Science.gov

Sample records for multiple programs essential

  1. Multiple programs: essential to the scientific vitality of the DOE Defense Program Laboratories

    SciTech Connect

    Shoemaker, P; Barnes, P D; Cummings, J; Eagan, R; Edgeworth, J; Fortner, R; Green, G; Hazi, A; Katz, M; Poppe, C

    1997-01-01

    The future of the Department of Energy's Defense Program (DP) laboratories-Los Alamos, Livermore, and Sandia-has been extensively debated and examined over the past several years. To assist in this process, I have asked that a set of documents be prepared, which, when taken together, present a comprehensive picture of the three laboratories. This document describes the multiprogram nature of the DP laboratories and the value of their involvement in non-DP work as it relates to the nuclear weapons program. The other two documents, Integration and Collaboration.. Solving Science and Technology Problems for the Nation (DOE/DP-96009797) and Roles and Responsibilities of the Department of Energy Nuclear Weapons Laboratories in the Stockpile Stewardship and Management Program (DOE/DP-97000280), describe respectively the integrated nature of the DP laboratories and the roles of the laboratories as they meet their individual and collective responsibilities of ensuring the safety and reliabilities of the U.S. nuclear weapons stockpile.

  2. Establishing Essential Competencies for Program Evaluators

    ERIC Educational Resources Information Center

    Stevahn, Laurie; King, Jean A.; Ghere, Gail; Minnema, Jane

    2005-01-01

    This article presents a comprehensive taxonomy of essential competencies for program evaluators. First, the authors provide a rationale for developing evaluator competencies, along with a brief history of the initial development and validation of the taxonomy of essential evaluator competencies in King, Stevahn, Ghere, and Minnema (2001). Second,…

  3. Essential Criteria for Teacher Preparation Programs.

    ERIC Educational Resources Information Center

    National Student Education Association, Washington, DC.

    The Student National Education Association (Student NEA) has developed criteria for teacher preparation programs which it feels reinforce current standards, emphasize particular elements within the standards, or generate goals that require the attention or consideration of conditions viewed to be essential to students but not present in all…

  4. Addendum: Parker Charter Essential School's Wellness Program

    ERIC Educational Resources Information Center

    Horace, 2008

    2008-01-01

    Wellness is an integrated curriculum combining aspects of traditional health classes with physical education, games, fitness skills and other mind-body connection skills. The goals of Parker Charter Essential School's Wellness program developed by members of the Parker community are: (1) to develop and nurture resilience; (2) to foster and promote…

  5. Essential program components for perinatal home care.

    PubMed

    Goodwin, L

    1994-10-01

    Home care will continue to be a rapidly expanding area of health care. This growth will be evident in the perinatal nursing specialty. There are multiple models for delivery of perinatal home services. In each case, consideration needs to be given to licensing and other standards; to operational areas such as staffing, supplies, equipment, and reimbursement; and to quality issues, such as staff development, internal and external customer service, and a continuous quality improvement program. Successful marketing of the services requires recognition that the product is nursing care. PMID:7836991

  6. THE ESSENTIAL SUPPORTIVE FUNCTIONS IN THE COLLEGE INSTRUCTIONAL PROGRAM.

    ERIC Educational Resources Information Center

    RAINES, MAX S.

    VISITS TO 70 JUNIOR COLLEGES RESULTED IN THE COMPILATION OF A LIST OF 21 FUNCTIONS WHICH ARE ESSENTIAL IN A BASIC STUDENT PERSONNEL PROGRAM FOR ANY JUNIOR COLLEGE, REGARDLESS OF ITS TYPE, SIZE, LOCATION, OR STAGE OF DEVELOPMENT. THESE FUNCTIONS MAY BE GROUPED INTO SEVEN MAJOR CATEGORIES--(1) ORIENTATION, INCLUDING PRECOLLEGE INFORMATION, CAREER…

  7. Developing Essential Understanding of Multiplication and Division for Teaching Mathematics in Grades 3-5

    ERIC Educational Resources Information Center

    Otto, Albert; Caldwell, Janet; Hancock, Sarah Wallus; Zbiek, Rose Mary

    2011-01-01

    This book identifies and examines two big ideas and related essential understandings for teaching multiplication and division in grades 3-5. Big Idea 1 captures the notion that multiplication is usefully defined as a scalar operation. Problem situations modeled by multiplication have an element that represents the scalar and an element that…

  8. Multiple polymersomes for programmed release of multiple components.

    PubMed

    Kim, Shin-Hyun; Shum, Ho Cheung; Kim, Jin Woong; Cho, Jun-Cheol; Weitz, David A

    2011-09-28

    Long-term storage and controlled release of multiple components while avoiding cross-contamination have potentially important applications for pharmaceuticals and cosmetics. Polymersomes are very promising delivery vehicles but cannot be used to encapsulate multiple independent components and release them in a controlled manner. Here, we report a microfluidic approach to produce multiple polymersomes, or polymersomes-in-polymersome by design, enabling encapsulation and programmed release of multiple components. Monodisperse polymersomes are prepared from templates of double-emulsion drops, which in turn are injected as the innermost phase to form the second level of double-emulsion drops, producing double polymersomes. Using the same strategy, higher-order polymersomes are also prepared. In addition, incorporation of hydrophobic homopolymer into the different bilayers of the multiple polymersomes enables controlled and sequential dissociation of the different bilayer membranes in a programmed fashion. The high encapsulation efficiency of this microfluidic approach, as well as its programmability and the biocompatibility of the materials used to form the polymersomes, will provide new opportunities for practical delivery systems of multiple components. PMID:21838246

  9. Successful healthcare programs and projects: organization portfolio management essentials.

    PubMed

    Pickens, Scott; Solak, Jamie

    2005-01-01

    Many healthcare organization projects take more time and resources than planned and fail to deliver desired business outcomes. Healthcare IT is a major component of many projects and often undeservedly receives the blame for failure. Poor results are often not a result of faulty healthcare IT or poor project management or poor project execution alone. Many projects fail because of poor portfolio management--poor planning and management of the portfolio of initiatives designed to meet an organization's strategic goals. Because resources are limited, portfolio management enables organizations to more strategically allocate and manage their resources so care delivery, service delivery, and initiatives that advance organizations toward their strategic goals, including healthcare IT initiatives, can be accomplished at the levels of quality and service desired by an organization. Proper portfolio management is the essential foundation for program and project success and supports overall organization success. Without portfolio management, even programs and projects that execute flawlessly may not meet desired objectives. This article discusses the essential requirements for porfolio management. These include opportunity identification, return on investment (ROI) forecast, project prioritization, capacity planning (inclusive of human, financial, capital, and facilities resources), work scheduling, program and project management and execution, and project performance and value assessment. Portfolio management is essential to successful healthcare project execution. Theories are drawn from the Organizational Project Management Maturity Model (OPM3) work of the Project Management Institute and other leading strategy, planning, and organization change management research institutes. PMID:15682672

  10. Understanding science teacher enhancement programs: Essential components and a model

    NASA Astrophysics Data System (ADS)

    Spiegel, Samuel Albert

    Researchers and practioners alike recognize that "the national goal that every child in the United States has access to high-quality school education in science and mathematics cannot be realized without the availability of effective professional development of teachers" (Hewson, 1997, p. 16). Further, there is a plethora of reports calling for the improvement of professional development efforts (Guskey & Huberman, 1995; Kyle, 1995; Loucks-Horsley, Hewson, Love, & Stiles, 1997). In this study I analyze a successful 3-year teacher enhancement program, one form of professional development, to: (1) identify essential components of an effective teacher enhancement program; and (2) create a model to identify and articulate the critical issues in designing, implementing, and evaluating teacher enhancement programs. Five primary sources of information were converted into data: (1) exit questionnaires, (2) exit surveys, (3) exit interview transcripts, (4) focus group transcripts, and (5) other artifacts. Additionally, a focus group was used to conduct member checks. Data were analyzed in an iterative process which led to the development of the list of essential components. The Components are categorized by three organizers: Structure (e.g., science research experience, a mediator throughout the program), Context (e.g., intensity, collaboration), and Participant Interpretation (e.g., perceived to be "safe" to examine personal beliefs and practices, actively engaged). The model is based on: (1) a 4-year study of a successful teacher enhancement program; (2) an analysis of professional development efforts reported in the literature; and (3) reflective discussions with implementors, evaluators, and participants of professional development programs. The model consists of three perspectives, cognitive, symbolic interaction, and organizational, representing different viewpoints from which to consider issues relevant to the success of a teacher enhancement program. These

  11. Essential Elements of an Effective Prison Hospice Program.

    PubMed

    Cloyes, Kristin G; Rosenkranz, Susan J; Berry, Patricia H; Supiano, Katherine P; Routt, Meghan; Shannon-Dorcy, Kathleen; Llanque, Sarah M

    2016-05-01

    As the number of prison inmates facing end-stage chronic illness grows, more prisons across the U.S. must address the need for end-of-life care. Many will likely need to develop a plan with potentially limited resources and external support. This case study presents one long-running model of care, the Louisiana State Penitentiary Prison Hospice Program. Based on field observations and in-depth interviews with hospice staff, inmate volunteers and corrections officers, we identify five essential elements that have contributed to the long-term operation of this program: patient-centered care, an inmate volunteer model, safety and security, shared values, and teamwork. We describe key characteristics of each of these elements, discuss how they align with earlier recommendations and research, and show how their integration supports a sustained model of prison end-of-life care. PMID:25735806

  12. Essential Elements of an Effective and Sustainable Prison Hospice Program

    PubMed Central

    Cloyes, Kristin G.; Rosenkranz, Susan J.; Berry, Patricia H.; Supiano, Katherine P.; Routt, Meghan; Shannon-Dorcy, Kathleen; Llanque, Sarah M.

    2015-01-01

    As the number of prison inmates facing end-stage chronic illness grows, more prisons across the U.S. must address the need for end-of-life care. Many will likely need to develop a plan with potentially limited resources and external support. This case study presents one long-running model of care, the Louisiana State Penitentiary Prison Hospice Program. Based on field observations and in-depth interviews with hospice staff, inmate volunteers and corrections officers, we identify five essential elements that have contributed to the long-term operation of this program: patient-centered care, an inmate volunteer model, safety and security, shared values, and teamwork. We describe key characteristics of each of these elements, discuss how they align with earlier recommendations and research, and show how their integration supports a sustained model of prison end-of-life care. PMID:25735806

  13. Bit allocation for joint coding of multiple video programs

    NASA Astrophysics Data System (ADS)

    Wang, Limin; Vincent, Andre

    1997-01-01

    By dynamically distributing the channel capacity among video programs according to their respective scene complexities, joint coding has been a shown to be more efficient than independent coding for compression of multiple video programs. This paper examines the bit allocation issue for joint coding of multiple video programs and provides a bit allocation strategy that results in uniform picture quality among programs as will as within a program.

  14. Multiple multipole program computation of periodic structures

    NASA Astrophysics Data System (ADS)

    Hafner, Ch.

    1995-05-01

    The three-dimensional multiple multipole program (MMP) code based on the generalized multipole technique is outlined for readers who are not familiar with its concepts. This code was originally designed for computational electromagnetics. Rayleigh expansions and periodic boundary conditions are two new features that make MMP computations of arbitrary periodic structures efficient and that at the same time allow us to take advantage of the benefits of other MMP features, including surface impedance boundary conditions and a variety of available basis functions for modeling the electromagnetic field. The application of three-dimensional MMP to a simple grating of highly conducting wires with rectangular cross sections illustrates the high accuracy and the fast convergence of the method as well as the use of surface impedance boundary conditions. A more complicated biperiodic array of helical antennas demonstrates the application of thin-wire expansions in conjunction with regular MMP expansions. This model can be considered a simulation of a thin, anisotropic chiral slab with interesting characteristics.

  15. Essential factors for a healthy RN educational mobility program.

    PubMed

    Messmer, P R; Miller, E; Spruck, M

    1994-01-01

    There is little research concerning which factors registered nurse (RN) students perceive as constituting a healthy educational mobility program. Because of this, a study was undertaken to identify the factors that RN students perceive as contributing to a healthy educational mobility RN/BSN/MSN program. Findings indicated that the RN students value flexibility, ease in planning, and convenience of course offerings as most important to their program selection. Registered nurse students emphasized the critical factors of faculty sensitivity to students' diverse opinions, faculty respect for students, and faculty expertise as important. These findings highlight the importance of sensitizing faculty members and nurse administrators to the needs of RN students. PMID:7854637

  16. Essential components of a successful doctoral program in nanomedicine.

    PubMed

    van de Ven, Anne L; Shann, Mary H; Sridhar, Srinivas

    2015-01-01

    The Nanomedicine program at Northeastern University provides a unique interdisciplinary graduate education that combines experiential research, didactic learning, networking, and outreach. Students are taught how to apply nanoscience and nanotechnology to problems in medicine, translate basic research to the development of marketable products, negotiate ethical and social issues related to nanomedicine, and develop a strong sense of community involvement within a global perspective. Since 2006, the program has recruited 50 doctoral students from ten traditional science, technology, and engineering disciplines to participate in the 2-year specialization program. Each trainee received mentoring from two or more individuals, including faculty members outside the student's home department and faculty members at other academic institutions, and/or clinicians. Both students and faculty members reported a significant increase in interdisciplinary scholarly activities, including publications, presentations, and funded research proposals, as a direct result of the program. Nearly 90% of students graduating with a specialization in nanomedicine have continued on to careers in the health care sector. Currently, 43% of graduates are performing research or developing products that directly involve nanomedicine. This article identifies some key elements of the Nanomedicine program, describes how they were implemented, and reports on the metrics of success. PMID:25565801

  17. Essential components of a successful doctoral program in nanomedicine

    PubMed Central

    van de Ven, Anne L; Shann, Mary H; Sridhar, Srinivas

    2015-01-01

    The Nanomedicine program at Northeastern University provides a unique interdisciplinary graduate education that combines experiential research, didactic learning, networking, and outreach. Students are taught how to apply nanoscience and nanotechnology to problems in medicine, translate basic research to the development of marketable products, negotiate ethical and social issues related to nanomedicine, and develop a strong sense of community involvement within a global perspective. Since 2006, the program has recruited 50 doctoral students from ten traditional science, technology, and engineering disciplines to participate in the 2-year specialization program. Each trainee received mentoring from two or more individuals, including faculty members outside the student’s home department and faculty members at other academic institutions, and/or clinicians. Both students and faculty members reported a significant increase in interdisciplinary scholarly activities, including publications, presentations, and funded research proposals, as a direct result of the program. Nearly 90% of students graduating with a specialization in nanomedicine have continued on to careers in the health care sector. Currently, 43% of graduates are performing research or developing products that directly involve nanomedicine. This article identifies some key elements of the Nanomedicine program, describes how they were implemented, and reports on the metrics of success. PMID:25565801

  18. General Education or Occupational Programs: Essential, Desired, or Unnecessary.

    ERIC Educational Resources Information Center

    Baum, Harold J.

    After discussing the conclusions of a Congressional Budget Office study, which recommended that federal aid be redirected from colleges to secondary programs more directly related to job training, this paper examines the need to plan general and technical education within the framework of national productivity. The decreasing productivity rate of…

  19. Programming of Essential Hypertension: What Pediatric Cardiologists Need to Know.

    PubMed

    Morgado, Joana; Sanches, Bruno; Anjos, Rui; Coelho, Constança

    2015-10-01

    Hypertension is recognized as one of the major contributing factors to cardiovascular disease, but its etiology remains incompletely understood. Known genetic and environmental influences can only explain a small part of the variability in cardiovascular disease risk. The missing heritability is currently one of the most important challenges in blood pressure and hypertension genetics. Recently, some promising approaches have emerged that move beyond the DNA sequence and focus on identification of blood pressure genes regulated by epigenetic mechanisms such as DNA methylation, histone modification and microRNAs. This review summarizes information on gene-environmental interactions that lead toward the developmental programming of hypertension with specific reference to epigenetics and provides pediatricians and pediatric cardiologists with a more complete understanding of its pathogenesis. PMID:26015087

  20. Short-term outcomes of a program developed to inculcate research essentials in undergraduate medical students

    PubMed Central

    Devi, V; Ramnarayan, K; Abraham, RR; Pallath, V; Kamath, A; Kodidela, S

    2015-01-01

    Background: Participation in research during undergraduate studies may increase students’ interest in research and inculcate research essentials in them. Aims: The purpose of this study was to evaluate the effectiveness of the mentored student project (MSP) program. Settings and Design: In the MSP program, students in groups (n = 3 to 5) undertook a research project, wrote a scholarly report, and presented the work as a poster presentation with the help of a faculty mentor. To begin with, the logic model of the program was developed to identify short-term outcomes of the program on students, mentors, and the institution. A quasi-experimental design was used to measure the outcomes. Materials and Methods: A mixed method evaluation was done using a newly-developed questionnaire to assess the impact of the MSP on students’ attitude, a multiple-choice question (MCQs) test to find out the impact on students’ knowledge and grading of students’ project reports and posters along with a survey to check the impact on skills. Students’ satisfaction regarding the program and mentors’ perceptions were collected using questionnaires. Evidence for validity was collected for all the instruments used for the evaluation. Statistical Analysis: Non-parametric tests were used to analyze data. Based on the scores, project reports and posters were graded into A (>70% marks), B (60-69% marks), and C (<59% marks) categories. The number of MSPs that resulted in publications, conference presentation and departmental collaborations were taken as impact on the institution. Results: Students’ response rate was 91.5%. The students’ attitudes regarding research changed positively (P = 0.036) and score in the MCQ test improved (P < 0.001) after undertaking MSP. Majority of project reports and posters were of grade A category. The majority of the items related to skills gained and satisfaction had a median score of 4. The MSPs resulted in inter-departmental and inter

  1. Retinoblastoma Protein Plays Multiple Essential Roles in the Terminal Differentiation of Sertoli Cells

    PubMed Central

    Nalam, Roopa L.; Andreu-Vieyra, Claudia; Braun, Robert E.; Akiyama, Haruhiko; Matzuk, Martin M.

    2009-01-01

    Retinoblastoma protein (RB) plays crucial roles in cell cycle control and cellular differentiation. Specifically, RB impairs the G1 to S phase transition by acting as a repressor of the E2F family of transcriptional activators while also contributing towards terminal differentiation by modulating the activity of tissue-specific transcription factors. To examine the role of RB in Sertoli cells, the androgen-dependant somatic support cell of the testis, we created a Sertoli cell-specific conditional knockout of Rb. Initially, loss of RB has no gross effect on Sertoli cell function because the mice are fertile with normal testis weights at 6 wk of age. However, by 10–14 wk of age, mutant mice demonstrate severe Sertoli cell dysfunction and infertility. We show that mutant mature Sertoli cells continue cycling with defective regulation of multiple E2F1- and androgen-regulated genes and concurrent activation of apoptotic and p53-regulated genes. The most striking defects in mature Sertoli cell function are increased permeability of the blood-testis barrier, impaired tissue remodeling, and defective germ cell-Sertoli cell interactions. Our results demonstrate that RB is essential for proper terminal differentiation of Sertoli cells. PMID:19819985

  2. ac18 is not essential for the propagation of Autographa californica multiple nucleopolyhedrovirus

    SciTech Connect

    Wang Yanjie; Wu Wenbi; Li Zhaofei; Yuan Meijin; Feng Guozhong; Yu Qian; Yang Kai Pang Yi

    2007-10-10

    orf18 (ac18) of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is a highly conserved gene in lepidopteran nucleopolyhedroviruses, but its function remains unknown. In this study, an ac18 knockout AcMNPV bacmid was generated to determine the role of ac18 in baculovirus life cycle. After transfection of Sf-9 cells, the ac18-null mutant showed similar infection pattern to the parent virus and the ac18 repair virus with respect to the production of infectious budded virus, occlusion bodies, or the formation of nucleocapsids as visualized by electron microscopy. The deletion mutant did not reduce AcMNPV infectivity for Trichoplusia ni in LD{sub 50} bioassay; however, it did take 24 h longer for deleted mutant to kill T. ni larvae than wild-type virus in LT{sub 50} bioassay. Our results demonstrate that ac18 is not essential for viral propagation both in vitro and in vivo, but it may play a role in efficient virus infection in T. ni larvae.

  3. Formative Evaluation of the Adult Learning, Literacy and Essential Skills Program. Final Report

    ERIC Educational Resources Information Center

    Human Resources and Skills Development Canada, 2010

    2010-01-01

    This report presents the results of the formative evaluation of the Adult Learning, Literacy and Essential Skills Program (ALLESP). Data collection related to this evaluation took place between November 2008 and May 2009. The evaluation resulted in the following four recommendations: (1) It is recommended that Program objectives and activities…

  4. Parents' Perceptions of the Factors Essential for Integrated Physical Education Programs.

    ERIC Educational Resources Information Center

    Downing, John H.; Rebollo, Joanne

    1999-01-01

    A survey of 75 parents of elementary students with physical disabilities investigated their perspectives regarding the factors essential for placement into integrated physical-education programs. Results found they believed that class size, program support, physical and communicative skills, health status, and motivation were prerequisites of an…

  5. Essential Characteristics for a Professional Development Program for Promoting the Implementation of a Multidisciplinary Science Module

    ERIC Educational Resources Information Center

    Visser, Talitha C.; Coenders, Fer G. M.; Terlouw, Cees; Pieters, Jules M.

    2010-01-01

    Teachers involved in the implementation of a curriculum innovation can be prepared for this task through a professional development program. In this paper, we describe essential characteristics (identified empirically and theoretically) for such a professional development program that promotes the acquisition of competences by these teachers. The…

  6. An efficient method for generalized linear multiplicative programming problem with multiplicative constraints.

    PubMed

    Zhao, Yingfeng; Liu, Sanyang

    2016-01-01

    We present a practical branch and bound algorithm for globally solving generalized linear multiplicative programming problem with multiplicative constraints. To solve the problem, a relaxation programming problem which is equivalent to a linear programming is proposed by utilizing a new two-phase relaxation technique. In the algorithm, lower and upper bounds are simultaneously obtained by solving some linear relaxation programming problems. Global convergence has been proved and results of some sample examples and a small random experiment show that the proposed algorithm is feasible and efficient. PMID:27547676

  7. Essential Indicators Identifying Chronic Inorganic Mercury Intoxication: Pooled Analysis across Multiple Cross-Sectional Studies

    PubMed Central

    Doering, Stefan

    2016-01-01

    Background The continuous exposure to inorganic mercury vapour in artisanal small-scale gold mining (ASGM) areas leads to chronic health problems. It is therefore essential to have a quick, but reliable risk assessing tool to diagnose chronic inorganic mercury intoxication. This study re-evaluates the state-of-the-art toolkit to diagnose chronic inorganic mercury intoxication by analysing data from multiple pooled cross-sectional studies. The primary research question aims to reduce the currently used set of indicators without affecting essentially the capability to diagnose chronic inorganic mercury intoxication. In addition, a sensitivity analysis is performed on established biomonitoring exposure limits for mercury in blood, hair, urine and urine adjusted by creatinine, where the biomonitoring exposure limits are compared to thresholds most associated with chronic inorganic mercury intoxication in artisanal small-scale gold mining. Methods Health data from miners and community members in Indonesia, Tanzania and Zimbabwe were obtained as part of the Global Mercury Project and pooled into one dataset together with their biomarkers mercury in urine, blood and hair. The individual prognostic impact of the indicators on the diagnosis of mercury intoxication is quantified using logistic regression models. The selection is performed by a stepwise forward/backward selection. Different models are compared based on the Bayesian information criterion (BIC) and Cohen`s kappa is used to evaluate the level of agreement between the diagnosis of mercury intoxication based on the currently used set of indicators and the result based on our reduced set of indicators. The sensitivity analysis of biomarker exposure limits of mercury is based on a sequence of chi square tests. Results The variable selection in logistic regression reduced the number of medical indicators from thirteen to ten in addition to the biomarkers. The estimated level of agreement using ten of thirteen medical

  8. Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption.

    PubMed

    Xu, H; Snider, T N; Wimer, H F; Yamada, S S; Yang, T; Holmbeck, K; Foster, B L

    2016-01-01

    Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a transmembrane zinc-endopeptidase that breaks down extracellular matrix components, including several collagens, during tissue development and physiological remodeling. MT1-MMP-deficient mice (MT1-MMP(-/-)) feature severe defects in connective tissues, such as impaired growth, osteopenia, fibrosis, and conspicuous loss of molar tooth eruption and root formation. In order to define the functions of MT1-MMP during root formation and tooth eruption, we analyzed the development of teeth and surrounding tissues in the absence of MT1-MMP. In situ hybridization showed that MT1-MMP was widely expressed in cells associated with teeth and surrounding connective tissues during development. Multiple defects in dentoalveolar tissues were associated with loss of MT1-MMP. Root formation was inhibited by defective structure and function of Hertwig's epithelial root sheath (HERS). However, no defect was found in creation of the eruption pathway, suggesting that tooth eruption was hampered by lack of alveolar bone modeling/remodeling coincident with reduced periodontal ligament (PDL) formation and integration with the alveolar bone. Additionally, we identified a significant defect in dentin formation and mineralization associated with the loss of MT1-MMP. To segregate these multiple defects and trace their cellular origin, conditional ablation of MT1-MMP was performed in epithelia and mesenchyme. Mice featuring selective loss of MT1-MMP activity in the epithelium were indistinguishable from wild type mice, and importantly, featured a normal HERS structure and molar eruption. In contrast, selective knock-out of MT1-MMP in Osterix-expressing mesenchymal cells, including osteoblasts and odontoblasts, recapitulated major defects from the global knock-out including altered HERS structure, short roots, defective dentin formation and mineralization, and reduced alveolar bone formation, although molars were able to erupt. These data

  9. Program Aids Specification Of Multiple-Block Grids

    NASA Technical Reports Server (NTRS)

    Sorenson, R. L.; Mccann, K. M.

    1993-01-01

    3DPREP computer program aids specification of multiple-block computational grids. Highly interactive graphical preprocessing program designed for use on powerful graphical scientific computer workstation. Divided into three main parts, each corresponding to principal graphical-and-alphanumerical display. Relieves user of some burden of collecting and formatting many data needed to specify blocks and grids, and prepares input data for NASA's 3DGRAPE grid-generating computer program.

  10. Developing an "essential functions" rubric: purposes and applications for speech-language-hearing academic programs.

    PubMed

    Horner, Jennifer; Schwarz, Ilsa; Jackson, Roberta; Johnstone, Patti; Mulligan, Moira; Roberts, Kathleen; Sohlberg, McKay Moore

    2009-01-01

    This article describes the purpose and application of an essential functions rubric for prospective and current students engaged in the study of communication sciences and disorders. Adopted in 2007 by the Council on Academic Programs in Communication Sciences and Disorders (CAPCSD), the essential functions rubric identifies core skills and attributes in five areas: communication, motor, intellectual-cognitive, sensory/observational, and behavioral/social. CAPCSD does not intend the rubric to be prescriptive but rather expects that it will be adapted to reflect the unique mission or circumstances of each academic program. The value of an essential functions rubric for academic programs is the opportunity it provides to educate students about the roles and responsibilities of the disciplines. A rubric also allows academic programs an objective basis for counseling students about professional expectations. Importantly, an essential functions rubric gives both students and programs opportunities to determine what, if any, accommodations might be employed to allow students who are otherwise qualified to help them succeed both academically and clinically. PMID:20011824

  11. ModMAP (Modular Multiple Alternatives Program). Program Description 1973-1974.

    ERIC Educational Resources Information Center

    Bridgeport Univ., CT. Coll. of Education.

    The Modular Multiple Alternatives Program (ModMaP), being developed at the University of Bridgeport, is the first competency-based, individualized graduate program in teacher education in the state of Connecticut. The program focuses on elementary teacher training and includes both master's and six-year level options. The program provides the…

  12. Essential Components of Educational Programming for Students with Behaviour Disabilities. Standards for Special Education

    ERIC Educational Resources Information Center

    Online Submission, 2006

    2006-01-01

    The purpose of this publication is to identify the essential components of appropriate programming mandated by Alberta Education for students with special education needs, to provide examples of effective practices, to establish a common understanding of the terminology associated with this specialized field, and to clarify the meaning of…

  13. Identification of Essential Food Skills for Skill-Based Healthful Eating Programs in Secondary Schools

    ERIC Educational Resources Information Center

    Fordyce-Voorham, Sandra

    2011-01-01

    Objective: To identify the food skills deemed essential to include in skill-based healthful eating programs in secondary schools. Methods: Fifty-one food experts including home economics educators, chefs, nutritionists and dietitians, community educators, homemakers, and young people were recruited by invitation, mail, and advertising. Data were…

  14. Essential Communication and Documentation Skills. Module: Introduction and Orientation to the Program.

    ERIC Educational Resources Information Center

    Medina, Muriel; And Others

    This module is the first of 10 in the Essential Communication and Documentation Skills curriculum. It establishes the program objectives and sets the tone for the full week of training. The curriculum is designed to improve the competence of New York State Division for Youth direct care staff in the workplace areas of observation, reading,…

  15. 78 FR 6275 - Medicaid, Children's Health Insurance Programs, and Exchanges: Essential Health Benefits in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... 457 Office of the Secretary 45 CFR Part 155 RIN 0938-AR04 Medicaid, Children's Health Insurance... Federal Register entitled ``Medicaid, Children's Health Insurance Programs, and Exchanges: Essential.... SUPPLEMENTARY INFORMATION: I. Background In FR Doc. 2013-00659 of January 22, 2013 (78 FR 4594), there was...

  16. Autographa californica multiple nucleopolyhedrovirus PK-1 is essential for nucleocapsid assembly

    SciTech Connect

    Liang, Changyong; Li, Min; Dai, Xuejuan; Zhao, Shuling; Hou, Yanling; Zhang, Yongli; Lan, Dandan; Wang, Yun; Chen, Xinwen

    2013-09-01

    PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase and its function is unclear. Our results showed that a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect. qPCR analysis demonstrated that pk-1 deletion did not affect viral DNA replication. Analysis of the repaired recombinants with truncated pk-1 mutants demonstrated that the catalytic domain of protein kinases of PK-1 was essential to viral infectivity. Moreover, those PK-1 mutants that could rescue the infectious BV production defect exhibited kinase activity in vitro. Therefore, it is suggested that the kinase activity of PK-1 is essential in regulating viral propagation. Electron microscopy revealed that pk-1 deletion affected the formation of normal nucleocapsids. Masses of electron-lucent tubular structures were present in cell transfected with pk-1 knockout bacmid. Therefore, PK-1 appears to phosphorylate some viral or cellular proteins that are essential for DNA packaging to regulate nucleocapsid assembly. - Highlights: • A pk-1 knockout AcMNPV failed to produce infectious progeny. • The pk-1 deletion did not affect viral DNA replication. • The catalytic domain of protein kinases (PKc) of PK-1 was essential to viral infectivity. • The kinase activity of PK-1 is essential in regulating viral propagation. • PK-1 appears to phosphorylate some viral proteins that are essential for DNA packaging to regulate nucleocapsid assembly.

  17. Essential Characteristics for a Professional Development Program for Promoting the Implementation of a Multidisciplinary Science Module

    NASA Astrophysics Data System (ADS)

    Visser, Talitha C.; Coenders, Fer G. M.; Terlouw, Cees; Pieters, Jules M.

    2010-10-01

    Teachers involved in the implementation of a curriculum innovation can be prepared for this task through a professional development program. In this paper, we describe essential characteristics (identified empirically and theoretically) for such a professional development program that promotes the acquisition of competences by these teachers. The innovation deals with the introduction of modules from a new multidisciplinary subject, in which elements from physics, chemistry, biology, mathematics, and physical geography are integrated. A 3-step approach was used to identify the essential characteristics: (a) evidence from classroom practice, (b) characteristics of the new subject, and (c) theoretical and empirical evidence from curriculum implementation studies. Analysis of the data showed that 5 characteristics need particular attention in a professional development program.

  18. Student Selection for Selective Educational Programs Using Multiple Criteria.

    ERIC Educational Resources Information Center

    Jenkins, Jerry A.

    This paper shows that multiple sources of data reflecting educational progress may be used with relative ease to systematically, objectively, and accurately place students in selective educational programs, such as those funded under Chapter 1 of the Education Consolidation and Improvement Act, using readily available commercial microcomputer…

  19. Max-margin Multiple-Instance Learning via Semidefinite Programming

    NASA Astrophysics Data System (ADS)

    Guo, Yuhong

    In this paper, we present a novel semidefinite programming approach for multiple-instance learning. We first formulate the multiple-instance learning as a combinatorial maximum margin optimization problem with additional instance selection constraints within the framework of support vector machines. Although solving this primal problem requires non-convex programming, we nevertheless can then derive an equivalent dual formulation that can be relaxed into a novel convex semidefinite programming (SDP). The relaxed SDP has mathcal{O}(T) free parameters where T is the number of instances, and can be solved using a standard interior-point method. Empirical study shows promising performance of the proposed SDP in comparison with the support vector machine approaches with heuristic optimization procedures.

  20. Essential functions for ID proteins at multiple checkpoints in natural killer T cell development

    PubMed Central

    Verykokakis, Mihalis; Krishnamoorthy, Veena; Iavarone, Antonio; Lasorella, Anna; Sigvardsson, Mikael; Kee, Barbara L.

    2013-01-01

    Invariant natural killer T (iNKT) cells display characteristics of both adaptive and innate lymphoid cells (ILCs). Like other ILCs, iNKT cells constitutively express ID proteins, which antagonize the E protein transcription factors that are essential for adaptive lymphocyte development. However, unlike ILCs, ID2 is not essential for thymic iNKT cell development. Here we demonstrated that ID2 and ID3 redundantly promoted iNKT cell lineage specification involving the induction of the signature transcription factor PLZF and that ID3 was critical for development of TBET-dependent NKT1 cells. In contrast, both ID2 and ID3 limited iNKT cell numbers by enforcing the post-selection checkpoint in conventional thymocytes. Therefore, iNKT cells show both adaptive and innate-like requirements for ID proteins at distinct checkpoints during iNKT cell development. PMID:24244015

  1. Essential components of an infection prevention program for outpatient hemodialysis centers.

    PubMed

    Hess, Sally; Bren, Virginia

    2013-01-01

    Infections are a significant complication for dialysis patients. The CDC estimates that 37,000 central line-related bloodstream infections occurred in hemodialysis patients in 2008 and dialysis-associated outbreaks of hepatitis C continue to be reported. While established hospital-based infection prevention programs have existed since the 1970s, few dialysis facilities have an established in-center program, unless the dialysis facility is hospital-associated. This review focuses on essential core components required for an effective infection prevention program, extrapolating from acute-care programs and building on current dialysis guidelines and recommendations. An effective infection prevention program requires infrastructure, including leaders who place infection prevention as a top priority, active involvement from a multidisciplinary team, surveillance of outcomes and processes with feedback, staff and patient education, and consistent use of evidence-based practices. The program must be integrated into the existing Quality Assessment and Performance Improvement program. Best practice recommendations for the prevention of infection, specific to dialysis, continue to evolve as the epidemiology of dialysis-associated infections is further researched and new evidence is gathered. A review of case studies illustrates that with an effective program in place, infection prevention becomes part of the culture, reduces infection risk, and improves patient safety. PMID:23808676

  2. Creating Synergy: Essential Components of a Successful R25E Cancer Education Program

    PubMed Central

    Gronemeyer, Suzanne A.

    2011-01-01

    For an R25E cancer research program to be a resounding success for both participating students and faculty, and to maintain federal funding, many synergistic elements are necessary. Essential components of the R25E Pediatric Oncology Education (POE) Program at St. Jude Children’s Research Hospital include 1) a unique focus, 2) a program director who is passionate about the program and who is enthusiastically supported by the institution, 3) committed and involved faculty mentors, 4) a current and complete program website with an online application process, 5) a large external network referring top students to the program, 6) an extensive, diverse, and highly qualified applicant pool with rigorous application requirements, 7) meticulous matching of faculty mentors with mentees, 8) adequate financial support for participants (stipend and housing), 9) an outstanding basic science and clinical research infrastructure, 10) Training in the protection of human subjects, the responsible conduct of research, and research with vertebrate animals, 11) a comprehensive lunch & learn seminar series, 12) oral and written participant presentations of their research results, 13) ongoing internal and external program evaluation, 14) long-term tracking of participants, and 15) continuing program innovation. PMID:21350929

  3. Developing a Wellness Program for People with Multiple Sclerosis

    PubMed Central

    Memoli, Ruth I.; Mason, Brian; Werneke, Mark W.

    2011-01-01

    Because multiple sclerosis (MS) is a multidimensional chronic disease, effective management of the illness requires a multidimensional approach. We describe a wellness program that was designed to facilitate positive health choices throughout the course of MS and present initial data analyses. We hypothesized that over the course of the program, participants would demonstrate improvement in the domains assessed. The wellness program included educational sessions in physical, mental, social, intellectual, and spiritual domains specifically targeting improved self-efficacy, physical functioning, coping skills, symptom management, and nutrition. An outcomes data collection software program was adapted to facilitate real-time patient self-report and clinician entry data collection for many domains throughout the wellness program. Initial assessment of serial measures (intake to discharge) from 65 people with MS showed improvement in several domains, including functional status (P < .05), fatigue (P < .05), fear-avoidance beliefs regarding physical activities (P < .05), depression (P < .05), somatization (P < .05), and pain (P < .05). In addition, using a model of risk for interpersonal distress, patients whose risk of elevated depression and anxiety decreased over the course of the program reported greater gains in functional status (P < .05). The results suggest possible future treatment strategies and indicate strengths and weaknesses of the wellness program, which are being used to improve the program. PMID:24453720

  4. Multiple program participation and exits from food stamps among elders.

    PubMed

    Issar, Sukriti

    2010-01-01

    This article uses population-level administrative data from Rhode Island's Food Stamp Program to examine exits from the Food Stamp Program by elders. Multivariate event history models estimate the relations of multiple program participation and the timing of eligibility reviews to the probability of exiting food stamps. Results suggest that elders who are age 65 or older and who receive both Supplemental Security Income and food stamps have a higher probability of exiting the Food Stamp Program than do elders who receive only food stamps. The timing of eligibility reviews is also found to be positively associated with the probability of exit from food stamps. This article is argued to extend conceptual models of the determinants of food stamp exits. PMID:20873021

  5. Development and organization of a multiple organ transplantation program.

    PubMed Central

    Bahnson, H T; Starzl, T E; Hakala, T R; Hardesty, R L; Griffith, B P; Iwatsuki, S

    1986-01-01

    Multiple organ transplantation has come of age. Indications are that it will continue to grow, if not flourish. The complexity of modern surgical care, its multiperson dependency, and the need for the surgeon to retain knowledge and involvement with his patient's care and problems are nowhere more evident than in multiple organ transplantation. Each organ presents its own associated challenges, the prime solution of which lies with a skillful and dedicated surgeon; but with all organs there are challenges of expectantly waiting patients, housing during the wait and for postoperative observation, procurement, erratic scheduling of the operating room, nursing, social service, immunosuppression, immunopathology, interest of hospital public relations and of the news media, and perennial care. This report concerns the growth and development of the multiple organ transplant program at the University Health Center of Pittsburgh and describes some answers to the challenges presented. PMID:3521507

  6. Drosophila SNAP-29 is an essential SNARE that binds multiple proteins involved in membrane traffic.

    PubMed

    Xu, Hao; Mohtashami, Mahmood; Stewart, Bryan; Boulianne, Gabrielle; Trimble, William S

    2014-01-01

    Each membrane fusion event along the secretory and endocytic pathways requires a specific set of SNAREs to assemble into a 4-helical coiled-coil, the so-called trans-SNARE complex. Although most SNAREs contribute one helix to the trans-SNARE complex, members of the SNAP-25 family contribute two helixes. We report the characterization of the Drosophila homologue of SNAP-29 (dSNAP-29), which is expressed throughout development. Unlike the other SNAP-25 like proteins in fruit fly (i.e., dSNAP-25 and dSNAP-24), which form SDS-resistant SNARE complexes with their cognate SNAREs, dSNAP-29 does not participate in any SDS-resistant complexes, despite its interaction with dsyntaxin1 and dsyntaxin16 in vitro. Immunofluorescence studies indicated that dSNAP-29 is distributed in various tissues, locating in small intracellular puncta and on the plasma membrane, where it associates with EH domain-containing proteins implicated in the endocytic pathway. Overexpression and RNAi studies suggested that dSNAP-29 mediates an essential process in Drosophila development. PMID:24626111

  7. Drosophila SNAP-29 Is an Essential SNARE That Binds Multiple Proteins Involved in Membrane Traffic

    PubMed Central

    Xu, Hao; Mohtashami, Mahmood; Stewart, Bryan; Boulianne, Gabrielle; Trimble, William S.

    2014-01-01

    Each membrane fusion event along the secretory and endocytic pathways requires a specific set of SNAREs to assemble into a 4-helical coiled-coil, the so-called trans-SNARE complex. Although most SNAREs contribute one helix to the trans-SNARE complex, members of the SNAP-25 family contribute two helixes. We report the characterization of the Drosophila homologue of SNAP-29 (dSNAP-29), which is expressed throughout development. Unlike the other SNAP-25 like proteins in fruit fly (i.e., dSNAP-25 and dSNAP-24), which form SDS-resistant SNARE complexes with their cognate SNAREs, dSNAP-29 does not participate in any SDS-resistant complexes, despite its interaction with dsyntaxin1 and dsyntaxin16 in vitro. Immunofluorescence studies indicated that dSNAP-29 is distributed in various tissues, locating in small intracellular puncta and on the plasma membrane, where it associates with EH domain-containing proteins implicated in the endocytic pathway. Overexpression and RNAi studies suggested that dSNAP-29 mediates an essential process in Drosophila development. PMID:24626111

  8. Influence of essential trace minerals and micronutrient insufficiencies on harmful metal overload in a Mongolian patient with multiple sclerosis.

    PubMed

    Komatsu, Fumio; Kagawa, Yasuo; Kawabata, Terue; Kaneko, Yoshinori; Kudoh, Hideki; Purvee, Baatar; Otgon, Jugder; Chimedregzen, Ulziiburen

    2012-07-01

    Parkinson's disease and other neurological disorders are prevalent in Mongolia. Our previous studies revealed a significant correlation of these diseases with high oxidative stress due to a high body burden of harmful metals, such as manganese, iron, lead, cadmium, and aluminum. This report describes a 37-year-old male Mongolian patient with multiple sclerosis and essential micronutrient deficiency. This patient demonstrated high oxidative stress, as shown by high urinary 8-hydroxy-2'-deoxyguanosine levels of 14.7 and 14.3 ng/mg creatinine (crea), although his hair levels of these toxic metals were markedly lower than other Mongolians. In addition, this patient was deficient not only in various essential minerals, including selenium, magnesium, copper, cobalt, vanadium, and nickel, but also in micronutrients such as vitamin B6, C, E, folic acid, niacin, and β-carotene. Furthermore, after taking 2,3-dimercaptosuccinic acid, a chelating agent, urinary excretion of lead, cadmium, manganese, aluminum, iron, copper, and lithium were increased 156-, 8.4-, 7.6-, 4.3-, 3.3-, 2.1-, and 2.1-fold, respectively. These results suggest that this patient suffered from a deficiency in micronutrients such as essential minerals and vitamins, which resulted in a disturbance in the ability to excrete harmful metals into the urine and hair. It is possible that a deficiency of micronutrients and a high burden of heavy metals play a role in the pathogenesis of multiple sclerosis. Nutritional treatment may be an effective approach to this disease. PMID:21834785

  9. Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.

    PubMed

    Suzuki, Shota; Kato, Hiroaki; Suzuki, Yutaka; Chikashige, Yuji; Hiraoka, Yasushi; Kimura, Hiroshi; Nagao, Koji; Obuse, Chikashi; Takahata, Shinya; Murakami, Yota

    2016-05-19

    In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its Set2-Rpb1 interaction (SRI) domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 is sufficient for recruitment of the Rpd3S histone deacetylase complex to repress cryptic transcription from transcribed regions. In fission yeast, Set2 is also responsible for H3K36 methylation, which represses a subset of RNAs including heterochromatic and subtelomeric RNAs, at least in part via recruitment of Clr6 complex II, a homolog of Rpd3S. Here, we show that CTD-S2P-dependent interaction of fission yeast Set2 with Pol2 via the SRI domain is required for formation of H3K36me3, but not H3K36me2. H3K36me3 silenced heterochromatic and subtelomeric transcripts mainly through post-transcriptional and transcriptional mechanisms, respectively, whereas H3K36me2 was not enough for silencing. Clr6 complex II appeared not to be responsible for heterochromatic silencing by H3K36me3. Our results demonstrate that H3K36 methylation has multiple outputs in fission yeast; these findings provide insights into the distinct roles of H3K36 methylation in metazoans, which have different enzymes for synthesis of H3K36me1/2 and H3K36me3. PMID:26792892

  10. A scalable parallel algorithm for multiple objective linear programs

    NASA Technical Reports Server (NTRS)

    Wiecek, Malgorzata M.; Zhang, Hong

    1994-01-01

    This paper presents an ADBASE-based parallel algorithm for solving multiple objective linear programs (MOLP's). Job balance, speedup and scalability are of primary interest in evaluating efficiency of the new algorithm. Implementation results on Intel iPSC/2 and Paragon multiprocessors show that the algorithm significantly speeds up the process of solving MOLP's, which is understood as generating all or some efficient extreme points and unbounded efficient edges. The algorithm gives specially good results for large and very large problems. Motivation and justification for solving such large MOLP's are also included.

  11. Feature extraction from multiple data sources using genetic programming.

    SciTech Connect

    Szymanski, J. J.; Brumby, Steven P.; Pope, P. A.; Eads, D. R.; Galassi, M. C.; Harvey, N. R.; Perkins, S. J.; Porter, R. B.; Theiler, J. P.; Young, A. C.; Bloch, J. J.; David, N. A.; Esch-Mosher, D. M.

    2002-01-01

    Feature extration from imagery is an important and long-standing problem in remote sensing. In this paper, we report on work using genetic programming to perform feature extraction simultaneously from multispectral and digital elevation model (DEM) data. The tool used is the GENetic Imagery Exploitation (GENIE) software, which produces image-processing software that inherently combines spatial and spectral processing. GENIE is particularly useful in exploratory studies of imagery, such as one often does in combining data from multiple sources. The user trains the software by painting the feature of interest with a simple graphical user interface. GENIE then uses genetic programming techniques to produce an image-processing pipeline. Here, we demonstrate evolution of image processing algorithms that extract a range of land-cover features including towns, grasslands, wild fire burn scars, and several types of forest. We use imagery from the DOE/NNSA Multispectral Thermal Imager (MTI) spacecraft, fused with USGS 1:24000 scale DEM data.

  12. Feature extraction from multiple data sources using genetic programming

    NASA Astrophysics Data System (ADS)

    Szymanski, John J.; Brumby, Steven P.; Pope, Paul A.; Eads, Damian R.; Esch-Mosher, Diana M.; Galassi, Mark C.; Harvey, Neal R.; McCulloch, Hersey D.; Perkins, Simon J.; Porter, Reid B.; Theiler, James P.; Young, Aaron C.; Bloch, Jeffrey J.; David, Nancy A.

    2002-08-01

    Feature extraction from imagery is an important and long-standing problem in remote sensing. In this paper, we report on work using genetic programming to perform feature extraction simultaneously from multispectral and digital elevation model (DEM) data. We use the GENetic Imagery Exploitation (GENIE) software for this purpose, which produces image-processing software that inherently combines spatial and spectral processing. GENIE is particularly useful in exploratory studies of imagery, such as one often does in combining data from multiple sources. The user trains the software by painting the feature of interest with a simple graphical user interface. GENIE then uses genetic programming techniques to produce an image-processing pipeline. Here, we demonstrate evolution of image processing algorithms that extract a range of land cover features including towns, wildfire burnscars, and forest. We use imagery from the DOE/NNSA Multispectral Thermal Imager (MTI) spacecraft, fused with USGS 1:24000 scale DEM data.

  13. HDAC4 governs a transcriptional program essential for synaptic plasticity and memory.

    PubMed

    Sando, Richard; Gounko, Natalia; Pieraut, Simon; Liao, Lujian; Yates, John; Maximov, Anton

    2012-11-01

    Neuronal activity influences genes involved in circuit development and information processing. However, the molecular basis of this process remains poorly understood. We found that HDAC4, a histone deacetylase that shuttles between the nucleus and cytoplasm, controls a transcriptional program essential for synaptic plasticity and memory. The nuclear import of HDAC4 and its association with chromatin is negatively regulated by NMDA receptors. In the nucleus, HDAC4 represses genes encoding constituents of central synapses, thereby affecting synaptic architecture and strength. Furthermore, we show that a truncated form of HDAC4 encoded by an allele associated with mental retardation is a gain-of-function nuclear repressor that abolishes transcription and synaptic transmission despite the loss of the deacetylase domain. Accordingly, mice carrying a mutant that mimics this allele exhibit deficits in neurotransmission, spatial learning, and memory. These studies elucidate a mechanism of experience-dependent plasticity and define the biological role of HDAC4 in the brain. PMID:23141539

  14. At-Risk Programs for Middle School and High School: Essential Components and Recommendations for Administrators and Teachers.

    ERIC Educational Resources Information Center

    Bateman, Susan; Karr-Kidwell, PJ

    This paper provides an extensive literature review concerning at-risk students and their needs, identifies the essential components necessary for effective at-risk programming, and describes successful at-risk programs and recommendations for administrators and teachers at the middle- and high-school levels. The literature review presents research…

  15. Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness.

    PubMed

    Perry, Marie-Claude; Dufour, Catherine R; Tam, Ingrid S; B'chir, Wafa; Giguère, Vincent

    2014-12-01

    Muscle fitness is an important determinant of health and disease. However, the molecular mechanisms involved in the coordinate regulation of the metabolic and structural determinants of muscle endurance are still poorly characterized. Herein, we demonstrate that estrogen-related receptor α (ERRα, NR3B1) is essential for skeletal muscle fitness. Notably, we show that ERRα-null animals are hypoactive and that genetic or therapeutic disruption of ERRα in mice results in reduced exercise tolerance. Mice lacking ERRα also exhibited lactatemia at exhaustion. Gene expression profiling demonstrates that ERRα plays a key role in various metabolic processes important for muscle function including energy substrate transport and use (Ldhd, Slc16a1, Hk2, and Glul), the tricarboxylic acid cycle (Cycs, and Idh3g), and oxidative metabolism (Pdha1, and Uqcrq). Metabolomics studies revealed impairment in replenishment of several amino acids (eg, glutamine) during recovery to exercise. Moreover, loss of ERRα was found to alter the expression of genes involved in oxidative stress response (Hmox1), maintenance of muscle fiber integrity (Trim63, and Hspa1b), and muscle plasticity and neovascularization (Vegfa). Taken together, our study shows that ERRα plays a key role in directing transcriptional programs required for optimal mitochondrial oxidative potential and muscle fitness, suggesting that modulation of ERRα activity could be used to manage metabolic myopathies and/or promote the adaptive response to physical exercise. PMID:25361393

  16. A comprehensive school-based/linked dental program: an essential piece of the California access to care puzzle.

    PubMed

    Fine, Jared I; Isman, Robert E; Grant, Catherine B

    2012-03-01

    California children suffer more from dental disease than any other chronic childhood disease. Disparities in access and oral health are disproportionately represented among children from minority and low-income families. A comprehensive school-based/linked dental program is one essential ingredient in addressing these problems. Described here are the goals, program elements, and challenges of building a seamless dental services system that could reduce barriers care, maximize resources, and employ best practices to improve oral health. PMID:22655421

  17. Learning to Question: The Roles of Multiple Hypotheses, Successive Approximations, Balloons and Toilet Paper in University Science Programs of Southwestern Amazonia

    ERIC Educational Resources Information Center

    Brown, I. Foster

    2008-01-01

    Learning to question is essential for determining pathways of conservation and development in southwestern Amazonia during a time of rapid global environmental change. Teaching such an approach in graduate science programs in regional universities can be done using play-acting and simulation exercises. Multiple working hypotheses help students…

  18. Programmed cell death (PCD): an essential process of cereal seed development and germination.

    PubMed

    Domínguez, Fernando; Cejudo, Francisco J

    2014-01-01

    The life cycle of cereal seeds can be divided into two phases, development and germination, separated by a quiescent period. Seed development and germination require the growth and differentiation of new tissues, but also the ordered disappearance of cells, which takes place by a process of programmed cell death (PCD). For this reason, cereal seeds have become excellent model systems for the study of developmental PCD in plants. At early stages of seed development, maternal tissues such as the nucellus, the pericarp, and the nucellar projections undergo a progressive degeneration by PCD, which allows the remobilization of their cellular contents for nourishing new filial tissues such as the embryo and the endosperm. At a later stage, during seed maturation, the endosperm undergoes PCD, but these cells remain intact in the mature grain and their contents will not be remobilized until germination. Thus, the only tissues that remain alive when seed development is completed are the embryo axis, the scutellum and the aleurone layer. In germinating seeds, both the scutellum and the aleurone layer play essential roles in producing the hydrolytic enzymes for the mobilization of the storage compounds of the starchy endosperm, which serve to support early seedling growth. Once this function is completed, scutellum and aleurone cells undergo PCD; their contents being used to support the growth of the germinated embryo. PCD occurs with tightly controlled spatial-temporal patterns allowing coordinated fluxes of nutrients between the different seed tissues. In this review, we will summarize the current knowledge of the tissues undergoing PCD in developing and germinating cereal seeds, focussing on the biochemical features of the process. The effect of hormones and redox regulation on PCD control will be discussed. PMID:25120551

  19. Programmed cell death (PCD): an essential process of cereal seed development and germination

    PubMed Central

    Domínguez, Fernando; Cejudo, Francisco J.

    2014-01-01

    The life cycle of cereal seeds can be divided into two phases, development and germination, separated by a quiescent period. Seed development and germination require the growth and differentiation of new tissues, but also the ordered disappearance of cells, which takes place by a process of programmed cell death (PCD). For this reason, cereal seeds have become excellent model systems for the study of developmental PCD in plants. At early stages of seed development, maternal tissues such as the nucellus, the pericarp, and the nucellar projections undergo a progressive degeneration by PCD, which allows the remobilization of their cellular contents for nourishing new filial tissues such as the embryo and the endosperm. At a later stage, during seed maturation, the endosperm undergoes PCD, but these cells remain intact in the mature grain and their contents will not be remobilized until germination. Thus, the only tissues that remain alive when seed development is completed are the embryo axis, the scutellum and the aleurone layer. In germinating seeds, both the scutellum and the aleurone layer play essential roles in producing the hydrolytic enzymes for the mobilization of the storage compounds of the starchy endosperm, which serve to support early seedling growth. Once this function is completed, scutellum and aleurone cells undergo PCD; their contents being used to support the growth of the germinated embryo. PCD occurs with tightly controlled spatial-temporal patterns allowing coordinated fluxes of nutrients between the different seed tissues. In this review, we will summarize the current knowledge of the tissues undergoing PCD in developing and germinating cereal seeds, focussing on the biochemical features of the process. The effect of hormones and redox regulation on PCD control will be discussed. PMID:25120551

  20. Multiple correlation computer program determines relationships between several independent and dependent variables

    NASA Technical Reports Server (NTRS)

    Kaspar, H.; Newsbaum, J. B.

    1967-01-01

    Relationships between independent and dependent variables are determined by multiple correlation computer program. This is applied to research and experimental design and development of complex hardware and components that require test programs.

  1. The Essential Theory of Literacy and Its Implications for Programming and Evaluation.

    ERIC Educational Resources Information Center

    Bhola, H. S.

    Anecdotal evidence from literacy educators sometimes suggests that many people can do well despite being illiterate; however, this perspective ignores the essential theory of literacy. This theory rests on the premise that the most essential difference between human beings and other creatures is the human ability to make "symbolic…

  2. It's as Easy as ABC: The Essential Elements of a Balanced Literacy Program. PreK-1.

    ERIC Educational Resources Information Center

    Jarboe, Tracy; Sadler, Stefani

    This book contains patterns and activities designed to supplement core literacy instruction, showing students how to work together within large- and small-group settings, independently in learning centers, or at home with their parents. Section 1, "Essential Elements and Skills of a Balanced Literacy Program," provides ideas on how to create a…

  3. Parents: An Essential Link to a Successful Reading Program (In the Classroom).

    ERIC Educational Resources Information Center

    Rucinski, Cindi A.; Kries, Carol

    1991-01-01

    Describes the "Magical PAIR" (Parents Actively Involved in Reading) program, initiated by a reading center for grades one through five, that is based on the premise that parents are a critical link to a successful reading program. (MG)

  4. Program Evaluation in Gifted Education. Essential Readings in Gifted Education Series

    ERIC Educational Resources Information Center

    Callahan, Carolyn M., Ed.; Reis, Sally M., Ed.

    2004-01-01

    The readings in this ready-reference report on specific program evaluations, offer critical guidance in the development and utilization of instruments for assessing gifted and talented programs, and are designed to stimulate the discussion of issues surrounding the evaluation of gifted programs. Key features include: (1) Carolyn M. Callahan's…

  5. Ed School Essentials: Evaluating the Fundamentals of Teacher Training Programs in Texas. Full Report

    ERIC Educational Resources Information Center

    Greenberg, Julie; Walsh, Kate

    2010-01-01

    In Texas, undergraduate teacher preparation programs graduate 9,300 new elementary, secondary and special education teachers, nearly half (43 percent) of the total number produced each year in the state. This report examines 67 of those programs on a range of standards. The standards bear directly on their programs' capacity to attract the most…

  6. Residency for Transition Into Practice: An Essential Requirement for New Graduates From Basic RN Programs.

    PubMed

    Goode, Colleen J; Reid Ponte, Patricia; Sullivan Havens, Donna

    2016-02-01

    Nurse residency programs have been developed with the goal of helping newly licensed nurses successfully transition to independent practice. The authors propose that all newly licensed nurses hired in acute care hospitals be required to complete an accredited residency program. An evidence table examines the state of the science related to transition-to-practice programs and provides the basis for recommendations. PMID:26771476

  7. MULTAN: a program to align multiple DNA sequences.

    PubMed Central

    Bains, W

    1986-01-01

    I describe a computer program which can align a large number of nucleic acid sequences with one another. The program uses an heuristic, iterative algorithm which has been tested extensively, and is found to produce useful alignments of a variety of sequence families. The algorithm is fast enough to be practical for the analysis of large number of sequences, and is implemented in a program which contains a variety of other functions to facilitate the analysis of the aligned result. PMID:3003672

  8. Small College Teacher Preparation Program Evaluations: A Multiple Case Study

    ERIC Educational Resources Information Center

    Saynes, Kathryn

    2013-01-01

    The methods of evaluating teacher preparation programs are becoming increasingly more reliant on student test data. These test data driven formats, however, are not appropriate for small colleges. Small colleges are currently left off the Tennessee Report Card on the Effectiveness of Teacher Training Programs because the colleges did not produce…

  9. Multiple Year Extension Program Outcomes & Impacts through Evaluation

    ERIC Educational Resources Information Center

    Hachfeld, Gary A.; Bau, David B.; Holcomb, C. Robert; Craig, J. William

    2013-01-01

    Dwindling public funding as well as greater competition for grant dollars create a challenge for Extension. For Extension to remain a financially viable organization, educators have to be able to produce substantive, measurable program outcomes and impacts. Evaluative data can inform program development and delivery, and helps administrators…

  10. Including Multiple Voices in Collaboratively Designing a Teacher Education Program

    ERIC Educational Resources Information Center

    Konecki, Loretta R.; Sturdivant, Robika L.; King, Caryn M.; Melin, Jacquelyn A.; Lancaster, Paula E.

    2012-01-01

    This narrative case study describes the collaborative processes employed by a midwestern university as it designed and implemented a clinically based, postbaccalaureate teacher preparation program for science, technology, engineering, and mathematics (STEM) graduates committed to teaching in high need secondary schools. The program development…

  11. 78 FR 42159 - Medicaid and Children's Health Insurance Programs: Essential Health Benefits in Alternative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... (FR Doc. 2012-6560) published on March 23, 2012, which were to become effective in January 1, 2014 are..., please refer to the Medicaid, CHIP, and Exchanges proposed rule (78 FR 4594). B. Essential Health... Plans; Exchange Standards for Employers'' (hereafter referred to as ``Exchange Final Rule'') (77...

  12. The Multiple Roles that Youth Development Program Leaders Adopt with Youth

    ERIC Educational Resources Information Center

    Walker, Kathrin C.

    2011-01-01

    The roles that program leaders establish in their relationships with youth structure how leaders are able to foster youth development. This article examines the complex roles program leaders create in youth programs and investigates how they balanced multiple roles to most effectively respond to the youth they serve. Analyses of qualitative data…

  13. Multiple-modality program for standoff detection of roadside hazards

    NASA Astrophysics Data System (ADS)

    Williams, Kathryn; Middleton, Seth; Close, Ryan; Luke, Robert H.; Suri, Rajiv

    2016-05-01

    The U.S. Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate (NVESD) is executing a program to assess the performance of a variety of sensor modalities for standoff detection of roadside explosive hazards. The program objective is to identify an optimal sensor or combination of fused sensors to incorporate with autonomous detection algorithms into a system of systems for use in future route clearance operations. This paper provides an overview of the program, including a description of the sensors under consideration, sensor test events, and ongoing data analysis.

  14. Costs of California Multiple Pathway Programs. Policy Report

    ERIC Educational Resources Information Center

    Parsi, Ace; Plank, David; Stern, David

    2010-01-01

    There is widespread agreement that many of California's high schools are doing a poor job of preparing their students for college and careers. The James Irvine Foundation is sponsoring a major initiative to develop "Multiple Pathways"--now called the Linked Learning approach--as a strategy for improving the performance of California high schools.…

  15. TESTER: A Computer Program to Produce Individualized Multiple Choice Tests.

    ERIC Educational Resources Information Center

    Hamer, Robert; Young, Forrest W.

    1978-01-01

    TESTER, a computer program which produces individualized objective tests from a pool of items, is described. Available in both PL/1 and FORTRAN, TESTER may be executed either interactively or in batch. (Author/JKS)

  16. Promoting Success for Dual Language Learners: The Essential Role of Early Childhood Education Programs

    ERIC Educational Resources Information Center

    Freedberg, Louis; Frey, Susan

    2016-01-01

    Early childhood education programs in California have a crucial role to play in preparing dual language learners to enter kindergarten with the skills they need to succeed in school and beyond. The reason is simple: there are more dual language learners under the age of 5 in early childhood education programs in California than anywhere else in…

  17. Mission Intentionality and Operational Integrity: The Essential Role of Faculty in Adult Degree Programs

    ERIC Educational Resources Information Center

    Blair, Anthony L.

    2012-01-01

    Eastern University has moved from a distributed model to a centralized model for administration of its adult degree programs. This move involved numerous factors and motivations but one central component in the ultimate success of that move was a significant change in the role of faculty assigned to the program. Once regarded as rather ancillary…

  18. Evaluation of the Person-Centered Care Essentials Program: Importance of Trainers in Achieving Targeted Outcomes

    ERIC Educational Resources Information Center

    King, Scott P.; O'Brien, Catherine J.; Edelman, Perry; Fazio, Sam

    2011-01-01

    A person-centered care (PCC) training program was developed and disseminated to 84 institutes for retired religious persons across the United States. The program was delivered via a train-the-trainer model wherein institute trainers attended a 2-day training conference, then taught the material to direct care workers (DCWs) at their respective…

  19. Labor Market Assessments: An Essential Data Element for Program Development and Evaluation.

    ERIC Educational Resources Information Center

    Friedel, Janice N.

    The Eastern Iowa Community College District (EICCD) has conducted labor market assessments in 17 occupations related to its programs. These assessments are an integral component of the EICCD program evaluation process. These assessments provide valuable information in the specific occupational areas regarding (1) characteristics of the local…

  20. Power Tools: 100+ Essential Forms and Presentations for Your School Library Information Program.

    ERIC Educational Resources Information Center

    Valenza, Joyce Kasman

    This package of materials presents ready-to-use forms that will help school library information specialists manage, promote, and assess their programs; increase the effectiveness of their program while reducing their workload; and help students develop information skills. The document consists of 117 reproducible loose-leaf forms, CD-ROM (for…

  1. The Key Essentials for Learning in the 21st Century: Programs and Practices

    ERIC Educational Resources Information Center

    Cho, Paulina

    2012-01-01

    The purpose of this case study was to generate new knowledge to learn about programs and practices that promote the acquisition of 21st century skills at a school. The study identified programs, pedagogical methods, and instructional practices of Charles Summon Elementary School that have contributed to the school's ability to prepare its…

  2. The Essential Role of Educator Development: 10 Years of the ACC Emerging Faculty Program.

    PubMed

    Auseon, Alex J; O'Gara, Patrick T; Klodas, Elizabeth; Holmes, David R; Jackson, Marcia J; Green, Joseph S; Konstam, Marvin A; Nishimura, Rick A

    2016-05-10

    The American College of Cardiology Emerging Faculty program was developed in 2005 to promote a systematic approach to "educate the educators" through training and mentorship. A primary focus of the program is the biennial Teaching Skills Workshop, which has had 130 participants since its inception and is focused on the concepts of effective adult learning, curriculum design, and optimization of presentation skills. A survey of participants (80 respondents of 130 total participants) found that the majority stated that participation in the program had a large impact on their ability to apply instructional design principles (49%) and present in face-to-face settings (47%), and it had a moderately large to large positive impact on their personal careers. Thus, the Emerging Faculty program combines several elements of the College's strategic plan in a single program that provides member value to early career professionals and sustained benefit for the cardiovascular community and patients. PMID:27151350

  3. The Development and Implementation of a Prenatal Education Program for Expectant Parents of Multiples

    PubMed Central

    Kuhnly, Joan Esper; Juliano, Marion; McLarney, Patricia Swider

    2015-01-01

    ABSTRACT Preparing expectant parents of multiples required a unique prenatal education program. A thorough explanation of the course layout, curriculum, and content the faculty developed for this unique 9-hour program is presented. The unique implications for parenting multiples was highlighted throughout the program, which included expectations for late pregnancy, preparation for labor and birth, assuring infant safety, learning how to provide infant care, identifying sources of support, breastfeeding information and support, potential for neonatal intensive care, postpartum depression, and providing a multiple parent’s personal perspective. All classes were interactive and used active learner-based teaching strategies. PMID:26957894

  4. Evaluation of large-scale combination HIV prevention programs: essential issues.

    PubMed

    Padian, Nancy S; McCoy, Sandra I; Manian, Shanthi; Wilson, David; Schwartländer, Bernhard; Bertozzi, Stefano M

    2011-10-01

    HIV prevention research has shifted to the evaluation of combination prevention programs whereby biomedical, behavioral, and structural interventions are implemented concurrently to maximize synergies among interventions. However, these kinds of combination prevention packages, particularly when implemented at scale, pose significant evaluation challenges, including how best to determine impact and how and whether to measure the effectiveness of component strategies. In addition, methodological challenges unique to HIV infection such as the absence of a reliable incidence assay, the lack of naive control groups, and no suitable surrogates further complicate rigorous evaluation. In this commentary, we discuss the key considerations for planning impact evaluations of combination HIV prevention programs in light of these challenges, including defining the evaluable package, determining which component programs require independent assessment of impact, choosing study designs with valid counterfactuals, selecting appropriate outcomes of interest, and the importance of mid-course program corrections. PMID:21694607

  5. Supporting Multiple Programs and Projects at NASA's Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Stewart, Camiren L.

    2014-01-01

    With the conclusion of the shuttle program in 2011, the National Aeronautics and Space Administration (NASA) had found itself at a crossroads for finding transportation of United States astronauts and experiments to space. The agency would eventually hand off the taxiing of American astronauts to the International Space Station (ISS) that orbits in Low Earth Orbit (LEO) about 210 miles above the earth under the requirements of the Commercial Crew Program (CCP). By privatizing the round trip journey from Earth to the ISS, the space agency has been given the additional time to focus funding and resources to projects that operate beyond LEO; however, adding even more stress to the agency, the premature cancellation of the program that would succeed the Shuttle Program - The Constellation Program (CxP) -it would inevitably delay the goal to travel beyond LEO for a number of years. Enter the Space Launch System (SLS) and the Orion Multipurpose Crew Vehicle (MPCV). Currently, the SLS is under development at NASA's Marshall Spaceflight Center in Huntsville, Alabama, while the Orion Capsule, built by government contractor Lockheed Martin Corporation, has been assembled and is currently under testing at the Kennedy Space Center (KSC) in Florida. In its current vision, SLS will take Orion and its crew to an asteroid that had been captured in an earlier mission in lunar orbit. Additionally, this vehicle and its configuration is NASA's transportation to Mars. Engineers at the Kennedy Space Center are currently working to test the ground systems that will facilitate the launch of Orion and the SLS within its Ground Services Development and Operations (GSDO) Program. Firing Room 1 in the Launch Control Center (LCC) has been refurbished and outfitted to support the SLS Program. In addition, the Spaceport Command and Control System (SCCS) is the underlying control system for monitoring and launching manned launch vehicles. As NASA finds itself at a junction, so does all of its

  6. Multiple Perspectives on the Quality of Programs for Young Children.

    ERIC Educational Resources Information Center

    Katz, Lilian G.

    This paper comments on issues of quality in early child care and education from an international perspective, asserting that questions about how to determine quality are as complex for early childhood programs as for all other professional services. The paper's introduction discusses the world wide trend of expansion in the amount of out-of-home…

  7. SuhB Is a Regulator of Multiple Virulence Genes and Essential for Pathogenesis of Pseudomonas aeruginosa

    PubMed Central

    Li, Kewei; Xu, Chang; Jin, Yongxin; Sun, Ziyu; Liu, Chang; Shi, Jing; Chen, Gukui; Chen, Ronghao; Jin, Shouguang; Wu, Weihui

    2013-01-01

    ABSTRACT During initial colonization and chronic infection, pathogenic bacteria encounter distinct host environments. Adjusting gene expression accordingly is essential for the pathogenesis. Pseudomonas aeruginosa has evolved complicated regulatory networks to regulate different sets of virulence factors to facilitate colonization and persistence. The type III secretion system (T3SS) and motility are associated with acute infections, while biofilm formation and the type VI secretion system (T6SS) are associated with chronic persistence. To identify novel regulatory genes required for pathogenesis, we screened a P. aeruginosa transposon (Tn) insertion library and found suhB to be an essential gene for the T3SS gene expression. The expression of suhB was upregulated in a mouse acute lung infection model, and loss of suhB resulted in avirulence. Suppression of T3SS gene expression in the suhB mutant is linked to a defective translation of the T3SS master regulator, ExsA. Further studies demonstrated that suhB mutation led to the upregulation of GacA and its downstream small RNAs, RsmY and RsmZ, triggering T6SS expression and biofilm formation while inhibiting the T3SS. Our results demonstrate that an in vivo-inducible gene, suhB, reciprocally regulates genes associated with acute and chronic infections and plays an essential role in the pathogenesis of P. aeruginosa. PMID:24169572

  8. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis

    PubMed Central

    Young, Samantha A. M.; Miyata, Haruhiko; Satouh, Yuhkoh; Kato, Hirotaka; Nozawa, Kaori; Isotani, Ayako; Aitken, R. John; Baker, Mark A.; Ikawa, Masahito

    2015-01-01

    Spermatozoa are flagellated cells whose role in fertilization is dependent on their ability to move towards an oocyte. The structure of the sperm flagella is highly conserved across species, and much of what is known about this structure is derived from studies utilizing animal models. One group of proteins essential for the movement of the flagella are the dyneins. Using the advanced technology of CRISPR/Cas9 we have targeted three dynein group members; Dnaic1, Wdr63 and Ccdc63 in mice. All three of these genes are expressed strongly in the testis. We generated mice with amino acid substitutions in Dnaic1 to analyze two specific phosphorylation events at S124 and S127, and generated simple knockouts of Wdr63 and Ccdc63. We found that the targeted phosphorylation sites in Dnaic1 were not essential for male fertility. Similarly, Wdr63 was not essential for male fertility; however, Ccdc63 removal resulted in sterile male mice due to shortened flagella. This study demonstrates the versatility of the CRISPR/Cas9 system to generate animal models of a highly complex system by introducing point mutations and simple knockouts in a fast and efficient manner. PMID:26501274

  9. 75 FR 54073 - Medicaid Program; Withdrawal of Determination of Average Manufacturer Price, Multiple Source Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... final rule, titled ``Medicaid Program; Prescription Drugs'' in the Federal Register (72 FR 39142...; Withdrawal of Determination of Average Manufacturer Price, Multiple Source Drug Definition, and Upper Limits... determination of average manufacturer price (AMP), and the Federal upper limits (FULs) for multiple source...

  10. Essential components of a tuberculosis prevention and control program. Recommendations of the Advisory Council for the Elimination of Tuberculosis.

    PubMed

    1995-09-01

    Tuberculosis (TB) rates declined steadily for decades in the United States, but several complex social and medical factors caused TB morbidity to increase 14% from 1985 through 1993. The recent increases in TB morbidity have placed additional demands on state and local TB control programs, which already had been substantially weakened by inadequate staffing and funding support. TB programs throughout the nation must be revitalized if they are to provide core TB control activities that enable effective responses to this public health challenge. This report describes a model for TB control programs and the essential components of a successful TB control program, including three priority strategies for TB prevention and control: a) identifying and treating persons who have active TB, b) finding and screening persons who have had contact with TB patients to determine whether they are infected with Mycobacterium tuberculosis or have active TB and providing appropriate treatment, and c) screening populations at high risk for TB infection and the development of TB disease to detect infected persons and providing therapy to prevent progression to active TB. State and local health departments have primary responsibility for preventing and controlling TB. To meet this challenge successfully, TB control programs should be able to administer activities that include the following core components: conducting overall planning and development of policy, identifying persons who have clinically active TB, managing persons who have or who are suspected of having disease, identifying and managing persons infected with M. tuberculosis, providing laboratory and diagnostic services, collecting and analyzing data, and providing training and education. The Advisory Council for the Elimination of Tuberculosis has prepared this report to provide a national standard by which policymakers, TB control program managers, and others evaluating TB programs can assess individual TB control programs

  11. Essential Learnings in Environmental Education--A Database for Building Activities and Programs.

    ERIC Educational Resources Information Center

    Ballard, Melissa, Comp.; Pandya, Mamata, Comp.

    The purpose of this book is to provide building blocks for designing and reviewing environmental education programs and activities. This handbook provides 600 basic concepts needed to attain the environmental education goals outlined at the Tbilisi, USSR, conference and generally agreed to be the fundamental core of quality environmental…

  12. Assessment Is Essential for Implementing Successful First-Year Experience Programs

    ERIC Educational Resources Information Center

    Dolinsky, Beverly; Matthews, Roberta S.; Greenfield, Gerald M.; Curtis-Tweed, Phyllis; Evenbeck, Scott E.

    2007-01-01

    Creating a climate of assessment is critical for fostering institutional change. This article discusses the authors' work in the Foundations of Excellence in the First College Year project, which has confirmed (across very different campuses) the centrality of assessment in the development and implementation of successful programs to strengthen…

  13. Postsecondary Disability Program Standards and Performance Indicators: Minimum Essentials for the Office for Students with Disabilities

    ERIC Educational Resources Information Center

    Shaw, Stan F.; Dukes, Lyman L., III

    2006-01-01

    The development and dissemination of Program Standards and Performance Indicators for disability services in higher education provides research-based direction for postsecondary institutions, consumers and governmental agencies with respect to the services necessary to provide equal access for college students with disabilities. Twenty-eight…

  14. Determining the "Essentials" for an Undergraduate Sustainability Degree Program: A Delphi Study at Dalhousie University

    ERIC Educational Resources Information Center

    Wright, Tarah S. A.; DeFields, Danielle

    2012-01-01

    Fostering a deep understanding of sustainability in students is critical in order to create a new generation of leaders. Universities have a significant role to play in this endeavour. Dalhousie University has recently developed the Environment, Sustainability and Society (ESS) program, which gives students the opportunity to study sustainability…

  15. An Essential Academic Program: A Case Study of the General Studies Program at Louisiana State University in Shreveport

    ERIC Educational Resources Information Center

    McCray, Lonnie

    2011-01-01

    The purpose of this study was to provide a historical overview of the development of the General Studies (GS) program at LSU Shreveport from its inception in 1967 until 2007. Sources of data were primary, secondary, and archival documents, student information accessed through the university mainframe, alumni information obtained from a…

  16. PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells.

    PubMed

    Han, Haibo; Du, Yantao; Zhao, Wei; Li, Sheng; Chen, Dongji; Zhang, Jing; Liu, Jiang; Suo, Zhenhe; Bian, Xiuwu; Xing, Baocai; Zhang, Zhiqian

    2015-01-01

    Tumour-initiating cells (TICs) are advocated to constitute the sustaining force to maintain and renew fully established malignancy; however, the molecular mechanisms responsible for these properties are elusive. We previously demonstrated that voltage-gated calcium channel α2δ1 subunit marks hepatocellular carcinoma (HCC) TICs. Here we confirm directly that α2δ1 is a HCC TIC surface marker, and identify let-7c, miR-200b, miR-222 and miR-424 as suppressors of α2δ1(+) HCC TICs. Interestingly, all the four miRNAs synergistically target PBX3, which is sufficient and necessary for the acquisition and maintenance of TIC properties. Moreover, PBX3 drives an essential transcriptional programme, activating the expression of genes critical for HCC TIC stemness including CACNA2D1, EpCAM, SOX2 and NOTCH3. In addition, the expression of CACNA2D1 and PBX3 mRNA is predictive of poor prognosis for HCC patients. Collectively, our study identifies an essential signalling pathway that controls the switch of HCC TIC phenotypes. PMID:26420065

  17. Effects of Comprehensive, Multiple High-Risk Behaviors Prevention Program on High School Students

    ERIC Educational Resources Information Center

    Collier, Crystal

    2013-01-01

    The purpose of this mixed methods study was to examine the effect of a multiple high-risk behaviors prevention program applied comprehensively throughout an entire school-system involving universal, selective, and indicated levels of students at a local private high school during a 4-year period. The prevention program was created based upon the…

  18. A FORTRAN IV Program for Multiple-choice Tests with Predetermined Minimal Acceptable Performance Levels

    ERIC Educational Resources Information Center

    Noe, Michael J.

    1976-01-01

    A Fortran IV multiple choice test scoring program for an IBM 370 computer is described that computes minimally acceptable performance levels and compares student scores to these levels. The program accomodates up to 500 items with no more than nine alternatives from a group of examinees numbering less than 10,000. (Author)

  19. A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.

    PubMed

    Commichau, Fabian M; Dickmanns, Achim; Gundlach, Jan; Ficner, Ralf; Stülke, Jörg

    2015-07-01

    Second messengers are key components of many signal transduction pathways. In addition to cyclic AMP, ppGpp and cyclic di-GMP, many bacteria use also cyclic di-AMP as a second messenger. This molecule is synthesized by distinct classes of diadenylate cyclases and degraded by phosphodiesterases. The control of the intracellular c-di-AMP pool is very important since both a lack of this molecule and its accumulation can inhibit growth of the bacteria. In many firmicutes, c-di-AMP is essential, making it the only known essential second messenger. Cyclic di-AMP is implicated in a variety of functions in the cell, including cell wall metabolism, potassium homeostasis, DNA repair and the control of gene expression. To understand the molecular mechanisms behind these functions, targets of c-di-AMP have been identified and characterized. Interestingly, c-di-AMP can bind both proteins and RNA molecules. Several proteins that interact with c-di-AMP are required to control the intracellular potassium concentration. In Bacillus subtilis, c-di-AMP also binds a riboswitch that controls the expression of a potassium transporter. Thus, c-di-AMP is the only known second messenger that controls a biological process by interacting with both a protein and the riboswitch that regulates its expression. Moreover, in Listeria monocytogenes c-di-AMP controls the activity of pyruvate carboxylase, an enzyme that is required to replenish the citric acid cycle. Here, we review the components of the c-di-AMP signaling system. PMID:25869574

  20. Establishing an Integrative Medicine Program Within an Academic Health Center: Essential Considerations.

    PubMed

    Eisenberg, David M; Kaptchuk, Ted J; Post, Diana E; Hrbek, Andrea L; O'Connor, Bonnie B; Osypiuk, Kamila; Wayne, Peter M; Buring, Julie E; Levy, Donald B

    2016-09-01

    Integrative medicine (IM) refers to the combination of conventional and "complementary" medical services (e.g., chiropractic, acupuncture, massage, mindfulness training). More than half of all medical schools in the United States and Canada have programs in IM, and more than 30 academic health centers currently deliver multidisciplinary IM care. What remains unclear, however, is the ideal delivery model (or models) whereby individuals can responsibly access IM care safely, effectively, and reproducibly in a coordinated and cost-effective way.Current models of IM across existing clinical centers vary tremendously in their organizational settings, principal clinical focus, and services provided; practitioner team composition and training; incorporation of research activities and educational programs; and administrative organization (e.g., reporting structure, use of medical records, scope of clinical practice) and financial strategies (i.e., specific business plans and models for sustainability).In this article, the authors address these important strategic issues by sharing lessons learned from the design and implementation of an IM facility within an academic teaching hospital, the Brigham and Women's Hospital at Harvard Medical School; and review alternative options based on information about IM centers across the United States.The authors conclude that there is currently no consensus as to how integrative care models should be optimally organized, implemented, replicated, assessed, and funded. The time may be right for prospective research in "best practices" across emerging models of IM care nationally in an effort to standardize, refine, and replicate them in preparation for rigorous cost-effectiveness evaluations. PMID:27028029

  1. Low-dose computed tomography screening for lung cancer in a clinical setting: essential elements of a screening program.

    PubMed

    McKee, Brady J; McKee, Andrea B; Kitts, Andrea Borondy; Regis, Shawn M; Wald, Christoph

    2015-03-01

    The purpose of this article is to review clinical computed tomography (CT) lung screening program elements essential to safely and effectively manage the millions of Americans at high risk for lung cancer expected to enroll in lung cancer screening programs over the next 3 to 5 years. To optimize the potential net benefit of CT lung screening and facilitate medical audits benchmarked to national quality standards, radiologists should interpret these examinations using a validated structured reporting system such as Lung-RADS. Patient and physician educational outreach should be enacted to support an informed and shared decision-making process without creating barriers to screening access. Programs must integrate smoking cessation interventions to maximize the clinical efficacy and cost-effectiveness of screening. At an institutional level, budgets should account for the necessary expense of hiring and/or training qualified support staff and equipping them with information technology resources adequate to enroll and track patients accurately over decades of future screening evaluation. At a national level, planning should begin on ways to accommodate the upcoming increased demand for physician services in fields critical to the success of CT lung screening such as diagnostic radiology and thoracic surgery. Institutions with programs that follow these specifications will be well equipped to meet the significant oncoming demand for CT lung screening services and bestow clinical benefits on their patients equal to or beyond what was observed in the National Lung Screening Trial. PMID:25658476

  2. Autographa californica multiple nucleopolyhedrovirus ac142, a core gene that is essential for BV production and ODV envelopment

    SciTech Connect

    McCarthy, Christina B.; Da, Xiaojiang; Donly, Cam; Theilmann, David A.

    2008-03-15

    Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac142 is a baculovirus core gene and encodes a protein previously shown to associate with occlusion-derived virus (ODV). To determine its role in the baculovirus life cycle, we used the AcMNPV bacmid system to generate an ac142 deletion virus (AcBAC{sup ac142KO-PH-GFP}). Fluorescence and light microscopy revealed that AcBAC{sup ac142KO-PH-GFP} exhibits a single-cell infection phenotype. Titration assays and Western blot confirmed that AcBAC{sup ac142KO-PH-GFP} is unable to produce budded virus (BV). However, viral DNA replication is unaffected and the development of occlusion bodies in AcBAC{sup ac142KO-PH-GFP}-transfected cells evidenced progression to very late phases of the viral infection. Western blot analysis showed that AC142 is expressed in the cytoplasm and nucleus throughout infection and that it is a structural component of BV and ODV which localizes to nucleocapsids. Electron microscopy indicates that ac142 is required for nucleocapsid envelopment to form ODV and their subsequent occlusion, a fundamental process to all baculoviruses.

  3. Metabolic programming mediated by an essential fatty acid alters body composition and survival skills of a marine fish.

    PubMed

    Fuiman, Lee A; Perez, Kestrel O

    2015-11-22

    Metabolic programming occurs when variations in nutrition during a specific developmental window result in long-term metabolic effects. It has been studied almost exclusively in humans and other mammals but never in an ecological context. Here, we report metabolic programming and its functional consequences in a marine fish, red drum. We demonstrate that maternal provisioning of eggs with an essential fatty acid, docosahexaenoic acid (DHA), varies with DHA content of the maternal diet. When offspring are reared on a DHA-replete diet, whole-body DHA content of offspring depends upon the amount of DHA that was in the egg. We further demonstrate that whole-body DHA content is correlated with traits related to offspring fitness (escape responses, routine swimming, growth, and survival). DHA content of red drum eggs produced in nature is in the range where the effects of metabolic programming are most pronounced. Our findings indicate that during a brief developmental window, DHA plays a role in establishing the metabolic capacity for its own uptake or storage, with protracted and possibly permanent effects on ecologically important survival skills of individuals and important implications for dynamics of populations and food webs. PMID:26582018

  4. Generating and executing programs for a floating point single instruction multiple data instruction set architecture

    DOEpatents

    Gschwind, Michael K

    2013-04-16

    Mechanisms for generating and executing programs for a floating point (FP) only single instruction multiple data (SIMD) instruction set architecture (ISA) are provided. A computer program product comprising a computer recordable medium having a computer readable program recorded thereon is provided. The computer readable program, when executed on a computing device, causes the computing device to receive one or more instructions and execute the one or more instructions using logic in an execution unit of the computing device. The logic implements a floating point (FP) only single instruction multiple data (SIMD) instruction set architecture (ISA), based on data stored in a vector register file of the computing device. The vector register file is configured to store both scalar and floating point values as vectors having a plurality of vector elements.

  5. Reliable and efficient program for fitting Galatry and Voigt profiles to spectral data on multiple lines.

    PubMed

    Ouyang, X; Varghese, P L

    1989-04-15

    Experimental data with multiple overlapping spectral lines must often be fitted to theoretical line shape models. This paper describes an efficient program for performing least-squares fits of such data to Galatry and Voigt profiles. The algorithm and program design considerations are presented in detail, and some examples are given to demonstrate its use. The procedure described in this paper may also be used for more complex line shape profiles. PMID:20548696

  6. Essential Elements of an Academic Program for Whatcom County Public School Students Challenged with Social/Emotional and/or Chronic Mental Health Disorders

    ERIC Educational Resources Information Center

    Jewell-Jenkins, Carolyn

    2009-01-01

    This study identifies essential program elements for Whatcom Discovery Center, a Northwest Educational Service District cooperative program providing academic and social/emotional development services to students who are challenged with severe social/emotional and/or chronic mental health disorders. The seven (7) Superintendents and seven (7)…

  7. Multiple Intelligences Theory and Foreign Language Education: Perspectives of College Students in a German Immersion Program

    ERIC Educational Resources Information Center

    Weber-Segler, Ellen

    2013-01-01

    The purpose of this qualitative research study was to explore and comprehend the role of Howard Gardner's theory of multiple intelligences (MI) in foreign language learning by analyzing the perspectives of college students in a German immersion program at a liberal arts college in the Midwest. Data collection included 10 in-depth student…

  8. 42 CFR 2.34 - Disclosures to prevent multiple enrollments in detoxification and maintenance treatment programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Disclosures to prevent multiple enrollments in detoxification and maintenance treatment programs. 2.34 Section 2.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE...

  9. Applying Multiple Intelligences Theory in Preservice and Inservice TEFL Education Programs.

    ERIC Educational Resources Information Center

    Christison, Mary Ann

    1998-01-01

    Discusses Gardner's theory of multiple intelligences (MI) and its integration in teaching English-as-a-Foreign-Language (TEFL) teacher-education programs. Four steps for introducing EFL teachers to MI theory are provided: introduce the basic theory; use an MI inventory; categorize familiar EFL activities; conduct a personal audit of…

  10. Evaluation of a preschool nutrition education program based on the theory of multiple intelligences.

    PubMed

    Cason, K L

    2001-01-01

    This report describes the evaluation of a preschool nutrition education program based on the theory of multiple intelligences. Forty-six nutrition educators provided a series of 12 lessons to 6102 preschool-age children. The program was evaluated using a pretest/post-test design to assess differences in fruit and vegetable identification, healthy snack choices, willingness to taste foods, and eating behaviors. Subjects showed significant improvement in food identification and recognition, healthy snack identification, willingness to taste foods, and frequency of fruit, vegetable, meat, and dairy consumption. The evaluation indicates that the program was an effective approach for educating preschool children about nutrition. PMID:11953232

  11. User's Guide to the Weighted-Multiple-Linear Regression Program (WREG version 1.0)

    USGS Publications Warehouse

    Eng, Ken; Chen, Yin-Yu; Kiang, Julie.E.

    2009-01-01

    Streamflow is not measured at every location in a stream network. Yet hydrologists, State and local agencies, and the general public still seek to know streamflow characteristics, such as mean annual flow or flood flows with different exceedance probabilities, at ungaged basins. The goals of this guide are to introduce and familiarize the user with the weighted multiple-linear regression (WREG) program, and to also provide the theoretical background for program features. The program is intended to be used to develop a regional estimation equation for streamflow characteristics that can be applied at an ungaged basin, or to improve the corresponding estimate at continuous-record streamflow gages with short records. The regional estimation equation results from a multiple-linear regression that relates the observable basin characteristics, such as drainage area, to streamflow characteristics.

  12. Application of gas-liquid chromatography to the analysis of essential oils. Part XVII. Fingerprinting of essential oils by temperature-programmed gas-liquid chromatography using capillary columns with non-polar stationary phases. Analytical methods committee.

    PubMed

    1997-10-01

    Problems in obtaining reproducible results when 'fingerprinting' essential oils by temperature-programmed gas-liquid chromatography have been reported on in Parts VII and VIII of this series. Those reports were concerned with the general problems and the use of packed columns. This report is concerned with the use of capillary columns and non-polar stationary phases. A collaborative study using capillary columns with non-polar stationary phases has resulted in a method which specifies the 'g-pack value' of a column and gives reproducible relative retention indices for the test compounds limonene, acetophenone, linalol, naphthalene, linalyl acetate and cinnamyl alcohol. The method has been applied successfully to the examination of oil of rosemary. A recommended method is given for the reproducible temperature-programmed gas-liquid chromatographic fingerprinting of essential oils using capillary columns with non-polar stationary phases. PMID:9463975

  13. National Dissemination of Multiple Evidence-Based Disease Prevention Programs: Reach to Vulnerable Older Adults

    PubMed Central

    Towne, Samuel D.; Smith, Matthew Lee; Ahn, SangNam; Altpeter, Mary; Belza, Basia; Kulinski, Kristie Patton; Ory, Marcia G.

    2015-01-01

    Older adults, who are racial/ethnic minorities, report multiple chronic conditions, reside in medically underserved rural areas, or have low incomes carry a high burden of chronic illness but traditionally lack access to disease prevention programs. The Chronic Disease Self-Management Program (CDSMP), A Matter of Balance/Volunteer Lay Leader (AMOB/VLL), and EnhanceFitness (EF) are widely disseminated evidence-based programs (EBP), but the extent to which they are simultaneously delivered in communities to reach vulnerable populations has not been documented. We conducted cross-sectional analyses of three EBP disseminated within 27 states throughout the United States (US) (2006–2009) as part of the Administration on Aging (AoA) Evidence-Based Disease and Disability Prevention Initiative, which received co-funding from the Atlantic Philanthropies. This study measures the extent to which CDSMP, AMOB/VLL, and EF reached vulnerable older adults. It also examines characteristics of communities offering one of these programs relative to those simultaneously offering two or all three programs. Minority/ethnic participants represented 38% for CDSMP, 26% for AMOB/VLL, and 43% for EF. Rural participation was 18% for CDSMP, 17% for AMOB/VLL, and 25% for EF. Those with comorbidities included 63.2% for CDSMP, 58.7% for AMOB/VLL, and 63.6% for EF while approximately one-quarter of participants had incomes under $15,000 for all programs. Rural areas and health professional shortage areas (HPSA) tended to deliver fewer EBP relative to urban areas and non-HPSA. These EBP attract diverse older adult participants. Findings highlight the capability of communities to serve potentially vulnerable older adults by offering multiple EBP. Because each program addresses unique issues facing this older population, further research is needed to better understand how communities can introduce, embed, and sustain multiple EBP to ensure widespread access and utilization, especially to

  14. Barriers and Facilitators Related to Participation in Aquafitness Programs for People with Multiple Sclerosis

    PubMed Central

    Kitchen, Kaitlyn; Nicoll, Kaley

    2012-01-01

    Exercise and leisure activities provide physical and psychosocial benefits to people with multiple sclerosis (MS) and can enhance their quality of life. In Winnipeg, Manitoba, Canada, people with MS have reported barriers to their participation in local MS-specific aquafitness (AF) programs. Therefore, a formal exploration of the accessibility of local AF programs for people with MS was undertaken. The purpose of this phenomenological study was to identify factors that facilitate or impede participation in AF programs by individuals with MS living in Winnipeg. Qualitative data were collected from a total of eight participants through one focus group (n = 7) and one in-depth interview (n = 1). The sample consisted of individuals with MS who were currently participating in AF programming as well as those who were not. Data were audio-recorded and transcribed verbatim, and thematic analysis was completed. Seven themes emerged regarding factors affecting participation in local AF programs. Barriers to participation included inadequate transportation, lack of one-on-one support, environmental inaccessibility, and fears associated with participation in the programs. Facilitators of participation included a knowledgeable instructor and experiencing physical and psychosocial benefits from the program. Information from this study was used locally to advocate for people with MS in order to increase participation in local AF programming. PMID:24453744

  15. An Extension of the StarSs Programming Model for Platforms with Multiple GPUs

    NASA Astrophysics Data System (ADS)

    Ayguadé, Eduard; Badia, Rosa M.; Igual, Francisco D.; Labarta, Jesús; Mayo, Rafael; Quintana-Ortí, Enrique S.

    While general-purpose homogeneous multi-core architectures are becoming ubiquitous, there are clear indications that, for a number of important applications, a better performance/power ratio can be attained using specialized hardware accelerators. These accelerators require specific SDK or programming languages which are not always easy to program. Thus, the impact of the new programming paradigms on the programmer’s productivity will determine their success in the high-performance computing arena. In this paper we present GPU Superscalar (GPUSs), an extension of the Star Superscalar programming model that targets the parallelization of applications on platforms consisting of a general-purpose processor connected with multiple graphics processors. GPUSs deals with architecture heterogeneity and separate memory address spaces, while preserving simplicity and portability. Preliminary experimental results for a well-known operation in numerical linear algebra illustrate the correct adaptation of the runtime to a multi-GPU system, attaining notable performance results.

  16. Application of Item Analysis to Assess Multiple-Choice Examinations in the Mississippi Master Cattle Producer Program

    ERIC Educational Resources Information Center

    Parish, Jane A.; Karisch, Brandi B.

    2013-01-01

    Item analysis can serve as a useful tool in improving multiple-choice questions used in Extension programming. It can identify gaps between instruction and assessment. An item analysis of Mississippi Master Cattle Producer program multiple-choice examination responses was performed to determine the difficulty of individual examinations, assess the…

  17. Perceived Impact of a Self-Management Program for Fatigue in Multiple Sclerosis

    PubMed Central

    Wilkinson, Amanda; Snowdon, Jessie

    2016-01-01

    Background: Fatigue in multiple sclerosis (MS) is reported to be one of its most debilitating symptoms, affecting personal, family, and community participation. Despite a high incidence of MS in New Zealand, there was no cohesive approach to support people with MS to manage their fatigue. This prompted the development of Minimise Fatigue, Maximise Life: Creating Balance with Multiple Sclerosis (MFML), a group-based, 6-week fatigue self-management program. This study explored the perceived impact of MFML for participants who attended the program. Methods: We undertook semistructured individual telephone interviews 1 (n = 23) and 3 (n = 11) months after delivery of the program. Data were analyzed for themes. Results: Two themes emerged from the data: achieving behavior change to manage fatigue and whole of life effects. These themes represent participants' perceived benefits of the program. Conclusions: This study provides evidence that the MFML fatigue self-management program positively affected the lives of participants. The findings suggest that participants had begun to successfully develop and integrate self-management skills into their everyday lives. This affected the individual personally and also their participation in family and community life. This study adds to the current knowledge and understanding of the positive effect that delivery of a fatigue self-management intervention can have for people with MS. PMID:26917995

  18. Astronomical Association of Queensland Program of Measurements of Seven Southern Multiple Stars

    NASA Astrophysics Data System (ADS)

    Jenkinson, Graeme

    2016-04-01

    This paper presents the results of a mid-2014 program of the Astronomical Association of Queensland of photographic measurements of seven southern multiple stars. The images were obtained using a Meade DSI CCD camera in conjunction with an equatorially mounted 150mm F8 refractor. For each target pair, either a 2x or 5x barlow lens was used as required. Image processing was carried out using Losse's REDUC software.

  19. A Telerehabilitation Program Improves Postural Control in Multiple Sclerosis Patients: A Spanish Preliminary Study

    PubMed Central

    Ortiz-Gutiérrez, Rosa; Cano-de-la-Cuerda, Roberto; Galán-del-Río, Fernando; Alguacil-Diego, Isabel María; Palacios-Ceña, Domingo; Miangolarra-Page, Juan Carlos

    2013-01-01

    Postural control disorders are among the most frequent motor disorder symptoms associated with multiple sclerosis. This study aims to demonstrate the potential improvements in postural control among patients with multiple sclerosis who complete a telerehabilitation program that represents a feasible alternative to physical therapy for situations in which conventional treatment is not available. Fifty patients were recruited. Control group (n = 25) received physiotherapy treatment twice a week (40 min per session). Experimental group (n = 25) received monitored telerehabilitation treatment via videoconference using the Xbox 360® and Kinect console. Experimental group attended 40 sessions, four sessions per week (20 min per session).The treatment schedule lasted 10 weeks for both groups. A computerized dynamic posturography (Sensory Organization Test) was used to evaluate all patients at baseline and at the end of the treatment protocol. Results showed an improvement over general balance in both groups. Visual preference and the contribution of vestibular information yielded significant differences in the experimental group. Our results demonstrated that a telerehabilitation program based on a virtual reality system allows one to optimize the sensory information processing and integration systems necessary to maintain the balance and postural control of people with multiple sclerosis. We suggest that our virtual reality program enables anticipatory PC and response mechanisms and might serve as a successful therapeutic alternative in situations in which conventional therapy is not readily available. PMID:24185843

  20. Directory of Evaluation Training Programs.

    ERIC Educational Resources Information Center

    May, Ralph M.; And Others

    1986-01-01

    Descriptions of 48 evaluation training programs offered by colleges and universities are organized into five major divisions: postdoctoral training, doctoral training, master's training, specialist training, and multiple programs. Essential characteristics, placement statistics, admission requirements, and curriculum descriptions are listed. (BS)

  1. Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and Mice.

    PubMed

    Shaheen, Ranad; Anazi, Shams; Ben-Omran, Tawfeg; Seidahmed, Mohammed Zain; Caddle, L Brianna; Palmer, Kristina; Ali, Rehab; Alshidi, Tarfa; Hagos, Samya; Goodwin, Leslie; Hashem, Mais; Wakil, Salma M; Abouelhoda, Mohamed; Colak, Dilek; Murray, Stephen A; Alkuraya, Fowzan S

    2016-04-01

    Nonsense-mediated decay (NMD) is an important process that is best known for degrading transcripts that contain premature stop codons (PTCs) to mitigate their potentially harmful consequences, although its regulatory role encompasses other classes of transcripts as well. Despite the critical role of NMD at the cellular level, our knowledge about the consequences of deficiency of its components at the organismal level is largely limited to model organisms. In this study, we report two consanguineous families in which a similar pattern of congenital anomalies was found to be most likely caused by homozygous loss-of-function mutations in SMG9, encoding an essential component of the SURF complex that generates phospho-UPF1, the single most important step in NMD. By knocking out Smg9 in mice via CRISPR/Cas9, we were able to recapitulate the major features of the SMG9-related multiple congenital anomaly syndrome we observed in humans. Surprisingly, human cells devoid of SMG9 do not appear to have reduction of PTC-containing transcripts but do display global transcriptional dysregulation. We conclude that SMG9 is required for normal human and murine development, most likely through a transcriptional regulatory role, the precise nature of which remains to be determined. PMID:27018474

  2. The SI-Combiner: Making sense of results from multiple trained programs

    SciTech Connect

    Den Hartog, B.K.; Elling, J.W.; Kieckhafer, R.

    1998-12-31

    Many problems, such as Aroclor Interpretation, are ill-conditioned problems in which trained programs, or methods, must operate in scenarios outside their training ranges because it is intractable to train them completely. Consequently, they fail in ways related to the scenarios. Importantly, when multiple trained methods fail divergently, their patterns of failures provide insights into the true results. The SI-Combiner solves this problem of Integrating Multiple learned Models (IMLM) by automatically learning and using these insights to produce a solution more accurate than any single trained program. In application, the Aroclor Interpretation SI-Combiner improved on the accuracy of the most accurate individual trained program in the suite. This paper presents a new fuzzy IMLM method called the SI-Combiner and its application to Aroclor Interpretation. Additionally, this paper shows the improvement in accuracy that the SI-Combiner`s components show against Multicategory Classification (MCC), Dempster-Shafer (DS), and the best individual trained program in the Aroclor Interpretation suite (iMLR).

  3. Calculator programs to deal with non-steady state, multiple dosage regimen clinical pharmacokinetics.

    PubMed

    Ensom, R J; Nakagawa, R S

    1983-07-01

    Serum drug levels have become a useful tool in the optimization of dosage requirements for several therapeutically important drugs. In the acute care situation the interpretation of these levels is complicated by multiple dosage regimens and inadequate time to achieve steady-state serum drug levels. Mathematical equations describing first order single compartment pharmacokinetics have been compiled. An alpha-numeric programmable calculator has been programmed to accept information regarding up to seven different serial dosage regimens. The calculator is also programmed to predict concentrations at any time during a complex set of dosage regimens or peak, trough, and average concentrations given a maintenance dosage regimen. Examples are given to demonstrate the usefulness of the programs in the clinical setting. PMID:6688607

  4. Character Development within Youth Development Programs: Exploring Multiple Dimensions of Activity Involvement.

    PubMed

    Lynch, Alicia Doyle; Ferris, Kaitlyn A; Burkhard, Brian; Wang, Jun; Hershberg, Rachel M; Lerner, Richard M

    2016-03-01

    We examined links among three dimensions of youth involvement (intensity, duration, and engagement) in Boy Scouts of America (BSA), an international out-of-school time (OST) youth development program designed to promote moral and performance character in boys. Using data from 737 youth and their parents who participated in one of 40 BSA program sites (commonly referred to as "packs"), we first considered how individual- and pack-level measures of program involvement were differentially linked with character development. Next, we examined whether pack-level involvement characteristics moderate individual-level involvement characteristics, hypothesizing that highly involved packs would serve to further enhance the positive effects of high levels of individual involvement. Results indicated engagement was the strongest, most frequent predictor of increases in both moral and performance character. Although there were no direct effects of pack-level intensity, duration, or engagement, the effects of individual-level engagement were moderated by pack-level engagement, suggesting that the largest increases in moral and performance character occurred among highly engaged youth who were enrolled in highly engaged packs. These results highlight the need to examine multiple dimensions of OST program involvement simultaneously, and suggest that strengthening youth engagement in programming may provide a means for enhancing the positive effects of high-quality youth programming. PMID:27217313

  5. Sequential multiple assignment randomized trial (SMART) with adaptive randomization for quality improvement in depression treatment program.

    PubMed

    Cheung, Ying Kuen; Chakraborty, Bibhas; Davidson, Karina W

    2015-06-01

    Implementation study is an important tool for deploying state-of-the-art treatments from clinical efficacy studies into a treatment program, with the dual goals of learning about effectiveness of the treatments and improving the quality of care for patients enrolled into the program. In this article, we deal with the design of a treatment program of dynamic treatment regimens (DTRs) for patients with depression post-acute coronary syndrome. We introduce a novel adaptive randomization scheme for a sequential multiple assignment randomized trial of DTRs. Our approach adapts the randomization probabilities to favor treatment sequences having comparatively superior Q-functions used in Q-learning. The proposed approach addresses three main concerns of an implementation study: it allows incorporation of historical data or opinions, it includes randomization for learning purposes, and it aims to improve care via adaptation throughout the program. We demonstrate how to apply our method to design a depression treatment program using data from a previous study. By simulation, we illustrate that the inputs from historical data are important for the program performance measured by the expected outcomes of the enrollees, but also show that the adaptive randomization scheme is able to compensate poorly specified historical inputs by improving patient outcomes within a reasonable horizon. The simulation results also confirm that the proposed design allows efficient learning of the treatments by alleviating the curse of dimensionality. PMID:25354029

  6. The Effects of Visual Cues and Learners' Field Dependence in Multiple External Representations Environment for Novice Program Comprehension

    ERIC Educational Resources Information Center

    Wei, Liew Tze; Sazilah, Salam

    2012-01-01

    This study investigated the effects of visual cues in multiple external representations (MER) environment on the learning performance of novices' program comprehension. Program codes and flowchart diagrams were used as dual representations in multimedia environment to deliver lessons on C-Programming. 17 field independent participants and 16 field…

  7. A simple method to control over-alignment in the MAFFT multiple sequence alignment program

    PubMed Central

    Katoh, Kazutaka; Standley, Daron M.

    2016-01-01

    Motivation: We present a new feature of the MAFFT multiple alignment program for suppressing over-alignment (aligning unrelated segments). Conventional MAFFT is highly sensitive in aligning conserved regions in remote homologs, but the risk of over-alignment is recently becoming greater, as low-quality or noisy sequences are increasing in protein sequence databases, due, for example, to sequencing errors and difficulty in gene prediction. Results: The proposed method utilizes a variable scoring matrix for different pairs of sequences (or groups) in a single multiple sequence alignment, based on the global similarity of each pair. This method significantly increases the correctly gapped sites in real examples and in simulations under various conditions. Regarding sensitivity, the effect of the proposed method is slightly negative in real protein-based benchmarks, and mostly neutral in simulation-based benchmarks. This approach is based on natural biological reasoning and should be compatible with many methods based on dynamic programming for multiple sequence alignment. Availability and implementation: The new feature is available in MAFFT versions 7.263 and higher. http://mafft.cbrc.jp/alignment/software/ Contact: katoh@ifrec.osaka-u.ac.jp Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27153688

  8. Community Delivery of a Comprehensive Fall-Prevention Program in People with Multiple Sclerosis

    PubMed Central

    Frankel, Debra; Tompkins, Sara A.; Cameron, Michelle

    2016-01-01

    Background: People with multiple sclerosis (MS) fall frequently. In 2011, the National Multiple Sclerosis Society launched a multifactorial fall-prevention group exercise and education program, Free From Falls (FFF), to prevent falls in MS. The objective of this study was to assess the impact of participation in the FFF program on balance, mobility, and falls in people with MS. Methods: This was a retrospective evaluation of assessments from community delivery of FFF. Changes in Activities-specific Balance Confidence scale scores, Berg Balance Scale scores, 8-foot Timed Up and Go performance, and falls were assessed. Results: A total of 134 participants completed the measures at the first and last FFF sessions, and 109 completed a 6-month follow-up assessment. Group mean scores on the Activities-specific Balance Confidence scale (F1,66 = 17.14, P < .05, η2 = 0.21), Berg Balance Scale (F1,68 = 23.39, P < .05, η2 = 0.26), and 8-foot Timed Up and Go (F1,79 = 4.83, P < .05, η2 = 0.06) all improved significantly from the first to the last session. At the 6-month follow-up, fewer falls were reported (χ2 [4, N = 239] = 10.56, P < .05, Phi = 0.21). Conclusions: These observational data suggest that the FFF group education and exercise program improves balance confidence, balance performance, and functional mobility and reduces falls in people with MS. PMID:26917997

  9. Comparing routine neurorehabilitation program with trunk exercises based on Bobath concept in multiple sclerosis: pilot study.

    PubMed

    Keser, Ilke; Kirdi, Nuray; Meric, Aydin; Kurne, Asli Tuncer; Karabudak, Rana

    2013-01-01

    This study compared trunk exercises based on the Bobath concept with routine neurorehabilitation approaches in multiple sclerosis (MS). Bobath and routine neurorehabilitation exercises groups were evaluated. MS cases were divided into two groups. Both groups joined a 3 d/wk rehabilitation program for 8 wk. The experimental group performed trunk exercises based on the Bobath concept, and the control group performed routine neurorehabilitation exercises. Additionally, both groups performed balance and coordination exercises. All patients were evaluated with the Trunk Impairment Scale (TIS), Berg Balance Scale (BBS), International Cooperative Ataxia Rating Scale (ICARS), and Multiple Sclerosis Functional Composite (MSFC) before and after the physiotherapy program. In group analysis, TIS, BBS, ICARS, and MSFC scores and strength of abdominal muscles were significantly different after treatment in both groups (p < 0.05). When the groups were compared, no significant differences were found in any parameters (p > 0.05). Although trunk exercises based on the Bobath concept are rarely applied in MS rehabilitation, the results of this study show that they are as effective as routine neurorehabilitation exercises. Therefore, trunk exercises based on the Bobath concept can be beneficial in MS rehabilitation programs. PMID:23516089

  10. Evaluation of a Fatigue Self-Management Program for People with Multiple Sclerosis

    PubMed Central

    Wilkinson, Amanda; Barclay, Amelia; Whiting, Hayley; Heynike, Christelle; Snowdon, Jessie

    2016-01-01

    Background: Fatigue is one of the most common and debilitating symptoms of multiple sclerosis (MS). The program “Minimise Fatigue, Maximise Life: Creating Balance with Multiple Sclerosis” (MFML) was created in New Zealand because of the lack of a fatigue management program for people with MS in that country. This program aims to empower individuals with MS to manage their own symptoms of fatigue. The objective of this study was to evaluate the MFML fatigue self-management program. Methods: Self-report questionnaires were used to measure impact of fatigue (5-item Modified Fatigue Impact Scale), self-efficacy (MS Self-efficacy Scale), and quality of life (12-item Short Form Health Status Survey [SF-12]) 1 month before (T1), at commencement of (T2) (to investigate the stability of questionnaire scores before the intervention), and at the end of (T3) the 6-week group-based program. Increased self-efficacy and quality of life scores and a decrease in reported impact of fatigue were the anticipated primary outcomes, with participants acting as their own controls. Results: Twenty-five women (aged 37–63 years) participated. Stability of scores for all the questionnaires was evidenced between T1 and T2. After the intervention (T3), scores showed a significant improvement in self-efficacy and impact of fatigue, with large effect sizes, but no change in either the physical or mental component summary of the SF-12. Conclusions: Despite the small sample size, this study showed an organized approach to the management of fatigue for people living with MS, and its outcomes demonstrated benefits for participants. PMID:27252598

  11. Integrating multiple health behavior theories into program planning: the PER worksheet.

    PubMed

    Langlois, Marietta A; Hallam, Jeffrey S

    2010-03-01

    The foundation of a logic model or any theory-based planning model is the identification of the behavioral antecedents and the relationship of these variables to the target behavior. Applying theoretical concepts to specific behaviors and populations is often challenging for practitioners and program planning students. The challenge comes from the abstract definition of theoretical constructs, the duplication of similar constructs in multiple theories, and the need to combine multiple theories. To simplify the planning process when utilizing logic models and health behavior theory, we recommend the use of the PER Worksheet. The PER Worksheet is a planning tool that provides layman-term prompts for identifying health behavior antecedents. It encompasses five common health behavior theories-health belief model, theory of planned behavior, social cognitive theory, an ecological perspective, and transtheoretical model. The PER Worksheet is organized into three columns: Predisposing, Enabling, and Reinforcing factors, terms of the PRECEDE/PROCEED model. PMID:18552278

  12. Design of a multiple kernel learning algorithm for LS-SVM by convex programming.

    PubMed

    Jian, Ling; Xia, Zhonghang; Liang, Xijun; Gao, Chuanhou

    2011-06-01

    As a kernel based method, the performance of least squares support vector machine (LS-SVM) depends on the selection of the kernel as well as the regularization parameter (Duan, Keerthi, & Poo, 2003). Cross-validation is efficient in selecting a single kernel and the regularization parameter; however, it suffers from heavy computational cost and is not flexible to deal with multiple kernels. In this paper, we address the issue of multiple kernel learning for LS-SVM by formulating it as semidefinite programming (SDP). Furthermore, we show that the regularization parameter can be optimized in a unified framework with the kernel, which leads to an automatic process for model selection. Extensive experimental validations are performed and analyzed. PMID:21441012

  13. HANFORD SITE WELDING PROGRAM SUCCESSFULLY PROVIDING A SINGLE SITE FUNCTION FOR USE BY MULTIPLE CONTRACTORS

    SciTech Connect

    CANNELL GR

    2009-11-19

    The Department of Energy, Richland Operations (DOE-RL) recently restructured its Hanford work scope, awarding two new contracts over the past several months for a total of three contracts to manage the sites cleanup efforts. DOE-RL met with key contractor personnel prior to and during contract transition to ensure site welding activities had appropriate oversight and maintained code compliance. The transition also provided an opportunity to establish a single site-wide function that would provide welding and materials engineering services to the Hanford site contractors: CH2M HILL Plateau Remediation Company (CHPRC); Mission Support Alliance (MSA); Washington River Protection Solutions (WRPS); and Washington Closure Hanford (WCH). Over the years, multiple and separate welding programs (amongst the several contractors) existed at the Hanford site leading to inefficiencies resulting from duplication of administrative efforts, maintenance of welding procedures, welder performance certifications, etc. The new, single program eliminates these inefficiencies. The new program, co-managed by two of the sites' new contractors, the CHPRC ('owner' of the program and responsible for construction welding services) and the MSA (provides maintenance welding services), provides more than just the traditional construction and maintenance welding services. Also provided, are welding engineering, specialty welding development/qualification for the closure of radioactive materials containers and materials evaluation/failure analysis. The following describes the new Hanford site welding program.

  14. Applied electro-optics educational and training program with multiple entrance and exit pathways

    NASA Astrophysics Data System (ADS)

    Scott, Patricia; Zhou, Feng; Zilic, Dorothy

    2007-06-01

    This paper presents an innovative hands-on training program designed to create a pipeline of highly-skilled technical workers for today's workforce economy. The 2+2+2 Pennsylvania Integrated Workforce Leadership Program in Electro-Optics prepares students for a career in this new high-tech field. With seamless transition from high school into college, the program offers the versatility of multiple entrance and exit pathways. After completion of each educational level, students can exit the program with various skill levels, including certificates, an associate's degree, or a bachelor's degree. Launched by Indiana University of Pennsylvania (IUP) in partnership with Lenape Vocational School (Lenape), the 2+2+2 educational pathway program was implemented to promote early training of high-school students. During the first level, students in their junior and/or senior year enroll in four Electro-Optics courses at Lenape. Upon completion of these courses and an Advanced Placement Equivalency course with an appropriate exam score, students can earn a certificate from Lenape for the 15+ credits, which also can be articulated into IUP's associate degree program in Electro-Optics. During the second level, students can earn an associate's degree in Electro-Optics, offered only at the IUP Northpointe Campus. After completion of the Associate in Applied Science (A.A.S.), students are prepared to enter the workforce as senior technicians. During the third level, students who have completed the Associate of Science (A.S.) in Electro-Optics have the opportunity to matriculate at IUP's Indiana Campus to earn a Bachelor of Science (B.S.) degree in Applied Physics with a track in Electro-Optics. Hence, the name 2+2+2 refers to getting started in high school, continuing the educational experience with an associate's degree program, and optionally moving on to a bachelor's degree. Consequently, students move from one educational level to the next with advanced credits toward the next

  15. An improved multiple linear regression and data analysis computer program package

    NASA Technical Reports Server (NTRS)

    Sidik, S. M.

    1972-01-01

    NEWRAP, an improved version of a previous multiple linear regression program called RAPIER, CREDUC, and CRSPLT, allows for a complete regression analysis including cross plots of the independent and dependent variables, correlation coefficients, regression coefficients, analysis of variance tables, t-statistics and their probability levels, rejection of independent variables, plots of residuals against the independent and dependent variables, and a canonical reduction of quadratic response functions useful in optimum seeking experimentation. A major improvement over RAPIER is that all regression calculations are done in double precision arithmetic.

  16. Goals set after completing a teleconference-delivered program for managing multiple sclerosis fatigue.

    PubMed

    Asano, Miho; Preissner, Katharine; Duffy, Rose; Meixell, Maggie; Finlayson, Marcia

    2015-01-01

    Setting goals can be a valuable skill to self-manage multiple sclerosis (MS) fatigue. A better understanding of the goals set by people with MS after completing a fatigue management program can assist health care professionals with tailoring interventions for clients. This study aimed to describe the focus of goals set by people with MS after a teleconference-delivered fatigue management program and to evaluate the extent to which participants were able to achieve their goals over time. In total, 485 goals were set by 81 participants. Over a follow-up period, 64 participants rated 284 goals regarding progress made toward goal achievement. Approximately 50% of the rated goals were considered achieved. The most common type of goal achieved was that of instrumental activities of daily living. Short-term goals were more likely to be achieved. This study highlights the need for and importance of promoting and teaching goal-setting skills to people with MS. PMID:25871602

  17. A robust transcriptional program in newts undergoing multiple events of lens regeneration throughout their lifespan.

    PubMed

    Sousounis, Konstantinos; Qi, Feng; Yadav, Manisha C; Millán, José Luis; Toyama, Fubito; Chiba, Chikafumi; Eguchi, Yukiko; Eguchi, Goro; Tsonis, Panagiotis A

    2015-01-01

    Newts have the ability to repeatedly regenerate their lens even during ageing. However, it is unclear whether this regeneration reflects an undisturbed genetic activity. To answer this question, we compared the transcriptomes of lenses, irises and tails from aged newts that had undergone lens regeneration 19 times with the equivalent tissues from young newts that had never experienced lens regeneration. Our analysis indicates that repeatedly regenerated lenses showed a robust transcriptional program comparable to young never-regenerated lenses. In contrast, the tail, which was never regenerated, showed gene expression signatures of ageing. Our analysis strongly suggests that, with respect to gene expression, the regenerated lenses have not deviated from a robust transcriptional program even after multiple events of regeneration throughout the life of the newt. In addition, our study provides a new paradigm in biology, and establishes the newt as a key model for the study of regeneration in relation to ageing. PMID:26523389

  18. Autographa californica multiple nucleopolyhedrovirus ODV-E56 is a per os infectivity factor, but is not essential for binding and fusion of occlusion-derived virus to the host midgut

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) occlusion-derived virus (ODV) envelope protein ODV-E56 is essential for oral infection of neonate Heliothis virescens larvae. Here, we present a more detailed study of ODV-E56 function. Bioassays with recombinant clones of AcMNPV lack...

  19. Effects of Eight-week Resistance Training Program in Men With Multiple Sclerosis

    PubMed Central

    Moradi, Mahbubeh; Sahraian, Mohammad Ali; Aghsaie, Aida; Kordi, Mohammad Reza; Meysamie, Alipasha; Abolhasani, Maryam; Sobhani, Vahid

    2015-01-01

    Background: Muscle weakness and fatigue contribute to the reduction of daily activity in multiple sclerosis (MS) patients. Therapeutic strategies to promote improvements in muscle strength and endurance are limited in individuals with MS. Some evidence showed that exercise may improve and affect different aspects of the disease including quality of life, fatigue, motor and cognitive functions. Objectives: To investigate the value of resistance training of moderate to high intensity on motor function, muscle strength, balance and perceived disability in male patients with multiple sclerosis compared to a control group. Patients and Methods: 20 male patients with MS (mean ± SD, age: 34.05 ± 7.8 y; Expanded Disability Status Scale (EDSS): 2.94 ± 1.5) were recruited and randomized either to the exercise (E) or control group (C). Group E participated in a three-time weekly individualized progressive resistance-training program (both upper and lower extremities) for eight weeks, while group C was advised not to change their physical activity habits. All initial measures (including EDSS, balance, muscle strength, and functional mobility) were re-evaluated at the end of the program. Results: Two patients of group E left the program. The other eight subjects completed the program with no MS-related exacerbations/complications. There was a significant change in 2 of 3 aspects of ambulatory function [Three minutes step test (P = 0.001), Timed Up and Go test (P = 0.009)], muscle strength (P = 0.000), and EDSS (P = 0.014). Comparing the two groups, we did not observe any significant change in “Balance” (P = 0.407). Conclusions: The resistance training of moderate to high intensity was well-tolerated in MS patients and may be an effective intervention for improving muscle strength, functional ability and EDSS-based disease severity. PMID:26448834

  20. Research on a psychomotor program for children with severe motor or multiple disabilities.

    PubMed

    Nakken, H; den Ouden, W J

    1985-01-01

    This report deals with help for brain-injured children with severe motor or multiple disabilities. It is argued that these children lack experiences due to their motor-disabilities. On the basis of an analysis of psychomotor programs the program by Le Gay Brereton was chosen for further research. This program was judged to be suitable because it is designed for teaching disabled children in the preschool age and because it emphasizes interaction between teacher and child. The authors, however, did not follow all her recommendations. Three experimental studies on the effects of this program are reported here. A special topic is the construction and use of the evaluation instruments. These instruments were designed for evaluating individual changes. One instrument serves to evaluate the training process. The other one tests for changes in specific cognitive skills. A statistically significant improvement was reported in all three experiments. Finally the authors present a plan for further research which concentrates on formulating individual goals for the children and on an instruction method for teachers. PMID:3159695

  1. 77 FR 60439 - Notice of the Award of Single-Source Program Expansion Supplements to Multiple Grantees Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ...: Office of Family Assistance, ACF, HHS. ACTION: Award of single-source program expansion supplement grants to multiple grantees under the Office of Family Assistance's Health Profession Opportunity Grants program SUMMARY: This Administration for Children and Families (ACF), Office of Family Assistance...

  2. Mentoring from Different Social Spheres: How Can Multiple Mentors Help in Doctoral Student Success in Ed.D Programs?

    ERIC Educational Resources Information Center

    Terry, Tarae; Ghosh, Rajashi

    2015-01-01

    Doctoral students leave their programs early due to lack of mentoring relationships needed to support degree completion and success. However, how mentoring contributes to Ed.D degree completion is not widely studied. In this qualitative narrative study, we sought to explore how multiple mentoring relationships reduced attrition in an Ed.D program.…

  3. Educational Administration Candidates in Multiple-Roles as Evaluators, Learners and Consumers within a Principal Preparation Program

    ERIC Educational Resources Information Center

    Herrington, David E.

    2005-01-01

    This study highlights the value of leveraging department resources in principal preparation program resources to achieve multiple teaching and program review goals. In this study, masters degree candidates participated in all aspects of the evaluation of the Department of Educational Administration and Counseling. As consumers they already had a…

  4. A Fortran IV Program for Estimating Parameters through Multiple Matrix Sampling with Standard Errors of Estimate Approximated by the Jackknife.

    ERIC Educational Resources Information Center

    Shoemaker, David M.

    Described and listed herein with concomitant sample input and output is the Fortran IV program which estimates parameters and standard errors of estimate per parameters for parameters estimated through multiple matrix sampling. The specific program is an improved and expanded version of an earlier version. (Author/BJG)

  5. The sterol regulatory element binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

    PubMed Central

    Kidani, Yoko; Elsaesser, Heidi; Hock, M Benjamin; Vergnes, Laurent; Williams, Kevin J; Argus, Joseph P; Marbois, Beth N; Komisopoulou, Evangelia; Wilson, Elizabeth B; Osborne, Timothy F; Graeber, Thomas G; Reue, Karen; Brooks, David G; Bensinger, Steven J

    2013-01-01

    Newly activated CD8+ T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals mediating metabolic reprogramming remain poorly defined. Herein, we demonstrate an essential role for sterol regulatory element binding proteins (SREBPs) in the acquisition of effector cell metabolism. Without SREBP signaling, CD8+ T cells are unable to blast, resulting in markedly attenuated clonal expansion during viral infection. Mechanistic studies indicate that SREBPs are essential to meet the heightened lipid requirements of membrane synthesis during blastogenesis. SREBPs are dispensable for homeostatic proliferation, indicating a context-specific requirement for SREBPs in effector responses. These studies provide insights into the molecular signals underlying metabolic reprogramming of CD8+ T cells during the transition from quiescence to activation. PMID:23563690

  6. Waste management under multiple complexities: Inexact piecewise-linearization-based fuzzy flexible programming

    SciTech Connect

    Sun Wei; Huang, Guo H.; Lv Ying; Li Gongchen

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer Inexact piecewise-linearization-based fuzzy flexible programming is proposed. Black-Right-Pointing-Pointer It's the first application to waste management under multiple complexities. Black-Right-Pointing-Pointer It tackles nonlinear economies-of-scale effects in interval-parameter constraints. Black-Right-Pointing-Pointer It estimates costs more accurately than the linear-regression-based model. Black-Right-Pointing-Pointer Uncertainties are decreased and more satisfactory interval solutions are obtained. - Abstract: To tackle nonlinear economies-of-scale (EOS) effects in interval-parameter constraints for a representative waste management problem, an inexact piecewise-linearization-based fuzzy flexible programming (IPFP) model is developed. In IPFP, interval parameters for waste amounts and transportation/operation costs can be quantified; aspiration levels for net system costs, as well as tolerance intervals for both capacities of waste treatment facilities and waste generation rates can be reflected; and the nonlinear EOS effects transformed from objective function to constraints can be approximated. An interactive algorithm is proposed for solving the IPFP model, which in nature is an interval-parameter mixed-integer quadratically constrained programming model. To demonstrate the IPFP's advantages, two alternative models are developed to compare their performances. One is a conventional linear-regression-based inexact fuzzy programming model (IPFP2) and the other is an IPFP model with all right-hand-sides of fussy constraints being the corresponding interval numbers (IPFP3). The comparison results between IPFP and IPFP2 indicate that the optimized waste amounts would have the similar patterns in both models. However, when dealing with EOS effects in constraints, the IPFP2 may underestimate the net system costs while the IPFP can estimate the costs more accurately. The comparison results between IPFP and IPFP3 indicate

  7. Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.

    PubMed

    Solís, Eric J; Pandey, Jai P; Zheng, Xu; Jin, Dexter X; Gupta, Piyush B; Airoldi, Edoardo M; Pincus, David; Denic, Vladimir

    2016-07-01

    Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated with massive protein aggregation. Genome-wide analysis revealed that Hsf1 nuclear export immediately decreased basal transcription and mRNA expression of 18 genes, which predominately encode chaperones. Strikingly, rescuing basal expression of Hsp70 and Hsp90 chaperones enabled robust cell growth in the complete absence of Hsf1. With the exception of chaperone gene induction, the vast majority of the heat shock response was Hsf1 independent. By comparative analysis of mammalian cell lines, we found that only heat shock-induced but not basal expression of chaperones is dependent on the mammalian Hsf1 homolog (HSF1). Our work reveals that yeast chaperone gene expression is an essential housekeeping mechanism and provides a roadmap for defining the function of HSF1 as a driver of oncogenesis. PMID:27320198

  8. [Children with Multiple Risk Factor Exposition Benefit from the German "Strengthening Families Program"].

    PubMed

    Bröning, Sonja; Sack, Peter-Michael; Thomsen, Monika; Thomasius, Rainer

    2016-09-01

    Children with Multiple Risk Factor Exposition Benefit from the German "Strengthening Families Program" The German adaptation of the substance use-preventive family-based Strengthening Families Program 10-14 (SFP, Iowa version) was evaluated in a longitudinal two-year follow-up trial. Participants were N = 292 children with a mean age of twelve years at baseline, and N = 292 parents. We employed a multi-centric, randomized-controlled, two-armed (SFP vs. minimal control condition) study design. Following a "risk moderation hypothesis", we assumed that children with an elevated risk-exposition R(+) would benefit more than children with a low risk-exposition R(-) irrespective of the preventive intervention, and that R(+) under SFP would benefit more than R(+) under the minimal control condition. "Risk-exposition" was measured in correspondence with the Communities That Care Youth Survey-questionnaire. A total of 28 % of children were classified with an elevated risk level. Children's reports confirmed our hypothesis: R(+) report a total of eleven improvements, four of these being significantly more distinct than in the other groups (Anxiety-Depressivity, Punitive Parenting of mother, Punitive Parenting of father, Unbalanced family functioning). In three measures an improvement appears solely in R(+) under SFP (Satisfaction with family functioning, School Attachment and Peer Relationship Quality, Quality of Life). Parents' reports showed a similar tendency, but were less pronounced. PMID:27595812

  9. Faculty development programs improve the quality of Multiple Choice Questions items' writing

    PubMed Central

    Abdulghani, Hamza Mohammad; Ahmad, Farah; Irshad, Mohammad; Khalil, Mahmoud Salah; Al-Shaikh, Ghadeer Khalid; Syed, Sadiqa; Aldrees, Abdulmajeed Abdurrahman; Alrowais, Norah; Haque, Shafiul

    2015-01-01

    The aim of this study was to assess the utility of long term faculty development programs (FDPs) in order to improve the quality of multiple choice questions (MCQs) items' writing. This was a quasi-experimental study, conducted with newly joined faculty members. The MCQ items were analyzed for difficulty index, discriminating index, reliability, Bloom's cognitive levels, item writing flaws (IWFs) and MCQs' nonfunctioning distractors (NFDs) based test courses of respiratory, cardiovascular and renal blocks. Significant improvement was found in the difficulty index values of pre- to post-training (p = 0.003). MCQs with moderate difficulty and higher discrimination were found to be more in the post-training tests in all three courses. Easy questions were decreased from 36.7 to 22.5%. Significant improvement was also reported in the discriminating indices from 92.1 to 95.4% after training (p = 0.132). More number of higher cognitive level of Bloom's taxonomy was reported in the post-training test items (p<0.0001). Also, NFDs and IWFs were reported less in the post-training items (p<0.02). The MCQs written by the faculties without participating in FDPs are usually of low quality. This study suggests that newly joined faculties need active participation in FDPs as these programs are supportive in improving the quality of MCQs' items writing. PMID:25828516

  10. A robust transcriptional program in newts undergoing multiple events of lens regeneration throughout their lifespan

    PubMed Central

    Sousounis, Konstantinos; Qi, Feng; Yadav, Manisha C; Millán, José Luis; Toyama, Fubito; Chiba, Chikafumi; Eguchi, Goro; Tsonis, Panagiotis A

    2015-01-01

    Newts have the ability to repeatedly regenerate their lens even during ageing. However, it is unclear whether this regeneration reflects an undisturbed genetic activity. To answer this question, we compared the transcriptomes of lenses, irises and tails from aged newts that had undergone lens regeneration 19 times with the equivalent tissues from young newts that had never experienced lens regeneration. Our analysis indicates that repeatedly regenerated lenses showed a robust transcriptional program comparable to young never-regenerated lenses. In contrast, the tail, which was never regenerated, showed gene expression signatures of ageing. Our analysis strongly suggests that, with respect to gene expression, the regenerated lenses have not deviated from a robust transcriptional program even after multiple events of regeneration throughout the life of the newt. In addition, our study provides a new paradigm in biology, and establishes the newt as a key model for the study of regeneration in relation to ageing. DOI: http://dx.doi.org/10.7554/eLife.09594.001 PMID:26523389

  11. Faculty development programs improve the quality of Multiple Choice Questions items' writing.

    PubMed

    Abdulghani, Hamza Mohammad; Ahmad, Farah; Irshad, Mohammad; Khalil, Mahmoud Salah; Al-Shaikh, Ghadeer Khalid; Syed, Sadiqa; Aldrees, Abdulmajeed Abdurrahman; Alrowais, Norah; Haque, Shafiul

    2015-01-01

    The aim of this study was to assess the utility of long term faculty development programs (FDPs) in order to improve the quality of multiple choice questions (MCQs) items' writing. This was a quasi-experimental study, conducted with newly joined faculty members. The MCQ items were analyzed for difficulty index, discriminating index, reliability, Bloom's cognitive levels, item writing flaws (IWFs) and MCQs' nonfunctioning distractors (NFDs) based test courses of respiratory, cardiovascular and renal blocks. Significant improvement was found in the difficulty index values of pre- to post-training (p = 0.003). MCQs with moderate difficulty and higher discrimination were found to be more in the post-training tests in all three courses. Easy questions were decreased from 36.7 to 22.5%. Significant improvement was also reported in the discriminating indices from 92.1 to 95.4% after training (p = 0.132). More number of higher cognitive level of Bloom's taxonomy was reported in the post-training test items (p<0.0001). Also, NFDs and IWFs were reported less in the post-training items (p<0.02). The MCQs written by the faculties without participating in FDPs are usually of low quality. This study suggests that newly joined faculties need active participation in FDPs as these programs are supportive in improving the quality of MCQs' items writing. PMID:25828516

  12. Waste management under multiple complexities: inexact piecewise-linearization-based fuzzy flexible programming.

    PubMed

    Sun, Wei; Huang, Guo H; Lv, Ying; Li, Gongchen

    2012-06-01

    To tackle nonlinear economies-of-scale (EOS) effects in interval-parameter constraints for a representative waste management problem, an inexact piecewise-linearization-based fuzzy flexible programming (IPFP) model is developed. In IPFP, interval parameters for waste amounts and transportation/operation costs can be quantified; aspiration levels for net system costs, as well as tolerance intervals for both capacities of waste treatment facilities and waste generation rates can be reflected; and the nonlinear EOS effects transformed from objective function to constraints can be approximated. An interactive algorithm is proposed for solving the IPFP model, which in nature is an interval-parameter mixed-integer quadratically constrained programming model. To demonstrate the IPFP's advantages, two alternative models are developed to compare their performances. One is a conventional linear-regression-based inexact fuzzy programming model (IPFP2) and the other is an IPFP model with all right-hand-sides of fussy constraints being the corresponding interval numbers (IPFP3). The comparison results between IPFP and IPFP2 indicate that the optimized waste amounts would have the similar patterns in both models. However, when dealing with EOS effects in constraints, the IPFP2 may underestimate the net system costs while the IPFP can estimate the costs more accurately. The comparison results between IPFP and IPFP3 indicate that their solutions would be significantly different. The decreased system uncertainties in IPFP's solutions demonstrate its effectiveness for providing more satisfactory interval solutions than IPFP3. Following its first application to waste management, the IPFP can be potentially applied to other environmental problems under multiple complexities. PMID:22370050

  13. Integration of Bilingual Emphasis Program into University Curriculum. Multiple Subjects Credential Program: Hupa, Yurok, Karuk, or Tolowa Emphasis.

    ERIC Educational Resources Information Center

    Bennett, Ruth

    A description of the American Indian Bilingual Teacher Credential Program offered by Humboldt State University (California) provides background information on the linguistic groups served by the program. Accompanying the program descriptions are lists of lower and upper division requirements, descriptions of competency exam, program schedule,…

  14. GED Acquisition Rates From An At-Risk Youth Program's Curriculum as Influenced by Three Criteria: Multiple Intelligence Usage, Class Size, and Its Mentorship Program

    ERIC Educational Resources Information Center

    Fleming, Angela Rene

    2005-01-01

    The purpose of this study was to determine whether a combination of three factors: (1) a reduced student teacher ratio (class size education); (2) a mentorship program and (3) a varied curriculum, via use of the multiple intelligences would successfully improve secondary at risk youths' high school graduation rates. The graduation rate and GED…

  15. Classification of HIV-1-mediated neuronal dendritic and synaptic damage using multiple criteria linear programming.

    PubMed

    Zheng, Jialin; Zhuang, Wei; Yan, Nian; Kou, Gang; Peng, Hui; McNally, Clancy; Erichsen, David; Cheloha, Abby; Herek, Shelley; Shi, Chris

    2004-01-01

    The ability to identify neuronal damage in the dendritic arbor during HIV-1-associated dementia (HAD) is crucial for designing specific therapies for the treatment of HAD. To study this process, we utilized a computer-based image analysis method to quantitatively assess HIV-1 viral protein gp120 and glutamate-mediated individual neuronal damage in cultured cortical neurons. Changes in the number of neurites, arbors, branch nodes, cell body area, and average arbor lengths were determined and a database was formed (http://dm.ist.unomaha. edu/database.htm). We further proposed a two-class model of multiple criteria linear programming (MCLP) to classify such HIV-1-mediated neuronal dendritic and synaptic damages. Given certain classes, including treatments with brain-derived neurotrophic factor (BDNF), glutamate, gp120 or non-treatment controls from our in vitro experimental systems, we used the two-class MCLP model to determine the data patterns between classes in order to gain insight about neuronal dendritic damages. This knowledge can be applied in principle to the design and study of specific therapies for the prevention or reversal of neuronal damage associated with HAD. Finally, the MCLP method was compared with a well-known artificial neural network algorithm to test for the relative potential of different data mining applications in HAD research. PMID:15365193

  16. Using stochastic dual dynamic programming in problems with multiple near-optimal solutions

    NASA Astrophysics Data System (ADS)

    Rougé, Charles; Tilmant, Amaury

    2016-05-01

    Stochastic dual dynamic programming (SDDP) is one of the few algorithmic solutions available to optimize large-scale water resources systems while explicitly considering uncertainty. This paper explores the consequences of, and proposes a solution to, the existence of multiple near-optimal solutions (MNOS) when using SDDP for mid or long-term river basin management. These issues arise when the optimization problem cannot be properly parametrized due to poorly defined and/or unavailable data sets. This work shows that when MNOS exists, (1) SDDP explores more than one solution trajectory in the same run, suggesting different decisions in distinct simulation years even for the same point in the state-space, and (2) SDDP is shown to be very sensitive to even minimal variations of the problem setting, e.g., initial conditions—we call this "algorithmic chaos." Results that exhibit such sensitivity are difficult to interpret. This work proposes a reoptimization method, which simulates system decisions by periodically applying cuts from one given year from the SDDP run. Simulation results obtained through this reoptimization approach are steady state solutions, meaning that their probability distributions are stable from year to year.

  17. A Mixed Integer Linear Program for Solving a Multiple Route Taxi Scheduling Problem

    NASA Technical Reports Server (NTRS)

    Montoya, Justin Vincent; Wood, Zachary Paul; Rathinam, Sivakumar; Malik, Waqar Ahmad

    2010-01-01

    Aircraft movements on taxiways at busy airports often create bottlenecks. This paper introduces a mixed integer linear program to solve a Multiple Route Aircraft Taxi Scheduling Problem. The outputs of the model are in the form of optimal taxi schedules, which include routing decisions for taxiing aircraft. The model extends an existing single route formulation to include routing decisions. An efficient comparison framework compares the multi-route formulation and the single route formulation. The multi-route model is exercised for east side airport surface traffic at Dallas/Fort Worth International Airport to determine if any arrival taxi time savings can be achieved by allowing arrivals to have two taxi routes: a route that crosses an active departure runway and a perimeter route that avoids the crossing. Results indicate that the multi-route formulation yields reduced arrival taxi times over the single route formulation only when a perimeter taxiway is used. In conditions where the departure aircraft are given an optimal and fixed takeoff sequence, accumulative arrival taxi time savings in the multi-route formulation can be as high as 3.6 hours more than the single route formulation. If the departure sequence is not optimal, the multi-route formulation results in less taxi time savings made over the single route formulation, but the average arrival taxi time is significantly decreased.

  18. Programmed two-dimensional self-assembly of multiple DNA origami jigsaw pieces.

    PubMed

    Rajendran, Arivazhagan; Endo, Masayuki; Katsuda, Yousuke; Hidaka, Kumi; Sugiyama, Hiroshi

    2011-01-25

    We demonstrate a novel strategy of self-assembly to scale up origami structures in two-dimensional (2D) space using multiple origami structures, named "2D DNA jigsaw pieces", with a specially designed shape. For execution of 2D self-assembly along the helical axis (horizontal direction), sequence-programmed tenon and mortise were introduced to promote selective connections via π-stacking interaction, sequence-complementarity, and shape-complementarity. For 2D self-assembly along the helical side (vertical direction), the jigsaw shape-complementarity in the top and bottom edges and the sequence-complementarity of single-stranded overhangs were used. We designed and prepared nine different jigsaw pieces and tried to obtain a 3 × 3 assembly. The proof of concept was obtained by performing the assembly in four different ways. Among them, the stepwise self-assembly from the three vertical trimer assemblies gave the target 2D assembly with ∼35% yield. Finally, the surfaces of jigsaw pieces were decorated with hairpin DNAs to display the letters of the alphabet, and the self-assembled 2D structure displayed the word "DNA JIG SAW" in nanoscale. The method can be expanded to create self-assembled modules carrying various functional molecules for practical applications. PMID:21188996

  19. Multiple drug cost containment policies in Michigan's Medicaid program saved money overall, although some increased costs.

    PubMed

    Kibicho, Jennifer; Pinkerton, Steven D

    2012-04-01

    Michigan's Medicaid program implemented four cost containment policies--preferred drug lists, joint and multistate purchasing arrangements, and maximum allowable cost--during 2002-04. The goal was to control growth of drug spending for beneficiaries who were enrolled in both Medicaid and Medicare and taking antihypertensive or antihyperlipidemic prescription drugs. We analyzed the impact of each policy while holding the effect of all other policies constant. Preferred drug lists increased both preferred and generic drugs' market share and reduced daily cost--the cost per day for each prescription provided to a beneficiary. In contrast, the maximum allowable cost policy increased daily cost and was the only policy that did not generate cost savings. The joint and multistate arrangements did not affect daily cost. Despite these policy trade-offs, the cumulative effect was a 10 percent decrease in daily cost and a total cost savings of $46,195 per year. Our findings suggest that policy makers need to evaluate the impact of multiple policies aimed at restraining drug spending, and further evaluate the policy trade-offs, to ensure that scarce public dollars achieve the greatest return for money spent. PMID:22492899

  20. Assisting People with Multiple Disabilities by Improving Their Computer Pointing Efficiency with an Automatic Target Acquisition Program

    ERIC Educational Resources Information Center

    Shih, Ching-Hsiang; Shih, Ching-Tien; Peng, Chin-Ling

    2011-01-01

    This study evaluated whether two people with multiple disabilities would be able to improve their pointing performance through an Automatic Target Acquisition Program (ATAP) and a newly developed mouse driver (i.e. a new mouse driver replaces standard mouse driver, and is able to monitor mouse movement and intercept click action). Initially, both…

  1. Assisting People with Developmental Disabilities Improve Their Collaborative Pointing Efficiency with a Multiple Cursor Automatic Pointing Assistive Program

    ERIC Educational Resources Information Center

    Shih, Ching-Hsiang; Cheng, Hsiao-Fen; Li, Chia-Chun; Shih, Ching-Tien; Chiang, Ming-Shan

    2010-01-01

    This study evaluated whether four persons (two groups) with developmental disabilities would be able to improve their collaborative pointing performance through a Multiple Cursor Automatic Pointing Assistive Program (MCAPAP) with a newly developed mouse driver (i.e., a new mouse driver replaces standard mouse driver, and is able to…

  2. Students with Multiple Disabilities Using Technology-Based Programs to Choose and Access Stimulus Events Alone or with Caregiver Participation

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Oliva, Doretta; Cingolani, Eleonora

    2009-01-01

    The first of these two studies extended preliminary evidence on the use of technology-based programs for enabling students with severe and profound multiple disabilities to choose and access environmental stimuli on their own. Each of the three participants had two microswitches linked to specific sets of stimuli through a computer system. The…

  3. A Technology-Aided Stimulus Choice Program for Two Adults with Multiple Disabilities: Choice Responses and Mood

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Alberti, Gloria; Oliva, Doretta; Buono, Serafino

    2011-01-01

    This study was aimed at replicating and extending early research on technology-aided stimulus choice with two adults with multiple disabilities. The technology-aided program involved (a) a computer-aided system presenting the participants samples of different environmental stimuli and (b) a microswitch device allowing them to choose among those…

  4. Long-Term Effects of the Family Bereavement Program on Multiple Indicators of Grief in Parentally Bereaved Children and Adolescents

    ERIC Educational Resources Information Center

    Sandler, Irwin N.; Ma, Yue; Tein, Jenn-Yun; Ayers, Tim S.; Wolchik, Sharlene; Kennedy, Cara; Millsap, Roger

    2010-01-01

    Objectives: This article reports on results from a randomized experimental trial of the effects of the Family Bereavement Program (FBP) on multiple measures of grief experienced by parentally bereaved children and adolescents over a 6-year period. Method: Participants were 244 youths (ages 8-16, mean age = 11.4 years) from 156 families that had…

  5. Management Development Training; Multiple Measurement of Its Effect When Used to Increase the Impact of a Long Term Motivational Program.

    ERIC Educational Resources Information Center

    Camealy, John Bremer

    This field investigation applied multiple measures to determine effects of management development training when used to increase the benefits from a long term motivational program. Two experimental groups and a control group were used. Instruments applied included the Miner Sentence Completion Scale, the Leadership Opinion Questionnaire (LOQ), and…

  6. Multiple Risk Factor Intervention in the Delivery of Primary Health Care to the Elderly: Lessons from Community-Based Programs.

    ERIC Educational Resources Information Center

    Kligman, Evan W.

    Within the past decade the role of the primary care physician caring for older patients has expanded to include counseling and "healthy aging" education to reduce multiple behavior risk factors. Project AGE WELL was a longitudinal study of the impact of a comprehensive and team delivered health promotion program on the health status of the…

  7. The Effectiveness of the Rocket Math Program for Improving Basic Multiplication Fact Fluency in Fifth Grade Students: A Case Study

    ERIC Educational Resources Information Center

    Rave, Kristen; Golightly, Amy F.

    2014-01-01

    This study examined the impact of a commercially available math fluency intervention program on the basic multiplication fluency of three classrooms of fifth grade students. Baseline assessment and progress monitoring of thirty-three regular- and eleven special education students occurred over nine weeks. Within-group analyses revealed significant…

  8. Safety and Health Benefits of Novel Dietary Supplements Consisting Multiple Phytochemicals, Vitamins, Minerals and Essential Fatty Acids in High Fat Diet Fed Rats.

    PubMed

    Ramprasath, Vanu Ramkumar; Jones, Peter J H

    2016-01-01

    The objective was to determine safety and efficacy of health supplements "Beyond Tangy Tangerine," a multivitamin/mineral complex and combination of multivitamin/mineral complex, "Osteofx," a bone healthy supplement and "Ultimate Essential Fatty Acids" in Sprague Dawley rats consuming high-fat diets. Initially a pilot study was conducted which confirmed palatability and acceptability of supplements. In a second study, rats (n = 15/group) were randomized to Control; Multivitamin/mineral complex (2 g/kg BW) or Combination (2 g Multivitamin/mineral complex, 1.5 g Bone healthy supplement and 0.34 g Essential fatty acids/kg BW). No differences were observed in BW change, feed intake, organ weights or bone mineral composition with supplementations compared to control. Multivitamin/mineral complex supplementation decreased abdominal white adipose tissue weights (WAT) (p = .005), total (p = .033) and fat mass (p = .040), plasma IL-6 (p = .016) and ALKP (p = .038) and elevated plasma calcium (p < .001), phosphorus (p = .038), total protein (p = .002), albumin (p = .014) and globulin (p = .018), compared to control. Similarly, combination supplementation reduced WAT (p < .001), total (p = .023) and fat mass (p = .045), plasma triglycerides (p = .018), IL-6 (p = .002) and ALKP (p < .001) with increases in plasma calcium (p = .031), phosphorus (p < .001) compared to control. Results indicate that consuming either supplement can be considered safe and improves overall health by reducing inflammation, abdominal fat mass and plasma triglycerides, as well as promote bone health. PMID:26317447

  9. Essential Tremor

    MedlinePlus

    ... essential tremor) is the most common form of abnormal tremor. (In some people, tremor is a symptom ... shown this agent to be promising as a potential new treatment. Scientists are also studying the effectiveness ... Tremor Action Network P.O. Box 5013 Pleasanton, CA 94566- ...

  10. Essential Questions

    ERIC Educational Resources Information Center

    Wilhelm, Jeffrey D.

    2012-01-01

    The secret to teaching may be as simple as asking students good questions--and then giving them the opportunity to find the answers. The author shares how he uses essential questions that set the class off on an inquiry. Rather than consuming information that he distributes and then repeating it on a test, students carry out their own…

  11. Learning to Question: The Roles of Multiple Hypotheses, Successive Approximations, Balloons and Toilet Paper in University Science Programs of Southwestern Amazonia

    NASA Astrophysics Data System (ADS)

    Brown, I. Foster

    2008-06-01

    Learning to question is essential for determining pathways of conservation and development in southwestern Amazonia during a time of rapid global environmental change. Teaching such an approach in graduate science programs in regional universities can be done using play-acting and simulation exercises. Multiple working hypotheses help students learn to question their own research results and expert witnesses. The method of successive approximations enables students to question the results of complex calculations, such as estimates of forest biomass. Balloons and rolls of toilet paper provide means of questioning two-dimensional representations of a three-dimensional Earth and the value of pi. Generation of systematic errors can illustrate the pitfalls of blind acceptance of data. While learning to question is essential, it is insufficient by itself; students must also learn how to be solutionologists in order to satisfy societal demands for solutions to environmental problems. A little irreverence can be an excellent didactic tool for helping students develop the skills necessary to lead conservation and development efforts in the region.

  12. A 1966 SUMMER PROGRAM FOR CHILDREN WITH PHYSICAL, MULTIPLE AND MENTAL HANDICAPS, JUNE 22, 1966 - AUGUST 17, 1966. PROGRAM EVALUATION.

    ERIC Educational Resources Information Center

    Milwaukee Public Schools, WI.

    THIS SUMMER PROGRAM FOR HANDICAPPED CHILDREN WAS DESIGNED TO MEET THE SPECIAL NEEDS OF THESE CHILDREN FOR SOCIALIZATION AND BETTER USE OF LEISURE TIME AND TO PROVIDE DATA WHICH WOULD ENABLE THE DIVISION OF MUNICIPAL RECREATION AND ADULT EDUCATION OF THE MILWAUKEE PUBLIC SCHOOLS TO PLAN FUTURE PROGRAMS. BOTH THE MENTALLY HANDICAPPED CHILDREN'S…

  13. Home or away? Choosing a setting for a falls-prevention program for people with multiple sclerosis.

    PubMed

    Gunn, Hilary; Cattaneo, Davide; Finlayson, Marcia; Freeman, Jennifer; Sosnoff, Jacob J

    2014-01-01

    Evidence suggests that choice of setting may be important in influencing the outcomes of rehabilitation programs, as well as optimizing participant satisfaction and adherence. This article aims to examine the factors that may inform the choice of setting for a falls-prevention program tailored to the needs of people with multiple sclerosis, including the influence of setting on program effectiveness, participant engagement, cost, and sustainability. Any new program should ensure that the choice of setting is informed by the intended program outcomes as well as an awareness of the opportunities and challenges presented by each type of setting. Evaluations of falls programs for older people suggest that immediate outcomes are similar regardless of setting; however, long-term outcomes may differ by setting, possibly owing to differential effects on adherence. Programs based away from home may offer benefits in terms of maintaining motivation, providing peer-support opportunities, and allowing regular access to facilitator input, while home-based programs offer unique opportunities for context-based practice and the integration of falls-prevention activities into real life. Additionally, home-based programs may address some of the long-term feasibility issues associated with programs away from home. A "mixed" program incorporating elements of home- and community-based activity may be the most sustainable and effective choice to achieve both long- and short-term goals within a falls-prevention program. However, currently there are significant gaps in knowledge relating to comparative program outcomes, cost, and long-term sustainability. PMID:25694777

  14. Essential debate.

    PubMed

    Zigmond, Jessica

    2012-11-26

    With the election settled, the Obama administration has forged ahead with a draft rule on essential benefits and other provisions under the Affordable Care Act. Key players are still digesting the proposals, but HHS Secretary Kathleen Sebelius, left, says she's confident that the new rules-and an extended deadline related to exchanges-will give states what they need to implement the law. PMID:23326870

  15. Resident selection for a physical medicine and rehabilitation program: feasibility and reliability of the multiple mini-interview.

    PubMed

    Finlayson, Heather C; Townson, Andrea F

    2011-04-01

    The development of a process to select the best residents for training programs is challenging. There is a paucity of literature to support the implementation of an evidence-based approach or even best practice for program directors and selection committees. Although assessment of traditional academic markers such as clerkship grades and licensing examination scores can be helpful, these measures typically fail to capture performance in the noncognitive domains of medicine. In the specialty of physical medicine and rehabilitation, physician competencies such as communication, health advocacy, and managerial and collaborative skills are of particular importance, but these are often difficult to evaluate in admission interviews. Recent research on admission processes for medical schools has demonstrated reliability and validity of the "multiple mini-interview." The objective of our project was to develop and evaluate the multiple mini-interview for a physical medicine and rehabilitation residency training program, with a focus on assessment of the noncognitive physician competencies. We found that the process was feasible, time efficient, and cost-efficient and that there was good interrater reliability. The multiple mini-interview may be applied to other physical medicine and rehabilitation residency programs. Further research is needed to confirm reliability and determine validity. PMID:21765249

  16. Using the Multiple-Matched-Sample and Statistical Controls to Examine the Effects of Magnet School Programs on the Reading and Mathematics Performance of Students

    ERIC Educational Resources Information Center

    Yang, Yu N.; Li, Yuan H.; Tompkins, Leroy J.; Modarresi, Shahpar

    2005-01-01

    This summative evaluation of magnet programs employed a quasi-experimental design to investigate whether or not students enrolled in magnet programs gained any achievement advantage over students who were not enrolled in a magnet program. Researchers used Zero-One Linear Programming to draw multiple sets of matched samples from the non-magnet…

  17. Epistemic Beliefs and Their Relation to Multiple-Text Comprehension: A Norwegian Program of Research

    ERIC Educational Resources Information Center

    Ferguson, Leila E.

    2015-01-01

    Nowadays, students are required to use multiple information sources to complete tasks, both in and out of school. The beliefs that students hold about knowledge and knowing--their epistemic beliefs-- have been linked to successful integration of information across multiple texts. Framed by literature on epistemic belief research from an…

  18. Educational Impact of Graduate Nonprofit Degree Programs: Perspectives of Multiple Stakeholders.

    ERIC Educational Resources Information Center

    Mirabella, Roseanne M.; Wish, Naomi B.

    1999-01-01

    As part of a larger study, focus groups conducted at ten university-based nonprofit-management education programs investigated the impact of the programs on various stakeholders, including faculty, administrators, employers in the nonprofit sector, and alumni. Implications for program goals, targeted skills and competencies, and measurement of…

  19. Essential tremor.

    PubMed Central

    Murray, T. J.

    1981-01-01

    Essential tremor, including the juvenile and senile variations, may be a result of a disorder of the servomechanism that controls physiologic tremor. Hands and arms are affected most commonly, and the tremor can vary in amplitude as well as frequency. Long-term treatment with propranolol has been helpful for some patients, although older patients are less likely to benefit. Other drugs and behaviour modification therapy have been less successful. Surgical treatment is effective but should probably be reserved for severe cases. An effective instrument for measuring the subjective and objective aspects of the tremor is still needed, as is an effective long-term method of treatment. PMID:7018658

  20. Computer program for thermodynamic analysis of open cycle multishaft power system with multiple reheat and intercool

    NASA Technical Reports Server (NTRS)

    Glassman, A. J.

    1974-01-01

    A computer program to analyze power systems having any number of shafts up to a maximum of five is presented. On each shaft there can be as many as five compressors and five turbines, along with any specified number of intervening intercoolers and reheaters. A recuperator can be included. Turbine coolant flow can be accounted for. Any fuel consisting entirely of hydrogen and/or carbon can be used. The program is valid for maximum temperatures up to about 2000 K (3600 R). The system description, the analysis method, a detailed explanation of program input and output including an illustrative example, a dictionary of program variables, and the program listing are explained.

  1. Studies on the factors essential to the initiation and maintenance of multiplication of psittacosis virus (6BC strain) in deficient cells in tissue culture.

    PubMed

    HARE, J D; MORGAN, H R

    1954-05-01

    The growth of psittacosis virus (6BC) was studied in cultures of minced whole chick embryo tissue maintained in either Hanks-Simms solution or Hanks's balanced salt solution (BSS), and in neither medium could sustained, long-term virus growth take place. Addition of beef embryo extract (BEE) to cultures at a time when virus multiplication was declining reversed this general trend and resulted in greater virus growth. This virus-stimulating action of BEE was only partially diminished by colchicine, a mitotic inhibitor, indicating that the action of BEE was not due entirely to the development of a larger population of cells as a result of its enhancement of cell proliferation. Chick embryo tissue cultivated for 13 days in BSS prior to infection lost its ability to support the growth of psittacosis virus, but this capacity could be restored by the addition of BEE, alone or with colchicine, at the time of infection. A significant amount of virus was adsorbed to tissue in BSS alone, indicating that the failure of virus to grow in depleted tissue maintained only in BSS after infection was not due entirely to failure of virus to attach to and invade the cells. It was found that an ultrafiltrate and a dialysate of BEE contained the major part of the stimulating capacity of the whole extract, indicating that the active materials were substances of low molecular weights. Autoclaved lactalbumin hydrolysate was an active stimulator, suggesting that the materials responsible for its activity were relatively heat-stable. Since a chemically defined medium (Parker 199) was equally effective in stimulating viral growth, it should be possible eventually to define the chemical nature of the virus stimulators. The implications of the findings are discussed with special reference to their application in the study of tissue tropisms and of latency in viral infections of cells. PMID:13163322

  2. B Cells Are Essential for Moderating the Inflammatory Response and Controlling Bacterial Multiplication in a Mouse Model of Vaccination against Chlamydophila abortus Infection▿

    PubMed Central

    Buendía, Antonio J.; Ortega, Nieves; Caro, María R.; Del Río, Laura; Gallego, María C.; Sánchez, Joaquín; Navarro, Jose A.; Cuello, Francisco; Salinas, Jesús

    2009-01-01

    The use of inactivated vaccines associated with suitable adjuvants has been demonstrated to confer a good level of protection against Chlamydophila abortus. However, the basis of the immune protective response induced by these vaccines has been poorly studied. B cells act as an immune regulatory population during primary infection by C. abortus. Thus, it was considered of interest to study the role of B cells in an infection after immunization with a killed vaccine. For this, C57BL/6 and B-cell-deficient mice were immunized with a killed vaccine against C. abortus using QS-21 as the adjuvant. After challenge, the course of infection was established by analysis of morbidity, C. abortus burden in the liver, and histopathological changes. The immune response induced was studied by real-time PCR techniques. Experiments involving transfer of immune serum from vaccinated or previously infected mice were also carried out. The lack of B cells reduced the protection conferred by the QS-21 adjuvant vaccine. Vaccinated B-cell-deficient mice showed a 1,000-fold-greater bacterial burden in the liver than their wild-type counterparts. Obvious differences existed in the liver, where a severe neutrophilic reaction and extended areas of necrosis were observed with vaccinated B-cell-deficient mice. An analysis of the immune response pointed to a significant increase in inflammatory cytokines and chemokines and the deficient production of transforming growth factor beta. The transfer of antibodies restored the level of protection. This study demonstrates that B cells play a crucial role in controlling C. abortus multiplication and prevent an exacerbated inflammatory response. PMID:19703981

  3. Essential Role for the Lectin Pathway in Collagen Antibody-Induced Arthritis Revealed Through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression

    PubMed Central

    Banda, Nirmal K.; Mehta, Gaurav; Kjaer, Troels R.; Takahashi, Minoru; Schaack, Jerome; Morrison, Thomas E.; Thiel, Steffen; Arend, William P.; Holers, V. Michael

    2014-01-01

    Previous studies using mannose-binding lectin (MBL) and complement C4 deficient mice have suggested that the lectin pathway (LP) is not required for the development of inflammatory arthritis in the collagen antibody-induced arthritis (CAIA) model. MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases, MASP-1, MASP-2 and MASP-3, and also with two MBL-associated proteins designated sMAP and MAp44. Recent studies have shown that MAp44, an alternatively spliced product of the MASP-1/3 gene, is a competitive inhibitor of the binding of the recognition molecules to all three MASPs. In these studies we examined the effect of treatment of mice with adenovirus (Ad) programmed to express human MAp44 (AdhMAp44) on the development of CAIA. AdhMAp44 and Ad programming Green fluorescent protein (AdGFP) expression were injected intraperitoneally in C57BL/6 wild-type mice prior to the induction of CAIA. AdhMAp44 significantly reduced the clinical disease activity score (CDA) by 81% compared to mice injected with AdGFP. Similarly, histopathologic injury scores for inflammation, pannus, cartilage and bone damage, as well as C3 deposition in the cartilage and synovium, were significantly reduced by AdhMAp44 pretreatment. Mice treated with AdmMAp44, programming expression of mouse MAp44, also showed significantly decreased CDA and histopathologic injury scores. Additionally, administration of AdhMAp44 significantly diminished the severity of Ross River Virus-induced arthritis, a LP-dependent model. Our study provides conclusive evidence that an intact complement LP is essential to initiate CAIA, and that MAp44 may be an appropriate treatment for inflammatory arthritis. PMID:25070856

  4. A computer program for superpositioning multiple UF{sub 6} plume simulations to determine health effects

    SciTech Connect

    Holt, D.D.

    1995-03-01

    The MERGE program is a post-processor for the UF{sub 6} atmospheric dispersion program (ADP). It superimposes the results from several plume simulations and determines for given ground level locations on a grid the total dose and health effect of specified components. The MERGE program utilizes a Gaussian dispersion model`s results, an assumed Gaussian profile, and an approximation for transient behavior.

  5. The First Step to Success Program: An Analysis of Outcomes with Identical Twins across Multiple Baselines.

    ERIC Educational Resources Information Center

    Golly, Annemieke; Sprague, Jeffrey; Walker, Hill; Beard, Kelli; Gorham, Ginger

    2000-01-01

    Two studies evaluated effects of First Step to Success, a collaborative home and school early intervention program designed for kindergartners who show signs of emerging antisocial behavior. Two sets of 5-year-old male twins were the subjects of the 4-year studies. Exposure to the First Step program produced powerful behavior changes that were…

  6. How to Establish the Scientific Value of Multiple GCM-RCM Simulation Programs: An Example from NARCCAP

    NASA Astrophysics Data System (ADS)

    Mearns, L. O.; Dominguez, F.; Gutowski, W. J., Jr.; Hammerling, D.; Lettenmaier, D. P.; Leung, L. Y.; MIchaels, S.; Pryor, S. C.; Sain, S. R.

    2014-12-01

    There have been a number of multiple GCM-RCM programs, covering Europe, North America, and now, through CORDEX, most regions of the world. Standard metrics of success for these programs include number of publications, number of users of the data, and number of citations to the program. However, these metrics do not necessarily reflect the scientific value of the program, for example, what new scientific knowledge has been developed. We began to carefully consider how one does establish the scientific value of such programs. We thought that establishing the scientific value of the North American Regional Climate Change Assessment Program (NARCCAP) would be a good way to examine this issue. We present in this paper our thinking so far on this issue and demonstrate how we are proceeding. We hope that our analysis will prove useful for explicitly establishing the value of such programs throughout the world. Perhaps the most direct indication of a program's value is whether the goals set out for the program have been met. In the case of NARCCAP, this is relatively straightforward. We can point to the research papers published that quantify the uncertainty based on the global and regional climate simulations (e.g., Mearns et al., 2013), and we can point to the number of data users and the number of papers published by the impacts community using the NARCCAP data. Of particular interest, however, is determining what we have learned about future climate projections and their impacts based on the use of higher resolution dynamically generated future climate information. We evaluated all research articles and major reports that used the NARCCAP database, and we report in this talk the major research advances indicated in this literature.

  7. POLYFAIL: a program for identification of multiple fuel failures with gas tagging

    SciTech Connect

    Gross, K. C.

    1980-12-01

    This report describes the development of the computer code POLYFAIL for identification of fuel failures in fast reactors or light-water reactors that use gas tagging. POLYFAIL implements a sophisticated numerical algorithm known as the method of barycentric coordinates. The code can treat problems involving up to four simultaneous tag releases in a tagging system characterized by three independent tag ratios. The sensitivity of the multiple-failure-resolution technique has been optimized by incorporation of a newly developed ratio weighting scheme. Several example problems are provided to demonstrate operation of the code under single-leaker and various postulated multiple-leaker situations.

  8. EFL Learners' Multiple Documents Literacy: Effects of a Strategy-Directed Intervention Program

    ERIC Educational Resources Information Center

    Karimi, Mohammad Nabi

    2015-01-01

    There is a substantial body of L2 research documenting the central role of strategy instruction in reading comprehension. However, this line of research has been conducted mostly within the single text paradigm of reading research. With reading literacy undergoing a marked shift from single source reading to multiple documents literacy, little is…

  9. Multiple Use. Instructor Guide. Working for Clean Water: An Information Program for Advisory Groups.

    ERIC Educational Resources Information Center

    Buskirk, E. Drannon, Jr.

    Examined is the use of wastewater treatment facilities for recreation, education, and open space. Objectives of the learning session described in this instructor's manual are to: (1) introduce opportunities for multiple use, (2) identify areas for citizen input in facility planning and design, and (3) provide criteria for determining local needs…

  10. Beyond Transfer of Training Using Multiple Lenses to Assess Community Education Programs.

    ERIC Educational Resources Information Center

    Ottoson, Judith M.

    1997-01-01

    Assessing effective transfer of training is best done from multiple perspectives: (1) transfer--evidence of skill use in context; (2) enlightenment--what counts as knowledge use; (3) application--evidence of ideas and principles learned; (4) diffusion--spread of innovation over time; and (5) implementation--effects of power, access, and structure…

  11. SOUND SURVEY DESIGNS CAN FACILITATE INTEGRATING STREAM MONITORING DATA ACROSS MULTIPLE PROGRAMS

    EPA Science Inventory

    Multiple agencies in the Pacific Northwest monitor the condition of stream networks or their watersheds. Some agencies use a stream "network" perspective to report on the fraction or length of the network that either meets or violates particular criteria. Other agencies use a "wa...

  12. Development and Feasibility of an Evidence-Based Patient Education Program for Managing Fatigue in Multiple Sclerosis

    PubMed Central

    Feddersen, Lena Katharina; Lau, Stephanie; Köpke, Sascha; Moss-Morris, Rona; Heesen, Christoph; Pöttgen, Jana

    2016-01-01

    Background: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system. Fatigue is a common and disabling symptom, often causing decreased quality of life, social withdrawal, and unemployment. We developed and studied the feasibility of a cognitive-behavioral group intervention to manage fatigue in MS. We aimed to integrate the concepts of cognitive-behavioral therapy and evidence-based patient information. Methods: We conducted patient interviews and a focus group to assess patients' interest in and need for fatigue self-management training and developed the program accordingly. The program consists of six 90-minute modules, which were structured with the use of moderation cards, helping to guarantee treatment fidelity. The program was tested on three pilot groups (N = 16) in a rehabilitation center. Fatigue, depression, and coping self-efficacy were assessed at baseline and after the intervention. Acceptance and general satisfaction with the program were also evaluated. Results: Patient interviews elicited different characteristics of fatigue, suggesting that patients had different requirements. The program was very acceptable to patients. Pre-post assessments of the pilot study showed significantly improved scores on the Coping Self-Efficacy Scale (P = .013) but not on the Fatigue Scale for Motor and Cognitive Functions and the 30-item Inventory of Depressive Symptomatology. Conclusions: These preliminary results suggest that this program is a feasible cognitive-behavioral group training program that may improve coping self-efficacy and has the potential to subsequently reduce fatigue. The next step is evaluation of the program in a randomized controlled trial. PMID:27252600

  13. Instantiating the multiple levels of analysis perspective in a program of study on externalizing behavior

    PubMed Central

    Beauchaine, Theodore P.; Gatzke-Kopp, Lisa M.

    2014-01-01

    During the last quarter century, developmental psychopathology has become increasingly inclusive and now spans disciplines ranging from psychiatric genetics to primary prevention. As a result, developmental psychopathologists have extended traditional diathesis–stress and transactional models to include causal processes at and across all relevant levels of analysis. Such research is embodied in what is known as the multiple levels of analysis perspective. We describe how multiple levels of analysis research has informed our current thinking about antisocial and borderline personality development among trait impulsive and therefore vulnerable individuals. Our approach extends the multiple levels of analysis perspective beyond simple Biology × Environment interactions by evaluating impulsivity across physiological systems (genetic, autonomic, hormonal, neural), psychological constructs (social, affective, motivational), developmental epochs (preschool, middle childhood, adolescence, adulthood), sexes (male, female), and methods of inquiry (self-report, informant report, treatment outcome, cardiovascular, electrophysiological, neuroimaging). By conducting our research using any and all available methods across these levels of analysis, we have arrived at a developmental model of trait impulsivity that we believe confers a greater understanding of this highly heritable trait and captures at least some heterogeneity in key behavioral outcomes, including delinquency and suicide. PMID:22781868

  14. Essential thrombocythemia

    PubMed Central

    Brière, Jean B

    2007-01-01

    Essential thrombocythemia (ET) is an acquired myeloproliferative disorder (MPD) characterized by a sustained elevation of platelet number with a tendency for thrombosis and hemorrhage. The prevalence in the general population is approximately 30/100,000. The median age at diagnosis is 65 to 70 years, but the disease may occur at any age. The female to male ratio is about 2:1. The clinical picture is dominated by a predisposition to vascular occlusive events (involving the cerebrovascular, coronary and peripheral circulation) and hemorrhages. Some patients with ET are asymptomatic, others may experience vasomotor (headaches, visual disturbances, lightheadedness, atypical chest pain, distal paresthesias, erythromelalgia), thrombotic, or hemorrhagic disturbances. Arterial and venous thromboses, as well as platelet-mediated transient occlusions of the microcirculation and bleeding, represent the main risks for ET patients. Thromboses of large arteries represent a major cause of mortality associated with ET or can induce severe neurological, cardiac or peripheral artery manifestations. Acute leukemia or myelodysplasia represent only rare and frequently later-onset events. The molecular pathogenesis of ET, which leads to the overproduction of mature blood cells, is similar to that found in other clonal MPDs such as chronic myeloid leukemia, polycythemia vera and myelofibrosis with myeloid metaplasia of the spleen. Polycythemia vera, myelofibrosis with myeloid metaplasia of the spleen and ET are generally associated under the common denomination of Philadelphia (Ph)-negative MPDs. Despite the recent identification of the JAK2 V617F mutation in a subset of patients with Ph-negative MPDs, the detailed pathogenetic mechanism is still a matter of discussion. Therapeutic interventions in ET are limited to decisions concerning the introduction of anti-aggregation therapy and/or starting platelet cytoreduction. The therapeutic value of hydroxycarbamide and aspirin in high risk

  15. Essential Components of a Perimeter Air Monitoring Plan and Worker Protection Program at Sites Involving the Excavation of Naturally Occurring Asbestos (NOA) in California

    NASA Astrophysics Data System (ADS)

    Zdeb, T. F.

    2012-12-01

    Preparing a Perimeter Air Monitoring Plan that provides the essential information and methods of evaluation needed to assure that the health of the surrounding community is adequately protected and adapting currently existing Cal/OSHA regulations to be relevant to the protection of workers at sites involving the excavation of Naturally Occurring Asbestos (NOA) is oftentimes challenging in California. Current guidelines regarding what constitutes an effective air monitoring program are often lacking in details regarding what should be sampled and analyzed to characterize a site and what evaluation techniques should be applied to process the results of monitoring, and the current Cal/OSHA asbestos related regulations regarding worker protection are for the most part largely pertinent to the abatement of asbestos in buildings. An overview of the essential components of an effective Baseline and Perimeter Air Monitoring Plan will be presented that includes a brief discussion of the various asbestos types and fiber sizes that may need to be considered, possible approachs for evaluating temporal and spatial variability, review of selected site boundary target concentrations, and consideration of the potential for airborne dust and soil containing asbestos (and other contaminants) to migrate and accumulate offsite eventually contributing to "background creep" --the incremental increase of overall airborne asbestos concentrations in the areas surrounding the site due to the re-entrainment of asbestos from the settled dust and/or transported soil. In addition to the above, the current Cal/OSHA asbestos regulations related to worker protection will be briefly discussed with respect to their relevancy at NOA sites with an overview of the adaptations to the regulations that were developed as a result of some fairly lengthy discussions with representatives of Cal/OSHA. These adaptations include, among other things, defining how regulated areas (asbestos concentrations over 1

  16. Predicting Student Grades in Learning Management Systems with Multiple Instance Genetic Programming

    ERIC Educational Resources Information Center

    Zafra, Amelia; Ventura, Sebastian

    2009-01-01

    The ability to predict a student's performance could be useful in a great number of different ways associated with university-level learning. In this paper, a grammar guided genetic programming algorithm, G3P-MI, has been applied to predict if the student will fail or pass a certain course and identifies activities to promote learning in a…

  17. Monitoring multiple species: Estimating state variables and exploring the efficacy of a monitoring program

    USGS Publications Warehouse

    Mattfeldt, S.D.; Bailey, L.L.; Grant, E.H.C.

    2009-01-01

    Monitoring programs have the potential to identify population declines and differentiate among the possible cause(s) of these declines. Recent criticisms regarding the design of monitoring programs have highlighted a failure to clearly state objectives and to address detectability and spatial sampling issues. Here, we incorporate these criticisms to design an efficient monitoring program whose goals are to determine environmental factors which influence the current distribution and measure change in distributions over time for a suite of amphibians. In designing the study we (1) specified a priori factors that may relate to occupancy, extinction, and colonization probabilities and (2) used the data collected (incorporating detectability) to address our scientific questions and adjust our sampling protocols. Our results highlight the role of wetland hydroperiod and other local covariates in the probability of amphibian occupancy. There was a change in overall occupancy probabilities for most species over the first three years of monitoring. Most colonization and extinction estimates were constant over time (years) and space (among wetlands), with one notable exception: local extinction probabilities for Rana clamitans were lower for wetlands with longer hydroperiods. We used information from the target system to generate scenarios of population change and gauge the ability of the current sampling to meet monitoring goals. Our results highlight the limitations of the current sampling design, emphasizing the need for long-term efforts, with periodic re-evaluation of the program in a framework that can inform management decisions.

  18. Designing monitoring programs in an adaptive management context for regional multiple species conservation plans

    USGS Publications Warehouse

    Atkinson, A.J.; Trenham, P.C.; Fisher, R.N.; Hathaway, S.A.; Johnson, B.S.; Torres, S.G.; Moore, Y.C.

    2004-01-01

    critical management uncertainties; and 3) implementing long-term monitoring and adaptive management. Ultimately, the success of regional conservation planning depends on the ability of monitoring programs to confront the challenges of adaptively managing and monitoring complex ecosystems and diverse arrays of sensitive species.

  19. A Multiple Case Study of Successful Inclusion Programs within the Broward County School District

    ERIC Educational Resources Information Center

    Montgomery, Corey Allen

    2012-01-01

    The interpretive nature of this dissertation study was grounded in the field of qualitative research. The purpose of the study was to qualitatively define successful inclusion instruction and/or programming. The units of analysis were three schools at each academic level within the Broward County School District which made Adequate Yearly Progress…

  20. Omaha Public Schools Multiple Activities Program: An Evaluation. ESEA Title I 1975-76.

    ERIC Educational Resources Information Center

    DeBoer, John; Dvorak, Ronald S.

    Emphasis in the 1975-76 Omaha Elementary Secondary Education Act Title I program for disadvantaged youth was on reading activities. The High Intensity Learning Centers for Reading for grades three through twelve continued their operations. Development of Primary High Intensity Centers in reading was continued to provide a supportive reading skill…

  1. Outcomes of a Peer Support Program in Multiple Sclerosis in an Australian Community Cohort: A Prospective Study

    PubMed Central

    2013-01-01

    Background/Objectives. This pilot study evaluated the impact of a peer support program on improving multiple sclerosis (MS) related psychological functions (depression, anxiety, and stress) and enhancing quality of life. Methodology. Participants (n = 33) were recruited prospectively and received an 8-week group face-to-face peer support program. Assessments were at baseline (T1), 6 weeks after program (T2), and 12 months after program (T3), using validated questionnaires: Depression Anxiety Stress Scale (DASS), McGill Quality of Life (MQOL), and Brief COPE. Results. Participants' mean age was 52; the majority were female (64%) and married (64%). Median time since MS diagnosis was 16 years. At T2, participants reported improved psychological functioning (DASS “depression,” “anxiety,” and “stress” subscales, z values −2.36, −2.22, and −2.54, moderate effect sizes (r) 0.29, 0.28, and 0.32, resp.) and quality of life (MQOL SIS z score −2.07, r = 0.26) and were less likely to use “self-blame” as a coping mechanism (Brief COPE z score −2.37, r = 0.29). At T3, the positive improvements in stress (DASS stress subscale z score −2.41, r = 0.31) and quality of life were maintained (MQOL SIS, z score −2.30, r = 0.29). There were no adverse effects reported. PMID:26316989

  2. Germ Line Transcripts Are Processed by a Dicer-Like Protein That Is Essential for Developmentally Programmed Genome Rearrangements of Tetrahymena thermophila

    PubMed Central

    Malone, Colin D.; Anderson, Alissa M.; Motl, Jason A.; Rexer, Charles H.; Chalker, Douglas L.

    2005-01-01

    Abundant ∼28-nucleotide RNAs that are thought to direct histone H3 lysine 9 (H3K9) methylation and promote the elimination of nearly 15 Mbp of DNA from the developing somatic genome are generated during Tetrahymena thermophila conjugation. To identify the protein(s) that generates these small RNAs, we studied three Dicer-related genes encoded within the Tetrahymena genome, two that contain both RNase III and RNA helicase motifs, Dicer 1 (DCR1) and DCR2, and a third that lacks the helicase domain, Dicer-like 1 (DCL1). DCL1 is expressed upon the initiation of conjugation, and the protein localizes to meiotic micronuclei when bidirectional germ line transcription occurs and small RNAs begin to accumulate. Cells in which we disrupted the DCL1 gene (ΔDCL1) grew normally and initiated conjugation as wild-type cells but arrested near the end of development and eventually died, unable to resume vegetative growth. These ΔDCL1 cells failed to generate the abundant small RNAs but instead accumulated germ line-limited transcripts. Together, our findings demonstrate that these transcripts are the precursors of the small RNAs and that DCL1 performs RNA processing within the micronucleus. Postconjugation ΔDCL1 cells die without eliminating the germ line-limited DNA sequences from their newly formed somatic macronuclei, a result that shows that this Dicer-related gene is required for programmed DNA rearrangements. Surprisingly, ΔDCL1 cells were not deficient in overall H3K9 methylation, but this modification was not enriched on germ line-limited sequences as it is in wild-type cells, which clearly demonstrates that these small RNAs are essential for its targeting to specific loci. PMID:16199890

  3. Effects of an Oral-Sensory/Oral-Motor Stimulation/Positive Reinforcement Program on the Acceptance of Nonpreferred Foods by Youth with Physical and Multiple Disabilities

    ERIC Educational Resources Information Center

    Bailey, Rita L.; Angell, Maureen E.

    2005-01-01

    This study employed a multiple probe design to evaluate the effectiveness of a school-based lunchtime oral-sensory/oral-motor/positive reinforcement program on food acceptance behaviors of three youth with multiple disabilities. Overall dramatic gains in food acceptance behaviors of all participants indicated that trained school personnel were…

  4. People with multiple disabilities learn to engage in occupation and work activities with the support of technology-aided programs.

    PubMed

    Lancioni, Giulio E; Singh, Nirbhay N; O'Reilly, Mark F; Sigafoos, Jeff; Alberti, Gloria; Perilli, Viviana; Laporta, Dominga; Campodonico, Francesca; Oliva, Doretta; Groeneweg, Jop

    2014-06-01

    These two studies were aimed at assessing technology-aided programs to help persons with multiple disabilities engage in basic occupation or work activities. Specifically, Study I focused on teaching two participants (an adolescent and an adult) with low vision or total blindness, severe/profound intellectual disabilities, and minimal object interaction to engage in constructive object-manipulation responses. The technology monitored their responses and followed them with brief stimulation periods automatically. Study II focused on teaching three adults with deafness, severe visual impairment, and profound intellectual disabilities to perform a complex activity, that is, to assemble a five-component water pipe. The technology regulated (a) light cues to guide the participants through the workstations containing single pipe components and the carton for completed pipes and (b) stimulation events. The results of both studies were positive. The participants of Study I showed consistent and independent engagement in object-manipulation responses. The participants of Study II showed consistent and independent pipe assembling performance. General implications of the two programs and the related technology packages for intervention with persons with multiple disabilities are discussed. PMID:24685943

  5. TRW vortex-lattice method subsonic aerodynamic analysis for multiple-lifting-surfaces (N. surface) TRW program number HA010B

    NASA Technical Reports Server (NTRS)

    Gomez, A. V.

    1972-01-01

    The program was designed to provide solutions of engineering accuracy for determining the aerodynamic loads on single- or multiple-lifting-surface configurations that represent vehicles in subsonic flight, e.g., wings, wing-tail, wing-canard, lifting bodies, etc. The preparation is described of the input data, associated input arrangement, and the output format for the program data, including specification of the various operational details of the program such as array sizes, tape numbers utilized, and program dumps. A full description of the underlying theory used in the program development and a review of the program qualification tests are included.

  6. Interval-parameter semi-infinite fuzzy-stochastic mixed-integer programming approach for environmental management under multiple uncertainties

    SciTech Connect

    Guo, P.; Huang, G.H.

    2010-03-15

    In this study, an interval-parameter semi-infinite fuzzy-chance-constrained mixed-integer linear programming (ISIFCIP) approach is developed for supporting long-term planning of waste-management systems under multiple uncertainties in the City of Regina, Canada. The method improves upon the existing interval-parameter semi-infinite programming (ISIP) and fuzzy-chance-constrained programming (FCCP) by incorporating uncertainties expressed as dual uncertainties of functional intervals and multiple uncertainties of distributions with fuzzy-interval admissible probability of violating constraint within a general optimization framework. The binary-variable solutions represent the decisions of waste-management-facility expansion, and the continuous ones are related to decisions of waste-flow allocation. The interval solutions can help decision-makers to obtain multiple decision alternatives, as well as provide bases for further analyses of tradeoffs between waste-management cost and system-failure risk. In the application to the City of Regina, Canada, two scenarios are considered. In Scenario 1, the City's waste-management practices would be based on the existing policy over the next 25 years. The total diversion rate for the residential waste would be approximately 14%. Scenario 2 is associated with a policy for waste minimization and diversion, where 35% diversion of residential waste should be achieved within 15 years, and 50% diversion over 25 years. In this scenario, not only landfill would be expanded, but also CF and MRF would be expanded. Through the scenario analyses, useful decision support for the City's solid-waste managers and decision-makers has been generated. Three special characteristics of the proposed method make it unique compared with other optimization techniques that deal with uncertainties. Firstly, it is useful for tackling multiple uncertainties expressed as intervals, functional intervals, probability distributions, fuzzy sets, and their

  7. Accessorizing Building Science – A Web Platform to Support Multiple Market Transformation Programs

    SciTech Connect

    Madison, Michael C.; Antonopoulos, Chrissi A.; Dowson, Scott T.; Franklin, Trisha L.; Carlsen, Leif C.; Baechler, Michael C.

    2014-09-28

    As demand for improved energy efficiency in homes increases, builders need information on the latest findings in building science, rapidly ramping-up energy codes, and technical requirements for labeling programs. The Building America Solution Center is a Department of Energy (DOE) website containing hundreds of expert guides designed to help residential builders install efficiency measures in new and existing homes. Builders can package measures with other media for customized content. Website content provides technical support to market transformation programs such as ENERGY STAR and has been cloned and adapted to provide content for the Better Buildings Residential Program. The Solution Center uses the Drupal open source content management platform to combine a variety of media in an interactive manner to make information easily accessible. Developers designed a unique taxonomy to organize and manage content. That taxonomy was translated into web-based modules that allow users to rapidly traverse structured content with related topics, and media. We will present information on the current design of the Solution Center and the underlying technology used to manage the content. The paper will explore development of features, such as “Field Kits” that allow users to bundle and save content for quick access, along with the ability to export PDF versions of content. Finally, we will discuss development of an Android based mobile application, and a visualization tool for interacting with Building Science Publications that allows the user to dynamically search the entire Building America Library.

  8. Professors & Practitioners Collaborating on Building a Model of Essential Teaching and Classroom Management Skills within a Major Reform Program: Reliability & Validity Profiling Teacher Characteristics as Related to Student Achievement.

    ERIC Educational Resources Information Center

    Packard, Richard D.; And Others

    The cooperative efforts of researchers and practitioners in building a model of essential teaching and classroom management skills as part of a process of educational reform are illustrated in this study by a local school administrator and university program directors and professors. The reform effort was part of the Arizona Career Ladder pilot…

  9. Action of Multiple Endoplasmic Reticulum Chaperon-like Proteins Is Required for Proper Folding and Polarized Localization of Kre6 Protein Essential in Yeast Cell Wall β-1,6-Glucan Synthesis*

    PubMed Central

    Kurita, Tomokazu; Noda, Yoichi; Yoda, Koji

    2012-01-01

    Saccharomyces cerevisiae Kre6 is a type II membrane protein essential for cell wall β-1,6-glucan synthesis. Recently we reported that the majority of Kre6 is in the endoplasmic reticulum (ER), but a significant portion of Kre6 is found in the plasma membrane of buds, and this polarized appearance of Kre6 is required for β-1,6-glucan synthesis. An essential membrane protein, Keg1, and ER chaperon Rot1 bind to Kre6. In this study we found that in mutant keg1-1 cells, accumulation of Kre6 at the buds is diminished, binding of Kre6 to Keg1 is decreased, and Kre6 becomes susceptible to ER-associated degradation (ERAD), which suggests Keg1 participates in folding and transport of Kre6. All mutants of the calnexin cycle member homologues (cwh41, rot2, kre5, and cne1) showed defects in β-1,6-glucan synthesis, although the calnexin chaperon system is considered not functional in yeast. We found synthetic defects between them and keg1-1, and Cne1 co-immunoprecipitated with Keg1 and Kre6. A stronger binding of Cne1 to Kre6 was detected when two glucosidases (Cwh41 and Rot2) that remove glucose on N-glycan were functional. Skn1, a Kre6 homologue, was not detected by immunofluorescence in the wild type yeast, but in kre6Δ cells it became detectable and behaved like Kre6. In conclusion, the action of multiple ER chaperon-like proteins is required for proper folding and localization of Kre6 and probably Skn1 to function in β-1,6-glucan synthesis. PMID:22447934

  10. A Microswitch-Cluster Program to Foster Adaptive Responses and Head Control in Students with Multiple Disabilities: Replication and Validation Assessment

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Oliva, Doretta; Gatti, Michela; Manfredi, Francesco; Megna, Gianfranco; La Martire, Maria L.; Tota, Alessia; Smaldone, Angela; Groeneweg, Jop

    2008-01-01

    A program relying on microswitch clusters (i.e., combinations of microswitches) and preferred stimuli was recently developed to foster adaptive responses and head control in persons with multiple disabilities. In the last version of this program, preferred stimuli (a) are scheduled for adaptive responses occurring in combination with head control…

  11. Increasing Adaptive Responses and Reducing Finger Mouthing in an Adolescent with Multiple Disabilities: Evaluation of an Upgraded Microswitch-Cluster Program

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; O'Reilly, Mark F.; Singh, Nirbhay N.; Sigafoos, Jeff; Oliva, Doretta; Cingolani, Eleonora; D'Oro, Lega F.

    2008-01-01

    We evaluated an upgraded version of a microswitch-cluster program used for promoting adaptive foot and head responses and reducing finger mouthing with a boy with multiple disabilities. The boy had been exposed to an early version of the program, which ensured that positive stimulation followed only adaptive responses occurring free from finger…

  12. Technical Note: Calculation of standard errors of estimates of genetic parameters with the multiple-trait derivative-free restricted maximal likelihood programs

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The MTDFREML (Boldman et al., 1995) set of programs was written to handle partially missing data in an expedient manner. When estimating (co)variance components and genetic parameters for multiple trait models, the programs have not been able to estimate standard errors of those estimates for multi...

  13. "Helpful People in Touch" Consumer Led Self Help Programs for People with Multiple Disorders, Mental Illness, Drug Addiction, and Alcoholism (MIDAA).

    ERIC Educational Resources Information Center

    Sciacca, Kathleen

    This paper describes the consumer program, "Helpful People in Touch," a self-help treatment program for people with the multiple disorders of mental illness, drug addiction, and/or alcoholism. First, the terms, "Mentally Ill Chemical Abusers and Addicted" (MICAA) and "Chemical Abusing Mentally Ill" (CAMI) are defined and differentiated, with…

  14. Report for simultaneous, multiple independently steered beam study for Airborne Electronically Steerable Phased Array (AESPA) program

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Design concepts of an array for the formation of multiple, simultaneous, independently pointed beams for satellite communication links were investigated through tradeoffs of various approaches which were conceived as possible solutions to the problem. After the preferred approach was selected, a more detailed design was configured and is presented as a candidate system that should be given further consideration for development leading to a preliminary design. This array uses an attenuator and a phase shifter with every element. The aperture excitation necessary to form the four beams is calculated and then placed across the array using these devices. Pattern analysis was performed for two beam and four beam cases with numerous patterns being presented. Parameter evaluation shown includes pointing accuracy and beam shape, sidelobe characteristics, gain control, and beam normalization. It was demonstrated that a 4 bit phase shifter and a 6 bit, 30 dB attenuator were sufficient to achieve adequate pattern performances. The phase amplitude steered multibeam array offers the flexibility of 1 to 4 beams with an increase in gain of 6 dB if only one beam is selected.

  15. Multiple sample characterization of coals and other substances by controlled-atmosphere programmed temperature oxidation

    DOEpatents

    LaCount, Robert B.

    1993-01-01

    A furnace with two hot zones holds multiple analysis tubes. Each tube has a separable sample-packing section positioned in the first hot zone and a catalyst-packing section positioned in the second hot zone. A mass flow controller is connected to an inlet of each sample tube, and gas is supplied to the mass flow controller. Oxygen is supplied through a mass flow controller to each tube to either or both of an inlet of the first tube and an intermediate portion between the tube sections to intermingle with and oxidize the entrained gases evolved from the sample. Oxidation of those gases is completed in the catalyst in each second tube section. A thermocouple within a sample reduces furnace temperature when an exothermic condition is sensed within the sample. Oxidized gases flow from outlets of the tubes to individual gas cells. The cells are sequentially aligned with an infrared detector, which senses the composition and quantities of the gas components. Each elongated cell is tapered inward toward the center from cell windows at the ends. Volume is reduced from a conventional cell, while permitting maximum interaction of gas with the light beam. Reduced volume and angulation of the cell inlets provide rapid purgings of the cell, providing shorter cycles between detections. For coal and other high molecular weight samples, from 50% to 100% oxygen is introduced to the tubes.

  16. A generalized method for multiple robotic manipulator programming applied to vertical-up welding

    NASA Technical Reports Server (NTRS)

    Fernandez, Kenneth R.; Cook, George E.; Andersen, Kristinn; Barnett, Robert Joel; Zein-Sabattou, Saleh

    1991-01-01

    The application is described of a weld programming algorithm for vertical-up welding, which is frequently desired for variable polarity plasma arc welding (VPPAW). The Basic algorithm performs three tasks simultaneously: control of the robotic mechanism so that proper torch motion is achieved while minimizing the sum-of-squares of joint displacement; control of the torch while the part is maintained in a desirable orientation; and control of the wire feed mechanism location with respect to the moving welding torch. Also presented is a modification of this algorithm which permits it to be used for vertical-up welding. The details of this modification are discussed and simulation examples are provided for illustration and verification.

  17. p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps

    PubMed Central

    Wu, Zhenguo; Woodring, Pamela J.; Bhakta, Kunjan S.; Tamura, Kumiko; Wen, Fang; Feramisco, James R.; Karin, Michael; Wang, Jean Y. J.; Puri, Pier Lorenzo

    2000-01-01

    The extracellular signals which regulate the myogenic program are transduced to the nucleus by mitogen-activated protein kinases (MAPKs). We have investigated the role of two MAPKs, p38 and extracellular signal-regulated kinase (ERK), whose activities undergo significant changes during muscle differentiation. p38 is rapidly activated in myocytes induced to differentiate. This activation differs from those triggered by stress and cytokines, because it is not linked to Jun–N-terminal kinase stimulation and is maintained during the whole process of myotube formation. Moreover, p38 activation is independent of a parallel promyogenic pathway stimulated by insulin-like growth factor 1. Inhibition of p38 prevents the differentiation program in myogenic cell lines and human primary myocytes. Conversely, deliberate activation of endogenous p38 stimulates muscle differentiation even in the presence of antimyogenic cues. Much evidence indicates that p38 is an activator of MyoD: (i) p38 kinase activity is required for the expression of MyoD-responsive genes, (ii) enforced induction of p38 stimulates the transcriptional activity of a Gal4-MyoD fusion protein and allows efficient activation of chromatin-integrated reporters by MyoD, and (iii) MyoD-dependent myogenic conversion is reduced in mouse embryonic fibroblasts derived from p38α−/− embryos. Activation of p38 also enhances the transcriptional activities of myocyte enhancer binding factor 2A (MEF2A) and MEF2C by direct phosphorylation. With MEF2C, selective phosphorylation of one residue (Thr293) is a tissue-specific activating signal in differentiating myocytes. Finally, ERK shows a biphasic activation profile, with peaks of activity in undifferentiated myoblasts and postmitotic myotubes. Importantly, activation of ERK is inhibitory toward myogenic transcription in myoblasts but contributes to the activation of myogenic transcription and regulates postmitotic responses (i.e., hypertrophic growth) in myotubes. PMID

  18. Multiple-Language Program Assessment: Learners' Perspectives on First- and Second-Year College Foreign Language Programs and Their Implications for Program Improvement

    ERIC Educational Resources Information Center

    Rivera, Gladys M.; Matsuzawa, Chie

    2007-01-01

    A pilot study was designed to examine student perspectives on the first two years of the foreign language program at an east coast college. The study addresses key areas of foreign language teaching and learning in terms of goals and objectives, effectiveness of instruction and instructional approach, and student suggestions for improvement. The…

  19. Autographa californica multiple nucleopolyhedrovirus ODV-E56 is a per os infectivity factor, but is not essential for binding and fusion of occlusion-derived virus to the host midgut

    SciTech Connect

    Sparks, Wendy O.; Harrison, Robert L.; Bonning, Bryony C.

    2011-01-05

    The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) occlusion-derived virus (ODV) envelope protein ODV-E56 is essential for oral infection of larvae of Heliothis virescens. Bioassays with recombinant clones of AcMNPV lacking a functional odv-e56 gene showed that ODV-E56 was required for infectivity of both polyhedra and to a lesser extent, purified ODV. However, binding and fusion assays showed that ODV lacking ODV-E56 bound and fused to midgut cells at levels similar to ODV of wild-type virus. Fluorescence microscopy of midguts from larvae inoculated with ODV-E56-positive and -negative viruses that express GFP indicated that ODV-E56 was required for infection of the midgut epithelium. Purified ODV-E56 bound to several proteins in midgut-derived brush border membrane vesicles, but failed to rescue infectivity of ODV-E56-negative viruses in trans. These results indicate that ODV-E56 is a per os infectivity factor (pif-5) required for primary midgut infection at a point before or after virion binding and fusion.

  20. A pilot study of an exercise-based patient education program in people with multiple sclerosis.

    PubMed

    Kersten, Stephanie; Mahli, Mohammed; Drosselmeyer, Julia; Lutz, Christina; Liebherr, Magnus; Schubert, Patric; Haas, Christian T

    2014-01-01

    There is increasing evidence that physical exercise leads to numerous positive effects in PwMS. However, long-term effects of exercise may only be achievable if training is implemented in daily routine. Enabling patients to exercise regularly, we developed a patient education program focused on evidence-based information of training. PwMS were educated in neurophysiological effects of physical exercise, exercise-induced benefits for PwMS, and risk factors (e.g., weather). Fifteen PwMS were analyzed before (T 0) and after (T 1) a 12-week patient education. Afterwards, participants performed their exercises autonomously for 32 weeks and were tested in sustainability tests (T 2). Guided interviews were carried out, additionally. Significant improvements from T 0 to T 1 were found in 6MWT, gait velocity, TUG, fatigue, and quality of life. Significant results of TUG and gait velocity from T 1 to T 2 demonstrated that participants kept few effects after the 32-week training phase. Qualitative analyses showed improved self-confidence and identified training strategies and barriers. This pilot study provides evidence that PwMS are able to acquire good knowledge about physical exercise and apply this knowledge successfully in training management. One might conclude that this exercise-based patient education seems to be a feasible option to maintain or improve patients' integral constitution concerning physical and mental health. PMID:25587449

  1. A Pilot Study of an Exercise-Based Patient Education Program in People with Multiple Sclerosis

    PubMed Central

    Mahli, Mohammed; Drosselmeyer, Julia; Lutz, Christina; Liebherr, Magnus; Schubert, Patric; Haas, Christian T.

    2014-01-01

    There is increasing evidence that physical exercise leads to numerous positive effects in PwMS. However, long-term effects of exercise may only be achievable if training is implemented in daily routine. Enabling patients to exercise regularly, we developed a patient education program focused on evidence-based information of training. PwMS were educated in neurophysiological effects of physical exercise, exercise-induced benefits for PwMS, and risk factors (e.g., weather). Fifteen PwMS were analyzed before (T0) and after (T1) a 12-week patient education. Afterwards, participants performed their exercises autonomously for 32 weeks and were tested in sustainability tests (T2). Guided interviews were carried out, additionally. Significant improvements from T0 to T1 were found in 6MWT, gait velocity, TUG, fatigue, and quality of life. Significant results of TUG and gait velocity from T1 to T2 demonstrated that participants kept few effects after the 32-week training phase. Qualitative analyses showed improved self-confidence and identified training strategies and barriers. This pilot study provides evidence that PwMS are able to acquire good knowledge about physical exercise and apply this knowledge successfully in training management. One might conclude that this exercise-based patient education seems to be a feasible option to maintain or improve patients' integral constitution concerning physical and mental health. PMID:25587449

  2. Fuzzy bilevel programming with multiple non-cooperative followers: model, algorithm and application

    NASA Astrophysics Data System (ADS)

    Ke, Hua; Huang, Hu; Ralescu, Dan A.; Wang, Lei

    2016-04-01

    In centralized decision problems, it is not complicated for decision-makers to make modelling technique selections under uncertainty. When a decentralized decision problem is considered, however, choosing appropriate models is no longer easy due to the difficulty in estimating the other decision-makers' inconclusive decision criteria. These decision criteria may vary with different decision-makers because of their special risk tolerances and management requirements. Considering the general differences among the decision-makers in decentralized systems, we propose a general framework of fuzzy bilevel programming including hybrid models (integrated with different modelling methods in different levels). Specially, we discuss two of these models which may have wide applications in many fields. Furthermore, we apply the proposed two models to formulate a pricing decision problem in a decentralized supply chain with fuzzy coefficients. In order to solve these models, a hybrid intelligent algorithm integrating fuzzy simulation, neural network and particle swarm optimization based on penalty function approach is designed. Some suggestions on the applications of these models are also presented.

  3. Multiple Cis-acting elements modulate programmed -1 ribosomal frameshifting in Pea enation mosaic virus.

    PubMed

    Gao, Feng; Simon, Anne E

    2016-01-29

    Programmed -1 ribosomal frameshifting (-1 PRF) is used by many positive-strand RNA viruses for translation of required products. Despite extensive studies, it remains unresolved how cis-elements just downstream of the recoding site promote a precise level of frameshifting. The Umbravirus Pea enation mosaic virus RNA2 expresses its RNA polymerase by -1 PRF of the 5'-proximal ORF (p33). Three hairpins located in the vicinity of the recoding site are phylogenetically conserved among Umbraviruses. The central Recoding Stimulatory Element (RSE), located downstream of the p33 termination codon, is a large hairpin with two asymmetric internal loops. Mutational analyses revealed that sequences throughout the RSE and the RSE lower stem (LS) structure are important for frameshifting. SHAPE probing of mutants indicated the presence of higher order structure, and sequences in the LS may also adapt an alternative conformation. Long-distance pairing between the RSE and a 3' terminal hairpin was less critical when the LS structure was stabilized. A basal level of frameshifting occurring in the absence of the RSE increases to 72% of wild-type when a hairpin upstream of the slippery site is also deleted. These results suggest that suppression of frameshifting may be needed in the absence of an active RSE conformation. PMID:26578603

  4. Multiple Cis-acting elements modulate programmed -1 ribosomal frameshifting in Pea enation mosaic virus

    PubMed Central

    Gao, Feng; Simon, Anne E.

    2016-01-01

    Programmed -1 ribosomal frameshifting (-1 PRF) is used by many positive-strand RNA viruses for translation of required products. Despite extensive studies, it remains unresolved how cis-elements just downstream of the recoding site promote a precise level of frameshifting. The Umbravirus Pea enation mosaic virus RNA2 expresses its RNA polymerase by -1 PRF of the 5′-proximal ORF (p33). Three hairpins located in the vicinity of the recoding site are phylogenetically conserved among Umbraviruses. The central Recoding Stimulatory Element (RSE), located downstream of the p33 termination codon, is a large hairpin with two asymmetric internal loops. Mutational analyses revealed that sequences throughout the RSE and the RSE lower stem (LS) structure are important for frameshifting. SHAPE probing of mutants indicated the presence of higher order structure, and sequences in the LS may also adapt an alternative conformation. Long-distance pairing between the RSE and a 3′ terminal hairpin was less critical when the LS structure was stabilized. A basal level of frameshifting occurring in the absence of the RSE increases to 72% of wild-type when a hairpin upstream of the slippery site is also deleted. These results suggest that suppression of frameshifting may be needed in the absence of an active RSE conformation. PMID:26578603

  5. Three non-ambulatory adults with multiple disabilities exercise foot-leg movements through microswitch-aided programs.

    PubMed

    Lancioni, Giulio E; Singh, Nirbhay N; O'Reilly, Mark F; Sigafoos, Jeff; Alberti, Gloria; Oliva, Doretta; Campodonico, Francesca

    2013-09-01

    This study assessed the use of microswitch-aided programs to help three non-ambulatory adults with multiple disabilities exercise foot-leg responses. Those responses served to activate a largely neglected part of the participants' body, with possibly positive physical implications (e.g., for blood circulation, swelling, and muscle strength). Intervention focused on the left and right foot-leg response, separately. Eventually, sessions with one response were alternated with sessions with the other response. Responses were monitored via microswitches and followed by 8s of preferred stimulation (e.g., music and vibrotactile stimulation), which was automatically delivered. The results showed that all three participants had high levels of foot-leg responses during the intervention phases and a 3-week post-intervention check. The participants also displayed expressions of positive involvement during those study periods (i.e., engaged in behaviors, such as music-related head movements, smiles, or touching the vibratory devices) that could be interpreted as forms of interest/pleasure and happiness. These results are in line with previous findings in this area and can be taken as an important confirmation of the strength and dependability of the approach in motivating non-ambulatory persons with multiple disabilities to engage in foot-leg movements. The practical implications of these findings are discussed. PMID:23796459

  6. A Study in Predicting English Grades for First-Time-in-College Students Using the Career Planning Program (CPP) and Multiple Assessment and Program Services (MAPS) Reading and Language Scores, Age, Gender, and Race.

    ERIC Educational Resources Information Center

    Johnson, Randell G.

    To identify a set of predictor variables for student grades in a first-quarter English course, a study was undertaken of students' reading and language scores on the Career Planning Program (CPP) and the Multiple Assessment and Program Services (MAPS) placement tests. In addition, the relationship was examined between the first-quarter English…

  7. Determining the Essential Components of State and Institution Dual Credit Program Policy in New Mexico: A Delphi Study with High School and College Experts

    ERIC Educational Resources Information Center

    Carlson, Gregory Dean

    2013-01-01

    The purpose of this Delphi study was to determine the essential components of dual credit in New Mexico. Dual credit experts from colleges and high schools in New Mexico were asked to participate in a three-round Delphi study to determine what the future policy of dual credit should be, and why it should be that way. Definitions of dual credit may…

  8. The interactive web-based program MSmonitor for self-management and multidisciplinary care in multiple sclerosis: utilization and valuation by patients

    PubMed Central

    Jongen, Peter Joseph; Sinnige, Ludovicus G; van Geel, Björn M; Verheul, Freek; Verhagen, Wim I; van der Kruijk, Ruud A; Haverkamp, Reinoud; Schrijver, Hans M; Baart, Jacoba C; Visser, Leo H; Arnoldus, Edo P; Gilhuis, Herman Jacobus; Pop, Paul; Booy, Monique; Heerings, Marco; Kool, Anton; van Noort, Esther

    2016-01-01

    Background MSmonitor is an interactive web-based program for self-management and integrated, multidisciplinary care in multiple sclerosis. Methods To assess the utilization and valuation by persons with multiple sclerosis, we held an online survey among those who had used the program for at least 1 year. We evaluated the utilization and meaningfulness of the program’s elements, perceived use of data by neurologists and nurses, and appreciation of care, self-management, and satisfaction. Results Fifty-five persons completed the questionnaire (estimated response rate 40%). The Multiple Sclerosis Impact Profile (MSIP), Medication and Adherence Inventory, Activities Diary, and electronic consultation (e-consult) were used by 40%, 55%, 47%, and 44% of respondents and were considered meaningful by 83%, 81%, 54%, and 88%, respectively. During out-patient consultations, nurses reportedly used the MSmonitor data three to six times more frequently than neurologists. As to nursing care, more symptoms were dealt with (according to 54% of respondents), symptoms were better discussed (69%), and the overall quality of care had improved (60%) since the use of the program. As to neurological care, these figures were 24%, 31%, and 27%, respectively. In 46% of the respondents, the insight into their symptoms and disabilities had increased since the use of the program; the MSIP, Activities Diary, and e-consult had contributed most to this improvement. The overall satisfaction with the program was 3.5 out of 5, and 73% of the respondents would recommend the program to other persons with multiple sclerosis. Conclusion A survey among persons with multiple sclerosis using the MSmonitor program showed that the MSIP, Medication and Adherence Inventory, Activities Diary, and e-consult were frequently used and that the MSIP, Medication and Adherence Inventory, and e-consult were appreciated the most. Moreover, the quality of nursing care, but not so neurological care, had improved, which

  9. The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells.

    PubMed

    Mair, Florian; Joller, Stefanie; Hoeppli, Romy; Onder, Lucas; Hahn, Matthias; Ludewig, Burkhard; Waisman, Ari; Becher, Burkhard

    2015-01-01

    γδ T cells contribute to first line immune defense, particularly through their ability for rapid production of proinflammatory cytokines. The cytokine profile of γδ T cells is hard-wired already during thymic development. Yet, the molecular pathways underlying this phenomenon are incompletely understood. Here we show that signaling via the NFκB-inducing kinase (NIK) is essential for the formation of a fully functional γδ T cell compartment. In the absence of NIK, development of Vγ5(+) dendritic epidermal T cells (DETCs) was halted in the embryonic thymus, and impaired NIK function caused a selective loss of IL-17 expression by γδ T cells. Using a novel conditional mutant of NIK, we could show in vivo that NIK signaling in thymic epithelial cells is essential for the thymic hardwiring of γδ T cell cytokine production. PMID:26637788

  10. Essential Skills of the K?12 CTO

    ERIC Educational Resources Information Center

    Learning & Leading with Technology, 2005

    2005-01-01

    The job of overseeing a school district's technology program has grown exponentially in recent years as computers, the Internet, and other technology applications have become essential to the daily operation of schools. What are the essential skills needed to oversee a school district's technology program? The Consortium for School Networking…

  11. Systemic reform of the science program in the middle grades: A descriptive multiple case study in two Chicago public schools

    NASA Astrophysics Data System (ADS)

    Mercado, Roberto

    This multiple case study described, analyzed, and interpreted the process of systemic reform of the science education program in the middle grades. Two Chicago public schools implementing a systemic reform initiative over 4 years were randomly selected. Data were collected and triangulated from interviews, questionnaires, documents, and field observations. School administrators, science teachers, parents, and other staff members participated in this study. The context of individual schools was examined separately and conclusions drawn from individual cases and from the cross-case analysis and synthesis. Results showed that schools in this study were struggling with the process of systemic reform. This struggle was characterized by a lack of capacity for systemic reform. This lack of capacity was mainly caused by a fragmented science education system and inadequate approaches to teacher development. Therefore, it was recommended that schools build capacity for change to meet the demands set forth in the national science education standards. To do so, schools should engage in professional development practices that transform them into inquiry-based communities. Such a community can inform its practice to influence system-wide policies for education. One implication of this study is that school systems should set a mission and formulate policies consistent with the national vision of a scientifically literate citizen.

  12. Multiple Sclerosis: Changes in Thalamic Resting-State Functional Connectivity Induced by a Home-based Cognitive Rehabilitation Program.

    PubMed

    De Giglio, Laura; Tona, Francesca; De Luca, Francesca; Petsas, Nikolaos; Prosperini, Luca; Bianchi, Valentina; Pozzilli, Carlo; Pantano, Patrizia

    2016-07-01

    Purpose To investigate thalamic connectivity changes after use of a video game-based cognitive rehabilitation program, as thalamic damage and alterations in thalamocortical functional connectivity (FC) are important factors in cognitive dysfunction in patients with multiple sclerosis (MS). Materials and Methods This prospective study was approved by the local ethical committee. Twenty-four patients with MS and cognitive impairment were randomly assigned to either an intervention or a wait-list group. Patients were evaluated with cognitive tests and 3-T resting-state functional magnetic resonance (MR) imaging at baseline and after an 8-week period. In addition, 11 healthy subjects underwent baseline resting-state functional MR imaging. Patients in the intervention group performed the video game-based cognitive rehabilitation program, while those in the wait-list group served as control subjects. Repeated measures analysis of variance was used to test efficacy of the intervention. The thalamic resting-state network was identified with a seed-based method; both first-level and high-level analyses were performed by using software tools. Results Patients showed lower baseline FC compared with healthy subjects. A significant improvement was seen in results of the Paced Auditory Serial Addition Test and the Stroop Test after 8 weeks of cognitive rehabilitation (F = 6.616, [P = .018] and F = 5.325 [P = .030], respectively). At follow-up, the intervention group had an increased FC in the cingulum, precuneus, and bilateral parietal cortex and a lower FC in the cerebellum and in left prefrontal cortex compared with the wait-list group (P < .05, family-wise error corrected); correlations were found between FC changes in these regions and cognitive improvement (P < .05, family-wise error corrected). Conclusion The results of this study show the relevance of thalamic regulation of the brain networks involved in cognition and suggest that changes in thalamic resting-state network

  13. National Environmental/Energy Workforce Assessment, Phase II, Post-Secondary Education Profile: Wastewater II (Multiple Degree Programs).

    ERIC Educational Resources Information Center

    National Field Research Center Inc., Iowa City, IA.

    This report, together with volume I (single degree programs), detail 105 post-secondary wastewater treatment programs from 33 states. These programs represent a sample, only, of the various programs available nationwide. Enrollment and graduate statistics are presented. The total number of faculty involved in all the programs surveyed was 1,106;…

  14. An Adaptive Dynamic Pointing Assistance Program to Help People with Multiple Disabilities Improve Their Computer Pointing Efficiency with Hand Swing through a Standard Mouse

    ERIC Educational Resources Information Center

    Shih, Ching-Hsiang; Shih, Ching-Tien; Wu, Hsiao-Ling

    2010-01-01

    The latest research adopted software technology to redesign the mouse driver, and turned a mouse into a useful pointing assistive device for people with multiple disabilities who cannot easily or possibly use a standard mouse, to improve their pointing performance through a new operation method, Extended Dynamic Pointing Assistive Program (EDPAP),…

  15. Technology-Based Programs to Promote Walking Fluency or Improve Foot-Ground Contact during Walking: Two Case Studies of Adults with Multiple Disabilities

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; La Martire, Maria L.; Oliva, Doretta; Groeneweg, Jop

    2012-01-01

    These two case studies assessed technology-based programs for promoting walking fluency and improving foot-ground contact during walking with a man and a woman with multiple disabilities, respectively. The man showed breaks during walking and the woman presented with toe walking. The technology used in the studies included a microprocessor with…

  16. Comparison of Effects of Teaching English to Thai Undergraduate Teacher-Students through Cross-Curricular Thematic Instruction Program Based on Multiple Intelligence Theory and Conventional Instruction

    ERIC Educational Resources Information Center

    Rattanavich, Saowalak

    2013-01-01

    This study is aimed at comparing the effects of teaching English to Thai undergraduate teacher-students through cross-curricular thematic instruction program based on multiple intelligence theory and through conventional instruction. Two experimental groups, which utilized Randomized True Control Group-Pretest-posttest Time Series Design and…

  17. Persons with Multiple Disabilities Exercise Adaptive Response Schemes with the Help of Technology-Based Programs: Three Single-Case Studies

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Oliva, Doretta; Campodonico, Francesca; Lang, Russell

    2012-01-01

    The present three single-case studies assessed the effectiveness of technology-based programs to help three persons with multiple disabilities exercise adaptive response schemes independently. The response schemes included (a) left and right head movements for a man who kept his head increasingly static on his wheelchair's headrest (Study I), (b)…

  18. Essential biodiversity variables

    USGS Publications Warehouse

    Pereira, H.M.; Ferrier, S.; Walters, M.; Geller, G.N.; Jongman, R.H.G.; Scholes, R.J.; Bruford, M.W.; Brummitt, N.; Butchart, S.H.M.; Cardoso, A.C.; Coops, N.C.; Dulloo, E.; Faith, D.P.; Freyhof, J.; Gregory, R.D.; Heip, C.; Höft, R.; Hurtt, G.; Jetz, W.; Karp, D.S.; McGeoch, M.A.; Obura, D.; Onada, Y.; Pettorelli, N.; Reyers, B.; Sayre, R.; Scharlemann, J.P.W.; Stuart, S.N.; Turak, E.; Walpole, M.; Wegmann, M.

    2013-01-01

    Reducing the rate of biodiversity loss and averting dangerous biodiversity change are international goals, reasserted by the Aichi Targets for 2020 by Parties to the United Nations (UN) Convention on Biological Diversity (CBD) after failure to meet the 2010 target (1, 2). However, there is no global, harmonized observation system for delivering regular, timely data on biodiversity change (3). With the first plenary meeting of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) soon under way, partners from the Group on Earth Observations Biodiversity Observation Network (GEO BON) (4) are developing—and seeking consensus around—Essential Biodiversity Variables (EBVs) that could form the basis of monitoring programs worldwide.

  19. Effects of a 10-Week Inspiratory Muscle Training Program on Lower-Extremity Mobility in People with Multiple Sclerosis

    PubMed Central

    Fry, Donna

    2011-01-01

    Pulmonary muscle weakness is common in ambulatory people with multiple sclerosis (MS) and may lead to deficits in mobility function. The purpose of this study was to examine the effect of a 10-week home-based exercise program using an inspiratory muscle threshold trainer (IMT) on the results of four lower-extremity physical performance tests in people with MS. The study design was a two-group (experimental-control), pretest-posttest study. Outcome measures consisted of pulmonary function measures including maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and maximal voluntary ventilation (MVV), and the following lower-extremity physical performance measures: the 6-Minute Walk (6MW) distance, gait velocity (GV), the Sit-to-Stand Test (SST), the Functional Stair Test (FST), and a balance test (BAL). A total of 46 ambulatory participants (Expanded Disability Status Scale [EDSS] score, 2.0–6.5) with MS were randomly assigned to an intervention group (mean EDSS score, 4.1) that received 10 weeks of home-based inspiratory muscle training or a nontreatment control group (mean EDSS score, 3.2). Of the original 46 participants, 20 intervention group participants and 19 control group participants completed the study. Compared with the control group, the intervention group made significantly greater gains in inspiratory muscle strength (P = .003) and timed balance scores (P = .008). A nonsignificant improvement in 6MW distance (P = .086) was also noted in the IMT-trained group as compared with the control group. This is the first study directly linking improvement in respiratory function to improvement in physical performance function in people with mild-to-moderate disability due to MS. PMID:24453703

  20. Towards a New Pluralism in ABE/ESOL Programs: Teaching to Multiple "Cultures of Mind." NCSALL Research Brief.

    ERIC Educational Resources Information Center

    Kegan, Robert; Broderick, Maria; Drago-Severson, Eleanor; Helsing, Deborah; Popp, Nancy; Portnow, Kathryn

    A study explored how adults perceived program learning; whether program learning helped them enact a particular social role; and whether they changed while participating in the program. For a year or more, researchers studied experiences of learning and change of 41 adult learners enrolled in three programs--at a community college, family literacy…

  1. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

    PubMed Central

    Zuber, Johannes; Rappaport, Amy R.; Luo, Weijun; Wang, Eric; Chen, Chong; Vaseva, Angelina V.; Shi, Junwei; Weissmueller, Susann; Fellman, Christof; Taylor, Meredith J.; Weissenboeck, Martina; Graeber, Thomas G.; Kogan, Scott C.; Vakoc, Christopher R.; Lowe, Scott W.

    2011-01-01

    Although human cancers have complex genotypes and are genomically unstable, they often remain dependent on the continued presence of single-driver mutations—a phenomenon dubbed “oncogene addiction.” Such dependencies have been demonstrated in mouse models, where conditional expression systems have revealed that oncogenes able to initiate cancer are often required for tumor maintenance and progression, thus validating the pathways they control as therapeutic targets. Here, we implement an integrative approach that combines genetically defined mouse models, transcriptional profiling, and a novel inducible RNAi platform to characterize cellular programs that underlie addiction to MLL-AF9—a fusion oncoprotein involved in aggressive forms of acute myeloid leukemia (AML). We show that MLL-AF9 contributes to leukemia maintenance by enforcing a Myb-coordinated program of aberrant self-renewal involving genes linked to leukemia stem cell potential and poor prognosis in human AML. Accordingly, partial and transient Myb suppression precisely phenocopies MLL-AF9 withdrawal and eradicates aggressive AML in vivo without preventing normal myelopoiesis, indicating that strategies to inhibit Myb-dependent aberrant self-renewal programs hold promise as effective and cancer-specific therapeutics. Together, our results identify Myb as a critical mediator of oncogene addiction in AML, delineate relevant Myb target genes that are amenable to pharmacologic inhibition, and establish a general approach for dissecting oncogene addiction in vivo. PMID:21828272

  2. An inexact fuzzy-chance-constrained two-stage mixed-integer linear programming approach for flood diversion planning under multiple uncertainties

    NASA Astrophysics Data System (ADS)

    Guo, P.; Huang, G. H.; Li, Y. P.

    2010-01-01

    In this study, an inexact fuzzy-chance-constrained two-stage mixed-integer linear programming (IFCTIP) approach is developed for flood diversion planning under multiple uncertainties. A concept of the distribution with fuzzy boundary interval probability is defined to address multiple uncertainties expressed as integration of intervals, fuzzy sets and probability distributions. IFCTIP integrates the inexact programming, two-stage stochastic programming, integer programming and fuzzy-stochastic programming within a general optimization framework. IFCTIP incorporates the pre-regulated water-diversion policies directly into its optimization process to analyze various policy scenarios; each scenario has different economic penalty when the promised targets are violated. More importantly, it can facilitate dynamic programming for decisions of capacity-expansion planning under fuzzy-stochastic conditions. IFCTIP is applied to a flood management system. Solutions from IFCTIP provide desired flood diversion plans with a minimized system cost and a maximized safety level. The results indicate that reasonable solutions are generated for objective function values and decision variables, thus a number of decision alternatives can be generated under different levels of flood flows.

  3. Retention Indices for Frequently Reported Compounds of Plant Essential Oils

    NASA Astrophysics Data System (ADS)

    Babushok, V. I.; Linstrom, P. J.; Zenkevich, I. G.

    2011-12-01

    Gas chromatographic retention indices were evaluated for 505 frequently reported plant essential oil components using a large retention index database. Retention data are presented for three types of commonly used stationary phases: dimethyl silicone (nonpolar), dimethyl silicone with 5% phenyl groups (slightly polar), and polyethylene glycol (polar) stationary phases. The evaluations are based on the treatment of multiple measurements with the number of data records ranging from about 5 to 800 per compound. Data analysis was limited to temperature programmed conditions. The data reported include the average and median values of retention index with standard deviations and confidence intervals.

  4. Multiple Sclerosis.

    ERIC Educational Resources Information Center

    Plummer, Nancy; Michael, Nancy, Ed.

    This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

  5. The Rich Gets Richer: Multiple Sources of Qualitative Data in an Evaluation of School-Based Health Promotion Programs.

    ERIC Educational Resources Information Center

    Loesch-Griffin, Deborah A.; And Others

    A report is given of the problems and successes of an evaluation team engaged in examining a 9-year community research demonstration project. The project, the Stanford Heart Disease Prevention Program, was designed to develop effective health education programs and to institutionalize these programs through community organizations so that they are…

  6. Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.

    PubMed

    Karunarathne, Deshapriya S; Horne-Debets, Joshua M; Huang, Johnny X; Faleiro, Rebecca; Leow, Chiuan Yee; Amante, Fiona; Watkins, Thomas S; Miles, John J; Dwyer, Patrick J; Stacey, Katryn J; Yarski, Michael; Poh, Chek Meng; Lee, Jason S; Cooper, Matthew A; Rénia, Laurent; Richard, Derek; McCarthy, James S; Sharpe, Arlene H; Wykes, Michelle N

    2016-08-16

    Many pathogens, including Plasmodium spp., exploit the interaction of programmed death-1 (PD-1) with PD-1-ligand-1 (PD-L1) to "deactivate" T cell functions, but the role of PD-L2 remains unclear. We studied malarial infections to understand the contribution of PD-L2 to immunity. Here we have shown that higher PD-L2 expression on blood dendritic cells, from Plasmodium falciparum-infected individuals, correlated with lower parasitemia. Mechanistic studies in mice showed that PD-L2 was indispensable for establishing effective CD4(+) T cell immunity against malaria, because it not only inhibited PD-L1 to PD-1 activity but also increased CD3 and inducible co-stimulator (ICOS) expression on T cells. Importantly, administration of soluble multimeric PD-L2 to mice with lethal malaria was sufficient to dramatically improve immunity and survival. These studies show immuno-regulation by PD-L2, which has the potential to be translated into an effective treatment for malaria and other diseases where T cell immunity is ineffective or short-lived due to PD-1-mediated signaling. PMID:27533014

  7. Developing Essential Understanding of Rational Numbers for Teaching Mathematics in Grades 3-5. Essential Understandings

    ERIC Educational Resources Information Center

    Clarke, Carne; Fisher, William; Marks, Rick; Ross, Sharon; Zbiek, Rose Mary

    2010-01-01

    This book focuses on essential knowledge for teachers about rational numbers. It is organized around four big ideas, supported by multiple smaller, interconnected ideas--essential understandings. Taking teachers beyond a simple introduction to rational numbers, the book will broaden and deepen their mathematical understanding of one of the most…

  8. Reconciling the Multiple Objectives of Prison Diversion Programs for Drug Offenders: Evidence from Kansas' Senate Bill 123

    ERIC Educational Resources Information Center

    Stemen, Don; Rengifo, Andres F.

    2011-01-01

    Background: In recent years, several states have created mandatory prison-diversion programs for felony drug possessors. These programs have both individual-level goals of reducing recidivism rates and system-level goals of reducing prison populations. Objective: This study examines the individual level and system level impact of Kansas' Senate…

  9. Using Multiple Youth Programming Delivery Modes to Drive the Development of Social Capital in 4-H Participants

    ERIC Educational Resources Information Center

    Kinsey, Sharon

    2013-01-01

    This article focuses on how 4-H youth participants are building social capital, or connections among individuals and community members, through their 4-H experiences. These experiences can be seen through the lens of such 4-H delivery modes as the traditional 4-H club, after-school programs, and school enrichment programs. In addition, other…

  10. Documentation of a multiple-technique computer program for plotting major-ion composition of natural waters

    USGS Publications Warehouse

    Briel, L.I.

    1993-01-01

    A computer program was written to produce 6 different types of water-quality diagrams--Piper, Stiff, pie, X-Y, boxplot, and Piper 3-D--from the same file of input data. The Piper 3-D diagram is a new method that projects values from the surface of a Piper plot into a triangular prism to show how variations in chemical composition can be related to variations in other water-quality variables. This program is an analytical tool to aid in the interpretation of data. This program is interactive, and the user can select from a menu the type of diagram to be produced and a large number of individual features. Alternatively, these choices can be specified in the data file, which provides a batch mode for running the program. The program does not display water-quality diagrams directly; plots are written to a file. Four different plot- file formats are available: device-independent metafiles, Adobe PostScript graphics files, and two Hewlett-Packard graphics language formats (7475 and 7586). An ASCII data-table file is also produced to document the computed values. This program is written in Fortran '77 and uses graphics subroutines from either the PRIOR AGTK or the DISSPLA graphics library. The program has been implemented on Prime series 50 and Data General Aviion computers within the USGS; portability to other computing systems depends on the availability of the graphics library.