paper describes simulations performed to assess the assembly's multiplication level under different conditions and describes the resources available at INL to support the use of these materials. We also describe some preliminary calculations and test activities using the assembly to study neutron multiplication. PMID:23827507

Chichester, David L; Kinlaw, Mathew T

2013-10-01

207

Evolution of multiple sex chromosomes in the spider genus Malthonica (Araneae: Agelenidae) indicates unique structure of the spider sex chromosome systems  

Microsoft Academic Search

Most spiders exhibit a multiple sex chromosome system, X1X20, whose origin has not been satisfactorily explained. Examination of the sex chromosome systems in the spider genus Malthonica (Agelenidae) revealed considerable diversity in sex chromosome constitution within this group. Besides modes X1X20 (M. silvestris) and X1X2X30 (M. campestris), a neo-X1X2X3X4X5Y system in M. ferruginea was found. Ultrastructural analysis of spread pachytene

Ji?í Král

2007-01-01

208

Omnidirectional Video Capturing, Multiple People Tracking and  

E-print Network

. . . . . . . . . . . . . . . . . . . . . . . 11 4 Multiple Face Recognition 12 4.1 Preprocessing . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 5.2 Multiple face recognition . . . . . . . . . . . . . . . . . . . . . . . . 20 5.3 Multiple CAMEO (Camera Assisted Meeting Event Observer), a hardware/software component to record and monitor

De la Torre, Fernando

209

Modularization to Support Multiple Brand Platforms  

E-print Network

Methods to determine acceptable architecture for multiple platforms supporting multiple brands must represent both platform cost saving commonization as well as revenue enhancing brand distinctions. Functional architecting ...

Agus, Sudjianto

2001-09-09

210

Convergence characteristics of the multiple input, multiple output LMS algorithm  

NASA Technical Reports Server (NTRS)

The convergence characteristics of the multiple input, multiple output LMS algorithm, as applied to active noise and vibration control systems, are examined. The mean square error during the convergence process, as well as the final converged value, are examined analytically and in computer simulation. It is shown that the ratio of number of error sensors to number of control sources has a significant influence upon both the converging and converged value of the mean square error. Other active control system variables, such as the inherent time delays and structural/acoustic transfer functions, are also shown to have a significant influence upon the convergence process.

Snyder, Scott D.; Hansen, Colin H.; Clark, Robert L.

1992-01-01

211

Multiple vulnerabilities in SNMP  

Microsoft Academic Search

For more than a decade, many network administrators have relied on SNMP, the Simple Network Management Protocol, to monitor and manage network devices. Now in its third release, SNMP has become the de facto standard for network management since its development in 1987. However, a recent report from the computer security watchdog CERT Coordination Center indicates that vulnerabilities in many

G. Jiang

2002-01-01

212

Pyrochemical neutron multiplicity counter design  

SciTech Connect

Pyrochemical process materials are difficult to measure using conventional neutron counting methods because of significant self- multiplication and variable ({alpha},n) reaction rates. Multiplicity counters measure the first three moments of the neutron multiplicity distribution and thus make it possible to determine sample mass even when multiplication and ({alpha},n) rate are unknown. A new multiplicity counter suitable for inplant measurement of pyrochemical process materials has been designed using Monte Carlo simulations. The goals were to produce a counter that has high neutron detection efficiency, low die-away time, a flat spatial efficiency profile, and is insensitive to the neutron energy spectrum. Monte Carlo calculations were performed for several prototype models consisting of four rings of 71-cm active length {sup 3}He tubes in a polyethylene body. The cadmium-lined sample well is 25 cm in diameter to accommodate a wide variety of inplant sample containers. The counter can be free-standing or in-line without mechanical modification. The calculations were performed to determine the above design criteria for several configurations of tube spacing, cadmium liners, and sample height. Calculations were also performed for distributed sample sources to understand the integrated effects of variable neutron spectra on the counter. 5 refs., 8 figs., 1 tab.

Langner, D.G.; Ensslin, N.; Krick, M.S.

1990-01-01

213

Childbirth Education for Multiple Pregnancy  

PubMed Central

Women with a multiple pregnancy have unique learning needs in preparing for birth. This paper explores the issues relevant to women with a multiple pregnancy to support a positive birth experience. One of the foundations of childbirth education and nursing care is to provide the individual woman and her family with knowledge regarding the birth process, what to expect, and how to cope with labor and birth. Education also focuses on caring for the newborns after birth and how to manage in the early days at home. However, traditional childbirth education classes, which meet in a series of evenings or Saturdays, may not meet the needs of women with a multiple pregnancy. In addition, because of the differences in care that exist for women with a multiple pregnancy, new paradigms for childbirth education are needed to meet the learning needs of these families. The purpose of this paper is to provide information to the childbirth educator on the differences in care women with a multiple pregnancy can expect and to suggest strategies to meet the childbirth education needs of these families. PMID:17273430

Montgomery, Kristen S.; Cubera, Sabrina; Belcher, Christie; Patrick, David; Funderburk, Heather; Melton, Christa; Fastenau, Michelle

2005-01-01

214

Allogeneic transplantation in multiple myeloma.  

PubMed

Allogeneic transplantation has the potential to cure subgroups of patients with multiple myeloma, but its role is controversial due to high transplant-related mortality. Therefore, myeloablative allogeneic transplantation has fallen out of favor. Allogeneic transplantation using reduced-intensity conditioning (RICallo) has lower transplant-related mortality and may be an option for subgroups of patients. Upfront tandem autologous/RICallo (auto/RICallo) was shown to be superior to single auto or tandem auto/auto in both progression-free and overall survival in two studies with long-term follow-up, while four similarly designed studies with shorter follow-up did not show a significant advantage. All studies included patients less than 70 years of age. No study has shown that the auto/RICallo approach is inferior to auto or auto/auto. There have been indications that poor-risk cytogenetics may be overcome by the auto/RICallo approach. Encouraging results have also been seen in treatment of relapsed patients. Small studies indicate that combining allogeneic transplant with new proteasome inhibitors and immunomodulatory drugs may further improve results. Prospective studies including these drugs for induction, conditioning and post-allogeneic transplant maintenance are warranted and planned. New cell therapies, such as with natural killer cells have shown encouraging results in experimental animals and should be tried in combination with allotransplantation. PMID:24224804

Gahrton, Gösta; Krishnan, Amrita

2014-02-01

215

Constraining multiple systems with GAIA  

NASA Astrophysics Data System (ADS)

GAIA will provide observations of some multiple asteroid and dwarf systems. These observations are a way to determine and improve the quantification of dynamical parameters, such as the masses and the gravity fields, in these multiple systems. Here we investigate this problem in the cases of Pluto's and Eugenia's system. We simulate observations reproducing an approximate planning of the GAIA observations for both systems, as well as the New Horizons observations of Pluto. We have developed a numerical model reproducing the specific behavior of multiple asteroid system around the Sun and fit it to the simulated observations using least-square method, giving the uncertainties on the fitted parameters. We found that GAIA will improve significantly the precision of Pluto's and Charon's mass, as well as Petit Prince's orbital elements and Eugenia's polar oblateness.

Beauvalet, L.; Lainey, V.; Arlot, J.-E.; Bancelin, D.; Binzel, R. P.; Marchis, F.

2012-12-01

216

Subpixel resolution from multiple images  

NASA Technical Reports Server (NTRS)

Multiple images taken from similar locations and under similar lighting conditions contain similar, but not identical, information. Slight differences in instrument orientation and position produces mismatches between the projected pixel grids. These mismatches ensure that any point on the ground is sampled differently in each image. If all the images can be registered with respect to each other to a small fraction of a pixel accuracy, then the information from the multiple images can be combined to increase linear resolution by roughly the square root of the number of images. In addition, the gray-scale resolution of the composite image is also improved. We describe methods for multiple image registration and combination, and discuss some of the problems encountered in developing and extending them. We display test results with 8:1 resolution enhancement, and Viking Orbiter imagery with 2:1 and 4:1 enhancements.

Cheeseman, Peter; Kanefsky, Rob; Stutz, John; Kraft, Richard

1994-01-01

217

Gd[subscript 13]Fe[subscript 10]C[subscript 13]: Indications of Fe?Fe Multiple Bonding Emerging from Chemical Frustration  

SciTech Connect

We report the synthesis and crystal structure of the carbide Gd{sub 13}Fe{sub 10}C{sub 13}. This compound adopts a new structure type that is remarkable for its 'H'-shaped C{sub 2}FeFeC{sub 2} units, which have some of the shortest Fe-Fe contacts known. A bonding analysis using DFT-calibrated Hueckel calculations hints that Fe-Fe multiple bonding underlies these short distances. Gd{sub 13}Fe{sub 10}C{sub 13} undergoes ferromagnetic ordering at {approx}55 K.

Hadler, Amelia B.; Fredrickson, Daniel C. (UW)

2012-10-25

218

Multiple Imputation Strategies for Multiple Group Structural Equation Models  

ERIC Educational Resources Information Center

Although structural equation modeling software packages use maximum likelihood estimation by default, there are situations where one might prefer to use multiple imputation to handle missing data rather than maximum likelihood estimation (e.g., when incorporating auxiliary variables). The selection of variables is one of the nuances associated…

Enders, Craig K.; Gottschall, Amanda C.

2011-01-01

219

Goiter and Multiple Food Allergies  

PubMed Central

Severe iodine deficiency results in impaired thyroid hormone synthesis and thyroid enlargement. In the United States, adequate iodine intake is a concern for women of childbearing age and pregnant women. Beyond this high risk group iodine deficiency is not considered to be a significant problem. This case report describes a 12-year-old male with severe iodine deficiency disorder (IDD) resulting from restricted dietary intake due to multiple food allergies. We describe iodine replacement for this patient and continued monitoring for iodine sufficiency. Children with multiple food allergies, in particular those with restrictions to iodized salt and seafood, should be considered high risk for severe iodine deficiency. PMID:19956702

Leniszewski, Stefanie; Mauseth, Richard

2009-01-01

220

Topics in multiple hypotheses testing  

E-print Network

procedures. The B-H procedure controls the error rate for all values of m0 without using any information in the data about m0. Often, the power of the multiple hypothesis testing method, E(S/m1), decreases when the number of hypotheses tested, m, increases...(Q(?)) is the density quantile function (Parzen 1979). In multiple hypotheses testing, there exist p-values p1,? ? ? ,pm with distribution function G. Let ui = i/m and Yi = m(p(i) - p(i-1)). Then Y1,? ? ? ,Ym are approx- imately independent, and Yi is approximately...

Qian, Yi

2007-04-25

221

Multiple order common path spectrometer  

NASA Technical Reports Server (NTRS)

The present invention relates to a dispersive spectrometer. The spectrometer allows detection of multiple orders of light on a single focal plane array by splitting the orders spatially using a dichroic assembly. A conventional dispersion mechanism such as a defraction grating disperses the light spectrally. As a result, multiple wavelength orders can be imaged on a single focal plane array of limited spectral extent, doubling (or more) the number of spectral channels as compared to a conventional spectrometer. In addition, this is achieved in a common path device.

Newbury, Amy B. (Inventor)

2010-01-01

222

Suicide using multiple crossbow arrows.  

PubMed

We report the case of a 44-year-old man who committed suicide using multiple crossbow arrows. The first arrow that he fired went between the left eye and nose and passed into a frontal lobe of the brain with no exit wound. He fired a second arrow that entered the palate and went through the brain but did not exit the skull. To the best of our knowledge, no cases of suicide using multiple crossbow arrows have previously been reported. PMID:8166108

Opeskin, K; Burke, M

1994-03-01

223

Immunotherapy strategies in multiple myeloma.  

PubMed

Multiple myeloma (MM) is a B-cell malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow and the development of osteolytic bone lesions. MM has emerged as a paradigm within the cancers for the success of drug discovery and translational medicine. This article discusses immunotherapy as an encouraging option for the goal of inducing effective and long-lasting therapeutic outcome. Divided into two distinct approaches, passive or active, immunotherapy, which targets tumor-associated antigens has shown promising results in multiple preclinical and clinical studies. PMID:25212890

Bae, Jooeun; Munshi, Nikhil C; Anderson, Kenneth C

2014-10-01

224

Multiple Spontaneous Simultaneous Intracerebral Hemorrhages  

PubMed Central

Simultaneous occurrence of intracerebral hemorrhage (ICH) in different arterial territories is an uncommon event. We report on two cases of multiple spontaneous simultaneous ICH for which we could find no specific cause. A 73-year-old man, with no related medical history, was admitted to the hospital with simultaneous bithalamic ICH, and subsequently died of recurrent pneumonia. Second patient was a 60-year-old man who presented with simultaneous ICH in the pons and thalamus; he died of recurrent bleeding. We review the possible pathological mechanisms, clinical and radiologic features of simultaneous multiple ICH. PMID:25045650

Seo, Jin-Suk; Nam, Taek-Kyun; Kwon, Jeong-Taik

2014-01-01

225

Multiple resonant railgun power supply  

DOEpatents

A multiple repetitive resonant railgun power supply provides energy for repetitively propelling projectiles from a pair of parallel rails. A plurality of serially connected paired parallel rails are powered by similar power supplies. Each supply comprises an energy storage capacitor, a storage inductor to form a resonant circuit with the energy storage capacitor and a magnetic switch to transfer energy between the resonant circuit and the pair of parallel rails for the propelling of projectiles. The multiple serial operation permits relatively small energy components to deliver overall relatively large amounts of energy to the projectiles being propelled.

Honig, Emanuel M. (Los Alamos, NM); Nunnally, William C. (Los Alamos, NM)

1988-01-01

226

Multiple resonant railgun power supply  

DOEpatents

A multiple repetitive resonant railgun power supply provides energy for repetitively propelling projectiles from a pair of parallel rails. A plurality of serially connected paired parallel rails are powered by similar power supplies. Each supply comprises an energy storage capacitor, a storage inductor to form a resonant circuit with the energy storage capacitor and a magnetic switch to transfer energy between the resonant circuit and the pair of parallel rails for the propelling of projectiles. The multiple serial operation permits relatively small energy components to deliver overall relatively large amounts of energy to the projectiles being propelled.

Honig, E.M.; Nunnally, W.C.

1985-06-19

227

Management of multiple impacted teeth.  

PubMed

An impacted or missing permanent tooth can add significant complications to an otherwise straightforward case. When multiple impacted teeth are present, the case complexity increases further. Developing a treatment sequence, determining appropriate anchorage, and planning and executing sound biomechanics can be a challenge. The following case report illustrates a patient with three retained primary teeth and three impacted permanent canines. After careful treatment planning and extraction of multiple primary teeth;, followed by attempted guided eruption of impacted teeth, the patient finished with a significantly improved functional and aesthetic result. PMID:22557915

Bansal, Nidhi; Valiathan, Ashima; Bansal, Kshitij; Parkar, Farhan

2012-01-01

228

SPSS Tutorial for Multiple Comparisons  

NSDL National Science Digital Library

Authored by Laura Little of the University of Washington, this tutorial exposes students to conducting multiple comparisons in SPSS. This html based tutorial provides extensive screen shots and an example data set. Topics covered in the tutorial include: one way ANOVA, preplanned contrasts, Bonferroni, Post Hoc Tukey's HSD, and Scheffe's multiple contrasts. This is a great example of how to use statistical tools such as SPSS in a psychological statistics course. Little does excellent work in providing a step by step approach to learning these methods.

Little, Laura

2009-03-11

229

Development of a Multimorbidity Illness Perceptions Scale (MULTIPleS)  

PubMed Central

Background Illness perceptions are beliefs about the cause, nature and management of illness, which enable patients to make sense of their conditions. These perceptions can predict adjustment and quality of life in patients with single conditions. However, multimorbidity (i.e. patients with multiple long-term conditions) is increasingly prevalent and a key challenge for future health care delivery. The objective of this research was to develop a valid and reliable measure of illness perceptions for multimorbid patients. Methods Candidate items were derived from previous qualitative research with multimorbid patients. Questionnaires were posted to 1500 patients with two or more exemplar long-term conditions (depression, diabetes, osteoarthritis, coronary heart disease and chronic obstructive pulmonary disease). Data were analysed using factor analysis and Rasch analysis. Rasch analysis is a modern psychometric technique for deriving unidimensional and intervally-scaled questionnaires. Results Questionnaires from 490 eligible patients (32.6% response) were returned. Exploratory factor analysis revealed five potential subscales ‘Emotional representations’, ‘Treatment burden’, ‘Prioritising conditions’, ‘Causal links’ and ‘Activity limitations’. Rasch analysis led to further item reduction and the generation of a summary scale comprising of items from all scales. All scales were unidimensional and free from differential item functioning or local independence of items. All scales were reliable, but for each subscale there were a number of patients who scored at the floor of the scale. Conclusions The MULTIPleS measure consists of five individual subscales and a 22-item summary scale that measures the perceived impact of multimorbidity. All scales showed good fit to the Rasch model and preliminary evidence of reliability and validity. A number of patients scored at floor of each subscale, which may reflect variation in the perception of multimorbidity. The MULTIPleS measure will facilitate research into the impact of illness perceptions on adjustment, clinical outcomes, quality of life, and costs in patients with multimorbidity. PMID:24376504

Gibbons, Chris J.; Kenning, Cassandra; Coventry, Peter A.; Bee, Penny; Bundy, Christine; Fisher, Louise; Bower, Peter

2013-01-01

230

On the Time Required to Perform Multiplication  

Microsoft Academic Search

The time required to perform multiplication is investigated. A lower bound on the time required to perform multiplication, as well as multiplication modulo N, is derived and it is shown that these lower bounds can be approached. Then a lower bound on the amount of time required to perform the most significant part of multiplication (⌞xy\\/N⌟) is derived.

Shmuel Winograd; Yorktown Heights

1967-01-01

231

Professional Skepticism of Multiple Personality Disorder  

Microsoft Academic Search

If you saw a patient who appeared to have more than one personality, what diagnosis would you make? And how would you vary your clinical approach? Data from 425 respondents indicated that the majority of psychologists believed multiple personality disorder (MPD) to be a valid but rare clinical diagnosis. Respondents cited extreme child abuse as the foremost cause of MPD.

Jane F. Cormier; Mark H. Thelen

1998-01-01

232

Zoom Zoom: racing CARs for multiple myeloma.  

PubMed

Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma. PMID:23444214

Maus, Marcela V; June, Carl H

2013-04-15

233

Zoom zoom: racing CARs for multiple myeloma  

PubMed Central

Summary Chimeric antigen receptors re-direct T cells to surface antigens. Discovery and validation of appropriate target antigens expands the possible indications for CAR-T cells. BCMA is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma. PMID:23444214

Maus, Marcela V.; June, Carl H.

2013-01-01

234

Stable isotope values (?18O & ?13C) of multiple ostracode species in a large Neotropical lake as indicators of past changes in hydrology  

NASA Astrophysics Data System (ADS)

Modern lake hydrodynamics, ostracode species autecology, stable isotopes (?18O and ?13C) of multiple ostracode species, ostracode taphonomy and sediment geochemistry were studied to improve interpretation of the late Pleistocene-early Holocene (?24-10 ka) stable isotope record of ostracodes in sediment core PI-6 from Lago Petén Itzá, northern Guatemala. Oxygen and carbon stable isotopes in modern and fossil species assemblages of Lago Petén Itzá were used as indicators of changes in the balance between evaporation and precipitation, past lake level and carbon source. Ostracode taphonomy was used to detect past periods of strong currents, high-energy environments, and possible partial or full mixing of the lake. The modern lake water isotopic composition displays clear seasonal differences that are independent of lake level fluctuations. Modern benthic species displayed lower ?18O and ?13C values than nektobenthic species, with differences of 3.0‰ and 5.3‰, respectively. Valves of nektobenthic species display higher values of ?13C because these ostracodes live in shallower environments among abundant algae and aquatic plants, where productivity is high. The benthic species Limnocythere opesta Brehm, 1939 displayed the smallest average offset from ?18O water (+0.3‰) and the largest offset from ?13CDIC values (-4.1‰) among studied ostracode species. Nektobenthic species Heterocypris punctata Keyser, 1975 displayed the smallest difference relative to the ?13CDIC values (-0.1‰). Late Pleistocene-early Holocene climate conditions and water levels in Lago Petén Itzá can be summarized as follows: 1) high lake levels and cold conditions (Last Glacial Maximum [LGM], ?24-19 ka), 2) fluctuating lake levels and cold conditions (Heinrich Stadial 1 [HS1], ?19-15 ka), 3) high lake levels and warm and wetter conditions (Bølling-Allerød [BA], ?15-13 ka), 4) low lake levels and dry conditions (Younger Dryas [YD], ?13-11.5 ka) and 5) high lake levels and warm and wetter conditions (early Holocene, ?11.5-10.0 ka). Average lake level fluctuation in Lago Petén Itzá during the late Pleistocene-early Holocene was as much as ?25 m. Ostracode analyses suggest that the LGM was characterized by relatively low ?18O (+4.7 to +6.0‰), and ?13C values (-7.1 to -6.4‰) in ostracode valves, high inferred water depths and high percentages of broken adult and juvenile valves (>66%), suggesting a high-energy environment, strong currents, partial to full mixing, downslope transport, colder water temperatures and wetter conditions. An increase in the relative abundance of the benthic species L. opesta and higher numbers of broken valves suggest heavy precipitation events during the LGM (?23.7, 21.7, 20.8 and 20.1 ka). HS1 was predominantly dry, but we identified times when lake levels were slightly higher, at the onset of the deglacial and a brief period (?17-16 ka) between HS1b and HS1a. All studied climate proxies indicate wetter and warmer conditions and lake system stability during the BA. Lake levels dropped during the YD and gradually increased during the Preboreal and early Holocene. We demonstrate that modern and fossil ostracode isotopic signatures, species assemblages and taphonomy can be used together with physical and geochemical variables in Lago Petén Itzá sediments to make high-resolution inferences about late Pleistocene-early Holocene environmental changes in the lowland Neotropics.

Pérez, Liseth; Curtis, Jason; Brenner, Mark; Hodell, David; Escobar, Jaime; Lozano, Socorro; Schwalb, Antje

2013-04-01

235

Matrix multiplication via arithmetic progressions  

Microsoft Academic Search

We present a new method for accelerating matrix multiplication asymptotically. This work builds on recent ideas of Volker Strassen, by using a basic trilinear form which is not a matrix product. We make novel use of the Salem-Spencer Theorem, which gives a fairly dense set of integers with no three-term arithmetic progression. Our resulting matrix exponent is 2.376.

Don Coppersmith; Shmuel Winograd

1987-01-01

236

Multiple Stars in the Field  

NASA Astrophysics Data System (ADS)

When examining the statistics of multiple stars in the field, especially coming from visual binary star point of view, several problems present themselves. First, and most importantly, is distinguishing between physical multiples and optical pairs. Establishing physicality is not a simple "binary" response as there are degrees of certainty. We discuss some of the reasons for caring about non-physical pairs, as well as the tools for establishing or more correctly identifying apparent kinematic properties which hopefully result in dynamic solutions. The Washington Double Star Catalog, the Visual Orbit Catalog, and the US Naval Observatory speckle program are used as examples in many of these cases. The magnum opus for a global characterization of these systems is the Washington Multiplicity Catalog (WMC). Selected as a catalog and a method to "develop a simple, unambiguous, flexible, and computer friendly designation scheme for stellar companions (including planets)" at a multi-commission meeting in Manchester (GA24). This was re-affirmed at Special Session 3 in Sydney (GA25) by Commissions 5, 8, 26, 42, 45 and the Working Group on Interferometry when a sample (1/2 hour band) WMC was produced. An all-sky WMC is in progress the binary sources utilized in its construction and the implications resulting from it with regards to multiple stars in the field are discussed.

Mason, Brian D.; Hartkopf, William I.

237

Interoperability of multiple autonomous databases  

Microsoft Academic Search

Database systems were a solution to the problem of shared access to heterogeneous files created by multiple autonomous applications in a centralized environment. To make data usage easier, the files were replaced by a globally integrated database. To a large extent, the idea was successful, and many databases are now accessible through local and long-haul networks. Unavoidably, users now need

Witold Litwin; Leo Mark; Nick Roussopoulos

1990-01-01

238

Corticial lesions in multiple sclerosis  

Microsoft Academic Search

Summary Although previous studies have shown that the lesions of multiple sclerosis may involve the cerebral cortex, there is little published research on the prevalence and distribution of such lesions. Using neuropathological techniques and MRI, a series of studies has been undertaken in order to assess this, in particular to identify their relationship to cortical veins. A serial MRI study

D. Kidd; F. Barkhof; R. McConnell; P. R. Algra; I. V. Allen; T. Revesz

1999-01-01

239

Fashion, Paper Dolls and Multiplicatives  

ERIC Educational Resources Information Center

The multiplicative principle is the tool allowing the counting of groups that can be described by a sequence of events. An event is a subset of sample space, i.e. a collection of possible outcomes, which may be equal to or smaller than the sample space as a whole. It is important that students understand this basic principle early on and know how…

Ura, Suzana Kaori; Stein-Barana, Alzira C. M.; Munhoz, Deisy P.

2011-01-01

240

Multiple Choice Questions for Groundwater  

NSDL National Science Digital Library

This online quiz was written by Dr. John C. Butler at the University of Houston for 100-level geology students. There are 44 multiple choice questions and 8 fill in the blank questions, Topics include groundwater resources, the water cycle, karst features, the water table and parts of an aquifer. Answers are linked directly from the quiz page.

John C. Butler

241

Characteristics of Multiple Comparison Procedures.  

ERIC Educational Resources Information Center

Multiple comparison procedures (MCPs), in the context of analysis of variance, are becoming more popular than the overall F tests. An attempt is made to clarify confusion among the different MCPs by systematically comparing and contrasting the procedures in terms of their purposes, restrictions, robustness to assumptions, and other special…

Yusuf, Mian Muhammad; And Others

242

Venom therapy in multiple sclerosis  

Microsoft Academic Search

To date many people with multiple sclerosis (MS) seek complementary and alternative medicines (CAM) to treat their symptoms as an adjunct to conventionally used therapies. Among the common CAM therapies, there is a renewed interest in the therapeutic potential of venoms in MS. The efficacy of this therapeutic method remains unclear. However, venom-based therapy using bee, snakes and scorpions venom

Abbas Mirshafiey

2007-01-01

243

Development of multiple media documents  

Microsoft Academic Search

Development of documents in multiple media involves activities in three different fields, the technical, the discoursive and the procedural. The major development problems of artifact complexity, cognitive processes, design basis and working context are located where these fields overlap. Pending the emergence of a unified approach to design, any method must allow for development at the three levels of discourse

Stephen J. Morris; Anthony Finkelstein

1993-01-01

244

Childhood Multiple Sclerosis: A Review  

ERIC Educational Resources Information Center

Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS) that is increasingly recognized as a disease that affects children. Similar to adult-onset MS, children present with visual and sensory complaints, as well as weakness, spasticity, and ataxia. A lumbar puncture can be helpful in diagnosing MS when…

Waldman, Amy; O'Connor, Erin; Tennekoon, Gihan

2006-01-01

245

Bacterial toxins and Multiple Sclerosis  

Microsoft Academic Search

The primary pathogenetic mechanism responsible for the distinctive demyelinating lesions in the Central Nervous System (CNS) in Multiple Sclerosis (MS), first described in remarkable detail by Charcot more than 170 years ago, remains one of the most baffling conundrums in medicine. A possible role for bacterial cell molecules and transportable proteins in the pathogenesis of MS is reviewed. The ability

Frederick Gay

2007-01-01

246

Fungible Weights in Multiple Regression  

ERIC Educational Resources Information Center

Every set of alternate weights (i.e., nonleast squares weights) in a multiple regression analysis with three or more predictors is associated with an infinite class of weights. All members of a given class can be deemed "fungible" because they yield identical "SSE" (sum of squared errors) and R[superscript 2] values. Equations for generating…

Waller, Niels G.

2008-01-01

247

Cerebral palsy and multiple births  

Microsoft Academic Search

AIM: To compare the birthweight specific prevalence of cerebral palsy in singleton and multiple births. METHODS: Registered births of babies with cerebral palsy born to mothers resident in the counties of Merseyside and Cheshire during the period 1982 to 1989 were ascertained. RESULTS: The crude prevalence of cerebral palsy was 2.3 per 1000 infant survivors in singletons, 12.6 in twins,

P O Pharoah; T Cooke

1996-01-01

248

Multigenre, Multiple Intelligences, and Transcendentalism.  

ERIC Educational Resources Information Center

Explains an eleventh grade literature unit on Transcendentalism which employed a wide variety of supplemental materials and literary connections and which provided alternate assessment opportunities. Details how this unit revealed meaningful connections through comics, music, free reading, and multiple intelligences. Concludes that many students…

Ruggieri, Colleen A.

2002-01-01

249

Natural history of multiple meningiomas  

PubMed Central

Background: Asymptomatic solitary meningiomas are typically managed with clinical and radiographic follow-up. Multiple meningiomas represents a clinical entity distinct from solitary meningiomas and can be sporadic, radiation-induced, associated with neurofibromatosis, or exhibit other familial inheritance. The growth rate for multiple meningiomas is not known and therefore management of these complicated patients can be difficult. Methods: A retrospective chart review was performed on 12 patients with a total of 55 meningiomas. Patients with neurofibromatosis were not included. Serial enhanced magnetic resonance imaging was used to determine tumor growth rates. Treatment history was also reviewed and included for analysis. Results: Analysis of all 55 tumors demonstrated an average rate of growth of 0.46 cm3/year (range: ?0.57-2.94 cm3/year). In the 23 tumors that received no treatment, the average rate of growth was 0.34 cm3/year (range: ?0.03-1.8 cm3/year). Ten of the 23 tumors that received no treatment had no history of cranial irradiation. This group demonstrated a growth rate of 0.44 cm3/year (range: ?0.01-1.8 cm3/year). Linear regression analysis did not yield any significant relationship between tumor burden and rates of growth. Conclusion: Tumor growth rates in patients with multiple meningiomas did not appear to be higher than reported rates for incidentally found solitary meningiomas. As such, asymptomatic multiple meningioma patients should be managed with clinical and radiographic follow-up. PMID:23776757

Wong, Ricky H.; Wong, Andrew K.; Vick, Nicholas; Farhat, Hamad I.

2013-01-01

250

Symptomatic Treatment of Multiple Sclerosis  

Microsoft Academic Search

Besides immunomodulation and immunosuppression, the specific treatment of symptoms is an essential component of the overall management of multiple sclerosis (MS). Symptomatic treatment is aimed at the elimination or reduction of symptoms impairing the functional abilities and quality of life of the affected patients. Moreover, with symptomatic treatment the development of a secondary physical impairment due to an existing one

T. Henze; P. Rieckmann; K. V. Toyka

2006-01-01

251

Multiple Pathways for All Students  

ERIC Educational Resources Information Center

Maine has been focusing on the importance of postsecondary training. Maine's Skowhegan Area High School (SAHS) and Somerset Career and Technical Center (SCTC) have partnered in a Multiple Pathways initiative (funded by the Nellie Mae Education Foundation) to increase students' high school completion rate and to increase enrollment in postsecondary…

Stirling, Lee Anna

2012-01-01

252

Investigations on Multiplication of Fractions.  

ERIC Educational Resources Information Center

Three different models with continuous materials, discontinuous materials, and number lines were used to study the operation concept in six investigations on multiplication with fractions with pupils aged 11-12 in a Penang International School. All approaches could be understood by pupils, but they preferred the area and fractional models. (MNS)

Sai, Khoo Phon; Inder, Walter R. D.

1984-01-01

253

Inferring constraints from multiple snapshots  

Microsoft Academic Search

Many graphic tasks, such as the manipulation of graphical objects and the construction of user-interface widgets, can be facilitated by geometric constraints. However, the difficulty of specifying constraints by traditional methods forms a barrier to their widespread use. In order to make constraints easier to declare, we have developed a method of specifying constraints implicitly, through multiple examples. Snapshots are

David Kurlander; Steven Feiner

1993-01-01

254

Presentation 7: Multiple Primary Rules  

Cancer.gov

MP Rules - Note 2 The registrar must recognize that during the diagnostic workup the physician may start with a non-specific diagnosis (NOS) and as testing is completed, a more specific histology is identified. These diagnoses are not multiple primaries; they represent steps in the diagnostic work-up. See rules M7-M12.

255

Multiple endocrine neoplasia type 1  

Microsoft Academic Search

The recent cloning of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1) has opened new avenues for both clinical and basic science research in the field of endocrine oncology. A large amount of genetic information, particularly those in relation to germline and somatic mutations, has since been published during the last 2 years. This new knowledge has

Fung Ki Wong; John Burgess; Magnus Nordenskjöld; Catharina Larsson; Bin Tean Teh

2000-01-01

256

Time-domain multiple-quantum NMR  

SciTech Connect

The development of time-domain multiple-quantum nuclear magnetic resonance is reviewed through mid 1982 and some prospects for future development are indicated. Particular attention is given to the problem of obtaining resolved, interpretable, many-quantum spectra for anisotropic magnetically isolated systems of coupled spins. New results are presented on a number of topics including the optimization of multiple-quantum-line intensities, analysis of noise in two-dimensional spectroscopy, and the use of order-selective excitation for cross polarization between nuclear-spin species.

Weitekamp, D.P.

1982-11-01

257

Iron chelation and multiple sclerosis.  

PubMed

Histochemical and MRI studies have demonstrated that MS (multiple sclerosis) patients have abnormal deposition of iron in both gray and white matter structures. Data is emerging indicating that this iron could partake in pathogenesis by various mechanisms, e.g., promoting the production of reactive oxygen species and enhancing the production of proinflammatory cytokines. Iron chelation therapy could be a viable strategy to block iron-related pathological events or it can confer cellular protection by stabilizing hypoxia inducible factor 1?, a transcription factor that normally responds to hypoxic conditions. Iron chelation has been shown to protect against disease progression and/or limit iron accumulation in some neurological disorders or their experimental models. Data from studies that administered a chelator to animals with experimental autoimmune encephalomyelitis, a model of MS, support the rationale for examining this treatment approach in MS. Preliminary clinical studies have been performed in MS patients using deferoxamine. Although some side effects were observed, the large majority of patients were able to tolerate the arduous administration regimen, i.e., 6-8 h of subcutaneous infusion, and all side effects resolved upon discontinuation of treatment. Importantly, these preliminary studies did not identify a disqualifying event for this experimental approach. More recently developed chelators, deferasirox and deferiprone, are more desirable for possible use in MS given their oral administration, and importantly, deferiprone can cross the blood-brain barrier. However, experiences from other conditions indicate that the potential for adverse events during chelation therapy necessitates close patient monitoring and a carefully considered administration regimen. PMID:24397846

Weigel, Kelsey J; Lynch, Sharon G; LeVine, Steven M

2014-01-01

258

Multiple states in river and lake ecosystems.  

PubMed Central

Nonlinear models of ecosystem dynamics that incorporate positive feedbacks and multiple, internally reinforced states have considerable explanatory power. However, linear models may be adequate, particularly if ecosystem behaviour is primarily controlled by external processes. In lake ecosystems, internal (mainly biotic) processes are thought to have major impacts on system behaviour, whereas in rivers, external (mainly physical) factors have traditionally been emphasized. We consider the hypothesis that models that exhibit multiple states are useful for understanding the behaviour of lake ecosystems, but not as useful for understanding stream ecosystems. Some of the best-known examples of multiple states come from lake ecosystems. We review some of these examples, and we also describe examples of multiple states in rivers. We conclude that the hypothesis is an oversimplification; the importance of physical forcing in rivers does not eliminate the possibility of internal feedbacks that create multiple states, although in rivers these feedbacks are likely to include physical as well as biotic processes. Nonlinear behaviour in aquatic ecosystems may be more common than current theory indicates. PMID:12079525

Dent, C Lisa; Cumming, Graeme S; Carpenter, Stephen R

2002-01-01

259

Operational Momentum in Multiplication and Division?  

PubMed Central

Biases are commonly seen in numerical cognition. The operational momentum (OM) effect shows that responses to addition and subtraction problems are biased in the whole-number direction of the operation. It is not known if this bias exists for other arithmetic operations. To determine whether OM exists in scalar operations, we measured response bias in adults performing symbolic (Arabic digits) and non-symbolic (dots) multiplication and division problems. After seeing two operands, with either a multiplication (×) or division (÷) sign, participants chose among five response choices. Both non-random performance profiles and the significant contribution of both operands in a multiple regression analysis predicting the chosen values, suggest that adults were able to use numerical information to approximate the outcomes in both notations, though they were more accurate on symbolic problems. Performance on non-symbolic problems was influenced by the size of the correct choice relative to alternatives. Reminiscent of the bias in addition and subtraction, we found a significant response bias for non-symbolic problems. Non-symbolic multiplication problems were overestimated and division problems were underestimated. These results indicate that operational momentum is present in non-symbolic multiplication and division. Given the influence of the size of the correct choice relative to alternatives, an interaction between heuristic bias and approximate calculation is possible. PMID:25121951

Katz, Curren; Knops, André

2014-01-01

260

Moving target tracking using multiple sensors  

NASA Astrophysics Data System (ADS)

Multiple Sensors improve tracking performance. The Kinematic Automatic Tracker (KAT) may drop a track when the Joint STARS aircraft is turning or the track is screened. In situation like this multiple sensors can improve tracking performance. Two algorithms for tracking moving targets using multiple sensors are developed. Both algorithms are based on modifying the existing KAT architecture. The first approach is based on the use of the best sensor's Moving Target Indicators (MTIs) when the sensors have overlapping dwells. The second and more general approach uses the report-to-track fusion algorithm. The first approach is frame- based (with multiple dwells), whereas the second approach is dwell- based. The tracking results are presented for the first algorithm for a two-sensors Korean scenario with increasing complexity. We also show the advantages of using multiple sensors for tracking using a simulated Korea scenario. For the report-to-track fusion algorithm, we present preliminary tracking results for a simulated scenario using two UAV sensors.

Lodaya, Manikant D.; Bottone, Richard

2000-07-01

261

MULTIPLE SULFUR ISOTOPE FRACTIONATIONS IN BIOLOGICAL SYSTEMS: A CASE STUDY WITH SULFATE REDUCERS  

E-print Network

MULTIPLE SULFUR ISOTOPE FRACTIONATIONS IN BIOLOGICAL SYSTEMS: A CASE STUDY WITH SULFATE REDUCERS*, DONALD E. CANFIELD**, and KIRSTEN S. HABICHT** ABSTRACT. Multiple sulfur isotope measurements of sulfur disproportionation indicate that different types of metabolic processes impart differ- ent multiple isotope

Kaufman, Alan Jay

262

[Combination chemotherapy of multiple myeloma].  

PubMed

Seventy patients with progressive multiple myeloma received combination chemotherapy with cyclophosphamide and prednisolone (CP), BCNU, cyclophosphamide, procarbazine and prednisolone (BCPP), and MCNU, cyclophosphamide, melphalan and prednisolone (MCMP) as first line treatment. Total remission rate in patients treated with CP, BCPP, and MCMP was 76.2%, 86.1%, and 91%, and complete response rate 26.1%, 33.3% and 63.7%, respectively, 5-yr survival in the patients treated with CP and BCPP regimen was 51.9 +/- 11.1%, 39.7 +/- 8.9%, respectively, however, the difference was not significant, 1-yr survival in the patients treated with MCMP was 91 +/- 8.7%. It was postulated that long-term survival or cure can only be anticipated if the treatments giving high CR rates was developed. The study, though preliminary, supports the notion that MCMP therapy should be used as primary standard treatment for patients with multiple myeloma. PMID:2389944

Uzuka, Y; Saito, Y; Ito, T

1990-08-01

263

Multiple Exciton Generation Solar Cells  

SciTech Connect

Heat loss is the major factor limiting traditional single junction solar cells to a theoretical efficiency of 32%. Multiple Exciton Generation (MEG) enables efficient use of the solar spectrum yielding a theoretical power conversion efficiency of 44% in solar cells under 1-sun conditions. Quantum-confined semiconductors have demonstrated the ability to generate multiple carriers but present-day materials deliver efficiencies far below the SQ limit of 32%. Semiconductor quantum dots of PbSe and PbS provide an active testbed for developing high-efficiency, inexpensive solar cells benefitting from quantum confinement effects. Here, we will present recent work of solar cells employing MEG to yield external quantum efficiencies exceeding 100%.

Luther, J. M.; Semonin, O. E.; Beard, M. C.; Gao, J.; Nozik, A. J.

2012-01-01

264

Harmonic multiplication using resonant tunneling  

NASA Technical Reports Server (NTRS)

This paper demonstrates the use of resonant-tunneling diodes as varistors for harmonic multiplication. It is shown that efficient odd-harmonic conversion is possible and that even harmonics do not appear because of the antisymmetry of the current-voltage (I-V) curve. It is also shown that, with the proper choice of resonant-tunneling structure and pump amplitude, most of the harmonic output power can be confined to a single odd-harmonic frequency. Fifth-harmonic multiplication was demonstrated with an output at 21.75 GHz and a power conversion efficiency of 0.5 percent, and a fifth-harmonic efficiency of 2.7 percent was achieved in a circuit simulation using an improved I-V curve.

Sollner, T. C. L. G.; Brown, E. R.; Goodhue, W. D.; Correa, C. A.

1988-01-01

265

Chordomas Involving Multiple Neuraxial Bones  

PubMed Central

We present a patient with multifocal symptomatic osseous chordomas having unusual growth patterns with review of the pertinent literature. The patient was 62-year-old male and had multiple osseous chordomas located in sacral, thoracic, and paraclival jugular foramen areas. There was no metastasis in other organs. All affected sites were osseous. The multicentric chordomas are extremely rare. This case could be considered as a chordoma involving multiple neuraxial bones. But, the possibility of multicentricity could also be thought. In such cases radical resection should be performed for each lesion at the initial diagnosis. If complete surgical resections are infeasible or impossible, preoperative or postoperative radiation therapy should be planned for the highest possibility of successful treatment. PMID:19242569

Lim, Jae Joon; Cho, Ki Hong; Yoon, Do Heum; Kim, Se Hoon

2009-01-01

266

Remyelinating strategies in multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disorder of the CNS characterized by infiltration of immune cells and progressive damage to myelin sheaths and neurons. In recent years, the importance of the neuronal compartment in the early pathology of multiple sclerosis has become increasingly clear. Direct axonal damage within the early stages of inflammation as well as neuronal injury as a result of chronic demyelination are essential factors for the development of long-term disability in patients. Viewing MS as both inflammatory and neurodegenerative has significant implications for treatment, with remyelination of denuded axons to protect neurons from damage being necessary in addition to controlling inflammation. Here, we review recent molecular insights into key molecules and pathways controlling the differentiation of oligodendrocyte progenitor cells and the regenerative process of remyelination in MS and discuss the resulting options regarding remyelinating treatment strategies. PMID:25331418

Luessi, Felix; Kuhlmann, Tanja; Zipp, Frauke

2014-11-01

267

Matrix Multiplication via Arithmetic Progressions  

Microsoft Academic Search

We present a new method for accelerating matrix multiplication asymptotically. This work builds on recent ideas of Volker Strassen,by using a basic trilinear form which is not a matrix product. We make novel use of the Salem-Spencer Theorem, which gives a fairly dense set of integers with no three-term arithmetic progression. Our resulting matrix exponent is 2.376.

Don Coppersmith; Shmuel Winograd

1990-01-01

268

Melanoma Multiple Primary Rules Matrix  

Cancer.gov

Cutaneous Melanoma Multiple Primary Rules – Matrix C440 – C449 (Excludes melanoma of any other site) * P r e p ar e o n e abs tr a c t. U s e t h e hi s t o lo g y c o di ng r u le s t o as s i gn th e ap pr o p r iat e h is to lo

269

Management of multiple valve disease.  

PubMed

Multivalvular heart disease is not an uncommon situation, but the paucity of data for each specific situation does not allow the proposal of a standardised, evidence-based management strategy. This paper aims at reviewing the available evidence on the management of multivalvular disease, taking into account the interactions between different valve lesions, the diagnostic pitfalls and the strategies that should be considered in the presence of multiple valvular disease. PMID:21156677

Unger, Philippe; Rosenhek, Raphael; Dedobbeleer, Chantal; Berrebi, Alain; Lancellotti, Patrizio

2011-02-01

270

PERSONS WITH MULTIPLE PERSONALITY DISORDER  

Microsoft Academic Search

In the past, Internal Self 1lelpers (ISM) of persons with multiple personality rlisorrler OWPI)) have been deseriberl by rr )7mill Humber of therapists. ii is .studV Iwo\\/ens the base ala I inaton relating to ISHs. Forty respondents who collectively had been therapists fur-rr totrtl of 690 i11P1) patients participated in the snarly. 77re findings of this study suti g ges

M. Ann Adams; Ann Adams; M. N. Sc

1989-01-01

271

Sleep Problems in Multiple Sclerosis  

Microsoft Academic Search

Twenty-eight consecutive patients with multiple sclerosis (MS) were clinically evaluated to determine the presence of sleep-related disorders. There were 12 males and 16 females aged between 22 and 67 with disability ranging between 1.5 and 8.5 on Kurtzke extended disability status score (EDSS). Fifteen patients (54%) reported sleep-related problems. These included difficulties initiating sleep and\\/or frequent awakenings due to spasms

N. Tachibana; R. S. Howard; N. P. Hirsch; D. H. Miller; I. F. Moseley; D. Fish

1994-01-01

272

Bone health in multiple sclerosis  

Microsoft Academic Search

People who are disabled with multiple sclerosis (MS) may be at increased risk of osteoporosis. This review discusses issues\\u000a relevant to bone health in MS and makes practical recommendations regarding prevention and screening for osteoporosis and\\u000a fracture risk in MS. A search of the literature up until 5 April 2011 was performed using key search terms, and articles pertinent\\u000a to

J. C. Gibson; G. D. Summers

273

Protocol for multiple node network  

NASA Technical Reports Server (NTRS)

The invention is a multiple interconnected network of intelligent message-repeating remote nodes which employs an antibody recognition message termination process performed by all remote nodes and a remote node polling process performed by other nodes which are master units controlling remote nodes in respective zones of the network assigned to respective master nodes. Each remote node repeats only those messages originated in the local zone, to provide isolation among the master nodes.

Kirkham, Harold (Inventor)

1994-01-01

274

Protocol for multiple node network  

NASA Technical Reports Server (NTRS)

The invention is a multiple interconnected network of intelligent message-repeating remote nodes which employs an antibody recognition message termination process performed by all remote nodes and a remote node polling process performed by other nodes which are master units controlling remote nodes in respective zones of the network assigned to respective master nodes. Each remote node repeats only those messages originated in the local zone, to provide isolation among the master nodes.

Kirkham, Harold (Inventor)

1995-01-01

275

Kidney Multiple Primary Rules Matrix  

Cancer.gov

Kidney Multiple Primary Rules – Matrix C649 (Excludes lymphoma and leukemia M9590 – 9989 and Kaposi sarcoma M9140) * P r e p ar e o n e abs tr a c t. U s e t h e hi s t o lo g y c o di ng r u le s t o as s i gn th e ap pr o p r iat

276

Colon Multiple Primary Rules Matrix  

Cancer.gov

Colon Multiple Primary Rules – Matrix C180-C189 (Excludes lymphoma and leukemia M9590 – 9989 and Kaposi sarcoma M9140) * P r e p ar e o n e abs tr a c t. U s e t h e hi s t o lo g y c o di ng r u le s t o as s i gn th e ap pr o p

277

CHARGED PARTICLE MULTIPLICITIES AT BRAHMS.  

SciTech Connect

This report presents the measurement of charged particle multiplicity densities dN/d{eta} in ultrarelativistic heavy ion collisions as function of {eta} and the centrality of the collisions. This distributions were extracted from data collected by the BRAHMS collaboration during the first RHK run with gold ions at {radical}s{sub NN} = 130A {center_dot} GeV. The analysis method is described and, results are compared to some model predictions.

DEBBE, R., FOR THE BRAHMS COLLABORATION

2001-07-30

278

Distributive Property Matrix Multiplication (1)  

NSDL National Science Digital Library

This interactive Java learning tool allows a teacher to demonstrate and explore the distributive property with expressions in the factored form (a + b) (c + d) using a matrix multiplication method with students. Sliders determine the number values from 20 to -20 with increments of one-tenth. Check boxes show or hide the factored form, starting matrix values, matrix, products in the matrix, and solution.

Peter Tierney-Fife

2009-02-20

279

FRACTIONAL DYNAMICS AT MULTIPLE TIMES  

PubMed Central

A continuous time random walk (CTRW) imposes a random waiting time between random particle jumps. CTRW limit densities solve a fractional Fokker-Planck equation, but since the CTRW limit is not Markovian, this is not sufficient to characterize the process. This paper applies continuum renewal theory to restore the Markov property on an expanded state space, and compute the joint CTRW limit density at multiple times. PMID:23378670

Meerschaert, Mark M.; Straka, Peter

2013-01-01

280

Multiple man-machine interfaces  

NASA Technical Reports Server (NTRS)

The multiple man machine interfaces inherent in military pilot training, their social implications, and the issue of possible negative feedback were explored. Modern technology has produced machines which can see, hear, and touch with greater accuracy and precision than human beings. Consequently, the military pilot is more a systems manager, often doing battle against a target he never sees. It is concluded that unquantifiable human activity requires motivation that is not intrinsic in a machine.

Stanton, L.; Cook, C. W.

1981-01-01

281

Multiple target laser ablation system  

DOEpatents

A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film.

Mashburn, Douglas N. (Knoxville, TN)

1996-01-01

282

FORESTRY 347 MULTIPLE RESOURCE SILVICULTURE  

E-print Network

FORESTRY 347 MULTIPLE RESOURCE SILVICULTURE Autumn 2008 Instructor: John Goodburn Office: Rm. 409 Science Complex Telephone: 243-4295 Email: goodburn@forestry.umt.edu Office hours: Mon. 3:00 - 5:00 pm.m. Rm. 301 Forestry Bldg. Lab/Field Work Wed or Thur. 2:10 - 6:00 p.m. In Field or Rm. 106 (W) & 206(H

Vonessen, Nikolaus

283

Interleave division multiple-access  

Microsoft Academic Search

This paper provides a comprehensive study of interleave-division multiple-access (IDMA) systems. The IDMA receiver principles for different modulation and channel conditions are outlined. A semi-analytical technique is developed based on the density evolution technique to estimate the bit-error-rate (BER) of the system. It provides a fast and relatively accurate method to predict the performance of the IDMA scheme. Simulation examples

Li Ping; Lihai Liu; Keying Y. Wu; W. K. Leung

2006-01-01

284

Sense-making and Multiplication  

NSDL National Science Digital Library

In this 14-minute video UK teacher Sally Hill uses patterns to help her students learn the multiples of four and understand how to apply that knowledge to more complex multi-digit problems. Head teacher Kate Frood discusses the school's guiding principles and her own style of leadership. The page includes a link to a pdf document summarizing K-4 Mental Math Strategies [cataloged separately].

2012-01-01

285

Paired-angle multiplicative compounding.  

PubMed

Ultrasound compounding is a method of combining multiple images from different angles in order to create a single image with improved resolution and reduced angular-dependent artifactual detail. Compounding methods traditionally calculate each pixel in the compound image as a simple functional relationship between pixel elements in the component image set. In order to achieve an even better resolution and further reduce angular-dependent artifacts, this paper investigates a new type of compounding we call paired angle multiplicative compounding (PAMC), in which compound images are produced by a summation of multiplied pairs of component images acquired at different angles. A PAMC image of a breast phantom demonstrates improved delineation ofmicrocalcifications in comparison to the mean operation. Images of the forearm are used to investigate larger angles of paired multiplication, the best improving contrast ratio (28%) and signal to noise ratio (24%) when compared to the mean method. The PAMC method is found to be similar to the MEM and median compounding operations, the largest difference being that it is better preserving contributions from normal incidence but at the expense of needing a larger angular range. PMID:18939612

Macione, James; Yang, Zhi; Fox, Martin

2008-04-01

286

Entropy content of multiplicity distributions  

NASA Astrophysics Data System (ADS)

We argue that the entropy S is an important variable to consider for multiparticle productions. A prediction of the width parameter 1//k of multiplicity distributions can be made at superhigh energies by extrapolating the entropy variable S, considered as a function of the average multiplicity Nmacr;. This is done explicitly for the negative binomial distributions and the Furry-Yule distributions, though the method is applicable to other distributions. We also argue that direct extrapolation in the variable 1//k is not advisable. Further evidence for SSZ scaling is given, and a power law for the average multiplicity N¯ as a function of the collision energy ?s is derived. It is a pleasure to thank Rudy Hwa and David Kiang for discussions and help. I am also grateful to Dr. V. Šimák and Dr. M. Šumbera for a correspondence pointing out a numerical error in the earlier version of this work. This work is supported in part by the Natural Science and Engineering Research Council of Canada and the Québec Department of Education.

Lam, C. S.

1989-02-01

287

Mediation Analysis with Multiple Mediators  

PubMed Central

Recent advances in the causal inference literature on mediation have extended traditional approaches to direct and indirect effects to settings that allow for interactions and non-linearities. In this paper, these approaches from causal inference are further extended to settings in which multiple mediators may be of interest. Two analytic approaches, one based on regression and one based on weighting are proposed to estimate the effect mediated through multiple mediators and the effects through other pathways. The approaches proposed here accommodate exposure-mediator interactions and, to a certain extent, mediator-mediator interactions as well. The methods handle binary or continuous mediators and binary, continuous or count outcomes. When the mediators affect one another, the strategy of trying to assess direct and indirect effects one mediator at a time will in general fail; the approach given in this paper can still be used. A characterization is moreover given as to when the sum of the mediated effects for multiple mediators considered separately will be equal to the mediated effect of all of the mediators considered jointly. The approach proposed in this paper is robust to unmeasured common causes of two or more mediators.

VanderWeele, T.J.; Vansteelandt, S.

2014-01-01

288

Venous thromboembolism in multiple myeloma.  

PubMed

As for other malignancies, multiple myeloma is associated with an increased risk of venous thromboembolism (VTE). The incidence of VTE is estimated as 8 to 22 per 1,000 person-years; risk factors can be patient related (advanced age, other risk factors shared with the general population), disease related, and treatment related. Disease-related risk factors can derive from the monoclonal component (rarely hyperviscosity or inhibition of natural anticoagulants) or hypercoagulability sustained by inflammatory cytokines (increased von Willebrand factor, factor VIII, fibrinogen levels, decreased protein S levels, acquired activated protein C resistance). The 1 to 2% baseline of incident VTE associated with conventional therapies as melphalan and prednisone is at least doubled by the use of doxorubicin or other chemotherapeutic agents. The VTE rate associated with thalidomide or lenalidomide as monotherapy is similar, whereas combination with high-dose dexamethasone or multiple chemotherapeutic agents induces a multiplicative effect on the VTE rate up to 25%. Low-molecular-weight heparin (LMWH), fixed low-dose warfarin, and aspirin are acceptable strategies for antithrombotic prophylaxis, reducing VTE to 5 to 8% in thalidomide-treated patients and 1 to 3% in lenalidomide-treated patients. LMWH shows an advantage in efficacy not statistically significant. Prophylaxis should be tailored considering individual risk factors for VTE, the stage of disease, the possible occurrence of thrombocytopenia, or renal insufficiency. PMID:24599441

De Stefano, Valerio; Za, Tommaso; Rossi, Elena

2014-04-01

289

Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop.  

PubMed Central

In vitro as well as in vivo observations have shown that IL6 plays a key role in the pathogenesis of multiple myeloma. Therefore we started a phase I/II dose escalating study with chimeric monoclonal anti-IL6 antibodies (cMab) in multiple myeloma (MM) patients resistant to second-line chemotherapy. Here we describe the pharmacological data as well as a new method for calculating the endogenous IL6 production. The cMab (CLB IL6/8; Kd: 6.25 x 10(-12) M) was given in two cycles of 14 daily infusions, starting on day 1 and day 28. Daily dose: 5 mg in patients 1-3, 10 mg in patients 4-6, and 20 mg in patients 7-9 (total dose 140, 280, and 560 mg of anti-IL6, respectively). Using the pharmacokinetic data of free IL6 and the binding characteristics of the cMab, the endogenous IL6 production could be calculated from day to day using a one-compartment open model. The median half-life time of this antibody was 17.6 d. No human antichimeric antibodies were induced. Pre-treatment median endogenous IL6 production in the MM patients was 60 micrograms/d (range 13.8-230; normal controls < 7 micrograms/d). During treatment with anti-IL6 cMabs, the endogenous IL6 production immediately decreased in all patients to below 3 micrograms/d and never reached the pre-treatment value during the treatment period, except in two patients who developed an active infection, resulting in an IL6 production of 128 and 1,208 micrograms/d, respectively. We concluded that in MM patients endogenous IL6 production is 2-30 times higher than in healthy individuals. The anti-IL6 cMab strongly suppress this endogenous IL6 production, probably by blocking a positive feed-back loop, but this cMab does not prevent infection-induced IL6 production. The chimeric anti-IL6 Mabs have a long half-life time, a low immunogenicity, and are able to block IL6-dependent processes in vivo. PMID:8823310

van Zaanen, H C; Koopmans, R P; Aarden, L A; Rensink, H J; Stouthard, J M; Warnaar, S O; Lokhorst, H M; van Oers, M H

1996-01-01

290

Modeling Multiple Causes of Carcinogenesis  

SciTech Connect

An array of epidemiological results and databases on test animal indicate that risk of cancer and atherosclerosis can be up- or down-regulated by diet through a range of 200%. Other factors contribute incrementally and include the natural terrestrial environment and various human activities that jointly produce complex exposures to endotoxin-producing microorganisms, ionizing radiations, and chemicals. Ordinary personal habits and simple physical irritants have been demonstrated to affect the immune response and risk of disease. There tends to be poor statistical correlation of long-term risk with single agent exposures incurred throughout working careers. However, Agency recommendations for control of hazardous exposures to humans has been substance-specific instead of contextually realistic even though there is consistent evidence for common mechanisms of toxicological and carcinogenic action. That behavior seems to be best explained by molecular stresses from cellular oxygen metabolism and phagocytosis of antigenic invasion as well as breakdown of normal metabolic compounds associated with homeostatic- and injury-related renewal of cells. There is continually mounting evidence that marrow stroma, comprised largely of monocyte-macrophages and fibroblasts, is important to phagocytic and cytokinetic response, but the complex action of the immune process is difficult to infer from first-principle logic or biomarkers of toxic injury. The many diverse database studies all seem to implicate two important processes, i.e., the univalent reduction of molecular oxygen and breakdown of aginuine, an amino acid, by hydrolysis or digestion of protein which is attendant to normal antigen-antibody action. This behavior indicates that protection guidelines and risk coefficients should be context dependent to include reference considerations of the composite action of parameters that mediate oxygen metabolism. A logic of this type permits the realistic common-scale modeling of multiple causes of carcinogenesis and shifts the risk-assessment logic to considerations of ?what dose does?? in contrast to the current process of the substance-specific question of ?what dose is?? Whether reactive oxygen is the proximate or contributing cause of disease or simply a better estimate of biologically effective dose, it has enormous advantages for improved risk- and policy-based decisions. Various estimates of immune system modulation will be given based on radiobiology.

Jones, T.D.

1999-01-24

291

Multiple frequency printed slot and dipole antennas  

E-print Network

Multiple frequency antennas are becoming more and more important as the technology advances. Printed circuit antennas can be designed to achieve multiple frequency operation. The advantages like low cost, conformal and planar, and a possible...

Kolsrud, Arild

2012-06-07

292

42 CFR 102.45 - Multiple survivors.  

Code of Federal Regulations, 2010 CFR

...PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request...Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...

2010-10-01

293

42 CFR 102.45 - Multiple survivors.  

Code of Federal Regulations, 2011 CFR

...PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request...Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...

2011-10-01

294

Multiple aspect ranking for opinion analysis  

E-print Network

We address the problem of analyzing multiple related opinions in a text. For instance, in a restaurant review such opinions may include food, ambiance and service. We formulate this task as a multiple aspect ranking problem, ...

Snyder, Benjamin, Ph. D. Massachusetts Institute of Technology

2007-01-01

295

46 CFR 129.323 - Multiple generators.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Multiple generators. 129.323 Section 129.323 Shipping...Distribution Systems § 129.323 Multiple generators. If an OSV uses two or more generators to supply electricity for the...

2012-10-01

296

46 CFR 183.322 - Multiple generators.  

Code of Federal Regulations, 2010 CFR

... 2010-10-01 false Multiple generators. 183.322 Section 183.322 ...Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2010-10-01

297

46 CFR 183.322 - Multiple generators.  

Code of Federal Regulations, 2012 CFR

... 2012-10-01 false Multiple generators. 183.322 Section 183.322 ...Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2012-10-01

298

46 CFR 183.322 - Multiple generators.  

Code of Federal Regulations, 2011 CFR

... 2011-10-01 false Multiple generators. 183.322 Section 183.322 ...Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2011-10-01

299

46 CFR 183.322 - Multiple generators.  

Code of Federal Regulations, 2013 CFR

... 2013-10-01 false Multiple generators. 183.322 Section 183.322 ...Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2013-10-01

300

46 CFR 120.322 - Multiple generators.  

Code of Federal Regulations, 2013 CFR

... 2013-10-01 false Multiple generators. 120.322 Section 120.322 ...Distribution Systems § 120.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2013-10-01

301

46 CFR 120.322 - Multiple generators.  

Code of Federal Regulations, 2011 CFR

... 2011-10-01 false Multiple generators. 120.322 Section 120.322 ...Distribution Systems § 120.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2011-10-01

302

46 CFR 129.323 - Multiple generators.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Multiple generators. 129.323 Section 129.323 Shipping...Distribution Systems § 129.323 Multiple generators. If an OSV uses two or more generators to supply electricity for the...

2013-10-01

303

46 CFR 120.322 - Multiple generators.  

Code of Federal Regulations, 2012 CFR

... 2012-10-01 false Multiple generators. 120.322 Section 120.322 ...Distribution Systems § 120.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2012-10-01

304

46 CFR 129.323 - Multiple generators.  

Code of Federal Regulations, 2014 CFR

...2014-10-01 2014-10-01 false Multiple generators. 129.323 Section 129.323 Shipping...Distribution Systems § 129.323 Multiple generators. If an OSV uses two or more generators to supply electricity for the...

2014-10-01

305

46 CFR 120.322 - Multiple generators.  

Code of Federal Regulations, 2010 CFR

... 2010-10-01 false Multiple generators. 120.322 Section 120.322 ...Distribution Systems § 120.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2010-10-01

306

46 CFR 183.322 - Multiple generators.  

Code of Federal Regulations, 2014 CFR

... 2014-10-01 false Multiple generators. 183.322 Section 183.322 ...Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2014-10-01

307

46 CFR 120.322 - Multiple generators.  

Code of Federal Regulations, 2014 CFR

... 2014-10-01 false Multiple generators. 120.322 Section 120.322 ...Distribution Systems § 120.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2014-10-01

308

46 CFR 129.323 - Multiple generators.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false Multiple generators. 129.323 Section 129.323 Shipping...Distribution Systems § 129.323 Multiple generators. If an OSV uses two or more generators to supply electricity for the...

2010-10-01

309

46 CFR 129.323 - Multiple generators.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false Multiple generators. 129.323 Section 129.323 Shipping...Distribution Systems § 129.323 Multiple generators. If an OSV uses two or more generators to supply electricity for the...

2011-10-01

310

The multiple control of verbal behavior.  

PubMed

Amid the novel terms and original analyses in Skinner's Verbal Behavior, the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms convergent multiple control and divergent multiple control. We point out some implications for applied work and discuss examples of the role of multiple control in humor, poetry, problem solving, and recall. Joint control and conditional discrimination are discussed as special cases of multiple control. We suggest that multiple control is a useful analytic tool for interpreting virtually all complex behavior, and we consider the concepts of derived relations and naming as cases in point. PMID:22532752

Michael, Jack; Palmer, David C; Sundberg, Mark L

2011-01-01

311

All About Multiplication Exploring Equal Sets  

NSDL National Science Digital Library

Students explore the set model for multiplication. They find products using equal sets and present their results in a table. Next students apply their knowledge about multiplication in the creation of pictographs (from NCTM's Illuminations website).

Illuminations National Council of Teachers of Math

2009-03-17

312

The Multiple Control of Verbal Behavior  

PubMed Central

Amid the novel terms and original analyses in Skinner's Verbal Behavior, the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms convergent multiple control and divergent multiple control. We point out some implications for applied work and discuss examples of the role of multiple control in humor, poetry, problem solving, and recall. Joint control and conditional discrimination are discussed as special cases of multiple control. We suggest that multiple control is a useful analytic tool for interpreting virtually all complex behavior, and we consider the concepts of derived relations and naming as cases in point. PMID:22532752

Michael, Jack; Palmer, David C; Sundberg, Mark L

2011-01-01

313

Correlation of multiple sclerosis (MS) incidence trends with solar and geomagnetic indices: Time to revise the method of reporting MS epidemiological data  

PubMed Central

Background: Recently, we introduced solar related geomagnetic disturbances (GMD) as a potential environmental risk factor for multiple sclerosis (MS). The aim of this study was to test probable correlation between solar activities and GMD with long-term variations of MS incidence. Methods: After a systematic review, we studied the association betwee n alterations in the solar wind velocity (VSW) and planetary A index (AP, a GMD index) with MS incidence in Tehran and western Greece, during the 23rd solar cycle (1996–2008), by an ecological-correlational study. Results: We found moderate to strong correlations among MS incidence of Tehran with VSW (rS = 0.665, P = 0.013), with 1 year delay, and also with AP (rS = 0.864, P = 0.001) with 2 year delay. There were very strong correlations among MS incidence data of Greece with VSW (r = 0.906, P < 0.001) and with AP (r = 0.844, P = 0.001), both with 1 year lag. Conclusion: It is the first time that a hypothesis has introduced an environmental factor that may describe MS incidence alterations; however, it should be reminded that correlation does not mean necessarily the existence of a causal relationship. Important message of these findings for researchers is to provide MS incidence reports with higher resolution for consecutive years, based on the time of disease onset and relapses, not just the time of diagnosis. Then, it would be possible to further investigate the validity of GMD hypothesis or any other probable environmental risk factors. PMID:25295148

Abdollahi, Fahimeh; Sajedi, Seyed Aidin

2014-01-01

314

Hypnosis creates multiple personality: Myth or reality?  

Microsoft Academic Search

Since before the turn of the century, multiple personality has been associated with hysteria and hypnosis. The myth that hypnosis can create multiple personality is examined in this paper by reviewing studies that have suggested or implied a casual link between hypnosis and multiple personality. While it is possible that personality fragments can appear under hypnosis, there is no evidence

Bennett G. Braun

1984-01-01

315

ORIGINAL CONTRIBUTION Modification of Multiple Sclerosis Phenotypes  

E-print Network

ORIGINAL CONTRIBUTION Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. Oksenberg, PhD Background: In those with multiple sclerosis (MS), Afri- can American individuals have a more ancestry at HLA correlated with dis- ability as measured by the Multiple Sclerosis Severity Score (P .001

Reich, David

316

Multiple diffusion and multicultural aggregate social systems  

Microsoft Academic Search

Extends the diffusion of innovations paradigm to today’s pluralistic marketplace by introducing the concept of multiple diffusion, whereby an innovation diffuses in multiple sub-social systems, each with a distinct pattern of adoption, that together comprise the aggregate diffusion pattern for a given society. Identifies variables that affect the multiple diffusion process, presents propositions related to them, and discusses implications of

Madhavan Parthasarathy; Sunkyu Jun; Robert A. Mittelstaedt

1997-01-01

317

Functional Multiple-Set Canonical Correlation Analysis  

ERIC Educational Resources Information Center

We propose functional multiple-set canonical correlation analysis for exploring associations among multiple sets of functions. The proposed method includes functional canonical correlation analysis as a special case when only two sets of functions are considered. As in classical multiple-set canonical correlation analysis, computationally, the…

Hwang, Heungsun; Jung, Kwanghee; Takane, Yoshio; Woodward, Todd S.

2012-01-01

318

The Method of Multiple Working Hypotheses  

NSDL National Science Digital Library

This essay describes the problems that can develop while working with multiple hypotheses and presents ideas for solving these problems. Topics discussed include premature theory development, the lingering of ruling theories, developing multiple working hypotheses, vacillation, and the potential drawbacks of working with multiple hypotheses.

Chamberlin, T. C.; Excellence, Access

319

The Multiple Control of Verbal Behavior  

ERIC Educational Resources Information Center

Amid the novel terms and original analyses in Skinner's "Verbal Behavior", the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms "convergent…

Michael, Jack; Palmer, David C.; Sundberg, Mark L.

2011-01-01

320

Lattice Multiplication in a Preservice Classroom  

ERIC Educational Resources Information Center

This article discusses the algorithm for multiplication that is referred to as lattice multiplication. Evidence of how the author's preservice students' conceptual understanding of the algorithm grew through the semester is given. In addition, the author extends the conceptualization of the algorithm from the multiplication of whole numbers to the…

Nugent, Patricia M.

2007-01-01

321

Multiple-Beam Communications Antenna  

NASA Technical Reports Server (NTRS)

System has both fixed-spot and scanning coverage. Advanced offset-fed spacecraft antenna systems operating in 30/20 GHz frequency bands developed to provide multiple-radiating fixed-spot and regional-coverage scanning beams for use on communications satellites. Operating at higher frequencies, provides alternate frequency bands for expansion of existing satellite services and achieving frequency reuse capability for conservation of frequency spectrum. 20-GHz transmitting antenna is offset-fed, dual-reflector configuration. 30-GHz receiving antenna has orthogonal polarized feeds, hyperbolic reflectors, and two subreflectors.

Myhre, R. W.; Roberts, T. E.; Wong, W. C.

1989-01-01

322

Multiple single-centered attractors  

NASA Astrophysics Data System (ADS)

In this paper we study spherically symmetric single-centered attractors in supergravity in four dimensions. The attractor points are obtained by extremising the effective black hole potential in the moduli space. Both supersymmetric as well as non-supersymmetric attractors exist in mutually exclusive domains of the charge lattice. We construct axion free supersymmetric as well as non-supersymmetric multiple attractors in a simple two parameter model. We further obtain explicit examples of two distinct non-supersymmetric attractors in type IIA string theory compactified on K3 × T 2 carrying D0 - D4 - D6 charges. We compute the entropy of these attractors and analyse their stability in detail.

Dominic, Pramod; Mandal, Taniya; Tripathy, Prasanta K.

2014-12-01

323

Multiple sclerosis : A multielement survey.  

PubMed

Levels of 35 elements have been measured in whole blood and ultrasonically washed scalp hair from multiple sclerosis patients and matched control subjects from Oxford, England. Among the significant differences found, the low levels of vanadium and the high levels of barium in the patients were most marked and consistent. Although the etiological significance of the observations is unknown, the low hair-vanadium levels are in qualitative agreement with a previous Canadian report. Hair- and blood-lead levels in the patients and the controls were virtually identical. PMID:24259117

Ward, N I; Bryce-Smith, D; Minski, M; Matthews, W B

1985-04-01

324

Recirculation in multiple wave conversions  

SciTech Connect

A one-dimensional multiple wave-conversion model is constructed that allows energy recirculation in ray phase space. Using a modular eikonal approach, the connection coefficients for this model are calculated by ray phase-space methods. Analytical results (confirmed numerically) show that all connection coefficients exhibit interference effects that depend on an interference phase, calculated from the coupling constants and the area enclosed by the intersecting rays. This conceptual model, which focuses on the topology of intersecting rays in phase space, is used to investigate how mode conversion between primary and secondary waves is modified by the presence of a tertiary wave.

Kaufman, A. N.; Brizard, A.J.; Kaufman, A.N.; Tracy, E.R.

2008-07-30

325

Multiple channel programmable coincidence counter  

DOEpatents

A programmable digital coincidence counter having multiple channels and featuring minimal dead time. Neutron detectors supply electrical pulses to a synchronizing circuit which in turn inputs derandomized pulses to an adding circuit. A random access memory circuit connected as a programmable length shift register receives and shifts the sum of the pulses, and outputs to a serializer. A counter is input by the adding circuit and downcounted by the seralizer, one pulse at a time. The decoded contents of the counter after each decrement is output to scalers.

Arnone, Gaetano J. (Los Alamos, NM)

1990-01-01

326

Multiple piece turbine rotor blade  

SciTech Connect

A multiple piece turbine rotor blade with a shell having an airfoil shape and secured between a spar and a platform with the spar including a tip end piece. a snap ring fits around the spar and abuts against the spar tip end piece on a top side and abuts against a shell on the bottom side so that the centrifugal loads from the shell is passed through the snap ring and into the spar and not through a tip cap dovetail slot and projection structure.

Jones, Russell B; Fedock, John A

2013-05-21

327

Coordination of multiple robot arms  

NASA Technical Reports Server (NTRS)

Kinematic resolved-rate control from one robot arm is extended to the coordinated control of multiple robot arms in the movement of an object. The structure supports the general movement of one axis system (moving reference frame) with respect to another axis system (control reference frame) by one or more robot arms. The grippers of the robot arms do not have to be parallel or at any pre-disposed positions on the object. For multiarm control, the operator chooses the same moving and control reference frames for each of the robot arms. Consequently, each arm then moves as though it were carrying out the commanded motions by itself.

Barker, L. K.; Soloway, D.

1987-01-01

328

Recirculation in multiple wave conversions  

SciTech Connect

A one-dimensional multiple wave-conversion model is constructed that allows energy recirculation in ray phase space. Using a modular eikonal approach, the connection coefficients for this model are calculated by ray phase-space methods. Analytical results (confirmed numerically) show that all connection coefficients exhibit interference effects that depend on an interference phase, calculated from the coupling constants and the area enclosed by the intersecting rays. This conceptual model, which focuses on the topology of intersecting rays in phase space, is used to investigate how mode conversion between primary and secondary waves is modified by the presence of a tertiary wave.

Brizard, A. J. [Department of Chemistry and Physics, Saint Michael's College, Colchester, Vermont 05439 (United States); Kaufman, A. N. [Department of Physics and Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720 (United States); Tracy, E. R. [Department of Physics, College of William and Mary, Williamsburg, Virginia 23187-8795 (United States)

2008-08-15

329

Sleep disorders in multiple sclerosis.  

PubMed

Sleep disorders are pervasive in patients with multiple sclerosis (MS) although clinically underrecognized by most physicians. The most common sleep disorders seen in patients with MS include insomnia, nocturnal movement disorders, sleep-disordered breathing, narcolepsy, and rapid eye movement sleep behavior disorder. Factors that influence the quality of sleep in this patient population include pain, nocturia, depression, medication effect, location of lesions, and disease severity. Disrupted sleep has the potential to cause daytime somnolence, increased fatigue, and nonrefreshing sleep, and it may be associated with dangerous respiratory events. Awareness and treatment of these conditions is vital to improving health and quality of life in patients with MS. PMID:15798938

Fleming, W Elon; Pollak, Charles P

2005-03-01

330

Ermakov systems with multiplicative noise  

NASA Astrophysics Data System (ADS)

Using the Euler-Maruyama numerical method, we present calculations of the Ermakov-Lewis invariant and the dynamic, geometric, and total phases for several cases of stochastic parametric oscillators, including the simplest case of the stochastic harmonic oscillator. The results are compared with the corresponding numerical noiseless cases to evaluate the effect of the noise. Besides, the noiseless cases are analytic and their analytic solutions are briefly presented. The Ermakov-Lewis invariant is not affected by the multiplicative noise in the three particular examples presented in this work, whereas there is a shift effect in the case of the phases.

Cervantes-López, E.; Espinoza, P. B.; Gallegos, A.; Rosu, H. C.

2014-05-01

331

Smart card multiple function badge  

SciTech Connect

Smart cards are credit card-sized computers with integrated data storage, an operating system to manage the data, and built-in security features that protect the data. They are used to distribute information to remote sites, providing the same or greater reliability, data integrity, and information security than a network system. However, smart cards may provide greater functionality at a lower cost than network systems. The US Department of Energy Hanford Site is developing the smart card to be used as a multiple function identification badge that will service various data management requirements on the Site. This paper discusses smart card technology and the proposed Hanford Site applications.

Nelson, R.A.

1993-06-01

332

Palmprint authentication using multiple classifiers  

NASA Astrophysics Data System (ADS)

This paper investigates the performance improvement for palmprint authentication using multiple classifiers. The proposed methods on personal authentication using palmprints can be divided into three categories; appearance- , line -, and texture-based. A combination of these approaches can be used to achieve higher performance. We propose to simultaneously extract palmprint features from PCA, Line detectors and Gabor-filters and combine their corresponding matching scores. This paper also investigates the comparative performance of simple combination rules and the hybrid fusion strategy to achieve performance improvement. Our experimental results on the database of 100 users demonstrate the usefulness of such approach over those based on individual classifiers.

Kumar, Ajay; Zhang, David

2004-08-01

333

Multiple protocol fluorometer and method  

DOEpatents

A multiple protocol fluorometer measures photosynthetic parameters of phytoplankton and higher plants using actively stimulated fluorescence protocols. The measured parameters include spectrally-resolved functional and optical absorption cross sections of PSII, extent of energy transfer between reaction centers of PSII, F.sub.0 (minimal), F.sub.m (maximal) and F.sub.v (variable) components of PSII fluorescence, photochemical and non-photochemical quenching, size of the plastoquinone (PQ) pool, and the kinetics of electron transport between Q.sub.a and PQ pool and between PQ pool and PSI. The multiple protocol fluorometer, in one embodiment, is equipped with an excitation source having a controlled spectral output range between 420 nm and 555 nm and capable of generating flashlets having a duration of 0.125-32 .mu.s, an interval between 0.5 .mu.s and 2 seconds, and peak optical power of up to 2 W/cm.sup.2. The excitation source is also capable of generating, simultaneous with the flashlets, a controlled continuous, background illumination.

Kolber, Zbigniew S. (Shoreham, NY); Falkowski, Paul G. (Stony Brook, NY)

2000-09-19

334

Multiple sclerosis and oral care.  

PubMed

Multiple sclerosis is a complex neurological condition affecting sensory and motor nerve transmission. Its progression and symptoms are unpredictable and vary from person to person as well as over time. Common early symptoms include visual disturbances, facial pain or trigeminal neuralgia and paraesthesia or numbness of feet, legs, hands and arms. These, plus symptoms of spasticity, spasms, tremor, fatigue, depression and progressive disability, impact on the individual's ability to maintain oral health, cope with dental treatment and access dental services. Also, many of the medications used in the symptomatic management of the condition have the potential to cause dry mouth and associated oral disease. There is no cure for multiple sclerosis, and treatment focuses on prevention of disability and maintenance of quality of life. Increasingly a multi-disciplinary team approach is used where the individual, if appropriate his/her carer, and the specialist nurse are key figures. The dental team plays an essential role in ensuring that oral health impacts positively on general health. PMID:12222018

Fiske, Janice; Griffiths, Janet; Thompson, Shelagh

2002-01-01

335

Multiple channel data acquisition system  

DOEpatents

A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler. 25 figs.

Crawley, H.B.; Rosenberg, E.I.; Meyer, W.T.; Gorbics, M.S.; Thomas, W.D.; McKay, R.L.; Homer, J.F. Jr.

1990-05-22

336

Automatic Tracking Of Multiple Objects  

NASA Astrophysics Data System (ADS)

We are developing a computer vision system to automatically detect and track human motion across the international border between the United States and Mexico. Fundamental requirements are that the system work in real time under varying environmental conditions with relatively inexpensive hardware. The work we describe is applicable to a wide range of multiple object tracking problems. This paper describes the algorithm we have developed to detect and track moving objects. The algorithm is based on the notion of path coherence. However, the algorithm presented there is not suitable for our application because it requires noise free images, all trajectories must be present from the first through last images, and it requires multiple passes throught the trajectory points as each new image is acquired. This procedure is not acceptable for real time applications. We have previously reported on the front end of our system which takes video images and determines the areas which represent changing objects'. Thus the input to the tracking portion of the system consists of a binary image representing the changing pixels. In this paper we present a detailed description of the tracking algorithm, its implementation in Smalltalk-80, and samples of its operation. We also discuss system performance as a function of trajectory complexity and image noise level.

Bernat, Andrew P.; Riter, Stephen

1989-03-01

337

Multiple pure tone noise prediction  

NASA Astrophysics Data System (ADS)

This paper presents a fully numerical method for predicting multiple pure tones, also known as “Buzzsaw” noise. It consists of three steps that account for noise source generation, nonlinear acoustic propagation with hard as well as lined walls inside the nacelle, and linear acoustic propagation outside the engine. Noise generation is modeled by steady, part-annulus computational fluid dynamics (CFD) simulations. A linear superposition algorithm is used to construct full-annulus shock/pressure pattern just upstream of the fan from part-annulus CFD results. Nonlinear wave propagation is carried out inside the duct using a pseudo-two-dimensional solution of Burgers' equation. Scattering from nacelle lip as well as radiation to farfield is performed using the commercial solver ACTRAN/TM. The proposed prediction process is verified by comparing against full-annulus CFD simulations as well as against static engine test data for a typical high bypass ratio aircraft engine with hardwall as well as lined inlets. Comparisons are drawn against nacelle unsteady pressure transducer measurements at two axial locations as well as against near- and far-field microphone array measurements outside the duct. This is the first fully numerical approach (no experimental or empirical input is required) to predict multiple pure tone noise generation, in-duct propagation and far-field radiation. It uses measured blade coordinates to calculate MPT noise.

Han, Fei; Sharma, Anupam; Paliath, Umesh; Shieh, Chingwei

2014-12-01

338

Multiple channel data acquisition system  

DOEpatents

A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler.

Crawley, H. Bert (Ames, IA); Rosenberg, Eli I. (Ames, IA); Meyer, W. Thomas (Ames, IA); Gorbics, Mark S. (Ames, IA); Thomas, William D. (Boone, IA); McKay, Roy L. (Ames, IA); Homer, Jr., John F. (Ames, IA)

1990-05-22

339

Possible Evidence for Enhanced Seasonality During the Little Ice Age Indicated by Multiple Isotopes from Kepler Lake, South-Central Alaska  

NASA Astrophysics Data System (ADS)

We present multiple-proxy data from two short cores (85 cm and 101 cm) from Kepler Lake, an evaporation- insensitive, groundwater-fed marl lake in South-Central Alaska to reconstruct climate and environmental changes in the recent centuries. The proxies used include calcite C and O isotopes, organic matter (OM) C and N isotopes, and loss on ignition (LOI) analysis. Two cores can be visually correlated based upon LOI results. A 600 year chronology was established based on 3 calibrated AMS 14C dates of terrestrial macrofossils and 210Pb analysis. ?18OVPDB values of inorganic calcite range from - 17.0‰ to -15.7‰, with the highest values between 1470 and 1840 AD during the Little Ice Age (LIA). The relatively high ?18O values during the cold LIA contrast with the conventional temperature interpretation of O isotopes. Therefore, the isotopic shifts around the LIA were likely caused by a shift in atmospheric circulation. A weakening of the wintertime Aleutian Low pressure system residing over the Gulf of Alaska would result in enriched 18O in precipitation as well as a colder winter climate in SC Alaska. During the LIA period CaCO3 contents were elevated by ~15% to >80%. Calcite precipitation in freshwater lakes is primarily a function of summer temperature; we propose that the LIA in SC Alaska represents a period of colder winters and warmer summers. This interpretation is also supported by C isotopes, reflecting aquatic productivity. Both ?13C OM and ?13Ccalcite (relative to VPDB) exhibit relatively high values at 1600 to 1840 AD, after which ?13COM remains constant throughout the rest of the record and ?13Ccalcite declines after the LIA. The delayed increase in ?13C of OM and calcites at 1600 AD may reflect the differential responses of calcite precipitation and aquatic productivity. The negative shift of ~1‰ in ?18O in the 1840s has also been documented in ice cores from Mt. Logan and in marl lake sediments from the southern Yukon, suggesting a broad-scale shift in atmospheric circulation at the end of the LIA. The enhanced seasonality during the LIA may explain some complex moisture and temperature changes as observed from glaciers, lakes and tree-ring records in the region. We speculate that these shifts during and after the LIA may be basin-wide events in the Pacific Ocean.

Gonyo, A.; Yu, Z.; Bebout, G.

2008-12-01

340

Multiple Sclerosis Society (Grant Tracker) Multiple Sclerosis Society (Grant Tracker) applicant guide June 2012 Page 1  

E-print Network

Multiple Sclerosis Society (Grant Tracker) Multiple Sclerosis Society (Grant Tracker) applicant guide June 2012 Page 1 2012 INTERNAL USER GUIDE A Guide to the Multiple Sclerosis Society Grant Tracker application system A Quick Guide for applicants applying for funding from the MS Society Multiple Sclerosis

341

Interacting Multiple Model Kalman Filters (IMMKF) Interacting Multiple Model Kalman Filters  

E-print Network

Interacting Multiple Model Kalman Filters (IMMKF) Interacting Multiple Model Kalman Filters (IMMKF R.Q.A. Santana Interacting Multiple Model Kalman Filters (IMMKF) #12;Interacting Multiple Model Kalman Filters (IMMKF) Sumário 1 Introdução Abordagens de múltiplos modelos Introdução ao Interacting

Williams, Brian C.

342

DEFLATED GMRES FOR SYSTEMS WITH MULTIPLE SHIFTS AND MULTIPLE RIGHT-HAND SIDES  

E-print Network

DEFLATED GMRES FOR SYSTEMS WITH MULTIPLE SHIFTS AND MULTIPLE RIGHT-HAND SIDES DEAN DARNELL, RONALD of nonsymmetric linear equations, possibly also with multiple right-hand sides. First, for a single right-hand be applied to multiply shifted systems. In quantum chromodynamics, it is common to have multiple right-hand

Morgan, Ron

343

Inverse scattering series for multiple attenuation: An example with surface and internal multiples  

SciTech Connect

A multiple attenuation method derived from an inverse scattering series is described. The inversion series approach allows a separation of multiple attenuation subseries from the full series. The surface multiple attenuation subseries was described and illustrated in Carvalho et al. (1991, 1992). The internal multiple attenuation method consists of selecting the parts of the odd terms that are associated with removing only multiply reflected energy. The method, for both types of multiples, is multidimensional and does not rely on periodicity or differential moveout, nor does it require a model of the reflectors generating the multiples. An example with internal and surface multiples will be presented.

Araujo, F.V. [PPPG/Federal Univ. of Bahia, Salvador (Brazil); Weglein, A.B. [Schlumberger Cambridge Research (United Kingdom); Carvalho, P.M. [Petrobras SA, Rio de Janeiro (Brazil); Stolt, R.H.

1994-12-31

344

Clustering of multiple sclerosis in Galion, Ohio, 1982-1985  

SciTech Connect

Epidemiologic evidence indicates that the outbreak of 30-40 cases of multiple sclerosis and other demyelinating syndromes in Galion, Ohio, USA, during 1982-1985 was related to an excess concentration of heavy-metal wastes, especially of cadmium and chromium in sewage and river water. Both multiple sclerosis and myasthenia gravis were diagnosed by board-certified neurologists.

Ingalls, T.H. (Boston Univ. School of Medicine, MA (USA))

1989-09-01

345

Students' Difficulties With Multiple Representations in Introductory Mechanics  

ERIC Educational Resources Information Center

Research in physics education indicates that the use of multiple representations in teaching and learning helps students become better problem-solvers. We report on a study to investigate students' difficulties in solving mechanics problems presented in multiple representations. We conducted teaching/learning interviews with 20 students in a…

Nguyen, Dong-Hai; Rebello, N. Sanjay

2011-01-01

346

Multiple Trajectories of Successful Aging of Older and Younger Cohorts  

ERIC Educational Resources Information Center

Purpose: The purpose of this study was to apply group-based trajectory analysis to identify multiple successful aging trajectories by multiple indicators and to examine the factors related to successful aging among the elderly population in Taiwan. Design and Methods: Nation-representative longitudinal data collected from 1993 to 2007 and…

Hsu, Hui-Chuan; Jones, Bobby L.

2012-01-01

347

Analysis of multiple-choice items.  

PubMed

This paper deals with scoring and analysis of multiple-choice exam questions. Data may be read by an optical mark reader scanner or from a file created by a system editor and stored in a format convenient to be analysed by a specially designed program 'MCQ'. In addition the data file created can be linked with the package SPSSx for pertinent statistical methods or SPSS Graphics for illustration of score and item distributions. The MCQ program comprises: (1) scoring; (2) item analysis: difficulty and discrimination indices; (3) testing the goodness of alternatives attached to each question. The method is applicable to multiple-choice questions with 4.5 greater than 5; true/false and combined exam questions. The method should prove useful for instructors to build up a balanced discriminant questions bank. PMID:1873997

Moussa, M A; Ouda, B A; Nemeth, A

1991-04-01

348

Multiple-stage integrating accelerometer  

DOEpatents

An accelerometer assembly is provided for use in activating a switch in response to multiple acceleration pulses in series. The accelerometer includes a housing forming a chamber. An inertial mass or piston is slidably disposed in the chamber and spring biased toward a first or reset position. A damping system is also provided to damp piston movement in response to first and subsequent acceleration pulses. Additionally, a cam, including a Z-shaped slot, and cooperating follower pin slidably received therein are mounted to the piston and the housing. The middle or cross-over leg of the Z-shaped slot cooperates with the follower pin to block or limit piston movement and prevent switch activation in response to a lone acceleration pulse. The switch of the assembly is only activated after two or more separate acceleration pulses are sensed and the piston reaches the end of the chamber opposite the reset position.

Devaney, Howard F. (Cedar Crest, NM)

1986-01-01

349

Multiple differential-aperture microscopy.  

SciTech Connect

Differential-aperture X-ray microscopy (DAXM) is a powerful approach to 3D tomography with particular relevance to X-ray microdiffraction. With DAXM, scattering from submicron volumes can be resolved. However, the method is intrinsically a scanning technique where every resolved volume element (voxel) requires at least one area-detector readout. Previous applications of DAXM have used a single wire for knife-edge step profiling. Here, we demonstrate a way to accelerate DAXM measurements using multiple wires. A proof-of-principle experiment with a three-wire prototype showed that the speed of measurements can be tripled, but careful calibrations of wires will be required to maintain the spatial accuracy. In addition, related possibilities for accelerating measurements are briefly discussed.

Chung, J.-S.; Isa, S.; Greene, V.; Broadwater, O.; Liu, W.; Ice, G. E.; ORNL; Soongsil Univ.; South Carolina State Univ.

2007-01-01

350

Multiple-stage integrating accelerometer  

DOEpatents

An accelerometer assembly is provided for use in activating a switch in response to multiple acceleration pulses in series. The accelerometer includes a housing forming a chamber. An inertial mass or piston is slidably disposed in the chamber and spring biased toward a first or reset position. A damping system is also provided to damp piston movement in response to first and subsequent acceleration pulses. Additionally, a cam, including a Z-shaped slot, and cooperating follower pin slidably received therein are mounted to the piston and the housing. The middle or cross-over leg of the Z-shaped slot cooperates with the follower pin to block or limit piston movement and prevent switch activation in response to a lone acceleration pulse. The switch of the assembly is only activated after two or more separate acceleration pulses are sensed and the piston reaches the end of the chamber opposite the reset position.

Devaney, H.F.

1984-06-27

351

Multiple intraabdominal parasitic cystic teratomas.  

PubMed

We report an interesting case of multiple intraabdominal dermoids in a patient who had undergone an excision of ovarian dermoid cyst earlier and presented with recurrence of symptoms. She had masses all over the abdominal wall, omentum, and pouch of Douglas and a dermoid cyst in the ovary as well. It is generally believed that autoamputation and reimplantation of an ovarian dermoid cyst is the most common cause of omental teratomas. Abdominal pain is the main presenting symptom of these tumors, and on physical examination a mobile abdominal or pelvic mass is often found. Both ultrasonography with color-flow Doppler ultrasonography and computed tomography are helpful in the diagnosis of dermoid tumors, but the correct diagnosis of omental localization is extremely difficult. We removed all the masses laparoscopically. Literature search did not reveal such extensive parasitic dermoids in any patient. PMID:19896613

Sinha, Rakesh; Sundaram, Meenakshi; Lakhotia, Smita

2009-01-01

352

Vitamin D and multiple sclerosis  

PubMed Central

Multiple sclerosis (MS) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immune system is under the influence of vitamin D which as a modulator of immune response could play a role in autoimmune diseases including MS. Deficiency of vitamin D or variations in DNA sequence (polymorphism) of vitamin D receptor gene diminishes its optimal function on immune system that consequently could lead to increasing risk of MS. However, its role in development and modulating the course of MS is still under investigation. In this review we aimed to discuss the role of vitamin D in body, immune system and consequently altering the risk of MS. PMID:24800040

Harandi, Ali Amini; Pakdaman, Hossein; Sahraian, Mohammad Ali

2014-01-01

353

Multiple pathways regulate shoot branching  

PubMed Central

Shoot branching patterns result from the spatio-temporal regulation of axillary bud outgrowth. Numerous endogenous, developmental and environmental factors are integrated at the bud and plant levels to determine numbers of growing shoots. Multiple pathways that converge to common integrators are most probably involved. We propose several pathways involving not only the classical hormones auxin, cytokinins and strigolactones, but also other signals with a strong influence on shoot branching such as gibberellins, sugars or molecular actors of plant phase transition. We also deal with recent findings about the molecular mechanisms and the pathway involved in the response to shade as an example of an environmental signal controlling branching. We propose the TEOSINTE BRANCHED1, CYCLOIDEA, PCF transcription factor TB1/BRC1 and the polar auxin transport stream in the stem as possible integrators of these pathways. We finally discuss how modeling can help to represent this highly dynamic system by articulating knowledges and hypothesis and calculating the phenotype properties they imply.

Rameau, Catherine; Bertheloot, Jessica; Leduc, Nathalie; Andrieu, Bruno; Foucher, Fabrice; Sakr, Soulaiman

2015-01-01

354

Painful and involuntary Multiple Sclerosis  

PubMed Central

Importance of the field Pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions may occur in patients with multiple sclerosis (MS). Areas covered in the field In the present review we attempt to summarize the current knowledge on the impact that pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions have in patients with MS. What the reader will gain The current understanding on pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions and future research perspectives to expand the knowledge of this field. Take home message To effectively manage MS it is essential that these symptoms are recognised as early as possible and treated by a rehabilitative multidisciplinary approach, based on proven scientific evidence. PMID:21323633

Bagnato, Francesca; Centonze, Diego; Galgani, Simonetta; Grasso, Maria Grazia; Haggiag, Shalom; Strano, Stefano

2010-01-01

355

[The epidemiology of multiple myeloma].  

PubMed

We investigated epidemiology of multiple myeloma (MM), referring to recent papers. This article includes three points: 1) the progression rate of monoclonal gammopathy of undetermined significance (MGUS) to MM, 2) the effect of radiation to prevalence of MM, and 3) secondary malignancy after chemotherapy used to treat MM. The risk of progression from MGUS to MM is 1% per year. The researches of atomic bomb showed that there is no increase of risk of MM after radiation exposure. In contrast, studies investigating workers in nuclear power plants point out that radiation exposure over 50 mSv increases risk of MM. The incidence of secondary malignancy after chemotherapy used to treat MM was about 5%. This article will help to review recent researches about epidemiology of MM. PMID:25626296

Suzuki, Kenshi; Takahashi, Haruka

2015-01-01

356

Lightweight multiple output converter development  

NASA Technical Reports Server (NTRS)

A high frequency, multiple output power conditioner was developed and breadboarded using an eight-stage capacitor diode voltage multiplier to provide +1200 Vdc, and a three-stage for -350 Vdc. In addition, two rectifier bridges were capacitively coupled to the eight-stage multiplier to obtain 0.5 and 0.65 a dc constant current outputs referenced to +1200 Vdc. Total power was 120 watts, with an overall efficiency of 85 percent at the 80 kHz operating frequency. All outputs were regulated to three percent or better, with complete short circuit protection. The power conditioner component weight and efficiency were compared to the equivalent four outputs of the 10 kHz conditioner for the 8 cm ion engine. Weight reduction for the four outputs was 557 grams; extrapolated in the same ratio to all nine outputs, it would be 1100 to 1400 grams.

Kisch, J. J.; Martinelli, R. M.

1978-01-01

357

Moral enhancement requires multiple virtues.  

PubMed

Some of the debates around the concept of moral enhancement have focused on whether the improvement of a single trait, such as empathy or intelligence, would be a good in general, or in all circumstances. All virtue theories, however, both secular and religious, have articulated multiple virtues that temper and inform one another in the development of a mature moral character. The project of moral enhancement requires a reengagement with virtue ethics and contemporary moral psychology to develop an empirically grounded model of the virtues and a fuller model of character development. Each of these virtues may be manipulable with electronic, psychopharmaceutical, and genetic interventions. A set of interdependent virtues is proposed, along with some of the research pointing to ways such virtues could be enhanced. PMID:25473861

Hughes, James J

2015-01-01

358

The angular gyrus: multiple functions and multiple subdivisions.  

PubMed

There is considerable interest in the structural and functional properties of the angular gyrus (AG). Located in the posterior part of the inferior parietal lobule, the AG has been shown in numerous meta-analysis reviews to be consistently activated in a variety of tasks. This review discusses the involvement of the AG in semantic processing, word reading and comprehension, number processing, default mode network, memory retrieval, attention and spatial cognition, reasoning, and social cognition. This large functional neuroimaging literature depicts a major role for the AG in processing concepts rather than percepts when interfacing perception-to-recognition-to-action. More specifically, the AG emerges as a cross-modal hub where converging multisensory information is combined and integrated to comprehend and give sense to events, manipulate mental representations, solve familiar problems, and reorient attention to relevant information. In addition, this review discusses recent findings that point to the existence of multiple subdivisions in the AG. This spatial parcellation can serve as a framework for reporting AG activations with greater definition. This review also acknowledges that the role of the AG cannot comprehensibly be identified in isolation but needs to be understood in parallel with the influence from other regions. Several interesting questions that warrant further investigations are finally emphasized. PMID:22547530

Seghier, Mohamed L

2013-02-01

359

Improving Multiple Fault Diagnosability using Possible Conflicts  

NASA Technical Reports Server (NTRS)

Multiple fault diagnosis is a difficult problem for dynamic systems. Due to fault masking, compensation, and relative time of fault occurrence, multiple faults can manifest in many different ways as observable fault signature sequences. This decreases diagnosability of multiple faults, and therefore leads to a loss in effectiveness of the fault isolation step. We develop a qualitative, event-based, multiple fault isolation framework, and derive several notions of multiple fault diagnosability. We show that using Possible Conflicts, a model decomposition technique that decouples faults from residuals, we can significantly improve the diagnosability of multiple faults compared to an approach using a single global model. We demonstrate these concepts and provide results using a multi-tank system as a case study.

Daigle, Matthew J.; Bregon, Anibal; Biswas, Gautam; Koutsoukos, Xenofon; Pulido, Belarmino

2012-01-01

360

Evaluating multiple coordinated windows for programming workstations  

NASA Technical Reports Server (NTRS)

Programmers might benefit from larger screens with multiple windows or multiple screens, especially if convenient coordination among screens are arranged. Uses for multiple coordinated displays in a programmers workstation are explored. Initial efforts focus on the potential applications, a command language for coordinating the displays, and the psychological basis for effective utilization so as to avoid information overload. Subsequent efforts will be devoted to implementing the concepts and performing controlled psychologically oriented experiments to validate the hypotheses.

Shneiderman, B.; Grantham, C.; Norman, K.; Rogers, J.; Roussopoulos, N.

1983-01-01

361

Multiple acousto-optic q-switch  

DOEpatents

An improved dynamic moire interferometer comprised of a lasing medium providing a plurality of beams of coherent light, a multiple q-switch producing multiple trains of 100,000 or more pulses per second, a combining means collimating multiple trains of pulses into substantially a single train and directing beams to specimen gratings affixed to a test material, and a controller, triggering and sequencing the emission of the pulses with the occurrence and recording of a dynamic loading event.

Deason, Vance A. (Idaho Falls, ID)

1993-01-01

362

Familial Facial disfigurement in Multiple Familial Trichoepithelioma  

PubMed Central

Trichoepithelioma is an uncommon, benign hamartomatous tumor of the pilosebaceous follicle. Presenting as multiple papules and nodules on face and neck, they pose a significant cosmetic problem in affected individuals. Familial involvement of this dermatosis occurs in an autosomal dominant pattern, the locus being located on chromosome 9p21, which causes multiple facial lesions in family members and their kins. Here, we report a case of multiple familial trichoepithelioma causing considerable disfigurement of the face. PMID:24551711

Kataria, Usha; Agarwal, Deepti; Chhillar, Dinesh

2013-01-01

363

Children's Inventions for Multidigit Multiplication and Division.  

ERIC Educational Resources Information Center

Describes an informal research activity in which third grade students invent their own algorithms for multidigit multiplication and division. Discusses teaching implications and action research ideas. (ASK)

Caliandro, Christine Koller

2000-01-01

364

Multiplicative Expansion of Microvascular Network: Intussusceptive Angiogenesis  

Cancer.gov

Meetings & Events Home Agenda Speaker Biosketches Abstracts Logistics Contact Abstracts Multiplicative Expansion of Microvascular Network: Intussusceptive Angiogenesis Steven J. Mentzer, MD  [ View bio ] (Harvard Medical School, Boston,

365

Thalassemia - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Thalassemia - Multiple Languages Chinese - Simplified (????) Chinese - Traditional (????) Spanish (español) Chinese - Simplified (????) Thalassemia English ??????? - ???? (Chinese - Simplified) PDF Chinese Community ...

366

Algebraic Expressions - Number Line Model for Multiplication  

NSDL National Science Digital Library

This interactive Java learning tool allows a teacher to demonstrate and explore with students number line models for two simple variable expressions for multiplication. The first expression is a variable with an understood coefficient of one and the second is the multiplication of a variable by a coefficient. Sliders are used to select the value of the variable (-10 to 10) and the coefficient (0 to 10). Check boxes show or hide the algebraic expression, the expression with substitution, the notation shown for multiplication, the result, and a model for the multiplication, shown as jumps along a number line.

Maine, Edc I.

2010-08-26

367

Diabetes Medicines - Multiple Languages: MedlinePlus  

MedlinePLUS

... features on this page, please enable JavaScript. Diabetes Medicines - Multiple Languages Arabic (???????) Chinese - Simplified (????) Chinese - Traditional (????) French (français) Hindi (??????) Japanese (???) ...

368

Breathing Problems - Multiple Languages: MedlinePlus  

MedlinePLUS

... enable JavaScript. Breathing Problems - Multiple Languages French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) ... incitatif - français (French) Bilingual PDF Health Information Translations Hindi (??????) Incentive Spirometer ?????? (Hindi) Bilingual ...

369

Colonic Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

... Colonic Diseases - Multiple Languages Arabic (???????) French (français) Hindi (??????) Japanese (???) Korean (???) Russian (???????) ... baryté - français (French) Bilingual PDF Health Information Translations Hindi (??????) Barium Enema ?????? (Hindi) Bilingual ...

370

Dynamical modelling of coordinated multiple robot systems  

NASA Technical Reports Server (NTRS)

The state of the art in the modeling of the dynamics of coordinated multiple robot manipulators is summarized and various problems related to this subject are discussed. It is recognized that dynamics modeling is a component used in the design of controllers for multiple cooperating robots. As such, the discussion addresses some problems related to the control of multiple robots. The techniques used to date in the modeling of closed kinematic chains are summarized. Various efforts made to date for the control of coordinated multiple manipulators is summarized.

Hayati, Samad

1987-01-01

371

Phenylketonuria - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Phenylketonuria - Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Phenylketonuria or PKU English (Arabic) ???? ????? ??????? -- ??? ...

372

Ovarian Cysts - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Ovarian Cysts - Multiple Languages Arabic (???????) Spanish (español) Arabic (???????) Ovarian Cysts English (Arabic) ??????? ???????? - ??????? Multimedia Patient Education ...

373

Evolution of multiple supernova remnants  

NASA Astrophysics Data System (ADS)

Heating of the interstellar medium (ISM) by multiple supernova (SN) explosions is at the heart of producing galaxy-scale outflows in starburst galaxies. Standard models of outflows assume a high efficiency of SNe in heating the gas to X-ray emitting temperatures and filling the central region of starburst with hot gas, in order to launch vigorous outflows. We use hydrodynamical simulations to study the efficiency of multiple SNe in heating the ISM and filling the volume with gas of high temperatures. We argue that it is important for SN remnants to have a large filling factor and a large heating efficiency. For this, they have to be clustered in space and time, and keep exploding until the hot gas percolates through the whole region, in order to compensate for the radiative loss. In the case of a limited number of SNe, we find that although the filling factor can be large, the heating efficiency declines after reaching a large value. In the case of a continuous series of SNe, the hot gas (T ? 3 × 106 K) can percolate through the whole region after the total volume filling factor reaches a threshold of ˜0.3. The efficiency of heating the gas to X-ray temperatures can be ?0.1 after this percolation epoch, which occurs after a period of ?10 Myr for a typical starburst SN rate density of ?SN ? 10-9 pc-3 yr-1 and gas density of n ? 10 cm-3 in starburst nuclei regions. This matches the recent observations of a time delay of similar order between the onset of star formation and galactic outflows. The efficiency to heat gas up to X-ray temperatures (?106.5 K) roughly scales as ? _SN^{0.2} n^{-0.6}. For a typical SN rate density and gas density in starburst nuclei, the heating efficiency is ˜0.15, also consistent with previous interpretations from X-ray observations. We discuss the implications of our results with regard to observational diagnostics of ionic ratios and emission measures in starburst nuclei regions.

Vasiliev, Evgenii O.; Nath, Biman B.; Shchekinov, Yuri

2015-01-01

374

Multiple representations of work-energy processes  

NSDL National Science Digital Library

An energy process can be represented by verbal, pictorial, bar chart, and mathematical representations. This multiple-representation method for work-energy processes has been introduced and used in the work-energy part of introductory college physics courses. Assessment indicates that the method, especially the qualitative work-energy bar charts, serves as a useful visual tool to help students understand work-energy concepts and to solve related problems. This paper reports how the method has been used to teach work-energy concepts, student attitudes toward this approach, and their performance on work-energy problems.

Van Heuvelen, Alan; Zou, Xueli

2005-10-17

375

Management and prognosis of multiple myeloma.  

PubMed

Patients with asymptomatic or smoldering multiple myeloma should not be treated but should be observed closely for progression. For symptomatic myeloma, chemotherapy is indicated. Melphalan, the agent of choice, should be given with prednisone for 1 week of every 6 weeks, If melphalan brings no response, or response and then relapse, cyclophosphamide (Cytoxan) should be give intravenously every 4 weeks or orally every day. BCNU, CCNU, and doxorubicin (Adriamycin) have also shown activity in myeloma. Hypercalcemia occurs in one-third of patients and should be countered with hydration, corticosteroids, Neutra-Phos, or mithramycin. Long-term hemodialysis has achieved some success. The combination of sodium flouride and calcium carbonate produces new bone formation; it seems a useful adjunct in treatment for myelomatous bone disease. Radiation should be utilized only for severe, localized pain or for solitary lesions. Survival with multiple myeloma varies, mean durations being 2 to 3 years. Multivariate analysis indicates that serum creatinine and calcium levels are the most significant indicators regarding 2-year survival. We have found monoclonal proteinuria not significantly more frequent with renal insufficiency than with normal renal function, renal insufficiency not significantly more frequent with lambda than with kappa chains, and survival not significantly greater with IgG myeloma than with IgA. PMID:792581

Kyle, R A; Elveback, L R

1976-12-01

376

Cannabinoids, multiple sclerosis and neuroprotection.  

PubMed

The cannabinoid signaling system participates in the control of cell homeostasis in the CNS, which explains why, in different neurodegenerative diseases including multiple sclerosis (MS), alterations in this system have been found to serve both as a pathogenic factor (malfunctioning of this system has been found at early phases of these diseases) and as a therapeutic target (the management of this system has beneficial effects). MS is an autoimmune disease that affects the CNS and it is characterized by inflammation, demyelination, remyelination, gliosis and axonal damage. Although it has been considered mainly as an inflammatory disorder, recent studies have recognized the importance of axonal loss both in the progression of the disorder and in the appearance of neurological disability, even in early stages of the disease. In recent years, several laboratories have addressed the therapeutic potential of cannabinoids in MS, given the experience reported by some MS patients who self-medicated with marijuana. Most of these studies focused on the alleviation of symptoms (spasticity, tremor, anxiety and pain) or on the inflammatory component of the disease. However, recent data also revealed the important neuroprotective action that could be exerted by cannabinoids in this disorder. The present review will be precisely centered on this neuroprotective potential, which is based mainly on antioxidant, anti-inflammatory and anti-excitotoxic properties, exerted through the activation of CB1 or CB2 receptors or other unknown mechanisms. PMID:22112258

de Lago, Eva; Gómez-Ruiz, María; Moreno-Martet, Miguel; Fernández-Ruiz, Javier

2009-11-01

377

Inherited predisposition to multiple myeloma  

PubMed Central

Multiple myeloma (MM) is the second most common hematologic malignancy in the United States, after non-Hodgkin lymphoma. Family pedigree analyses of high-risk families, case-control studies and racial disparities in disease incidence all point to a potential inherited predisposition to MM. Genome-wide association studies (GWASs) have identified susceptibility loci in a number of cancers and such studies are currently underway in MM. To date, GWASs in MM have identified several potential regions of interest for further study on chromosomes 3p22, 7p15.3, 8q24 and 2p23.3. In addition, several targets of paraproteins (so called ‘paratargs’) in MM have been identified. Hyperphosphorylation of the paratarg protein, which is inherited in an autosomal dominant manner, appears a common mechanism underlying the antigenicity of these proteins. One particular protein, hyperphosphorylated paratarg-7 (pP-7) is a common target in persons with myeloma and has also been identified in affected members of several high-risk MM families. It appears that the frequency of pP-7 as an antigenic target may be particularly high in African American patients with MM, which could be part of the explanation for observed racial disparities in the incidence of MM. In this review we focus on available data in the area of inherited predisposition to MM, and highlight future research directions. PMID:23926460

Koura, Divya T.

2013-01-01

378

Islamic fasting and multiple sclerosis  

PubMed Central

Background Month-long daytime Ramadan fasting pose s major challenges to multiple sclerosis (MS) patients in Muslim countries. Physicians should have practical knowledge on the implications of fasting on MS. We present a summary of database searches (Cochrane Database of Systematic Reviews, PubMed) and a mini-symposium on Ramadan fasting and MS. In this symposium, we aimed to review the effect of fasting on MS and suggest practical guidelines on management. Discussion In general, fasting is possible for most stable patients. Appropriate amendment of drug regimens, careful monitoring of symptoms, as well as providing patients with available evidence on fasting and MS are important parts of management. Evidence from experimental studies suggests that calorie restriction before disease induction reduces inflammation and subsequent demyelination and attenuates disease severity. Fasting does not appear to have unfavorable effects on disease course in patients with mild disability (Expanded Disability Status Scale (EDSS) score ?3). Most experts believed that during fasting (especially in summer), some MS symptoms (fatigue, fatigue perception, dizziness, spasticity, cognitive problems, weakness, vision, balance, gait) might worsen but return to normal levels during feasting. There was a general consensus that fasting is not safe for patients: on high doses of anti-convulsants, anti-spastics, and corticosteroids; with coagulopathy or active disease; during attacks; with EDSS score ?7. Summary These data suggest that MS patients should have tailored care. Fasting in MS patients is a challenge that is directly associated with the spiritual belief of the patient. PMID:24655543

2014-01-01

379

Multiple pathways regulate shoot branching.  

PubMed

Shoot branching patterns result from the spatio-temporal regulation of axillary bud outgrowth. Numerous endogenous, developmental and environmental factors are integrated at the bud and plant levels to determine numbers of growing shoots. Multiple pathways that converge to common integrators are most probably involved. We propose several pathways involving not only the classical hormones auxin, cytokinins and strigolactones, but also other signals with a strong influence on shoot branching such as gibberellins, sugars or molecular actors of plant phase transition. We also deal with recent findings about the molecular mechanisms and the pathway involved in the response to shade as an example of an environmental signal controlling branching. We propose the TEOSINTE BRANCHED1, CYCLOIDEA, PCF transcription factor TB1/BRC1 and the polar auxin transport stream in the stem as possible integrators of these pathways. We finally discuss how modeling can help to represent this highly dynamic system by articulating knowledges and hypothesis and calculating the phenotype properties they imply. PMID:25628627

Rameau, Catherine; Bertheloot, Jessica; Leduc, Nathalie; Andrieu, Bruno; Foucher, Fabrice; Sakr, Soulaiman

2014-01-01

380

Escalating immunotherapy of multiple sclerosis.  

PubMed

Basic disease-modifying treatment for relapsing forms of active multiple sclerosis (MS) is now available in many countries with high prevalence rates, for this chronic inflammatory disease of the central nervous system. Several lines of evidence support early immunomodulatory treatment with either recombinant interferon-beta or glatiramer acetate, and positive results from phase III trials encourage start of treatment even in patients with clinically isolated syndromes (CIS). However, currently available drugs for basic therapy are only partially effective and patients may still encounter relapses or disease progression. As treatment-refractory, clinically active MS can quickly lead to irreversible neurological disability there is an urgent need for effective escalating strategies. Patients with suboptimal treatment response to basic therapy have been treated with combination therapies, cytotoxic drugs (such as mitoxantrone and cyclophosphamide) or autologous hematopoietic stem cell transplantation. Recently, the monoclonal antibody, natalizumab, was added to this armamentarium. None of these strategies have been vigorously evaluated in large randomized, controlled phase III trials with patients who failed basic therapy. Therefore, the decision to escalate immunotherapy is still based on limited evidence. This article will review potential candidates for intensified immunosuppression and call for innovative study designs to better evaluate escalating immunotherapy in MS. PMID:21180576

Rieckmann, Peter; Traboulsee, Anthony; Devonshire, Virginia; Oger, Joel

2008-11-01

381

Multiple zone multifocal phase designs.  

PubMed

New multifocal phase designs aiming at expanding depth of focus in the presbyopic eye are presented. The designs consist of multiple radial or angular zones of different powers or of combined low- and high-order aberrations. Multifocal performance was evaluated in terms of the dioptric range for which the optical quality is above an appropriate threshold, as well as in terms of the area under the through-focus optical quality curves. For varying optical power designs optimal through-focus performance was found for a maximum of three to four zones. Furthermore adding more zones decreased the optical performance of the solution. Angular zone designs provided better multifocal performance (1.95 times on average) than radial zone designs with identical number of zones and the same power range. The optimal design (angular design with three zones) surpassed by 33% the multifocal performance of a bifocal angular zone design and by 32% a standard multifocal phase plate with induced spherical aberration only. By using combinations of low- and high-order aberrations the through-focus range can be extended further by another 0.5 D beyond that of the best design of varying optical power. These designs can be implemented in adaptive optics systems for testing their visual performance in subjects and converted into multifocal contact lenses, intraocular lenses, or presbyopic corneal laser ablation profiles. PMID:24104805

de Gracia, Pablo; Dorronsoro, Carlos; Marcos, Susana

2013-09-15

382

Multiple access mass storage network  

SciTech Connect

The Multi-Access Storage Subnetwork (MASS) is the latest addition to the Octopus computer network at Lawrence Livermore Laboratory. The subnetwork provides shared mass storage for the Laboratory's multiple-host computer configuration. A Control Data Corp. 38500 Mass Storage facility is interfaces by MASS to the large, scientific worker computers to provide an on-line capacity of 1 trillion bits of user-accessible data. The MASS architecture offers a very high performance approach to the management of large data storage, as well as a high degree of reliability needed for operation in the Laboratory's timesharing environment. MASS combines state-of-the-art digital hardware with an innovative system philosophy. The key LLL design features of the subnetwork that contribute to the high performance include the following: a data transmission scheme that provides a 40-Mbit/s channel over distances of up to 1000 ft, a large metal-oxide-semiconductor (MOS) memory buffer controlled by a 24-port memory multiplexer with an aggregate data rate of 280 Mbit/s, and a set of high-speed microprocessor-based controllers driving the commercial mass storage units. Reliability of the system is provided by a completely redundant network, including two control minicomputer systems. Also enhancing reliability is error detection and correction in the MOS memory. A hardware-generated checksum is carried with each file throughout the entire network to ensure integrity of user files. 6 figures, 1 table.

Wentz, D.L. Jr.

1980-01-01

383

Urinary dysfunction in multiple sclerosis.  

PubMed

We aimed to determine the prevalence of urinary symptoms and complications in multiple sclerosis (MS) and to investigate the correlation of these symptoms and complications with urodynamic findings and disease characteristics (primary progressive, relapsing-remitting and secondary progressive). Fifty-two patients with MS were enrolled in the study. Patients were divided into three clinical types: primary progressive, relapsing-remitting and secondary progressive. Urological symptoms and complications were recorded. Each patient underwent a urodynamic investigation. Patients were evaluated for overall disability using the Expanded Disability Status Scale (EDSS). We found that 22 patients had primary progressive, 18 patients had relapsing-remitting and 12 patients had secondary progressive MS. Urgency was the most frequent urinary symptom (65%). Urinary infection was the most frequent urinary complication (15%). Detrusor hyperreflexia was found to be the main bladder dysfunction (27%). Detrusor sphincter dyssynergia was found in 25% of patients, and detrusor hyporeflexia was detected in 6%. No relationship was found between urinary symptoms and urodynamic abnormalities (p>0.05) and between urinary complications and urodynamic findings (p>0.05). No significant correlation was found between disease characteristics and urinary symptoms, urinary complications or urodynamic findings (p>0.05). We suggest that the assessment of urological symptoms and urodynamic evaluation is critical for evaluating quality of life in MS. PMID:19560927

Nakipoglu, G F; Kaya, A Z; Orhan, G; Tezen, O; Tunc, H; Ozgirgin, N; Ak, F

2009-10-01

384

Electrically actuated multiple store launcher  

NASA Astrophysics Data System (ADS)

This invention comprises a multi-store, electrical pulse initiated launcher that fits into, and is electrically connected with a transporting vehicle and that contains sequentially stacked assemblies. An electrical pulse from the transporting vehicle causes a resistor with the least value to transfer the electric sufficient gas pressure to force the store out of the launcher. The present invention discloses an electrically-actuated, multi-store dispenser wherein an initial electrical charge ignites gas cartridges causing sequential launching of stores from their tandem position inside a launch container. In some environments, it is desirable to dispense multiple stores from a launch vehicle, for instance sonobuoys, in dense patterns. Due to physical limitations of space in the dispensing vehicle, an effort was made to miniaturize the active components inside the store and therefore reduce the overall outer dimensions thereof. Once the size of the store was reduced, in order to meet the demands of the denser patterns, the inside of the individual launch containers were modified to allow each to hold and dispense more than one store. This new type of launch container, in addition to maintaining the size requirement dictated by the transporting vehicle, is operated by the vehicle's electrical system.

Marshall, Frank P.; Travor, Bruce W.

1991-12-01

385

Optical multiple access intersatellite links  

NASA Astrophysics Data System (ADS)

The feasibility of an optical implementation of a multiple access medium data rate data relay service on the timescale of Euro-DRS was assessed. The service requirements for the feasibility study are based on the service which, in existing or planned systems, is implemented at S band. The system should communicate simultaneously with up to 8 LEO users in orbits of radii up to 7400 km providing 8 independently agile links. On each link, it should communicate at up to 2Mb/sec, at bit error rates of 10 to the minus 6th power in the return direction (LEO to GEO). A design concept for the GEO central node was produced. Mass and power estimates were evaluated and a preliminary spacecraft accommodation study performed. The system weighs 130 kg and has a power consumption of 300 W. The optical subsystem occupies a 75 x 75 x 30 cm volume on the top floor of the spacecraft. A number of trade-offs were identified and performed in reaching the final system configuration. The system should have 1 telescope system per user, a periscope mirror configuration for coarse pointing, a single telescope for both transmit and receive, and the use of both 0.8 micron for the LEO-GEO link and 1.3 micron for GEO-LEO.

Grant, M. A.; Matthews, N. F.; Robson, D.

1988-03-01

386

Natalizumab therapy of multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is the commonest disabling neurological disease of young and middle-aged adults affecting 1 million persons world wide. The illness begins with a relapsing-remitting MS course in 85%–90% of patients; the other 10%–15% have a primary progressive onset MS. Our current understanding is that MS is an autoimmune disorder with an inflammatory T-cell attack on myelin or some component of the oligodendrocyte--myelin structure. Relapses of disease activity result in plaques of demyelination with destruction of myelin and, to a lesser, extent axons. Lymphocytes within the central nervous system tissue recruit more cells leading to an inflammatory cascade that causes myelin damage, axonal disruption, and neuronal death. If the plaque occurs in a vocal area of the central nervous system then symptoms relating to that area result. However, magnetic resonance imaging shows that approximately 10 times more lesions occur in asymptomatic areas of the brain. Recovery from an initial relapse may appear relatively complete but persistent inflammation results in axonal injury and residual disability results. With time and accumulated lesion load, secondary degeneration of denuded axons results in the phase of secondary progressive MS usually 15-20 years after onset. PMID:20874255

Hutchinson, Michael

2010-10-01

387

Neuroendocrine Immunoregulation in Multiple Sclerosis  

PubMed Central

Currently, it is generally accepted that multiple sclerosis (MS) is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin. In this respect, intrinsic or extrinsic factors such as emotional, psychological, traumatic, or inflammatory stress as well as a variety of other lifestyle interventions can influence the neuroendocrine system. On its turn, it has been demonstrated that the neuroendocrine system has immunomodulatory potential. Moreover, the neuroendocrine and immune systems communicate bidirectionally via shared receptors and shared messenger molecules, variously called hormones, neurotransmitters, or cytokines. Discrepancies at any level can therefore lead to changes in susceptibility and to severity of several autoimmune and inflammatory diseases. Here we provide an overview of the complex system of crosstalk between the neuroendocrine and immune system as well as reported dysfunctions involved in the pathogenesis of autoimmunity, including MS. Finally, possible strategies to intervene with the neuroendocrine-immune system for MS patient management will be discussed. Ultimately, a better understanding of the interactions between the neuroendocrine system and the immune system can open up new therapeutic approaches for the treatment of MS as well as other autoimmune diseases. PMID:24382974

Lee, Wai-Ping; Berneman, Zwi N.

2013-01-01

388

Potassium channels – multiplicity and challenges  

PubMed Central

The development of our knowledge of the function, structure and pharmacology of K+ channels is briefly outlined. This is the most diverse of all the ion channel families with at least 75 coding genes in mammals. Alternative splicing as well as variations in the channel subunits and accessory proteins that co-assemble to form the functional channel add to the multiplicity. Whereas diversity of this order suggests that it may be possible to develop new classes of drug, for example, for immunomodulation and some diseases of the central nervous system, the ubiquity of K+ channels imposes stringent requirements for selectivity. Animal toxins from the snake, bee and scorpion provide useful leads, though only in a few instances (e.g. with apamin) it has been possible to produce non-peptidic analogues of high potency. The scale of the resources needed to identify, and characterize fully, specific K+ channel as targets and then develop modulators with the required selectivity presents a challenge to both academic and applied pharmacologists. PMID:16402122

Jenkinson, Donald H

2006-01-01

389

Taking a "Simple View" of the Dynamic Indicators of Basic Early Literacy Skills as a Predictor of Multiple Measures of Third-Grade Reading Comprehension  

ERIC Educational Resources Information Center

The purpose of this study was to examine the validity evidence of first-grade Dynamic Indicators of Basic Early Literacy Skills (DIBELS) scores for predicting third-grade reading comprehension scores. We used the "simple view" of reading as the theoretical foundation for examining the extent to which DIBELS subtest scores predict…

Munger, Kristen A.; Blachman, Benita A.

2013-01-01

390

Insights into the evolution of freshwater sponges (Porifera: Demospongiae: Spongillina): Barcoding and phylogenetic data from Lake Tanganyika endemics indicate multiple invasions and unsettle existing taxonomy.  

PubMed

Sponges are a conspicuous element in many benthic habitats including in Africa's oldest, deepest lake, Lake Tanganyika. Despite their prevalence and pivotal ecological role as filter feeders, knowledge of the evolutionary history of sponges is in its infancy. Here, we provide the first molecular analysis targeting the evolution of sponges from Lake Tanganyika. Independent markers indicate the occurrence of several colonisation events which have shaped the current Tanganyikan lacustrine sponge biodiversity. This is in contrast to a range of previously studied organisms that have diversified within the lake from single lineages. Our tree reconstructions indicate the presence of two genera, Oncosclera and Eunapius, which are globally distributed. Therefore, we reject the hypothesis of monophyly for the sponges from Lake Tanganyika and challenge existing higher taxonomic structure for freshwater sponges. PMID:21669294

Erpenbeck, Dirk; Weier, Tina; de Voogd, Nicole J; Wörheide, Gert; Sutcliffe, Patricia; Todd, Jonathan A; Michel, Ellinor

2011-10-01

391

Objectively-assessed and self-reported sedentary time in relation to multiple socioeconomic status indicators among adults in England: a cross-sectional study  

PubMed Central

Objectives To examine the associations between socioeconomic position (SEP) and multidomain self-reported and objectively-assessed sedentary time (ST). Design Cross-sectional. Setting General population households in England. Participants 2289 adults aged 16–96?years who participated in the 2008 Health Survey for England. Outcomes Accelerometer-measured ST, and self-reported television time, non-television leisure-time sitting and occupational sitting/standing. We examined multivariable associations between household income, social class, education, area deprivation for each SEP indicator (including a 5-point composite SEP score computed by aggregating individual SEP indicators) and each ST indicator using generalised linear models. Results Accelerometry-measured total ST and occupational sitting/standing were positively associated with SEP score and most of its constituent SEP indicators, while television time was negatively associated with SEP score and education level. Area-level deprivation was largely unrelated to ST. Those in the lowest composite SEP group spent 64 (95% CIs 52 to 76) and 72 (48 to 98), fewer minutes/day in total ST and occupational sitting/standing compared to those in the top SEP group, and an additional 48 (35–60) min/day watching television (p<0.001 for linear trend). Stratified analyses showed that these associations between composite SEP score and total ST were evident only among participants who were in employment. Conclusions Occupational sitting seems to drive the positive association between SEP and total ST. Lower SEP is linked to higher TV viewing times. PMID:25377012

Stamatakis, Emmanuel; Coombs, Ngaire; Rowlands, Alex; Shelton, Nicola; Hillsdon, Melvyn

2014-01-01

392

Exploring Two Phases of Design-by-Analogy "Multiple Solutions" and "Multiple Analogies"  

E-print Network

from a single source analog when instructed to do so. 2. The mapping of high level principles increases with the increase in the number of example analogs and decreases with the amount of noise. Two experiments, "Multiple Solutions" and "Multiple...

Gadwal, Apeksha

2010-10-12

393

Effects of Creatine and Sodium Bicarbonate Co-Ingestion on Multiple Indices of Mechanical Power Output During Repeated Wingate Tests in Trained Men.  

PubMed

This study investigated the effects of creatine and sodium bicarbonate co-ingestion on mechanical power during repeated sprints. Nine well-trained men (age = 21.6 ± 0.9 yr, stature = 1.82 ± 0.05 m, body mass = 80.1 ± 12.8 kg) participated in a double-blind, placebo-controlled, counterbalanced, crossover study using six 10-s repeated Wingate tests. Participants ingested either a placebo (0.5 g·kg-1 of maltodextrin), 20 g·d-1 of creatine monohydrate + placebo, 0.3 g·kg-1 of sodium bicarbonate + placebo, or co-ingestion + placebo for 7 d, with a 7 d washout between conditions. Participants were randomised into two groups with a differential counterbalanced order. Creatine conditions were ordered first and last. Indices of mechanical power output (W), total work (J) and fatigue index (W·s-1) were measured during each test and analysed using the magnitude of differences between groups in relation to the smallest worthwhile change in performance. Compared to placebo, both creatine (effect size (ES) = 0.37-0.83) and sodium bicarbonate (ES = 0.22-0.46) reported meaningful improvements on indices of mechanical power output. Co-ingestion provided small meaningful improvements on indices of mechanical power output (W) compared to sodium bicarbonate (ES = 0.28-0.41), but not when compared to creatine (ES = -0.21-0.14). Co-ingestion provided a small meaningful improvement in total work (J) (ES = 0.24) compared to creatine. Fatigue index (W·s-1) was impaired in all conditions compared to placebo. In conclusion, there was no meaningful additive effect of creatine and sodium bicarbonate co-ingestion on mechanical power during repeated sprints. PMID:25203421

Griffen, Corbin; Rogerson, David; Ranchordas, Mayur; Ruddock, Alan

2014-09-01

394

A method for extracting burned areas from Landsat TM/ETM+ images by soft aggregation of multiple Spectral Indices and a region growing algorithm  

NASA Astrophysics Data System (ADS)

Since fire is a major threat to forests and wooded areas in the Mediterranean environment of Southern Europe, systematic regional fire monitoring is a necessity. Satellite data constitute a unique cost-effective source of information on the occurrence of fire events and on the extent of the area burned. Our objective is to develop a (semi-)automated algorithm for mapping burned areas from medium spatial resolution (30 m) satellite data. In this article we present a multi-criteria approach based on Spectral Indices, soft computing techniques and a region growing algorithm; theoretically this approach relies on the convergence of partial evidence of burning provided by the indices. Our proposal features several innovative aspects: it is flexible in adapting to a variable number of indices and to missing data; it exploits positive and negative evidence (bipolar information) and it offers different criteria for aggregating partial evidence in order to derive the layers of candidate seeds and candidate region growing boundaries. The study was conducted on a set of Landsat TM images, acquired for the year 2003 over Southern Europe and pre-processed with the LEDAPS (Landsat Ecosystem Disturbance Adaptive Processing System) processing chain for deriving surface spectral reflectance ?i in the TM bands. The proposed method was applied to show its flexibility and the sensitivity of the accuracy of the resulting burned area maps to different aggregation criteria and thresholds for seed selection. Validation performed over an entire independent Landsat TM image shows the commission and omission errors to be below 21% and 3%, respectively.

Stroppiana, D.; Bordogna, G.; Carrara, P.; Boschetti, M.; Boschetti, L.; Brivio, P. A.

2012-04-01

395

Multiple description quantizer design for multiple-antenna systems with MAP detection  

Microsoft Academic Search

We study the design of index assignment based multiple description quantizers for multiple-antenna systems with slow Rayleigh fading. A time-interleaver is employed at the transmitter to provide independent channel instances for the multiple descriptions, and a maximum a posteriori (MAP) detector is employed at the receiver to jointly decode the multiple descriptions. The concatenation of index assignment, binary phase-shift keying

Yugang Zhou; Wai-Yip Chan

2010-01-01

396

Concatenated codes for the multiple-input multiple-output quasi-static fading channel  

E-print Network

CONCATENATED CODES FOR THE MULTIPLE-INPUT MULTIPLE-OUTPUT QUASI-STATIC FADING CHANNEL A Dissertation by VIVEK GULATI Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree... of DOCTOR OF PHILOSOPHY December 2004 Major Subject: Electrical Engineering CONCATENATED CODES FOR THE MULTIPLE-INPUT MULTIPLE-OUTPUT QUASI-STATIC FADING CHANNEL A Dissertation by VIVEK GULATI Submitted to Texas A&M University in partial fulfillment...

Gulati, Vivek

2005-02-17

397

SEMIPARAMETRIC ESTIMATION OF MULTIPLE EQUATION MODELS  

Microsoft Academic Search

This paper proposes a semiparametric estimator for multiple equations multiple index (MEMI) models. Examples of MEMI models include several sample selection models and the multinomial choice model. The proposed estimator minimizes the average distance between the dependent variable unconditional and conditional on an index. The estimator is N-consistent and asymptotically normally distributed. The paper also provides a Monte Carlo experiment

Gabriel A. Picone; J. S. Butler

2000-01-01

398

Personal identity, multiple personality, and hypnosis  

Microsoft Academic Search

The concept of multiple personality ia critically examined in the light of its historical development. Various conceptions of multiple personality are considered: aa a diagnostic fashion; aa a product of shaping in therapy; as a product of hypnotic suggestion; as simulation; and aa an extension of characteristica found in “normal” personslitiea. These considerations lead to the conclusion that the significant

J. P. Sutcliffe; Jean Jones

1962-01-01

399

Multiple access studies of multibeam communication satellites  

Microsoft Academic Search

The next generations of communications satellites are expected to employ satellite switched multiple spot beams to increase the system. The use of multiple spot beam systems in a packet switched environment with a large number of small bursty users is studied. A system is considered which achieves frequency reuse by using sub 2 nonoverlapping spot beams with sub T frequency

J. G. Garde

1981-01-01

400

Psychophysiologic Phenomena in Multiple Personality and Hypnosis  

Microsoft Academic Search

This article demonstrates similarities in psychophysiologic phenomena found in Multiple Personality Disorder (MPD), individuals using hypnosis, and others who did not use hypnosis. The areas discussed are: allergic responses, dermatologic reactions, effects on the autonomic nervous system, seizure disorders, pain control, and healing. Examples from multiple personality cases are paralleled by citations of related phenomena from the hypnosis literature. Some

Bennett G. Braun

1983-01-01

401

Extracting Coactivated Features from Multiple Data Sets  

E-print Network

Extracting Coactivated Features from Multiple Data Sets Michael U. Gutmann and Aapo Hyv¨arinen Dept generalization of Canonical Corre- lation Analysis (CCA) to find related structure in multiple data sets. The new method allows to analyze an arbitrary number of data sets, and the extracted features capture higher

Gutmann, Michael

402

Extracting Coactivated Features from Multiple Data Sets  

E-print Network

Extracting Coactivated Features from Multiple Data Sets Michael U. Gutmann and Aapo Hyv¨arinen Dept of Canonical Corre- lation Analysis (CCA) to find related structure in multiple data sets. The new method allows to analyze an arbitrary number of data sets, and the extracted features capture higher

Hyvärinen, Aapo

403

Designed multiple ligands for cancer therapy.  

PubMed

The concept of a single chemical entity with desirable activity at more than one biological target is an attractive one. Increasingly, multiple complex biochemical pathways are implicated in a variety of diseases including cancer. Successful treatment of these conditions often depends on pharmaceutical intervention at multiple pathways, with a combination of different drugs. Designed multiple ligands (DMLs) are drugs which act at multiple biomolecular targets. Numerous terms have been used to describe such ligands, including multiple-target directed ligands, heterodimers, promiscuous drugs and pan-agonists. However, although there are many reported examples of multiple-targeting anti-cancer agents, no review of these has been presented to date. A huge variety of biological signalling-pathways, proteins and enzymes are currently targeted and implicated in the pathogenesis of cancer. This review will provide an overview of reported designed multiple ligands for cancer and an exploration of the advantages and drawbacks of such compounds. The review also provides brief commentaries on the biological processes and proteins that are currently targeted in cancer therapy and the potential for dual or triple targeting of these with designed multiple ligands. PMID:21919848

O'Boyle, N M; Meegan, M J

2011-01-01

404

Multiple Memory Systems: What and Why  

Microsoft Academic Search

Evidence from a variety of domains converges on the view that there are multiple learning\\/memory systems, but there is no clear understanding of what these systems are, and why they should exist. I review an hypothesis about multiple memory systems postulated by O'Keefe and Nadel (The hippocampus ac a Cognitive map, Oxford: Clarendon Press, 1978), in particular our assertions about

Lynn Nadel

1992-01-01

405

Multiple Intelligences: A Wealth of Human Potential.  

ERIC Educational Resources Information Center

This issue focuses on the multiple types of intelligences that students and teachers possess, and provides tips for using this information in the business education classroom. The following articles are included: "How Do Students Learn Best and How Can Teachers Best Help Them?"; "Multiple Intelligences in Action in the Business Classroom";…

Keying In, 1997

1997-01-01

406

Multiple language supports in search engines  

Microsoft Academic Search

Purpose – This paper aims to investigate the multiple language support features in internet search engines. The diversity of the internet is reflected not only in its users, information formats and information content, but also in the languages used. As more and more information becomes available in different languages, multiple language support in a search engine becomes more important. Design\\/methodology\\/approach

Jin Zhang; Suyu Lin

2007-01-01

407

A framework to support multiple reconfiguration strategies  

Microsoft Academic Search

Self-management is a key feature of autonomic systems. This often demands the dynamic reconguration of a distributed application. An important issue in the reconguration pro- cess is the strategy that is used to coordinate the multiple participants involved in the reconguration. This paper ad- dresses the problem of providing support for multiple recon- guration strategies in autonomic systems that are

Liliana Rosa; Luís Rodrigues; Antónia Lopes

2007-01-01

408

Multiple Antenna Broadcast Channels With Limited Feedback  

Microsoft Academic Search

In this paper, we study the limited feedback model for partial CSI at the basestation (BS) for multiple antenna broadcast channels: the BS has the knowledge of quantized CSI of each user. We first give a practical limited feedback scheme designed for multiple antenna broadcast channels. Then, we study the sum rate performance of zero-forcing dirty paper coding under the

Peilu Ding; D. J. Love; M. D. Zoltowski

2006-01-01

409

Paradoxical effects of temperature in multiple sclerosis  

Microsoft Academic Search

Six cases of multiple sclerosis are reported in which cold produced a temporary exacerbation of symptoms and signs of the disease. Also, in one case investigated in detail by psychophysical methods, heating produced a paradoxical deterioration in vision and simultaneous improvement in sensory and motor function. The effect of temperature in multiple sclerosis is discussed and a physiological explanation for

W. P. Honan; J. R. Heron; D. H. Foster; R. S. Snelgar

1987-01-01

410

Multiple Uses of a Word Study Technique  

ERIC Educational Resources Information Center

This paper presents two case studies that illustrate the multiple uses of word sorts, a word study phonics technique. Case study children were Sara, a second grader, who had difficulty with reading basic words and John, a third grader, who had difficulty with spelling basic words. Multiple baseline designs were employed to study the effects of…

Joseph, Laurice M.; Orlins, Andrew

2005-01-01

411

Multiple-Access Quantum-Classical Networks  

NASA Astrophysics Data System (ADS)

A multi-user network that supports both classical and quantum communication is proposed. By relying on optical code-division multiple access techniques, this system offers simultaneous key exchange between multiple pairs of network users. A lower bound on the secure key generation rate will be derived for decoy-state quantum key distribution protocols.

Razavi, Mohsen

2011-10-01

412

Multiple-Inlet/Single-Outlet Orifice Plate  

NASA Technical Reports Server (NTRS)

Orifice plate for control of flow has multiple slanted inlets leading to single outlet. Multiple-inlet/single-outlet orifice less susceptible to blockage than single hole drilled through plate perpendicular to its surface. Easily calibrated for various flow rates and fits in place of simple orifice plate with no other modifications.

Godown, Robert L.

1990-01-01

413

Multiple sclerosis: a complicated picture of autoimmunity  

Microsoft Academic Search

Understanding of autoimmune diseases, including multiple sclerosis, has expanded considerably in recent years. New insights have been provided by not only animal models but also studies of patients, often in conjunction with experimental therapies. It is accepted that autoimmune T cells mediate the early steps of new multiple sclerosis lesions, and although uncertainties remain about the specific targets of autoreactive

Roland Martin; Henry F McFarland

2007-01-01

414

A Multiple Criteria Energy Decision Support System  

Microsoft Academic Search

Multiple Criteria Decision Analysis (MCDA) techniques are particularly suitable for Energy and Environment (E&E) decisions due to multiple criteria nature of these types of problems and they have been widely applied in this area. Main points that can be taken into consideration when examining the MCDA literature related to E&E are the selection of appropriate method, selection of criteria to

Kazim Baris Atici; Aydin Ulucan

2011-01-01

415

Multiple medical problems following agent orange exposure.  

PubMed

A patient exposed to agent orange and a gunshot wound during the Vietnam War has developed multiple medical problems including nocardiosis, onychomycosis (Trichophyton rubrum), multiple thromboembolic episodes, hemochromatosis, diabetes mellitus type 2, diabetic neuropathy, activated protein C resistance (without Leyden V 1st mutation), degree A-V block, lung cancer (metastatic adenocarcinoma), carpal tunnel syndrome and arthritis. PMID:18084883

Ambrus, J L; Islam, A; Akhter, S; Dembinski, W; Kulaylat, M; Ambrus, C M

2004-01-01

416

Multiple use of dialyzers: Safety and efficacy  

Microsoft Academic Search

Multiple use of dialyzers: Safety and efficacy. The practice of multiple use of dialyzers was examined over a 15-month period on all 104 patients in a chronic maintenance hemodialysis facility. A computerized medical information system permitted analysis of the incidence of events in over 10,000 successive hemodialyses. It also allowed analysis of the events in 27 patients dialyzed for a

Kotagal S Kant; Victor E Pollak; Margaret Cathey; Dan Goetz; Rebecca Berlin; David F Eydel; Judy Tessel; Roberta Hall

1981-01-01

417

Multiple hemorrhoidal bandings in a single session  

Microsoft Academic Search

PURPOSE: The aim of our study was to evaluate the risks of multiple hemorrhoidal bandings in a single session. METHODS: We retrospectively examined all of the patients who had hemorrhoidal bandings from July 1989 to August 1992. RESULTS: Patients with multiple hemorrhoidal banding in a single session when compared with patients with single banding had greater discomfort and pain (29

Henry H. Lee; Robert J. Spencer; Robert W. Beart

1994-01-01

418

Charged-track multiplicity of B  

Microsoft Academic Search

There are only ten stable charged particles (e, mu, pi, K and p and their antimatter partners) that can leave tracks in our detector. Due to detector inefficiency, the charged particles sometimes get lost and undetected. Therefore, the original parent charged track multiplicity is different from what we observe. We are interested in finding the original parent charged track multiplicity

Tong-Uk Lee

1999-01-01

419

Multiple Intelligences: A Collection. K-12.  

ERIC Educational Resources Information Center

Divided into five concise sections, this book introduces and examines the personage of Howard Gardner and his theory of multiple intelligences. The articles explore practical applications and implications of the theory and provide supporting evidence applicable to all children. Special applications of the multiple intelligences theory, including…

Fogarty, Robin, Ed.; Bellanca, James, Ed.

420

Hierarchical Depth Mapping from Multiple Cameras  

Microsoft Academic Search

. We present a method to estimate a dense and sharp depthmap using multiple cameras. A key issue in obtaining sharp depth map ishow to overcome the harmful influence of occlusion. Thus, we first proposean occlusion-overcoming strategy which selectively use the depthinformation from multiple cameras. With a simple sort and discard technique,we resolve the occlusion problem considerably at a slight

Jong-il Park; Seiki Inoue

1997-01-01

421

Enhancing Vocabulary Development in Multiple Classroom Contexts.  

ERIC Educational Resources Information Center

Describes ways teachers can enhance students' vocabulary development through multiple contexts available in typical middle school classroom settings. Addresses questions about vocabulary learning and offers suggestions for enhancing vocabulary with narrative and expository texts that involve multiple classroom contexts. Considers the Vocab-o-gram…

Harmon, Janis M.; Staton, Denise G.

1999-01-01

422

On multiple access communications using spatial diversity  

Microsoft Academic Search

Information-theoretic results have shown significant gains in transmission rate over fading channels using multiple transmitter and receiver antenna (spatial) diversity. We review some of these results and show that these gains could also be achieved using simpler receiver structures. We then examine the rates achievable in a multiuser environment, i.e. a multiple access fading channel. The symmetric rate per user

S. N. Diggavi

1999-01-01

423

40 CFR 791.52 - Multiple tests.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 true Multiple tests. 791.52 Section 791...Order § 791.52 Multiple tests. When more than one of a particular kind of test required by the test rule is performed, the additional costs will be shared among...

2010-07-01

424

An unusual presentation of multiple hidrocystomas.  

PubMed

An 85-year-old man sought treatment of multiple nontender bluish papules of 3 years' duration on the forearms, forehead, and temples. On physical examination, blue-tinged, semitranslucent, dome-shaped papules were noted. Workup revealed multiple hidrocystomas. We discuss the findings in our patient and review the literature. PMID:22106725

Scribner, Jane; Regan, Thomas D; Steger, James W

2011-10-01

425

Multiple Voices in Young Adult Novels.  

ERIC Educational Resources Information Center

A stylistic device that has been used by many authors over the years is to alternate the point of view between two or more characters. Authors of young adult novels choose this technique of multiple narrative voices for a variety of reasons. Multiple voices offer a challenge to many young adult readers because the point of view is much more…

Capan, Mary Ann

426

Multiple View Consistency for Data Warehousing  

Microsoft Academic Search

A data warehouse stores integrated information from multiple distributed data sources. In effect, the warehouse stores materialized views over the source data. The prob- lem of ensuring data consistency at the warehouse can be divided into two components: ensuring that each view re- flects a consistent state of the base data, and ensuring that multiple views are mutually consistent. In

Yue Zhuge; Hector Garcia-molina; Janet L. Wiener

1997-01-01

427

Managing Multiple Goals in Real Learning Contexts  

ERIC Educational Resources Information Center

Understanding students' multiple goals in real learning contexts is an emerging area of importance for educators and researchers investigating student motivation in classrooms. This qualitative study conducted over an academic year investigates the multiple goals articulated by seven 11-year-old students and explores relationships between goals…

Mansfield, Caroline F.

2009-01-01

428

Multiple reservations and the Oklahoma update  

Microsoft Academic Search

A multiple reservation approach that allows atomic updates of multiple shared variables and simplifies concurrent and nonblocking codes for managing shared data structures such as queues and linked lists is presented. The method can be implemented as an extension to any cache protocol that grants write access to at most one processor at a time. Performance improvement, automatic restart, and

Janice M. Stone; H. S. Stone; P. Heidelberger; J. Turek

1993-01-01

429

Evidence of Multiple Intelligences in FLES Classrooms  

ERIC Educational Resources Information Center

According to the Theory of Multiple Intelligences of Howard Gardner, there are eight intelligences. In the present study with two FLES classes, 35 students were asked to present Spanish vocabulary to their class to link their preferences of techniques used to introduce the vocabulary to their classmates with a spectrum of their multiple

Glick, Beatriz Garcia; Armstrong, Joyce; Marchese, Marc

2010-01-01

430

Integrating multiple fish biomarkers and risk assessment as indicators of metal pollution along the Red Sea coast of Hodeida, Yemen Republic.  

PubMed

The marine environment of the Red Sea coast of Yemen Republic is subjected to increasing anthropogenic activities. The present field study assesses the impacts of metal pollutants on two common marine fish species; Pomadasys hasta and Lutjanus russellii collected from a reference site in comparison to two polluted sites along the Red Sea coast of Hodeida, Yemen Republic. Concentrations of heavy metals (Fe, Cu, Zn, Cd and Pb) in fish vital organs, metal pollution index (MPI), indicative biochemical parameters of liver functions (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) and kidney functions (urea and creatinine) as well as histopathological changes in gills, liver and kidney of both fish species are integrated as biomarkers of metal pollution. These biomarkers showed species-specific and/or site-specific response. The hazard index (HI) was used as an indicator of human health risks associated with fish consumption. The detected low HI values in most cases doesn't neglect the fact that the cumulative risk effects for metals together give an alarming sign and that the health of fish consumers is endangered around polluted sites. The levels of ALT, AST and urea in plasma of both fish species collected from the polluted sites showed significant increase in comparison to those of reference site. Histopathological alterations and evident damage were observed in tissues of fish collected from the polluted sites. The investigated set of biomarkers proved to be efficient and reliable in biomonitoring the pollution status along different pollution gradients. PMID:25261609

Omar, Wael A; Saleh, Yousef S; Marie, Mohamed-Assem S

2014-12-01

431

Multiple Fixed-Point Cell  

NASA Astrophysics Data System (ADS)

The paper describes the construction and investigation of multiple fixed-point cells usable for the calibration of thermocouples at temperatures above 1100 C. These fixed-point cells made of pure graphite are characterized by a simple construction as well as by a flexible application. The cylindrical basic mount is equipped with a central hole for the insertion of a thermocouple, and with eight drill holes containing exchangeable cartridges which surround the central bore axially symmetrically. The cartridges are filled with different metal-carbon (Me-C) eutectics: cobalt-carbon (Co-C), nickel-carbon (Ni-C), palladium-carbon (Pd-C), and rhodium-carbon (Rh-C). The melting temperatures of the different Me-C eutectics of the cartridges were compared to the melting temperatures of commonly used Me-C eutectic fixed-point cells of the Physikalisch-Technische Bundesanstalt by using a Pt/Pd thermocouple (Co-C, Ni-C) and Type B thermocouples (Pd-C, Rh-C). The uncertainties () of the emfs measured at the inflection points of the melting curves are in the order of a few V which correspond to temperature equivalents between 0.3 K and 0.6 K. Furthermore, the difference between the melting temperatures of the Co-C and Ni-C cartridges was found to be 4.2 K by using simultaneously two sets of four cartridges filled with the two materials and placed alternately in the eight outer holes of one basic mount.

Edler, F.; Ederer, P.

2014-07-01

432

The nature of multiple sclerosis.  

PubMed

Multiple sclerosis (MS) has recently been classified according to its clinical course. Despite relapses and remissions, its course is invariably progressive, and the observed progression from the remitting-relapsing to the secondary progressive form represents the accumulation of permanent damage to the nervous system. Discussions of the nomenclatural position of Schilder's, Marburg's, and Baló's diseases, ignore the fact that the unique, pathognomonic, sharp-edged plaque of MS, is also the pathologic end-result in the three variants. Devic's disease or neuromyelitis optica (NMO) is quite different and with some exceptions, is a particular form of disseminated encephalomyelitis (DEM). There is no evidence that the 'oriental form of MS' is anything but NMO. The suggestion that MS and DEM are variants of the same condition is contradicted by the fact that the pathological characteristics of the two are quite different. While it is probable that the two share aspects of pathogenesis, the patients differ because of their genetic endowment. This was dramatically demonstrated in a group of Japanese patients who died after anti-rabies vaccination and were found to have the typical sharp-edged lesions of MS. The genetic determinant was also crucial in the marmoset in which EAE uniquely resulted in a chronic relapsing-remitting (RR) disease characterized by the classic sharp-edged lesions of MS. The question 'ADEM: distinct disease or part of the MS spectrum?' can be answered with a resounding no. A new classification is proposed separating the different forms of MS from the various types of DEM. PMID:15177764

Poser, Charles M; Brinar, Vesna V

2004-06-01

433

Alemtuzumab therapy for multiple sclerosis.  

PubMed

Alemtuzumab is a humanized monoclonal antibody that is administered daily for 5 days, and then no further therapy is required for 12 months. It causes rapid and prolonged lymphocyte depletion; the consequent homeostatic reconstitution leads to a radically reformed lymphocyte pool with a relative increase in regulatory T cells and expansion of autoreactive T cells. Although previously licensed for the treatment of B-cell chronic lymphocytic leukemia, it is now been considered for licensing in the treatment of multiple sclerosis (MS). From a disappointing experience with alemtuzumab in progressive MS, Alastair Compston and I argued that immunotherapies should be given early in the course of the disease. In a unique program of drug development in MS, alemtuzumab has been compared in 1 phase 2 trial and 2 phase 3 trials with the active comparator interferon beta-1a. In all trials, alemtuzumab was more effective in suppressing relapses than interferon beta-1a. In one phase 2 and one phase 3 trial, alemtuzumab also reduced the risk of accumulating disability compared with interferon beta-1a. Indeed, alemtuzumab treatment led to an improvement in disability and a reduction in cerebral atrophy. The safety issues are infusion-associated reactions largely controlled by methylprednisolone, antihistamines, and antipyretics; mild-to-moderate infections (with 3 opportunistic infections from the open-label experience: 1 case each of spirochaetal gingivitis, pyogenic granuloma, and Listeria meningitis); and autoimmunity. Usually autoimmunity is directed against the thyroid gland, but causes (1 %) immune thrombocytopenia, and in a few cases antiglomerular basement membrane syndrome. Alemtuzumab is an effective therapy for early relapsing-remitting MS, offering disability improvement at least to 5 years after treatment. Its use requires careful monitoring so that potentially serious side effects can be treated early and effectively. PMID:23184314

Coles, Alasdair J

2013-01-01

434

Collaborative web browsing: multiple users, multiple pages, concurrent access, one display  

Microsoft Academic Search

Situations where users want to engage in collaborative web browsing are becoming increasingly common. However, current web technologies aren't designed to allow multiple users to browse the web simultaneously within a single common browser or application since they are unable to handle issues such as simultaneous access by multiple pointers, and multiple simultaneous points of focus within an application. The

Oliver Schmid; Agnes Lisowska Masson; Béat Hirsbrunner

2012-01-01

435

A generic input device for the multiple master multiple slave system  

Microsoft Academic Search

The growing demand for input devices designed for the severely handicapped led to development of modular features for the open architecture multiple master multiple slave (M3S) system. With its central safety monitor, M3S allows individuals suffering from cerebral palsy, paraplegia, or multiple sclerosis, and other physically debilitating illnesses greater autonomy by allowing them to access a wide range of input

Chiun-fan Chen; Yi-chu Chang; Heng-Yin Chen; Jin-shin Lai; Fok-ching Chong

2004-01-01

436

Multiple indices of soil nitrogen status and temperature regulate microbial C allocation to CO2, substrate choices, and contributions to SOM  

NASA Astrophysics Data System (ADS)

The response of microbial resource demand to many environmental variables, including temperature and natural organic and inorganic N variability, remains poorly understood. Furthermore, we do not understand how these variables can influence CO2 release vs. C retention in cell walls, which as microbial necromass can generate long-lived soil organic matter (SOM). We explore microbial resource demand and C retention vs. release in one temperate forest and two boreal forests along a climate gradient. We characterized SOM C:N and inorganic N, extracellular enzyme activity (E), and phospholipid fatty acid (PLFA) concentration and ?13C. Experimental warming permitted us to assess how interactions between soil N status and warming influence resource demand and C flows through microbes in the two boreal soils. For all soils, we used ?13C of respired CO2 and ?13CPLFA to generate indices of C allocation to biomass vs. to respiratory costs (?), useful for cross-site comparisons. Decreasing values of ? indicate a greater proportion of 13C-enriched C allocated to respiration relative to PLFA-C; changes in ? with warming or N status thus imply that these variables can influence the physiological mechanisms determining the fate of microbial C after it is imported into the cell. We thus were able to assess the influence of soil N status and warming on substrate decay via E, the fate of microbial C from diverse substrates via ?, and one index of microbial composition relevant to SOM formation [PLFA]. In all soils, E often varied with N status in ways predicted by stoichiometric theory. For example, the ratio of exo-enzymes associated with labile C decay to those linked to organic N decay (EC:N) increased with inorganic N, and EC:N declined as substrate C:N increased. In contrast to measures of decay, all soils exhibited distinct responses of microbial composition and C allocation to N status and warming. In the temperate forest soils, Gram+ bacteria responded positively to organic N availability and Gram- bacteria to inorganic N, while fungi responded positively to declines in both measures of soil N status. In the more northern boreal soils, actinomycete [PLFA] increased with inorganic N, while that of more southern boreal soils increased with substrate C:N; in both boreal soils, Gram+ bacteria increased with temperature. Given that cell walls of these microbes exhibit distinct propensities for forming long-lived SOM, our work illustrates how similar variation in N status and temperature can drive divergent patterns of biomass relevant to SOM formation. Sensitivity of patterns of C allocation to these variables also contrasted between these soils. In the temperate soils, ? did not vary with soil N status nor with E, implying that microbes' C allocation patterns were not driven N status or by the C's organic precursor. In both boreal soils, ? declined with warming, and as EC or EC:N increased. Though N status of the boreal soils drove resource demand similarly as in the temperate forest, the fate of boreal microbial C varied with N status and temperature. Because microbial C substrate use varied with warming in the boreal soils, ? highlights how the fate of microbial C may vary with the identity of its organic precursor, which in turn is influenced by environmental conditions like temperature and soil N status.

Billings, S. A.; Ziegler, S. E.

2012-12-01

437

Lipid D/H Ratios from Multiple Sources and Deposits Indicate Drier Little Ice Age at Washington Island (4°43`N, 160°25`W), Central Pacific  

NASA Astrophysics Data System (ADS)

To compare the sensitivity of biomarker D/H ratios from two distinct climate archives, a lake and a peat bog on the Tropical Pacific Island of Terrania, compound-specific hydrogen isotope ratios (expressed as ?D values) were determined on lipid biomarkers from various biological sources deposited in the two climate archives. At present, Terrania or Washington Island (4°43`N, 160°25`W) permanently lies in the intertropical convergence zone (ITCZ) and receives an annual precipitation of 2,903 mm. The interior of this lens shaped island contains a freshwater lake and peat bogs. Previous studies on the lake sediments found evidence for a substantially drier climate at times during the Little Ice Age (AD 1400-1850) based on the lithologic transition from modern freshwater sediments to a sequence of pure cyanobacterial mat in concert with ?D values from total lipid extracts (Sachs et al., 2009). Here we report on ?D values from lipids of various sources: dinoflagellate algae (dinosterol and a saturated C30 sterol (4? -methyl-24-ethyl-5? -cholestan-3?-ol), microbial sources (diploptene and nC21 alkane) and higher plants (fern-7-ene, ?-sitosterol and stigmastanol). Mean ?D values from all lipids, measured in both archives, are significantly enriched in deuterium by between 22 and 86‰ during previously inferred drier climate conditions and simultaneously record the transition towards a freshwater lake at around AD1550. Measured ?D values of all lipids cover a wide range from -281‰ to -105‰ during freshwater deposition and from -185‰ to -50‰ when climate was drier. In agreement with the observed isotopic difference between lipids produced via the acetogenic and the mevalonic acid biosynthetic pathway ?D values for algae and higher plant sterols are depleted in deuterium relative to the nC21 alkane by 150‰ on average. The consistent ?D values from dinosterol and 4? -methyl-24-ethyl-5? -cholestan-3?-ol from the lake and peat deposits signify the robustness of these lipid ?D values to indicate hydrologic changes in the sedimentary record. ?D values among lipids of similar and disparate sources and/or biosynthetic origin from Washington Island lake (AD ~ 800-1550) and peat bog (AD~1200-1660) sediments are significantly enriched in deuterium prior to AD 1560/1640 and thus both suggest drier climate conditions resembling today’s environmental and depositional setting at Christmas Island which is located 300km SSE of Washington Island beyond the influence of the ITCZ.

Muegler, I.; Sachse, D.; Sachs, J. P.

2010-12-01

438

Mapping freshwater deltaic wetlands and aquatic habitats at multiple scales with high-resolution multispectral WorldView-2 imagery and Indicator Species Analysis  

NASA Astrophysics Data System (ADS)

Remote sensing technology has long been used in wetland inventory and monitoring though derived wetland maps were limited in applicability and often unsatisfactory largely due to the relatively coarse spatial resolution of conventional satellite imagery. The advent of high-resolution multispectral satellite systems presents new and exciting capabilities in mapping wetland systems with unprecedented accuracy and spatial detail. This research explores and evaluates the use of high-resolution WorldView-2 (WV2) multispectral imagery in identifying and classifying freshwater deltaic wetland vegetation and aquatic habitats in the Selenga River Delta, a Ramsar Wetland of International Importance that drains into Lake Baikal, Russia - a United Nations World Heritage site. A hybrid approach was designed and applied for WV2 image classification consisting of initial unsupervised classification, training data acquisition and analysis, indicator species analysis, and final supervised classification. A hierarchical scheme was defined and adopted for classifying aquatic habitats and wetland vegetation at genus and community levels at a fine scale, while at a coarser scale representing wetland systems as broad substrate and vegetation classes for regional comparisons under various existing wetland classification systems. Rigorous radiometric correction of WV2 images and orthorectification based on GPS-derived ground control points and an ASTER global digital elevation model resulted in 2- to 3-m positional accuracy. We achieved overall classification accuracy of 86.5% for 22 classes of wetland and aquatic habitats at the finest scale and >91% accuracy for broad vegetation and aquatic classes at more generalized scales. At the finest scale, the addition of four new WV2 spectral bands contributed to a classification accuracy increase of 3.5%. The coastal band of WV2 was found to increase the separation between different open water and aquatic habitats, while yellow, red-edge, and near-infrared 2 bands were more useful for discriminating between different vegetated habitats. Analyses demonstrated that the Normalized Difference Vegetation Index was valuable for improving the classification accuracy and image texture was particularly useful for separating scrub/shrub wetland from various emergent herbaceous wetlands. Our analysis resulted in the first-ever detailed, quantitative wetland inventory map of the Selenga River Delta, and provides a benchmark for future wetland change detection studies and baseline information for wetland conservation and management efforts for this region.

Lane, C.; Liu, H.; Anenkhonov, O.; Autrey, B.; Chepinoga, V.

2012-12-01

439

Exhausting Multiple Hemodialysis Access Failures  

PubMed Central

ABSTRACT Introduction: Vascular access is often considered the Achilles heel the of hemodialysis because of its impact on morbidity, all cause mortality and finally costs of these patients. The most common complication of permanent hemodialysis (HD) vascular access is thrombosis, with some cases being related to hypercoagulability states. Antiphospholipid antibody syndrome (APAS) is a cause of increased thrombotic tendency, and this may complicate the management of such patients on HD. Case report: We describe a 41-year-old woman with end stage renal disease (ESRD) from Adult Polycystic Kidney Disease who was referred to our tertiary care center for treatment and selection of renal replacement therapy form. It was thought to initiate with peritoneal dialysis considering her actual conditions. She was putted on hemodialysis for several sessions, and a subclavian cathether was her first vascular access. The surgeon created an arterio-venous fistula which did not mature. After the implantation of the peritoneal cathether she started peritoneal dialysis and continued living with that for 2 years. She felt exhausted and because of a grave peritonitis episode accompanied with procedure failure and a long hospitalization she was transferred to hemodialysis. Renal transplantation was not possible because she didn’t have a kidney donation. She was maintained on regular HD, but her dialysis care was complicated by recurrent vascular access failures. She had multiple interventions for arterio-venous fistulas and grafts but almost all of them failed due to thrombosis to the extent that only one access site was available for her routine renal replacement treatment. A thorough thrombophilia screen confirmed the presence of antiphospholipid antibodies. A diagnosis of APAS was made and she was anticoagulated with warfarin. The AVG made in this last available site is still working from 18 months. If it fails we have no answers and solutions for her. Conclusion: The presence of APAS can complicate HD management by causing recurrent vascular access thrombosis and failure, and nephrologist must remain alert to this possibility. Checking and treating as soon as possible it's our future challenge. PMID:25568574

Bolleke, Erjola; Seferi, Saimir; Rroji, Merita; Idrizi, Alma; Barbullushi, Myftar; Thereska, Nestor

2014-01-01

440

Acute Infectious Morbidity in Multiple Gestation  

PubMed Central

Objectives. Physiologic and immunologic changes in pregnancy result in increased susceptibility to infection. These shifts are more pronounced in pregnancies complicated by multiple gestation. The objective of this study was to determine the association between multiple gestation and risk of infectious morbidity. Study Design. The Nationwide Inpatient Sample for the years 2008–2010 was used to identify pregnant women during admission for delivery with International Classification of Diseases codes. Logistic regression was used to compute odds ratios and 95% confidence intervals for demographic data, preexisting medical conditions, and acute medical and infectious complications for women with multiple versus singleton gestations. Results. Among women with multiple gestation, 38.4 per 1,000 women had an infectious complication compared to 12.8 per 1,000 women with singletons. The most significant infectious morbidity associated with multiple gestation was intestinal infections, pyelonephritis, influenza, and pneumonia. After controlling for confounding variables, infectious complications at delivery persisted for women with multiples, though the association was dependent on mode of delivery. Conclusions. Women with multiple gestations are at increased risk for infectious morbidity identified at the time of delivery. This association was diminished among women who had a cesarean suggesting that operative delivery is not responsible for this association.

Grotegut, Chad A.; Heine, R. Phillips

2015-01-01

441

A Multiple Criteria and Multiple Constraints Mathematical Programming Model for Classification  

NASA Astrophysics Data System (ADS)

Mathematical programming has been widely used in data classification. A general strategy to build classifiers is to optimize a global objective function such as the square-loss function. However, in many real life situations, optimizing only one single objective function can hardly achieve a satisfactory classifier. Thus a series of models based on multiple criteria mathematical programming (MCMP) have been proposed recently, such as the multiple criteria linear programming (MCLP) model and the linear discriminant Analysis (LDA) model. In this paper, we argue that due to the inherent complexity of the real world data, multiple criteria mathematical programming may be also inadequate to identify a genuine classification boundary. Under this observation, we present a multiple criteria multiple constraints mathematical programming (MC2MP) model for classification. More specifically, we extend a most recent multiple criteria programming model, the MEMBV model, into a multiple constraints MEMBV model.

Zhang, Peng; Tian, Yingjie; Zhang, Dongling; Zhu, Xingquan; Shi, Yong

442

Autobiographical Memory in a Case of Multiple Personality Disorder  

Microsoft Academic Search

Previous research on multiple personality disorder (MPD) has been concerned with between-personalities amnesia, and little attention has been paid to within-personality memory function. This study examined the autobiographical memory of a multiple personality patient, I.C., with cueing procedures that have proven useful in previous studies of normal and abnormal memory. Results indicated that I.C. was able to retrieve autobiographical episodes

Daniel L. Schacter; John F. Kihlstrom; Lucy Canter Kihlstrom; Michael B. Berren

1989-01-01

443

Multiple faces elicit augmented neural activity  

PubMed Central

How do our brains respond when we are being watched by a group of people?Despite the large volume of literature devoted to face processing, this question has received very little attention. Here we measured the effects on the face-sensitive N170 and other ERPs to viewing displays of one, two and three faces in two experiments. In Experiment 1, overall image brightness and contrast were adjusted to be constant, whereas in Experiment 2 local contrast and brightness of individual faces were not manipulated. A robust positive-negative-positive (P100-N170-P250) ERP complex and an additional late positive ERP, the P400, were elicited to all stimulus types. As the number of faces in the display increased, N170 amplitude increased for both stimulus sets, and latency increased in Experiment 2. P100 latency and P250 amplitude were affected by changes in overall brightness and contrast, but not by the number of faces in the display per se. In Experiment 1 when overall brightness and contrast were adjusted to be constant, later ERP (P250 and P400) latencies showed differences as a function of hemisphere. Hence, our data indicate that N170 increases its magnitude when multiple faces are seen, apparently impervious to basic low-level stimulus features including stimulus size. Outstanding questions remain regarding category-sensitive neural activity that is elicited to viewing multiple items of stimulus categories other than faces. PMID:23785327

Puce, Aina; McNeely, Marie E.; Berrebi, Michael E.; Thompson, James C.; Hardee, Jillian; Brefczynski-Lewis, Julie

2013-01-01

444

Multiple faces elicit augmented neural activity.  

PubMed

How do our brains respond when we are being watched by a group of people?Despite the large volume of literature devoted to face processing, this question has received very little attention. Here we measured the effects on the face-sensitive N170 and other ERPs to viewing displays of one, two and three faces in two experiments. In Experiment 1, overall image brightness and contrast were adjusted to be constant, whereas in Experiment 2 local contrast and brightness of individual faces were not manipulated. A robust positive-negative-positive (P100-N170-P250) ERP complex and an additional late positive ERP, the P400, were elicited to all stimulus types. As the number of faces in the display increased, N170 amplitude increased for both stimulus sets, and latency increased in Experiment 2. P100 latency and P250 amplitude were affected by changes in overall brightness and contrast, but not by the number of faces in the display per se. In Experiment 1 when overall brightness and contrast were adjusted to be constant, later ERP (P250 and P400) latencies showed differences as a function of hemisphere. Hence, our data indicate that N170 increases its magnitude when multiple faces are seen, apparently impervious to basic low-level stimulus features including stimulus size. Outstanding questions remain regarding category-sensitive neural activity that is elicited to viewing multiple items of stimulus categories other than faces. PMID:23785327

Puce, Aina; McNeely, Marie E; Berrebi, Michael E; Thompson, James C; Hardee, Jillian; Brefczynski-Lewis, Julie

2013-01-01

445

Multiple health behaviours: overview and implications  

PubMed Central

Background More remains unknown than known about how to optimize multiple health behaviour change. Methods After reviewing the prevalence and comorbidities among major chronic disease risk behaviours for adults and youth, we consider the origins and applicability of high-risk and population strategies to foster multiple health behaviour change. Results Findings indicate that health risk behaviours are prevalent, increase with age and co-occur as risk behaviour clusters or bundles. Conclusions We conclude that both population and high-risk strategies for health behaviour intervention are warranted, potentially synergistic and need intervention design that accounts for substitute and complementary relationships among bundled health behaviours. To maximize positive public health impact, a pressing need exists for bodies of basic and translational science that explain health behaviour bundling. Also needed is applied science that elucidates the following: (1) the optimal number of behaviours to intervene upon; (2) how target behaviours are best selected (e.g. greatest health impact; patient preference or positive effect on bundled behaviours); (3) whether to increase healthy or decrease unhealthy behaviours; (4) whether to intervene on health behaviours simultaneously or sequentially and (5) how to achieve positive synergies across individual-, group- and population-level intervention approaches. PMID:22363028

Spring, Bonnie; Moller, Arlen C.; Coons, Michael J.

2012-01-01

446

Learning multiple routes in homing pigeons.  

PubMed

The aerial lifestyle of central-place foraging birds allows wide-ranging movements, raising fundamental questions about their remarkable navigation and memory systems. For example, we know that pigeons (Columba livia), long-standing models for avian navigation, rely on individually distinct routes when homing from familiar sites. But it remains unknown how they cope with the task of learning several routes in parallel. Here, we examined how learning multiple routes influences homing in pigeons. We subjected groups of pigeons to different training protocols, defined by the sequence in which they were repeatedly released from three different sites, either sequentially, in rotation or randomly. We observed that pigeons from all groups successfully developed and applied memories of the different release sites (RSs), irrespective of the training protocol, and that learning several routes in parallel did not impair their capacity to quickly improve their homing efficiency over multiple releases. Our data also indicated that they coped with increasing RS uncertainty by adjusting both their initial behaviour upon release and subsequent homing efficiency. The results of our study broaden our understanding of avian route following and open new possibilities for studying learning and memory in free-flying animals. PMID:24718093

Flack, Andrea; Guilford, Tim; Biro, Dora

2014-01-01

447

Integrated-optical approaches to matrix multiplication  

NASA Technical Reports Server (NTRS)

The solution of matrix equations is essential to carrying out a large variety of control algorithms and to reducing certain types of data such as the output of a multispectral sensor array. Optical techniques and, in particular, integrated-optical circuits (IOC's) can provide compact, low-power devices for performing the mitrix multiplications necessary for the solution of these problems. A specific IOC for performing vector-matrix multiplication and several approaches to the design of IOC's for matrix-matrix multiplication will be discussed.

Verber, C. M.; Kenan, R. P.

1984-01-01

448

Multiple-fold clustered processor mesh array  

NASA Astrophysics Data System (ADS)

The multiple-fold clustered processor mesh array is a triangular organization of clustered processing elements. This multiple-fold array maintains functional equivalence to the nearest neighbor mesh computer with uni-directional interprocessor communications, but with half the number of connection wires. In addition, the connectivity of the multiple-folded organization is superior to the standard square mesh due to the improved connectivity between the clustered processors. One of the primary application areas targeted is High Performance Architectures for image processing.

Pechanek, Gerald G.; Vassiliadis, Stamatis; Delgado, Jose G.

449

Multiple-fold clustered processor mesh array  

NASA Technical Reports Server (NTRS)

The multiple-fold clustered processor mesh array is a triangular organization of clustered processing elements. This multiple-fold array maintains functional equivalence to the nearest neighbor mesh computer with uni-directional interprocessor communications, but with half the number of connection wires. In addition, the connectivity of the multiple-folded organization is superior to the standard square mesh due to the improved connectivity between the clustered processors. One of the primary application areas targeted is High Performance Architectures for image processing.

Pechanek, Gerald G.; Vassiliadis, Stamatis; Delgado, Jose G.

1993-01-01

450

Efficient Multiplication of Polynomials on Graphics Hardware  

NASA Astrophysics Data System (ADS)

We present the algorithm to multiply univariate polynomials with integer coefficients efficiently using the Number Theoretic transform (NTT) on Graphics Processing Units (GPU). The same approach can be used to multiply large integers encoded as polynomials. Our algorithm exploits fused multiply-add capabilities of the graphics hardware. NTT multiplications are executed in parallel for a set of distinct primes followed by reconstruction using the Chinese Remainder theorem (CRT) on the GPU. Our benchmarking experiences show the NTT multiplication performance up to 77 GMul/s. We compared our approach with CPU-based implementations of polynomial and large integer multiplication provided by NTL and GMP libraries.

Emeliyanenko, Pavel

451

Multiple-patient simulations: guidelines and examples.  

PubMed

Multiple-patient simulations may be used to promote the development of leadership skills as well as patient care management. Multiple-patient simulations create opportunities that mimic real interactions encountered in clinical practice. In addition to promoting the development of these essential skills among students, these simulations also meet the needs of new graduate nurses. The purpose of this article is to provide educators with guidelines on how to create and implement a multiple-patient simulation and examples for application. PMID:25330269

Horsley, Trisha Leann; Bensfield, Linda A; Sojka, Sandra; Schmitt, Ann

2014-01-01

452

Multiple eruptive keratoacanthomas arising in a tattoo.  

PubMed

Keratoacanthomas are rapidly growing, keratinizing, epithelial neoplasms that tend to spontaneously involute and are rarely multiple or eruptive. There is still disagreement on whether or not this condition is a malignancy or a benign epidermal neoplasm; nevertheless, its appearance on tattoos has been reported in rare instances. When waiting for spontaneous involution is not an option, surgery is the preferred treatment. Other therapeutic modalities used for the treatment of this condition include radiotherapy; cryotherapy; laser therapy; and multiple intralesional, topical, and systemic agents. The authors report a patient who developed multiple, eruptive keratoacanthomas in the red ink portions of a tattoo and was successfully treated with acitretin. PMID:20725558

Vitiello, Magalys; Echeverria, Begoña; Romanelli, Paolo; Abuchar, Adriana; Kerdel, Francisco

2010-07-01

453

Detection and location of multiple events by MARS. Final report. [Multiple Arrival Recognition System  

SciTech Connect

Seismic data from two explosions was processed using the Systems Science and Software MARS (Multiple Arrival Recognition System) seismic event detector in an effort to determine their relative spatial and temporal separation on the basis of seismic data alone. The explosions were less than 1.0 kilometer apart and were separated by less than 0.5 sec in origin times. The seismic data consisted of nine local accelerograms (r < 1.0 km) and four regional (240 through 400 km) seismograms. The MARS processing clearly indicates the presence of multiple explosions, but the restricted frequency range of the data inhibits accurate time picks and hence limits the precision of the event location.

Wang, J.; Masso, J.F.; Archambeau, C.B.; Savino, J.M.

1980-09-01

454

Use of Multiplicative Commutativity by School Children and Street Sellers.  

ERIC Educational Resources Information Center

Analyzes the use of the commutative property for solving multiplication problems by children who learn about multiplication in schools and by street vendors who solve multiplication problem through repeated addition. Concludes that the use of commutativity to solve multiplication problems is closely related to the use of multiplication. Contains…

Schliemann, Analucia D.; Araujo, Claudia; Cassunde, Maria Angela; Macedo, Suzana; Niceas, Lenice

1998-01-01

455

Multiple mice tracking using Microsoft Kinect  

E-print Network

Mouse tracking is integral to any attempt to automate mouse behavioral analysis in neuroscience. Systems that rely on vision have successfully tracked a single mouse in one cage[10], but when attempting to track multiple ...

Wang, Chun-Kai, M. Eng. Massachusetts Institute of Technology

2013-01-01

456

Improving the quality of multiple sequence alignment  

E-print Network

Multiple sequence alignment is an important bioinformatics problem, with applications in diverse types of biological analysis, such as structure prediction, phylogenetic analysis and critical sites identification. In recent years, the quality...

Lu, Yue

2009-05-15

457

Multiple sclerosis: Experimental and clinical aspects  

SciTech Connect

This book discusses the experimental and clinical aspects of multiple sclerosis. Specifically discussed are - Association of Epstein Barr Virus with pathology of central nervous system; immunology of viruses; and immunosuppression.

Scheinberg, L.; Raine, C.S.

1984-01-01

458

Scabies - Multiple Languages: MedlinePlus  

MedlinePLUS

... please enable JavaScript. Scabies - Multiple Languages Amharic (amarunya) Oromo (Afaan Oromo) Spanish (español) Amharic (amarunya) Pubic Lice ("Crabs") and ... English amarunya (Amharic) PDF Minnesota Department of Health Oromo (Afaan Oromo) Pubic Lice ("Crabs") and Scabies English ...

459

Multiplicative interaction in network meta-analysis.  

PubMed

Meta-analysis of a set of clinical trials is usually conducted using a linear predictor with additive effects representing treatments and trials. Additivity is a strong assumption. In this paper, we consider models for two or more treatments that involve multiplicative terms for interaction between treatment and trial. Multiplicative models provide information on the sensitivity of each treatment effect relative to the trial effect. In developing these models, we make use of a two-way analysis-of-variance approach to meta-analysis and consider fixed or random trial effects. It is shown using two examples that models with multiplicative terms may fit better than purely additive models and provide insight into the nature of the trial effect. We also show how to model inconsistency using multiplicative terms. Copyright © 2014 John Wiley & Sons, Ltd. PMID:25410043

Piepho, Hans-Peter; Madden, Laurence V; Williams, Emlyn R

2015-02-20

460

Allergy - Multiple Languages: MedlinePlus  

MedlinePLUS

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461

Bone Cancer - Multiple Languages: MedlinePlus  

MedlinePLUS

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462

Atrial Fibrillation - Multiple Languages: MedlinePlus  

MedlinePLUS

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463

Acne - Multiple Languages: MedlinePlus  

MedlinePLUS

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464

Animal Bites - Multiple Languages: MedlinePlus  

MedlinePLUS

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465

Anxiety - Multiple Languages: MedlinePlus  

MedlinePLUS

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466

Alzheimer's Caregivers - Multiple Languages: MedlinePlus  

MedlinePLUS

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467

Acne - Multiple Languages: MedlinePlus  

MedlinePLUS

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468

Anal Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

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469

Back Injuries - Multiple Languages: MedlinePlus  

MedlinePLUS

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470

Blood Disorders - Multiple Languages: MedlinePlus  

MedlinePLUS

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471

Botulism - Multiple Languages: MedlinePlus  

MedlinePLUS

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472

Bacterial Infections - Multiple Languages: MedlinePlus  

MedlinePLUS

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473

Brain Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

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474

Bladder Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

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475

Anesthesia - Multiple Languages: MedlinePlus  

MedlinePLUS

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476

Aortic Aneurysm - Multiple Languages: MedlinePlus  

MedlinePLUS

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477

After Surgery - Multiple Languages: MedlinePlus  

MedlinePLUS

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478

Blood Thinners - Multiple Languages: MedlinePlus  

MedlinePLUS

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479

Appendicitis - Multiple Languages: MedlinePlus  

MedlinePLUS

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480

Angioplasty - Multiple Languages: MedlinePlus  

MedlinePLUS

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481

Bone Diseases - Multiple Languages: MedlinePlus  

MedlinePLUS

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482

Anemia - Multiple Languages: MedlinePlus  

MedlinePLUS

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483

Asthma - Multiple Languages: MedlinePlus  

MedlinePLUS

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484

Breast Cancer - Multiple Languages: MedlinePlus  

MedlinePLUS

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485

Acute Bronchitis - Multiple Languages: MedlinePlus  

MedlinePLUS

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486

Aneurysms - Multiple Languages: MedlinePlus  

MedlinePLUS

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487

Anthrax - Multiple Languages: MedlinePlus  

MedlinePLUS

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488

Plague - Multiple Languages: MedlinePlus  

MedlinePLUS

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489

Refractive Errors - Multiple Languages: MedlinePlus  

MedlinePLUS

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490

Spectral analysis of multiple time series  

NASA Technical Reports Server (NTRS)

Application of spectral analysis for mathematically determining relationship of random vibrations in structures and concurrent events in electric circuits, physiology, economics, and seismograms is discussed. Computer program for performing spectral analysis of multiple time series is described.

Dubman, M. R.

1972-01-01

491

Trust Issues with Multiple Personality Clients.  

ERIC Educational Resources Information Center

Discusses development of trust in a counselor and the therapy process by multiple personality disordered (MPD) clients. Offers list of trust statements effective in engendering trust of MPD client toward counselor. (CM)

Finch, Jessie E.

1990-01-01

492

Coronavirus Infections - Multiple Languages: MedlinePlus  

MedlinePLUS

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493

Oil Spills - Multiple Languages: MedlinePlus  

MedlinePLUS

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494

Current therapeutic strategy for multiple myeloma.  

PubMed

This is a review regarding the current therapeutic strategies in the management of multiple myeloma. Due to the introduction of several new effective therapeutic agents, multiple myeloma is one of the most active and changing fields in clinical oncology. Multiple myeloma is caused by the expansion of monoclonal plasma cells and secretion of M-protein (immunoglobulins, Bence Jones protein and free light chain). High-dose chemotherapy supported with autologous peripheral blood stem cells is an effective treatment for the disease. However, multiple myelomas are still difficult to cure and require long-term disease control. In recent years, the introduction of novel drugs (bortezomib, lenalidomide and thalidomide) has improved treatment. PMID:23293370

Suzuki, Kenshi

2013-02-01

495

Multiple Object Tracking in Autism Spectrum Disorders  

E-print Network

Difficulties in visual attention are often implicated in autism spectrum disorders (ASD) but it remains unclear which aspects of attention are affected. Here, we used a multiple object tracking (MOT) task to quantitatively ...

Koldewyn, Kami

496

Pairwise Multiple Comparisons: New Yardstick, New Results.  

ERIC Educational Resources Information Center

Monte Carlo study results show that recently proposed multiple comparison procedures (MCPs) that are not intended to control the familywise error rate had consistently larger true model rates than did familywise error controlling MCPs. (SLD)

Cribbie, Robert A.

2003-01-01

497

Acoustic signal estimation using multiple blind observations  

E-print Network

This thesis proposes two algorithms for recovering an acoustic signal from multiple blind measurements made by sensors (microphones) over an acoustic channel. Unlike other algorithms that use a posteriori probabilistic ...

Lee, Joonsung

2006-01-01

498

Multiple microprocessor systems: what, why, and when  

SciTech Connect

For many applications-especially those requiring diversified computations in real time or high reliability without massive redundancy-multiple micons-especially those requiring diversified computations in real time or high reliability without massive redundancy-multiple microprocessor systems are the logical choice. Multiple microprocessor systems can provide an appropriate solution to the demand for additional computing power to meet new requirements and to support complex applications. To clarify the concept and its associated terminology, this article considers the what, why, and when of multiple microprocessor systems. Aspects that apply to all processors, regardless of size, are presented in general terms. However, since the main interest lies with microprocessor-based systems, aspects that depend on processor power and input/output flexibility are related specifically to microprocessors. 38 references.

Fathi, E.T.; Krieger, M.

1983-03-01

499

New Drugs for Multiple Myeloma Consolidation Therapy  

Cancer.gov

In this trial, newly diagnosed multiple myeloma patients who have undergone induction therapy will be treated with consolidation therapy consisting of dexamethasone and the drug bortezomib, and some will also be randomly assigned to receive a third drug called lenalidomide.

500

Lenalidomide Maintenance Therapy for Multiple Myeloma  

Cancer.gov

In this trial, researchers are exploring whether maintenance therapy with lenalidomide after single autologous stem cell transplantation can slow or prevent the return of multiple myeloma in patients who have undergone induction therapy.