Sample records for n-end rule relates

  1. The N-end rule pathway and regulation by proteolysis

    PubMed Central

    Varshavsky, Alexander

    2011-01-01

    The N-end rule relates the regulation of the in vivo half-life of a protein to the identity of its N-terminal residue. Degradation signals (degrons) that are targeted by the N-end rule pathway include a set called N-degrons. The main determinant of an N-degron is a destabilizing N-terminal residue of a protein. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system and consists of two branches, the Ac/N-end rule and the Arg/N-end rule pathways. The Ac/N-end rule pathway targets proteins containing Nα-terminally acetylated (Nt-acetylated) residues. The Arg/N-end rule pathway recognizes unacetylated N-terminal residues and involves N-terminal arginylation. Together, these branches target for degradation a majority of cellular proteins. For example, more than 80% of human proteins are cotranslationally Nt-acetylated. Thus, most proteins harbor a specific degradation signal, termed AcN-degron, from the moment of their birth. Specific N-end rule pathways are also present in prokaryotes and in mitochondria. Enzymes that produce N-degrons include methionine-aminopeptidases, caspases, calpains, Nt-acetylases, Nt-amidases, arginyl-transferases, and leucyl-transferases. Regulated degradation of specific proteins by the N-end rule pathway mediates a legion of physiological functions, including the sensing of heme, oxygen, and nitric oxide; selective elimination of misfolded proteins; the regulation of DNA repair, segregation, and condensation; the signaling by G proteins; the regulation of peptide import, fat metabolism, viral and bacterial infections, apoptosis, meiosis, spermatogenesis, neurogenesis, and cardiovascular development; and the functioning of adult organs, including the pancreas and the brain. Discovered 25 years ago, this pathway continues to be a fount of biological insights. PMID:21633985

  2. Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.

    PubMed

    Wadas, Brandon; Borjigin, Jimo; Huang, Zheping; Oh, Jang-Hyun; Hwang, Cheol-Sang; Varshavsky, Alexander

    2016-08-12

    Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep. N-terminal sequences of AANAT enzymes vary among vertebrates. Mechanisms that regulate the levels of AANAT are incompletely understood. Previous findings were consistent with the possibility that AANAT may be controlled through its degradation by the N-end rule pathway. By expressing the rat and human AANATs and their mutants not only in mammalian cells but also in the yeast Saccharomyces cerevisiae, and by taking advantage of yeast genetics, we show here that two "complementary" forms of rat AANAT are targeted for degradation by two "complementary" branches of the N-end rule pathway. Specifically, the N(α)-terminally acetylated (Nt-acetylated) Ac-AANAT is destroyed through the recognition of its Nt-acetylated N-terminal Met residue by the Ac/N-end rule pathway, whereas the non-Nt-acetylated AANAT is targeted by the Arg/N-end rule pathway, which recognizes the unacetylated N-terminal Met-Leu sequence of rat AANAT. We also show, by constructing lysine-to-arginine mutants of rat AANAT, that its degradation is mediated by polyubiquitylation of its Lys residue(s). Human AANAT, whose N-terminal sequence differs from that of rodent AANATs, is longer-lived than its rat counterpart and appears to be refractory to degradation by the N-end rule pathway. Together, these and related results indicate both a major involvement of the N-end rule pathway in the control of rodent AANATs and substantial differences in the regulation of rodent and human AANATs that stem from differences in their N-terminal sequences. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  3. PINK1 is degraded through the N-end rule pathway

    PubMed Central

    Yamano, Koji; Youle, Richard J

    2013-01-01

    PINK1, a mitochondrial serine/threonine kinase, is the product of a gene mutated in an autosomal recessive form of Parkinson disease. PINK1 is constitutively degraded by an unknown mechanism and stabilized selectively on damaged mitochondria where it can recruit the E3 ligase PARK2/PARKIN to induce mitophagy. Here, we show that, under steady-state conditions, endogenous PINK1 is constitutively and rapidly degraded by E3 ubiquitin ligases UBR1, UBR2 and UBR4 through the N-end rule pathway. Following precursor import into mitochondria, PINK1 is cleaved in the transmembrane segment by a mitochondrial intramembrane protease PARL generating an N-terminal destabilizing amino acid and then retrotranslocates from mitochondria to the cytosol for N-end recognition and proteasomal degradation. Thus, sequential actions of mitochondrial import, PARL-processing, retrotranslocation and recognition by N-end rule E3 enzymes for the ubiquitin proteosomal degradation defines the rapid PINK1 turnover. PINK1 steady-state elimination by the N-end rule identifies a novel organelle to cytoplasm turnover pathway that yields a mechanism to flag damaged mitochondria for autophagic elimination. PMID:24121706

  4. Emerging branches of the N-end rule pathways are revealing the sequence complexities of N-termini dependent protein degradation.

    PubMed

    Eldeeb, Mohamed A; Leitao, Luana C A; Fahlman, Richard P

    2018-06-01

    The N-end rule links the identity of the N-terminal amino acid of a protein to its in vivo half-life, as some N-terminal residues confer metabolic instability to a protein via their recognition by the cellular machinery that targets them for degradation. Since its discovery, the N-end rule has generally been defined as set of rules of whether an N-terminal residue is stabilizing or not. However, recent studies are revealing that the N-terminal code of amino acids conferring protein instability is more complex than previously appreciated, as recent investigations are revealing that the identity of adjoining downstream residues can also influence the metabolic stability of N-end rule substrate. This is exemplified by the recent discovery of a new branch of N-end rule pathways that target proteins bearing N-terminal proline. In addition, recent investigations are demonstrating that the molecular machinery in N-termini dependent protein degradation may also target proteins for lysosomal degradation, in addition to proteasome-dependent degradation. Herein, we describe some of the recent advances in N-end rule pathways and discuss some of the implications regarding the emerging additional sequence requirements.

  5. The N-end rule pathway regulates pathogen responses in plants

    PubMed Central

    de Marchi, Rémi; Sorel, Maud; Mooney, Brian; Fudal, Isabelle; Goslin, Kevin; Kwaśniewska, Kamila; Ryan, Patrick T.; Pfalz, Marina; Kroymann, Juergen; Pollmann, Stephan; Feechan, Angela; Wellmer, Frank; Rivas, Susana; Graciet, Emmanuelle

    2016-01-01

    To efficiently counteract pathogens, plants rely on a complex set of immune responses that are tightly regulated to allow the timely activation, appropriate duration and adequate amplitude of defense programs. The coordination of the plant immune response is known to require the activity of the ubiquitin/proteasome system, which controls the stability of proteins in eukaryotes. Here, we demonstrate that the N-end rule pathway, a subset of the ubiquitin/proteasome system, regulates the defense against a wide range of bacterial and fungal pathogens in the model plant Arabidopsis thaliana. We show that this pathway positively regulates the biosynthesis of plant-defense metabolites such as glucosinolates, as well as the biosynthesis and response to the phytohormone jasmonic acid, which plays a key role in plant immunity. Our results also suggest that the arginylation branch of the N-end rule pathway regulates the timing and amplitude of the defense program against the model pathogen Pseudomonas syringae AvrRpm1. PMID:27173012

  6. The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins

    PubMed Central

    Jiang, Yanxialei; Lee, Jeeyoung; Lee, Jung Hoon; Lee, Joon Won; Kim, Ji Hyeon; Choi, Won Hoon; Yoo, Young Dong; Cha-Molstad, Hyunjoo; Kim, Bo Yeon; Kwon, Yong Tae; Noh, Sue Ah; Kim, Kwang Pyo; Lee, Min Jae

    2016-01-01

    ABSTRACT The N-terminal amino acid of a protein is an essential determinant of ubiquitination and subsequent proteasomal degradation in the N-end rule pathway. Using para-chloroamphetamine (PCA), a specific inhibitor of the arginylation branch of the pathway (Arg/N-end rule pathway), we identified that blocking the Arg/N-end rule pathway significantly impaired the fusion of autophagosomes with lysosomes. Under ER stress, ATE1-encoded Arg-tRNA-protein transferases carry out the N-terminal arginylation of the ER heat shock protein HSPA5 that initially targets cargo proteins, along with SQSTM1, to the autophagosome. At the late stage of autophagy, however, proteasomal degradation of arginylated HSPA5 might function as a critical checkpoint for the proper progression of autophagic flux in the cells. Consistently, the inhibition of the Arg/N-end rule pathway with PCA significantly elevated levels of MAPT and huntingtin aggregates, accompanied by increased numbers of LC3 and SQSTM1 puncta. Cells treated with the Arg/N-end rule inhibitor became more sensitized to proteotoxic stress-induced cytotoxicity. SILAC-based quantitative proteomics also revealed that PCA significantly alters various biological pathways, including cellular responses to stress, nutrient, and DNA damage, which are also closely involved in modulation of autophagic responses. Thus, our results indicate that the Arg/N-end rule pathway may function to actively protect cells from detrimental effects of cellular stresses, including proteotoxic protein accumulation, by positively regulating autophagic flux. PMID:27560450

  7. Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6.

    PubMed

    Mendiondo, Guillermina M; Gibbs, Daniel J; Szurman-Zubrzycka, Miriam; Korn, Arnd; Marquez, Julietta; Szarejko, Iwona; Maluszynski, Miroslaw; King, John; Axcell, Barry; Smart, Katherine; Corbineau, Francoise; Holdsworth, Michael J

    2016-01-01

    Increased tolerance of crops to low oxygen (hypoxia) during flooding is a key target for food security. In Arabidopsis thaliana (L.) Heynh., the N-end rule pathway of targeted proteolysis controls plant responses to hypoxia by regulating the stability of group VII ethylene response factor (ERFVII) transcription factors, controlled by the oxidation status of amino terminal (Nt)-cysteine (Cys). Here, we show that the barley (Hordeum vulgare L.) ERFVII BERF1 is a substrate of the N-end rule pathway in vitro. Furthermore, we show that Nt-Cys acts as a sensor for hypoxia in vivo, as the stability of the oxygen-sensor reporter protein MCGGAIL-GUS increased in waterlogged transgenic plants. Transgenic RNAi barley plants, with reduced expression of the N-end rule pathway N-recognin E3 ligase PROTEOLYSIS6 (HvPRT6), showed increased expression of hypoxia-associated genes and altered seed germination phenotypes. In addition, in response to waterlogging, transgenic plants showed sustained biomass, enhanced yield, retention of chlorophyll, and enhanced induction of hypoxia-related genes. HvPRT6 RNAi plants also showed reduced chlorophyll degradation in response to continued darkness, often associated with waterlogged conditions. Barley Targeting Induced Local Lesions IN Genomes (TILLING) lines, containing mutant alleles of HvPRT6, also showed increased expression of hypoxia-related genes and phenotypes similar to RNAi lines. We conclude that the N-end rule pathway represents an important target for plant breeding to enhance tolerance to waterlogging in barley and other cereals. © 2015 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  8. The N-end rule pathway catalyzes a major fraction of the protein degradation in skeletal muscle

    NASA Technical Reports Server (NTRS)

    Solomon, V.; Lecker, S. H.; Goldberg, A. L.

    1998-01-01

    In skeletal muscle, overall protein degradation involves the ubiquitin-proteasome system. One property of a protein that leads to rapid ubiquitin-dependent degradation is the presence of a basic, acidic, or bulky hydrophobic residue at its N terminus. However, in normal cells, substrates for this N-end rule pathway, which involves ubiquitin carrier protein (E2) E214k and ubiquitin-protein ligase (E3) E3alpha, have remained unclear. Surprisingly, in soluble extracts of rabbit muscle, we found that competitive inhibitors of E3alpha markedly inhibited the 125I-ubiquitin conjugation and ATP-dependent degradation of endogenous proteins. These inhibitors appear to selectively inhibit E3alpha, since they blocked degradation of 125I-lysozyme, a model N-end rule substrate, but did not affect the degradation of proteins whose ubiquitination involved other E3s. The addition of several E2s or E3alpha to the muscle extracts stimulated overall proteolysis and ubiquitination, but only the stimulation by E3alpha or E214k was sensitive to these inhibitors. A similar general inhibition of ubiquitin conjugation to endogenous proteins was observed with a dominant negative inhibitor of E214k. Certain substrates of the N-end rule pathway are degraded after their tRNA-dependent arginylation. We found that adding RNase A to muscle extracts reduced the ATP-dependent proteolysis of endogenous proteins, and supplying tRNA partially restored this process. Finally, although in muscle extracts the N-end rule pathway catalyzes most ubiquitin conjugation, it makes only a minor contribution to overall protein ubiquitination in HeLa cell extracts.

  9. The Cys-Arg/N-End Rule Pathway Is a General Sensor of Abiotic Stress in Flowering Plants.

    PubMed

    Vicente, Jorge; Mendiondo, Guillermina M; Movahedi, Mahsa; Peirats-Llobet, Marta; Juan, Yu-Ting; Shen, Yu-Yen; Dambire, Charlene; Smart, Katherine; Rodriguez, Pedro L; Charng, Yee-Yung; Gray, Julie E; Holdsworth, Michael J

    2017-10-23

    Abiotic stresses impact negatively on plant growth, profoundly affecting yield and quality of crops. Although much is known about plant responses, very little is understood at the molecular level about the initial sensing of environmental stress. In plants, hypoxia (low oxygen, which occurs during flooding) is directly sensed by the Cys-Arg/N-end rule pathway of ubiquitin-mediated proteolysis, through oxygen-dependent degradation of group VII Ethylene Response Factor transcription factors (ERFVIIs) via amino-terminal (Nt-) cysteine [1, 2]. Using Arabidopsis (Arabidopsis thaliana) and barley (Hordeum vulgare), we show that the pathway regulates plant responses to multiple abiotic stresses. In Arabidopsis, genetic analyses revealed that response to these stresses is controlled by N-end rule regulation of ERFVII function. Oxygen sensing via the Cys-Arg/N-end rule in higher eukaryotes is linked through a single mechanism to nitric oxide (NO) sensing [3, 4]. In plants, the major mechanism of NO synthesis is via NITRATE REDUCTASE (NR), an enzyme of nitrogen assimilation [5]. Here, we identify a negative relationship between NR activity and NO levels and stabilization of an artificial Nt-Cys substrate and ERFVII function in response to environmental changes. Furthermore, we show that ERFVIIs enhance abiotic stress responses via physical and genetic interactions with the chromatin-remodeling ATPase BRAHMA. We propose that plants sense multiple abiotic stresses through the Cys-Arg/N-end rule pathway either directly (via oxygen sensing) or indirectly (via NO sensing downstream of NR activity). This single mechanism can therefore integrate environment and response to enhance plant survival. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  10. The Greening after Extended Darkness1 Is an N-End Rule Pathway Mutant with High Tolerance to Submergence and Starvation1[OPEN

    PubMed Central

    Riber, Willi; Müller, Jana T.; Visser, Eric J.W.; Sasidharan, Rashmi; Voesenek, Laurentius A.C.J.; Mustroph, Angelika

    2015-01-01

    Plants respond to reductions in internal oxygen concentrations with adaptive mechanisms (for example, modifications of metabolism to cope with reduced supply of ATP). These responses are, at the transcriptional level, mediated by the group VII Ethylene Response Factor transcription factors, which have stability that is regulated by the N-end rule pathway of protein degradation. N-end rule pathway mutants are characterized by a constitutive expression of hypoxia response genes and abscisic acid hypersensitivity. Here, we identify a novel proteolysis6 (prt6) mutant allele, named greening after extended darkness1 (ged1), which was previously discovered in a screen for genomes uncoupled-like mutants and shows the ability to withstand long periods of darkness at the seedling stage. Interestingly, this ethyl methanesulfonate-derived mutant shows unusual chromosomal rearrangement instead of a point mutation. Furthermore, the sensitivity of N-end rule pathway mutants ged1 and prt6-1 to submergence was studied in more detail to understand previously contradicting experiments on this topic. Finally, it was shown that mutants for the N-end rule pathway are generally more tolerant to starvation conditions, such as prolonged darkness or submergence, which was partially associated with carbohydrate conservation. PMID:25667318

  11. Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway

    NASA Technical Reports Server (NTRS)

    Solomon, V.; Baracos, V.; Sarraf, P.; Goldberg, A. L.

    1998-01-01

    The rapid loss of muscle mass that accompanies many disease states, such as cancer or sepsis, is primarily a result of increased protein breakdown in muscle, and several observations have suggested an activation of the ubiquitin-proteasome system. Accordingly, in extracts of atrophying muscles from tumor-bearing or septic rats, rates of 125I-ubiquitin conjugation to endogenous proteins were found to be higher than in control extracts. On the other hand, in extracts of muscles from hypothyroid rats, where overall proteolysis is reduced below normal, the conjugation of 125I-ubiquitin to soluble proteins decreased by 50%, and treatment with triiodothyronine (T3) restored ubiquitination to control levels. Surprisingly, the N-end rule pathway, which selectively degrades proteins with basic or large hydrophobic N-terminal residues, was found to be responsible for most of these changes in ubiquitin conjugation. Competitive inhibitors of this pathway that specifically block the ubiquitin ligase, E3alpha, suppressed most of the increased ubiquitin conjugation in the muscle extracts from tumor-bearing and septic rats. These inhibitors also suppressed ubiquitination in normal extracts toward levels in hypothyroid extracts, which showed little E3alpha-dependent ubiquitination. Thus, the inhibitors eliminated most of the differences in ubiquitination under these different pathological conditions. Moreover, 125I-lysozyme, a model N-end rule substrate, was ubiquitinated more rapidly in extracts from tumor-bearing and septic rats, and more slowly in those from hypothyroid rats, than in controls. Thus, the rate of ubiquitin conjugation increases in atrophying muscles, and these hormone- and cytokine-dependent responses are in large part due to activation of the N-end rule pathway.

  12. Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway

    PubMed Central

    Solomon, Vered; Baracos, Vickie; Sarraf, Pasha; Goldberg, Alfred L.

    1998-01-01

    The rapid loss of muscle mass that accompanies many disease states, such as cancer or sepsis, is primarily a result of increased protein breakdown in muscle, and several observations have suggested an activation of the ubiquitin–proteasome system. Accordingly, in extracts of atrophying muscles from tumor-bearing or septic rats, rates of 125I-ubiquitin conjugation to endogenous proteins were found to be higher than in control extracts. On the other hand, in extracts of muscles from hypothyroid rats, where overall proteolysis is reduced below normal, the conjugation of 125I-ubiquitin to soluble proteins decreased by 50%, and treatment with triiodothyronine (T3) restored ubiquitination to control levels. Surprisingly, the N-end rule pathway, which selectively degrades proteins with basic or large hydrophobic N-terminal residues, was found to be responsible for most of these changes in ubiquitin conjugation. Competitive inhibitors of this pathway that specifically block the ubiquitin ligase, E3α, suppressed most of the increased ubiquitin conjugation in the muscle extracts from tumor-bearing and septic rats. These inhibitors also suppressed ubiquitination in normal extracts toward levels in hypothyroid extracts, which showed little E3α-dependent ubiquitination. Thus, the inhibitors eliminated most of the differences in ubiquitination under these different pathological conditions. Moreover, 125I-lysozyme, a model N-end rule substrate, was ubiquitinated more rapidly in extracts from tumor-bearing and septic rats, and more slowly in those from hypothyroid rats, than in controls. Thus, the rate of ubiquitin conjugation increases in atrophying muscles, and these hormone- and cytokine-dependent responses are in large part due to activation of the N-end rule pathway. PMID:9770532

  13. p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.

    PubMed

    Cha-Molstad, Hyunjoo; Yu, Ji Eun; Feng, Zhiwei; Lee, Su Hyun; Kim, Jung Gi; Yang, Peng; Han, Bitnara; Sung, Ki Woon; Yoo, Young Dong; Hwang, Joonsung; McGuire, Terry; Shim, Sang Mi; Song, Hyun Dong; Ganipisetti, Srinivasrao; Wang, Nuozhou; Jang, Jun Min; Lee, Min Jae; Kim, Seung Jun; Lee, Kyung Ho; Hong, Jin Tae; Ciechanover, Aaron; Mook-Jung, Inhee; Kim, Kwang Pyo; Xie, Xiang-Qun; Kwon, Yong Tae; Kim, Bo Yeon

    2017-07-24

    Macroautophagy mediates the selective degradation of proteins and non-proteinaceous cellular constituents. Here, we show that the N-end rule pathway modulates macroautophagy. In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N-recognin that binds type-1 and type-2 N-terminal degrons (N-degrons), including arginine (Nt-Arg). Both types of N-degrons bind its ZZ domain. By employing three-dimensional modeling, we developed synthetic ligands to p62 ZZ domain. The binding of Nt-Arg and synthetic ligands to ZZ domain facilitates disulfide bond-linked aggregation of p62 and p62 interaction with LC3, leading to the delivery of p62 and its cargoes to the autophagosome. Upon binding to its ligand, p62 acts as a modulator of macroautophagy, inducing autophagosome biogenesis. Through these dual functions, cells can activate p62 and induce selective autophagy upon the accumulation of autophagic cargoes. We also propose that p62 mediates the crosstalk between the ubiquitin-proteasome system and autophagy through its binding Nt-Arg and other N-degrons.Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin from the proteolytic N-end rule pathway, and targets these cargos to autophagosomal degradation.

  14. Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats

    PubMed Central

    Lecker, Stewart H.; Solomon, Vered; Price, S. Russ; Kwon, Yong Tae; Mitch, William E.; Goldberg, Alfred L.

    1999-01-01

    Insulin deficiency (e.g., in acute diabetes or fasting) is associated with enhanced protein breakdown in skeletal muscle leading to muscle wasting. Because recent studies have suggested that this increased proteolysis is due to activation of the ubiquitin-proteasome (Ub-proteasome) pathway, we investigated whether diabetes is associated with an increased rate of Ub conjugation to muscle protein. Muscle extracts from streptozotocin-induced insulin-deficient rats contained greater amounts of Ub-conjugated proteins than extracts from control animals and also 40–50% greater rates of conjugation of 125I-Ub to endogenous muscle proteins. This enhanced Ub-conjugation occurred mainly through the N-end rule pathway that involves E214k and E3α. A specific substrate of this pathway, α-lactalbumin, was ubiquitinated faster in the diabetic extracts, and a dominant negative form of E214k inhibited this increase in ubiquitination rates. Both E214k and E3α were shown to be rate-limiting for Ub conjugation because adding small amounts of either to extracts stimulated Ub conjugation. Furthermore, mRNA for E214k and E3α (but not E1) were elevated 2-fold in muscles from diabetic rats, although no significant increase in E214k and E3α content could be detected by immunoblot or activity assays. The simplest interpretation of these results is that small increases in both E214k and E3α in muscles of insulin-deficient animals together accelerate Ub conjugation and protein degradation by the N-end rule pathway, the same pathway activated in cancer cachexia, sepsis, and hyperthyroidism. J. Clin. Invest. 104:1411–1420 (1999). PMID:10562303

  15. Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats.

    PubMed

    Lecker, S H; Solomon, V; Price, S R; Kwon, Y T; Mitch, W E; Goldberg, A L

    1999-11-01

    Insulin deficiency (e.g., in acute diabetes or fasting) is associated with enhanced protein breakdown in skeletal muscle leading to muscle wasting. Because recent studies have suggested that this increased proteolysis is due to activation of the ubiquitin-proteasome (Ub-proteasome) pathway, we investigated whether diabetes is associated with an increased rate of Ub conjugation to muscle protein. Muscle extracts from streptozotocin-induced insulin-deficient rats contained greater amounts of Ub-conjugated proteins than extracts from control animals and also 40-50% greater rates of conjugation of (125)I-Ub to endogenous muscle proteins. This enhanced Ub-conjugation occurred mainly through the N-end rule pathway that involves E2(14k) and E3alpha. A specific substrate of this pathway, alpha-lactalbumin, was ubiquitinated faster in the diabetic extracts, and a dominant negative form of E2(14k) inhibited this increase in ubiquitination rates. Both E2(14k) and E3alpha were shown to be rate-limiting for Ub conjugation because adding small amounts of either to extracts stimulated Ub conjugation. Furthermore, mRNA for E2(14k) and E3alpha (but not E1) were elevated 2-fold in muscles from diabetic rats, although no significant increase in E2(14k) and E3alpha content could be detected by immunoblot or activity assays. The simplest interpretation of these results is that small increases in both E2(14k) and E3alpha in muscles of insulin-deficient animals together accelerate Ub conjugation and protein degradation by the N-end rule pathway, the same pathway activated in cancer cachexia, sepsis, and hyperthyroidism.

  16. Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats

    NASA Technical Reports Server (NTRS)

    Lecker, S. H.; Solomon, V.; Price, S. R.; Kwon, Y. T.; Mitch, W. E.; Goldberg, A. L.

    1999-01-01

    Insulin deficiency (e.g., in acute diabetes or fasting) is associated with enhanced protein breakdown in skeletal muscle leading to muscle wasting. Because recent studies have suggested that this increased proteolysis is due to activation of the ubiquitin-proteasome (Ub-proteasome) pathway, we investigated whether diabetes is associated with an increased rate of Ub conjugation to muscle protein. Muscle extracts from streptozotocin-induced insulin-deficient rats contained greater amounts of Ub-conjugated proteins than extracts from control animals and also 40-50% greater rates of conjugation of (125)I-Ub to endogenous muscle proteins. This enhanced Ub-conjugation occurred mainly through the N-end rule pathway that involves E2(14k) and E3alpha. A specific substrate of this pathway, alpha-lactalbumin, was ubiquitinated faster in the diabetic extracts, and a dominant negative form of E2(14k) inhibited this increase in ubiquitination rates. Both E2(14k) and E3alpha were shown to be rate-limiting for Ub conjugation because adding small amounts of either to extracts stimulated Ub conjugation. Furthermore, mRNA for E2(14k) and E3alpha (but not E1) were elevated 2-fold in muscles from diabetic rats, although no significant increase in E2(14k) and E3alpha content could be detected by immunoblot or activity assays. The simplest interpretation of these results is that small increases in both E2(14k) and E3alpha in muscles of insulin-deficient animals together accelerate Ub conjugation and protein degradation by the N-end rule pathway, the same pathway activated in cancer cachexia, sepsis, and hyperthyroidism.

  17. WellnessRules: A Web 3.0 Case Study in RuleML-Based Prolog-N3 Profile Interoperation

    NASA Astrophysics Data System (ADS)

    Boley, Harold; Osmun, Taylor Michael; Craig, Benjamin Larry

    An interoperation study, WellnessRules, is described, where rules about wellness opportunities are created by participants in rule languages such as Prolog and N3, and translated within a wellness community using RuleML/XML. The wellness rules are centered around participants, as profiles, encoding knowledge about their activities conditional on the season, the time-of-day, the weather, etc. This distributed knowledge base extends FOAF profiles with a vocabulary and rules about wellness group networking. The communication between participants is organized through Rule Responder, permitting wellness-profile translation and distributed querying across engines. WellnessRules interoperates between rules and queries in the relational (Datalog) paradigm of the pure-Prolog subset of POSL and in the frame (F-logic) paradigm of N3. An evaluation of Rule Responder instantiated for WellnessRules revealed acceptable Web response times.

  18. 29 CFR 825.602 - Special rules for school employees, limitations on leave near the end of an academic term.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... near the end of an academic term. 825.602 Section 825.602 Labor Regulations Relating to Labor... on leave near the end of an academic term. (a) There are also different rules for instructional... days. (b) For purposes of these provisions, academic term means the school semester, which typically...

  19. 29 CFR 825.602 - Special rules for school employees, limitations on leave near the end of an academic term.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... near the end of an academic term. 825.602 Section 825.602 Labor Regulations Relating to Labor... on leave near the end of an academic term. (a) There are also different rules for instructional... days. (b) For purposes of these provisions, academic term means the school semester, which typically...

  20. Communicating eating-related rules. Suggestions are more effective than restrictions.

    PubMed

    Stok, F Marijn; de Vet, Emely; de Wit, John B F; Renner, Britta; de Ridder, Denise T D

    2015-03-01

    A common social influence technique for curbing unhealthy eating behavior is to communicate eating-related rules (e.g. 'you should not eat unhealthy food'). Previous research has shown that such restrictive rules sometimes backfire and actually increase unhealthy consumption. In the current studies, we aimed to investigate if a milder form of social influence, a suggested rule, is more successful in curbing intake of unhealthy food. We also investigated how both types of rules affected psychological reactance. Students (N = 88 in Study 1, N = 51 in Study 2) completed a creativity task while a bowl of M&M's was within reach. Consumption was either explicitly forbidden (restrictive rule) or mildly discouraged (suggested rule). In the control condition, consumption was either explicitly allowed (Study 1) or M&M's were not provided (Study 2). Measures of reactance were assessed after the creativity task. Subsequently, a taste test was administered where all participants were allowed to consume M&M's. Across both studies, consumption during the creativity task did not differ between the restrictive- and suggested-rule-conditions, indicating that both are equally successful in preventing initial consumption. Restrictive-rule-condition participants reported higher reactance and consumed more in the free-eating taste-test phase than suggested-rule-condition participants and control-group participants, indicating a negative after-effect of restriction. RESULTS show that there are more and less effective ways to communicate eating-related rules. A restrictive rule, as compared to a suggested rule, induced psychological reactance and led to greater unhealthy consumption when participants were allowed to eat freely. It is important to pay attention to the way in which eating-related rules are communicated. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. 29 CFR 825.602 - Special rules for school employees, limitations on leave near the end of an academic term.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... near the end of an academic term. 825.602 Section 825.602 Labor Regulations Relating to Labor... on leave near the end of an academic term. (a) There are also different rules for instructional... days. (b) For purposes of these provisions, “academic term” means the school semester, which typically...

  2. 29 CFR 825.602 - Special rules for school employees, limitations on leave near the end of an academic term.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... near the end of an academic term. 825.602 Section 825.602 Labor Regulations Relating to Labor... on leave near the end of an academic term. (a) There are also different rules for instructional... days. (b) For purposes of these provisions, “academic term” means the school semester, which typically...

  3. 29 CFR 825.602 - Special rules for school employees, limitations on leave near the end of an academic term.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... near the end of an academic term. 825.602 Section 825.602 Labor Regulations Relating to Labor... on leave near the end of an academic term. (a) There are also different rules for instructional... days. (b) For purposes of these provisions, “academic term” means the school semester, which typically...

  4. The Relative Emphasis of Play Rules between Experienced and Trainee Caregivers of Toddlers

    ERIC Educational Resources Information Center

    Gyöngy, Kinga

    2017-01-01

    Content analysis of a large-scale (N = 920) qualitative data set with MAXQDA12 from a nationwide questionnaire of nursery practitioners in Hungary was able to demonstrate various types of rules during free play: social, health and safety, and environment-related rules. Environment-related rules, which govern space utilisation in toddler groups,…

  5. 12 CFR 1026.57 - Reporting and marketing rules for college student open-end credit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... TRUTH IN LENDING (REGULATION Z) Special Rules Applicable to Credit Card Accounts and Open-End Credit.... (a) Definitions—(1) College student credit card. The term “college student credit card” as used in this section means a credit card issued under a credit card account under an open-end (not home-secured...

  6. 12 CFR 226.57 - Reporting and marketing rules for college student open-end credit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to Credit Card Accounts and Open-End Credit Offered to College Students § 226.57 Reporting and marketing rules for college student open-end credit. (a) Definitions: (1) College student credit card. The term “college student credit card” as used in this section means a credit card issued under a credit...

  7. 12 CFR 1026.57 - Reporting and marketing rules for college student open-end credit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... TRUTH IN LENDING (REGULATION Z) Special Rules Applicable to Credit Card Accounts and Open-End Credit.... (a) Definitions—(1) College student credit card. The term “college student credit card” as used in this section means a credit card issued under a credit card account under an open-end (not home-secured...

  8. 12 CFR 1026.57 - Reporting and marketing rules for college student open-end credit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... TRUTH IN LENDING (REGULATION Z) Special Rules Applicable to Credit Card Accounts and Open-End Credit.... (a) Definitions. (1) College student credit card. The term “college student credit card” as used in this section means a credit card issued under a credit card account under an open-end (not home-secured...

  9. 12 CFR 226.57 - Reporting and marketing rules for college student open-end credit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Applicable to Credit Card Accounts and Open-End Credit Offered to College Students § 226.57 Reporting and marketing rules for college student open-end credit. (a) Definitions: (1) College student credit card. The term “college student credit card” as used in this section means a credit card issued under a credit...

  10. 12 CFR 226.57 - Reporting and marketing rules for college student open-end credit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to Credit Card Accounts and Open-End Credit Offered to College Students § 226.57 Reporting and marketing rules for college student open-end credit. (a) Definitions: (1) College student credit card. The term “college student credit card” as used in this section means a credit card issued under a credit...

  11. 12 CFR 226.57 - Reporting and marketing rules for college student open-end credit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Applicable to Credit Card Accounts and Open-End Credit Offered to College Students § 226.57 Reporting and marketing rules for college student open-end credit. (a) Definitions: (1) College student credit card. The term “college student credit card” as used in this section means a credit card issued under a credit...

  12. Infants learn a rule predicated on the relation same but fail to simultaneously learn a rule predicated on the relation different.

    PubMed

    Hochmann, Jean-Rémy; Carey, Susan; Mehler, Jacques

    2018-08-01

    In two experiments, we assessed whether infants are able to learn rules predicated on two abstract relations linked by negation: same and different (not same). In an anticipatory looking paradigm, the relation between successive colored geometrical shapes predicted the location where a puppet would appear next. In Experiment 1, 7-month-olds learned and generalized a rule predicated on the relation same, but not a rule predicated on the relation different. Similarly, in Experiment 2, 12-month-olds learned a rule predicated on the relation same-shape, but not a rule predicated on the relation different-shape. Comparing our data with that from previous experiments in the speech domain, we found no effect of age, modality or rule complexity. We conclude that, in the first year of life, infants already possess a representation of the abstract relation same, which serves as input to a rule. In contrast, we find no evidence that they represent the relation different. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. Rule-violations sensitise towards negative and authority-related stimuli.

    PubMed

    Wirth, Robert; Foerster, Anna; Rendel, Hannah; Kunde, Wilfried; Pfister, Roland

    2018-05-01

    Rule violations have usually been studied from a third-person perspective, identifying situational factors that render violations more or less likely. A first-person perspective of the agent that actively violates the rules, on the other hand, is only just beginning to emerge. Here we show that committing a rule violation sensitises towards subsequent negative stimuli as well as subsequent authority-related stimuli. In a Prime-Probe design, we used an instructed rule-violation task as the Prime and a word categorisation task as the Probe. Also, we employed a control condition that used a rule inversion task as the Prime (instead of rule violations). Probe targets were categorised faster after a violation relative to after a rule-based response if they related to either, negative valence or authority. Inversions, however, primed only negative stimuli and did not accelerate the categorisation of authority-related stimuli. A heightened sensitivity towards authority-related targets thus seems to be specific to rule violations. A control experiment showed that these effects cannot be explained in terms of semantic priming. Therefore, we propose that rule violations necessarily activate authority-related representations that make rule violations qualitatively different from simple rule inversions.

  14. The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.

    PubMed

    Ashton-Beaucage, Dariel; Lemieux, Caroline; Udell, Christian M; Sahmi, Malha; Rochette, Samuel; Therrien, Marc

    2016-08-01

    RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus. Disruption of this pathway is widely observed in cancer and other pathologies. Consequently, considerable effort has been devoted to understanding the mechanistic aspects of RAS-MAPK signal transmission and regulation. While much information has been garnered on the steps leading up to the activation and inactivation of core pathway components, comparatively little is known on the mechanisms controlling their expression and turnover. We recently identified several factors that dictate Drosophila MAPK levels. Here, we describe the function of one of these, the deubiquitinase (DUB) USP47. We found that USP47 acts post-translationally to counteract a proteasome-mediated event that reduces MAPK half-life and thereby dampens signaling output. Using an RNAi-based genetic interaction screening strategy, we identified UBC6, POE/UBR4, and UFD4, respectively, as E2 and E3 enzymes that oppose USP47 activity. Further characterization of POE-associated factors uncovered KCMF1 as another key component modulating MAPK levels. Together, these results identify a novel protein degradation module that governs MAPK levels. Given the role of UBR4 as an N-recognin ubiquitin ligase, our findings suggest that RAS-MAPK signaling in Drosophila is controlled by the N-end rule pathway and that USP47 counteracts its activity.

  15. Evaluating multiepisode events: boundary conditions for the peak-end rule.

    PubMed

    Miron-Shatz, Talya

    2009-04-01

    This study advances our understanding of how people arrive at retrospective evaluations of multiepisode experiences. Large samples from the United States, France, and Denmark (810, 820, and 805 participants, respectively) reported their feelings during each episode of the previous day using the Day Reconstruction Method. The duration-weighted average of these feelings represented the normative approach to evaluation, and, contrary to the predictions of the peak-end rule, the average was the best predictor of retrospective evaluations of the day. To capture participants' heuristic evaluation, they also reported having a wonderful (peak) and/or awful (low) moment during the previous day. The results indicate that retrospective evaluations of multiepisode events rely on the averaged ratings of emotions, ignore ends, and also consider the presence of lows, and occasionally peaks, as subjectively defined by those experiencing them. Peaks and lows contribute more to comparative, rather than absolute evaluations. Future research should examine whether these findings extend to other multiepisode events that, unlike days, form cohesive units in terms of their content, goal, and emotionality. (c) 2009 APA, all rights reserved.

  16. Promoter Sequences Prediction Using Relational Association Rule Mining

    PubMed Central

    Czibula, Gabriela; Bocicor, Maria-Iuliana; Czibula, Istvan Gergely

    2012-01-01

    In this paper we are approaching, from a computational perspective, the problem of promoter sequences prediction, an important problem within the field of bioinformatics. As the conditions for a DNA sequence to function as a promoter are not known, machine learning based classification models are still developed to approach the problem of promoter identification in the DNA. We are proposing a classification model based on relational association rules mining. Relational association rules are a particular type of association rules and describe numerical orderings between attributes that commonly occur over a data set. Our classifier is based on the discovery of relational association rules for predicting if a DNA sequence contains or not a promoter region. An experimental evaluation of the proposed model and comparison with similar existing approaches is provided. The obtained results show that our classifier overperforms the existing techniques for identifying promoter sequences, confirming the potential of our proposal. PMID:22563233

  17. Medicare program; End-Stage Renal Disease prospective payment system, quality incentive program, and Durable Medical Equipment, Prosthetics, Orthotics, and Supplies. Final rule.

    PubMed

    2014-11-06

    This final rule will update and make revisions to the End-Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2015. This rule also finalizes requirements for the ESRD quality incentive program (QIP), including for payment years (PYs) 2017 and 2018. This rule will also make a technical correction to remove outdated terms and definitions. In addition, this final rule sets forth the methodology for adjusting Durable Medical Equipment, Prosthetics, Orthotics, and Supplies (DMEPOS) fee schedule payment amounts using information from the Medicare DMEPOS Competitive Bidding Program (CBP); makes alternative payment rules for certain DME under the Medicare DMEPOS CBP; clarifies the statutory Medicare hearing aid coverage exclusion and specifies devices not subject to the hearing aid exclusion; will not update the definition of minimal self-adjustment; clarifies the Change of Ownership (CHOW) and provides for an exception to the current requirements; revises the appeal provisions for termination of a CBP contract, including the beneficiary notification requirement under the Medicare DMEPOS CBP, and makes a technical change to the regulation related to the conditions for awarding contracts for furnishing infusion drugs under the Medicare DMEPOS CBP.

  18. Medicaid program; health care-related taxes. Final rule.

    PubMed

    2009-06-30

    This rule finalizes our proposal to delay enforcement of certain clarifications regarding standards for determining hold harmless arrangements in the final rule entitled, "Medicaid Program; Health Care-Related Taxes" from the expiration of a Congressional moratorium on enforcement from July 1, 2009 to June 30, 2010.

  19. Pressure-volume Relationship in the Stress-echocardiography Laboratory: Does (Left Ventricular End-diastolic) Size Matter?

    PubMed

    Bombardini, Tonino; Mulieri, Louis A; Salvadori, Stefano; Costantino, Marco Fabio; Scali, Maria Chiara; Marzilli, Mario; Picano, Eugenio

    2017-02-01

    The variation between rest and peak stress end-systolic pressure-volume relation is an afterload-independent index of left ventricular contractility. Whether and to what extent it depends on end-diastolic volume remains unclear. The aim of this study was to assess the dependence of the delta rest-stress end-systolic pressure-volume relation on end-diastolic volume in patients with negative stress echo and all ranges of resting left ventricular function. We analyzed interpretable data obtained in 891 patients (593 men, age 63 ± 12 years) with ejection fraction 47% ± 12%: 338 were normal or near-normal or hypertensive; 229 patients had coronary artery disease; and 324 patients had ischemic or nonischemic dilated cardiomyopathy. They were studied with exercise (n = 172), dipyridamole (n = 482) or dobutamine (n = 237) stress echocardiography. The end-systolic pressure-volume relation was evaluated at rest and peak stress from raw measurement of systolic arterial pressure by cuff sphygmomanometer and end-systolic volume by biplane Simpson rule 2-dimensional echocardiography. Absolute values of delta rest-stress end-systolic pressure-volume relation were higher for exercise and dobutamine than for dipyridamole. In the overall population, an inverse relationship between end-systolic pressure-volume relation and end-diastolic volume was present at rest (r 2 = 0.69, P < .001) and peak stress (r 2 = 0.56, P < .001), but was absent if the delta rest-stress end-systolic pressure-volume relation was considered (r 2 = 0.13). Left ventricular end-diastolic volume does not affect the rest-stress changes in end-systolic pressure-volume relation in either normal or abnormal left ventricles during physical or pharmacological stress. Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  20. Organisational Rules in Schools: Teachers' Opinions about Functions of Rules, Rule-Following and Breaking Behaviours in Relation to Their Locus of Control

    ERIC Educational Resources Information Center

    Demirkasimoglu, Nihan; Aydin, Inayet; Erdogan, Cetin; Akin, Ugur

    2012-01-01

    The main aim of this research is to examine teachers' opinions about functions of school rules, reasons for rule-breaking and results of rule-breaking in relation to their locus of control, gender, age, seniority and branch. 350 public elementary school teachers in Ankara are included in the correlational survey model study. According to the…

  1. Double dissociation between rules and memory in music: an event-related potential study.

    PubMed

    Miranda, Robbin A; Ullman, Michael T

    2007-11-01

    Language and music share a number of characteristics. Crucially, both domains depend on both rules and memorized representations. Double dissociations between the neurocognition of rule-governed and memory-based knowledge have been found in language but not music. Here, the neural bases of both of these aspects of music were examined with an event-related potential (ERP) study of note violations in melodies. Rule-only violations consisted of out-of-key deviant notes that violated tonal harmony rules in novel (unfamiliar) melodies. Memory-only violations consisted of in-key deviant notes in familiar well-known melodies; these notes followed musical rules but deviated from the actual melodies. Finally, out-of-key notes in familiar well-known melodies constituted violations of both rules and memory. All three conditions were presented, within-subjects, to healthy young adults, half musicians and half non-musicians. The results revealed a double dissociation, independent of musical training, between rules and memory: both rule violation conditions, but not the memory-only violations, elicited an early, somewhat right-lateralized anterior-central negativity (ERAN), consistent with previous studies of rule violations in music, and analogous to the early left-lateralized anterior negativities elicited by rule violations in language. In contrast, both memory violation conditions, but not the rule-only violation, elicited a posterior negativity that might be characterized as an N400, an ERP component that depends, at least in part, on the processing of representations stored in long-term memory, both in language and in other domains. The results suggest that the neurocognitive rule/memory dissociation extends from language to music, further strengthening the similarities between the two domains.

  2. Double dissociation between rules and memory in music: An event-related potential study

    PubMed Central

    Miranda, Robbin A.; Ullman, Michael T.

    2007-01-01

    Language and music share a number of characteristics. Crucially, both domains depend on both rules and memorized representations. Double dissociations between the neurocognition of rule-governed and memory-based knowledge have been found in language but not music. Here, the neural bases of both of these aspects of music were examined with an event-related potential (ERP) study of note violations in melodies. Rule-only violations consisted of out-of-key deviant notes that violated tonal harmony rules in novel (unfamiliar) melodies. Memory-only violations consisted of in-key deviant notes in familiar well-known melodies; these notes followed musical rules but deviated from the actual melodies. Finally, out-of-key notes in familiar well-known melodies constituted violations of both rules and memory. All three conditions were presented, within-subjects, to healthy young adults, half musicians and half non-musicians. The results revealed a double dissociation, independent of musical training, between rules and memory: both rule violation conditions, but not the memory-only violations, elicited an early, somewhat right-lateralized anterior-central negativity (ERAN), consistent with previous studies of rule violations in music, and analogous to the early left-lateralized anterior negativities elicited by rule violations in language. In contrast, both memory violation conditions, but not the rule-only violation, elicited a posterior negativity that might be characterized as an N400, an ERP component that depends, at least in part, on the processing of representations stored in long-term memory, both in language and in other domains. The results suggest that the neurocognitive rule/memory dissociation extends from language to music, further strengthening the similarities between the two domains. PMID:17855126

  3. N400 elicited by incongruent ending words of Chinese idioms in healthy adults.

    PubMed

    Chen, Xing-shi; Tang, Yun-xiang; Xiao, Ze-ping; Wang, Ji-jun; Zhang, Ming-dao; Zhang, Zai-fu; Hu, Zhen-yu; Lou, Fei-ying; Chen, Chong; Zhang, Tian-hong

    2010-03-20

    Prior research about N400 has been mainly based on English stimuli, while the cognitive processing of Chinese characters is still unclear. The aim of the present study was to further investigate the semantic processing of Chinese idioms. Event related potentials (ERP) component N400 was elicited by 38 pairs of matching (congruent) and mismatching (incongruent) ended Chinese idioms: ending words with same phoneme but different shape and meaning (sPdSdM), with similar shape but different phoneme and meaning (sSdPdM), with same meaning but different phoneme and shape (sMdPdS), and words with different phoneme, shape and meaning (dPdSdM) and recorded by Guangzhou Runjie WJ-1 ERP instruments. In 62 right-handed healthy adults (age 19 - 50 years), N400 amplitudes and latencies were compared between matching and mismatching conditions at Fz, Cz and Pz. N400 showed a midline distribution and could be elicited in electrodes Fz, Cz and Pz. The mean values of N400 latencies and amplitudes were obtained for matching and mismatching ending words in healthy adults. Significant differences were found in N400 latencies and amplitudes in matching and mismatching ending-words idioms in healthy adults (P < 0.05). Compared with matching ending-words idioms, N400 latencies were prolonged and the amplitudes were increased in mismatching ones. N400s elicited by different types of stimuli showed different latencies and amplitudes, and longest N400 latency and largest N400 amplitude were elicited by ending-words with dPdSdM. No gender difference was found of N400 latency and amplitude in this study (P > 0.05). Compared with English stimuli, Chinese ideographic words could provide more flexible stimuli for N400 research in that the words have 3-dimension changes - phoneme, shape and meaning. Features of N400 elicited by matching and mismatching ending words in Chinese idioms are mainly determined by the meaning of the word. Some issues of N400 elicited by Chinese characters deserve further

  4. Jahn-Teller effect versus Hund's rule coupling in C60N-

    NASA Astrophysics Data System (ADS)

    Wehrli, S.; Sigrist, M.

    2007-09-01

    We propose variational states for the ground state and the low-energy collective rotator excitations in negatively charged C60N- ions (N=1,…,5) . The approach includes the linear electron-phonon coupling and the Coulomb interaction on the same level. The electron-phonon coupling is treated within the effective mode approximation which yields the linear t1u⊗Hg Jahn-Teller problem whereas the Coulomb interaction gives rise to Hund’s rule coupling for N=2,3,4 . The Hamiltonian has accidental SO(3) symmetry which allows an elegant formulation in terms of angular momenta. Trial states are constructed from coherent states and using projection operators onto angular momentum subspaces which results in good variational states for the complete parameter range. The evaluation of the corresponding energies is to a large extent analytical. We use the approach for a detailed analysis of the competition between Jahn-Teller effect and Hund’s rule coupling, which determines the spin state for N=2,3,4 . We calculate the low-spin-high-spin gap for N=2,3,4 as a function of the Hund’s rule coupling constant J . We find that the experimentally measured gaps suggest a coupling constant in the range J=60-80meV . Using a finite value for J , we recalculate the ground state energies of the C60N- ions and find that the Jahn-Teller energy gain is partly counterbalanced by the Hund’s rule coupling. In particular, the ground state energies for N=2,3,4 are almost equal.

  5. Medicare Program; End-Stage Renal Disease Prospective Payment System, Payment for Renal Dialysis Services Furnished to Individuals With Acute Kidney Injury, and End-Stage Renal Disease Quality Incentive Program. Final rule.

    PubMed

    2017-11-01

    This rule updates and makes revisions to the end-stage renal disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2018. It also updates the payment rate for renal dialysis services furnished by an ESRD facility to individuals with acute kidney injury (AKI). This rule also sets forth requirements for the ESRD Quality Incentive Program (QIP), including for payment years (PYs) 2019 through 2021.

  6. End-to-end modeling as part of an integrated research program in the Bering Sea

    NASA Astrophysics Data System (ADS)

    Punt, André E.; Ortiz, Ivonne; Aydin, Kerim Y.; Hunt, George L.; Wiese, Francis K.

    2016-12-01

    Traditionally, the advice provided to fishery managers has focused on the trade-offs between short- and long-term yields, and between future resource size and expected future catches. The harvest control rules that are used to provide management advice consequently relate catches to stock biomass levels expressed relative to reference biomass levels. There are, however, additional trade-offs. Ecosystem-based fisheries management (EBFM) aims to consider fish and fisheries in their ecological context, taking into account physical, biological, economic, and social factors. However, making EBFM operational remains challenging. It is generally recognized that end-to-end modeling should be a key part of implementing EBFM, along with harvest control rules that use information in addition to estimates of stock biomass to provide recommendations for management actions. Here we outline the process for selecting among alternative management strategies in an ecosystem context and summarize a Field-integrated End-To-End modeling program, or FETE, intended to implement this process as part of the Bering Sea Project. A key aspect of this project was that, from the start, the FETE included a management strategy evaluation component to compare management strategies. Effective use of end-to-end modeling requires that the models developed for a system are indeed integrated across climate drivers, lower trophic levels, fish population dynamics, and fisheries and their management. We summarize the steps taken by the program managers to promote integration of modeling efforts by multiple investigators and highlight the lessons learned during the project that can be used to guide future use and design of end-to-end models.

  7. Age-Related Brain Activation Changes during Rule Repetition in Word-Matching.

    PubMed

    Methqal, Ikram; Pinsard, Basile; Amiri, Mahnoush; Wilson, Maximiliano A; Monchi, Oury; Provost, Jean-Sebastien; Joanette, Yves

    2017-01-01

    Objective: The purpose of this study was to explore the age-related brain activation changes during a word-matching semantic-category-based task, which required either repeating or changing a semantic rule to be applied. In order to do so, a word-semantic rule-based task was adapted from the Wisconsin Sorting Card Test, involving the repeated feedback-driven selection of given pairs of words based on semantic category-based criteria. Method: Forty healthy adults (20 younger and 20 older) performed a word-matching task while undergoing a fMRI scan in which they were required to pair a target word with another word from a group of three words. The required pairing is based on three word-pair semantic rules which correspond to different levels of semantic control demands: functional relatedness, moderately typical-relatedness (which were considered as low control demands), and atypical-relatedness (high control demands). The sorting period consisted of a continuous execution of the same sorting rule and an inferred trial-by-trial feedback was given. Results: Behavioral performance revealed increases in response times and decreases of correct responses according to the level of semantic control demands (functional vs. typical vs. atypical) for both age groups (younger and older) reflecting graded differences in the repetition of the application of a given semantic rule. Neuroimaging findings of significant brain activation showed two main results: (1) Greater task-related activation changes for the repetition of the application of atypical rules relative to typical and functional rules, and (2) Changes (older > younger) in the inferior prefrontal regions for functional rules and more extensive and bilateral activations for typical and atypical rules. Regarding the inter-semantic rules comparison, only task-related activation differences were observed for functional > typical (e.g., inferior parietal and temporal regions bilaterally) and atypical > typical (e

  8. Spectral sum rules for confining large-N theories

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cherman, Aleksey; McGady, David A.; Yamazaki, Masahito

    2016-06-17

    We consider asymptotically-free four-dimensional large-$N$ gauge theories with massive fermionic and bosonic adjoint matter fields, compactified on squashed three-spheres, and examine their regularized large-$N$ confined-phase spectral sums. The analysis is done in the limit of vanishing ’t Hooft coupling, which is justified by taking the size of the compactification manifold to be small compared to the inverse strong scale Λ ₋1. We find our results motivate us to conjecture some universal spectral sum rules for these large $N$ gauge theories.

  9. 78 FR 6273 - Rules Relating to Additional Medicare Tax

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Parts 1 and 31 [REG-130074-11] RIN 1545-BK54 Rules Relating to Additional Medicare Tax Correction In proposed rule document 2012-29237, appearing on pages 72268- 72277 in the issue of Wednesday, December 5, 2012, make the following correction...

  10. A path planning method for robot end effector motion using the curvature theory of the ruled surfaces

    NASA Astrophysics Data System (ADS)

    Güler, Fatma; Kasap, Emin

    Using the curvature theory for the ruled surfaces a technique for robot trajectory planning is presented. This technique ensures the calculation of robot’s next path. The positional variation of the Tool Center Point (TCP), linear velocity, angular velocity are required in the work area of the robot. In some circumstances, it may not be physically achievable and a re-computation of the robot trajectory might be necessary. This technique is suitable for re-computation of the robot trajectory. We obtain different robot trajectories which change depending on the darboux angle function and define trajectory ruled surface family with a common trajectory curve with the rotation trihedron. Also, the motion of robot end effector is illustrated with examples.

  11. Widespread neural oscillations in the delta band dissociate rule convergence from rule divergence during creative idea generation.

    PubMed

    Boot, Nathalie; Baas, Matthijs; Mühlfeld, Elisabeth; de Dreu, Carsten K W; van Gaal, Simon

    2017-09-01

    Critical to creative cognition and performance is both the generation of multiple alternative solutions in response to open-ended problems (divergent thinking) and a series of cognitive operations that converges on the correct or best possible answer (convergent thinking). Although the neural underpinnings of divergent and convergent thinking are still poorly understood, several electroencephalography (EEG) studies point to differences in alpha-band oscillations between these thinking modes. We reason that, because most previous studies employed typical block designs, these pioneering findings may mainly reflect the more sustained aspects of creative processes that extend over longer time periods, and that still much is unknown about the faster-acting neural mechanisms that dissociate divergent from convergent thinking during idea generation. To this end, we developed a new event-related paradigm, in which we measured participants' tendency to implicitly follow a rule set by examples, versus breaking that rule, during the generation of novel names for specific categories (e.g., pasta, planets). This approach allowed us to compare the oscillatory dynamics of rule convergent and rule divergent idea generation and at the same time enabled us to measure spontaneous switching between these thinking modes on a trial-to-trial basis. We found that, relative to more systematic, rule convergent thinking, rule divergent thinking was associated with widespread decreases in delta band activity. Therefore, this study contributes to advancing our understanding of the neural underpinnings of creativity by addressing some methodological challenges that neuroscientific creativity research faces. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. 26 CFR 301.6501(n)-1 - Special rules for chapter 42 and similar taxes.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Special rules for chapter 42 and similar taxes. 301.6501(n)-1 Section 301.6501(n)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Assessment and Collection § 301.6501(n)-1 Special rules for chapter 42 and similar taxes. (a) Return filed by...

  13. 26 CFR 301.6501(n)-1 - Special rules for chapter 42 and similar taxes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Special rules for chapter 42 and similar taxes. 301.6501(n)-1 Section 301.6501(n)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Assessment and Collection § 301.6501(n)-1 Special rules for chapter 42 and similar taxes. (a) Return filed by...

  14. 26 CFR 48.4223-1 - Special rules relating to further manufacture.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 16 2010-04-01 2010-04-01 true Special rules relating to further manufacture.... § 48.4223-1 Special rules relating to further manufacture. (a) Purchasing manufacturer to be treated as... resold tax free under section 4221(a)(1) of the Code for use by it in further manufacture shall be...

  15. Integrands for QCD rational terms and {N} = {4} SYM from massive CSW rules

    NASA Astrophysics Data System (ADS)

    Elvang, Henriette; Freedman, Daniel Z.; Kiermaier, Michael

    2012-06-01

    We use massive CSW rules to derive explicit compact expressions for integrands of rational terms in QCD with any number of external legs. Specifically, we present all- n integrands for the one-loop all-plus and one-minus gluon amplitudes in QCD. We extract the finite part of spurious external-bubble contributions systematically; this is crucial for the application of integrand-level CSW rules in theories without supersymmetry. Our approach yields integrands that are independent of the choice of CSW reference spinor even before integration. Furthermore, we present a recursive derivation of the recently proposed massive CSW-style vertex expansion for massive tree amplitudes and loop integrands on the Coulomb-branch of {N} = {4} SYM. The derivation requires a careful study of boundary terms in all-line shift recursion relations, and provides a rigorous (albeit indirect) proof of the recently proposed construction of massive amplitudes from soft-limits of massless on-shell amplitudes. We show that the massive vertex expansion manifestly preserves all holomorphic and half of the anti-holomorphic supercharges, diagram-by-diagram, even off-shell.

  16. N-cadherin expression in palisade nerve endings of rat vellus hairs.

    PubMed

    Kaidoh, Toshiyuki; Inoué, Takao

    2008-02-01

    Palisade nerve endings (PNs) are mechanoreceptors around vellus hairs of mammals. Each lanceolate nerve ending (LN) of the PN is characterized by a sensory nerve ending symmetrically sandwiched by two processes of type II terminal Schwann cells (tSCIIs). However, the molecular mechanisms underlying the structural organization of the PN are poorly understood. Electron microscopy showed that adherens junctions appeared to adhere to the sensory nerve ending and tSCII processes, so we examined the location of the N-cadherin adhesion system in PNs of rat vellus hairs by using immunoelectron microscopy. N-cadherin localized near both ends of the cell boundary between sensory nerve ending and tSCII processes, which corresponded to the sites of adherens junctions. We further found cadherin-associated proteins, alpha- and beta-catenins, at the linings of adherens junctions. Three-dimensional reconstruction of immunoelectron microscopic serial thin sections showed four linear arrays of N-cadherin arranged longitudinally along the LN beneath the four longitudinal borders of two tSCII processes. In contrast, sensory nerve fibers just proximal to the LNs formed common unmyelinated nerve fibers, in which N-cadherin was located mainly at the mesaxon of type I terminal Schwann cells (tSCIs). These results suggest that the four linear arrays of N-cadherin-mediated junctions adhere the sensory nerve ending and tSCII processes side by side to form the characteristic structure of the LN, and the structural differences between the LNs and the proximal unmyelinated nerve fibers possibly are due to the difference in the pattern of N-cadherin expression between sensory nerve endings and tSCII or tSCI processes. (c) 2007 Wiley-Liss, Inc.

  17. 36 CFR 902.52 - Records related solely to internal personnel rules and practices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Corporation Records § 902.52 Records related solely to internal personnel rules and practices. (a) Records... hiring, training, promotion, demotion, and discharge of employees, and management plans, records, or... protection of any record related to internal personnel rules and practices dealing with the relations between...

  18. 36 CFR 902.52 - Records related solely to internal personnel rules and practices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Corporation Records § 902.52 Records related solely to internal personnel rules and practices. (a) Records... hiring, training, promotion, demotion, and discharge of employees, and management plans, records, or... protection of any record related to internal personnel rules and practices dealing with the relations between...

  19. 36 CFR 902.52 - Records related solely to internal personnel rules and practices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Corporation Records § 902.52 Records related solely to internal personnel rules and practices. (a) Records... hiring, training, promotion, demotion, and discharge of employees, and management plans, records, or... protection of any record related to internal personnel rules and practices dealing with the relations between...

  20. 36 CFR 902.52 - Records related solely to internal personnel rules and practices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Corporation Records § 902.52 Records related solely to internal personnel rules and practices. (a) Records... hiring, training, promotion, demotion, and discharge of employees, and management plans, records, or... protection of any record related to internal personnel rules and practices dealing with the relations between...

  1. C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.

    PubMed

    Lin, Hsiu-Chuan; Yeh, Chi-Wei; Chen, Yen-Fu; Lee, Ting-Ting; Hsieh, Pei-Yun; Rusnac, Domnita V; Lin, Sung-Ya; Elledge, Stephen J; Zheng, Ning; Yen, Hsueh-Chi S

    2018-05-17

    The proteolysis-assisted protein quality control system guards the proteome from potentially detrimental aberrant proteins. How miscellaneous defective proteins are specifically eliminated and which molecular characteristics direct them for removal are fundamental questions. We reveal a mechanism, DesCEND (destruction via C-end degrons), by which CRL2 ubiquitin ligase uses interchangeable substrate receptors to recognize the unusual C termini of abnormal proteins (i.e., C-end degrons). C-end degrons are mostly less than ten residues in length and comprise a few indispensable residues along with some rather degenerate ones. The C-terminal end position is essential for C-end degron function. Truncated selenoproteins generated by translation errors and the USP1 N-terminal fragment from post-translational cleavage are eliminated by DesCEND. DesCEND also targets full-length proteins with naturally occurring C-end degrons. The C-end degron in DesCEND echoes the N-end degron in the N-end rule pathway, highlighting the dominance of protein "ends" as indicators for protein elimination. Copyright © 2018 Elsevier Inc. All rights reserved.

  2. Exploration of SWRL Rule Bases through Visualization, Paraphrasing, and Categorization of Rules

    NASA Astrophysics Data System (ADS)

    Hassanpour, Saeed; O'Connor, Martin J.; Das, Amar K.

    Rule bases are increasingly being used as repositories of knowledge content on the Semantic Web. As the size and complexity of these rule bases increases, developers and end users need methods of rule abstraction to facilitate rule management. In this paper, we describe a rule abstraction method for Semantic Web Rule Language (SWRL) rules that is based on lexical analysis and a set of heuristics. Our method results in a tree data structure that we exploit in creating techniques to visualize, paraphrase, and categorize SWRL rules. We evaluate our approach by applying it to several biomedical ontologies that contain SWRL rules, and show how the results reveal rule patterns within the rule base. We have implemented our method as a plug-in tool for Protégé-OWL, the most widely used ontology modeling software for the Semantic Web. Our tool can allow users to rapidly explore content and patterns in SWRL rule bases, enabling their acquisition and management.

  3. 36 CFR § 902.52 - Records related solely to internal personnel rules and practices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Corporation Records § 902.52 Records related solely to internal personnel rules and practices. (a) Records... hiring, training, promotion, demotion, and discharge of employees, and management plans, records, or... protection of any record related to internal personnel rules and practices dealing with the relations between...

  4. 78 FR 6272 - Rules Relating to Additional Medicare Tax; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... Rules Relating to Additional Medicare Tax; Correction AGENCY: Internal Revenue Service (IRS), Treasury... regulations are relating to Additional Hospital Insurance Tax on income above threshold amounts (``Additional Medicare Tax''), as added by the Affordable Care Act. Specifically, these proposed regulations provide...

  5. 16 CFR 456.5 - Rules applicable to prescriptions for contact lenses and related issues.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... contact lenses and related issues. 456.5 Section 456.5 Commercial Practices FEDERAL TRADE COMMISSION TRADE... contact lenses and related issues. Rules applicable to prescriptions for contact lenses and related issues may be found at 16 CFR part 315 (Contact Lens Rule). [69 FR 40511, July 2, 2004] ...

  6. Wrapping rules (in) string theory

    NASA Astrophysics Data System (ADS)

    Bergshoeff, Eric A.; Riccioni, Fabio

    2018-01-01

    In this paper we show that the number of all 1/2-BPS branes in string theory compactified on a torus can be derived by universal wrapping rules whose formulation we present. These rules even apply to branes in less than ten dimensions whose ten-dimensional origin is an exotic brane. In that case the wrapping rules contain an additional combinatorial factor that is related to the highest dimension in which the ten-dimensional exotic brane, after compactification, can be realized as a standard brane. We show that the wrapping rules also apply to cases with less supersymmetry. As a specific example, we discuss the compactification of IIA/IIB string theory on ( T 4/ ℤ 2) × T n .

  7. 76 FR 77699 - Special Procedural Rules Governing Periods When the National Labor Relations Board Lacks a Quorum...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... NATIONAL LABOR RELATIONS BOARD 29 CFR Part 102 Special Procedural Rules Governing Periods When the National Labor Relations Board Lacks a Quorum of Members AGENCY: National Labor Relations Board. ACTION: Final rule. SUMMARY: The National Labor Relations Board is revising its rules governing the...

  8. Soft drink consumption in adolescence: associations with food-related lifestyles and family rules in Belgium Flanders and the Veneto Region of Italy.

    PubMed

    Verzeletti, Chiara; Maes, Lea; Santinello, Massimo; Vereecken, Carine A

    2010-06-01

    The number of studies among adolescents that focus on several lifestyle behaviours and family rules as determinant of soft drink consumption are limited. The aim of this study is to investigate the associations between daily soft drink consumption, food-related lifestyles and family rules in adolescence. The data are part of the Health Behavior in School-aged Children (HBSC) cross-sectional survey. Adolescents between 11 and 16 years of age were included, resulting in a final sample of 14 407 adolescents representative of Belgium Flanders (N = 7904) and the Veneto Region of Italy (N = 6503). Binary logistic regression was used to test the association between soft drink consumption and food-related lifestyle (breakfast habits, family meals, snacking, meals in fast food restaurants and television viewing) and family rules (restriction and obligation rules) by region and gender. Each independent variable is significantly associated with daily soft drink consumption, despite some sub-groups exceptions. When we entered all the variables into the same statistical model, the positive association with daily soft drink consumption remained significant for frequent meals in fast food restaurants, television variables and low restriction rules. Breakfast during weekdays, evening meal with parents and obligation rules remained significant only in specific sub-groups and not the entire sample. Finally, the association with breakfast with parents and during the weekend disappeared. These findings suggest that considering gender and cultural differences, involving parents and limiting adolescents' exposure to television would increase the effectiveness of interventions aimed to reduce soft drink consumption in adolescence.

  9. 26 CFR 1.263A-14 - Rules for related persons.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....263A-14 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Not Deductible § 1.263A-14 Rules for related persons. Taxpayers must account for average excess expenditures allocated to related persons under applicable...

  10. 26 CFR 1.263A-14 - Rules for related persons.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....263A-14 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Items Not Deductible § 1.263A-14 Rules for related persons. Taxpayers must account for average excess expenditures allocated to related persons under applicable administrative...

  11. 78 FR 71468 - Rules Relating to Additional Medicare Tax

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-29

    ... Rules Relating to Additional Medicare Tax AGENCY: Internal Revenue Service (IRS), Treasury. ACTION... Insurance Tax on income above threshold amounts (``Additional Medicare Tax''), as added by the Affordable... to the implementation of Additional Medicare Tax, including the requirement to withhold Additional...

  12. The N-degradome of Escherichia coli

    PubMed Central

    Humbard, Matthew A.; Surkov, Serhiy; De Donatis, Gian Marco; Jenkins, Lisa M.; Maurizi, Michael R.

    2013-01-01

    The N-end rule is a conserved mechanism found in Gram-negative bacteria and eukaryotes for marking proteins to be degraded by ATP-dependent proteases. Specific N-terminal amino acids (N-degrons) are sufficient to target a protein to the degradation machinery. In Escherichia coli, the adaptor ClpS binds an N-degron and delivers the protein to ClpAP for degradation. As ClpS recognizes N-terminal Phe, Trp, Tyr, and Leu, which are not found at the N terminus of proteins translated and processed by the canonical pathway, proteins must be post-translationally modified to expose an N-degron. One modification is catalyzed by Aat, an enzyme that adds leucine or phenylalanine to proteins with N-terminal lysine or arginine; however, such proteins are also not generated by the canonical protein synthesis pathway. Thus, the mechanisms producing N-degrons in proteins and the frequency of their occurrence largely remain a mystery. To address these issues, we used a ClpS affinity column to isolate interacting proteins from E. coli cell lysates under non-denaturing conditions. We identified more than 100 proteins that differentially bound to a column charged with wild-type ClpS and eluted with a peptide bearing an N-degron. Thirty-two of 37 determined N-terminal peptides had N-degrons. Most of the proteins were N-terminally truncated by endoproteases or exopeptidases, and many were further modified by Aat. The identities of the proteins point to possible physiological roles for the N-end rule in cell division, translation, transcription, and DNA replication and reveal widespread proteolytic processing of cellular proteins to generate N-end rule substrates. PMID:23960079

  13. The End of the HIPAA Privacy Rule? Currents in Contemporary Bioethics.

    PubMed

    Rothstein, Mark A

    2016-06-01

    The HIPAA Privacy Rule is notoriously weak because of its incomplete coverage, numerous exclusions and exemptions, and limited rights for individuals. The three areas in which it provides the most protection are fundraising, marketing, and research. Provisions of the 21st Century Cures Act, pending in Congress, and the Notice of Proposed Rulemaking to amend the federal research regulations (Common Rule), awaiting final regulatory action, would weaken the privacy protections for research. If these measures are adopted, the HIPAA Privacy Rule would have so little value that it might not be worth the aggravation and burden. © 2016 American Society of Law, Medicine & Ethics.

  14. QCD Sum Rules and Models for Generalized Parton Distributions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anatoly Radyushkin

    2004-10-01

    I use QCD sum rule ideas to construct models for generalized parton distributions. To this end, the perturbative parts of QCD sum rules for the pion and nucleon electromagnetic form factors are interpreted in terms of GPDs and two models are discussed. One of them takes the double Borel transform at adjusted value of the Borel parameter as a model for nonforward parton densities, and another is based on the local duality relation. Possible ways of improving these Ansaetze are briefly discussed.

  15. 17 CFR 239.14 - Form N-2 for closed end management investment companies registered on Form N-8A.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... management investment companies registered on Form N-8A. 239.14 Section 239.14 Commodity and Securities... Registration Statements § 239.14 Form N-2 for closed end management investment companies registered on Form N... closed end management investment companies registered under the Investment Company Act of 1940 on form N...

  16. 42 CFR 433.57 - General rules regarding revenues from provider-related donations and health care-related taxes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-related donations and health care-related taxes. 433.57 Section 433.57 Public Health CENTERS FOR MEDICARE... rules regarding revenues from provider-related donations and health care-related taxes. Effective... FFP, funds from provider-related donations and revenues generated by health care-related taxes...

  17. 42 CFR 433.57 - General rules regarding revenues from provider-related donations and health care-related taxes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-related donations and health care-related taxes. 433.57 Section 433.57 Public Health CENTERS FOR MEDICARE... rules regarding revenues from provider-related donations and health care-related taxes. Effective... FFP, funds from provider-related donations and revenues generated by health care-related taxes...

  18. 42 CFR 433.57 - General rules regarding revenues from provider-related donations and health care-related taxes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-related donations and health care-related taxes. 433.57 Section 433.57 Public Health CENTERS FOR MEDICARE... rules regarding revenues from provider-related donations and health care-related taxes. Effective... FFP, funds from provider-related donations and revenues generated by health care-related taxes...

  19. 42 CFR 433.57 - General rules regarding revenues from provider-related donations and health care-related taxes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...-related donations and health care-related taxes. 433.57 Section 433.57 Public Health CENTERS FOR MEDICARE... rules regarding revenues from provider-related donations and health care-related taxes. Effective... FFP, funds from provider-related donations and revenues generated by health care-related taxes...

  20. 42 CFR 433.57 - General rules regarding revenues from provider-related donations and health care-related taxes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-related donations and health care-related taxes. 433.57 Section 433.57 Public Health CENTERS FOR MEDICARE... rules regarding revenues from provider-related donations and health care-related taxes. Effective... FFP, funds from provider-related donations and revenues generated by health care-related taxes...

  1. 47 CFR 64.609 - Enforcement of related customer premises equipment rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Enforcement of related customer premises... Relay Services and Related Customer Premises Equipment for Persons With Disabilities § 64.609 Enforcement of related customer premises equipment rules. Enforcement of §§ 64.607 and 64.608 is delegated to...

  2. 17 CFR 239.15 - Form N-1 for open-end management investment companies registered on Form N-8A.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... management investment companies registered on Form N-8A. 239.15 Section 239.15 Commodity and Securities... Registration Statements § 239.15 Form N-1 for open-end management investment companies registered on Form N-8A...-end management investment companies that are separate accounts of insurance companies as defined by...

  3. Cue response dissociates inhibitory processes: task identity information is related to backward inhibition but not to competitor rule suppression.

    PubMed

    Regev, Shirley; Meiran, Nachshon

    2017-01-01

    In task switching, a conflict between competing task-sets is resolved by inhibiting the interfering task-set. Recent models have proposed a framework of the task-set as composed of two hierarchical components: abstract task identity (e.g., respond to quantity) and more concrete task rules (e.g., category-response rules mapping the categories "one" and "three" to the left and right keys, respectively). The present study explored whether task-set inhibition is the outcome of a general control process or whether it reflects multiple inhibitory processes, each targeting a different component of the competing task-set. To this end, two effects of task-set inhibition were examined: backward inhibition (BI), reflecting the suppression of a just-performed task-set that is no longer relevant; and, competitor rule suppression (CRS), reflecting the suppression of an irrelevant task-set that generates a response conflict. In two task switching experiments, each involving three tasks, we asked participants to make two responses: a cue response, indicating the identity of the relevant task (e.g., "Color"), and a target response requiring the implementation of the task rule (e.g., "Red"). The results demonstrate that BI, but not CRS, appears in cue responses, and thus, suggests that BI reflects inhibition that influences representations related to abstract task identity, rather than (just) competing responses or response rules. These results support a dissociation between inhibitory processes in task switching. The current findings also provide further evidence for a multi-component conceptualization of task-set and task-set inhibition.

  4. 78 FR 72155 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ...This rule updates and makes revisions to the End-Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2014. This rule also sets forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2016 and beyond. In addition, this rule clarifies the grandfathering provision related to the 3-year minimum lifetime requirement (MLR) for Durable Medical Equipment (DME), and provides clarification of the definition of routinely purchased DME. This rule also implements budget-neutral fee schedules for splints and casts, and intraocular lenses (IOLs) inserted in a physician's office. Finally, this rule makes a few technical amendments and corrections to existing regulations related to payment for durable medical equipment, prosthetics, orthotics, and supplies (DMEPOS) items and services.

  5. Thaw; New Rules to End the Cable TV Freeze.

    ERIC Educational Resources Information Center

    National Cable Television Association, Inc., Washington, DC.

    The report summarizes the Federal Communications Commission's (FCC) rulemaking of February 3, 1972 for cable television (CATV) concerning what channels must be carried in certain categories of broadcast markets, use of non-broadcast channels, technical standards, and federal/state/local regulatory relationships. The report highlights the rule that…

  6. 26 CFR 1.818-8 - Special rules relating to consolidated returns and certain capital losses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Special rules relating to consolidated returns... Special rules relating to consolidated returns and certain capital losses. Section 818(g) provides that, in the case of a life insurance company filing or required to file a consolidated return under...

  7. Implementation of artificial intelligence rules in a data base management system

    NASA Technical Reports Server (NTRS)

    Feyock, S.

    1986-01-01

    The intelligent front end prototype was transformed into a RIM-integrated system. A RIM-based expert system was written which demonstrated the developed capability. The use of rules to produce extensibility of the intelligent front end, including the concept of demons and rule manipulation rules were investigated. Innovative approaches such as syntax programming were to be considered.

  8. Conformance Testing: Measurement Decision Rules

    NASA Technical Reports Server (NTRS)

    Mimbs, Scott M.

    2010-01-01

    The goal of a Quality Management System (QMS) as specified in ISO 9001 and AS9100 is to provide assurance to the customer that end products meet specifications. Measuring devices, often called measuring and test equipment (MTE), are used to provide the evidence of product conformity to specified requirements. Unfortunately, processes that employ MTE can become a weak link to the overall QMS if proper attention is not given to the measurement process design, capability, and implementation. Documented "decision rules" establish the requirements to ensure measurement processes provide the measurement data that supports the needs of the QMS. Measurement data are used to make the decisions that impact all areas of technology. Whether measurements support research, design, production, or maintenance, ensuring the data supports the decision is crucial. Measurement data quality can be critical to the resulting consequences of measurement-based decisions. Historically, most industries required simplistic, one-size-fits-all decision rules for measurements. One-size-fits-all rules in some cases are not rigorous enough to provide adequate measurement results, while in other cases are overly conservative and too costly to implement. Ideally, decision rules should be rigorous enough to match the criticality of the parameter being measured, while being flexible enough to be cost effective. The goal of a decision rule is to ensure that measurement processes provide data with a sufficient level of quality to support the decisions being made - no more, no less. This paper discusses the basic concepts of providing measurement-based evidence that end products meet specifications. Although relevant to all measurement-based conformance tests, the target audience is the MTE end-user, which is anyone using MTE other than calibration service providers. Topics include measurement fundamentals, the associated decision risks, verifying conformance to specifications, and basic measurement

  9. The diversity of the N2O reducers matters for the N2O:N2 denitrification end-product ratio across an annual and a perennial cropping system.

    PubMed

    Domeignoz-Horta, Luiz A; Spor, Aymé; Bru, David; Breuil, Marie-Christine; Bizouard, Florian; Léonard, Joël; Philippot, Laurent

    2015-01-01

    Agriculture is the main source of terrestrial emissions of N2O, a potent greenhouse gas and the main cause of ozone layer depletion. The reduction of N2O into N2 by microorganisms carrying the nitrous oxide reductase gene (nosZ) is the only biological process known to eliminate this greenhouse gas. Recent studies showed that a previously unknown clade of N2O-reducers was related to the capacity of the soil to act as an N2O sink, opening the way for new strategies to mitigate emissions. Here, we investigated whether the agricultural practices could differently influence the two N2O reducer clades with consequences for denitrification end-products. The abundance of N2O-reducers and producers was quantified by real-time PCR, and the diversity of both nosZ clades was determined by 454 pyrosequencing. Potential N2O production and potential denitrification activity were used to calculate the denitrification gaseous end-product ratio. Overall, the results showed limited differences between management practices but there were significant differences between cropping systems in both the abundance and structure of the nosZII community, as well as in the [rN2O/r(N2O+N2)] ratio. More limited differences were observed in the nosZI community, suggesting that the newly identified nosZII clade is more sensitive than nosZI to environmental changes. Potential denitrification activity and potential N2O production were explained mainly by the soil properties while the diversity of the nosZII clade on its own explained 26% of the denitrification end-product ratio, which highlights the importance of understanding the ecology of this newly identified clade of N2O reducers for mitigation strategies.

  10. 78 FR 40835 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ...This rule proposes to update and make revisions to the End- Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2014. This rule also proposes to set forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2016 and beyond. In addition, this rule proposes to clarify the grandfathering provision related to the 3-year minimum lifetime requirement (MLR) for Durable Medical Equipment (DME). In addition, it provides clarification of the definition of routinely purchased DME. This rule also proposes the implementation of budget- neutral fee schedules for splints and casts, and intraocular lenses (IOLs) inserted in a physician's office. Finally, this rule would make a few technical amendments and corrections to existing regulations related to payment for DMEPOS items and services.

  11. 78 FR 70370 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... open-end investment company that issues Investment Company Units, listed and traded on the Exchange...-based, fixed income exchange-traded funds (``ETFs'') contained in NYSE Arca Equities Rule 5.2(j)(3... and traded in the U.S. on registered exchanges. While the Fund may invest in inverse ETFs, the Fund...

  12. Gender-Based Behavioral Analysis for End-User Development and the "RULES" Attributes

    ERIC Educational Resources Information Center

    Tzafilkou, Katerina; Protogeros, Nicolaos; Karagiannidis, Charalampos; Koumpis, Adamantios

    2017-01-01

    This paper addresses the role of gender in End-User Development (EUD) environments and examines whether there are gender differences in performance and in correlations between performance and a set of behavioral attributes. Based on a review of the most prominent EUD-related behavioral Human Computer Interaction (HCI) theories, and the influence…

  13. Defining Alcohol-Specific Rules Among Parents of Older Adolescents: Moving Beyond No Tolerance.

    PubMed

    Bourdeau, Beth; Miller, Brenda; Vanya, Magdalena; Duke, Michael; Ames, Genevieve

    2012-01-01

    Parental beliefs and rules regarding their teen's use of alcohol influence teen decisions regarding alcohol use. However, measurement of parental rules regarding adolescent alcohol use has not been thoroughly studied. This study used qualitative interviews with 174 parents of older teens from 100 families. From open-ended questions, themes emerged that describe explicit rules tied to circumscribed use, no tolerance, and "call me." There was some inconsistency in explicit rules with and between parents. Responses also generated themes relating to implicit rules such as expectations and preferences. Parents described their methods of communicating their position via conversational methods, role modeling their own behavior, teaching socially appropriate use of alcohol by offering their teen alcohol, and monitoring their teens' social activities. Findings indicate that alcohol rules are not adequately captured by current assessment measures.

  14. PIV Measurements of Gas Flow Fields from Burning End

    NASA Astrophysics Data System (ADS)

    Huang, Yifei; Wu, Junzhang; Zeng, Jingsong; Tang, Darong; Du, Liang

    2017-12-01

    To study the influence of cigarette gas on the environment, it is necessary to know the cigarette gas flow fields from burning end. By using PIV technique, in order to reveal velocity characteristics of gas flow fields, the velocities of cigarette gas flow fields was analyzed with different stepping motor frequencies corresponding to suction pressures, and the trend of velocity has been given with image fitting. The results shows that the velocities of the burning end increased with suction pressures; Between velocities of the burning end and suction pressures, the relations present polynomial rule; The cigarette gas diffusion in combustion process is faster than in the smoldering process.

  15. 29 CFR 2590.701-4 - Rules relating to creditable coverage.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 2590.701-4 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR GROUP HEALTH PLANS RULES AND REGULATIONS FOR GROUP HEALTH PLANS Health Coverage... I of the Act, and without regard to whether the coverage is offered in the group market, the...

  16. 29 CFR 2590.701-4 - Rules relating to creditable coverage.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 2590.701-4 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR GROUP HEALTH PLANS RULES AND REGULATIONS FOR GROUP HEALTH PLANS Health Coverage... I of the Act, and without regard to whether the coverage is offered in the group market, the...

  17. 29 CFR 2590.701-4 - Rules relating to creditable coverage.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 2590.701-4 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR GROUP HEALTH PLANS RULES AND REGULATIONS FOR GROUP HEALTH PLANS Health Coverage... I of the Act, and without regard to whether the coverage is offered in the group market, the...

  18. Relatives in end-of-life care--part 2: a theory for enabling safety.

    PubMed

    Ohlén, Joakim; Andershed, Birgitta; Berg, Christina; Frid, Ingvar; Palm, Carl-Axel; Ternestedt, Britt-Marie; Segesten, Kerstin

    2007-02-01

    To develop a goal-oriented praxis theory for enabling safety for relatives when an adult or older patient is close to end-of-life. This is the second part of a project focusing on the situation and needs of relatives in end-of-life care. Our interpretation of the existing corpus of knowledge pertaining to the needs of close relatives in this situation showed the significance of relatives' need for safety. The theory was developed step-by-step, through triangulation of critical review of empirical research in the field, our own clinical experiences from end-of-life care, renewed literature searches and theoretical reasoning. The foundation for the theory is taken from the ethical intention of the philosopher Paul Ricoeur. From this, the theory focuses on relatives in the context of end-of-life care with the goal of enabling safety. This is proposed by four aphorisms functioning as safety enablers and these are directed towards the professional's approach and attitude, the relative's concern for the patient, the specific situation for the relative and the patient's end-of-life period as a period in the life of the relative. Implications for end-of-life practice are considered and include aspects for promotion of just institutions in end-of-life care, the significance of negotiated partnership in end-of-life care, enabling safety for relatives living in existential and practical uncertainty in connection with end-of-life care and diversity of relatives' preferences as they live through this particular period.

  19. New QCD sum rules based on canonical commutation relations

    NASA Astrophysics Data System (ADS)

    Hayata, Tomoya

    2012-04-01

    New derivation of QCD sum rules by canonical commutators is developed. It is the simple and straightforward generalization of Thomas-Reiche-Kuhn sum rule on the basis of Kugo-Ojima operator formalism of a non-abelian gauge theory and a suitable subtraction of UV divergences. By applying the method to the vector and axial vector current in QCD, the exact Weinberg’s sum rules are examined. Vector current sum rules and new fractional power sum rules are also discussed.

  20. [New italian law about end of life: self-determination and shared care pathway.

    PubMed

    Ciliberti, Rosagemma; Gulino, Matteo; Gorini, Ilaria

    2018-05-01

    The Italian Parliament has recently approved the Law n. 219/2017 concerning "Rules on informed consent and advance directives". The manuscript points out the main key points of the new law, in order to clarify the role of the advance directives and to provide clear operational guidelines for healthcare personnel. Taking into consideration the Italian deontological and juridical context, along with the main jurisprudential judgements, the law has been analysed. The Authors discussed the new rules and the bioethical issues also in relation to the provisions stated by the Convention on Human Rights and Biomedicine (Convention of Oviedo). The new law deals with relevant issues that were confined to jurisprudential rulings so far, such as the informed consent, the withdrawal/withholding of medical treatment (including artificial nutrition and hydration), the content of medical information, including the modalities, the medical responsibility and, finally, the value of advance directives. In the Authors' opinion this law provides essential rules to expressly strengthen the patients' autonomy, eliminating the juridical uncertainty on many central issues (such us, for example, the refusal of life-sustainment treatments) that have been the subject of contradictory judgments ruled by the Italian Courts. Nevertheless, advance directives should be regarded as a dynamic tools of relationship between physicians and assisted person and, thus, as an essential integrant part of the advance care planning. The education of health professionals and citizens about end of life issues is the basis for the successful implementation of this legislation.

  1. 78 FR 32487 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... and trade the shares of the following under NYSE Arca Equities Rule 8.600 (``Managed Fund Shares... proposes to list and trade the shares (``Shares'') of the PowerShares China A-Share Portfolio (``Fund... with the Commission as an open-end management investment company.\\6\\ \\4\\ A Managed Fund Share is a...

  2. 27 CFR 53.143 - Special rules relating to further manufacture.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... further manufacture. 53.143 Section 53.143 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... AND AMMUNITION Exemptions, Registration, Etc. § 53.143 Special rules relating to further manufacture... the Code for use by it in further manufacture shall be treated as the manufacturer or producer of such...

  3. Relations between emotions, display rules, social motives, and facial behaviour.

    PubMed

    Zaalberg, Ruud; Manstead, Antony; Fischer, Agneta

    2004-02-01

    We report research on the relations between emotions, display rules, social motives, and facial behaviour. In Study 1 we used a questionnaire methodology to examine how respondents would react to a funny or a not funny joke told to them by a close friend or a stranger. We assessed display rules and motivations for smiling and/or laughing. Display rules and social motives (partly) mediated the relationship between the experimental manipulations and self-reported facial behaviour. Study 2 was a laboratory experiment in which funny or not funny jokes were told to participants by a male or female stranger. Consistent with hypotheses, hearing a funny joke evoked a stronger motivation to share positive affect by showing longer Duchenne smiling. Contrary to hypotheses, a not funny joke did not elicit greater prosocial motivation by showing longer "polite" smiling, although such a smiling pattern did occur. Rated funniness of the joke and the motivation to share positive affect mediated the relationship between the joke manipulation and facial behaviour. Path analysis was used to explore this mediating process in greater detail.

  4. The New Rules of PR and Marketing: A Teaching Unit for College Public Relations Programs

    ERIC Educational Resources Information Center

    Mauldin, Candice

    2011-01-01

    The purpose of this lesson plan is to introduce the importance of social media and the Internet on public relations and marketing. The lesson describes the new rules for public relations versus the old rules. It is a more in depth look at how, and why, to use blogging, social media, and the Internet for promoting a company and appealing to buyers.…

  5. The Overtime Rule in the National Football League: Fair or Unfair?

    ERIC Educational Resources Information Center

    Gorgievski, Nicholas; DeFranco, Thomas C.; Swaminatha, Hariharan; Sofronas, Kimberly S.

    2010-01-01

    In 1974, the National Football League (NFL) initiated a sudden death overtime rule for games ending in a tie score at the end of regulation time. The rule states that the sudden death system of determining the winner shall prevail when the score is tied at the end of the regulation playing time of all NFL games. The team scoring first during…

  6. 40 CFR 60.1575 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... Before August 30, 1999 Use of Model Rule § 60.1575 How does the model rule relate to the required...

  7. Defining Alcohol-Specific Rules Among Parents of Older Adolescents: Moving Beyond No Tolerance

    PubMed Central

    Bourdeau, Beth; Miller, Brenda; Vanya, Magdalena; Duke, Michael; Ames, Genevieve

    2012-01-01

    Parental beliefs and rules regarding their teen’s use of alcohol influence teen decisions regarding alcohol use. However, measurement of parental rules regarding adolescent alcohol use has not been thoroughly studied. This study used qualitative interviews with 174 parents of older teens from 100 families. From open-ended questions, themes emerged that describe explicit rules tied to circumscribed use, no tolerance, and “call me.” There was some inconsistency in explicit rules with and between parents. Responses also generated themes relating to implicit rules such as expectations and preferences. Parents described their methods of communicating their position via conversational methods, role modeling their own behavior, teaching socially appropriate use of alcohol by offering their teen alcohol, and monitoring their teens’ social activities. Findings indicate that alcohol rules are not adequately captured by current assessment measures. PMID:23204931

  8. 40 CFR 60.2565 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 7 2012-07-01 2012-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... of Model Rule § 60.2565 How does the model rule relate to the required elements of my State plan? Use...

  9. 40 CFR 60.2565 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... of Model Rule § 60.2565 How does the model rule relate to the required elements of my State plan? Use...

  10. 40 CFR 60.2565 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... of Model Rule § 60.2565 How does the model rule relate to the required elements of my State plan? Use...

  11. N. River Street, east side of street at Sound End ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    N. River Street, east side of street at Sound End - River Street Historic District, Bounded by West Saint James Street, West Santa Clara Street, Pleasant Street, & Guadalupe River, San Jose, Santa Clara County, CA

  12. 30 CFR 784.200 - Interpretive rules related to General Performance Standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RECLAMATION AND OPERATION PLAN § 784.200 Interpretive rules related to General Performance Standards. The... ENFORCEMENT, DEPARTMENT OF THE INTERIOR SURFACE COAL MINING AND RECLAMATION OPERATIONS PERMITS AND COAL... Surface Mining Reclamation and Enforcement. (a) Interpretation of § 784.15: Reclamation plan: Postmining...

  13. Antecedents and consequences of emotional display rule perceptions.

    PubMed

    Diefendorff, James M; Richard, Erin M

    2003-04-01

    Central to all theories of emotional labor is the idea that individuals follow emotional display rules that specify the appropriate expression of emotions on the job. This investigation examined antecedents and consequences of emotional display rule perceptions. Full-time working adults (N = 152) from a variety of occupations provided self-report data, and supervisors and coworkers completed measures pertaining to the focal employees. Results using structural equation modeling revealed that job-based interpersonal requirements, supervisor display rule perceptions, and employee extraversion and neuroticism were predictive of employee display rule perceptions. Employee display rule perceptions, in turn, were related to self-reported job satisfaction and coworker ratings of employees' emotional displays on the job. Finally, neuroticism had direct negative relationships with job satisfaction and coworker ratings of employees' emotional displays.

  14. Display Rule Application in a Disappointing Situation and Children's Emotional Reactivity: Relations with Social Competence.

    ERIC Educational Resources Information Center

    McDowell, David J.; O'Neil, Robin; Parke, Ross D.

    2000-01-01

    Examined associations among emotion display rule use, negative emotional reactivity, and fourth-graders' social competence. Found negative relation between self-reported negative emotional coping strategies and observed measures of display rule use. Found children who reported using more effective coping strategies for managing negative emotions…

  15. 76 FR 44491 - Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... 37208) entitled, ``Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims..., ``Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals and... external review processes for group health plans and health insurance issuers offering coverage in the...

  16. SOUTHERN END OF ASSEMBLY PLANT, LOOKING N ON SECOND FLOOR, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SOUTHERN END OF ASSEMBLY PLANT, LOOKING N ON SECOND FLOOR, WHICH DID NOT EXIST ON DURING SHIP BUILDING DAYS. NOTE VEHICLE ELEVATOR. ABOVE AND TO THE LEFT IS SHIP BUILDING BALCONY. - B Building, 3001 Miller Road, Dearborn, MI

  17. Age-Related Differences in Contribution of Rule-Based Thinking toward Moral Evaluations.

    PubMed

    Caravita, Simona C S; De Silva, Lindamulage N; Pagani, Vera; Colombo, Barbara; Antonietti, Alessandro

    2017-01-01

    This study aims to investigate the interplay of different criteria of moral evaluation, related to the type of the rule and context characteristics, in moral reasoning of children, early, and late adolescents. Students attending to fourth, seventh, and tenth grade were asked to evaluate the acceptability of rule breaking actions using ad hoc scenarios. Results suggest that the role of different moral evaluation criteria changes by age. During adolescence a greater integration of the moral criteria emerged. Moreover, adolescents also prioritized the evaluation of moral rule (forbidding to harm others) violations as non-acceptable when the perpetrator harms an innocent victim by applying a direct personal force. The relevance of these findings to increase the understanding of how moral reasoning changes by age for the assessment of impairments in moral reasoning of non-normative groups is also discussed.

  18. Age-Related Differences in Contribution of Rule-Based Thinking toward Moral Evaluations

    PubMed Central

    Caravita, Simona C. S.; De Silva, Lindamulage N.; Pagani, Vera; Colombo, Barbara; Antonietti, Alessandro

    2017-01-01

    This study aims to investigate the interplay of different criteria of moral evaluation, related to the type of the rule and context characteristics, in moral reasoning of children, early, and late adolescents. Students attending to fourth, seventh, and tenth grade were asked to evaluate the acceptability of rule breaking actions using ad hoc scenarios. Results suggest that the role of different moral evaluation criteria changes by age. During adolescence a greater integration of the moral criteria emerged. Moreover, adolescents also prioritized the evaluation of moral rule (forbidding to harm others) violations as non-acceptable when the perpetrator harms an innocent victim by applying a direct personal force. The relevance of these findings to increase the understanding of how moral reasoning changes by age for the assessment of impairments in moral reasoning of non-normative groups is also discussed. PMID:28473788

  19. 40 CFR 60.2997 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... Construction On or Before December 9, 2004 Model Rule-Use of Model Rule § 60.2997 How does the model rule...

  20. 40 CFR 60.2997 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... Construction On or Before December 9, 2004 Model Rule-Use of Model Rule § 60.2997 How does the model rule...

  1. 40 CFR 60.2997 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... Construction On or Before December 9, 2004 Model Rule-Use of Model Rule § 60.2997 How does the model rule...

  2. 40 CFR 60.2997 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 7 2012-07-01 2012-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... Construction On or Before December 9, 2004 Model Rule-Use of Model Rule § 60.2997 How does the model rule...

  3. 40 CFR 60.2997 - How does the model rule relate to the required elements of my State plan?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES... Construction On or Before December 9, 2004 Model Rule-Use of Model Rule § 60.2997 How does the model rule...

  4. A relational ethical approach to end-of-life delirium.

    PubMed

    Wright, David Kenneth; Brajtman, Susan; Macdonald, Mary Ellen

    2014-08-01

    Delirium is a condition of acute onset and fluctuating course in which a person's level of consciousness and cognition become disturbed. Delirium is a common and distressing phenomenon in end-of-life care, yet it is underrecognized and undertreated. In this article, we review qualitative descriptions of the delirium experience in end-of-life care, found through a systematic search of academic databases, to generate insight into the intersubjective nature of the delirium experience. Our analysis of retrieved studies advances an understanding of the relational ethical dimensions of this phenomenon, that is, how delirium is lived by patients, families, and health care providers and how it affects the relationships and values at stake. We propose three themes that explain the distressing nature of delirium in palliative care: 1) experiences of relational tension; 2) challenges in recognizing the delirious person; and 3) struggles to interpret the meaning of delirious behaviors. By approaching end-of-life delirium from a perspective of relational ethics, attention is focused on the implications for the therapeutic relationship with patients and families when delirium becomes part of the dying trajectory. Copyright © 2014 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  5. Age-related changes in with-the-rule and oblique corneal astigmatism.

    PubMed

    Naeser, Kristian; Savini, Giacomo; Bregnhøj, Jesper Flethøj

    2018-01-25

    To describe the age-related changes in with-the-rule (WTR) and oblique keratometric astigmatism (KA), posterior corneal astigmatism (PCA) and total corneal astigmatism (TCA). We used a Pentacam HR (high-resolution) rotating Scheimpflug camera to determine the KA, PCA and TCA in the right eyes of 710 patients, aged from 20 to 88 years. The age-related changes along the vertical, horizontal and oblique meridians were analyzed with Naeser's polar value method in a cross-sectional study. In the whole group, all meridional astigmatic powers and polar values were stable in the age groups from 20 to 49 years, followed by a 1.0 dioptre (D) against-the-rule (ATR) change in KA and TCA, and a 0.12 D reduction in against-the-rule PCA. A nasal rotation of the steep meridian in KA and TCA was noted in the 70-88 years old. The PCA averaged approximately 0.25 D ATR in all age groups. Females displayed the same early astigmatic stability as in the whole group, while male eyes demonstrated a linear decay from 1.5 D WTR at 20 years to 0.5 D ATR astigmatism for the oldest patients. Corneal astigmatism is stable until the age of 50 years; thereafter both keratometric and total corneal astigmatism show a 0.25 D ATR change per 10 years. The average 0.25 D ATR PCA compensates the predominant keratometric WTR astigmatism in the younger patients and increases the TCA in the elderly with keratometric ATR astigmatism. The gender-based differences in age-related astigmatism require further studies. © 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  6. 20 CFR 218.38 - When a spouse annuity ends.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a spouse annuity ends. 218.38 Section... ANNUITY BEGINNING AND ENDING DATES When an Annuity Ends § 218.38 When a spouse annuity ends. (a) General rules. A spouse annuity ends with the earliest of— (1) The last day of the month before the month in...

  7. Medicare program; end-stage renal disease prospective payment system, quality incentive program, and durable medical equipment, prosthetics, orthotics, and supplies.

    PubMed

    2013-12-02

    This rule updates and makes revisions to the End-Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2014. This rule also sets forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2016 and beyond. In addition, this rule clarifies the grandfathering provision related to the 3-year minimum lifetime requirement (MLR) for Durable Medical Equipment (DME), and provides clarification of the definition of routinely purchased DME. This rule also implements budget-neutral fee schedules for splints and casts, and intraocular lenses (IOLs) inserted in a physician's office. Finally, this rule makes a few technical amendments and corrections to existing regulations related to payment for durable medical equipment, prosthetics, orthotics, and supplies (DMEPOS) items and services.

  8. Effects of collagen membranes enriched with in vitro-differentiated N1E-115 cells on rat sciatic nerve regeneration after end-to-end repair.

    PubMed

    Amado, Sandra; Rodrigues, Jorge M; Luís, Ana L; Armada-da-Silva, Paulo A S; Vieira, Márcia; Gartner, Andrea; Simões, Maria J; Veloso, António P; Fornaro, Michele; Raimondo, Stefania; Varejão, Artur S P; Geuna, Stefano; Maurício, Ana C

    2010-02-11

    Peripheral nerves possess the capacity of self-regeneration after traumatic injury but the extent of regeneration is often poor and may benefit from exogenous factors that enhance growth. The use of cellular systems is a rational approach for delivering neurotrophic factors at the nerve lesion site, and in the present study we investigated the effects of enwrapping the site of end-to-end rat sciatic nerve repair with an equine type III collagen membrane enriched or not with N1E-115 pre-differentiated neural cells. After neurotmesis, the sciatic nerve was repaired by end-to-end suture (End-to-End group), end-to-end suture enwrapped with an equine collagen type III membrane (End-to-EndMemb group); and end-to-end suture enwrapped with an equine collagen type III membrane previously covered with neural cells pre-differentiated in vitro from N1E-115 cells (End-to-EndMembCell group). Along the postoperative, motor and sensory functional recovery was evaluated using extensor postural thrust (EPT), withdrawal reflex latency (WRL) and ankle kinematics. After 20 weeks animals were sacrificed and the repaired sciatic nerves were processed for histological and stereological analysis. Results showed that enwrapment of the rapair site with a collagen membrane, with or without neural cell enrichment, did not lead to any significant improvement in most of functional and stereological predictors of nerve regeneration that we have assessed, with the exception of EPT which recovered significantly better after neural cell enriched membrane employment. It can thus be concluded that this particular type of nerve tissue engineering approach has very limited effects on nerve regeneration after sciatic end-to-end nerve reconstruction in the rat.

  9. A Theory of the von Weimarn Rules Governing the Average Size of Crystals Precipitated from a Supersaturated Solution

    NASA Technical Reports Server (NTRS)

    Barlow, Douglas A.; Baird, James K.; Su, Ching-Hua

    2003-01-01

    More than 75 years ago, von Weimarn summarized his observations of the dependence of the average crystal size on the initial relative concentration supersaturation prevailing in a solution from which crystals were growing. Since then, his empirically derived rules have become part of the lore of crystal growth. The first of these rules asserts that the average crystal size measured at the end of a crystallization increases as the initial value of the relative supersaturation decreases. The second rule states that for a given crystallization time, the average crystal size passes through a maximum as a function of the initial relative supersaturation. Using a theory of nucleation and growth due to Buyevich and Mansurov, we calculate the average crystal size as a function of the initial relative supersaturation. We confirm the von Weimarn rules for the case where the nucleation rate is proportional to the third power or higher of the relative supersaturation.

  10. Schedules of controlled substances: placement of 5-methoxy-N,N-dimethyltryptamine into Schedule I of the Controlled Substances Act. Final rule.

    PubMed

    2010-12-20

    With the issuance of this final rule, the Deputy Administrator of the Drug Enforcement Administration (DEA) places the substance 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), including its salts, isomers and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible, into schedule I of the Controlled Substances Act (CSA). This action by the DEA Deputy Administrator is based on a scheduling recommendation from the Assistant Secretary for Health of the Department of Health and Human Services (DHHS) and a DEA review indicating that 5-MeO-DMT meets the criteria for placement in schedule I of the CSA. This final rule will impose the criminal sanctions and regulatory controls of schedule I substances under the CSA on the manufacture, distribution, dispensing, importation, exportation, and possession of 5-MeO-DMT.

  11. Highly scalable and robust rule learner: performance evaluation and comparison.

    PubMed

    Kurgan, Lukasz A; Cios, Krzysztof J; Dick, Scott

    2006-02-01

    Business intelligence and bioinformatics applications increasingly require the mining of datasets consisting of millions of data points, or crafting real-time enterprise-level decision support systems for large corporations and drug companies. In all cases, there needs to be an underlying data mining system, and this mining system must be highly scalable. To this end, we describe a new rule learner called DataSqueezer. The learner belongs to the family of inductive supervised rule extraction algorithms. DataSqueezer is a simple, greedy, rule builder that generates a set of production rules from labeled input data. In spite of its relative simplicity, DataSqueezer is a very effective learner. The rules generated by the algorithm are compact, comprehensible, and have accuracy comparable to rules generated by other state-of-the-art rule extraction algorithms. The main advantages of DataSqueezer are very high efficiency, and missing data resistance. DataSqueezer exhibits log-linear asymptotic complexity with the number of training examples, and it is faster than other state-of-the-art rule learners. The learner is also robust to large quantities of missing data, as verified by extensive experimental comparison with the other learners. DataSqueezer is thus well suited to modern data mining and business intelligence tasks, which commonly involve huge datasets with a large fraction of missing data.

  12. Feynman-like rules for calculating n-point correlators of the primordial curvature perturbation

    NASA Astrophysics Data System (ADS)

    Valenzuela-Toledo, César A.; Rodríguez, Yeinzon; Beltrán Almeida, Juan P.

    2011-10-01

    A diagrammatic approach to calculate n-point correlators of the primordial curvature perturbation ζ was developed a few years ago following the spirit of the Feynman rules in Quantum Field Theory. The methodology is very useful and time-saving, as it is for the case of the Feynman rules in the particle physics context, but, unfortunately, is not very well known by the cosmology community. In the present work, we extend such an approach in order to include not only scalar field perturbations as the generators of ζ, but also vector field perturbations. The purpose is twofold: first, we would like the diagrammatic approach (which we would call the Feynman-like rules) to become widespread among the cosmology community; second, we intend to give an easy tool to formulate any correlator of ζ for those cases that involve vector field perturbations and that, therefore, may generate prolonged stages of anisotropic expansion and/or important levels of statistical anisotropy. Indeed, the usual way of formulating such correlators, using the Wick's theorem, may become very clutter and time-consuming.

  13. Death talk: Basic linguistic rules and communication in perinatal and paediatric end-of-life discussions.

    PubMed

    Xafis, Vicki; Watkins, Andrew; Wilkinson, Dominic

    2016-04-01

    This paper considers clinician/parent communication difficulties noted by parents involved in end-of-life decision-making in the light of linguistic theory. Grice's Cooperative Principle and associated maxims, which enable effective communication, are examined in relation to communication deficiencies that parents have identified when making end-of-life decisions for the child. Examples from the literature are provided to clarify the impact of failing to observe the maxims on parents and on clinician/parent communication. Linguistic theory applied to the literature on parental concerns about clinician/parent communication shows that the violation of the maxims of quantity, quality, relation, and manner as well as the stance that some clinicians adopt during discussions with parents impact on clinician/parent communication and lead to distrust, anger, sadness, and long-term difficulties coping with the experience of losing one's child. Parents have identified communication deficiencies in end-of-life discussions. Relating these communication deficiencies to linguistic theory provides insight into communication difficulties but also solutions. Gaining an understanding of basic linguistic theory that underlies human interactions, gaining insight into the communication deficiencies that parents have identified, and modifying some communication behaviours in light of these with the suggestions made in this article may lead to improved clinician/parent communication. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. Algebraic Approaches for Scalable End-to-End Monitoring and Diagnosis

    NASA Astrophysics Data System (ADS)

    Zhao, Yao; Chen, Yan

    The rigidity of the Internet architecture led to flourish in the research of end-to-end based systems. In this chapter, we describe a linear algebra-based end-to-end monitoring and diagnosis system. We first propose a tomography-based overlay monitoring system (TOM). Given n end hosts, TOM selectively monitors a basis set of O(nlogn) paths out of all n(n - 1) end-to-end paths. Any end-to-end path can be written as a unique linear combination of paths in the basis set. Consequently, by monitoring loss rates for the paths in the basis set, TOM infers loss rates for all end-to-end paths. Furthermore, leveraging on the scalable measurements from the TOM system, we propose the Least-biased End-to-End Network Diagnosis (in short, LEND) system. We define a minimal identifiable link sequence (MILS) as a link sequence of minimal length whose properties can be uniquely identified from end-to-end measurements. LEND applies an algebraic approach to find out the MILSes and infers the properties of the MILSes efficiently. This also means LEND system achieves the finest diagnosis granularity under the least biased statistical assumptions.

  15. Effects of collagen membranes enriched with in vitro-differentiated N1E-115 cells on rat sciatic nerve regeneration after end-to-end repair

    PubMed Central

    2010-01-01

    Peripheral nerves possess the capacity of self-regeneration after traumatic injury but the extent of regeneration is often poor and may benefit from exogenous factors that enhance growth. The use of cellular systems is a rational approach for delivering neurotrophic factors at the nerve lesion site, and in the present study we investigated the effects of enwrapping the site of end-to-end rat sciatic nerve repair with an equine type III collagen membrane enriched or not with N1E-115 pre-differentiated neural cells. After neurotmesis, the sciatic nerve was repaired by end-to-end suture (End-to-End group), end-to-end suture enwrapped with an equine collagen type III membrane (End-to-EndMemb group); and end-to-end suture enwrapped with an equine collagen type III membrane previously covered with neural cells pre-differentiated in vitro from N1E-115 cells (End-to-EndMembCell group). Along the postoperative, motor and sensory functional recovery was evaluated using extensor postural thrust (EPT), withdrawal reflex latency (WRL) and ankle kinematics. After 20 weeks animals were sacrificed and the repaired sciatic nerves were processed for histological and stereological analysis. Results showed that enwrapment of the rapair site with a collagen membrane, with or without neural cell enrichment, did not lead to any significant improvement in most of functional and stereological predictors of nerve regeneration that we have assessed, with the exception of EPT which recovered significantly better after neural cell enriched membrane employment. It can thus be concluded that this particular type of nerve tissue engineering approach has very limited effects on nerve regeneration after sciatic end-to-end nerve reconstruction in the rat. PMID:20149260

  16. Modeling of a C-end rule peptide adsorbed onto gold nanoparticles.

    PubMed

    Triguero, Jordi; Flores-Ortega, Alejandra; Zanuy, David; Alemán, Carlos

    2018-01-01

    The RPAR peptide, a prototype C-end Rule (CendR) sequence that binds to neuropilin-1 (NRP-1), has potential therapeutic uses as internalization trigger in anticancer nanodevices. Recently, the functionalization of gold nanoparticles with CendR peptides has been proved to be a successful strategy to target the NRP-1 receptor in prostate cancer cells. In this work, we investigate the influence of two gold surface facets, (100) and (111), on the conformational preferences of RPAR using molecular dynamics simulations. Both clustering and conformational analyses revealed that the peptide backbone becomes very rigid upon adsorption onto gold, which is a very fast and favored process, the only flexibility being attributed to the side chains of the two Arg residues. Thus, the different components of RPAR tend to adopt an elongated shape, which is characterized by the pseudo-extended conformation of both the backbone and the Arg side chains. This conformation is very different from the already known bioactive conformation, indicating that RPAR is drastically affected by the substrate. Interestingly, the preferred conformations of the peptide adsorbed onto gold facets are not stabilized by salt bridges and/or specific intramolecular hydrogen bonds, which represent an important difference with respect to the conformations found in other environments (e.g. the peptide in solution and interacting with NRP-1 receptor). However, the conformational changes induced by the substrate are not detrimental for the use of gold nanoparticles as appropriate vehicles for the transport and targeted delivery of the RPAR. Thus, once their high affinity for the NRP-1 receptor induces the targeted delivery of the elongated peptide molecules from the gold nanoparticles, the lack of intramolecular interactions facilitates their evolution towards the bioactive conformation, increasing the therapeutic efficacy of the peptide. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.

  17. The neural implementation of task rule activation in the task-cuing paradigm: an event-related fMRI study.

    PubMed

    Shi, Yiquan; Zhou, Xiaolin; Müller, Hermann J; Schubert, Torsten

    2010-07-01

    To isolate the neural correlates for task rule activation from those related to general task preparation, the effect of a cue explicitly specifying the S-R correspondences (rule-cue) was contrasted with the effects of a cue specifying only the task to performed (task-cue). While the task-cue provides merely information about the type of task, the rule-cue is explicit about both the task type and the task rule (i.e., the set of S-R correspondences). The rule-cue was expected to activate the task rule more efficiently in the preparation period (prior to target presentation); by contrast, in the task-cue condition, part of the task rule activation was expected to be postponed into the task execution period (following the presentation of the target). In an event-related fMRI experiment, we found the right anterior and middle parts of the middle frontal and superior frontal gyri, the right inferior frontal junction, the pre-SMA, as well as the right superior and inferior parietal lobes to show larger activation elicited by the rule-cue than by the task-cue prior to target presentation. Conversely, the results revealed larger activations in these regions in the task-cue than in the rule-cue condition during the task execution period. In summary, this study identified some of the neural correlates of task rule activation and showed that these are a subset of the general task preparation network. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  18. Rules based process window OPC

    NASA Astrophysics Data System (ADS)

    O'Brien, Sean; Soper, Robert; Best, Shane; Mason, Mark

    2008-03-01

    As a preliminary step towards Model-Based Process Window OPC we have analyzed the impact of correcting post-OPC layouts using rules based methods. Image processing on the Brion Tachyon was used to identify sites where the OPC model/recipe failed to generate an acceptable solution. A set of rules for 65nm active and poly were generated by classifying these failure sites. The rules were based upon segment runlengths, figure spaces, and adjacent figure widths. 2.1 million sites for active were corrected in a small chip (comparing the pre and post rules based operations), and 59 million were found at poly. Tachyon analysis of the final reticle layout found weak margin sites distinct from those sites repaired by rules-based corrections. For the active layer more than 75% of the sites corrected by rules would have printed without a defect indicating that most rulesbased cleanups degrade the lithographic pattern. Some sites were missed by the rules based cleanups due to either bugs in the DRC software or gaps in the rules table. In the end dramatic changes to the reticle prevented catastrophic lithography errors, but this method is far too blunt. A more subtle model-based procedure is needed changing only those sites which have unsatisfactory lithographic margin.

  19. 43 CFR 4.100 - General rules and guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false General rules and guidelines. 4.100... rules and guidelines. (a) Effective date and applicability—(1) Effective date and general applicability..., in which event the period shall run to the end of the next business day. (e) General guidelines—(1...

  20. Perceptions of Rule-Breaking Related to Marine Ecosystem Health

    PubMed Central

    Slater, Matthew J.; Mgaya, Yunus D.; Stead, Selina M.

    2014-01-01

    Finding effective solutions to manage marine resources is high on political and conservation agendas worldwide. This is made more urgent by the rate of increase in the human population and concomitant resource pressures in coastal areas. This paper links empirical socio-economic data about perceptions of marine resource health to the breaking of marine management rules, using fisheries as a case study. The relationship between perceived rule-breaking (non-compliance with regulations controlling fishing) and perceived health of inshore marine environments was investigated through face-to-face interviews with 299 heads of households in three Tanzanian coastal communities in November and December 2011. Awareness of rules controlling fishing activity was high among all respondents. Fishers were able to describe more specific rules controlling fishing practices than non-fishers (t = 3.5, df = 297, p<0.01). Perceived breaking of fishing regulations was reported by nearly half of all respondents, saying “some” (32% of responses) or “most” (15% of responses) people break fishing rules. Ordinal regression modelling revealed a significant linkage (z = −3.44, p<0.001) in the relationship between respondents' perceptions of deteriorating marine health and their perception of increased rule-breaking. In this paper, inferences from an empirical study are used to identify and argue the potential for using perceptions of ecosystem health and level of rule-breaking as a means to guide management measures. When considering different management options (e.g. Marine Protected Areas), policy makers are advised to take account of and utilise likely egoistic or altruistic decision-making factors used by fishers to determine their marine activities. PMID:24586558

  1. Perceptions of rule-breaking related to marine ecosystem health.

    PubMed

    Slater, Matthew J; Mgaya, Yunus D; Stead, Selina M

    2014-01-01

    Finding effective solutions to manage marine resources is high on political and conservation agendas worldwide. This is made more urgent by the rate of increase in the human population and concomitant resource pressures in coastal areas. This paper links empirical socio-economic data about perceptions of marine resource health to the breaking of marine management rules, using fisheries as a case study. The relationship between perceived rule-breaking (non-compliance with regulations controlling fishing) and perceived health of inshore marine environments was investigated through face-to-face interviews with 299 heads of households in three Tanzanian coastal communities in November and December 2011. Awareness of rules controlling fishing activity was high among all respondents. Fishers were able to describe more specific rules controlling fishing practices than non-fishers (t = 3.5, df = 297, p<0.01). Perceived breaking of fishing regulations was reported by nearly half of all respondents, saying "some" (32% of responses) or "most" (15% of responses) people break fishing rules. Ordinal regression modelling revealed a significant linkage (z= -3.44, p<0.001) in the relationship between respondents' perceptions of deteriorating marine health and their perception of increased rule-breaking. In this paper, inferences from an empirical study are used to identify and argue the potential for using perceptions of ecosystem health and level of rule-breaking as a means to guide management measures. When considering different management options (e.g. Marine Protected Areas), policy makers are advised to take account of and utilise likely egoistic or altruistic decision-making factors used by fishers to determine their marine activities.

  2. Born’s rule as signature of a superclassical current algebra

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fussy, S.; Mesa Pascasio, J.; Institute for Atomic and Subatomic Physics, Vienna University of Technology, Operng. 9, 1040 Vienna

    2014-04-15

    We present a new tool for calculating the interference patterns and particle trajectories of a double-, three- and N-slit system on the basis of an emergent sub-quantum theory developed by our group throughout the last years. The quantum itself is considered as an emergent system representing an off-equilibrium steady state oscillation maintained by a constant throughput of energy provided by a classical zero-point energy field. We introduce the concept of a “relational causality” which allows for evaluating structural interdependences of different systems levels, i.e. in our case of the relations between partial and total probability density currents, respectively. Combined with themore » application of 21st century classical physics like, e.g., modern nonequilibrium thermodynamics, we thus arrive at a “superclassical” theory. Within this framework, the proposed current algebra directly leads to a new formulation of the guiding equation which is equivalent to the original one of the de Broglie–Bohm theory. By proving the absence of third order interferences in three-path systems it is shown that Born’s rule is a natural consequence of our theory. Considering the series of one-, double-, or, generally, of N-slit systems, with the first appearance of an interference term in the double slit case, we can explain the violation of Sorkin’s first order sum rule, just as the validity of all higher order sum rules. Moreover, the Talbot patterns and Talbot distance for an arbitrary N-slit device can be reproduced exactly by our model without any quantum physics tool. -- Highlights: •Calculating the interference patterns and particle trajectories of a double-, three- and N-slit system. •Deriving a new formulation of the guiding equation equivalent to the de Broglie–Bohm one. •Proving the absence of third order interferences and thus explaining Born’s rule. •Explaining the violation of Sorkin’s order sum rules. •Classical simulation of Talbot

  3. Measure in the ESRD QIP for PY 2020. Final rule.

    PubMed

    2017-08-04

    This final rule updates the payment rates used under the prospective payment system (PPS) for skilled nursing facilities (SNFs) for fiscal year (FY) 2018. It also revises and rebases the market basket index by updating the base year from 2010 to 2014, and by adding a new cost category for Installation, Maintenance, and Repair Services. The rule also finalizes revisions to the SNF Quality Reporting Program (QRP), including measure and standardized resident assessment data policies and policies related to public display. In addition, it finalizes policies for the Skilled Nursing Facility Value-Based Purchasing Program that will affect Medicare payment to SNFs beginning in FY 2019. The final rule also clarifies the regulatory requirements for team composition for surveys conducted for investigating a complaint and aligns regulatory provisions for investigation of complaints with the statutory requirements. The final rule also finalizes the performance period for the National Healthcare Safety Network (NHSN) Healthcare Personnel (HCP) Influenza Vaccination Reporting Measure included in the End-Stage Renal Disease (ESRD) Quality Incentive Program (QIP) for Payment Year 2020.

  4. Bioethical aspects of end-of-life care.

    PubMed

    Zamperetti, N; Bellomo, R; Ronco, C

    2008-01-01

    Managing end-of-life care can be difficult because of the particular nature of intensive care support, which can separate the biological and the biographical aspects of life. Artificial organ support can temporarily delay death but, at the same time, may fail to restore a quality of life that the patient judges acceptable. For this reason, two concepts must be considered: that the mission of the healthcare system should be to care for patients according to their interests and wishes and that quality of care is related above all to the careful commitment of healthcare workers to the patient's best interests. Keeping these concepts in mind, the rule of the five Cs (competence, collegiality, communication, continuity of care and compassion) might be helpful in the management of end-of-life care. Unfortunately, neither the rule of the five Cs nor the careful use of moral principles in order to promote the patients' dignity can assure a universally acceptable decision. A reasonable level of 'moral certainty', however, might be achieved using a deliberative approach, which provides for the inclusion of all the different subjects involved in the decision-making process (patient, family, doctors, nurses and other carers), in order to reach the best possible decision in a specific situation.

  5. 49 CFR 393.130 - What are the rules for securing heavy vehicles, equipment and machinery?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., equipment and machinery? 393.130 Section 393.130 Transportation Other Regulations Relating to Transportation... heavy vehicles, equipment and machinery? (a) Applicability. The rules in this section apply to the transportation of heavy vehicles, equipment and machinery which operate on wheels or tracks, such as front end...

  6. 49 CFR 393.130 - What are the rules for securing heavy vehicles, equipment and machinery?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., equipment and machinery? 393.130 Section 393.130 Transportation Other Regulations Relating to Transportation... heavy vehicles, equipment and machinery? (a) Applicability. The rules in this section apply to the transportation of heavy vehicles, equipment and machinery which operate on wheels or tracks, such as front end...

  7. 49 CFR 393.130 - What are the rules for securing heavy vehicles, equipment and machinery?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., equipment and machinery? 393.130 Section 393.130 Transportation Other Regulations Relating to Transportation... heavy vehicles, equipment and machinery? (a) Applicability. The rules in this section apply to the transportation of heavy vehicles, equipment and machinery which operate on wheels or tracks, such as front end...

  8. Electronic nicotine delivery system (ENDS) battery-related burns presenting to US emergency departments, 2016.

    PubMed

    Corey, Catherine G; Chang, Joanne T; Rostron, Brian L

    2018-03-05

    Currently, an estimated 7.9 million US adults use electronic nicotine delivery systems (ENDS). Although published reports have identified fires and explosions related to use of ENDS since 2009, these reports do not provide national estimates of burn injuries associated with ENDS batteries in the US. We analyzed nationally representative data provided in the National Electronic Injury Surveillance System (NEISS) to estimate the number of US emergency department (ED) visits for burn injuries associated with ENDS batteries. We reviewed the case narrative field to gain additional insights into the circumstances of the burn injury. In 2016, 26 ENDS battery-related burn cases were captured by NEISS, which translates to a national estimate of 1007 (95%CI: 357-1657) injuries presenting in US EDs. Most of the burns were thermal burns (80.4%) and occurred to the upper leg/lower trunk (77.3%). Examination of the case narrative field indicated that at least 20 of the burn injuries occurred while ENDS batteries were in the user's pocket. Our study provides valuable information for understanding the current burden of ENDS battery-related burn injuries treated in US EDs. The nature and circumstances of the injuries suggest these incidents were unintentional and would potentially be prevented through battery design requirements, battery testing standards and public education related to ENDS battery safety.

  9. Portable design rules for bulk CMOS

    NASA Technical Reports Server (NTRS)

    Griswold, T. W.

    1982-01-01

    It is pointed out that for the past several years, one school of IC designers has used a simplified set of nMOS geometric design rules (GDR) which is 'portable', in that it can be used by many different nMOS manufacturers. The present investigation is concerned with a preliminary set of design rules for bulk CMOS which has been verified for simple test structures. The GDR are defined in terms of Caltech Intermediate Form (CIF), which is a geometry-description language that defines simple geometrical objects in layers. The layers are abstractions of physical mask layers. The design rules do not presume the existence of any particular design methodology. Attention is given to p-well and n-well CMOS processes, bulk CMOS and CMOS-SOS, CMOS geometric rules, and a description of the advantages of CMOS technology.

  10. DNA Packaging Specificity of Bacteriophage N15 with an Excursion into the Genetics of a Cohesive End Mismatch

    PubMed Central

    Feiss, Michael; Young Min, Jea; Sultana, Sawsan; Patel, Priyal; Sippy, Jean

    2015-01-01

    During DNA replication by the λ-like bacteriophages, immature concatemeric DNA is produced by rolling circle replication. The concatemers are processed into mature chromosomes with cohesive ends, and packaged into prohead shells, during virion assembly. Cohesive ends are generated by the viral enzyme terminase, which introduces staggered nicks at cos, an approx. 200 bp-long sequence containing subsites cosQ, cosN and cosB. Interactions of cos subsites of immature concatemeric DNA with terminase orchestrate DNA processing and packaging. To initiate DNA packaging, terminase interacts with cosB and nicks cosN. The cohesive ends of N15 DNA differ from those of λ at 2/12 positions. Genetic experiments show that phages with chromosomes containing mismatched cohesive ends are functional. In at least some infections, the cohesive end mismatch persists through cyclization and replication, so that progeny phages of both allelic types are produced in the infected cell. N15 possesses an asymmetric packaging specificity: N15 DNA is not packaged by phages λ or 21, but surprisingly, N15-specific terminase packages λ DNA. Implications for genetic interactions among λ-like bacteriophages are discussed. PMID:26633301

  11. Statistical inference of static analysis rules

    NASA Technical Reports Server (NTRS)

    Engler, Dawson Richards (Inventor)

    2009-01-01

    Various apparatus and methods are disclosed for identifying errors in program code. Respective numbers of observances of at least one correctness rule by different code instances that relate to the at least one correctness rule are counted in the program code. Each code instance has an associated counted number of observances of the correctness rule by the code instance. Also counted are respective numbers of violations of the correctness rule by different code instances that relate to the correctness rule. Each code instance has an associated counted number of violations of the correctness rule by the code instance. A respective likelihood of the validity is determined for each code instance as a function of the counted number of observances and counted number of violations. The likelihood of validity indicates a relative likelihood that a related code instance is required to observe the correctness rule. The violations may be output in order of the likelihood of validity of a violated correctness rule.

  12. 12 CFR 202.7 - Rules concerning extensions of credit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Rules concerning extensions of credit. 202.7... EQUAL CREDIT OPPORTUNITY ACT (REGULATION B) § 202.7 Rules concerning extensions of credit. (a.... (c) Action concerning existing open-end accounts—(1) Limitations. In the absence of evidence of the...

  13. 43 CFR 4.801 - Suspension of rules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Special Procedural Rules Applicable to Practice and Procedure for Hearings, Decisions, and Administrative... determination that no party will be unduly prejudiced and the ends of justice will thereby be served. ...

  14. 43 CFR 4.801 - Suspension of rules.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Special Procedural Rules Applicable to Practice and Procedure for Hearings, Decisions, and Administrative... determination that no party will be unduly prejudiced and the ends of justice will thereby be served. ...

  15. 43 CFR 4.801 - Suspension of rules.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Special Procedural Rules Applicable to Practice and Procedure for Hearings, Decisions, and Administrative... determination that no party will be unduly prejudiced and the ends of justice will thereby be served. ...

  16. 43 CFR 4.801 - Suspension of rules.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Special Procedural Rules Applicable to Practice and Procedure for Hearings, Decisions, and Administrative... determination that no party will be unduly prejudiced and the ends of justice will thereby be served. ...

  17. Modified Kramers-Kronig relations and sum rules for meromorphic total refractive index

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peiponen, Kai-Erik; Saarinen, Jarkko J.; Vartiainen, Erik M.

    2003-08-01

    Modified Kramers-Kronig relations and corresponding sum rules are shown to hold for the total refractive index that can be presented as a sum of complex linear and nonlinear refractive indices, respectively. It is suggested that a self-action process, involving the degenerate third-order nonlinear susceptibility, can yield a negative total refractive index at some spectral range.

  18. Feasibility of automatic evaluation of clinical rules in general practice.

    PubMed

    Opondo, Dedan; Visscher, Stefan; Eslami, Saied; Medlock, Stephanie; Verheij, Robert; Korevaar, Joke C; Abu-Hanna, Ameen

    2017-04-01

    To assess the extent to which clinical rules (CRs) can be implemented for automatic evaluation of quality of care in general practice. We assessed 81 clinical rules (CRs) adapted from a subset of Assessing Care of Vulnerable Elders (ACOVE) clinical rules, against Dutch College of General Practitioners (NHG) data model. Each CR was analyzed using the Logical Elements Rule METHOD: (LERM). LERM is a stepwise method of assessing and formalizing clinical rules for decision support. Clinical rules that satisfied the criteria outlined in the LERM method were judged to be implementable in automatic evaluation in general practice. Thirty-three out of 81 (40.7%) Dutch-translated ACOVE clinical rules can be automatically evaluated in electronic medical record systems. Seven out of 7 CRs (100%) in the domain of diabetes can be automatically evaluated, 9/17 (52.9%) in medication use, 5/10 (50%) in depression care, 3/6 (50%) in nutrition care, 6/13 (46.1%) in dementia care, 1/6 (16.6%) in end of life care, 2/13 (15.3%) in continuity of care, and 0/9 (0%) in the fall-related care. Lack of documentation of care activities between primary and secondary health facilities and ambiguous formulation of clinical rules were the main reasons for the inability to automate the clinical rules. Approximately two-fifths of the primary care Dutch ACOVE-based clinical rules can be automatically evaluated. Clear definition of clinical rules, improved GP database design and electronic linkage of primary and secondary healthcare facilities can improve prospects of automatic assessment of quality of care. These findings are relevant especially because the Netherlands has very high automation of primary care. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. 17 CFR 147.1 - General policy considerations, purpose and scope of rules relating to open Commission meetings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false General policy considerations, purpose and scope of rules relating to open Commission meetings. 147.1 Section 147.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION OPEN COMMISSION MEETINGS § 147.1 General policy considerations, purpose and scope of rules...

  20. Multiple-rule bias in the comparison of classification rules

    PubMed Central

    Yousefi, Mohammadmahdi R.; Hua, Jianping; Dougherty, Edward R.

    2011-01-01

    Motivation: There is growing discussion in the bioinformatics community concerning overoptimism of reported results. Two approaches contributing to overoptimism in classification are (i) the reporting of results on datasets for which a proposed classification rule performs well and (ii) the comparison of multiple classification rules on a single dataset that purports to show the advantage of a certain rule. Results: This article provides a careful probabilistic analysis of the second issue and the ‘multiple-rule bias’, resulting from choosing a classification rule having minimum estimated error on the dataset. It quantifies this bias corresponding to estimating the expected true error of the classification rule possessing minimum estimated error and it characterizes the bias from estimating the true comparative advantage of the chosen classification rule relative to the others by the estimated comparative advantage on the dataset. The analysis is applied to both synthetic and real data using a number of classification rules and error estimators. Availability: We have implemented in C code the synthetic data distribution model, classification rules, feature selection routines and error estimation methods. The code for multiple-rule analysis is implemented in MATLAB. The source code is available at http://gsp.tamu.edu/Publications/supplementary/yousefi11a/. Supplementary simulation results are also included. Contact: edward@ece.tamu.edu Supplementary Information: Supplementary data are available at Bioinformatics online. PMID:21546390

  1. Rules of co-occurring mutations characterize the antigenic evolution of human influenza A/H3N2, A/H1N1 and B viruses.

    PubMed

    Chen, Haifen; Zhou, Xinrui; Zheng, Jie; Kwoh, Chee-Keong

    2016-12-05

    The human influenza viruses undergo rapid evolution (especially in hemagglutinin (HA), a glycoprotein on the surface of the virus), which enables the virus population to constantly evade the human immune system. Therefore, the vaccine has to be updated every year to stay effective. There is a need to characterize the evolution of influenza viruses for better selection of vaccine candidates and the prediction of pandemic strains. Studies have shown that the influenza hemagglutinin evolution is driven by the simultaneous mutations at antigenic sites. Here, we analyze simultaneous or co-occurring mutations in the HA protein of human influenza A/H3N2, A/H1N1 and B viruses to predict potential mutations, characterizing the antigenic evolution. We obtain the rules of mutation co-occurrence using association rule mining after extracting HA1 sequences and detect co-mutation sites under strong selective pressure. Then we predict the potential drifts with specific mutations of the viruses based on the rules and compare the results with the "observed" mutations in different years. The sites under frequent mutations are in antigenic regions (epitopes) or receptor binding sites. Our study demonstrates the co-occurring site mutations obtained by rule mining can capture the evolution of influenza viruses, and confirms that cooperative interactions among sites of HA1 protein drive the influenza antigenic evolution.

  2. 26 CFR 1.412(c)(3)-2 - Effective dates and transitional rules relating to reasonable funding methods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to reasonable funding methods. 1.412(c)(3)-2 Section 1.412(c)(3)-2 Internal Revenue INTERNAL REVENUE... reasonable funding methods. (a) Introduction. This section prescribes effective dates for rules relating to reasonable funding methods, under section 412(c)(3) and § 1.412(c)(3)-1. Also, this section sets forth rules...

  3. 75 FR 81697 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... are subject to the provisions of Rule 204A-1 under the Advisers Act relating to codes of ethics. This Rule requires investment advisers to adopt a code of ethics that reflects the fiduciary nature of the... designed to prevent the communication and misuse of non-public information by an investment adviser must be...

  4. Rough Evaluation Structure: Application of Rough Set Theory to Generate Simple Rules for Inconsistent Preference Relation

    NASA Astrophysics Data System (ADS)

    Gehrmann, Andreas; Nagai, Yoshimitsu; Yoshida, Osamu; Ishizu, Syohei

    Since management decision-making becomes complex and preferences of the decision-maker frequently becomes inconsistent, multi-attribute decision-making problems were studied. To represent inconsistent preference relation, the concept of evaluation structure was introduced. We can generate simple rules to represent inconsistent preference relation by the evaluation structures. Further rough set theory for the preference relation was studied and the concept of approximation was introduced. One of our main aims of this paper is to introduce a concept of rough evaluation structure for representing inconsistent preference relation. We apply rough set theory to the evaluation structure, and develop a method for generating simple rules for inconsistent preference relations. In this paper, we introduce concepts of totally ordered information system, similarity class of preference relation, upper and lower approximation of preference relations. We also show the properties of rough evaluation structure and provide a simple example. As an application of rough evaluation structure, we analyze questionnaire survey of customer preferences about audio players.

  5. The dead donor rule: effect on the virtuous practice of medicine.

    PubMed

    Chaten, Frank C

    2014-07-01

    The President's Council on Bioethics in 2008 reaffirmed the necessity of the dead donor rule and the legitimacy of the current criteria for diagnosing both neurological and cardiac death. In spite of this report,many have continued to express concerns about the ethics of donation after circulatory death, the validity of determining death using neurological criteria and the necessity for maintaining the dead donor rule for organ donation. I analysed the dead donor rule for its effect on the virtuous practice of medicine by physicians caring for potential organ donors. The dead donor rule consistently impedes physicians in fulfilling their primary duty to act for the good of their prospective donor patients. This compromises the virtue of fidelity. It also weakens many other virtues necessary for physicians to provide excellent end-of-life care. The dead donor rule, while ethically powerful in theory, loses its force during translation to the bedside. This is so because the rule mandates simultaneous life and death within the same body for organ donation, a biological status that is inherently contradictory. The rule should be rejected as an ethical norm governing vital organ transplantation at the end of life. Its elimination will strengthen the doctor–patient relationship and foster trustworthiness in organ procurement.

  6. Generalization of Faddeev-Popov rules in Yang-Mills theories: N = 3,4 BRST symmetries

    NASA Astrophysics Data System (ADS)

    Reshetnyak, Alexander

    2018-01-01

    The Faddeev-Popov rules for a local and Poincaré-covariant Lagrangian quantization of a gauge theory with gauge group are generalized to the case of an invariance of the respective quantum actions, S(N), with respect to N-parametric Abelian SUSY transformations with odd-valued parameters λp, p = 1,…,N and generators sp: spsq + sqsp = 0, for N = 3, 4, implying the substitution of an N-plet of ghost fields, Cp, instead of the parameter, ξ, of infinitesimal gauge transformations: ξ = Cpλ p. The total configuration spaces of fields for a quantum theory of the same classical model coincide in the N = 3 and N = 4 symmetric cases. The superspace of N = 3 SUSY irreducible representation includes, in addition to Yang-Mills fields 𝒜μ, (3 + 1) ghost odd-valued fields Cp, B̂ and 3 even-valued Bpq for p, q = 1, 2, 3. To construct the quantum action, S(3), by adding to the classical action, S0(𝒜), of an N = 3-exact gauge-fixing term (with gauge fermion), a gauge-fixing procedure requires (1 + 3 + 3 + 1) additional fields, Φ¯(3): antighost C¯, 3 even-valued Bp, 3 odd-valued B̂pq and Nakanishi-Lautrup B fields. The action of N = 3 transformations on new fields as N = 3-irreducible representation space is realized. These transformations are the N = 3 BRST symmetry transformations for the vacuum functional, Z3(0) =∫dΦ(3)dΦ¯(3)exp{(ı/ℏ)S(3)}. The space of all fields (Φ(3),Φ¯(3)) proves to be the space of an irreducible representation of the fields Φ(4) for N = 4-parametric SUSY transformations, which contains, in addition to 𝒜μ the (4 + 6 + 4 + 1) ghost-antighost, Cr = (Cp,C¯), even-valued, Brs = -Bsr = (Bpq,Bp4 = Bp), odd-valued B̂r = (B̂,B̂pq) and B fields. The quantum action is constructed by adding to S0(𝒜) an N = 4-exact gauge-fixing term with a gauge boson, F(4). The N = 4 SUSY transformations are by N = 4 BRST transformations for the vacuum functional, Z4(0) =∫dΦ(4)exp{(ı/ℏ)S(4)}. The procedures are valid for

  7. 26 CFR 1.304-4 - Special rule for the use of related corporations to avoid the application of section 304.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Special rule for the use of related corporations... SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Effects on Recipients § 1.304-4 Special rule for the use of related corporations to avoid the application of section 304...

  8. 40 CFR 60.5075 - How does the model rule relate to the required elements of my state plan?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false How does the model rule relate to the... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Existing Sewage Sludge Incineration Units Use of Model Rule...

  9. 76 FR 12896 - References to Credit Ratings in Certain Investment Company Act Rules and Forms

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ... several releases that the Securities and Exchange Commission (``Commission'') will be considering relating... Conditional Demand Feature 3. Monitoring Minimal Credit Risks 4. Stress Testing B. Form N-MFP C. Rule 5b-3 D... events; and stress testing.\\20\\ The proposed amendments to rule 2a-7, which are similar to those we...

  10. Planning for compliance: OSHA's bloodborne pathogen rule.

    PubMed

    Bednar, B; Duke, M C

    1990-11-01

    Overall, the bloodborne pathogen rule constitutes a reasonable response to a significant threat to workplace safety. The risks to dialysis workers from HBV and HIV must be minimized or eliminated and the rule is generally consistent with the consensus approach. Unfortunately for dialysis providers, the rule is not exempt from the law of unintended consequences: government regulation will always have impact beyond its object. Promulgation of the final rule will immediately increase the expenses of dialysis providers. Additionally, the enormity of the HBV and HIV problem coupled with the open-ended nature of the rule's key provisions will almost certainly bring additional costs. So long as dialysis reimbursement remains flat, the unintended consequence of the bloodborne pathogen rule may be to quicken the pace of consolidation in the dialysis service market. The added burden of compliance may be too much for small independent facilities. Only large chains may have the resources to comply and survive. To forestall this effect and to provide employees with maximum protection, all dialysis providers should plan now for compliance.

  11. Kinetics of end-to-end collision in short single-stranded nucleic acids.

    PubMed

    Wang, Xiaojuan; Nau, Werner M

    2004-01-28

    A novel fluorescence-based method, which entails contact quenching of the long-lived fluorescent state of 2,3-diazabicyclo[2.2.2]-oct-2-ene (DBO), was employed to measure the kinetics of end-to-end collision in short single-stranded oligodeoxyribonucleotides of the type 5'-DBO-(X)n-dG with X = dA, dC, dT, or dU and n = 2 or 4. The fluorophore was covalently attached to the 5' end and dG was introduced as an efficient intrinsic quencher at the 3' terminus. The end-to-end collision rates, which can be directly related to the efficiency of intramolecular fluorescence quenching, ranged from 0.1 to 9.0 x 10(6) s(-1). They were strongly dependent on the strand length, the base sequence, as well as the temperature. Oligonucleotides containing dA in the backbone displayed much slower collision rates and significantly higher positive activation energies than strands composed of pyrimidine bases, suggesting a higher intrinsic rigidity of oligoadenylate. Comparison of the measured collision rates in short single-stranded oligodeoxyribonucleotides with the previously reported kinetics of hairpin formation indicates that the intramolecular collision is significantly faster than the nucleation step of hairpin closing. This is consistent with the configurational diffusion model suggested by Ansari et al. (Ansari, A.; Kuznetsov, S. V.; Shen, Y. Proc.Natl. Acad. Sci. USA 2001, 98, 7771-7776), in which the formation of misfolded loops is thought to slow hairpin formation.

  12. Influence of capillary end effects on steady-state relative permeability estimates from direct pore-scale simulations

    NASA Astrophysics Data System (ADS)

    Guédon, Gaël Raymond; Hyman, Jeffrey De'Haven; Inzoli, Fabio; Riva, Monica; Guadagnini, Alberto

    2017-12-01

    We investigate and characterize the influence of capillary end effects on steady-state relative permeabilities obtained in pore-scale numerical simulations of two-phase flows. Our study is motivated by the observation that capillary end effects documented in two-phase laboratory-scale experiments can significantly influence permeability estimates. While numerical simulations of two-phase flows in reconstructed pore-spaces are increasingly employed to characterize relative permeabilities, a phenomenon which is akin to capillary end effects can also arise in such analyses due to the constraints applied at the boundaries of the computational domain. We profile the relative strength of these capillary end effects on the calculation of steady-state relative permeabilities obtained within randomly generated porous micro-structures using a finite volume-based two-phase flow solver. We suggest a procedure to estimate the extent of the regions influenced by these capillary end effects, which in turn allows for the alleviation of bias in the estimation of relative permeabilities.

  13. Termination of String Rewriting Rules that have One Pair of Overlaps

    NASA Technical Reports Server (NTRS)

    Geser, Alfons; Bushnell, Dennis M. (Technical Monitor)

    2002-01-01

    This paper presents a partial solution to the long standing open problem of termination of one-rule string rewriting. Overlaps between the two sides of the rule play a central role in existing termination criteria. We characterize termination of all one-rule string rewriting systems that have one such overlap at either end. This both completes a result of Kurth and generalizes a result of Shikishima-Tsuji et al.

  14. Quality of Living and Dying: Pediatric Palliative Care and End-of-Life Decisions in the Netherlands.

    PubMed

    Brouwer, Marije; Maeckelberghe, Els; DE Weerd, Willemien; Verhagen, Eduard

    2018-07-01

    In 2002, The Netherlands continued its leadership in developing rules and jurisdiction regarding euthanasia and end-of-life decisions by implementing the Euthanasia Act, which allows euthanasia for patients 12 years of age and older. Subsequently, in 2005, the regulation on active ending of life for newborns was issued. However, more and more physicians and parents have stated that the age gap between these two regulations-children between 1 and 12 years old-is undesirable. These children should have the same right to end their suffering as adults and newborn infants. An extended debate on pediatric euthanasia ensued, and currently the debate is ongoing as to whether legislation should be altered in order to allow pediatric euthanasia. An emerging major question regards the active ending of life in the context of palliative care: How does a request for active ending of life relate to the care that is given to children in the palliative phase? Until now, the distinction between palliative care and end-of-life decisions continues to remain unclear, making any discussion about their mutual in- and exclusiveness hazardous at best. In this report, therefore, we aim to provide insight into the relationship between pediatric palliative care and end-of-life decisions, as understood in the Netherlands. We do so by first providing an overview of the (legal) rules and regulations regarding euthanasia and active ending of life, followed by an analysis of the relationship between these two, using the Dutch National Guidelines for Palliative Care for Children. The results of this analysis revealed two major and related features of palliative care and end-of-life decisions for children: (1) palliative care and end-of-life decisions are part of the same process, one that focuses both on quality of living and quality of dying, and (2) although physicians are seen as ultimately responsible for making end-of-life decisions, the involvement of parents and children in this decision is

  15. 22 CFR 401.10 - General rule.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true General rule. 401.10 Section 401.10 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE General § 401.10 General rule. The Commission may, at any time, adopt any procedure which it deems expedient and necessary...

  16. Differences in attitudes to end-of-life care among patients, relatives and healthcare professionals

    PubMed Central

    Ang, Guat Cheng; Zhang, Di; Lim, Kim Hwa Jim

    2016-01-01

    INTRODUCTION This study explored and compared the differences in attitudes toward end-of-life care among patients, relatives and healthcare professionals, including doctors and nurses. METHODS We performed a descriptive study on a cross-section of the population of a tertiary hospital in Singapore. Data was collected using a questionnaire survey involving 50 participants from each of the four groups of patients, relatives, doctors and nurses. RESULTS Family members were the most commonly nominated surrogate decision-makers by the patient group (76%) and the majority of the relative group (74%) felt comfortable deciding on end-of-life care for their loved ones. However, the patient and relative groups differed significantly in their preferences on end-of-life care options, including cardiopulmonary resuscitation (CPR) (p = 0.001), intubation (p = 0.003), nasogastric tube feeding (p < 0.001) and the use of antibiotics (p = 0.023). Doctors, nurses and relatives demonstrated differences in preference between end-of-life care for themselves and for their loved ones, especially with regard to the use of nasogastric tube feeding. There was also a difference between patients and doctors in their decisions on CPR (p < 0.001) and intubation (p = 0.008). CONCLUSION This study demonstrated the importance of early planning for end-of-life care. This must be initiated proactively by healthcare professionals to engage patients in a culturally sensitive manner to discuss their preferences, in order to facilitate open communication between the patient and family. PMID:26831313

  17. 76 FR 50117 - Commission Rules and Forms Related to the FASB's Accounting Standards Codification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... [Release Nos. 33-9250; 34-65052; IC-29748] Commission Rules and Forms Related to the FASB's Accounting... Accounting Standards Codification\\TM\\ (``FASB Codification'').\\1\\ The technical amendments include revision... prescribed under the Securities Act, Exchange Act and Investment Company Act. \\1\\ ``FASB Accounting Standards...

  18. End-of-life decisions and the reinvented Rule of Double Effect: a critical analysis.

    PubMed

    Lindblad, Anna; Lynöe, Niels; Juth, Niklas

    2014-09-01

    The Rule of Double Effect (RDE) holds that it may be permissible to harm an individual while acting for the sake of a proportionate good, given that the harm is not an intended means to the good but merely a foreseen side-effect. Although frequently used in medical ethical reasoning, the rule has been repeatedly questioned in the past few decades. However, Daniel Sulmasy, a proponent who has done a lot of work lately defending the RDE, has recently presented a reformulated and more detailed version of the rule. Thanks to its greater precision, this reinvented RDE avoids several problems thought to plague the traditional RDE. Although an improvement compared with the traditional version, we argue that Sulmasy's reinvented RDE will not stand closer scrutiny. Not only has the range of proper applicability narrowed significantly, but, more importantly, Sulmasy fails to establish that there is a morally relevant distinction between intended and foreseen effects. In particular, he fails to establish that there is any distinction that can account for the alleged moral difference between sedation therapy and euthanasia. © 2012 John Wiley & Sons Ltd.

  19. 76 FR 70227 - Medicare Program; End-Stage Renal Disease Prospective Payment System and Quality Incentive...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ...This final rule updates and makes certain revisions to the End-Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2012. We are also finalizing the interim final rule with comment period published on April 6, 2011, regarding the transition budget-neutrality adjustment under the ESRD PPS,. This final rule also sets forth requirements for the ESRD quality incentive program (QIP) for payment years (PYs) 2013 and 2014. In addition, this final rule revises the ambulance fee schedule regulations to conform to statutory changes. This final rule also revises the definition of durable medical equipment (DME) by adding a 3-year minimum lifetime requirement (MLR) that must be met by an item or device in order to be considered durable for the purpose of classifying the item under the Medicare benefit category for DME. Finally, this final rule implements certain provisions of section 154 of the Medicare Improvements for Patients and Providers Act of 2008 (MIPPA) related to the durable medical equipment, prosthetics, orthotics and supplies (DMEPOS) Competitive Acquisition Program and responds to comments received on an interim final rule published January 16, 2009, that implemented these provisions of MIPPA effective April 18, 2009. (See the Table of Contents for a listing of the specific issues addressed in this final rule.)

  20. SU-E-T-109: Development of An End-To-End Test for the Varian TrueBeamtm with a Novel Multiple-Dosimetric Modality H and N Phantom

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zakjevskii, V; Knill, C; Rakowski, J

    2014-06-01

    Purpose: To develop a comprehensive end-to-end test for Varian's TrueBeam linear accelerator for head and neck IMRT using a custom phantom designed to utilize multiple dosimetry devices. Methods: The initial end-to-end test and custom H and N phantom were designed to yield maximum information in anatomical regions significant to H and N plans with respect to: i) geometric accuracy, ii) dosimetric accuracy, and iii) treatment reproducibility. The phantom was designed in collaboration with Integrated Medical Technologies. A CT image was taken with a 1mm slice thickness. The CT was imported into Varian's Eclipse treatment planning system, where OARs and themore » PTV were contoured. A clinical template was used to create an eight field static gantry angle IMRT plan. After optimization, dose was calculated using the Analytic Anisotropic Algorithm with inhomogeneity correction. Plans were delivered with a TrueBeam equipped with a high definition MLC. Preliminary end-to-end results were measured using film and ion chambers. Ion chamber dose measurements were compared to the TPS. Films were analyzed with FilmQAPro using composite gamma index. Results: Film analysis for the initial end-to-end plan with a geometrically simple PTV showed average gamma pass rates >99% with a passing criterion of 3% / 3mm. Film analysis of a plan with a more realistic, ie. complex, PTV yielded pass rates >99% in clinically important regions containing the PTV, spinal cord and parotid glands. Ion chamber measurements were on average within 1.21% of calculated dose for both plans. Conclusion: trials have demonstrated that our end-to-end testing methods provide baseline values for the dosimetric and geometric accuracy of Varian's TrueBeam system.« less

  1. 77 FR 39101 - Rules Relating to Investigations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... procedures for investigations under section 1052 of the Dodd-Frank Act. DATES: The final rule is effective... Federal consumer financial law. Section 1052 of the Dodd-Frank Act sets forth the parameters that govern these investigations. 12 U.S.C. 5562. Section 1052 became effective immediately upon transfer on July 21...

  2. Antievolution Rules Are Unconstitutional.

    ERIC Educational Resources Information Center

    Lewin, Roger

    1984-01-01

    The Texas attorney general has said that this state's textbook antievolution rules violate the First Amendment. Responses and issues related to this statement are discussed. The history of these rules is also discussed. (JN)

  3. New perspective of Grodzins E × B(E2) ↑ product rule

    NASA Astrophysics Data System (ADS)

    Gupta, J. B.; Katoch, Vikas

    In the collective spectra of atomic nuclei, the level energy E(21+) varies with atomic number Z and neutron number N. Also the E2 decay-reduced transition probability B(E2, 01+ → 2 1+) is related to the energy E(21+). The product E(21+) × B(E2) ↑ is constant according to Grodzins product rule, independent of the vibration or rotational status of the nucleus. The product rule is often used for determining B(E2) from the known E(21+). However, the variation of the product with various parameters is also suggested in the literature. Hence, a detailed global study of this rule for (Z = 54‑‑78, 66 < N < 126) region is warranted. We use a novel method of displaying the linear relation of B(E2) ↑ with 1/E(21+) for the isotopes of each element (Xe-Pt), instead of their variation with N,Z or A. Through our work, we firmly establish the global validity of the Grodzins relation of B(E2), being proportional to the moment of inertia, except for the deviation in specific cases. Our B(E2) ↑ versus 1/E plots provide a transparent view of the variation of the low-energy nuclear structure. This gives a new perspective of their nuclear structure. Also the various theoretical interpretations of B(E2)s and the energy E(21+) are reviewed.

  4. A Rule-Based Modeling for the Description of Flexible and Self-healing Business Processes

    NASA Astrophysics Data System (ADS)

    Boukhebouze, Mohamed; Amghar, Youssef; Benharkat, Aïcha-Nabila; Maamar, Zakaria

    In this paper we discuss the importance of ensuring that business processes are label robust and agile at the same time robust and agile. To this end, we consider reviewing the way business processes are managed. For instance we consider offering a flexible way to model processes so that changes in regulations are handled through some self-healing mechanisms. These changes may raise exceptions at run-time if not properly reflected on these processes. To this end we propose a new rule based model that adopts the ECA rules and is built upon formal tools. The business logic of a process can be summarized with a set of rules that implement an organization’s policies. Each business rule is formalized using our ECAPE formalism (Event-Condition-Action-Post condition- post Event). This formalism allows translating a process into a graph of rules that is analyzed in terms of reliably and flexibility.

  5. Some rules for polydimensional squeezing

    NASA Technical Reports Server (NTRS)

    Manko, Vladimir I.

    1994-01-01

    The review of the following results is presented: For mixed state light of N-mode electromagnetic field described by Wigner function which has generic Gaussian form, the photon distribution function is obtained and expressed explicitly in terms of Hermite polynomials of 2N-variables. The momenta of this distribution are calculated and expressed as functions of matrix invariants of the dispersion matrix. The role of new uncertainty relation depending on photon state mixing parameter is elucidated. New sum rules for Hermite polynomials of several variables are found. The photon statistics of polymode even and odd coherent light and squeezed polymode Schroedinger cat light is given explicitly. Photon distribution for polymode squeezed number states expressed in terms of multivariable Hermite polynomials is discussed.

  6. Patient Protection and Affordable Care Act; standards related to essential health benefits, actuarial value and accreditation. Final rule.

    PubMed

    2013-02-25

    This final rule sets forth standards for health insurance issuers consistent with title I of the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act of 2010, referred to collectively as the Affordable Care Act. Specifically, this final rule outlines Exchange and issuer standards related to coverage of essential health benefits and actuarial value. This rule also finalizes a timeline for qualified health plans to be accredited in Federally-facilitated Exchanges and amends regulations providing an application process for the recognition of additional accrediting entities for purposes of certification of qualified health plans.

  7. Playing by the Rules: Instruction and Acculturation in Role-Playing Games

    ERIC Educational Resources Information Center

    Neuenschwander, Bryn

    2008-01-01

    The open-ended, informal, and socially negotiated nature of role-playing games creates a distinct learning challenge for newcomers to the hobby. The explicit rules of the game provide only an incomplete framework for structuring the actions of players, and the expectations and mores of a given group will add other, unspoken rules that discourage…

  8. REVERSALS OF GNEVYSHEV-OHL RULE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tlatov, Andrey G., E-mail: tlatov@mail.ru

    2013-08-01

    We perform an analysis of the number of sunspot groups in activity cycles from 1610 through the present. Here we use the G{sub n} index, which is defined as the average daily number of sunspot groups in cycle n. There is a high positive correlation between the parameter G{sub n} in the current cycle and an analogous parameter in the following cycle G{sub n{sub +1}} both for pairs of even-odd cycles and odd-even activity cycles. In cycle Nos. 10-21 for pairs of even-odd cycles, the ratio of parameter G{sub n} corresponds to the GO rule G{sub n{sub +1}{sup odd}}/G{sub n}{supmore » even}>1. However, during the period {approx}1745-1850, odd cycles were less than the preceding even cycles G{sub n{sub +1}{sup odd}}/G{sub n}{sup even}<1. The ratio of the parameter G{sub n{sub +1}{sup odd}}/G{sub n}{sup even} has a long-term variation within the range 0.5-1.5 with a period of about 21 activity cycles, and it proves the reversal of the GO rule.« less

  9. Medicare program; standards for quality of water used in dialysis and revised guidelines on reuse of hemodialysis filters for end-stage renal disease (ESRD) patients--HCFA. Final rule.

    PubMed

    1995-09-18

    This final rule revises the Medicare conditions for coverage of suppliers of end-stage renal disease services. The revisions remove general language in the regulations regarding water quality; incorporate by reference standards for monitoring the quality of water used in dialysis as published by the Association for the Advancement of Medical Instrumentation (AAMI) in its document, "Hemodialysis Systems" (second edition); and update existing regulations to incorporate by reference the second edition of AAMI's voluntary guidelines on "Reuse of Hemodialyzers."

  10. Update of ESA EEE parts relifing rules

    NASA Astrophysics Data System (ADS)

    Le Blanc, P.; Aicardi, C.

    2002-12-01

    Storage of EEE part represents a key process in space electronics activity. In order to cope with projects time schedule on one hand and with economical procurement constraints on the other hand, parts are often to be stored for quite a long time. Obsolescence issues could make us to build strategic stock in order to be able to still manufacture equipments over time. Up to now several documents ruled the way to de-store (relifed) EEE part in such a way we are able to guaranty their reliability despite their long period of storage. None of these documents backed up their figures and rules with consistent approach and physics. No field return existed or was used to assess these rules. In the frame of a contract from CNES we established an updated rule taking into account field-return and failure mechanisms analysis .We ended up by a new storage and de-storage procedure that is to be included in the ECSS format.

  11. Born’s rule as signature of a superclassical current algebra

    NASA Astrophysics Data System (ADS)

    Fussy, S.; Mesa Pascasio, J.; Schwabl, H.; Grössing, G.

    2014-04-01

    We present a new tool for calculating the interference patterns and particle trajectories of a double-, three- and N-slit system on the basis of an emergent sub-quantum theory developed by our group throughout the last years. The quantum itself is considered as an emergent system representing an off-equilibrium steady state oscillation maintained by a constant throughput of energy provided by a classical zero-point energy field. We introduce the concept of a “relational causality” which allows for evaluating structural interdependences of different systems levels, i.e. in our case of the relations between partial and total probability density currents, respectively. Combined with the application of 21st century classical physics like, e.g., modern nonequilibrium thermodynamics, we thus arrive at a “superclassical” theory. Within this framework, the proposed current algebra directly leads to a new formulation of the guiding equation which is equivalent to the original one of the de Broglie-Bohm theory. By proving the absence of third order interferences in three-path systems it is shown that Born’s rule is a natural consequence of our theory. Considering the series of one-, double-, or, generally, of N-slit systems, with the first appearance of an interference term in the double slit case, we can explain the violation of Sorkin’s first order sum rule, just as the validity of all higher order sum rules. Moreover, the Talbot patterns and Talbot distance for an arbitrary N-slit device can be reproduced exactly by our model without any quantum physics tool.

  12. Kirchhoff's rule for quantum wires

    NASA Astrophysics Data System (ADS)

    Kostrykin, V.; Schrader, R.

    1999-01-01

    We formulate and discuss one-particle quantum scattering theory on an arbitrary finite graph with n open ends and where we define the Hamiltonian to be (minus) the Laplace operator with general boundary conditions at the vertices. This results in a scattering theory with n channels. The corresponding on-shell S-matrix formed by the reflection and transmission amplitudes for incoming plane waves of energy E>0 is given explicitly in terms of the boundary conditions and the lengths of the internal lines. It is shown to be unitary, which may be viewed as the quantum version of Kirchhoff's law. We exhibit covariance and symmetry properties. It is symmetric if the boundary conditions are real. Also there is a duality transformation on the set of boundary conditions and the lengths of the internal lines such that the low-energy behaviour of one theory gives the high-energy behaviour of the transformed theory. Finally, we provide a composition rule by which the on-shell S-matrix of a graph is factorizable in terms of the S-matrices of its subgraphs. All proofs use only known facts from the theory of self-adjoint extensions, standard linear algebra, complex function theory and elementary arguments from the theory of Hermitian symplectic forms.

  13. N Reasons Why Production-Rules are Insufficient Models for Expert System Knowledge Representation Schemes

    DTIC Science & Technology

    1991-02-01

    3 2.2 Hybrid Rule/Fact Schemas .............................................................. 3 3 THE LIMITATIONS OF RULE BASED KNOWLEDGE...or hybrid rule/fact schemas. 2 UNCLASSIFIED .WA UNCLASSIFIED ERL-0520-RR 2.1 Propositional Logic The simplest form of production-rules are based upon...requirements which may lead to poor system performance. 2.2 Hybrid Rule/Fact Schemas Hybrid rule/fact relationships (also known as Predicate Calculus ) have

  14. Bridging the Gap: Solving Spatial Means-Ends Relations in a Locomotor Task

    ERIC Educational Resources Information Center

    Berger, Sarah E.; Adolph, Karen E.; Kavookjian, Alisan E.

    2010-01-01

    Using a means-means-ends problem-solving task, this study examined whether 16-month-old walking infants (N = 28) took into account the width of a bridge as a means for crossing a precipice and the location of a handrail as a means for augmenting balance on a narrow bridge. Infants were encouraged to cross from one platform to another over narrow…

  15. School-aged children after the end of successful treatment of non-central nervous system cancer: longitudinal assessment of health-related quality of life, anxiety and coping.

    PubMed

    Maurice-Stam, H; Oort, F J; Last, B F; Brons, P P T; Caron, H N; Grootenhuis, M A

    2009-07-01

    The aim of the study was to investigate: (1) health-related quality of life (HRQoL) and anxiety in school-aged cancer survivors during the first 4 years of continuous remission after the end of treatment; and (2) correlations of disease-related coping with HRQoL and anxiety. A total of 76 survivors aged 8-15 years completed questionnaires about HRQoL, anxiety and disease-related cognitive coping at one to five measurement occasions. Their HRQoL was compared with norm data, 2 months (n = 49) and 1 year (n = 41), 2 years (n = 41), 3 years (n = 42) and 4 years (n = 27) after treatment. Through longitudinal mixed models analyses it was investigated to what extent disease-related cognitive coping was associated with HRQoL and anxiety over time, independent of the impact of demographic and medical variables. Survivors reported worse Motor Functioning (HRQoL) 2 months after the end of treatment, but from 1 year after treatment they did no longer differ from the norm population. Lower levels of anxiety were associated with male gender, being more optimistic about the further course of the disease (predictive control) and less searching for information about the disease (interpretative control). Stronger reliance on the physician (vicarious control) was associated with better mental HRQoL. As a group, survivors regained good HRQoL from 1 year after treatment. Monitoring and screening survivors are necessary to be able to trace the survivors at risk of worse HRQoL.

  16. 77 FR 477 - Agency Information Collection Activities: Rules Relating to Regulation of Domestic Exchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... comment in response to the notice. This notice solicits comments on rules related to risk disclosure... customers with standard risk disclosure statements concerning the risk of trading commodity interests; and... designation 13.00 2.00 26.00 25.00 650 or self-certification) 33.7--(Risk disclosure) 120.00 115.00 13,800.00...

  17. Nondiscrimination on the basis of handicap; procedures and guidelines relating to health care for handicapped infants--HHS. Final rules.

    PubMed

    1984-01-12

    These are final rules on procedures and guidelines relating to nondiscrimination on the basis of handicap in connection with health care for handicapped infants. These rules are issued under the authority of section 504 of the Rehabilitation Act of 1973, which prohibits discrimination on the basis of handicap in programs and activities receiving Federal financial assistance.

  18. 12 CFR 226.32 - Requirements for certain closed-end home mortgages.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 3 2014-01-01 2014-01-01 false Requirements for certain closed-end home... THE FEDERAL RESERVE SYSTEM (CONTINUED) TRUTH IN LENDING (REGULATION Z) Special Rules for Certain Home Mortgage Transactions § 226.32 Requirements for certain closed-end home mortgages. (a) Coverage. (1) Except...

  19. 8 CFR 103.42 - Rules relating to the Freedom of Information Act (FOIA) and the Privacy Act.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Availability of Records § 103.42 Rules relating to the Freedom of Information Act (FOIA) and the...

  20. 8 CFR 103.42 - Rules relating to the Freedom of Information Act (FOIA) and the Privacy Act.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Availability of Records § 103.42 Rules relating to the Freedom of Information Act (FOIA) and the...

  1. 8 CFR 103.42 - Rules relating to the Freedom of Information Act (FOIA) and the Privacy Act.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION BENEFITS; BIOMETRIC REQUIREMENTS; AVAILABILITY OF RECORDS Availability of Records § 103.42 Rules relating to the Freedom of Information Act (FOIA) and the...

  2. Evolving fuzzy rules for relaxed-criteria negotiation.

    PubMed

    Sim, Kwang Mong

    2008-12-01

    In the literature on automated negotiation, very few negotiation agents are designed with the flexibility to slightly relax their negotiation criteria to reach a consensus more rapidly and with more certainty. Furthermore, these relaxed-criteria negotiation agents were not equipped with the ability to enhance their performance by learning and evolving their relaxed-criteria negotiation rules. The impetus of this work is designing market-driven negotiation agents (MDAs) that not only have the flexibility of relaxing bargaining criteria using fuzzy rules, but can also evolve their structures by learning new relaxed-criteria fuzzy rules to improve their negotiation outcomes as they participate in negotiations in more e-markets. To this end, an evolutionary algorithm for adapting and evolving relaxed-criteria fuzzy rules was developed. Implementing the idea in a testbed, two kinds of experiments for evaluating and comparing EvEMDAs (MDAs with relaxed-criteria rules that are evolved using the evolutionary algorithm) and EMDAs (MDAs with relaxed-criteria rules that are manually constructed) were carried out through stochastic simulations. Empirical results show that: 1) EvEMDAs generally outperformed EMDAs in different types of e-markets and 2) the negotiation outcomes of EvEMDAs generally improved as they negotiated in more e-markets.

  3. 43 CFR 4.801 - Suspension of rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Review Under Part 17 of This Title-Nondiscrimination in Federally Assisted Programs of the Department of... rules. Upon notice to all parties, the responsible Department official or the administrative law judge... determination that no party will be unduly prejudiced and the ends of justice will thereby be served. ...

  4. Final inpatient rehabilitation PPS rule improves on proposed rule.

    PubMed

    Reynolds, M

    2001-10-01

    On August 7, 2001, the Centers for Medicare and Medicaid Services (CMS--formerly HCFA) released the final rule for a new prospective payment system (PPS) for inpatient rehabilitation services describing the process that must be used to receive payment for such services provided to Medicare beneficiaries. The process consists of five steps: First, a clinician performs assessments of the patient upon admission and at discharge. Second, the patient is classified into a case-mix group (CMG) with an assigned relative-value weight within that CMG. Third, the Federal prospective payment rate is determined by multiplying the relative-value weight by an annually updated, budget-neutral conversion factor. Fourth, the Federal prospective payment rate is adjusted to account for facility-specific factors. Finally, the facility-adjusted payment rate may be adjusted for case-specific factors. The final rule eliminates three deficiencies in the proposed rule by providing increased payment for treating any comorbidities documented prior to the second day before discharge, providing more appropriate payment for transfer cases, and minimizing the paperwork associated with patient assessment.

  5. 46 CFR 402.320 - Working rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Vincent, N.Y., dated May 1, 1980, amended to March 24, 1999. (2) The Working Rules and Dispatch Procedures... March 30, 1999. (4) The Working Rules for District No. 3, adopted by the Western Great Lakes Pilots Association, LLP, Superior, WI., dated February 24, 2001 amended to February 28, 2007. (b) [Reserved] [USCG...

  6. Medicare Program; End-Stage Renal Disease Prospective Payment System, Coverage and Payment for Renal Dialysis Services Furnished to Individuals With Acute Kidney Injury, End-Stage Renal Disease Quality Incentive Program, Durable Medical Equipment, Prosthetics, Orthotics and Supplies Competitive Bidding Program Bid Surety Bonds, State Licensure and Appeals Process for Breach of Contract Actions, Durable Medical Equipment, Prosthetics, Orthotics and Supplies Competitive Bidding Program and Fee Schedule Adjustments, Access to Care Issues for Durable Medical Equipment; and the Comprehensive End-Stage Renal Disease Care Model. Final rule.

    PubMed

    2016-11-04

    This rule updates and makes revisions to the End-Stage Renal Disease (ESRD) Prospective Payment System (PPS) for calendar year 2017. It also finalizes policies for coverage and payment for renal dialysis services furnished by an ESRD facility to individuals with acute kidney injury. This rule also sets forth requirements for the ESRD Quality Incentive Program, including the inclusion of new quality measures beginning with payment year (PY) 2020 and provides updates to programmatic policies for the PY 2018 and PY 2019 ESRD QIP. This rule also implements statutory requirements for bid surety bonds and state licensure for the Durable Medical Equipment, Prosthetics, Orthotics, and Supplies (DMEPOS) Competitive Bidding Program (CBP). This rule also expands suppliers' appeal rights in the event of a breach of contract action taken by CMS, by revising the appeals regulation to extend the appeals process to all types of actions taken by CMS for a supplier's breach of contract, rather than limit an appeal for the termination of a competitive bidding contract. The rule also finalizes changes to the methodologies for adjusting fee schedule amounts for DMEPOS using information from CBPs and for submitting bids and establishing single payment amounts under the CBPs for certain groupings of similar items with different features to address price inversions. Final changes also are made to the method for establishing bid limits for items under the DMEPOS CBPs. In addition, this rule summarizes comments on the impacts of coordinating Medicare and Medicaid Durable Medical Equipment for dually eligible beneficiaries. Finally, this rule also summarizes comments received in response to a request for information related to the Comprehensive ESRD Care Model and future payment models affecting renal care.

  7. 77 FR 32593 - Agency Information Collection Activities; Notice of Intent To Renew Collection: Rules Relating To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... Association decisions in disciplinary, membership denial, registration, and member responsibility actions... and disciplinary actions. The Commission estimates the burden of this collection of information as... Renew Collection: Rules Relating To Review of National Futures Association Decisions in Disciplinary...

  8. 12 CFR 1026.32 - Requirements for certain closed-end home mortgages.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Requirements for certain closed-end home... LENDING (REGULATION Z) Special Rules for Certain Home Mortgage Transactions § 1026.32 Requirements for certain closed-end home mortgages. (a) Coverage. (1) Except as provided in paragraph (a)(2) of this...

  9. 12 CFR 226.32 - Requirements for certain closed-end home mortgages.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Requirements for certain closed-end home... THE FEDERAL RESERVE SYSTEM TRUTH IN LENDING (REGULATION Z) Special Rules for Certain Home Mortgage Transactions § 226.32 Requirements for certain closed-end home mortgages. (a) Coverage. (1) Except as provided...

  10. 12 CFR 226.32 - Requirements for certain closed-end home mortgages.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 3 2012-01-01 2012-01-01 false Requirements for certain closed-end home... THE FEDERAL RESERVE SYSTEM TRUTH IN LENDING (REGULATION Z) Special Rules for Certain Home Mortgage Transactions § 226.32 Requirements for certain closed-end home mortgages. (a) Coverage. (1) Except as provided...

  11. 12 CFR 1026.32 - Requirements for certain closed-end home mortgages.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Requirements for certain closed-end home... LENDING (REGULATION Z) Special Rules for Certain Home Mortgage Transactions § 1026.32 Requirements for certain closed-end home mortgages. (a) Coverage. (1) Except as provided in paragraph (a)(2) of this...

  12. New accounting rules: asset allocation and portfolio management.

    PubMed

    Andrew, B K

    1997-01-01

    New accounting rules went into effect at the end of 1995 that are now starting to affect how medical practices must report income from equity and fixed income investments. This article explores the new accounting rules and considers the other factors that help practices determine investment strategies, including desired investment return, comfort with level of risk, appropriate time horizons, liquidity needs and legal restrictions. The author also presents an example that examines the different considerations that may affect an asset allocation decision, including endowments and operating reserve funds.

  13. 17 CFR 239.15A - Form N-1A, registration statement of open-end management investment companies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... statement of open-end management investment companies. 239.15A Section 239.15A Commodity and Securities... Registration Statements § 239.15A Form N-1A, registration statement of open-end management investment companies... management investment companies other than separate accounts of insurance companies registered under the...

  14. 76 FR 61282 - Defense Federal Acquisition Regulation Supplement; Definition of “Qualifying Country End Product...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... Federal Acquisition Regulation Supplement; Definition of ``Qualifying Country End Product'' (DFARS Case... Supplement (DFARS) to revise the definition of ``qualifying country end product.'' This final rule eliminates the component test for qualifying country end products that are commercially available off-the-shelf...

  15. New Rule Use Drives the Relation between Working Memory Capacity and Raven's Advanced Progressive Matrices

    ERIC Educational Resources Information Center

    Wiley, Jennifer; Jarosz, Andrew F.; Cushen, Patrick J.; Colflesh, Gregory J. H.

    2011-01-01

    The correlation between individual differences in working memory capacity and performance on the Raven's Advanced Progressive Matrices (RAPM) is well documented yet poorly understood. The present work proposes a new explanation: that the need to use a new combination of rules on RAPM problems drives the relation between performance and working…

  16. 26 CFR 1.381(a)-1 - General rule relating to carryovers in certain corporate acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... corporate acquisitions. 1.381(a)-1 Section 1.381(a)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT... Reorganizations § 1.381(a)-1 General rule relating to carryovers in certain corporate acquisitions. (a) Allowance... change in identity, form, or place of organization qualifying under section 368(a)(1)(F). (2) Acquiring...

  17. 26 CFR 1.381(a)-1 - General rule relating to carryovers in certain corporate acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... corporate acquisitions. 1.381(a)-1 Section 1.381(a)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT... Reorganizations § 1.381(a)-1 General rule relating to carryovers in certain corporate acquisitions. (a) Allowance... change in identity, form, or place of organization qualifying under section 368(a)(1)(F). (2) Acquiring...

  18. 26 CFR 1.381(a)-1 - General rule relating to carryovers in certain corporate acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... corporate acquisitions. 1.381(a)-1 Section 1.381(a)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT... Reorganizations § 1.381(a)-1 General rule relating to carryovers in certain corporate acquisitions. (a) Allowance... change in identity, form, or place of organization qualifying under section 368(a)(1)(F). (2) Acquiring...

  19. Choosing the Rules: Distinct and Overlapping Frontoparietal Representations of Task Rules for Perceptual Decisions

    PubMed Central

    Kriegeskorte, Nikolaus; Carlin, Johan D.; Rowe, James B.

    2013-01-01

    Behavior is governed by rules that associate stimuli with responses and outcomes. Human and monkey studies have shown that rule-specific information is widely represented in the frontoparietal cortex. However, it is not known how establishing a rule under different contexts affects its neural representation. Here, we use event-related functional MRI (fMRI) and multivoxel pattern classification methods to investigate the human brain's mechanisms of establishing and maintaining rules for multiple perceptual decision tasks. Rules were either chosen by participants or specifically instructed to them, and the fMRI activation patterns representing rule-specific information were compared between these contexts. We show that frontoparietal regions differ in the properties of their rule representations during active maintenance before execution. First, rule-specific information maintained in the dorsolateral and medial frontal cortex depends on the context in which it was established (chosen vs specified). Second, rule representations maintained in the ventrolateral frontal and parietal cortex are independent of the context in which they were established. Furthermore, we found that the rule-specific coding maintained in anticipation of stimuli may change with execution of the rule: representations in context-independent regions remain invariant from maintenance to execution stages, whereas rule representations in context-dependent regions do not generalize to execution stage. The identification of distinct frontoparietal systems with context-independent and context-dependent task rule representations, and the distinction between anticipatory and executive rule representations, provide new insights into the functional architecture of goal-directed behavior. PMID:23864675

  20. False Position, Double False Position and Cramer's Rule

    ERIC Educational Resources Information Center

    Boman, Eugene

    2009-01-01

    We state and prove the methods of False Position (Regula Falsa) and Double False Position (Regula Duorum Falsorum). The history of both is traced from ancient Egypt and China through the work of Fibonacci, ending with a connection between Double False Position and Cramer's Rule.

  1. 17 CFR 230.498 - Summary Prospectuses for open-end management investment companies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-end management investment companies. 230.498 Section 230.498 Commodity and Securities Exchanges... management investment companies. (a) Definitions. For purposes of this section: (1) Class means a class of... reliance on an exemptive rule adopted by the Commission. (3) Fund means an open-end management investment...

  2. Power and politics in international funding for reproductive health: the US Global Gag Rule.

    PubMed

    Crane, Barbara B; Dusenberry, Jennifer

    2004-11-01

    Since 2001, the US government has used its power as a leading donor to family planning programmes to pursue policies in conflict with global agreements on reproductive rights. Prominent among these policies is the Mexico City Policy (or Global Gag Rule), which restricts non-governmental organisations (NGOs) in developing countries that receive USAID family planning funding from engaging in most abortion-related activities, even with their own funds. This paper reviews the history and political origins of the Gag Rule under several Republican party presidents. The Gag Rule has not achieved an overall reduction in abortions; rather, where it has disrupted family planning services, the policy is more likely to have increased the number of abortions. This paper concludes that the Gag Rule is a radical intrusion on the rights and autonomy of recipients of US funding. Regardless of whether or not it is rescinded in the future, the underlying issues in the politics of US reproductive health assistance are likely to persist. NGOs that wish to free themselves from the constraints it imposes must find the means to end their dependence on USAID funding, including turning to other donors. NGOs should also take the lead in opposing policies such as the Gag Rule that violate global agreements.

  3. 29 CFR 102.123 - Amendment or rescission of rules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 2 2012-07-01 2012-07-01 false Amendment or rescission of rules. 102.123 Section 102.123 Labor Regulations Relating to Labor NATIONAL LABOR RELATIONS BOARD RULES AND REGULATIONS, SERIES 8... of rules. Any rule or regulation may be amended or rescinded by the Board at any time. ...

  4. 29 CFR 102.123 - Amendment or rescission of rules.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 2 2014-07-01 2014-07-01 false Amendment or rescission of rules. 102.123 Section 102.123 Labor Regulations Relating to Labor NATIONAL LABOR RELATIONS BOARD RULES AND REGULATIONS, SERIES 8... of rules. Any rule or regulation may be amended or rescinded by the Board at any time. ...

  5. 29 CFR 102.123 - Amendment or rescission of rules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Amendment or rescission of rules. 102.123 Section 102.123 Labor Regulations Relating to Labor NATIONAL LABOR RELATIONS BOARD RULES AND REGULATIONS, SERIES 8... of rules. Any rule or regulation may be amended or rescinded by the Board at any time. ...

  6. 29 CFR 102.123 - Amendment or rescission of rules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 2 2013-07-01 2013-07-01 false Amendment or rescission of rules. 102.123 Section 102.123 Labor Regulations Relating to Labor NATIONAL LABOR RELATIONS BOARD RULES AND REGULATIONS, SERIES 8... of rules. Any rule or regulation may be amended or rescinded by the Board at any time. ...

  7. 29 CFR 102.123 - Amendment or rescission of rules.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Amendment or rescission of rules. 102.123 Section 102.123 Labor Regulations Relating to Labor NATIONAL LABOR RELATIONS BOARD RULES AND REGULATIONS, SERIES 8... of rules. Any rule or regulation may be amended or rescinded by the Board at any time. ...

  8. Triplet Transport to and Trapping by Acceptor End Groups on Conjugated Polyfluorene Chains

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sreearunothai, P.; Miller, J.; Estrada, A.

    2011-08-31

    Triplet excited states created in polyfluorene (pF) molecules having average lengths up to 170 repeat units were transported to and captured by trap groups at the ends in less {approx}40 ns. Almost all of the triplets attached to the chains reached the trap groups, ruling out the presence of substantial numbers of defects that prevent transport. The transport yields a diffusion coefficient D of at least 3 x 10{sup -4} cm{sup 2} s{sup -1}, which is 30 times typical molecular diffusion and close to a value for triplet transport reported by Keller (J. Am. Chem. Soc.2011, 133, 11289-11298). The tripletmore » states were created in solution by pulse radiolysis; time resolution was limited by the rate of attachment of triplets to the pF chains. Naphthylimide (NI) or anthraquinone (AQ) groups attached to the ends of the chains acted as traps for the triplets, although AQ would not have been expected to serve as a trap on the basis of triplet energies of the separate molecules. The depths of the NI and AQ triplet traps were determined by intermolecular triplet transfer equilibria and temperature dependence. The trap depths are shallow, just a few times thermal energy for both, so a small fraction of the triplets reside in the pF chains in equilibrium with the end-trapped triplets. Trapping by AQ appears to arise from charge transfer interactions between the pF chains and the electron-accepting AQ groups. Absorption bands of the end-trapped triplet states are similar in peak wavelength (760 nm) and shape to the 760 nm bands of triplets in the pF chains but have reduced intensities. When an electron donor, N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD), is added to the solution, it reacts with the end-trapped triplets to remove the 760 nm bands and to make the trapping irreversible. New bands created upon reaction with TMPD may be due to charge transfer states.« less

  9. 26 CFR 1.381(a)-1 - General rule relating to carryovers in certain corporate acquisitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... corporate acquisitions. 1.381(a)-1 Section 1.381(a)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT...)-1 General rule relating to carryovers in certain corporate acquisitions. (a) Allowance of carryovers... requirements of section 354(b)(1)(A) and (B) are satisfied; and (v) A mere change in identity, form, or place...

  10. 26 CFR 1.381(a)-1 - General rule relating to carryovers in certain corporate acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... corporate acquisitions. 1.381(a)-1 Section 1.381(a)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT...)-1 General rule relating to carryovers in certain corporate acquisitions. (a) Allowance of carryovers... requirements of section 354(b)(1)(A) and (B) are satisfied; and (v) A mere change in identity, form, or place...

  11. Cancer Rehabilitation: Do Functional Gains Relate to 60 Percent Rule Classification or to the Presence of Metastasis?

    PubMed

    Sliwa, James A; Shahpar, Samman; Huang, Mark E; Spill, Gayle; Semik, Patrick

    2016-02-01

    Literature supporting the benefits of inpatient rehabilitation for cancer patients is increasing. Many cancer patients, however, do not qualify for inclusion in the Centers for Medicare and Medicaid 60% rule and consequently may not receive services. The benefit of inpatient rehabilitation in this specific cancer group has not been investigated and is the focus of this study. To investigate functional gains made during inpatient rehabilitation by patients impaired by cancer, and to compare the functional gains made during inpatient rehabilitation for patients impaired by cancer in relation to the presence or absence of metastatic disease and compliance or noncompliance with the Medicare 60% rule. Freestanding university-affiliated rehabilitation hospital. A total of 176 adult patients admitted for inpatient rehabilitation due to cancer. Retrospective chart review of patients admitted for inpatient rehabilitation with deficits identified related to cancer. Demographic data including cancer type, presence of metastasis, age, gender, marital status, ethnicity, length of stay (LOS), discharge destination, and transfer to acute care. Functional status including admission and discharge Functional Independence Measure Score (FIM), total, motor, and cognitive FIM gains, total, motor, and cognitive FIM efficiency for the study sample, for patients with and without a diagnosis compliant with the 60% rule and for patients with and without metastatic disease. In all, 176 cases met inclusion criteria. An admission coded diagnosis that was compliant with the 60% rule was present in 97 cases (55.1%). In 153 cases, the presence or absence of metastatic disease was known. Metastatic disease was present in 69 cases (45%). All groups (total sample, metastatic versus nonmetastatic, compliant versus noncompliant) made significant functional gains. Patients with a diagnosis noncompliant with the 60% rule had higher admission total FIM (P = .001), discharge total FIM (P = .014

  12. Statistical Rules-of-Thumb.

    ERIC Educational Resources Information Center

    Brewer, James K.

    1988-01-01

    Six best-selling introductory behavioral statistics textbooks that were published in 1982 and two well-known sampling theory textbooks were reviewed to determine the presence of rules-of-thumb--useful principles with wide application that are not intended to be strictly accurate. The relative frequency and type of rules are reported along with a…

  13. End-group-functionalized poly(N,N-diethylacrylamide) via free-radical chain transfer polymerization: Influence of sulfur oxidation and cyclodextrin on self-organization and cloud points in water

    PubMed Central

    Reinelt, Sebastian; Steinke, Daniel

    2014-01-01

    Summary In this work we report the synthesis of thermo-, oxidation- and cyclodextrin- (CD) responsive end-group-functionalized polymers, based on N,N-diethylacrylamide (DEAAm). In a classical free-radical chain transfer polymerization, using thiol-functionalized 4-alkylphenols, namely 3-(4-(1,1-dimethylethan-1-yl)phenoxy)propane-1-thiol and 3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)propane-1-thiol, poly(N,N-diethylacrylamide) (PDEAAm) with well-defined hydrophobic end-groups is obtained. These end-group-functionalized polymers show different cloud point values, depending on the degree of polymerization and the presence of randomly methylated β-cyclodextrin (RAMEB-CD). Additionally, the influence of the oxidation of the incorporated thioether linkages on the cloud point is investigated. The resulting hydrophilic sulfoxides show higher cloud point values for the lower critical solution temperature (LCST). A high degree of functionalization is supported by 1H NMR-, SEC-, FTIR- and MALDI–TOF measurements. PMID:24778720

  14. Non-lightlike ruled surfaces with constant curvatures in Minkowski 3-space

    NASA Astrophysics Data System (ADS)

    Ali, Ahmad Tawfik

    We study the non-lightlike ruled surfaces in Minkowski 3-space with non-lightlike base curve c(s) =∫(αt + βn + γb)ds, where t, n, b are the tangent, principal normal and binormal vectors of an arbitrary timelike curve Γ(s). Some important results of flat, minimal, II-minimal and II-flat non-lightlike ruled surfaces are studied. Finally, the following interesting theorem is proved: the only non-zero constant mean curvature (CMC) non-lightlike ruled surface is developable timelike ruled surface generated by binormal vector.

  15. Sum Rule for a Schiff-Like Dipole Moment

    NASA Astrophysics Data System (ADS)

    Raduta, A. A.; Budaca, R.

    The energy-weighted sum rule for an electric dipole transition operator of a Schiff type differs from the Thomas-Reiche-Kuhn (TRK) sum rule by several corrective terms which depend on the number of system components, N. For illustration the formalism was applied to the case of Na clusters. One concludes that the random phase approximation (RPA) results for Na clusters obey the modified TRK sum rule.

  16. Drinking Water Arsenic Rule History

    EPA Pesticide Factsheets

    The EPA published the final arsenic rule on January 22, 2001. In response to the national debate surrounding the arsenic rule related to science and costs, the EPA announced on March 20, 2001 that the agency would reassess the science and cost issues.

  17. 14 CFR 133.33 - Operating rules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Operating rules. 133.33 Section 133.33... OPERATIONS Operating Rules and Related Requirements § 133.33 Operating rules. (a) No person may conduct a... prescribed in § 133.47. (b) No person may conduct a rotorcraft external-load operation unless— (1) The...

  18. 76 FR 17071 - Amendment of the Commission's Rules Related to Retransmission Consent

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... retransmission consent negotiations. The Commission believes that these rule changes could allow the market-based negotiations contemplated by the statute to proceed more smoothly, provide greater certainty to the negotiating... streamline and clarify our rules concerning or affecting retransmission consent negotiations. Our primary...

  19. Comprehensive Child Welfare Information System. Final rule.

    PubMed

    2016-06-02

    This final rule replaces the Statewide and Tribal Automated Child Welfare Information Systems (S/TACWIS) rule with the Comprehensive Child Welfare Information System (CCWIS) rule. The rule also makes conforming amendments in rules in related requirements. This rule will assist title IV-E agencies in developing information management systems that leverage new innovations and technology in order to better serve children and families. More specifically, this final rule supports the use of cost-effective, innovative technologies to automate the collection of high-quality case management data and to promote its analysis, distribution, and use by workers, supervisors, administrators, researchers, and policy makers.

  20. Validity of Vegard’s rule for Al1-xInxN (0.08  <  x  <  0.28) thin films grown on GaN templates

    NASA Astrophysics Data System (ADS)

    Magalhães, S.; Franco, N.; Watson, I. M.; Martin, R. W.; O'Donnell, K. P.; Schenk, H. P. D.; Tang, F.; Sadler, T. C.; Kappers, M. J.; Oliver, R. A.; Monteiro, T.; Martin, T. L.; Bagot, P. A. J.; Moody, M. P.; Alves, E.; Lorenz, K.

    2017-05-01

    In this work, comparative x-ray diffraction (XRD) and Rutherford backscattering spectrometry (RBS) measurements allow a comprehensive characterization of Al1-xInxN thin films grown on GaN. Within the limits of experimental accuracy, and in the compositional range 0.08  <  x  <  0.28, the lattice parameters of the alloys generally obey Vegard’s rule, varying linearly with the InN fraction. Results are also consistent with the small deviation from linear behaviour suggested by Darakchieva et al (2008 Appl. Phys. Lett. 93 261908). However, unintentional incorporation of Ga, revealed by atom probe tomography (APT) at levels below the detection limit for RBS, may also affect the lattice parameters. Furthermore, in certain samples the compositions determined by XRD and RBS differ significantly. This fact, which was interpreted in earlier publications as an indication of a deviation from Vegard’s rule, may rather be ascribed to the influence of defects or impurities on the lattice parameters of the alloy. The wide-ranging set of Al1-xInxN films studied allowed furthermore a detailed investigation of the composition leading to lattice-matching of Al1-xInxN/GaN bilayers.

  1. Specific end-to-end attachment of chromosomes in Ornithogalum virens.

    PubMed

    Ashley, T

    1979-08-01

    C-banding of nonhomologous chromosomes in haploid generative nuclei of Ornithogalum virens (n = 3) reveals a high degree of specificity with respect to end-to-end connexions. The centromeric end of chromosome 2 preferentially associates with the centromeric end of chromosome 3 and the telomeric end of chromosome 3 associates preferentially with the telomeric end of chromosome 1. This same association of nonhomologous chromosomes persists in prophase nuclei of diploid root tips. In addition, the telomeric ends of the 2 chromosome 2s are connected to one another as are the centromeric ends of the chromosome 1s. This results in a ring of chromosomes in which homologues lie opposite one another. Centromeric ends lie on one side of the nucleus and telomeric ends on the other. It is proposed that this specific association of chromosome ends reflects an order which was probably established at the preceding anaphase or telophase and which persists throughout interphase. The suggestion is made that the proximity of homologous ends and consequently homologous alignment may facilitate initiation of pairing at meiosis.

  2. Bayesian probability estimates are not necessary to make choices satisfying Bayes' rule in elementary situations.

    PubMed

    Domurat, Artur; Kowalczuk, Olga; Idzikowska, Katarzyna; Borzymowska, Zuzanna; Nowak-Przygodzka, Marta

    2015-01-01

    This paper has two aims. First, we investigate how often people make choices conforming to Bayes' rule when natural sampling is applied. Second, we show that using Bayes' rule is not necessary to make choices satisfying Bayes' rule. Simpler methods, even fallacious heuristics, might prescribe correct choices reasonably often under specific circumstances. We considered elementary situations with binary sets of hypotheses and data. We adopted an ecological approach and prepared two-stage computer tasks resembling natural sampling. Probabilistic relations were inferred from a set of pictures, followed by a choice which was made to maximize the chance of a preferred outcome. Use of Bayes' rule was deduced indirectly from choices. Study 1 used a stratified sample of N = 60 participants equally distributed with regard to gender and type of education (humanities vs. pure sciences). Choices satisfying Bayes' rule were dominant. To investigate ways of making choices more directly, we replicated Study 1, adding a task with a verbal report. In Study 2 (N = 76) choices conforming to Bayes' rule dominated again. However, the verbal reports revealed use of a new, non-inverse rule, which always renders correct choices, but is easier than Bayes' rule to apply. It does not require inversion of conditions [transforming P(H) and P(D|H) into P(H|D)] when computing chances. Study 3 examined the efficiency of three fallacious heuristics (pre-Bayesian, representativeness, and evidence-only) in producing choices concordant with Bayes' rule. Computer-simulated scenarios revealed that the heuristics produced correct choices reasonably often under specific base rates and likelihood ratios. Summing up we conclude that natural sampling results in most choices conforming to Bayes' rule. However, people tend to replace Bayes' rule with simpler methods, and even use of fallacious heuristics may be satisfactorily efficient.

  3. Bayesian probability estimates are not necessary to make choices satisfying Bayes’ rule in elementary situations

    PubMed Central

    Domurat, Artur; Kowalczuk, Olga; Idzikowska, Katarzyna; Borzymowska, Zuzanna; Nowak-Przygodzka, Marta

    2015-01-01

    This paper has two aims. First, we investigate how often people make choices conforming to Bayes’ rule when natural sampling is applied. Second, we show that using Bayes’ rule is not necessary to make choices satisfying Bayes’ rule. Simpler methods, even fallacious heuristics, might prescribe correct choices reasonably often under specific circumstances. We considered elementary situations with binary sets of hypotheses and data. We adopted an ecological approach and prepared two-stage computer tasks resembling natural sampling. Probabilistic relations were inferred from a set of pictures, followed by a choice which was made to maximize the chance of a preferred outcome. Use of Bayes’ rule was deduced indirectly from choices. Study 1 used a stratified sample of N = 60 participants equally distributed with regard to gender and type of education (humanities vs. pure sciences). Choices satisfying Bayes’ rule were dominant. To investigate ways of making choices more directly, we replicated Study 1, adding a task with a verbal report. In Study 2 (N = 76) choices conforming to Bayes’ rule dominated again. However, the verbal reports revealed use of a new, non-inverse rule, which always renders correct choices, but is easier than Bayes’ rule to apply. It does not require inversion of conditions [transforming P(H) and P(D|H) into P(H|D)] when computing chances. Study 3 examined the efficiency of three fallacious heuristics (pre-Bayesian, representativeness, and evidence-only) in producing choices concordant with Bayes’ rule. Computer-simulated scenarios revealed that the heuristics produced correct choices reasonably often under specific base rates and likelihood ratios. Summing up we conclude that natural sampling results in most choices conforming to Bayes’ rule. However, people tend to replace Bayes’ rule with simpler methods, and even use of fallacious heuristics may be satisfactorily efficient. PMID:26347676

  4. 78 FR 31993 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Order Approving Proposed Rule Change Relating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-69607; File No. SR-BX-2013-029] Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Order Approving Proposed Rule Change Relating to Board of Director Qualifications May 20, 2013. On March 27, 2013, NASDAQ OMX BX, Inc. (``BX'' or ``Exchange'') filed with the...

  5. 75 FR 62462 - Additions to the List of Validated End-Users in the People's Republic of China: Hynix...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ...In this final rule, the Bureau of Industry and Security amends the Export Administration Regulations (EAR) to add three end-users, Hynix Semiconductor (China) Ltd., Hynix Semiconductor (Wuxi) Ltd. and Lam Research Corporation to the list of validated end-users in the People's Republic of China (PRC). With this rule, exports, reexports and transfers (in-country) of certain items to one facility of Hynix Semiconductor (China) Ltd., one facility of Hynix Semiconductor (Wuxi) Ltd. and nine facilities of Lam Research Corporation in the PRC are now authorized under Authorization Validated End-User (VEU).

  6. Reimagining the learned intermediary rule for the new pharmaceutical marketplace.

    PubMed

    Hall, Timothy S

    2004-01-01

    For the past decade, the learned intermediary rule--the rule of tort law that provides that drug manufacturers may satisfy their duty to warn of a drug's dangers by warning the prescribing physician rather than the end user of the drug--has been the subject of vigorous academic debate. That debate has been largely moot, however, as the courts have proven reluctant to make significant inroads on the protection offered by the Rule to drug manufacturers. This Article proposes a new approach to the Rule. Part I discusses the history and overwhelming adoption of the Rule pursuant to the Restatement (Second) of Torts. Part II argues that changes in the health care delivery system have resulted in a legal system that introduces market distortions by effectively immunizing the pharmaceutical industry from the legal and social consequences of its own actions. Part III then sets forth a reconceptualization of the Rule, which preserves the Rule's benefits with respect to the drug industry, the health care system, and the goals of tort law, while also strengthening the protection the tort system offers to individuals injured by prescription drugs.

  7. Can Baird's and Clar's Rules Combined Explain Triplet State Energies of Polycyclic Conjugated Hydrocarbons with Fused 4nπ- and (4n + 2)π-Rings?

    PubMed

    Ayub, Rabia; Bakouri, Ouissam El; Jorner, Kjell; Solà, Miquel; Ottosson, Henrik

    2017-06-16

    Compounds that can be labeled as "aromatic chameleons" are π-conjugated compounds that are able to adjust their π-electron distributions so as to comply with the different rules of aromaticity in different electronic states. We used quantum chemical calculations to explore how the fusion of benzene rings onto aromatic chameleonic units represented by biphenylene, dibenzocyclooctatetraene, and dibenzo[a,e]pentalene modifies the first triplet excited states (T 1 ) of the compounds. Decreases in T 1 energies are observed when going from isomers with linear connectivity of the fused benzene rings to those with cis- or trans-bent connectivities. The T 1 energies decreased down to those of the parent (isolated) 4nπ-electron units. Simultaneously, we observe an increased influence of triplet state aromaticity of the central 4n ring as given by Baird's rule and evidenced by geometric, magnetic, and electron density based aromaticity indices (HOMA, NICS-XY, ACID, and FLU). Because of an influence of triplet state aromaticity in the central 4nπ-electron units, the most stabilized compounds retain the triplet excitation in Baird π-quartets or octets, enabling the outer benzene rings to adapt closed-shell singlet Clar π-sextet character. Interestingly, the T 1 energies go down as the total number of aromatic cycles within a molecule in the T 1 state increases.

  8. Exact sum rules for inhomogeneous strings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Amore, Paolo, E-mail: paolo.amore@gmail.com

    2013-11-15

    We derive explicit expressions for the sum rules of the eigenvalues of inhomogeneous strings with arbitrary density and with different boundary conditions. We show that the sum rule of order N may be obtained in terms of a diagrammatic expansion, with (N−1)!/2 independent diagrams. These sum rules are used to derive upper and lower bounds to the energy of the fundamental mode of an inhomogeneous string; we also show that it is possible to improve these approximations taking into account the asymptotic behavior of the spectrum and applying the Shanks transformation to the sequence of approximations obtained to the differentmore » orders. We discuss three applications of these results. -- Highlights: •We derive an explicit expression for the sum rules of an inhomogeneous string. •We obtain a diagrammatic representation for the sum rules of a given order. •We obtain precise bounds on the lowest eigenvalue of the string.« less

  9. Simplification rules for birdtrack operators

    NASA Astrophysics Data System (ADS)

    Alcock-Zeilinger, J.; Weigert, H.

    2017-05-01

    This paper derives a set of easy-to-use tools designed to simplify calculations with birdtrack operators comprised of symmetrizers and antisymmetrizers. In particular, we present cancellation rules allowing one to shorten the birdtrack expressions of operators and propagation rules identifying the circumstances under which it is possible to propagate symmetrizers past antisymmetrizers and vice versa. We exhibit the power of these simplification rules by means of a short example in which we apply the tools derived in this paper on a typical operator that can be encountered in the representation theory of 𝖲𝖴 (N ) over the product space V⊗m. These rules form the basis for the construction of compact Hermitian Young projection operators and their transition operators addressed in companion papers [J. Alcock-Zeilinger and H. Weigert, "Compact Hermitian Young projection operators," e-print arXiv:1610.10088 [math-ph] and J. Alcock-Zeilinger and H. Weigert, "Transition operators," e-print arXiv:1610.08802 [math-ph

  10. 77 FR 40951 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ...This rule proposes to update and make revisions to the End- Stage Renal Disease (ESRD) prospective payment system (PPS) for calendar year (CY) 2013. This rule also proposes to set forth requirements for the ESRD quality incentive program (QIP), including for payment year (PY) 2015 and beyond. This proposed rule will implement changes to bad debt reimbursement for all Medicare providers, suppliers, and other entities eligible to receive bad debt. (See the Table of Contents for a listing of the specific issues addressed in this proposed rule.)

  11. Young Children's Understanding of Beliefs about Moral and Conventional Rule Violations

    ERIC Educational Resources Information Center

    Conry-Murray, Clare

    2013-01-01

    Children of ages 3-5 ("N" = 62) were assessed by using standard theory-of-mind tasks and unusual belief tasks related to false information and beliefs endorsing violations of moral (welfare and fairness) and social conventional (school rules) domains. Younger children (under 5 years) did not accurately attribute unusual factual beliefs…

  12. Optical Thomas-Reiche-Kuhn sum rules.

    PubMed

    Barnett, Stephen M; Loudon, Rodney

    2012-01-06

    The Thomas-Reiche-Kuhn sum rule is a fundamental consequence of the position-momentum commutation relation for an atomic electron and it provides an important constraint on the transition matrix elements for an atom. Analogously, the commutation relations for the electromagnetic field operators in a magnetodielectric medium constrain the properties of the dispersion relations for the medium through four sum rules for the allowed phase and group velocities for polaritons propagating through the medium. These rules apply to all bulk media including the metamaterials designed to provide negative refractive indices. An immediate consequence of this is that it is not possible to construct a medium in which all the polariton modes for a given wavelength lie in the negative-index region.

  13. Optical Thomas-Reiche-Kuhn Sum Rules

    NASA Astrophysics Data System (ADS)

    Barnett, Stephen M.; Loudon, Rodney

    2012-01-01

    The Thomas-Reiche-Kuhn sum rule is a fundamental consequence of the position-momentum commutation relation for an atomic electron and it provides an important constraint on the transition matrix elements for an atom. Analogously, the commutation relations for the electromagnetic field operators in a magnetodielectric medium constrain the properties of the dispersion relations for the medium through four sum rules for the allowed phase and group velocities for polaritons propagating through the medium. These rules apply to all bulk media including the metamaterials designed to provide negative refractive indices. An immediate consequence of this is that it is not possible to construct a medium in which all the polariton modes for a given wavelength lie in the negative-index region.

  14. Effortful control mediates relations between children's attachment security and their regard for rules of conduct

    PubMed Central

    Nordling, Jamie Koenig; Boldt, Lea J.; O'Bleness, Jessica; Kochanska, Grazyna

    2015-01-01

    Although attachment security has been associated with children's rule-compatible conduct, the mechanism through which attachment influences early regard for rules is not well established. We hypothesized that effortful control would mediate the link between security and indicators of children's emerging regard for rules (discomfort following rule violations, internalization of parents' and experimenter's rules, few externalizing behaviors). In a longitudinal study, the Attachment Q-Set was completed by parents, effortful control was observed, and Regard for Rules was observed and rated by parents. The proposed model fit the data well: Children's security to mothers predicted their effortful control, which in turn had a direct link to a greater Regard for Rules. Children's security with fathers did not predict effortful control. The mother-child relationship appears particularly important for positive developmental cascades of self-regulation and socialization. PMID:27158193

  15. 16 CFR 1025.1 - Scope of rules.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Constitutional due process rights of all parties. It is anticipated that in any adjudicative proceedings for the... PROCEEDINGS Scope of Rules, Nature of Adjudicative Proceedings, Definitions § 1025.1 Scope of rules. The rules in this part govern procedures in adjudicative proceedings relating to the provisions of section 15...

  16. 26 CFR 1.6664-1 - Accuracy-related and fraud penalties; definitions, effective date and special rules.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Additions to the Tax... definition of “underpayment” of income taxes imposed under subtitle A is set forth in § 1.6664-2. Ordering rules for computing the total amount of accuracy-related and fraud penalties imposed with respect to a...

  17. 22 CFR 42.12 - Rules of chargeability.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Rules of chargeability. 42.12 Section 42.12 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Classification and Foreign State Chargeability § 42.12 Rules of chargeability. (a...

  18. 22 CFR 42.12 - Rules of chargeability.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Rules of chargeability. 42.12 Section 42.12 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Classification and Foreign State Chargeability § 42.12 Rules of chargeability. (a...

  19. 22 CFR 42.12 - Rules of chargeability.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Rules of chargeability. 42.12 Section 42.12 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Classification and Foreign State Chargeability § 42.12 Rules of chargeability. (a...

  20. 22 CFR 42.12 - Rules of chargeability.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Rules of chargeability. 42.12 Section 42.12 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Classification and Foreign State Chargeability § 42.12 Rules of chargeability. (a...

  1. 75 FR 70159 - Group Health Plans and Health Insurance Coverage Rules Relating to Status as a Grandfathered...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... Group Health Plans and Health Insurance Coverage Rules Relating to Status as a Grandfathered Health Plan... contracts of insurance. The temporary regulations provide guidance to employers, group health plans, and health insurance issuers providing group health insurance coverage. The IRS is issuing the temporary...

  2. Relating Paleoclimate Data and Past Temperature Gradients: Some Suggestive Rules

    NASA Technical Reports Server (NTRS)

    Rind, David

    1999-01-01

    Understanding tropical sensitivity is perhaps the major concern confronting researchers, for both past and future climate change issues. Tropical data has been beset by contradictions, and many techniques applicable to the extratropics are either unavailable or fraught with uncertainty when applied at low latitudes. Paleoclimate data, if interpreted within the context of the latitudinal temperature gradient data they imply, can be used to estimate what happened to tropical temperatures in the past, and provide a first guess for what might happen in the future. The approach is made possible by the modeling result that atmospheric dynamical changes, and the climate impacts they produce, respond primarily to temperature gradient changes. Here we review some "rules" obtained from GCM (General Circulation Model) experiments with different sea surface temperature gradients and different forcing, that can be used to relate paleoclimate reconstructions to the likely temperature gradient changes they suggest.

  3. 22 CFR 401.9 - Suspension or amendment of rules.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Suspension or amendment of rules. 401.9 Section 401.9 Foreign Relations INTERNATIONAL JOINT COMMISSION, UNITED STATES AND CANADA RULES OF PROCEDURE General § 401.9 Suspension or amendment of rules. The commission may suspend, repeal, or amend all or any...

  4. The Ottawa Knee Rule: Examining Use in an Academic Emergency Department

    PubMed Central

    Beutel, Bryan G.; Trehan, Samir K.; Shalvoy, Robert M.; Mello, Michael J.

    2012-01-01

    Introduction: The Ottawa Knee Rule is a validated clinical decision rule for determining whether knee radiographs should be obtained in the setting of acute knee trauma. The objectives of this study were to assess physician knowledge of, barriers to implementation of, and compliance with the Ottawa Knee Rule in academic emergency departments (EDs), and evaluate whether patient characteristics predict guideline noncompliance. Methods: A 10 question online survey was distributed to all attending ED physicians working at three affiliated academic EDs to assess knowledge, attitudes and self-reported practice behaviors related to the Ottawa Knee Rule. We also performed a retrospective ED record review of patients 13 years of age and older who presented with acute knee trauma to the 3 study EDs during the 2009 calendar year, and we analyzed ED records for 19 variables. Results: ED physicians (n = 47) correctly answered 73.2% of questions assessing knowledge of the Ottawa Knee Rule. The most commonly cited barriers to implementation were “patient expectations” and system issues, such as “orthopedics referral requirement.” We retrospectively reviewed 838 records, with 260 eligible for study inclusion. The rate of Ottawa Knee Rule compliance was retrospectively determined to be 63.1%. We observed a statistically significant correlation between Ottawa Knee Rule compliance and patient age, but not gender, insurance status, or provider type, among others. Conclusion: Compliance with the Ottawa Knee Rule among academic ED healthcare providers is poor, which was predicted by patient age and not other physician or patient variables. Improving compliance will require comprehensive educational and systemic interventions. PMID:23251717

  5. 49 CFR 393.130 - What are the rules for securing heavy vehicles, equipment and machinery?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false What are the rules for securing heavy vehicles... heavy vehicles, equipment and machinery? (a) Applicability. The rules in this section apply to the transportation of heavy vehicles, equipment and machinery which operate on wheels or tracks, such as front end...

  6. End-to-End Commitment

    NASA Technical Reports Server (NTRS)

    Newcomb, John

    2004-01-01

    The end-to-end test would verify the complex sequence of events from lander separation to landing. Due to the large distances involved and the significant delay time in sending a command and receiving verification, the lander needed to operate autonomously after it separated from the orbiter. It had to sense conditions, make decisions, and act accordingly. We were flying into a relatively unknown set of conditions-a Martian atmosphere of unknown pressure, density, and consistency to land on a surface of unknown altitude, and one which had an unknown bearing strength.

  7. 17 CFR 270.6d-1 - Exemption for certain closed-end investment companies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-end investment companies. 270.6d-1 Section 270.6d-1 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.6d-1 Exemption for certain closed-end investment companies. (a) An application under section 6(d) of the Act shall...

  8. Challenges for Rule Systems on the Web

    NASA Astrophysics Data System (ADS)

    Hu, Yuh-Jong; Yeh, Ching-Long; Laun, Wolfgang

    The RuleML Challenge started in 2007 with the objective of inspiring the issues of implementation for management, integration, interoperation and interchange of rules in an open distributed environment, such as the Web. Rules are usually classified as three types: deductive rules, normative rules, and reactive rules. The reactive rules are further classified as ECA rules and production rules. The study of combination rule and ontology is traced back to an earlier active rule system for relational and object-oriented (OO) databases. Recently, this issue has become one of the most important research problems in the Semantic Web. Once we consider a computer executable policy as a declarative set of rules and ontologies that guides the behavior of entities within a system, we have a flexible way to implement real world policies without rewriting the computer code, as we did before. Fortunately, we have de facto rule markup languages, such as RuleML or RIF to achieve the portability and interchange of rules for different rule systems. Otherwise, executing real-life rule-based applications on the Web is almost impossible. Several commercial or open source rule engines are available for the rule-based applications. However, we still need a standard rule language and benchmark for not only to compare the rule systems but also to measure the progress in the field. Finally, a number of real-life rule-based use cases will be investigated to demonstrate the applicability of current rule systems on the Web.

  9. Medicare program; changes to the Medicare claims appeal procedures; continuation of effectiveness and extension of timeline for publication of final rule. Interim final rule with comment period; continuation of effectiveness and extension of timeline for publication of final rule.

    PubMed

    2009-02-27

    This notice announces the continuation of effectiveness of a Medicare interim final rule with comment period and the extension of the timeline for publication of the final rule. This notice is issued in accordance with section 1871(a)(3)(C) of the Social Security Act (the Act), which allows an interim final rule to remain in effect after the expiration of the timeline specified in section 1871(a)(3)(B) of the Act (the "regular timeline") or, if applicable, at the end of each succeeding 1-year extension to the regular timeline, if prior to the expiration of the timeline, the Secretary publishes in the Federal Register a notice of continuation and explains why the regular timeline or any subsequent extension was not complied with.

  10. 75 FR 34571 - Group Health Plans and Health Insurance Coverage Rules Relating to Status as a Grandfathered...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... Group Health Plans and Health Insurance Coverage Rules Relating to Status as a Grandfathered Health Plan... of Consumer Information and Insurance Oversight of the U.S. Department of Health and Human Services... health insurance coverage offered in connection with a group health plan under the Employee Retirement...

  11. 78 FR 49308 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change Relating To Which Complex...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-69829A; File No. SR-PHLX-2013-65] Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change Relating To Which Complex Orders Can... Complex Orders Can Initiate a Complex Order Live Auction. The document was dated incorrectly. FOR FURTHER...

  12. 75 FR 80553 - Self-Regulatory Organizations; NYSE Amex LLC; Order Approving a Proposed Rule Change Relating to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-63558; File No. SR-NYSEAmex-2010-100] Self-Regulatory Organizations; NYSE Amex LLC; Order Approving a Proposed Rule Change Relating to Complex Orders December 16, 2010. I. Introduction On October 20, 2010, NYSE Amex LLC (``NYSE Amex'' or the ``Exchange...

  13. 76 FR 76205 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... relating to codes of ethics. This Rule requires investment advisers to adopt a code of ethics that reflects... securities laws. Accordingly, procedures designed to prevent the communication and misuse of non-public... securities of large, medium and small capitalization companies across the globe including developed countries...

  14. Racial/ethnic preferences, sex preferences, and perceived discrimination related to end-of-life care.

    PubMed

    Duffy, Sonia A; Jackson, Frances C; Schim, Stephanie M; Ronis, David L; Fowler, Karen E

    2006-01-01

    This study investigated racial/ethnic preferences, sex preferences, and perceived discrimination related to end-of-life care. Ten focus groups and a follow-up survey were conducted to obtain in-depth information on end-of-life preferences across five racial/ethnic groups in Michigan stratified by sex. There were 73 focus group participants, including Arab Muslims, Arab Christians, Hispanics, blacks, and whites. The mean age+/-standard deviation was 67+/-8.5 (range 50-83). A focus group screener was used to recruit participants. A moderator discussion guide was used to guide the focus groups. A take-home questionnaire asked about demographic information and end-of-life issues. Arab Americans were in favor of making peace on earth and were against assisted suicide, extending life artificially, nursing homes, and telling the patient "bad news." Hispanic and black women were against assisted suicide and in favor of extending life, whereas the men in these groups felt the opposite. Hispanic women spoke of not wanting a feeding tube and would consider alternative medicine. Blacks were least opposed to nursing homes. For whites, it was important to have choices. When asked about discrimination related to end-of-life care, Muslim women spoke of cultural barriers, blacks spoke of inequities in the past, and whites spoke of age discrimination and abandonment when dying. As the population becomes more diverse and continues to age, it will be important to provide culturally and sex-sensitive end-of-life interventions to increase patient/family satisfaction and allocate resources appropriately.

  15. Tests of ecogeographical relationships in a non-native species: what rules avian morphology?

    PubMed

    Cardilini, Adam P A; Buchanan, Katherine L; Sherman, Craig D H; Cassey, Phillip; Symonds, Matthew R E

    2016-07-01

    The capacity of non-native species to undergo rapid adaptive change provides opportunities to research contemporary evolution through natural experiments. This capacity is particularly true when considering ecogeographical rules, to which non-native species have been shown to conform within relatively short periods of time. Ecogeographical rules explain predictable spatial patterns of morphology, physiology, life history and behaviour. We tested whether Australian populations of non-native starling, Sturnus vulgaris, introduced to the country approximately 150 years ago, exhibited predicted environmental clines in body size, appendage size and heart size (Bergmann's, Allen's and Hesse's rules, respectively). Adult starlings (n = 411) were collected from 28 localities from across eastern Australia from 2011 to 2012. Linear models were constructed to examine the relationships between morphology and local environment. Patterns of variation in body mass and bill surface area were consistent with Bergmann's and Allen's rules, respectively (small body size and larger bill size in warmer climates), with maximum summer temperature being a strongly weighted predictor of both variables. In the only intraspecific test of Hesse's rule in birds to date, we found no evidence to support the idea that relative heart size will be larger in individuals which live in colder climates. Our study does provide evidence that maximum temperature is a strong driver of morphological adaptation for starlings in Australia. The changes in morphology presented here demonstrate the potential for avian species to make rapid adaptive changes in relation to a changing climate to ameliorate the effects of heat stress.

  16. 77 FR 56905 - Self-Regulatory Organizations; NYSE MKT LLC; Order Approving Proposed Rule Change Amending Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-67811; File No. SR-NYSEMKT-2012-26] Self... Add Supplementary Material Relating to a Cross Function That Provides a Regulation NMS Rule 611... 611 of Regulation NMS (``Rule 611'').\\5\\ The Exchange contends that, in today's fast-moving electronic...

  17. 76 FR 2931 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-63609; File No. SR-NYSEArca-2010-116] Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating to the Listing and Trading of the WisdomTree Asia Bond Fund December 27, 2010. Correction In notice document 2010...

  18. 76 FR 16462 - Self-Regulatory Organizations; NASDAQ OMX BX LLC; Order Approving a Proposed Rule Change Relating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-64090; File No. SR-BX-2011-007] Self-Regulatory Organizations; NASDAQ OMX BX LLC; Order Approving a Proposed Rule Change Relating to Permanent Approval of the BX and NES Inbound Routing Relationship March 17, 2011. I. Introduction On January 28, 2011, NASDAQ...

  19. A pilot study of the attitudes of Australian Rules footballers towards protective headgear.

    PubMed

    Finch, C F; McIntosh, A S; McCrory, P; Zazryn, T

    2003-12-01

    Despite a relatively high risk of injury to participants of Australian Rules football, very few players report wearing protective equipment. The aim of this paper is to describe the results of a pilot survey of the attitudes of community-level Australian Rules football players towards protective headgear and the risk of head injury. Seventy players from four purposefully chosen clubs in metropolitan Melbourne completed a self-report questionnaire at the end of the 2000-playing season. Almost all players (91.4%) reported they did not wear protective headgear during the 2000 season. Non-headgear users said that headgear was too uncomfortable (47.4%) and they didn't like it (42.1%). However, 80.0% of non-users said they would wear it if it prevented injury. The major motivation for wearing headgear was to prevent injury. Players considered rugby, boxing and driving a car, to be associated with a higher-risk of head injury than Australian Rules football. As a group, the players perceived the risk of head injury in Australian Rules football to be low to moderate when compared to other sports and activities. This partially explains why so few players wore protective headgear. Repeat surveys on a larger sample should be conducted to further understand the attitudes towards protective headgear and perceptions of risk in community-level Australian football players.

  20. 39 CFR 963.2 - Scope of the rules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Scope of the rules. 963.2 Section 963.2 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO VIOLATIONS OF THE PANDERING ADVERTISEMENTS STATUTE, 39 U.S.C. 3008 § 963.2 Scope of the rules. These rules of practice are applicable to cases in which the...

  1. The age 60 rule.

    PubMed

    2004-08-01

    The impetus for amending the Age 60 Rule compels the review of recent scientific literature pertinent to pilot age and performance. The Rule has been the subject of extensive debate among policymakers and the aviation community. The aviation medical community is in a position to continue research and discussion that may provide additional evidence for the development of future policy decisions. Those addressing the future of the Age 60 Rule may benefit from understanding the nature and limitations of these studies, whether their outcomes are conclusive or not. Hopefully, some measure of guidance may be achieved as they address pilot age limits and related safety, economic, and operational issues of the aviation industry.

  2. Relating the microscopic rules in coalescence-fragmentation models to the cluster-size distribution

    NASA Astrophysics Data System (ADS)

    Ruszczycki, B.; Burnett, B.; Zhao, Z.; Johnson, N. F.

    2009-11-01

    Coalescence-fragmentation problems are now of great interest across the physical, biological, and social sciences. They are typically studied from the perspective of rate equations, at the heart of which are the rules used for coalescence and fragmentation. Here we discuss how changes in these microscopic rules affect the macroscopic cluster-size distribution which emerges from the solution to the rate equation. Our analysis elucidates the crucial role that the fragmentation rule can play in such dynamical grouping models. We focus our discussion on two well-known models whose fragmentation rules lie at opposite extremes. In particular, we provide a range of generalizations and new analytic results for the well-known model of social group formation developed by Eguíluz and Zimmermann, [Phys. Rev. Lett. 85, 5659 (2000)]. We develop analytic perturbation treatments of this original model, and extend the analytic analysis to the treatment of growing and declining populations.

  3. 75 FR 33376 - Determination Related to Serbia Under Section 7072(c) of the Department of State, Foreign...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... to end Serbian financial, political, security and other support which has served to maintain separate... minority rights and the rule of law. This Determination and related Memorandum of Justification shall be...

  4. On the fusion of tuning parameters of fuzzy rules and neural network

    NASA Astrophysics Data System (ADS)

    Mamuda, Mamman; Sathasivam, Saratha

    2017-08-01

    Learning fuzzy rule-based system with neural network can lead to a precise valuable empathy of several problems. Fuzzy logic offers a simple way to reach at a definite conclusion based upon its vague, ambiguous, imprecise, noisy or missing input information. Conventional learning algorithm for tuning parameters of fuzzy rules using training input-output data usually end in a weak firing state, this certainly powers the fuzzy rule and makes it insecure for a multiple-input fuzzy system. In this paper, we introduce a new learning algorithm for tuning the parameters of the fuzzy rules alongside with radial basis function neural network (RBFNN) in training input-output data based on the gradient descent method. By the new learning algorithm, the problem of weak firing using the conventional method was addressed. We illustrated the efficiency of our new learning algorithm by means of numerical examples. MATLAB R2014(a) software was used in simulating our result The result shows that the new learning method has the best advantage of training the fuzzy rules without tempering with the fuzzy rule table which allowed a membership function of the rule to be used more than one time in the fuzzy rule base.

  5. 47 CFR 90.5 - Other applicable rule parts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MOBILE RADIO SERVICES General Information § 90.5 Other applicable rule parts. Other Commission rule parts..., and treaties. This part also contains standards and procedures concerning marketing of radio frequency... contains rules relating to commercial mobile radio services. (i) Part 20 which governs commercial mobile...

  6. 49 CFR 389.25 - Additional rule making proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Additional rule making proceedings. 389.25 Section 389.25 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... PROCEDURES-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.25 Additional rule...

  7. 49 CFR 389.25 - Additional rule making proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Additional rule making proceedings. 389.25 Section 389.25 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER... PROCEDURES-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.25 Additional rule...

  8. 19 CFR 177.2 - Submission of ruling requests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... indicated, if known. Requests for tariff classification rulings should be addressed to the Director.... Customs and Border Protection, New York, New York, 10119, Attn: Classification Ruling Requests, New York... relevant customs and related laws. (ii) Tariff classification rulings. (A) If the transaction involves the...

  9. 19 CFR 177.2 - Submission of ruling requests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... indicated, if known. Requests for tariff classification rulings should be addressed to the Director.... Customs and Border Protection, New York, New York, 10119, Attn: Classification Ruling Requests, New York... relevant customs and related laws. (ii) Tariff classification rulings. (A) If the transaction involves the...

  10. Usage of the Jess Engine, Rules and Ontology to Query a Relational Database

    NASA Astrophysics Data System (ADS)

    Bak, Jaroslaw; Jedrzejek, Czeslaw; Falkowski, Maciej

    We present a prototypical implementation of a library tool, the Semantic Data Library (SDL), which integrates the Jess (Java Expert System Shell) engine, rules and ontology to query a relational database. The tool extends functionalities of previous OWL2Jess with SWRL implementations and takes full advantage of the Jess engine, by separating forward and backward reasoning. The optimization of integration of all these technologies is an advancement over previous tools. We discuss the complexity of the query algorithm. As a demonstration of capability of the SDL library, we execute queries using crime ontology which is being developed in the Polish PPBW project.

  11. n-3 Fatty Acids, Ventricular Arrhythmia–Related Events, and Fatal Myocardial Infarction in Postmyocardial Infarction Patients With Diabetes

    PubMed Central

    Kromhout, Daan; Geleijnse, Johanna M.; de Goede, Janette; Oude Griep, Linda M.; Mulder, Barbara J.M.; de Boer, Menko-Jan; Deckers, Jaap W.; Boersma, Eric; Zock, Peter L.; Giltay, Erik J.

    2011-01-01

    OBJECTIVE We carried out a secondary analysis in high-risk patients with a previous myocardial infarction (MI) and diabetes in the Alpha Omega Trial. We tested the hypothesis that in these patients an increased intake of the n-3 fatty acids eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linolenic acid (ALA) will reduce the incidence of ventricular arrhythmias and fatal MI. RESEARCH DESIGN AND METHODS A subgroup of 1,014 post-MI patients with diabetes aged 60–80 years was randomly allocated to receive one of four trial margarines, three with an additional amount of n-3 fatty acids and one placebo for 40 months. The end points were ventricular arrhythmia–related events and fatal MI. The data were analyzed according to the intention-to-treat principle, using multivariable Cox proportional hazards models. RESULTS The patients consumed on average 18.6 g of margarine per day, which resulted in an additional intake of 223 mg EPA plus 149 mg DHA and/or 1.9 g ALA in the active treatment groups. During follow-up, 29 patients developed a ventricular arrhythmia–related events and 27 had a fatal MI. Compared with placebo patients, the EPA-DHA plus ALA group experienced less ventricular arrhythmia–related events (hazard ratio 0.16; 95% CI 0.04–0.69). These n-3 fatty acids also reduced the combined end-point ventricular arrhythmia–related events and fatal MI (0.28; 0.11–0.71). CONCLUSIONS Our results suggest that low-dose supplementation of n-3 fatty acids exerts a protective effect against ventricular arrhythmia–related events in post-MI patients with diabetes. PMID:22110169

  12. 26 CFR 1.614-3 - Rules relating to separate operating mineral interests in the case of mines.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Rules relating to separate operating mineral interests in the case of mines. 1.614-3 Section 1.614-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1...

  13. Relative importance of N-nitrosodimethylamine compared to total N-nitrosamines in drinking waters.

    PubMed

    Dai, Ning; Mitch, William A

    2013-04-16

    A U.S.-wide occurrence survey conducted as part of the Unregulated Contaminant Monitoring Rule 2 found that N-nitrosodimethylamine (NDMA) was present in 34% of chloraminated drinking water samples but was the most prevalent of the six N-nitrosamines evaluated using U.S. Environmental Protection Agency (EPA) Method 521. If the U.S. EPA considers limiting exposures to N-nitrosamines as a group, a critical question is whether NDMA is the most prevalent N-nitrosamine or whether significant concentrations occur for N-nitrosamines other than those captured by EPA Method 521. A total N-nitrosamine assay was developed and applied to 36 drinking water plant effluents or distribution system samples from 11 utilities, including 9 utilities that practiced chloramination for secondary disinfection. Concurrent application of EPA Method 521 indicated that NDMA was the most prevalent of the Method 521 N-nitrosamines yet accounted for ∼5% of the total N-nitrosamine pool on a median basis. Among eight plant influent waters, NDMA was detected once, while total N-nitrosamines were detected in five samples, suggesting the importance of source water protection. Similar to NDMA, total N-nitrosamine concentrations in source waters increased after chloramination. Chloramines were applied to organic precursors serving as models for pristine natural organic matter, algal exudate, wastewater effluent, and polyDADMAC quaternary amine-based coagulation polymers. While high yields of NDMA were restricted to the wastewater effluent and polyDADMAC, high yields of total N-nitrosamines were observed from the algal exudate, the wastewater effluent, and polyDADMAC. The results suggest that N-nitrosamines as a class may be more prevalent than suggested by occurrence surveys conducted using EPA Method 521.

  14. Correlating Temporal Rules to Time-Series Data With Rule-Based Intuition

    DTIC Science & Technology

    2010-03-01

    t i m e o b j e c t and r e t u r n s True ( i n r u l e ) or F a l s e ( n o t i n r u l e ) . Des ign : r u l e l i s t − an a r r a y t h...e . d a t e o b j e c t s . ””” def i n i t ( s e l f , name , days , i g n o r e y e a r =True ) : s e l f . name = name s e l f . days = days 49 s...a l . tm wday == 6 r u l e l i s t . append ( Sunday ( ) ) c l a s s J a n u a r y ( TimeRule ) : ””” I s True i f i t i s January

  15. A Novel Method for Relative Quantitation of N-Glycans by Isotopic Labeling Using 18O-Water

    PubMed Central

    Tao, Shujuan; Orlando, Ron

    2014-01-01

    Quantitation is an essential aspect of comprehensive glycomics study. Here, a novel isotopic-labeling method is described for N-glycan quantitation using 18O-water. The incorporation of the 18O-labeling into the reducing end of N-glycans is simply and efficiently achieved during peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase F release. This process provides a 2-Da mass difference compared with the N-glycans released in 16O-water. A mathematical calculation method was also developed to determine the 18O/16O ratios from isotopic peaks. Application of this method to several standard glycoprotein mixtures and human serum demonstrated that this method can facilitate the relative quantitation of N-glycans over a linear dynamic range of two orders, with high accuracy and reproducibility. PMID:25365792

  16. 76 FR 34123 - Determination Related to Serbia Under Section 7072(c) of the Department of State, Foreign...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... consistent with the Dayton Accords to end Serbian financial, political, security and other support which has... which reflect a respect for minority rights and the rule of law. This Determination and related...

  17. 41 CFR 60-250.83 - Rulings and interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Rulings and interpretations. 60-250.83 Section 60-250.83 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS Ancillary Matters § 60-250.83 Rulings and interpretations. Rulings under or...

  18. 41 CFR 60-250.83 - Rulings and interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Rulings and interpretations. 60-250.83 Section 60-250.83 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS Ancillary Matters § 60-250.83 Rulings and interpretations. Rulings under or...

  19. 41 CFR 60-250.83 - Rulings and interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Rulings and interpretations. 60-250.83 Section 60-250.83 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS Ancillary Matters § 60-250.83 Rulings and interpretations. Rulings under or...

  20. 41 CFR 60-250.83 - Rulings and interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Rulings and interpretations. 60-250.83 Section 60-250.83 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS Ancillary Matters § 60-250.83 Rulings and interpretations. Rulings under or...

  1. 49 CFR 389.29 - Adoption of final rules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Adoption of final rules. 389.29 Section 389.29 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY...-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.29 Adoption of final rules...

  2. 49 CFR 389.29 - Adoption of final rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Adoption of final rules. 389.29 Section 389.29 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY...-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.29 Adoption of final rules...

  3. 49 CFR 389.31 - Petitions for rule making.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Petitions for rule making. 389.31 Section 389.31 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY...-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.31 Petitions for rule...

  4. 49 CFR 389.13 - Initiation of rule making.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Initiation of rule making. 389.13 Section 389.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY...-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.13 Initiation of rule...

  5. 49 CFR 389.13 - Initiation of rule making.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Initiation of rule making. 389.13 Section 389.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY...-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.13 Initiation of rule...

  6. 49 CFR 389.31 - Petitions for rule making.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Petitions for rule making. 389.31 Section 389.31 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY...-FEDERAL MOTOR CARRIER SAFETY REGULATIONS Procedures for Adoption of Rules § 389.31 Petitions for rule...

  7. [Incidence and causes of early end in awake surgery for language mapping not directly related to eloquence].

    PubMed

    Villalba, Gloria; Pacreu, Susana; Fernández-Candil, Juan Luis; León, Alba; Serrano, Laura; Conesa, Gerardo

    2016-01-01

    The incidence and causes that may lead to an early end (unfinished cortical/subcortical mapping) of awake surgery for language mapping are little known. A study was conducted on 41 patients with brain glioma located in the language area that had awake surgery under conscious sedation. Surgery was ended early in 6 patients. The causes were: tonic-clonic seizure (1), lack of cooperation due to fatigue/sleep (4), whether or not word articulation was involved, a decreased level of consciousness for ammonia encephalopathy that required endotracheal intubation (1). There are causes that could be expected and in some cases avoided. Tumour size, preoperative aphasia, valproate treatment, and type of anaesthesia used are variables to consider to avoid failure in awake surgery for language mapping. With these results, the following measures are proposed: l) If the tumour is large, perform surgery in two times to avoid fatigue, 2) if patient has a preoperative aphasia, do not use sedation during surgery to ensure that sleepiness does not cause worse word articulation, 3) if the patient is on valproate treatment, it is necessary to rule out the pre-operative symptoms that are not due to ammonia encephalopathy. Copyright © 2015 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  8. Stressed out and overcommitted! The relationships between time demands and family rules and parents’ and their child’s weight status

    PubMed Central

    Hearst, Mary O.; Sevcik, Sarah; Fulkerson, Jayne A.; Pasch, Keryn E.; Harnack, Lisa J.; Lytle, Leslie A.

    2013-01-01

    Objective To determine the relationship between parent time demands and presence and enforcement of family rules and parent/child dyad weight status. Methods Dyads of one child/parent per family (n=681dyads), Twin Cities, Minnesota, 2007–2008 had measured height/weight and a survey of demographics, time demands and family rules-related questions. Parent/child dyads were classified into four healthy weight/overweight categories. Multivariate linear associations were analyzed with SAS, testing for interaction by work status and family composition (p<0.10). Results In adjusted models, lack of family rules and difficulty with rule enforcement were statistically lower in dyads in which the parent/child was healthy weight compared to dyads in which the parent/child was both overweight (Difference in family rules scores=0.49, p=0.03; difference in rule enforcement scores=1.09, p=<0.01). Of parents who worked full-time, healthy weight dyads reported lower time demands than other dyads (Difference in time demands scores=1.44, p=0.01). Conclusions Family experiences of time demands and use of family rules are related to the weight status of parents and children within families. PMID:22228775

  9. 76 FR 13937 - Rules of Practice in Proceedings Relative to False Representation and Lottery Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ... appropriate affidavit of service. The new rule clarifies that discovery does not need to be filed with the... participate in voluntary discovery without the intervention of the presiding officer and to clarify the discovery rules. Accordingly, the Postal Service invites public comment on the following proposed rules...

  10. Continental extension, magmatism and elevation; formal relations and rules of thumb

    USGS Publications Warehouse

    Lachenbruch, A.H.; Morgan, P.

    1990-01-01

    To investigate simplified relations between elevation and the extensional, magmatic and thermal processes that influence lithosphere buoyancy, we assume that the lithosphere floats on an asthenosphere of uniform density and has no flexural strength. A simple graph relating elevation to lithosphere density and thickness provides an overview of expectable conditions around the earth and a simple test for consistancy of continental and oceanic lithosphere models. The mass-balance relations yield simple general rules for estimating elevation changes caused by various tectonic, magmatic and thermal processes without referring to detailed models. The rules are general because they depend principally on buoyancy, which under our assumptions is specified by elevation, a known quantity; they do not generally require a knowledge of lithosphere thickness and density. The elevation of an extended terrain contains important information on its tectonic and magmatic history. In the Great Basin where Cenozoic extension is estimated to be 100%, the present high mean elevation ( ~ 1.75 km) probably requires substantial low-density magmatic contributions to the extending lithosphere. The elevation cannot be reasonably explained solely as the buoyant residue of a very high initial terrane, or of a lithosphere that was initially very thick and subsequently delaminated and heated. Even models with a high initial elevation typically call for 10 km or so of accumulated magmatic material of near-crustal density. To understand the evolution of the Great Basin, it is important to determine whether such intruded material is present; some could replenish the stretching crust by underplating and crustal intrusion and some might reside in the upper mantle. The elevation maintained or approached by an intruded extending lithosphere depends on the ratio B of how fast magma is supplied from the asthenosphere ( b km/Ma) to how fast the lithosphere spreads the magma out by extension (?? Ma-1). For a

  11. 26 CFR 1.412(c)(3)-2 - Effective dates and transitional rules relating to reasonable funding methods.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... to reasonable funding methods. 1.412(c)(3)-2 Section 1.412(c)(3)-2 Internal Revenue INTERNAL REVENUE... to reasonable funding methods. (a) Introduction. This section prescribes effective dates for rules relating to reasonable funding methods, under section 412(c)(3) and § 1.412(c)(3)-1. Also, this section...

  12. 26 CFR 1.412(c)(3)-2 - Effective dates and transitional rules relating to reasonable funding methods.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to reasonable funding methods. 1.412(c)(3)-2 Section 1.412(c)(3)-2 Internal Revenue INTERNAL REVENUE... to reasonable funding methods. (a) Introduction. This section prescribes effective dates for rules relating to reasonable funding methods, under section 412(c)(3) and § 1.412(c)(3)-1. Also, this section...

  13. 26 CFR 1.412(c)(3)-2 - Effective dates and transitional rules relating to reasonable funding methods.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... to reasonable funding methods. 1.412(c)(3)-2 Section 1.412(c)(3)-2 Internal Revenue INTERNAL REVENUE... to reasonable funding methods. (a) Introduction. This section prescribes effective dates for rules relating to reasonable funding methods, under section 412(c)(3) and § 1.412(c)(3)-1. Also, this section...

  14. 26 CFR 1.412(c)(3)-2 - Effective dates and transitional rules relating to reasonable funding methods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... to reasonable funding methods. 1.412(c)(3)-2 Section 1.412(c)(3)-2 Internal Revenue INTERNAL REVENUE... to reasonable funding methods. (a) Introduction. This section prescribes effective dates for rules relating to reasonable funding methods, under section 412(c)(3) and § 1.412(c)(3)-1. Also, this section...

  15. Patient Protection and Affordable Care Act; health insurance market rules. Final rule.

    PubMed

    2013-02-27

    This final rule implements provisions related to fair health insurance premiums, guaranteed availability, guaranteed renewability, single risk pools, and catastrophic plans, consistent with title I of the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act of 2010, referred to collectively as the Affordable Care Act. The final rule clarifies the approach used to enforce the applicable requirements of the Affordable Care Act with respect to health insurance issuers and group health plans that are non-federal governmental plans. This final rule also amends the standards for health insurance issuers and states regarding reporting, utilization, and collection of data under the federal rate review program, and revises the timeline for states to propose state-specific thresholds for review and approval by the Centers for Medicare & Medicaid Services (CMS).

  16. The Impact of Family Rules on Children's Eating Habits, Sedentary Behaviors, and Weight Status.

    PubMed

    Lederer, Alyssa M; King, Mindy H; Sovinski, Danielle; Kim, Nayoung

    2015-08-01

    Family rules may be influential in helping children to modify their dietary and sedentary behaviors, which are important modifiable risk factors for childhood obesity. However, data examining family rules in relation to children's health behaviors and weight status are limited. This cross-sectional study examined differences in family rules by demographic characteristics of students enrolled in the HEROES (Healthy, Energetic, Ready, Outstanding, Enthusiastic Schools) Initiative, a school-based childhood obesity prevention program. It also investigated the relationship between eating and screen time family rules and six eating and screen time behaviors: fast food consumption; soft drink consumption; fruit and vegetable intake; television viewing; computer use; and video game use, in addition to the association between family rules and children's weight status. Measures included self-reported behavioral data and anthropometric data from students in fourth to eighth grade at 16 schools (N=2819) in a tri-state area of the United States in spring 2012. Approximately one-third of students had each of the family rules examined. Whereas the profile of students who had specific rules varied, in general, younger, female, white, and low socioeconomic status students were more likely to have rules than their counterparts. Family rules were associated with healthier outcomes for each of the six behaviors examined (p<0.001), even after controlling for demographics (p<0.001). However, family rules were not associated with children's weight status. This study demonstrates that family rules are an underutilized strategy to promote healthier eating habits and reduce children's screen time hours and may serve as an intermediary mechanism to curb childhood obesity.

  17. Pancreatitis with normal lipase and amylase in setting of end-stage renal disease.

    PubMed

    Sharma, Anuj; Masood, Umair; Khan, Babar; Chawla, Kunal; Manocha, Divey

    2017-09-01

    Pancreatitis with normal lipase and amylase level is a rare phenomenon. This is especially true in patient with end-stage renal disease as lipase and amylase are renally excreted. Literature review reveals previous case report of pancreatitis with normal lipase and amylase level, however, none of them occurred in the setting of end-stage renal disease. Our case is the first such reported case of pancreatitis in such setting. Here we report a 30year old male with past medical history of end-stage renal disease who presented in emergency department with acute abdominal pain. Laboratory work up revealed normal lipase and amylase level. However, radiological work up was consistent with pancreatitis. This case report highlight the importance of taking the overall clinical picture rather than laboratory work up to rule in or rule out the diagnosis of pancreatitis. Furthermore, this should also serve an important reminder for clinicians to further investigate where clinical suspicion for pancreatitis is high. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Related Rules and Programs that Help States Attain PM Standards

    EPA Pesticide Factsheets

    EPA’s national and regional rules to reduce emissions of pollutants that form particle pollution will help state and local governments meet the PM NAAQS. A number of voluntary programs also are helping areas reduce fine PM pollution.

  19. 16 CFR 313.18 - Effective date; transition rule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Effective date; transition rule. 313.18... PRIVACY OF CONSUMER FINANCIAL INFORMATION Relation to Other Laws; Effective Date § 313.18 Effective date; transition rule. (a) Effective date—(1) General rule. This part is effective November 13, 2000. In order to...

  20. Rule-Based Event Processing and Reaction Rules

    NASA Astrophysics Data System (ADS)

    Paschke, Adrian; Kozlenkov, Alexander

    Reaction rules and event processing technologies play a key role in making business and IT / Internet infrastructures more agile and active. While event processing is concerned with detecting events from large event clouds or streams in almost real-time, reaction rules are concerned with the invocation of actions in response to events and actionable situations. They state the conditions under which actions must be taken. In the last decades various reaction rule and event processing approaches have been developed, which for the most part have been advanced separately. In this paper we survey reaction rule approaches and rule-based event processing systems and languages.

  1. Sum Rules, Classical and Quantum - A Pedagogical Approach

    NASA Astrophysics Data System (ADS)

    Karstens, William; Smith, David Y.

    2014-03-01

    Sum rules in the form of integrals over the response of a system to an external probe provide general analytical tools for both experiment and theory. For example, the celebrated f-sum rule gives a system's plasma frequency as an integral over the optical-dipole absorption spectrum regardless of the specific spectral distribution. Moreover, this rule underlies Smakula's equation for the number density of absorbers in a sample in terms of the area under their absorption bands. Commonly such rules are derived from quantum-mechanical commutation relations, but many are fundamentally classical (independent of ℏ) and so can be derived from more transparent mechanical models. We have exploited this to illustrate the fundamental role of inertia in the case of optical sum rules. Similar considerations apply to sum rules in many other branches of physics. Thus, the ``attenuation integral theorems'' of ac circuit theory reflect the ``inertial'' effect of Lenz's Law in inductors or the potential energy ``storage'' in capacitors. These considerations are closely related to the fact that the real and imaginary parts of a response function cannot be specified independently, a result that is encapsulated in the Kramers-Kronig relations. Supported in part by the US Department of Energy, Office of Nuclear Physics under contract DE-AC02-06CH11357.

  2. 77 FR 11606 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Order Approving Proposed Rule Change Relating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... stock execution clerk from the Exchange's rules. Exchange Rule 1090 currently defines a stock execution... Rule 1090, Commentary .01(a). The Exchange has represented that this registration capacity is outdated...

  3. Toward rules relating zinc finger protein sequences and DNA binding site preferences.

    PubMed

    Desjarlais, J R; Berg, J M

    1992-08-15

    Zinc finger proteins of the Cys2-His2 type consist of tandem arrays of domains, where each domain appears to contact three adjacent base pairs of DNA through three key residues. We have designed and prepared a series of variants of the central zinc finger within the DNA binding domain of Sp1 by using information from an analysis of a large data base of zinc finger protein sequences. Through systematic variations at two of the three contact positions (underlined), relatively specific recognition of sequences of the form 5'-GGGGN(G or T)GGG-3' has been achieved. These results provide the basis for rules that may develop into a code that will allow the design of zinc finger proteins with preselected DNA site specificity.

  4. 39 CFR 963.1 - Authority for the rules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Authority for the rules. 963.1 Section 963.1 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO VIOLATIONS OF THE PANDERING ADVERTISEMENTS STATUTE, 39 U.S.C. 3008 § 963.1 Authority for the rules. These...

  5. 77 FR 52977 - Regulatory Capital Rules: Advanced Approaches Risk-Based Capital Rule; Market Risk Capital Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... Corporation 12 CFR Parts 324, 325 Regulatory Capital Rules: Advanced Approaches Risk-Based Capital Rule... 325 RIN 3064-AD97 Regulatory Capital Rules: Advanced Approaches Risk-Based Capital Rule; Market Risk... the agencies' current capital rules. In this NPR (Advanced Approaches and Market Risk NPR) the...

  6. Analysis on composition rules of Chinese patent drugs treating pain-related diseases based on data mining method.

    PubMed

    Tang, Shi-Huan; Shen, Dan; Yang, Hong-Jun

    2017-08-24

    To analyze the composition rules of oral prescriptions in the treatment of headache, stomachache and dysmenorrhea recorded in National Standard for Chinese Patent Drugs (NSCPD) enacted by Ministry of Public Health of China and then make comparison between them to better understand pain treatment in different regions of human body. Constructed NSCPD database had been constructed in 2014. Prescriptions treating the three pain-related diseases were searched and screened from the database. Then data mining method such as association rules analysis and complex system entropy method integrated in the data mining software Traditional Chinese Medicine Inheritance Support System (TCMISS) were applied to process the data. Top 25 drugs with high frequency in the treatment of each disease were selected, and 51, 33 and 22 core combinations treating headache, stomachache and dysmenorrhea respectively were mined out as well. The composition rules of the oral prescriptions for treating headache, stomachache and dysmenorrhea recorded in NSCPD has been summarized. Although there were similarities between them, formula varied according to different locations of pain. It can serve as an evidence and reference for clinical treatment and new drug development.

  7. The effect of multiple primary rules on population-based cancer survival

    PubMed Central

    Weir, Hannah K.; Johnson, Christopher J.; Thompson, Trevor D.

    2015-01-01

    Purpose Different rules for registering multiple primary (MP) cancers are used by cancer registries throughout the world, making international data comparisons difficult. This study evaluates the effect of Surveillance, Epidemiology, and End Results (SEER) and International Association of Cancer Registries (IACR) MP rules on population-based cancer survival estimates. Methods Data from five US states and six metropolitan area cancer registries participating in the SEER Program were used to estimate age-standardized relative survival (RS%) for first cancers-only and all first cancers matching the selection criteria according to SEER and IACR MP rules for all cancer sites combined and for the top 25 cancer site groups among men and women. Results During 1995–2008, the percentage of MP cancers (all sites, both sexes) increased 25.4 % by using SEER rules (from 14.6 to 18.4 %) and 20.1 % by using IACR rules (from 13.2 to 15.8 %). More MP cancers were registered among females than among males, and SEER rules registered more MP cancers than IACR rules (15.8 vs. 14.4 % among males; 17.2 vs. 14.5 % among females). The top 3 cancer sites with the largest differences were melanoma (5.8 %), urinary bladder (3.5 %), and kidney and renal pelvis (2.9 %) among males, and breast (5.9 %), melanoma (3.9 %), and urinary bladder (3.4 %) among females. Five-year survival estimates (all sites combined) restricted to first primary cancers-only were higher than estimates by using first site-specific primaries (SEER or IACR rules), and for 11 of 21 sites among males and 11 of 23 sites among females. SEER estimates are comparable to IACR estimates for all site-specific cancers and marginally higher for all sites combined among females (RS 62.28 vs. 61.96 %). Conclusion Survival after diagnosis has improved for many leading cancers. However, cancer patients remain at risk of subsequent cancers. Survival estimates based on first cancers-only exclude a large and increasing number of MP

  8. Pushing the rules: effects and aftereffects of deliberate rule violations.

    PubMed

    Wirth, Robert; Pfister, Roland; Foerster, Anna; Huestegge, Lynn; Kunde, Wilfried

    2016-09-01

    Most of our daily life is organized around rules and social norms. But what makes rules so special? And what if one were to break a rule intentionally? Can we simply free us from the present set of rules or do we automatically adhere to them? How do rule violations influence subsequent behavior? To investigate the effects and aftereffects of violating simple S-R rule, we conducted three experiments that investigated continuous finger-tracking responses on an iPad. Our experiments show that rule violations are distinct from rule-based actions in both response times and movement trajectories, they take longer to initiate and execute, and their movement trajectory is heavily contorted. Data not only show differences between the two types of response (rule-based vs. violation), but also yielded a characteristic pattern of aftereffects in case of rule violations: rule violations do not trigger adaptation effects that render further rule violations less difficult, but every rule violation poses repeated effort on the agent. The study represents a first step towards understanding the signature and underlying mechanisms of deliberate rule violations, they cannot be acted out by themselves, but require the activation of the original rule first. Consequently, they are best understood as reformulations of existing rules that are not accessible on their own, but need to be constantly derived from the original rule, with an add-on that might entail an active tendency to steer away from mental representations that reflect (socially) unwanted behavior.

  9. Mechanisms of rule acquisition and rule following in inductive reasoning.

    PubMed

    Crescentini, Cristiano; Seyed-Allaei, Shima; De Pisapia, Nicola; Jovicich, Jorge; Amati, Daniele; Shallice, Tim

    2011-05-25

    Despite the recent interest in the neuroanatomy of inductive reasoning processes, the regional specificity within prefrontal cortex (PFC) for the different mechanisms involved in induction tasks remains to be determined. In this study, we used fMRI to investigate the contribution of PFC regions to rule acquisition (rule search and rule discovery) and rule following. Twenty-six healthy young adult participants were presented with a series of images of cards, each consisting of a set of circles numbered in sequence with one colored blue. Participants had to predict the position of the blue circle on the next card. The rules that had to be acquired pertained to the relationship among succeeding stimuli. Responses given by subjects were categorized in a series of phases either tapping rule acquisition (responses given up to and including rule discovery) or rule following (correct responses after rule acquisition). Mid-dorsolateral PFC (mid-DLPFC) was active during rule search and remained active until successful rule acquisition. By contrast, rule following was associated with activation in temporal, motor, and medial/anterior prefrontal cortex. Moreover, frontopolar cortex (FPC) was active throughout the rule acquisition and rule following phases before a rule became familiar. We attributed activation in mid-DLPFC to hypothesis generation and in FPC to integration of multiple separate inferences. The present study provides evidence that brain activation during inductive reasoning involves a complex network of frontal processes and that different subregions respond during rule acquisition and rule following phases.

  10. 41 CFR 60-30.18 - Rules of evidence.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Rules of evidence. 60-30.18 Section 60-30.18 Public Contracts and Property Management Other Provisions Relating to Public... ORDER 11246 Hearings and Related Matters § 60-30.18 Rules of evidence. In any hearing, decision, or...

  11. 41 CFR 60-30.18 - Rules of evidence.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Rules of evidence. 60-30.18 Section 60-30.18 Public Contracts and Property Management Other Provisions Relating to Public... ORDER 11246 Hearings and Related Matters § 60-30.18 Rules of evidence. In any hearing, decision, or...

  12. Medicare program; revision to accrual basis of accounting policy. Health Care Financing Administration (HCFA), HHS. Final rule.

    PubMed

    1999-09-27

    Medicare policy provides that payroll taxes that a provider becomes obligated to remit to governmental agencies are included in allowable costs only in the cost reporting period in which payment (upon which the payroll taxes are based) is actually made to an employee. Therefore, for payroll accrued in 1 year but not paid until the next year, the associated payroll taxes are not an allowable cost until the next year. This final rule provides for an exception when payment would be made to the employee in the current year but for the fact the regularly scheduled payment date is after the end of the year. In that case, the rule requires allowance in the current year of accrued taxes on payroll that is accrued through the end of the year but not paid until the beginning of the next year, thus allowing accrued taxes on end-of-the year payroll in the same year that the accrual of the payroll itself is allowed. The effect of this rule is not on the allowability of cost but rather only on the timing of payment; that is, the cost of payroll taxes on end-of-the-year payroll is allowable in the current period rather than in the following period.

  13. Choice Rules and Accumulator Networks

    PubMed Central

    2015-01-01

    This article presents a preference accumulation model that can be used to implement a number of different multi-attribute heuristic choice rules, including the lexicographic rule, the majority of confirming dimensions (tallying) rule and the equal weights rule. The proposed model differs from existing accumulators in terms of attribute representation: Leakage and competition, typically applied only to preference accumulation, are also assumed to be involved in processing attribute values. This allows the model to perform a range of sophisticated attribute-wise comparisons, including comparisons that compute relative rank. The ability of a preference accumulation model composed of leaky competitive networks to mimic symbolic models of heuristic choice suggests that these 2 approaches are not incompatible, and that a unitary cognitive model of preferential choice, based on insights from both these approaches, may be feasible. PMID:28670592

  14. Sleep facilitates learning a new linguistic rule.

    PubMed

    Batterink, Laura J; Oudiette, Delphine; Reber, Paul J; Paller, Ken A

    2014-12-01

    Natural languages contain countless regularities. Extraction of these patterns is an essential component of language acquisition. Here we examined the hypothesis that memory processing during sleep contributes to this learning. We exposed participants to a hidden linguistic rule by presenting a large number of two-word phrases, each including a noun preceded by one of four novel words that functioned as an article (e.g., gi rhino). These novel words (ul, gi, ro and ne) were presented as obeying an explicit rule: two words signified that the noun referent was relatively near, and two that it was relatively far. Undisclosed to participants was the fact that the novel articles also predicted noun animacy, with two of the articles preceding animate referents and the other two preceding inanimate referents. Rule acquisition was tested implicitly using a task in which participants responded to each phrase according to whether the noun was animate or inanimate. Learning of the hidden rule was evident in slower responses to phrases that violated the rule. Responses were delayed regardless of whether rule-knowledge was consciously accessible. Brain potentials provided additional confirmation of implicit and explicit rule-knowledge. An afternoon nap was interposed between two 20-min learning sessions. Participants who obtained greater amounts of both slow-wave and rapid-eye-movement sleep showed increased sensitivity to the hidden linguistic rule in the second session. We conclude that during sleep, reactivation of linguistic information linked with the rule was instrumental for stabilizing learning. The combination of slow-wave and rapid-eye-movement sleep may synergistically facilitate the abstraction of complex patterns in linguistic input. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Sleep facilitates learning a new linguistic rule

    PubMed Central

    Batterink, Laura J.; Oudiette, Delphine; Reber, Paul J.; Paller, Ken A.

    2014-01-01

    Natural languages contain countless regularities. Extraction of these patterns is an essential component of language acquisition. Here we examined the hypothesis that memory processing during sleep contributes to this learning. We exposed participants to a hidden linguistic rule by presenting a large number of two-word phrases, each including a noun preceded by one of four novel words that functioned as an article (e.g., gi rhino). These novel words (ul, gi, ro and ne) were presented as obeying an explicit rule: two words signified that the noun referent was relatively near, and two that it was relatively far. Undisclosed to participants was the fact that the novel articles also predicted noun animacy, with two of the articles preceding animate referents and the other two preceding inanimate referents. Rule acquisition was tested implicitly using a task in which participants responded to each phrase according to whether the noun was animate or inanimate. Learning of the hidden rule was evident in slower responses to phrases that violated the rule. Responses were delayed regardless of whether rule-knowledge was consciously accessible. Brain potentials provided additional confirmation of implicit and explicit rule-knowledge. An afternoon nap was interposed between two 20-min learning sessions. Participants who obtained greater amounts of both slow-wave and rapid-eye-movement sleep showed increased sensitivity to the hidden linguistic rule in the second session. We conclude that during sleep, reactivation of linguistic information linked with the rule was instrumental for stabilizing learning. The combination of slow-wave and rapid-eye-movement sleep may synergistically facilitate the abstraction of complex patterns in linguistic input. PMID:25447376

  16. 18 CFR 385.104 - Rule of construction (Rule 104).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Rule of construction (Rule 104). 385.104 Section 385.104 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Definitions § 385.104 Rule of construction (Rule 104). To the extent that the text of a rule is inconsistent...

  17. 18 CFR 385.104 - Rule of construction (Rule 104).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Rule of construction (Rule 104). 385.104 Section 385.104 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Definitions § 385.104 Rule of construction (Rule 104). To the extent that the text of a rule is inconsistent...

  18. Variations among Adults in Their Use of Morphemic Spelling Rules and Word-Specific Knowledge when Spelling

    ERIC Educational Resources Information Center

    Mitchell, Paul; Kemp, Nenagh; Bryant, Peter

    2011-01-01

    The purpose of this research was to examine whether adults rely on morphemic spelling rules or word-specific knowledge when spelling simple words. We examined adults' knowledge of two of the simplest and most reliable rules in English spelling concerning the morphological word ending -s. This spelling is required for regular plural nouns (e.g.,…

  19. Phonological reduplication in sign language: Rules rule

    PubMed Central

    Berent, Iris; Dupuis, Amanda; Brentari, Diane

    2014-01-01

    Productivity—the hallmark of linguistic competence—is typically attributed to algebraic rules that support broad generalizations. Past research on spoken language has documented such generalizations in both adults and infants. But whether algebraic rules form part of the linguistic competence of signers remains unknown. To address this question, here we gauge the generalization afforded by American Sign Language (ASL). As a case study, we examine reduplication (X→XX)—a rule that, inter alia, generates ASL nouns from verbs. If signers encode this rule, then they should freely extend it to novel syllables, including ones with features that are unattested in ASL. And since reduplicated disyllables are preferred in ASL, such a rule should favor novel reduplicated signs. Novel reduplicated signs should thus be preferred to nonreduplicative controls (in rating), and consequently, such stimuli should also be harder to classify as nonsigns (in the lexical decision task). The results of four experiments support this prediction. These findings suggest that the phonological knowledge of signers includes powerful algebraic rules. The convergence between these conclusions and previous evidence for phonological rules in spoken language suggests that the architecture of the phonological mind is partly amodal. PMID:24959158

  20. Factors related to the involvement of nurses in medical end-of-life decisions in Belgium: a death certificate study.

    PubMed

    Inghelbrecht, Els; Bilsen, Johan; Mortier, Freddy; Deliens, Luc

    2008-07-01

    Although nurses play an important role in end-of-life care for patients, they are not systematically involved in end-of-life decisions with a possible or certain life-shortening effect (ELDs). Until now we know little about factors relating to the involvement of nurses in these decisions. To explore which patient- and decision-characteristics are related to the consultation of nurses and to the administering of life-ending drugs by nurses in actual ELDs in institutions and home care, as reported by physicians. We sampled at random 5005 of all registered deaths in the second half of 2001--before euthanasia was legalized--in Flanders, Belgium. We mailed anonymous questionnaires to physicians who signed the death certificates and asked them to report on ELDs, including nurses' involvement. Response rate was 59% (n=2950). Physicians reported nurses involved in decision making more often in institutions than at home, and more often in care homes for the elderly than in hospitals (OR 1.70, 95% CI 1.15, 2.52). This involvement was more frequently when physicians intended to hasten the patient's death than when they had no such intention (institutions: OR 2.05, 95% CI 1.41, 2.99; home: OR 2.04, 95% CI 1.19, 3.49). In institutions, this involvement was also more likely where patients were of lower rather than higher education (OR 2.95, 95% CI 1.49, 5.84). The administering of life-ending drugs by nurses, as reported by physicians was also found more frequently in institutions than at home, and in institutions more frequently with lower rather than higher educated patients (p=.037). These findings raise questions about physicians' perception of the nurse's role in ELDs, but also about physicians' skills in interacting with all patients. Education and guidelines for physicians and nurses are needed to optimize good communication and to promote a clearer assignment of responsibilities concerning the execution of those decisions.

  1. Optimization of multi response in end milling process of ASSAB XW-42 tool steel with liquid nitrogen cooling using Taguchi-grey relational analysis

    NASA Astrophysics Data System (ADS)

    Norcahyo, Rachmadi; Soepangkat, Bobby O. P.

    2017-06-01

    A research was conducted for the optimization of the end milling process of ASSAB XW-42 tool steel with multiple performance characteristics based on the orthogonal array with Taguchi-grey relational analysis method. Liquid nitrogen was applied as a coolant. The experimental studies were conducted under varying the liquid nitrogen cooling flow rates (FL), and the end milling process variables, i.e., cutting speed (Vc), feeding speed (Vf), and axial depth of cut (Aa). The optimized multiple performance characteristics were surface roughness (SR), flank wear (VB), and material removal rate (MRR). An orthogonal array, signal-to-noise (S/N) ratio, grey relational analysis, grey relational grade, and analysis of variance were employed to study the multiple performance characteristics. Experimental results showed that flow rate gave the highest contribution for reducing the total variation of the multiple responses, followed by cutting speed, feeding speed, and axial depth of cut. The minimum surface roughness, flank wear, and maximum material removal rate could be obtained by using the values of flow rate, cutting speed, feeding speed, and axial depth of cut of 0.5 l/minute, 109.9 m/minute, 440 mm/minute, and 0.9 mm, respectively.

  2. 29 CFR 1921.1 - Applicability of rules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Longshoremen's and Harbor Workers' Compensation Act and the safety regulations promulgated thereunder which are... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... WORKERS' COMPENSATION ACT Applicability of Rules; Definitions § 1921.1 Applicability of rules. This part...

  3. End stage renal disease in French Guiana (data from R.E.I.N registry): South American or French?

    PubMed

    Rochemont, Dévi Rita; Meddeb, Mohamed; Roura, Raoul; Couchoud, Cécile; Nacher, Mathieu; Basurko, Célia

    2017-06-30

    End-Stage renal disease (ESRD) causes considerable morbidity and mortality, and significantly alters patients' quality of life. There are very few published data on this problem in the French Overseas territories. The development of a registry on end stage renal disease in French Guiana in 2011 allowed to describe the magnitude of this problem in the region for the first time. Using data from the French Renal Epidemiology and Information Network registry (R.E.I.N). Descriptive statistics on quantitative and qualitative variables in the registry were performed on prevalent cases and incident cases in 2011, 2012 and 2013. French Guiana has one of the highest ESRD prevalence and incidence in France. The two main causes of ESRD were hypertensive and diabetic nephropathies. The French Guianese population had a different demographic profile (younger, more women, more migrants) than in mainland France. Most patients had at least one comorbidity, predominantly (95.3%) hypertension. In French Guiana dialysis was initiated in emergency for 71.3% of patients versus 33% in France (p < 0.001). These first results give important public health information: i) End stage renal disease has a very high prevalence relative to mainland France ii) Patients have a different demographic profile and enter care late in the course of their renal disease. These data are closer to what is observed in the Caribbean or in Latin America than in Mainland France.

  4. A Performance Comparison Study of Uncoated and TiAlN Coated Carbide End Mill on Machining of the Al-35Zn Alloy

    NASA Astrophysics Data System (ADS)

    Bayraktar, S.; Hekimoglu, A. P.; Turgut, Y.; Haciosmanoglu, M.

    2018-01-01

    In this study, Al-35Zn alloy was produced by permanent mold casting. To investigate the cutting performance of uncoated and TiAlN coated carbide end mills on this alloy, a series of tests were carried out in the CNC vertical machining center at a constant cutting speed, feed rate and depth of cut. The results obtained from the tests showed that uncoated carbide end mill have lower cutting force and surface roughness than TiAlN coated carbide end mill. These observations are discussed in terms of the alloys properties, cutting tool surfaces, and friction and wear behavior between the cutting tool and the material.

  5. Comparing T-odd and T-even spin sum rules

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Teryaev, O.V.

    2015-04-10

    Sum rules for T-even and T-odd structure functions and parton distributions are considered. The case of spin-dependent distributions related to energy-momentum tensor (EMT) is specifically addressed. The Burkardt sum rule for T-odd Sivers functions may be related to EMT provided the imaginary prescription for gluonic pole correlator is incorporated. The momentum sum rule for deuteron tensor spin structure function allows one to probe indirectly the gravity couplings to quarks and gluons.

  6. Generating Concise Rules for Human Motion Retrieval

    NASA Astrophysics Data System (ADS)

    Mukai, Tomohiko; Wakisaka, Ken-Ichi; Kuriyama, Shigeru

    This paper proposes a method for retrieving human motion data with concise retrieval rules based on the spatio-temporal features of motion appearance. Our method first converts motion clip into a form of clausal language that represents geometrical relations between body parts and their temporal relationship. A retrieval rule is then learned from the set of manually classified examples using inductive logic programming (ILP). ILP automatically discovers the essential rule in the same clausal form with a user-defined hypothesis-testing procedure. All motions are indexed using this clausal language, and the desired clips are retrieved by subsequence matching using the rule. Such rule-based retrieval offers reasonable performance and the rule can be intuitively edited in the same language form. Consequently, our method enables efficient and flexible search from a large dataset with simple query language.

  7. Preschoolers can infer general rules governing fantastical events in fiction.

    PubMed

    Van de Vondervoort, Julia W; Friedman, Ori

    2014-05-01

    Young children are frequently exposed to fantastic fiction. How do they make sense of the unrealistic and impossible events that occur in such fiction? Although children could view such events as isolated episodes, the present experiments suggest that children use such events to infer general fantasy rules. In 2 experiments, 2- to 4-year-olds were shown scenarios in which 2 animals behaved unrealistically (N = 78 in Experiment 1, N = 94 in Experiment 2). When asked to predict how other animals in the fiction would behave, children predicted novel behaviors consistent with the nature of the fiction. These findings suggest that preschoolers can infer the general rules that govern the events and entities in fantastic fiction and can use these rules to predict what events will happen in the fiction. The findings also provide evidence that children may infer fantasy rules at a more superordinate level than the basic level. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  8. Comparison of Direct Side-to-End and End-to-End Hypoglossal-Facial Anastomosis for Facial Nerve Repair.

    PubMed

    Samii, Madjid; Alimohamadi, Maysam; Khouzani, Reza Karimi; Rashid, Masoud Rafizadeh; Gerganov, Venelin

    2015-08-01

    The hypoglossal facial anastomosis (HFA) is the gold standard for facial reanimation in patients with severe facial nerve palsy. The major drawbacks of the classic HFA technique are lingual morbidities due to hypoglossal nerve transection. The side-to-end HFA is a modification of the classic technique with fewer tongue-related morbidities. In this study we compared the outcome of the classic end-to-end and the direct side-to-end HFA surgeries performed at our center in regards to the facial reanimation success rate and tongue-related morbidities. Twenty-six successive cases of HFA were enrolled. In 9 of them end-to-end anastomoses were performed, and 17 had direct side-to-end anastomoses. The House-Brackmann (HB) and Pitty and Tator (PT) scales were used to document surgical outcome. The hemiglossal atrophy, swallowing, and hypoglossal nerve function were assessed at follow-up. The original pathology was vestibular schwannoma in 15, meningioma in 4, brain stem glioma in 4, and other pathologies in 3. The mean interval between facial palsy and HFA was 18 months (range: 0-60). The median follow-up period was 20 months. The PT grade at follow-up was worse in patients with a longer interval from facial palsy and HFA (P value: 0.041). The lesion type was the only other factor that affected PT grade (the best results in vestibular schwannoma and the worst in the other pathologies group, P value: 0.038). The recovery period for facial tonicity was longer in patients with radiation therapy before HFA (13.5 vs. 8.5 months) and those with a longer than 2-year interval from facial palsy to HFA (13.5 vs. 8.5 months). Although no significant difference between the side-to-end and the end-to-end groups was seen in terms of facial nerve functional recovery, patients from the side-to-end group had a significantly lower rate of lingual morbidities (tongue hemiatrophy: 100% vs. 5.8%, swallowing difficulty: 55% vs. 11.7%, speech disorder 33% vs. 0%). With the side-to-end HFA

  9. The optimum decision rules for the oddity task.

    PubMed

    Versfeld, N J; Dai, H; Green, D M

    1996-01-01

    This paper presents the optimum decision rule for an m-interval oddity task in which m-1 intervals contain the same signal and one is different or odd. The optimum decision rule depends on the degree of correlation among observations. The present approach unifies the different strategies that occur with "roved" or "fixed" experiments (Macmillan & Creelman, 1991, p. 147). It is shown that the commonly used decision rule for an m-interval oddity task corresponds to the special case of highly correlated observations. However, as is also true for the same-different paradigm, there exists a different optimum decision rule when the observations are independent. The relation between the probability of a correct response and d' is derived for the three-interval oddity task. Tables are presented of this relation for the three-, four-, and five-interval oddity task. Finally, an experimental method is proposed that allows one to determine the decision rule used by the observer in an oddity experiment.

  10. On nonstationarity-related errors in modal combination rules of the response spectrum method

    NASA Astrophysics Data System (ADS)

    Pathak, Shashank; Gupta, Vinay K.

    2017-10-01

    Characterization of seismic hazard via (elastic) design spectra and the estimation of linear peak response of a given structure from this characterization continue to form the basis of earthquake-resistant design philosophy in various codes of practice all over the world. Since the direct use of design spectrum ordinates is a preferred option for the practicing engineers, modal combination rules play central role in the peak response estimation. Most of the available modal combination rules are however based on the assumption that nonstationarity affects the structural response alike at the modal and overall response levels. This study considers those situations where this assumption may cause significant errors in the peak response estimation, and preliminary models are proposed for the estimation of the extents to which nonstationarity affects the modal and total system responses, when the ground acceleration process is assumed to be a stationary process. It is shown through numerical examples in the context of complete-quadratic-combination (CQC) method that the nonstationarity-related errors in the estimation of peak base shear may be significant, when strong-motion duration of the excitation is too small compared to the period of the system and/or the response is distributed comparably in several modes. It is also shown that these errors are reduced marginally with the use of the proposed nonstationarity factor models.

  11. Interrelationships Between Receiver/Relative Operating Characteristics Display, Binomial, Logit, and Bayes' Rule Probability of Detection Methodologies

    NASA Technical Reports Server (NTRS)

    Generazio, Edward R.

    2014-01-01

    Unknown risks are introduced into failure critical systems when probability of detection (POD) capabilities are accepted without a complete understanding of the statistical method applied and the interpretation of the statistical results. The presence of this risk in the nondestructive evaluation (NDE) community is revealed in common statements about POD. These statements are often interpreted in a variety of ways and therefore, the very existence of the statements identifies the need for a more comprehensive understanding of POD methodologies. Statistical methodologies have data requirements to be met, procedures to be followed, and requirements for validation or demonstration of adequacy of the POD estimates. Risks are further enhanced due to the wide range of statistical methodologies used for determining the POD capability. Receiver/Relative Operating Characteristics (ROC) Display, simple binomial, logistic regression, and Bayes' rule POD methodologies are widely used in determining POD capability. This work focuses on Hit-Miss data to reveal the framework of the interrelationships between Receiver/Relative Operating Characteristics Display, simple binomial, logistic regression, and Bayes' Rule methodologies as they are applied to POD. Knowledge of these interrelationships leads to an intuitive and global understanding of the statistical data, procedural and validation requirements for establishing credible POD estimates.

  12. 17 CFR 12.300 - Scope and applicability of rules.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Scope and applicability of rules. 12.300 Section 12.300 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES RELATING TO REPARATIONS Rules Applicable to Formal Decisional Proceedings § 12.300 Scope and...

  13. Random walkers with extreme value memory: modelling the peak-end rule

    NASA Astrophysics Data System (ADS)

    Harris, Rosemary J.

    2015-05-01

    Motivated by the psychological literature on the ‘peak-end rule’ for remembered experience, we perform an analysis within a random walk framework of a discrete choice model where agents’ future choices depend on the peak memory of their past experiences. In particular, we use this approach to investigate whether increased noise/disruption always leads to more switching between decisions. Here extreme value theory illuminates different classes of dynamics indicating that the long-time behaviour is dependent on the scale used for reflection; this could have implications, for example, in questionnaire design.

  14. Rule groupings: A software engineering approach towards verification of expert systems

    NASA Technical Reports Server (NTRS)

    Mehrotra, Mala

    1991-01-01

    Currently, most expert system shells do not address software engineering issues for developing or maintaining expert systems. As a result, large expert systems tend to be incomprehensible, difficult to debug or modify and almost impossible to verify or validate. Partitioning rule based systems into rule groups which reflect the underlying subdomains of the problem should enhance the comprehensibility, maintainability, and reliability of expert system software. Attempts were made to semiautomatically structure a CLIPS rule base into groups of related rules that carry the same type of information. Different distance metrics that capture relevant information from the rules for grouping are discussed. Two clustering algorithms that partition the rule base into groups of related rules are given. Two independent evaluation criteria are developed to measure the effectiveness of the grouping strategies. Results of the experiment with three sample rule bases are presented.

  15. Improve Tracking of Workplace Injuries and Illnesses. Final rule.

    PubMed

    2016-05-12

    OSHA is issuing a final rule to revise its Recording and Reporting Occupational Injuries and Illnesses regulation. The final rule requires employers in certain industries to electronically submit to OSHA injury and illness data that employers are already required to keep under existing OSHA regulations. The frequency and content of these establishment-specific submissions is set out in the final rule and is dependent on the size and industry of the employer. OSHA intends to post the data from these submissions on a publicly accessible Web site. OSHA does not intend to post any information on the Web site that could be used to identify individual employees. The final rule also amends OSHA's recordkeeping regulation to update requirements on how employers inform employees to report work-related injuries and illnesses to their employer. The final rule requires employers to inform employees of their right to report work-related injuries and illnesses free from retaliation; clarifies the existing implicit requirement that an employer's procedure for reporting work-related injuries and illnesses must be reasonable and not deter or discourage employees from reporting; and incorporates the existing statutory prohibition on retaliating against employees for reporting work-related injuries or illnesses. The final rule also amends OSHA's existing recordkeeping regulation to clarify the rights of employees and their representatives to access the injury and illness records.

  16. Adaptive decision rules for the acquisition of nature reserves.

    PubMed

    Turner, Will R; Wilcove, David S

    2006-04-01

    Although reserve-design algorithms have shown promise for increasing the efficiency of conservation planning, recent work casts doubt on the usefulness of some of these approaches in practice. Using three data sets that vary widely in size and complexity, we compared various decision rules for acquiring reserve networks over multiyear periods. We explored three factors that are often important in real-world conservation efforts: uncertain availability of sites for acquisition, degradation of sites, and overall budget constraints. We evaluated the relative strengths and weaknesses of existing optimal and heuristic decision rules and developed a new set of adaptive decision rules that combine the strengths of existing optimal and heuristic approaches. All three of the new adaptive rules performed better than the existing rules we tested under virtually all scenarios of site availability, site degradation, and budget constraints. Moreover, the adaptive rules required no additional data beyond what was readily available and were relatively easy to compute.

  17. RuleMonkey: software for stochastic simulation of rule-based models

    PubMed Central

    2010-01-01

    Background The system-level dynamics of many molecular interactions, particularly protein-protein interactions, can be conveniently represented using reaction rules, which can be specified using model-specification languages, such as the BioNetGen language (BNGL). A set of rules implicitly defines a (bio)chemical reaction network. The reaction network implied by a set of rules is often very large, and as a result, generation of the network implied by rules tends to be computationally expensive. Moreover, the cost of many commonly used methods for simulating network dynamics is a function of network size. Together these factors have limited application of the rule-based modeling approach. Recently, several methods for simulating rule-based models have been developed that avoid the expensive step of network generation. The cost of these "network-free" simulation methods is independent of the number of reactions implied by rules. Software implementing such methods is now needed for the simulation and analysis of rule-based models of biochemical systems. Results Here, we present a software tool called RuleMonkey, which implements a network-free method for simulation of rule-based models that is similar to Gillespie's method. The method is suitable for rule-based models that can be encoded in BNGL, including models with rules that have global application conditions, such as rules for intramolecular association reactions. In addition, the method is rejection free, unlike other network-free methods that introduce null events, i.e., steps in the simulation procedure that do not change the state of the reaction system being simulated. We verify that RuleMonkey produces correct simulation results, and we compare its performance against DYNSTOC, another BNGL-compliant tool for network-free simulation of rule-based models. We also compare RuleMonkey against problem-specific codes implementing network-free simulation methods. Conclusions RuleMonkey enables the simulation of

  18. Board of Veterans' Appeals: rules of practice--notice of appeal in simultaneously contested claim. Final rule.

    PubMed

    2001-12-03

    The Board of Veterans' Appeals (Board) adjudicates appeals from denials of claims for veterans' benefits filed with the Department of Veterans Affairs (VA). This document amends a Board Rule of Practice, pertaining to a type of notice given in simultaneously contested claim appeals, to eliminate an inconsistency between that Rule of Practice and an Appeals Regulation and to update a presumption related to communication of the notice.

  19. 12 CFR Optional Annual Percentage... - End Plans Subject to the Requirements of § 226.5b

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....5b Annual Optional Annual Percentage Rate Computations for Creditors Offering Open Banks and Banking... (REGULATION Z) Special Rules Applicable to Credit Card Accounts and Open-End Credit Offered to College... Creditors Offering Open-End Plans Subject to the Requirements of § 226.5b In determining the denominator of...

  20. 12 CFR Optional Annual Percentage... - End Plans Subject to the Requirements of § 226.5b

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....5b Annual Optional Annual Percentage Rate Computations for Creditors Offering Open Banks and Banking... (REGULATION Z) Special Rules Applicable to Credit Card Accounts and Open-End Credit Offered to College... Creditors Offering Open-End Plans Subject to the Requirements of § 226.5b In determining the denominator of...

  1. 12 CFR Optional Annual Percentage... - End Plans Subject to the Requirements of § 226.5b

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....5b Annual Optional Annual Percentage Rate Computations for Creditors Offering Open Banks and Banking... LENDING (REGULATION Z) Special Rules Applicable to Credit Card Accounts and Open-End Credit Offered to... Computations for Creditors Offering Open-End Plans Subject to the Requirements of § 226.5b In determining the...

  2. When you shouldn't do what you want to do: young children's understanding of desires, rules, and emotions.

    PubMed

    Lagattuta, Kristin Hansen

    2005-01-01

    This research investigated 4- through 7-year-olds' and adults' (n = 64) concepts about the emotional consequences of desire fulfillment versus desire inhibition in situations where people's desires conflict with prohibitive rules. Results revealed developmental increases in attributing positive or mixed emotions to story characters that make willpower decisions and negative or mixed emotions to characters that transgress. These developmental changes in emotion predictions were accompanied by age-related differences in emotion explanations. Whereas 4- and 5-year-olds largely explained emotions in relation to the characters' goals, 7-year-olds and adults further explained how rules and future consequences influence emotions. Results are discussed in relation to connections among children's psychological, deontic, and future-oriented reasoning about emotions as well as the development of self-control.

  3. 4 CFR 22.1 - Applicability of Rules [Rule 1].

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Applicability of Rules [Rule 1]. 22.1 Section 22.1... ACCOUNTABILITY OFFICE CONTRACT APPEALS BOARD § 22.1 Applicability of Rules [Rule 1]. The Government... all appeals filed with the Board on or after October 1, 2007. ...

  4. Parental Practices and Attitudes Related to Smoke-Free Rules in Homes, Cars, and Outdoor Playgrounds in US Households With Underage Children and Smokers, 2010-2011.

    PubMed

    Zhang, Xiao; Martinez-Donate, Ana; Rhoads, Natalie

    2015-06-18

    A smoke-free environment protects children from exposure to involuntary smoke and also can reduce or prevent future smoking behavior. The purpose of this study was to examine levels and correlates of parental behavior and attitudes related to voluntary smoke-free rules in homes, cars, and outdoor children's play areas among US households with underage children and 1 or more smoking parents. We used data from the 2010-2011 Tobacco Use Supplement to the Current Population Survey and logistic regressions to model behavior and attitudes related to voluntary smoke-free rules in 3 settings. Overall, 60.1% of households with children and at least 1 smoking parent had voluntary smoke-free home rules. Approximately 84.6% and 71.5% of parents thought that smoking should not be allowed inside cars with children present and in outdoor play areas, respectively. Positive parental behavior and attitudes related to voluntary smoke-free rules were more likely among households with 2 parents, parents of higher education and household income, Hispanic parents, and parents of infants (P < .05). Tobacco control and prevention efforts are needed to promote the voluntary adoption of smoke-free rules in homes, private cars, and outdoor children's play areas. Most parents from smoker households with underage children were supportive of smoke-free laws for cars and outdoor children's play areas, providing evidence and encouragement to policy makers to take action to restrict smoking in these locations.

  5. Slide Esophagoplasty vs End-to-End Anastomosis for Recalcitrant Esophageal Stricture after Esophageal Atresia Repair.

    PubMed

    Kamran, Ali; Smithers, Charles J; Manfredi, Michael A; Hamilton, Thomas E; Ngo, Peter D; Zurakowski, David; Jennings, Russell W

    2018-06-01

    Anastomotic stricture is a common complication after esophageal atresia (EA) repair. Patients with a recalcitrant stricture may require surgical intervention. The technique of reanastomosis after stricture resection can affect patient outcomes. Patients with EA who underwent anastomotic stricture resection, from July 2010 to February 2017, were reviewed. After stricture resection, patients who had slide esophagoplasty performed were compared with those having conventional end-to-end anastomosis. Fifty patients underwent stricture repair surgery by slide esophagoplasty (n = 12) or end-to-end (n = 38) anastomosis technique at a median age of 14 months (interquartile range [IQR] 6 to 23 months). Significantly fewer patients required dilation therapy after slide esophagoplasty: 6 of 12 (50%) compared with 32 of 38 (84%) in the end-to-end group (p = 0.02). The number of dilation sessions was significantly lower in the slide group vs the end-to-end (p = 0.004) group, with a risk ratio confirming the approximately half the number of dilations for the slide approach (risk ratio 0.57, 95% CI 0.38 to 0.86). Steroid injection was combined with dilation in 3 of 12 (25%) vs 22 of 38 (58%) in the slide and end-to-end groups, respectively (p = 0.10). Stent placement was used in none of slide cases vs 8 of 38 (21%) in the end-to-end group (p = 0.17). Stricture incision was performed in 1 of 12 (8%) in the slide group and 11 of 38 (29%) in the end-to-end group (p = 0.25). There were leak complications in fewer patients after slide esophagoplasty compared with end-to-end anastomosis: 1 of 12 (8%) vs 8 of 38 (21%) (p = 0.43). Slide esophagoplasty may be a useful technique of anastomotic configuration for selected patients with recalcitrant esophageal stricture, offering more favorable outcomes compared with end-to-end anastomosis. Copyright © 2017 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  6. Executive Control Over Cognition: Stronger and Earlier Rule-Based Modulation of Spatial Category Signals in Prefrontal Cortex Relative to Parietal Cortex

    PubMed Central

    Goodwin, Shikha J.; Blackman, Rachael K.; Sakellaridi, Sofia

    2012-01-01

    Human cognition is characterized by flexibility, the ability to select not only which action but which cognitive process to engage to best achieve the current behavioral objective. The ability to tailor information processing in the brain to rules, goals, or context is typically referred to as executive control, and although there is consensus that prefrontal cortex is importantly involved, at present we have an incomplete understanding of how computational flexibility is implemented at the level of prefrontal neurons and networks. To better understand the neural mechanisms of computational flexibility, we simultaneously recorded the electrical activity of groups of single neurons within prefrontal and posterior parietal cortex of monkeys performing a task that required executive control of spatial cognitive processing. In this task, monkeys applied different spatial categorization rules to reassign the same set of visual stimuli to alternative categories on a trial-by-trial basis. We found that single neurons were activated to represent spatially defined categories in a manner that was rule dependent, providing a physiological signature of a cognitive process that was implemented under executive control. We found also that neural signals coding rule-dependent categories were distributed between the parietal and prefrontal cortex—however, not equally. Rule-dependent category signals were stronger, more powerfully modulated by the rule, and earlier to emerge in prefrontal cortex relative to parietal cortex. This suggests that prefrontal cortex may initiate the switch in neural representation at a network level that is important for computational flexibility. PMID:22399773

  7. Peak and end effects in patients' daily recall of pain and fatigue: a within-subjects analysis.

    PubMed

    Schneider, Stefan; Stone, Arthur A; Schwartz, Joseph E; Broderick, Joan E

    2011-02-01

    Clinical research often relies on retrospective recall of symptom levels, but the information contained in these ratings is not well understood. The "peak-and-end rule" suggests that the most intense (peak) and final (end) moments of an experience disproportionately influence retrospective judgments, which may bias self-reports of somatic symptoms. This study examined the extent to which peak and end symptom levels systematically affect patients' day-to-day recall of pain and fatigue. Rheumatology patients (N = 97) completed 5 to 6 momentary ratings of pain and fatigue per day as well as a daily recall rating of these symptoms for 28 consecutive days. For pain, peak and end momentary ratings predicted daily recall of average pain beyond the actual average of momentary ratings. This effect was small, yet was confirmed in both between-person and within-person (repeated measures) analyses. For fatigue, neither peak nor end momentary symptoms significantly contributed to daily recall. Of note, the evidence for peak- and end-effects in recall of pain and fatigue varied significantly between individual patients. These findings suggest that peak- and end-effects create a small bias in recall reports of pain, but not fatigue. However, there are considerable individual differences in susceptibility to peak and end heuristics. The peak-end cognitive heuristic could bias end-of-day recall of pain and fatigue. An effect was shown for pain, but not for fatigue. The effects were small and were unlikely to substantially bias end-of-day assessments. Individuals were shown to differ in the degree that the heuristic was associated with recall. Copyright © 2011 American Pain Society. Published by Elsevier Inc. All rights reserved.

  8. Organizational Knowledge Transfer Using Ontologies and a Rule-Based System

    NASA Astrophysics Data System (ADS)

    Okabe, Masao; Yoshioka, Akiko; Kobayashi, Keido; Yamaguchi, Takahira

    In recent automated and integrated manufacturing, so-called intelligence skill is becoming more and more important and its efficient transfer to next-generation engineers is one of the urgent issues. In this paper, we propose a new approach without costly OJT (on-the-job training), that is, combinational usage of a domain ontology, a rule ontology and a rule-based system. Intelligence skill can be decomposed into pieces of simple engineering rules. A rule ontology consists of these engineering rules as primitives and the semantic relations among them. A domain ontology consists of technical terms in the engineering rules and the semantic relations among them. A rule ontology helps novices get the total picture of the intelligence skill and a domain ontology helps them understand the exact meanings of the engineering rules. A rule-based system helps domain experts externalize their tacit intelligence skill to ontologies and also helps novices internalize them. As a case study, we applied our proposal to some actual job at a remote control and maintenance office of hydroelectric power stations in Tokyo Electric Power Co., Inc. We also did an evaluation experiment for this case study and the result supports our proposal.

  9. 18 CFR 385.103 - References to rules (Rule 103).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false References to rules (Rule 103). 385.103 Section 385.103 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Definitions § 385.103 References to rules (Rule 103). This part cross-references its sections according to...

  10. 18 CFR 385.103 - References to rules (Rule 103).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false References to rules (Rule 103). 385.103 Section 385.103 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Definitions § 385.103 References to rules (Rule 103). This part cross-references its sections according to...

  11. Analysis of the relationship between end-to-end distance and activity of single-chain antibody against colorectal carcinoma.

    PubMed

    Zhang, Jianhua; Liu, Shanhong; Shang, Zhigang; Shi, Li; Yun, Jun

    2012-08-22

    We investigated the relationship of End-to-end distance between VH and VL with different peptide linkers and the activity of single-chain antibodies by computer-aided simulation. First, we developed (G4S)n (where n = 1-9) as the linker to connect VH and VL, and estimated the 3D structure of single-chain Fv antibody (scFv) by homologous modeling. After molecular models were evaluated and optimized, the coordinate system of every protein was built and unified into one coordinate system, and End-to-end distances calculated using 3D space coordinates. After expression and purification of scFv-n with (G4S)n as n = 1, 3, 5, 7 or 9, the immunoreactivity of purified ND-1 scFv-n was determined by ELISA. A multi-factorial relationship model was employed to analyze the structural factors affecting scFv: rn=ABn-ABO2+CDn-CDO2+BCn-BCst2. The relationship between immunoreactivity and r-values revealed that fusion protein structure approached the desired state when the r-value = 3. The immunoreactivity declined as the r-value increased, but when the r-value exceeded a certain threshold, it stabilized. We used a linear relationship to analyze structural factors affecting scFv immunoreactivity.

  12. End-of-life care communications and shared decision-making in Norwegian nursing homes--experiences and perspectives of patients and relatives.

    PubMed

    Gjerberg, Elisabeth; Lillemoen, Lillian; Førde, Reidun; Pedersen, Reidar

    2015-08-19

    Involving nursing home patients and their relatives in end-of-life care conversations and treatment decisions has recently gained increased importance in several Western countries. However, there is little knowledge about how the patients themselves and their next-of-kin look upon involvement in end-of-life care decisions. The purpose of this paper is to explore nursing home patients' and next-of-kin's experiences with- and perspectives on end-of-life care conversations, information and shared decision-making. The study has a qualitative and explorative design, based on a combination of individual interviews with 35 patients living in six nursing homes and seven focus group interviews with 33 relatives. The data was analysed applying a "bricolage" approach". Participation was based on informed consent, and the study was approved by the Regional Committees for Medical and Health Research Ethics. Few patients and relatives had participated in conversations about end-of-life care. Most relatives wanted such conversations, while the patients' opinions varied. With some exceptions, patients and relatives wanted to be informed about the patient's health condition. The majority wanted to be involved in the decision-making process, but leave the final decisions to the health professionals. Among the patients, the opinion varied; some patients wanted to leave the decisions more or less completely to the nursing home staff. Conversations about end-of-life care issues are emotionally challenging, and very few patients had discussed these questions with their family. The relatives' opinions of the patient's preferences were mainly based on assumptions; they had seldom talked about this explicitly. Both patients and relatives wanted the staff to raise these questions. Nursing home staff should initiate conversations about preferences for end-of-life care, assisting patients and relatives in talking about these issues, while at the same time being sensitive to the diversity in

  13. Kuramoto model with uniformly spaced frequencies: Finite-N asymptotics of the locking threshold.

    PubMed

    Ottino-Löffler, Bertrand; Strogatz, Steven H

    2016-06-01

    We study phase locking in the Kuramoto model of coupled oscillators in the special case where the number of oscillators, N, is large but finite, and the oscillators' natural frequencies are evenly spaced on a given interval. In this case, stable phase-locked solutions are known to exist if and only if the frequency interval is narrower than a certain critical width, called the locking threshold. For infinite N, the exact value of the locking threshold was calculated 30 years ago; however, the leading corrections to it for finite N have remained unsolved analytically. Here we derive an asymptotic formula for the locking threshold when N≫1. The leading correction to the infinite-N result scales like either N^{-3/2} or N^{-1}, depending on whether the frequencies are evenly spaced according to a midpoint rule or an end-point rule. These scaling laws agree with numerical results obtained by Pazó [D. Pazó, Phys. Rev. E 72, 046211 (2005)PLEEE81539-375510.1103/PhysRevE.72.046211]. Moreover, our analysis yields the exact prefactors in the scaling laws, which also match the numerics.

  14. 75 FR 34626 - Rules and Regulations for Abandoned Individual Account Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ... DEPARTMENT OF LABOR Employee Benefits Security Administration 29 CFR Part 2578 Rules and Regulations for Abandoned Individual Account Plans CFR Correction In Title 29 of the Code of Federal Regulations, Part 1927 to End, revised as of July 1, 2009, on pages 664 and 665, remove the second Appendix C...

  15. 29 CFR 825.400 - Enforcement, general rules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Enforcement, general rules. 825.400 Section 825.400 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Enforcement Mechanisms § 825.400 Enforcement, general rules. (a) The...

  16. Empirical electronic polarizabilities: deviations from the additivity rule. I. M2+SO4·nH2O, blödite Na2M2+(SO4)2·4H2O, and kieserite-related minerals with sterically strained structures

    NASA Astrophysics Data System (ADS)

    Gagné, Olivier; Hawthorne, Frank; Shannon, Robert D.; Fischer, Reinhard X.

    2017-09-01

    Empirical electronic polarizabilities allow the prediction of total mineral polarizabilities and mean refractive indices of the vast majority of minerals and synthetic oxides. However, deviations from the valence-sum rule at cations in some minerals are associated with large deviations of observed from calculated total polarizabilities. We have identified several groups of minerals and compounds where deviations from the valence-sum rule at cations lead to polarizability deviations of 2-5%: M(SO4)·nH2O, n = 1-6, blödite-group minerals [Na2M2+(SO4)2·4H2O], and the kieserite-related minerals: isokite, panasqueiraite and tilasite. In these minerals, the environment of the M ions contains both O and H2O: Mg[O4(H2O)2] in kieserite, szmikite, and szomolnokite; Mg[O2(H2O)4] in starkeyite, ilesite, and rozenite, and Mg[(H2O)6] in hexahydrite. In compounds where the ligands are only H2O, deviations from the valence-sum rule at the M(H2O)6 groups are not accompanied by significant polarizability deviations. This is the case for epsomite, MgSO4·7H2O; bieberite, CoSO4·7H2O; goslarite, ZnSO4·7H2O, six silicofluorides, MSiF6·6H2O; eighteen Tutton's salts, M2M'(SO4)2·6H2O, where M = K, Rb, Cs and M' = Mg, Mn, Fe, Co, Ni, Cu, and Zn; and eleven MM'(SO4)2·12H2O alums, where M = Na, K, Rb and Cs, and M' = Al, Cr, Ga and In. This is also the case for the sulfates alunogen, Al2(SO4)3·17H2O and halotrichite, FeAl2(SO4)4·22H2O; three hydrated nitrates; one phosphate; three antimonates and two hydrated perchlorates. A possible explanation for this different behavior is that the bond-valence model treats O and H separately, whereas polarizability calculations treat the polarizability of the entire H2O molecule.

  17. Patient Protection and Affordable Care Act; Market Stabilization. Final rule.

    PubMed

    2017-04-18

    This rule finalizes changes that will help stabilize the individual and small group markets and affirm the traditional role of State regulators. This final rule amends standards relating to special enrollment periods, guaranteed availability, and the timing of the annual open enrollment period in the individual market for the 2018 plan year; standards related to network adequacy and essential community providers for qualified health plans; and the rules around actuarial value requirements.

  18. The Advocate-Witness Rule: Anachronism or Necessary Restraint

    DTIC Science & Technology

    1989-04-01

    Court of Military Appeals ’ aggressive interpretation of the advocate-witness rule and reading of the Model Code provisions concerning the advocate...those federal circuits that formerly all6wed an interlocutory appeal from the denial of a motion to disqualify the opponent’s counsel. See Armstrong...the Supreme Court put an end to such interlocutory appeals in Firestone Tire & Rubber Co. v. Risjord, 449 U.S. 368 (1981)." 409. Note, The Advocate

  19. 27 CFR 70.471 - Rulings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TREASURY (CONTINUED) PROCEDURES AND PRACTICES PROCEDURE AND ADMINISTRATION Procedural Rules Relating to... the Bureau of Alcohol, Tobacco, Firearms and Explosives (Department of Justice), contact the Bureau of...

  20. 27 CFR 70.471 - Rulings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREASURY (CONTINUED) PROCEDURES AND PRACTICES PROCEDURE AND ADMINISTRATION Procedural Rules Relating to... the Bureau of Alcohol, Tobacco, Firearms and Explosives (Department of Justice), contact the Bureau of...

  1. 27 CFR 70.471 - Rulings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREASURY (CONTINUED) PROCEDURES AND PRACTICES PROCEDURE AND ADMINISTRATION Procedural Rules Relating to... the Bureau of Alcohol, Tobacco, Firearms and Explosives (Department of Justice), contact the Bureau of...

  2. 27 CFR 70.471 - Rulings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY (CONTINUED) PROCEDURES AND PRACTICES PROCEDURE AND ADMINISTRATION Procedural Rules Relating to... the Bureau of Alcohol, Tobacco, Firearms and Explosives (Department of Justice), contact the Bureau of...

  3. Ostracod body size trends do not follow either Bergmann's rule or Cope's rule during periods of constant temperature increase

    NASA Astrophysics Data System (ADS)

    Xu, Y.; Seshadri, P.; Amin, V.; Heim, N. A.; Payne, J.

    2013-12-01

    Over time, organisms have adapted to changing environments by evolving to be larger or smaller. Scientists have described body-size trends using two generalized theories. Bergmann's rule states that body size is inversely related to temperature, and Cope's rule establishes an increase over time. Cope's rule has been hypothesized as a temporal manifestation of Bergmann's rule, as the temperature of the Earth has consistently decreased over time and mean body size has increased. However, during times of constant temperature increase, Bergmann's rule and Cope's rule predict opposite effects on body size. Our goal was to clarify this relationship using both accessible proxies of historic temperature - atmospheric CO2 levels and paleo-latitude. We measured ostracod lengths throughout the Paleozoic and Mesozoic eras (using the Catalogue of Ostracoda) and utilized ostracod latitudinal information from the Paleobiology Database. By closely studying body-size trends during four time periods of constant CO2 increase across spectrums of time and latitude, we were able to compare the effects of Cope's and Bergmann's rule. The correlation, p-values, and slopes of each of our graphs showed that there is no clear relationship between body size and each of these rules in times of temperature increase, both latitudinally and temporally. Therefore, both Cope's and Bergmann's rule act on marine ostracods and no rule is dominant, though our results more strongly disprove the latitudinal variation in ostracod size.

  4. 12 CFR Appendix J to Part 226 - Annual Percentage Rate Computations for Closed-End Credit Transactions

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... unpaid balance of the amount financed is increased by the finance charge earned during that period and is... contrast, under the United States Rule method, at the end of each payment period, the unpaid balance of the... earned, the adjustment of the unpaid balance of the amount financed is postponed until the end of the...

  5. Adler Function, Bjorken Sum Rule, and the Crewther Relation to Order {alpha}{sub s}{sup 4} in a General Gauge Theory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baikov, P. A.; Chetyrkin, K. G.; Kuehn, J. H.

    2010-04-02

    We compute, for the first time, the order {alpha}{sub s}{sup 4} contributions to the Bjorken sum rule for polarized electron-nucleon scattering and to the (nonsinglet) Adler function for the case of a generic color gauge group. We confirm at the same order a (generalized) Crewther relation which provides a strong test of the correctness of our previously obtained results: the QCD Adler function and the five-loop {beta} function in quenched QED. In particular, the appearance of an irrational contribution proportional to {zeta}{sub 3} in the latter quantity is confirmed. We obtain the commensurate scale equation relating the effective strong couplingmore » constants as inferred from the Bjorken sum rule and from the Adler function at order {alpha}{sub s}{sup 4}.« less

  6. 31 CFR 408.3 - Rules governing access.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 408.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) SECRET SERVICE... THE SECRET SERVICE AND TEMPORARY OFFICES OF THE PRESIDENT AND STAFF, OR OTHER PERSON PROTECTED BY THE SECRET SERVICE-RULES GOVERNING ACCESS § 408.3 Rules governing access. (a) For the purposes of 18 U.S.C...

  7. 31 CFR 408.3 - Rules governing access.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 408.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) SECRET SERVICE... THE SECRET SERVICE AND TEMPORARY OFFICES OF THE PRESIDENT AND STAFF, OR OTHER PERSON PROTECTED BY THE SECRET SERVICE-RULES GOVERNING ACCESS § 408.3 Rules governing access. (a) For the purposes of 18 U.S.C...

  8. 31 CFR 408.3 - Rules governing access.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 408.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) SECRET SERVICE... THE SECRET SERVICE AND TEMPORARY OFFICES OF THE PRESIDENT AND STAFF, OR OTHER PERSON PROTECTED BY THE SECRET SERVICE-RULES GOVERNING ACCESS § 408.3 Rules governing access. (a) For the purposes of 18 U.S.C...

  9. 31 CFR 408.3 - Rules governing access.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 408.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) SECRET SERVICE... THE SECRET SERVICE AND TEMPORARY OFFICES OF THE PRESIDENT AND STAFF, OR OTHER PERSON PROTECTED BY THE SECRET SERVICE-RULES GOVERNING ACCESS § 408.3 Rules governing access. (a) For the purposes of 18 U.S.C...

  10. 31 CFR 408.3 - Rules governing access.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 408.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) SECRET SERVICE... THE SECRET SERVICE AND TEMPORARY OFFICES OF THE PRESIDENT AND STAFF, OR OTHER PERSON PROTECTED BY THE SECRET SERVICE-RULES GOVERNING ACCESS § 408.3 Rules governing access. (a) For the purposes of 18 U.S.C...

  11. Misconceptions of High School Students Related to the Conceptions of Absolutism and Constitutionalism in History Courses

    ERIC Educational Resources Information Center

    Bal, Mehmet Suat

    2011-01-01

    The goal of this study is to analyze the 10th grade high school students' misconceptions related to the sense of ruling in the Ottoman State during the absolutist and constitutional periods and to investigate the causes of these misconceptions. The data were collected through eight open-ended questions related to the concepts of absolutism and…

  12. Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and related end stage renal disease. A case-control study.

    PubMed

    Stavarachi, Monica; Panduru, N M; Serafinceanu, C; Moţa, E; Moţa, Maria; Cimponeriu, D; Ion, Daniela Adriana

    2011-01-01

    SELL (L-selectin) is a candidate gene for several complex diseases including diabetes mellitus and renal failure. Our aim was to investigate the involvement of P213S SELL gene polymorphism (rs2229569) in type 2 diabetes mellitus (T2DM) and related end stage renal disease (ESRD). Type 2 diabetes mellitus patients without ESRD (n=250) or with ESRD (n=90), ESRD patients without diabetes (n=119) and sex and age matched healthy subjects (n=459) were analyzed in this study. DNA samples from all these subjects were genotyped for the P213S polymorphism by PCR-RFLP technique. Statistical analysis indicated that SELL P213S genotypes and alleles were similar distributed in the patients and control groups (ORSS=0.37, CI 95%: 0.131>0.372>1.06, p=0.05, Yate's correction p=0.09, for T2DM patients without ESRD, ORSS=2.04, CI 95%: 0.365>2.047>1.465, p=0.4, Yate's correction p=0.67, for T2DM patients with ESRD and ORSS=1, CI95%: 0.198>1>5.057, p=1, Yate's correction p=0.67, for non-diabetic with ESRD patients). Also, no significant differences were noticed when we compared the ESRD subjects with diabetes vs. non-diabetic ones (OR=1.798, CI 95%: 0.392>1.798>8.245, p=0.44, Yate's correction p=0.7). No statistically significant results were found in order to sustain the hypothesis of association between SELL gene P213S polymorphism, type 2 diabetes mellitus and end stage renal disease.

  13. Effect of Temporal Relationships in Associative Rule Mining for Web Log Data

    PubMed Central

    Mohd Khairudin, Nazli; Mustapha, Aida

    2014-01-01

    The advent of web-based applications and services has created such diverse and voluminous web log data stored in web servers, proxy servers, client machines, or organizational databases. This paper attempts to investigate the effect of temporal attribute in relational rule mining for web log data. We incorporated the characteristics of time in the rule mining process and analysed the effect of various temporal parameters. The rules generated from temporal relational rule mining are then compared against the rules generated from the classical rule mining approach such as the Apriori and FP-Growth algorithms. The results showed that by incorporating the temporal attribute via time, the number of rules generated is subsequently smaller but is comparable in terms of quality. PMID:24587757

  14. Skin-autofluorescence, a measure of tissue advanced glycation end-products (AGEs), is related to diastolic function in dialysis patients.

    PubMed

    Hartog, Jasper W L; Hummel, Yoran M; Voors, Adriaan A; Schalkwijk, Casper G; Miyata, Toshio; Huisman, Roel M; Smit, Andries J; Van Veldhuisen, Dirk J

    2008-09-01

    Diastolic dysfunction is a frequent cause of heart failure, particularly in dialysis patients. Advanced glycation end-products (AGEs) are increased in dialysis patients and are suggested to play a role in the development of diastolic dysfunction. The aim of our study was to assess whether AGE accumulation in dialysis patients is related to the presence of diastolic dysfunction. Data were analyzed from 43 dialysis patients, age 58 +/- 15 years, of whom 65% were male. Diastolic function was assessed using tissue velocity imaging (TVI) on echocardiography. Tissue AGE accumulation was measured using a validated skin-autofluorescence (skin-AF) reader. Plasma N(epsilon)-(carboxymethyl)lysine (CML) and N(epsilon)-(carboxyethyl)lysine (CEL) were measured by stable-isotope-dilution tandem mass spectrometry. Plasma pentosidine was measured by high-performance liquid chromatography. Skin-AF correlated with mean E' (r = -0.51, P < .001), E/A ratio (r = -0.39, P = .014), and E/E' (r = 0.38, P = .019). Plasma AGEs were not significantly associated with diastolic function. Multivariable linear regression analysis revealed that 54% of the variance of average E' was explained by age (P = .007), dialysis type (P = 0.016), and skin-AF (P = .013). Tissue AGEs measured as skin-AF, but not plasma AGE levels, were related to diastolic function in dialysis patients. Although this may support the concept that tissue AGEs explain part of the increased prevalence of diastolic dysfunction in these patients, the ambiguous relation between plasma and tissue AGEs needs further exploring.

  15. Cyberinfrastructure for End-to-End Environmental Explorations

    NASA Astrophysics Data System (ADS)

    Merwade, V.; Kumar, S.; Song, C.; Zhao, L.; Govindaraju, R.; Niyogi, D.

    2007-12-01

    The design and implementation of a cyberinfrastructure for End-to-End Environmental Exploration (C4E4) is presented. The C4E4 framework addresses the need for an integrated data/computation platform for studying broad environmental impacts by combining heterogeneous data resources with state-of-the-art modeling and visualization tools. With Purdue being a TeraGrid Resource Provider, C4E4 builds on top of the Purdue TeraGrid data management system and Grid resources, and integrates them through a service-oriented workflow system. It allows researchers to construct environmental workflows for data discovery, access, transformation, modeling, and visualization. Using the C4E4 framework, we have implemented an end-to-end SWAT simulation and analysis workflow that connects our TeraGrid data and computation resources. It enables researchers to conduct comprehensive studies on the impact of land management practices in the St. Joseph watershed using data from various sources in hydrologic, atmospheric, agricultural, and other related disciplines.

  16. A co-design process developing heuristics for practitioners providing end of life care for people with dementia.

    PubMed

    Davies, Nathan; Mathew, Rammya; Wilcock, Jane; Manthorpe, Jill; Sampson, Elizabeth L; Lamahewa, Kethakie; Iliffe, Steve

    2016-08-02

    The end of life for someone with dementia can present many challenges for practitioners; such as, providing care if there are swallowing difficulties. This study aimed to develop a toolkit of heuristics (rules-of-thumb) to aid practitioners making end-of-life care decisions for people with dementia. An iterative co-design approach was adopted using a literature review and qualitative methods, including; 1) qualitative interviews and focus groups with family carers and 2) focus groups with health and care professionals. Family carers were recruited from a national charity, purposively sampling those with experience of end-of-life care for a person with dementia. Health and care professionals were purposively sampled to include a broad range of expertise including; general practitioners, palliative care specialists, and geriatricians. A co-design group was established consisting of health and social care experts and family carers, to synthesise the findings from the qualitative work and produce a toolkit of heuristics to be tested in practice. Four broad areas were identified as requiring complex decisions at the end of life; 1) eating/swallowing difficulties, 2) agitation/restlessness, 3) ending life-sustaining treatment, and 4) providing "routine care" at the end of life. Each topic became a heuristic consisting of rules arranged into flowcharts. Eating/swallowing difficulties have three rules; ensuring eating/swallowing difficulties do not come as a surprise, considering if the situation is an emergency, and considering 'comfort feeding' only versus time-trialled artificial feeding. Agitation/restlessness encourages a holistic approach, considering the environment, physical causes, and the carer's wellbeing. Ending life-sustaining treatment supports practitioners through a process of considering the benefits of treatment versus quality-of-life and comfort. Finally, a heuristic on providing routine care such as bathing, prompts practitioners to consider adapting

  17. Display rules for anger and aggression in school-age children.

    PubMed

    Underwood, M K; Coie, J D; Herbsman, C R

    1992-04-01

    2 related studies addressed the development of display rules for anger and the relation between use of display rules for anger and aggressiveness as rated by school peers. Third, fifth, and seventh graders (ages 8.4, 10.9, and 12.8, respectively) gave hypothetical responses to videotaped, anger provoking vignettes. Overall, regardless of how display rules were defined, subjects reported display rules more often with teachers than with peers for both facial expressions and actions. Reported masking of facial expressions of anger increased with age, but only with teachers. Girls reported masking of facial expressions of anger more than boys. There was a trend for aggressive subjects to invoke display rules for anger less than nonaggressive subjects. The phenomenon of display rules for anger is complex and dependent on the way display rules are defined and the age and gender of the subjects. Most of all, whether children say they would behave angrily seems to be determined by the social context for revealing angry feelings; children say they would express anger genuinely much more often with peers than with teachers.

  18. 49 CFR 511.1 - Scope of the rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Scope of the rules. 511.1 Section 511.1 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ADJUDICATIVE PROCEDURES Scope of Rules; Nature of Adjudicative...

  19. Pharmaceutical Industry Off-label Promotion and Self-regulation: A Document Analysis of Off-label Promotion Rulings by the United Kingdom Prescription Medicines Code of Practice Authority 2003-2012.

    PubMed

    Vilhelmsson, Andreas; Davis, Courtney; Mulinari, Shai

    2016-01-01

    European Union law prohibits companies from marketing drugs off-label. In the United Kingdom--as in some other European countries, but unlike the United States--industry self-regulatory bodies are tasked with supervising compliance with marketing rules. The objectives of this study were to (1) characterize off-label promotion rulings in the UK compared to the whistleblower-initiated cases in the US and (2) shed light on the UK self-regulatory mechanism for detecting, deterring, and sanctioning off-label promotion. We conducted structured reviews of rulings by the UK self-regulatory authority, the Prescription Medicines Code of Practice Authority (PMCPA), between 2003 and 2012. There were 74 off-label promotion rulings involving 43 companies and 65 drugs. Nineteen companies were ruled in breach more than once, and ten companies were ruled in breach three or more times over the 10-y period. Drawing on a typology previously developed to analyse US whistleblower complaints, we coded and analysed the apparent strategic goals of each off-label marketing scheme and the practices consistent with those alleged goals. 50% of rulings cited efforts to expand drug use to unapproved indications, and 39% and 38% cited efforts to expand beyond approved disease entities and dosing strategies, respectively. The most frequently described promotional tactic was attempts to influence prescribers (n = 72, 97%), using print material (70/72, 97%), for example, advertisements (21/70, 30%). Although rulings cited prescribers as the prime target of off-label promotion, competing companies lodged the majority of complaints (prescriber: n = 16, 22%, versus companies: n = 42, 57%). Unlike US whistleblower complaints, few UK rulings described practices targeting consumers (n = 3, 4%), payers (n = 2, 3%), or company staff (n = 2, 3%). Eight UK rulings (11%) pertaining to six drugs described promotion of the same drug for the same off-label use as was alleged by whistleblowers in the US. However

  20. 76 FR 24376 - Commission's Ex Parte Rules and Other Procedural Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ...'s Ex Parte Rules and Other Procedural Rules AGENCY: Federal Communications Commission. ACTION: Final rule. SUMMARY: In this document the Commission revises certain ex parte and organizational rules. This document amends and reforms the Commission's rules on ex parte presentations made in the course of...

  1. Mathematical modelling of contact of ruled surfaces: theory and practical application

    NASA Astrophysics Data System (ADS)

    Panchuk, K. L.; Niteyskiy, A. S.

    2016-04-01

    In the theory of ruled surfaces there are well known researches of contact of ruled surfaces along their common generator line (Klein image is often used [1]). In this paper we propose a study of contact of non developable ruled surfaces via the dual vector calculus. The advantages of this method have been demonstrated by E. Study, W. Blaschke and D. N. Zeiliger in differential geometry studies of ruled surfaces in space R3 over the algebra of dual numbers. A practical use of contact is demonstrated by the example modeling of the working surface of the progressive tool for tillage.

  2. Parental Practices and Attitudes Related to Smoke-Free Rules in Homes, Cars, and Outdoor Playgrounds in US Households With Underage Children and Smokers, 2010–2011

    PubMed Central

    Zhang, Xiao; Rhoads, Natalie

    2015-01-01

    Introduction A smoke-free environment protects children from exposure to involuntary smoke and also can reduce or prevent future smoking behavior. The purpose of this study was to examine levels and correlates of parental behavior and attitudes related to voluntary smoke-free rules in homes, cars, and outdoor children’s play areas among US households with underage children and 1 or more smoking parents. Methods We used data from the 2010–2011 Tobacco Use Supplement to the Current Population Survey and logistic regressions to model behavior and attitudes related to voluntary smoke-free rules in 3 settings. Results Overall, 60.1% of households with children and at least 1 smoking parent had voluntary smoke-free home rules. Approximately 84.6% and 71.5% of parents thought that smoking should not be allowed inside cars with children present and in outdoor play areas, respectively. Positive parental behavior and attitudes related to voluntary smoke-free rules were more likely among households with 2 parents, parents of higher education and household income, Hispanic parents, and parents of infants (P < .05). Conclusion Tobacco control and prevention efforts are needed to promote the voluntary adoption of smoke-free rules in homes, private cars, and outdoor children’s play areas. Most parents from smoker households with underage children were supportive of smoke-free laws for cars and outdoor children’s play areas, providing evidence and encouragement to policy makers to take action to restrict smoking in these locations. PMID:26086609

  3. Genetic Information Nondiscrimination Act. Final rule.

    PubMed

    2016-05-17

    The Equal Employment Opportunity Commission (EEOC or Commission) is issuing a final rule to amend the regulations implementing Title II of the Genetic Information Nondiscrimination Act of 2008 as they relate to employer-sponsored wellness programs. This rule addresses the extent to which an employer may offer an inducement to an employee for the employee's spouse to provide information about the spouse's manifestation of disease or disorder as part of a health risk assessment (HRA) administered in connection with an employer-sponsored wellness program. Several technical changes to the existing regulations are included. Published elsewhere in this issue of the Federal Register, the EEOC also issued a final rule to amend the regulations and interpretive guidance implementing Title I of the Americans with Disabilities Act (ADA) that addresses the extent to which employers may use incentives to encourage employees to participate in wellness programs that ask them to respond to disability-related inquiries and/or undergo medical examinations.

  4. Students' Conceptions Supporting Their Symbolization and Meaning of Function Rules

    ERIC Educational Resources Information Center

    Fonger, Nicole L.; Ellis, Amy; Dogan, Muhammed F.

    2016-01-01

    This paper explores the nature of students' quantitative reasoning and conceptions of functions supporting their ability to symbolize quadratic function rules, and the meanings students make of these rules. We analyzed middle school students' problem solving activity during a small group teaching experiment (n = 6) emphasizing quadratic growth…

  5. Why the Three-Point Rule Failed to Sufficiently Reduce the Number of Draws in Soccer: An Application of Prospect Theory.

    PubMed

    Riedl, Dennis; Heuer, Andreas; Strauss, Bernd

    2015-06-01

    Incentives guide human behavior by altering the level of external motivation. We apply the idea of loss aversion from prospect theory (Kahneman & Tversky, 1979) to the point reward systems in soccer and investigate the controversial impact of the three-point rule on reducing the fraction of draws in this sport. Making use of the Poisson nature of goal scoring, we compared empirical results with theoretically deduced draw ratios from 24 countries encompassing 20 seasons each (N = 118.148 matches). The rule change yielded a slight reduction in the ratio of draws, but despite adverse incentives, still 18% more matches ended drawn than expected, t(23) = 11.04, p < .001, d = 2.25, consistent with prospect theory assertions. Alternative point systems that manipulated incentives for losses yielded reductions at or below statistical expectation. This provides support for the deduced concept of how arbitrary aims, such as the reduction of draws in the world's soccer leagues, could be more effectively accomplished than currently attempted.

  6. 49 CFR 1016.101 - Purpose of these rules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Purpose of these rules. 1016.101 Section 1016.101 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION BOARD, DEPARTMENT... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS General Provisions § 1016.101 Purpose of these rules...

  7. 49 CFR 1016.101 - Purpose of these rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Purpose of these rules. 1016.101 Section 1016.101 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION BOARD, DEPARTMENT... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS General Provisions § 1016.101 Purpose of these rules...

  8. 7 CFR 29.1131 - Rule 25.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Rule 25. 29.1131 Section 29.1131 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing....” Crude or green tobacco containing 10 percent or less of oxidized shall be grade “N2.” ...

  9. 7 CFR 29.1131 - Rule 25.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Rule 25. 29.1131 Section 29.1131 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing....” Crude or green tobacco containing 10 percent or less of oxidized shall be grade “N2.” ...

  10. Dynamic Querying of Mass-Storage RDF Data with Rule-Based Entailment Regimes

    NASA Astrophysics Data System (ADS)

    Ianni, Giovambattista; Krennwallner, Thomas; Martello, Alessandra; Polleres, Axel

    RDF Schema (RDFS) as a lightweight ontology language is gaining popularity and, consequently, tools for scalable RDFS inference and querying are needed. SPARQL has become recently a W3C standard for querying RDF data, but it mostly provides means for querying simple RDF graphs only, whereas querying with respect to RDFS or other entailment regimes is left outside the current specification. In this paper, we show that SPARQL faces certain unwanted ramifications when querying ontologies in conjunction with RDF datasets that comprise multiple named graphs, and we provide an extension for SPARQL that remedies these effects. Moreover, since RDFS inference has a close relationship with logic rules, we generalize our approach to select a custom ruleset for specifying inferences to be taken into account in a SPARQL query. We show that our extensions are technically feasible by providing benchmark results for RDFS querying in our prototype system GiaBATA, which uses Datalog coupled with a persistent Relational Database as a back-end for implementing SPARQL with dynamic rule-based inference. By employing different optimization techniques like magic set rewriting our system remains competitive with state-of-the-art RDFS querying systems.

  11. The experience of providing end-of-life care to a relative with advanced dementia: an integrative literature review.

    PubMed

    Peacock, Shelley C

    2013-04-01

    The number of people with dementia is growing at an alarming rate. An abundance of research over the past two decades has examined the complex aspects of caring for a relative with dementia. However, far less research has been conducted specific to the experiences of family caregivers providing end-of-life care, which is perplexing, as dementia is a terminal illness. This article presents what is known and highlights the gaps in the literature relevant to the experiences of family caregivers of persons with dementia at the end of life. A thorough search of the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and PubMed databases from 1960 to 2011 was conducted. Ten studies were identified that specifically addressed the experience of family caregivers providing end-of-life care to a relative with advanced dementia. Common themes of these studies included: 1) the experience of grief, 2) guilt and burden with decision making, 3) how symptoms of depression may or may not be resolved with death of the care receiver, 4) how caregivers respond to the end-stage of dementia, and 5) expressed needs of family caregivers. It is evident from this literature review that much remains to be done to conceptualize the experience of end-of-life caregiving in dementia.

  12. 41 CFR 102-117.100 - What business rules must I consider before acquiring transportation or related services?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What business rules must...) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Business Rules To Consider Before Shipping Freight or Household Goods § 102-117.100 What business rules must I consider before...

  13. 22 CFR 181.5 - Twenty-day rule for concluded agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Twenty-day rule for concluded agreements. 181.5 Section 181.5 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL AGREEMENTS COORDINATION, REPORTING AND PUBLICATION OF INTERNATIONAL AGREEMENTS § 181.5 Twenty-day rule for concluded agreements. (a) Any agency...

  14. 77 FR 18106 - Award Fee for Service and End-Item Contracts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    .... SUMMARY: NASA has adopted, without change, a final rule amending the NASA FAR Supplement (NFS) to update the Award Fee for Service Contracts clause (NFS 1852.216-76) to clarify that the amount of award fee... Award Fee for End-Item Contracts clause (NFS 1852.216-77) to allow the contracting officer to withhold...

  15. 29 CFR 4000.1 - What are these filing rules about?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false What are these filing rules about? 4000.1 Section 4000.1 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION GENERAL FILING, ISSUANCE, COMPUTATION OF TIME, AND RECORD RETENTION Filing Rules § 4000.1 What are these filing rules about...

  16. Dissociation of end systole from end ejection in patients with long-term mitral regurgitation.

    PubMed

    Brickner, M E; Starling, M R

    1990-04-01

    To determine whether left ventricular (LV) end systole and end ejection uncouple in patients with long-term mitral regurgitation, 59 patients (22 control patients with atypical chest pain, 21 patients with aortic regurgitation, and 16 patients with mitral regurgitation) were studied with micromanometer LV catheters and radionuclide angiograms. End systole was defined as the time of occurrence (Tmax) of the maximum time-varying elastance (Emax), and end ejection was defined as the time of occurrence of minimum ventricular volume (minV) and zero systolic flow as approximated by the aortic dicrotic notch (Aodi). The temporal relation between end systole and end ejection in the control patients was Tmax (331 +/- 42 [SD] msec), minV (336 +/- 36 msec), and then, zero systolic flow (355 +/- 23 msec). This temporal relation was maintained in the patients with aortic regurgitation. In contrast, in the patients with mitral regurgitation, the temporal relation was Tmax (266 +/- 49 msec), zero systolic flow (310 +/- 37 msec, p less than 0.01 vs. Tmax), and then, minV (355 +/- 37 msec, p less than 0.001 vs. Tmax and p less than 0.01 vs. Aodi). Additionally, the average Tmax occurred earlier in the patients with mitral regurgitation than in the control patients and patients with aortic regurgitation (p less than 0.01, for both), whereas the average time to minimum ventricular volume was similar in all three patient groups. Moreover, the average time to zero systolic flow also occurred earlier in the patients with mitral regurgitation than in the control patients (p less than 0.01) and patients with aortic regurgitation (p less than 0.05). Because of the dissociation of end systole from minimum ventricular volume in the patients with mitral regurgitation, the end-ejection pressure-volume relations calculated at minimum ventricular volume did not correlate (r = -0.09), whereas those calculated at zero systolic flow did correlate (r = 0.88) with the Emax slope values. We conclude

  17. Pharmaceutical Industry Off-label Promotion and Self-regulation: A Document Analysis of Off-label Promotion Rulings by the United Kingdom Prescription Medicines Code of Practice Authority 2003–2012

    PubMed Central

    Vilhelmsson, Andreas; Davis, Courtney; Mulinari, Shai

    2016-01-01

    Background European Union law prohibits companies from marketing drugs off-label. In the United Kingdom—as in some other European countries, but unlike the United States—industry self-regulatory bodies are tasked with supervising compliance with marketing rules. The objectives of this study were to (1) characterize off-label promotion rulings in the UK compared to the whistleblower-initiated cases in the US and (2) shed light on the UK self-regulatory mechanism for detecting, deterring, and sanctioning off-label promotion. Methods and Findings We conducted structured reviews of rulings by the UK self-regulatory authority, the Prescription Medicines Code of Practice Authority (PMCPA), between 2003 and 2012. There were 74 off-label promotion rulings involving 43 companies and 65 drugs. Nineteen companies were ruled in breach more than once, and ten companies were ruled in breach three or more times over the 10-y period. Drawing on a typology previously developed to analyse US whistleblower complaints, we coded and analysed the apparent strategic goals of each off-label marketing scheme and the practices consistent with those alleged goals. 50% of rulings cited efforts to expand drug use to unapproved indications, and 39% and 38% cited efforts to expand beyond approved disease entities and dosing strategies, respectively. The most frequently described promotional tactic was attempts to influence prescribers (n = 72, 97%), using print material (70/72, 97%), for example, advertisements (21/70, 30%). Although rulings cited prescribers as the prime target of off-label promotion, competing companies lodged the majority of complaints (prescriber: n = 16, 22%, versus companies: n = 42, 57%). Unlike US whistleblower complaints, few UK rulings described practices targeting consumers (n = 3, 4%), payers (n = 2, 3%), or company staff (n = 2, 3%). Eight UK rulings (11%) pertaining to six drugs described promotion of the same drug for the same off-label use as was alleged by

  18. Advanced glycation end-products: a review.

    PubMed

    Singh, R; Barden, A; Mori, T; Beilin, L

    2001-02-01

    Advanced glycation end-products are a complex and heterogeneous group of compounds that have been implicated in diabetes related complications. At present it is not known if they are the cause or the consequence of the complications observed. We discuss the chemistry of advanced glycated end-product formation and their patho-biochemistry particularly in relation to the diabetic microvascular complications of retinopathy, neuropathy and nephropathy as well as their role in the accelerated vasculopathy observed in diabetes. The concept of carbonyl stress as a cause for advanced glycated end-product toxicity is mentioned. We discuss alterations in the concentrations of advanced glycated end-products in the body, particularly in relation to changes occurring with age, diabetes and its complications such as nephropathy. Problems relating to current methods of advanced glycated end-product detection and measurement are highlighted including the lack of a universally established method of detection or unit of measurement. Agents used for the treatment of advanced glycated end-product accumulation are reviewed, with an emphasis on the results of the recent phase III trials using aminoguanidine and diabetes related complications.

  19. Australian road rules

    DOT National Transportation Integrated Search

    2009-02-01

    *These are national-level rules. Australian Road Rules - 2009 Version, Part 18, Division 1, Rule 300 "Use of Mobile Phones" describes restrictions of mobile phone use while driving. The rule basically states that drivers cannot make or receive calls ...

  20. Rules and Self-Rules: Effects of Variation upon Behavioral Sensitivity to Change

    ERIC Educational Resources Information Center

    Baumann, Ana A.; Abreu-Rodrigues, Josele; da Silva Souza, Alessandra

    2009-01-01

    Four experiments compared the effects of self-rules and rules, and varied and specific schedules of reinforcement. Participants were first exposed to either several schedules (varied groups) or to one schedule (specific groups) and either were asked to generate rules (self-rule groups), were provided rules (rule groups), or were not asked nor…

  1. Music models aberrant rule decoding and reward valuation in dementia

    PubMed Central

    Clark, Camilla N; Golden, Hannah L; McCallion, Oliver; Nicholas, Jennifer M; Cohen, Miriam H; Slattery, Catherine F; Paterson, Ross W; Fletcher, Phillip D; Mummery, Catherine J; Rohrer, Jonathan D; Crutch, Sebastian J; Warren, Jason D

    2018-01-01

    Abstract Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these processes remain poorly characterized. Here we used music to probe rule decoding and reward valuation in patients with frontotemporal dementia (FTD) syndromes and Alzheimer’s disease (AD) relative to healthy age-matched individuals. We created short melodies that were either harmonically resolved (‘finished’) or unresolved (‘unfinished’); the task was to classify each melody as finished or unfinished (rule processing) and rate its subjective pleasantness (reward valuation). Results were adjusted for elementary pitch and executive processing; neuroanatomical correlates were assessed using voxel-based morphometry. Relative to healthy older controls, patients with behavioural variant FTD showed impairments of both musical rule decoding and reward valuation, while patients with semantic dementia showed impaired reward valuation but intact rule decoding, patients with AD showed impaired rule decoding but intact reward valuation and patients with progressive non-fluent aphasia performed comparably to healthy controls. Grey matter associations with task performance were identified in anterior temporal, medial and lateral orbitofrontal cortices, previously implicated in computing diverse biological and non-biological rules and rewards. The processing of musical rules and reward distils cognitive and neuroanatomical mechanisms relevant to complex socio-emotional dysfunction in major dementias. PMID:29186630

  2. Hot electron energy relaxation in lattice-matched InAlN/AlN/GaN heterostructures: The sum rules for electron-phonon interactions and hot-phonon effect

    NASA Astrophysics Data System (ADS)

    Zhang, J.-Z.; Dyson, A.; Ridley, B. K.

    2015-01-01

    Using the dielectric continuum (DC) and three-dimensional phonon (3DP) models, energy relaxation (ER) of the hot electrons in the quasi-two-dimensional channel of lattice-matched InAlN/AlN/GaN heterostructures is studied theoretically, taking into account non-equilibrium polar optical phonons, electron degeneracy, and screening from the mobile electrons. The electron power dissipation (PD) and ER time due to both half-space and interface phonons are calculated as functions of the electron temperature Te using a variety of phonon lifetime values from experiment, and then compared with those evaluated by the 3DP model. Thereby, particular attention is paid to examination of the 3DP model to use for the hot-electron relaxation study. The 3DP model yields very close results to the DC model: With no hot phonons or screening, the power loss calculated from the 3DP model is 5% smaller than the DC power dissipation, whereas slightly larger 3DP power loss (by less than 4% with a phonon lifetime from 0.1 to 1 ps) is obtained throughout the electron temperature range from room temperature to 2500 K after including both the hot-phonon effect (HPE) and screening. Very close results are obtained also for ER time with the two phonon models (within a 5% of deviation). However, the 3DP model is found to underestimate the HPE by 9%. The Mori-Ando sum rule is restored by which it is proved that the PD values obtained from the DC and 3DP models are in general different in the spontaneous phonon emission process, except when scattering with interface phonons is sufficiently weak, or when the degenerate modes condition is imposed, which is also consistent with Register's scattering rate sum rule. The discrepancy between the DC and 3DP results is found to be caused by how much the high-energy interface phonons contribute to the ER: their contribution is enhanced in the spontaneous emission process but is dramatically reduced after including the HPE. Our calculation with both phonon

  3. A geometric constraint, the head-to-tail exclusion rule, may be the basis for the isolated-pentagon rule in fullerenes with more than 60 vertices

    PubMed Central

    Schein, Stan; Friedrich, Tara

    2008-01-01

    Carbon atoms self-assemble into the famous soccer-ball shaped Buckminsterfullerene (C60), the smallest fullerene cage that obeys the isolated-pentagon rule (IPR). Carbon atoms self-assemble into larger (n > 60 vertices) empty cages as well—but only the few that obey the IPR—and at least 1 small fullerene (n ≤ 60) with adjacent pentagons. Clathrin protein also self-assembles into small fullerene cages with adjacent pentagons, but just a few of those. We asked why carbon atoms and clathrin proteins self-assembled into just those IPR and small cage isomers. In answer, we described a geometric constraint—the head-to-tail exclusion rule—that permits self-assembly of just the following fullerene cages: among the 5,769 possible small cages (n ≤ 60 vertices) with adjacent pentagons, only 15; the soccer ball (n = 60); and among the 216,739 large cages with 60 < n ≤ 84 vertices, only the 50 IPR ones. The last finding was a complete surprise. Here, by showing that the largest permitted fullerene with adjacent pentagons is one with 60 vertices and a ring of interleaved hexagons and pentagon pairs, we prove that for all n > 60, the head-to-tail exclusion rule permits only (and all) fullerene cages and nanotubes that obey the IPR. We therefore suggest that self-assembly that obeys the IPR may be explained by the head-to-tail exclusion rule, a geometric constraint. PMID:19050075

  4. The development of display rule knowledge: linkages with family expressiveness and social competence.

    PubMed

    Jones, D C; Abbey, B B; Cumberland, A

    1998-08-01

    The development of display rule knowledge and its associations with family expressiveness (Study 1) and peer competence (Study 2) were investigated among elementary school children. In Study 1, the display rule knowledge of 121 kindergartners and third graders was assessed using validated hypothetical scenarios. There were significant grade differences in display rule knowledge such that third graders compared to kindergartners more frequently combined expression regulation with prosocial reasoning, norm-maintenance, and self-protective motives. Maternal reports of family emotional climates indicated that aspects of negative expressiveness were related positively to self-protective display rules and negatively to prosocial display rules. Study 2 included 93 third and fifth graders who reported on their display rule knowledge and on their emotional reactions and strategies to resolve peer conflict. Classmates and teachers provided ratings on social competence. Age differences for display rule knowledge were not documented, but prosocial display rules were most consistently related to hypothetical peer conflict responses and social competence. The findings confirm that display rule knowledge is related in consistent and systematic ways to what children learn within the family emotional context, how they propose to resolve peer conflict, and how they are perceived by peers and teachers.

  5. 41 CFR 60-1.44 - Rulings and interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Rulings and interpretations. 60-1.44 Section 60-1.44 Public Contracts and Property Management Other Provisions Relating to... OF LABOR 1-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS Ancillary Matters § 60-1.44 Rulings and...

  6. 41 CFR 60-1.44 - Rulings and interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Rulings and interpretations. 60-1.44 Section 60-1.44 Public Contracts and Property Management Other Provisions Relating to... OF LABOR 1-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS Ancillary Matters § 60-1.44 Rulings and...

  7. The 1% Rule in Four Digital Health Social Networks: An Observational Study

    PubMed Central

    2014-01-01

    Background In recent years, cyberculture has informally reported a phenomenon named the 1% rule, or 90-9-1 principle, which seeks to explain participatory patterns and network effects within Internet communities. The rule states that 90% of actors observe and do not participate, 9% contribute sparingly, and 1% of actors create the vast majority of new content. This 90%, 9%, and 1% are also known as Lurkers, Contributors, and Superusers, respectively. To date, very little empirical research has been conducted to verify the 1% rule. Objective The 1% rule is widely accepted in digital marketing. Our goal was to determine if the 1% rule applies to moderated Digital Health Social Networks (DHSNs) designed to facilitate behavior change. Methods To help gain insight into participatory patterns, descriptive data were extracted from four long-standing DHSNs: the AlcoholHelpCenter, DepressionCenter, PanicCenter, and StopSmokingCenter sites. Results During the study period, 63,990 actors created 578,349 posts. Less than 25% of actors made one or more posts. The applicability of the 1% rule was confirmed as Lurkers, Contributors, and Superusers accounted for a weighted average of 1.3% (n=4668), 24.0% (n=88,732), and 74.7% (n=276,034) of content. Conclusions The 1% rule was consistent across the four DHSNs. As social network sustainability requires fresh content and timely interactions, these results are important for organizations actively promoting and managing Internet communities. Superusers generate the vast majority of traffic and create value, so their recruitment and retention is imperative for long-term success. Although Lurkers may benefit from observing interactions between Superusers and Contributors, they generate limited or no network value. The results of this study indicate that DHSNs may be optimized to produce network effects, positive externalities, and bandwagon effects. Further research in the development and expansion of DHSNs is required. PMID:24496109

  8. The 1% rule in four digital health social networks: an observational study.

    PubMed

    van Mierlo, Trevor

    2014-02-04

    In recent years, cyberculture has informally reported a phenomenon named the 1% rule, or 90-9-1 principle, which seeks to explain participatory patterns and network effects within Internet communities. The rule states that 90% of actors observe and do not participate, 9% contribute sparingly, and 1% of actors create the vast majority of new content. This 90%, 9%, and 1% are also known as Lurkers, Contributors, and Superusers, respectively. To date, very little empirical research has been conducted to verify the 1% rule. The 1% rule is widely accepted in digital marketing. Our goal was to determine if the 1% rule applies to moderated Digital Health Social Networks (DHSNs) designed to facilitate behavior change. To help gain insight into participatory patterns, descriptive data were extracted from four long-standing DHSNs: the AlcoholHelpCenter, DepressionCenter, PanicCenter, and StopSmokingCenter sites. During the study period, 63,990 actors created 578,349 posts. Less than 25% of actors made one or more posts. The applicability of the 1% rule was confirmed as Lurkers, Contributors, and Superusers accounted for a weighted average of 1.3% (n=4668), 24.0% (n=88,732), and 74.7% (n=276,034) of content. The 1% rule was consistent across the four DHSNs. As social network sustainability requires fresh content and timely interactions, these results are important for organizations actively promoting and managing Internet communities. Superusers generate the vast majority of traffic and create value, so their recruitment and retention is imperative for long-term success. Although Lurkers may benefit from observing interactions between Superusers and Contributors, they generate limited or no network value. The results of this study indicate that DHSNs may be optimized to produce network effects, positive externalities, and bandwagon effects. Further research in the development and expansion of DHSNs is required.

  9. 26 CFR 1.871-14 - Rules relating to repeal of tax on interest of nonresident alien individuals and foreign...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Application of 10-percent shareholder test to interest paid to a simple trust or grantor trust. Whether interest paid to a simple trust or grantor trust and distributed to or included in the gross income of a... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Rules relating to repeal of tax on interest of...

  10. The island rule: made to be broken?

    PubMed Central

    Meiri, Shai; Cooper, Natalie; Purvis, Andy

    2007-01-01

    The island rule is a hypothesis whereby small mammals evolve larger size on islands while large insular mammals dwarf. The rule is believed to emanate from small mammals growing larger to control more resources and enhance metabolic efficiency, while large mammals evolve smaller size to reduce resource requirements and increase reproductive output. We show that there is no evidence for the existence of the island rule when phylogenetic comparative methods are applied to a large, high-quality dataset. Rather, there are just a few clade-specific patterns: carnivores; heteromyid rodents; and artiodactyls typically evolve smaller size on islands whereas murid rodents usually grow larger. The island rule is probably an artefact of comparing distantly related groups showing clade-specific responses to insularity. Instead of a rule, size evolution on islands is likely to be governed by the biotic and abiotic characteristics of different islands, the biology of the species in question and contingency. PMID:17986433

  11. Optimal Hedging Rule for Reservoir Refill Operation

    NASA Astrophysics Data System (ADS)

    Wan, W.; Zhao, J.; Lund, J. R.; Zhao, T.; Lei, X.; Wang, H.

    2015-12-01

    This paper develops an optimal reservoir Refill Hedging Rule (RHR) for combined water supply and flood operation using mathematical analysis. A two-stage model is developed to formulate the trade-off between operations for conservation benefit and flood damage in the reservoir refill season. Based on the probability distribution of the maximum refill water availability at the end of the second stage, three zones are characterized according to the relationship among storage capacity, expected storage buffer (ESB), and maximum safety excess discharge (MSED). The Karush-Kuhn-Tucker conditions of the model show that the optimality of the refill operation involves making the expected marginal loss of conservation benefit from unfilling (i.e., ending storage of refill period less than storage capacity) as nearly equal to the expected marginal flood damage from levee overtopping downstream as possible while maintaining all constraints. This principle follows and combines the hedging rules for water supply and flood management. A RHR curve is drawn analogously to water supply hedging and flood hedging rules, showing the trade-off between the two objectives. The release decision result has a linear relationship with the current water availability, implying the linearity of RHR for a wide range of water conservation functions (linear, concave, or convex). A demonstration case shows the impacts of factors. Larger downstream flood conveyance capacity and empty reservoir capacity allow a smaller current release and more water can be conserved. Economic indicators of conservation benefit and flood damage compete with each other on release, the greater economic importance of flood damage is, the more water should be released in the current stage, and vice versa. Below a critical value, improving forecasts yields less water release, but an opposing effect occurs beyond this critical value. Finally, the Danjiangkou Reservoir case study shows that the RHR together with a rolling

  12. 17 CFR 240.3a40-1 - Designation of financial responsibility rules.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... relating to hypothecation or lending of customer securities; (c) Any rule adopted by any self-regulatory... other rule adopted by the Commission or any self-regulatory organization relating to the protection of...

  13. A Study of Hospital Admission Rules During Pediatric Residency Training.

    ERIC Educational Resources Information Center

    Ferguson, Jane; Alpert, Joel J.

    1980-01-01

    A survey of U.S. pediatric training programs to determine the role of rules in the hospital admission of pediatric patients is reported. The results support the hypothesis that rules are a widely used teaching tool. The rules relate to such factors as fevers, age, specific diseases, administrative concerns, head traumas, and poisonings. (JMD)

  14. 45 CFR 149.340 - Rule for insured plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Rule for insured plans. 149.340 Section 149.340 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Reimbursement Methods § 149.340 Rule for insured plans...

  15. 45 CFR 149.340 - Rule for insured plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Rule for insured plans. 149.340 Section 149.340 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Reimbursement Methods § 149.340 Rule for insured plans...

  16. 45 CFR 304.11 - Effect of State rules.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Effect of State rules. 304.11 Section 304.11 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT... FEDERAL FINANCIAL PARTICIPATION § 304.11 Effect of State rules. Subject to the provisions and limitations...

  17. 45 CFR 304.11 - Effect of State rules.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Effect of State rules. 304.11 Section 304.11 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT... FEDERAL FINANCIAL PARTICIPATION § 304.11 Effect of State rules. Subject to the provisions and limitations...

  18. 31 CFR 356.32 - What tax rules apply?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false What tax rules apply? 356.32 Section 356.32 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL...) Miscellaneous Provisions § 356.32 What tax rules apply? (a) General. Securities issued under this part are...

  19. 31 CFR 356.32 - What tax rules apply?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What tax rules apply? 356.32 Section 356.32 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL...) Miscellaneous Provisions § 356.32 What tax rules apply? (a) General. Securities issued under this part are...

  20. 31 CFR 356.32 - What tax rules apply?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false What tax rules apply? 356.32 Section 356.32 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL...) Miscellaneous Provisions § 356.32 What tax rules apply? (a) General. Securities issued under this part are...

  1. Results of end-to-end cavocavostomy during adult liver transplantation.

    PubMed

    Glanemann, Matthias; Settmacher, Utz; Langrehr, Jan M; Stange, Barbara; Haase, Roland; Nuessler, Natascha C; Lopez-Hänninen, Enrique; Podrabsky, Petr; Bechstein, Wolf-Otto; Neuhaus, Peter

    2002-03-01

    The results of end-to-end cavocavostomy during adult liver transplantation were analyzed with special regard to caval complications. In a series of 1000 liver transplants, we observed 17 patients who suffered from postoperative caval obstruction (6 patients) or caval stenosis (11 patients), for an incidence of 1.7%. Surgical therapy was performed in 10 patients (58.8%), and 5 patients required retransplantation (29.4%). Four patients died during the later postoperative course. Two fatalities were related to caval complications, resulting in a mortality rate of 11.8%. Our results indicate that end-to-end cavocavostomy is a safe technique for cavocaval anastomosis. For only a few exceptions, such as pediatric transplantation, reduced size livers, or size mismatch between donor and recipient, should alternative techniques such as end-to-side or side-to-side cavocavostomy be performed.

  2. Boxing fatalities in relation to rule changes in Japan: secondary data analysis.

    PubMed

    Teramoto, Masaru; Cross, Chad L; Cushman, Daniel M; Willick, Stuart E

    2018-01-18

    To examine whether changing weigh-in from the same day of the match to the day before the match and prohibiting 6-oz gloves are associated with fatalities in boxing matches sanctioned by the Japan Boxing Commission (JBC). We analyzed the rates of boxing fatalities before and after the two rule changes above via secondary analysis of data. Demographics and boxing records of deceased boxers were examined using descriptive statistics, exact binomial test the Mann-Whitney-Wilcoxon test and Fisher's exact tests. As of this study, a total of 38 boxers (23.9 ± 3.3 years of age) reportedly died due to injuries sustained in JBC-sanctioned boxing matches since 1952. Changing weigh-in to the day before the match or prohibiting 6-oz gloves was not significantly associated with the rates of boxing fatalities 5 years and 10 years before and after the rule changes (p > 0.05). Deceased boxers after these rule changes were significantly older, completed significantly more rounds in the final match, and were significantly less likely to lose the previous match (prior to the final match) and to do so by knockouts (p < 0.05). Changing weigh-in to the day before the match and prohibiting 6-oz gloves may not result in reducing boxing fatalities.

  3. Accurate Predictions of Mean Geomagnetic Dipole Excursion and Reversal Frequencies, Mean Paleomagnetic Field Intensity, and the Radius of Earth's Core Using McLeod's Rule

    NASA Technical Reports Server (NTRS)

    Voorhies, Coerte V.; Conrad, Joy

    1996-01-01

    The geomagnetic spatial power spectrum R(sub n)(r) is the mean square magnetic induction represented by degree n spherical harmonic coefficients of the internal scalar potential averaged over the geocentric sphere of radius r. McLeod's Rule for the magnetic field generated by Earth's core geodynamo says that the expected core surface power spectrum (R(sub nc)(c)) is inversely proportional to (2n + 1) for 1 less than n less than or equal to N(sub E). McLeod's Rule is verified by locating Earth's core with main field models of Magsat data; the estimated core radius of 3485 kn is close to the seismologic value for c of 3480 km. McLeod's Rule and similar forms are then calibrated with the model values of R(sub n) for 3 less than or = n less than or = 12. Extrapolation to the degree 1 dipole predicts the expectation value of Earth's dipole moment to be about 5.89 x 10(exp 22) Am(exp 2)rms (74.5% of the 1980 value) and the expected geomagnetic intensity to be about 35.6 (mu)T rms at Earth's surface. Archeo- and paleomagnetic field intensity data show these and related predictions to be reasonably accurate. The probability distribution chi(exp 2) with 2n+1 degrees of freedom is assigned to (2n + 1)R(sub nc)/(R(sub nc). Extending this to the dipole implies that an exceptionally weak absolute dipole moment (less than or = 20% of the 1980 value) will exist during 2.5% of geologic time. The mean duration for such major geomagnetic dipole power excursions, one quarter of which feature durable axial dipole reversal, is estimated from the modern dipole power time-scale and the statistical model of excursions. The resulting mean excursion duration of 2767 years forces us to predict an average of 9.04 excursions per million years, 2.26 axial dipole reversals per million years, and a mean reversal duration of 5533 years. Paleomagnetic data show these predictions to be quite accurate. McLeod's Rule led to accurate predictions of Earth's core radius, mean paleomagnetic field

  4. The significance of end-of-life dreams and visions.

    PubMed

    Grant, Pei; Wright, Scott; Depner, Rachel; Luczkiewicz, Debra

    End-of-life dreams and visions (ELDVs) have been well documented through history and across cultures. They appear to affect both dying people and their families deeply, and may be a source of profound meaning and comfort. The aims of the study were to; document hospice patients' ELDV experiences over time using a daily survey, examine the content and subjective significance of ELDVs, and relate the prevalence, content and significance of end-of-life experiences over time until death. Patients (n = 66) in a hospice inpatient unit, between January 2011 and July 2012, were interviewed daily. The interview contained closed questions about the content, frequency and level of comfort or distress of dreams and visions. Most participants reported at least one dream or vision and almost half of the dreams and visions occurred during sleep. Nearly all patients reported that their experience felt real. The most common content featured deceased friends and relatives, followed by living friends and relatives. As participants approached death, comforting dreams and visions of the deceased became more prevalent. End-of-life dreams and visions are commonly experienced during dying. These dreams and visions may be a profound source of potential meaning and comfort to the dying.

  5. 77 FR 46561 - Amendments to Adjudicatory Process Rules and Related Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... eight late-filed factors, especially not for late-filed hearing requests or intervention petitions. The... current three Sec. 2.309(f)(2) factors. As the NRC explained in the proposed rule, whether filings after... the existence of good cause, not the other factors. The commenter has not supported its assertion that...

  6. Inference in fuzzy rule bases with conflicting evidence

    NASA Technical Reports Server (NTRS)

    Koczy, Laszlo T.

    1992-01-01

    Inference based on fuzzy 'If ... then' rules has played a very important role since when Zadeh proposed the Compositional Rule of Inference and, especially, since the first successful application presented by Mamdani. From the mid-1980's when the 'fuzzy boom' started in Japan, numerous industrial applications appeared, all using simplified techniques because of the high levels of computational complexity. Another feature is that antecedents in the rules are distributed densely in the input space, so the conclusion can be calculated by some weighted combination of the consequents of the matching (fired) rules. The CRI works in the following way: If R is a rule and A* is an observation, the conclusion is computed by B* = R o A* (o stands for the max-min composition). Algorithms implementing this idea directly have an exponential time complexity (maybe the problem is NP-hard) as the rules are relations in X x Y, a k1 x k2 dimensional space, if X is k1, Y is k2 dimensional. The simplified techniques usually decompose the relation into k1 projections in X(sub i) and measure in some way the degree of similarity between observation and antecedent by some parameter of the overlapping. These parameters are aggregated to a single value in (0,1) which is applied as a resulting weight for the given rule. The projections of rules in dimensions Y(sub i) are weighted by these aggregated values and then they are combined in order to obtain a resulting conclusion separately in every dimension. This method is unapplicable with sparse bases as there is no guarantee that an arbitrary observation matches with any of the antecedents. Then, the degree of similarity is 0 and all consequents are weighted by 0. Some considerations for such a situation are summarized in the next sections.

  7. Evaluation of End Mill Coatings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    L. J. Lazarus; R. L. Hester,

    2005-08-01

    Milling tests were run on families of High Speed Steel (HSS) end mills to determine their lives while machining 304 Stainless Steel. The end mills tested were made from M7, M42 and T15-CPM High Speed Steels. The end mills were also evaluated with no coatings as well as with Titanium Nitride (TiN) and Titanium Carbo-Nitride (TiCN) coatings to determine which combination of HSS and coating provided the highest increase in end mill life while increasing the cost of the tool the least. We found end mill made from M42 gave us the largest increase in tool life with the leastmore » increase in cost. The results of this study will be used by Cutting Tool Engineering in determining which end mill descriptions will be dropped from our tool catalog.« less

  8. Phosphorus-31, sup 15 N, and sup 13 C NMR of glyphosate: Comparison of pH titrations to the herbicidal dead-end complex with 5-enolpyruvoylshikimate-3-phosphate synthase

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Castellino, S.; Leo, G.C.; Sammons, R.D.

    1989-05-02

    The herbicidal dead-end ternary complex (E{sup S3P}{sub Glyph}) of glyphosate (N-(phosphonomethyl)glycine) with 5-enolpyruvoylshikimate-3-phosphate synthase (EPSPS) and the substrate shikimate 3-phosphate (S3P) has been characterized by {sup 31}P, {sup 15}N, and {sup 13}C NMR. The NMR spectra of EPSPS-bound glyphosate show unique chemical shifts ({delta}) for each of the three nuclei. By {sup 31}P NMR, glyphosate in the dead-end complex is a distinct species 3.5 ppm downfield from free glyphosate. The {sup 13}C signal of glyphosate in the dead-end complex is shifted 4 ppm downfield from that of free glyphosate. The {sup 15}N signal for glyphosate (99%) in the dead-end complexmore » is 5 ppm further downfield than that of any free zwitterionic species and 10 ppm downfield from that of the average free species at pH 10.1. The structures of each ionic state of glyphosate are modeled with force field calculations by using MacroModel. A correlation is made for the {sup 31}P {delta} and the C-P-O bond angle, and the {sup 13}C and {sup 15}N {delta} values are postulated to be related to C-C-O and C-N-C bond angles, respectively. The downfield {sup 31}P chemical shift perturbation for S3P in the EPSPS binary complex is consistent with ionization of the 3-phosphate of S3P upon binding. Comparison with the S3P {sup 31}P {delta} vs pH titration curve specifies predominantly the dianion of the 3-phosphate in the E{sup S3P} binary complex, while the E{sup S3P}{sub Glyph} complex indicates net protonation at the 3-phosphate. Chemical shift perturbations of this latter type may be explained by changes in the O-P-O bond angle.« less

  9. Florida Court: Vouchers Unconstitutional--Ruling Will End Opportunity Scholarships Program for Students in State's Lowest-Rated Schools

    ERIC Educational Resources Information Center

    Richard, Alan

    2006-01-01

    Florida's voucher program for students in the lowest-rated public schools is unconstitutional, the state supreme court ruled early January 2006 in a 5-2 decision that friends and foes of private school choice are scrutinizing for its potential impact on voucher debates nationwide. Chief Justice Barbara J. Pariente of the Florida Supreme Court…

  10. 26 CFR 1.451-1 - General rule for taxable year of inclusion.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false General rule for taxable year of inclusion. 1... General rule for taxable year of inclusion. (a) General rule. Gains, profits, and income are to be... received during such year shall be included. (For rules relating to the inclusion of partnership income in...

  11. 76 FR 52371 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... PHLX LLC Relating to Clarifying Amendments to the Rule Book August 16, 2011. Pursuant to Section 19(b... text. The Exchange also proposes to eliminate an unnecessary title in the Rule Book. The text of the... Rule Book. The various amendments relate to cross-references and text in several Rules that were not...

  12. Forest Practice Rules and cumulative watershed impacts in California

    Treesearch

    L. M. Reid

    1999-01-01

    Response to the following questions, "As currently implemented, are existing California forest practice rules effective in preventing cumulative watershed impacts, including flooding?" and "What kind of measures might improve the effectiveness of forest practices rules for avoiding forestry-related cumulative watershed impacts

  13. 26 CFR 1.1275-2 - Special rules relating to debt instruments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... an arrangement that is designed to avoid the aggregation rule (e.g., debt instruments issued by or to... instruments issued separately to other purchasers. On January 1, 1995, Corporation M issues two series of bonds, Series A and Series B. The two series are sold for cash and have different terms. Although some...

  14. 45 CFR 146.145 - Special rules relating to group health plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH INSURANCE MARKET Preemption and Special Rules § 146... group health insurance coverage) for any plan year, if on the first day of the plan year, the plan has...— (A) Medicare supplemental health insurance (as defined under section 1882(g)(1) of the Social...

  15. Efficient photocatalytic degradation of gaseous N,N-dimethylformamide in tannery waste gas using doubly open-ended Ag/TiO2 nanotube array membranes

    NASA Astrophysics Data System (ADS)

    Zhao, Yang; Ma, Lin; Chang, Wenkai; Huang, Zhiding; Feng, Xugen; Qi, Xiaoxia; Li, Zenghe

    2018-06-01

    Gaseous N,N-dimethylformamide (DMF), typical volatile organic compound exhausted from manufacturing factories, may damage the health of workers under long-term exposure even at low levels. The defined geometry, porous surface and highly ordered channels make the free-standing anodic TiO2 nanotube (TiNT) arrays particularly suitable for applications of practical air purification by flow-through photocatalysis. In the present work, crystallized doubly open-ended Ag/TiNT array membranes were designed and prepared by employing a lift-off process based on an anodization-annealing-anodization-etching sequence, followed by uniform Ag nanoparticles decoration. For the photocatalytic degradation of gaseous DMF at low concentration levels close to that found in realistic pollutant air, an analytical methodology for the monitoring and determination of degradation process was developed based on the coupling of headspace sampling with gas chromatography mass spectrometry (HS-GC-MS). The doubly open-ended Ag/TiNT arrays exhibited higher removal efficiency of gaseous DMF from air compared with conventional bottom-closed Ag/TiNT arrays and pure bottomless TiNT arrays. These results indicated that the photocatalytic properties of TiNT arrays were improved with the open-bottom morphology and the Ag nanoparticles decoration. Based on the analysis with GC-MS and high performance ion chromatography (HPIC), it was found that demethylation is the main pathway of DMF degradation in photocatalytic reactions. Furthermore, decontamination of actual polluted tannery waste gas collected in leather factory proved that the photocatalysis on doubly open-ended Ag/TiNT array membrane is an efficient way and a promising application to treat air contaminated by DMF despite the complexity of various volatile organic compounds.

  16. 26 CFR 1.451-1 - General rule for taxable year of inclusion.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 6 2013-04-01 2013-04-01 false General rule for taxable year of inclusion. 1....451-1 General rule for taxable year of inclusion. (a) General rule. Gains, profits, and income are to... received during such year shall be included. (For rules relating to the inclusion of partnership income in...

  17. 26 CFR 1.451-1 - General rule for taxable year of inclusion.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 6 2012-04-01 2012-04-01 false General rule for taxable year of inclusion. 1....451-1 General rule for taxable year of inclusion. (a) General rule. Gains, profits, and income are to... received during such year shall be included. (For rules relating to the inclusion of partnership income in...

  18. 26 CFR 1.451-1 - General rule for taxable year of inclusion.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 6 2014-04-01 2014-04-01 false General rule for taxable year of inclusion. 1....451-1 General rule for taxable year of inclusion. (a) General rule. Gains, profits, and income are to... received during such year shall be included. (For rules relating to the inclusion of partnership income in...

  19. 26 CFR 1.451-1 - General rule for taxable year of inclusion.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false General rule for taxable year of inclusion. 1....451-1 General rule for taxable year of inclusion. (a) General rule. Gains, profits, and income are to... received during such year shall be included. (For rules relating to the inclusion of partnership income in...

  20. Grey matter volume in the cerebellum is related to the processing of grammatical rules in a second language: a structural voxel-based morphometry study.

    PubMed

    Pliatsikas, Christos; Johnstone, Tom; Marinis, Theodoros

    2014-02-01

    The experience of learning and using a second language (L2) has been shown to affect the grey matter (GM) structure of the brain. Importantly, GM density in several cortical and subcortical areas has been shown to be related to performance in L2 tasks. Here, we show that bilingualism can lead to increased GM volume in the cerebellum, a structure that has been related to the processing of grammatical rules. Additionally, the cerebellar GM volume of highly proficient L2 speakers is correlated to their performance in a task tapping on grammatical processing in an L2, demonstrating the importance of the cerebellum for the establishment and use of grammatical rules in an L2.

  1. Double 90 Degrees Counterrotated End-to-End-Anastomosis: An Experimental Study of an Intestinal Anastomosis Technique.

    PubMed

    Holzner, Philipp; Kulemann, Birte; Seifert, Gabriel; Glatz, Torben; Chikhladze, Sophia; Höppner, Jens; Hopt, Ulrich; Timme, Sylvia; Bronsert, Peter; Sick, Olivia; Zhou, Cheng; Marjanovic, Goran

    2015-06-01

    The aim of the article is to investigate a new anastomotic technique compared with standardized intestinal anastomotic procedures. A total of 32 male Wistar rats were randomized to three groups. In the Experimental Group (n = 10), the new double 90 degrees inversely rotated anastomosis was used, in the End Group (n = 10) a single-layer end-to-end anastomosis, and in the Side Group (n = 12) a single-layer side-to-side anastomosis. All anastomoses were done using interrupted sutures. On postoperative day 4, rats were relaparotomized. Bursting pressure, hydroxyproline concentration, a semiquantitative adhesion score and two histological anastomotic healing scores (mucosal healing according to Chiu and overall anastomotic healing according to Verhofstad) were collected. Most data are presented as median (range). p < 0.05 was considered significant. Anastomotic insufficiency occurred only in one rat of the Side Group. Median bursting pressure in the Experimental Group was 105 mm Hg (range = 72-161 mm Hg), significantly higher in the End Group (164 mm Hg; range = 99-210 mm Hg; p = 0.021) and lower in the Side Group by trend (81 mm Hg; range = 59-122 mm Hg; p = 0.093). Hydroxyproline concentration did not differ significantly in between the groups. The adhesion score was 2.5 (range = 1-3) in the Experimental Group, 2 (range = 1-2) in the End Group, but there were significantly more adhesions in the Side Group (range = 3-4); p = 0.020 versus Experimental Group, p < 0.001 versus End Group. The Chiu Score showed the worst mucosal healing in the Experimental Group. The overall Verhofstad Score was significantly worse (mean = 2.032; standard deviation [SD] = 0.842) p = 0.031 and p = 0.002 in the Experimental Group, compared with the Side Group (mean = 1.729; SD = 0.682) and the End Group (mean = 1.571; SD = 0.612). The new anastomotic technique is feasible and did not show any relevant complication. Even though it was superior to the side-to-side anastomosis by trend with

  2. 49 CFR 389.15 - Contents of notices of proposed rule making.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Contents of notices of proposed rule making. 389.15 Section 389.15 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... § 389.15 Contents of notices of proposed rule making. (a) Each notice of proposed rule making is...

  3. 49 CFR 389.15 - Contents of notices of proposed rule making.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Contents of notices of proposed rule making. 389.15 Section 389.15 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... § 389.15 Contents of notices of proposed rule making. (a) Each notice of proposed rule making is...

  4. Smoke-free home and vehicle rules by tobacco use status among US adults.

    PubMed

    Kruger, Judy; Jama, Amal; Homa, David M; Babb, Stephen D; King, Brian A

    2015-09-01

    To assess the prevalence and characteristics of smoke-free home and vehicle rules by tobacco use. Data came from the 2012-2013 National Adult Tobacco Survey, a telephone survey of adults aged ≥18. Respondents who reported smoking is 'never allowed' inside their home or any family vehicle were considered to have smoke-free home and vehicle rules, respectively. Prevalence and characteristics of smoke-free rules were assessed overall and by current tobacco use (combustible only, noncombustible only, combustible and noncombustible, no current tobacco use). Assessed characteristics included: sex, age, race/ethnicity, education, marital status, income, region, and sexual orientation. Nationally, 83.7% of adults (n=48,871) had smoke-free home rules and 78.1% (n=46,183) had smoke-free vehicle rules. By tobacco use, prevalence was highest among nonusers of tobacco (homes: 90.8%; vehicles: 88.9%) and lowest among combustible-only users (homes: 53.7%; vehicles: 34.2%). Prevalence of smoke-free home and vehicle rules was higher among males, adults with a graduate degree, and adults living in the West. Most adults have smoke-free home and vehicle rules, but differences exist by tobacco use. Opportunities exist to educate adults about the dangers of secondhand smoke and the benefits of smoke-free environments, particularly among combustible tobacco users. Published by Elsevier Inc.

  5. End-of-life expectations and experiences among nursing home patients and their relatives--a synthesis of qualitative studies.

    PubMed

    Fosse, Anette; Schaufel, Margrethe Aase; Ruths, Sabine; Malterud, Kirsti

    2014-10-01

    Synthesize research about patients' and relatives' expectations and experiences on how doctors can improve end-of-life care in nursing homes. We systematically searched qualitative studies in English in seven databases (Medline, Embase, PsycINFO, CINAHL, Ageline, Cochrane Systematic Reviews and Cochrane Trials). We included 14 publications in the analysis with meta-ethnography. Patients and families emphasized the importance of health personnel anticipating illness trajectories and recognizing the information and palliation needed. Family members who became proxy decision-makers reported uncertainty and distress when guidance from health personnel was lacking. They worried about staff shortage and emphasized doctor availability. Relatives and health personnel seldom recognized patients' ability to consent, and patients' preferences were not always recognized. Nursing home patients and their relatives wanted doctors more involved in end-of-life care. They expected doctors to acknowledge their preferences and provide guidance and symptom relief. High-quality end-of-life care in nursing homes relies on organization, funding and skilled staff, including available doctors who are able to recognize illness trajectories and perform individualized Advance Care Planning. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  6. Qiang-Dong proper quantization rule and its applications to exactly solvable quantum systems

    NASA Astrophysics Data System (ADS)

    Serrano, F. A.; Gu, Xiao-Yan; Dong, Shi-Hai

    2010-08-01

    We propose proper quantization rule, ∫x_Ax_B k(x)dx-∫x0Ax0Bk0(x)dx=nπ, where k(x )=√2M[E -V(x)] /ℏ. The xA and xB are two turning points determined by E =V(x), and n is the number of the nodes of wave function ψ(x ). We carry out the exact solutions of solvable quantum systems by this rule and find that the energy spectra of solvable systems can be determined only from its ground state energy. The previous complicated and tedious integral calculations involved in exact quantization rule are greatly simplified. The beauty and simplicity of the rule come from its meaning—whenever the number of the nodes of ϕ(x ) or the number of the nodes of the wave function ψ(x ) increases by 1, the momentum integral ∫xAxBk(x )dx will increase by π. We apply this proper quantization rule to carry out solvable quantum systems such as the one-dimensional harmonic oscillator, the Morse potential and its generalization, the Hulthén potential, the Scarf II potential, the asymmetric trigonometric Rosen-Morse potential, the Pöschl-Teller type potentials, the Rosen-Morse potential, the Eckart potential, the harmonic oscillator in three dimensions, the hydrogen atom, and the Manning-Rosen potential in D dimensions.

  7. The symmetry rule: a seven-year study of symptoms and explanatory labels among Gulf War veterans.

    PubMed

    Brewer, Noel T; Hallman, William K; Kipen, Howard M

    2008-12-01

    Noticing medical symptoms can cause one to search for explanatory labels such as "ate bad food" or even "exposed to anthrax," and perhaps these labels may cause new symptom reports. The present study examined whether there is empirical support for this symptom-label "symmetry rule." We interviewed veterans (N= 362) from the Gulf War Registry in 1995 and 2002 about their medical symptoms and about their exposure to war-related hazards and stressors. Health symptom reports were strongly correlated between the two time periods and showed relatively stable mean levels, whereas recall of war-related exposures was notably unstable. Veterans starting with fewer medical symptoms recalled fewer war-related exposures seven years later. Initial recollection of chemical and biological warfare exposure (but not other exposures) longitudinally predicted novel medical symptoms. The findings generally support the symmetry rule hypotheses, although the evidence for the label to symptom link was less strong. The findings account for some variability in symptoms and exposure recall over time, but they do not, on their own, account for the Gulf War veterans' elevated number of unexplained medical symptoms.

  8. 29 CFR 1626.22 - Rules to be liberally construed.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.22 Rules to be liberally construed. (a) These rules and regulations shall... is filed under one statute and it is subsequently believed that the alleged discrimination...

  9. 29 CFR 1626.22 - Rules to be liberally construed.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.22 Rules to be liberally construed. (a) These rules and regulations shall... is filed under one statute and it is subsequently believed that the alleged discrimination...

  10. Outcomes of liver transplantation for end-stage biliary disease: A comparative study with end-stage liver disease.

    PubMed

    Lai, Yan-Hua; Duan, Wei-Dong; Yu, Qiang; Ye, Sheng; Xiao, Nian-Jun; Zhang, Dong-Xin; Huang, Zhi-Qiang; Yang, Zhan-Yu; Dong, Jia-Hong

    2015-05-28

    To evaluate the outcomes of patients with end-stage biliary disease (ESBD) who underwent liver transplantation, to define the concept of ESBD, the criteria for patient selection and the optimal operation for decision-making. Between June 2002 and June 2014, 43 patients with ESBD from two Chinese organ transplantation centres were evaluated for liver transplantation. The causes of liver disease were primary biliary cirrhosis (n = 8), cholelithiasis (n = 8), congenital biliary atresia (n = 2), graft-related cholangiopathy (n = 18), Caroli's disease (n = 2), iatrogenic bile duct injury (n = 2), primary sclerosing cholangitis (n = 1), intrahepatic bile duct paucity (n = 1) and Alagille's syndrome (n = 1). The patients with ESBD were compared with an end-stage liver disease (ESLD) case control group during the same period, and the potential prognostic values of multiple demographic and clinical variables were assessed. The examined variables included recipient age, sex, pre-transplant clinical status, pre-transplant laboratory values, operation condition and postoperative complications, as well as patient and allograft survival rates. Survival analysis was performed using Kaplan-Meier curves, and the rates were compared using log-rank tests. All variables identified by univariate analysis with P values < 0.100 were subjected to multivariate analysis. A Cox proportional hazard regression model was used to determine the effect of the study variables on outcomes in the study group. Patients in the ESBD group had lower model for end-stage liver disease (MELD)/paediatric end-stage liver disease (PELD) scores and a higher frequency of previous abdominal surgery compared to patients in the ESLD group (19.2 ± 6.6 vs 22.0 ± 6.5, P = 0.023 and 1.8 ± 1.3 vs 0.1 ± 0.2, P = 0.000). Moreover, the operation time and the time spent in intensive care were significantly higher in the ESBD group than in the ESLD group (527.4 ± 98.8 vs 443.0 ± 101.0, P = 0.000, and 12.74 ± 6.6 vs 10

  11. 75 FR 44042 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... submit order execution reports to the Exchange's Front End Systemic Capture (``FESC'') database linking... that would apply across their respective marketplaces, including a harmonized approach to riskless... approach to customer order protection rules, including how riskless principal transactions should be...

  12. 26 CFR 601.201 - Rulings and determinations letters.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

  13. 26 CFR 601.201 - Rulings and determinations letters.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

  14. 26 CFR 601.201 - Rulings and determinations letters.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

  15. 26 CFR 601.201 - Rulings and determinations letters.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

  16. 26 CFR 601.201 - Rulings and determinations letters.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

  17. 75 FR 10858 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... LLC Amending NYSE Amex Rule 476 To Add a Provision for Violations Relating To Failing to Observe High... Rule 476 to add a provision for violations relating to failing to observe high standards of commercial... ``Exchange'') proposes to amend NYSE Amex Rule 476 to add a provision for violations relating to failing to...

  18. Using global sensitivity analysis to evaluate the uncertainties of future shoreline changes under the Bruun rule assumption

    NASA Astrophysics Data System (ADS)

    Le Cozannet, Gonéri; Oliveros, Carlos; Castelle, Bruno; Garcin, Manuel; Idier, Déborah; Pedreros, Rodrigo; Rohmer, Jeremy

    2016-04-01

    Future sandy shoreline changes are often assed by summing the contributions of longshore and cross-shore effects. In such approaches, a contribution of sea-level rise can be incorporated by adding a supplementary term based on the Bruun rule. Here, our objective is to identify where and when the use of the Bruun rule can be (in)validated, in the case of wave-exposed beaches with gentle slopes. We first provide shoreline change scenarios that account for all uncertain hydrosedimentary processes affecting the idealized low- and high-energy coasts described by Stive (2004)[Stive, M. J. F. 2004, How important is global warming for coastal erosion? an editorial comment, Climatic Change, vol. 64, n 12, doi:10.1023/B:CLIM.0000024785.91858. ISSN 0165-0009]. Then, we generate shoreline change scenarios based on probabilistic sea-level rise projections based on IPCC. For scenario RCP 6.0 and 8.5 and in the absence of coastal defenses, the model predicts an observable shift toward generalized beach erosion by the middle of the 21st century. On the contrary, the model predictions are unlikely to differ from the current situation in case of scenario RCP 2.6. To get insight into the relative importance of each source of uncertainties, we quantify each contributions to the variance of the model outcome using a global sensitivity analysis. This analysis shows that by the end of the 21st century, a large part of shoreline change uncertainties are due to the climate change scenario if all anthropogenic greenhousegas emission scenarios are considered equiprobable. To conclude, the analysis shows that under the assumptions above, (in)validating the Bruun rule should be straightforward during the second half of the 21st century and for the RCP 8.5 scenario. Conversely, for RCP 2.6, the noise in shoreline change evolution should continue dominating the signal due to the Bruun effect. This last conclusion can be interpreted as an important potential benefit of climate change mitigation.

  19. Medicare program; revision to accrual basis of accounting policy--HCFA. Proposed rule.

    PubMed

    1998-05-18

    Current policy provides that payroll taxes a provider becomes obligated to remit to governmental agencies are included in allowable costs under Medicare only in the cost reporting period in which payment (upon which the payroll taxes are based) is actually made to an employee. Therefore, for payroll accrued in one year but not paid until the next year, the associated payroll taxes on the payroll are not an allowable cost until the next year. This proposed rule would make one exception, in the situation where payment would be made to the employee in the current year but for the fact the regularly scheduled payment date is after the end of the year. In that case, the rule would require allowance in the current year of accrued taxes on payroll that is accrued through the end of the year but not paid until the beginning of the next year, thus allowing accrued taxes on end-of-the year payroll in the same year that the accrual of the payroll itself is allowed. The effect of this proposal is not on the allowability of cost but rather only on the timing of payment; that is, the cost of payroll taxes on and-of-the-year payroll would be allowable in the current period rather than in the following period.

  20. Severity of influenza A 2009 (H1N1) pneumonia is underestimated by routine prediction rules. Results from a prospective, population-based study.

    PubMed

    Bjarnason, Agnar; Thorleifsdottir, Gudlaug; Löve, Arthur; Gudnason, Janus F; Asgeirsson, Hilmir; Hallgrimsson, Kristinn L; Kristjansdottir, Berglind S; Haraldsson, Gunnsteinn; Baldursson, Olafur; Kristinsson, Karl G; Gottfredsson, Magnus

    2012-01-01

    Characteristics of patients with community-acquired pneumonia (CAP) due to pandemic influenza A 2009 (H1N1) have been inadequately compared to CAP caused by other respiratory pathogens. The performance of prediction rules for CAP during an epidemic with a new infectious agent are unknown. Prospective, population-based study from November 2008-November 2009, in centers representing 70% of hospital beds in Iceland. Patients admitted with CAP underwent evaluation and etiologic testing, including polymerase chain reaction (PCR) for influenza. Data on influenza-like illness in the community and overall hospital admissions were collected. Clinical and laboratory data, including pneumonia severity index (PSI) and CURB-65 of patients with CAP due to H1N1 were compared to those caused by other agents. Of 338 consecutive and eligible patients 313 (93%) were enrolled. During the pandemic peak, influenza A 2009 (H1N1) patients constituted 38% of admissions due to CAP. These patients were younger, more dyspnoeic and more frequently reported hemoptysis. They had significantly lower severity scores than other patients with CAP (1.23 vs. 1.61, P= .02 for CURB-65, 2.05 vs. 2.87 for PSI, P<.001) and were more likely to require intensive care admission (41% vs. 5%, P<.001) and receive mechanical ventilation (14% vs. 2%, P= .01). Bacterial co-infection was detected in 23% of influenza A 2009 (H1N1) patients with CAP. Clinical characteristics of CAP caused by influenza A 2009 (H1N1) differ markedly from CAP caused by other etiologic agents. Commonly used CAP prediction rules often failed to predict admissions to intensive care or need for assisted ventilation in CAP caused by the influenza A 2009 (H1N1) virus, underscoring the importance of clinical acumen under these circumstances.

  1. Severity of Influenza A 2009 (H1N1) Pneumonia Is Underestimated by Routine Prediction Rules. Results from a Prospective, Population-Based Study

    PubMed Central

    Bjarnason, Agnar; Thorleifsdottir, Gudlaug; Löve, Arthur; Gudnason, Janus F.; Asgeirsson, Hilmir; Hallgrimsson, Kristinn L.; Kristjansdottir, Berglind S.; Haraldsson, Gunnsteinn; Baldursson, Olafur; Kristinsson, Karl G.; Gottfredsson, Magnus

    2012-01-01

    Background Characteristics of patients with community-acquired pneumonia (CAP) due to pandemic influenza A 2009 (H1N1) have been inadequately compared to CAP caused by other respiratory pathogens. The performance of prediction rules for CAP during an epidemic with a new infectious agent are unknown. Methods Prospective, population-based study from November 2008–November 2009, in centers representing 70% of hospital beds in Iceland. Patients admitted with CAP underwent evaluation and etiologic testing, including polymerase chain reaction (PCR) for influenza. Data on influenza-like illness in the community and overall hospital admissions were collected. Clinical and laboratory data, including pneumonia severity index (PSI) and CURB-65 of patients with CAP due to H1N1 were compared to those caused by other agents. Results Of 338 consecutive and eligible patients 313 (93%) were enrolled. During the pandemic peak, influenza A 2009 (H1N1) patients constituted 38% of admissions due to CAP. These patients were younger, more dyspnoeic and more frequently reported hemoptysis. They had significantly lower severity scores than other patients with CAP (1.23 vs. 1.61, P = .02 for CURB-65, 2.05 vs. 2.87 for PSI, P<.001) and were more likely to require intensive care admission (41% vs. 5%, P<.001) and receive mechanical ventilation (14% vs. 2%, P = .01). Bacterial co-infection was detected in 23% of influenza A 2009 (H1N1) patients with CAP. Conclusions Clinical characteristics of CAP caused by influenza A 2009 (H1N1) differ markedly from CAP caused by other etiologic agents. Commonly used CAP prediction rules often failed to predict admissions to intensive care or need for assisted ventilation in CAP caused by the influenza A 2009 (H1N1) virus, underscoring the importance of clinical acumen under these circumstances. PMID:23071646

  2. 29 CFR 1620.34 - Rules to be liberally construed.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.34 Rules to be liberally construed. (a) These rules and regulations shall be liberally construed to effectuate the purpose and provisions of this Act and any other Act administered by the...

  3. Dissociable roles of medial and lateral PFC in rule learning.

    PubMed

    Cao, Bihua; Li, Wei; Li, Fuhong; Li, Hong

    2016-11-01

    Although the neural basis of rule learning is of great interest to cognitive neuroscientists, the pattern of transient brain activation during rule discovery remains to be investigated. In this study, we measured event-related functional magnetic resonance imaging (fMRI) during distinct phases of rule learning. Twenty-one healthy human volunteers were presented with a series of cards, each containing a clock-like display of 12 circles numbered sequentially. Participants were instructed that a fictitious animal would move from one circle to another either in a regular pattern (according to a rule hidden in consecutive trials) or randomly. Participants were then asked to judge whether a given step followed a rule. While the rule-search phase evoked more activation in the posterior lateral prefrontal cortex (LPFC), the rule-following phase caused stronger activation in the anterior medial prefrontal cortex (MPFC). Importantly, the intermediate phase, the rule-discovery phase evoked more activations in MPFC and dorsal anterior cingulate cortex (dACC) than rule search, and more activations in LPFC than rule following. Therefore, we can conclude that the medial and lateral PFC have dissociable contributions in rule learning.

  4. 40 CFR Appendix M to Subpart G - Unacceptable Substitutes Listed in the September 30, 2004 Final Rule, Effective November 29, 2004

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... —Rigid polyurethane slabstock and other foams —Polystyrene extruded insulation boardstock and billet...—Unacceptable Substitutes Listed in the September 30, 2004 Final Rule, Effective November 29, 2004 Foam Blowing—Unacceptable Substitutes End-use Substitute Decision Comments All foam end-uses: HCFC-141b Unacceptable...

  5. 40 CFR Appendix M to Subpart G - Unacceptable Substitutes Listed in the September 30, 2004 Final Rule, Effective November 29, 2004

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... —Rigid polyurethane slabstock and other foams —Polystyrene extruded insulation boardstock and billet...—Unacceptable Substitutes Listed in the September 30, 2004 Final Rule, Effective November 29, 2004 Foam Blowing—Unacceptable Substitutes End-use Substitute Decision Comments All foam end-uses: HCFC-141b Unacceptable...

  6. 40 CFR Appendix M to Subpart G - Unacceptable Substitutes Listed in the September 30, 2004 Final Rule, Effective November 29, 2004

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... —Rigid polyurethane slabstock and other foams —Polystyrene extruded insulation boardstock and billet...—Unacceptable Substitutes Listed in the September 30, 2004 Final Rule, Effective November 29, 2004 Foam Blowing—Unacceptable Substitutes End-use Substitute Decision Comments All foam end-uses: HCFC-141b Unacceptable...

  7. Engineering the N-terminal end of CelA results in improved performance and growth of Caldicellulosiruptor bescii on crystalline cellulose

    DOE PAGES

    Kim, Sun -Ki; Chung, Daehwan; Himmel, Michael E.; ...

    2016-12-26

    Here, CelA is the most abundant enzyme secreted by Caldicellulosiruptor bescii and has been shown to outperform mixtures of commercially available exo- and endoglucanases in vitro. CelA contains both a glycoside hydrolase family 9 endoglucanase and a glycoside hydrolase family 48 exoglucanase known to be synergistic in their activity, connected by three cellulose-binding domains via linker peptides. Here, repeated aspartate residues were introduced into the N-terminal ends of CelA GH9 and GH48 domains to improve secretion efficiency and/or catalytic efficiency of CelA. Among several constructs, the highest activity on carboxymethylcellulose (CMC), 0.81 ± 0.03 mg/mL was observed for the C.more » bescii strain containing CelA with 5-aspartate tag at the N-terminal end of GH9 domain – an 82% increase over wild type CelA. In addition, Expression of CelA with N-terminal repeated aspartate residues in C. bescii results in a dramatic increase in its ability to grow on Avicel.« less

  8. 29 CFR 1978.115 - Special circumstances; waiver of rules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Special circumstances; waiver of rules. 1978.115 Section 1978.115 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... parties and intervenors, waive any rule or issue such orders as justice or the administration of section...

  9. 29 CFR 1979.114 - Special circumstances; waiver of rules.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Special circumstances; waiver of rules. 1979.114 Section 1979.114 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION..., upon application, after three days notice to all parties and interveners, waive any rule or issue any...

  10. Parental Rule Socialization for Preventive Health and Adolescent Rule Compliance

    ERIC Educational Resources Information Center

    Bylund, Carma L.; Baxter, Leslie A.; Imes, Rebecca S.; Wolf, Bianca

    2010-01-01

    This study examined family rules about nutrition, exercise, and sun protection in 164 parent-young adult children dyads. Both parents and their young adult children independently reported on health rules that they perceived throughout their child's adolescent years and the extent to which the rules were articulated, violations sanctioned, and…

  11. Bilinearity, Rules, and Prefrontal Cortex

    PubMed Central

    Dayan, Peter

    2007-01-01

    Humans can be instructed verbally to perform computationally complex cognitive tasks; their performance then improves relatively slowly over the course of practice. Many skills underlie these abilities; in this paper, we focus on the particular question of a uniform architecture for the instantiation of habitual performance and the storage, recall, and execution of simple rules. Our account builds on models of gated working memory, and involves a bilinear architecture for representing conditional input-output maps and for matching rules to the state of the input and working memory. We demonstrate the performance of our model on two paradigmatic tasks used to investigate prefrontal and basal ganglia function. PMID:18946523

  12. 42 CFR 50.303 - General rule.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.303 General rule. Federal financial participation is not available for the performance of an abortion in...

  13. 42 CFR 50.303 - General rule.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.303 General rule. Federal financial participation is not available for the performance of an abortion in...

  14. 42 CFR 50.303 - General rule.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.303 General rule. Federal financial participation is not available for the performance of an abortion in...

  15. 42 CFR 50.303 - General rule.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.303 General rule. Federal financial participation is not available for the performance of an abortion in...

  16. 42 CFR 50.303 - General rule.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.303 General rule. Federal financial participation is not available for the performance of an abortion in...

  17. Cell Phones: Rule-Setting, Rule-Breaking, and Relationships in Classrooms

    ERIC Educational Resources Information Center

    Charles, Anita S.

    2012-01-01

    Based on a small qualitative study, this article focuses on understanding the rules for cell phones and other social networking media in schools, an aspect of broader research that led to important understandings of teacher-student negotiations. It considers the rules that schools and teachers make, the rampant breaking of these rules, the…

  18. 76 FR 8961 - Rules on Source, Origin and Nationality for Commodities and Services Financed by USAID

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... AGENCY FOR INTERNATIONAL DEVELOPMENT 22 CFR Part 228 RIN 0412-AA70 Rules on Source, Origin and... solicit comments on whether changes are needed to USAID's rules on Source, Origin, and Nationality (S/O/N... rules in order to reduce the burden of procurement processes for USAID and contractors and grantees...

  19. The Effect of the "Zero Tolerance for Head Contact" Rule Change on the Risk of Concussions in Youth Ice Hockey Players.

    PubMed

    Krolikowski, Maciej P; Black, Amanda M; Palacios-Derflingher, Luz; Blake, Tracy A; Schneider, Kathryn J; Emery, Carolyn A

    2017-02-01

    Ice hockey is a popular winter sport in Canada. Concussions account for the greatest proportion of all injuries in youth ice hockey. In 2011, a policy change enforcing "zero tolerance for head contact" was implemented in all leagues in Canada. To determine if the risk of game-related concussions and more severe concussions (ie, resulting in >10 days of time loss) and the mechanisms of a concussion differed for Pee Wee class (ages 11-12 years) and Bantam class (ages 13-14 years) players after the 2011 "zero tolerance for head contact" policy change compared with players in similar divisions before the policy change. Cohort study; Level of evidence, 3. The retrospective cohort included Pee Wee (most elite 70%, 2007-2008; n = 891) and Bantam (most elite 30%, 2008-2009; n = 378) players before the rule change and Pee Wee (2011-2012; n = 588) and Bantam (2011-2012; n = 242) players in the same levels of play after the policy change. Suspected concussions were identified by a team designate and referred to a sport medicine physician for diagnosis. Incidence rate ratios (IRRs) were estimated based on multiple Poisson regression analysis, controlling for clustering by team and other important covariates and offset by game-exposure hours. Incidence rates based on the mechanisms of a concussion were estimated based on univariate Poisson regression analysis. The risk of game-related concussions increased after the head contact rule in Pee Wee (IRR, 1.85; 95% CI, 1.20-2.86) and Bantam (IRR, 2.48; 95% CI, 1.17-5.24) players. The risk of more severe concussions increased after the head contact rule in Pee Wee (IRR, 4.12; 95% CI, 2.00-8.50) and Bantam (IRR, 7.91; 95% CI, 3.13-19.94) players. The rates of concussions due to body checking and direct head contact increased after the rule change. The "zero tolerance for head contact" policy change did not reduce the risk of game-related concussions in Pee Wee or Bantam class ice hockey players. Increased concussion awareness and

  20. Ruling out coronary artery disease in primary care: development and validation of a simple prediction rule.

    PubMed

    Bösner, Stefan; Haasenritter, Jörg; Becker, Annette; Karatolios, Konstantinos; Vaucher, Paul; Gencer, Baris; Herzig, Lilli; Heinzel-Gutenbrunner, Monika; Schaefer, Juergen R; Abu Hani, Maren; Keller, Heidi; Sönnichsen, Andreas C; Baum, Erika; Donner-Banzhoff, Norbert

    2010-09-07

    Chest pain can be caused by various conditions, with life-threatening cardiac disease being of greatest concern. Prediction scores to rule out coronary artery disease have been developed for use in emergency settings. We developed and validated a simple prediction rule for use in primary care. We conducted a cross-sectional diagnostic study in 74 primary care practices in Germany. Primary care physicians recruited all consecutive patients who presented with chest pain (n = 1249) and recorded symptoms and findings for each patient (derivation cohort). An independent expert panel reviewed follow-up data obtained at six weeks and six months on symptoms, investigations, hospital admissions and medications to determine the presence or absence of coronary artery disease. Adjusted odds ratios of relevant variables were used to develop a prediction rule. We calculated measures of diagnostic accuracy for different cut-off values for the prediction scores using data derived from another prospective primary care study (validation cohort). The prediction rule contained five determinants (age/sex, known vascular disease, patient assumes pain is of cardiac origin, pain is worse during exercise, and pain is not reproducible by palpation), with the score ranging from 0 to 5 points. The area under the curve (receiver operating characteristic curve) was 0.87 (95% confidence interval [CI] 0.83-0.91) for the derivation cohort and 0.90 (95% CI 0.87-0.93) for the validation cohort. The best overall discrimination was with a cut-off value of 3 (positive result 3-5 points; negative result rule for coronary artery disease in primary care proved to be robust in the validation cohort. It can help to rule out coronary artery disease in patients presenting with chest pain in primary care.

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