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1

Multiplicity.  

National Technical Information Service (NTIS)

In federal practice, the double jeopardy protection against multiple punishment for the same offense has been described as 'one of the least understood' and 'most frequently litigated' issues. In military practice, the protection operates under the nom-de...

T. L. Herrington

1991-01-01

2

Monitoring Stream Channels and Riparian Vegetation--Multiple Indicators.  

National Technical Information Service (NTIS)

The purpose of Monitoring Stream Channels and Riparian Vegetation Multiple Indicators (or Multiple Indictor Method - MIM) is to provide an efficient and effective approach to monitoring streambanks, stream channels, and riparian vegetation. This protocol ...

E. R. Cowley S. J. Smith T. A. Burton

2007-01-01

3

Small Area Indices of Multiple Deprivation in South Africa  

ERIC Educational Resources Information Center

|This paper presents the Provincial Indices of Multiple Deprivation that were constructed by the authors at ward level using 2001 Census data for each of South Africa's nine provinces. The principles adopted in conceptualising the indices are described and multiple deprivation is defined as a weighted combination of discrete dimensions of…

Noble, Michael; Barnes, Helen; Wright, Gemma; Roberts, Benjamin

2010-01-01

4

Estimating Consistency and Accuracy Indices for Multiple Classifications  

ERIC Educational Resources Information Center

|This article describes procedures for estimating various indices of classification consistency and accuracy for multiple category classifications using data from a single test administration. The estimates of the classification consistency and accuracy indices are compared under three different psychometric models: the two-parameter beta…

Lee, Won-Chan; Hanson, Bradley A.; Brennan, Robert L.

2002-01-01

5

Multiple-Indicator Multilevel Growth Model: A Solution to Multiple Methodological Challenges in Longitudinal Studies  

ERIC Educational Resources Information Center

|This paper described the versatility of the multiple-indicator multilevel (MIML) model in helping to resolve four common challenges in studying growth using longitudinal data. These challenges are (1) how to deal with changes in measurement over time and investigate temporal measurement invariance, (2) how to model residual dependence due to the…

Wu, Amery D.; Liu, Yan; Gadermann, Anne M.; Zumbo, Bruno D.

2010-01-01

6

Constrained multiple indicator kriging using sequential quadratic programming  

NASA Astrophysics Data System (ADS)

Multiple indicator kriging (MIK) is a nonparametric method used to estimate conditional cumulative distribution functions (CCDF). Indicator estimates produced by MIK may not satisfy the order relations of a valid CCDF which is ordered and bounded between 0 and 1. In this paper a new method has been presented that guarantees the order relations of the cumulative distribution functions estimated by multiple indicator kriging. The method is based on minimizing the sum of kriging variances for each cutoff under unbiasedness and order relations constraints and solving constrained indicator kriging system by sequential quadratic programming. A computer code is written in the Matlab environment to implement the developed algorithm and the method is applied to the thickness data.

Soltani-Mohammadi, Saeed; Erhan Tercan, A.

2012-11-01

7

Indicators of Multiplicative Reasoning among Fourth Grade Students  

ERIC Educational Resources Information Center

Many students encounter difficulty in their transition to advanced mathematical thinking. Such difficulty may be explained by a lack of understanding of many concepts taught in early school years, especially multiplicative reasoning. Advanced mathematical thinking depends on the development of multiplicative reasoning. The purpose of this study…

Carrier, James A.

2010-01-01

8

Indicators of Multiple Personality Disorder for the Clinician.  

ERIC Educational Resources Information Center

Multiple personality disorder (MPD) is now recognized as a valid diagnostic category. Occurrence may be higher than previously suspected. While physiological testing of MPD has shown significant differences between the various personalities of individuals in terms of galvanic skin response, electroencephalogram recordings, electrodermal response…

Dalton, Thomas W.

9

Multiple Sclerosis  

MedlinePLUS

MENU Return to Web version Multiple Sclerosis Overview What is multiple sclerosis (MS)? Multiple sclerosis is an autoimmune disease that affects the nervous system. Normally, antibodies produced by ...

10

Learning about Locomotion Patterns: Effective Use of Multiple Pictures and Motion-Indicating Arrows  

ERIC Educational Resources Information Center

This study investigated how enriching visualizations with arrows indicating the motion of objects may help in conveying dynamic information: Multiple static-simultaneous visualizations with motion-indicating arrows were compared with either multiple visualizations without arrows or a single visualization with arrows. Seventy-one students were…

Imhof, Birgit; Scheiter, Katharina; Edelmann, Jorg; Gerjets, Peter

2013-01-01

11

Convergent Evidence Scaling for Multiple Assessment Indicators: Conceptual Issues, Applications, and Technical Challenges  

ERIC Educational Resources Information Center

|The purpose of this article is to present Convergent Evidence Scaling (CES) as an emergent method for combining data from multiple assessment indicators. The CES method combines single-case assessment data by converging data gathered across multiple persons, settings, or measures, thereby providing an overall criterion-referenced outcome on which…

Busse, R. T.; Elliott, Stephen N.; Kratochwill, Thomas R.

2010-01-01

12

Aggregation Across Multiple Indicators Improves the Detection of Malingering: Relationship to Likelihood Ratios  

Microsoft Academic Search

Recent literature shows that aggregating across multiple symptom validity test (SVT) failures increases the probability of malingering over use of one indicator alone, supporting the criteria proposed by Slick, Sherman, and Iverson (1999) that require multiple sources of evidence for diagnosis of malingering. The present study reanalyzes with likelihood ratios data previously published by Larrabee (2003a) on litigants with definite

Glenn J. Larrabee

2008-01-01

13

Multiple confidence estimates as indices of eyewitness memory.  

PubMed

Eyewitness identification decisions are vulnerable to various influences on witnesses' decision criteria that contribute to false identifications of innocent suspects and failures to choose perpetrators. An alternative procedure using confidence estimates to assess the degree of match between novel and previously viewed faces was investigated. Classification algorithms were applied to participants' confidence data to determine when a confidence value or pattern of confidence values indicated a positive response. Experiment 1 compared confidence group classification accuracy with a binary decision control group's accuracy on a standard old-new face recognition task and found superior accuracy for the confidence group for target-absent trials but not for target-present trials. Experiment 2 used a face mini-lineup task and found reduced target-present accuracy offset by large gains in target-absent accuracy. Using a standard lineup paradigm, Experiments 3 and 4 also found improved classification accuracy for target-absent lineups and, with a more sophisticated algorithm, for target-present lineups. This demonstrates the accessibility of evidence for recognition memory decisions and points to a more sensitive index of memory quality than is afforded by binary decisions. PMID:18729714

Sauer, James D; Brewer, Neil; Weber, Nathan

2008-08-01

14

Multiplication Fun  

NSDL National Science Digital Library

Play to following games to pracitce your muliplicaiton tables. Hit a Home Run! Start with Multiplication Baseball (Easy). Once your have beat this team try to beat Multiplication Baseball (Medium). When you beat the first two teams try to beat this challanging team Multiplication Baseball (Hard) Learn your multiplication facts by playing Multiplication Flash Fun ...

Young, Mrs.

2007-10-25

15

Multiple Sclerosis  

MedlinePLUS

NINDS Multiple Sclerosis Information Page Clinical Trials Trial of Idebenone in People with Primary Progressive Multiple Sclerosis This trial evaluates ... Trials Organizations Additional resources from MedlinePlus What is Multiple Sclerosis? An unpredictable disease of the central nervous system, ...

16

Multiplication table  

NSDL National Science Digital Library

Help learn First learn go over your Learn The Multiplication table now get some extra help Learn The Multiplication table have fun Learn The multiplication table with games good luck practice test pre test pre test final test ...

Bgross

2011-04-14

17

Control, compare and communicate: designing control charts to summarise efficiently data from multiple quality indicators  

PubMed Central

?? Summarising the complex data generated by multiple cross sectional quality indicators in a way that patients, clinicians, managers and policymakers find useful is challenging. A common approach is aggregation to create summary measures such as star ratings and balanced score cards, but these may conceal the detail needed to focus quality improvement. We propose an alternative way of summarising and presenting multiple quality indicators, suitable for use for quality improvement and governance. This paper discusses (1) control charts for repeated measurements of single processes as used in industrial statistical process control (SPC); (2) control charts for cross sectional comparison of many institutions for a single quality indicator (rarely used in industry but commonly proposed for health care); and (3) small multiple graphics which combine control chart signal extraction with efficient graphical presentations for multiple indicators.

Guthrie, B; Love, T; Fahey, T; Morris, A; Sullivan, F

2005-01-01

18

Multiplication Maddness!  

NSDL National Science Digital Library

Review your multiplication skills with these fun and exciting games! To excercise your brain, start with a review of your multiplication facts with Matching Multiplication! Step up to the plate and use your best swing! It\\'s time to play Batter s Up Baseball! Battle through the multiplication problems to save the princess. Begin your journey of Castle Quest! ...

Morgan, Ms.

2008-04-03

19

Multiplication Mania!  

NSDL National Science Digital Library

These assignments will help you practice your multiplication facts. Work through these multiplication facts. Click on each link and scroll down past the red box to the orange box. Click on \\"Start Multiplication\\". After you type in your answer click on the \\"Check\\" box to check your answer. 1. Practice your multiplication facts 0-3. ...

Packard, Mrs.

2005-10-25

20

Procedures for Computing Classification Consistency and Accuracy Indices with Multiple Categories. ACT Research Report Series.  

ERIC Educational Resources Information Center

|This paper describes procedures for estimating various indices of classification consistency and accuracy for multiple category classifications using data from a single test administration. The estimates of the classification consistency and accuracy indices are compared under three different psychometric models: the two-parameter beta binomial,…

Lee, Won-Chan; Hanson, Bradley A.; Brennan, Robert L.

21

Partial order investigation of multiple indicator systems using variance-based sensitivity analysis  

Microsoft Academic Search

Partial order tools can be used in multiple criteria analysis to prioritize and rank a set of objects. In this setting the starting point is generally a matrix Mnxk of k observed indicators on n objects. Given that indicators are measured at least at the ordinal level, from matrix M its corresponding partially ordered set - poset - is set

Paola Annoni; Rainer Brüggemann; Andrea Saltelli

2011-01-01

22

Therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress  

Microsoft Academic Search

This quasi-experiment study examined the therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress. By utilizing drug interventions that reduced cardiovascular distress through changes in the hypertensive indices, previous studies have shown that improvements in life expectancy, lowering of health care costs in later years, and reduction in all-cause mortality were achieved. In fact, individuals without

Emmanuel O. Okereke

2000-01-01

23

Single and Multiple Indicators of Physical Attractiveness and Psychosocial Behaviors among Young Adolescents.  

ERIC Educational Resources Information Center

Examined relations among several indicators of physical attractiveness (PA): height, weight, and triceps skinfold thickness. Appraised whether multiple PA indicators accounted for more variation in measures of psychosocial functioning than did single PA indexes. Facial attractiveness was the most frequent statistically significant predictor of…

Perkins, Daniel F.; Lerner, Richard M.

1995-01-01

24

Multiple sclerosis  

MedlinePLUS

Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord ( central nervous system ). ... Multiple sclerosis (MS) affects women more than men. The disorder is most commonly diagnosed between ages 20 and ...

25

Multiple Sclerosis  

MedlinePLUS

Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the ... disease, which happens when your body attacks itself. Multiple sclerosis affects women more than men. It often begins ...

26

Multiple Sclerosis  

MedlinePLUS

... may be reprinted for personal, noncommercial use only. Multiple sclerosis By Mayo Clinic staff Original Article: http://www.mayoclinic.com/health/multiple-sclerosis/DS00188 Definition Symptoms Causes Risk factors Complications Preparing ...

27

Multiple Sampling.  

National Technical Information Service (NTIS)

The report presents a computer program designed for use in the development of up to seven step multiple sampling plans. Fixed lot sampling using attributes is discussed for single, double, and multiple sampling approaches. The paper presents some advantag...

J. G. Gilley

1973-01-01

28

Multiple Myeloma  

Center for Drug Evaluation (CDER)

Text Version... Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM) ... Page 13. Smoldering Multiple Myeloma • Serum M-spike ? 3 g/dl ... More results from www.fda.gov/downloads/drugs/developmentapprovalprocess

29

Multiplication Facts  

NSDL National Science Digital Library

You are going to play fun games to practice your multiplication facts. Help Larry figure out how much each person owes for his lemonade and work on your Multiplication Facts. Figure out the prices for 5 people. It\\'s multiplication, it\\'s bingo...no, its MATHO! Play two games of Matho and work on your multiplication. Are you a math Magician? Find out by playing two rounds of this game! Become a ...

Pocock, Mrs.

2006-10-26

30

How teams use indicators for quality improvement - A multiple-case study on the use of multiple indicators in multidisciplinary breast cancer teams.  

PubMed

A crucial issue in healthcare is how multidisciplinary teams can use indicators for quality improvement. Such teams have increasingly become the core component in both care delivery and in many quality improvement methods. This study aims to investigate the relationships between (1) team factors and the way multidisciplinary teams use indicators for quality improvement, and (2) both team and process factors and the intended results. An in-depth, multiple-case study was conducted in the Netherlands in 2008 involving four breast cancer teams using six structure, process and outcome indicators. The results indicated that the process of using indicators involves several stages and activities. Two teams applied a more intensive, active and interactive approach as they passed through these stages. These teams were perceived to have achieved good results through indicator use compared to the other two teams who applied a simple control approach. All teams experienced some difficulty in integrating the new formal control structure, i.e. measuring and managing performance, in their operational task, and in using their 'new' managerial task to decide as a team what and how to improve. Our findings indicate the presence of a network of relationships between team factors, the controllability and actionability of indicators, the indicator-use process, and the intended results. PMID:24034953

Gort, Marjan; Broekhuis, Manda; Regts, Gerdien

2013-06-15

31

Multiplication Rocks!  

NSDL National Science Digital Library

Play these three games to practice your multiplication facts and have fun. Who Want\\'s to be a Mathionaire? Who Want s to be a Mathionaire? Play Multiplication Matho three times and see if you can get less errors every time. Multiplication Matho Play Lemonade Larry three times. Lemonade Larry (Math) ...

Hyde, Mrs.

2006-10-26

32

Patent Quality and Research Productivity: Measuring Innovation with Multiple Indicators &ast  

Microsoft Academic Search

We analyse the determinants of the decline in research productivity using panel data on manufacturing firms in the US for the period 1980–93. We focus on three factors: the level of demand, the quality of patents and technological exhaustion. We develop an index of patent ‘quality’ using detailed patent information and show that using multiple indicators substantially reduces the measured

Jean O. Lanjouw; Mark Schankerman

2004-01-01

33

Gender and Perceived Illness Severity: Differential Indicators of Employment Concerns for Adults with Multiple Sclerosis?  

ERIC Educational Resources Information Center

Although research has indicated a link between gender and perceived illness severity and the employment status of people with multiple sclerosis (MS), it has not addressed questions regarding the relationship between those variables and specific types of employment concerns. In this study, a sample of 1,310 adults with MS replied to a mail survey…

Roessler, Richard T.; Turner, Ronna C.; Robertson, Judith L.; Rumrill,Phillip D.

2005-01-01

34

Discovering Indices of Contingency Awareness in Adults with Multiple Profound Disabilities  

ERIC Educational Resources Information Center

|Two studies were conducted to examine parameters of social attention in contingency awareness training using switch activation with individuals who had multiple profound disabilities. Study 1 compared leisure devices and social attention as reinforcing stimuli with 5 individuals. Results indicated the reinforcing qualities of social attention…

Saunders, Richard R.; Saunders, Muriel D.; Struve, Brittany; Munce, Abbie L.; Olswang, Lesley B.; Dowden, Patricia A.; Klasner, Estelle R.

2007-01-01

35

Increasing Indices Of Happiness Among People With Profound Multiple Disabilities: A Program Replication And Component Analysis  

Microsoft Academic Search

We replicated a program to increase indices of happiness among people with profound multiple disabilities and conducted a component analysis of the program. The program involved presentation and contingent withdrawal of stimuli that had been identified as preferred based on preference assessments and staff opinion. The program was imple- mented with 3 adult students and was accompanied by increased happiness

C Green; S Gardner; DENNIS H. REID

1997-01-01

36

Multiple Correlation versus Multiple Regression.  

ERIC Educational Resources Information Center

|Describes differences between multiple correlation analysis (MCA) and multiple regression analysis (MRA), showing how these approaches involve different research questions and study designs, different inferential approaches, different analysis strategies, and different reported information. (SLD)|

Huberty, Carl J.

2003-01-01

37

Multiplication Mania!  

NSDL National Science Digital Library

Fun games to practice your multiplication facts! Need a refreshing break? Come on over to the lemonade stand...Lemonade Stand At the beach, you can swim, sun, and practice your multiplication facts...Beach Multiplication How fast are you? Click here to...Race the Clock Do you have your spacesuit and astronaut food, are you ready for your...Mission to the Moon ...

Hoeman, Ms.

2008-09-18

38

Multiplication Matho  

NSDL National Science Digital Library

This site has students practice their multiplication facts. They compete against the clock while picking the correct response from numerous choices. Student have Matho when they get five colored snakes in a row.

A + Math

2007-12-12

39

Multiplication Madness  

NSDL National Science Digital Library

Have fun practicing and reviewing your times tables! I am sure you are thirsty for some math, so take a visit to the Multiplication Lemonade Stand! Now why don\\'t you see How Fast Can You Multiply?! Now that you\\'ve raced to the finish, take a trip to Beach Multiplication! Multiply your way through space in your very own MULTIFLYER! How about a game of math-bingo, or Matho? Defend the space ...

Chase, Ms.

2008-09-18

40

Multiplication Mania  

NSDL National Science Digital Library

Brush up on your multiplication skills with these fun games. Math Magician Let\\'s see how you can work your math magic! Choose either multiplication or division on Level 1. Once you feel comfortable, move on to Level 2. Multiflyer Play this fun game while learning about space exploration. Batter s Up Baseball Take me out to the ball game! Practice your math facts with ...

Thompson, Mrs.

2006-04-01

41

Multiple Myeloma  

Microsoft Academic Search

\\u000a Infection is the leading cause of death in patients with multiple myeloma (MM). Over the past decade, significant changes\\u000a have occurred in the spectrum of infections in patients with multiple myeloma, paralleling the changes in the treatment of\\u000a the disease. Although bacteria (particularly Gram-negative organisms) remain the most frequent etiologic agents, invasive\\u000a fungal infections caused by moulds (Aspergillus sp. and

Marcio Nucci; Elias J. Anaissie

42

Therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress  

NASA Astrophysics Data System (ADS)

This quasi-experiment study examined the therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress. By utilizing drug interventions that reduced cardiovascular distress through changes in the hypertensive indices, previous studies have shown that improvements in life expectancy, lowering of health care costs in later years, and reduction in all-cause mortality were achieved. In fact, individuals without risk factors or with low risk factors for cardiovascular disease in young adulthood or middle age were healthier, had a greater life expectancy, and incurred lower health care costs in later years. The hypertensive indices of interest include elevated heart rate (HR), systolic blood pressure (Ps), diastolic blood pressure (PD), mean arterial blood pressure (MABP), pulse pressure (PP), and mechanical disadvantages of the heart MDH. Mechanical disadvantage of the heart is a term that has been developed for the purposes of this study. The alternative hypotheses for this study proposed to show a significant change in the relevant hypertensive indices of cardiovascular distress in volunteers after a minimum of 45 days treatment with multiple nutritional supplements. The target population was all middle-aged (30 to 65 years) volunteer hypertensives in Nigeria (West Africa), who were randomly assigned to either the experimental group or control group, controlling for individuals who were on any form of medication, smokers, alcoholics, and those who were pregnant or on contraceptives. Treatment involved multiple doses of the various vitamins, minerals, essential amino acids, essential fatty acids, and accessory nutrients in their complementary combinations that influence various levels of cardiovascular function. After 45 days of treatment, the differences between the mean sores of the experimental group and control group on Ps, PD, MABP, and PP were found to be statistically significant, at p ? .05 cut-off level for rejecting the null hypothesis for each dependent variable on a one-tailed student's t test. The same results were not demonstrated for HR and MDH. In summary, the therapeutic effects of multiple nutritional supplements on the hypertensive indices of cardiovascular distress could provide a cost-effective, safe, healthy, and reliable way of preventing cardiovascular disease.

Okereke, Emmanuel O.

2000-09-01

43

Using Indicators of Multiple Deprivation to Demonstrate the Spatial Legacy of Apartheid in South Africa  

ERIC Educational Resources Information Center

This paper presents a spatial analysis of multiple deprivation in South Africa and demonstrates that the most deprived areas in the country are located in the rural former homeland areas. The analysis is undertaken using the datazone level South African Index of Multiple Deprivation which was constructed from the 2001 Census. Datazones are a new…

Noble, Michael; Wright, Gemma

2013-01-01

44

Using Indicators of Multiple Deprivation to Demonstrate the Spatial Legacy of Apartheid in South Africa  

ERIC Educational Resources Information Center

|This paper presents a spatial analysis of multiple deprivation in South Africa and demonstrates that the most deprived areas in the country are located in the rural former homeland areas. The analysis is undertaken using the datazone level South African Index of Multiple Deprivation which was constructed from the 2001 Census. Datazones are a new…

Noble, Michael; Wright, Gemma

2013-01-01

45

Multiple primaries in pancreatic cancer patients: indicator of a genetic predisposition?  

Microsoft Academic Search

Background The genetic basis of several familial cancers including breast and colon cancers has been identified recently. The occurrence of multiple cancers in one individual is also suggestive of a genetic predisposition. To evaluate inherited predisposition in pancreatic cancer we compared the clinical data of pancreatic cancer patients with and without multiple primaries as well as the frequency of malignancies

Berthold Gerdes; Andreas Ziegler; Annette Ramaswamy; Peter Langera; Detlef K Bartscha

2000-01-01

46

Monitoring marine recreational water quality using multiple microbial indicators in an urban tropical environment  

PubMed Central

The microbial water quality at two beaches, Hobie Beach and Crandon Beach, in Miami-Dade County, Florida, USA was measured using multiple microbial indicators for the purpose of evaluating correlations between microbes and for identifying possible sources of contamination. The indicator microbes chosen for this study (enterococci, Escherichia coli, fecal coliform, total coliform and C. perfringens) were evaluated through three different sampling efforts. These efforts included daily measurements at four locations during a wet season month and a dry season month, spatially intensive water sampling during low- and high-tide periods, and a sand sampling effort. Results indicated that concentrations did not vary in a consistent fashion between one indicator microbe and another. Daily water quality frequently exceeded guideline levels at Hobie Beach for all indicator microbes except for fecal coliform, which never exceeded the guideline. Except for total coliform, the concentrations of microbes did not change significantly between seasons in spite of the fact that the physical–chemical parameters (rainfall, temperature, pH, and salinity) changed significantly between the two monitoring periods. Spatially intense water sampling showed that the concentrations of microbes were significantly different with distance from the shoreline. The highest concentrations were observed at shoreline points and decreased at offshore points. Furthermore, the highest concentrations of indicator microbe concentrations were observed at high tide, when the wash zone area of the beach was submerged. Beach sands within the wash zone tested positive for all indicator microbes, thereby suggesting that this zone may serve as the source of indicator microbes. Ultimate sources of indicator microbes to this zone may include humans, animals, and possibly the survival and regrowth of indicator microbes due to the unique environmental conditions found within this zone. Overall, the results of this study indicated that the concentrations of indicator microbes do not necessarily correlate with one another. Exceedence of water quality guidelines, and thus the frequency of beach advisories, depends upon which indicator microbe is chosen.

Shibata, Tomoyuki; Solo-Gabriele, Helena M.; Fleming, Lora E.; Elmir, Samir

2008-01-01

47

Comparison of the Multiple-Sample Means with Composite Sample Results for Fecal Indicator Bacteria by Quantitative PCR and Culture  

PubMed Central

Few studies have addressed the efficacy of composite sampling for measuring indicator bacteria by quantitative PCR (qPCR). We compared results from composited samples with multiple-sample means for culture- and qPCR-based water quality monitoring. Results from composited samples for both methods were similarly correlated to multiple-sample means and predicted criteria exceedances equally.

Wymer, Larry J.; Dufour, Alfred P.; Wade, Timothy J.

2012-01-01

48

Assessing the Effects of Stimulation Versus Microswitch-Based Programmes on Indices of Happiness of Students with Multiple Disabilities  

ERIC Educational Resources Information Center

|Background: Stimulation and microswitch-based programmes are considered main strategies to promote indices of happiness in students with multiple disabilities. However, only limited attempts have been made to assess the relative effects of the two programmes. This study conducted such an assessment with seven students with multiple disabilities.…

Lancioni, G. E.; Singh, N. N.; O'Reilly, M. F.; Oliva, D.; Smaldone, A.; Tota, A.; Martielli, G.; Stasolla, F.; Pontiggia, G.; Groeneweg, J.

2006-01-01

49

Associations between multiple indicators of socioeconomic status and obesity in young adult Filipinos vary by gender, urbanicity, and indicator used.  

PubMed

More research is needed on the socio-environmental determinants of obesity in lower- and middle-income countries. We used generalized estimating equations to evaluate the cross-sectional effect of urban residence and multiple individual-level indicators of socioeconomic status (SES) on the odds of overweight or central adiposity in a birth cohort of young adult (mean age 21.5 y) Filipino males (n = 987) and females (n = 819) enrolled in the Cebu Longitudinal Health and Nutrition Survey. Overweight was defined as BMI >/=25 kg/m(2) and central adiposity was defined as a waist circumference >85 cm for males or >80 cm for females. Community-level urbanicity was measured on a continuous scale. Multiple indicators of SES included assets, income, education, and marital status. In the final multivariable models, assets and being married were positively related to overweight and central adiposity in males (P < 0.05), but being married was the only predictor of these outcomes in females. However, once the modifying effects of urban residence were accounted for, assets were positively related to overweight and central adiposity among the most rural women, but not in more urban women. Our results are consistent with a growing body of literature that suggests the relationship between SES and obesity is positive in lower-income contexts and inverse in higher-income contexts, particularly in females. The pattern of relationships we observed suggests that as the Philippines continues to develop economically, the public health impact of obesity will increase similarly to what has been observed in countries further along in their economic transition. PMID:20032487

Dahly, Darren L; Gordon-Larsen, Penny; Popkin, Barry M; Kaufman, Jay S; Adair, Linda S

2009-12-23

50

Deprivation Indices, Population Health and Geography: An Evaluation of the Spatial Effectiveness of Indices at Multiple Scales  

PubMed Central

Area-based deprivation indices (ABDIs) have become a common tool with which to investigate the patterns and magnitude of socioeconomic inequalities in health. ABDIs are also used as a proxy for individual socioeconomic status. Despite their widespread use, comparably less attention has been focused on their geographic variability and practical concerns surrounding the Modifiable Area Unit Problem (MAUP) than on the individual attributes that make up the indices. Although scale is increasingly recognized as an important factor in interpreting mapped results among population health researchers, less attention has been paid specifically to ABDI and scale. In this paper, we highlight the effect of scale on indices by mapping ABDIs at multiple census scales in an urban area. In addition, we compare self-rated health data from the Canadian Community Health Survey with ABDIs at two census scales. The results of our analysis confirm the influence of spatial extent and scale on mapping population health—with potential implications for health policy implementation and resource distribution.

Bell, Nathaniel; Dunn, James R.; Oliver, Lisa

2007-01-01

51

Lattice Multiplication  

NSDL National Science Digital Library

Leonardo Fibonacci's multiplication algorithm arrays the digits of multiplicands along a rectangular lattice. Read an explanation of the technique, see a few worked examples, and watch the method in action with a Java applet. Clicking a little off-center of any digit of a multiplicand (left to increase, right to decrease) instantly changes resulting products and sums throughout the lattice.

Interactive Math Miscellany And Puzzles, Alexander B.

2011-01-01

52

Multiplication Madness!  

NSDL National Science Digital Library

Practice multiplying with these fun math games! Warm up your multiplication skills with Jungle Jim as you help him multiply with the monkeys! Begin with multiplying by 2 and move up. Next, quench your thirst with the Lemonade Game as you help calculate how much money you should get for each cup of lemonade you sell. Use the number keys ...

Schieffer, Miss

2009-04-21

53

Multiplication Madness  

NSDL National Science Digital Library

Get ready for some multplication fun! Test your skills with Go Granny Go!. If you are ready for a challenge, try Jungle Jim goes fishing. Send a knight flying with your knowledge of multiplication facts in Knight Fight! If you are feeling really smart, try Knight Quest. Have some fun with Wack a Mole and Workin Out with Wade! ...

Chase, Ms.

2010-11-12

54

Multiple Sclerosis.  

ERIC Educational Resources Information Center

|This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

Plummer, Nancy; Michael, Nancy, Ed.

55

Multiplication Frenzy  

NSDL National Science Digital Library

You are going to practice your multiplication facts!! Let\\'s travel to the moon! Moon Math!! (Just click on moon math when the page opens.) Time yourself! See how many you can get correct in one minute!! Shoot down the space crafts!! Math Invaders ...

Priola, Ms.

2008-07-12

56

Rectangle Multiplication  

NSDL National Science Digital Library

This interactive Java applet use arrays and three different computational models (Grouping, Common, or Lattice) to help students visualize and understand the process of multiplication of whole numbers. In each method the user drags sliders to adjust the two factors and then observes the resulting changes in the rectangular array and in the respective algorithm and product.

1999-01-01

57

Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment.  

PubMed

Few studies have looked at the potential of using diffusion tensor imaging (DTI) in conjunction with machine learning algorithms in order to automate the classification of healthy older subjects and subjects with mild cognitive impairment (MCI). Here we apply DTI to 40 healthy older subjects and 33 MCI subjects in order to derive values for multiple indices of diffusion within the white matter voxels of each subject. DTI measures were then used together with support vector machines (SVMs) to classify control and MCI subjects. Greater than 90% sensitivity and specificity was achieved using this method, demonstrating the potential of a joint DTI and SVM pipeline for fast, objective classification of healthy older and MCI subjects. Such tools may be useful for large scale drug trials in Alzheimer's disease where the early identification of subjects with MCI is critical. PMID:22384251

O'Dwyer, Laurence; Lamberton, Franck; Bokde, Arun L W; Ewers, Michael; Faluyi, Yetunde O; Tanner, Colby; Mazoyer, Bernard; O'Neill, Desmond; Bartley, Máiréad; Collins, D Rónán; Coughlan, Tara; Prvulovic, David; Hampel, Harald

2012-02-23

58

Long Multiplication  

NSDL National Science Digital Library

This Java applet offers an interactive version of the standard "long" multiplication algorithm. Click any digit of either multiplicand slightly off-center (left to increase, right to decrease) and watch the corresponding products change accordingly. In addition to check-boxes to toggle the appearance of trailing zeros and other display choices, the applet also lets you change bases -- from base 3 to base 36.

Interactive Math Miscellany And Puzzles, Alexander B.

2011-01-01

59

Multiple Reflections  

NSDL National Science Digital Library

This activity on multiple reflections is produced by the International Society for Optical Engineering, the Optical Society of America, and the Association of Universities for Research in Astronomy. Two plane rectangular mirrors, that meet on one edge, produce various reflection patterns. Students learn the relationship between the number of images produced and the orientation of the two mirrors. The site lists all necessary tools and materials and includes numerous helpful photographs and diagrams.

2009-01-13

60

Multiple Regression  

NSDL National Science Digital Library

This resource explains multiple regression and concepts associated with it. These are some of the key concepts addressed: predicted values, residuals, dummy variables, interaction effects, t-test, regression coefficients, correlation, partial correlation, r-squared, adjusted r-squared, multicollinearity, variance-inflation factors, transformation, Cook's distance, validity, Durbin-Watson coefficient. The site features a key concepts section, different assumptions of the models and also frequently asked questions about the contents.

Garson, G. D.

2009-01-23

61

Multiple sclerosis  

PubMed Central

Introduction Multiple sclerosis is the most common cause of neurological disability in young adults. Irreversible disability can occur, but life expectancy is generally not affected. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions aimed at reducing relapse rates and disability in people with multiple sclerosis? What are the effects of interventions to improve symptoms during acute relapse? What are the effects of treatments for fatigue, spasticity, and multidisciplinary care on disability in people with multiple sclerosis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2008 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 68 systematic reviews, RCTs, and observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions In this systematic review, we present information relating to the effectiveness and safety of the following key interventions: amantadine, azathioprine, behaviour modification, botulinum toxin, corticosteroids, exercise, gabapentin, inpatient or outpatient rehabilitation, interferon beta, intrathecal baclofen, intravenous immunoglobulin, methotrexate, mitoxantrone, modafinil, natalizumab, oral drug treatments, parenteral glatiramer acetate, physiotherapy, and plasma exchange.

2009-01-01

62

Large-scale diversity of slope fishes: pattern inconsistency between multiple diversity indices.  

PubMed

Large-scale studies focused on the diversity of continental slope ecosystems are still rare, usually restricted to a limited number of diversity indices and mainly based on the empirical comparison of heterogeneous local data sets. In contrast, we investigate large-scale fish diversity on the basis of multiple diversity indices and using 1454 standardized trawl hauls collected throughout the upper and middle slope of the whole northern Mediterranean Sea (36°3'- 45°7' N; 5°3'W - 28°E). We have analyzed (1) the empirical relationships between a set of 11 diversity indices in order to assess their degree of complementarity/redundancy and (2) the consistency of spatial patterns exhibited by each of the complementary groups of indices. Regarding species richness, our results contrasted both the traditional view based on the hump-shaped theory for bathymetric pattern and the commonly-admitted hypothesis of a large-scale decreasing trend correlated with a similar gradient of primary production in the Mediterranean Sea. More generally, we found that the components of slope fish diversity we analyzed did not always show a consistent pattern of distribution according either to depth or to spatial areas, suggesting that they are not driven by the same factors. These results, which stress the need to extend the number of indices traditionally considered in diversity monitoring networks, could provide a basis for rethinking not only the methodological approach used in monitoring systems, but also the definition of priority zones for protection. Finally, our results call into question the feasibility of properly investigating large-scale diversity patterns using a widespread approach in ecology, which is based on the compilation of pre-existing heterogeneous and disparate data sets, in particular when focusing on indices that are very sensitive to sampling design standardization, such as species richness. PMID:23843962

Gaertner, Jean-Claude; Maiorano, Porza; Mérigot, Bastien; Colloca, Francesco; Politou, Chrissi-Yianna; Gil De Sola, Luis; Bertrand, Jacques A; Murenu, Matteo; Durbec, Jean-Pierre; Kallianiotis, Argyris; Mannini, Alessandro

2013-07-03

63

Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer's Disease  

PubMed Central

The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, tract-based spatial statistics (TBSS) were performed on scans of 40 healthy elders, 19 non-amnestic MCI (MCIna) subjects, 14 amnestic MCI (MCIa) subjects and 9 AD patients. Significantly higher DA was found in MCIna subjects compared to healthy elders in the right posterior cingulum/precuneus. Significantly higher DA was also found in MCIa subjects compared to healthy elders in the left prefrontal cortex, particularly in the forceps minor and uncinate fasciculus. In the MCIa versus MCIna comparison, significantly higher DA was found in large areas of the left prefrontal cortex. For AD patients, the overlap of FA and DR changes and the overlap of FA and MD changes were seen in temporal, parietal and frontal lobes, as well as the corpus callosum and fornix. Analysis of differences between the AD versus MCIna, and AD versus MCIa contrasts, highlighted regions that are increasingly compromised in more severe disease stages. Microstructural damage independent of gross tissue loss was widespread in later disease stages. Our findings suggest a scheme where WM damage begins in the core memory network of the temporal lobe, cingulum and prefrontal regions, and spreads beyond these regions in later stages. DA and MD indices were most sensitive at detecting early changes in MCIa.

O'Dwyer, Laurence; Lamberton, Franck; Bokde, Arun L. W.; Ewers, Michael; Faluyi, Yetunde O.; Tanner, Colby; Mazoyer, Bernard; O'Neill, Des; Bartley, Mairead; Collins, D. Ronan; Coughlan, Tara; Prvulovic, David; Hampel, Harald

2011-01-01

64

Multiple sclerosis  

PubMed Central

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.

Hafler, David A.

2004-01-01

65

Multiple myeloma  

PubMed Central

Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. In this paper, we present a historically focused review of the disease, from the description of the first case in 1844 to the present. The evolution of drug therapy and stem-cell transplantation for the treatment of myeloma, as well as the development of new agents, is discussed. We also provide an update on current concepts of diagnosis and therapy, with an emphasis on how treatments have emerged from a historical perspective after certain important discoveries and the results of experimental studies.

Rajkumar, S. Vincent

2008-01-01

66

Multiple sclerosis  

PubMed Central

Multiple sclerosis (MS) is a multifocal demyelinating disease with progressive neurodegeneration caused by an autoimmune response to self-antigens in a genetically susceptible individual. While the formation and persistence of meningeal lymphoid follicles suggest persistence of antigens to drive the continuing inflammatory and humoral response, the identity of an antigen or infectious agent leading to the oligoclonal expansion of B and T cells is unknown. In this review we examine new paradigms for understanding the immunopathology of MS, present recent data defining the common genetic variants underlying disease susceptibility, and explore how improved understanding of immune pathway disruption can inform MS prognosis and treatment decisions.

Nylander, Alyssa; Hafler, David A.

2012-01-01

67

Adolescent Non-Involvement in Multiple Risk Behaviors: An Indicator of Successful Development?  

Microsoft Academic Search

Based on the conceptualization of successful development as the joint maximization of desirable outcomes and minimization of undesirable outcomes (Baltes, 1997), the present study examined connections between adolescent non-involvement in multiple risk behaviors and positive developmental status. Results from a survey of 7290 high school students were used to define four profiles of risk behavior involvement (complete non-involvement, some involvement,

Teena Willoughby; Heather Chalmers; Michael A. Busseri; Sandra Bosacki; Diane Dupont; Zopito Marini; Linda Rose-Krasnor; Stan Sadava; Anthony Ward; Vera Woloshyn

2007-01-01

68

Multiple Personality Disorder: A Risk Indicator, Diagnostic Marker and Psychiatric Outcome for Severe Child Abuse  

Microsoft Academic Search

Recent studies suggest that multiple personality disorder (MPD) is not as rare as previously believed. Indeed, it may represent a relatively common (as many as 25% of cases) outcome of severe physical and sexual abuse of children. Because diagnosis and treatment offer the best prognosis, it is important for the pediatric clinician to become familiar with both the at risk

Barbara Y. Whitman; Wayne Munkel

1991-01-01

69

Assessment of lung injury in the adult respiratory distress syndrome using multiple indicator dilution curves  

SciTech Connect

To assess its usefulness as an index of lung injury in critically ill patients with respiratory failure, the lung microvascular permeability surface area product for urea (/sup 14/C-PSu) was measured using a multiple radioisotopic indicator dilution technique in 10 patients with the adult respiratory distress syndrome (ARDS) and in a control population of 5 patients without ARDS. The mean values for /sup 14/C-PSu and for extravascular lung water (EVLW) were both significantly elevated in patients with ARDS compared with those in control patients (/sup 14/C-PSu: 18.7 +/- 4.4 versus 7.6 +/- 0.7, p less than 0.05; EVLW: 676 +/- 55 versus 269 +/- 53, p less than 0.001); /sup 14/C-PSu and EVLW were significantly correlated (R = 0.52, p less than 0.001). In the patients with ARDS, /sup 14/C-PSu and oxygenation, assessed as the alveolar-arterial oxygen difference, did not appear to be correlated. Repeated measurements of /sup 14/C-PSu were variable in the 3 control patients in whom 4 or more measurements were obtained (SD = 50, 57, and 54% of the mean values, respectively); /sup 14/C-PSu did not predict clinical outcome assessed by survival of individual patients with ARDS. These data suggest that measurement of /sup 14/C-PSu in critically ill patients is a clinically applicable parameter that reflects the degree of microvascular injury in groups of patients. However, our study did not indicate a clear advantage of /sup 14/C-PSu over EVLW in assessing lung injury in this patient population. The variability in /sup 14/C-PSu control patients also suggests that directional changes in /sup 14/C-PSu, as a measure of changes in the degree of lung microvascular dysfunction, should be interpreted with caution.

Rinaldo, J.E.; Borovetz, H.S.; Mancini, M.C.; Hardesty, R.L.; Griffith, B.P.

1986-06-01

70

Multiple myeloma.  

PubMed Central

Multiple myeloma occurs in over 2000 new patients in England and Wales each year. It presents most frequently as bone pain and patients tend to become dehydrated and may develop renal failure. No available treatment is curative, but about two thirds of patients achieve a stable response with low dose combination chemotherapy. Combination chemotherapy including doxorubicin and carmustine with the alkylating agents cyclophosphamide and melphalan achieve a higher stable response rate than conventional treatment with melphalan and prednisone without additional haematological toxicity. These responses are associated with loss of bone pain and patients remain symptom free for months without further treatment. Relapse occurs on average in a little under two years and, though second responses are frequently obtained, the disease eventually becomes refractory. This paper looks at who should be treated and the benefits that may be expected from the treatments available.

MacLennan, I. C.; Drayson, M.; Dunn, J.

1994-01-01

71

Residential construction demand forecasting using economic indicators: a comparative study of artificial neural networks and multiple regression  

Microsoft Academic Search

In recent years, demand for residential construction has been growing rapidly in Singapore. This paper proposes the use of economic indicators to predict demand for residential construction in Singapore. At the same time, two forecasting techniques are applied, namely, Artificial Neural Networks (ANN) and Multiple Regression (MR), the former being a state-of-the-art technique while the latter a conventional one. A

Goh Bee Hua

1996-01-01

72

Effects of Microswitch-Based Programs on Indices of Happiness of Students with Multiple Disabilities: A New Research Evaluation  

ERIC Educational Resources Information Center

|The effects of microswitch-based programs on indices of happiness were evaluated with 9 students who had profound multiple disabilities. Each student received an ABAB sequence in which A represented baseline phases and B, intervention phases. During the latter phases, microswitches were used to enable the students to control preferred…

Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Didden, Robert; Oliva, Doretta; Severini, Laura; Smaldone, Angela; Tota, Alessia; Lamartire, Maria L.

2007-01-01

73

Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis  

PubMed Central

Correlations in spontaneous brain activity provide powerful access to large-scale organizational principles of the CNS. However, making inferences about cognitive processes requires a detailed understanding of the link between these couplings and the structural integrity of the CNS. We studied the impact of multiple sclerosis, which leads to the severe disintegration of the central white matter, on functional connectivity patterns in spontaneous cortical activity. Using a data driven approach based on the strength of a salient pattern of cognitive pathology, we identified distinct networks that exhibit increases in functional connectivity despite the presence of strong and diffuse reductions of the central white-matter integrity. The default mode network emerged as a core target of these connectivity modulations, showing enhanced functional coupling in bilateral inferior parietal cortex, posterior cingulate, and medial prefrontal cortex. These findings imply a complex and diverging relation of anatomical and functional connectivity in early multiple sclerosis and, thus, add an important observation for understanding how cognitive abilities and CNS integrity may be reflected in the intrinsic covariance of functional signals.

Hawellek, David J.; Hipp, Joerg F.; Lewis, Christopher M.; Corbetta, Maurizio; Engel, Andreas K.

2011-01-01

74

Increased serum levels of soluble CD14 indicate stable multiple sclerosis.  

PubMed

The aim of this study was to evaluate a possible role of soluble CD14 (sCD14) in multiple sclerosis (MS). We found that sCD14 serum levels measured by ELISA were higher in MS patients compared to neurological and healthy controls. Within the MS group sCD14 levels were increased in relapsing-remitting and secondary progressive MS compared to primary progressive MS. Furthermore, sCD14 concentrations were increased during stable disease. An increased expression of sCD14 was also detected after treatment with interferon-beta. In summary, we report evidence that serum sCD14 levels are increased in MS and correlate inversely with disease activity in relapsing MS patients. PMID:17046070

Lutterotti, Andreas; Kuenz, Bettina; Gredler, Viktoria; Khalil, Michael; Ehling, Rainer; Gneiss, Claudia; Egg, Robert; Deisenhammer, Florian; Berger, Thomas; Reindl, Markus

2006-10-13

75

Evaluation of the Impact of Alveolar Nitrogen Excretion on Indices Derived from Multiple Breath Nitrogen Washout  

PubMed Central

Background A large body of evidence has now accumulated describing the advantages of multiple breath washout tests over conventional spirometry in cystic fibrosis (CF). Although the majority of studies have used exogenous sulphur hexafluoride (SF6) as the tracer gas this has also led to an increased interest in nitrogen washout tests, despite the differences between these methods. The impact of body nitrogen excreted across the alveoli has previously been ignored. Methods A two-compartment lung model was developed that included ventilation heterogeneity and dead space (DS) effects, but also incorporated experimental data on nitrogen excretion. The model was used to assess the impact of nitrogen excretion on washout progress and accuracy of functional residual capacity (FRC) and lung clearance index (LCI) measurements. Results Excreted nitrogen had a small effect on accuracy of FRC (1.8%) in the healthy adult model. The error in LCI calculated with true FRC was greater (6.3%), and excreted nitrogen contributed 21% of the total nitrogen concentration at the end of the washout. Increasing DS and ventilation heterogeneity both caused further increase in measurement error. LCI was increased by 6–13% in a CF child model, and excreted nitrogen increased the end of washout nitrogen concentration by 24–49%. Conclusions Excreted nitrogen appears to have complex but clinically significant effects on washout progress, particularly in the presence of abnormal gas mixing. This may explain much of the previously described differences in washout outcomes between SF6 and nitrogen.

Nielsen, Niklas; Nielsen, Jorgen G.; Horsley, Alex R.

2013-01-01

76

Reproducibility of multiple breath washout indices in the unsedated preterm neonate.  

PubMed

Multiple breath inert gas washout (MBW) is gaining popularity for measurements of resting lung volume and ventilation inhomogeneity. Test reproducibility is an important determinant of the clinical applicability of diagnostic tests. The between-test reproducibility of variables derived from MBW tests in newborn infants is unknown. We aimed to determine the within-test repeatability and short-term between-test reproducibility of MBW variables in unsedated preterm infants. We hypothesized that measurements obtained within a 3-day interval in clinically stable preterm infants would be reproducible and suitable for use as an objective clinical outcome measurement. In this cross-sectional observational study, clinically stable hospitalized preterm infants whose parents had given informed consent for MBW studies were tested twice within 72 hr during quiet, unsedated sleep. Functional residual capacity (FRC), lung clearance index (LCI), and the first and second to zeroeth moment ratios (M(1):M(0); M(2):M(0)) were computed from MBW traces obtained using a mainstream ultrasonic flowmeter and 4% sulphur hexafluoride (MBW(SF6)). Within-test repeatability and between-test reproducibility were determined. Within-test repeatability (expressed as a coefficient of variability (C(v))) for differences between two and four replicate measurements on the same test occasion, were 9.3% (FRC), 9.0% (LCI), 7.6% (M(1):M(0)), and 15.6% (M(2):M(0)), respectively. The within-test C(v)'s were not statistically different to the between-tests C(v)'s, which were 7.7% (FRC), 10.3% (LCI), 6.1% (M(1):M(0)), and 13.0% (M(2):M(0)), respectively. Among unsedated preterm infants, between-test reproducibility over a 3-day interval was similar to within-test repeatability. The wide limits of agreement may limit the application of these measures to detect a clinically significant change in condition in small preterm infants. PMID:20025050

Sinhal, Sanjay; Galati, John; Baldwin, David N; Stocks, Janet; Pillow, J Jane

2010-01-01

77

Diagnosis of multiple myeloma  

Microsoft Academic Search

Appropriate diagnosis of multiple myeloma is critical for proper initial therapy. This article describes the criteria necessary for the diagnosis of multiple myeloma and differentiates multiple myeloma from smoldering multiple myeloma, monoclonal gammopathy of undetermined significance, other metastatic cancers, and amyloidosis. Semin Oncol 29 (suppl 17):2-4. Copyright 2002, Elsevier Science (USA). All rights reserved.

Robert A. Kyle

2002-01-01

78

Multiple indicators, partially ordered sets, and linear extensions: Multi-criterion ranking and prioritization  

Microsoft Academic Search

This paper is concerned with the question of ranking a finite collection of objects when a suite of indicator values is available for each member of the collection. The objects can be represented as a cloud of points in indicator space, but the different indicators (coordinate axes) typically convey different comparative messages and there is no unique way to rank

G. P. Patil; C. Taillie

2004-01-01

79

Defining, validating, and increasing indices of happiness among people with profound multiple disabilities.  

PubMed Central

In this study we attempted to operationalize, measure, and increase happiness among people with profound disabilities. Happiness indices were defined and observed among 5 individuals. Validation measures indicated that (a) increases in happiness indices were observed when individuals were presented with most preferred stimuli relative to least preferred stimuli, (b) increases in unhappiness indices were observed when they were presented with least preferred relative to most preferred stimuli, and (c) practitioner ratings of participant happiness coincided with observed indices. Subsequently, classroom staff increased happiness indices through presentation and contingent withdrawal of activities. Results suggested that a behavioral approach can enhance happiness as one aspect of quality of life among people with profound disabilities. Research directions are offered that focus on using a behavioral approach to investigate other private events that are important among people with disabilities.

Green, C W; Reid, D H

1996-01-01

80

An Enriched Teaching Program For Reducing Resistance And Indices Of Unhappiness Among Individuals With Profound Multiple Disabilities  

PubMed Central

We evaluated an enriched teaching program for reducing resistance and indices of unhappiness displayed by 3 individuals with profound multiple disabilities during teaching sessions. The program involved presentation of preferred activities before, during, and after each teaching session, discontinuation of identified nonpreferred activities, and a brief break and preferred activity following occurrence of resistance. Implementation of the enriched teaching program was accompanied by reductions in resistance and indices of unhappiness for each participant. Results also indicated no negative impact of the program on participant performance of the teaching steps or staff teaching proficiency. Staff questionnaire responses provided a degree of social validation for the observed changes in that staff reported the participants liked the enriched teaching program more than the traditional teaching process. Directions for future research discussed include identifying critical aspects of the overall program and the potential relation between teaching proficiency and the program's enrichment effectiveness.

2005-01-01

81

Neutron multiplication in beryllium  

SciTech Connect

Integral neutron multiplication experiments have been performed using spherical shells of beryllium metal of 4.6-, 6.99-, 7.87-, 9.38-, 13.8-, and 19.9-cm thickness. Neutron leakage, from {sup 252}Cf and a DT neutron source normalized with an associated particle detector, were measured with a Bonner sphere spectrometer system. The neutron fluence was obtained by processing the room-returned and air-scattered corrected count-rate data with a Bonner sphere spectrum unfolding routine and a weighted Bonner sphere technique. The neutron multiplication was obtained directly by comparing the normalized neutron leakage fluence with and without beryllium present. The neutron leakage spectra were calculated for each shell using the discrete ordinates codes ANISN and ONEDANT with ENDF/B-IV and ENDF/B-V respectively. The cross sections from ENDF/B-V included the most current cross section revisions from the Los Alamos National Laboratory. A comparison of the leakage multiplication, calculated using the two versions of evaluated nuclear data, indicate that corrections have been made to the energy-angle distribution of the secondary neutrons in ENDF/B-V resulting in a lower neutron leakage multiplication for shells greater than 9.38-cm thickness. The measured {sup 252}Cf neutron leakage multiplication is 22% higher than the ANISN-ENDF/B-IV calculated leakage multiplication for the 4.6-cm shell thickness, within 4% for the 6.99-cm thickness, and at least 29% lower than the calculated leakage multiplication for the 19.9-cm shell thickness.

Hartley, R.S.

1987-01-01

82

The multiple semantics hypothesis: Multiple confusions?  

Microsoft Academic Search

In this paper we discuss the issue of multiple versus unitary semantics. We argue that the notion of multiple semantics (as currently articulated) does not, in fact, represent a theory of semantic organisation but is, instead, an arbitrary conjunction of a set of independent assumptions which are either unmotivated or, if motivated, equally compatible with a unitary semantics hypothesis. Furthermore,

Alfonso Caramazza; Argye E. Hillis; Brenda C. Rapp; Cristina Romani

1990-01-01

83

Weighting and Aggregation in Composite Indicator Construction: A Multiplicative Optimization Approach  

ERIC Educational Resources Information Center

|Composite indicators (CIs) have increasingly been accepted as a useful tool for benchmarking, performance comparisons, policy analysis and public communication in many different fields. Several recent studies show that as a data aggregation technique in CI construction the weighted product (WP) method has some desirable properties. However, a…

Zhou, P.; Ang, B. W.; Zhou, D. Q.

2010-01-01

84

A derivation of relationships between two-band vegetation indices from multiple sensors  

Microsoft Academic Search

Relating two spectral vegetation indices (VI) is a fundamental issue for decades in the satellite remote sensing community. Recently, this issue has attracted much attention from varieties of environmental science communities in the context of data continuity by successive satellite sensors which may affect the accuracy of global circulation models. This work introduces a derivation of relationships between two VI's.

Hiroki Yoshioka; H. Yamamoto; T. Miura

2004-01-01

85

Multiple indicator cokriging with application to optimal sampling for environmental monitoring  

NASA Astrophysics Data System (ADS)

A probabilistic solution to the problem of spatial interpolation of a variable at an unsampled location consists of estimating the local cumulative distribution function (cdf) of the variable at that location from values measured at neighbouring locations. As this distribution is conditional to the data available at neighbouring locations it incorporates the uncertainty of the value of the variable at the unsampled location. Geostatistics provides a non-parametric solution to such problems via the various forms of indicator kriging. In a least squares sense indicator cokriging is theoretically the best estimator but in practice its use has been inhibited by problems such as an increased number of violations of order relations constraints when compared with simpler forms of indicator kriging. In this paper, we describe a methodology and an accompanying computer program for estimating a vector of indicators by simple indicator cokriging, i.e. simultaneous estimation of the cdf for K different thresholds, {F(u,zk),k=1,…,K}, by solving a unique cokriging system for each location at which an estimate is required. This approach produces a variance covariance matrix of the estimated vector of indicators which is used to fit a model to the estimated local cdf by logistic regression. This model is used to correct any violations of order relations and automatically ensures that all order relations are satisfied, i.e. the estimated cumulative distribution function, F^(u,zk), is such that: F^(u,zk)?[0,1],?zk,andF^(u,zk)?F^(u,z)forzkindicator cokriging program): a map of the probability of belonging to the specified phase and a map of the associated estimation variances. Optimality is achieved by minimising simultaneously the uncertainty of belonging to the phase and the variance of the error of estimating the uncertainty, thus guaranteeing that maximum information is gained from additional samples.

Pardo-Igúzquiza, Eulogio; Dowd, Peter A.

2005-02-01

86

Mapping tree and shrub leaf area indices in an ombrotrophic peatland through multiple endmember spectral unmixing  

Microsoft Academic Search

Leaf area index (LAI) is an important parameter used by most process-oriented ecosystem models. LAI of forest ecosystems has routinely been mapped using spectral vegetation indices (SVI) derived from remote sensing imagery. The application of SVI-based approaches to map LAI in peatlands presents a challenge, mainly due to peatlands characteristic multi-layer canopy comprising shrubs and open, discontinuous tree canopies underlain

O. Sonnentag; J. M. Chen; D. A. Roberts; J. Talbot; K. Q. Halligan; A. Govind

2007-01-01

87

Multiple Indicators of Children’s Reading Habits and Attitudes: Construct Validity and Cognitive Correlates  

Microsoft Academic Search

Sixty-three 5th-grade children completed daily-activity diaries indicating how they spent their nonschool time for 15 days. From these diaries, estimates of the minutes per day that were spent in various activities were derived. The estimate of book-reading time from the activity diary correlated with new measures of individual differences in exposure to print that use a checklist-with-foils logic and that

Linda Allen; Jim Cipielewski; Keith E. Stanovich

1992-01-01

88

Inter-comparison of drought indicators derived from multiple precipitation datasets in Africa  

NASA Astrophysics Data System (ADS)

This study investigates the potential of implementing different drought indicators to improve drought monitoring capabilities at continental scale. Several global and continental datasets based on re-analysis, gridded observation, and remote sensing data were tested. At regional level the capabilities of each indicator and dataset on five regions on the African continent (Oum er-rbia, Blue Nile, Upper Niger, Limpopo and the Great Horn of Africa) were compared. The five precipitation datasets used were the ERA - Interim reanalysis (0.5°x0.5° resolution from 1979 to 2010), Tropical Rainfall Measuring Mission (TRMM) satellite monthly rainfall product 3B43 (0.25°x0.25° resolution from 1998 to 2010), the Global Precipitation Climatology Centre (GPCC) gridded precipitation dataset V.5 (1°x1° resolution from 1901 to 2010), the Global Precipitation Climatology Project (GPCP) Global Monthly Merged Precipitation Analyses (2.5°x2.5° resolution from 1979 to 2010), and the Climate Prediction Center Merged Analysis of Precipitation (CMAP, 2.5°x2.5° resolution from 1979 to 2010). The set of indicators proposed included Standardized Precipitation index (SPI), Standardized Precipitation-Evaporation Index (SPEI), Standardized Run-off index (SRI), Soil Moisture Anomalies (SMA). A comparison of the annual cycle and monthly precipitation time series shows a general agreement in the timing of the peaks including the Great Horn of Africa where there are two rainy seasons. The main differences are observed thus in the ability to represent the magnitude of the wet seasons and extremes. Moreover, for the areas that are under drought, all the datasets agree with the certain time of onset and recovery but there are sometimes disagreements on the area affected. The agreement between datasets depends on the threshold selected to define the drought conditions. The comparison between SPI estimations suggest that the main sources of uncertainties (due by lack of ground information, estimation algorithms, parameterization of the convection, etc.) are the differences in the precipitation datasets rather than the estimation of the distribution parameters that defines each indicator. Particularly, the estimations of the indicators over Central Africa reflect the high uncertainty present in the precipitation datasets.

Naumann, Gustavo; Dutra, Emanuel; Barbosa, Paulo; Pappenberger, Florian; Wetterhall, Fredrik

2013-04-01

89

Measurement of lung volume by multiple indicator dilution. A simple model and its ramifications.  

PubMed

A simple, idealized rebreathing manoeuvre was simulated numerically on a Hewlett-Packard 9825A desk-top calculator. Approximate imitations were obtained of real-life observations of differences between apparent volumes of distribution of different indicators in the same rebreathing manoeuvre. The simulated patterns of discrepancy depended heavily on the uptake or output profiles which were assumed for carbon dioxide and nitrous oxide during the hypothetical rebreathing manoeuvres. The simulations pointed to the analytical algebraic expressions which explained the simulated patterns of discrepancy. A procedure was devised to correct for the effects of these uptakes or outputs. It depended on considering the mixing of oxygen, nitrogen and argon as if it were occurring in a separate part of the rebreathing system occupied only by these gases. The volume of this notional part would decrease linearly with time at a rate equal to the oxygen consumption. PMID:6370282

Scott, I L; Black, A M; Hahn, C E; Mortimer, A J

1984-04-01

90

Accurate discrimination of conserved coding and non-coding regions through multiple indicators of evolutionary dynamics  

PubMed Central

Background The conservation of sequences between related genomes has long been recognised as an indication of functional significance and recognition of sequence homology is one of the principal approaches used in the annotation of newly sequenced genomes. In the context of recent findings that the number non-coding transcripts in higher organisms is likely to be much higher than previously imagined, discrimination between conserved coding and non-coding sequences is a topic of considerable interest. Additionally, it should be considered desirable to discriminate between coding and non-coding conserved sequences without recourse to the use of sequence similarity searches of protein databases as such approaches exclude the identification of novel conserved proteins without characterized homologs and may be influenced by the presence in databases of sequences which are erroneously annotated as coding. Results Here we present a machine learning-based approach for the discrimination of conserved coding sequences. Our method calculates various statistics related to the evolutionary dynamics of two aligned sequences. These features are considered by a Support Vector Machine which designates the alignment coding or non-coding with an associated probability score. Conclusion We show that our approach is both sensitive and accurate with respect to comparable methods and illustrate several situations in which it may be applied, including the identification of conserved coding regions in genome sequences and the discrimination of coding from non-coding cDNA sequences.

Re, Matteo; Pesole, Graziano; Horner, David S

2009-01-01

91

Complete mitochondrial genome phylogeographic analysis of killer whales (Orcinus orca) indicates multiple species  

PubMed Central

Killer whales (Orcinus orca) currently comprise a single, cosmopolitan species with a diverse diet. However, studies over the last 30 yr have revealed populations of sympatric “ecotypes” with discrete prey preferences, morphology, and behaviors. Although these ecotypes avoid social interactions and are not known to interbreed, genetic studies to date have found extremely low levels of diversity in the mitochondrial control region, and few clear phylogeographic patterns worldwide. This low level of diversity is likely due to low mitochondrial mutation rates that are common to cetaceans. Using killer whales as a case study, we have developed a method to readily sequence, assemble, and analyze complete mitochondrial genomes from large numbers of samples to more accurately assess phylogeography and estimate divergence times. This represents an important tool for wildlife management, not only for killer whales but for many marine taxa. We used high-throughput sequencing to survey whole mitochondrial genome variation of 139 samples from the North Pacific, North Atlantic, and southern oceans. Phylogenetic analysis indicated that each of the known ecotypes represents a strongly supported clade with divergence times ranging from ?150,000 to 700,000 yr ago. We recommend that three named ecotypes be elevated to full species, and that the remaining types be recognized as subspecies pending additional data. Establishing appropriate taxonomic designations will greatly aid in understanding the ecological impacts and conservation needs of these important marine predators. We predict that phylogeographic mitogenomics will become an important tool for improved statistical phylogeography and more precise estimates of divergence times.

Morin, Phillip A.; Archer, Frederick I.; Foote, Andrew D.; Vilstrup, Julia; Allen, Eric E.; Wade, Paul; Durban, John; Parsons, Kim; Pitman, Robert; Li, Lewyn; Bouffard, Pascal; Abel Nielsen, Sandra C.; Rasmussen, Morten; Willerslev, Eske; Gilbert, M. Thomas P.; Harkins, Timothy

2010-01-01

92

Practice Parameters for the Non-Respiratory Indications for Polysomnography and Multiple Sleep Latency Testing for Children  

PubMed Central

Background: Although a level 1 nocturnal polysomnogram (PSG) is often used to evaluate children with non-respiratory sleep disorders, there are no published evidence-based practice parameters focused on the pediatric age group. In this report, we present practice parameters for the indications of polysomnography and the multiple sleep latency test (MSLT) in the assessment of non-respiratory sleep disorders in children. These practice parameters were reviewed and approved by the Board of Directors of the American Academy of Sleep Medicine (AASM). Methods: A task force of content experts was appointed by the AASM to review the literature and grade the evidence according to the American Academy of Neurology grading system. Recommendations For PSG and MSLT Use: PSG is indicated for children suspected of having periodic limb movement disorder (PLMD) for diagnosing PLMD. (STANDARD) The MSLT, preceded by nocturnal PSG, is indicated in children as part of the evaluation for suspected narcolepsy. (STANDARD) Children with frequent NREM parasomnias, epilepsy, or nocturnal enuresis should be clinically screened for the presence of comorbid sleep disorders and polysomnography should be performed if there is a suspicion for sleep-disordered breathing or periodic limb movement disorder. (GUIDELINE) The MSLT, preceded by nocturnal PSG, is indicated in children suspected of having hypersomnia from causes other than narcolepsy to assess excessive sleepiness and to aid in differentiation from narcolepsy. (OPTION) The polysomnogram using an expanded EEG montage is indicated in children to confirm the diagnosis of an atypical or potentially injurious parasomnia or differentiate a parasomnia from sleep-related epilepsy (OPTION) Polysomnography is indicated in children suspected of having restless legs syndrome (RLS) who require supportive data for diagnosing RLS. (OPTION) Recommendations Against PSG Use: Polysomnography is not routinely indicated for evaluation of children with sleep-related bruxism. (STANDARD) Conclusions: The nocturnal polysomnogram and MSLT are useful clinical tools for evaluating pediatric non-respiratory sleep disorders when integrated with the clinical evaluation. Citation: Aurora RN; Lamm CI; Zak RS; Kristo DA; Bista SR; Rowley JA; Casey KR. Practice parameters for the non-respiratory indications for polysomnography and multiple sleep latency testing for children. SLEEP 2012;35(11):1467-1473.

Aurora, R. Nisha; Lamm, Carin I.; Zak, Rochelle S.; Kristo, David A.; Bista, Sabin R.; Rowley, James A.; Casey, Kenneth R.

2012-01-01

93

Employees with Multiple Sclerosis  

MedlinePLUS

... SOAR) at http://AskJAN.org/soar. Information about Multiple Sclerosis (MS) How prevalent is MS? According to the National Multiple Sclerosis Society, approximately 400,000 Americans acknowledge having MS, ...

94

Fatigue and Multiple Sclerosis  

MedlinePLUS

... that JavaScript is enabled in your browser. National Multiple Sclerosis Society Accessibility Navigation: Skip to resource navigation Skip ... MS in Focus is a publication of the Multiple Sclerosis International Federation. Learn More About Fatigue and Coping ...

95

Depression and Multiple Sclerosis  

MedlinePLUS

... various forms is common during the course of multiple sclerosis. In fact, studies have suggested that clinical depression, ... is easy to understand how a diagnosis of multiple sclerosis, a chronic condition with the potential for progressing ...

96

Genetics and Multiple Sclerosis  

MedlinePLUS

... cystic fibrosis. The situation for diseases such as multiple sclerosis is more complicated. Scientists now believe that a person is susceptible to multiple sclerosis only if he or she inherits an unlucky ...

97

Multiple sclerosis - discharge  

MedlinePLUS

Your doctor has told you that you have multiple sclerosis. This disease affects the brain and spinal cord ( ... bladder is not working correctly. Some people with multiple sclerosis need to use a urinary catheter . This is ...

98

National Multiple Sclerosis Society  

MedlinePLUS

... that JavaScript is enabled in your browser. National Multiple Sclerosis Society Accessibility Navigation: Skip to resource navigation Skip ... Primary Content: Programs & Services Events My Content National Multiple Sclerosis Society Latest News In The News Some of ...

99

What Is Multiple Sclerosis?  

MedlinePLUS

... MS >> What is MS? What is MS? Share Multiple sclerosis (MS) is one of the most common diseases ... or lesions) appear as hardened (scar) areas: in multiple sclerosis these scars appear at different times and in ...

100

Multiple Sclerosis and Stress  

MedlinePLUS

... e47-e49 Neurology Beth Rapaport and Steven Karceski Multiple sclerosis and stress This information is current as of ... e47-e49 Neurology Beth Rapaport and Steven Karceski Multiple sclerosis and stress This information is current as of ...

101

Jalyn's Multiplication Mania!  

NSDL National Science Digital Library

Multiplication Games For My Favorite Gillenwater Jalyn Will Love Serving Aliens Lunch! Ms. Gillenwater Will Have Fun With Multiplication In Murbia! When Jalyn Plays This Game She Will Go Bananas! Buy A Pet From Gillenwater s Pet Shop! ...

Huey, Mr.

2011-10-11

102

All About Multiplication  

NSDL National Science Digital Library

This unit consists of four lessons in which students explore several meanings and representations of multiplication, including number lines, sets, arrays, and balance beams. They also learn about the commutative property of multiplication, the results of multiplying by 1 and by 0, and the inverse property of multiplication. Students write story problems and create pictographs. The unit includes activity sheets, assessment ideas, links to related applets, reflective questions for students and teachers, extensions and a bibliography of children's literature with a multiplication focus.

Burton, Grace M.

2000-01-01

103

Multiple sclerosis and pregnancy  

PubMed Central

Multiple sclerosis causes disability in young adults and, like most autoimmune diseases, affects women more commonly than men. The disease can therefore present at a time when many have, or are considering, starting a family. The effect of pregnancy on the outcome of multiple sclerosis is reviewed and the management of pregnant women who have multiple sclerosis is discussed.

Lorenzi, A; Ford, H

2002-01-01

104

Multiple oscillation stabilizing control  

Microsoft Academic Search

This paper presents a strategy that may be used to guide stabilizing control design for multiple oscillations, which are difficult to control using conventional control design procedures. A multiple oscillation phenomena is observed in an example power system. A local bifurcation and an interarea bifurcation develop in an example power system due to multiple bifurcation parameter variations. The dynamic behaviors

Meng Yue; Robert Schlueter; Mohamad A. Azarm; Robert Bari

2004-01-01

105

Multiple-beam amplifiers  

Microsoft Academic Search

The second device type is a low-voltage multiple-beam ex­ tended-interacti on klystron (MB-EIK). Designs are currently being explored for both Ku-and Ka-bands with operation voltages in the range of 2.5 -4.5 kV using permanent magnet focusing. We will present simulations using the NRLISAIC code TESLA that indicate that an output power of greater than 800- W is feasible for aKa-band

Khanh Nguyen; David K. Abe; Edward Wright; Lars Ludeking; Dean Pershing; John Pasour; Igor Chernyavskiy; V. Jabotinski; Baruch Levush

2011-01-01

106

Multiple pulse tea laser  

SciTech Connect

A laser system capable of producing multiple pulses comprising a single optical resonator having multiple discharge regions and multiple sets of electrodes and preionizers. The optical resonator is folded and the beam passes through all of the discharge regions. Since the multiple discharges occur within the same resonator, multiple identical pulses are produced and since the discharge regions are separated, the shock wave and medium inhomogeneity produced by a discharge in one discharge region will not disturb the others. The overall mirror separation and electrode spacing define a Fresnel number suited for single transverse mode operation.

Barnie, J. W.; Rudko, R. I.

1985-03-26

107

Different effects of multiple health status indicators on breast and colorectal cancer screening in a nationally-representative US sample  

PubMed Central

Objective To examine the independent associations between multiple health status indicators and breast and colorectal cancer screening (CRCS) in a national US sample. Study Design and Setting Analysis of cross-sectional data from the 2005 National Health Interview Survey (NHIS) involved 5115 men and 7100 women aged 50 years and older. Measures Health status indicators included: self-reported perceived health status, number of chronic conditions, and functional limitation due to a chronic condition. Individuals were considered adherent to CRCS guidelines if they reported having a home-based fecal occult blood test in the past year or endoscopy in the past 10 years. Women were adherent to breast cancer screening guidelines if they reported having a mammogram in the previous 2 years. Statistical analyses were conducted using SUDAAN software to account for the complex sampling of the NHIS survey. Logistic regression was used to examine associations between each of the health status indicators and screening adherence for CRCS and mammography and to calculate estimated screening rates. Results The three health status indicators were independently and differentially associated with screening adherence. Poor perceived health was associated with lower mammography among women, whereas a greater number of chronic conditions were consistently associated with greater screening. In adjusted analyses, functional limitation was only significantly associated with greater CRCS among women. Conclusions Our analyses included three common indicators of health status and provide new evidence of their complex associations with cancer screening. Future studies must examine the mechanisms by which these indicators influence screening recommendations and adherence among older adults over time.

Deshpande, Anjali D.; McQueen, Amy; Coups, Elliot J.

2011-01-01

108

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of ?-sheets in Alzheimer's ?-amyloid fibrils  

PubMed Central

Senile plaques associated with Alzheimer's disease contain deposits of fibrils formed by 39- to 43-residue ?-amyloid peptides with possible neurotoxic effects. X-ray diffraction measurements on oriented fibril bundles have indicated an extended ?-sheet structure for Alzheimer's ?-amyloid fibrils and other amyloid fibrils, but the supramolecular organization of the ?-sheets and other structural details are not well established because of the intrinsically noncrystalline, insoluble nature of amyloid fibrils. Here we report solid-state NMR measurements, using a multiple quantum (MQ) 13C NMR technique, that probe the ?-sheet organization in fibrils formed by the full-length, 40-residue ?-amyloid peptide (A?1–40). Although an antiparallel ?-sheet organization often is assumed and is invoked in recent structural models for full-length ?-amyloid fibrils, the MQNMR data indicate an in-register, parallel organization. This work provides site-specific, atomic-level structural constraints on full-length ?-amyloid fibrils and applies MQNMR to a significant problem in structural biology.

Antzutkin, Oleg N.; Balbach, John J.; Leapman, Richard D.; Rizzo, Nancy W.; Reed, Jennifer; Tycko, Robert

2000-01-01

109

Multiple emulsions: an overview.  

PubMed

Multiple emulsions are complex polydispersed systems where both oil in water and water in oil emulsion exists simultaneously which are stabilized by lipophillic and hydrophilic surfactants respectively. The ratio of these surfactants is important in achieving stable multiple emulsions. Among water-in-oil-in-water (w/o/w) and oil-in-water-in-oil (o/w/o) type multiple emulsions, the former has wider areas of application and hence are studied in great detail. Formulation, preparation techniques and in vitro characterization methods for multiple emulsions are reviewed. Various factors affecting the stability of multiple emulsions and the stabilization approaches with specific reference to w/o/w type multiple emulsions are discussed in detail. Favorable drug release mechanisms and/or rate along with in vivo fate of multiple emulsions make them a versatile carrier. It finds wide range of applications in controlled or sustained drug delivery, targeted delivery, taste masking, bioavailability enhancement, enzyme immobilization, etc. Multiple emulsions have also been employed as intermediate step in the microencapsulation process and are the systems of increasing interest for the oral delivery of hydrophilic drugs, which are unstable in gastrointestinal tract like proteins and peptides. With the advancement in techniques for preparation, stabilization and rheological characterization of multiple emulsions, it will be able to provide a novel carrier system for drugs, cosmetics and pharmaceutical agents. In this review, emphasis is laid down on formulation, stabilization techniques and potential applications of multiple emulsion system. PMID:17076645

Khan, Azhar Yaqoob; Talegaonkar, Sushama; Iqbal, Zeenat; Ahmed, Farhan Jalees; Khar, Roop Krishan

2006-10-01

110

Secret data communication in a degraded practical multiple input multiple output multiple eavesdropper channel  

Microsoft Academic Search

In this paper, a Gaussian multiple input multiple output multiple eavesdropper (MIMOME) channel is considered where a transmitter communicates to a receiver in the presence of an eavesdropper. We present a technique for determining the secrecy capacity of the multiple input multiple output (MIMO) channel under Gaussian noise. We transform the degraded MIMOME channel into multiple single input multiple output

Mohammad Rakibul Islam

2010-01-01

111

Quantifying and modeling long-range cross correlations in multiple time series with applications to world stock indices.  

PubMed

We propose a modified time lag random matrix theory in order to study time-lag cross correlations in multiple time series. We apply the method to 48 world indices, one for each of 48 different countries. We find long-range power-law cross correlations in the absolute values of returns that quantify risk, and find that they decay much more slowly than cross correlations between the returns. The magnitude of the cross correlations constitutes "bad news" for international investment managers who may believe that risk is reduced by diversifying across countries. We find that when a market shock is transmitted around the world, the risk decays very slowly. We explain these time-lag cross correlations by introducing a global factor model (GFM) in which all index returns fluctuate in response to a single global factor. For each pair of individual time series of returns, the cross correlations between returns (or magnitudes) can be modeled with the autocorrelations of the global factor returns (or magnitudes). We estimate the global factor using principal component analysis, which minimizes the variance of the residuals after removing the global trend. Using random matrix theory, a significant fraction of the world index cross correlations can be explained by the global factor, which supports the utility of the GFM. We demonstrate applications of the GFM in forecasting risks at the world level, and in finding uncorrelated individual indices. We find ten indices that are practically uncorrelated with the global factor and with the remainder of the world indices, which is relevant information for world managers in reducing their portfolio risk. Finally, we argue that this general method can be applied to a wide range of phenomena in which time series are measured, ranging from seismology and physiology to atmospheric geophysics. PMID:21599254

Wang, Duan; Podobnik, Boris; Horvati?, Davor; Stanley, H Eugene

2011-04-25

112

Long-Term Effects of the Family Bereavement Program on Multiple Indicators of Grief in Parentally Bereaved Children and Adolescents  

Microsoft Academic Search

Objectives: This article reports on results from a randomized experimental trial of the effects of the Family Bereavement Program (FBP) on multiple measures of grief experienced by parentally bereaved children and adolescents over a 6-year period. Method: Participants were 244 youths (ages 8–16, mean age = 11.4 years) from 156 families that had experienced the death of a parent. The

Irwin N. Sandler; Yue Ma; Jenn-Yun Tein; Tim S. Ayers; Sharlene Wolchik; Cara Kennedy; Roger Millsap

2010-01-01

113

Long-Term Effects of the Family Bereavement Program on Multiple Indicators of Grief in Parentally Bereaved Children and Adolescents  

ERIC Educational Resources Information Center

Objectives: This article reports on results from a randomized experimental trial of the effects of the Family Bereavement Program (FBP) on multiple measures of grief experienced by parentally bereaved children and adolescents over a 6-year period. Method: Participants were 244 youths (ages 8-16, mean age = 11.4 years) from 156 families that had…

Sandler, Irwin N.; Ma, Yue; Tein, Jenn-Yun; Ayers, Tim S.; Wolchik, Sharlene; Kennedy, Cara; Millsap, Roger

2010-01-01

114

Multiple KRAS Mutations in Pancreatic Adenocarcinoma: Molecular Features of Neoplastic Clones Indicate the Selection of Divergent Populations of Tumor Cells.  

PubMed

KRAS is one of the most common genes mutated in pancreatic adenocarcinoma. Multiple KRAS mutations may be detected within the same pancreatic adenocarcinoma, but it is usually unclear whether the different mutations represent biologically irrelevant molecular events or whether they indicate the coexistence of distinct sizable neoplastic clones within a given tumor. We identified a case of pancreatic adenocarcinoma with 5 different mutations in the KRAS gene and have been able to characterize the allelic distribution of the KRAS mutations and the size of the neoplastic clones using allele-specific locked nucleic acid polymerase chain reaction and next-generation sequencing (454 GS-Junior). The results indicate that the tumor is composed of 5 distinct cell populations: one is KRAS G12V mutated (~38% of neoplastic cells), the second is KRAS G12V in one allele and KRAS G12D in the other (~32%), the third is KRAS G12V in one allele and KRAS G12R in the other (~24%), and the fourth is KRAS G12V in one allele and KRAS G12C in the other (~6%). The fifth clone, representing a minority of neoplastic cells, has a KRAS Q61H mutation in addition to one of the above alterations. Microsatellite analysis identified mutation of the NR21 marker out of the 13 tested, indicating that the tumor has a defect in maintaining DNA integrity different from loss of conventional DNA mismatch repair. These results are consistent with the successive selection of divergent populations of tumor cells and underscore the relevance of nucleotide instability in pancreatic adenocarcinoma. PMID:23426962

Visani, Michela; de Biase, Dario; Baccarini, Paola; Fabbri, Carlo; Polifemo, Anna Maria; Zanini, Nicola; Pession, Annalisa; Tallini, Giovanni

2013-02-19

115

Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients.  

PubMed

Alzheime?s disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM). In the current study, multiple indices of diffusion tensor imaging (DTI) and brain volumetric measurements were employed to comprehensively investigate the landscape of AD pathology. The sample comprised 58 individuals including cognitively normal subjects (controls), amnestic mild cognitive impairment (MCI) and AD patients. Relative to controls, both MCI and AD subjects showed widespread changes of anisotropic fraction (FA) in the corpus callosum, cingulate and uncinate fasciculus. Mean diffusivity and radial changes were also observed in AD patients in comparison with controls. After controlling for the gray matter atrophy the number of regions of significantly lower FA in AD patients relative to controls was decreased; nonetheless, unique areas of microstructural damage remained, e.g., the corpus callosum and uncinate fasciculus. Despite sample size limitations, the current results suggest that a combination of secondary and primary degeneration occurrs in MCI and AD, although the secondary degeneration appears to have a more critical role during the stages of disease involving dementia. PMID:23300797

Alves, Gilberto Sousa; O'Dwyer, Laurence; Jurcoane, Alina; Oertel-Knöchel, Viola; Knöchel, Christian; Prvulovic, David; Sudo, Felipe; Alves, Carlos Eduardo; Valente, Letice; Moreira, Denise; Fu?er, Fabian; Karakaya, Tarik; Pantel, Johannes; Engelhardt, Eliasz; Laks, Jerson

2012-12-31

116

Different Patterns of White Matter Degeneration Using Multiple Diffusion Indices and Volumetric Data in Mild Cognitive Impairment and Alzheimer Patients  

PubMed Central

Alzheime?s disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM). In the current study, multiple indices of diffusion tensor imaging (DTI) and brain volumetric measurements were employed to comprehensively investigate the landscape of AD pathology. The sample comprised 58 individuals including cognitively normal subjects (controls), amnestic mild cognitive impairment (MCI) and AD patients. Relative to controls, both MCI and AD subjects showed widespread changes of anisotropic fraction (FA) in the corpus callosum, cingulate and uncinate fasciculus. Mean diffusivity and radial changes were also observed in AD patients in comparison with controls. After controlling for the gray matter atrophy the number of regions of significantly lower FA in AD patients relative to controls was decreased; nonetheless, unique areas of microstructural damage remained, e.g., the corpus callosum and uncinate fasciculus. Despite sample size limitations, the current results suggest that a combination of secondary and primary degeneration occurrs in MCI and AD, although the secondary degeneration appears to have a more critical role during the stages of disease involving dementia.

Alves, Gilberto Sousa; O'Dwyer, Laurence; Jurcoane, Alina; Oertel-Knochel, Viola; Knochel, Christian; Prvulovic, David; Sudo, Felipe; Alves, Carlos Eduardo; Valente, Letice; Moreira, Denise; Fu?er, Fabian; Karakaya, Tarik; Pantel, Johannes; Engelhardt, Eliasz; Laks, Jerson

2012-01-01

117

Trousseau's syndrome: multiple definitions and multiple mechanisms  

Microsoft Academic Search

any kind of coagulopathy occurring in the setting of any kind of malignancy. These multiple definitions of Trousseau's syn- drome are partly the consequence of mul- tiple pathophysiologic mechanisms that apparently contribute to the hypercoagu- lability associated with cancer. Even the classic syndrome probably represents a spectrum of disorders, ranging from exag- gerated fluid-phased thrombosis depen- dent on prothrombotic agents

Ajit Varki

2007-01-01

118

Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple-indicator dilution technique.  

PubMed

We studied the steady-state hepatic extraction and single-pass hepatic uptake of propranolol in isolated perfused livers from normal rats and compared these values with those of rats with carbon tetrachloride-induced cirrhosis, rats treated with chlorpromazine (an inhibitor of propranolol metabolism) and rats with acute liver injury. The kinetics of propranolol transport in the liver were characterized by means of the multiple-indicator dilution technique, and estimates of cellular influx, efflux and sequestration rate constants were obtained with a computer fit to the model of Goresky. The outflow pattern of propranolol in the hepatic veins was then resolved into throughput material, which had swept past the hepatocytes along with albumin, and returning material, which had entered the cells but returned in the outflow after escaping metabolic sequestration. The steady-state extraction of propranolol was significantly decreased in the three experimental groups compared with that in controls, but the outflow profile differed within each group. In cirrhotic animals, influx was markedly decreased and the sequestration rate constant remained unchanged; most of the propranolol in the outflow consisted of throughput material. In rats treated with chlorpromazine, the sequestration rate constant was decreased, and propranolol in the outflow was mainly returning material. In rats with acute liver injury, both influx and sequestration rate constants were decreased. Indicator dilution curves for nonsequestered tracers showed a decreased transit time for red blood cells and abnormal diffusion of albumin and sucrose into the space of Disse in cirrhotic rats compared with the other groups.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8406355

Gariépy, L; Fenyves, D; Kassissia, I; Villeneuve, J P

1993-10-01

119

The influence of multiple indices of socioeconomic disadvantage across the adult life course on the metabolic syndrome: the Vietnam Experience Study  

Microsoft Academic Search

Few studies have explored the relationship between individual and combined multiple indicators of socioeconomic status across the life course and the metabolic syndrome, or attempted to understand the mechanisms underlying any associations. The present study examined the associations between 4 indicators of socioeconomic status, individually and in combination, and metabolic syndrome risk in a study of male US veterans and

Anna C. Phillips; Douglas Carroll; G. Neil Thomas; Catharine R. Gale; Ian Deary; G. David Batty

2010-01-01

120

The Multiple Tasks Test  

Microsoft Academic Search

Simultaneous challenge of posture and cognition (‘dual tasks’) may predict falls better than tests of isolated components of postural control. We describe a new balance test (the Multiple Tasks Test, MTT) which (1) is based upon simultaneous assessment of multiple (>2) postural components; (2) represents everyday situations; and (3) can be applied by clinicians. Relevant risk factors for falls and

Bastiaan R Bloem; Vibeke V Valkenburg; Mathilde Slabbekoorn; Mirjam D Willemsen

2001-01-01

121

Sexuality in multiple sclerosis  

Microsoft Academic Search

Summary. Sexuality and partnership have an important influence on the quality of life of every person and also on people with chronic disorders such as multiple sclerosis. The findings in literature show high evidence that people with multiple sclerosis experience high levels of sexual dysfunction, most of them with hypoactive sexual behaviour often associated with dissatisfaction in relationship, and also

E. Z. Schmidt; P. Hofmann; G. Niederwieser; H.-P. Kapfhammer; R. M. Bonelli

2005-01-01

122

Combination of Multiple Searches  

Microsoft Academic Search

The TREC-3 project at Virginia Tech focused on methods for combining the evidence from multiple retrieval runs and queries to improve retrieval performance over any single retrieval method or query. The largest improvements result from the combination of retrieval paradigms rather than from the use of multiple similar queries.

Joseph A. Shaw; Edward A. Fox

1994-01-01

123

Applying Multiple Intelligences  

ERIC Educational Resources Information Center

|The ideas of multiple intelligences introduced by Howard Gardner of Harvard University more than 25 years ago have taken form in many ways, both in schools and in other sometimes-surprising settings. The silver anniversary of Gardner's learning theory provides an opportunity to reflect on the ways multiple intelligences theory has taken form and…

Christodoulou, Joanna A.

2009-01-01

124

Zur Genetik multipler Hauttumoren  

Microsoft Academic Search

The hypothesis of an autosomal-dominant mode of inheritance in multiple cutaneous leiomyoma, in multiple glomus tumours and in Blue Rubber-Bleb Nevus Syndrome is statistically examined by means of the “maximumlikelihood” procedure. While the available data of the statistical analysis are yet insufficient for a definite answer because of the relatively small number of cases, there is strong evidence for the

U. Berendes

1972-01-01

125

Orchestrating Multiple Intelligences  

ERIC Educational Resources Information Center

|Education policymakers often go astray when they attempt to integrate multiple intelligences theory into schools, according to the originator of the theory, Howard Gardner, and his colleagues. The greatest potential of a multiple intelligences approach to education grows from the concept of a profile of intelligences. Each learner's intelligence…

Moran, Seana; Kornhaber, Mindy; Gardner, Howard

2006-01-01

126

Multiple Endocrine Neoplasia  

Microsoft Academic Search

\\u000a Several genetic syndromes are associated with multiple endocrine tumors. In this chapter, we focus on Multiple Endocrine Neoplasia\\u000a (MEN) types 2 and 1. Von Hippel Lindau and Neurofibromatosis will be discussed in other sections.

Yariv J. Houvras; Gilbert H. Daniels

127

Angiogenesis in multiple myeloma  

Microsoft Academic Search

Angiogenesis is the process of new blood vessel formation, and normally occurs during embryonal growth, wound healing, and the menstrual cycle. It is essential for the proliferation and metastases of most malignant neoplasms. There is now growing evidence that angiogenesis is increased and is likely important in multiple myeloma. Recent evidence suggests that angiogenesis is greater in multiple myeloma compared

S. Vincent Rajkumar; Robert A Kyle

2001-01-01

128

Prediction in Multiple Regression.  

ERIC Educational Resources Information Center

Presents the concept of prediction via multiple regression (MR) and discusses the assumptions underlying multiple regression analyses. Also discusses shrinkage, cross-validation, and double cross-validation of prediction equations and describes how to calculate confidence intervals around individual predictions. (SLD)

Osborne, Jason W.

2000-01-01

129

Multiple cystic pulmonary hamartomas.  

PubMed Central

A patient with multiple cystic hamartomas presented with a pneumothorax and later developed a cystic myxomatous vaginal polyp. This and three of the cysts were resected. She remains well 13 years later. Multiple cystic hamartomas are uncommon and may be misdiagnosed as pulmonary metastases. Images

Mushtaq, M; Ward, S P; Hutchison, J T; Mann, J S

1992-01-01

130

Multiple cystic pulmonary hamartomas.  

PubMed

A patient with multiple cystic hamartomas presented with a pneumothorax and later developed a cystic myxomatous vaginal polyp. This and three of the cysts were resected. She remains well 13 years later. Multiple cystic hamartomas are uncommon and may be misdiagnosed as pulmonary metastases. PMID:1494774

Mushtaq, M; Ward, S P; Hutchison, J T; Mann, J S

1992-12-01

131

Multiple density layered insulator  

DOEpatents

A multiple density layered insulator for use with a laser is disclosed which provides at least two different insulation materials for a laser discharge tube, where the two insulation materials have different thermoconductivities. The multiple layer insulation materials provide for improved thermoconductivity capability for improved laser operation. 4 figs.

Alger, T.W.

1994-09-06

132

Multiple Linear Regression  

NSDL National Science Digital Library

This site, created by Michelle Lacey of Yale University, gives an explanation, a definition and an example of multiple linear regression. Topics include: confidence intervals, tests of significance, and squared multiple correlation. While brief, this is still a valuable site for anyone interested in statistics.

Lacey, Michelle

2009-11-30

133

Reconstruction of advance head and neck cancer patients after tumor ablation with simultaneous multiple free flaps: indications and prognosis.  

PubMed

Simultaneous multiple free flaps have become a useful option in head and neck reconstructions. We performed a 10-year retrospective study between 2001 and 2010. There were 58 men and 1 woman. The overall mortality rate was 51.7%. The longest surviving patient is 9 years and 4 months, whereas the shortest surviving patient was 72 days. The mean survival period was 47.1 (6.8) months. Age (P = 0.755) and tumor size (P = 0.115) did not play a major role, but surgical margin, lymph node, and tumor recurrence were significant in patient survival with a P value of 0.026, 0.01, and 0.026, respectively. If wide excision with a margin that can be free of tumor can be performed, lymph nodes are not involved, and this is a primary tumor, then time and effort should be spent in a successful simultaneous multiple free flap reconstruction. PMID:23154330

Chien, Sou-Hsin; Hsu, Honda; Huang, Chieh-Chi; Lee, Cheng-Yung; Chiu, Chih-Hung Mark; Lin, Chih-Ming

2012-12-01

134

Current multiplication by using multiple thyristors.  

PubMed

This paper presents a circuit topology to obtain current multiplication by using multiple thyristors. To gain insight into this technique, an equivalent circuit model is introduced. Proper operation of the topology was demonstrated by experiments on a small-scale setup including three thyristors. One thyristor is triggered by a trigger circuit; the other two are autotriggered and require no external trigger circuit. The three thyristors could be synchronized automatically in sequence. During the closing process, the discharging of the energy storage capacitors via the thyristors is prevented. The discharging starts when all thyristors are closed, and the currents through each thyristor are simultaneous and identical. The output current is exactly three times the switching current. PMID:18681728

Liu, Z; Pemen, A J M; Van Heesch, E J M; Winands, G J J

2008-07-01

135

Fig trees at the northern limit of their range: the distributions of cryptic pollinators indicate multiple glacial refugia.  

PubMed

Climatic oscillations during the last few million years had well-documented effects on the distributions and genomes of temperate plants and animals, but much less is known of their impacts on tropical and subtropical species. In contrast to Europe and North America, ice-sheets did not cover most of China during glacial periods, and the effects of glacial cycles were less dramatic. Fig trees are a predominantly tropical group pollinated by host-specific fig wasps. We employed partial mitochondrial COI (918?bp) and nuclear ITS2 (462?bp) gene sequences to investigate the genetic structure and demographic histories of the wasps that pollinate the subtropical Ficus pumila var. pumila in Southeastern China. Deep genetic divergence in both mitochondrial (7.2-11.6%) and nuclear genes (1.6-2.9%) indicates that three pollinator species are present and that they diverged about 4.72 and 6.00?Myr bp. This predates the Quaternary ice ages, but corresponds with the formation of the Taiwan Strait and uplifting of the Wuyi-Xianxia Mountains. The three pollinators have largely allopatric distribution patterns in China and display different postglacial demographic histories. Wiebesia spp. 1 and 2 occupy, respectively, the northern and southern regions of the mainland host range. Their populations both underwent significant postglacial spatial expansions, but at different times and at different rates. Wiebesia sp. 3 is largely restricted to northern islands and shows less evidence of recent population expansion. Their mainly allopatric distributions and different demographic histories are consistent with host plant postglacial expansion from three distinct refugia and suggest one mechanism whereby fig trees gain multiple pollinators. PMID:22335780

Chen, Yan; Compton, Stephen G; Liu, Min; Chen, Xiao-Yong

2012-02-15

136

6.NS Adding Multiples  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: Nina was finding multiples of 6. She said, 18 and 42 are both multiples of 6, and when I add them, I also get a multiple of 6: 18+42 = 60. Explain to N...

137

Multiple Myeloma and Diabetes  

PubMed Central

Multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10% of all hematologic cancers. It is characterized by accumulation of clonal plasma cells, predominantly in the bone marrow. The prevalence of type 2 diabetes is increasing; therefore, it is expected that there will be an increase in the diagnosis of multiple myeloma with concomitant diabetes mellitus. The treatment of multiple myeloma and diabetes mellitus is multifaceted. The coexistence of the two conditions in a patient forms a major challenge for physicians.

Issa, Zeinab A.; Zantout, Mira S.; Azar, Sami T.

2011-01-01

138

Multiple intracranial enterogenous cysts.  

PubMed Central

The case of a 40-year-old woman with increasing ataxia is described. Although the clinical presentation and evoked response studies raised the possibility of multiple sclerosis, further investigation revealed multiple cystic intracranial lesions. Surgical excision of one of the lesions relieved the patient's symptoms. Histological examination revealed that this was an enterogenous cyst. Although single cysts of this type have rarely been reported occurring in the posterior cranial fossa, the occurrence of multiple lesions, some in the supratentorial compartment, appears to be unique. Images

Walls, T J; Purohit, D P; Aji, W S; Schofield, I S; Barwick, D D

1986-01-01

139

Multiple food allergy.  

PubMed

This paper is devoted to a study of multiple food allergy, here defined as sensitivity to three or more foods. The purpose of the study is to report findings obtained from a study of 250 private patients and to show what type of persons develop this condition, how it affects them, and what their common allergens are. It was found that multiple food allergy occurs in both sexes and at all ages but is more common in boys than in girls and more common in women then in men. The clinical manifestations were much like those caused by the more familiar inhalant allergy but with a much more widespread constitutional disturbance. The great majority of patients (86%) also reacted to such air-borne allergens as molds, pollens, house dust, and animal epithelials. This indicates that food allergy and inhalant allergy are fundamentally the same phenomenon. The common food allergens were such everyday foods as milk, chocolate, corn, egg, tomato, peanut, and citrus fruits. PMID:1173207

Speer, F

1975-02-01

140

[Immunosuppressive therapy in multiple sclerosis].  

PubMed

Results of the examination of more than 51 patients with multiple sclerosis and 20 patients of the control group are presented in this article. It is shown that therapy with immunosuppressive medicines (metilprednisolon, dexametason and synakten-depo) is effective as treatment of patients with multiple sclerosis at the stage of exacerbation, making positive effect on the dynamics of the neurological symptoms and immunal indices. The best results were observed among the patients of II and III level of gravity with mainly remitting type of multiple sclerosis. In the comparative aspect pulse-therapy with metilprednisolon was the most effective. PMID:14723143

Vinychuk, S M; Mialovyts'ka, O A; Koliendo, O O

141

Basic Multiple Regression  

NSDL National Science Digital Library

This page will perform basic multiple regression analysis for the case where there are several independent predictor variables, X1, X2, etc., and one dependent or criterion variable, Y. Requires import of data from a spreadsheet.

Lowry, Richard, 1940-

2008-06-25

142

Multiple Thermocouple Testing Device.  

National Technical Information Service (NTIS)

This invention relates generally to a thermocouple testing device, and, more particularly, to an automated multiple thermocouple testing device that checks for short and open circuits. This device can be used to test thermocouple circuits in gas turbine e...

J. R. Hildebrand

1982-01-01

143

Multiple duty battery  

SciTech Connect

A laminar battery capable of providing multiple currents and capacities at different voltages is described in which electrical access is provided to intermediate cells in the battery by conductive metal terminal layers incorporated in the structure of the battery.

Cohen, F.S.; Hyland, A.L.

1980-05-20

144

Photovoltaics: Separating Multiple Excitons  

SciTech Connect

Scientists have demonstrated an efficient process for generating multiple excitons in adjacent silicon nanocrystals from a single high-energy photon. Their findings could prove useful for a wide range of photovoltaic applications.

Nozik, A. J.

2012-05-01

145

Multiplication Series: Number Arrays  

NSDL National Science Digital Library

This one-page article describes and illustrates how arrays can be used to represent many number concepts, including building multiplication facts, commutativity, parity (odd/even), and exploring factors, prime numbers, and square numbers.

2002-10-01

146

Cannabinoids and Multiple Sclerosis  

Microsoft Academic Search

This review discusses clinical and preclinical evidence that supports the use of cannabinoid receptor agonists for the management\\u000a of multiple sclerosis. In addition, it considers preclinical findings that suggest that as well as ameliorating signs and\\u000a symptoms of multiple sclerosis, cannabinoid CB1 and\\/or CB2 receptor activation may suppress some of the pathological changes that give rise to these signs and

Roger G. Pertwee

2007-01-01

147

Multiple sclerosis in pregnancy.  

PubMed

Multiple sclerosis is the most common chronic neurologic disability in young adults in their childbearing ages of 20 to 45. The disease affects more women than men, which prompts discussion of pregnancy-related issues in a woman with multiple sclerosis. Preconceptual counseling to discuss the safety of medications in pregnancy, the antepartum period along with what the patient can expect during birth, and the postpartum period will be discussed. PMID:23899802

Baird, Suzanne McMurtry; Dalton, Jennifer

148

Laquinimod in multiple sclerosis  

Microsoft Academic Search

Laquinimod is a novel, orally administered immune-modulatory molecule in advanced phase clinical trials in relapsing–remitting multiple sclerosis. Experimental evidence to date, derived mostly from animal models of multiple sclerosis, suggests that laquinimod may mediate its effects via modulating pro-inflammatory immune responses and interfering with cell trafficking, as well as potentially acting directly in the central nervous system to limit demyelination

Paul S. Giacomini; Amit Bar-Or

149

Multiplication as Combinations  

NSDL National Science Digital Library

In this lesson plan students explore how to use multiplication to find the number of combinations possible in various situations. They follow the Cyberchase kids through two short videos as they explore creating a matrix and a tree diagram to solve the number of combinations; looking for patterns across data and leading to the conclusion that the same solutions could have been found through multiplication (counting principle). The lesson plan includes two student worksheets, two assessment options, and an answer key (rtf).

Education, Wnet O.

2006-01-01

150

Hyperhomocysteinaemia and multiple aneurysms.  

PubMed Central

Homozygous homocystinuria, the most common genetic disorder of transulphuration, is associated with elevated plasma concentrations of homocystine, homocysteine, multiple clinical abnormalities and life-threatening thromboembolism. Several instances of vascular aneurysms have also been documented. More recently, an association between premature occlusive vascular disease and the heterozygous state has been proposed. We now report an unusual case in whom multiple aneurysms were associated with heterozygous homocystinuria. Images Figure 1 Figure 2

Colwell, N.; Clarke, R.; Robinson, K.; Keane, F.; O'Briain, S.; Graham, I.

1991-01-01

151

Pyrochemical multiplicity counter development  

SciTech Connect

Impure plutonium-bearing materials from pyrochemical processes often display both significant self-multiplication and variable ({alpha},n) reaction rates. Standard neutron coincidence counting techniques usually fail to accurately measure these materials. Neutron multiplicity counters measure the third moment of the neutron multiplicity distribution and thus make it possible to deduce the fertile plutonium mass of a sample even when both the self-multiplication and the ({alpha},n) reaction rate are unknown. A multiplicity counter suitable for measuring pyrochemical materials has been designed and built. This paper describes the results of characterization studies for the new counter. The counter consists of 126 helium-3 tubes arranged in 4 concentric rings in a polyethylene moderator; the average spacing between the tubes is 1.59 cm. The end plugs for the counter are made of graphite, and the 24.1- by 37.5-cm sample cavity is cadmium lined. The counter consists of two distinct halves from which the neutron counts are summed. The counter is capable of operation in either a freestanding mode with the two halves coupled together by an external cabinet or in a glove-box mode with the two halves placed around a glovebox well and then mated. For a {sup 252}Cf source centered in the sample cavity, the measured efficiency of the new multiplicity counter is 57.7% and its die-away time is 47.2{mu}s. 8 refs., 9 figs.

Langner, D.G.; Dytlewski, N.; Krick, M.S.

1991-01-01

152

Multiple punishment schedule1  

PubMed Central

Concurrent schedules of punishment and fixed-ratio reinforcement were studied in six white Carneaux pigeons. Two stimuli were alternated on the translucent key which served as the response mechanism. The pigeons were exposed to continuous punishment in one stimulus and first response punishment in the other. It was found that continuous punishment suppressed the fixed-ratio performance more than did punishment of the first response. Typically, a ratio run of responses was completed in spite of the onset of continuous punishment. Responding was then reduced for the remainder of the continuous punishment stimulus, except for those times when responding was initiated near the end of the stimulus. The results indicate that a multiple schedule can be used to compare different schedules of punishment in the same organism.

DeArmond, Diane

1966-01-01

153

Trousseau's syndrome: multiple definitions and multiple mechanisms  

PubMed Central

In 1865, Armand Trousseau noted that unexpected or migratory thrombophlebitis could be a forewarning of an occult visceral malignancy. An analysis by Sack and colleagues in 1977 extended the term Trousseau's syndrome to include chronic disseminated intravascular coagulopathy associated with microangiopathy, verrucous endocarditis, and arterial emboli in patients with cancer, often occurring with mucin-positive carcinomas. In recent times the term has been ascribed to various clinical situations, ranging all the way from these classic descriptions to any kind of coagulopathy occurring in the setting of any kind of malignancy. These multiple definitions of Trousseau's syndrome are partly the consequence of multiple pathophysiologic mechanisms that apparently contribute to the hypercoagulability associated with cancer. Even the classic syndrome probably represents a spectrum of disorders, ranging from exaggerated fluid-phased thrombosis dependent on prothrombotic agents such as tissue factor to a platelet- and endotheliumum-based selectin-dependent microangiopathy associated with mucin-producing carcinomas, along with thrombin and fibrin production. Also considered here are recent hypotheses about genetic pathways within tumor cells that might trigger these thrombotic phenomena, and the reasons why therapy with heparins of various kinds remain the preferred treatment, probably because of their salutary actions on several of the proposed pathologic mechanisms.

2007-01-01

154

Optical-biophysical relationships and validation of MODIS vegetation indices with multiple fine spatial resolution data in semiarid rangelands  

NASA Astrophysics Data System (ADS)

The vegetation index products from the Moderate Resolution Imaging Spectroradiometer (MODIS) are designed to provide consistent, spatial and temporal comparisons of global vegetation conditions. The objective of this dissertation was to validate the robustness and global implementation of two MODIS VI algorithms, including the normalized difference vegetation index (NDVI) and "enhanced" vegetation index (EVI). Their performances have been evaluated in: (1) the normalization of canopy background (brightness) variations and the extraction of biophysical parameters across different canopy structures; (2) the characterization of seasonal vegetation profiles (phenological, intra-annual); and (3) spatial and temporal discrimination of vegetation differences (inter-annual). The validation was accomplished through multiple means, including canopy radiative transfer models which were utilized to extract pure vegetation spectra and "true" VI value free of background contamination for varying canopy structures and vegetation amount. The experimental field- and airborne-based radiometry and satellite imagery at multiple spatial resolutions were also coupled and scaled-up for comparison with coarse spatial resolution MODIS VI products to quantify characteristics of semiarid rangeland vegetation. The results showed that NDVI was advantageous in yielding biophysical relationships applicable across varying canopy types, but required knowledge of soils for biophysical estimations. The EVI provided biophysical relationships sensitive to canopy structure, thus requiring knowledge of canopy type for biophysical assessments. The MODIS VI products were successfully validated, radiometrically, by coupling field and the MODLAND Quick Airborne Looks (MQUALS) observations to high spatial resolution imagery (AVIRIS and ETM+), and appeared robust across the two parallel sites for depicting their ecological equivalents. MODIS multitemporal VI profiles were able to depict phenological activity, length of the growing season, peak and onset of greenness, and leaf turnover. Among the sensors tested, spatial resolution was found to be most important for discriminating the major land cover subtypes within the two parallel semiarid rangelands, and spectral resolution had major effects on capturing seasonal contrast due to atmosphere influences. The validation strategy utilized in this study to successively aggregate the integrity-inherent multiple fine spatial resolution data to the coarse MODIS pixel sizes appeared to perform well, thus showing potentials in the validation of other satellite products.

Gao, Xiang

155

Multiple Intelligences and Business Diversity.  

ERIC Educational Resources Information Center

|Results from 97 business students with substantial work histories indicate that the Multiple Intelligence Preference Inventory gives a valid and reliable indication of their preferred intelligences. Awareness of these results is associated with assessments of self and others as knowledge sources. This information can help in recognizing,…

Martin, Joyce

2003-01-01

156

Online multiple instance regression  

NASA Astrophysics Data System (ADS)

The multiple instance regression problem has become a hot research topic recently. There are several approaches to the multiple instance regression problem, such as Salience, Citation KNN, and MI-ClusterRegress. All of these solutions work in batch mode during the training step. However, in practice, examples usually arrive in sequence. Therefore, the training step cannot be accomplished once. In this paper, an online multiple instance regression method “OnlineMIR" is proposed. OnlineMIR can not only predict the label of a new bag, but also update the current regression model with the latest arrived bag. The experimental results show that OnlineMIR achieves good performances on both synthetic and real data sets.

Wang, Zhi-Gang; Zhao, Zeng-Shun; Zhang, Chang-Shui

2013-09-01

157

Laquinimod in multiple sclerosis.  

PubMed

Laquinimod is a novel, orally administered immune-modulatory molecule in advanced phase clinical trials in relapsing-remitting multiple sclerosis. Experimental evidence to date, derived mostly from animal models of multiple sclerosis, suggests that laquinimod may mediate its effects via modulating pro-inflammatory immune responses and interfering with cell trafficking, as well as potentially acting directly in the central nervous system to limit demyelination and axonal injury. The clinical trial results to date have established efficacy on imaging markers of disease activity and have shown a favorable safety and tolerability profile. If phase III studies confirm clinical efficacy and safety, laquinimod would represent a welcome new option in the treatment of multiple sclerosis. PMID:21450529

Giacomini, Paul S; Bar-Or, Amit

2011-03-04

158

Factor-multiple Chains  

NSDL National Science Digital Library

This problem offers opportunities for students to reinforce their understanding of factors and multiples and provides them the chance to justify their solutions. The goal is for the students to create number chains of four whole numbers that can range from 2 to 100 and each consecutive number is a multiple of the previous number. The Teachers' Notes page offers suggestions for implementation, key discussion questions, ideas for extension and support, and a link to a spreadsheet for students to experiment with placing numbers in specific boxes in the chain.

2007-04-01

159

FCam for multiple cameras  

NASA Astrophysics Data System (ADS)

The Frankencamera (FCam) architecture and API enables precise control over the camera in computational photography applications. We present an extension to FCam API for systems equipped with multiple cameras. The proposed extension allows for an enumeration of cameras and their corresponding properties, such as position or orientation. In addition, we explicitly support camera synchronization, either through hardware mechanisms or software primitives. If hardware synchronization is available, cameras can be grouped together under a concept of a multi-sensor. Otherwise, multiple camera streams are scheduled asynchronously and synchronized using our software control primitives.

Troccoli, Alejandro; Pajak, Dawid; Pulli, Kari

2012-02-01

160

Multiple cemental tears.  

PubMed

A cemental tear is a pathologic condition in which a complete or incomplete separation of the cementum occurs along the root surface and is usually accompanied by a deep periodontal pocket. Past articles report that the incidence of cemental tears has usually been limited to 1 tooth per individual. We encountered a clinical case with cemental tears involving 14 teeth in 1 individual. Multiple cemental tears in 1 individual have not been previously described in the dental literature. We present the clinical and pathologic features of this rare case and suggest that the probable cause of multiple cemental tears is structural weakness of the cementum. PMID:22862978

Watanabe, Chie; Watanabe, Yoshihisa; Miyauchi, Mutsumi; Fujita, Minoru; Watanabe, Yoshiyuki

2012-03-05

161

Multiple Rankine topping cycles  

SciTech Connect

The efficiency of a Rankine cycle is primarily determined by the temperatures of heat addition and rejection. However, no working fluid has been identified which will operate in a Rankine cycle over an extremely wide temperature range. Multiple Rankine topping cycles offer a technique for achieving high thermal efficiencies in power plants by allowing the use of several working fluids. This paper gives a history of Rankine topping cycles, presents an analysis for the calculation of the overall efficiency of a three-module multiple Rankine cycle, and presents results from a case study for a sodium-mercury-water cycle.

McWhirter, J.D. [Argonne National Lab., Idaho Falls, ID (United States). Engineering Div.]|[Idaho State Univ., Pocatello, ID (United States). Coll. of Engineering

1995-07-01

162

Multiple Endocrine Neoplasia Syndromes  

PubMed Central

The multiple endocrine neoplasia (MEN) syndromes consist of three distinct disease entities. They have in common adenomatous, carcinomatous or hyperplastic involvement of a variety of endocrine glands, and an autosomal dominant inheritance. MEN I includes hyperparathyroidism, islet cell and pituitary tumors. The components of MEN IIa are hyperparathyroidism, medullary thyroid carcinoma and pheochromocytoma. MEN IIb includes multiple neuromas, medullary thyroid carcinoma and pheochromocytoma. Effective tests are available for the early detection of components of the syndromes in potentially affected patients. Screening can lead to therapeutic intervention before clinical sequelae ensue.

Pont, Allan

1980-01-01

163

PROBLEMS OF MULTIPLE TRANSFUSIONS  

PubMed Central

The use of blood infusion in large amounts is increasing sharply. Increased knowledge of blood group antigens has alerted physicians to the possible hazards of hemolytic reactions to subgroups that must be eliminated by proper cross-matching techniques. Multiple transfusions of preserved blood often defeat their purpose in control of bleeding, for thrombocytopenia is enhanced. Careful selection of blood or preparations of plasma concentrates offer increased protection to the recipient. Plastic bag equipment increases the yield of viable platelets and keeps blood in usable condition for longer periods of storage. The use of multiple transfusions has complicated the selection of preserved blood to control pigment metabolism.

Gardner, Frank H.

1958-01-01

164

Indices of cognitive dysfunction in relapsing-remitting multiple sclerosis: intra-individual variability, processing speed, and attention network efficiency.  

PubMed

Impairments in attention and information processing speed are common in multiple sclerosis (MS) and may contribute to impairments of other cognitive abilities. This study examined attentional efficiency, information processing speed and intra-individual variability in response speed using the Attention Network Test-Interactions (ANT-I) in mildy-affected patients with MS. Thirty-one patients with relapsing-remitting MS and 30 age, sex, and education-matched controls completed the ANT-I, as well as the Paced Auditory Serial Attention Test (PASAT), as a standard clinical measure of information processing efficiency. As expected, patients with MS were slower in reaction time performance on the ANT-I and had poorer performance on the PASAT compared to controls. Patients with MS also demonstrated poorer efficiency in their executive control of attention on the ANT-I, suggesting difficulties with top-down allocation of attention. In addition, the MS group demonstrated greater intra-individual variability in the responses to the ANT-I even when their slower overall response time and other factors such as practice were accounted for. Intra-individual variability was found to best predict group membership compared to PASAT scores and other ANT-I scores. These results suggest that intra-individual variability may provide sensitive, unique and important information regarding cognitive functioning in early MS. PMID:23425598

Wojtowicz, Magdalena; Omisade, Antonina; Fisk, John D

2013-02-21

165

Multiple sclerosis: Mechanisms of disability accumulation in multiple sclerosis.  

PubMed

Natural history studies have identified numerous features of disability progression in patients with multiple sclerosis (MS), and have provided valuable insight into the underlying pathology of the disease that could assist the development of new treatment strategies. A new study indicates that disability progression occurs in two stages in patients with MS. PMID:21131915

Conway, Devon S; Cohen, Jeffrey A

2010-12-01

166

Cannabinoids and multiple sclerosis  

Microsoft Academic Search

There is a growing amount of evidence to suggest that cannabis and individual cannabinoids may be effective in suppressing certain symptoms of multiple sclerosis and spinal cord injury, including spasticity and pain. Anecdotal evidence is to be found in newspaper reports and also in responses to questionnaires. Clinical evidence comes from trials, albeit with rather small numbers of patients. These

Roger G Pertwee

2002-01-01

167

Multiple listerial liver abscesses  

Microsoft Academic Search

Hepatic involvement in listeriosis is uncommon in adults. Cases previously reported include three presenting as acute hepatitis and three of listerial liver abscesses found at necropsy. We report a case of multiple listerial liver abscesses. We believe this to be the first time this diagnosis has been made in a living patient.

D Jenkins; J E Richards; Y Rees; A C Wicks

1987-01-01

168

Comments on Multiple Representation  

Microsoft Academic Search

Finally, we note Reisner's comments on the impact of the cooperation initiatives on potential multiple representation scenarios. Reisner observed that credit likely will be limited to the first person who cooperates, and that a cooperator's assistance could well implicate other individuals. Accordingly, Reisner noted that when considering whether joint representation is appropriate in a given case, counsel should consider each

Davis Polk; Wardwell LLP; Michael P. Carroll; Neal A. Potischman; Linda Chatman Thomsen; Daniel J. O'Neill

169

Scattering Division Multiple Access  

Microsoft Academic Search

The paper presents a new way of multiplexing digital communication over cable networks. The system is innovative in three ways. Firstly, the way the multiple access scheme is achieved. Actually, most of current cable multiplexing systems use TDMA. Other well known techniques -especially in wireless domain -use FDMA, CDMA or SDMA. The proposed system uses the scattering properties of the

Luc Haumonte; L. Deneire

2007-01-01

170

Multiple Intelligences: A Collection.  

ERIC Educational Resources Information Center

|As a concise resource for Howard Gardner's theory of multiple intelligences and its implications for schooling around the world, this collection is designed for educators, parents, and others interested in education. The first section discusses Gardner and his background, and the second section expounds his theory. The third section explores the…

Fogarty, Robin, Ed.; Bellanca, James, Ed.

171

Predicting Multiple Unit Franchising  

Microsoft Academic Search

This paper examines the current status of multiple unit franchising in Australia. A review of previous research in the United States highlights some characteristics that may be unique to the Australian setting such as the age and size of franchise systems, the “hands on” involvement and experience of existing franchisees, monitoring cost effects, the use of franchisor performance evaluation and

Scott Weaven; Lorelle Frazer

2003-01-01

172

Multiple Instruction Stream Processor  

Microsoft Academic Search

Microprocessor design is undergoing a major paradigm shift towards multi-core designs, in anticipation that fu- ture performance gains will come from exploiting thread- level parallelism in the software. To support this trend, we present a novel processor architecture called the Multiple Instruction Stream Processing (MISP) architecture. MISP introduces the sequencer as a new category of architectural resource, and defines a

Richard A. Hankins; Gautham N. Chinya; Jamison D. Collins; Perry H. Wang; Ryan Rakvic; Hong Wang; John Paul Shen

2006-01-01

173

Diagnosis of Multiple Sclerosis.  

National Technical Information Service (NTIS)

This thesis describes recently developed research methods for the diagnosis of multiple sclerosis. In Chapter X the use of the CT-scan in the detection of hemispheral or cerebellar lesions is discussed. In chapter XIII the results of the application of al...

E. A. C. M. Sanders

1982-01-01

174

Multiple Slit Diffraction Model  

NSDL National Science Digital Library

The EJS Multiple Slit Diffraction model allows the user to simulate Fraunhofer diffraction through single or multiple slits. The user can modify the number of slits, the slit width, the slit separation and the wavelength of the incident light. The scale of the diffraction pattern can also be changed and a plot of the light intensity can be toggled on and off with a checkbox. A basic theoretical introduction to diffraction is included. The Multiple Slit Diffraction Model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_ntnu_optics_MultipleSlitDiffraction.jar file will run the program if Java is installed. Ejs is a part of the Open Source Physics Project and is designed to make it easier to access, modify, and generate computer models. Additional Open Source Physics programs for quantum mechanics are available. They can be found by searching ComPADRE for Open Source Physics, OSP, or EJS.

Hwang, Fu-Kwun

2008-11-22

175

Multiple Myeloma: Current Perspectives  

Microsoft Academic Search

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells characterized by complex genetic aberrations and heterogeneous outcomes. Over the past 25 years, cytogenetic analysis has played a key role in the diagnosis and management of MM. Nearly all patients show chromosome aberrations by conventional karyotyping or fluorescence in situ hybridization (FISH), providing the basis for genetically defined subgroups

Marilyn L. Slovak

176

Multiple beam klystron operation  

Microsoft Academic Search

Summary form only given. Results for the operation of a 1.3 GHz, 10 MW multiple beam klystron which is being developed for the TESLA linear accelerator facility are reported. The long operational lifetime required for this application has resulted in the use of off-axis cathodes in the design. The placement of the individual beam axes on a large bolt circle

A. Balkcum; E. Wright; H. Bohlen; M. Cattelino; L. Cox; M. Cusick; K. Eppley; S. Forrest; F. Friedlander; A. Staprans; L. Zitelli

2004-01-01

177

Multiple gap photovoltaic device  

DOEpatents

A multiple gap photovoltaic device having a transparent electrical contact adjacent a first cell which in turn is adjacent a second cell on an opaque electrical contact, includes utilizing an amorphous semiconductor as the first cell and a crystalline semiconductor as the second cell.

Dalal, Vikram L. (Newark, DE)

1981-01-01

178

Multiple primary melanomas  

Microsoft Academic Search

Background: Patients with clinically diagnosed dysplastic nevi or a family history of melanoma with or without histologically diagnosed dysplastic nevi seem to be at higher risk for the development of multiple melanomas. Objective: Our purpose was to determine which factors increased the risk for the development of subsequent melanomas. Methods: This was a retrospective study in 56 patients with 157

Jeannet J. Stam-Posthuma; Caroline van Duinen; Eric Scheffer; Jacqueline Vink; Wilma Bergman

2001-01-01

179

‘Nonsecretory’ Multiple Myeloma  

Microsoft Academic Search

A case of multiple myeloma without synthesis of myeloma protein is described. Its outstanding features were:typical skeletal lesions, absence of paraproteinemia and Bence-Jones proteinuria, decreased levels of serum immunoglobulins, and absence of parenchymal lesions and of amyloidosis.Copyright © 1974 S. Karger AG, Basel

F. Indiveri; A. Barabino; M. E. Santolini; B. Santolini

1974-01-01

180

Multiple System Atrophy (MSA)  

MedlinePLUS

... many Parkinson's disease-like symptoms, such as slowness of movement, muscle rigidity and poor balance. Multiple system atrophy is a degenerative disease that develops in adulthood, usually in the 50s or 60s, and affects more men than women. The condition progresses gradually and eventually ...

181

Multiple Choice Test  

NSDL National Science Digital Library

This site presents a guide to developing and deploying effective multiple choice tests. The site also discusses the costs and benefits of this method, as well as the philosophy of this commonly used assessment method. Links to more detailed information are included as well.

Parkes, Jay; Guide, Field-Tested L.

182

Multiple sclerosis: Symptomatic treatment  

Microsoft Academic Search

Reports of new therapeutic agents designed to suppress inflammatory processes in multiple sclerosis have excited much interest but, thus far, have had little influence on symptoms, disability and handicap in patients. The clinical application of recent advances in physical, pharmacological and surgical approaches to management will, at least in the medium-term future, therefore offer significantly greater opportunities for improving the

A. J. Thompson

1996-01-01

183

Multiplication from Other Operations.  

National Technical Information Service (NTIS)

Given the operations of subtraction and reciprocal-taking, the authors show that the operation of multiplication is determined in any field. The amusing difference is that for characteristic 2 it is not given by a formula, whereas for other characteristic...

D. J. Newman S. Kohn

1970-01-01

184

New Error type and Recall Consistency Indices for the Brief Visuospatial Memory Test ?–?Revised: Performance in Healthy Adults and Multiple Sclerosis Patients  

Microsoft Academic Search

The Brief Visuospatial Memory Test ?–?Revised (BVMT-R) is a reliable and well-validated test of visual-spatial memory with six equivalent, alternate forms. While the BVMT-R is commonly used in the evaluation of patients with craniocerebral trauma, schizophrenia, and multiple sclerosis (MS), the range of variables is limited. In this study, we developed new BVMT-R error and recall consistency indices. Inter-rater reliability

Jeffrey J. Gaines; Rebecca A. Gavett; Joshua J. Lynch; Rohit Bakshi; Ralph H. B. Benedict

2008-01-01

185

New approaches to multiple myeloma  

Microsoft Academic Search

Significant advances in the treatment of multiple myeloma have been made over the past several years. This progress is due in large part to the advent of several active targeted therapies that are proving more effective than traditional cytotoxic chemotherapy. Thalidomide, lenalidomide, and bortezomib are all now indicated for treatment of relapsed\\/ refractory disease and are being actively investigated for

Amitabha Mazumder

186

Individual Differences and Multiple Intelligences.  

ERIC Educational Resources Information Center

Recent educational research indicates that learners differ in their preferences for learning mode and strategies. Implications for instruction and assessment are discussed as they relate to the Theory of Multiple Intelligences of H. Gardner (1983). One of the principles of the "Learner Centered Psychological Principles" of the American…

Fasko, Daniel, Jr.

187

Dimensions of Multiple Personality Disorder  

Microsoft Academic Search

Research on multiple personality disorder (MPD) has burgeoned, and large-scale investigations indicate that a typical MPD patient is a woman, a victim of childhood abuse (especially sexual abuse), a person whose symptoms meet criteria for other psychiatric disorders, and a person who would employ many psychological defenses. Treatment approaches have frequently included hypnotherapy, which requires skill and caution.

John B. Murray

1994-01-01

188

Multiple myeloma: evaluation by CT  

SciTech Connect

Although patients who have multiple myeloma usually have straightforward clinical symptoms and corroborative radiographs, in some instances, these patients will present atypically, with symptoms suggesting active disease but radiographs that are normal or nonspecific. The authors reviewed the records of 32 patients who had documented multiple myeloma and had undergone CT examinations, assessing the value of those examinations. Although CT is not indicated in all patients who have multiple myeloma, it is especially useful in patients who have bone pain and normal or nonspecific radiographs. CT provided confirmatory information in all cases in which lesions were seen on radiographs. CT also frequently demonstrated a greater extent of disease than could be appreciated on the radiographs.

Schreiman, J.S.; McLeod, R.A.; Kyle, R.A.; Beabout, J.W.

1985-02-01

189

Multiple harmonic plasma emission  

SciTech Connect

A generalized weak turbulence theory for electromagnetic emission at multiple harmonics of the plasma frequency is developed. In the literature, the electromagnetic emission at the plasma frequency and/or its second harmonic has been intensively studied. However, the emission at harmonics higher than the second harmonic is scarcely discussed. In the present paper, the higher harmonic plasma emission is explained by taking the interactions between the transverse mode and electrostatic nonlinear eigenmodes into consideration. The present analysis incorporates electrostatic nonlinear harmonic Langmuir waves into the fully electromagnetic weak turbulence formalism recently reformulated on the basis of the statistical mechanical Klimontovich approach. The wave kinetic equations for the transverse electromagnetic and Langmuir waves interacting with the harmonic Langmuir waves are derived, on the basis of which the emission of electromagnetic waves near multiple harmonics of the plasma frequency is qualitatively discussed.

Yi, Sumin; Yoon, Peter H.; Ryu, Chang-Mo [Department of Physics, Pohang University of Science and Technology, Pohang (Korea, Republic of); Institute for Physical Science and Technology, University of Maryland, College Park, Maryland 20742 (United States); Department of Physics, Pohang University of Science and Technology, Pohang (Korea, Republic of)

2007-01-15

190

Multiple keratoacanthoma centrifugum marginatum.  

PubMed

Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma characterized by a progressive peripheral growth with concomitant central healing. We report here a case of multiple KCM of the lower legs in a 48-year-old man. The lesions had progressively evolved over 3 years. They were multiple asymptomatic and confluent annular plaques of 5 to 20 cm, having papulo-nodular with hyperkeratotic and crusted borders and cicatricial center. Within the centers were numerous firm and pigmented minipapules of 1 to 2 mm. The typical clinical aspect, together with characteristic histological features confirmed the diagnosis of KCM. Herein we will highlight the clinical and histological features of KCM, as well as the different effective treatments. We will also briefly discuss KCM among the other types of keratoacanthomas. PMID:21062610

Khaled, Aida; Kourda, Monia; Fazaa, Becima; Zermani, Rachida; Kamoun, Mohamed Ridha

2010-10-15

191

Curability of Multiple Myeloma  

PubMed Central

Among 792 patients with multiple myeloma treated from 1987 to 2010 and assessed after 18 months, there were 167 patients with complete remission. For those 60 patients treated between 1987–1998 and with long followup, the latest relapse occurred after 11.8 years, so that 13 patients have remained in sustained complete remission for longer than 12 years (range 12–22 years). These results suggest that 3% of all patients treated during that period may be cured of multiple myeloma. In addition to immunofixation, more sensitive techniques for the detection of residual disease should be applied more consistently in patients with apparent complete remission in order to identify those with potential cure.

Alexanian, Raymond; Delasalle, Kay; Wang, Michael; Thomas, Sheeba; Weber, Donna

2012-01-01

192

History of Multiple Myeloma  

Microsoft Academic Search

\\u000a Multiple Myeloma has been recognized since Ancient Times. The first well-documented case was reported in 1844 by Samuel Solly.\\u000a The most commonly recognized case is that of Thomas Alexander McBean, a highly respectable tradesman from London in 1850.\\u000a Mr. McBean excreted a large amount of protein that was described by Henry Bence Jones in the middle of the 19th century.

Robert A. Kyle; David P. Steensma

193

Multiple sclerosis in Pakistan  

Microsoft Academic Search

We describe retrospective data from the largest series of patients (n \\/142) with multiple sclerosis (MS) from Pakistan. Mean age at onset was 27 years, with a female to male ratio of 1.45:1. The disease onset was polysymptomatic in 75% patients. Motor weakness was the most common onset symptom (70%), followed by sensory symptoms (45%). Optico-spinal type of MS was

M. Wasay; S. Ali; I. A. Khatri; A. Hassan; M. Asif; N. Zakiullah; A. Ahmed; A. Malik; B. Khealani; A. Haq; S. Fredrikson

2007-01-01

194

Multiple Stressors and Disturbances  

Microsoft Academic Search

\\u000a Marine communities are increasingly affected by numerous stressors that act as agents of physical and biological disturbance\\u000a through a combination of natural and human-induced impacts. These include storms, sedimentation, temperature changes, pollution,\\u000a eutrophication, over-harvesting, damage to habitats, arrival of invasive species and climate change. Here I discuss how multiple\\u000a stressors alter assemblages on rocky reefs through direct impacts on organisms

David R. Schiel

195

Multiple Peril Crop Insurance  

Microsoft Academic Search

Multiple Peril Crop Insurance (MPCI) is a broad-based crop insurance program regulated by the U.S. Department of Agriculture and subsidized by the Federal Crop Insurance Corporation(FCIC). Crops eligible for MPCI coverage in Iowa include corn, sobyeans, oats, wheat, seed corn, popcorn, barley, potatoes, sweet corn, canning beans, dry beans, forages, grain sorghum, green peas, tomatoes, and nursery stocks. Not all

William M. Edwards; Donald Hofstrand

2003-01-01

196

Multiple System Atrophy  

Microsoft Academic Search

Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder characterized clinically by various combinations of\\u000a parkinsonian, autonomic, cerebellar, or pyramidal symptoms and signs and pathologically by cell loss, gliosis, and glial cytoplasmic\\u000a inclusions in several brain and spinal cord structures. The term MSA was introduced in 1969, however cases of MSA were previously\\u000a reported under the rubrics of striatonigral degeneration,

Felix Geser; Gregor K. Wenning

197

Pregnancy and Multiple Sclerosis  

Microsoft Academic Search

Numerous autoimmune diseases affect women during their reproductive years, including multiple sclerosis (MS), rheumatoid arthritis,\\u000a systemic lupus erythematosus, myasthenia gravis, and Sjögren’s syndrome (1–3). Most autoimmune diseases become clinically silent or are pushed into so-called “remission” during pregnancy (4). Pregnancy poses a challenge for the immune system because the fetus is essentially an allograft harboring antigens from\\u000a the father. In

Christina Caon

198

Multiple Sclerosis and Uveitis  

Microsoft Academic Search

Optic neuritis has a well-recognised association with multiple sclerosis (MS). Forty-five percent of patients with MS have\\u000a been found to have optic atrophy at post mortem [1]. Although MS predominantly involves the optic nerves [2] and the pathways\\u000a controlling eye movements [3], there also appears to be an association between MS and uveitis.\\u000a \\u000a Retinal periphlebitis was first reported in association

Graeme J. Williams

199

Headache in Multiple Sclerosis  

Microsoft Academic Search

Pain, including headache, is a frequent complaint of individuals with multiple sclerosis (MS). Prevalence of headache in patients\\u000a with MS was reported to be higher than 50%, but it is uncertain if this is different than what is seen in the general population.\\u000a Nonetheless, it is possible that MS and headaches are comorbid. Case reports illustrated that isolated MS lesions

Norman Putzki; Zaza Katsarava

2010-01-01

200

Multiple Myeloma and Plasmacytoma  

Microsoft Academic Search

Multiple myeloma (MM) is a clonal disorder of B-cell lymphocytic lineage characterized by malignant transformation of plasma\\u000a cells. It accounts for approx 10% of all the hematological malignancies and 1% of all cancers in the United States. In the\\u000a year 2000, MM was diagnosed in approx 13,700 people in the United States and accounted for 20% of deaths from hematological

Mohamad Hussein

201

Tremor in multiple sclerosis  

Microsoft Academic Search

Tremor is estimated to occur in about 25 to 60 percent of patients with multiple sclerosis (MS). This symptom, which can be\\u000a severely disabling and embarrassing for patients, is difficult to manage. Isoniazid in high doses, carbamazepine, propranolol\\u000a and gluthetimide have been reported to provide some relief, but published evidence of effectiveness is very limited. Most\\u000a trials were of small

Marcus Koch; Jop Mostert; Dorothea Heersema; Jacques De Keyser

2007-01-01

202

Multiple chemical interactions  

SciTech Connect

One of the most complicated aspects of environmental health risk assessment is the evaluation and estimation of risk from exposures to multiple contaminants. While such multiple exposures are the norm rather than the exception, the nature of the calculational tools and models used to estimate risk have generally precluded any quantitative characterization of such risks. Thus, Calabrese's work is a much needed synthesis of knowledge on multiple chemical interactions. The work opens with a review of the historical basis and theoretical foundations of chemical interactions. The author then provides a conceptual framework for evaluating chemical interactions. Following the arguments of Rothman in the early 1970s, Calabrese identifies four contexts within which the concepts of interaction must be discussed: statistical, biological, public health, and individual decision-making. Calabrese next presents a concise but particulate set of definitions of the statistical and biochemical terminology important in studying chemical interactions. On this foundation, he then presents an expert and detailed discussion of the statistical methods and approaches which may be used to quantitatively analyze interactive effects. This section is replete with formulas from both statistics and calculus, although even then the most complicated are clearly explained. The remaining half of the book then looks at interactive effects of specific compounds and classes of compounds and in inducing specific types of health effects. Although much of the information presented in this text is not new, compilation of this chemical-specific information with the treatise on analytical approaches is a new and much needed addition to literature.

Calabrese, E.J.

1991-01-01

203

MULTIPLE OSCILLATION STABILIZING CONTROL.  

SciTech Connect

This paper presents a strategy that may be used to guide stabilizing control design for multiple oscillations, which are difficult to control using conventional control design procedures. A multiple oscillation phenomena is observed in an example power system. A local bifurcation and an interarea bifurcation develop in an example power system due to multiple bifurcation parameter variations. The dynamic behaviors of the bifurcating system are complex due to the overlapping of the two different bifurcation subsystems and are shown to be difficult to control. The double bifurcations are studied in this paper and in order to stabilize them, three kind of {mu}-synthesis robust controls are designed, (a) {mu}-synthesis power system stabilizer (MPSS); (b) {mu}-synthesis SVC control (MSVC); and (c) a mixed MPSS/MSVC control. Based on the bifurcation subsystem analysis, the measurement signals and locations of the controls are selected. The control performances of three kind of controls are evaluated and compared. The conclusions are given according to the analysis and time simulation results.

YUE,M.; SCHLUETER,R.; AZARM,M.; BARI,R.

2004-07-23

204

Multiple protein structure alignment.  

PubMed Central

A method was developed to compare protein structures and to combine them into a multiple structure consensus. Previous methods of multiple structure comparison have only concatenated pairwise alignments or produced a consensus structure by averaging coordinate sets. The current method is a fusion of the fast structure comparison program SSAP and the multiple sequence alignment program MULTAL. As in MULTAL, structures are progressively combined, producing intermediate consensus structures that are compared directly to each other and all remaining single structures. This leads to a hierarchic "condensation," continually evaluated in the light of the emerging conserved core regions. Following the SSAP approach, all interatomic vectors were retained with well-conserved regions distinguished by coherent vector bundles (the structural equivalent of a conserved sequence position). Each bundle of vectors is summarized by a resultant, whereas vector coherence is captured in an error term, which is the only distinction between conserved and variable positions. Resultant vectors are used directly in the comparison, which is weighted by their error values, giving greater importance to the matching of conserved positions. The resultant vectors and their errors can also be used directly in molecular modeling. Applications of the method were assessed by the quality of the resulting sequence alignments, phylogenetic tree construction, and databank scanning with the consensus. Visual assessment of the structural superpositions and consensus structure for various well-characterized families confirmed that the consensus had identified a reasonable core.

Taylor, W. R.; Flores, T. P.; Orengo, C. A.

1994-01-01

205

Exercise and multiple sclerosis.  

PubMed

The pathophysiology of multiple sclerosis (MS) is characterised by fatigue, motor weakness, spasticity, poor balance, heat sensitivity and mental depression. Also, MS symptoms may lead to physical inactivity associated with the development of secondary diseases. Persons with MS are thus challenged by their disability when attempting to pursue an active lifestyle compatible with health-related fitness. Although exercise prescription is gaining favour as a therapeutic strategy to minimise the loss of functional capacity in chronic diseases, it remains under-utilised as an intervention strategy in the MS population. However, a growing number of studies indicate that exercise in patients with mild-to-moderate MS provides similar fitness and psychological benefits as it does in healthy controls. We reviewed numerous studies describing the responses of selected MS patients to acute and chronic exercise compared with healthy controls. All training studies reported positive outcomes that outweighed potential adverse effects of the exercise intervention. Based on our review, this article highlights the role of exercise prescription in the multidisciplinary approach to MS disease management for improving and maintaining functional capacity. Despite the often unpredictable clinical course of MS, exercise programmes designed to increase cardiorespiratory fitness, muscle strength and mobility provide benefits that enhance lifestyle activity and quality of life while reducing risk of secondary disorders. Recommendations for the evaluation of cardiorespiratory fitness, muscle performance and flexibility are presented as well as basic guidelines for individualised exercise testing and training in MS. Special considerations for exercise, including medical management concerns, programme modifications and supervision, in the MS population are discussed. PMID:15575796

White, Lesley J; Dressendorfer, Rudolph H

2004-01-01

206

Multiple Identity Enactments and Multiple Personality Disorder: A Sociocognitive Perspective  

Microsoft Academic Search

People who enact multiple identities behave as if they possess 2 or more selves, each with its own characteristic moods, memories, and behavioral repertoire. Under different names, this phenomenon occurs in many cultures: in North American culture, it is frequently labeled multiple personality disorder (MPD). This article reviews experimental, cross-cultural, historical, and clinical findings concerning multiplicity and examines the implications

Nicholas P. Spanos

1994-01-01

207

Hypersexuality, fetishism and multiple sclerosis.  

PubMed

Hypersexuality and fetishism appeared in a patient with multiple sclerosis whose MRI scan showed frontal and temporal lesions. The hypersexuality may have been the presenting symptom of the multiple sclerosis. PMID:2012924

Huws, R; Shubsachs, A P; Taylor, P J

1991-02-01

208

Network Multiple Station Discriminant Functions.  

National Technical Information Service (NTIS)

An extension is made of linear discriminant analysis to the case where multiple station observations are available for each event. Multivariate regression is used to estimate the mean vectors and covariance matrix in the multiple station discriminant func...

R. Shumway R. R. Blandford

1972-01-01

209

Teaching LD Children Multiplication Tables.  

ERIC Educational Resources Information Center

|Two procedures significantly improved multiplication skills in six students (nine to 12 years old) with learning disabilities. The procedures were writing out multiplication problems and saying problems aloud while working. (CL)|

Lombardo, Thomas W.; Drabman, Ronald S.

1985-01-01

210

Multiple thymic carcinoids.  

PubMed

We present a very rare case of simultaneous thymic carcinoids with similar size, one of which showed spontaneous regression. A 68-year-old man was admitted to the hospital because of two similar abnormal masses at his anterior mediastinum on chest computed tomography, one of which had decreased from 25 to 16 mm in diameter. A total thymectomy was performed and the pathologic examinations revealed that both tumors were atypical carcinoids. There have been seldom reports of multiple thymic carcinoids, and this case might suggest that total thymectomy is the best way to treat thymic carcinoid because of the possibility of multicentric origins. PMID:21619996

Kawaguchi, Koji; Usami, Noriyasu; Okasaka, Toshiki; Yokoi, Kohei

2011-06-01

211

Multiple oligodendroglioma: case report.  

PubMed

An 18-year-old female patient was hospitalized with headache and disturbance of consciousness. Magnetic resonance imaging (MRI) revealed a tumor in the left parieto-occipital lobe. The tumor was totally removed, and postoperative radiation therapy was administered locally at 50 Gy. Ten months later, she experienced sudden onset of unconsciousness and headache. Computed tomography (CT) and MRI demonstrated multiple mass lesions in the whole brain. Following the systemic chemotherapy, removal of the largest tumor was performed. Histological examination proved all excised tumors to be oligodendroglioma without evidence of malignant change. PMID:10794567

Daneyemez, M; Baysefer, A; Can, C; Timurkaynak, E

2000-03-01

212

Hypothermia in multiple sclerosis.  

PubMed Central

Five patients with clinically definite multiple sclerosis are reported who presented with acute relapses associated with hypothermia. Repeated episodes of hypothermia were seen in four. Thrombocytopenia was associated with the hypothermia in four patients. Further investigation disclosed a tendency to chronic hypothermia and suggested an altered thermoregulatory set point in one patient, when MRI, endocrine, and autonomic studies failed to localise a lesion in the hypothalamus, but subsequent necropsy showed hypothalamic lesions. In such patients a predisposition to altered thermoregulation may occur due to direct involvement of the hypothalamus or from combined lesions affecting hypothalamic outflow to the brainstem and spinal cord. Images

White, K D; Scoones, D J; Newman, P K

1996-01-01

213

The neuropsychiatry of multiple sclerosis  

Microsoft Academic Search

Multiple sclerosis usually starts between the ages of 20 and 40 and is characterised by multiple demyelinating lesions with a predilection for the optic nerves, cerebellum, brain-stem and spinal cord. The disorder presents with diverse neurological signs, which reflect the presence and distribution of plaques. Multiple sclerosis is predominantly a white matter disease. The course of the illness is variable

Kate Jefferies

2006-01-01

214

Modeling Multiple Information Seeking Episodes.  

ERIC Educational Resources Information Center

Discussion of information retrieval and information seeking behavior focuses on a multi-dimensional conceptual model called MISE (multiple information-seeking episodes). Identifies eight different reasons why people engage in multiple information-seeking episodes, characterizes them in terms of traits of Multiple Information Seeking Episode…

Lin, Shin-jeng; Belkin, Nicholas J.

2000-01-01

215

Responsiveness of Great Lakes Wetland Indicators to Human Disturbances at Multiple Spatial Scales: A Multi-Assemblage Assessment  

Microsoft Academic Search

Developing indicators of ecosystem condition is a priority in the Great Lakes, but little is known about appropriate spatial scales to characterize disturbance or response for most indicators. We surveyed birds, fish, amphibians, aquatic macroinvertebrates, wetland vegetation, and diatoms at 276 coastal wetland locations throughout the U.S. Great Lakes coastal region during 2002–2004. We assessed the responsiveness of 66 candidate

John C. Brazner; Nicolas P. Danz; Anett S. Trebitz; Gerald J. Niemi; Ronald R. Regal; Tom Hollenhorst; George E. Host; Euan D. Reavie; Terry N. Brown; JoAnn M. Hanowski; Carol A. Johnston; Lucinda B. Johnson; Robert W. Howe; Jan J. H. Ciborowski

2007-01-01

216

Using a summary measure for multiple quality indicators in primary care: the Summary QUality InDex (SQUID)  

Microsoft Academic Search

BACKGROUND: Assessing the quality of primary care is becoming a priority in national healthcare agendas. Audit and feedback on healthcare quality performance indicators can help improve the quality of care provided. In some instances, fewer numbers of more comprehensive indicators may be preferable. This paper describes the use of the Summary Quality Index (SQUID) in tracking quality of care among

Paul J Nietert; Andrea M Wessell; Ruth G Jenkins; Chris Feifer; Lynne S Nemeth; Steven M Ornstein

2007-01-01

217

EVALUATING THE EFFECTIVENESS OF GREAT LAKES COASTAL WETLAND INDICATORS USING MULTIPLE TAXONOMIC GROUPS: GEOGRAPHIC AND GEOMORPHIC INFLUENCES  

EPA Science Inventory

This work arises from a MED collaboration with the GLEI consortium funded by and EPA Star Grant. Results confirm that developing effective indicators for Great Lakes coastal wetlands requires determination of the geographic range and ecosystem type where indicators are appropriat...

218

Generalized multiple model adaptive estimation  

NASA Astrophysics Data System (ADS)

In this dissertation a generalized multiple-model adaptive estimator (GMMAE) is presented that can be used to estimate the unknown noise statistics in filter designs. The assumed unknowns in the adaptive estimator are the process noise covariance elements. Multiple parameter elements are used to drive multiple-model parallel filters for state estimation. The current approach focuses on estimating the process noise covariance by sequentially updating weights associated with parameter elements through the calculation of the likelihood function of the measurement-minusestimate residuals, which also incorporates correlations between various measurement times. For linear Gaussian measurement processes the likelihood function is easily determined. For nonlinear Gaussian measurement processes, it is assumed that the linearized output sufficiently captures the statistics of the likelihood function by making the small noise assumption. A proof is provided that shows the convergence properties of the generalized approach versus the traditional multiple-model adaptive estimator (MMAE). Simulation results, involving a two-dimensional target tracking problem ans GPS-based position estimation problem using an extended Kalman filter, indicate that the new approach is able to correctly estimate the noise statistics.

Alsuwaidan, Badr N.

219

[Multiple autoimmune syndromes].  

PubMed

The possibility of three or more autoimmune diseases occurring in the same patient cannot be fortuitous and suggests a pathogenic relationship between each of them. In the light of 4 personal cases, the authors have recorded 87 reports of such associations in the literature, an analysis of which leads them to propose a classification of three types of multiple autoimmune syndrome. The grouping of these syndromes under a single heading should make the research and analysis of these morbid associations easier. Moreover, the classification adopted by the authors allows a more precise definition of patients with at least two autoimmune diseases and so helps to recognize the onset of a third autoimmune disease at a later date. Multiple autoimmune syndromes can be classified in 3 groups according to the prevalence of their associations one with another. Type I comprises myasthenia, thymoma, polymyositis and giant cell myocarditis, this association having a single pathogenic mechanism. Type II includes the Sjögren's syndrome, rhumatoid arthritis, primary biliary cirrhosis, scleroderma and autoimmune thyroid disorders. Type III groups together 10 autoimmune diseases (autoimmune thyroid disease, myasthenia and/or thymoma, Sjögren's syndrome, pernicious anaemia, idiopathic thrombocytopaenic purpura, Addison's disease, insulin-dependent diabetes, vitiligo, autoimmune haemolytic anaemia, systemic lupus erythematosus) for which a genetic predisposition (phenotype HLA B8 and/or DR3 or DR5) seems to be an important factor. PMID:3059902

Humbert, P; Dupond, J L

1988-01-01

220

Multiple antigen immunostaining procedures.  

PubMed

Detection of multiple antigens in the same tissue section can be done by combining a range of immunohisto/cytochemical techniques based either on light microscopic chromogenic precipitates or fluorochrome labeling. Light microscopic techniques preferred for this purpose use combinations of immunogold silver staining (black precipitate), immunoperoxidase, immunoalkaline phosphatase and immunogalactosidase methods using chromogens of different colors. Fluorochrome labels favored for these combinations include AMCA (blue), FITC (green), rhodamine (orange-red) and Cy5 (far red), their matching synthetic members from the Alexa series, or quantum dots. Antibodies directly labeled or those from noncross-reacting animal species (e.g., mouse, rabbit, goat, guinea pig etc.) can be applied simultaneously. When the antigens of interest are in separate cells or cell compartments (e.g., in cell membrane, cytoplasm or nucleus), and only cross-reacting antibodies are available, there have also been ways of avoiding unwanted cross-talk. These include the exploitation of the shielding effect of chromogens; inactivation of immuno-sequences of the first staining by using either acidic elution, formaldehyde fixation or microwave heating; combining unlabeled and hapten-labeled antibodies; or using labeled monovalent F(ab) secondary antibodies. In this chapter we briefly discuss the principle of multiple antigen immunolabeling and provide useful protocols for its performance. PMID:20012839

Krenacs, Tibor; Krenacs, Laszlo; Raffeld, Mark

2010-01-01

221

Phase-multiplication holography  

DOEpatents

This disclosure relates generally to nondestructive testing for identifying structural characteristics of an object by scanned holographic techniques using a known source of radiation, such as electromagnetic or acoustical radiation. It is an object of this invention to provide an apparatus and method for synthetic aperture expansion in holographic imaging applications to construct fringe patterns capable of holographic reproduction where aperture restrictions in nondestructive testing applications would conventionally make such imaging techniques impossible. The apparatus and method result in the production of a sharply defined frontal image of structural characteristics which could not otherwise be imaged because they occur either near the surface of the object or are confined by geometry restricting aperture dimensions available for scanning purposes. The depth of the structural characteristic below the surface of the object can also be determined by the reconstruction parameters which produce the sharpest focus. Lateral resolution is established by simulated reduction in the radiation wavelength and may easily be an order of magnitude less than the electromagnetic wavelength in the material or 2 times the standard depth of penetration. Since the phase multiplication technique is performed on the detected data, the penetration depth available due to the longer wavelength signals applied to the test object remains unchanged. The phase multiplication technique can also be applied to low frequency acoustic holography, resulting in a test which combines excellent penetration of difficult materials with high resolution images.

Collins, H.D.; Prince, J.M.; Davis, T.J.

1982-01-25

222

Multiple capillary biochemical analyzer  

DOEpatents

A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being analyzed, using a modified sheath flow cuvette. A linear or rectangular array of capillaries is introduced into a rectangular flow chamber. Sheath fluid draws individual sample streams through the cuvette. The capillaries are closely and evenly spaced and held by a transparent retainer in a fixed position in relation to an optical detection system. Collimated sample excitation radiation is applied simultaneously across the ends of the capillaries in the retainer. Light emitted from the excited sample is detected by the optical detection system. The retainer is provided by a transparent chamber having inward slanting end walls. The capillaries are wedged into the chamber. One sideways dimension of the chamber is equal to the diameter of the capillaries and one end to end dimension varies from, at the top of the chamber, slightly greater than the sum of the diameters of the capillaries to, at the bottom of the chamber, slightly smaller than the sum of the diameters of the capillaries. The optical system utilizes optic fibres to deliver light to individual photodetectors, one for each capillary tube. A filter or wavelength division demultiplexer may be used for isolating fluorescence at particular bands.

Dovichi, Norman J. (Edmonton, CA); Zhang, Jian Z. (Edmonton, CA)

1995-01-01

223

Multiple capillary biochemical analyzer  

DOEpatents

A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being analyzed, using a modified sheath flow cuvette. A linear or rectangular array of capillaries is introduced into a rectangular flow chamber. Sheath fluid draws individual sample streams through the cuvette. The capillaries are closely and evenly spaced and held by a transparent retainer in a fixed position in relation to an optical detection system. Collimated sample excitation radiation is applied simultaneously across the ends of the capillaries in the retainer. Light emitted from the excited sample is detected by the optical detection system. The retainer is provided by a transparent chamber having inward slanting end walls. The capillaries are wedged into the chamber. One sideways dimension of the chamber is equal to the diameter of the capillaries and one end to end dimension varies from, at the top of the chamber, slightly greater than the sum of the diameters of the capillaries to, at the bottom of the chamber, slightly smaller than the sum of the diameters of the capillaries. The optical system utilizes optic fibers to deliver light to individual photodetectors, one for each capillary tube. A filter or wavelength division demultiplexer may be used for isolating fluorescence at particular bands. 21 figs.

Dovichi, N.J.; Zhang, J.Z.

1995-08-08

224

Multiple Representations of Buoyancy  

NASA Astrophysics Data System (ADS)

For many students the concept of buoyancy falls under a category that can be loosely described as ``knowing it when they see it.'' Unfortunately some of the misconceptions this generates are that ``objects float because they are light'' and ``objects float because they are full of air'' [1]. Those these can some times be true, these descriptions are vague at best, and frequently can be wrong. Part of these misconceptions may stem from incomplete immersion of the object in the fluid and the vector nature of forces. We describe a demonstration/lab activity to help students make sense about relationship between the tension on and weight of an object immersed in water. The activity is in rich in multiple representations, graphical, diagrammatical as well as mathematical. A simple four question multiple choice pre/post test survey has been developed to evaluate the effectiveness of the lab activity.[4pt] [1] Bruce Harlan ``Diving Science'', www.stmatthewsschool.com/deep/pdfs/Diving%20Science.pdf

Oliviera, Jessica; Weglarz, Meredith; Vesenka, James

2009-10-01

225

QSRR Study of GC Retention Indices of Essential-Oil Compounds by Multiple Linear Regression with a Genetic Algorithm  

Microsoft Academic Search

Quantitative structure–retention relationships (QSRR) for components of the essential oil of the plant Bidens pilosa Linn. var. Radiata were studied to enable prediction of their retention indices (I\\u000a R). A data set was selected consisting of the retention indices of 44 components of the essential oil with a range of more\\u000a than 635 units. A suitable set of molecular descriptors

Siavash Riahi; Mohammad Reza Ganjali; Eslam Pourbasheer; Parviz Norouzi

2008-01-01

226

Evaluation of the Appropriateness of Multiple Symptom Validity Indices in Psychotic and Non-Psychotic Psychiatric Populations  

Microsoft Academic Search

Although it is recognized that significant cognitive deficits are inherent in many psychiatric disorders, there is minimal research on whether the deficits can cause a failing score on symptom validity tests (SVTs). The performances of 104 and 178 patients with psychotic disorders and non-psychotic psychiatric disorders, respectively, on seven SVTs were examined. Analyses indicate that most of these SVTs have

Ryan W. Schroeder; Paul S. Marshall

2011-01-01

227

Base Rates, Multiple Indicators, and Comprehensive Forensic Evaluations: Why Sexualized Behavior Still Counts in Assessments of Child Sexual Abuse Allegations  

ERIC Educational Resources Information Center

|Developmentally inappropriate sexual behavior has long been viewed as a possible indicator of child sexual abuse. In recent years, however, the utility of sexualized behavior in forensic assessments of alleged child sexual abuse has been seriously challenged. This article addresses a number of the concerns that have been raised about the…

Everson, Mark D.; Faller, Kathleen Coulborn

2012-01-01

228

[Treatment of isolated and multiple ligament injuries of the knee: anatomy, biomechanics, diagnosis, indications for repair, surgery].  

PubMed

Complex knee ligament injuries are characterized by simultaneous rupture of the anterior cruciate ligament (ACL) and/or the posterior cruciate ligament (PCL) and at least one collateral ligament. Isolated injury to the medial collateral ligament (MCL) and PCL have a high healing capacity and can be treated conservatively in many cases. Ruptures of the MCL can also be treated conservatively in complex injuries if the cruciate ligaments are reconstructed. Ruptures of the lateral structures usually need surgical reconstruction. Indications for acute surgical repair include meniscus dislocation, entrapment of collateral ligament portions in the joint, knee dislocation with severe knee instability, and displaced bony avulsions. The anatomy of the knee ligaments must be carefully respected in surgical reconstruction. Acute repair of collateral ligament injuries is possible only in the first 2 weeks after trauma. Acute arthroscopy is indicated only in combination with reconstructive surgery. PMID:19430762

Yastrebov, O; Lobenhoffer, P

2009-06-01

229

Base rates, multiple indicators, and comprehensive forensic evaluations: why sexualized behavior still counts in assessments of child sexual abuse allegations.  

PubMed

Developmentally inappropriate sexual behavior has long been viewed as a possible indicator of child sexual abuse. In recent years, however, the utility of sexualized behavior in forensic assessments of alleged child sexual abuse has been seriously challenged. This article addresses a number of the concerns that have been raised about the diagnostic value of sexualized behavior, including the claim that when population base rates for abuse are properly taken into account, the diagnostic value of sexualized behavior is insignificant. This article also identifies a best practice comprehensive evaluation model with a methodology that is effective in mitigating such concerns. PMID:22339424

Everson, Mark D; Faller, Kathleen Coulborn

2012-01-01

230

Dancing with Multiple Partners  

NSDL National Science Digital Library

Transmembrane proteins, such as G protein-coupled receptors (GPCRs) and integrins, activate intracellular signaling pathways through interactions with downstream binding partners. Woodside discusses two examples in which GPCRs and integrins interact in a noncompeting manner with more than one partner. The specific GPCR described is the thrombin receptor, in experiments where G protein peptides selectively block signaling through a particular G protein that does not appear to inhibit coupling of the receptor to other G proteins. The second system described is the αIIbβ3 integrin and its activation of the nonreceptor tyrosine kinase Syk. Syk appeared capable of interacting with both the integrin and intracellular domains of immune response receptors, because binding of Syk to the integrin was not inhibited by peptides based on the Syk binding site in immune response receptors. Thus, multiple, noncompeting binding partners add to the complexity of signal transduction outputs from a single receptor complex.

Darren G. Woodside (Texas Biotechnology Corporation; REV)

2002-03-19

231

Bayesian Semiparametric Multiple Shrinkage  

PubMed Central

Summary High-dimensional and highly correlated data leading to non- or weakly identified effects are commonplace. Maximum likelihood will typically fail in such situations and a variety of shrinkage methods have been proposed. Standard techniques, such as ridge regression or the lasso, shrink estimates toward zero, with some approaches allowing coefficients to be selected out of the model by achieving a value of zero. When substantive information is available, estimates can be shrunk to nonnull values; however, such information may not be available. We propose a Bayesian semiparametric approach that allows shrinkage to multiple locations. Coefficients are given a mixture of heavy-tailed double exponential priors, with location and scale parameters assigned Dirichlet process hyperpriors to allow groups of coefficients to be shrunk toward the same, possibly nonzero, mean. Our approach favors sparse, but flexible, structure by shrinking toward a small number of random locations. The methods are illustrated using a study of genetic polymorphisms and Parkinson’s disease.

Dunson, David B.

2013-01-01

232

MULTIPLE SPARK GAP SWITCH  

DOEpatents

A multiple spark gap switch of unique construction is described which will permit controlled, simultaneous discharge of several capacitors into a load. The switch construction includes a disc electrode with a plurality of protuberances of generally convex shape on one surface. A firing electrode is insulatingly supponted In each of the electrode protuberances and extends substantially to the apex thereof. Individual electrodes are disposed on an insulating plate parallel with the disc electrode to form a number of spark gaps with the protuberances. These electrodes are each connected to a separate charged capacitor and when a voltage ls applied simultaneously between the trigger electrodes and the dlsc electrode, each spark gap fires to connect its capacitor to the disc electrode and a subsequent load.

Schofield, A.E.

1958-07-22

233

Mixed Mode Matrix Multiplication  

SciTech Connect

In modern clustering environments where the memory hierarchy has many layers (distributed memory, shared memory layer, cache,...), an important question is how to fully utilize all available resources and identify the most dominant layer in certain computations. When combining algorithms on all layers together, what would be the best method to get the best performance out of all the resources we have? Mixed mode programming model that uses thread programming on the shared memory layer and message passing programming on the distributed memory layer is a method that many researchers are using to utilize the memory resources. In this paper, they take an algorithmic approach that uses matrix multiplication as a tool to show how cache algorithms affect the performance of both shared memory and distributed memory algorithms. They show that with good underlying cache algorithm, overall performance is stable. When underlying cache algorithm is bad, superlinear speedup may occur, and an increasing number of threads may also improve performance.

Meng-Shiou Wu; Srinivas Aluru; Ricky A. Kendall

2004-09-30

234

Headache in multiple sclerosis.  

PubMed

Pain, including headache, is a frequent complaint of individuals with multiple sclerosis (MS). Prevalence of headache in patients with MS was reported to be higher than 50%, but it is uncertain if this is different than what is seen in the general population. Nonetheless, it is possible that MS and headaches are comorbid. Case reports illustrated that isolated MS lesions (eg, in "strategic" regions like the midbrain) may cause severe headaches often resembling migraine. Furthermore, the role of MS disease-modifying agents needs to be taken into consideration. Mode of action and side effect profiles differ, and treatment per se may sometimes trigger headache in patients with MS. Thorough evaluation of headache in patients with MS is crucial to optimize patient management to help improve quality of life. PMID:20514531

Putzki, Norman; Katsarava, Zaza

2010-08-01

235

Phylogeographical Analysis of mtDNA Data Indicates Postglacial Expansion from Multiple Glacial Refugia in Woodland Caribou (Rangifer tarandus caribou)  

PubMed Central

Glacial refugia considerably shaped the phylogeographical structure of species and may influence intra-specific morphological, genetic, and adaptive differentiation. However, the impact of the Quaternary ice ages on the phylogeographical structure of North American temperate mammalian species is not well-studied. Here, we surveyed ?1600 individuals of the widely distributed woodland caribou (Rangifer tarandus caribou) using mtDNA control region sequences to investigate if glacial refugia contributed to the phylogeographical structure in this subspecies. Phylogenetic tree reconstruction, a median-joining network, and mismatch distributions supported postglacial expansions of woodland caribou from three glacial refugia dating back to 13544–22005 years. These three lineages consisted almost exclusively of woodland caribou mtDNA haplotypes, indicating that phylogeographical structure was mainly shaped by postglacial expansions. The putative centres of these lineages are geographically separated; indicating disconnected glacial refugia in the Rocky Mountains, east of the Mississippi, and the Appalachian Mountains. This is in congruence with the fossil record that caribou were distributed in these areas during the Pleistocene. Our results suggest that the last glacial maximum substantially shaped the phylogeographical structure of this large mammalian North American species that will be affected by climatic change. Therefore, the presented results will be essential for future conservation planning in woodland caribou.

Klutsch, Cornelya F. C.; Manseau, Micheline; Wilson, Paul J.

2012-01-01

236

Phylogeographical analysis of mtDNA data indicates postglacial expansion from multiple glacial refugia in woodland caribou (Rangifer tarandus caribou).  

PubMed

Glacial refugia considerably shaped the phylogeographical structure of species and may influence intra-specific morphological, genetic, and adaptive differentiation. However, the impact of the Quaternary ice ages on the phylogeographical structure of North American temperate mammalian species is not well-studied. Here, we surveyed ~1600 individuals of the widely distributed woodland caribou (Rangifer tarandus caribou) using mtDNA control region sequences to investigate if glacial refugia contributed to the phylogeographical structure in this subspecies. Phylogenetic tree reconstruction, a median-joining network, and mismatch distributions supported postglacial expansions of woodland caribou from three glacial refugia dating back to 13544-22005 years. These three lineages consisted almost exclusively of woodland caribou mtDNA haplotypes, indicating that phylogeographical structure was mainly shaped by postglacial expansions. The putative centres of these lineages are geographically separated; indicating disconnected glacial refugia in the Rocky Mountains, east of the Mississippi, and the Appalachian Mountains. This is in congruence with the fossil record that caribou were distributed in these areas during the Pleistocene. Our results suggest that the last glacial maximum substantially shaped the phylogeographical structure of this large mammalian North American species that will be affected by climatic change. Therefore, the presented results will be essential for future conservation planning in woodland caribou. PMID:23285137

Klütsch, Cornelya F C; Manseau, Micheline; Wilson, Paul J

2012-12-21

237

Tuberculosis affecting multiple vertebral bodies.  

PubMed

Spinal tuberculosis usually occurs in a single vertebral body or two to three adjacent vertebrae; it rarely occurs in multiple vertebral bodies. Surgery is indicated in cases that do not improve with conservative therapy, or when paralysis is evident. Two cases regarding patients with spinal tuberculosis in multiple vertebral bodies on whom surgery was performed are reported. Case 1, the patient was a 77-year-old woman with spinal tuberculosis in four vertebral bodies from the lower thoracic to the lumbar spine. As she had pronounced lower back pain, posterolateral fusion with a pedicle screw was performed. Case 2, the patient was a 29-year-old Indonesian man with spinal tuberculosis in 17 vertebral bodies of the spine who was unable to stand due to paralysis of both legs, thus posterolateral fusion with a pedicle screw was performed. Good results were obtained from tuberculostatic drug therapy and surgical instrumentation. PMID:24066219

Baba, Hideo; Tagami, Atsushi; Adachi, Shinji; Hiura, Takeshi; Osaki, Makoto

2013-09-04

238

Tuberculosis Affecting Multiple Vertebral Bodies  

PubMed Central

Spinal tuberculosis usually occurs in a single vertebral body or two to three adjacent vertebrae; it rarely occurs in multiple vertebral bodies. Surgery is indicated in cases that do not improve with conservative therapy, or when paralysis is evident. Two cases regarding patients with spinal tuberculosis in multiple vertebral bodies on whom surgery was performed are reported. Case 1, the patient was a 77-year-old woman with spinal tuberculosis in four vertebral bodies from the lower thoracic to the lumbar spine. As she had pronounced lower back pain, posterolateral fusion with a pedicle screw was performed. Case 2, the patient was a 29-year-old Indonesian man with spinal tuberculosis in 17 vertebral bodies of the spine who was unable to stand due to paralysis of both legs, thus posterolateral fusion with a pedicle screw was performed. Good results were obtained from tuberculostatic drug therapy and surgical instrumentation.

Baba, Hideo; Tagami, Atsushi; Adachi, Shinji; Hiura, Takeshi

2013-01-01

239

Applying Multiple Query Optimization in Mobile Databases  

Microsoft Academic Search

We apply multiple query optimization to batches of pull (on-demand) requests in a mobile database system. The resulting view can answer several queries at once, and it is broadcast on a view channel dedicated to common answers of multiple queries rather than over individual downlink channels. A performance study is conducted that simulates different query workloads. The results indicate a

Rajeswari Malladi; Karen C. Davis

2003-01-01

240

Multiple finite Riemann zeta functions  

Microsoft Academic Search

Observing a multiple version of the divisor function we introduce a new zeta function which we call a multiple finite Riemann zeta function. We utilize some $q$-series identity for proving the zeta function has an Euler product and then, describe the location of zeros. We study further multi-variable and multi-parameter versions of the multiple finite Riemann zeta functions and their

Kazufumi Kimoto; Nobushige Kurokawa; Sho Matsumoto; Masato Wakayama

2005-01-01

241

Sphingolipids in multiple sclerosis  

PubMed Central

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the CNS. Oligodendrocytes, the myelin forming cells of the central nervous system (CNS), are target cells in MS. Although the etiology of MS is poorly known, new insights suggest oligodendrocyte apoptosis as one of the critical events followed by glial activation and infiltration of lymphocytes and macrophages. A major breakthrough in delineation of the mechanism of cell death, perivascular cuffing and glial activation came from elucidation of the sphingolipid signal transduction pathway. The sphingolipid signal transduction pathway induces apoptosis, differentiation, proliferation, and growth arrest depending upon cell and receptor types, and downstream targets. Sphingomyelin, a major component of myelin membrane formed by mature oligodendrocytes, is abundant in the CNS and ceramide, its primary catabolic product released by activation of either neutral or acidic sphingomyelinase, serves as a potential lipid second messenger or mediator molecule modulating diverse cellular signaling pathways. Similarly, under certain conditions, sphingosine produced from ceramide by ceramidase is phosphorylated by sphingosine kinases to sphingosine-1 phosphate, another potent second messenger molecule. Both ceramide and sphingosine-1 phosphate regulate life and death of many cell types including brain cells and participate in pathogenic processes of MS. In this review, we have made an honest attempt to compile recent findings made by others and us relating to the role of sphingolipids in the disease process of MS.

Jana, Arundhati; Pahan, Kalipada

2010-01-01

242

Multiple stage railgun  

DOEpatents

A multiple stage magnetic railgun accelerator (10) for accelerating a projectile (15) by movement of a plasma arc (13) along the rails (11,12). The railgun (10) is divided into a plurality of successive rail stages (10a-n) which are sequentially energized by separate energy sources (14a-n) as the projectile (15) moves through the bore (17) of the railgun (10). Propagation of energy from an energized rail stage back towards the breech end (29) of the railgun (10) can be prevented by connection of the energy sources (14a-n) to the rails (11,12) through isolation diodes (34a-n). Propagation of energy from an energized rail stage back towards the breech end of the railgun can also be prevented by dividing the rails (11,12) into electrically isolated rail sections (11a-n, 12a-n). In such case means (55a-n) are used to extinguish the arc at the end of each energized stage and a fuse (31) or laser device (61) is used to initiate a new plasma arc in the next energized rail stage.

Hawke, Ronald S. (Livermore, CA); Scudder, Jonathan K. (Pleasanton, CA); Aaland, Kristian (Livermore, CA)

1982-01-01

243

[Multiple system atrophy (MSA)].  

PubMed

The clinical and pathological features of 47 cases of multiple system atrophy (MSA) were analyzed. The mean age of onset was 56.7 (range 40 to approximately 76) years and mean survival was 5.7 (range 1.5 to approximately 12) years. Parkinsonism occurred in 31 cases. Helpful early points to the diagnosis included rigid-akinetic type, rapid progression, failure to respond to L-DOPA and other signs such as autoromic dysfunction, cerebellar ataxia and pyramidal signs, but these were not always present. T2 weighted MR images demonstrated decreased signal in the putamen and/or slit-hyperintensity in the outer margin of the putamen. These clinical and MRI findings are useful in the differential diagnosis between Parkinson's disease and MSA. Glial cytoplasmic inclusions (GCIs) were found in all 21 cases, but not in control brains. Several types of neuroral inclusion were also observed; large neuroral cytoplasmic, small neuroral cytoplasmic and nuclear inclusions. GCIs were labeled by antiubiquitin, anti-alpha and beta-tubulin and antitau antibodies. Large neuronal cytoplasmic inclusions (NCIs) observed in the pontine nuclei were positive with only antiubiquitin antibody. PMID:8752426

Riku, S

1995-12-01

244

"Undiagnosing" multiple sclerosis  

PubMed Central

Objective: To describe the clinical characteristics of encounters with patients misdiagnosed with multiple sclerosis (MS). Methods: A cross-sectional Internet-based physician survey of MS specialists was performed. Results: The response rate for the survey was 50.4%. Of those who responded, the majority (95%) reported having evaluated 1 or more patients who had been diagnosed with MS, but who they strongly felt did not have MS, within the last year. The majority of respondents (>90%) also reported the use of disease-modifying therapy in a proportion of these patients. Most respondents (94%) found clinical encounters with these patients equally or more challenging than giving a new diagnosis of MS. Fourteen percent of respondents reported that they did not always inform such patients of their opinion that they did not have MS. Conclusions: The misdiagnosis of MS is common and has significant consequences for patient care and health care system costs. Caring for a patient with a misdiagnosis of MS is challenging, and at times honest disclosure of a misdiagnosis represents an important ethical concern for neurologists. More data are needed on this patient population to improve diagnostic acumen and the care of these patients.

Klein, Eran P.; Bourdette, Dennis

2012-01-01

245

Thermoregulation in multiple sclerosis  

PubMed Central

Multiple sclerosis (MS) is a progressive neurological disorder that disrupts axonal myelin in the central nervous system. Demyelination produces alterations in saltatory conduction, slowed conduction velocity, and a predisposition to conduction block. An estimated 60–80% of MS patients experience temporary worsening of clinical signs and neurological symptoms with heat exposure. Additionally, MS may produce impaired neural control of autonomic and endocrine functions. This review focuses on five main themes regarding the current understanding of thermoregulatory dysfunction in MS: 1) heat sensitivity; 2) central regulation of body temperature; 3) thermoregulatory effector responses; 4) heat-induced fatigue; and 5) countermeasures to improve or maintain function during thermal stress. Heat sensitivity in MS is related to the detrimental effects of increased temperature on action potential propagation in demyelinated axons, resulting in conduction slowing and/or block, which can be quantitatively characterized using precise measurements of ocular movements. MS lesions can also occur in areas of the brain responsible for the control and regulation of body temperature and thermoregulatory effector responses, resulting in impaired neural control of sudomotor pathways or neural-induced changes in eccrine sweat glands, as evidenced by observations of reduced sweating responses in MS patients. Fatigue during thermal stress is common in MS and results in decreased motor function and increased symptomatology likely due to impairments in central conduction. Although not comprehensive, some evidence exists concerning treatments (cooling, precooling, and pharmacological) for the MS patient to preserve function and decrease symptom worsening during heat stress.

Wilson, Thad E.; White, Andrea T.; Frohman, Elliot M.

2010-01-01

246

Thermoregulation in multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is a progressive neurological disorder that disrupts axonal myelin in the central nervous system. Demyelination produces alterations in saltatory conduction, slowed conduction velocity, and a predisposition to conduction block. An estimated 60-80% of MS patients experience temporary worsening of clinical signs and neurological symptoms with heat exposure. Additionally, MS may produce impaired neural control of autonomic and endocrine functions. This review focuses on five main themes regarding the current understanding of thermoregulatory dysfunction in MS: 1) heat sensitivity; 2) central regulation of body temperature; 3) thermoregulatory effector responses; 4) heat-induced fatigue; and 5) countermeasures to improve or maintain function during thermal stress. Heat sensitivity in MS is related to the detrimental effects of increased temperature on action potential propagation in demyelinated axons, resulting in conduction slowing and/or block, which can be quantitatively characterized using precise measurements of ocular movements. MS lesions can also occur in areas of the brain responsible for the control and regulation of body temperature and thermoregulatory effector responses, resulting in impaired neural control of sudomotor pathways or neural-induced changes in eccrine sweat glands, as evidenced by observations of reduced sweating responses in MS patients. Fatigue during thermal stress is common in MS and results in decreased motor function and increased symptomatology likely due to impairments in central conduction. Although not comprehensive, some evidence exists concerning treatments (cooling, precooling, and pharmacological) for the MS patient to preserve function and decrease symptom worsening during heat stress. PMID:20671034

Davis, Scott L; Wilson, Thad E; White, Andrea T; Frohman, Elliot M

2010-07-29

247

Immunopathogenesis of multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is a suspected autoimmune disease in which myelin-specific CD4+ and CD8+ T cells enter the central nervous system (CNS) and initiate an inflammatory response directed against myelin and other components of the CNS. Acute MS exacerbations are believed be the result of active inflammation, and progression of disability is generally believed to reflect accumulation of damage to the CNS, particularly axonal damage. Over the last several years, the pathophysiology of MS is being appreciated to be much more complex, and it appears that the development of the MS plaque involves a large number of cell populations, including CD8+ T lymphocytes, B cells, and Th17 cells (a population of helper T cells that secrete the inflammatory cytokine IL-17). The axonal transection and degeneration that is thought to represent the basis for progressive MS is now recognized to begin early in the disease process and to continue in the progressive forms of the disease. Molecules important for limiting aberrant neural connections in the CNS have been identified, which suppress axonal sprouting and regeneration of transected axons within the CNS. Pathways have also been identified that prevent remyelination of the MS lesion by oligodendrocyte precursors. Novel neuroimaging methodologies and potential biomarkers are being developed to monitor various aspects of the disease process in MS. As we identify the pathways responsible for the clinical phenomena of MS, we will be able to develop new therapeutic strategies for this disabling illness of young adults. PMID:20182567

Racke, Michael K

2009-10-01

248

Apoptosis of Multiple Myeloma  

PubMed Central

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. MM cells localize to the bone marrow, where cell adhesion–mediated autocrine or paracrine activation of various cytokines, such as interleukin 6, insulin-like growth factor 1, and interferon ?, results in their accumulation mainly because of loss of critical apoptotic controls. Resistance to apoptosis, a genetically regulated cell death process, may play a critical role in both pathogenesis and resistance to treatment of MM. Abnormalities in regulation and execution of apoptosis can contribute to tumor initiation, progression, as well as to tumor resistance to various therapeutic agents. Apoptosis is executed via 2 main pathways that lead to activation of caspases: the death receptor (extrinsic) pathway and the mitochondrial (intrinsic) pathway. Ionizing radiation and chemotherapeutic agents act primarily through the intrinsic pathway, in which mitochondria play the central role. Various therapeutic modalities that are effective in MM modulate levels of the proapoptotic and antiapoptotic Bcl-2 family of proteins and of inhibitors of apoptosis, expression of which is primarily regulated by p53, nuclear factor ?B, and STAT (signal transducers and activators of transcription) factors. This review focuses on the key concepts and some of the most recent studies of signaling pathways regulated in MM and summarizes what is known about the clinical role of these pathways.

Oancea, Marcela; Mani, Aruna; Hussein, Mohamad A; Almasan, Alexandru

2005-01-01

249

MULTIPLE SHAFT TOOL HEAD  

DOEpatents

An improved tool head arrangement is designed for the automatic expanding of a plurality of ferruled tubes simultaneously. A plurality of output shafts of a multiple spindle drill head are driven in unison by a hydraulic motor. A plurality of tube expanders are respectively coupled to the shafts through individual power train arrangements. The axial or thrust force required for the rolling operation is provided by a double acting hydraulic cylinder having a hollow through shaft with the shaft cooperating with an internally rotatable splined shaft slidably coupled to a coupling rigidly attached to the respectlve output shaft of the drill head, thereby transmitting rotary motion and axial thrust simultaneously to the tube expander. A hydraulic power unit supplies power to each of the double acting cylinders through respective two-position, four-way valves, under control of respective solenoids for each of the cylinders. The solenoids are in turn selectively controlled by a tool selection control unit which in turn is controlled by signals received from a programmed, coded tape from a tape reader. The number of expanders that are extended in a rolling operation, which may be up to 42 expanders, is determined by a predetermined program of operations depending upon the arrangement of the ferruled tubes to be expanded in the tube bundle. The tape reader also supplies dimensional information to a machine tool servo control unit for imparting selected, horizontal and/or vertical movement to the tool head assembly. (AEC)

Colbert, H.P.

1962-10-23

250

Biomarkers for multiple sclerosis.  

PubMed

The pursuit of personalized medicine requires the development of biomarkers to predict disease course, monitor disease evolution, stratify patient subgroups by disease activity and to predict and monitor response to therapies. Multiple sclerosis (MS) is a common neurological disease in young adults with an unpredictable course that may be associated with significant disability, diminishing the patient's quality of life. Currently, disease prognosis is based on clinical information (relapse rate and disability scales) and diagnostic tests (brain MRI or the presence of oligoclonal bands in the cerebrospinal fluid). However, the ability of neurologists to make an accurate prognosis is very limited based on such information, a situation perceived by patients as one of their biggest concerns. Although many recent studies have identified different molecules and imaging techniques associated with the course of MS, in most cases the diagnostic accuracy of such technologies has not been properly assessed. This shortcoming is partly due to the failure to validate such biomarkers, which impedes their application in clinical practice. However, the recent validation of anti-aquaporin-4 antibodies for Devic's disease and the development of optic coherent tomography for MS, are examples of the benefits that the development of MS biomarkers can offer. Indeed, it may currently be necessary to redress the bias in research towards clinical validation rather than discovery in order to promote translational research and improve patient's quality of life. PMID:21152453

Villoslada, Pablo

2010-11-01

251

Exciton Multiplication from First Principles.  

PubMed

Third-generation photovolatics require demanding cost and power conversion efficiency standards, which may be achieved through efficient exciton multiplication. Therefore, generating more than one electron-hole pair from the absorption of a single photon has vast ramifications on solar power conversion technology. Unlike their bulk counterparts, irradiated semiconductor quantum dots exhibit efficient exciton multiplication, due to confinement-enhanced Coulomb interactions and slower nonradiative losses. The exact characterization of the complicated photoexcited processes within quantum-dot photovoltaics is a work in progress. In this Account, we focus on the photophysics of nanocrystals and investigate three constituent processes of exciton multiplication, including photoexcitation, phonon-induced dephasing, and impact ionization. We quantify the role of each process in exciton multiplication through ab initio computation and analysis of many-electron wave functions. The probability of observing a multiple exciton in a photoexcited state is proportional to the magnitude of electron correlation, where correlated electrons can be simultaneously promoted across the band gap. Energies of multiple excitons are determined directly from the excited state wave functions, defining the threshold for multiple exciton generation. This threshold is strongly perturbed in the presence of surface defects, dopants, and ionization. Within a few femtoseconds following photoexcitation, the quantum state loses coherence through interactions with the vibrating atomic lattice. The phase relationship between single excitons and multiple excitons dissipates first, followed by multiple exciton fission. Single excitons are coupled to multiple excitons through Coulomb and electron-phonon interactions, and as a consequence, single excitons convert to multiple excitons and vice versa. Here, exciton multiplication depends on the initial energy and coupling magnitude and competes with electron-phonon energy relaxation. Multiple excitons are generated through impact ionization within picoseconds. The basis of exciton multiplication in quantum dots is the collective result of photoexcitation, dephasing, and nonadiabatic evolution. Each process is characterized by a distinct time-scale, and the overall multiple exciton generation dynamics is complete by about 10 ps. Without relying on semiempirical parameters, we computed quantum mechanical probabilities of multiple excitons for small model systems. Because exciton correlations and coherences are microscopic, quantum properties, results for small model systems can be extrapolated to larger, realistic quantum dots. PMID:23459543

Jaeger, Heather M; Hyeon-Deuk, Kim; Prezhdo, Oleg V

2013-03-01

252

Channel aware scheduling for multiple antenna multiple access channels  

Microsoft Academic Search

In this paper, we study the optimum transmission strategy of the multiple access channel in a cellular system in which the base station has multiple antennas. Recently, scheduling algorithms incorporating both the physical and data link layer were proposed e.g. in H. Boche and M. Wiczanowski, (2003), M. J. Neely, et al., (Feb. 2003), E. M. Yeh, (2002), for the

H. Boche; E. A. Jorswieck; T. Haustein

2003-01-01

253

[Multiple system atrophy].  

PubMed

Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder of unknown etiology. It is the most frequent disorder among atypical parkinsonism with an estimated prevalence of 2 to 5 per 100 000 inhabitants. The clinical symptoms are rapidly progressing with a mean survival ranging between 6 to 9 years. The diagnosis is based on consensus criteria that have been revised in 2008. The diagnostic criteria allow defining "possible", "probable" and "definite" MSA. The latter requires post mortem confirmation of striatonigral and olivopontocerebellar degeneration with alpha-synuclein containing glial cytoplasmic inclusions. The diagnosis of "possible" and "probable" MSA is based on the variable presence and severity of parkinsonism, cerebellar dysfunction, autonomic failure and pyramidal signs. According to the revised criteria, atrophy of putamen, pons, middle cerebellar peduncle (MCP) or cerebellum on brain magnetic resonance imaging are considered to be additional features for the diagnosis of "possible" MSA. T2-weighted brain imaging may further reveal a putaminal hypointensity, a hyperintense lateral putaminal rim, the so called "hot cross bun sign" and MCP hyperintensities. Cardiovascular examination, urodynamic testing and anal sphincter electromyography may be helpful for the diagnosis of autonomic failure. Some patients may respond to levodopa, but usually to a lesser extent than those suffering from Parkinson's disease, and high doses are already required in early disease stages. No specific therapy is available for cerebellar dysfunction, while effective treatments exist for urinary and cardiovascular autonomic failure. Physical therapy may help to improve the difficulties of gait and stance, and to prevent their complications. In later disease stages, speech therapy becomes necessary for the treatment of dysarthria and dysphagia. Percutaneous gastrostomy is sometimes necessary in patients with severe dysphagia. Beyond these strategies, psychological support, social care and occupational therapy to adapt the environment to the patient's disability are prerequisites for improving the quality of life in MSA patients. PMID:20739256

Damon-Perrière, Nathalie; Tison, François; Meissner, Wassilios G

2010-09-01

254

Homeopathy in multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is the most common disease of the central nervous system affecting people between the ages of 20 and 40 years in the UK, Northern Europe and the USA. No definitive treatment yet exists to halt the almost inevitable decline in function and accumulation of disability over the years in sufferers. Management is largely directly of symptoms which arise variably in the course of the condition. Such problems as urinary incontinence, sexual dysfunction, cramps and spasms, tremor and trigeminal neuralgia can often be helped to some extent using conventional therapies. These treatments though are not effective in everyone, or cause unacceptable side-effects and there are some commonly reported symptoms, such as fatigue or emotional lability for which there are no generally accepted treatments. Here, a knowledge of complementary and alternative medicine (CAM) can bring benefits to the person with MS. CAM is widely used by people with MS and some studies in this area are briefly summarised. It is interesting to reflect what lies behind all this CAM use and what that might tell conventional medicine about just what it is the MS sufferer really wants from their carers. Homeopathy is a form of CAM unique in the UK in having been available in the NHS since the foundation in 1948. Medical homeopaths in the UK have always been concerned with the integration of the best of conventional and complementary treatments for the benefit of their patients. Glasgow Homeopathic Hospital has around 100 admissions each year of people with MS at different stages of the condition and aims at an integrated response to their distress. Different therapeutic modalities are employed, but a homeopathic approach in particular is of benefit in MS. By its nature, it is a whole-person approach and allows for complete individualisation of treatment, taking account of the minutiae of someone's life. This is discussed and some examples of homeopathic treatments, which seem to be more generalisable for commonly encountered MS symptoms, are given. PMID:12604318

Whitmarsh, Thomas E

2003-02-01

255

Sarcoidosis presenting with multiple tattoo granulomata  

Microsoft Academic Search

A patient with sarcoidosis, multiple tattoo granulomata and arthritis is described. A combination of tattoo granulomata unrelated to any one colour in the tattoo and granulomatous inflammation elsewhere is indicative of sarcoidosis.

J. M. I. Iveson; J. A. Cotterill; V. Wright

1975-01-01

256

Internal fixation in patients with multiple injuries.  

PubMed

The hypothesis is advanced that there are additional and exceptional indications for the use of internal fixation in the patient with multiple injuries. Eleven case studies of patients who sustained major injuries support this hypothesis. PMID:6629496

Merriam, W F; Mifsud, R P

1983-09-01

257

Multiplication Fact Fluency Using Doubles  

ERIC Educational Resources Information Center

Not knowing multiplication facts creates a gap in a student's mathematics development and undermines confidence and disposition toward further mathematical learning. Learning multiplication facts is a first step in proportional reasoning, "the capstone of elementary arithmetic and the gateway to higher mathematics" (NRC 2001, p. 242). Proportional…

Flowers, Judith M.; Rubenstein, Rheta N.

2010-01-01

258

Symptomatic therapy in multiple sclerosis  

PubMed Central

Multiple sclerosis is the most common disabling neurological disease of young adults. The ability to impact the quality of life of patients with multiple sclerosis should not only incorporate therapies that are disease modifying, but should also include a course of action for the global multidisciplinary management focused on quality of life and functional capabilities.

Frohman, Teresa C.; Castro, Wanda; Shah, Anjali; Courtney, Ardith; Ortstadt, Jeffrey; Davis, Scott L.; Logan, Diana; Abraham, Thomas; Abraham, Jaspreet; Remington, Gina; Treadaway, Katherine; Graves, Donna; Hart, John; Stuve, Olaf; Lemack, Gary; Greenberg, Benjamin; Frohman, Elliot M.

2011-01-01

259

Multiple-Valued Quantum Logic  

Microsoft Academic Search

This paper introduces the concept of multiple- valued quantum logic, where more than two quantum basis states are introduced, for instance { 0 , 1 , 2 } for ternary quantum logic. Since the binary 2-qubit Einstein-Podolsky-Rosen (EPR) basis states play an important role in quantum logic circuits and superdense coding, their generalization to multiple-valued N-qubit EPR basis states is

Anas Al-Rabadi; Lee Casperson; Marek Perkowski; Xiaoyu Song

2002-01-01

260

The Philosophy of Multiple Comparisons  

Microsoft Academic Search

This paper is based on the 1989 Miller Memorial Lecture at Stanford University. The topic was chosen because of Rupert Miller's long involvement and significant contributions to multiple comparison procedures and theory. Our emphasis will be on the major questions that have received relatively little attention--on what one wants multiple comparisons to do, on why one wants to do that,

John W. Tukey

1991-01-01

261

Teaching for Mastery of Multiplication  

ERIC Educational Resources Information Center

The strategies for learning multiplication concepts are discussed. The strategies involve introduction of the multiplication concepts through problem solutions with linkage between new concepts and prior knowledge, provision of concrete experiences and semi-concrete representations prior to purely symbolic notations, explicit teaching of the rules…

Wallace, Ann H.; Gurganus, Susan P.

2005-01-01

262

Multiple Sclerosis and Vitamin D  

MedlinePLUS

... 2011;77;e99-e100 Neurology Andrew J. Solomon Multiple sclerosis and vitamin D This information is current as ... 2011;77;e99-e100 Neurology Andrew J. Solomon Multiple sclerosis and vitamin D This information is current as ...

263

Multiple Intelligences for Differentiated Learning  

ERIC Educational Resources Information Center

There is an intricate literacy to Gardner's multiple intelligences theory that unlocks key entry points for differentiated learning. Using a well-articulated framework, rich with graphic representations, Williams provides a comprehensive discussion of multiple intelligences. He moves the teacher and students from curiosity, to confidence, to…

Williams, R. Bruce

2007-01-01

264

Multiple testing procedures under confounding  

Microsoft Academic Search

While multiple testing procedures have been the focus of much statistical research, an important facet of the problem is how to deal with possible confounding. Procedures have been developed by authors in genetics and statistics. In this chapter, we relate these proposals. We propose two new multiple testing approaches within this framework. The first combines sensitivity analysis methods with false

Debashis Ghosh

2008-01-01

265

Symptomatic therapy in multiple sclerosis.  

PubMed

Multiple sclerosis is the most common disabling neurological disease of young adults. The ability to impact the quality of life of patients with multiple sclerosis should not only incorporate therapies that are disease modifying, but should also include a course of action for the global multidisciplinary management focused on quality of life and functional capabilities. PMID:21694806

Frohman, Teresa C; Castro, Wanda; Shah, Anjali; Courtney, Ardith; Ortstadt, Jeffrey; Davis, Scott L; Logan, Diana; Abraham, Thomas; Abraham, Jaspreet; Remington, Gina; Treadaway, Katherine; Graves, Donna; Hart, John; Stuve, Olaf; Lemack, Gary; Greenberg, Benjamin; Frohman, Elliot M

2011-03-01

266

Multiple Births, United States 1964.  

National Technical Information Service (NTIS)

In the report statistics are presented for sets of multiple births occurring in the United States in 1964. The report discusses trends in the incidence of multiple births and variations in rates for twin and triplet births by age of mother, number of prev...

R. Heuser

1967-01-01

267

Teaching for Mastery of Multiplication  

ERIC Educational Resources Information Center

|The strategies for learning multiplication concepts are discussed. The strategies involve introduction of the multiplication concepts through problem solutions with linkage between new concepts and prior knowledge, provision of concrete experiences and semi-concrete representations prior to purely symbolic notations, explicit teaching of the…

Wallace, Ann H.; Gurganus, Susan P.

2005-01-01

268

Multiple Watermarking with Side Information  

NASA Astrophysics Data System (ADS)

The idea of side information is introduced into multiple watermarking, and a multiple watermarking model with side information is proposed based on the Slepian-Wolf source encoding theory. In the proposed model, the correlation between the cover work and the multiple watermarks and the correlation among the watermarks themselves are considered and used as side information. The proposed model is used to improve the regular segmented multiple watermarking algorithm, and a novel watermarking algorithm is presented. Experimental results show that the improved algorithm can get a much better validity compared with the regular blind algorithm, and the efficiency of the proposed model is demonstrated. Namely, the proposed model can be used to guide the design of multiple watermarking algorithms effectively.

Xiao, Jun; Wang, Ying

269

Kepler Systems That Show Multiple Transiting Objects  

NASA Astrophysics Data System (ADS)

Exoplanetary systems that have multiple transiting planets provide unique and important insight into the formation, evolution, and dynamics of exoplanetary systems. Kepler has announced the discovery of a confirmed planetary system with multiple transiting planets (Kepler 9, Holman et al. 2010) as well as several candidate planetary systems that show multiple transiting objects (Steffen et al. 2010). Kepler 9 shows deviations from a constant period due to the ongoing dynamical interactions between the confirmed planets. From these transit timing variations (TTV) one can measure the planetary masses from the photometric data alone. The presence of several systems with multiple transiting candidates from the first quarter of data indicate that Kepler should continue to find systems with multiple transiting planets. Such systems will provide important, general information about the histories of planetary systems.

Steffen, Jason H.; Fabrycky, D. C.; Ford, E. B.; Holman, M. J.; Lissauer, J. J.; Ragozzine, D.; Welsh, W. F.; Kepler Science Team

2011-01-01

270

Determinants of on-the-job-barriers in employed persons with multiple sclerosis: The role of disability severity and cognitive indices.  

PubMed

BACKGROUND: Literature has shown that work maintenance is central in order to guarantee participation to persons with disability. Knowledge about potential sources of difficulties and obstacles is then crucial in order to prevent barriers and facilitate work maintenance and career development for persons with disabilities. OBJECTIVE: Studies analyzing on-the-job barriers among employed people with multiple sclerosis (MS) have found evidence for a role of clinical determinants. The aim of this study was to describe in more detail the role of disability severity and of cognitive indices on work barriers. PARTICIPANTS: Thirty-two employed adults with a diagnosis of MS with mild to moderate disability severity were included in the study. They were involved in the descriptive study while attending their planned care in the MS unit. METHODS: Subjects completed neurocognitive tasks, a self-report measure of executive functioning and a face-to-face semi-structured interview exploring their perception of barriers at work. RESULTS: Regression analyses showed a specific role of disability severity on perception of barriers due to physical, cognitive and interpersonal relationships; while cognitive indices appeared to predict barriers ascribed to company policy (cognitive score), accessibility (planning score) or difficulties in cognitive and task related abilities (self-rated executive functioning). CONCLUSION: These findings underline the relevance of objective tasks and self-report questionnaires direct and indirect multi-dimensional assessment of functioning for early intervention planning. An ecological model of career development in adults with disabilities is also supported. PMID:23531588

Carrieri, L; Sgaramella, T M; Bortolon, F; Stenta, G; Fornaro, L; Cracco, A; Perini, F; Soresi, S

2013-03-26

271

Using multiple chemical indicators to characterize and determine the age of groundwater from selected vents of the silver springs group, Central Florida, USA  

USGS Publications Warehouse

The Silver Springs Group, Florida (USA), forms the headwaters of the Silver River and supports a diverse ecosystem. The 30 headwater springs divide into five subgroups based on chemistry. Five selected spring vents were sampled in 2007 to better understand the contaminant sources and groundwater flow system. Elevated nitrate-N concentrations (>0.8mg/L) in the five spring vents likely originate from inorganic (fertilizers) and organic sources, based on nitrogen and oxygen isotope ratios of nitrate. Evidence for denitrification in the Lost River Boil spring includes enriched ??15N and ??18O, excess N2 gas, and low dissolved O2 concentrations (<0.5mg/L). Multiple age-tracer data (SF6, 3H, tritiogenic 3He) for the two uppermost springs (Mammoth East and Mammoth West) indicate a binary mixture dominated by recent recharge water (mean age 6-7 years, and 87-97% young water). Tracer data for the three downstream spring vents (Lost River Boil, Catfish Hotel-1, and Catfish Conventional Hall-1) indicate exponential mixtures with mean ages of 26-35 years. Contamination from non-atmospheric sources of CFCs and SF5CF3 precluded their use as age tracers here. Variations in chemistry were consistent with mean groundwater age, as nitrate-N and dissolved O2 concentrations were higher in younger waters, and the Ca/Mg ratio decreased with increasing mean age. ?? 2010 Springer-Verlag (outside the USA).

Knowles, Jr. , L.; Katz, B. G.; Toth, D. J.

2010-01-01

272

Using multiple chemical indicators to characterize and determine the age of groundwater from selected vents of the Silver Springs Group, central Florida, USA  

NASA Astrophysics Data System (ADS)

The Silver Springs Group, Florida (USA), forms the headwaters of the Silver River and supports a diverse ecosystem. The 30 headwater springs divide into five subgroups based on chemistry. Five selected spring vents were sampled in 2007 to better understand the contaminant sources and groundwater flow system. Elevated nitrate-N concentrations (>0.8 mg/L) in the five spring vents likely originate from inorganic (fertilizers) and organic sources, based on nitrogen and oxygen isotope ratios of nitrate. Evidence for denitrification in the Lost River Boil spring includes enriched ?15N and ?18O, excess N2 gas, and low dissolved O2 concentrations (<0.5 mg/L). Multiple age-tracer data (SF6, 3H, tritiogenic 3He) for the two uppermost springs (Mammoth East and Mammoth West) indicate a binary mixture dominated by recent recharge water (mean age 6-7 years, and 87-97% young water). Tracer data for the three downstream spring vents (Lost River Boil, Catfish Hotel-1, and Catfish Conventional Hall-1) indicate exponential mixtures with mean ages of 26-35 years. Contamination from non-atmospheric sources of CFCs and SF5CF3 precluded their use as age tracers here. Variations in chemistry were consistent with mean groundwater age, as nitrate-N and dissolved O2 concentrations were higher in younger waters, and the Ca/Mg ratio decreased with increasing mean age.

Knowles, Leel; Katz, Brian G.; Toth, David J.

2010-12-01

273

Complementary identification of multiple flux distributions and multiple metabolic pathways.  

PubMed

Cell robustness and complexity have been recognized as unique features of biological systems. Such robustness and complexity of metabolic-reaction systems can be explored by discovering, or identifying, the multiple flux distributions (MFD) and redundant pathways that lead to a given external state; however, this is exceedingly cumbersome to accomplish. It is, therefore, highly desirable to establish an effective computational method for their identification, which, in turn, gives rise to a novel insight into the cellular function. An effective approach is proposed for complementarily identifying MFD in metabolic flux analysis and multiple metabolic pathways (MMP) in structural pathway analysis. This approach judiciously integrates flux balance analysis (FBA) based on linear programming and the graph-theoretic method for determining reaction pathways. A single metabolic pathway, with the concomitant flux distribution and the overall reaction manifesting itself as the desired phenotype under some environmental conditions, is determined by FBA from the initial candidate sequence of metabolic reactions. Subsequently, the graph-theoretic method recovers all feasible MMP and the corresponding MFD. The approach's efficacy is demonstrated by applying it to the in silico Escherichia coli model under various culture conditions. The resultant MMP and MFD attaining a unique external state reveal the surprising adaptability and robustness of the intricate cellular network as a key to cell survival against environmental or genetic changes. These results indicate that the proposed approach would be useful in facilitating drug discovery. PMID:15885617

Lee, Dong-Yup; Fan, L T; Park, Sunwon; Lee, Sang Yup; Shafie, Shahram; Bertók, Botond; Friedler, Ferenc

2005-05-01

274

Duration Judgments Over Multiple Elements  

PubMed Central

We investigated the limits of the number of events observers can simultaneously time. For single targets occurring in one of eight positions sensitivity to duration was improved for spatially pre-cued items as compared to post-cued items indicating that exogenous driven attention can improve duration discrimination. Sensitivity to duration for pre-cued items was also marginally better for single items as compared to eight items indicating that even after the allocation of focal attention, distractor items can interfere with the encoding of duration. For an eight item array discrimination was worse for post-cued locations as compared to pre-cued locations indicating both that attention can improve duration discrimination performance and that it was not possible to access a perfect memory trace of the duration of eight elements. The interference from the distractors in the pre-cued eight item array may reflect some mandatory averaging of target and distractor events. To further explore duration averaging we asked subjects to explicitly compare average durations of multiple item arrays against a single item standard duration. Duration discrimination thresholds were significantly lower for single elements as compared to multiple elements, showing that averaging, either automatically or intentionally, impairs duration discrimination. There was no set size effect. Performance was the same for averages of two and eight items, but performance with even an average of two items was worse than for one item. This was also true for sequential presentation indicating poor performance was not due to limits on the division of attention across items. Rather performance appears to be limited by an inability to remember or aggregate duration information from two or more items. Although it is possible to manipulate perceived duration locally, there appears to be no perceptual mechanisms for aggregating local durations across space.

Ayhan, Inci; Revina, Yulia; Bruno, Aurelio; Johnston, Alan

2012-01-01

275

Multiple-input-multiple-output measurements and modeling in Manhattan  

Microsoft Academic Search

Narrowband multiple-input-multiple-output (MIMO) measurements using 16 transmitters and 16 receivers at 2.11 GHz were carried out in Manhattan. High capacities were found for full, as well as smaller array configurations, all within 80% of the fully scattering channel capacity. Correlation model parameters are derived from data. Spatial MIMO channel capacity statistics are found to be well represented by the separate

Dmitry Chizhik; Jonathan Ling; Peter W. Wolniansky; Reinaldo A. Valenzuela; Nelson Costa; Kris Huber

2003-01-01

276

Proton interactions with high multiplicity  

SciTech Connect

Project Thermalization is aimed to study the proton-proton interaction with high multiplicity of secondary particles. The region of high multiplicity is especially actual at present. We expect the manifestation of the secondary particle collective behavior at this region. The experimentally measured topological cross section was corrected for apparatus acceptance and detection efficiency. These data are in good agreement with gluon dominance model. The comparison with other models is also done and shows no essential deviations. There is evidence that Bose-Einstein condensation can formed at high total multiplicity region.

Kokoulina, E. S., E-mail: kokoulin@sunse.jinr.ru; Nikitin, V. A.; Petukhov, Y. P. [LHEP, JINR (Russian Federation); Kutov, A. Ya. [Department of Mathematics Komi SC UrD RAS (Russian Federation)

2012-06-15

277

Multiple-wavelength plasmonic nanoantennas.  

PubMed

We propose a type of photonic-plasmonic antennas capable of focusing light into subwavelength focal point(s) at several wavelengths, which are formed by embedding conventional dimer gap or bow-tie nanoantennas into multiple-periodic gratings. Fano-type coupling between localized surface plasmon resonances of dimer antennas and photonic modes in the gratings adds new functionalities, including multiple-wavelength operation and controllable enhancement of the field intensity in the focal point. Multiple-wavelength operation of nanoantennas provides tremendous opportunities for broadband single-molecule fluorescence and Raman sensing, emission enhancement, and near-field imaging. PMID:20160810

Boriskina, Svetlana V; Dal Negro, Luca

2010-02-15

278

Areas in a Multiplication Table  

NSDL National Science Digital Library

This interactive Wolfram Demonstration helps students visualize the relationship between multiplication and the area of a rectangle. On a 10x10 multiplication table, with 1 in the lower left and 100 in the upper right, users adjust the size of a rectangle by dragging a vertex or sliders, or by choosing a product from a pulldown list. The resulting rectangle highlights the width, height and area (factors and product) as well as other equivalent areas (products) on the board, illustrating commutativity and multiple factor pairs. Wolfram CDF Player, a free download, is required to view this resource.

Schreiber, Michael

2012-01-01

279

Using d15 N in Fish Larvae as an Indicator of Watershed Sources of Anthropogenic Nitrogen: Response at Multiple Spatial Scales  

EPA Science Inventory

The nitrogen stable isotope, 15N, is an effective tool to track anthropogenic N sources to aquatic ecosystems. It may be difficult to identify potential N sources, however, where 15N responds similarly to multiple, concurrent activities in the watershed that cause higher nutrient...

280

Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects  

Microsoft Academic Search

Anabolic androgenic steroids (AAS) are doping agents that are mostly used for improvement of strength and muscle hypertrophy. In some sports, athletes reported that the intake of AAS is associated with a better recovery, a higher training load capacity and therefore an increase in physical and mental performances. The purpose of this study was to evaluate, the effect of multiple

Norbert Baume; Yorck Olaf Schumacher; Pierre-Edouard Sottas; Carlo Bagutti; Michel Cauderay; Patrice Mangin; Martial Saugy

2006-01-01

281

In silico modeling indicates the development of HIV1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy  

Microsoft Academic Search

BACKGROUND: Gene therapy has the potential to counter problems that still hamper standard HIV antiretroviral therapy, such as toxicity, patient adherence and the development of resistance. RNA interference can suppress HIV replication as a gene therapeutic via expressed short hairpin RNAs (shRNAs). It is now clear that multiple shRNAs will likely be required to suppress infection and prevent the emergence

Tanya Lynn Applegate; Donald John Birkett; Glen John Mcintyre; Angel Belisario Jaramillo; Geoff Symonds; John Michael Murray

2010-01-01

282

Binary and Multiple Systems Binary and Multiple Systems  

NASA Astrophysics Data System (ADS)

Recent observational advances have led to the realization that binary or multiple systems are common in small body populations from the near-Earth objects through the main belt and out to the Kuiper Belt. Understanding the formation processes of such systems is critical to understanding the collisional and dynamical evolution of small body systems, including even dwarf planets. Binary and multiple systems provide a means of determining critical physical properties (masses, densities, and rotations) with greater ease and higher precision than is available for single objects. Binaries and multiples provide a natural laboratory for dynamical investigations and may exhibit unique geologic processes such as mass transfer or even accretion disks. Missions to many classes of planetary bodies - asteroids, Trojans, TNOs, dwarf planets - can offer enhanced science return if they target binary or multiple systems. Significant resources should be dedicated to investigations using large aperture facilities with advanced instrumentation. Fundamental questions remain to be answered: does the prevalence of binary and multiple systems differ between populations (e.g., NEOs versus main belt, Trojans versus TNOs)? Are the fundamental physical characteristics of binaries, which reflect their formation mechanisms and later evolution, different in these populations (their spin periods versus mutual orbit periods, their orbital separations versus sizes)? Are binary and multiple systems more likely to be found in asteroid families? Are binary systems more likely to contain rubble pile objects? Do binary systems evolve into single bodies, or vice versa, and how might that happen?

Cheng, A. F.; Rivkin, A.; Michel, P.; Lisse, C. M.; Walsh, K.; Noll, K. S.; Ragozzine, D.; Benner, L.

2009-12-01

283

Multiple Indicator Cluster Survey 2003 in Afghanistan: Outdated Sampling Frame and the Effect of Sampling Weights on Estimates of Maternal and Child Health Coverage  

PubMed Central

Due to an urgent need for information on the coverage of health service for women and children after the fall of Taliban regime in Afghanistan, a multiple indicator cluster survey (MICS) was conducted in 2003 using the outdated 1979 census as the sampling frame. When 2004 pre-census data became available, population-sampling weights were generated based on the survey-sampling scheme. Using these weights, the population estimates for seven maternal and child healthcare-coverage indicators were generated and compared with the unweighted MICS 2003 estimates. The use of sample weights provided unbiased estimates of population parameters. Results of the comparison of weighted and unweighted estimates showed some wide differences for individual provincial estimates and confidence intervals. However, the mean, median and absolute mean of the differences between weighted and unweighted estimates and their confidence intervals were close to zero for all indicators at the national level. Ranking of the five highest and the five lowest provinces on weighted and unweighted estimates also yielded similar results. The general consistency of results suggests that outdated sampling frames can be appropriate for use in similar situations to obtain initial estimates from household surveys to guide policy and programming directions. However, the power to detect change from these estimates is lower than originally planned, requiring a greater tolerance for error when the data are used as a baseline for evaluation. The generalizability of using outdated sampling frames in similar settings is qualified by the specific characteristics of the MICS 2003—low replacement rate of clusters and zero probability of inclusion of clusters created after the 1979 census.

Shuaib, Muhammad; Becker, Stan; Rahman, Md. Mokhlesur; Peters, David H.

2011-01-01

284

MULTIPLE ECH LAUNCHER CONTROL SYSTEM  

SciTech Connect

OAK-B135 The addition of new, high power gyrotrons to the heating and current drive arsenal at DIII-D, required a system upgrade for control of fully steerable ECH Launchers. Each launcher contains two pointing mirrors with two degrees of mechanical freedom. The two flavors of motion are called facet and tilt. Therefore up to four channels of motion per launcher need to be controlled. The system utilizes absolute encoders to indicate mirror position and therefore direction of the microwave beam. The launcher movement is primarily controlled by PLC, but future iterations of design, may require this control to be accomplished by a CPU on fast bus such as Compact PCI. This will be necessary to accomplish real time position control. Safety of equipment and personnel is of primary importance when controlling a system of moving parts. Therefore multiple interlocks and fault status enunciators have been implemented. This paper addresses the design of a Multiple ECH Launcher Control System, and characterizes the flexibility needed to upgrade to a real time position control system in the future.

GREEN,M.T; PONCE,D; GRUNLOH,H.J; ELLIS,R.A; GROSNICKLE,W.H; HUMPHREY,R.L

2003-10-01

285

[Ocular motor disorders in multiple sclerosis].  

PubMed

Multiple sclerosis is the most common disabling neurological disease in young people. Many neuro-ophthalmological manifestations can occur during the course of the illness, and optic neuritis is both the most frequent and the best known. However, some ocular motility disorders can also occur, but since there may be no symptoms, they often remain underdiagnosed. These eye movement disorders are mostly related to brain-stem and cerebellum lesions. They can be acute, indicating a spatial dissemination of the demyelinating disease, and consequently may indicate the need for systemic treatment of multiple sclerosis. More often, they evolve slowly, progressing with the multiple sclerosis. In this case, they could provide a clue to the prognosis of the disease. In this survey, we discuss the two major symptoms of ocular motor disorders likely to occur during multiple sclerosis: oscillopsia and diplopia. PMID:18971858

Rougier, M-B; Tilikete, C

2008-09-01

286

Coordination of Multiple Robotic Manipulators.  

National Technical Information Service (NTIS)

In this thesis, the problem of the coordination of multiple robots is investigated at length. Included in the discussion are the position control, path planning, and collision avoidance strategies involved in the control of two robots mutually holding an ...

R. F. Young

1987-01-01

287

Multiple Regression and Its Discontents  

ERIC Educational Resources Information Center

Multiple regression is part of a larger statistical strategy originated by Gauss. The authors raise questions about the theory and suggest some changes that would make room for Mandelbrot and Serendipity.

Snell, Joel C.; Marsh, Mitchell

2012-01-01

288

Laryngeal Involvement of Multiple Myeloma  

PubMed Central

The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myeloma, also noted in the literature as “metastatic” multiple myeloma, presenting as a de novo laryngeal mass is extremely rare with few reported cases. Laryngeal involvement of extramedullary tumors is reported to be between 6% and 18% with the epiglottis, glottis, false vocal folds, aryepiglottic folds, and subglottis involved in decreasing the order of frequency. We present the case of a 58-year-old male with a history of IgA smoldering myeloma who presented to a tertiary care laryngological practice with a two-month history of dysphonia, which was found to be laryngeal involvement of multiple myeloma. We review the classification of and differentiation between different plasma cell neoplasms, disease workups, pathologic findings, and treatment options.

Grobman, Ariel B.; Vivero, Richard J.; Campuzano-Zuluaga, German; Ganjei-Azar, Parvin; Rosow, David E.

2012-01-01

289

The Importance of Multiple Choice.  

National Technical Information Service (NTIS)

A level of organization of inferences in which competing plausible alternatives can be compared, and all but one actively rejected, is a very important aspect of any comprehension model. Multiple choice inference structures help the model stay tuned to th...

C. Rieger

1978-01-01

290

Alternatives for Teaching Multiplication Facts.  

ERIC Educational Resources Information Center

A learning disabled student was drilled on multiplication facts, with records of his performance used to help him reach mastery. A sequence in which the 0 facts, 1 facts, etc., are taught is used. (MNS)

Lessen, Elliott I.; Cumblad, Carla L.

1984-01-01

291

The multiple birth epidemic: revisited.  

PubMed

The modern era of infertility treatment was heralded over half a century ago with the introduction of new hormonal drugs that could effectively induce ovarian ovulation. However, it was quickly recognized that the birth of these new "miracle drugs" was associated with a remarkable increase in the incidence of high-order multiple births. Despite the fantastic improvement in our ability to monitor ovarian response during ovulation induction, and our power to control the number of embryos introduced into the womb through IVF, multiple births remain a leading cause of long-term child morbidity among infertility patients. Efforts to prevent what was coined in the 1960s as the "multiple birth epidemic" remain an urgent concern. A new body of research clearly points at our capacity to reduce the risk of multiple births and their associated long term morbidity without diminishing current high success rates of infertility treatment. PMID:23904695

Avraham, Sarit; Seidman, Daniel S

2012-08-01

292

Multiple myeloma. Houses and spouses  

SciTech Connect

Two families in which successive spouses who lived in the same house developed multiple myeloma are reported. In the first instance, a man whose first wife died of multiple myeloma remarried, and his second wife also developed myeloma. In the second family, a woman's first husband died of multiple myeloma and her second husband did too. Radiation studies of the houses and yards showed no increased radioactivity. No evidence was found for excessive exposure to chemicals or other environmental agents, for contact with other patients having similar malignancies, or for exposure to viruses or other transmissible factors. The significance of the occurrence of multiple myeloma in subsequent spouses is unknown. It is hoped that this report will stimulate research for other instances and lead to careful epidemiologic, radiologic, and virologic studies.

Kyle, R.A.; Greipp, P.R.

1983-02-15

293

Coloring Multiples in Pascal's Triangle  

NSDL National Science Digital Library

This Java applet activity allows the learner to visually identify number patterns in Pascal's triangle as they color multiples of a given number. The user can also click on an auto-color button that will automatically color the multiples of the given number. The number of rows of Pascal's triangle can be increased or decreased. There are separate tabs to access information for the learner, the instructor and to seek help.

2004-01-01

294

Depression associated with multiple sclerosis  

Microsoft Academic Search

Background: While it is recognised that patients with multiple sclerosis have a high lifetime risk for major depression, less is known about sub-syndromal presentations of affective instability, i.e., irritability, sadness and tearfulness and how these symptoms of emotional dyscontrol may affect a subject’s overall degree of psychological distress. Methods: A consecutive sample of 100 out-patients with clinically definite multiple sclerosis

Anthony Feinstein; Karen Feinstein

2001-01-01

295

Multiple oncocytomas and renal carcinoma  

SciTech Connect

Renal oncocytoma, although rare, is being diagnosed more frequently, and criteria to differentiate it from other tumors have been described. Multiple oncocytomas have been reported, but an association between multiple oncocytomas and renal carcinoma in the same kidney has not been described. The authors report a case with two oncocytomas and a renal carcinoma in the right kidney as well as a right adrenal adenoma.

Velasquez, G.; Glass, T.A.; D'Souza, V.J.; Formanek, A.G.

1984-01-01

296

Gender issues and multiple sclerosis  

Microsoft Academic Search

Gender-related issues in multiple sclerosis include the important and widely accepted clinical observations that men are less\\u000a susceptible to the disease than women and also that disease activity in multiple sclerosis is decreased during late pregnancy.\\u000a This article reviews mechanisms underlying each of these clinical observations and discusses the role of sex hormones in each.\\u000a Specifically, the protective role of

Rhonda R. Voskuhl

2002-01-01

297

Let's Practice Multiplication and Division!  

NSDL National Science Digital Library

Use the games below to improve your multiplication and division skills. Today, we are going to play some fun games that help us get better at multiplication and division. Follow the directions below: 1. Choose one of the following games. If you are a boy, you may wish to play with the catapult in Flight of the Knight. If you are a girl, you could ...

Aycock, Miss

2009-04-15

298

Multiple objective ant colony optimisation  

Microsoft Academic Search

Multiple Objective Optimisation is a fast growing area of research, and consequently several Ant Colony Optimisation approaches\\u000a have been proposed for a variety of these problems. In this paper, a taxonomy for Multiple Objective Ant Colony Optimisation\\u000a algorithms is proposed and many existing approaches are reviewed and described using the taxonomy. The taxonomy offers guidelines\\u000a for the development and use

Daniel Angus; Clinton Woodward

2009-01-01

299

On certain multiplicity one theorems  

Microsoft Academic Search

We prove several multiplicity one theorems in this paper. Fork a local field not of characteristic two, andV a symplectic space overk, any irreducible admissible representation of the symplectic similitude group GSp(V) decomposes with multiplicity one when restricted to the symplectic group Sp(V). We prove the analogous result for GO(V) and O(V), whereV is an orthogonal space overk. Whenk is

Jeffrey D. Adler; Dipendra Prasad

2006-01-01

300

The INEL beryllium multiplication experiment  

SciTech Connect

The experiment to measure the multiplication of 14-MeV neutrons in bulk beryllium has been completed. The experiment consists of determining the ratio of {sup 56}Mn activities induced in a large manganese bath by a central 14-MeV neutron source, with and without a beryllium sample surrounding the source. In the manganese bath method a neutron source is placed at the center of a totally-absorbing aqueous solution of MnSo{sub 4}. The capture of neutrons by Mn produces a {sup 56}Mn activity proportional to the emission rate of the source. As applied to the measurement of the multiplication of 14- MeV neutrons in bulk beryllium, the neutron source is a tritium target placed at the end of the drift tube of a small deuteron accelerator. Surrounding the source is a sample chamber. When the sample chamber is empty, the neutrons go directly to the surrounding MnSO{sub 4} solution, and produce a {sup 56}Mn activity proportional to the neutron emission rate. When the chamber contains a beryllium sample, the neutrons first enter the beryllium and multiply through the (n,2n) process. Neutrons escaping from the beryllium enter the bath and produce a {sup 56}Mn activity proportional to the neutron emission rate multiplied by the effective value of the multiplication in bulk beryllium. The ratio of the activities with and without the sample present is proportional to the multiplication value. Detailed calculations of the multiplication and all the systematic effects were made with the Monte Carlo program MCNP, utilizing both the Young and Stewart and the ENDF/B-VI evaluations for beryllium. Both data sets produce multiplication values that are in excellent agreement with the measurements for both raw and corrected values of the multiplication. We conclude that there is not real discrepancy between experimental and calculated values for the multiplication of neutrons in bulk beryllium. 12 figs., 11 tabs., 18 refs.

Smith, J.R.; King, J.J.

1991-03-01

301

Studies of porcine circovirus type 2, porcine boca-like virus and torque teno virus indicate the presence of multiple viral infections in postweaning multisystemic wasting syndrome pigs.  

PubMed

In a previous study, using random amplification and large-scale sequencing technology, we identified a novel porcine parvovirus belonging to the genus Bocavirus in the background of porcine circovirus type 2 (PCV-2) in Swedish pigs with postweaning multisystemic wasting syndrome (PMWS). In addition to bocavirus we demonstrated the presence of torque teno virus (TTV) genogroups 1 and 2 in these cases of PMWS, indicating the simultaneous presence of several viruses in this disease complex. In the present study, 34 PMWS-affected animals and 24 pigs without PMWS were screened by PCR for the presence of PCV-2, TTV-1, TTV-2 and porcine boca-like virus (Pbo-likeV). The studies revealed the following infection rates in the PMWS-affected pigs: PCV-2 100%, TTV-1 77%, TTV-2 94% and Pbo-likeV 88%. In comparison, the pigs without PMWS had the following rates: PCV-2 80%, TTV-1 79%, TTV-2 83% and Pbo-likeV 46%. The sequence identity between the different Swedish Pbo-likeV sequences ranged between 98% and 100%. By checking co-infection, it was found that 71% of the PMWS-affected pigs harbor simultaneously all these viruses. As a contrast, in the group without PMWS only 33% of the animals were positive simultaneously for these viruses. These observations indicate a multiple viral infection in PMWS-affected pigs. It has to be studied further if the clinical manifestation of PMWS might be due to synergistic effects of different viruses acting together. PMID:20542066

Blomström, Anne-Lie; Belák, Sándor; Fossum, Caroline; Fuxler, Lisbeth; Wallgren, Per; Berg, Mikael

2010-06-11

302

Progress in Multiple Sclerosis Genetics  

PubMed Central

A genetic component in the susceptibility to multiple sclerosis (MS) has long been known, and the first and major genetic risk factor, the HLA region, was identified in the 1970’s. However, only with the advent of genome-wide association studies in the past five years did the list of risk factors for MS grow from 1 to over 50. In this review, we summarize the search for MS risk genes and the latest results. Comparison with data from other autoimmune and neurological diseases and from animal models indicates parallels and differences between diseases. We discuss how these translate into an improved understanding of disease mechanisms, and address current challenges such as genotype-phenotype correlations, functional mechanisms of risk variants and the missing heritability.

Goris, An; Pauwels, Ine; Dubois, Benedicte

2012-01-01

303

Cognitive Dysfunction in Multiple Sclerosis  

PubMed Central

In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes particularly important. In this review the authors address: the cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing, and visual–spatial abilities); the pathophysiological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance; the most used tests and batteries for neuropsychological assessment; therapeutic strategies to improve cognitive abilities.

Guimaraes, Joana; Sa, Maria Jose

2012-01-01

304

Combination therapy in multiple sclerosis.  

PubMed

Multiple sclerosis (MS) is an autoimmune disease of the CNS. It is the most common non-traumatic cause of neurological disability among young adults in western Europe and North America. Existing MS therapies are partly effective in halting ongoing inflammatory tissue damage and clinical progression. MS pathogenesis is complex and probably heterogeneous among patients, suggesting that combination therapy strategies that target a range of disease mechanisms might be more effective than medications used as monotherapy. Potential regimens include the combination of interferons and glatiramer acetate with each other or with approved second-line drugs such as natalizumab and mitoxantrone. Disease-modifying therapies have also been used in combination with drugs approved for other indications, such as corticosteroids, methotrexate, azathioprine, and cyclophosphamide. Many preliminary studies have provided favourable results for various combination regimens. However, several subsequent large, randomised, controlled trials have had negative or conflicting results. Therefore, the usefulness of combination therapy in MS remains uncertain. PMID:20170843

Conway, Devon; Cohen, Jeffrey A

2010-03-01

305

Multiple Prediction Studies.  

National Technical Information Service (NTIS)

The report indicates the general areas of investigation in a program of research in the prediction of personal adjustment, conducted over a period of seventeen years. The publications resulting from the research and listed in the bibliography include thir...

P. Horst

1970-01-01

306

A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis  

Microsoft Academic Search

Background:Past sun exposure and vitamin D3 supplementation have been associated with a reduced risk of multiple sclerosis (MS). There are no previous longitudinal studies of vitamin D in MS.Objectives:To compare regulation of vitamin D and calcium homeostasis between patients with MS and healthy controls. To study the correlation of parameters of vitamin D metabolism with MS activity.Methods:We measured 25-hydroxyvitamin D

M Soilu-Hänninen; M Laaksonen; I Laitinen; J-P Erälinna; E-M Lilius; I Mononen

2008-01-01

307

Multiplication of Fractions through Paper Folding.  

ERIC Educational Resources Information Center

Presents an instructional approach that utilizes paper-folding activities to help students understand the concept of fractions. Utilizes an area model of multiplication to extend the concept of multiplication of whole numbers to multiplication of fractions. (MDH)

Sinicrope, Rose; Mick, Harold W.

1992-01-01

308

The MARVEL assembly for neutron multiplication.  

PubMed

A new multiplying test assembly is under development at Idaho National Laboratory to support research, validation, evaluation, and learning. The item is comprised of three stacked, highly-enriched uranium (HEU) cylinders, each 11.4cm in diameter and having a combined height of up to 11.7cm. The combined mass of all three cylinders is 20.3kg of HEU. Calculations for the bare configuration of the assembly indicate a multiplication level of >3.5 (keff=0.72). Reflected configurations of the assembly, using either polyethylene or tungsten, are possible and have the capability of raising the assembly's multiplication level to greater than 10. This paper describes simulations performed to assess the assembly's multiplication level under different conditions and describes the resources available at INL to support the use of these materials. We also describe some preliminary calculations and test activities using the assembly to study neutron multiplication. PMID:23827507

Chichester, David L; Kinlaw, Mathew T

2013-06-10

309

Combining multiple altimeter missions  

NASA Astrophysics Data System (ADS)

Viewing altimeter data only at the points where separate altimeter missions' ground tracks cross provides a method to observe long time period sea surface height (SSH) variations and avoids many of the problems inherent in combining separate altimeter data sets through an independently determined geoid. TOPEX/POSEIDON (T/P) data over the time period from January 1, 1993, to December 31, 1995, form a mean SSH that is used as a reference by other altimeter data sets. A least squares analysis of the mean T/P SSH determines the portion of the Geographically Correlated Orbit Error (GCOE) that may be observed through crossover differences and removes this portion of the GCOE. The analysis removes errors of 0.86 cm RMS at 1 cycle per orbit revolution (cpr) and indicates negligible errors at higher frequencies. After the GCOE removal, the accuracy of the T/P reference mean is better than 1 cm RMS as measured by crossover differences. The GCOE contained in the Geosat-Exact Repeat Mission (ERM) and ERS 1 data with orbit solutions using the Joint Gravity Model (JGM) 3 is evaluated through an adjustment to the T/P reference mean surface. The Geosat-ERM data indicate a bias of about 28 cm averaged over the globe, and the ERS 1 bias is 44 cm. The T/P data used here is not corrected for the oscillator drift correction error so that the actual bias is less by about 13 cm. Both the Geosat-ERM and ERS 1 GCOE are mainly 1 cpr. GCOE estimates at frequencies above 1 cpr indicate little actual orbit error but are more correlated to instrument correction errors (particularly water vapor). Simultaneous T/P and ERS 1 SSH anomalies to the T/P mean indicate good correlation.

Jacobs, G. A.; Mitchell, J. L.

1997-10-01

310

Multiple pilomatricomas in Kabuki syndrome.  

PubMed

Pilomatricoma is a benign tumor of the hair matrix cell that presents predominantly in childhood. Although pilomatricoma occurs spontaneously, multiple pilomatricomas have been described in association with several inherited syndromes. We report on a 28-year-old man with Kabuki syndrome with three pilomatricomas in his head and thigh. Although several reports describe multiple pilomatricomas associated with Turner syndrome, there are no reports of multiple pilomatricomas combined with Kabuki syndrome. Ectodermal abnormalities such as hair abnormality and hirsutism are symptoms of Kabuki syndrome, and pilomatricomas are frequently associated with the mutations of beta-catenin in hair follicle development. The predisposition of pilomatricomas may be not merely a coincidental finding, but an added association with Kabuki syndrome. PMID:22304445

Hamahata, Atsumori; Kamei, Wataru; Ishikawa, Masashi; Konoeda, Hisato; Yamaki, Takashi; Sakurai, Hiroyuki

2012-02-03

311

Multiple Myeloma Cancer Stem Cells  

PubMed Central

Multiple myeloma is characterized by the clonal expansion of neoplastic plasma cells within the bone marrow, elevated serum immunoglobulin, and osteolytic bone disease. The disease is highly responsive to a wide variety of anticancer treatments including conventional cytotoxic chemotherapy, corticosteroids, radiation therapy, and a growing number of agents with novel mechanisms of action. However, few if any patients are cured with these modalities and relapse remains a critical issue. A better understanding of clonogenic multiple myleoma cells is essential to ultimately improving long-term outcomes, but the nature of the cells responsible for myeloma regrowth and disease relapse is unclear. We review evidence that functional heterogeneity exists in multiple myeloma and discuss potential strategies and clinical implications of the stem-cell model of cancer in this disease.

Huff, Carol Ann; Matsui, William

2008-01-01

312

Multiple Myeloma of the Orbit  

PubMed Central

The authors report a case of a 62-year-old female with history of multiple myeloma who presents with complains of swelling and pain in her right eye. On examination, it was found that she has proptosis, chemosis, and diplopia along with decreased vision. Initial workup and treatment did not yield significant results, eventually she was found to have myelomatous changes in her right orbit on MRI and was diagnosed with multiple myeloma of the orbit which resolved solely with radiation. This case tends to highlight the importance of considering myeloma of the orbit as a very important and early differential diagnosis in a patient with a history of multiple myeloma presenting with a swollen and painful eye.

Hassan, Mona; Alirhayim, Zaid; Sroujieh, Laila; Hassan, Syed

2012-01-01

313

Multiple smart weapons employment mechanism  

SciTech Connect

A digital communications armament network adaptor is described for carrying multiple smart weapons on a single wing pylon station of an aircraft, comprising: an aircraft having a weapons controller configured in compliance with MIL-STD 1553; multiple wing-mounted pylons on said aircraft, each providing a weapons station with communications and ejection and release mechanisms electrically connected to said controller for the airborne launch of smart weapons; a multiple ejector rack affixed to at least one pylon, said rack holding a plurality of smart weapons; and an electronic digital network connected between the controller and said rack-mounted smart weapons, said network located in said rack and including circuitry which receives coded digital communications from said controller and selectively rebroadcasts said communications to one of said smart weapons on said rack designated by said coded communications, thereby controlling all required functions of said designated smart weapon.

McGlynn, M.P.; Meiklejohn, W.D.

1993-07-20

314

Multiple sclerosis and herpesvirus interaction.  

PubMed

Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is that they have periods of latency and exacerbations within their biological sanctuary, the central nervous system. The Epstein-Barr, cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 viruses are the members that are most studied as being possible triggers of multiple sclerosis. According to evidence in the literature, the herpesvirus family is strongly involved in the pathogenesis of this disease, but it is unlikely that they are the only component responsible for its development. There are probably multiple triggers and more studies are necessary to investigate and define these interactions. PMID:24141514

Olival, Guilherme Sciascia do; Lima, Bruna Mendonça; Sumita, Laura M; Serafim, Vitor; Fink, Maria Cristina; Nali, Luis Henrique; Romano, Camila Malta; Thomaz, Rodrigo Barbosa; Cavenaghi, Vitor Breseghello; Tilbery, Charles Peter; Penalva-de-Oliveira, Augusto Cesar

2013-09-01

315

Multiple meteoroid impact in Antarctica  

NASA Astrophysics Data System (ADS)

In the late 1950's, geophysical field parties undertaking gravity surveys across Antarctica observed over a large area of Wilkes Land (> 240km across) an exceptionally pronounced negative free air anomaly ((to -158.3 mgal). This area was later interpreted as a possible meteor impact site because the gravity profiles were similar to those of known impact sites (apparent rim structures, circular basins, central peaks or rings), they possessed appropriate aspect ratios (e.g., crater diameter vs crater depth), anomalously steep negative free air gravity anomaly gradients (to 4.71 mgal/km) were characteristic of impact craters and uncharacteristic of solely mantle-related or geologic crustal variations, etc. The condition of the ice covering the anomaly (heavily crevassed), the apparent lack of isostatic compensation with surrounding environs, etc suggested the impact was geologically recent and that perhaps a tektite strewn field was associated with it. The distance from the postulated impact to the Australian strewn field was appropriate as are the ages of the tektites there. This early work has been augmented with the detection of a dominant cluster of negative free air gravity anomalies crossing the continental-oceanic boundary, and the East and West Antarctic structural boundary (i.e., Transantarctic Mountains). These anomalies are coincident with complex subglacial craterform topographic features inferred from radiosounding (to -500m below MSL). The major interior positive free air gravity anomalies are associated with subglacial topographic highs. The elliptical distribution of the negative gravity anomalies resemble known multiple impact distributions (scatter ellipses with the larger anomalies forward and the lesser ones aft). This more recent information favors expanding the original proposal to that of a multiple meteoroid impact. The multiple impact hypotheses would explain aeromagnetic surveys revealing ring-shaped structures in the subglacial rock surface much like those of known impact structures (the magnetic anomalies are unusual in magnitude themselves: amplitudes to 3600nT for sensors at 3.5 km elevation). Deviations from this topography can be attributed to glacial scour. Certainly glacial surging should accompany such an impact. The distribution of the apparent impact structures extends beyond the original discovery and on the basis of negative free air anomalies, into the Wilkes Subglacial Basin to the south, athwart the Transantarctic Mountains and into the Ross Embayment to the east. No multiple impact sites of comparable size on Earth have been reported. The above suggestions have been augmented by recent work on cores taken from the Ross Sea which has revealed the presence of material of high magnetic susceptibility often taken as an indicator of meteor impact and tektites. The age of this material is placed in the Late Pliocene. The oldest ages reported for meteorites collected from the Antarctic Blue Ice is ca. 700,000y.

Weihoupt, J. W.; Rice, A.; van der Hoeven, F.

2006-12-01

316

Refine results for multiple sclerosis: Multiple Sclerosis Study  

Center for Drug Evaluation (CDER)

Text Version... The' National MS Society exists to make sure it doesn't. http://ww.google.com/ search ?h1=en&q=multiple+sclerosis 8/19/2008 Page 3. ... More results from www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation

317

Decisions and the evolution of memory: Multiple systems, multiple functions  

Microsoft Academic Search

Memory evolved to supply useful, timely information to the organism's decision-making systems. Therefore, decision rules, multiple memory systems, and the search engines that link them should have coevolved to mesh in a coadapted, functionally interlocking way. This adaptationist perspective sug- gested the scope hypothesis: When a generalization is retrieved from semantic memory, episodic memories that are inconsistent with it should

Stanley B. Klein; Leda Cosmides; John Tooby; Sarah Chance

2002-01-01

318

Decisions and the Evolution of Memory: Multiple Systems, Multiple Functions  

Microsoft Academic Search

Memory evolved to supply useful, timely information to the organism's decision-making systems. Therefore, decision rules, multiple memory systems, and the search engines that link them should have coevolved to mesh in a coadapted, functionally interlocking way. This adaptationist perspective suggested the scope hypothesis: When a generalization is retrieved from semantic memory, episodic memories that are inconsistent with it should be

Stanley B. Klein; Leda Cosmides; John Tooby; Sarah Chance

2002-01-01

319

Complementary identification of multiple flux distributions and multiple metabolic pathways  

Microsoft Academic Search

Cell robustness and complexity have been recognized as unique features of biological systems. Such robustness and complexity of metabolic-reaction systems can be explored by discovering, or identifying, the multiple flux distributions (MFD) and redundant pathways that lead to a given external state; however, this is exceedingly cumbersome to accomplish. It is, therefore, highly desirable to establish an effective computational method

Dong-Yup Lee; L. T. Fan; Sang Yup Lee; Shahram Shafie; Botond Bertók; Ferenc Friedler

2005-01-01

320

Renal impairment in multiple myelomas  

Microsoft Academic Search

Objective  The aim of the study was to investigate the clinic manifestation, diagnosis and treatment on multiple myeloma (MM) with the\\u000a onset of renal impairment.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  The 27 cases of multiple myeloma with the onset of renal impairment were collected in Department of Nephrology, Wuhan General\\u000a Hospital of Guangzhou Command, China, from January 2007 to January 2011. All cases were divided into

Cheng Yang; Tianbiao Lan; Yi Cheng

2011-01-01

321

Multiple Sequence Alignment with DIALIGN.  

PubMed

DIALIGN is a software tool for multiple sequence alignment by combining global and local alignment features. It composes multiple alignments from local pairwise sequence similarities. This approach is particularly useful to discover conserved functional regions in sequences that share only local homologies but are otherwise unrelated. An anchoring option allows to use external information and expert knowledge in addition to primary-sequence similarity alone. The latest version of DIALIGN optionally uses matches to the PFAM database to detect weak homologies. Various versions of the program are available through Göttingen Bioinformatics Compute Server (GOBICS) at http://www.gobics.de/department/software . PMID:24170403

Morgenstern, Burkhard

2014-01-01

322

Multiple resonant railgun power supply  

DOEpatents

A multiple repetitive resonant railgun power supply provides energy for repetitively propelling projectiles from a pair of parallel rails. A plurality of serially connected paired parallel rails are powered by similar power supplies. Each supply comprises an energy storage capacitor, a storage inductor to form a resonant circuit with the energy storage capacitor and a magnetic switch to transfer energy between the resonant circuit and the pair of parallel rails for the propelling of projectiles. The multiple serial operation permits relatively small energy components to deliver overall relatively large amounts of energy to the projectiles being propelled.

Honig, Emanuel M. (Los Alamos, NM); Nunnally, William C. (Los Alamos, NM)

1988-01-01

323

Multigenre, Multiple Intelligences, and Transcendentalism.  

ERIC Educational Resources Information Center

|Explains an eleventh grade literature unit on Transcendentalism which employed a wide variety of supplemental materials and literary connections and which provided alternate assessment opportunities. Details how this unit revealed meaningful connections through comics, music, free reading, and multiple intelligences. Concludes that many students…

Ruggieri, Colleen A.

2002-01-01

324

Multiple station thermal diffusivity instrument.  

National Technical Information Service (NTIS)

A multiple furnace laser flash thermal diffusivity system has been developed. The system is equipped with a movable Nd:Glass laser unit, two IR detectors and furnaces for precise measurements of thermal diffusivity over the temperature range from (minus)1...

H. Wang R. B. Dinwiddie P. S. Gaal

1995-01-01

325

Multiple Literacies Theory: Exploring Futures  

ERIC Educational Resources Information Center

|This article focuses on the contributions of philosophy, art and science to education through the conceptual, theoretical, and methodological usefulness of a Deleuze-Guattarian conceptual framework that informs multiple literacies theory (MLT). Education lends itself to Deleuze's notion of connecting and creating through philosophy, art and…

Masny, Diana

2011-01-01

326

Remote multiple string well completion  

SciTech Connect

In a remotely installed underwater well apparatus, a tubular body, typically a multiple string tubing hanger, is landed in a position oriented rotationally with respect to a reference point on the apparatus and a seal device is then energized by the same tool employed to land and orient the tubular body.

Kirkland, K.G.

1981-09-15

327

Multiple Resources and Brain Laterality.  

National Technical Information Service (NTIS)

Two studies were completed to test the multiple resources model of information processing using tachistoscopic lateralized-input techniques. In Exp. 1 37 normal, dextral subjects, 18 men aged 18-21yr. and 19 women 18-21yr. responded manually to a visuo-sp...

E. H. Galluscio

1984-01-01

328

The multiple calculi of meaning  

Microsoft Academic Search

This article builds on investigations of practices of interpretation by linguistic anthropologists who, in their pursuit of challenges to Speech Act Theory, have alluded to but not yet fully explored how members of the same speech community make use of multiple, complex, and sometimes competing meaning-making practices within the same speech event. The argument is made that contexts of debate

Justin B. Richland

2006-01-01

329

Mass Customization and Multiple Intelligence  

Microsoft Academic Search

If the past millennium has led to more democracy, it is expected, that the new that has just started will lead to more amplified individualization. The trend to individualization is the basis on which Mass customization is founded and a key-element in Gardners Multiple Intelligence Theory, which has powerful implications for the education sector and for the workplace. This paper

Robert J. Freund

330

Multiple Choice Questions for Groundwater  

NSDL National Science Digital Library

This online quiz was written by Dr. John C. Butler at the University of Houston for 100-level geology students. There are 44 multiple choice questions and 8 fill in the blank questions, Topics include groundwater resources, the water cycle, karst features, the water table and parts of an aquifer. Answers are linked directly from the quiz page.

Butler, John C.; Houston, University O.

331

Assessment of Multiplication Fact Fluency  

ERIC Educational Resources Information Center

This project had two major goals: to determine the usefulness of individually-administered interview process to access elementary students' fluency with basic multiplication facts, and to determine whether a developmental sequence found in Australian mathematics education literature applied to elementary students in the United States. Students in…

Ford, Marilyn Sue; Usnick, Virginia

2011-01-01

332

[Multiple carpometacarpal dislocations. Five cases].  

PubMed

The authors report 5 cases treated and reviewed in their centre, together with the clinical and radiological results. Multiple carpometacarpal dislocations of all of the triphalangeal fingers are rare lesions induced by high-energy trauma, in which the therapeutic strategy is controversial. PMID:9479438

Diez, E; Marti, D; Aramburo, F; Mendez, J M

1997-01-01

333

Fungible Weights in Multiple Regression  

ERIC Educational Resources Information Center

Every set of alternate weights (i.e., nonleast squares weights) in a multiple regression analysis with three or more predictors is associated with an infinite class of weights. All members of a given class can be deemed "fungible" because they yield identical "SSE" (sum of squared errors) and R[superscript 2] values. Equations for generating…

Waller, Niels G.

2008-01-01

334

The dynamics of multiple sclerosis  

Microsoft Academic Search

The history of our understanding of the pathogenesis and pathophysiology of multiple sclerosis are reviewed in the context of Charcot's contribution. The implications for treatment of the new knowledge gained from studies during life of pathology and pathogenesis (by MRI) and pathophysiology (by evoked potentials) are reviewed.

W. I. McDonald

1993-01-01

335

Diagnostic criteria for multiple sclerosis  

Microsoft Academic Search

Over a hundred years ago, Charcot set down what he considered to be some of the clinical characteristics of multiple sclerosis (MS). His triad was not specific but it was the first attempt to separate this disease from the many others affecting the nervous system. The history of clinical diagnostic criteria demonstrates the evolution from rather tentative classifications of restricted

Charles M Poser; Vesna V Brinar

2001-01-01

336

Escalating Immunotherapy of Multiple Sclerosis  

Microsoft Academic Search

The promising results of several multicenter studies during the last few years have improved the immunomodulatory treatment of multiple sclerosis (MS). The different compounds tested were shown to reduce the number of relapses and to modulate the course of disease to various extents. The transition of the results obtained in therapeutic trials into daily clinical practice is often delayed or

P. Rieckmann; K. V. Toyka

1999-01-01

337

Bronchogenic cyst with multiple complications  

PubMed Central

Bronchogenic cysts are a rare type of mediastinal mass thought to arise from abnormal budding of the embryologic foregut. This paper presents a rare case of a 32-year-old male who developed multiple serious complications from a bronchial cyst. This rare presentation is discussed and the role of CT and MR imaging in making the diagnosis is highlighted.

Marshall, G; Cheah, C; Lenzo, NP

2007-01-01

338

Novel therapies for multiple myeloma.  

PubMed

Multiple myeloma (MM) continues to evade cure by conventional therapies, increasing the urgency for new, biologically based treatments. Reviewed in this discussion are novel chemotherapies under clinical trial that capitalize upon greater comprehension of tumor pathophysiology. In targeting tumor biology, these therapies serve as a model of treatment with great potential for improving outcomes in patients with MM. PMID:12163002

Ryoo, Joan J; Cole, Craig Emmitt; Anderson, Kenneth C

2002-09-01

339

Multiple Impacts on Monolithic Steel.  

National Technical Information Service (NTIS)

The multiple impacts on a monolithic, semi-infinite steel target of a shaped-charge jet in a particulated state were computer simulated by right circular cylinders, having a diameter of 3 mm and moving initially at 5 km/s. The penetration histories of two...

V. Kucher

1982-01-01

340

Multiple Sclerosis and Optic Neuritis.  

National Technical Information Service (NTIS)

The literature review of the relationship of optic neuritis (ON) in multiple sclerosis (MS) is presented. It is our goal to review the world's literature to: (1) see what subpopulation of ON was identified to be at high risk for MS; (2) present a standard...

M. S. Katchen

1991-01-01

341

Childhood Multiple Sclerosis: A Review  

ERIC Educational Resources Information Center

Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS) that is increasingly recognized as a disease that affects children. Similar to adult-onset MS, children present with visual and sensory complaints, as well as weakness, spasticity, and ataxia. A lumbar puncture can be helpful in diagnosing MS when…

Waldman, Amy; O'Connor, Erin; Tennekoon, Gihan

2006-01-01

342

Assessment of Multiplication Fact Fluency  

ERIC Educational Resources Information Center

|This project had two major goals: to determine the usefulness of individually-administered interview process to access elementary students' fluency with basic multiplication facts, and to determine whether a developmental sequence found in Australian mathematics education literature applied to elementary students in the United States. Students in…

Ford, Marilyn Sue; Usnick, Virginia

2011-01-01

343

Enhancing Learning through Multiple Intelligences  

ERIC Educational Resources Information Center

|This study investigated whether there was a significant difference between multiple intelligence instruction (MII) and traditionally designed science instruction (TDSI) on fourth grade students' understanding of concepts associated with the "Diversity of Living Things" unit. Students' intelligence types were also examined. There were two…

Ozdemir, Pinar; Guneysu, Sibel; Tekkaya, Ceren

2006-01-01

344

Algorithm for multiple faces tracking  

Microsoft Academic Search

Robust real-time face tracking is a challenging task. This paper presents an algorithm for tracking faces of multiple people even in case of total occlusion. The method uses the color distribution of each face with the mean shift tracking method. Mean shift tracking is fast and robust to partial occlusion, and it is rotation invariant and computationally efficient. Since the

Charay Lerdsudwichai; Mohamed Abdel-Mottaleb

2003-01-01

345

XRAY: Instrumentation for multiple computers  

Microsoft Academic Search

XRAY presents a global view of the performance of hardware and software components on multiple, distributed computers. The set of components chosen for measurement can be changed at any time throughout a network of systems, and can be selected to minimize data collection time and measurement space. In the course of normal activities the operating system executes firmware which increments

Russ Blake

1980-01-01

346

The neuroimmunology of multiple sclerosis  

Microsoft Academic Search

The aim of this clinical review is to highlight recent advances in immunology, as well as new information from selected other areas, which have led to a better appreciation of the neuroimmunologic mechanisms involved in Multiple sclerosis (MS). New data on immunopathology, the cytokine network, and the role of oligodendrocytes, lymphocytes, and endothelial cells in this disease, have produced novel

P. K. Coyle

1996-01-01

347

Corpus callosum in multiple sclerosis  

Microsoft Academic Search

A neuropathological study of 20 multiple sclerosis brains using celloidin-embedded slices was carried out to assess the extent of changes in the corpus callosum. Severe atrophy of the callosum was found in cases with marked hydrocephalus. Demyelination of the callosum varied in extent from slight involvement (with a few small plaques) to almost total myelin loss. A clinical history of

R. O. Barnard; Margaret Triggs

1974-01-01

348

Vitamin D and Multiple Sclerosis  

Microsoft Academic Search

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system and characterized by neurological and cognitive manifestations. The disease is more common in populations living in high altitudes with low sun exposure, women more than men and certain ethnic backgrounds more than others. The etiology of MS is yet unknown, although several factors have been implicated in its

Lini Alappat; Atif B Awad

2011-01-01

349

Multiple Intelligence for Every Classroom  

Microsoft Academic Search

This article presents an overview of multiple intelligence (MI) theory along with practical applications of the model. In particular, three basic aspects of the theory (teaching strategies, curricular adaptations, and student assessment) are described relative to the infusion of MI theory in general education classrooms to ensure appropriate inclusion for students with mild to moderate disabilities.

Pokey Stanford

2003-01-01

350

Multiple Risk Factor Intervention Trial.  

National Technical Information Service (NTIS)

The Multiple Risk Factor Intervention Trial is a primary prevention trial to determine the extent to which mortality from coronary heart disease may be reduced by the reduction of blood cholesterol, blood pressure and cigarette smoking in high risk men ag...

1975-01-01

351

Multiple Risk Factor Intervention Trial.  

National Technical Information Service (NTIS)

The Multiple Risk Factor Intervention Trial is a primary prevention trial to determine the extent to which mortality from coronary heart disease may be reduced by the reduction of blood cholesterol, blood pressure and cigarette smoking in high risk men ag...

1976-01-01

352

Fashion, Paper Dolls and Multiplicatives  

ERIC Educational Resources Information Center

|The multiplicative principle is the tool allowing the counting of groups that can be described by a sequence of events. An event is a subset of sample space, i.e. a collection of possible outcomes, which may be equal to or smaller than the sample space as a whole. It is important that students understand this basic principle early on and know how…

Ura, Suzana Kaori; Stein-Barana, Alzira C. M.; Munhoz, Deisy P.

2011-01-01

353

Presentation 7: Multiple Primary Rules  

Cancer.gov

MP Rules - Note 2 The registrar must recognize that during the diagnostic workup the physician may start with a non-specific diagnosis (NOS) and as testing is completed, a more specific histology is identified. These diagnoses are not multiple primaries; they represent steps in the diagnostic work-up. See rules M7-M12.

354

Pocket Guide to Multiple Intelligences.  

ERIC Educational Resources Information Center

|Howard Gardner's theory of multiple intelligences (1983) suggests that human cognitive competence is best described as a set of abilities, talents, or mental skills. All human beings possess each of these intelligences to some extent, but individuals differ in the levels of development and nature of their combination. The seven intelligences…

Shirley, Linda J.

355

Multiple Intelligences Theory in Action.  

ERIC Educational Resources Information Center

|The two articles in this newsletter issue focus on and discuss the multiple intelligences (MI) theory and its application in schools. Developed by Howard Gardner at Harvard University, the theory argues that individuals differ in their abilities, learning styles, and interests, and that these differences need to be acknowledged and nurtured in…

Lockwood, Anne Turnbaugh

1993-01-01

356

Multiple sequence alignment by consensus.  

PubMed Central

An algorithm for multiple sequence alignment is given that matches words of length and degree of mismatch chosen by the user. The alignment maximizes an alignment scoring function. The method is based on a novel extension of our consensus sequence methods. The algorithm works for both DNA and protein sequences, and from earlier work on consensus sequences, it is possible to estimate statistical significance.

Waterman, M S

1986-01-01

357

Consensus of multiple nonholonomic systems  

Microsoft Academic Search

This paper considers the consensus of multiple nonholonomic systems such that a group of systems converges to a desired trajectory. Cooperative control laws are proposed and analyzed with the aid of results from graph theory and Lyapunov analysis. The proposed control laws are decentralized. Robustness of the proposed control laws to communication delays is also considered. As an application of

Wenjie Dong; Jay A. Farrell

2008-01-01

358

Genomics in multiple myeloma research.  

PubMed

Multiple myeloma (MM) is the second most common hematological cancer. It is a very heterogeneous disease characterized by large genomic complexity, recurrent amplifications and/or deletions in the genome leading to different clinical manifestations and survival of patients. Thus, genomics plays an important role in identifying agents responsible for pathogenesis, prognosis and disease stratification of MM. PMID:21923062

Sevcíková, S; Nemec, P; Pour, L; Hájek, R

2011-01-01

359

Renal disease in multiple myeloma  

Microsoft Academic Search

Multiple myeloma is a malignant tumor of B (plasma) cells that is characterized by monoclonal immunoglobulin production. The incidence of myeloma is increasing worldwide, particularly among individuals of advanced age. Renal impairment at diagnosis is present in approximately 20% of patients with myeloma, and uremia is the cause of death in about 15%. Several renal disorders may be present in

Béla Iványi; Gyula Varga; Sándor Berkessy

1992-01-01

360

Improving Inferences from Multiple Methods.  

ERIC Educational Resources Information Center

|Multiple evaluation methods (MEMs) can cause an inferential challenge, although there are strategies to strengthen inferences. Practical and theoretical issues involved in the use by social scientists of MEMs, three potential problems in drawing inferences from MEMs, and short- and long-term strategies for alleviating these problems are outlined.…

Shotland, R. Lance; Mark, Melvin M.

1987-01-01

361

Multiple perspectives on online learning  

Microsoft Academic Search

This paper advocates an approach to the design, use and impact of new learning technologies that incorporates the view from multiple perspectives. This includes considering the questions and goals of students, faculty, administrators and co-workers, as well as social dimensions of learning, professional socialization, family dynamics, career, community formation, and institutional change.

Michelle M. Kazmer; Caroline Haythornthwaite

2005-01-01

362

Herpes Zoster and Multiple Sclerosis  

Microsoft Academic Search

No significant difference was found between 50 consecutive patients with multiple sclerosis and matched controls in respect of previous infection with rubella or measles and chicken-pox, or of previous vaccination and immunizing injections. Significantly more patients had a past history of herpes zoster compared with the controls.

J. A. R. Lenman; T. J. Peters

1969-01-01

363

Bacterial toxins and Multiple Sclerosis  

Microsoft Academic Search

The primary pathogenetic mechanism responsible for the distinctive demyelinating lesions in the Central Nervous System (CNS) in Multiple Sclerosis (MS), first described in remarkable detail by Charcot more than 170 years ago, remains one of the most baffling conundrums in medicine. A possible role for bacterial cell molecules and transportable proteins in the pathogenesis of MS is reviewed. The ability

Frederick Gay

2007-01-01

364

Multiple venous aneurysms of neck  

PubMed Central

Venous aneurysm of neck is a rare anomaly, usually presenting as a painless mass which increases in size on valsalva maneuver. A child with multiple aneurysms of the right common facial and external jugular veins diagnosed on Doppler ultrasonography and magnetic resonance venography is reported.

Swaika, Sweta; Basu, Sudipta; Bhadra, Ram C.; Maitra, Sujay

2013-01-01

365

Plasmablastic transformation of multiple myeloma  

Microsoft Academic Search

We describe morphological, immunophenotypic, and cytogenetic characterization of a case of multiple myeloma (MM) that showed plasmablastic transformation at the terminal phase with a picture resembling acute leukemia. The plasmablasts expressed monotypic cytoplasmic immunoglobulin together with myeloid and megakaryocytic markers at disease transformation. Conventional cytogenetic study of bone marrow cells showed coexistence of hypodiploid and hyperdiploid cells, with the former

Cheuk Kwong Lee; Edmond S. K Ma; Tony W. H Shek; Clarence C. K Lam; Wing Yan Au; Thomas S. K Wan; Li Chong Chan

2003-01-01

366

Cerebral palsy and multiple births  

Microsoft Academic Search

AIM: To compare the birthweight specific prevalence of cerebral palsy in singleton and multiple births. METHODS: Registered births of babies with cerebral palsy born to mothers resident in the counties of Merseyside and Cheshire during the period 1982 to 1989 were ascertained. RESULTS: The crude prevalence of cerebral palsy was 2.3 per 1000 infant survivors in singletons, 12.6 in twins,

P O Pharoah; T Cooke

1996-01-01

367

The ALICE Forward Multiplicity Detector  

NASA Astrophysics Data System (ADS)

The ALICE Forward Multiplicity Detector (FMD) is a silicon strip detector with 51,200 strips arranged in 5 rings, covering the range -3.4 < ? < 5.1. It is placed around the beam pipe at small angles to extend the charged particle acceptance of ALICE into the forward regions, not covered by the central barrel detectors.

Christensen, Christian Holm; Gaardhøje, Jens Jørgen; Gulbrandsen, Kristján; Nielsen, Børge Svane; Søgaard, Carsten

368

Multiple Pathways for All Students  

ERIC Educational Resources Information Center

|Maine has been focusing on the importance of postsecondary training. Maine's Skowhegan Area High School (SAHS) and Somerset Career and Technical Center (SCTC) have partnered in a Multiple Pathways initiative (funded by the Nellie Mae Education Foundation) to increase students' high school completion rate and to increase enrollment in…

Stirling, Lee Anna

2012-01-01

369

Inverted and multiple nematic emulsions  

Microsoft Academic Search

We investigate experimentally the structures that form when small colloidal particles are suspended in a nematic solvent. These structures are anisotropic, and their formation is driven by interactions arising from the orientational elasticity of the nematic solvent. By using inverted and multiple nematic emulsions composed of water droplets dispersed in a thermotropic liquid crystal, we identify the nature of these

P. Poulin; D. A. Weitz

1998-01-01

370

Childhood Multiple Sclerosis: A Review  

ERIC Educational Resources Information Center

|Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS) that is increasingly recognized as a disease that affects children. Similar to adult-onset MS, children present with visual and sensory complaints, as well as weakness, spasticity, and ataxia. A lumbar puncture can be helpful in diagnosing MS when…

Waldman, Amy; O'Connor, Erin; Tennekoon, Gihan

2006-01-01

371

Symptomatic Treatment of Multiple Sclerosis  

Microsoft Academic Search

Besides immunomodulation and immunosuppression, the specific treatment of symptoms is an essential component of the overall management of multiple sclerosis (MS). Symptomatic treatment is aimed at the elimination or reduction of symptoms impairing the functional abilities and quality of life of the affected patients. Moreover, with symptomatic treatment the development of a secondary physical impairment due to an existing one

T. Henze; P. Rieckmann; K. V. Toyka

2006-01-01

372

Learning Multiplication: The Easy Way  

ERIC Educational Resources Information Center

|In this article, the author presents an innovative approach to teaching multiplication facts for children in middle school or younger. After introducing the dangers of some contradictions that persist, relating a brief summary of related research and guidelines regarding math facts and their relation to strategic approaches to more complex math,…

Caron, Thomas A.

2007-01-01

373

Prenatal diagnosis in multiple pregnancy  

Microsoft Academic Search

Fetal abnormality is more common in multiple than in singleton pregnancies. This, together with the requirement to consider the risks with at least two babies to sample correctly each fetus and to undertake accurately-targeted selective termination, amounts to a major challenge for obstetricians involved in prenatal diagnosis. Early determination of chorionicity should be routine, since this influences not only the

Myles J. O. Taylor; Nicholas M. Fisk

2000-01-01

374

Montgomery Multiplication in GF(2k)  

Microsoft Academic Search

We showthat the multiplication operation c = a · b · r?1 in the field GF(2k) can be implemented significantly faster in software than the standard multiplication, where r is a special fixed element of the field. This operation is the finite field analogue of the Montgomery multiplication for modular multiplication of integers. We give the bit-level and word-level algorithms

CETIN K. KOCAND; TOLGA ACAR

375

SOMATIC SYMPTOMS IN MULTIPLE SCLEROSIS AND MPD  

Microsoft Academic Search

In this report 50 subjects with multiple sclerosis are compared to 50 subjects with multiple personality disorder. The multiple sclerosis patients endorsed an average (1 3.0 somatic symptoms on structuredinterview, the multiple personality subjects an average of 14.5. The somatic symptoms characteristic of neurological illness were trouble walking, paralysis, and muscle weakness. Those characteristic of psychiatric illness were genitourinary and

Colin A. Ross; Geri Anderson; Anthony Auty; Judy Todd; Cohn A. Ross

376

On the Time Required to Perform Multiplication  

Microsoft Academic Search

The time required to perform multiplication is investigated. A lower bound on the time required to perform multiplication, as well as multiplication modulo N, is derived and it is shown that these lower bounds can be approached. Then a lower bound on the amount of time required to perform the most significant part of multiplication (⌞xy\\/N⌟) is derived.

Shmuel Winograd; Yorktown Heights

1967-01-01

377

Dean's Great Discovery: Multiplication, Division and Fractions  

ERIC Educational Resources Information Center

Multiplication, division and fractions are "hotspots" for students in the middle years with many students experiencing difficulty with these concepts. Arrays effectively model multiplication and help children develop multiplicative thinking and learn multiplication facts. In this article the authors show how an open-ended array problem enabled a…

Vale, Colleen; Davies, Anne

2007-01-01

378

Multiple selections in smart text editing  

Microsoft Academic Search

Multiple selections, though heavily used in file managers and drawing editors, are virtually nonexistent in text editing. This paper describes how multiple selections can automate repetitive text editing. Selection guessing infers a multiple selection from positive and negative examples provided by the user. The multiple selection can then be used for inserting, deleting, copying, pasting, or other editing commands. Simultaneous

Robert C. Miller; Brad A. Myers

2002-01-01

379

Interferon Treatment of Multiple Sclerosis  

PubMed Central

Introduction: In the treatment of Multiple Sclerosis (MS) differ: treatment of relapse, treatment slow the progression of the disease (immunomodulators and immunosuppression), and symptomatic treatment. The aim: The aim of this study is to analyze the application of interferon therapy in the treatment of MS-E: Process the disease, patients with multiple sclerosis who have passed the commission for multiple sclerosis at the Neurology Clinic of Clinical Center of Sarajevo University as a reference center for referral to the Commission for multiple sclerosis from the Federal Ministry of Health in 2009 year in terms of total number examined, gender differences, diagnostic tests (MRI, CSF, EP), neurological findings and EDSS scores. Provide a section through the continuous support and education of patients during the introduction Betaferon in therapy with the goal of education for self-use and reduce the incidence of side effects of interferon therapy. Materials and methods: The material for the work they were histories of patients who are registered as patients who have undergone a commission for MS at Department of Neurology, University Clinical Center in Sarajevo. The evaluation was retrospective. It was used a specially designed form, which is usually applied to patients referred to this committee. After the collected material was carried out data processing. The study comprised 34 patients who have undergone a commission of which 16 patients received interferon therapy. Results: In 2009 at the Neurology Clinic CCUS have treated 34 patients who passed the committee for recommendation to interferon therapy (25 women and 9 men). The diagnosis of multiple sclerosis is safe based on the criteria of international panel in 2000. EDSS Average score for men was 1.8, 1.9 for women, the total EDSS score was 1.8. The gender ratio is 3:1 in women than in men. Sixteen patients received interferon by the Commission for multiple sclerosis, the Federal Ministry of Health and their therapy was initiated at the clinic. Conclusion: For the period of 2009, a total of 34 patients were examined with multiple sclerosis who received interferon treatment recommendations at the expense of the Federal Solidarity Fund at the Neurology Clinic CCUS Sarajevo. The average EDSS score was 1.8. There were no significant differences in neurological findings between patients who were previously treated with interferon and patients who were waiting for treatment.

Alajbegovic, Azra; Deljo, Dervis; Alajbegovic, Salem; Djelilovic-Vranic, Jasminka; Todorovic, Ljubica; Tiric-Campara, Merita

2012-01-01

380

Software Portability Considerations for Multiple Applications over Multiple Sites  

PubMed Central

There are great benefits to be obtained by distributing the cost of software development over multiple sites. Both economies and dis-economies of scale become prominent when broad-based software portability is looked at carefully. However, traditional data processing techniques are oriented to making specific users, rather than general software for a class of users. This trend toward overspecification is getting worse with traditional data processing languages, while other standard languages are confronting it.

Munnecke, Thomas

1981-01-01

381

Multiple sclerosis genetics: leaving no stone unturned  

Microsoft Academic Search

Compelling epidemiologic and molecular data indicate that genes play a primary role in determining who is at risk for developing multiple sclerosis (MS), how the disease progresses, and how someone responds to therapy. The genetic component of MS etiology is believed to result from the action of allelic variants in several genes. Their incomplete penetrance and moderate individual effect probably

J R Oksenberg; L F Barcellos; JR Oksenberg

2005-01-01

382

Adaptation to Change in Multiple Probability Tasks.  

National Technical Information Service (NTIS)

The findings reported here indicate that adaptation to change in a multiple-cue, probabilistic task is substantially affected by which aspects of the task undergo change. Both (a) the initial decrement in performance and (b) the rate of improvement follow...

D. A. Summers

1968-01-01

383

Zoom Zoom: racing CARs for multiple myeloma.  

PubMed

Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma. PMID:23444214

Maus, Marcela V; June, Carl H

2013-02-26

384

Solitary versus multiple cholesterol gallbladder stones  

Microsoft Academic Search

The development and growth pattern of solitary and multiple cholesterol gallbladder stones was defined using cholecystography in a prospective study of 48 patients whose initial cholecystograms indicated a stone-free gallbladder and who developed gallstones within the subsequent 5 years. Radiological observations performed over 365 patient-years were complemented by macroscopic examination, radiograms, scanning electron microscopy, and chemical analysis of gallstones from

C. Wolpers; A. F. Hofmann

1993-01-01

385

Criticality of predictors in multiple regression  

Microsoft Academic Search

A new method is proposed for comparing all predictors in a multiple regression model. This method generates a measure of predictor criticality, which is distinct from and has several advantages over traditional indices of predictor importance. Using the bootstrapping (resampling with replacement) procedure, a large number of samples are obtained from a given data set which contains one response variable

Razia Azen; David V. Budescu; Benjamin Reiser

2001-01-01

386

Multiple sclerosis and parainfluenza 1 virus  

Microsoft Academic Search

54 cultures were established from brain tissue obtained 2–3 hrs after death from 1 case of multiple sclerosis and 30 cultures from another case. Following fusion with indicator cells in the presence of lysolecithin, a parainfluenza type 1 virus (6\\/94 virus) was isolated from cultures representing one plaque area in the first case and one plaque area in the second

Hilary Koprowski; Volker Meulen

1975-01-01

387

Demand Characteristics of Multiple-Choice Items.  

ERIC Educational Resources Information Center

|Thirteen graduate students were asked to indicate for each of 24 multiple-choice items whether the item tested "recall of specific information," a "higher order skill," or "don't know." The students were also asked to state their general basis for judging the items. The 24 items had been previously classified according to Bloom's cognitive-skills…

Diamond, James J.; Williams, David V.

388

Professional Skepticism of Multiple Personality Disorder  

Microsoft Academic Search

If you saw a patient who appeared to have more than one personality, what diagnosis would you make? And how would you vary your clinical approach? Data from 425 respondents indicated that the majority of psychologists believed multiple personality disorder (MPD) to be a valid but rare clinical diagnosis. Respondents cited extreme child abuse as the foremost cause of MPD.

Jane F. Cormier; Mark H. Thelen

1998-01-01

389

Multiple Bound States of Nonlinear Schrödinger Systems  

NASA Astrophysics Data System (ADS)

This paper is concerned with existence of bound states for Schrödinger systems which have appeared as several models from mathematical physics. We establish multiplicity results of bound states for both small and large interactions. This is done by different approaches depending upon the sizes of the interaction parameters in the systems. For small interactions we give a new approach to deal with multiple bound states. The novelty of our approach lies in establishing a certain type of invariant sets of the associated gradient flows. For large interactions we use a minimax procedure to distinguish solutions by analyzing their Morse indices.

Liu, Zhaoli; Wang, Zhi-Qiang

2008-09-01

390

Time-domain multiple-quantum NMR  

SciTech Connect

The development of time-domain multiple-quantum nuclear magnetic resonance is reviewed through mid 1982 and some prospects for future development are indicated. Particular attention is given to the problem of obtaining resolved, interpretable, many-quantum spectra for anisotropic magnetically isolated systems of coupled spins. New results are presented on a number of topics including the optimization of multiple-quantum-line intensities, analysis of noise in two-dimensional spectroscopy, and the use of order-selective excitation for cross polarization between nuclear-spin species.

Weitekamp, D.P.

1982-11-01

391

Network multiple frame assignment architectures  

NASA Astrophysics Data System (ADS)

Multiple target tracking methods divide into two broad classes, namely single frame and multiple frame methods. The most successful of the multiple frame methods are multiple hypothesis tracking (MHT) and multiple frame assignments (MFA). In dense tracking environments the performance improvements of multiple frame methods over single frame methods are very significant, making it the preferred solution for many tracking problems. A centralized architecture in which all measurements are sent to one location and processed with tracks being transmitted back to the different platforms is a simple one that is probably optimal in that it is capable of producing the best track quality and a consistent air picture. The centralized tracker is, however, unacceptable for several reasons, notably the communication overloads and single-point-failure. Thus, one must turn to a distributed architecture for both estimation/fusion and data association. One of the simplest network-centric architectures is that of placing a centralized tracker on each platform. The architecture is called Network MFA Centralized, which removes the problem of single-point-failure. Each composite tracker is making its own tracking decisions based on the data it receives, regardless of decisions of other platforms. Therefore, a consistent air picture may not be achieved across the network due to communication delays. The objective of this thesis is the development of two near-optimal Network MFA architectures, namely Network MFA on Local Data and Network Tracks and Network MFA on All data and Network Tracks, that preserve the quality of a centralized tracker across the platforms while managing communication loading and achieving a consistent air picture. One technique that has proved useful for achieving SIAP is to require that each platform be in charge of assigning its own measurements to the network tracks. In the architecture of Network MFA on Local Data, only local data are used in the sliding windows. In the architecture of Network MFA on All Data, remote data as well as local data are used in the sliding window. The results of extensive computations are presented to validate the differences in four tracking architectures.

Lu, Suihua

392

Moving target tracking using multiple sensors  

NASA Astrophysics Data System (ADS)

Multiple Sensors improve tracking performance. The Kinematic Automatic Tracker (KAT) may drop a track when the Joint STARS aircraft is turning or the track is screened. In situation like this multiple sensors can improve tracking performance. Two algorithms for tracking moving targets using multiple sensors are developed. Both algorithms are based on modifying the existing KAT architecture. The first approach is based on the use of the best sensor's Moving Target Indicators (MTIs) when the sensors have overlapping dwells. The second and more general approach uses the report-to-track fusion algorithm. The first approach is frame- based (with multiple dwells), whereas the second approach is dwell- based. The tracking results are presented for the first algorithm for a two-sensors Korean scenario with increasing complexity. We also show the advantages of using multiple sensors for tracking using a simulated Korea scenario. For the report-to-track fusion algorithm, we present preliminary tracking results for a simulated scenario using two UAV sensors.

Lodaya, Manikant D.; Bottone, Richard

2000-07-01

393

Dissonance of multiple Devil's staircases  

NASA Astrophysics Data System (ADS)

Recently people noted that in some discontinuous maps a kind of multiple Devil's staircases may appear ( S.-X. Qu, S. Wu, and D.-R. He, Phys. Rev. E 57, 402 (1998)). A multiple Devil's staircase is composed of many towerlike structures. The corresponding phase-locked plateaus in the towers are positioned along smooth and monotonic curves. We found that some extremely high or low towers may ruin this harmony. This dissonance may be described by the number of the kinds of the branches in the towers. It corresponds to the number of modes of collision between the periodic orbits and discontinuities of the mapping. We also show that the relationship between these two numbers is true for the general cases.

Wang, Xu-Ming; Qu, Shi-Xian; He, Da-Ren; Mao, Jian-Shan; Zhou, Zheng-Xin

2000-03-01

394

Subcritical multiple-ion shocks  

SciTech Connect

Low Mach number collisionless shocks in a multiple-ion plasma are investigated theoretically using multiple-ion Rankine-Hugoniot relations (MIRHR) and hybrid simulations. The derived MIRHR permit tractable solutions for perpendicular shocks. It is found that starting from a synchronous flow of a mixture of different ion species, light ions and heavy ions jump to different downstream velocities. Although the resulting differential velocities between the species are unstable, they produce coherent gyration of the ion species around each other. This gyration excites standing ion hybrid waves in the downstream region. Both of these effects (the jump of different ion species ot different downstream velocities and the excitation of the ion hybrid waves) are confirmed by hybrid simulations.

Motschmann, U.; Sauer, K.; Roatsch, T. (Space Research Inst., Berlin (West Germany)); McKenzie, J.F. (Max-Planck-Inst. for Aeronomy, Katlenburg-Lindau (Germany))

1991-08-01

395

Silhouette Segmentation in Multiple Views.  

PubMed

In this paper, we present a method for extracting consistent foreground regions when multiple views of a scene are available. We propose a framework that automatically identifies such regions in images under the assumption that, in each image, background and foreground regions present different color properties. To achieve this task, monocular color information is not sufficient and we exploit the spatial consistency constraint that several image projections of the same space region must satisfy. Combining monocular color consistency constraint with multi-view spatial constraints allows to automatically and simultaneously segment the foreground and background regions in multi-view images. In contrast to standard background subtraction methods, the proposed approach does not require a priori knowledge of the background nor user interaction. Experimental results under realistic scenarios demonstrate the effectiveness of the method for multiple camera setups. PMID:21079278

Lee, Wonwoo; Woo, Woontack; Boyer, Edmond

2010-11-01

396

Multiple Exciton Generation Solar Cells  

SciTech Connect

Heat loss is the major factor limiting traditional single junction solar cells to a theoretical efficiency of 32%. Multiple Exciton Generation (MEG) enables efficient use of the solar spectrum yielding a theoretical power conversion efficiency of 44% in solar cells under 1-sun conditions. Quantum-confined semiconductors have demonstrated the ability to generate multiple carriers but present-day materials deliver efficiencies far below the SQ limit of 32%. Semiconductor quantum dots of PbSe and PbS provide an active testbed for developing high-efficiency, inexpensive solar cells benefitting from quantum confinement effects. Here, we will present recent work of solar cells employing MEG to yield external quantum efficiencies exceeding 100%.

Luther, J. M.; Semonin, O. E.; Beard, M. C.; Gao, J.; Nozik, A. J.

2012-01-01

397

Treating multiple sclerosis with natalizumab.  

PubMed

Natalizumab is the first monoclonal antibody approved for the treatment of relapsing multiple sclerosis. Pivotal trials demonstrated the efficacy of natalizumab on clinical and paraclinical measures of disease activity and disability progression. Although a direct comparison has not been performed yet, natalizumab seems to be more efficacious than the currently available immunomodulant drugs, such as IFN-? and glatiramer acetate. Despite its efficacy, the occurrence of an increased risk of progressive multifocal leukoencephalopathy with the treatment, raises concerns about its widespread use in multiple sclerosis patients. This paper provides an overview of the most relevant results from the Phase I-IV studies on natalizumab and highlights the challenges addressed to minimize and manage its adverse events in clinical practice. PMID:22091593

Iaffaldano, Pietro; Lucchese, Guglielmo; Trojano, Maria

2011-12-01

398

Intrascrotal and extratesticular multiple schwannoma.  

PubMed

Schwannoma, which may occur in any region of the body, is very rare in the scrotum. Schwannomas are tumors that originate from Schwann cells and, theoretically, could affect any nerve. In spite of the rich innervation of the genital area, these kinds of tumors are not common in the scrotum. A 67-year-old man visited our hospital for investigation of a 2-year episode of multiple slowly growing masses in the scrotum. Testicular tumor markers were within normal range (beta human chorionic gonadotropin <5 mIU, ?-fetoprotein : 4.86 ng/ml). Scrotal ultrasonography revealed intrascrotal and extratesticular masses in the mid-scrotal region. Complete excision of the scrotal masses was performed. After surgery there was no testicular invasion. Histological examination of the resected specimen showed them to be schwannomas of the scrotum. We report one case of multiple schwannomas of the scrotum with a review of the literature. PMID:24044115

Kim, Young-Joo; Kim, Sung Dae; Huh, Jung-Sik

2013-08-31

399

Intrascrotal and Extratesticular Multiple Schwannoma  

PubMed Central

Schwannoma, which may occur in any region of the body, is very rare in the scrotum. Schwannomas are tumors that originate from Schwann cells and, theoretically, could affect any nerve. In spite of the rich innervation of the genital area, these kinds of tumors are not common in the scrotum. A 67-year-old man visited our hospital for investigation of a 2-year episode of multiple slowly growing masses in the scrotum. Testicular tumor markers were within normal range (beta human chorionic gonadotropin <5 mIU, ?-fetoprotein : 4.86 ng/ml). Scrotal ultrasonography revealed intrascrotal and extratesticular masses in the mid-scrotal region. Complete excision of the scrotal masses was performed. After surgery there was no testicular invasion. Histological examination of the resected specimen showed them to be schwannomas of the scrotum. We report one case of multiple schwannomas of the scrotum with a review of the literature.

Kim, Young-Joo; Kim, Sung Dae

2013-01-01

400

Bone markers in multiple myeloma.  

PubMed

Bone disease, a hallmark of multiple myeloma occurs in the majority of the patients, is associated with bone pain, fractures, hypercalcemia and has major impacts on quality of life. Myeloma is characterized by a unique form of bone disease with osteolytic bone destruction that is not followed by reactive bone formation, resulting in extensive lytic lesions. This review will focus on the pathophysiology of osteoclast activation and osteoblast inhibition in multiple myeloma and on biochemical markers of bone turnover. Since osteolytic lesions do not rapidly heal in myeloma, X-rays cannot reflect the activity of bone disease during antimyeloma treatment. Activity in bone turnover does not parallel changes in monoclonal protein levels. Thus, there is a need for biochemical markers reflecting disease activity in bone. The utility, prognostic implications and limitations of classical and novel markers of bone remodeling (e.g. ICTP, NTx, TRACP-5b, osteoprotegerin, sRANKL) will be discussed in this overview. PMID:16765040

Heider, Ulrike; Fleissner, Claudia; Zavrski, Ivana; Kaiser, Martin; Hecht, Monica; Jakob, Christian; Sezer, Orhan

2006-06-09

401

Paraquat detoxication with multiple emulsions.  

PubMed

In this study, we show that detoxifying W/O/W multiple emulsions, prepared with an appropriate extractant/trapping couple, represent a promising technology for quick and safe poisoning treatments, with application to the highly toxic herbicide Paraquat, responsible of poisonings from low-dose exposure leading to several deaths every year. In vitro tests led to the choice of an appropriate extractant/trapping couple system with significant detoxication performance. In vivo tests showed (i) that rats receiving high doses of Paraquat, then a detoxifying emulsion, presented an increase from 50% to 100% of the MST (median survival time) and (ii) that no mortality was observed during 30 days with rats dosed with emulsions initially loaded with Paraquat at a concentration much higher than the lethal dose, proving the stability and the inocuity of the detoxifying multiple emulsion in the gastrointestinal tract. PMID:19635538

Frasca, S; Couvreur, P; Seiller, M; Pareau, D; Lacour, B; Stambouli, M; Grossiord, J L

2009-07-25

402

Neurogenic bladder from multiple sclerosis  

Microsoft Academic Search

Multiple sclerosis (MS) is an autoimmune disorder affecting the central nervous system. Because MS is a chronic disease that\\u000a can affect any part of the central nervous system, most patients experience voiding dysfunction during the course of the disease.\\u000a Depending on the site of plaques within the central nervous system, various complaints may arise. Familiarity is required\\u000a with the evaluation

Brian L. Cohen; Line Leboeuf; Angelo E. Gousse

2008-01-01

403

Multiple Ligament Knee Injury: Complications  

PubMed Central

Non-operative and operative complications are common following multiple ligament knee injuries. This article will describe common complications seen by the surgeon and physical therapist following this complex injury. Complications include fractures, infections, vascular and neurologic complications following injury and surgery, compartment syndrome, complex regional pain syndrome, deep venous thrombosis, loss of motion and persistent laxity issues. A brief description of these complications and methods for evaluation and treatment will be described.

Hosseinzadeh, Pooya; Giangarra, Charles E.

2008-01-01

404

Switching therapies in multiple sclerosis.  

PubMed

There are currently nine approved disease modifying therapies for relapsing forms of multiple sclerosis, with six distinct mechanisms of action. All have side effects, and none are cures. When a patient cannot tolerate therapy, or there is unacceptable breakthrough disease activity, the most common approach is to change drug. No universal guidelines exist for switching therapy. This overview will propose switch principles and suggestions. PMID:23508518

Coyle, Patricia K

2013-04-01

405

Emerging therapies for multiple sclerosis  

Microsoft Academic Search

Summary  This review examines the mode of action, safety profile and clinical efficacy of some of the most promising new therapeutic\\u000a strategies for multiple sclerosis. Autologous hematopoietic stem cell transplantation can regenerate a new and tolerant immune\\u000a system and is a potentially effective rescue therapy in a subset of patients with aggressive forms of MS refractory to approved\\u000a immunomodulatory and immunosuppressive

Paolo A. Muraro; Bibiana Bielekova

2007-01-01

406

Multiple Imputation after 18+ Years  

Microsoft Academic Search

Multiple imputation was designed to handle the problem of missing data in public-use data bases where the data-base constructor and the ultimate user are distinct entities. The objective is valid frequency inference for ultimate users who in general have access only to complete-data software and possess limited knowledge of specific reasons and models for nonresponse. For this situation and objective,

Donald B. Rubin

1996-01-01

407

Multiple Endocrine Neoplasia Type I  

Microsoft Academic Search

Opinion statement  Multiple endocrine neoplasia type I is a rare autosomal dominant disorder with many endocrine and nonendocrine manifestations.\\u000a Hyperparathyroidism, islet cell tumors, and pituitary tumors are diagnosed most commonly in these patients. There is controversy\\u000a regarding treatment of the different manifestations and screening modalities of this disorder because no large series has\\u000a determined the best therapeutic approach. Our institution advocates

Rasa Zarnegar; Laurent Brunaud; Orlo H. Clark

2002-01-01

408

Multiple Viewpoint Recognition and Localization  

Microsoft Academic Search

\\u000a This paper presents a novel approach for labeling objects based on multiple spatially-registered images of a scene. We argue\\u000a that such a multi-view labeling approach is a better fit for applications such as robotics and surveillance than traditional\\u000a object recognition where only a single image of each scene is available. To encourage further study in the area, we have collected

Scott Helmer; David Meger; Marius Muja; James J. Little; David G. Lowe

2010-01-01

409

Multiple myeloma following essential thrombocythemia.  

PubMed

The association of essential thrombocythemia and multiple myeloma is extremely rare, with only three patients previously treated with hydroxyurea reported in the literature until now. In this paper, we report the case of a 66 year old male who developed IgG-kappa M six years after the diagnosis of essential thrombocythemia, for which he had received hydroyurea. The possible etiological and pathogenic link between both these entities is here discussed. PMID:23906574

Ben Youssef, Yosra; Gmidène, Abir; Bouabid, Zahreddine; Bouallegui, Sonia; Sriha, Badreddine; Zaier, Monia; Sennana, Hlima; Khelif, Abserrahim

410

Pain in multiple system atrophy  

Microsoft Academic Search

Pain is a recognized feature of idiopathic Parkinson’s disease (IPD) but has never been studied in multiple system atrophy\\u000a (MSA), the commonest cause of atypical parkinsonism. We retrospectively analysed histories of pain in 100 consecutive cases\\u000a of clinically probable MSA. Details were obtained from the medical records of 100 patients with MSA, comprising 82 with the\\u000a striatonigral degeneration (SND) type

F. Tison; G. K. Wenning; M. A. Volonte; W. R. Poewe; P. Henry; N. P. Quinn

1996-01-01

411

Math, Methods, and Multiple Intelligences  

Microsoft Academic Search

Mathematics can be taught in a variety of ways, which corresponds to the reality that children learn in different ways. Howard Gardner identified eight specific intelligences (e.g., verbal\\/linguistic, logical\\/mathematical, musical, bodilylkinesthetic, visual\\/spatial, interpersonal, intrapersonal, and naturalistic) through which children learn. In this study, the teaching and learning of mathematics was analyzed according to Gardner' s multiple intelligences through observations, interviews,

Setchell Patricia; Nillas

2005-01-01

412

Vitamin D and Multiple Sclerosis  

Microsoft Academic Search

\\u000a The etiology of multiple sclerosis (MS) is unknown, but there is growing evidence that vitamin D deficiency may contribute\\u000a to MS development. In this chapter we critically review the current evidence from epidemiological studies. Results of case–control\\u000a studies of childhood sun exposure and risk of MS are mixed, but largely support a protective effect with less sun exposure\\u000a reported by

Alberto Ascherio; Kassandra L. Munger

413

Distributive Property Matrix Multiplication (1)  

NSDL National Science Digital Library

This interactive Java learning tool allows a teacher to demonstrate and explore the distributive property with expressions in the factored form (a + b) (c + d) using a matrix multiplication method with students. Sliders determine the number values from 20 to -20 with increments of one-tenth. Check boxes show or hide the factored form, starting matrix values, matrix, products in the matrix, and solution.

Tierney-Fife, Peter

2009-02-20

414

Targeted therapies in multiple myeloma  

Microsoft Academic Search

Increasing knowledge of the biology of multiple myeloma led the way for the development of novel drugs that have changed the\\u000a management of the disease. New treatments target not only to the malignant plasma cell but also target the interactions of\\u000a myeloma cells with their microenvironment. Several preclinical studies have identified potential targets and drugs are developed\\u000a that act on

Efstathios Kastritis; Andreas Charidimou; Andreas Varkaris; Meletios A. Dimopoulos

2009-01-01

415

Multiple access caches: Energy implications  

Microsoft Academic Search

In this paper, we model and evaluate the energy consumption of three different multiple access cache architectures that target the reduction of access latencies of associative caches. Further, we compare their energy consumption with that of traditional direct-mapped and set-associative caches. Among all the cache architectures, the most recently used cache is found to be most energy-efficient for all studied

H. S. Kim; N. Vijaykrishnan; M. Kandemir; M. J. Irwin

2000-01-01

416

Bone health in multiple sclerosis  

Microsoft Academic Search

People who are disabled with multiple sclerosis (MS) may be at increased risk of osteoporosis. This review discusses issues\\u000a relevant to bone health in MS and makes practical recommendations regarding prevention and screening for osteoporosis and\\u000a fracture risk in MS. A search of the literature up until 5 April 2011 was performed using key search terms, and articles pertinent\\u000a to

J. C. Gibson; G. D. Summers

417

Multiple scattering in magnetic SESANS  

Microsoft Academic Search

Magnetic spin-echo SANS (SESANS) gives real-space information about correlations in a ferromagnetic material on a length scale 10–10000nm, inaccessible in conventional SANS. In non-magnetic SESANS correction for multiple scattering is done analytically. For magnetic SESANS we propose a modified formula and verify it by magnetic-SESANS measurements in stacks of copper plates with electro-deposited Ni. Such Ni film consists of domains

W. H. Kraan; V. N. Zabenkin; Yu. A. Chetverikov; M. Th. Rekveldt; C. P. Duif; S. V. Grigoriev

2007-01-01

418

Multiple scattering in magnetic SESANS  

Microsoft Academic Search

Magnetic spin-echo SANS (SESANS) gives real-space information about correlations in a ferromagnetic material on a length scale 10 10 000 nm, inaccessible in conventional SANS. In non-magnetic SESANS correction for multiple scattering is done analytically. For magnetic SESANS we propose a modified formula and verify it by magnetic-SESANS measurements in stacks of copper plates with electro-deposited Ni. Such Ni film

W. H. Kraan; V. N. Zabenkin; Yu. A. Chetverikov; M. Th. Rekveldt; C. P. Duif; S. V. Grigoriev

2007-01-01

419

Multiple target laser ablation system  

DOEpatents

A laser ablation apparatus and method are provided in which multiple targets consisting of material to be ablated are mounted on a movable support. The material transfer rate is determined for each target material, and these rates are stored in a controller. A position detector determines which target material is in a position to be ablated, and then the controller controls the beam trigger timing and energy level to achieve a desired proportion of each constituent material in the resulting film. 3 figs.

Mashburn, D.N.

1996-01-09

420

Clinical aspects of multiple pregnancy  

Microsoft Academic Search

The natural wonder of multiple pregnancy and birth has fascinated mankind\\u000asince ancient times and twins figure prominently in legends, folktales and myths.\\u000aOne of the best known traditional stories is that of Romulus and Remus, the twins\\u000awho were abandoned on the banks of the Tiber and suckled by a she-wolf. Later\\u000aRomulus founded Rome, the city that still

J. G. Santema

1996-01-01

421

Gene therapy of multiple sclerosis  

Microsoft Academic Search

\\u000a Multiple sclerosis (MS) constitutes a difficult challenge for the design of innovative therapies: the aetiology is unknown,\\u000a the pathogenesis only partially understood, and the whole process is multi-focal, chronic, and occurring beyond anatomical\\u000a barriers, making the delivery of potentially therapeutic molecules difficult. Gene therapy, thus, constitutes a realistic\\u000a alternative to ensure prolonged, and site-specific delivery of therapies. Recent advancements in

Roberto Furlan; Chiara Maiorino; Alberto Gatta; Francesca Ruffini; Gianvito Martino

422

Pharmacogenetic studies in multiple myeloma  

Microsoft Academic Search

Multiple myeloma (MM) is a malignant plasma cell disorder that accounts for approximately 10%\\u000aof all hematologic cancers.1-2 MM is characterized by clonal proliferation of malignant plasma\\u000acells in the bone marrow, which secrete a homogeneous immunoglobulin product known as\\u000amonoclonal (M) protein or paraprotein. Typical features of MM include osteolytic bone lesions,\\u000arenal disease, anemia, hypercalcemia and immunodeficiency.3\\u000aThe

S. L. Corthals

2011-01-01

423

Artifactual hypercalcemia in multiple myeloma  

SciTech Connect

A calcium-binding IgG K monoclonal protein in a patient with multiple myeloma and asymptomatic hypercalcemia was recognized, isolated, and characterized. In addition to binding by the whole IgG molecules, calcium was bound by purified Fab fragments and recombined heavy and light chains. In a competitive binding study, the isolated myeloma protein did not bind magnesium. Recognition of calcium-binding myeloma proteins is important in order to avoid therapy for hypercalcemia.

Annesley, T.M.; Burritt, M.F.; Kyle, R.A.

1982-09-01

424

New therapies in multiple myeloma  

Microsoft Academic Search

The melphalan-prednisone regimen has been considered as standard therapy for patients with multiple myeloma (MM) for many\\u000a years. Recently, high-dose chemotherapy with stem-cell support has extended progression-free survival and increased overall\\u000a survival, and it is now considered conventional therapy in younger patients. However, most patients relapse and the salvage\\u000a treatment is not very effective. New active drugs, including immunomodulatory agents,

F. Merchionne; F. Perosa; F. Dammacco

2007-01-01

425

Multiple emulsions for food use  

Microsoft Academic Search

Numerous investigations were done to describe the effects of different food-grade components (e.g. lipid phases, emulsifiers, electrolytes, biopolymers, sugars) on the stability of multiple emulsions (type W\\/O\\/W and O\\/W\\/O). In addition to the emulsion composition, the stability of such systems also depends heavily on the emulsion matrix, influenced by the dispersing methods used. This review highlights recently published results of

Gerald Muschiolik

2007-01-01

426

Polysaccharide gel with multiple emulsion  

Microsoft Academic Search

The aim of the present work was to investigate the possibility of using a semicrystalline oil phase in W\\/O\\/W to modify the release of encapsulated hydrophilic compounds from polysaccharide gels with embedded multiple emulsions.l-Tryptophan was enclosed within the W1-phase of an W1\\/O\\/W2-emulsion, which itself was homogeneously distributed in a Ca2+-alginate gel with maltodextrin (D.E. 6.5) as a bulking agent. Various

Julia Weiss; Inta Scherze; Gerald Muschiolik

2005-01-01

427

Multiple-gate SOI MOSFETs  

Microsoft Academic Search

In an ever increasing need for higher current drive and better short-channel characteristics, silicon-on-insulator MOS transistors are evolving from classical, planar, single-gate devices into three-dimensional devices with multiple gates (double-, triple- or quadruple-gate devices). The evolution and the properties of such devices are described and the emergence of a new class of MOSFETs, called triple-plus (3+)-gate devices offer a practical

Jean-Pierre Colinge

2004-01-01

428

Authentication using multiple communication channels  

Microsoft Academic Search

We discuss an authentication method using multiple communication channels. This method enables on-line service providers to strongly authenticate their users on a non-trusted communication channel (e.g. using a kiosk PC in an Internet café to access the Internet) via trusted communication channels (e.g. a mobile phone network). For the illustration purpose, we use a commonly available configuration in the current

Shintaro Mizuno; Kohji Yamada; Kenji Takahashi

2005-01-01

429

PERSONS WITH MULTIPLE PERSONALITY DISORDER  

Microsoft Academic Search

In the past, Internal Self 1lelpers (ISM) of persons with multiple personality rlisorrler OWPI)) have been deseriberl by rr )7mill Humber of therapists. ii is .studV Iwo\\/ens the base ala I inaton relating to ISHs. Forty respondents who collectively had been therapists fur-rr totrtl of 690 i11P1) patients participated in the snarly. 77re findings of this study suti g ges

M. Ann Adams; Ann Adams; M. N. Sc

1989-01-01

430

The evolution of multiple mating  

PubMed Central

Polyandry is a paradox: why do females mate multiple times when a single ejaculate often provides enough sperm for lifetime egg production? Gowaty et al. addressed explanations for polyandry in Drosophila pseudoobscura from the perspective of hypotheses based on sex differences in costs of reproduction (CoR). Contrary to CoR, Gowaty et al. showed that (1) a single ejaculate was inadequate for lifetime egg production; (2) polyandry provided fitness benefits to females beyond provision of adequate sperm and (3) fitness benefits of polyandry were not offset by costs. Here, I discuss predictions of the ad hoc hypotheses of CoR and three alternative hypotheses to CoR to facilitate a discussion and further development of a strong inference approach to experiments on the adaptive significance of polyandry for females. Each of the hypotheses makes testable predictions; simultaneous tests of the predictions will provide a strong inference approach to understanding the adaptive significance of multiple mating. I describe a sex-symmetric experiment meant to evaluate variation in fitness among lifelong virgins (V); monogamous females and males with one copulation (MOC); monogamous females and males with multiple copulations (MMC); PAND, polyandrous females; and PGYN, polygynous males. Last, I recommend the study of many different species, while taking care in choice of study species and attention to the assumptions of specific hypotheses. I particularly urge the study of many more Drosophila species both in laboratory and the wild to understand the “nature of flies in nature,” where opportunities and constraints mold evolutionary responses.

Gowaty, Patricia Adair

2012-01-01

431

Multiple Forms of Bacterial Hydrogenases  

PubMed Central

Ackrell, B. A. C. (University of Hawaii, Honolulu), R. N. Asato, and H. F. Mower. Multiple forms of bacterial hydrogenases. J. Bacteriol. 92:828–838. 1966.—Extracts of certain bacterial species have been shown by disc electrophoresis on polyacrylamide gel to contain multiple hydrogenase systems. The hydrogenase enzymes comprising these systems have different electrophoretic mobilities and produce a band pattern that is unique for each bacterial species. Of 20 bacterial species known to possess hydrogenase activity and which were examined by this technique, only the activities of Clostridium tetanomorphum and C. thermosaccharolyticum could be attributed, at pH 8.3, to a single hydrogenase enzyme. This multiplicity of hydrogenase forms was found both in bacteria which contain mostly soluble hydrogenases and in those where the hydrogenase is predominantly associated with particulate material. When solubilization of this particulate material could be effected, at least two solubilized hydrogenases were released, and, of these, one would have the same electrophoretic properties (i.e., RF) as one of the soluble hydrogenases already present in small amounts within the cell. Different growth conditions for various types of bacteria, such as the nitrogen source, the degree of aeration, and photosynthetic versus aerobic growth in the dark, as well as the conditions under which the cells were stored, markedly affected the hydrogenase activity of the cells, but not their hydrogenase band pattern. The disc electrophoresis technique proved to be 10 times more sensitive than the manometric technique in detecting hydrogenase activity.

Ackrell, B. A. C.; Asato, R. N.; Mower, H. F.

1966-01-01

432

A multiple armature railgun launcher  

NASA Astrophysics Data System (ADS)

As longer projectiles are accelerated, the efficiency (projectile mass/launch mass) of the launch package decreases. The reduction in efficiency makes launching projectiles with a L/D (length-to-diameter ratio) greater than 20 undesirable. EM guns have several launch characteristics that differ from conventional guns. Higher launch velocities are achievable in EM guns because sonic gas velocities do not limit the projectile velocity. Acceleration profiles for EM guns are more constant. The acceleration forces can be distributed on the projectile easily because the accelerating force can be distributed with multiple armatures. These characteristics combine to make EN guns a very attractive approach for launching very long (i.e.. high L/D ratio) projectiles. Railgun launchers with multiple armatures can distribute the accelerating force. Each armature is supplied gun current for acceleration through its own set of rails. This multi-rail, multi-armature concept was tested at the railgun test facility. The results demonstrated feasibility. We were able to control current distribution to multiple armatures. This paper describes the theory and test results for multi-armature launch of high L/D projectiles.

Heyse, Mark W.; Challita, Antonios; Maas, Brian L.; Bauer, David P.

1993-01-01

433

Trapezium Multiple Systems (Salukvadze, 1978)  

NASA Astrophysics Data System (ADS)

The present catalogue of Trapezium-type Multiple Systems was compiled on the basis of the Index Catalogue of Visual Binary Stars (IDS, Jeffers et al., 1963). At the period of compilation of the Abastumani catalogue, IDS was the most complete catalogue concerning not only stars, but also the data on double stars. Besides giving relative positions, IDS presents the coordinates at 1900 and 2000 epochs, as well as in most cases magnitudes, spectral classes and proper motions. IDS contains all double and multiple stars from the North to the South poles with relative positions published up to the end of 1960, their total number being 64247. In order to select optimum value of K (ratio of the largest to the smallest distances among the components), which is the main criterion for relating a multiple star to the trapezium type, the dependence of the observed trapezia number on the K value has been analysed, and the value 2.6 adopted for it. To exclude optical components, upper limits for the distances of faint components to the main star have been introduced, and the components fainter than 12.5mag were excluded altogether (Salukvadze, 1978). The catalogue of Trapezium-type Multiple Systems contains 412 trapezia, for which, after examining all main spectral catalogues (Jaschek et al., 1964; Kennedy et al., 1974; Houck et al., 1975; Cruz-Gonzales et al., 1974; Lindsey et al., 1968), spectral classes in the MK system have been specified. This was done for 100 systems, including 65 stars of O and B spectral classes. The following data on trapezia are given in the catalogue: positional angles and distances, magnitudes and spectral classes according to HD as well as MK, the ADS and BD identification number of the main star. On the basis of the probability, deduced by Ambartsumian (1954), the number of pseudo-trapezia was estimated, that is, the number of multiple stars, which in fact have no trapezium-type configurations, but are observed as trapezia as a result of their projection on the celestial sphere. The number of estimated pseudo-trapezia is 167. It should be mentioned that among 59 trapezia, the main components of which are of the O-B2 spectral class, there are only 5 pseudo-trapezia. This enables us to maintain that there is a considerable percent of real trapezia among the ones of mentioned spectral classes. Evaluation of the number of optical systems, formed as a result of the appearance of background stars in circles, which are determined by the upper limits of components' distances, led to their insignificant number 9. (1 data file).

Salukvadze, G. N.

1997-02-01

434

Hypodiploid multiple myeloma is characterized by more aggressive molecular markers than non-hyperdiploid multiple myeloma  

PubMed Central

Multiple myeloma can be categorized into hyperdiploid or non-hyperdiploid myeloma based on the number of chromosomes found in the tumor clone. Among the non-hyperdiploid myelomas, the hypodiploid subtype has the most aggressive clinical phenotype, but the genetic differences between groups are not completely defined. In order to understand the genetic background of hypodiploid multiple myeloma better, we compared the genomic (array-based comparative genomic hybridization) and transcriptomic (gene expression profiling) background of 49 patients with hypodiploid myeloma with 50 other non-hyperdiploid and 125 hyperdiploid myeloma patients. There were significant chromosomal and gene expression differences between hyperdiploid patients and non-hyperdiploid and hypodiploid patients. Non-hyperdiploid and hypodiploid patients shared most of the chromosomal abnormalities; nevertheless a subset of these abnormalities, such as monosomies 13, 14 and 22, was markedly increased in hypodiploid patients. Furthermore, deletions of 1p, 12p, 16q and 17p, all associated with poor outcome or progression in multiple myeloma, were significantly enriched in hypodiploid patients. Molecular risk-stratification indices reinforce the worse prognosis associated with hypodiploid multiple myeloma compared with non-hyperdiploid multiple myeloma. Gene expression profiling clustered hypodiploid and non-hyperdiploid subgroups closer than hyperdiploid myeloma but also highlighted the up-regulation of CCND2, WHSC1/MMSET and FGFR3 in the hypodiploid subtype. In summary, hypodiploid multiple myeloma is genetically similar to non-hyperdiploid multiple myeloma but characterized by a higher prevalence of genetic alterations associated with poor outcome and disease progression. It is provocative to hypothesize that hypodiploid multiple myeloma is an advanced stage of non-hyperdiploid multiple myeloma.

Van Wier, Scott; Braggio, Esteban; Baker, Angela; Ahmann, Gregory; Levy, Joan; Carpten, John D.; Fonseca, Rafael

2013-01-01

435

Modeling Multiple Causes of Carcinogenesis  

SciTech Connect

An array of epidemiological results and databases on test animal indicate that risk of cancer and atherosclerosis can be up- or down-regulated by diet through a range of 200%. Other factors contribute incrementally and include the natural terrestrial environment and various human activities that jointly produce complex exposures to endotoxin-producing microorganisms, ionizing radiations, and chemicals. Ordinary personal habits and simple physical irritants have been demonstrated to affect the immune response and risk of disease. There tends to be poor statistical correlation of long-term risk with single agent exposures incurred throughout working careers. However, Agency recommendations for control of hazardous exposures to humans has been substance-specific instead of contextually realistic even though there is consistent evidence for common mechanisms of toxicological and carcinogenic action. That behavior seems to be best explained by molecular stresses from cellular oxygen metabolism and phagocytosis of antigenic invasion as well as breakdown of normal metabolic compounds associated with homeostatic- and injury-related renewal of cells. There is continually mounting evidence that marrow stroma, comprised largely of monocyte-macrophages and fibroblasts, is important to phagocytic and cytokinetic response, but the complex action of the immune process is difficult to infer from first-principle logic or biomarkers of toxic injury. The many diverse database studies all seem to implicate two important processes, i.e., the univalent reduction of molecular oxygen and breakdown of aginuine, an amino acid, by hydrolysis or digestion of protein which is attendant to normal antigen-antibody action. This behavior indicates that protection guidelines and risk coefficients should be context dependent to include reference considerations of the composite action of parameters that mediate oxygen metabolism. A logic of this type permits the realistic common-scale modeling of multiple causes of carcinogenesis and shifts the risk-assessment logic to considerations of ?what dose does?? in contrast to the current process of the substance-specific question of ?what dose is?? Whether reactive oxygen is the proximate or contributing cause of disease or simply a better estimate of biologically effective dose, it has enormous advantages for improved risk- and policy-based decisions. Various estimates of immune system modulation will be given based on radiobiology.

Jones, T.D.

1999-01-24

436

Inflammatory Cortical Demyelination in Early Multiple Sclerosis  

PubMed Central

BACKGROUND Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment. Most studies of cortical lesions have focused on autopsy findings in patients with long-standing, chronic, progressive multiple sclerosis, and the noninflammatory nature of these lesions has been emphasized. Magnetic resonance imaging studies indicate that cortical damage occurs early in the disease. METHODS We evaluated the prevalence and character of demyelinating cortical lesions in patients with multiple sclerosis. Cortical tissues were obtained in passing during biopsy sampling of white-matter lesions. In most cases, biopsy was done with the use of stereotactic procedures to diagnose suspected tumors. Patients with sufficient cortex (138 of 563 patients screened) were evaluated for cortical demyelination. Using immunohistochemistry, we characterized cortical lesions with respect to demyelinating activity, inflammatory infiltrates, the presence of meningeal inflammation, and a topographic association between cortical demyelination and meningeal inflammation. Diagnoses were ascertained in a subgroup of 77 patients (56%) at the last follow-up visit (at a median of 3.5 years). RESULTS Cortical demyelination was present in 53 patients (38%) (104 lesions and 222 tissue blocks) and was absent in 85 patients (121 tissue blocks). Twenty-five patients with cortical demyelination had definite multiple sclerosis (81% of 31 patients who underwent long-term follow-up), as did 33 patients without cortical demyelination (72% of 46 patients who underwent long-term follow-up). In representative tissues, 58 of 71 lesions (82%) showed CD3+ T-cell infiltrates, and 32 of 78 lesions (41%) showed macrophage-associated demyelination. Meningeal inflammation was topographically associated with cortical demyelination in patients who had sufficient meningeal tissue for study. CONCLUSIONS In this cohort of patients with early-stage multiple sclerosis, cortical demyelinating lesions were frequent, inflammatory, and strongly associated with meningeal inflammation. (Funded by the National Multiple Sclerosis Society and the National Institutes of Health.)

Lucchinetti, Claudia F.; Popescu, Bogdan F.G.; Bunyan, Reem F.; Moll, Natalia M.; Roemer, Shanu F.; Lassmann, Hans; Bruck, Wolfgang; Parisi, Joseph E.; Scheithauer, Bernd W.; Giannini, Caterina; Weigand, Stephen D.; Mandrekar, Jay; Ransohoff, Richard M.

2012-01-01

437

Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans.  

PubMed

We have performed a meta-analysis of the major-histocompatibility-complex (MHC) region in systemic lupus erythematosus (SLE) to determine the association with both SNPs and classical human-leukocyte-antigen (HLA) alleles. More specifically, we combined results from six studies and well-known out-of-study control data sets, providing us with 3,701 independent SLE cases and 12,110 independent controls of European ancestry. This study used genotypes for 7,199 SNPs within the MHC region and for classical HLA alleles (typed and imputed). Our results from conditional analysis and model choice with the use of the Bayesian information criterion show that the best model for SLE association includes both classical loci (HLA-DRB1(?)03:01, HLA-DRB1(?)08:01, and HLA-DQA1(?)01:02) and two SNPs, rs8192591 (in class III and upstream of NOTCH4) and rs2246618 (MICB in class I). Our approach was to perform a stepwise search from multiple baseline models deduced from a priori evidence on HLA-DRB1 lupus-associated alleles, a stepwise regression on SNPs alone, and a stepwise regression on HLA alleles. With this approach, we were able to identify a model that was an overwhelmingly better fit to the data than one identified by simple stepwise regression either on SNPs alone (Bayes factor [BF] > 50) or on classical HLA alleles alone (BF > 1,000). PMID:23084292

Morris, David L; Taylor, Kimberly E; Fernando, Michelle M A; Nititham, Joanne; Alarcón-Riquelme, Marta E; Barcellos, Lisa F; Behrens, Timothy W; Cotsapas, Chris; Gaffney, Patrick M; Graham, Robert R; Pons-Estel, Bernardo A; Gregersen, Peter K; Harley, John B; Hauser, Stephen L; Hom, Geoffrey; Langefeld, Carl D; Noble, Janelle A; Rioux, John D; Seldin, Michael F; Criswell, Lindsey A; Vyse, Timothy J

2012-10-18

438

46 CFR 183.322 - Multiple generators.  

Code of Federal Regulations, 2012 CFR

... 2012-10-01 false Multiple generators. 183.322 Section 183.322 ...Distribution Systems § 183.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2012-10-01

439

46 CFR 120.322 - Multiple generators.  

Code of Federal Regulations, 2012 CFR

... 2012-10-01 false Multiple generators. 120.322 Section 120.322 ...Distribution Systems § 120.322 Multiple generators. When a vessel is equipped with two or more generators to supply ship's service...

2012-10-01

440

Can Multiple Myeloma Be Found Early?  

MedlinePLUS

... Myeloma + - Text Size Download Printable Version [PDF] » Early Detection, Diagnosis, and Staging TOPICS Document Topics GO » SEE ... Multiple Myeloma? Causes, Risk Factors, and Prevention Early Detection, Diagnosis, and Staging Treating Multiple Myeloma Talking With ...

441

Multiple Sclerosis: Can It Cause Seizures?  

MedlinePLUS

Multiple sclerosis Basics In-Depth Multimedia Expert Answers Resources Reprints A single copy of this article may be reprinted for personal, noncommercial use only. Multiple sclerosis: Can it cause seizures? By Mayo Clinic staff ...

442

14 CFR 1261.505 - Multiple debts.  

Code of Federal Regulations, 2013 CFR

... false Multiple debts. 1261.505 ...Aeronautics and Space NATIONAL AERONAUTICS AND...505 Multiple debts. When collecting...NASA will apply the recovered amounts to those debts in accordance with the best interests...

2013-01-01

443

14 CFR 1261.505 - Multiple debts.  

Code of Federal Regulations, 2012 CFR

... false Multiple debts. 1261.505 ...Aeronautics and Space NATIONAL AERONAUTICS AND...505 Multiple debts. When collecting...NASA will apply the recovered amounts to those debts in accordance with the best interests...

2012-01-01

444

All About Multiplication Exploring Equal Sets  

NSDL National Science Digital Library

Students explore the set model for multiplication. They find products using equal sets and present their results in a table. Next students apply their knowledge about multiplication in the creation of pictographs.

Math, Illuminations N.

2009-03-17

445

The Multiple Control of Verbal Behavior  

PubMed Central

Amid the novel terms and original analyses in Skinner's Verbal Behavior, the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms convergent multiple control and divergent multiple control. We point out some implications for applied work and discuss examples of the role of multiple control in humor, poetry, problem solving, and recall. Joint control and conditional discrimination are discussed as special cases of multiple control. We suggest that multiple control is a useful analytic tool for interpreting virtually all complex behavior, and we consider the concepts of derived relations and naming as cases in point.

Michael, Jack; Palmer, David C; Sundberg, Mark L

2011-01-01

446

42 CFR 102.45 - Multiple survivors.  

Code of Federal Regulations, 2011 CFR

...PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request...Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...

2011-10-01

447

42 CFR 102.45 - Multiple survivors.  

Code of Federal Regulations, 2012 CFR

...PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES SMALLPOX COMPENSATION PROGRAM Procedures for Filing Request...Multiple survivors. Multiple survivors of the same smallpox vaccine recipient or vaccinia contact may file Request Forms...

2012-10-01

448

Multiple-Fold Clustered Processor Mesh Array.  

National Technical Information Service (NTIS)

The multiple-fold clustered processor mesh array is a triangular organization of clustered processing elements. This multiple-fold array maintains functional equivalence to the nearest neighbor mesh computer with uni-directional interprocessor communicati...

G. G. Pechanek S. Vassiliadis J. G. Delgado

1993-01-01

449

Floor Acquisition Multiple Access with Collision Resolution.  

National Technical Information Service (NTIS)

Collision avoidance and resolution multiple access (CARMA) protocols are presented and analyzed. These protocols use a floor acquisition multiple access (FAMA) strategy based on carrier sensing, together with collision resolution of floor requests (RTS) b...

J. J. Garcia-Luna-Aceves R. Garces

1996-01-01

450

Multiple station thermal diffusivity instrument  

SciTech Connect

A multiple furnace laser flash thermal diffusivity system has been developed. The system is equipped with a movable Nd:Glass laser unit, two IR detectors and furnaces for precise measurements of thermal diffusivity over the temperature range from {minus}150{degree}C to 2500{degree}C. All furnaces can operate in vacuum and inert gas; the environmental effects furnace also supports oxidizing and reducing environments. To increase testing speed the graphite and aluminum furnaces are both equipped with six-sample carousels. Thermal diffusivity measurements of three standard reference materials show excellent results over the entire temperature range.

Wang, H.; Dinwiddie, R.B. [Oak Ridge National Lab., TN (United States); Gaal, P.S. [Anter Corp., Pittsburgh (United States)

1995-12-31

451

Recirculation in multiple wave conversions  

SciTech Connect

A one-dimensional multiple wave-conversion model is constructed that allows energy recirculation in ray phase space. Using a modular eikonal approach, the connection coefficients for this model are calculated by ray phase-space methods. Analytical results (confirmed numerically) show that all connection coefficients exhibit interference effects that depend on an interference phase, calculated from the coupling constants and the area enclosed by the intersecting rays. This conceptual model, which focuses on the topology of intersecting rays in phase space, is used to investigate how mode conversion between primary and secondary waves is modified by the presence of a tertiary wave.

Brizard, A. J. [Department of Chemistry and Physics, Saint Michael's College, Colchester, Vermont 05439 (United States); Kaufman, A. N. [Department of Physics and Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720 (United States); Tracy, E. R. [Department of Physics, College of William and Mary, Williamsburg, Virginia 23187-8795 (United States)

2008-08-15

452

Multiple intracranial dural arteriovenous fistula  

PubMed Central

Dural arteriovenous fistula (DAVF) is also known as dural arteriovenous malformation. Two forms of DAVF have been introduced, however, here we present an exceptional case of DAVF with unique origin and drainage. In this study, we present a rare case of multiple DAVFs in a 50 year old man with right parietal intraparenchymal hemorrhage. MRI showed two round right parieto-occipital masses with flow void intensity adjacent to superior sagittal sinus (SSS). Another pathology connected to SSS by an abnormal cortical vein was detected anterior to first lesion. This study showed that both DAVFs were simultaneously drained in SSS in our patient.

Rahmanian, Abdolkarim; Farrokhi, Majid R.; Alibai, Ehsan A.; Masoudi, Mohammad S.

2013-01-01

453

Painful and involuntary Multiple Sclerosis  

PubMed Central

Importance of the field Pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions may occur in patients with multiple sclerosis (MS). Areas covered in the field In the present review we attempt to summarize the current knowledge on the impact that pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions have in patients with MS. What the reader will gain The current understanding on pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions and future research perspectives to expand the knowledge of this field. Take home message To effectively manage MS it is essential that these symptoms are recognised as early as possible and treated by a rehabilitative multidisciplinary approach, based on proven scientific evidence.

Bagnato, Francesca; Centonze, Diego; Galgani, Simonetta; Grasso, Maria Grazia; Haggiag, Shalom; Strano, Stefano

2010-01-01

454

Multiple channel programmable coincidence counter  

DOEpatents

A programmable digital coincidence counter having multiple channels and featuring minimal dead time. Neutron detectors supply electrical pulses to a synchronizing circuit which in turn inputs derandomized pulses to an adding circuit. A random access memory circuit connected as a programmable length shift register receives and shifts the sum of the pulses, and outputs to a serializer. A counter is input by the adding circuit and downcounted by the serializer, one pulse at a time. The decoded contents of the counter after each decrement is output to scalers.

Arnone, G.J.

1989-02-27

455

Combination therapy in multiple sclerosis.  

PubMed

Over the past decade, multiple sclerosis (MS) has become a treatable neurologic illness. However, given the rather modest benefit of the currently available disease-modifying agents, as well as the challenges associated with performing placebo-controlled, equivalence, and superiority trials, the logic of combining therapies in MS has considerable appeal. Selecting agents for combination requires careful consideration, as the immunomodulating activity of one drug could potentially interfere with the therapeutic effect of another, and certain combinations may be associated with unforeseen adverse effects. Rigorously controlled studies are needed to determine the safest and most effective use of new and existing MS therapies. PMID:15865891

Tullman, Mark J; Lublin, Fred D

2005-05-01

456

Estrogen Treatment in Multiple Sclerosis  

PubMed Central

Currently available treatments for multiple sclerosis reduce inflammatory lesions on MRI and decrease clinical relapses but have limited effects on disability. Novel treatment options that target both the inflammatory as well as the neurodegenerative component of the disease are therefore needed. A growing body of evidence from basic science and clinical studies supports the therapeutic potential of estrogens in MS. Mechanisms of action include both immunomodulatory and directly neuroprotective pathways. A first pilot trial of oral estriol treatment showed encouraging results. There are now several phase II trials underway to further determine the efficacy of estrogen treatment in MS.

Gold, Stefan M; Voskuhl, Rhonda R

2009-01-01

457

Recirculation in multiple wave conversions  

SciTech Connect

A one-dimensional multiple wave-conversion model is constructed that allows energy recirculation in ray phase space. Using a modular eikonal approach, the connection coefficients for this model are calculated by ray phase-space methods. Analytical results (confirmed numerically) show that all connection coefficients exhibit interference effects that depend on an interference phase, calculated from the coupling constants and the area enclosed by the intersecting rays. This conceptual model, which focuses on the topology of intersecting rays in phase space, is used to investigate how mode conversion between primary and secondary waves is modified by the presence of a tertiary wave.

Kaufman, A. N.; Brizard, A.J.; Kaufman, A.N.; Tracy, E.R.

2008-07-30

458

Multiple intracranial dural arteriovenous fistula.  

PubMed

Dural arteriovenous fistula (DAVF) is also known as dural arteriovenous malformation. Two forms of DAVF have been introduced, however, here we present an exceptional case of DAVF with unique origin and drainage. In this study, we present a rare case of multiple DAVFs in a 50 year old man with right parietal intraparenchymal hemorrhage. MRI showed two round right parieto-occipital masses with flow void intensity adjacent to superior sagittal sinus (SSS). Another pathology connected to SSS by an abnormal cortical vein was detected anterior to first lesion. This study showed that both DAVFs were simultaneously drained in SSS in our patient. PMID:24124437

Rahmanian, Abdolkarim; Farrokhi, Majid R; Alibai, Ehsan A; Masoudi, Mohammad S

2013-04-01

459

Double [sigma]-multiplicative matrices  

NASA Astrophysics Data System (ADS)

The class of [sigma]-regular matrices was defined and characterized by Schaefer [P. Schaefer, Infinite matrices and invariant means, Proc. Amer. Math. Soc. 36 (1972) 104-110] and further studied by Mursaleen [Mursaleen, On some new invariant matrix methods of summability, Quart. J. Math. Oxford 34 (1983) 77-86], Ahmad and Mursaleen [Z.U. Ahmad, Mursaleen, An application of Banach limits, Proc. Amer. Math. Soc. 103 (1988) 244-246]. In this paper we characterize four-dimensional [sigma]-multiplicative matrices, and establish a core theorem.

Mursaleen; Mohiuddine, S. A.

2007-03-01

460

Smart card multiple function badge  

SciTech Connect

Smart cards are credit card-sized computers with integrated data storage, an operating system to manage the data, and built-in security features that protect the data. They are used to distribute information to remote sites, providing the same or greater reliability, data integrity, and information security than a network system. However, smart cards may provide greater functionality at a lower cost than network systems. The US Department of Energy Hanford Site is developing the smart card to be used as a multiple function identification badge that will service various data management requirements on the Site. This paper discusses smart card technology and the proposed Hanford Site applications.

Nelson, R.A.

1993-06-01

461

Montgomery Multiplication in GF(2k)  

Microsoft Academic Search

We show that the multiplication operation c=a · b · r-1 in the field GF(2k can be implemented significantly faster in software than the standard multiplication, where r is a special fixed element of the field. This operation is the finite field analogue of the Montgomery multiplication for modular multiplication of integers. We give the bit-level and word-level algorithms for

Cetin K. Koc; Tolga Acar

1998-01-01

462

Multiple-Valued Logic Design Tools  

Microsoft Academic Search

A brief overview of past progress in multiple-valued logic design is presented. The methods are considered with respect to the likely development of multiple-valued field programmable gate arrays. Look-up table based arrays are considered in some detail and an algorithm for mapping multiple-valued functions to such an array is presented. This algorithm uses reduced order multiple-valued decision diagrams, an extension

D. Michael Miller

1993-01-01

463

Deconstructing Calculation Methods, Part 3: Multiplication  

ERIC Educational Resources Information Center

|In this third of a series of four articles, the author deconstructs the primary national strategy's approach to written multiplication. The approach to multiplication, as set out on pages 12 to 15 of the primary national strategy's "Guidance paper" "Calculation" (DfES, 2007), is divided into six stages: (1) mental multiplication using…

Thompson, Ian

2008-01-01

464

Multiple Literacies and Middle School Students  

ERIC Educational Resources Information Center

|Multiple literacies, multiple ways to look at the world, impact how students make connections to and understand their world. Referring to students' reading of their world using the term multiple literacies validates that students actually add knowledge to the academic conversation. Referring to the wealth of knowledge students bring as only…

Perry, Tonya B.

2006-01-01

465

Multiple Literacies, New Literacies, and Teacher Education  

ERIC Educational Resources Information Center

|The authors consider the role that multiple literacies and new literacies might play in shaping preservice education. They review existing literature on multiple and new literacies in preservice education and examine in-school and out-of-school enactments of new and multiple literacies to answer the question, What can we do in preservice teacher…

Cervetti, Gina; Damico, James; Pearson, P. David

2006-01-01

466

Functional Multiple-Set Canonical Correlation Analysis  

ERIC Educational Resources Information Center

|We propose functional multiple-set canonical correlation analysis for exploring associations among multiple sets of functions. The proposed method includes functional canonical correlation analysis as a special case when only two sets of functions are considered. As in classical multiple-set canonical correlation analysis, computationally, the…

Hwang, Heungsun; Jung, Kwanghee; Takane, Yoshio; Woodward, Todd S.

2012-01-01

467

The Multiple Control of Verbal Behavior  

ERIC Educational Resources Information Center

|Amid the novel terms and original analyses in Skinner's "Verbal Behavior", the importance of his discussion of multiple control is easily missed, but multiple control of verbal responses is the rule rather than the exception. In this paper we summarize and illustrate Skinner's analysis of multiple control and introduce the terms "convergent…

Michael, Jack; Palmer, David C.; Sundberg, Mark L.

2011-01-01

468

Clinical characteristics of cortical multiple sclerosis  

Microsoft Academic Search

There are several articles in this special issue in which authors eloquently describe neurobehavioural and cognitive complications of multiple sclerosis with relevant neuropsychological assessments and neuroimaging findings. However behavioural and cognitive presentation of multiple sclerosis remains poorly understood. Two years ago, we reported a series of patients with multiple sclerosis who presented with neurobehavioural symptoms and had neuropsychological deficits consistent

Mojtaba Zarei

2006-01-01

469

A multigenerational family with multiple sclerosis  

Microsoft Academic Search

Summary We report a family with 15 individuals affected with multiple sclerosis present in three and possibly four generations. The segregation of multiple sclerosis within this pedigree is consistent with an autosomal dominant mode of inheritance with reduced penetrance. The clinical characteristics of the affected individuals are indistinguishable from those seen in sporadic multiple sclerosis with respect to sex ratio,

D. A. Dyment; M. Z. Cader; C. J. Willer; N. Risch; A. D. Sadovnick; G. C. Ebers

2002-01-01

470

Hydraulic fracture with multiple segments II. Modeling  

Microsoft Academic Search

It is now well recognized that multiple fracturing, hydraulic fracture (HF) process zone, fracture width vs. height, and net-pressure calibration procedures are inter-related critical issues that need to be studied for making significant improvements in HF treatment design. To the best of our knowledge, there are no systematic studies of multiple HFs. Multiple fractures can occur as a result of

Leonid N. Germanovich; Lev M. Ring; Dmitriy K. Astakhov; Jacob Shlyapobersky; Michael J. Mayerhofer

1997-01-01

471

Age at disability milestones in multiple sclerosis  

Microsoft Academic Search

Many efforts have been devoted to the description of the prognosis of multiple sclerosis and its possible influential factors in terms of time to reach disability milestones. By contrast, the age at which patients with multiple sclerosis reach these milestones has not yet stirred much interest. We have tested the hypothesis whether the prognosis of multiple sclerosis depends on the

Christian Confavreux; Sandra Vukusic

2006-01-01

472

The Many Meanings of "Multiple Measures"  

ERIC Educational Resources Information Center

|Professional assessment organizations almost universally endorse the use of multiple measures for making education decisions. In practice, however, the concept of multiple measures is defined and applied in many different ways, depending on how we answer two questions--What counts as a "measure"? and How are the multiple measures combined?…

Brookhart, Susan M.

2009-01-01

473

Multiple Sclerosis, Schizophrenia, Temperature and Latitude  

Microsoft Academic Search

Greater geographical latitude was found to be positively associated with multiple sclerosis rates in the United States and Italy. Latitude was found to be positively correlated with schizophrenia rates in Italy. Temperature was negatively correlated with multiple sclerosis in the United States. The exploratory variable of amount of sunlight was inversely related to multiple sclerosis in the United States and

Donald I. Templer; Brent Hughey; Hilda Chalgujian; Michael Lavoie; Neal H. Trent; Paul Sahwell; Dorothy A. Spencer

474

Functional Multiple-Set Canonical Correlation Analysis  

ERIC Educational Resources Information Center

We propose functional multiple-set canonical correlation analysis for exploring associations among multiple sets of functions. The proposed method includes functional canonical correlation analysis as a special case when only two sets of functions are considered. As in classical multiple-set canonical correlation analysis, computationally, the…

Hwang, Heungsun; Jung, Kwanghee; Takane, Yoshio; Woodward, Todd S.

2012-01-01

475

Formulation of shear rate sensitive multiple emulsions  

Microsoft Academic Search

This work mainly concentrates on the formulation of W\\/O\\/W multiple emulsions capable of breaking and releasing their inner aqueous phase under shear rates compatible with agroalimentary, pharmaceutical and cosmetic applications. Three kinds of multiple emulsions were studied: one with a high concentration of primary emulsion, not viscosified in the external aqueous phase; multiple emulsions gelified with a synthetic polymer (Carbopol

V Muguet; M Seiller; G Barratt; O Ozer; J. P Marty; J. L Grossiord

2001-01-01

476

Superclusters and hadronic multiplicity distributions  

SciTech Connect

The multiplicity distribution is expressed in terms of supercluster production in hadronic processes at high energy. This process creates unstable clusters at intermediate stages and hadrons in final stage. It includes Poisson-transform distributions (with the partially coherent distribution as a special case) and is very flexible for phenomenological analyses. The associated Koba, Nielson, and Olesen limit and the behavior of cumulant moments are analyzed in detail for finite and/or infinite cluster size and particle size per cluster. In general, a supercluster distribution does not need to be equivalent to a negative binomial distribution to fit experimental data well. Furthermore, the requirement of such equivalence leads to many solutions, in which the average size of the cluster is not logarithmic: e.g., it may show a power behavior instead. Superclustering is defined as a two-or multi-stage process underlying observed global multiplicity distributions. At the first stage of the production process, individual clusters are produced according to a given statistical law. For example, the clustering distribution may be described by partially coherent (oreven sub-Poissonian distribution models. At the second stage, the clusters are considered as the sources of particle production. The corresponding distribution may then be as general as the clustering distribution just mentioned. 8 refs.

Shih, C.C.; Carruthers, P.

1986-01-01

477

Multiple channel data acquisition system  

DOEpatents

A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler. 25 figs.

Crawley, H.B.; Rosenberg, E.I.; Meyer, W.T.; Gorbics, M.S.; Thomas, W.D.; McKay, R.L.; Homer, J.F. Jr.

1990-05-22

478

Multiple channel data acquisition system  

DOEpatents

A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler.

Crawley, H. Bert (Ames, IA); Rosenberg, Eli I. (Ames, IA); Meyer, W. Thomas (Ames, IA); Gorbics, Mark S. (Ames, IA); Thomas, William D. (Boone, IA); McKay, Roy L. (Ames, IA); Homer, Jr., John F. (Ames, IA)

1990-05-22

479

Multiple protocol fluorometer and method  

DOEpatents

A multiple protocol fluorometer measures photosynthetic parameters of phytoplankton and higher plants using actively stimulated fluorescence protocols. The measured parameters include spectrally-resolved functional and optical absorption cross sections of PSII, extent of energy transfer between reaction centers of PSII, F.sub.0 (minimal), F.sub.m (maximal) and F.sub.v (variable) components of PSII fluorescence, photochemical and non-photochemical quenching, size of the plastoquinone (PQ) pool, and the kinetics of electron transport between Q.sub.a and PQ pool and between PQ pool and PSI. The multiple protocol fluorometer, in one embodiment, is equipped with an excitation source having a controlled spectral output range between 420 nm and 555 nm and capable of generating flashlets having a duration of 0.125-32 .mu.s, an interval between 0.5 .mu.s and 2 seconds, and peak optical power of up to 2 W/cm.sup.2. The excitation source is also capable of generating, simultaneous with the flashlets, a controlled continuous, background illumination.

Kolber, Zbigniew S. (Shoreham, NY); Falkowski, Paul G. (Stony Brook, NY)

2000-09-19

480

Developmental thermography: multiple aspect thermography  

NASA Astrophysics Data System (ADS)

Multiple aspect thermography (MAT) is a kind of developmental thermography. MAT was designed in order to supplement the shortage of the number of coverage aspects in triple aspect thermography (TAT). TAT allows simultaneous display of numbers of thermograms on various selected aspects of the subject in CRT frame. This paper reports on MAT methodology and discusses some aspects of the problems and the special points of this technique. The data on the thermal images on the entire subject can be recorded in one revolution of the subject. After the measurement is completed all over the subject, thermograms of any selected aspects is composed in a CRT frame in multiple image arrangement by recalling the recorded thermal data using the multi-video processor. Strictly speaking, based on the thermography on the moving target in MAT, distortion and smoothing of the thermal pattern in MAT are essentially unavoidable. The shorter the frame time of the thermocamera is, the less the problems in MAT can be reduced. However, the problems in MAT are negligible under the usual condition for clinical application of MAT.

Nagasawa, Akinori; Katoh, Kazuichi

1993-09-01

481

Multiple sclerosis and sexual dysfunction  

PubMed Central

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system characterized by episodic and progressive neurologic dysfunction resulting from inflammatory and autoimmune reactions. The underlying pathogenesis of MS remains largely unclear. However, it is currently accepted as a T cell-mediated autoimmune disease. Among other clinical manifestations, sexual dysfunction (SD) is a painful but still underreported and underdiagnosed symptom of the disorder. SD in MS patients may result from a complex set of conditions and may be associated with multiple anatomic, physiologic, biologic, medical and psychological factors. SD arises primarily from lesions affecting the neural pathways involved in physiologic function. In addition, psychological factors, the side effects of medications and physical symptoms such as fatigue, muscular weakness, menstrual changes, pain and concerns about bladder and bowel incontinence may also be involved. Since MS primarily affects young people, SD secondary to MS may have a great impact on quality of life. Thus, maintaining a healthy sexual life with MS is an important priority. The treatment of SD requires multidisciplinary teamwork and cooperation among specialists, individual patients, partners and the society.

Guo, Zhen-Ni; He, Si-Yuan; Zhang, Hong-Liang; Wu, Jiang; Yang, Yi

2012-01-01

482

Multiple endocrine neoplasia type 1.  

PubMed

Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumors. Some patients may also develop carcinoid tumors, adrenocortical tumors, facial angiofibromas, collagenomas, and lipomas. MEN1 is an autosomal-dominant disorder, due to mutations in the tumor suppressor gene MEN1, which encodes a 610 amino acid protein, menin. Thus, the finding of MEN1 in a patient has important implications for family members because first-degree relatives have a 50% risk of developing the disease and can often be identified by MEN1 mutational analysis. Patients with MEN1 have a decreased life-expectancy and the outcomes of current treatments, which are generally similar to that for the respective tumors occurring in non-MEN1 patients, are not as successful because of multiple tumors, which may be larger, more aggressive, and resistant to treatment, and the concurrence of metastases. The prognosis for MEN1 patients might be improved by pre-symptomatic tumor detection and undertaking treatment specific for MEN1-tumors. Thus, it is recommended that MEN1 patients and their families should be cared for by multi-disciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors. PMID:23565397

Thakker, R V

2012-12-01

483

Multiple endocrine neoplasia type 1.  

PubMed

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant tumor syndrome characterized by the occurrence of tumors in multiple endocrine tissues and nonendocrine tissues. The three main endocrine tissues most frequently affected by tumors are parathyroid (95%), enteropancreatic neuroendocrine (50%) and anterior pituitary (40%). Tumors are caused by a heterozygous germline-inactivating mutation in the MEN1 gene (1st hit) followed by somatic inactivating mutation or loss of the normal copy of the gene (2nd hit), leading to complete loss of function of the encoded protein menin. Most of the disease features and tumors are recapitulated in mouse models with heterozygous germline loss of the Men1 gene. Also, tissue-specific tumors are observed in mouse models with homozygous somatic loss of the Men1 gene specifically in MEN1-associated endocrine tissues. Hence, mouse models could serve as possible surrogates for studying MEN1 and related states. To gain insights into MEN1 pathophysiology, menin-interacting partners and pathways have been identified to investigate its tumor suppressor and other functions. Also, the 3D crystal structure of menin has been deciphered which could be useful to reveal the relevance of MEN1 gene mutations and menin's interactions. This chapter covers clinical, genetic and basic findings about the MEN1 syndrome, MEN1 gene and its product protein menin. PMID:23652667

Agarwal, Sunita K

2013-03-19

484

Multiple endocrine neoplasia type 1  

PubMed Central

Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumors. Some patients may also develop carcinoid tumors, adrenocortical tumors, facial angiofibromas, collagenomas, and lipomas. MEN1 is an autosomal-dominant disorder, due to mutations in the tumor suppressor gene MEN1, which encodes a 610 amino acid protein, menin. Thus, the finding of MEN1 in a patient has important implications for family members because first-degree relatives have a 50% risk of developing the disease and can often be identified by MEN1 mutational analysis. Patients with MEN1 have a decreased life-expectancy and the outcomes of current treatments, which are generally similar to that for the respective tumors occurring in non-MEN1 patients, are not as successful because of multiple tumors, which may be larger, more aggressive, and resistant to treatment, and the concurrence of metastases. The prognosis for MEN1 patients might be improved by pre-symptomatic tumor detection and undertaking treatment specific for MEN1-tumors. Thus, it is recommended that MEN1 patients and their families should be cared for by multi-disciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors.

Thakker, R. V.

2012-01-01

485

Acquired Dysfibrinogenemia Secondary to Multiple Myeloma  

Microsoft Academic Search

Abnormal coagulation properties indicative of a dysfibrinogen were found in the plasma of a 72-year-old male with multiple myeloma (IgG?, stage IIIA). The patient had high paraprotein concentration (85.75 g\\/l) and prolonged thrombin time (76.8 s), activated partial thromboplastin time (39.5 s), prothrombin time (23.5 s) and reptilase time (72.0 s). The fibrinogen level was increased. The fibrin polymerization induced

Roman Kotlín; Tomáš Riedel; Peter Salaj; Zuzana Reicheltová; Pavel Májek; Tarek Khaznadar; Jan E. Dyr

2008-01-01

486

Possible Evidence for Enhanced Seasonality During the Little Ice Age Indicated by Multiple Isotopes from Kepler Lake, South-Central Alaska  

NASA Astrophysics Data System (ADS)

We present multiple-proxy data from two short cores (85 cm and 101 cm) from Kepler Lake, an evaporation- insensitive, groundwater-fed marl lake in South-Central Alaska to reconstruct climate and environmental changes in the recent centuries. The proxies used include calcite C and O isotopes, organic matter (OM) C and N isotopes, and loss on ignition (LOI) analysis. Two cores can be visually correlated based upon LOI results. A 600 year chronology was established based on 3 calibrated AMS 14C dates of terrestrial macrofossils and 210Pb analysis. ?18OVPDB values of inorganic calcite range from - 17.0‰ to -15.7‰, with the highest values between 1470 and 1840 AD during the Little Ice Age (LIA). The relatively high ?18O values during the cold LIA contrast with the conventional temperature interpretation of O isotopes. Therefore, the isotopic shifts around the LIA were likely caused by a shift in atmospheric circulation. A weakening of the wintertime Aleutian Low pressure system residing over the Gulf of Alaska would result in enriched 18O in precipitation as well as a colder winter climate in SC Alaska. During the LIA period CaCO3 contents were elevated by ~15% to >80%. Calcite precipitation in freshwater lakes is primarily a function of summer temperature; we propose that the LIA in SC Alaska represents a period of colder winters and warmer summers. This interpretation is also supported by C isotopes, reflecting aquatic productivity. Both ?13C OM and ?13Ccalcite (relative to VPDB) exhibit relatively high values at 1600 to 1840 AD, after which ?13COM remains constant throughout the rest of the record and ?13Ccalcite declines after the LIA. The delayed increase in ?13C of OM and calcites at 1600 AD may reflect the differential responses of calcite precipitation and aquatic productivity. The negative shift of ~1‰ in ?18O in the 1840s has also been documented in ice cores from Mt. Logan and in marl lake sediments from the southern Yukon, suggesting a broad-scale shift in atmospheric circulation at the end of the LIA. The enhanced seasonality during the LIA may explain some complex moisture and temperature changes as observed from glaciers, lakes and tree-ring records in the region. We speculate that these shifts during and after the LIA may be basin-wide events in the Pacific Ocean.

Gonyo, A.; Yu, Z.; Bebout, G.

2008-12-01

487

Combination therapy in multiple sclerosis.  

PubMed

The multifaceted pathogenesis of multiple sclerosis (MS) involves complex interactions between the immune and the central nervous systems which provide a multitude of targets for therapeutic interventions. Current therapies for MS are only partially effective. One potential strategy to increase treatment efficacy is the combination of two or more drugs with complementary mechanisms of action, which may result in additive or synergistic therapeutic effects. In this review, we discuss the rationale and requirements and review the evidence for combination therapy in MS from in-vitro experiments, animal studies and clinical trials. Encouraging experience to date and further well-designed clinical trials with combination therapy may lead to the implementation of specific combinations of drugs in the treatment of MS. PMID:21111490

Milo, Ron; Panitch, Hillel

2010-12-15

488

Genetic heterogeneity of multiple exostoses  

SciTech Connect

Hereditary multiple exostoses (EXT, MIM 133700) is an autosomal dominant bony disorder characterized by the formation of cartilage-capped juxta-epiphyseal prominences on the long bones. Three disease genes, mapping to chromosomes 8q24 and 11 have been recently localized, supporting genetic heterogeneity of this condition. We have refined the genetic mapping of the chromosome 19p locus using a series of six families unlinked to chromosomes 8 or 11. Several genes expressed during cartilage growth and located in this region have been tested as candidate genes, namely zinc finger proteins, protein kinases, JunD and JunB. Hitherto no major rearrangement of these genes has been detected in EXT families linked to chromosome 19p.

Legeai-Mallet, L.; Munnich, A.; Le Merrer, M. [Inserm U393 Hopital des Enfants-Malades, Paris (France)] [and others

1994-09-01

489

Congenital Abnormalities and Multiple Sclerosis  

PubMed Central

Background There is a strong maternal parent-of-origin effect in determining susceptibility to multiple sclerosis (MS). One hypothesis is that an abnormal intrauterine milieu leading to impaired fetal development could plausibly also result in increased susceptibility to MS. A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly. Methods We investigated whether or not congenital anomalies are associated with MS in a population-based cohort. We identified 7063 MS index cases and 2655 spousal controls with congenital anomaly information from the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). Results The frequency of congential anomalies were compared between index cases and controls. No significant differences were found. Conclusions Congenital anomalies thus do not appear to be associated with MS. However, we did not have complete data on types and severity of congenital anomalies or on maternal birth history and thus this study should be regarded as preliminary.

2010-01-01

490

Natalizumab therapy for multiple sclerosis.  

PubMed

Natalizumab is a monoclonal therapeutic antibody that inhibits migration of lymphocytes into the central nervous system (CNS) by blocking integrins. Several clinical trials have shown an excellent efficacy in the treatment of relapsing remitting multiple sclerosis. This efficacy is also underlined by postmarketing data of patients with a more aggressive disease compared with the clinical trials. Certain patients might even improve during natalizumab treatment. These positive effects have to be balanced against potential adverse events. In this respect, allergic reactions, hematologic abnormalities, melanoma, lymphoma, infections, and most importantly, progressive multifocal leukoencephalopathy (PML) are discussed. A special emphasis is put on the risk stratification algorithm for PML and approaches for PML treatment. Further, patient and disease characteristics are discussed that might prompt the start or cessation of natalizumab. Finally, data on how to continue after stopping natalizumab are summarized. PMID:23709210

Derfuss, Tobias; Kuhle, Jens; Lindberg, Raija; Kappos, Ludwig

2013-05-25

491

Multiple sclerosis: pregnancy and motherhood.  

PubMed

Although at any time in the UK there are about 20,000 women with multiple sclerosis (MS) who may be considering having children, very little is known about their experiences or about those who have had children after the onset of disease. Using semi structured interviews, we explored the childbearing experiences of nine women with MS in order to better understand their expectations, needs and concerns associated with pregnancy, childbirth and mothering. A major concern for women with MS was theirs and their babies' health and future wellbeing, especially how pregnancy can impact their long term MS prognosis and how the condition would affect their ability to look after the baby. In conclusion we suggest that midwives with special interests in MS could be a key source of information and ongoing support. PMID:23914679

Anderson, Joanna; Wallace, Louise

2013-06-01

492

Hereditary Multiple Exostoses with Pseudoaneurysm  

SciTech Connect

A 16-year-old male patient with hereditary multiple exostoses (HME) was found to have a pseudoaneurysm of the left popliteal artery caused by osteochondroma in the lower femur. The diagnosis was confirmed by ultrasound, magnetic resonance imaging and magnetic resonance angiography without the need to perform an angiogram. The osteochondroma was excised and the popliteal artery was repaired with a saphenous graft. Vascular complications are extremely rare in HME, pseudoaneurysm being the most common and mostly located in the popliteal artery. This complication should be considered in young HME patients with a mass at the knee region. The radiological spectrum of investigations allows the diagnosis of this complication with proper and less invasive management procedures for the patient.

Al-Hadidy, Azmy M. [Jordan University Hospital, University of Jordan, Department of Diagnostic Radiology (Jordan)], E-mail: ahadidy@ju.edu.jo; Al-Smady, Moa'ath M. [Jordan University Hospital, University of Jordan, Department of Vascular Surgery (Jordan); Haroun, Azmi A. [Jordan University Hospital, University of Jordan, Department of Diagnostic Radiology (Jordan); Hamamy, Hanan A. [National Institute for Diabetes Endocrinology and Genetics (Jordan); Ghoul, Suha M. [Jordan University Hospital, University of Jordan, Department of Diagnostic Radiology (Jordan); Shennak, Akram O. [Jordan University Hospital, University of Jordan, Department of Orthopedic Surgery (Jordan)

2007-06-15

493

Multiple differential-aperture microscopy  

NASA Astrophysics Data System (ADS)

Differential-aperture X-ray microscopy (DAXM) is a powerful approach to 3D tomography with particular relevance to X-ray microdiffraction. With DAXM, scattering from submicron volumes can be resolved. However, the method is intrinsically a scanning technique where every resolved volume element (voxel) requires at least one area-detector readout. Previous applications of DAXM have used a single wire for knife-edge step profiling. Here, we demonstrate a way to accelerate DAXM measurements using multiple wires. A proof-of-principle experiment with a three-wire prototype showed that the speed of measurements can be tripled, but careful calibrations of wires will be required to maintain the spatial accuracy. In addition, related possibilities for accelerating measurements are briefly discussed.

Chung, J.-S.; Isa, S.; Greene, V.; Broadwater, O.; Liu, W.; Ice, G. E.

2007-11-01

494

Naming Game with Multiple Hearers  

NASA Astrophysics Data System (ADS)

A new model called Naming Game with Multiple Hearers (NGMH) is proposed in this paper. A naming game over a population of individuals aims to reach consensus on the name of an object through pair-wise local interactions among all the individuals. The proposed NGMH model describes the learning process of a new word, in a population with one speaker and multiple hearers, at each interaction towards convergence. The characteristics of NGMH are examined on three types of network topologies, namely ER random-graph network, WS small-world network, and BA scale-free network. Comparative analysis on the convergence time is performed, revealing that the topology with a larger average (node) degree can reach consensus faster than the others over the same population. It is found that, for a homogeneous network, the average degree is the limiting value of the number of hearers, which reduces the individual ability of learning new words, consequently decreasing the convergence time; for a scale-free network, this limiting value is the deviation of the average degree. It is also found that a network with a larger clustering coefficient takes longer time to converge; especially a small-word network with smallest rewiring possibility takes longest time to reach convergence. As more new nodes are being added to scale-free networks with different degree distributions, their convergence time appears to be robust against the network-size variation. Most new findings reported in this paper are different from that of the single-speaker/single-hearer naming games documented in the literature.

Li, Bing; Chen, Guanrong; Chow, Tommy W. S.

2013-05-01

495

Diagnostic and operative problems in multiple pheochromocytomas.  

PubMed

Two children, aged 14 yr, with multiple pheochromocytomas are presented. Both patients had a positive family history. In the preoperative aortographies the intra-adrenal pheochromocytomas of both patients were well visualized, but not the extra-adrenal tumors of the first case. Chlorpromazine as an adrenergic blocking agent was successfully used in the preoperative treatment. Postoperative catecholamine excretion in the first case was repeatedly slightly increased indicating residual pheochromocytoma. In addition to the bilateral adrenal pheochromocytomas, multiple islet cell adrenomas and cholecystolithiasis were revealed at the operation of the second case. After bilateral adrenalectomy and total pancreaticoduodenectomy, regular follow-up examinations were carried out for 28 months. Hyperparathyroidism and signs of possible medullary thryoid carcinoma were discovered. Thus the patient had an unique pattern of MEA syndrome. PMID:191586

Heikkinen, E S; Akerblom, H K

1977-04-01

496

Multiple genetic alterations in human carcinogenesis.  

PubMed Central

Cancer development in man appeared to be a multistage process as suggested by epidemiological studies on commonly occurring gastric, colon, and breast cancers and also on human retrovirus-related leukemia, and by the finding by physicians and surgeons of precancerous lesions for many types of neoplasias. In the last 10 years it has become evident that human cancers have multiple genetic alterations caused by point mutations, recombinations, amplifications, and/or deletions. The genes affected include both oncogenes and tumor-suppressor genes and genes that accelerate cell proliferation and metastasis. Cancers with more malignant properties and poorer prognosis are generally associated with larger numbers of genetic alterations. These multiple genetic alterations are considered to be a direct reflection of the multiple steps involved in carcinogenesis. The multiple genetic alterations are caused by multiple environmental carcinogenic substances or factors, each of which usually exists only at minute concentrations and does not exert any major impact alone except under particular occupational, iatrogenic, and locally geographic conditions. The fact that carcinogenesis is a multistep process involving multiple genetic alterations clearly needs to be taken into consideration in assessing the risks of environmental carcinogenic substances or factors. The increasing incidence of multiple primary cancers is also most easily understood from the viewpoint of multiple steps in carcinogenesis. Possible multiple approaches to cancer prevention should therefore be considered in relation to multistep carcinogenesis and multiple carcinogenic factors.

Sugimura, T; Terada, M; Yokota, J; Hirohashi, S; Wakabayashi, K

1992-01-01

497

RecQ helicases: multiple structures for multiple functions?  

PubMed Central

Approximately 1% of the open reading frames in the human genome encode proteins that function as DNA or RNA helicases. These enzymes act in all aspects of nucleic acid metabolism where the complementary strands of DNA:DNA or DNA:RNA duplexes require to be transiently opened. However, they perform wider roles in nucleic acid metabolism due to their ability to couple the energy derived from hydrolysis of ATP to their unidirectional translocation along strands of DNA?RNA. In this way, helicases can displace proteins from DNA?RNA, drive the migration of DNA junctions (such as the Holliday junction recombination intermediate), or generate superhelical tension in nucleic acid duplexes. Here, we review a subgroup of DNA helicase enzymes, the RecQ family, that has attracted considerable interest in recent years due to their role not only in suppression of genome instability, but also in the avoidance of human disease. We focus particularly on the protein structural motifs and the multiple assembly states that characterize RecQ helicases and discuss novel biophysical techniques to study the different RecQ structures present in solution. We also speculate on the roles of the different domains and oligomeric forms in defining which DNA structures will represent substrates for RecQ helicase-mediated transactions.

Vindigni, Alessandro; Hickson, Ian D.

2009-01-01

498

Curriculum Materials and Misconceptions Concerning Multiplication and Division.  

ERIC Educational Resources Information Center

Explores the extent to which presentations about multiplication and division involving decimals within three series of mathematics textbooks for grades three through eight help students to counter common learner misconceptions about multiplication and division. Results indicate that theory on conceptual change with its concomitant research have…

Graeber, Anna O.; Baker, Kay M.

1991-01-01