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Sample records for nanofabrication from ultralarge-scale integration

  1. Thin-Film Transistor and Ultra-Large Scale Integrated Circuit: Competition or Collaboration

    NASA Astrophysics Data System (ADS)

    Kuo, Yue

    2008-03-01

    Thin-film transistor (TFT) and ultra-large scale integrated circuit (ULSIC) have been compared and discussed with respect to the development history, technology trends, and applications. Detailed issues on materials, processes, and devices in the large-area TFT array fabrication and nano-size metal-oxide-semiconductor field effect transistors (MOSFETs) composed ULSIC on large wafers were also examined. The TFT fabrication processes were originally derived from ULSIC. However, there are many unique large-area processes and theories developed during the study of the TFT array fabrication, which can greatly benefit the future large wafer ULSIC production process. Although their future applications will be in different areas, there are opportunities that TFTs can be integrated into ULSIC products to enhance the functions and performance.

  2. Nanofabrication

    DOEpatents

    Tuominen, Mark; Bal, Mustafa; Russell, Thomas P.; Ursache, Andrei

    2007-03-13

    Pathways to rapid and reliable fabrication of three-dimensional nanostructures are provided. Simple methods are described for the production of well-ordered, multilevel nanostructures. This is accomplished by patterning block copolymer templates with selective exposure to a radiation source. The resulting multi-scale lithographic template can be treated with post-fabrication steps to produce multilevel, three-dimensional, integrated nanoscale media, devices, and systems.

  3. Cosmology on Ultralarge Scales with Intensity Mapping of the Neutral Hydrogen 21 cm Emission: Limits on Primordial Non-Gaussianity

    NASA Astrophysics Data System (ADS)

    Camera, Stefano; Santos, Mário G.; Ferreira, Pedro G.; Ferramacho, Luís

    2013-10-01

    The large-scale structure of the Universe supplies crucial information about the physical processes at play at early times. Unresolved maps of the intensity of 21 cm emission from neutral hydrogen HI at redshifts z≃1-5 are the best hope of accessing the ultralarge-scale information, directly related to the early Universe. A purpose-built HI intensity experiment may be used to detect the large scale effects of primordial non-Gaussianity, placing stringent bounds on different models of inflation. We argue that it may be possible to place tight constraints on the non-Gaussianity parameter fNL, with an error close to σfNL˜1.

  4. Electron beam deposition for nanofabrication: Insights from surface science

    NASA Astrophysics Data System (ADS)

    Wnuk, J. D.; Rosenberg, S. G.; Gorham, J. M.; van Dorp, W. F.; Hagen, C. W.; Fairbrother, D. H.

    2011-02-01

    Electron beam induced deposition (EBID) is a direct-write lithographic technique that utilizes the dissociation of volatile precursors by a focused electron beam in a low vacuum environment to create nanostructures. Notable advantages of EBID over competing lithographic techniques are that it is a single step process that allows three-dimensional free-standing structures to be created, including features with single-nanometer scale dimensions. However, despite the inherent advantages of EBID, scientific and technological issues are impeding its development as an industrial nanofabrication tool. Perhaps the greatest single limitation of EBID is that metal-containing nanostructures deposited from organometallic precursors typically possess unacceptable levels of organic contamination which adversely affects the material's properties. In addition to the issue of purity, there is also a lack of understanding and quantitative information on the fundamental surface reactions and reaction cross-sections that are responsible for EBID. In this prospective, we describe how surface analytical techniques have begun to provide mechanistic and kinetic insights into the molecular level processes associated with EBID. This has been achieved by observing the effect of electron irradiation on nanometer thick films of organometallic precursors adsorbed onto solid substrates at low temperatures (< 200 K) under ultra-high vacuum conditions. Experimental observations include probing changes in surface composition, metal oxidation state, and the evolution of volatile species. Insights into surface reactions associated with purification strategies are also detailed. We also discuss unresolved scientific challenges and opportunities for future EBID research.

  5. From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

    PubMed Central

    Wang, Wei

    2010-01-01

    This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and from nanoparticles to self-assembled molecules. Meanwhile a great number of novel methodologies, employing off-the-shelf consumer electronics, intriguing interfacial phenomena, bottom-up self-assembly principles, etc., have been implemented to transit micro-nanofabrication from a cleanroom environment to a desktop setup. Furthermore, the latest application of micro-nanofabrication to emerging biomedical research will be presented in detail, which includes point-of-care diagnostics, on-chip cell culture as well as bio-manipulation. While significant progresses have been made in the rapidly growing field, both apparent and unrevealed roadblocks will need to be addressed in the future. We conclude this review by offering our perspectives on the current technical challenges and future research opportunities. PMID:21161384

  6. Programming reaction-diffusion: From theory to micro- and nanofabrication

    NASA Astrophysics Data System (ADS)

    Campbell, Christopher James

    Nature often uses reaction-diffusion(RD) as a means of making structures and materials of unique properties or morphologies on scales from macro- (e.g., stripes in zebras, tigers, and seashells, and formations in trees, agates, and rocks) to microscopic (e.g., cellular growth, chemotaxis and biological waves). However, reaction-diffusion phenomena have not yet been applied in modern materials science and micro-/nanotechnology. In this context, RD systems are particularly promising for micropatterning of surfaces. Unlike conventional micropatterning techniques that modify the properties of the substrate only at the locations to which a modifying agent - be it a chemical or radiation - is delivered, RD can, in principle, evolve chemicals delivered onto a surface into structures of characteristic dimensions significantly smaller than those of the original pattern. In this Dissertation, I describe how reaction-diffusions are programmed and executed via a new micropatterning technique called Wet Stamping to (i) transform microscopic patterns of chemicals delivered onto thin films of dry gelatin into regular arrays of lines of submicrometer thicknesses, multicolor arrays on the micrometer scale, or three-dimensional microstructured surfaces; (ii) modify the properties of a surface by precisely delivering an oxidant to change hydrophilicity or deliver silanes or thiols to build a self-assembling monolayer; or (iii) cut into a metal, glass, or crystal surface by delivery of an etchant to form binary and curvilinear three-dimensional microstructures. This technique has allowed for a fundamental understanding and control of reaction-diffusion processes down to the nanoscale. In addition, this platform has allowed for the development of a range of applications on the micro- and nanoscale, including microlenses, microfluidic devices, and templates for studying cell motility and cancer metastasis.

  7. Nanomanipulation and nanofabrication with multi-probe STM: From individual atoms to nanowires

    SciTech Connect

    Qin, Shengyong; Kim, Tae Hwan; Wang, Zhouhang; Li, An-Ping

    2012-01-01

    The wide variety of nanoscale structures and devices demands novel tools for handling, assembly, and fabrication at nanoscopic positioning precision. The manipulation tools should allow for in situ characterization and testing of fundamental building blocks, such as nanotubes and nanowires, as they are built into functional devices. In this paper, a bottom-up technique for nanomanipulation and nanofabrication is reported by using a 4-probe scanning tunneling microscope (STM) combined with a scanning electron microscope (SEM). The applications of this technique are demonstrated in a variety of nanosystems, from manipulating individual atoms to bending, cutting, breaking carbon nanofibers, and constructing nanodevices for electrical characterizations. The combination of the wide field of view of SEM, the atomic position resolution of STM, and the flexibility of multiple scanning probes is expected to be a valuable tool for rapid prototyping in the nanoscience and nanotechnology.

  8. Stochastic inflation lattice simulations - Ultra-large scale structure of the universe

    NASA Technical Reports Server (NTRS)

    Salopek, D. S.

    1991-01-01

    Non-Gaussian fluctuations for structure formation may arise in inflation from the nonlinear interaction of long wavelength gravitational and scalar fields. Long wavelength fields have spatial gradients, a (exp -1), small compared to the Hubble radius, and they are described in terms of classical random fields that are fed by short wavelength quantum noise. Lattice Langevin calculations are given for a toy model with a scalar field interacting with an exponential potential where one can obtain exact analytic solutions of the Fokker-Planck equation. For single scalar field models that are consistent with current microwave background fluctuations, the fluctuations are Gaussian. However, for scales much larger than our observable Universe, one expects large metric fluctuations that are non-Gaussian. This example illuminates non-Gaussian models involving multiple scalar fields which are consistent with current microwave background limits.

  9. Controlling Magnetotactic Bacteria through an Integrated Nanofabricated Metallic Island and Optical Microscope Approach

    PubMed Central

    González, Lina M.; Ruder, Warren C.; Leduc, Philip R.; Messner, William C.

    2014-01-01

    Herein, we demonstrate the control of magnetotactic bacteria through the application of magnetic field gradients with real-time visualization. We accomplish this control by integrating a pair of macroscale Helmholtz coils and lithographically fabricated nanoscale islands composed of permalloy (Ni80Fe20). This system enabled us to guide and steer amphitrichous Magnetospirillum magneticum strain AMB-1 to specific location via magnetic islands. The geometries of the islands allowed us to have control over the specific magnetic field gradients on the bacteria. We estimate that magnetotactic bacteria located less than 1 μm from the edge of a diamond shaped island experience a maximum force of approximately 34 pN, which engages the bacteria without trapping them. Our system could be useful for a variety of applications including magnetic fabrication, self-assembly, and probing the sensing apparatus of magnetotactic bacteria. PMID:24553101

  10. An integrated portable Raman sensor with nanofabricated gold bowtie array substrates for energetics detection

    SciTech Connect

    Hatab, Nahla A.; Rouleau, Christopher; Retterer, Scott T; Eres, Gyula; Hatzinger, Paul B.; Gu, Baohua

    2011-01-01

    An integrated field-portable surface enhaned Raman scattering (SERS) sensing system has been developed and evaluated for quantitative analysis of energetics such as perchlorate (ClO4-) and trinitrotoluene (TNT) at environmentally-relevant concentrations and conditions. The detection system consists of a portable Raman spectrometer equipped with an optical fiber probe that is coupled with novel elevated gold bowtie nanostructural arrays as a sensitive and reproducible SERS substrate. Using the standard addition technique, we show that ClO4- and TNT can be quantified at concentrations as low as 0.66 mg/L (or ~6.6 M) and 0.20 mg/L (~0.9 M), respectively, in groundwater samples collected from selected military sites. This research represents the first step toward the development of a field SERS sensor which may permit rapid, in-situ screening and analysis for various applications including national security, chemical, biological and environmental detection.

  11. Micro/nanofabricated solid-state thermoelectric generator devices for integrated high voltage power sources

    NASA Technical Reports Server (NTRS)

    Fleurial, J. P.; Snyder, G. J.; Patel, J.; Huang, C. K.; Ryan, M. A.; Averback, R.; Chen, G.; Hill, C.

    2002-01-01

    The Jet Propulsion Laboratory has been actively pursuing the development of thermoelectric micro/nanodevices that can be fabricated using a combination of electrochemical deposition and integrated circuit processing techniques.

  12. Femtosecond laser 3D nanofabrication in glass: enabling direct write of integrated micro/nanofluidic chips

    NASA Astrophysics Data System (ADS)

    Cheng, Ya; Liao, Yang; Sugioka, Koji

    2014-03-01

    The creation of complex three-dimensional (3D) fluidic systems composed of hollow micro- and nanostructures embedded in transparent substrates has attracted significant attention from both scientific and applied research communities. However, it is by now still a formidable challenge to build 3D micro- and nanofluidic structures with arbitrary configurations using conventional planar lithographic fabrication methods. As a direct and maskless fabrication technique, femtosecond laser micromachining provides a straightforward approach for high-precision spatial-selective modification inside transparent materials through nonlinear optical absorption. Here, we demonstrate rapid fabrication of high-aspect-ratio micro- and/or nanofluidic structures with various 3D configurations in glass substrates by femtosecond laser direct writing. Based on this approach, we demonstrate several functional micro- and nanofluidic devices including a 3D passive microfluidic mixer, a capillary electrophoresis (CE) analysis chip, and an integrated micro-nanofluidic system for single DNA analysis. This technology offers new opportunities to develop novel 3D micro-nanofluidic systems for a variety of lab-on-a-chip applications.

  13. Reliability and microstructure of Al-Si-V-Pd alloy films for use in ultralarge scale integration

    NASA Astrophysics Data System (ADS)

    Dirks, A. G.; Augur, R. A.

    1994-02-01

    New data on a highly reliable interconnect material based on aluminum will be presented. As compared with conventional Al-Si-Cu alloy films, quaternary Al-Si-V-Pd films with only 0.1 at. % vanadium and 0.1 at. % palladium combine excellent plasma etchability with good corrosion resistance. Electromigration tests of Al-Si-V-Pd films have shown a surprisingly high stability at 180 °C. Studies of microstructural attributes show: (a) for Al-Si-V-Pd relative to Al-Si, texture is not significantly changed and average grain size is slightly increased, and (b) the dominant factor leading to a highly stable microstructure is the combined presence of finely dispersed, small precipitates of both (Al,V) and (Al,Pd) phases.

  14. Thermal plasmas for nanofabrication

    NASA Astrophysics Data System (ADS)

    Shigeta, Masaya; Murphy, Anthony B.

    2011-05-01

    In this paper, we review the recent progress in nanofabrication by thermal plasmas, and attempt to define some of the most important issues in the field. For synthesis of nanoparticles, the experimental studies in the past five years are briefly introduced; the theoretical and numerical modelling works of the past 20 years are reviewed with some detailed explanations. Also, the use of thermal plasmas to produce nanostructured films and coatings is described. A wide range of technologies have been developed, ranging from chemical vapour deposition processes to new plasma spraying processes. We present an overview of the different techniques and the important physical phenomena, as well as the requirements for future progress.

  15. Nanofabrication of SERS device by an integrated block-copolymer and nanoimprint lithography method.

    SciTech Connect

    Nealey, Paul; Liu, Charlie; Skinner, Jack L.; Yang, Elaine; Steinhaus, Charles A.; Yang, Chu-Yeu Peter

    2010-05-01

    The integration of block-copolymers (BCPs) and nanoimprint lithography (NIL) presents a novel and cost-effective approach to achieving nanoscale patterning capabilities. The authors demonstrate the fabrication of a surface-enhanced Raman scattering device using templates created by the BCP-NIL integrated method. The method utilizes a poly(styrene-block-methyl methacrylate) cylindrical-forming diblock-copolymer as a masking material to create a Si template, which is then used to perform a thermal imprint of a poly(methyl methacrylate) (PMMA) layer on a Si substrate. Au with a Cr adhesion layer was evaporated onto the patterned PMMA and the subsequent lift-off resulted in an array of nanodots. Raman spectra collected for samples of R6G on Si substrates with and without patterned nanodots showed enhancement of peak intensities due to the presence of the nanodot array. The demonstrated BCP-NIL fabrication method shows promise for cost-effective nanoscale fabrication of plasmonic and nanoelectronic devices.

  16. Hard and Soft Micro- and Nanofabrication: An Integrated Approach to Hydrogel Based Biosensing and Drug Delivery

    PubMed Central

    Siegel, Ronald A.; Gu, Yuandong; Lei, Ming; Baldi, Antonio; Nuxoll, Eric E.; Ziaie, Babak

    2010-01-01

    We review efforts to produce microfabricated glucose sensors and closed loop insulin delivery systems. These devices function due to the swelling and shrinking of glucose-sensitive microgels that are incorporated into silicon-based microdevices. The glucose response of the hydrogel is due to incorporated phenylboronic acid (PBA) side chains. It is shown that in the presence of glucose, these polymers alter their swelling properties, either by ionization or by formation of glucose-mediated reversible crosslinks. Swelling pressures impinge on microdevice structures, leading either to a change in resonant frequency of a microcircuit, or valving action. Potential areas for future development and improvement are described. Finally, an asymmetric nano-microporous membrane, which may be integrated with the glucose sensitive devices, is described. This membrane, formed using photolithography and block polymer assembly techniques, can be functionalized to enhance its biocompatibility and solute size selectivity. The work described here features the interplay of design considerations at the supramolecular, nano, and micro scales. PMID:20036310

  17. Nano-fabricated size exclusion chromatograph

    NASA Technical Reports Server (NTRS)

    Svehla, D.; Feldman, S.; Feldman, J.; Grunthaner, F.; Shakkottai, P.; Castillo, L. del; White, V.

    2002-01-01

    This paper describes the development of a nano-fabricated size exclusion chromatograph (nSEC) based on the principle that molecules traveling through amicrocolumn containing nano-fabricated features will have characteristic elution times that directly correlate to molecular weight. Compared to conventional size exclusion chromatography, the nSEC offers greater control over the size exclusion process; mass fabrication; integration of the separation column with associated valves, pumps, and detectors; and dramatic reductions in instrument mass and power requirements.

  18. Plasma nanofabrication and nanomaterials safety

    NASA Astrophysics Data System (ADS)

    Han, Z. J.; Levchenko, I.; Kumar, S.; Yajadda, M. M. A.; Yick, S.; Seo, D. H.; Martin, P. J.; Peel, S.; Kuncic, Z.; Ostrikov, K.

    2011-05-01

    The fast advances in nanotechnology have raised increasing concerns related to the safety of nanomaterials when exposed to humans, animals and the environment. However, despite several years of research, the nanomaterials safety field is still in its infancy owing to the complexities of structural and surface properties of these nanomaterials and organism-specific responses to them. Recently, plasma-based technology has been demonstrated as a versatile and effective way for nanofabrication, yet its health and environment-benign nature has not been widely recognized. Here we address the environmental and occupational health and safety effects of various zero- and one-dimensional nanomaterials and elaborate the advantages of using plasmas as a safe nanofabrication tool. These advantages include but are not limited to the production of substrate-bound nanomaterials, the isolation of humans from harmful nanomaterials, and the effective reforming of toxic and flammable gases. It is concluded that plasma nanofabrication can minimize the hazards in the workplace and represents a safe way for future nanofabrication technologies.

  19. Gravity at the horizon: on relativistic effects, CMB-LSS correlations and ultra-large scales in Horndeski's theory

    NASA Astrophysics Data System (ADS)

    Renk, Janina; Zumalacárregui, Miguel; Montanari, Francesco

    2016-07-01

    We address the impact of consistent modifications of gravity on the largest observable scales, focusing on relativistic effects in galaxy number counts and the cross-correlation between the matter large scale structure (LSS) distribution and the cosmic microwave background (CMB). Our analysis applies to a very broad class of general scalar-tensor theories encoded in the Horndeski Lagrangian and is fully consistent on linear scales, retaining the full dynamics of the scalar field and not assuming quasi-static evolution. As particular examples we consider self-accelerating Covariant Galileons, Brans-Dicke theory and parameterizations based on the effective field theory of dark energy, using the hi class code to address the impact of these models on relativistic corrections to LSS observables. We find that especially effects which involve integrals along the line of sight (lensing convergence, time delay and the integrated Sachs-Wolfe effect—ISW) can be considerably modified, and even lead to O(1000%) deviations from General Relativity in the case of the ISW effect for Galileon models, for which standard probes such as the growth function only vary by O(10%). These effects become dominant when correlating galaxy number counts at different redshifts and can lead to ~ 50% deviations in the total signal that might be observable by future LSS surveys. Because of their integrated nature, these deep-redshift cross-correlations are sensitive to modifications of gravity even when probing eras much before dark energy domination. We further isolate the ISW effect using the cross-correlation between LSS and CMB temperature anisotropies and use current data to further constrain Horndeski models. Forthcoming large-volume galaxy surveys using multiple-tracers will search for all these effects, opening a new window to probe gravity and cosmic acceleration at the largest scales available in our universe.

  20. Micro/nanofabricated environments for synthetic biology

    SciTech Connect

    Collier, Pat; Simpson, Michael L

    2011-01-01

    A better understanding of how confinement, crowding and reduced dimensionality modulate reactivity and reaction dynamics will aid in the rational and systematic discovery of functionality in complex biological systems. Artificial micro- and nanofabricated structures have helped elucidate the effects of nanoscale spatial confinement and segregation on biological behavior, particularly when integrated with microfluidics, through precise control in both space and time of diffusible signals and binding interactions. Examples of nanostructured interfaces for synthetic biology include the development of cell-like compartments for encapsulating biochemical reactions, nanostructured environments for fundamental studies of diffusion, molecular transport and biochemical reaction kinetics, and regulation of biomolecular interactions as functions of micro- and nanofabricated topological constraints.

  1. Ultra-large scale AFM of lipid droplet arrays: investigating the ink transfer volume in dip pen nanolithography

    NASA Astrophysics Data System (ADS)

    Förste, Alexander; Pfirrmann, Marco; Sachs, Johannes; Gröger, Roland; Walheim, Stefan; Brinkmann, Falko; Hirtz, Michael; Fuchs, Harald; Schimmel, Thomas

    2015-05-01

    There are only few quantitative studies commenting on the writing process in dip-pen nanolithography with lipids. Lipids are important carrier ink molecules for the delivery of bio-functional patters in bio-nanotechnology. In order to better understand and control the writing process, more information on the transfer of lipid material from the tip to the substrate is needed. The dependence of the transferred ink volume on the dwell time of the tip on the substrate was investigated by topography measurements with an atomic force microscope (AFM) that is characterized by an ultra-large scan range of 800 × 800 μm2. For this purpose arrays of dots of the phospholipid1,2-dioleoyl-sn-glycero-3-phosphocholine were written onto planar glass substrates and the resulting pattern was imaged by large scan area AFM. Two writing regimes were identified, characterized of either a steady decline or a constant ink volume transfer per dot feature. For the steady state ink transfer, a linear relationship between the dwell time and the dot volume was determined, which is characterized by a flow rate of about 16 femtoliters per second. A dependence of the ink transport from the length of pauses before and in between writing the structures was observed and should be taken into account during pattern design when aiming at best writing homogeneity. The ultra-large scan range of the utilized AFM allowed for a simultaneous study of the entire preparation area of almost 1 mm2, yielding good statistic results.

  2. MicroChannel Reactors for ISRU Applications Using Nanofabricated Catalysts

    NASA Astrophysics Data System (ADS)

    Carranza, Susana; Makel, Darby B.; Vander Wal, Randall L.; Berger, Gordon M.; Pushkarev, Vladimir V.

    2006-01-01

    With the new direction of NASA to emphasize the exploration of the Moon, Mars and beyond, quick development and demonstration of efficient systems for In-Situ Resources Utilization (ISRU) is more critical and timely than ever before. Affordable planning and execution of prolonged manned space missions depend upon the utilization of local resources and the waste products which are formed in manned spacecraft and surface bases. This paper presents current development of miniaturized chemical processing systems that combine microchannel reactor design with nanofabricated catalysts. Carbon nanotubes (CNT) are used to produce a nanostructure within microchannel reactors, as support for catalysts. By virtue of their nanoscale dimensions, nanotubes geometrically restrict the catalyst particle size that can be supported upon the tube walls. By confining catalyst particles to sizes smaller than the CNT diameter, a more uniform catalyst particle size distribution may be maintained. The high dispersion permitted by the vast surface area of the nanoscale material serves to retain the integrity of the catalyst by reducing sintering or coalescence. Additionally, catalytic efficiency increases with decreasing catalyst particle size (reflecting higher surface area per unit mass) while chemical reactivity frequently is enhanced at the nanoscale. Particularly significant is the catalyst exposure. Rather than being confined within a porous material or deposited upon a 2-d surface, the catalyst is fully exposed to the reactant gases by virtue of the nanofabricated support structure. The combination of microchannel technology with nanofabricated catalysts provides a synergistic effect, enhancing both technologies with the potential to produce much more efficient systems than either technology alone. The development of highly efficient microchannel reactors will be applicable to multiple ISRU programs. By selection of proper nanofabricated catalysts, the microchannel reactors can be

  3. Nanofabrication with Pulsed Lasers

    PubMed Central

    2010-01-01

    An overview of pulsed laser-assisted methods for nanofabrication, which are currently developed in our Institute (LP3), is presented. The methods compass a variety of possibilities for material nanostructuring offered by laser–matter interactions and imply either the nanostructuring of the laser-illuminated surface itself, as in cases of direct laser ablation or laser plasma-assisted treatment of semiconductors to form light-absorbing and light-emitting nano-architectures, as well as periodic nanoarrays, or laser-assisted production of nanoclusters and their controlled growth in gaseous or liquid medium to form nanostructured films or colloidal nanoparticles. Nanomaterials synthesized by laser-assisted methods have a variety of unique properties, not reproducible by any other route, and are of importance for photovoltaics, optoelectronics, biological sensing, imaging and therapeutics. PMID:20672069

  4. Nanofabrication with Pulsed Lasers

    NASA Astrophysics Data System (ADS)

    Kabashin, A. V.; Delaporte, Ph.; Pereira, A.; Grojo, D.; Torres, R.; Sarnet, Th.; Sentis, M.

    2010-03-01

    An overview of pulsed laser-assisted methods for nanofabrication, which are currently developed in our Institute (LP3), is presented. The methods compass a variety of possibilities for material nanostructuring offered by laser-matter interactions and imply either the nanostructuring of the laser-illuminated surface itself, as in cases of direct laser ablation or laser plasma-assisted treatment of semiconductors to form light-absorbing and light-emitting nano-architectures, as well as periodic nanoarrays, or laser-assisted production of nanoclusters and their controlled growth in gaseous or liquid medium to form nanostructured films or colloidal nanoparticles. Nanomaterials synthesized by laser-assisted methods have a variety of unique properties, not reproducible by any other route, and are of importance for photovoltaics, optoelectronics, biological sensing, imaging and therapeutics.

  5. Utilizing Nanofabrication to Construct Strong, Luminescent Materials

    SciTech Connect

    Chen, Wei; Huang, Gang; Lu, Hong B.; McCready, David E.; Joly, Alan G.; Bovin, Jan-Olov

    2006-05-28

    Luminescent materials have been utilized widely in applications from lighting to sensing. The new development of technologies based on luminescence properties requires the materials to have high luminescence efficiency and mechanical strength. In this article, we report the fabrication of luminescent materials possessing high mechanical strength by nanofabrication with polyvinyl alcohol used as a stabilizer or coupling agent. X-ray diffraction and high resolution transmission microscope observations reveal that the nanocomposite sample contains ZnS and ZnO nanoparticles as well as kozoite and sodium nitrate. The mechanical strength and hardness of these nanocomposite materials are higher than polycarbonate and some carbon nanotube reinforced nanocomposites. Strong luminescence is observed in the new nanocomposites and the luminescence intensity does not degrade following up to 30 minutes of X-ray irradiation. Our results indicate that nanofabrication may provide a good method to improve the mechanical strength of luminescent materials for some applications in which high strength luminescent materials are needed.

  6. Nano-fabricated size exclusion chromatograph

    NASA Technical Reports Server (NTRS)

    Svehla, D.; Feldman, S.; Feldman, J.; Grunthaner, F.; Shakkottai, P.; dle Castillo, L.; White, V.

    2002-01-01

    This poster describes the development of a nano-fabricated size exclusion chromatograph (nSEC) based on the principle that molecules traveling through a microcolumn containing nano-fabricated features will have characteristics elution times that directly correlate to molecular weight.

  7. Inclined nanoimprinting lithography-based 3D nanofabrication

    NASA Astrophysics Data System (ADS)

    Liu, Zhan; Bucknall, David G.; Allen, Mark G.

    2011-06-01

    We report a 'top-down' 3D nanofabrication approach combining non-conventional inclined nanoimprint lithography (INIL) with reactive ion etching (RIE), contact molding and 3D metal nanotransfer printing (nTP). This integration of processes enables the production and conformal transfer of 3D polymer nanostructures of varying heights to a variety of other materials including a silicon-based substrate, a silicone stamp and a metal gold (Au) thin film. The process demonstrates the potential of reduced fabrication cost and complexity compared to existing methods. Various 3D nanostructures in technologically useful materials have been fabricated, including symmetric and asymmetric nanolines, nanocircles and nanosquares. Such 3D nanostructures have potential applications such as angle-resolved photonic crystals, plasmonic crystals and biomimicking anisotropic surfaces. This integrated INIL-based strategy shows great promise for 3D nanofabrication in the fields of photonics, plasmonics and surface tribology.

  8. Nanofabrication for Quantum Devices

    NASA Astrophysics Data System (ADS)

    Kern, D. P.; Lee, K. Y.; Rishton, S. A.; Wind, S. J.

    1992-12-01

    Fabrication of structures for investigation of quantum effects frequently involves the use of MBE/CVD type growth processes to achieve control on an atomic scale in vertical direction and a wide range of combinations of lithography and pattern transfer techniques for control in lateral directions. The challenges ahead lie in the degree of lateral control with which the lithography can be performed, i.e. resolution and placement accuracy, but also in the throughput of the lithography equipment once technological applications are considered. Electron beam resolution can certainly extend to the 1 nm regime, in the case of the STM even to 0.1 nm, appropriate resist materials have to be found, however. Parallelism may be introduced into nanolithography through contact printing with X-rays, electron, ion, or X-ray projection, or arrays of miniaturized scanning electron or ion columns. Pattern transfer relies on a broad spectrum of subtractive and additive processes ranging from wet and dry etching to selective growth techniques. Pattern fidelity and damage to the material are the key issues.

  9. Harnessing Disorder in Compression Based Nanofabrication

    NASA Astrophysics Data System (ADS)

    Engel, Clifford John

    The future of nanotechnologies depends on the successful development of versatile, low-cost techniques for patterning micro- and nanoarchitectures. While most approaches to nanofabrication have focused primarily on making periodic structures at ever smaller length scales with an ultimate goal of massively scaling their production, I have focused on introducing control into relatively disordered nanofabrication systems. Well-ordered patterns are increasingly unnecessary for a growing range of applications, from anti-biofouling coatings to light trapping to omniphobic surfaces. The ability to manipulate disorder, at will and over multiple length scales, starting with the nanoscale, can open new prospects for textured substrates and unconventional applications. Taking advantage of previously considered defects; I have been able to develop nanofabrication techniques with potential for massive scalability and the incorporation into a wide range of potential application. This thesis first describes the manipulation of the non-Newtonian properties of liquid Ga and Ga alloys to confine the metal and metal alloys in gratings with sub-wavelength periodicities. Through a solid to liquid phase change, I was able to access the superior plasmonic properties of liquid Ga for the generation of surface plasmon polaritons (SPP). The switching contract between solid and liquid Ga confine in the nanogratings allowed for reversible manipulation of SPP properties through heating and cooling around the relatively low melting temperature of Ga (29.8 °C). The remaining chapters focus on the development and characterization of an all polymer wrinkle material system. Wrinkles, spontaneous disordered features that are produced in response to compressive force, are an ideal for a growing number of applications where fine feature control is no longer the main motivation. However the mechanical limitations of many wrinkle systems have restricted the potential applications of wrinkled surfaces

  10. Model for biological communication in a nanofabricated cell-mimic driven by stochastic resonance

    SciTech Connect

    Karig, David K; Siuti, Piro; Dar, Roy D.; Retterer, Scott T; Doktycz, Mitchel John; Simpson, Michael L

    2011-01-01

    Cells offer natural examples of highly efficient networks of nanomachines. Accordingly, both intracellular and intercellular communication mechanisms in nature are looked to as a source of inspiration and instruction for engineered nanocommunication. Harnessing biological functionality in this manner requires an interdisciplinary approach that integrates systems biology, synthetic biology, and nanofabrication. Recent years have seen the amassing of a tremendous wealth of data from the sequencing of new organisms and from high throughput expression experiments. At the same time, a deeper fundamental understanding of individual cell function has been developed, as exemplified by the growth of fields such as noise biology, which seeks to characterize the role of noise in gene expression. The availability of well characterized biological components coupled with a deeper understanding of cell function has led to efforts to engineer both living cells and to create bio-like functionality in non-living substrates in the field of synthetic biology. Here, we present a model system that exemplifies the synergism between these realms of research. We propose a synthetic gene network for operation in a nanofabricated cell mimic array that propagates a biomolecular signal over long distances using the phenomenon of stochastic resonance. Our system consists of a bacterial quorum sensing signal molecule, a bistable genetic switch triggered by this signal, and an array of nanofabricated cell mimic wells that contain the genetic system. An optimal level of noise in the system helps to propagate a time-varying AHL signal over long distances through the array of mimics. This noise level is determined both by the system volume and by the parameters of the genetic network. Our proposed genetically driven stochastic resonance system serves as a testbed for exploring the potential harnessing of gene expression noise to aid in the transmission of a time-varying molecular signal.

  11. Nanofabrication of Doped, Complex Oxides

    SciTech Connect

    Stein, A.; Waller, G.H.; Abiade, J.T.

    2012-01-01

    Complex oxides have many promising attributes, including wide band gaps for high temperature semiconductors, ion conducting electrolytes in fuel cells, ferroelectricity and ferromagnetism. Bulk and thin film oxides can be readily manufactured and tested however these physically hard and chemically inert materials cannot be nanofabricated by direct application of conventional methods. In order to study these materials at the nanoscale there must first be a simple and effective means to achieve the desired structures. Here we discuss the use of pulsed laser deposition at room temperature onto electron beam lithography defined templates of poly methyl methacrylate photoresist. Following a resist liftoff in organic solvents, a heat treatment was used to crystallize the nanostructures. The morphology of these structures was studied using scanning electron microscopy and atomic force microscopy. Crystallinity and composition as determined by x ray diffraction and photo-electron spectroscopy respectively is reported for thin film analogues of the nanostructured oxide. The oxide studied in this report is Nb doped SrTiO{sub 3}, which has been investigated for use as a high temperature thermoelectric material; however the approach used is not materials-dependent.

  12. Bilayer membrane interactions with nanofabricated scaffolds

    DOE PAGESBeta

    Collier, C. Patrick

    2015-07-29

    Membrane function is facilitated by lateral organization within the lipid bilayer, including phase-separation of lipids into more ordered domains (lipid rafts) and anchoring of the membrane to a cytoskeleton. These features have proven difficult to reproduce in model membrane systems such as black lipid membranes, unilamellar vesicles and supported bilayers. However, advances in micro/nanofabrication have resulted in more realistic synthetic models of membrane-cytoskeleton interactions that can help uncover the design rules responsible for biological membrane formation and organization. This review will focus on describing micro-/nanostructured scaffolds that can emulate the connections of a cellular membrane to an underlying “cytoskeleton”. Thismore » includes molecular-based scaffolds anchored to a solid substrate through surface chemistry, solid-state supports modified by material deposition, lithography and etching, the creation of micro/nanoporous arrays, integration with microfluidics, and droplet-based bilayers at interfaces. Lastly, model systems such as these are increasing our understanding of structure and organization in cell membranes, and how they result in the emergence of functionality at the nanoscale.« less

  13. Bilayer membrane interactions with nanofabricated scaffolds

    SciTech Connect

    Collier, C. Patrick

    2015-07-29

    Membrane function is facilitated by lateral organization within the lipid bilayer, including phase-separation of lipids into more ordered domains (lipid rafts) and anchoring of the membrane to a cytoskeleton. These features have proven difficult to reproduce in model membrane systems such as black lipid membranes, unilamellar vesicles and supported bilayers. However, advances in micro/nanofabrication have resulted in more realistic synthetic models of membrane-cytoskeleton interactions that can help uncover the design rules responsible for biological membrane formation and organization. This review will focus on describing micro-/nanostructured scaffolds that can emulate the connections of a cellular membrane to an underlying “cytoskeleton”. This includes molecular-based scaffolds anchored to a solid substrate through surface chemistry, solid-state supports modified by material deposition, lithography and etching, the creation of micro/nanoporous arrays, integration with microfluidics, and droplet-based bilayers at interfaces. Lastly, model systems such as these are increasing our understanding of structure and organization in cell membranes, and how they result in the emergence of functionality at the nanoscale.

  14. Stress-induced voiding study in integrated circuit interconnects

    NASA Astrophysics Data System (ADS)

    Hou, Yuejin; Tan, Cher Ming

    2008-07-01

    An analytical equation for an ultralarge-scale integration interconnect lifetime due to stress-induced voiding (SIV) is derived from the energy perspective. It is shown that the SIV lifetime is strongly dependent on the passivation quality at the cap layer/interconnect interface, the confinement effect by the surrounding materials to the interconnects, and the available diffusion paths in the interconnects. Contrary to the traditional power-law creep model, we find that the temperature exponent in SIV lifetime formulation is determined by the available diffusion paths for the interconnect atoms and the interconnect geometries. The critical temperature for the SIV is found to be independent of passivation integrity and dielectric confinement effect. Actual stress-free temperature (SFT) during the SIV process is also found to be different from the dielectric/cap layer deposition temperature or the final annealing temperature of the metallization, and it can be evaluated analytically once the activation energy, temperature exponent and critical temperature are determined experimentally. The smaller actual SFT indicates that a strong stress relaxation occurs before the high temperature storage test. Our results show that our SIV lifetime model can be used to predict the SIV lifetime in nano-interconnects.

  15. Programmable solid state atom sources for nanofabrication

    NASA Astrophysics Data System (ADS)

    Han, Han; Imboden, Matthias; Stark, Thomas; Del Corro, Pablo G.; Pardo, Flavio; Bolle, Cristian A.; Lally, Richard W.; Bishop, David J.

    2015-06-01

    In this paper we discuss the development of a MEMS-based solid state atom source that can provide controllable atom deposition ranging over eight orders of magnitude, from ten atoms per square micron up to hundreds of atomic layers, on a target ~1 mm away. Using a micron-scale silicon plate as a thermal evaporation source we demonstrate the deposition of indium, silver, gold, copper, iron, aluminum, lead and tin. Because of their small sizes and rapid thermal response times, pulse width modulation techniques are a powerful way to control the atomic flux. Pulsing the source with precise voltages and timing provides control in terms of when and how many atoms get deposited. By arranging many of these devices into an array, one has a multi-material, programmable solid state evaporation source. These micro atom sources are a complementary technology that can enhance the capability of a variety of nano-fabrication techniques.In this paper we discuss the development of a MEMS-based solid state atom source that can provide controllable atom deposition ranging over eight orders of magnitude, from ten atoms per square micron up to hundreds of atomic layers, on a target ~1 mm away. Using a micron-scale silicon plate as a thermal evaporation source we demonstrate the deposition of indium, silver, gold, copper, iron, aluminum, lead and tin. Because of their small sizes and rapid thermal response times, pulse width modulation techniques are a powerful way to control the atomic flux. Pulsing the source with precise voltages and timing provides control in terms of when and how many atoms get deposited. By arranging many of these devices into an array, one has a multi-material, programmable solid state evaporation source. These micro atom sources are a complementary technology that can enhance the capability of a variety of nano-fabrication techniques. Electronic supplementary information (ESI) available: A document containing further information about device characterization

  16. Energy Harvesting Using PVDF Piezoelectric Nanofabric

    NASA Astrophysics Data System (ADS)

    Shafii, Chakameh Shafii

    Energy harvesting using piezoelectric nanomaterial provides an opportunity for advancement towards self-powered electronics. The fabrication complexities and limited power output of these nano/micro generators have hindered these advancements thus far. This thesis presents a fabrication technique with electrospinning using a grounded cylinder as the collector. This method addresses the difficulties with the production and scalability of the nanogenerators. The non-aligned nanofibers are woven into a textile form onto the cylindrical drum that can be easily removed. The electrical poling and mechanical stretching induced by the electric field and the drum rotation increase the concentration of the piezoelectric beta phase in the PVDF nanofabric. The nanofabric is placed between two layers of polyethylene terephthalate (PET) that have interdigitated electrodes painted on them with silver paint. Applying continuous load onto the flexible PVDF nanofabric at 35Hz produces a peak voltage of 320 mV and maximum power of 2200 pW/(cm2) .

  17. Improved nanofabrication through guided transient liquefaction.

    PubMed

    Chou, Stephen Y; Xia, Qiangfei

    2008-05-01

    A challenge in nanofabrication is to overcome the limitations of various fabrication methods, including defects, line-edge roughness and the minimum size for the feature linewidth. Here we demonstrate a new approach that can remove fabrication defects and improve nanostructures post-fabrication. This method, which we call self-perfection by liquefaction, can significantly reduce the line-edge roughness and, by using a flat plate to guide the process, increase the sidewall slope, flatten the top surface and narrow the width while increasing the height. The technique involves selectively melting nanostructures for a short period of time (hundreds of nanoseconds) while applying a set of boundary conditions to guide the flow of the molten material into the desired geometry before solidification. Using this method we reduced the 3sigma line-edge roughness of 70-nm-wide chromium grating lines from 8.4 nm to less than 1.5 nm, which is well below the 'red-zone limit' of 3 nm discussed in the International Technology Roadmap for Semiconductors. We also reduced the width of a silicon line from 285 nm to 175 nm, while increasing its height from 50 nm to 90 nm. Self-perfection by liquefaction can also be extended to other metals and semiconductors, dielectrics and large-area wafers. PMID:18654527

  18. Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

    PubMed Central

    Du, Jiangang; Blanche, Timothy J.; Harrison, Reid R.; Lester, Henry A.; Masmanidis, Sotiris C.

    2011-01-01

    Extracellular electrode arrays can reveal the neuronal network correlates of behavior with single-cell, single-spike, and sub-millisecond resolution. However, implantable electrodes are inherently invasive, and efforts to scale up the number and density of recording sites must compromise on device size in order to connect the electrodes. Here, we report on silicon-based neural probes employing nanofabricated, high-density electrical leads. Furthermore, we address the challenge of reading out multichannel data with an application-specific integrated circuit (ASIC) performing signal amplification, band-pass filtering, and multiplexing functions. We demonstrate high spatial resolution extracellular measurements with a fully integrated, low noise 64-channel system weighing just 330 mg. The on-chip multiplexers make possible recordings with substantially fewer external wires than the number of input channels. By combining nanofabricated probes with ASICs we have implemented a system for performing large-scale, high-density electrophysiology in small, freely behaving animals that is both minimally invasive and highly scalable. PMID:22022568

  19. Nanofabrication using near-field optical probes

    PubMed Central

    McLeod, Euan; Ozcan, Aydogan

    2012-01-01

    Nanofabrication using near-field optical probes is an established technique for rapid prototyping and automated maskless fabrication of nanostructured devices. In this review, we present the primary types of near-field probes and their physical processing mechanisms. Highlights of recent developments include improved resolution by optimizing the probe shape, incorporation of surface plasmonics in probe design, broader use in biological and magnetic storage applications, and increased throughput using probe arrays as well as high speed writing and patterning. PMID:22713756

  20. Safety Profile of TiO₂-Based Photocatalytic Nanofabrics for Indoor Formaldehyde Degradation.

    PubMed

    Cui, Guixin; Xin, Yan; Jiang, Xin; Dong, Mengqi; Li, Junling; Wang, Peng; Zhai, Shumei; Dong, Yongchun; Jia, Jianbo; Yan, Bing

    2015-01-01

    Anatase TiO₂ nanoparticles (TNPs) are synthesized using the sol-gel method and loaded onto the surface of polyester-cotton (65/35) fabrics. The nanofabrics degrade formaldehyde at an efficiency of 77% in eight hours with visible light irradiation or 97% with UV light. The loaded TNPs display very little release from nanofabrics (~0.0%) during a standard fastness to rubbing test. Assuming TNPs may fall off nanofabrics during their life cycles, we also examine the possible toxicity of TNPs to human cells. We found that up to a concentration of 220 μg/mL, they do not affect viability of human acute monocytic leukemia cell line THP-1 macrophages and human liver and kidney cells. PMID:26610470

  1. Safety Profile of TiO2-Based Photocatalytic Nanofabrics for Indoor Formaldehyde Degradation

    PubMed Central

    Cui, Guixin; Xin, Yan; Jiang, Xin; Dong, Mengqi; Li, Junling; Wang, Peng; Zhai, Shumei; Dong, Yongchun; Jia, Jianbo; Yan, Bing

    2015-01-01

    Anatase TiO2 nanoparticles (TNPs) are synthesized using the sol-gel method and loaded onto the surface of polyester-cotton (65/35) fabrics. The nanofabrics degrade formaldehyde at an efficiency of 77% in eight hours with visible light irradiation or 97% with UV light. The loaded TNPs display very little release from nanofabrics (~0.0%) during a standard fastness to rubbing test. Assuming TNPs may fall off nanofabrics during their life cycles, we also examine the possible toxicity of TNPs to human cells. We found that up to a concentration of 220 μg/mL, they do not affect viability of human acute monocytic leukemia cell line THP-1 macrophages and human liver and kidney cells. PMID:26610470

  2. Nanomaterials and nanofabrication for biomedical applications

    NASA Astrophysics Data System (ADS)

    Cheng, Chao-Min; Chia-Wen Wu, Kevin

    2013-08-01

    Traditional boundaries between materials science and engineering and life sciences are rapidly disintegrating as interdisciplinary research teams develop new materials-science-based tools for exploring fundamental issues in both medicine and biology. With recent technological advances in multiple research fields such as materials science, cell and molecular biology and micro-/nano-technology, much attention is shifting toward evaluating the functional advantages of nanomaterials and nanofabrication, at the cellular and molecular levels, for specific, biomedically relevant applications. The pursuit of this direction enhances the understanding of the mechanisms of, and therapeutic potentials for, some of the most lethal diseases, including cardiovascular diseases, organ fibrosis and cancers. This interdisciplinary approach has generated great interest among researchers working in a wide variety of communities including industry, universities and research laboratories. The purpose of this focus issue in Science and Technology of Advanced Materials is to bridge nanotechnology and biology with medicine, focusing more on the applications of nanomaterials and nanofabrication in biomedically relevant issues. This focus issue, we believe, will provide a more comprehensive understanding of (i) the preparation of nanomaterials and the underlying mechanisms of nanofabrication, and (ii) the linkage of nanomaterials and nanofabrication with biomedical applications. The multidisciplinary focus issue that we have attempted to organize is of interest to various research fields including biomaterials and tissue engineering, bioengineering, nanotechnology and nanomaterials, i.e. chemistry, physics and engineering. Nanomaterials and nanofabrication topics addressed in this focus issue include sensing and diagnosis (e.g. immunosensing and diagnostic devices for diseases), cellular and molecular biology (e.g. probing cellular behaviors and stem cell differentiation) and drug delivery

  3. Green chemistry and nanofabrication in a levitated Leidenfrost drop.

    PubMed

    Abdelaziz, Ramzy; Disci-Zayed, Duygu; Hedayati, Mehdi Keshavarz; Pöhls, Jan-Hendrik; Zillohu, Ahnaf Usman; Erkartal, Burak; Chakravadhanula, Venkata Sai Kiran; Duppel, Viola; Kienle, Lorenz; Elbahri, Mady

    2013-01-01

    Green nanotechnology focuses on the development of new and sustainable methods of creating nanoparticles, their localized assembly and integration into useful systems and devices in a cost-effective, simple and eco-friendly manner. Here we present our experimental findings on the use of the Leidenfrost drop as an overheated and charged green chemical reactor. Employing a droplet of aqueous solution on hot substrates, this method is capable of fabricating nanoparticles, creating nanoscale coatings on complex objects and designing porous metal in suspension and foam form, all in a levitated Leidenfrost drop. As examples of the potential applications of the Leidenfrost drop, fabrication of nanoporous black gold as a plasmonic wideband superabsorber, and synthesis of superhydrophilic and thermal resistive metal-polymer hybrid foams are demonstrated. We believe that the presented nanofabrication method may be a promising strategy towards the sustainable production of functional nanomaterials. PMID:24169567

  4. Green chemistry and nanofabrication in a levitated Leidenfrost drop

    NASA Astrophysics Data System (ADS)

    Abdelaziz, Ramzy; Disci-Zayed, Duygu; Hedayati, Mehdi Keshavarz; Pöhls, Jan-Hendrik; Zillohu, Ahnaf Usman; Erkartal, Burak; Chakravadhanula, Venkata Sai Kiran; Duppel, Viola; Kienle, Lorenz; Elbahri, Mady

    2013-10-01

    Green nanotechnology focuses on the development of new and sustainable methods of creating nanoparticles, their localized assembly and integration into useful systems and devices in a cost-effective, simple and eco-friendly manner. Here we present our experimental findings on the use of the Leidenfrost drop as an overheated and charged green chemical reactor. Employing a droplet of aqueous solution on hot substrates, this method is capable of fabricating nanoparticles, creating nanoscale coatings on complex objects and designing porous metal in suspension and foam form, all in a levitated Leidenfrost drop. As examples of the potential applications of the Leidenfrost drop, fabrication of nanoporous black gold as a plasmonic wideband superabsorber, and synthesis of superhydrophilic and thermal resistive metal-polymer hybrid foams are demonstrated. We believe that the presented nanofabrication method may be a promising strategy towards the sustainable production of functional nanomaterials.

  5. Green chemistry and nanofabrication in a levitated Leidenfrost drop

    PubMed Central

    Abdelaziz, Ramzy; Disci-Zayed, Duygu; Hedayati, Mehdi Keshavarz; Pöhls, Jan-Hendrik; Zillohu, Ahnaf Usman; Erkartal, Burak; Chakravadhanula, Venkata Sai Kiran; Duppel, Viola; Kienle, Lorenz; Elbahri, Mady

    2013-01-01

    Green nanotechnology focuses on the development of new and sustainable methods of creating nanoparticles, their localized assembly and integration into useful systems and devices in a cost-effective, simple and eco-friendly manner. Here we present our experimental findings on the use of the Leidenfrost drop as an overheated and charged green chemical reactor. Employing a droplet of aqueous solution on hot substrates, this method is capable of fabricating nanoparticles, creating nanoscale coatings on complex objects and designing porous metal in suspension and foam form, all in a levitated Leidenfrost drop. As examples of the potential applications of the Leidenfrost drop, fabrication of nanoporous black gold as a plasmonic wideband superabsorber, and synthesis of superhydrophilic and thermal resistive metal–polymer hybrid foams are demonstrated. We believe that the presented nanofabrication method may be a promising strategy towards the sustainable production of functional nanomaterials. PMID:24169567

  6. Femtosecond laser three-dimensional micro- and nanofabrication

    SciTech Connect

    Sugioka, Koji; Cheng, Ya

    2014-12-15

    The rapid development of the femtosecond laser has revolutionized materials processing due to its unique characteristics of ultrashort pulse width and extremely high peak intensity. The short pulse width suppresses the formation of a heat-affected zone, which is vital for ultrahigh precision fabrication, whereas the high peak intensity allows nonlinear interactions such as multiphoton absorption and tunneling ionization to be induced in transparent materials, which provides versatility in terms of the materials that can be processed. More interestingly, irradiation with tightly focused femtosecond laser pulses inside transparent materials makes three-dimensional (3D) micro- and nanofabrication available due to efficient confinement of the nonlinear interactions within the focal volume. Additive manufacturing (stereolithography) based on multiphoton absorption (two-photon polymerization) enables the fabrication of 3D polymer micro- and nanostructures for photonic devices, micro- and nanomachines, and microfluidic devices, and has applications for biomedical and tissue engineering. Subtractive manufacturing based on internal modification and fabrication can realize the direct fabrication of 3D microfluidics, micromechanics, microelectronics, and photonic microcomponents in glass. These microcomponents can be easily integrated in a single glass microchip by a simple procedure using a femtosecond laser to realize more functional microdevices, such as optofluidics and integrated photonic microdevices. The highly localized multiphoton absorption of a tightly focused femtosecond laser in glass can also induce strong absorption only at the interface of two closely stacked glass substrates. Consequently, glass bonding can be performed based on fusion welding with femtosecond laser irradiation, which provides the potential for applications in electronics, optics, microelectromechanical systems, medical devices, microfluidic devices, and small satellites. This review paper

  7. Femtosecond laser three-dimensional micro- and nanofabrication

    NASA Astrophysics Data System (ADS)

    Sugioka, Koji; Cheng, Ya

    2014-12-01

    The rapid development of the femtosecond laser has revolutionized materials processing due to its unique characteristics of ultrashort pulse width and extremely high peak intensity. The short pulse width suppresses the formation of a heat-affected zone, which is vital for ultrahigh precision fabrication, whereas the high peak intensity allows nonlinear interactions such as multiphoton absorption and tunneling ionization to be induced in transparent materials, which provides versatility in terms of the materials that can be processed. More interestingly, irradiation with tightly focused femtosecond laser pulses inside transparent materials makes three-dimensional (3D) micro- and nanofabrication available due to efficient confinement of the nonlinear interactions within the focal volume. Additive manufacturing (stereolithography) based on multiphoton absorption (two-photon polymerization) enables the fabrication of 3D polymer micro- and nanostructures for photonic devices, micro- and nanomachines, and microfluidic devices, and has applications for biomedical and tissue engineering. Subtractive manufacturing based on internal modification and fabrication can realize the direct fabrication of 3D microfluidics, micromechanics, microelectronics, and photonic microcomponents in glass. These microcomponents can be easily integrated in a single glass microchip by a simple procedure using a femtosecond laser to realize more functional microdevices, such as optofluidics and integrated photonic microdevices. The highly localized multiphoton absorption of a tightly focused femtosecond laser in glass can also induce strong absorption only at the interface of two closely stacked glass substrates. Consequently, glass bonding can be performed based on fusion welding with femtosecond laser irradiation, which provides the potential for applications in electronics, optics, microelectromechanical systems, medical devices, microfluidic devices, and small satellites. This review paper

  8. Silicon Micro- and Nanofabrication for Medicine

    PubMed Central

    Fine, Daniel; Goodall, Randy; Bansal, Shyam S.; Chiappini, Ciro; Hosali, Sharath; van de Ven, Anne L.; Srinivasan, Srimeenkashi; Liu, Xuewu; Godin, Biana; Brousseau, Louis; Yazdi, Iman K.; Fernandez-Moure, Joseph; Tasciotti, Ennio; Wu, Hung-Jen; Hu, Ye; Klemm, Steve; Ferrari, Mauro

    2013-01-01

    This manuscript constitutes a review of several innovative biomedical technologies fabricated using the precision and accuracy of silicon micro- and nanofabrication. The technologies to be reviewed are subcutaneous nanochannel drug delivery implants for the continuous tunable zero-order release of therapeutics, multi-stage logic embedded vectors for the targeted systemic distribution of both therapeutic and imaging contrast agents, silicon and porous silicon nanowires for investigating cellular interactions and processes as well as for molecular and drug delivery applications, porous silicon (pSi) as inclusions into biocomposites for tissue engineering, especially as it applies to bone repair and regrowth, and porous silica chips for proteomic profiling. In the case of the biocomposites, the specifically designed pSi inclusions not only add to the structural robustness, but can also promote tissue and bone regrowth, fight infection, and reduce pain by releasing stimulating factors and other therapeutic agents stored within their porous network. The common material thread throughout all of these constructs, silicon and its associated dielectrics (silicon dioxide, silicon nitride, etc.), can be precisely and accurately machined using the same scalable micro- and nanofabrication protocols that are ubiquitous within the semiconductor industry. These techniques lend themselves to the high throughput production of exquisitely defined and monodispersed nanoscale features that should eliminate architectural randomness as a source of experimental variation thereby potentially leading to more rapid clinical translation. PMID:23584841

  9. Tip Based Nanofabrication Using Multi-mode Scanning Probe Microscopy

    NASA Astrophysics Data System (ADS)

    Hu, Weihua

    -mode SPM nanofabrication method, we characterized SPM local oxidation with conductive AFM probes. It was found out that STM and AFM mode local oxidation can be thought of as similar processes but working at different operating points in terms of normal force. Finally we investigated the current transport mechanism of Ti-TiO x-Ti junction by taking current-voltage (I-V) measurement at different temperatures ranging from 100 K to 300 K. The I-V data of the Ti-TiO x-Ti junctions we fabricated could not be explained by Thermionic emission or electron tunneling model, which was quite different from the results published in literature.

  10. The Stanford Nanofabrication Facility and the National Nanofabrication Users' Network: the ultimate sandbox for bioMEMS and bioengineering R&D

    NASA Astrophysics Data System (ADS)

    Tang, Mary X.

    2003-01-01

    As cutting-edge research becomes more multidisciplinary, it becomes increasingly difficult to find experimental and laboratory resources that can support such broadly defined research. The five, founding-member university facilities of the Nanofabrication Users' Network (NNUN) have been providing such broad-based resources for nine years. The goal of the NNUN is not only to develop micro- and nanotechnology fabrication resources and expertise across a broad range of disciplines, but also to encourage researchers from industry as well as academia outside the network to make use of our facilities. All NNUN sites are shared-equipment, open-use laboratories featuring a broad range of micro- and nanofabrication equipment. The NNUN is comprised of two main "hub" facilities at Stanford and Cornell Universities, and three "satellite" facilities at the University of California, Santa Barbara, Penn State University, and Howard University. Based on the academic traditions of openness and sharing, these facilities comprise a vibrant, dynamic community of researchers. Our lab members come from a wide variety of disciplines, with research in areas of optics, MEMS, biology, and chemistry, as well as process characterization and fabrication of more traditional electronics devices. We are especially committed to supporting use of micro- and nanofabrication technologies in non-traditional research applications. The NNUN is supported by the National Science Foundation under cooperative agreements ECS-9731293 and ECS-9731294.

  11. Model for biological communication in a nanofabricated cell-mimic driven by stochastic resonance

    PubMed Central

    Karig, David K.; Siuti, Piro; Dar, Roy D.; Retterer, Scott. T.; Doktycz, Mitchel J.; Simpson, Michael L.

    2011-01-01

    Cells offer natural examples of highly efficient networks of nanomachines. Accordingly, both intracellular and intercellular communication mechanisms in nature are looked to as a source of inspiration and instruction for engineered nanocommunication. Harnessing biological functionality in this manner requires an interdisciplinary approach that integrates systems biology, synthetic biology, and nanofabrication. Here, we present a model system that exemplifies the synergism between these realms of research. We propose a synthetic gene network for operation in a nanofabricated cell mimic array that propagates a biomolecular signal over long distances using the phenomenon of stochastic resonance. Our system consists of a bacterial quorum sensing signal molecule, a bistable genetic switch triggered by this signal, and an array of nanofabricated cell mimic wells that contain the genetic system. An optimal level of noise in the system helps to propagate a time-varying AHL signal over long distances through the array of mimics. This noise level is determined both by the system volume and by the parameters of the genetic network. Our proposed genetically driven stochastic resonance system serves as a testbed for exploring the potential harnessing of gene expression noise to aid in the transmission of a time-varying molecular signal. PMID:21731597

  12. Micro- and nanofabrication methods in nanotechnological medical and pharmaceutical devices

    PubMed Central

    Betancourt, Tania; Brannon-Peppas, Lisa

    2006-01-01

    Micro- and nanofabrication techniques have revolutionized the pharmaceutical and medical fields as they offer the possibility for highly reproducible mass-fabrication of systems with complex geometries and functionalities, including novel drug delivery systems and bionsensors. The principal micro- and nanofabrication techniques are described, including photolithography, soft lithography, film deposition, etching, bonding, molecular self assembly, electrically induced nanopatterning, rapid prototyping, and electron, X-ray, colloidal monolayer, and focused ion beam lithography. Application of these techniques for the fabrication of drug delivery and biosensing systems including injectable, implantable, transdermal, and mucoadhesive devices is described. PMID:17722281

  13. Nanofabrication in the Magnetic Recording Industry: Past, Present and Future

    NASA Astrophysics Data System (ADS)

    Ruiz, Ricardo

    2015-03-01

    The magnetic recording industry stands out as an example of multidisciplinary nanotechnology that keeps pushing the envelope in terms of controlling matter and events at the nanometer length scale. From magnetic media composed of sub-10 nm grains, to overcoat protecting layers that are only 2-3 nm thick, to read sensors that are ~ 30 nm wide, to recording heads that fly at ~ 5 nm heights with speeds up to 100 mi/hr, nanotechnology and nanofabrication have been inseparable to the success and extendibility of hard disk drives. Looking into the future, as the demand for data storage continues to increase in a data-centric, cloud-connected environment, future magnetic recording will need to scale accordingly to accommodate ever increasing demands for areal density gains. Future storage technologies such as heat assisted magnetic recording that employs plasmonic antennas or magnetic bit patterned media that requires self-assembly of block copolymers, also stake their success in the advances of nanoscience. I will review research opportunities in this industry with a personal perspective of a decade's worth in self-assembly for lithographic applications.

  14. Nanofabrication for the Analysis and Manipulation of Membranes

    PubMed Central

    Kelly, Christopher V.; Craighead, Harold G.

    2015-01-01

    Recent advancements and applications of nanofabrication have enabled the characterization and control of biological membranes at submicron scales. This review focuses on the application of nanofabrication towards the nanoscale observing, patterning, sorting, and concentrating membrane components. Membranes on living cells are a necessary component of many fundamental cellular processes that naturally incorporate nanoscale rearrangement of the membrane lipids and proteins. Nanofabrication has advanced these understandings, for example, by providing 30 nm resolution of membrane proteins with metal-enhanced fluorescence at the tip of a scanning probe on fixed cells. Naturally diffusing single molecules at high concentrations on live cells have been observed at 60 nm resolution by confining the fluorescence excitation light through nanoscale metallic apertures. The lateral reorganization on the plasma membrane during membrane-mediated signaling processes has been examined in response to nanoscale variations in the patterning and mobility of the signal-triggering molecules. Further, membrane components have been separated, concentrated, and extracted through on-chip electrophoretic and microfluidic methods. Nanofabrication provides numerous methods for examining and manipulating membranes for both greater understandings of membrane processes as well as for the application of membranes to other biophysical methods. PMID:22143598

  15. Perylene Diimide Based ``Nanofabric'' Thin Films for Organic Photovoltaic Cells

    NASA Astrophysics Data System (ADS)

    Carter, Austin; Park, June Hyoung; Min, Yong; Epstein, Arthur

    2011-03-01

    We report progress in using a perylene diimide (PDI) nanofabric as an effective electron accepting nanostructure for organic photovoltaics (OPV). A key challenge in OPV continues to be the recovery of electrons after charge separation due to the relatively poor mobility of C60 and related materials. A series of PDI compounds and complexes have been synthesized and used to fabricate nanofibers and thin films using solution and vacuum deposition techniques. Overlaping PDI-based nanofibers form a fast electron-transporting ``nanofabric'' that has been characterized (AFM, PL, UV-vis, etc.) and can be blended with electron donating materials. A solution-processible OPV configuration containing a nanofabric heterojunction (FHJ) of poly(3-hexylthiophene) and the PDI nanofabric was investigated. We observed a significant improvement in power-conversion efficiency due in part to expansion of the interfacial area and the presence of high mobility electron pathways to the LiF/Al electrode. This work is supported by the Wright Center for Photovoltaic Innovation and Commercialization, the Institute for Materials Research and the Center for Affordable Nanoengineering of Polymeric Biomedical Devices.

  16. Cryogenic Nano-Fabrication using the Fab on a Chip approach

    NASA Astrophysics Data System (ADS)

    Imboden, Matthias; Han, Han; Stark, Thomas; Lowell, Evan; Chang, Jackson; Pardo, Flavio; Bolle, Cristian; Del Corro, Pablo; Bishop, David

    2014-03-01

    The Fab on a Chip approach is a novel fabrication technique that leverages the control and stability of MEMS machines to fabricate structures on the nano-scale. This contrasts to standard deep-UV and e-beam lithography methods typically used today. We present how a fully functional nano-fabrication system can be operated in a cryostat to enable novel physics experiments. To this end MEMS based machines are built that mimic typical macroscopic tools found in a modern nano-fabrication facility. We demonstrate functioning film thickness monitors, heaters, shutters and atom flux sources that can all be integrated on a single silicon chip. At the heart of the fab is a dynamic shutter-aperture system that functions as a programmable stencil which guides atoms to specific locations at precise times. It is argued that this method has the potential to obtain single atom control of the deposited materials. The low power and small footprint enables the setup to function in a cryogenic environment. We demonstrate basic functionality of the elements at liquid helium temperatures. The advantage of resist free lithography and the deposition being the final fabrication step is the ability to pattern materials incompatible with standard techniques. Furthermore, the ultra-clean environment is suited for high purity fabrication of structures made of exotic materials such as lithium, with the intent to enable novel electron transport experiments.

  17. Nanofabrication on unconventional substrates using transferred hard masks

    DOE PAGESBeta

    Li, Luozhou; Bayn, Igal; Lu, Ming; Nam, Chang -Yong; Schroder, Tim; Stein, Aaron; Harris, Nicholas C.; Englund, Dirk

    2015-01-15

    Here, a major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silicon membrane hard masks, patterned using standard lithography and mature silicon processing technology. These masks, transferred precisely onto targeted regions, can be in the millimetre scale. They allow for fabrication on a wide range of substrates, including rough, soft, and non-conductive materials, enabling feature linewidths down to 10 nm. Plasma etching, lift-off, and ion implantationmore » are realized without the need for scanning electron/ion beam processing, UV exposure, or wet etching on target substrates.« less

  18. Nanofabrication on unconventional substrates using transferred hard masks

    NASA Astrophysics Data System (ADS)

    Li, Luozhou; Bayn, Igal; Lu, Ming; Nam, Chang-Yong; Schröder, Tim; Stein, Aaron; Harris, Nicholas C.; Englund, Dirk

    2015-01-01

    A major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silicon membrane hard masks, patterned using standard lithography and mature silicon processing technology. These masks, transferred precisely onto targeted regions, can be in the millimetre scale. They allow for fabrication on a wide range of substrates, including rough, soft, and non-conductive materials, enabling feature linewidths down to 10 nm. Plasma etching, lift-off, and ion implantation are realized without the need for scanning electron/ion beam processing, UV exposure, or wet etching on target substrates.

  19. Nanofabrication on unconventional substrates using transferred hard masks

    SciTech Connect

    Li, Luozhou; Bayn, Igal; Lu, Ming; Nam, Chang -Yong; Schroder, Tim; Stein, Aaron; Harris, Nicholas C.; Englund, Dirk

    2015-01-15

    Here, a major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silicon membrane hard masks, patterned using standard lithography and mature silicon processing technology. These masks, transferred precisely onto targeted regions, can be in the millimetre scale. They allow for fabrication on a wide range of substrates, including rough, soft, and non-conductive materials, enabling feature linewidths down to 10 nm. Plasma etching, lift-off, and ion implantation are realized without the need for scanning electron/ion beam processing, UV exposure, or wet etching on target substrates.

  20. Nanofabrication on unconventional substrates using transferred hard masks

    PubMed Central

    Li, Luozhou; Bayn, Igal; Lu, Ming; Nam, Chang-Yong; Schröder, Tim; Stein, Aaron; Harris, Nicholas C.; Englund, Dirk

    2015-01-01

    A major challenge in nanofabrication is to pattern unconventional substrates that cannot be processed for a variety of reasons, such as incompatibility with spin coating, electron beam lithography, optical lithography, or wet chemical steps. Here, we present a versatile nanofabrication method based on re-usable silicon membrane hard masks, patterned using standard lithography and mature silicon processing technology. These masks, transferred precisely onto targeted regions, can be in the millimetre scale. They allow for fabrication on a wide range of substrates, including rough, soft, and non-conductive materials, enabling feature linewidths down to 10 nm. Plasma etching, lift-off, and ion implantation are realized without the need for scanning electron/ion beam processing, UV exposure, or wet etching on target substrates. PMID:25588550

  1. Micro- and nano-fabricated implantable drug-delivery systems

    PubMed Central

    Meng, Ellis; Hoang, Tuan

    2013-01-01

    Implantable drug-delivery systems provide new means for achieving therapeutic drug concentrations over entire treatment durations in order to optimize drug action. This article focuses on new drug administration modalities achieved using implantable drug-delivery systems that are enabled by micro- and nano-fabrication technologies, and microfluidics. Recent advances in drug administration technologies are discussed and remaining challenges are highlighted. PMID:23323562

  2. Polarization Control via He-Ion Beam Induced Nanofabrication in Layered Ferroelectric Semiconductors.

    PubMed

    Belianinov, Alex; Iberi, Vighter; Tselev, Alexander; Susner, Michael A; McGuire, Michael A; Joy, David; Jesse, Stephen; Rondinone, Adam J; Kalinin, Sergei V; Ovchinnikova, Olga S

    2016-03-23

    Rapid advances in nanoscience rely on continuous improvements of material manipulation at near-atomic scales. Currently, the workhorse of nanofabrication is resist-based lithography and its various derivatives. However, the use of local electron, ion, and physical probe methods is expanding, driven largely by the need for fabrication without the multistep preparation processes that can result in contamination from resists and solvents. Furthermore, probe-based methods extend beyond nanofabrication to nanomanipulation and to imaging which are all vital for a rapid transition to the prototyping and testing of devices. In this work we study helium ion interactions with the surface of bulk copper indium thiophosphate CuM(III)P2X6 (M = Cr, In; X= S, Se), a novel layered 2D material, with a Helium Ion Microscope (HIM). Using this technique, we are able to control ferrielectric domains and grow conical nanostructures with enhanced conductivity whose material volumes scale with the beam dosage. Compared to the copper indium thiophosphate (CITP) from which they grow, the nanostructures are oxygen rich, sulfur poor, and with virtually unchanged copper concentration as confirmed by energy-dispersive X-ray spectroscopy (EDX). Scanning electron microscopy (SEM) imaging contrast as well as scanning microwave microscopy (SMM) measurements suggest enhanced conductivity in the formed particles, whereas atomic force microscopy (AFM) measurements indicate that the produced structures have lower dissipation and are softer as compared to the CITP. PMID:26918591

  3. One-step substrate nanofabrication and patterning of nanoparticles by lithographically controlled etching

    NASA Astrophysics Data System (ADS)

    Bianchi, M.; Limones Herrero, D.; Valle, F.; Greco, P.; Ingo, G. M.; Kaciulis, S.; Biscarini, F.; Cavallini, M.

    2011-09-01

    We propose an integrated top-down and bottom-up approach to single-step nanofabrication of complex nanostructures made of different materials. The process, termed lithographically controlled etching (LCE), starts with a drop of an etching solution cast on the surface to be patterned. By placing a polymeric mold on the substrate, the stamp protrusions come into contact with the surface, thus protecting it, whereas the surface beneath the mold recesses is exposed to a thin layer of etching solution, allowing the surface to be etched. By dispersing nanoparticles into the etching solution, these can be deposited and self-organize in the recesses on the substrate as these are excavated. We demonstrate here the fabrication of complex structures and nanowires 30 nm wide. Moreover, by exploiting capillary forces, it is possible to deposit nanoparticles at precise positions with respect to optically addressable microstructures, thus realizing a multiscale functional pattern.

  4. Maskless micro/nanofabrication on GaAs surface by friction-induced selective etching

    NASA Astrophysics Data System (ADS)

    Tang, Peng; Yu, Bingjun; Guo, Jian; Song, Chenfei; Qian, Linmao

    2014-02-01

    In the present study, a friction-induced selective etching method was developed to produce nanostructures on GaAs surface. Without any resist mask, the nanofabrication can be achieved by scratching and post-etching in sulfuric acid solution. The effects of the applied normal load and etching period on the formation of the nanostructure were studied. Results showed that the height of the nanostructure increased with the normal load or the etching period. XPS and Raman detection demonstrated that residual compressive stress and lattice densification were probably the main reason for selective etching, which eventually led to the protrusive nanostructures from the scratched area on the GaAs surface. Through a homemade multi-probe instrument, the capability of this fabrication method was demonstrated by producing various nanostructures on the GaAs surface, such as linear array, intersecting parallel, surface mesas, and special letters. In summary, the proposed method provided a straightforward and more maneuverable micro/nanofabrication method on the GaAs surface.

  5. Maskless micro/nanofabrication on GaAs surface by friction-induced selective etching.

    PubMed

    Tang, Peng; Yu, Bingjun; Guo, Jian; Song, Chenfei; Qian, Linmao

    2014-01-01

    In the present study, a friction-induced selective etching method was developed to produce nanostructures on GaAs surface. Without any resist mask, the nanofabrication can be achieved by scratching and post-etching in sulfuric acid solution. The effects of the applied normal load and etching period on the formation of the nanostructure were studied. Results showed that the height of the nanostructure increased with the normal load or the etching period. XPS and Raman detection demonstrated that residual compressive stress and lattice densification were probably the main reason for selective etching, which eventually led to the protrusive nanostructures from the scratched area on the GaAs surface. Through a homemade multi-probe instrument, the capability of this fabrication method was demonstrated by producing various nanostructures on the GaAs surface, such as linear array, intersecting parallel, surface mesas, and special letters. In summary, the proposed method provided a straightforward and more maneuverable micro/nanofabrication method on the GaAs surface. PMID:24495647

  6. Polarization Control via He-Ion Beam Induced Nanofabrication in Layered Ferroelectric Semiconductors

    DOE PAGESBeta

    Belianinov, Alex; Iberi, Vighter; Tselev, Alexander; Susner, Michael A.; McGuire, Michael A.; Joy, David; Jesse, Stephen; Rondinone, Adam J.; Kalinin, Sergei V.; Ovchinnikova, Olga S.

    2016-02-23

    Rapid advanced in nanoscience rely on continuous improvements of matter manipulation at near atomic scales. Currently, well characterized, robust, resist-based lithography carries the brunt of the nanofabrication process. However, use of local electron, ion and physical probe methods is also expanding, driven largely by their ability to fabricate without the multi-step preparation processes that can result in contamination from resists and solvents. Furthermore, probe based methods extend beyond nanofabrication to nanomanipulation and imaging, vital ingredients to rapid transition to prototyping and testing of layered 2D heterostructured devices. In this work we demonstrate that helium ion interaction, in a Helium Ionmore » Microscope (HIM), with the surface of bulk copper indium thiophosphate CuMIIIP2X6 (M = Cr, In; X= S, Se), (CITP) results in the control of ferroelectric domains, and growth of cylindrical nanostructures with enhanced conductivity; with material volumes scaling with the dosage of the beam. The nanostructures are oxygen rich, sulfur poor, and with the copper concentration virtually unchanged as confirmed by Energy Dispersive X-ray (EDX). Scanning Electron Microscopy (SEM) imaging contrast as well as Scanning Microwave Microscopy (SMM) measurements suggest enhanced conductivity in the formed particle, whereas Atomic Force Microscopy (AFM) measurements indicate that the produced structures have lower dissipation and a lower Young s modulus.« less

  7. Maskless micro/nanofabrication on GaAs surface by friction-induced selective etching

    PubMed Central

    2014-01-01

    In the present study, a friction-induced selective etching method was developed to produce nanostructures on GaAs surface. Without any resist mask, the nanofabrication can be achieved by scratching and post-etching in sulfuric acid solution. The effects of the applied normal load and etching period on the formation of the nanostructure were studied. Results showed that the height of the nanostructure increased with the normal load or the etching period. XPS and Raman detection demonstrated that residual compressive stress and lattice densification were probably the main reason for selective etching, which eventually led to the protrusive nanostructures from the scratched area on the GaAs surface. Through a homemade multi-probe instrument, the capability of this fabrication method was demonstrated by producing various nanostructures on the GaAs surface, such as linear array, intersecting parallel, surface mesas, and special letters. In summary, the proposed method provided a straightforward and more maneuverable micro/nanofabrication method on the GaAs surface. PMID:24495647

  8. Friction-induced nanofabrication method to produce protrusive nanostructures on quartz

    NASA Astrophysics Data System (ADS)

    Song, Chenfei; Li, Xiaoying; Yu, Bingjun; Dong, Hanshan; Qian, Linmao; Zhou, Zhongrong

    2011-12-01

    In this paper, a new friction-induced nanofabrication method is presented to fabricate protrusive nanostructures on quartz surfaces through scratching a diamond tip under given normal loads. The nanostructures, such as nanodots, nanolines, surface mesas and nanowords, can be produced on the target surface by programming the tip traces according to the demanded patterns. The height of these nanostructures increases with the increase of the number of scratching cycles or the normal load. Transmission electron microscope observations indicated that the lattice distortion and dislocations induced by the mechanical interaction may have played a dominating role in the formation of the protrusive nanostructures on quartz surfaces. Further analysis reveals that during scratching, a contact pressure ranged from 0.4 P y to P y ( P y is the critical yield pressure of quartz) is apt to produce protuberant nanostructures on quartz under the given experimental conditions. Finally, it is of great interest to find that the protrusive nanostructures can be selectively dissolved in 20% KOH solution. Since the nanowords can be easily 'written' by friction-induced fabrication and 'erased' through selective etching on a quartz surface, this friction-induced method opens up new opportunities for future nanofabrication.

  9. Synthesis and characterization of high-throughput nanofabricated poly(4-hydroxy styrene) membranes for in vitro models of barrier tissue.

    PubMed

    Shayan, Gilda; Felix, Nelson; Cho, Youngjin; Chatzichristidi, Margarita; Shuler, Michael L; Ober, Christopher K; Lee, Kelvin H

    2012-09-01

    Commercially available permeable supports with microporous membranes have led to significant improvements in the culture of polarized cells because they permit them to feed basolaterally and thus carry out metabolism in a more in vivo-like setting. The porous nature of these membranes enables permeability measurements of drugs or biomolecules across the cellular barrier. However, current porous membranes have a high flow resistance due to great thickness (20-40 μm), low porosity, and a wide pore size distribution with tortuous diffusion paths, which make them low-throughput for permeability studies. Here we describe an alternate platform that is more flexible, allows for more control over physical parameters of the membranes, and is high-throughput. This study reports on the synthesis, nanofabrication, and surface characterization of a 3-μm-thick transparent membrane based on poly(4-hydroxy styrene) (PHOST). The membranes are nanofabricated using electron beam lithography and deep ion plasma etching to achieve an organized array of straight pores from 50 to 800 nm in diameter, with at least 23 times less flow resistance. It also shows for the first time the potential utility of PHOST as a cell culture substrate without cytotoxicity, and suitability for nanofabrication processes due to temperature stability. PMID:22435738

  10. Nanofabrication advances for high efficiency critical-angle transmission gratings

    NASA Astrophysics Data System (ADS)

    Bruccoleri, Alexander R.; Guan, Dong; Heilmann, Ralf K.; Vargo, Steve; DiPiazza, Frank; Schattenburg, Mark L.

    2013-09-01

    We report several break-through nanofabrication developments enabling high efficiency and high resolving power spectrometers in the soft x-ray band. The device is the critical-angle transmission (CAT) grating, which combines the low mass and relaxed alignment tolerances of a transmission grating with the high broad-band efficiency and high diffraction orders of a blazed reflection grating. Past work successfully demonstrated the CAT grating concept; however, the open-area fraction was often less than 20% whilst more than 50% is desired. This presents numerous nanofabrication challenges including a requirement for a freestanding silicon membrane of ultra high-aspect ratio bars at a period of 200 nanometers with minimal cross support blockage. Furthermore, the sidewalls must be smooth to a few nanometers to efficiently reflect soft x-rays. We have developed a complete nanofabrication process for creating freestanding CAT gratings via plasma-etching silicon wafers with a buried layer of SiO2. This removable buried layer enables combining a record-performance plasma etch for the CAT grating with a millimeter-scale honeycomb structural support to create a large-area freestanding membrane. We have also developed a process for polishing sidewalls of plasma-etched ultra-high aspect ratio nanoscale silicon structures via potassium hydroxide (KOH). This process utilizes the anisotropic etch nature of single crystal silicon in KOH. We developed a novel alignment technique to align the CAT grating bars to the {111} planes of silicon within 0.2 degrees, which enables KOH to etch away sidewall roughness without destroying the structure, since the {111} planes etch approximately 100 times slower than the non-{111} planes. Preliminary results of a combined freestanding grating with polishing are presented to enable efficient diffraction of soft x-rays.

  11. Tip-based nanofabrication: an approach to true nanotechnology

    NASA Astrophysics Data System (ADS)

    Schofield, Adam R.; Bloschock, Kristen P.; Kenny, Thomas W.

    2010-03-01

    In order to unlock the true potential of nanotechnology, the development of controlled nanomanufacturing techniques for individual structures is critical. While the capability to grow, deposit, and manipulate nanostructures currently exists, the ability to reliably fabricate these devices with controlled differences in size, shape, and orientation at various substrate positions does not exist. To bridge this gap, the Defense Advanced Research Projects Agency (DARPA) launched the Tip-Based Nanofabrication (TBN) research program with the intent of achieving controlled nanomanufacturing of nanowires, nanotubes and quantum dots using functionalized AFM cantilevers and tips. This work describes the background, goals, and current approaches being explored during the multi-year TBN program.

  12. Applications of sample nanofabrication in diamond-anvil cell experiments

    NASA Astrophysics Data System (ADS)

    Pigott, J. S.; Fischer, R. A.; Hrubiak, R.; Scott, H. P.; Panero, W. R.

    2015-12-01

    We use electron gun evaporation, sputter deposition, and photolithography to fabricate samples for laser-heated diamond anvil cell experiments. With complimentary thermal modeling, the sample geometry can be optimized and tailored to the experimental application. Here we highlight equation of state studies using nanofabricated double-hot plate samples. The homogeneous samples produced by our methods lead to exceptionally even heating both spatially and temporally that produced high-quality equations of state for nickel and stishovite. The Fe and Pt mutual equations of state may be well characterized and we show recent progress in fabricating samples consisting of a layered stack of Pt/SiO2/Fe/SiO2 in which the SiO2 serves to prevent the alloying of Fe and Pt. Finally, by exploiting state-of-the art nanofabrication techniques, we explore a wider range of the potential applications of such samples including high-pressure, high-temperature diffusion, melting, and thermal conductivity. Using the TempDAC code, we investigate the ideal sizes and ratios of the sample, heating laser diameter, and x-ray spot size while quantifying the effect of x-ray misalignment.

  13. Nano-fabricated plasmonic optical transformer

    DOEpatents

    Choo, Hyuck; Cabrini, Stefano; Schuck, P. James; Liang, Xiaogan; Yablonovitch, Eli

    2015-06-09

    The present invention provides a plasmonic optical transformer to produce a highly focuses optical beam spot, where the transformer includes a first metal layer, a dielectric layer formed on the first metal layer, and a second metal layer formed on the dielectric layer, where the first metal layer, the dielectric layer, and the second layer are patterned to a shape including a first section having a first cross section, a second section following the first section having a cross-section tapering from the first section to a smaller cross-section, and a third section following the second section having a cross-section matching the tapered smaller cross-section of the second section.

  14. Tip-based nanofabrication: an approach to true nanotechnology

    NASA Astrophysics Data System (ADS)

    Bloschock, Kristen P.; Schofield, Adam R.; Kenny, Thomas W.

    2011-06-01

    True nanotechnology, defined as the ability to reliably and repeatably fabricate nanostructures with controlled differences in size, shape, and orientation at precise substrate locations, currently does not exist. There are many examples demonstrating the capability to grow, deposit, and manipulate nanometer-sized features, but typically these techniques do not allow for controllable manufacturing of individual structures. To bridge this gap and to unlock the true potential of nanotechnology for defense sensing applications, the Defense Advanced Research Projects Agency (DARPA) launched the Tip-Based Nanofabrication (TBN) research program with the intent of achieving controlled manufacturing of nanostructures using functionalized AFM cantilevers and tips. This work describes the background, goals, and recent advances achieved during the multi-year TBN program.

  15. Chip-Scale Nanofabrication of Single Spins and Spin Arrays in Diamond

    SciTech Connect

    Toyli, David M.; Weis, Christoph D.; Fuchs, D.; Schenkel, Thomas; Awschalom, David D.

    2010-07-02

    We demonstrate a technique to nanofabricate nitrogen vacancy (NV) centers in diamond based on broad-beam nitrogen implantation through apertures in electron beam lithography resist. This method enables high-throughput nanofabrication of single NV centers on sub-100-nm length scales. Secondary ion mass spectroscopy measurements facilitate depth profiling of the implanted nitrogen to provide three-dimensional characterization of the NV center spatial distribution. Measurements of NV center coherence with on-chip coplanar waveguides suggest a pathway for incorporating this scalable nanofabrication technique in future quantum applications.

  16. Analysis of structural changes in active site of luciferase adsorbed on nanofabricated hydrophilic Si surface by molecular-dynamics simulations

    SciTech Connect

    Nishiyama, Katsuhiko; Hoshino, Tadatsugu

    2007-05-21

    Interactions between luciferase and a nanofabricated hydrophilic Si surface were explored by molecular-dynamics simulations. The structural changes in the active-site residues, the residues affecting the luciferin binding, and the residues affecting the bioluminescence color were smaller on the nanofabricated hydrophilic Si surface than on both a hydrophobic Si surface and a hydrophilic Si surface. The nanofabrication and wet-treatment techniques are expected to prevent the decrease in activity of luciferase on the Si surface.

  17. The synthesis of active biomaterials through nanofabrication and sol-gel encapsulation of liposomes and membrane proteins

    NASA Astrophysics Data System (ADS)

    Soong, Ricky Kai

    The following dissertation reveals the latest advancements in developing self-sustaining hybrid nano-systems. Three areas of research were initiated: (1) Dielectrophoretic (DEP) mediation of hybrid assembly, (2) Solar powered proton pumping films, and (3) Silica materials with biochemical output for integration with nano-devices. The first topic of research was devoted to creating reliable hybridization platforms. This was achieved by implementing AC electric-field forces. One of the primary considerations in utilizing DEP is buffer conductivity. The initial medium used to preserve biomotor functionality was too conductive and AC field effects were significantly reduced. Subsequent testing with lower ionic strength indicated that the biomolecules were repelled from field intense regions. Hence, nano-electrode arrays were reconfigured to trap device components. Initial results showed promising potential but current lithographic limitations require new nanofabrication methodologies to obtain the desired electrode design. The second research project was focused on creating solar powered biomaterials. Liposomes containing bR proton pumping proteins and pyranine fluorescent dye into phospholipid vesicles were encapsulated within a silica matrix. The characteristic 402/456 nm pyranine peaks blue shifted upon acidification by bR. The proteoliposomes were mixed in a 3:1 ratio with tetramethyl orthosilicate (TMOS) sol respectively to provide a solar powered thin proteogel films. Ultimately, the ability to prepare these proteogels enabled the establishment of a proton gradient, and therefore opportunities to use these materials for biologically based power generation. The third research project involved engineering nanobiochemical reaction environments within a three-dimensional construct. The goal here was to recruit encapsulated enzymes to actively synthesize biochemical compounds. These compounds were subsequently collected and used as a fuel source for integrated nano

  18. Development of metal-assisted chemical etching of silicon as a 3D nanofabrication platform

    NASA Astrophysics Data System (ADS)

    Hildreth, Owen James

    The considerable interest in nanomaterials and nanotechnology over the last decade is attributed to Industry's desire for lower cost, more sophisticated devices and the opportunity that nanotechnology presents for scientists to explore the fundamental properties of nature at near atomic levels. In pursuit of these goals, researchers around the world have worked to both perfect existing technologies and also develop new nano-fabrication methods; however, no technique exists that is capable of producing complex, 2D and 3D nano-sized features of arbitrary shape, with smooth walls, and at low cost. This in part is due to two important limitations of current nanofabrication methods. First, 3D geometry is difficult if not impossible to fabricate, often requiring multiple lithography steps that are both expensive and do not scale well to industrial level fabrication requirements. Second, as feature sizes shrink into the nano-domain, it becomes increasingly difficult to accurately maintain those features over large depths and heights. The ability to produce these structures affordably and with high precision is critically important to a number of existing and emerging technologies such as metamaterials, nano-fluidics, nano-imprint lithography, and more. To overcome these limitations, this study developed a novel and efficient method to etch complex 2D and 3D geometry in silicon with controllable sub-micron to nano-sized features with aspect ratios in excess of 500:1. This study utilized Metal-assisted Chemical Etching (MaCE) of silicon in conjunction with shape-controlled catalysts to fabricate structures such as 3D cycloids, spirals, sloping channels, and out-of-plane rotational structures. This study focused on taking MaCE from a method to fabricate small pores and silicon nanowires using metal catalyst nanoparticles and discontinuous thin films, to a powerful etching technology that utilizes shaped catalysts to fabricate complex, 3D geometry using a single lithography

  19. Low temperature silicon dioxide deposition using tetramethylsilane for micro- and nanofabrication applications

    NASA Astrophysics Data System (ADS)

    Lin, Xin

    This thesis explores low temperature, plasma-enhanced chemical vapor deposited (PECVD) silicon dioxide thin films using tetramethylsilane (TMS), Si(CH3)4, as the silicon precursor for micro- and nanofabrication applications. A plasma chemistry model has been developed on the basis of the deposition rate behavior observed in the experiments. The oxygen plasma characteristics are shown to play a key role in oxide deposition with a low TMS concentration. Oxide formation occurs via two competing pathways: atom-induced deposition and ion-induced deposition. Their relative contributions vary with deposition conditions. The ion-induced deposition rate increases with substrate temperature but decreases when deposition pressure increases. In contrast, the atom-induced deposition rate decreases with increasing temperature but increases with pressure. Electrical, optical, chemical, mechanical properties as well as the conformality of the PECVD TMS oxide films were systematically investigated with substrate temperatures varying from 100°C to 200°C and deposition pressures changing from 2 Torr to 8 Torr The I-V characteristics of deposited oxide films degrade with decreasing substrate temperature and/or increasing deposition pressure due to a reduction of the film density and increase of the Si-OH concentration in the oxide films, which was verified with the FTIR spectra, wet-etch rate, refractive index, and dielectric constant. The C-V characteristics also deteriorate with lower substrate temperatures. However, the best C-V characteristic was obtained with a medium pressure of 3 Torr in this thesis study because of moderate ion-bombardment that helps the formation of high quality Si/SiO2 interface. The PECVD TMS oxide films exhibit moderate tensile intrinsic stress, whose variation with deposition conditions is consistent with changes in the film density and Si-OH concentration. The film conformality strongly depends on the deposition pressure and temperature. The best

  20. From integrative bioethics to pseudoscience.

    PubMed

    Bracanović, Tomislav

    2012-12-01

    Integrative bioethics is a brand of bioethics conceived and propagated by a group of Croatian philosophers and other scholars. This article discusses and shows that the approach encounters several serious difficulties. In criticizing certain standard views on bioethics and in presenting their own, the advocates of integrative bioethics fall into various conceptual confusions and inconsistencies. Although presented as a project that promises to deal with moral dilemmas created by modern science and technology, integrative bioethics does not contain the slightest normativity or action-guiding capacity. Portrayed as a scientific and interdisciplinary enterprise, integrative bioethics displays a large number of pseudoscientific features that throw into doubt its overall credibility. PMID:22708689

  1. Nanofabrication of Point Contact Junctions for Spectroscopic Studies of High-Temperature Superconductors

    NASA Astrophysics Data System (ADS)

    Zhao, Han; Mehio, Omar; Park, Wan Kyu; Eckstein, James; Greene, Laura

    Point contact spectroscopy (PCS) probes the superconducting order parameter from Andreev reflection conductance spectrum. A new method to achieve robust junctions with a precise control of the geometry of the point contact by focused ion beam (FIB) nanofabrication techniques is currently under development. Preliminary application on niobium thin films shows consistent data that is insensitive to thermal cycling. This opens the possibility to perform PCS on a series of materials as a function of external variables, including temperature, magnetic field as a function of angle, and stress. Our preliminary data as a function of junction size show the expected resistance dependence, which will help us to determine more precisely when junctions are in the ballistic, or spectroscopic regime. Our plan is to apply this newly-developed method to probe the electronic nematic state in iron-based superconductors under applied magnetic field and uniaxial stress, to further understand the origin of the nematicity. This work is carried out in part in the Materials Research Lab, University of Illinois and is supported by the Center for Emergent Superconductivity, an Energy Frontier Research Center funded by the US DOE, Office of Science, Award No. DE-AC0298CH1088.

  2. Nanofabrication and coloration study of artificial Morpho butterfly wings with aligned lamellae layers

    NASA Astrophysics Data System (ADS)

    Zhang, Sichao; Chen, Yifang

    2015-11-01

    The bright and iridescent blue color from Morpho butterfly wings has attracted worldwide attentions to explore its mysterious nature for long time. Although the physics of structural color by the nanophotonic structures built on the wing scales has been well established, replications of the wing structure by standard top-down lithography still remains a challenge. This paper reports a technical breakthrough to mimic the blue color of Morpho butterfly wings, by developing a novel nanofabrication process, based on electron beam lithography combined with alternate PMMA/LOR development/dissolution, for photonic structures with aligned lamellae multilayers in colorless polymers. The relationship between the coloration and geometric dimensions as well as shapes is systematically analyzed by solving Maxwell’s Equations with a finite domain time difference simulator. Careful characterization of the mimicked blue by spectral measurements under both normal and oblique angles are carried out. Structural color in blue reflected by the fabricated wing scales, is demonstrated and further extended to green as an application exercise of the new technique. The effects of the regularity in the replicas on coloration are analyzed. In principle, this approach establishes a starting point for mimicking structural colors beyond the blue in Morpho butterfly wings.

  3. Top-Down Nanofabrication and Characterization of 20 nm Silicon Nanowires for Biosensing Applications

    PubMed Central

    M. N, M. Nuzaihan; Hashim, U.; Md Arshad, M. K.; Ruslinda, A. Rahim; Rahman, S. F. A.; Fathil, M. F. M.; Ismail, Mohd. H.

    2016-01-01

    A top-down nanofabrication approach is used to develop silicon nanowires from silicon-on-insulator (SOI) wafers and involves direct-write electron beam lithography (EBL), inductively coupled plasma-reactive ion etching (ICP-RIE) and a size reduction process. To achieve nanometer scale size, the crucial factors contributing to the EBL and size reduction processes are highlighted. The resulting silicon nanowires, which are 20 nm in width and 30 nm in height (with a triangular shape) and have a straight structure over the length of 400 μm, are fabricated precisely at the designed location on the device. The device is applied in biomolecule detection based on the changes in drain current (Ids), electrical resistance and conductance of the silicon nanowires upon hybridization to complementary target deoxyribonucleic acid (DNA). In this context, the scaled-down device exhibited superior performances in terms of good specificity and high sensitivity, with a limit of detection (LOD) of 10 fM, enables for efficient label-free, direct and higher-accuracy DNA molecules detection. Thus, this silicon nanowire can be used as an improved transducer and serves as novel biosensor for future biomedical diagnostic applications. PMID:27022732

  4. Parallel computation with molecular-motor-propelled agents in nanofabricated networks

    PubMed Central

    Nicolau, Dan V.; Lard, Mercy; Korten, Till; van Delft, Falco C. M. J. M.; Persson, Malin; Bengtsson, Elina; Månsson, Alf; Diez, Stefan; Linke, Heiner; Nicolau, Dan V.

    2016-01-01

    The combinatorial nature of many important mathematical problems, including nondeterministic-polynomial-time (NP)-complete problems, places a severe limitation on the problem size that can be solved with conventional, sequentially operating electronic computers. There have been significant efforts in conceiving parallel-computation approaches in the past, for example: DNA computation, quantum computation, and microfluidics-based computation. However, these approaches have not proven, so far, to be scalable and practical from a fabrication and operational perspective. Here, we report the foundations of an alternative parallel-computation system in which a given combinatorial problem is encoded into a graphical, modular network that is embedded in a nanofabricated planar device. Exploring the network in a parallel fashion using a large number of independent, molecular-motor-propelled agents then solves the mathematical problem. This approach uses orders of magnitude less energy than conventional computers, thus addressing issues related to power consumption and heat dissipation. We provide a proof-of-concept demonstration of such a device by solving, in a parallel fashion, the small instance {2, 5, 9} of the subset sum problem, which is a benchmark NP-complete problem. Finally, we discuss the technical advances necessary to make our system scalable with presently available technology. PMID:26903637

  5. Nanofabrication and coloration study of artificial Morpho butterfly wings with aligned lamellae layers

    PubMed Central

    Zhang, Sichao; Chen, Yifang

    2015-01-01

    The bright and iridescent blue color from Morpho butterfly wings has attracted worldwide attentions to explore its mysterious nature for long time. Although the physics of structural color by the nanophotonic structures built on the wing scales has been well established, replications of the wing structure by standard top-down lithography still remains a challenge. This paper reports a technical breakthrough to mimic the blue color of Morpho butterfly wings, by developing a novel nanofabrication process, based on electron beam lithography combined with alternate PMMA/LOR development/dissolution, for photonic structures with aligned lamellae multilayers in colorless polymers. The relationship between the coloration and geometric dimensions as well as shapes is systematically analyzed by solving Maxwell’s Equations with a finite domain time difference simulator. Careful characterization of the mimicked blue by spectral measurements under both normal and oblique angles are carried out. Structural color in blue reflected by the fabricated wing scales, is demonstrated and further extended to green as an application exercise of the new technique. The effects of the regularity in the replicas on coloration are analyzed. In principle, this approach establishes a starting point for mimicking structural colors beyond the blue in Morpho butterfly wings. PMID:26577813

  6. Nanofabrication and coloration study of artificial Morpho butterfly wings with aligned lamellae layers.

    PubMed

    Zhang, Sichao; Chen, Yifang

    2015-01-01

    The bright and iridescent blue color from Morpho butterfly wings has attracted worldwide attentions to explore its mysterious nature for long time. Although the physics of structural color by the nanophotonic structures built on the wing scales has been well established, replications of the wing structure by standard top-down lithography still remains a challenge. This paper reports a technical breakthrough to mimic the blue color of Morpho butterfly wings, by developing a novel nanofabrication process, based on electron beam lithography combined with alternate PMMA/LOR development/dissolution, for photonic structures with aligned lamellae multilayers in colorless polymers. The relationship between the coloration and geometric dimensions as well as shapes is systematically analyzed by solving Maxwell's Equations with a finite domain time difference simulator. Careful characterization of the mimicked blue by spectral measurements under both normal and oblique angles are carried out. Structural color in blue reflected by the fabricated wing scales, is demonstrated and further extended to green as an application exercise of the new technique. The effects of the regularity in the replicas on coloration are analyzed. In principle, this approach establishes a starting point for mimicking structural colors beyond the blue in Morpho butterfly wings. PMID:26577813

  7. Structural transformation by electrodeposition on patterned substrates (STEPS): a new versatile nanofabrication method.

    PubMed

    Kim, Philseok; Epstein, Alexander K; Khan, Mughees; Zarzar, Lauren D; Lipomi, Darren J; Whitesides, George M; Aizenberg, Joanna

    2012-02-01

    Arrays of high-aspect-ratio (HAR) nano- and microstructures are of great interest for designing surfaces for applications in optics, bio-nano interfaces, microelectromechanical systems, and microfluidics, but the difficulty of systematically and conveniently varying the geometries of these structures significantly limits their design and optimization for a specific function. This paper demonstrates a low-cost, high-throughput benchtop method that enables a HAR array to be reshaped with nanoscale precision by electrodeposition of conductive polymers. The method-named STEPS (structural transformation by electrodeposition on patterned substrates)-makes it possible to create patterns with proportionally increasing size of original features, to convert isolated HAR features into a closed-cell substrate with a continuous HAR wall, and to transform a simple parent two-dimensional HAR array into new three-dimensional patterned structures with tapered, tilted, anisotropic, or overhanging geometries by controlling the deposition conditions. We demonstrate the fabrication of substrates with continuous or discrete gradients of nanostructure features, as well as libraries of various patterns, starting from a single master structure. By providing exemplary applications in plasmonics, bacterial patterning, and formation of mechanically reinforced structures, we show that STEPS enables a wide range of studies of the effect of substrate topography on surface properties leading to optimization of the structures for a specific application. This research identifies solution-based deposition of conductive polymers as a new tool in nanofabrication and allows access to 3D architectures that were previously difficult to fabricate. PMID:21438614

  8. Parallel computation with molecular-motor-propelled agents in nanofabricated networks.

    PubMed

    Nicolau, Dan V; Lard, Mercy; Korten, Till; van Delft, Falco C M J M; Persson, Malin; Bengtsson, Elina; Månsson, Alf; Diez, Stefan; Linke, Heiner; Nicolau, Dan V

    2016-03-01

    The combinatorial nature of many important mathematical problems, including nondeterministic-polynomial-time (NP)-complete problems, places a severe limitation on the problem size that can be solved with conventional, sequentially operating electronic computers. There have been significant efforts in conceiving parallel-computation approaches in the past, for example: DNA computation, quantum computation, and microfluidics-based computation. However, these approaches have not proven, so far, to be scalable and practical from a fabrication and operational perspective. Here, we report the foundations of an alternative parallel-computation system in which a given combinatorial problem is encoded into a graphical, modular network that is embedded in a nanofabricated planar device. Exploring the network in a parallel fashion using a large number of independent, molecular-motor-propelled agents then solves the mathematical problem. This approach uses orders of magnitude less energy than conventional computers, thus addressing issues related to power consumption and heat dissipation. We provide a proof-of-concept demonstration of such a device by solving, in a parallel fashion, the small instance {2, 5, 9} of the subset sum problem, which is a benchmark NP-complete problem. Finally, we discuss the technical advances necessary to make our system scalable with presently available technology. PMID:26903637

  9. Top-Down Nanofabrication and Characterization of 20 nm Silicon Nanowires for Biosensing Applications.

    PubMed

    M Nuzaihan, M N; Hashim, U; Md Arshad, M K; Rahim Ruslinda, A; Rahman, S F A; Fathil, M F M; Ismail, Mohd H

    2016-01-01

    A top-down nanofabrication approach is used to develop silicon nanowires from silicon-on-insulator (SOI) wafers and involves direct-write electron beam lithography (EBL), inductively coupled plasma-reactive ion etching (ICP-RIE) and a size reduction process. To achieve nanometer scale size, the crucial factors contributing to the EBL and size reduction processes are highlighted. The resulting silicon nanowires, which are 20 nm in width and 30 nm in height (with a triangular shape) and have a straight structure over the length of 400 μm, are fabricated precisely at the designed location on the device. The device is applied in biomolecule detection based on the changes in drain current (Ids), electrical resistance and conductance of the silicon nanowires upon hybridization to complementary target deoxyribonucleic acid (DNA). In this context, the scaled-down device exhibited superior performances in terms of good specificity and high sensitivity, with a limit of detection (LOD) of 10 fM, enables for efficient label-free, direct and higher-accuracy DNA molecules detection. Thus, this silicon nanowire can be used as an improved transducer and serves as novel biosensor for future biomedical diagnostic applications. PMID:27022732

  10. MEMS-enabled Dip Pen Nanolithography for directed nanoscale deposition and high-throughput nanofabrication

    NASA Astrophysics Data System (ADS)

    Haaheim, J. R.; Nafday, O. A.; Levesque, T.; Fragala, J.; Shile, R.

    2009-02-01

    Precision nanoscale deposition is a fundamental requirement for nanoscience research, development, and commercial implementation. Dip Pen Nanolithography(R) (DPN) is an inherently additive SPM-based technique which operates under ambient conditions, making it suitable to deposit a wide range of biological and inorganic materials. This technique is fundamentally enabled by a portfolio of MEMS devices tailored for microfluidic ink delivery, directed placement of nanoscale materials via actuated cantilevers, and cm2 tip arrays for high-throughput nanofabrication. Multiplexed deposition of nanoscale materials is a challenging problem, but we have implemented InkWells(TM) to enable selective delivery of ink materials to different tips in multiple probe arrays, while preventing cross-contamination. Active Pens(TM) can take advantage of this, directly place a variety of materials in nanoscale proximity, and do so in a "clean" fashion since the cantilevers can be manipulated in Z. Further, massively parallel two-dimensional nanopatterning with DPN is now commercially available via NanoInk's 2D nano PrintArray(TM), making DPN a highthroughput, flexible and versatile method for precision nanoscale pattern formation. By fabricating 55,000 tip-cantilevers across a 1 cm2 chip, we leverage the inherent versatility of DPN and demonstrate large area surface coverage, routinely achieving throughputs of 3×107 μm2 per hour. Further, we have engineered the device to be easy to use, wire-free, and fully integrated with the NSCRIPTOR's scanner, stage, and sophisticated lithography routines. In this talk we discuss the methods of operating this commercially available device, and subsequent results showing sub-100 nm feature sizes and excellent uniformity (standard deviation < 16%). Finally, we will discuss applications enabled by this MEMS portfolio including: 1) rapidly and flexibly generating nanostructures; 2) chemically directed assembly and 3) directly writing biological materials.

  11. Measuring Integrated Information from the Decoding Perspective

    PubMed Central

    Oizumi, Masafumi; Amari, Shun-ichi; Yanagawa, Toru; Fujii, Naotaka; Tsuchiya, Naotsugu

    2016-01-01

    Accumulating evidence indicates that the capacity to integrate information in the brain is a prerequisite for consciousness. Integrated Information Theory (IIT) of consciousness provides a mathematical approach to quantifying the information integrated in a system, called integrated information, Φ. Integrated information is defined theoretically as the amount of information a system generates as a whole, above and beyond the amount of information its parts independently generate. IIT predicts that the amount of integrated information in the brain should reflect levels of consciousness. Empirical evaluation of this theory requires computing integrated information from neural data acquired from experiments, although difficulties with using the original measure Φ precludes such computations. Although some practical measures have been previously proposed, we found that these measures fail to satisfy the theoretical requirements as a measure of integrated information. Measures of integrated information should satisfy the lower and upper bounds as follows: The lower bound of integrated information should be 0 and is equal to 0 when the system does not generate information (no information) or when the system comprises independent parts (no integration). The upper bound of integrated information is the amount of information generated by the whole system. Here we derive the novel practical measure Φ* by introducing a concept of mismatched decoding developed from information theory. We show that Φ* is properly bounded from below and above, as required, as a measure of integrated information. We derive the analytical expression of Φ* under the Gaussian assumption, which makes it readily applicable to experimental data. Our novel measure Φ* can generally be used as a measure of integrated information in research on consciousness, and also as a tool for network analysis on diverse areas of biology. PMID:26796119

  12. Measuring Integrated Information from the Decoding Perspective.

    PubMed

    Oizumi, Masafumi; Amari, Shun-ichi; Yanagawa, Toru; Fujii, Naotaka; Tsuchiya, Naotsugu

    2016-01-01

    Accumulating evidence indicates that the capacity to integrate information in the brain is a prerequisite for consciousness. Integrated Information Theory (IIT) of consciousness provides a mathematical approach to quantifying the information integrated in a system, called integrated information, Φ. Integrated information is defined theoretically as the amount of information a system generates as a whole, above and beyond the amount of information its parts independently generate. IIT predicts that the amount of integrated information in the brain should reflect levels of consciousness. Empirical evaluation of this theory requires computing integrated information from neural data acquired from experiments, although difficulties with using the original measure Φ precludes such computations. Although some practical measures have been previously proposed, we found that these measures fail to satisfy the theoretical requirements as a measure of integrated information. Measures of integrated information should satisfy the lower and upper bounds as follows: The lower bound of integrated information should be 0 and is equal to 0 when the system does not generate information (no information) or when the system comprises independent parts (no integration). The upper bound of integrated information is the amount of information generated by the whole system. Here we derive the novel practical measure Φ* by introducing a concept of mismatched decoding developed from information theory. We show that Φ* is properly bounded from below and above, as required, as a measure of integrated information. We derive the analytical expression of Φ* under the Gaussian assumption, which makes it readily applicable to experimental data. Our novel measure Φ* can generally be used as a measure of integrated information in research on consciousness, and also as a tool for network analysis on diverse areas of biology. PMID:26796119

  13. Soft X-Ray (1-7 nm) Solar Spectrometer based on novel Nanowriter Electron-Beam Nanofabrication Technology

    NASA Astrophysics Data System (ADS)

    Didkovsky, L. V.; Wieman, S. R.; Chao, W.

    2015-12-01

    A new soft X-ray (SXR) spectrometer combines proven detector technology demonstrated on the SOHO Solar EUV Monitor (SOHO/SEM) and SDO EUV SpectroPhotometer (SDO/EVE/ESP) instruments with novel technology for X-ray optics nanofabrication developed at the Lawrence Berkeley National Laboratory. The new spectrometer will provide solar SXR measurements of absolute irradiance in the 1.0 to 7.0 nm range spectrally resolved into bands narrower than 1 nm - measurements that are not available from existing solar-observing instruments but are important for studying and modeling coronal dynamics and the Sun-Earth's connection, e.g. the Earth's Ionosphere. For the proposed SXR spectrometer we will introduce a transmission grating based on novel Nanowriter Electron-Beam Nanofabrication technology developed at the Center for X-ray Optics (CXRO) at the Lawrence Berkeley National Laboratory. The CXRO technology has been used in the fabrication of X-ray zone plates with feature sizes as small as 25 nm in optical elements with overall sizes on the order of 1 cm. The CXRO technology has significant flexibility in terms of pattern geometry, and is thus capable of producing linear transmission gratings with aperture sizes similar to SEM and ESP but with four times the dispersion. With such dispersion, reasonable spectral resolution (< 1nm) can be obtained using commercial off-the shelf (COTS) X-ray sensitive AXUV type silicon photodiodes from the Optodiode Corp. in an instrument with overall size and mass similar to that of SEM or ESP.

  14. Monolithic optofluidic ring resonator lasers created by femtosecond laser nanofabrication.

    PubMed

    Chandrahalim, Hengky; Chen, Qiushu; Said, Ali A; Dugan, Mark; Fan, Xudong

    2015-05-21

    We designed, fabricated, and characterized a monolithically integrated optofluidic ring resonator laser that is mechanically, thermally, and chemically robust. The entire device, including the ring resonator channel and sample delivery microfluidics, was created in a block of fused-silica glass using a 3-dimensional femtosecond laser writing process. The gain medium, composed of Rhodamine 6G (R6G) dissolved in quinoline, was flowed through the ring resonator. Lasing was achieved at a pump threshold of approximately 15 μJ mm(-2). Detailed analysis shows that the Q-factor of the optofluidic ring resonator is 3.3 × 10(4), which is limited by both solvent absorption and scattering loss. In particular, a Q-factor resulting from the scattering loss can be as high as 4.2 × 10(4), suggesting the feasibility of using a femtosecond laser to create high quality optical cavities. PMID:25904381

  15. Removing Bonded Integrated Circuits From Boards

    NASA Technical Reports Server (NTRS)

    Rice, John T.

    1989-01-01

    Small resistance heater makes it easier, faster, and cheaper to remove integrated circuit from hybrid-circuit board, package, or other substrate for rework. Heater, located directly in polymeric bond interface or on substrate under integrated-circuit chip, energized when necessary to remove chip. Heat generated softens adhesive or solder that bonds chip to substrate. Chip then lifted easily from substrate.

  16. Nanofabrication using home-made RF plasma coupled chemical vapour deposition system

    NASA Astrophysics Data System (ADS)

    Ong, Si Ci; Ilyas, Usman; Rawat, Rajdeep Singh

    2014-08-01

    Zinc oxide, ZnO, a popular semiconductor material with a wide band gap (3.37 eV) and high binding energy of the exciton (60 meV), has numerous applications such as in optoelectronics, chemical/biological sensors, and drug delivery. This project aims to (i) optimize the operating conditions for growth of ZnO nanostructures using the chemical vapor deposition (CVD) method, and (ii) investigate the effects of coupling radiofrequency (RF) plasma to the CVD method on the quality of ZnO nanostructures. First, ZnO nanowires were synthesized using a home-made reaction setup on gold-coated and non-coated Si (100) substrates at 950 °C. XRD, SEM, EDX, and PL measurements were used for characterizations and it was found that a deposition duration of 10 minutes produced the most well-defined ZnO nanowires. SEM analysis revealed that the nanowires had diameters ranging from 30-100 mm and lengths ranging from 1-4 µm. In addition, PL analysis showed strong UV emission at 380 nm, making it suitable for UV lasing. Next, RF plasma was introduced for 30 minutes. Both remote and in situ RF plasma produced less satisfactory ZnO nanostructures with poorer crystalline structure, surface morphology, and optical properties due to etching effect of energetic ions produced from plasma. However, a reduction in plasma discharge duration to 10 minutes produced thicker and shorter ZnO nanostructures. Based on experimentation conducted, it is insufficient to conclude that RF plasma cannot aid in producing well-defined ZnO nanostructures. It can be deduced that the etching effect of energetic ions outweighed the increased oxygen radical production in RF plasma nanofabrication.

  17. Constraining ultralarge-scale cosmology with multiple tracers in optical and radio surveys

    NASA Astrophysics Data System (ADS)

    Alonso, D.; Ferreira, P. G.

    2015-09-01

    Multiple tracers of the cosmic density field, with different bias, number and luminosity evolution, can be used to measure the large-scale properties of the Universe. We show how an optimal combination of tracers can be used to detect general-relativistic effects in the observed density of sources. We forecast for the detectability of these effects, as well as measurements of primordial non-Gaussianity and large-scale lensing magnification with current and upcoming large-scale structure experiments. In particular we quantify the significance of these detections in the short term with experiments such as the Dark Energy Survey (DES), and in the long term with the Large Synoptic Survey Telescope (LSST) and the Square Kilometre Array (SKA). We review the main observational challenges that must be overcome to carry out these measurements.

  18. Recovering a function from its trigonometric integral

    NASA Astrophysics Data System (ADS)

    Sworowska, Tat'yana A.

    2010-09-01

    The approximate symmetric Henstock-Kurzweil integral is shown as solving the problem of the recovery of a function from its trigonometric integral. This being so, we generalize Offord's theorem, which is an analogue of de la Vallée Poussin's theorem for trigonometric series. A new condition for a function to be representable by a singular Fourier integral is also obtained.Bibliography: 10 titles.

  19. A beam flexure-based nanopositioning stage supporting laser direct-write nanofabrication

    NASA Astrophysics Data System (ADS)

    Zhang, Zhen; Wang, Peng; Yan, Peng; Guan, YingChun

    2016-08-01

    A nanopositioning system of both millimetric stroke and nanometric tracking accuracy is a key component for nanofabrication in many applications. In this paper, a novel bi-axial beam-flexure nano servo stage is proposed to support a direct writing system for femtosecond laser nanofabrication. The important features of the stage lie in: a mirror symmetric instead of rotational symmetric configuration is adopted to restrict cross axis coupling, and a novel Z-shaped guidance module is proposed to achieve relative large linear stiffness range, in addition a redundant constraints module is introduced to increase off-axis stiffness of the stage. Mechanical analysis and system identification are provided, with which a feedback control algorithm demonstrates the tracking capability for laser fabrication purposes. Based on the fabricated XY nano-stage, real time control and measurements are deployed, demonstrating the millimetric operating workspace and 77.8 nm (RMS) error of tracking a circular trajectory.

  20. Nanofabrication of heteromolecular organic nanostructures on epitaxial graphene via room temperature feedback-controlled lithography.

    PubMed

    Wang, Qing Hua; Hersam, Mark C

    2011-02-01

    Nanoscale control of surface chemistry holds promise for tailoring the electronic, optical, and chemical properties of graphene. Toward this end, the nanofabrication of sub-5-nm heteromolecular organic nanostructures is demonstrated on epitaxial graphene using room temperature ultrahigh vacuum scanning tunneling microscopy. In particular, monolayers of the organic semiconductor 3,4,9,10-perylene-tetracarboxylic dianhydride (PTCDA) are nanopatterned on epitaxial graphene using feedback-controlled lithography (FCL) and then used as chemical resists to template the deposition of N,N'-dioctyl-3,4,9,10-perylene-tetracarboxylic diimide (PTCDI-C8). The generality of this FCL-based nanofabrication procedure suggests its applicability to a wide range of fundamental studies and prototype device fabrication on chemically functionalized graphene. PMID:21166423

  1. Arbitrary and Parallel Nanofabrication of 3D Metal Structures with Polymer Brush Resists.

    PubMed

    Chen, Chaojian; Xie, Zhuang; Wei, Xiaoling; Zheng, Zijian

    2015-12-01

    3D polymer brushes are reported for the first time as ideal resists for the alignment-free nanofabrication of complex 3D metal structures with sub-100 nm lateral resolution and sub-10 nm vertical resolution. Since 3D polymer brushes can be serially fabricated in parallel, this method is effective to generate arbitrary 3D metal structures over a large area at a high throughput. PMID:26439441

  2. Manual, In situ, Real-Time Nanofabrication using Cracking through Indentation

    PubMed Central

    Nam, Koo Hyun; Suh, Young D.; Yeo, Junyeob; Woo, Deokha

    2016-01-01

    Nanofabrication has seen an increasing demand for applications in many fields of science and technology, but its production still requires relatively difficult, time-consuming, and expensive processes. Here we report a simple but very effective one dimensional (1D) nano-patterning technology that suggests a new nanofabrication method. This new technique involves the control of naturally propagating cracks initiated through simple, manually generated indentation, obviating the necessity of complicated equipment and elaborate experimental environments such as those that employ clean rooms, high vacuums, and the fastidious maintenance of processing temperatures. The channel fabricated with this technique can be as narrow as 10 nm with unlimited length and very high cross-sectional aspect ratio, an accomplishment difficult even for a state-of-the-art technology such as e-beam lithography. More interestingly, the fabrication speed can be controlled and achieved to as little as several hundred micrometers per second. Along with the simplicity and real-time fabrication capability of the technique, this tunable fabrication speed makes the method introduced here the authentic nanofabrication for in situ experiments. PMID:26725520

  3. Manual, In situ, Real-Time Nanofabrication using Cracking through Indentation

    NASA Astrophysics Data System (ADS)

    Nam, Koo Hyun; Suh, Young D.; Yeo, Junyeob; Woo, Deokha

    2016-01-01

    Nanofabrication has seen an increasing demand for applications in many fields of science and technology, but its production still requires relatively difficult, time-consuming, and expensive processes. Here we report a simple but very effective one dimensional (1D) nano-patterning technology that suggests a new nanofabrication method. This new technique involves the control of naturally propagating cracks initiated through simple, manually generated indentation, obviating the necessity of complicated equipment and elaborate experimental environments such as those that employ clean rooms, high vacuums, and the fastidious maintenance of processing temperatures. The channel fabricated with this technique can be as narrow as 10 nm with unlimited length and very high cross-sectional aspect ratio, an accomplishment difficult even for a state-of-the-art technology such as e-beam lithography. More interestingly, the fabrication speed can be controlled and achieved to as little as several hundred micrometers per second. Along with the simplicity and real-time fabrication capability of the technique, this tunable fabrication speed makes the method introduced here the authentic nanofabrication for in situ experiments.

  4. Computation of virial coefficients from integral equations.

    PubMed

    Zhang, Cheng; Lai, Chun-Liang; Pettitt, B Montgomery

    2015-06-01

    A polynomial-time method of computing the virial coefficients from an integral equation framework is presented. The method computes the truncated density expansions of the correlation functions by series transformations, and then extracts the virial coefficients from the density components. As an application, the method was used in a hybrid-closure integral equation with a set of self-consistent conditions, which produced reasonably accurate virial coefficients for the hard-sphere fluid and Gaussian model in high dimensions. PMID:26049482

  5. Computation of virial coefficients from integral equations

    NASA Astrophysics Data System (ADS)

    Zhang, Cheng; Lai, Chun-Liang; Pettitt, B. Montgomery

    2015-06-01

    A polynomial-time method of computing the virial coefficients from an integral equation framework is presented. The method computes the truncated density expansions of the correlation functions by series transformations, and then extracts the virial coefficients from the density components. As an application, the method was used in a hybrid-closure integral equation with a set of self-consistent conditions, which produced reasonably accurate virial coefficients for the hard-sphere fluid and Gaussian model in high dimensions.

  6. Integrating data from heterogeneous DNA microarray platforms.

    PubMed

    Valente, Eduardo; Rocha, Miguel

    2015-01-01

    DNA microarrays are one of the most used technologies for gene expression measurement. However, there are several distinct microarray platforms, from different manufacturers, each with its own measurement protocol, resulting in data that can hardly be compared or directly integrated. Data integration from multiple sources aims to improve the assertiveness of statistical tests, reducing the data dimensionality problem. The integration of heterogeneous DNA microarray platforms comprehends a set of tasks that range from the re-annotation of the features used on gene expression, to data normalization and batch effect elimination. In this work, a complete methodology for gene expression data integration and application is proposed, which comprehends a transcript-based re-annotation process and several methods for batch effect attenuation. The integrated data will be used to select the best feature set and learning algorithm for a brain tumor classification case study. The integration will consider data from heterogeneous Agilent and Affymetrix platforms, collected from public gene expression databases, such as The Cancer Genome Atlas and Gene Expression Omnibus. PMID:26673932

  7. EMBA Integration: From Rhetoric to Practice

    ERIC Educational Resources Information Center

    Scott, Charles; Derrick, Frederick; Hoadley, Ellen

    2012-01-01

    For the modern business world, business education needs to molt from the cocoon of discipline silos to the integrated business education model to train the next generation of managers. Upper management problems are rarely silo specific. Managers do things right, but leaders do the right things; and executive programs exist to build business…

  8. Tip-Based Nanofabrication of Arbitrary Shapes of Graphene Nanoribbons for Device Applications

    PubMed Central

    Estrada, David; Bashir, Rashid; King, William P.

    2015-01-01

    Graphene nanoribbons (GNRs) have promising applications in future nanoelectronics, chemical sensing and electrical interconnects. Although there are quite a few GNR nanofabrication methods reported, a rapid and low-cost fabrication method that is capable of fabricating arbitrary shapes of GNRs with good-quality is still in demand for using GNRs for device applications. In this paper, we present a tip-based nanofabrication method capable of fabricating arbitrary shapes of GNRs. A heated atomic force microscope (AFM) tip deposits polymer nanowires atop a CVD-grown graphene surface. The polymer nanowires serve as an etch mask to define GNRs through one step of oxygen plasma etching similar to a photoresist in conventional photolithography. Various shapes of GNRs with either linear or curvilinear features are demonstrated. The width of the GNR is around 270 nm and is determined by the width of the depositing polymer nanowire, which we estimate can be scaled down 15 nms. We characterize our TBN-fabricated GNRs using Raman spectroscopy and I-V measurements. The measured sheet resistances of our GNRs fall within the range of 1.65 kΩ/□−1 – 2.64 kΩ/□−1, in agreement with previously reported values. Furthermore, we determined the high-field breakdown current density of GNRs to be approximately 2.94×108 A/cm2. This TBN process is seamlessly compatible with existing nanofabrication processes, and is particularly suitable for fabricating GNR based electronic devices including next generation DNA sequencing technologies and beyond silicon field effect transistors. PMID:26257891

  9. Nanofabrication and applications of subwavelength optical probes: Chemical and biological sensors, light sources and exciton probes

    SciTech Connect

    Tan, W.

    1993-01-01

    The author has developed a new and controllable nanofabrication technique, photo-nanofabrication, based on near-field photo-chemical synthesis and nanometer optical sources. Photo-nanofabrication can produce subwavelength light and exciton probes with or without specific chemical or biological sensitivity. By applying near-field optics, the author has successfully demonstrated a new concept of near-field photochemical synthesis, in which the dimension of a product is solely determined by the size of the light source. The most successful application to date is the development of the smallest fiberoptic chemical sensors. Specifically, a thousandfold miniaturization of an immobilized fiberoptic pH sensor has been achieved, leading to at least a millionfold decrease in necessary sample volume and to at least a hundredfold shorter response time. The sensors have high fluorescence intensity and excellent detection limit. New internal calibration methods have also been developed for accurate pH quantification. The newly developed optical sensors have been used in real time measurements of pH on individual, viable, intact rat conceptuses during the period of organogenesis. The sensors can discriminate pH changes of less than 0.1 pH unit in the physiologic pH range. Static determinations of pH in rat conceptuses of varying gestational ages show decreasing pH with conceptal age. Chemical dynamic alterations in pH of intact rat conceptuses, in response to several variations in their environmental conditions, have been measured. Passive and active subwavelength light sources have been constructed with both micropipettes and fiberoptic tips. They have been used as exciton and light sources and in preliminary probe-to-sample distance regulated, Foerster energy transfer studies as well as in studies of the probe-to-sample interfacial Kasha effect. They were also used in supertip development for near-field scanning optical microscopy and for molecular exciton microscopy.

  10. Study of Uremic Toxin Fluxes Across Nanofabricated Hemodialysis Membranes Using Irreversible Thermodynamics

    PubMed Central

    Hedayat, Assem; Peace, Rob; Elmoselhi, Hamdi; Shoker, Ahmed

    2013-01-01

    Introduction The flux of uremic toxin middle molecules through currently used hemodialysis membranes is suboptimal, mainly because of the membranes’ pore architecture. Aim Identifying the modifiable sieving parameters that can be improved by nanotechnology to enhance fluxes of uremic toxins across the walls of dialyzers’ capillaries. Methods We determined the maximal dimensions of endothelin, cystatin C, and interleukin – 6 using the macromolecular modeling software, COOT. We also applied the expanded Nernst-Plank equation to calculate the changes in the overall flux as a function of increased electro-migration and pH of the respective molecules. Results In a high flux hemodialyzer, the effective diffusivities of endothelin, cystatin C, and interleukin – 6 are 15.00 x 10-10 cm2/s, 7.7 x 10-10 cm2/s, and 5.4 x 10-10 cm2/s, respectively, through the capillaries’ walls. In a nanofabricated membrane, the effective diffusivities of endothelin, cystatin C, and interleukin – 6 are 13.87 x 10-7 cm2/s, 5.73 x 10-7 cm2/s, and 3.45 x 10-7 cm2/s, respectively, through a nanofabricated membrane. Theoretical modeling showed that a 96% reduction in the membrane's thickness and the application of an electric potential of 10 mV across the membrane could enhance the flux of endothelin, cystatin C, and interleukin - 6 by a factor of 25. A ΔpH of 0.07 altered the fluxes minimally. Conclusions Nanofabricated hemodialysis membranes with a reduced thickness and an applied electric potential can enhance the effective diffusivity and electro-migration flux of the respective uremic toxins by 3 orders of magnitude as compared to those passing through the high flux hemodialyzer. PMID:24688713

  11. Directing Matter: Toward Atomic-Scale 3D Nanofabrication.

    PubMed

    Jesse, Stephen; Borisevich, Albina Y; Fowlkes, Jason D; Lupini, Andrew R; Rack, Philip D; Unocic, Raymond R; Sumpter, Bobby G; Kalinin, Sergei V; Belianinov, Alex; Ovchinnikova, Olga S

    2016-06-28

    Enabling memristive, neuromorphic, and quantum-based computing as well as efficient mainstream energy storage and conversion technologies requires the next generation of materials customized at the atomic scale. This requires full control of atomic arrangement and bonding in three dimensions. The last two decades witnessed substantial industrial, academic, and government research efforts directed toward this goal through various lithographies and scanning-probe-based methods. These technologies emphasize 2D surface structures, with some limited 3D capability. Recently, a range of focused electron- and ion-based methods have demonstrated compelling alternative pathways to achieving atomically precise manufacturing of 3D structures in solids, liquids, and at interfaces. Electron and ion microscopies offer a platform that can simultaneously observe dynamic and static structures at the nano- and atomic scales and also induce structural rearrangements and chemical transformation. The addition of predictive modeling or rapid image analytics and feedback enables guiding these in a controlled manner. Here, we review the recent results that used focused electron and ion beams to create free-standing nanoscale 3D structures, radiolysis, and the fabrication potential with liquid precursors, epitaxial crystallization of amorphous oxides with atomic layer precision, as well as visualization and control of individual dopant motion within a 3D crystal lattice. These works lay the foundation for approaches to directing nanoscale level architectures and offer a potential roadmap to full 3D atomic control in materials. In this paper, we lay out the gaps that currently constrain the processing range of these platforms, reflect on indirect requirements, such as the integration of large-scale data analysis with theory, and discuss future prospects of these technologies. PMID:27183171

  12. Directing Matter: Toward Atomic-Scale 3D Nanofabrication

    DOE PAGESBeta

    Jesse, Stephen; Borisevich, Albina Y.; Fowlkes, Jason D.; Lupini, Andrew R.; Rack, Philip D.; Unocic, Raymond R.; Sumpter, Bobby G.; Kalinin, Sergei V.; Belianinov, Alex; Ovchinnikova, Olga S.

    2016-05-16

    Here we report that enabling memristive, neuromorphic, and quantum based computing as well as efficient mainstream energy storage and conversion technologies requires next generation of materials customized at the atomic scale. This requires full control of atomic arrangement and bonding in three dimensions. The last two decades witnessed substantial industrial, academic, and government research efforts directed towards this goal through various lithographies and scanning probe based methods. These technologies emphasize 2D surface structures, with some limited 3D capability. Recently, a range of focused electron and ion based methods have demonstrated compelling alternative pathways to achieving atomically precise manufacturing of 3Dmore » structures in solids, liquids, and at interfaces. Electron and ion microscopies offer a platform that can simultaneously observe dynamic and static structures at the nano and atomic scales, and also induce structural rearrangements and chemical transformation. The addition of predictive modeling or rapid image analytics and feedback enables guiding these in a controlled manner. Here, we review the recent results that used focused electron and ion beams to create free-standing nanoscale 3D structures, radiolysis and the fabrication potential with liquid precursors, epitaxial crystallization of amorphous oxides with atomic layer precision, as well as visualization and control of individual dopant motion within a 3D crystal lattice. These works lay the foundation for new approaches to directing nanoscale level architectures and offer a potential roadmap to full 3D atomic control in materials. Lastly, in this perspective we lay out the gaps that currently constrain the processing range of these platforms, reflect on indirect requirements, such as the integration of large scale data analysis with theory, and discuss future prospects of these technologies.« less

  13. Directing Matter: Towards Atomic Scale 3D Nanofabrication

    DOE PAGESBeta

    Jesse, Stephen; Borisevich, Albina Y; Fowlkes, Jason Davidson; Lupini, Andrew R; Rack, Philip D; Unocic, Raymond R; Sumpter, Bobby G; Kalinin, Sergei V; Ovchinnikova, Olga S

    2016-01-01

    Enabling memristive, neuromorphic, and quantum based computing as well as efficient mainstream energy storage and conversion technologies requires next generation of materials customized at the atomic scale. This requires full control of atomic arrangement and bonding in three dimensions. The last two decades witnessed substantial industrial, academic, and government research efforts directed towards this goal through various lithographies and scanning probe based methods. These technologies emphasize 2D surface structures, with some limited 3D capability. Recently, a range of focused electron and ion based methods have demonstrated compelling alternative pathways to achieving atomically precise manufacturing of 3D structures in solids, liquids,more » and at interfaces. Electron and ion microscopies offer a platform that can simultaneously observe dynamic and static structures at the nano and atomic scales, and also induce structural rearrangements and chemical transformation. The addition of predictive modeling or rapid image analytics and feedback enables guiding these in a controlled manner. Here, we review the recent results that used focused electron and ion beams to create free-standing nanoscale 3D structures, radiolysis and the fabrication potential with liquid precursors, epitaxial crystallization of amorphous oxides with atomic layer precision, as well as visualization and control of individual dopant motion within a 3D crystal lattice. These works lay the foundation for new approaches to directing nanoscale level architectures and offer a potential roadmap to full 3D atomic control in materials. In this perspective we lay out the gaps that currently constrain the processing range of these platforms, reflect on indirect requirements, such as the integration of large scale data analysis with theory, and discuss future prospects of these technologies.« less

  14. DNA-templated lithography and nanofabrication for the fabrication of nanoscale electronic circuitry.

    PubMed

    Gates, Elisabeth P; Dearden, Andrew M; Woolley, Adam T

    2014-01-01

    The field of structural DNA nanotechnology has undergone significant expansion in recent years as exciting new techniques and understanding have been developed, allowing for the design and assembly of complex and intricate two- and three-dimensional nanostructures. Many of these designed DNA motifs have found use in precise positioning of nanomaterials and thereby can aid in studies, reactions, and assembly of other nanostructures. This review discusses the history and progression of DNA-based nanofabrication with an emphasis on the use of DNA nanostructures for electronics applications. PMID:25391721

  15. Template-free electrochemical nanofabrication of polyaniline nanobrush and hybrid polyaniline with carbon nanohorns for supercapacitors

    NASA Astrophysics Data System (ADS)

    Wei, Di; Wang, Haolan; Hiralal, Pritesh; Andrew, Piers; Ryhänen, Tapani; Hayashi, Yasuhiko; Amaratunga, Gehan A. J.

    2010-10-01

    Polyaniline (PANI) nanobrushes were synthesized by template-free electrochemical galvanostatic methods. When the same method was applied to the carbon nanohorn (CNH) solution containing aniline monomers, a hybrid nanostructure containing PANI and CNHs was enabled after electropolymerization. This is the first report on the template-free method to make PANI nanobrushes and homogeneous hybrid soft matter (PANI) with carbon nanoparticles. Raman spectroscopy was used to analyze the interaction between CNH and PANI. Electrochemical nanofabrication offers simplicity and good control when used to make electronic devices. Both of these materials were applied in supercapacitors and an improvement capacitive current by using the hybrid material was observed.

  16. Template-free electrochemical nanofabrication of polyaniline nanobrush and hybrid polyaniline with carbon nanohorns for supercapacitors.

    PubMed

    Wei, Di; Wang, Haolan; Hiralal, Pritesh; Andrew, Piers; Ryhänen, Tapani; Hayashi, Yasuhiko; Amaratunga, Gehan A J

    2010-10-29

    Polyaniline (PANI) nanobrushes were synthesized by template-free electrochemical galvanostatic methods. When the same method was applied to the carbon nanohorn (CNH) solution containing aniline monomers, a hybrid nanostructure containing PANI and CNHs was enabled after electropolymerization. This is the first report on the template-free method to make PANI nanobrushes and homogeneous hybrid soft matter (PANI) with carbon nanoparticles. Raman spectroscopy was used to analyze the interaction between CNH and PANI. Electrochemical nanofabrication offers simplicity and good control when used to make electronic devices. Both of these materials were applied in supercapacitors and an improvement capacitive current by using the hybrid material was observed. PMID:20876981

  17. Enzymatic activity induced by interactions with a nanofabricated hydrophobic Si surface

    NASA Astrophysics Data System (ADS)

    Nishiyama, Katsuhiko

    2013-07-01

    The binding of peptides of 2-10 glycine residues (2-10Gly) to papain on nanofabricated hydrophobic Si surfaces was investigated by molecular dynamics and docking simulations. 5Gly, 7Gly, 9Gly, and 10Gly were distributed on sites near the active center of papain on the Si surface, while 6-10Gly were distributed on sites near the active center of free papain. The Si surface changed the substrate specificity of papain, and modification of this surface should allow full control of substrate specificity. Molecular surgery of proteins in cells may be realized using papain on specially designed surfaces.

  18. Compact Submillimeter-Wave Receivers Made with Semiconductor Nano-Fabrication Technologies

    NASA Technical Reports Server (NTRS)

    Jung, C.; Thomas, B.; Lee, C.; Peralta, A.; Chattopadhyay, G.; Gill, J.; Cooper, K.; Mehdi, I.

    2011-01-01

    Advanced semiconductor nanofabrication techniques are utilized to design, fabricate and demonstrate a super-compact, low-mass (<10 grams) submillimeter-wave heterodyne front-end. RF elements such as waveguides and channels are fabricated in a silicon wafer substrate using deep-reactive ion etching (DRIE). Etched patterns with sidewalls angles controlled with 1 deg precision are reported, while maintaining a surface roughness of better than 20 nm rms for the etched structures. This approach is being developed to build compact 2-D imaging arrays in the THz frequency range.

  19. Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization

    PubMed Central

    Palma, Matteo; Abramson, Justin; Gorodetsky, Alon; Nuckolls, Colin; Sheetz, Michael P.; Wind, Shalom J.; Hone, James

    2012-01-01

    Nanopatterned arrays of biomolecules are a powerful tool to address fundamental issues in many areas of biology. DNA nanoarrays, in particular, are of interest in the study of both DNA-protein interactions as well as for biodiagnostic investigations. In this context, achieving a highly specific nanoscale assembly of oligonulceotides at surfaces is critical. In this chapter we describe a method to control the immobilization of DNA on nanopatterned surfaces: the nanofabrication and the bio-functionalization involved in the process will be discussed. PMID:21674372

  20. Nanoscience and nanofabrication at Argonne National Laboratory: The art of making small

    NASA Astrophysics Data System (ADS)

    Ocola, Leonidas E.

    2014-03-01

    Over a decade ago the Department of Energy started the design, and construction of five Nanoscale Science Research Centers at different national laboratories with the objective to provide research opportunities in Nanoscience for the scientific community worldwide. The Center for Nanoscale Materials (CNM) at Argonne National Laboratory was constructed in 2006, and opened its doors to the user community in 2007. Currently the CNM hosts over 400 user proposals a year. There are six research groups at the CNM that do work in nanophotonics, electronic and magnetic materials and devices, nanobio interfaces, nanofabrication and devices, x-ray nanoscale microscopy and theory and modeling. I work in the Nanofabrication and Devices group and my research career has covered the use of x-rays, electrons and ions in the pursuit of making the smaller and smaller structures and devices. At the CNM I have been able to push the limits of electron beam lithography, and expand the use of ion beams to large area nanofabrication. Some of our accomplishments include determining liquid-polymer interactions as a function of temperature, redefining proximity effect correction at the nanoscale (NanoPEC), measuring to less than 0.5% error the backscatter range for 100 KV electron beams and finding that the range is a function of the density of the substrate, fabrication of plasmonic slit waveguides, and using ions to create complex three dimensional structures for use in fluidics. None of these accomplishments are possible without detailed understanding of the physics and chemistry mechanisms involved during fabrication. This requires extensive theory and simulation work to validate our experimental results. The fruit of our work then is a full understanding of ``why'' we use certain processes for nanofabrication and not just a simple set of process recipes. A summary of all these activities will be discussed at the presentation. This work was supported by the Department of Energy under

  1. Generation of Electron Bessel Beams with Nondiffractive Spreading by a Nanofabricated Annular Slit

    NASA Astrophysics Data System (ADS)

    Saitoh, Koh; Hirakawa, Kazuma; Nambu, Hiroki; Tanaka, Nobuo; Uchida, Masaya

    2016-04-01

    The shaping of a wavefront of free electrons has been experimentally realized very recently. We report the generation of an electron Bessel beam using a nanofabricated annular slit. We directly observe that electron Bessel beams propagate while maintaining a narrow beam width over a long propagation distance. In addition, we experimentally verify the self-healing property of these electron beams, which can reconstruct their shape after passing an obstacle. The experimental results are compared with simulation results of the propagation including a hexagonal slit. The present technique of electron Bessel beam generation can be used to develop a novel electron-beam-shaping, an atomic manipulation technique, and a new electron microscopy.

  2. Nanofabrication Towards Biomedical Applications: Techniques, Tools, Applications, and Impact

    NASA Astrophysics Data System (ADS)

    Kumar, Challa S. S. R.; Hormes, Josef; Leuschner, Carola

    2005-04-01

    This book focuses on the materials, synthetic methods, tools and techniques being developed in the nanoregime towards the life sciences -- in particular biology, biotechnology and medicine. Readers from materials science, engineering, chemistry, biology and medical backgrounds will find detailed accounts of the design and synthesis of nanomaterials and the tools and techniques involved in their production for applications in biology, biotechnology and medicine.

  3. Nano-fabricated pixelated micropolarizer array for visible imaging polarimetry

    SciTech Connect

    Zhang, Zhigang; Cheng, Teng; Qiu, Kang; Zhang, Qingchuan E-mail: wgchu@nanoctr.cn; Wu, Xiaoping; Dong, Fengliang; Chu, Weiguo E-mail: wgchu@nanoctr.cn

    2014-10-15

    Pixelated micropolarizer array (PMA) is a novel concept for real-time visible imaging polarimetry. A 320 × 240 aluminum PMA fabricated by electron beam lithography is described in this paper. The period, duty ratio, and depth of the grating are 140 nm, 0.5, and 100 nm, respectively. The units are standard square structures and the metal nanowires of the grating are collimating and uniformly thick. The extinction ratio of 75 and the maximum polarization transmittance of 78.8% demonstrate that the PMA is suitable for polarization imaging. When the PMA is applied to real-time polarization imaging, the degree of linear polarization image and the angle of linear polarization image are calculated from a single frame image. The polarized target object is highlighted from the unpolarized background, and the surface contour of the target object can be reflected by the polarization angle.

  4. Temperature-Dependent Nanofabrication on Silicon by Friction-Induced Selective Etching.

    PubMed

    Jin, Chenning; Yu, Bingjun; Xiao, Chen; Chen, Lei; Qian, Linmao

    2016-12-01

    Friction-induced selective etching provides a convenient and practical way for fabricating protrusive nanostructures. A further understanding of this method is very important for establishing a controllable nanofabrication process. In this study, the effect of etching temperature on the formation of protrusive hillocks and surface properties of the etched silicon surface was investigated. It is found that the height of the hillock produced by selective etching increases with the etching temperature before the collapse of the hillock. The temperature-dependent selective etching rate can be fitted well by the Arrhenius equation. The etching at higher temperature can cause rougher silicon surface with a little lower elastic modulus and hardness. The contact angle of the etched silicon surface decreases with the etching temperature. It is also noted that no obvious contamination can be detected on silicon surface after etching at different temperatures. As a result, the optimized condition for the selective etching was addressed. The present study provides a new insight into the control and application of friction-induced selective nanofabrication. PMID:27119157

  5. Soy-Protein-Based Nanofabrics for Highly Efficient and Multifunctional Air Filtration.

    PubMed

    Souzandeh, Hamid; Johnson, Kyle S; Wang, Yu; Bhamidipaty, Keshava; Zhong, Wei-Hong

    2016-08-10

    Proteins are well-known by their numerous active functional groups along the polypeptide chain. The variety of functional groups of proteins provides a great potential for proteins to interact with airborne pollutants with varying surface properties. However, to our knowledge, a successful demonstration of this potential has not been reported before. In this work, soy protein, a type of abundant plant protein, has been employed for the first time to fabricate multifunctional air-filtration materials. To take advantage of the functional groups of soy protein for air filtration, the soy protein was first well denatured to unfold the polypeptide chains and then fabricated into nanofibers with the help of poly(vinyl alcohol). It was found that the resultant nanofabrics showed high filtration efficiency not only for airborne particulates with a broad range of size but also for various toxic gaseous chemicals (e.g., formaldehyde and carbon monoxide), a capability that has not been realized by conventional air-filtering materials. This study indicates that protein-based nanofabrics are promising nanomaterials for multifunctional air-filtration applications. PMID:27439677

  6. Reduced thermal quadrupole heat transport modeling in harmonic and transient regime scanning thermal microscopy using nanofabricated thermal probes

    NASA Astrophysics Data System (ADS)

    Bodzenta, J.; Chirtoc, M.; Juszczyk, J.

    2014-08-01

    The thermal model of a nanofabricated thermal probe (NTP) used in scanning thermal microscopy is proposed. It is based on consideration of the heat exchange channels between electrically heated probe, a sample, and their surroundings, in transient and harmonic regimes. Three zones in the probe-sample system were distinguished and modeled by using electrical analogies of heat flow through a chain of quadrupoles built from thermal resistances and thermal capacitances. The analytical transfer functions for two- and three-cell quadrupoles are derived. A reduced thermal quadrupole with merged RC elements allows for thermo-electrical modeling of the complex architecture of a NTP, with a minimum of independent parameters (two resistance ratios and two time constants). The validity of the model is examined by comparing computed values of discrete RC elements with results of finite element simulations and with experimental data. It is proved that the model consisting of two or three-cell quadrupole is sufficient for accurate interpretation of experimental results. The bandwidth of the NTP is limited to 10 kHz. The performance in dc regime can be simply obtained in the limit of zero frequency. One concludes that the low NTP sensitivity to sample thermal conductivity is due, much like in dc regime, to significant heat by-pass by conduction through the cantilever, and to the presence of probe-sample contact resistance in series with the sample.

  7. Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.

    PubMed

    Mallapragada, Surya K; Brenza, Timothy M; McMillan, JoEllyn M; Narasimhan, Balaji; Sakaguchi, Donald S; Sharma, Anup D; Zbarska, Svitlana; Gendelman, Howard E

    2015-04-01

    Nanoparticulate delivery systems represent an area of particular promise for nanoneuromedicines. They possess significant potential for desperately needed therapies designed to combat a range of disorders associated with aging. As such, the field was selected as the focus for the 2014 meeting of the American Society for Nanomedicine. Regenerative, protective, immune modulatory, anti-microbial and anti-inflammatory products, or imaging agents are readily encapsulated in or conjugated to nanoparticles and as such facilitate the delivery of drug payloads to specific action sites across the blood-brain barrier. Diagnostic imaging serves to precisely monitor disease onset and progression while neural stem cell replacement can regenerate damaged tissue through control of stem cell fates. These, taken together, can improve disease burden and limit systemic toxicities. Such enabling technologies serve to protect the nervous system against a broad range of degenerative, traumatic, metabolic, infectious and immune disorders. From the clinical editor: Nanoneuromedicine is a branch of nanomedicine that specifically looks at the nervous system. In the clinical setting, a fundamental hurdle in nervous system disorders is due to an inherent inability of nerve cells to regenerate after damage. Nanotechnology can offer new approaches to overcome these challenges. This review describes recent developments in nanomedicine delivery systems that would affect stem cell repair and regeneration in the nervous system. PMID:25652894

  8. Nanowicking: Multi-Scale Flow Interaction with Nanofabric Structures

    NASA Astrophysics Data System (ADS)

    Zhou, Jijie

    Dense arrays of aligned carbon nanotubes are designed into strips --- nanowicks --- as a miniature wicking element for liquid delivery and potential microfluidic chemical analysis devices. The delivery function of nanowicks enables novel fluid transport devices to run without any power input, moving parts or external pump. The intrinsically nanofibrous structure of nanowicks provides a sieving matrix for molecular separations, and a high surface-to-volume ratio porous bed to carry catalysts or reactive agents. This work also experimentally studies the spontaneous fluid transport along nanowicks. Liquid is conveyed through corner flow, surface flow, and interstitial flow through capillary force and the Marangoni effect. The main course for corner flow and surface flow follows Washburn behavior, and can deliver liquid centimeters away from the input blob with a speed on the order of millimeters per second depending on the nanowick configuration and the amount of input liquid. Corner flow can be minimized and even eliminated through proper nanowick and input design. Otherwise, corner flow interacts with surface flow in the first 2mm of the pathway closest to the input point. Interstitial flow dominates the late stage. It is driven by both capillary force and concentration-gradient-induced Marangoni force. The concentration gradient is determined by two competing rates: surfactant diffusion in solution and adsorption onto nanotube surfaces. The flow inside nanowicks may wick hundreds of microns in seconds or tens of seconds. A non-conventional advancing front may develop in the flow around nanowicks. They are seen as (i) Rayleigh instability-induced fingering in surface flow on millimeter-wide nanowicks, (ii) viscous instability-induced branching near almost-stagnant surface film at low surfactant concentration, and (iii) disjointed wetting domains at very low concentration.

  9. Shape-programmed nanofabrication: understanding the reactivity of dichalcogenide precursors.

    PubMed

    Guo, Yijun; Alvarado, Samuel R; Barclay, Joshua D; Vela, Javier

    2013-04-23

    Dialkyl and diaryl dichalcogenides are highly versatile and modular precursors for the synthesis of colloidal chalcogenide nanocrystals. We have used a series of commercially available dichalcogenide precursors to unveil the molecular basis for the outcome of nanocrystal preparations, more specifically, how precursor molecular structure and reactivity affect the final shape and size of II-VI semiconductor nanocrystals. Dichalcogenide precursors used were diallyl, dibenzyl, di-tert-butyl, diisopropyl, diethyl, dimethyl, and diphenyl disulfides and diethyl, dimethyl, and diphenyl diselenides. We find that the presence of two distinctively reactive C-E and E-E bonds makes the chemistry of these precursors much richer and interesting than that of other conventional precursors such as the more common phosphine chalcogenides. Computational studies (DFT) reveal that the dissociation energy of carbon-chalcogen (C-E) bonds in dichalcogenide precursors (R-E-E-R, E=S or Se) increases in the order (R): diallylfrom dots to pods to tetrapods. Under identical experimental conditions, we obtain CdS and CdSe nanocrystals with spherical, elongated, or tetrapodal morphology by simply varying the identity and reactivity of the dichalcogenide precursor. Interestingly, we find that precursors with strong C-E and weak E-E bond dissociation energies such as Ph-S-S-Ph serve as a ready source of thiol radicals that appear to stabilize small CdE nuclei, facilitating anisotropic growth. These CdS and CdSe nanocrystals have been

  10. Enabling Desktop Nanofabrication with the Targeted Use of Soft Materials

    NASA Astrophysics Data System (ADS)

    Eichelsdoerfer, Daniel James

    with a simple chemical change to the composition of the elastomer. In particular, the extent of cross-linking within the elastomer is found to dictate the k the backing layer, and arrays with spring constants tuned from 7 to 150 N/m are described. Furthermore, a simple geometric model is developed that explains the low variation of k within each cantilever-free array; this stands in contrast to arrays of cantilevers, which typically show large variations of k within an array. Chapter 4 addresses the problem of individual actuation in SPL by embedding resistive heaters directly beneath the elastomeric backing layer. This actuation scheme was chosen because the elastomer used in the cantilever-free tip arrays has extraordinary thermal expansion properties, and thorough exploration of their actuation behavior shows that the heater arrays are fast (> 100 microm/s) and powerful (> 4 microm) enough for actuation. After implementing several corrections for the tip height -- a problem that is intractable without the heaters, and has never been addressed before -- printing of alkanethiols onto Au is demonstrated with a 2D array of individually actuated probes. Chapter 5 examines the hypothesis that elastomeric tips can absorb solvent and be used to transport materials in the absence of environmental solvent. This is evaluated by first using tip arrays soaked in a nonpolar solvent to pattern a hydrophobic block copolymer that cannot be patterned by traditional DPN, and is subsequently explored for the case of water uptake into the pen arrays. Surprisingly, despite their poor water retention ability, the tip arrays can store enough water to pattern hydrophilic polymers in dry environments for over 2 hours. The dynamics of the solvent absorption are captured by a simple calculation that accounts for the dynamical behavior of water retention and the backing layer thickness, thereby allowing these results to be generalized to other solvents. This exploration of the subtle and

  11. Aerotactile Integration from Distal Skin Stimuli

    PubMed Central

    Derrick, Donald; Gick, Bryan

    2015-01-01

    Tactile sensations at extreme distal body locations can integrate with auditory information to alter speech perception among uninformed and untrained listeners. Inaudible air puffs were applied to participants' ankles, simultaneously with audible syllables having aspirated and unaspirated stop onsets. Syllables heard simultaneously with air puffs were more likely to be heard as aspirated. These results demonstrate that event-appropriate information from distal parts of the body integrates in speech perception, even without frequent or robust location-specific experience. In addition, overall performance was significantly better for those with hair on their ankles, which suggests that the presence of hair may help establish signal relevance, and so aid in multi-modal speech perception. PMID:24649526

  12. Thermodynamic integration from classical to quantum mechanics

    SciTech Connect

    Habershon, Scott; Manolopoulos, David E.

    2011-12-14

    We present a new method for calculating quantum mechanical corrections to classical free energies, based on thermodynamic integration from classical to quantum mechanics. In contrast to previous methods, our method is numerically stable even in the presence of strong quantum delocalization. We first illustrate the method and its relationship to a well-established method with an analysis of a one-dimensional harmonic oscillator. We then show that our method can be used to calculate the quantum mechanical contributions to the free energies of ice and water for a flexible water model, a problem for which the established method is unstable.

  13. Determination of the number of atoms present in nano contact based on shot noise measurements with highly stable nano-fabricated electrodes.

    PubMed

    Takahashi, Ryoji; Kaneko, Satoshi; Marqués-González, Santiago; Fujii, Shintaro; Nishino, Tomoaki; Tsukagoshi, Kazuhito; Kiguchi, Manabu

    2016-07-22

    A highly stable experimental setup was developed for the measurement of shot noise in atomic contacts and molecular junctions to determine the number of atoms or molecules present. The use of a nano-fabricated mechanically controllable break junction (MCBJ) electrode improved the overall stability of the experimental setup. The improved stability of the system and optimization of measurement system enabled us to comprehensively investigate the shot noise as well as charge transport properties in Au atomic contacts and molecular junctions. We present a solid proof that the number of atoms (cross sectional atom) in the Au atomic contacts was exactly one. In the atomic contacts, contribution from the additional channels was under the detection limit. Furthermore, the effect of molecular adsorption on the charge transport in the Au atomic contact was investigated. Additional transport channels were opened by exposing pyrazine molecules to the Au contacts, which gave rise to an increase in the Fano factor in the shot noise. PMID:27291763

  14. Determination of the number of atoms present in nano contact based on shot noise measurements with highly stable nano-fabricated electrodes

    NASA Astrophysics Data System (ADS)

    Takahashi, Ryoji; Kaneko, Satoshi; Marqués-González, Santiago; Fujii, Shintaro; Nishino, Tomoaki; Tsukagoshi, Kazuhito; Kiguchi, Manabu

    2016-07-01

    A highly stable experimental setup was developed for the measurement of shot noise in atomic contacts and molecular junctions to determine the number of atoms or molecules present. The use of a nano-fabricated mechanically controllable break junction (MCBJ) electrode improved the overall stability of the experimental setup. The improved stability of the system and optimization of measurement system enabled us to comprehensively investigate the shot noise as well as charge transport properties in Au atomic contacts and molecular junctions. We present a solid proof that the number of atoms (cross sectional atom) in the Au atomic contacts was exactly one. In the atomic contacts, contribution from the additional channels was under the detection limit. Furthermore, the effect of molecular adsorption on the charge transport in the Au atomic contact was investigated. Additional transport channels were opened by exposing pyrazine molecules to the Au contacts, which gave rise to an increase in the Fano factor in the shot noise.

  15. Micro/nanofabrication of poly(L-lactic acid) using focused ion beam direct etching

    NASA Astrophysics Data System (ADS)

    Oyama, Tomoko Gowa; Hinata, Toru; Nagasawa, Naotsugu; Oshima, Akihiro; Washio, Masakazu; Tagawa, Seiichi; Taguchi, Mitsumasa

    2013-10-01

    Micro/nanofabrication of biocompatible and biodegradable poly(L-lactic acid) (PLLA) using focused Ga ion beam direct etching was evaluated for future bio-device applications. The fabrication performance was determined with different ion fluences and fluxes (beam currents), and it was found that the etching speed and fabrication accuracy were affected by irradiation-induced heat. Focused ion beam (FIB)-irradiated surfaces were analyzed using micro-area X-ray photoelectron spectroscopy. Owing to reactions such as the physical sputtering of atoms and radiation-induced decomposition, PLLA was gradually carbonized with increasing C=C bonds. Controlled micro/nanostructures of PLLA were fabricated with C=C bond-rich surfaces expected to have good cell attachment properties.

  16. Integrated photonics

    NASA Astrophysics Data System (ADS)

    Gondarenko, Alexander A.

    In 1958 the first integrated circuit was demonstrated to combine transistors, resistors, and capacitors [36]. To this date fabrication technology has been driven by the growing demand for monolithically constructed, densely packed electronic components. The exponentially shrinking device size decreased the feature dimensions from 10 microns to 32 nm and grew transistor count from 2,300 to over 2,000,000,000 in Intel's 4004 and Intel Kentsfield XE microprocessors. The benefits of micro- and nano-fabrication was not limited to just computer chips. MEMs, spintronic, microfluidics, and integrated photonics were all made possible by the ever expanding ability to form complex geometries, on a wide variety of materials, on a micron and submicron scale. This dissertation is part of an effort to design and fabricate novel integrated photonic devices compatible with standard electron beam and photo lithography and utilize a readily available material base. We aim to create devices with a decreased footprint on a chip and operate in the infrared, visible, and UV spectra. We present two general sections, the first is a theoretical effort to find the fundamental design geometries for a variety of optical problems. The second section is an experimental demonstration of techniques and devices for novel optical phenomena in an integrated package. In the theoretical section we develop and apply computational evolutionary algorithms to explore problems of light confinement, coupling, and guiding in two and three dimensional device geometries. Our general aim is to find a global limit to optimal device geometry and performance given a set of constrains. Experimentally, we demonstrate an efficient design and a fabrication process for a short development cycle of photonic devices. For the design part of the workflow, we develop a computational approach to explore device geometries with minimum initial assumptions for a variety of photonic problems. For the fabrication part of the

  17. Thermomechanically integrated distillation of ethylene from ethane

    SciTech Connect

    Greene, D.G.; Haddad, H.; Manley, D.B.

    1994-12-31

    The separation of ethylene from ethane by distillation is normally the final step in the production of ethylene. The critical temperature of ethylene is about 50 F, therefore moderately low temperatures and moderately high pressures are typically used to provide optimum economic conditions. The optimum design can require thick walled and heavy pressure vessels which may be constructed of expensive alloy steels depending on the specific operating conditions. The required purity of ethylene usually exceeds 99.9%, and the economic level of recovery is approximately 99%. In addition, the relative volatility of ethylene to ethane is moderately small ranging from about 1.13 for high pressure mixtures rich in ethylene to 2.34 for low pressure mixtures rich in ethane. The relatively high purity and recovery and relatively low relative volatility dictate a large distillation column with more than 100 trays and a large diameter for world scale production levels of over a billion pounds per year of ethylene. The installed capital cost for a unit of this type and size can exceed twenty million dollars, and utility costs can exceed one million dollars per year. Consequently, there is a strong economic incentive to reduce costs through improved process designs for the distillation of ethylene from ethane, and the process is well studied in the literature. Thermomechanically integrated distillation provides an improved design which can reduce both capital and operating costs as compared to the best conventional designs. In this paper, the conventional designs for both vapor and liquid feeds are reviewed, the underlying thermodynamics characterizing the process is discussed, alternative thermomechanically integrated designs are presented, and utility and purchased equipment costs are compared.

  18. Sustainable NREL: From Integration to Innovation

    SciTech Connect

    2015-09-01

    NREL's sustainability practices are integrated throughout the laboratory and are essential to our mission to develop clean energy and energy efficiency technologies and practices, advance related science and engineering, and provide knowledge and innovations to integrate energy systems at all scales. Sustainability initiatives are integrated through our campus, our staff, and our environment allowing NREL to provide leadership in modeling a sustainability energy future for companies, organizations, governments, and communities.

  19. High aspect ratio nano-fabrication of photonic crystal structures on glass wafers using chrome as hard mask

    NASA Astrophysics Data System (ADS)

    Nazmul Hossain, Md; Justice, John; Lovera, Pierre; McCarthy, Brendan; O'Riordan, Alan; Corbett, Brian

    2014-09-01

    Wafer-scale nano-fabrication of silicon nitride (Si x N y ) photonic crystal (PhC) structures on glass (quartz) substrates is demonstrated using a thin (30 nm) chromium (Cr) layer as the hard mask for transferring the electron beam lithography (EBL) defined resist patterns. The use of the thin Cr layer not only solves the charging effect during the EBL on the insulating substrate, but also facilitates high aspect ratio PhCs by acting as a hard mask while deep etching into the Si x N y . A very high aspect ratio of 10:1 on a 60 nm wide grating structure has been achieved while preserving the quality of the flat top of the narrow lines. The presented nano-fabrication method provides PhC structures necessary for a high quality optical response. Finally, we fabricated a refractive index based PhC sensor which shows a sensitivity of 185 nm per RIU.

  20. Development of nano-fabrication technique utilizing self-organizational behavior of point defects induced by ion irradiation

    NASA Astrophysics Data System (ADS)

    Nitta, Noriko; Taniwaki, Masafumi

    2006-04-01

    The present authors proposed a novel nano-fabrication technique that is able to arrange the fine cells orderly, based on their finding in GaSb implanted at a low temperature. In this article, first the experimental results that anomalous cellular structure was formed in GaSb by ion implantation is introduced and the self-organizational formation mechanism of the structure is described. Next a nano-fabrication technique that utilizes focused ion beam is described. This technique consists of two procedures, i.e. the formation process of the voids array and the development of the initial array to ordered cellular structure. Finally, the nano-fabrication is actually performed by this technique and their results are reported. Fabrication succeeded in structures where the dot (cell) interval was 100 nm or larger. The minimum ion dose for initial voids which develops to the ordered cellular structure is evaluated. It is also shown that the substrate temperature during implantation is an essential parameter for this technique.

  1. Extracting Data From Integrated Student Information Systems.

    ERIC Educational Resources Information Center

    Yost, Michael

    An integrated student information system (ISIS) at Trinity University (Texas) is described with attention to how data are entered and how data are extracted for purposes of institutional research. The structure of the original ISIS files, the extract files, and the Statistical Package for the Social Sciences (SPSS) files is examined. An outline is…

  2. High-throughput nanofabrication of infrared plasmonic nanoantenna arrays for vibrational nanospectroscopy.

    PubMed

    Aksu, Serap; Yanik, Ahmet A; Adato, Ronen; Artar, Alp; Huang, Min; Altug, Hatice

    2010-07-14

    The introduction of high-throughput and high-resolution nanofabrication techniques operating at low cost and low complexity is essential for the advancement of nanoplasmonic and nanophotonic fields. In this paper, we demonstrate a novel fabrication approach based on nanostencil lithography for high-throughput fabrication of engineered infrared plasmonic nanorod antenna arrays. The technique relying on deposition of materials through a shadow mask enables plasmonic substrates supporting spectrally sharp collective resonances. We show that reflectance spectra of these antenna arrays are comparable to that of arrays fabricated by electron beam lithography. We also show that nanostencils can be reused multiple times to fabricate a series of infrared nanoantenna arrays with identical optical responses. Finally, we demonstrate fabrication of plasmonic nanostructures in a variety of shapes with a single metal deposition step on different substrates, including nonconducting ones. Our approach, by enabling the reusability of the stencil and offering flexibility on the substrate choice and nanopattern design, could facilitate the transition of plasmonic technologies to the real-world applications. PMID:20560536

  3. Nanofabrication of high aspect ratio structures using an evaporated resist containing metal

    NASA Astrophysics Data System (ADS)

    Con, Celal; Zhang, Jian; Cui, Bo

    2014-05-01

    Organic electron beam resists are typically not resistant to the plasma etching employed to transfer the pattern into the underlying layer. Here, the authors present the incorporation of a metal hard mask material into negative resist polystyrene by co-evaporation of the polystyrene and the metal onto a substrate. With a volume ratio of 1:15 between Cr and polystyrene, this nanocomposite resist showed an etching selectivity to silicon one order higher than pure polystyrene resist. Silicon structures of 100 nm width and 3.5 μm height (aspect ratio 1:35) were obtained using a non-switching deep silicon etching recipe with SF6 and C4F8 gas. Moreover, unlike the common spin coating method, evaporated nanocomposite resist can be coated onto irregular and non-flat surfaces such as optical fibers and AFM cantilevers. As a proof of concept, we fabricated high aspect ratio structures on top of an AFM cantilever. Nanofabrication on non-flat surfaces may find applications in the fields of (AFM) tip enhanced Raman spectroscopy for chemical analysis and lab-on-fiber technology.

  4. Nondestructive nanofabrication on Si(100) surface by tribochemistry-induced selective etching.

    PubMed

    Guo, Jian; Yu, Bingjun; Chen, Lei; Qian, Linmao

    2015-01-01

    A tribochemistry-induced selective etching approach is proposed for the first time to produce silicon nanostructures without lattice damage. With a ~1 nm thick SiOx film as etching mask grown on Si(100) surface (Si(100)/SiOx) by wet-oxidation technique, nano-trenches can be produced through the removal of local SiOx mask by a SiO2 tip in humid air and the post-etching of the exposed Si in potassium hydroxide (KOH) solution. The material removal of SiOx mask and Si under low load is dominated by the tribochemical reaction at the interface between SiO2 tip and Si/SiOx sample, where the contact pressure is much lower than the critical pressure for initial yield of Si. High resolution transmission electron microscope (HRTEM) observation indicates that neither the material removal induced by tribochemical reaction nor the wet etching in KOH solution leads to lattice damage of the fabricated nanostructures. The proposed approach points out a new route in nondestructive nanofabrication. PMID:26559014

  5. Nondestructive nanofabrication on Si(100) surface by tribochemistry-induced selective etching

    PubMed Central

    Guo, Jian; Yu, Bingjun; Chen, Lei; Qian, Linmao

    2015-01-01

    A tribochemistry-induced selective etching approach is proposed for the first time to produce silicon nanostructures without lattice damage. With a ~1 nm thick SiOx film as etching mask grown on Si(100) surface (Si(100)/SiOx) by wet-oxidation technique, nano-trenches can be produced through the removal of local SiOx mask by a SiO2 tip in humid air and the post-etching of the exposed Si in potassium hydroxide (KOH) solution. The material removal of SiOx mask and Si under low load is dominated by the tribochemical reaction at the interface between SiO2 tip and Si/SiOx sample, where the contact pressure is much lower than the critical pressure for initial yield of Si. High resolution transmission electron microscope (HRTEM) observation indicates that neither the material removal induced by tribochemical reaction nor the wet etching in KOH solution leads to lattice damage of the fabricated nanostructures. The proposed approach points out a new route in nondestructive nanofabrication. PMID:26559014

  6. Nanofabrication of high aspect ratio structures using an evaporated resist containing metal.

    PubMed

    Con, Celal; Zhang, Jian; Cui, Bo

    2014-05-01

    Organic electron beam resists are typically not resistant to the plasma etching employed to transfer the pattern into the underlying layer. Here, the authors present the incorporation of a metal hard mask material into negative resist polystyrene by co-evaporation of the polystyrene and the metal onto a substrate. With a volume ratio of 1:15 between Cr and polystyrene, this nanocomposite resist showed an etching selectivity to silicon one order higher than pure polystyrene resist. Silicon structures of 100 nm width and 3.5 μm height (aspect ratio 1:35) were obtained using a non-switching deep silicon etching recipe with SF6 and C4F8 gas. Moreover, unlike the common spin coating method, evaporated nanocomposite resist can be coated onto irregular and non-flat surfaces such as optical fibers and AFM cantilevers. As a proof of concept, we fabricated high aspect ratio structures on top of an AFM cantilever. Nanofabrication on non-flat surfaces may find applications in the fields of (AFM) tip enhanced Raman spectroscopy for chemical analysis and lab-on-fiber technology. PMID:24717720

  7. Nondestructive nanofabrication on Si(100) surface by tribochemistry-induced selective etching

    NASA Astrophysics Data System (ADS)

    Guo, Jian; Yu, Bingjun; Chen, Lei; Qian, Linmao

    2015-11-01

    A tribochemistry-induced selective etching approach is proposed for the first time to produce silicon nanostructures without lattice damage. With a ~1 nm thick SiOx film as etching mask grown on Si(100) surface (Si(100)/SiOx) by wet-oxidation technique, nano-trenches can be produced through the removal of local SiOx mask by a SiO2 tip in humid air and the post-etching of the exposed Si in potassium hydroxide (KOH) solution. The material removal of SiOx mask and Si under low load is dominated by the tribochemical reaction at the interface between SiO2 tip and Si/SiOx sample, where the contact pressure is much lower than the critical pressure for initial yield of Si. High resolution transmission electron microscope (HRTEM) observation indicates that neither the material removal induced by tribochemical reaction nor the wet etching in KOH solution leads to lattice damage of the fabricated nanostructures. The proposed approach points out a new route in nondestructive nanofabrication.

  8. Nanofabrication on monocrystalline silicon through friction-induced selective etching of Si3N4 mask

    PubMed Central

    2014-01-01

    A new fabrication method is proposed to produce nanostructures on monocrystalline silicon based on the friction-induced selective etching of its Si3N4 mask. With low-pressure chemical vapor deposition (LPCVD) Si3N4 film as etching mask on Si(100) surface, the fabrication can be realized by nanoscratching on the Si3N4 mask and post-etching in hydrofluoric acid (HF) and potassium hydroxide (KOH) solution in sequence. Scanning Auger nanoprobe analysis indicated that the HF solution could selectively etch the scratched Si3N4 mask and then provide the gap for post-etching of silicon substrate in KOH solution. Experimental results suggested that the fabrication depth increased with the increase of the scratching load or KOH etching period. Because of the excellent masking ability of the Si3N4 film, the maximum fabrication depth of nanostructure on silicon can reach several microns. Compared to the traditional friction-induced selective etching technique, the present method can fabricate structures with lesser damage and deeper depths. Since the proposed method has been demonstrated to be a less destructive and flexible way to fabricate a large-area texture structure, it will provide new opportunities for Si-based nanofabrication. PMID:24940174

  9. Laser 3D micro/nanofabrication of polymers for tissue engineering applications

    NASA Astrophysics Data System (ADS)

    Danilevičius, P.; Rekštytė, S.; Balčiūnas, E.; Kraniauskas, A.; Širmenis, R.; Baltriukienė, D.; Bukelskienė, V.; Gadonas, R.; Sirvydis, V.; Piskarskas, A.; Malinauskas, M.

    2013-02-01

    In this work, we applied a constructed multi-photon polymerization system based on diode-pumped solid state femtosecond Yb:KGW laser used as pulsed irradiation light source (300 fs, 1030 nm, 200 kHz) in combination with large area high sample translation velocity (up to 300 mm/s) linear motor-driven stages (100×100×50 mm3) designed for high resolution and throughput 3D micro/nanofabrication. It enables rapid prototyping out of most polymers up to cm in scale with sub-micrometer spatial resolution. This can be used for production of three-dimensional artificial polymeric scaffolds applied for cell growth and expansion experiments as well as tissue engineering. Biocompatibilities of different acrylate, hybrid organic-inorganic and biodegradable polymeric materials were evaluated experimentally in vitro. Various in size and form scaffolds of biocompatible photopolymers were successfully fabricated having intricate 3D geometry, thus demonstrating the potential of the applied method. Adult rabbit myogenic stem cell proliferation tests show artificial scaffolds to be applicable for biomedical practice. Additionally, a micromolding technique was used for a rapid multiplication of adequate laser manufactured structures.

  10. Laser-Micro/Nanofabricated 3D Polymers for Tissue Engineering Applications

    NASA Astrophysics Data System (ADS)

    Danilevičius, P.; Žukauskas, A.; Bičkauskaitė, G.; Purlys, V.; Rutkauskas, M.; Gertus, T.; Paipulas, D.; Matukaitė, J.; Baltriukienė, D.; Malinauskas, M.

    2011-01-01

    A multi-photon polymerization system has been designed based on a pulsed irradiation light source (diode-pumped solid state femtosecond laser Yb:KGW, 300 fs, 1030 nm, 1-200 kHz) in combination with large working area and high precision linear motor driven stages (100×100×50 mm3). The system is intended for high resolution and throughput 3D micro- and nanofabrication and enables manufacturing the polymeric templates up to 1 cm2 areas with sub-micrometer resolution. These can be used for producing 3D artificial polymeric scaffolds to be applied for growing cells, specifically, in the tissue engineering. The bio-compatibility of different acrylate, hybrid organic-inorganic and biodegradable polymeric materials is evaluated experimentally in vitro. Variously sized and shaped polymeric scaffolds of biocompatible photopolymers with intricate 3D geometry were successfully fabricated. Proliferation tests for adult rabbit myogenic stem cells have shown the applicability of artificial scaffolds in biomedicine practice.

  11. Plasma-surface interactions for top-down and bottom-up nanofabrication

    NASA Astrophysics Data System (ADS)

    Ono, Kouichi

    2015-09-01

    Plasma processing is now widely employed for the fabrication of nanostructures in diverse fields of micro/nanoelectronic, optoelectronic, energy conversion, and sensing devices. The top-down plasma processes are indispensable in today's microelectronics industry, relying on the use of primarily anisotropic plasma etching following the lithography to define mask patterns; in some cases, self-assembled masks are served for the subsequent etching. The bottom-up ones are often employed to synthesize nanostructures such as nanotubes and nanowires, relying on the use of plasma enhanced chemical vapor deposition and plasma sputtering on self-assembled as well as lithographically formed patterns of metal catalysts. Moreover, the mask-less top-down approaches have recently been demonstrated to form nanopillars and periodic nanoripples, and the catalyst-free bottom-up approaches have been demonstrated to form nanowires. This talk is concerned with the current understanding and future prospects for plasma-surface interactions responsible for these top-down and bottom-up plasma nanofabrication processes, with attention placed on the fabrication of nanoscale fins and gates and also nanowires of silicon. On nanometer scale, ions and neutrals incident on surfaces are few in number during processing; thus, the nanoscale plasma-surface interactions concerned are stochastic, owing to the temporal as well as spatial uniformity of the incident flux and angle of them on surfaces being processed at nanoscale.

  12. Studying Teacher Selection of Resources in an Ultra-Large Scale Interactive System: Does Metadata Guide the Way?

    ERIC Educational Resources Information Center

    Abramovich, Samuel; Schunn, Christian

    2012-01-01

    Ultra-large-scale interactive systems on the Internet have begun to change how teachers prepare for instruction, particularly in regards to resource selection. Consequently, it is important to look at how teachers are currently selecting resources beyond content or keyword search. We conducted a two-part observational study of an existing popular…

  13. From multiple unitarity cuts to the coproduct of Feynman integrals

    NASA Astrophysics Data System (ADS)

    Abreu, Samuel; Britto, Ruth; Duhr, Claude; Gardi, Einan

    2014-10-01

    We develop techniques for computing and analyzing multiple unitarity cuts of Feynman integrals, and reconstructing the integral from these cuts. We study the relations among unitarity cuts of a Feynman integral computed via diagrammatic cutting rules, the discontinuity across the corresponding branch cut, and the coproduct of the integral. For single unitarity cuts, these relations are familiar. Here we show that they can be generalized to sequences of unitarity cuts in different channels. Using concrete one- and two-loop scalar integral examples we demonstrate that it is possible to reconstruct a Feynman integral from either single or double unitarity cuts. Our results offer insight into the analytic structure of Feynman integrals as well as a new approach to computing them.

  14. Integration and Task Allocation: Evidence from Patient Care*

    PubMed Central

    David, Guy; Rawley, Evan; Polsky, Daniel

    2013-01-01

    Using the universe of patient transitions from inpatient hospital care to skilled nursing facilities and home health care in 2005, we show how integration eliminates task misallocation problems between organizations. We find that vertical integration allows hospitals to shift patient recovery tasks downstream to lower-cost organizations by discharging patients earlier (and in poorer health) and increasing post-hospitalization service intensity. While integration facilitates a shift in the allocation of tasks and resources, health outcomes either improved or were unaffected by integration on average. The evidence suggests that integration solves coordination problems that arise in market exchange through improvements in the allocation of tasks across care settings. PMID:24415893

  15. Multidisciplinary integration in the context of integrated care - results from the North West London Integrated Care Pilot

    PubMed Central

    Harris, Matthew; Greaves, Felix; Gunn, Laura; Patterson, Sue; Greenfield, Geva; Car, Josip; Majeed, Azeem; Pappas, Yannis

    2013-01-01

    Background In the context of integrated care, Multidisciplinary Group meetings involve participants from diverse professional groups and organisations and are potential vehicles to advance efficiency improvements within the local health economy. We advance a novel method to characterise the communication within Multidisciplinary Group meetings measuring the extent to which participants integrate and whether this integration leads to improved working. Methods We purposively selected four Multidisciplinary Group meetings and conducted a content analysis of audio-recorded and transcribed Case Discussions. Two coders independently coded utterances according to their ‘integrative intensity’ which was defined against three a-priori independent domains - the Level (i.e. Individual, Collective and Systems); the Valence (Problem, Information and Solution); the Focus (Concrete and Abstract). Inter- and intra-rater reliability was tested with Kappa scores on one randomly selected Case Discussion. Standardised weighted mean integration scores were calculated for Case Discussions across utterance deciles, indicating how integrative intensity changed during the conversations. Results Twenty-three Case Discussions in four different Multidisciplinary Groups were transcribed and coded. Inter- and intra-rater reliability was good as shown by the Prevalence and Bias-Adjusted Kappa Scores for one randomly selected Case Discussion. There were differences in the proportion of utterances per participant type (Consultant 14.6%; presenting general practitioner 38.75%; Chair 7.8%; non-presenting general practitioner 2.25%; Allied Health Professional 4.8%). Utterances were predominantly coded at low levels of integrative intensity; however, there was a gradual increase (R 2 = 0.71) in integrative intensity during the Case Discussions. Based on the analysis of the minutes and action points arising from the Case Discussions, this improved integration did not translate into actions moving

  16. Integrating and amplifying signal from riboswitch biosensors.

    PubMed

    Goodson, Michael S; Harbaugh, Svetlana V; Chushak, Yaroslav G; Kelley-Loughnane, Nancy

    2015-01-01

    Biosensors offer a built-in energy supply and inherent sensing machinery that when exploited correctly may surpass traditional sensors. However, biosensor systems have been hindered by a narrow range of ligand detection capabilities, a relatively low signal output, and their inability to integrate multiple signals. Integration of signals could increase the specificity of the sensor and enable detection of a combination of ligands that may indicate environmental or developmental processes when detected together. Amplifying biosensor signal output will increase detector sensitivity and detection range. Riboswitches offer the potential to widen the diversity of ligands that may be detected, and advances in synthetic biology are illuminating myriad possibilities in signal processing using an orthogonal parts-based engineering approach. In this chapter, we describe the design, building, and testing of a riboswitch-based Boolean logic AND gate in bacteria, where an output requires the activation of two riboswitches, and the biological circuitry required to amplify the output of the AND gate using natural extracellular bacterial communication signals to "wire" cells together. PMID:25605381

  17. Phosphorus removal from secondary effluents through integrated constructed treatment system.

    PubMed

    Xiong, Jibing; Qin, Yong; Mahmood, Qaisar; Liu, Hanhu; Yang, Dejun

    2011-01-01

    The treatment capacity of an integrated constructed treatment system (CTS) was explored which was designed to reduce phosphorus (P) from secondary effluents. The integrated CTS was combined with vertical-flow constructed wetland, floating bed and sand filter. The vertical wetland was filled from the bottom to the top with gravels, steel slag and peat. Vetiverzizanioides (L.) Nash was selected to grow in the vertical constructed wetland while Coixlacrymajobi L. was grown in floating bed. The results suggested that integrated CTS displayed excellent removal efficiency for chemical oxygen demand (COD), dissolved phosphorus (DP), and total phosphorus (TP). The average COD removal efficiency of the integrated CTS was 90.45% after 40 days of operation, the average DP and TP removal efficiencies of the integrated CTS were 97.43% and 96.40%, respectively. The integrated CTS has good potential in removing COD as well as P from secondary effluents. PMID:21570097

  18. From clinical integration to accountable care.

    PubMed

    Shields, Mark

    2011-01-01

    Four key challenges to reforming health care organizations can be addressed by a clinical integration model patterned after Advocate Physician Partners (APP). These challenges are: predominance of small group practices, dominant fee-for-service reimbursement methods, weaknesses of the traditional hospital medical staff structure and a need to partner with commercial insurance companies. APP has demonstrated teamwork between 3800 physicians and hospitals to improve quality, patient safety and cost-effectiveness. Building on this model, an innovative contract with Blue Cross Blue Shield of Illinois serves as a prototype for a commercial Accountable Care Organization. For this contract to succeed, APP must outperform the market competition. To accomplish this, APP has implemented strategies to reduce readmissions, avoid unnecessary admissions and emergency room visits, expand primary care access, and enhance quality and patient safety. PMID:21910315

  19. The Effects of Tasks on Integrating Information from Multiple Documents

    ERIC Educational Resources Information Center

    Cerdan, Raquel; Vidal-Abarca, Eduardo

    2008-01-01

    The authors examine 2 issues: (a) how students integrate information from multiple scientific documents to describe and explain a physical phenomenon that represents a subset of the information in the documents; and (b) the role of 2 sorts of tasks to achieve this type of integration, either writing an essay on a question requiring integration…

  20. Toward Integration: From Quantitative Biology to Mathbio-Biomath?

    ERIC Educational Resources Information Center

    Marsteller, Pat; de Pillis, Lisette; Findley, Ann; Joplin, Karl; Pelesko, John; Nelson, Karen; Thompson, Katerina; Usher, David; Watkins, Joseph

    2010-01-01

    In response to the call of "BIO2010" for integrating quantitative skills into undergraduate biology education, 30 Howard Hughes Medical Institute (HHMI) Program Directors at the 2006 HHMI Program Directors Meeting established a consortium to investigate, implement, develop, and disseminate best practices resulting from the integration of math and…

  1. Spread Of Charge From Ion Tracks In Integrated Circuits

    NASA Technical Reports Server (NTRS)

    Zoutendyk, John A.; Schwartz, Harvey R.; Watson, R. Kevin; Nevill, Leland R.

    1989-01-01

    Single-event upsets (SEU's) propagate to adjacent cells in integrated memory circuits. Findings of experiments in lateral transport of electrical-charge carriers from ion tracks in 256K dynamic randon-access memories (DRAM's). As dimensions of integrated circuits decrease, vulnerability to SEU's increases. Understanding gained enables design of less vulnerable circuits.

  2. Li3V2(PO4)3 encapsulated flexible free-standing nanofabric cathodes for fast charging and long life-cycle lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Sun, Pingping; Zhao, Xueying; Chen, Renpeng; Chen, Tao; Ma, Lianbo; Fan, Qi; Lu, Hongling; Hu, Yi; Tie, Zuoxiu; Jin, Zhong; Xu, Qingyu; Liu, Jie

    2016-03-01

    Lithiated transition metal phosphates with large theoretical capacities have emerged as promising cathode materials for rechargeable lithium-ion batteries. However, the poor kinetic properties caused by their low intrinsic electronic and ionic conductivity greatly hinder their practical applications. In this work, we demonstrate a novel strategy to prepare monoclinic lithium vanadium phosphate nanoparticles implanted in carbon nanofibers as the cathodes of Li-ion cells with high capacity, flexibility, long cycle stability and significantly improved high-rate performance. The composite nanofibers were obtained by electrospinning using polyacrylonitrile and Li3V2(PO4)3 nanoparticles, followed by annealing and coating with a thin layer of carbon by plasma enhanced chemical vapor deposition. The Li3V2(PO4)3 nanocrystals with the monoclinic phase were uniformly distributed in the composite nanofibers. The electrochemical performances of the as-prepared binder-free fibrous cathodes were characterized by potentiostatic and galvanostatic tests. At the rate of 0.5 C in the range of 3.0-4.3 V, the composite displayed an initial discharge capacity of 128 mA h g-1 (96.2% of the theoretical capacity). A discharge capacity of 120 mA h g-1 was observed even at a high rate of 10 C, and a capacity retention of 98.9% was maintained after 500 cycles at 5 C, indicating excellent high-rate capability and capacity retention. Compared to the control samples without a carbon outer-layer, the composite nanofibers with carbon coating demonstrated much better electrochemical performances. It indicates that the carbon coating can further protect the structural integrity of nanofabric electrodes during the charge/discharge processes without hindering the Li-ion mobility and also can prevent undesired side reactions with an electrolyte, thus greatly improving the rate performance and cyclic stability of the cathode.Lithiated transition metal phosphates with large theoretical capacities have

  3. GDH Integral on the Proton from Asymmetries

    SciTech Connect

    Yelena Prok

    2004-05-01

    Inclusive double spin electron asymmetries have been measured by scattering polarized electrons off the solid polarized {sup 15}NH{sub 3} target in Hall B of Jefferson Lab in 2000-2001. The virtual photon asymmetry A{sub 1} (x), the longitudinal spin structure function, g{sub 1} (x, Q{sup 2}), and the first moment, {Gamma}{sub 1}{sup p}, have been evaluated for a kinematic range of 0.05 {ge} Q{sup 2} {ge} 4.5 GeV{sup 2}. The extracted results complement the existing data in the resonance region, extending it to lower and higher Q{sup 2} regions. The results are important in the study of Q{sup 2} evolution of nucleon structure from the hadronic to partonic degrees of freedom.

  4. Li3V2(PO4)3 encapsulated flexible free-standing nanofabric cathodes for fast charging and long life-cycle lithium-ion batteries.

    PubMed

    Sun, Pingping; Zhao, Xueying; Chen, Renpeng; Chen, Tao; Ma, Lianbo; Fan, Qi; Lu, Hongling; Hu, Yi; Tie, Zuoxiu; Jin, Zhong; Xu, Qingyu; Liu, Jie

    2016-04-14

    Lithiated transition metal phosphates with large theoretical capacities have emerged as promising cathode materials for rechargeable lithium-ion batteries. However, the poor kinetic properties caused by their low intrinsic electronic and ionic conductivity greatly hinder their practical applications. In this work, we demonstrate a novel strategy to prepare monoclinic lithium vanadium phosphate nanoparticles implanted in carbon nanofibers as the cathodes of Li-ion cells with high capacity, flexibility, long cycle stability and significantly improved high-rate performance. The composite nanofibers were obtained by electrospinning using polyacrylonitrile and Li3V2(PO4)3 nanoparticles, followed by annealing and coating with a thin layer of carbon by plasma enhanced chemical vapor deposition. The Li3V2(PO4)3 nanocrystals with the monoclinic phase were uniformly distributed in the composite nanofibers. The electrochemical performances of the as-prepared binder-free fibrous cathodes were characterized by potentiostatic and galvanostatic tests. At the rate of 0.5 C in the range of 3.0-4.3 V, the composite displayed an initial discharge capacity of 128 mA h g(-1) (96.2% of the theoretical capacity). A discharge capacity of 120 mA h g(-1) was observed even at a high rate of 10 C, and a capacity retention of 98.9% was maintained after 500 cycles at 5 C, indicating excellent high-rate capability and capacity retention. Compared to the control samples without a carbon outer-layer, the composite nanofibers with carbon coating demonstrated much better electrochemical performances. It indicates that the carbon coating can further protect the structural integrity of nanofabric electrodes during the charge/discharge processes without hindering the Li-ion mobility and also can prevent undesired side reactions with an electrolyte, thus greatly improving the rate performance and cyclic stability of the cathode. PMID:26990080

  5. Oxygen recoil implant from SiO{sub 2} layers into single-crystalline silicon

    SciTech Connect

    Wang, G.; Chen, Y.; Li, D.; Oak, S.; Srivastav, G.; Banerjee, S.; Tasch, A.; Merrill, P.; Bleiler, R.

    2001-06-01

    It is important to understand the distribution of recoil-implanted atoms and the impact on device performance when ion implantation is performed at a high dose through surface materials into single crystalline silicon. For example, in ultralarge scale integration impurity ions are often implanted through a thin layer of screen oxide and some of the oxygen atoms are inevitably recoil implanted into single-crystalline silicon. Theoretical and experimental studies have been performed to investigate this phenomenon. We have modified the Monte Carlo ion implant simulator, UT-Marlowe (B. Obradovic, G. Wang, Y. Chen, D. Li, C. Snell, and A. F. Tasch, UT-MARLOWE Manual, 1999), which is based on the binary collision approximation, to follow the full cascade and to dynamically modify the stoichiometry of the Si layer as oxygen atoms are knocked into it. CPU reduction techniques are used to relieve the demand on computational power when such a full cascade simulation is involved. Secondary ion mass spectrometry (SIMS) profiles of oxygen have been carefully obtained for high dose As and BF{sub 2} implants at different energies through oxide layers of various thicknesses, and the simulated oxygen profiles are found to agree very well with the SIMS data. {copyright} 2001 American Institute of Physics.

  6. Barriers and facilitators to integrating care: experiences from the English Integrated Care Pilots

    PubMed Central

    Ling, Tom; Brereton, Laura; Conklin, Annalijn; Newbould, Jennifer; Roland, Martin

    2012-01-01

    Background: In 2008, the English Department of Health appointed 16 ‘Integrated Care Pilots’ which used a range of approaches to provide better integrated care. We report qualitative analyses from a three-year multi-method evaluation to identify barriers and facilitators to successful integration of care. Theory and methods: Data were analysed from transcripts of 213 in-depth staff interviews, and from semi-structured questionnaires (the ‘Living Document’) completed by staff in pilot sites at six points over a two-year period. Emerging findings were therefore built from ‘bottom up’ and grounded in the data. However, we were then interested in how these findings compared and contrasted with more generic analyses. Therefore after our analyses were complete we then systematically compared and contrasted the findings with the analysis of barriers and facilitators to quality improvement identified in a systematic review by Kaplan et al. (2010) and the analysis of more micro-level shapers of behaviour found in Normalisation Process Theory (May et al. 2007). Neither of these approaches claims to be full blown theories but both claim to provide mid-range theoretical arguments which may be used to structure existing data and which can be undercut or reinforced by new data. Results and discussion: Many barriers and facilitators to integrating care are those of any large-scale organisational change. These include issues relating to leadership, organisational culture, information technology, physician involvement, and availability of resources. However, activities which appear particularly important for delivering integrated care include personal relationships between leaders in different organisations, the scale of planned activities, governance and finance arrangements, support for staff in new roles, and organisational and staff stability. We illustrate our analyses with a ‘routemap’ which identifies questions that providers may wish to consider when planning

  7. Quantum tunneling splittings from path-integral molecular dynamics.

    PubMed

    Mátyus, Edit; Wales, David J; Althorpe, Stuart C

    2016-03-21

    We illustrate how path-integral molecular dynamics can be used to calculate ground-state tunnelling splittings in molecules or clusters. The method obtains the splittings from ratios of density matrix elements between the degenerate wells connected by the tunnelling. We propose a simple thermodynamic integration scheme for evaluating these elements. Numerical tests on fully dimensional malonaldehyde yield tunnelling splittings in good overall agreement with the results of diffusion Monte Carlo calculations. PMID:27004863

  8. Does integrated governance lead to integrated patient care? Findings from the innovation forum.

    PubMed

    Beech, Roger; Henderson, Catherine; Ashby, Sue; Dickinson, Angela; Sheaff, Rod; Windle, Karen; Wistow, Gerald; Knapp, Martin

    2013-11-01

    Good integration of services that aim to reduce avoidable acute hospital bed use by older people requires frontline staff to be aware of service options and access them in a timely manner. In three localities where closer inter-organisational integration was taking place, this research sought patients' perceptions of the care received across and within organisational boundaries. Between February and July 2008, qualitative methods were used to map the care journeys of 18 patients (six from each site). Patient interviews (46) covered care received before, at the time of and following a health crisis. Additional interviews (66) were undertaken with carers and frontline staff. Grounded theory-based approaches showed examples of well-integrated care against a background of underuse of services for preventing health crises and a reliance on 'traditional' referral patterns and services at the time of a health crisis. There was scope to raise both practitioner and patient awareness of alternative care options and to expand the availability and visibility of care 'closer to home' services such as rapid response teams. Concerns voiced by patients centred on the adequacy of arrangements for organising ongoing care, while family members reported being excluded from discussions about care arrangements and the roles they were expected to play. The coordination of care was also affected by communication difficulties between practitioners (particularly across organisational boundaries) and a lack of compatible technologies to facilitate information sharing. Finally, closer organisational integration seemed to have limited impact on care at the patient/practitioner interface. To improve care experienced by patients, organisational integration needs to be coupled with vertical integration within organisations to ensure that strategic goals influence the actions of frontline staff. As they experience the complete care journey, feedback from patients can play an important role in the

  9. Development of antimicrobial thermoplastic material from archaeal poly-γ-L-glutamate and its nanofabrication.

    PubMed

    Ashiuchi, Makoto; Fukushima, Kenzo; Oya, Haruna; Hiraoki, Toshihumi; Shibatani, Shigeo; Oka, Nogiho; Nishimura, Hirokazu; Hakuba, Hirofumi; Nakamori, Masahiko; Kitagawa, Masaru

    2013-03-13

    Here we describe a stoichiometric ion-complex of archaeal poly-γ-L-glutamate (L-PGA) and hexadecylpyridinium cation (HDP(+)), called PGAIC, which shows remarkable chemical resistance and potential as a novel functional thermoplastic. PGAIC films suppressed the proliferation of prokaryotic (Escherichia coli, Bacillus subtilis, Salmonella typhimurium, and Staphylococcus aureus) and eukaryotic (Saccharomyces cerevisiae) microorganisms. Moreover, its antifungal activity was demonstrated against a prevalent species of Candida (Candida albicans) and a filamentous fungus (Aspergillus niger). The minimal inhibitory concentrations were estimated as 0.25 mg mL(-1), and zones of growth inhibition appeared when PGAIC-coated polyethylene terephthalate (PET) films were placed in culture plates, whereas PET had very little effect on fungal growth. Soluble PGAIC thus shows promises as an antimicrobial and as a coating substrate. We also succeeded in synthesizing an L-PGA-based nanofiber using an ethanol solution of PGAIC. PMID:23388052

  10. National Call for Organizational Change from Sheltered to Integrated Employment

    ERIC Educational Resources Information Center

    Rogan, Patricia; Rinne, Susan

    2011-01-01

    Our purpose in this article is to contend that organizational change from sheltered to integrated employment is not only possible but necessary, and a federal Employment First agenda must be advanced. Findings are reported from interviews with senior managers from 10 organizations that have shifted their service delivery to community employment,…

  11. Nanofabrication de boites quantiques laterales pour l'optimisation de qubits de spin

    NASA Astrophysics Data System (ADS)

    Camirand Lemyre, Julien

    On présente dans ce travail un nouveau type de qubit de spin dont les performances reposent sur les propriétés d'un seul électron dans une double boîte quantique. Le fort moment dipolaire de la double boite combiné à une large variation du champ magnétique entre les deux boîtes permettrait de réaliser des opérations logiques plus rapidement que dans une seule boîte quantique. Pour maximiser les variations du champ magnétique, on utilisera un micro-aimant placé le plus près possible d'une des deux boîtes. À cette fin, une hétérostructure de GaAs/A1GaAs sur laquelle sont déposées des grilles d'aluminium a été utilisée pour former une double boite quantique latérale. L'occupation par un seul électron de la double boîte est confirmée par des mesures de transport électrique à basse température ainsi que par l'observation du blocage de spin. De plus, un procédé d'oxydation des grilles par plasma d'oxygène a été développé. Une étude des propriétés de l'oxyde formé par cette méthode montre qu'il est possible de placer un micro-aimant directement sur la surface de l'hétérostructure sans affecter l'isolation électrique entre les grilles. Cette nouvelle approche permet de produire des champs magnétiques encore plus intenses que dans les expériences antérieures, pour lesquelles le micro-aimant est placé beaucoup plus loin de la surface. L'ensemble du procédé de fabrication, de la photolithographie à l'électrolithographie, a été développé au cours de ce travail dans les salles blanches du département de génie électrique et dans les salles propres du département de physique de l'Université de Sherbrooke. Ce travail est une étape importante dans la réalisation de qubits de spin plus performants dans les boîtes quantiques latérales. Mots-clés: Information quantique, Spin, Rotations ultra-rapides, Boîtes quantiques latérales, Micro-aimants, Oxydation plasma, Nanofabrication.

  12. Integrating order and distance relationships from heterogeneous maps.

    PubMed

    Graves, M

    1993-01-01

    There is no automatic mechanism to integrate information between heterogeneous genome maps. Currently, integration is a difficult, manual process. We have developed a process for knowledge base design, and we use this to integrate order and distance relationships between genetic linkage, radiation hybrid, and physical maps. Until now, the only way to develop a persistent, knowledge-intensive application was to either develop a new knowledge base from scratch or coerce the application to fit an existing knowledge base. This was not from lack of interest by the knowledge base or database community, but merely from a lack of theoretical tools powerful enough to tackle the problem. We import formalisms from knowledge representation, natural language semantics, programming language research, and databases. These form a strong, theoretical foundation for knowledge base design upon which we have implemented the knowledge base design tool called WEAVE. PMID:7584331

  13. KA-SB: from data integration to large scale reasoning

    PubMed Central

    Roldán-García, María del Mar; Navas-Delgado, Ismael; Kerzazi, Amine; Chniber, Othmane; Molina-Castro, Joaquín; Aldana-Montes, José F

    2009-01-01

    Background The analysis of information in the biological domain is usually focused on the analysis of data from single on-line data sources. Unfortunately, studying a biological process requires having access to disperse, heterogeneous, autonomous data sources. In this context, an analysis of the information is not possible without the integration of such data. Methods KA-SB is a querying and analysis system for final users based on combining a data integration solution with a reasoner. Thus, the tool has been created with a process divided into two steps: 1) KOMF, the Khaos Ontology-based Mediator Framework, is used to retrieve information from heterogeneous and distributed databases; 2) the integrated information is crystallized in a (persistent and high performance) reasoner (DBOWL). This information could be further analyzed later (by means of querying and reasoning). Results In this paper we present a novel system that combines the use of a mediation system with the reasoning capabilities of a large scale reasoner to provide a way of finding new knowledge and of analyzing the integrated information from different databases, which is retrieved as a set of ontology instances. This tool uses a graphical query interface to build user queries easily, which shows a graphical representation of the ontology and allows users o build queries by clicking on the ontology concepts. Conclusion These kinds of systems (based on KOMF) will provide users with very large amounts of information (interpreted as ontology instances once retrieved), which cannot be managed using traditional main memory-based reasoners. We propose a process for creating persistent and scalable knowledgebases from sets of OWL instances obtained by integrating heterogeneous data sources with KOMF. This process has been applied to develop a demo tool , which uses the BioPax Level 3 ontology as the integration schema, and integrates UNIPROT, KEGG, CHEBI, BRENDA and SABIORK databases. PMID:19796402

  14. High throughput nanofabrication of silicon nanowire and carbon nanotube tips on AFM probes by stencil-deposited catalysts.

    PubMed

    Engstrom, Daniel S; Savu, Veronica; Zhu, Xueni; Bu, Ian Y Y; Milne, William I; Brugger, Juergen; Boggild, Peter

    2011-04-13

    A new and versatile technique for the wafer scale nanofabrication of silicon nanowire (SiNW) and multiwalled carbon nanotube (MWNT) tips on atomic force microscope (AFM) probes is presented. Catalyst material for the SiNW and MWNT growth was deposited on prefabricated AFM probes using aligned wafer scale nanostencil lithography. Individual vertical SiNWs were grown epitaxially by a catalytic vapor-liquid-solid (VLS) process and MWNTs were grown by a plasma-enhanced chemical vapor (PECVD) process on the AFM probes. The AFM probes were tested for imaging micrometers-deep trenches, where they demonstrated a significantly better performance than commercial high aspect ratio tips. Our method demonstrates a reliable and cost-efficient route toward wafer scale manufacturing of SiNW and MWNT AFM probes. PMID:21446752

  15. A wafer-scale backplane-assisted resonating nanoantenna array SERS device created by tunable thermal dewetting nanofabrication

    NASA Astrophysics Data System (ADS)

    Chang, Te-Wei; Ranjan Gartia, Manas; Seo, Sujin; Hsiao, Austin; Logan Liu, Gang

    2014-04-01

    A tunable lithography-less nanofabrication process using a metal thin-film thermal dewetting technique has been developed to fabricate wafer-scale and uniform plasmonic substrates at low cost for optimal performance in surface enhanced Raman scattering (SERS) applications. The relationship between the tunable parameters of this process and the corresponding optical and plasmonic characteristic is investigated both experimentally and theoretically to understand the deterministic design of an optimal SERS device with a three-dimensional plasmonic nanoantenna structure. The enhancement of SERS using various nanoplasmonic particle sizes, structure lengths, lateral hot spot spacings and resonating effects are examined and demonstrated. We achieve a uniform optimal enhancement factor of 1.38 × 108 on a 4 in wafer-scale SERS substrate with a backplane-assisted resonating nanoantenna array design. Sensitive environmental nitrate sensing, vitamin detection and oligonucleotide identification are demonstrated on the high-performance SERS device.

  16. Micro/nanofabrication of poly({sub L}-lactic acid) using focused ion beam direct etching

    SciTech Connect

    Oyama, Tomoko Gowa; Nagasawa, Naotsugu; Taguchi, Mitsumasa; Hinata, Toru; Washio, Masakazu; Oshima, Akihiro; Tagawa, Seiichi

    2013-10-14

    Micro/nanofabrication of biocompatible and biodegradable poly({sub L}-lactic acid) (PLLA) using focused Ga ion beam direct etching was evaluated for future bio-device applications. The fabrication performance was determined with different ion fluences and fluxes (beam currents), and it was found that the etching speed and fabrication accuracy were affected by irradiation-induced heat. Focused ion beam (FIB)-irradiated surfaces were analyzed using micro-area X-ray photoelectron spectroscopy. Owing to reactions such as the physical sputtering of atoms and radiation-induced decomposition, PLLA was gradually carbonized with increasing C=C bonds. Controlled micro/nanostructures of PLLA were fabricated with C=C bond-rich surfaces expected to have good cell attachment properties.

  17. Integrated information theory: from consciousness to its physical substrate.

    PubMed

    Tononi, Giulio; Boly, Melanie; Massimini, Marcello; Koch, Christof

    2016-07-01

    In this Opinion article, we discuss how integrated information theory accounts for several aspects of the relationship between consciousness and the brain. Integrated information theory starts from the essential properties of phenomenal experience, from which it derives the requirements for the physical substrate of consciousness. It argues that the physical substrate of consciousness must be a maximum of intrinsic cause-effect power and provides a means to determine, in principle, the quality and quantity of experience. The theory leads to some counterintuitive predictions and can be used to develop new tools for assessing consciousness in non-communicative patients. PMID:27225071

  18. From Classical Nonlinear Integrable Systems to Quantum Shortcuts to Adiabaticity

    NASA Astrophysics Data System (ADS)

    Okuyama, Manaka; Takahashi, Kazutaka

    2016-08-01

    Using shortcuts to adiabaticity, we solve the time-dependent Schrödinger equation that is reduced to a classical nonlinear integrable equation. For a given time-dependent Hamiltonian, the counterdiabatic term is introduced to prevent nonadiabatic transitions. Using the fact that the equation for the dynamical invariant is equivalent to the Lax equation in nonlinear integrable systems, we obtain the counterdiabatic term exactly. The counterdiabatic term is available when the corresponding Lax pair exists and the solvable systems are classified in a unified and systematic way. Multisoliton potentials obtained from the Korteweg-de Vries equation and isotropic X Y spin chains from the Toda equations are studied in detail.

  19. The benefits of integrated chiller retrofits: Excerpts from case studies

    SciTech Connect

    Gartland, L.; Sartor, D.

    1998-07-01

    An integrated chiller retrofit is an effective way to turn the CFC phaseout into an opportunity for energy efficiency and money savings. The 1996 moratorium on CFC production means many chillers will soon have to be replaced or converted to use alternative refrigerants. Integrating building load reductions and system improvements with chiller replacements and/or conversions can solve building comfort and maintenance problem, increase energy efficiency, save money on utility bills, increase a building's asset value, and produce a more financially attractive project. The poll $ense program at Lawrence Berkeley National laboratory has been gathering integrated chiller retrofit case studies from its regional workshops. This paper presents some of the best examples of different aspects of integrated retrofits. Example projects include: (1) a chiller conversion, (2) a chiller replacement, (3) an effective cooling system renovation, (4) a model building load reduction scheme, (5) an illustration of integrated chiller retrofit economics, (6) a chiller sizing cautionary tale, and (7) an environmentally friendly and cost-effective retrofit. These projects enumerate retrofit measures to consider, and show how much more effective it is to widen your focus from the chiller alone to the entire building when facing the CFC phaseout.

  20. When Can Information from Ordinal Scale Variables Be Integrated?

    ERIC Educational Resources Information Center

    Kemp, Simon; Grace, Randolph C.

    2010-01-01

    Many theoretical constructs of interest to psychologists are multidimensional and derive from the integration of several input variables. We show that input variables that are measured on ordinal scales cannot be combined to produce a stable weakly ordered output variable that allows trading off the input variables. Instead a partial order is…

  1. Method and system of integrating information from multiple sources

    DOEpatents

    Alford, Francine A.; Brinkerhoff, David L.

    2006-08-15

    A system and method of integrating information from multiple sources in a document centric application system. A plurality of application systems are connected through an object request broker to a central repository. The information may then be posted on a webpage. An example of an implementation of the method and system is an online procurement system.

  2. Learning SQL Programming with Interactive Tools: From Integration to Personalization

    ERIC Educational Resources Information Center

    Brusilovsky, Pete; Sosnovsky, Sergey; Yudelson, Michael V.; Lee, Danielle H.; Zadorozhny, Vladimir; Zhou, Xin

    2010-01-01

    Rich, interactive eLearning tools receive a lot of attention nowadays from both practitioners and researchers. However, broader dissemination of these tools is hindered by the technical difficulties of their integration into existing platforms. This article explores the technical and conceptual problems of using several interactive educational…

  3. Integrative Medicine Selects Best Practice from Public Health and Biomedicine

    PubMed Central

    Ryan, Terence J

    2013-01-01

    The meaning of terms Integrated and Integrative are described variously by an amalgam of latest scientific advances with ancient healing systems, of complementary medicine and biomedicine, and sexually transmitted infections and HIV/AIDS. It means seamless good quality care between hospital and primary care. They provoke approval mostly from patients and disapproval mostly from advocates of science and evidence-based medicine. The Institute of Applied Dermatology in Kasaragod, Kerala, India has championed a mix of Biomedicine, Yoga and herbals from Ayurvedic medicine, partly based on publications from the Department of Dermatology of the University of Oxford. In Oxford dermatology, acceptance of value of integrative medicine (IM) is demonstrated, especially in wound healing and the skin's blood supply. This has long featured in the university's research program. A variety of approaches to the practice of medicine are illustrated with reference to Osler, Garrod, and Doll. IM is believed to underlie contemporarily best practice. Particular emphasis is given to the control of heat, pain, redness, and swelling, all manifestations of inflammation, and the importance of emotion as a stimulus or inhibitor carried by neural pathways. These may explain some unbelievable Asian practices and one of the many roles of Yoga. The concept of Integrative is expanded to include care of the earth and nutrition, the hazards of climate change, Gardens for Health, do (k) no (w) harm as a key to good practice. PMID:23716803

  4. Serotyping of Salmonella Isolates from Broiler Vertical Integrations in Colombia

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study analyzed 106 Salmonella isolates from different points in broiler vertical integrations of two important poultry areas of Colombia. It was possible to identify the presence of Salmonella in five categories: breeder farm (17.9%), hatchery (6.6 %), broiler farm (38.7 %), processing plant (9...

  5. Integrative change model in psychotherapy: Perspectives from Indian thought

    PubMed Central

    Manickam, L. S. S

    2013-01-01

    Different psychotherapeutic approaches claim positive changes in patients as a result of therapy. Explanations related to the change process led to different change models. Some of the change models are experimentally oriented whereas some are theoretical. Apart from the core models of behavioral, psychodynamic, humanistic, cognitive and spiritually oriented models there are specific models, within psychotherapy that explains the change process. Integrative theory of a person as depicted in Indian thought provides a common ground for the integration of various therapies. Integrative model of change based on Indian thought, with specific reference to psychological concepts in Upanishads, Ayurveda, Bhagavad Gita and Yoga are presented. Appropriate psychological tools may be developed in order to help the clinicians to choose the techniques that match the problem and the origin of the dimension. Explorations have to be conducted to develop more techniques that are culturally appropriate and clinically useful. Research has to be initiated to validate the identified concepts. PMID:23858275

  6. Defining nephrotic syndrome from an integrative genomics perspective.

    PubMed

    Sampson, Matthew G; Hodgin, Jeffrey B; Kretzler, Matthias

    2015-01-01

    Nephrotic syndrome (NS) is a clinical condition with a high degree of morbidity and mortality, caused by failure of the glomerular filtration barrier, resulting in massive proteinuria. Our current diagnostic, prognostic and therapeutic decisions in NS are largely based upon clinical or histological patterns such as "focal segmental glomerulosclerosis" or "steroid sensitive". Yet these descriptive classifications lack the precision to explain the physiologic origins and clinical heterogeneity observed in this syndrome. A more precise definition of NS is required to identify mechanisms of disease and capture various clinical trajectories. An integrative genomics approach to NS applies bioinformatics and computational methods to comprehensive experimental, molecular and clinical data for holistic disease definition. A unique aspect is analysis of data together to discover NS-associated molecules, pathways, and networks. Integrating multidimensional datasets from the outset highlights how molecular lesions impact the entire individual. Data sets integrated range from genetic variation to gene expression, to histologic changes, to progression of chronic kidney disease (CKD). This review will introduce the tenets of integrative genomics and suggest how it can increase our understanding of NS from molecular and pathophysiological perspectives. A diverse group of genome-scale experiments are presented that have sought to define molecular signatures of NS. Finally, the Nephrotic Syndrome Study Network (NEPTUNE) will be introduced as an international, prospective cohort study of patients with NS that utilizes an integrated systems genomics approach from the outset. A major NEPTUNE goal is to achieve comprehensive disease definition from a genomics perspective and identify shared molecular drivers of disease. PMID:24890338

  7. Nanofabrication for On-Chip Optical Levitation, Atom-Trapping, and Superconducting Quantum Circuits

    NASA Astrophysics Data System (ADS)

    Norte, Richard Alexander

    Researchers have spent decades refining and improving their methods for fabricating smaller, finer-tuned, higher-quality nanoscale optical elements with the goal of making more sensitive and accurate measurements of the world around them using optics. Quantum optics has been a well-established tool of choice in making these increasingly sensitive measurements which have repeatedly pushed the limits on the accuracy of measurement set forth by quantum mechanics. A recent development in quantum optics has been a creative integration of robust, high-quality, and well-established macroscopic experimental systems with highly-engineerable on-chip nanoscale oscillators fabricated in cleanrooms. However, merging large systems with nanoscale oscillators often require them to have extremely high aspect-ratios, which make them extremely delicate and difficult to fabricate with an experimentally reasonable repeatability, yield and high quality. In this work we give an overview of our research, which focused on microscopic oscillators which are coupled with macroscopic optical cavities towards the goal of cooling them to their motional ground state in room temperature environments. The quality factor of a mechanical resonator is an important figure of merit for various sensing applications and observing quantum behavior. We demonstrated a technique for pushing the quality factor of a micromechanical resonator beyond conventional material and fabrication limits by using an optical field to stiffen and trap a particular motional mode of a nanoscale oscillator. Optical forces increase the oscillation frequency by storing most of the mechanical energy in a nearly loss-less optical potential, thereby strongly diluting the effects of material dissipation. By placing a 130 nm thick SiO2 pendulum in an optical standing wave, we achieve an increase in the pendulum center-of-mass frequency from 6.2 to 145 kHz. The corresponding quality factor increases 50-fold from its intrinsic value to

  8. Wind Integration Datasets from the National Renewable Energy Laboratory (NREL)

    DOE Data Explorer

    The Wind Integration Datasets provide time-series wind data for 2004, 2005, and 2006. They are intended to be used by energy professionals such as transmission planners, utility planners, project developers, and university researchers, helping them to perform comparisons of sites and estimate power production from hypothetical wind plants. NREL cautions that the information from modeled data may not match wind resource information shown on NREL;s state wind maps as they were created for different purposes and using different methodologies.

  9. Integrated process for preparing a carboxylic acid from an alkane

    DOEpatents

    Benderly, Abraham; Chadda, Nitin; Sevon, Douglass

    2011-12-20

    The present invention relates to an integrated process for producing unsaturated carboxylic acids from the corresponding C.sub.2-C.sub.4 alkane. The process begins with performance of thermally integrated dehydrogenation reactions which convert a C.sub.2-C.sub.4 alkane to its corresponding C.sub.2-C.sub.4 alkene, and which involve exothermically converting a portion of an alkane to its corresponding alkene by oxidative dehydrogenation in an exothermic reaction zone, in the presence of oxygen and a suitable catalyst, and then feeding the products of the exothermic reaction zone to an endothermic reaction zone wherein at least a portion of the remaining unconverted alkane is endothermically dehydrogenated to form an additional quantity of the same corresponding alkene, in the presence of carbon dioxide and an other suitable catalyst. The alkene products of the thermally integrated dehydrogenation reactions are then provided to a catalytic vapor phase partial oxidation process for conversion of the alkene to the corresponding unsaturated carboxylic acid or nitrile. Unreacted alkene and carbon dioxide are recovered from the oxidation product stream and recycled back to the thermally integrated dehydrogenation reactions.

  10. Assessing the environmental sustainability of ethanol from integrated biorefineries.

    PubMed

    Falano, Temitope; Jeswani, Harish K; Azapagic, Adisa

    2014-06-01

    This paper considers the life cycle environmental sustainability of ethanol produced in integrated biorefineries together with chemicals and energy. Four types of second-generation feedstocks are considered: wheat straw, forest residue, poplar, and miscanthus. Seven out of 11 environmental impacts from ethanol are negative, including greenhouse gas (GHG) emissions, when the system is credited for the co-products, indicating environmental savings. Ethanol from poplar is the best and straw the worst option for most impacts. Land use change from forest to miscanthus increases the GHG emissions several-fold. For poplar, the effect is opposite: converting grassland to forest reduces the emissions by three-fold. Compared to fossil and first-generation ethanol, ethanol from integrated biorefineries is more sustainable for most impacts, with the exception of wheat straw. Pure ethanol saves up to 87% of GHG emissions compared to petrol per MJ of fuel. However, for the current 5% ethanol-petrol blends, the savings are much smaller (<3%). Therefore, unless much higher blends become widespread, the contribution of ethanol from integrated biorefineries to the reduction of GHG emissions will be insignificant. Yet, higher ethanol blends would lead to an increase in some impacts, notably terrestrial and freshwater toxicity as well as eutrophication for some feedstocks. PMID:24478110

  11. Assessing the environmental sustainability of ethanol from integrated biorefineries

    PubMed Central

    Falano, Temitope; Jeswani, Harish K; Azapagic, Adisa

    2014-01-01

    This paper considers the life cycle environmental sustainability of ethanol produced in integrated biorefineries together with chemicals and energy. Four types of second-generation feedstocks are considered: wheat straw, forest residue, poplar, and miscanthus. Seven out of 11 environmental impacts from ethanol are negative, including greenhouse gas (GHG) emissions, when the system is credited for the co-products, indicating environmental savings. Ethanol from poplar is the best and straw the worst option for most impacts. Land use change from forest to miscanthus increases the GHG emissions several-fold. For poplar, the effect is opposite: converting grassland to forest reduces the emissions by three-fold. Compared to fossil and first-generation ethanol, ethanol from integrated biorefineries is more sustainable for most impacts, with the exception of wheat straw. Pure ethanol saves up to 87% of GHG emissions compared to petrol per MJ of fuel. However, for the current 5% ethanol–petrol blends, the savings are much smaller (<3%). Therefore, unless much higher blends become widespread, the contribution of ethanol from integrated biorefineries to the reduction of GHG emissions will be insignificant. Yet, higher ethanol blends would lead to an increase in some impacts, notably terrestrial and freshwater toxicity as well as eutrophication for some feedstocks. PMID:24478110

  12. Spin foam models for quantum gravity from lattice path integrals

    SciTech Connect

    Bonzom, Valentin

    2009-09-15

    Spin foam models for quantum gravity are derived from lattice path integrals. The setting involves variables from both lattice BF theory and Regge calculus. The action consists in a Regge action, which depends on areas, dihedral angles and includes the Immirzi parameter. In addition, a measure is inserted to ensure a consistent gluing of simplices, so that the amplitude is dominated by configurations that satisfy the parallel transport relations. We explicitly compute the path integral as a sum over spin foams for a generic measure. The Freidel-Krasnov and Engle-Pereira-Rovelli models correspond to a special choice of gluing. In this case, the equations of motion describe genuine geometries, where the constraints of area-angle Regge calculus are satisfied. Furthermore, the Immirzi parameter drops out of the on-shell action, and stationarity with respect to area variations requires spacetime geometry to be flat.

  13. Nanophotonic integrated circuits from nanoresonators grown on silicon

    NASA Astrophysics Data System (ADS)

    Chen, Roger; Ng, Kar Wei; Ko, Wai Son; Parekh, Devang; Lu, Fanglu; Tran, Thai-Truong D.; Li, Kun; Chang-Hasnain, Connie

    2014-07-01

    Harnessing light with photonic circuits promises to catalyse powerful new technologies much like electronic circuits have in the past. Analogous to Moore’s law, complexity and functionality of photonic integrated circuits depend on device size and performance scale. Semiconductor nanostructures offer an attractive approach to miniaturize photonics. However, shrinking photonics has come at great cost to performance, and assembling such devices into functional photonic circuits has remained an unfulfilled feat. Here we demonstrate an on-chip optical link constructed from InGaAs nanoresonators grown directly on a silicon substrate. Using nanoresonators, we show a complete toolkit of circuit elements including light emitters, photodetectors and a photovoltaic power supply. Devices operate with gigahertz bandwidths while consuming subpicojoule energy per bit, vastly eclipsing performance of prior nanostructure-based optoelectronics. Additionally, electrically driven stimulated emission from an as-grown nanostructure is presented for the first time. These results reveal a roadmap towards future ultradense nanophotonic integrated circuits.

  14. Soap from Nutmeg: An Integrated Introductory Organic Chemistry Laboratory Experiment

    NASA Astrophysics Data System (ADS)

    de Mattos, Marcio C. S.; Nicodem, David E.

    2002-01-01

    The extraction of trimyristin from nutmeg, its purification, and its conversion to a soap (sodium myristate) are described. Concepts such as the isolation of a natural product, recrystallization, identification of a solid, solubility, acidity and basicity, and organic reaction can be presented to students using integrated experiments in an introductory experimental chemistry laboratory. These experiments can easily be done in three class periods of four hours.

    See Letter re: this article.

  15. Integration of plastids with their hosts: Lessons learned from dinoflagellates

    PubMed Central

    Dorrell, Richard G.; Howe, Christopher J.

    2015-01-01

    After their endosymbiotic acquisition, plastids become intimately connected with the biology of their host. For example, genes essential for plastid function may be relocated from the genomes of plastids to the host nucleus, and pathways may evolve within the host to support the plastid. In this review, we consider the different degrees of integration observed in dinoflagellates and their associated plastids, which have been acquired through multiple different endosymbiotic events. Most dinoflagellate species possess plastids that contain the pigment peridinin and show extreme reduction and integration with the host biology. In some species, these plastids have been replaced through serial endosymbiosis with plastids derived from a different phylogenetic derivation, of which some have become intimately connected with the biology of the host whereas others have not. We discuss in particular the evolution of the fucoxanthin-containing dinoflagellates, which have adapted pathways retained from the ancestral peridinin plastid symbiosis for transcript processing in their current, serially acquired plastids. Finally, we consider why such a diversity of different degrees of integration between host and plastid is observed in different dinoflagellates and how dinoflagellates may thus inform our broader understanding of plastid evolution and function. PMID:25995366

  16. Integration of plastids with their hosts: Lessons learned from dinoflagellates.

    PubMed

    Dorrell, Richard G; Howe, Christopher J

    2015-08-18

    After their endosymbiotic acquisition, plastids become intimately connected with the biology of their host. For example, genes essential for plastid function may be relocated from the genomes of plastids to the host nucleus, and pathways may evolve within the host to support the plastid. In this review, we consider the different degrees of integration observed in dinoflagellates and their associated plastids, which have been acquired through multiple different endosymbiotic events. Most dinoflagellate species possess plastids that contain the pigment peridinin and show extreme reduction and integration with the host biology. In some species, these plastids have been replaced through serial endosymbiosis with plastids derived from a different phylogenetic derivation, of which some have become intimately connected with the biology of the host whereas others have not. We discuss in particular the evolution of the fucoxanthin-containing dinoflagellates, which have adapted pathways retained from the ancestral peridinin plastid symbiosis for transcript processing in their current, serially acquired plastids. Finally, we consider why such a diversity of different degrees of integration between host and plastid is observed in different dinoflagellates and how dinoflagellates may thus inform our broader understanding of plastid evolution and function. PMID:25995366

  17. Ensemble-type numerical uncertainty information from single model integrations

    SciTech Connect

    Rauser, Florian Marotzke, Jochem; Korn, Peter

    2015-07-01

    We suggest an algorithm that quantifies the discretization error of time-dependent physical quantities of interest (goals) for numerical models of geophysical fluid dynamics. The goal discretization error is estimated using a sum of weighted local discretization errors. The key feature of our algorithm is that these local discretization errors are interpreted as realizations of a random process. The random process is determined by the model and the flow state. From a class of local error random processes we select a suitable specific random process by integrating the model over a short time interval at different resolutions. The weights of the influences of the local discretization errors on the goal are modeled as goal sensitivities, which are calculated via automatic differentiation. The integration of the weighted realizations of local error random processes yields a posterior ensemble of goal approximations from a single run of the numerical model. From the posterior ensemble we derive the uncertainty information of the goal discretization error. This algorithm bypasses the requirement of detailed knowledge about the models discretization to generate numerical error estimates. The algorithm is evaluated for the spherical shallow-water equations. For two standard test cases we successfully estimate the error of regional potential energy, track its evolution, and compare it to standard ensemble techniques. The posterior ensemble shares linear-error-growth properties with ensembles of multiple model integrations when comparably perturbed. The posterior ensemble numerical error estimates are of comparable size as those of a stochastic physics ensemble.

  18. The conquest of middle-earth: combining top-down and bottom-up nanofabrication for constructing nanoparticle based devices

    NASA Astrophysics Data System (ADS)

    Diaz Fernandez, Yuri A.; Gschneidtner, Tina A.; Wadell, Carl; Fornander, Louise H.; Lara Avila, Samuel; Langhammer, Christoph; Westerlund, Fredrik; Moth-Poulsen, Kasper

    2014-11-01

    The development of top-down nanofabrication techniques has opened many possibilities for the design and realization of complex devices based on single molecule phenomena such as e.g. single molecule electronic devices. These impressive achievements have been complemented by the fundamental understanding of self-assembly phenomena, leading to bottom-up strategies to obtain hybrid nanomaterials that can be used as building blocks for more complex structures. In this feature article we highlight some relevant published work as well as present new experimental results, illustrating the versatility of self-assembly methods combined with top-down fabrication techniques for solving relevant challenges in modern nanotechnology. We present recent developments on the use of hierarchical self-assembly methods to bridge the gap between sub-nanometer and micrometer length scales. By the use of non-covalent self-assembly methods, we show that we are able to control the positioning of nanoparticles on surfaces, and to address the deterministic assembly of nano-devices with potential applications in plasmonic sensing and single-molecule electronics experiments.The development of top-down nanofabrication techniques has opened many possibilities for the design and realization of complex devices based on single molecule phenomena such as e.g. single molecule electronic devices. These impressive achievements have been complemented by the fundamental understanding of self-assembly phenomena, leading to bottom-up strategies to obtain hybrid nanomaterials that can be used as building blocks for more complex structures. In this feature article we highlight some relevant published work as well as present new experimental results, illustrating the versatility of self-assembly methods combined with top-down fabrication techniques for solving relevant challenges in modern nanotechnology. We present recent developments on the use of hierarchical self-assembly methods to bridge the gap between

  19. Integrative Analysis of Metabolic Models – from Structure to Dynamics

    PubMed Central

    Hartmann, Anja; Schreiber, Falk

    2015-01-01

    The characterization of biological systems with respect to their behavior and functionality based on versatile biochemical interactions is a major challenge. To understand these complex mechanisms at systems level modeling approaches are investigated. Different modeling formalisms allow metabolic models to be analyzed depending on the question to be solved, the biochemical knowledge and the availability of experimental data. Here, we describe a method for an integrative analysis of the structure and dynamics represented by qualitative and quantitative metabolic models. Using various formalisms, the metabolic model is analyzed from different perspectives. Determined structural and dynamic properties are visualized in the context of the metabolic model. Interaction techniques allow the exploration and visual analysis thereby leading to a broader understanding of the behavior and functionality of the underlying biological system. The System Biology Metabolic Model Framework (SBM2 – Framework) implements the developed method and, as an example, is applied for the integrative analysis of the crop plant potato. PMID:25674560

  20. ESA's Integral satellite ready for lift-off from Baikonur

    NASA Astrophysics Data System (ADS)

    2002-10-01

    ESA's INTEGRAL (International Gamma Ray Astrophysics Laboratory) satellite, will be launched by a Proton launcher from Baikonur, Kazakhstan on 17 October at 06:41 CEST (Central European Summer Time). The most sensitive gamma-ray observatory ever launched, INTEGRAL is a truly international mission involving all ESA member states plus the USA and Russia. It carries four instruments from teams led by scientists in Italy, France, Germany, Denmark and Spain to gather and analyse gamma-rays, X-rays and visible light from celestial objects. INTEGRAL will give astronomers across the world their clearest views yet of the most extreme environments in the Universe. It will detect radiation from the most violent events far away and from processes that made the Universe inhabitable. Media representatives in Europe can follow the videotransmission of the launch at ESA/Darmstadt (ESOC) in Germany, which will be acting as the main European press centre, ESA/Noordwijk (ESTEC) in the Netherlands, ESA/Frascati (ESRIN) in Italy or ESA/Villafranca (VILSPA) in Spain. At each site ESA specialists will be available for interviews. Media representatives wishing to attend are requested to complete the attached reply form and fax it to the Communication Office at the establishment of their choice. The ESA TV Service will provide video news releases and live coverage of the launch between 06:15-07:00 and 08:00-08:30 CEST. Details of the transmission schedule for the various Video News Releases can be found on http://television.esa.int The launch can also be followed live on the internet at www.esa.int/integrallaunch starting at 06:15 hrs.

  1. Wearable smart systems: from technologies to integrated systems.

    PubMed

    Lymberis, A

    2011-01-01

    Wearable technology and integrated systems, so called Smart Wearable Systems (SWS) have demonstrated during the last 10-15 years significant advances in terms of, miniaturisation, seamless integration, data processing & communication, functionalisation and comfort. This is mainly due to the huge progress in sciences and technologies e.g. biomedical and micro & nano technologies, but also to a strong demand for new applications such as continuous personal health monitoring, healthy lifestyle support, human performance monitoring and support of professionals at risk. Development of wearable systems based of smart textile have, in addition, benefited from the eagerness of textile industry to develop new value-added apparel products like functionalized garments and smart clothing. Research and development in these areas has been strongly promoted worldwide. In Europe the major R&D activities were supported through the Information & Communication Technologies (ICT) priority of the R&D EU programs. The paper presents and discusses the main achievements towards integrated systems as well as future challenges to be met in order to reach a market with reliable and high value-added products. PMID:22255095

  2. Size-controlled conformal nanofabrication of biotemplated three-dimensional TiO2 and ZnO nanonetworks

    PubMed Central

    Ceylan, Hakan; Ozgit-Akgun, Cagla; Erkal, Turan S.; Donmez, Inci; Garifullin, Ruslan; Tekinay, Ayse B.; Usta, Hakan; Biyikli, Necmi; Guler, Mustafa O.

    2013-01-01

    A solvent-free fabrication of TiO2 and ZnO nanonetworks is demonstrated by using supramolecular nanotemplates with high coating conformity, uniformity, and atomic scale size control. Deposition of TiO2 and ZnO on three-dimensional nanofibrous network template is accomplished. Ultrafine control over nanotube diameter allows robust and systematic evaluation of the electrochemical properties of TiO2 and ZnO nanonetworks in terms of size-function relationship. We observe hypsochromic shift in UV absorbance maxima correlated with decrease in wall thickness of the nanotubes. Photocatalytic activities of anatase TiO2 and hexagonal wurtzite ZnO nanonetworks are found to be dependent on both the wall thickness and total surface area per unit of mass. Wall thickness has effect on photoexcitation properties of both TiO2 and ZnO due to band gap energies and total surface area per unit of mass. The present work is a successful example that concentrates on nanofabrication of intact three-dimensional semiconductor nanonetworks with controlled band gap energies. PMID:23892593

  3. Drug discovery from plant sources: An integrated approach

    PubMed Central

    Katiyar, Chandrakant; Gupta, Arun; Kanjilal, Satyajyoti; Katiyar, Shefali

    2012-01-01

    New drug discovery is facing serious challenges due to reduction in number of new drug approvals coupled with exorbitant rising cost. Advent of combinatorial chemistry provided new hope of higher success rates of new chemical entities (NCEs); however, even this scientific development has failed to improve the success rate in new drug discovery. This scenario has prompted us to come out with a novel approach of integrated drug discovery, where Ayurvedic wisdom can synergize with drug discovery from plant sources. Initial steps in new drug discovery involve identification of NCEs, which can be either sourced through chemical synthesis or can be isolated from natural products through biological activity guided fractionation. The sources of many of the new drugs and active ingredients of medicines are derived from natural products. The starting point for plant-based new drug discovery should be identification of the right candidate plants by applying Ayurvedic wisdom, traditional documented use, tribal non-documented use, and exhaustive literature search. Frequency analysis of the ingredients of the ancient documented formulations and analysis of their Ayurvedic attributes may provide an in-depth idea of the predominance of particular Ayurvedic characteristics based on which appropriate candidate plants may be selected for bioactivity-based fractionation. The integration of Ayurvedic wisdom with drug discovery also brings the need for a paradigm shift in the extraction process from sequential to parallel extraction. Bioassay-guided fractionation of the identified plant may lead to standardized extract or isolated bioactive druggable compound as the new drug. This integrated approach would lead to saving of cost and time, coupled with enhanced success rate in drug discovery. PMID:23049178

  4. Insights and Challenges to Integrating Data from Diverse Ecological Networks

    NASA Astrophysics Data System (ADS)

    Peters, D. P. C.

    2014-12-01

    Many of the most dramatic and surprising effects of global change occur across large spatial extents, from regions to continents, that impact multiple ecosystem types across a range of interacting spatial and temporal scales. The ability of ecologists and inter-disciplinary scientists to understand and predict these dynamics depend, in large part, on existing site-based research infrastructures that developed in response to historic events. Integrating these diverse sources of data is critical to addressing these broad-scale questions. A conceptual approach is presented to synthesize and integrate diverse sources and types of data from different networks of research sites. This approach focuses on developing derived data products through spatial and temporal aggregation that allow datasets collected with different methods to be compared. The approach is illustrated through the integration, analysis, and comparison of hundreds of long-term datasets from 50 ecological sites in the US that represent ecosystem types commonly found globally. New insights were found by comparing multiple sites using common derived data. In addition to "bringing to light" many dark data in a standardized, open access, easy-to-use format, a suite of lessons were learned that can be applied to up and coming research networks in the US and internationally. These lessons will be described along with the challenges, including cyber-infrastructure, cultural, and behavioral constraints associated with the use of big and little data, that may keep ecologists and inter-disciplinary scientists from taking full advantage of the vast amounts of existing and yet-to-be exposed data.

  5. Cockpit integration from a pilot's point of view

    NASA Technical Reports Server (NTRS)

    Green, D. L.

    1982-01-01

    Extensive experience in both operational and engineering test flight was used to suggest straightforward changes to helicopter cockpit and control system design that would improve pilot performance in marginal and instrument flight conditions. Needed control system improvements considered include: (1) separation of yaw from cyclic force trim; (2) pedal force proportional to displacement rate; and (3) integration of engine controls in collective stick. Display improvements needed include: (1) natural cuing of yaw rate in attitude indicator; (2) collective position indication and radar altimeter placed within primary scan; and (3) omnidirectional display of full range airspeed data.

  6. Information Integration from Semantically Heterogeneous Biological Data Sources.

    PubMed

    Caragea, Doina; Bao, Jie; Pathak, Jyotishman; Silvescu, Adrian; Andorf, Carson; Dobbs, Drena; Honavar, Vasant

    2005-08-26

    We present the first prototype of INDUS (Intelligent Data Understanding System), a federated, query-centric system for information integration and knowledge acquisition from distributed, semantically heterogeneous data sources that can be viewed (conceptually) as tables. INDUS employs ontologies and inter-ontology mappings, to enable a user to view a collection of such data sources (regardless of location, internal structure and query interfaces) as though they were a collection of tables structured according to an ontology supplied by the user. This allows INDUS to answer user queries against distributed, semantically heterogeneous data sources without the need for a centralized data warehouse or a common global ontology. PMID:20802821

  7. Toward Integration: From Quantitative Biology to Mathbio-Biomath?

    PubMed Central

    de Pillis, Lisette; Findley, Ann; Joplin, Karl; Pelesko, John; Nelson, Karen; Thompson, Katerina; Usher, David; Watkins, Joseph

    2010-01-01

    In response to the call of BIO2010 for integrating quantitative skills into undergraduate biology education, 30 Howard Hughes Medical Institute (HHMI) Program Directors at the 2006 HHMI Program Directors Meeting established a consortium to investigate, implement, develop, and disseminate best practices resulting from the integration of math and biology. With the assistance of an HHMI-funded mini-grant, led by Karl Joplin of East Tennessee State University, and support in institutional HHMI grants at Emory and University of Delaware, these institutions held a series of summer institutes and workshops to document progress toward and address the challenges of implementing a more quantitative approach to undergraduate biology education. This report summarizes the results of the four summer institutes (2007–2010). The group developed four draft white papers, a wiki site, and a listserv. One major outcome of these meetings is this issue of CBE—Life Sciences Education, which resulted from proposals at our 2008 meeting and a January 2009 planning session. Many of the papers in this issue emerged from or were influenced by these meetings. PMID:20810946

  8. An integrated workflow for characterizing intact phosphoproteins from complex mixtures

    PubMed Central

    Wu, Si; Yang, Feng; Zhao, Rui; Tolić, Nikola; Robinson, Errol W.; Camp, David; Smith, Richard D.; Paša-Tolić, Ljiljana

    2014-01-01

    The phosphorylation of any site on a given protein can affect its activity, degradation rate, ability to dock with other proteins or bind divalent cations, and/or its localization. These effects can operate within the same protein; in fact, multisite phosphorylation is a key mechanism for achieving signal integration in cells. Hence, knowing the overall phosphorylation signature of a protein is essential for understanding the "state" of a cell. However, current technologies to monitor the phosphorylation status of proteins are inefficient at determining the relative stoichiometries of phosphorylation at multiple sites. Here we report a new capability for comprehensive liquid chromatography mass spectrometry (LC/MS) analysis of intact phosphoproteins. The technology platform built upon integrated bottom-up and top-down approach that is facilitated by intact protein reversed-phase (RP)LC concurrently coupled with Fourier transform ion cyclotron resonance (FTICR) MS and fraction collection. As the use of conventional RPLC systems for phosphopeptide identification has proven challenging due to the formation of metal ion complexes at various metal surfaces during LC/MS and ESI-MS analysis, we have developed a “metal-free” RPLC-ESI-MS platform for phosphoprotein characterization. This platform demonstrated a significant sensitivity enhancement for phosphorylated casein proteins enriched from a standard protein mixture and revealed the presence of over 20 casein isoforms arising from genetic variants with varying numbers of phosphorylation sites. The integrated workflow was also applied to an enriched yeast phosphoproteome to evaluate the feasibility of this strategy for characterizing complex biological systems, and revealed ~16% of the detected yeast proteins to have multiple phosphorylation isoforms. Intact protein LC/MS platform for characterization of combinatorial posttranslational modifications (PTMs), with special emphasis on multisite phosphorylation, holds

  9. Information Systems Integration and Enterprise Application Integration (EAI) Adoption: A Case from Financial Services

    ERIC Educational Resources Information Center

    Lam, Wing

    2007-01-01

    Increasingly, organizations find that they need to integrate large number of information systems in order to support enterprise-wide business initiatives such as e-business, supply chain management and customer relationship management. To date, organizations have largely tended to address information systems (IS) integration in an ad-hoc manner.…

  10. From Integrative to Game-Based Integrative Peer Response: High Ability versus Low Ability

    ERIC Educational Resources Information Center

    Wang, J. H.; Chen, S. Y.; Chang, B.; Chan, T. W.

    2016-01-01

    Peer response is useful to improve student writing. However, traditional peer response takes a single mode, which has some problems, such as effort for preparation of documents or ambiguous feedback. To address these problems, this study presents two peer response approaches, that is, an integrative approach and a game-based integrative approach.…

  11. Quantifying chaotic dynamics from integrate-and-fire processes

    SciTech Connect

    Pavlov, A. N.; Pavlova, O. N.; Mohammad, Y. K.; Kurths, J.

    2015-01-15

    Characterizing chaotic dynamics from integrate-and-fire (IF) interspike intervals (ISIs) is relatively easy performed at high firing rates. When the firing rate is low, a correct estimation of Lyapunov exponents (LEs) describing dynamical features of complex oscillations reflected in the IF ISI sequences becomes more complicated. In this work we discuss peculiarities and limitations of quantifying chaotic dynamics from IF point processes. We consider main factors leading to underestimated LEs and demonstrate a way of improving numerical determining of LEs from IF ISI sequences. We show that estimations of the two largest LEs can be performed using around 400 mean periods of chaotic oscillations in the regime of phase-coherent chaos. Application to real data is discussed.

  12. Quantifying chaotic dynamics from integrate-and-fire processes

    NASA Astrophysics Data System (ADS)

    Pavlov, A. N.; Pavlova, O. N.; Mohammad, Y. K.; Kurths, J.

    2015-01-01

    Characterizing chaotic dynamics from integrate-and-fire (IF) interspike intervals (ISIs) is relatively easy performed at high firing rates. When the firing rate is low, a correct estimation of Lyapunov exponents (LEs) describing dynamical features of complex oscillations reflected in the IF ISI sequences becomes more complicated. In this work we discuss peculiarities and limitations of quantifying chaotic dynamics from IF point processes. We consider main factors leading to underestimated LEs and demonstrate a way of improving numerical determining of LEs from IF ISI sequences. We show that estimations of the two largest LEs can be performed using around 400 mean periods of chaotic oscillations in the regime of phase-coherent chaos. Application to real data is discussed.

  13. Exploration of the directed self-assembly based nano-fabrication design space using computational simulations

    NASA Astrophysics Data System (ADS)

    Latypov, Azat; Preil, Moshe; Schmid, Gerard; Xu, Ji; Yi, He; Yoshimoto, Kenji; Zou, Yi

    2013-03-01

    Properly designed geometries of directing pre-patterns broaden the set of lattice symmetries and the local arrangements of patterns achievable by directed self-assembly (DSA) of block copolymers (BCP), compared to the ones achievable in un-directed, bulk systems. We present the results of parametric computational simulation studies, concentrating on exploring the chemoepitaxy or graphoepitaxy directing geometries yielding the DSA structures needed for typical integrated circuits, but not achievable in bulk, undirected annealing of BCP. The examples include the parametric studies of chemoepitaxy and graphoepitaxy DSA patterns etch-transferrable, respectively, into isolated lines and contact hole arrays. The results of the DSA defect simulations are also presented and discussed.

  14. [From virtue bioethics to bioethics personalistic: is integration possible?].

    PubMed

    Pastor, Luis Miguel

    2013-01-01

    In this article we analyze how the idea of virtue as an important element of human ethical action is slowly being lost. There are proposals both in ethics and in bioethics to rehabilitate virtue and to consider it as a very important element of human morality. In particular, in the health sector the rehabilitation of virtue, would imply greater focus on the ethical character of professionals and personal improvement rather than on training for the resolution of ethical cases. Such guidance would also improve the health professional-patient relationship with an increase not only in the technical quality but also in human dimension of health sciences. However, this orientation or tendency in bioethics suffers from a deficit in reasoning due to lack of a complete theory of human action that covers the good and also norms. The second part of the article looks at the relation between of virtue and personalistic bioethics. Virtue is considered as an important element of human action and is integrated with the good and norms. After analyzing and distinguishing between what is today considered personalistic bioethics and the contributions of personalism to bioethics, the paper concludes that the integration of virtue in personalistic bioethics is not only possible but desirable to overcome the ethical minimalism that has resulted from modern day principlism driven bioethics. PMID:23745818

  15. The Evolution from Integration to Inclusion: The Hong Kong Tale

    ERIC Educational Resources Information Center

    Poon-McBrayer, Kim Fong

    2014-01-01

    As a worldwide movement, some forms or stages of inclusive education have been experimented and/or mandated in various countries since the mid-1970s. Integration was piloted in Hong Kong in 1997 and remains the official rhetoric and policy. Three developmental phases of inclusive education, namely, integration, integration in transition to…

  16. Bottom-Up Nanofabrication of Supported Noble Metal Alloy Nanoparticle Arrays for Plasmonics.

    PubMed

    Nugroho, Ferry A A; Iandolo, Beniamino; Wagner, Jakob B; Langhammer, Christoph

    2016-02-23

    Mixing different elements at the nanoscale to obtain alloy nanostructures with fine-tuned physical and chemical properties offers appealing opportunities for nanotechnology and nanoscience. However, despite widespread successful application of alloy nanoparticles made by colloidal synthesis in heterogeneous catalysis, nanoalloy systems have been used very rarely in solid-state devices and nanoplasmonics-related applications. One reason is that such applications require integration in arrays on a surface with compelling demands on nanoparticle arrangement, uniformity in surface coverage, and optimization of the surface density. These cannot be fulfilled even using state-of-the-art self-assembly strategies of colloids. As a solution, we present here a generic bottom-up nanolithography-compatible fabrication approach for large-area arrays of alloy nanoparticles on surfaces. To illustrate the concept, we focus on Au-based binary and ternary alloy systems with Ag, Cu, and Pd, due to their high relevance for nanoplasmonics and complete miscibility, and characterize their optical properties. Moreover, as an example for the relevance of the obtained materials for integration in devices, we demonstrate the superior and hysteresis-free plasmonic hydrogen-sensing performance of the AuPd alloy nanoparticle system. PMID:26828308

  17. Integrated superconducting detectors on semiconductors for quantum optics applications

    NASA Astrophysics Data System (ADS)

    Kaniber, M.; Flassig, F.; Reithmaier, G.; Gross, R.; Finley, J. J.

    2016-05-01

    Semiconductor quantum photonic circuits can be used to efficiently generate, manipulate, route and exploit nonclassical states of light for distributed photon-based quantum information technologies. In this article, we review our recent achievements on the growth, nanofabrication and integration of high-quality, superconducting niobium nitride thin films on optically active, semiconducting GaAs substrates and their patterning to realize highly efficient and ultra-fast superconducting detectors on semiconductor nanomaterials containing quantum dots. Our state-of-the-art detectors reach external detection quantum efficiencies up to 20 % for ~4 nm thin films and single-photon timing resolutions <72 ps. We discuss the integration of such detectors into quantum dot-loaded, semiconductor ridge waveguides, resulting in the on-chip, time-resolved detection of quantum dot luminescence. Furthermore, a prototype quantum optical circuit is demonstrated that enabled the on-chip generation of resonance fluorescence from an individual InGaAs quantum dot, with a linewidth <15 μeV displaced by 1 mm from the superconducting detector on the very same semiconductor chip. Thus, all key components required for prototype quantum photonic circuits with sources, optical components and detectors on the same chip are reported.

  18. Lessons learned from CIRFT testing on SNF vibration integrity study

    SciTech Connect

    Wang, Jy-An John; Wang, Hong; Jiang, Hao; Bevard, Bruce Balkcom; Howard, Rob L.; Scaglione, John M.

    2015-01-01

    A cyclic integrated reversible-bending fatigue tester (CIRFT) was developed to support U.S. NRC and DOE Used Fuel Disposition Campaign studies on high burn-up (HBU) spent nuclear fuel (SNF) transportation during normal conditions of transport (NCT). Two devices were developed; the first CIRFT was successfully installed and operated in the ORNL hot-cells in September 2013. Since hot cell testing commenced several HBU SNF samples from both Zr-4 and M5 clads were investigated. The second CIRFT device was developed in February 2014, and has been used to test clad/fuel surrogate rods (stainless steel with alumina pellet inserts). The second CIRFT machine has also been used for sensor development and test sensitivity analyses, as well as loading boundary condition parameter studies. The lessons learned from CIRFT testing will be presented in this paper.

  19. MALDI Tissue Profiling of Integral Membrane Proteins from Ocular Tissues

    PubMed Central

    Thibault, Danielle B.; Gillam, Christopher J.; Grey, Angus C.; Han, Jun; Schey, Kevin L.

    2008-01-01

    MALDI tissue profiling and imaging have become valuable tools for rapid, direct analysis of tissues to investigate spatial distributions of proteins, potentially leading to an enhanced understanding of the molecular basis of disease. Sample preparation methods developed to date for these techniques produce protein expression profiles from predominantly hydrophilic, soluble proteins. The ability to obtain information about the spatial distribution of integral membrane proteins is critical to more fully understand their role in physiological processes, including transport, adhesion, and signaling. In this communication, a sample preparation method for direct tissue profiling of integral membrane proteins is presented. Spatially resolved profiles for the abundant lens membrane proteins aquaporin 0 (AQP0) and MP20, and the retinal membrane protein opsin, were obtained using this method. MALDI tissue profiling results were validated by analysis of dissected tissue prepared by traditional membrane protein processing methods. Furthermore, direct tissue profiling of lens membrane proteins revealed aged related post-translational modifications, as well as a novel modification that had not been detected using conventional tissue homogenization methods. PMID:18396059

  20. Initial states in integrable quantum field theory quenches from an integral equation hierarchy

    NASA Astrophysics Data System (ADS)

    Horváth, D. X.; Sotiriadis, S.; Takács, G.

    2016-01-01

    We consider the problem of determining the initial state of integrable quantum field theory quenches in terms of the post-quench eigenstates. The corresponding overlaps are a fundamental input to most exact methods to treat integrable quantum quenches. We construct and examine an infinite integral equation hierarchy based on the form factor bootstrap, proposed earlier as a set of conditions determining the overlaps. Using quenches of the mass and interaction in Sinh-Gordon theory as a concrete example, we present theoretical arguments that the state has the squeezed coherent form expected for integrable quenches, and supporting an Ansatz for the solution of the hierarchy. Moreover we also develop an iterative method to solve numerically the lowest equation of the hierarchy. The iterative solution along with extensive numerical checks performed using the next equation of the hierarchy provides a strong numerical evidence that the proposed Ansatz gives a very good approximation for the solution.

  1. The Glory Program: Global Science from a Unique Spacecraft Integration

    NASA Technical Reports Server (NTRS)

    Bajpayee Jaya; Durham, Darcie; Ichkawich, Thomas

    2006-01-01

    The Glory program is an Earth and Solar science mission designed to broaden science community knowledge of the environment. The causes and effects of global warming have become a concern in recent years and Glory aims to contribute to the knowledge base of the science community. Glory is designed for two functions: one is solar viewing to monitor the total solar irradiance and the other is observing the Earth s atmosphere for aerosol composition. The former is done with an active cavity radiometer, while the latter is accomplished with an aerosol polarimeter sensor to discern atmospheric particles. The Glory program is managed by NASA Goddard Space Flight Center (GSFC) with Orbital Sciences in Dulles, VA as the prime contractor for the spacecraft bus, mission operations, and ground system. This paper will describe some of the more unique features of the Glory program including the integration and testing of the satellite and instruments as well as the science data processing. The spacecraft integration and test approach requires extensive analysis and additional planning to ensure existing components are successfully functioning with the new Glory components. The science mission data analysis requires development of mission unique processing systems and algorithms. Science data analysis and distribution will utilize our national assets at the Goddard Institute for Space Studies (GISS) and the University of Colorado's Laboratory for Atmospheric and Space Physics (LASP). The Satellite was originally designed and built for the Vegetation Canopy Lidar (VCL) mission, which was terminated in the middle of integration and testing due to payload development issues. The bus was then placed in secure storage in 2001 and removed from an environmentally controlled container in late 2003 to be refurbished to meet the Glory program requirements. Functional testing of all the components was done as a system at the start of the program, very different from a traditional program

  2. Crossover from BCS to Bose superconductivity: A functional integral approach

    SciTech Connect

    Randeria, M.; Sa de Melo, C.A.R.; Engelbrecht, J.R.

    1993-04-01

    We use a functional integral formulation to study the crossover from cooperative Cooper pairing to the formation and condensation of tightly bound pairs in a 3D continuum model of fermions with attractive interactions. The inadequacy of a saddle point approximation with increasing coupling is pointed out, and the importance of temporal (quantum) fluctuations for normal state properties at intermediate and strong coupling is emphasized. In addition to recovering the Nozieres-Schmitt-Pink interpolation scheme for T{sub c}, and the Leggett variational results for T = 0, we also present results for evolution of the time-dependent Ginzburg-Landau equation and collective mode spectrum as a function of the coupling.

  3. Spectral duality in integrable systems from AGT conjecture

    NASA Astrophysics Data System (ADS)

    Mironov, A.; Morozov, A.; Zenkevich, Y.; Zotov, A.

    2013-03-01

    We describe relationships between integrable systems with N degrees of freedom arising from the Alday-Gaiotto-Tachikawa conjecture. Namely, we prove the equivalence (spectral duality) between the N-cite Heisenberg spin chain and a reduced gl N Gaudin model both at classical and quantum level. The former one appears on the gauge theory side of the Alday-Gaiotto-Tachikawa relation in the Nekrasov-Shatashvili (and further the Seiberg-Witten) limit while the latter one is natural on the CFT side. At the classical level, the duality transformation relates the Seiberg-Witten differentials and spectral curves via a bispectral involution. The quantum duality extends this to the equivalence of the corresponding Baxter-Schrödinger equations (quantum spectral curves). This equivalence generalizes both the spectral self-duality between the 2 × 2 and N × N representations of the Toda chain and the famous Adams-Harnad-Hurtubise duality.

  4. Spacelab - From early integration to first flight. I

    NASA Astrophysics Data System (ADS)

    Thirkettle, A.; di Mauro, F.; Stephens, R.

    1984-05-01

    Spacelab is a series of flight elements that can be assembled together in different configurations. The laboratory is designed to accommodate many payloads with totally different characteristics. Two models were built: one was tested functionally, integrated into an Engineering Model and delivered to NASA. The other was used for subsystem testing. The Spacelab system consists of several functional elements within the Module, Igloo and Pallet structures: an Electric Power Distribution Subsystem, a Command and Data Management Subsystem, Software, Caution-and-Warning Subsystem and an Environmental Control Subsystem. The Engineering Model tests were conducted in Europe from April 1978 through October 1980, delivery of the laboratory to JFK Space Center, Florida was in December 1980, and the first flight was made in November 1983 on Space Shuttle STS-9.

  5. Genic insights from integrated human proteomics in GeneCards.

    PubMed

    Fishilevich, Simon; Zimmerman, Shahar; Kohn, Asher; Iny Stein, Tsippi; Olender, Tsviya; Kolker, Eugene; Safran, Marilyn; Lancet, Doron

    2016-01-01

    GeneCards is a one-stop shop for searchable human gene annotations (http://www.genecards.org/). Data are automatically mined from ∼120 sources and presented in an integrated web card for every human gene. We report the application of recent advances in proteomics to enhance gene annotation and classification in GeneCards. First, we constructed the Human Integrated Protein Expression Database (HIPED), a unified database of protein abundance in human tissues, based on the publically available mass spectrometry (MS)-based proteomics sources ProteomicsDB, Multi-Omics Profiling Expression Database, Protein Abundance Across Organisms and The MaxQuant DataBase. The integrated database, residing within GeneCards, compares favourably with its individual sources, covering nearly 90% of human protein-coding genes. For gene annotation and comparisons, we first defined a protein expression vector for each gene, based on normalized abundances in 69 normal human tissues. This vector is portrayed in the GeneCards expression section as a bar graph, allowing visual inspection and comparison. These data are juxtaposed with transcriptome bar graphs. Using the protein expression vectors, we further defined a pairwise metric that helps assess expression-based pairwise proximity. This new metric for finding functional partners complements eight others, including sharing of pathways, gene ontology (GO) terms and domains, implemented in the GeneCards Suite. In parallel, we calculated proteome-based differential expression, highlighting a subset of tissues that overexpress a gene and subserving gene classification. This textual annotation allows users of VarElect, the suite's next-generation phenotyper, to more effectively discover causative disease variants. Finally, we define the protein-RNA expression ratio and correlation as yet another attribute of every gene in each tissue, adding further annotative information. The results constitute a significant enhancement of several Gene

  6. Genic insights from integrated human proteomics in GeneCards

    PubMed Central

    Fishilevich, Simon; Zimmerman, Shahar; Kohn, Asher; Iny Stein, Tsippi; Olender, Tsviya; Kolker, Eugene; Safran, Marilyn; Lancet, Doron

    2016-01-01

    GeneCards is a one-stop shop for searchable human gene annotations (http://www.genecards.org/). Data are automatically mined from ∼120 sources and presented in an integrated web card for every human gene. We report the application of recent advances in proteomics to enhance gene annotation and classification in GeneCards. First, we constructed the Human Integrated Protein Expression Database (HIPED), a unified database of protein abundance in human tissues, based on the publically available mass spectrometry (MS)-based proteomics sources ProteomicsDB, Multi-Omics Profiling Expression Database, Protein Abundance Across Organisms and The MaxQuant DataBase. The integrated database, residing within GeneCards, compares favourably with its individual sources, covering nearly 90% of human protein-coding genes. For gene annotation and comparisons, we first defined a protein expression vector for each gene, based on normalized abundances in 69 normal human tissues. This vector is portrayed in the GeneCards expression section as a bar graph, allowing visual inspection and comparison. These data are juxtaposed with transcriptome bar graphs. Using the protein expression vectors, we further defined a pairwise metric that helps assess expression-based pairwise proximity. This new metric for finding functional partners complements eight others, including sharing of pathways, gene ontology (GO) terms and domains, implemented in the GeneCards Suite. In parallel, we calculated proteome-based differential expression, highlighting a subset of tissues that overexpress a gene and subserving gene classification. This textual annotation allows users of VarElect, the suite’s next-generation phenotyper, to more effectively discover causative disease variants. Finally, we define the protein–RNA expression ratio and correlation as yet another attribute of every gene in each tissue, adding further annotative information. The results constitute a significant enhancement of several Gene

  7. NASICs: A 'fabric-centric' approach towards integrated nanosystems

    NASA Astrophysics Data System (ADS)

    Narayanan, Pritish

    This dissertation addresses the fundamental problem of how to build computing systems for the nanoscale. With CMOS reaching fundamental limits, emerging nanomaterials such as semiconductor nanowires, carbon nanotubes, graphene etc. have been proposed as promising alternatives. However, nanoelectronics research has largely focused on a 'device-first' mindset without adequately addressing system-level capabilities, challenges for integration and scalable assembly. In this dissertation, we propose to develop an integrated nano-fabric, (broadly defined as nanostructures/devices in conjunction with paradigms for assembly, interconnection and circuit styles), as opposed to approaches that focus on MOSFET replacement devices as the ultimate goal. In the 'fabric-centric' mindset, design choices at individual levels are made compatible with the fabric as a whole and minimize challenges for nanomanufacturing while achieving system-level benefits vs. scaled CMOS. We present semiconductor nanowire based nano-fabrics incorporating these fabric-centric principles called NASICs and N3ASICs and discuss how we have taken them from initial design to experimental prototype. Manufacturing challenges are mitigated through careful design choices at multiple levels of abstraction. Regular fabrics with limited customization mitigate overlay alignment requirements. Cross-nanowire FET devices and interconnect are assembled together as part of the uniform regular fabric without the need for arbitrary fine-grain interconnection at the nanoscale, routing or device sizing. Unconventional circuit styles are devised that are compatible with regular fabric layouts and eliminate the requirement for using complementary devices. Core fabric concepts are introduced and validated. Detailed analyses on device-circuit co-design and optimization, cascading, noise and parameter variation are presented. Benchmarking of nanowire processor designs vs. equivalent scaled 16nm CMOS shows up to 22X area, 30X

  8. Flow units from integrated WFT and NMR data

    SciTech Connect

    Kasap, E.; Altunbay, M.; Georgi, D.

    1997-08-01

    Reliable and continuous permeability profiles are vital as both hard and soft data required for delineating reservoir architecture. They can improve the vertical resolution of seismic data, well-to-well stratigraphic correlations, and kriging between the well locations. In conditional simulations, permeability profiles are imposed as the conditioning data. Variograms, covariance functions and other geostatistical indicators are more reliable when based on good quality permeability data. Nuclear Magnetic Resonance (NMR) logging and Wireline Formation Tests (WFT) separately generate a wealth of information, and their synthesis extends the value of this information further by providing continuous and accurate permeability profiles without increasing the cost. NMR and WFT data present a unique combination because WFTs provide discrete, in situ permeability based on fluid-flow, whilst NMR responds to the fluids in the pore space and yields effective porosity, pore-size distribution, bound and moveable fluid saturations, and permeability. The NMR permeability is derived from the T{sub 2}-distribution data. Several equations have been proposed to transform T{sub 2} data to permeability. Regardless of the transform model used, the NMR-derived permeabilities depend on interpretation parameters that may be rock specific. The objective of this study is to integrate WFT permeabilities with NMR-derived, T{sub 2} distribution-based permeabilities and thereby arrive at core quality, continuously measured permeability profiles. We outlined the procedures to integrate NMR and WFT data and applied the procedure to a field case. Finally, this study advocates the use of hydraulic unit concepts to extend the WFT-NMR derived, core quality permeabilities to uncored intervals or uncored wells.

  9. Monolithic Integrated Radiation Sensor Using Stimulated Luminescence From Alumina

    NASA Technical Reports Server (NTRS)

    McKeever, S. W. S.; Yukihara, E. G.; Stoebe, T. G.; Chen, T.-C.

    2005-01-01

    The project goal was to design and test a monolithic integrated device for radiation sensing, using optically stimulated luminescence (OSL) from Al2O3:C. The device would consist of GaN/InGaN-based components epitaxially grown on each side of a A12O3:C substrate. Radiation energy stored in the substrate would be stimulated by visible emission from a GaN light-emitting diode (LED) grown on one side of the device, and the OSL emission from the substrate (in the blue region of the spectrum) would be detected by the InGaN pi-n diode grown on the other side of the substrate. The primary application of the device would be in space radiation environments. Thus, two major research thrusts were launched during this project. Firstly, research at Oklahoma State University (Dr. Stephen W.S. McKeever and Dr. E.G. Yukihara) concentrated on characterization of the OSL properties of Al2O3:C in radiation fields typical of those experienced in low-Earth orbit. Secondly, research at the University of Washington (Co-Is, Dr. T.G. Stoebe and Dr. T. Chen) focused of device development and GaN/InGaN epitaxial growth. While progress in each line of research has been substantial, the ultimate goal (that of producing a working prototype device) has not yet been reached. We detail the research progress and identify outstanding issues in this paper.

  10. From All Walks of Life: New Hope for School Integration

    ERIC Educational Resources Information Center

    Kahlenberg, Richard D.

    2013-01-01

    Integrating our schools is a goal that many of us share. But some seem to have given up on the idea, as plans to boost racial diversity have come under attack, and as the fixation on test scores has narrowed some people's concept of a good education. There is, however, new hope: integration by socioeconomic status. It's a cost-effective, legally…

  11. Five Ways to Integrate: Using Strategies from Contemporary Art

    ERIC Educational Resources Information Center

    Marshall, Julia

    2010-01-01

    This article is for art teachers of all levels who want to teach through art and about art. The purpose of this article is twofold. It provides evidence that integration is a significant, lively and authentic art practice today and, therefore, studying about art and integrating it are compatible. It also offers teachers and students in elementary,…

  12. Artistic Technology Integration: Stories From Primary and Elementary Classrooms

    ERIC Educational Resources Information Center

    Steckel, Barbara; Shinas, Valerie Harlow; Van Vaerenewyck, Leah

    2015-01-01

    The purpose of this article is to inform teachers about the ways technology can be integrated to add value to literacy instruction. Artistic technology-integrated literacy and disciplinary instruction in preK through grade 4 classrooms is described through the stories of five teachers who were identified as both strong teachers of literacy and…

  13. Multisensory integration in complete unawareness: evidence from audiovisual congruency priming.

    PubMed

    Faivre, Nathan; Mudrik, Liad; Schwartz, Naama; Koch, Christof

    2014-11-01

    Multisensory integration is thought to require conscious perception. Although previous studies have shown that an invisible stimulus could be integrated with an audible one, none have demonstrated integration of two subliminal stimuli of different modalities. Here, pairs of identical or different audiovisual target letters (the sound /b/ with the written letter "b" or "m," respectively) were preceded by pairs of masked identical or different audiovisual prime digits (the sound /6/ with the written digit "6" or "8," respectively). In three experiments, awareness of the audiovisual digit primes was manipulated, such that participants were either unaware of the visual digit, the auditory digit, or both. Priming of the semantic relations between the auditory and visual digits was found in all experiments. Moreover, a further experiment showed that unconscious multisensory integration was not obtained when participants did not undergo prior conscious training of the task. This suggests that following conscious learning, unconscious processing suffices for multisensory integration. PMID:25269620

  14. Alkane production from biomass: chemo-, bio- and integrated catalytic approaches.

    PubMed

    Deneyer, Aron; Renders, Tom; Van Aelst, Joost; Van den Bosch, Sander; Gabriëls, Dries; Sels, Bert F

    2015-12-01

    Linear, branched and cyclic alkanes are important intermediates and end products of the chemical industry and are nowadays mainly obtained from fossil resources. In search for alternatives, biomass feedstocks are often presented as a renewable carbon source for the production of fuels, chemicals and materials. However, providing a complete market for all these applications seems unrealistic due to both financial and logistic issues. Despite the very large scale of current alkane-based fuel applications, biomass definitely has the potential to offer a partial solution to the fuel business. For the smaller market of chemicals and materials, a transition to biomass as main carbon source is more realistic and even probably unavoidable in the long term. The appropriate use and further development of integrated chemo- and biotechnological (catalytic) process strategies will be crucial to successfully accomplish this petro-to-bio feedstock transition. Furthermore, a selection of the most promising technologies from the available chemo- and biocatalytic tool box is presented. New opportunities will certainly arise when multidisciplinary approaches are further explored in the future. In an attempt to select the most appropriate biomass sources for each specific alkane-based application, a diagram inspired by van Krevelen is applied, taking into account both the C-number and the relative functionality of the product molecules. PMID:26360875

  15. Consumer motivation towards purchasing fruit from integrated production in Belgium.

    PubMed

    Vannoppen, J; Verbeke, W; Van Huylenbroeck, G

    2001-01-01

    Consumer concerns about food safety have been steadily growing during the last decade. Along with the recognition of the increasing power from the consumer side of food chains, this has forced agricultural producers to innovate and adapt their production methods. One of those developments is integrated production of pip fruit (IFP). This research analyses and presents motivational structures of consumers towards purchasing IP fruit in Belgium. The research methodology builds on means-end-chain (MEC) theory, with data collected through personal laddering interviews with consumers. A hierarchical value map, indicating motivational structures for farm shop purchase of IP-labelled apples, is presented. IP-apple buyers pursue typical values, with health being paramount. The findings reveal interactions between market channel characteristics and product attributes, including characteristics that refer to production methods. Also, the study shows how outlet choice influences the perception and the motivation structure of the respondents for the specific product, fresh fruit in this case. From the findings, two sets of implications are set forth. First, marketing implications pertaining to advertising through the application of the "Means-End Conceptualization of the Components of Advertising Strategy" or MECCAS model. Second, implications to producers with respect to adapting their production methods to the needs and wants of the present end consumers. PMID:12425106

  16. Selecta from a Life-Long Obsession with Path Integrals

    SciTech Connect

    Klauder, John R.

    2008-06-18

    The definition and interpretation of canonical, phase space path integrals has evolved over many years to achieve a form that now admits a correct and rigorous formulation, which is also covariant under canonical coordinate transformations. Such formulations involve coherent state representations, which, in their modern version, were originally introduced as an alternative tool to construct phase space path integrals. Moreover, coherent state representations lead to physical interpretations that are more natural than those afforded by more traditional representations. Suitable continuous time regularization procedures lead to a covariant phase space path integral formulation that greatly clarifies the vague phrase that canonical quantization requires Cartesian coordinates.

  17. Application of principles of integrated agricultural systems: results from farmer panels

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An Integrated Agricultural Systems working group comprised of USDA-ARS scientists is examining different agricultural systems from various geographic regions of the United States to determine fundamental principles that underlie successful integrated agricultural systems. Our hypothesis is that prin...

  18. Devices and Desires: Integrative Strategy Instruction from a Motivational Perspective.

    ERIC Educational Resources Information Center

    Vauras, Marja; And Others

    1993-01-01

    This critique of Edwin Ellis's Integrative Strategy Instruction model comments that analyses are needed concerning the mutual social adaptations of differently disposed (cognitively, motivationally, and emotionally) students with learning disabilities and teachers within the social frames of learning environments. (JDD)

  19. ATLAS from Data Research Associates: A Fully Integrated Automation System.

    ERIC Educational Resources Information Center

    Mellinger, Michael J.

    1987-01-01

    This detailed description of a fully integrated, turnkey library system includes a complete profile of the system (functions, operational characteristics, hardware, operating system, minimum memory and pricing); history of the technologies involved; and descriptions of customer services and availability. (CLB)

  20. A study on nanofabricated fully suspended graphene microribbons and their photophysics

    NASA Astrophysics Data System (ADS)

    Patil, Vikram

    Graphene exhibits extraordinary electrical, mechanical and optical properties which have attracted tremendous attention for applications in nanoelectronics, nanophotonics and novel sensor technologies. Properties such as wavelength-independent optical absorption and high carrier motilities are of particular interest for photodetection applications. While photodetectors made from mechanically exfoliated graphene are well reported in literature, a scalable approach, such as photodetectors made from chemical vapor deposition (CVD)-grown graphene, is highly desired from a practical standpoint. However, the photophysics of CVD-graphene involves complex mechanisms arising from inherent grain boundaries and defect levels, which are not well understood. Furthermore, the fabrication and characterization of suspended CVD-graphene structures are challenging, since they require the incorporation of several unique methodologies to create high performance photodetectors. This dissertation presents a study of CVD- graphene microribbons suspended between the metal contacts in photodetector applications. Several fabrication techniques, including larger-area CVD growth and polymer free transfer of monolayer graphene, full suspension of graphene microribbons and laser-current annealing, are utilized to obtain high-quality suspended graphene microribbons. In this study, Full suspension of CVD-graphene microribbons is found to enable four-fold improvement in photoresponse over substrate-supported microribbons, which is a significant step towards enhancing responsivity of future generation photodetectors. The photophysics of fully suspended graphene microribbons is analyzed using light-current input/output (L-I) analysis, which describes incident power dependent characteristics of photoelectric and/or photo-thermoelectric effects. From the analysis, it is found that the photoelectric effect dominates the photocurrent generation mechanism in fully suspended graphene, in contrast to the

  1. Audiovisual integration of emotional signals from others' social interactions.

    PubMed

    Piwek, Lukasz; Pollick, Frank; Petrini, Karin

    2015-01-01

    Audiovisual perception of emotions has been typically examined using displays of a solitary character (e.g., the face-voice and/or body-sound of one actor). However, in real life humans often face more complex multisensory social situations, involving more than one person. Here we ask if the audiovisual facilitation in emotion recognition previously found in simpler social situations extends to more complex and ecological situations. Stimuli consisting of the biological motion and voice of two interacting agents were used in two experiments. In Experiment 1, participants were presented with visual, auditory, auditory filtered/noisy, and audiovisual congruent and incongruent clips. We asked participants to judge whether the two agents were interacting happily or angrily. In Experiment 2, another group of participants repeated the same task, as in Experiment 1, while trying to ignore either the visual or the auditory information. The findings from both experiments indicate that when the reliability of the auditory cue was decreased participants weighted more the visual cue in their emotional judgments. This in turn translated in increased emotion recognition accuracy for the multisensory condition. Our findings thus point to a common mechanism of multisensory integration of emotional signals irrespective of social stimulus complexity. PMID:26005430

  2. Integrated bioethanol and protein production from brown seaweed Laminaria digitata.

    PubMed

    Hou, Xiaoru; Hansen, Jonas Høeg; Bjerre, Anne-Belinda

    2015-12-01

    A wild-growing glucose-rich (i.e. 56.7% glucose content) brown seaweed species Laminaria digitata, collected from the North Coast of Denmark in August 2012, was used as the feedstock for an integrated bioethanol and protein production. Glutamic acid and aspartic acid are the two most abundant amino acids in the algal protein, both with proportional content of 10% in crude protein. Only minor pretreatment of milling was used on the biomass to facilitate the subsequent enzymatic hydrolysis and fermentation. The Separate Hydrolysis and Fermentation (SHF) resulted in obviously higher ethanol yield than the Simultaneous Saccharification and Fermentation (SSF). High conversion rate at maximum of 84.1% glucose recovery by enzymatic hydrolysis and overall ethanol yield at maximum of 77.7% theoretical were achieved. Protein content in the solid residues after fermentation was enriched by 2.7 fold, with similar distributions of amino acids, due to the hydrolysis of polymers in the seaweed cell wall matrix. PMID:26342344

  3. Texas refiner optimizes by integrating units from idle plant

    SciTech Connect

    Rhodes, A.K.

    1995-03-20

    In 1993, Phibro Energy USA Inc. purchased Dow Chemical Co.`s idle 200,000 b/d refinery at Freeport, TX. The Dow facility, known as the Oyster Creek refinery, was incapable of producing gasoline, and therefore was somewhat incomplete as a stand-alone refinery. By relocating and integrating units from the Dow plant with Phibro`s 130,700 b/d refinery at Texas City, TX, and adding a new residual oil solvent extraction (ROSE) unit, Phibro will optimize its Texas refinery operations. The dismantling, movement, and re-erection phases of the project are all but finished, and installation of piping and new instrumentation for the major relocated units is well under way. When the project is complete, Phibro will drastically reduce fuel oil production at Texas City and increase output of middle distillate. Resid, which the company now produces in excess, will be converted to a heavy fluid catalytic cracking (FCC) feedstock. Most of this stream will be fed to the oversized FCC unit at Phibro`s 71,000 b/d Houston refinery, thus eliminating Phibro`s reliance on purchased FCC feed. The paper discusses the Oyster Creek refinery, the decision to reduce residual fuel oil production company-wide, building versus moving equipment, dismantling and transport, construction, products, operational changes, utilities, process wastes, regulations, preparations, and future prospects. The remaining equipment at Oyster Creek was sold to a South Korean refinery.

  4. Audiovisual integration of emotional signals from others' social interactions

    PubMed Central

    Piwek, Lukasz; Pollick, Frank; Petrini, Karin

    2015-01-01

    Audiovisual perception of emotions has been typically examined using displays of a solitary character (e.g., the face-voice and/or body-sound of one actor). However, in real life humans often face more complex multisensory social situations, involving more than one person. Here we ask if the audiovisual facilitation in emotion recognition previously found in simpler social situations extends to more complex and ecological situations. Stimuli consisting of the biological motion and voice of two interacting agents were used in two experiments. In Experiment 1, participants were presented with visual, auditory, auditory filtered/noisy, and audiovisual congruent and incongruent clips. We asked participants to judge whether the two agents were interacting happily or angrily. In Experiment 2, another group of participants repeated the same task, as in Experiment 1, while trying to ignore either the visual or the auditory information. The findings from both experiments indicate that when the reliability of the auditory cue was decreased participants weighted more the visual cue in their emotional judgments. This in turn translated in increased emotion recognition accuracy for the multisensory condition. Our findings thus point to a common mechanism of multisensory integration of emotional signals irrespective of social stimulus complexity. PMID:26005430

  5. The integrated Sachs-Wolfe signal from BOSS superstructures

    NASA Astrophysics Data System (ADS)

    Granett, B. R.; Kovács, A.; Hawken, A. J.

    2015-12-01

    Cosmic structures leave an imprint on the microwave background radiation through the integrated Sachs-Wolfe (ISW) effect. We construct a template map of the linear signal using the Sloan Digital Sky Survey-III Baryon Acoustic Oscillation Survey at redshift 0.43 < z < 0.65. We verify the imprint of this map on the Planck cosmic microwave background (CMB) temperature map at the 97 per cent confidence level and show consistency with the density-temperature cross-correlation measurement. Using this ISW reconstruction as a template, we investigate the presence of ISW sources and further examine the properties of the Granett-Neyrinck-Szapudi supervoid and supercluster catalogue. We characterize the three-dimensional density profiles of these structures for the first time and demonstrate that they are significant structures. Model fits demonstrate that the supervoids are elongated along the line of sight and we suggest that this special orientation may be picked out by the void-finding algorithm in photometric redshift space. We measure the mean temperature profiles in Planck maps from public void and cluster catalogues. In an attempt to maximize the stacked ISW signal, we construct a new catalogue of superstructures based upon local peaks and troughs of the gravitational potential. However, we do not find a significant correlation between these structures and the CMB temperature.

  6. From The Lab to The Fab: Transistors to Integrated Circuits

    NASA Astrophysics Data System (ADS)

    Huff, Howard R.

    2003-09-01

    Transistor action was experimentally observed by John Bardeen and Walter Brattain in n-type polycrystalline germanium on December 16, 1947 (and subsequently polycrystalline silicon) as a result of the judicious placement of gold-plated probe tips in nearby single crystal grains of the polycrystalline material (i.e., the point-contact semiconductor amplifier, often referred to as the point-contact transistor).The device configuration exploited the inversion layer as the channel through which most of the emitted (minority) carriers were transported from the emitter to the collector. The point-contact transistor was manufactured for ten years starting in 1951 by the Western Electric Division of AT&T. The a priori tuning of the point-contact transistor parameters, however, was not simple inasmuch as the device was dependent on the detailed surface structure and, therefore, very sensitive to humidity and temperature as well as exhibiting high noise levels. Accordingly, the devices differed significantly in their characteristics and electrical instabilities leading to "burnout" were not uncommon. With the implementation of crystalline semiconductor materials in the early 1950s, however, p-n junction (bulk) transistors began replacing the point-contact transistor, silicon began replacing germanium and the transfer of transistor technology from the lab to the lab accelerated. We shall review the historical route by which single crystalline materials were developed and the accompanying methodologies of transistor fabrication, leading to the onset of the Integrated Circuit (IC) era. Finally, highlights of the early years of the IC era will be reviewed from the 256 bit through the 4M DRAM. Elements of IC scaling and the role of Moore's Law in setting the parameters by which the IC industry's growth was monitored will be discussed.

  7. Whither Integrated Assessment? Reflections from the Leading Edge

    SciTech Connect

    Pitcher, Hugh M.; Stokes, Gerald M.; Malone, Elizabeth L.

    2007-12-01

    After ten years of Climate Change Impacts and Integrated Assessment (CCIIA) workshops under the aegis of the Energy Modeling Forum (EMF), it is appropriate to consider what progress has been made and what additional tasks confront us. The breadth and scope of the papers in this volume provide ample evidence of the progress. In this paper we consider the additional tasks before us as a community interested in applying integrated assessment to a wide range of research and policy issues.

  8. Atomic-Level Sculpting of Crystalline Oxides: Toward Bulk Nanofabrication with Single Atomic Plane Precision.

    PubMed

    Jesse, Stephen; He, Qian; Lupini, Andrew R; Leonard, Donovan N; Oxley, Mark P; Ovchinnikov, Oleg; Unocic, Raymond R; Tselev, Alexander; Fuentes-Cabrera, Miguel; Sumpter, Bobby G; Pennycook, Stephen J; Kalinin, Sergei V; Borisevich, Albina Y

    2015-11-25

    The atomic-level sculpting of 3D crystalline oxide nanostructures from metastable amorphous films in a scanning transmission electron microscope (STEM) is demonstrated. Strontium titanate nanostructures grow epitaxially from the crystalline substrate following the beam path. This method can be used for fabricating crystalline structures as small as 1-2 nm and the process can be observed in situ with atomic resolution. The fabrication of arbitrary shape structures via control of the position and scan speed of the electron beam is further demonstrated. Combined with broad availability of the atomic resolved electron microscopy platforms, these observations suggest the feasibility of large scale implementation of bulk atomic-level fabrication as a new enabling tool of nanoscience and technology, providing a bottom-up, atomic-level complement to 3D printing. PMID:26478983

  9. Atomic-Level Sculpting of Crystalline Oxides: Toward Bulk Nanofabrication with Single Atomic Plane Precision

    SciTech Connect

    Jesse, Stephen; He, Qian; Lupini, Andrew R.; Leonard, Donovan N.; Oxley, Mark P.; Ovchinnikov, Oleg; Unocic, Raymond R.; Tselev, Alexander; Fuentes-Cabrera, Miguel; Sumpter, Bobby G.; Pennycook, Stephen J.; Kalinin, Sergei V.; Borisevich, Albina Y.

    2015-10-19

    We demonstrate atomic-level sculpting of 3D crystalline oxide nanostructures from metastable amorphous layer in a scanning transmission electron microscope (STEM). Strontium titanate nanostructures grow epitaxially from the crystalline substrate following the beam path. This method can be used for fabricating crystalline structures as small as 1-2 nm and the process can be observed in situ with atomic resolution. We further demonstrate fabrication of arbitrary shape structures via control of the position and scan speed of the electron beam. Combined with broad availability of the atomic resolved electron microscopy platforms, these observations suggest the feasibility of large scale implementation of bulk atomic-level fabrication as a new enabling tool of nanoscience and technology, providing a bottom-up, atomic-level complement to 3D printing.

  10. Billiard simulation and FFT analysis of AAS oscillations in nanofabricated InGaAs

    NASA Astrophysics Data System (ADS)

    Koga, Takaaki; Faniel, Sebastien; Mineshige, Shunsuke; Matsuura, Toru; Sekine, Yoshiaki

    2010-03-01

    Gate-voltage-dependent amplitude of magneto-conductance oscillation was analyzed using FFT method. The obtained FFT spectrum was compared with the areal dependence of the occurrence and spin interferece amplitude, calculated for Altshuler-Aronov-Spivak (AAS) type time-reversal pairs of the interference paths on all possible classical trajectroies that were obtained by extensive billiard simulations within the given structures. We have calcuated generic spin interference (SI) curves as a function of the Rashba parameter α, for various values of the Dresselhaus parameter b41^6c6c [eVå^3]. The comparison between theory and experiment suggested that the value of b41^6c6c should be considerably reduced from 27 eVå^3, the generally known value from the k.p theory.

  11. Atomic-Level Sculpting of Crystalline Oxides: Toward Bulk Nanofabrication with Single Atomic Plane Precision

    DOE PAGESBeta

    Jesse, Stephen; He, Qian; Lupini, Andrew R.; Leonard, Donovan N.; Oxley, Mark P.; Ovchinnikov, Oleg; Unocic, Raymond R.; Tselev, Alexander; Fuentes-Cabrera, Miguel; Sumpter, Bobby G.; et al

    2015-10-19

    We demonstrate atomic-level sculpting of 3D crystalline oxide nanostructures from metastable amorphous layer in a scanning transmission electron microscope (STEM). Strontium titanate nanostructures grow epitaxially from the crystalline substrate following the beam path. This method can be used for fabricating crystalline structures as small as 1-2 nm and the process can be observed in situ with atomic resolution. We further demonstrate fabrication of arbitrary shape structures via control of the position and scan speed of the electron beam. Combined with broad availability of the atomic resolved electron microscopy platforms, these observations suggest the feasibility of large scale implementation of bulkmore » atomic-level fabrication as a new enabling tool of nanoscience and technology, providing a bottom-up, atomic-level complement to 3D printing.« less

  12. Nanofabrication and Detection of Molecular Shuttles powered by Kinesin Motor Proteins

    NASA Astrophysics Data System (ADS)

    Oliveira, Daniel; Domyoung, Kim; Umetsu, Mitsuo; Adschiri, Tadafumi; Teizer, Winfried

    2011-03-01

    The intracellular cargo delivery performed by kinesin motor proteins can be biomimetically employed to engineer tailor-made artificial nanotransport systems. Kinesin (expressed on an Escherichia coli system) and microtubules (obtained from the polymerization of tubulin proteins) were prepared and characterized. We report recent results and explore the aim of the construction of Nanoelectromechanical Systems and their potential applications, e.g. as drug delivery systems. This work was supported by the WPI Program.

  13. Nanofabrication of highly ordered, tunable metallic mesostructures via quasi-hard-templating of lyotropic liquid crystals

    PubMed Central

    Zhang, Xinyi; Lu, Wei; Dai, Jiyan; Bourgeois, Laure; Yao, Jianfeng; Wang, Huanting; Friend, James R.; Zhao, Dongyuan; MacFarlane, Douglas R.

    2014-01-01

    The synthesis of metal frameworks perforated with nanotunnels is a challenge because metals have high surface energies that favor low surface area structures; traditional liquid-crystal templating techniques cannot achieve the synthetic control required. We report a synthetic strategy to fabricate metal nanomaterials with highly ordered, tunable mesostructures in confined systems based on a new quasi-hard-templating liquid-crystals mechanism. The resulting platinum nanowires exhibit long range two-dimensional hexagonally ordered mesopore structures. In addition, single crystalline hexagonal mesoporous platinum nanowires with dominant {110} facets have been synthesized. Finally, we demonstrate that the mesostructures of metal nanomaterials can be tuned from hexagonal to lamellar mesostructures. PMID:25502015

  14. Controlled chattering—a new 'cutting-edge' technology for nanofabrication

    NASA Astrophysics Data System (ADS)

    Gu, Hongyan; Zhang, Junwei; Faucher, Santiago; Zhu, Shiping

    2010-09-01

    Chatters are unwanted random defects on surfaces often generated in cutting samples via microtome for micrographic analysis. In this work, we demonstrate that chatters can actually be controlled for fabrication of uniform periodic wavy patterns on polymethylmethacrylate surfaces. This control in chattering is achieved based on an oscillation cutting mechanism. Pattern sizes ranging from 30 nm to a few micrometers are obtained by fine-tuning cutting speed and oscillating frequency. This simple one-step non-lithographic 'cutting-edge' technology is simple and robust, with no chemical reactions and by-products involved and ease in scaling up for long-range and large-areas patterns.

  15. Theoretical Application of Irreversible (Nonequilibrium) Thermodynamic Principles to Enhance Solute Fluxes across Nanofabricated Hemodialysis Membranes

    PubMed Central

    Hedayat, Assem; Elmoselhi, Hamdi; Shoker, Ahmed

    2012-01-01

    Objective. Nanotechnology has the potential to improve hemodialysis membrane technology. Thus, a major objective is to understand how to enhance toxic solute fluxes across these membranes. The aim of this concept building study is to review the application of irreversible thermodynamic (IT) to solute fluxes. Methods. We expanded the application of the Nernst-Planck equation to include the Kedem-Katchalsky equation, pH, membrane thickness, pore size, and electric potential as variables. Results. (1) Reducing the membrane's thickness from 25 μm to 25 nm increased the flux of creatinine, β2-microglobulin, and tumor necrosis factor-α (TNF-α) by a thousand times but prevented completely albumin flux, (2) applying an electric potential of 50–400 mV across the membrane enhanced the flux of the respective molecules by 71.167 × 10−3, 38.7905 × 10−8, and 0.595 × 10−13 mol/s, and (3) changing the pH from 7.35 to 7.42 altered the fluxes minimally. Conclusions. The results supported an argument to investigate the application of IT to study forces of fluxes across membranes. Reducing the membrane's thickness—together with the application of an electrical potential—qualities achievable by nanotechnology, can enhance the removal of uremic toxins by many folds. However, changing the pH at a specific membrane thickness does not affect the flux significantly. PMID:23209903

  16. Reinforcement of osteogenesis with nanofabricated hydroxyapatite and GelMA nanocomposite

    NASA Astrophysics Data System (ADS)

    Meng, Zhaokai; Chitrakar, Chandani; Gaharwar, Akhilesh K.; Yakovlev, Vladislav V.

    2015-02-01

    Every year in the United States approximately 1.5 million people are suffering from bone fractures. Current treatment solutions include surgeries and grafting process; however, it does not show any osteoconductive action, which is an essential character for biomaterials. The main objective of the reported studies is to develop a novel nanocomposite comprising of hydroxyapatite nanospheres (~40nm) and gelatin methacrylate to promote bone regeneration without any osteoinductive factors. To validate our hypothesis that chemical and mechanical properties of nanocomposite get enhanced, we employed various characterization techniques including Brillouin and Raman spectroscopies. The results imply that hydroxyaoatite nanoparticles are capable of enhancing the macroscopic stiffness at the structural level. To the contrary, Brillouin spectroscopy suggests that the microscopic elasticity of the nanocomposite was weakened.

  17. Multiple display of catalytic modules on a protein scaffold: nano-fabrication of enzyme particles.

    PubMed

    Heyman, Arnon; Barak, Yoav; Caspi, Jonathan; Wilson, David B; Altman, Arie; Bayer, Edward A; Shoseyov, Oded

    2007-09-30

    Self assembly is a prerequisite for fabricating nanoscale structures. Here we present a new fusion protein based on the stress-responsive homo-oligomeric protein, SP1. This ring-shaped protein is a highly stable homododecamer, which can be potentially utilized to self-assemble different modules and enzymes in a predicted and oriented manner. For that purpose, a cohesin module (a component of the bacterial cellulosome) was selected, its gene fused in-frame to SP1, and the fusion protein was expressed in Escherichia coli. The cohesin module, specialized to incorporate different enzymes through specific recognition of a dockerin modular counterpart, is used to display new moieties on the SP1 scaffold. The SP1 scaffold displayed 12 active cohesin modules and specific binding to a dockerin-fused cellulase enzyme from Thermobifida fusca. Moreover, we found a significant increase in specific activity of the scaffold-displayed enzymes. PMID:17826857

  18. NanoLiterBioReactor: long-term mammalian cell culture at nanofabricated scale.

    PubMed

    Prokop, Ales; Prokop, Zdenka; Schaffer, David; Kozlov, Eugene; Wikswo, John; Cliffel, David; Baudenbacher, Franz

    2004-12-01

    There is a need for microminiaturized cell-culture environments, i.e. NanoLiter BioReactors (NBRs), for growing and maintaining populations of up to several hundred cultured mammalian cells in volumes three orders of magnitude smaller than those contained in standard multi-well screening plates. These devices would enable the development of a new class of miniature, automated cell-based bioanalysis arrays for monitoring the immediate environment of multiple cell lines and assessing the effects of drug or toxin exposure. We fabricated NBR prototypes, each of which incorporates a culture chamber, inlet and outlet ports, and connecting microfluidic conduits. The fluidic components were molded in polydimethylsiloxane (PDMS) using soft-lithography techniques, and sealed via plasma activation against a glass slide, which served as the primary culture substrate in the NBR. The input and outlet ports were punched into the PDMS block, and enabled the supply and withdrawal of culture medium into/from the culture chamber (10-100 nL volume), as well as cell seeding. Because of the intrinsically high oxygen permeability of the PDMS material, no additional CO(2)/air supply was necessary. The developmental process for the NBR typically employed several iterations of the following steps: Conceptual design, mask generation, photolithography, soft lithography, and proof-of-concept culture assay. We have arrived at several intermediate designs. One is termed "circular NBR with a central post (CP-NBR)," another, "perfusion (grid) NBR (PG-NBR)," and a third version, "multitrap (cage) NBR (MT-NBR)," the last two providing total cell retention. Three cells lines were tested in detail: a fibroblast cell line, CHO cells, and hepatocytes. Prior to the culturing trials, extensive biocompatibility tests were performed on all materials to be employed in the NBR design. To delineate the effect of cell seeding density on cell viability and survival, we conducted separate plating experiments

  19. Nanofabrication of Gate-defined GaAs/AlGaAs Lateral Quantum Dots

    PubMed Central

    Bureau-Oxton, Chloé; Camirand Lemyre, Julien; Pioro-Ladrière, Michel

    2013-01-01

    A quantum computer is a computer composed of quantum bits (qubits) that takes advantage of quantum effects, such as superposition of states and entanglement, to solve certain problems exponentially faster than with the best known algorithms on a classical computer. Gate-defined lateral quantum dots on GaAs/AlGaAs are one of many avenues explored for the implementation of a qubit. When properly fabricated, such a device is able to trap a small number of electrons in a certain region of space. The spin states of these electrons can then be used to implement the logical 0 and 1 of the quantum bit. Given the nanometer scale of these quantum dots, cleanroom facilities offering specialized equipment- such as scanning electron microscopes and e-beam evaporators- are required for their fabrication. Great care must be taken throughout the fabrication process to maintain cleanliness of the sample surface and to avoid damaging the fragile gates of the structure. This paper presents the detailed fabrication protocol of gate-defined lateral quantum dots from the wafer to a working device. Characterization methods and representative results are also briefly discussed. Although this paper concentrates on double quantum dots, the fabrication process remains the same for single or triple dots or even arrays of quantum dots. Moreover, the protocol can be adapted to fabricate lateral quantum dots on other substrates, such as Si/SiGe. PMID:24300661

  20. Nanofabrication and characterization of PVA-organofiller/Ag nanocoatings on pMAD plasmids

    NASA Astrophysics Data System (ADS)

    Erdonmez, D.; Mosayyebi, S.; Erkan, K.; Salimi, K.; Nagizade, N.; Saglam, N.; Rzayev, Z. M. O.

    2014-11-01

    Nowadays, the most important problem in microbial researches is bacterial resistance which is carried out by DNA plasmids against antibacterial agents. The effect of antibacterial nanoparticles on bacteria is remarkable, but studies on the interactions of these particles with plasmids do not search or there are no adequate studies. We proposed that the nanoparticles, which are disrupted the self-assembled structure of plasmids, may decrease the resistance of bacteria, and therefore, increase the activity of utilized antibacterial agents. In this work, we synthesized polymer nanofiber webs samples by electrospinning technique from pure water solution of nanocomposites with different contents of silver nanoparticles, and surface morphology of nanofibers composites were characterized by SEM microscopy. Their interactions with pMAD DNA plasmids were investigated. It was demonstrated that the synthesized Ag-carrying nanohybrid composites with higher surface contacted areas were significantly inhibited the activity of plasmid DNA against bacterial resistance. Agreeing with obtained results, synthesized nanofiber coatings can be recommended for the widely applications in nanobiotechnology, nanomedicine, and bioengineering processing.

  1. Nanofabrication at 1nm resolution by quantum optical lithography (Presentation Recording)

    NASA Astrophysics Data System (ADS)

    Pavel, Eugen

    2015-08-01

    A major problem in the optical lithography was the diffraction limit. Here, we report and demonstrate a lithography method, Quantum Optical Lithography [1,2], able to attain 1 nm resolution by optical means using new materials (fluorescent photosensitive glass-ceramics and QMC-5 resist). The performance is several times better than that described for any optical or Electron Beam Lithography (EBL) methods. In Fig. 1 we present TEM images of 1 nm lines recorded at 9.6 m/s. a) b) Fig. 1 TEM images of: a) multiple 1 nm lines written in a fluorescent photosensitive glass-ceramics sample; b) single 1 nm line written in QMC-5 resist. References [1] E. Pavel, S. Jinga, B.S. Vasile, A. Dinescu, V. Marinescu, R. Trusca and N. Tosa, "Quantum Optical Lithography from 1 nm resolution to pattern transfer on silicon wafer", Optics and Laser Technology, 60 (2014) 80-84. [2] E. Pavel, S. Jinga, E. Andronescu, B.S. Vasile, G. Kada, A. Sasahara, N. Tosa, A. Matei, M. Dinescu, A. Dinescu and O.R. Vasile, "2 nm Quantum Optical Lithography", Optics Communications,291 (2013) 259-263

  2. Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect

    PubMed Central

    Pal, Aparajita; Talukdar, Dipa; Roy, Anirban; Ray, Subhankar; Mallick, Asish; Mandal, Chitra; Ray, Manju

    2015-01-01

    Purpose The normal metabolite methylglyoxal (MG) specifically kills cancer cells by inhibiting glycolysis and mitochondrial respiration without much adverse effect upon normal cells. Though the anticancer property of MG is well documented, its gradual enzymatic degradation in vivo has prompted interest in developing a nanoparticulate drug delivery system to protect it and also to enhance its efficacy. Materials and methods MG-conjugated chitosan nanoparticles (Nano-MG) were prepared by conjugating the carbonyl group of MG with the amino group of chitosan polymer (Schiff’s base formation). Nano-MG were characterized in detail using the dynamic light scattering method, zeta potential measurement, Fourier transform infrared spectroscopy, and transmission electron microscopic analysis. Amount of MG anchored to Nano-MG, stability of Nano-MG, and in vitro release of MG from Nano-MG were estimated spectrophotometrically. Ehrlich ascites carcinoma (EAC) cells, human breast cancer cell line HBL-100, and lung epithelial adenocarcinoma cell line A549 were used as test systems to compare Nano-MG with bare MG in vitro. Cytotoxicity to EAC cells was evaluated by the trypan blue dye exclusion test, and cell viability of HBL-100 and A549 cells were studied using 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis of HBL-100 cells was assessed by flow cytometry and confocal microscopy. In vivo studies were performed on both EAC cells inoculated and also in sarcoma-180-induced solid tumor-bearing Swiss albino mice to assess the anticancer activity of Nano-MG in comparison to bare MG with varying doses, times, and administrative routes. Results Fourier transform infrared spectroscopy revealed the presence of imine groups in Nano-MG due to conjugation of the amino group of chitosan and carbonyl group of MG with diameters of nanoparticles ranging from 50–100 nm. The zeta potential of Nano-MG was +21 mV and they contained approximately 100 μg of MG

  3. The Pursuit of a Scalable Nanofabrication Platform for Use in Material and Life Science Applications

    PubMed Central

    GRATTON, STEPHANIE E. A.; WILLIAMS, STUART S.; NAPIER, MARY E.; POHLHAUS, PATRICK D.; ZHOU, ZHILIAN; WILES, KENTON B.; MAYNOR, BENJAMIN W.; SHEN, CLIFTON; OLAFSEN, TOVE; SAMULSKI, EDWARD T.; DESIMONE, JOSEPH M.

    2008-01-01

    CONSPECTUS In this Account, we describe the use of perfluoropolyether (PFPE)-based materials that are able to accurately mold and replicate micro- and nanosized features using traditional techniques such as embossing as well as new techniques that we developed to exploit the exceptional surface characteristics of fluorinated substrates. Because of the unique partial wetting and nonwetting characteristics of PFPEs, we were able to go beyond the usual molding and imprint lithography approaches and have created a technique called PRINT (Particle [or Pattern] Replication In Nonwetting Templates). PRINT is a distinctive “top-down” fabrication technique capable of generating isolated particles, arrays of particles, and arrays of patterned features for a plethora of applications in both nanomedicine and materials science. A particular strength of the PRINT technology is the high-resolution molding of well-defined particles with precise control over size, shape, deformability, and surface chemistry. The level of replication obtained showcases some of the unique characteristics of PFPE molding materials. In particular, these materials arise from very low surface energy precursors with positive spreading coefficients, can be photocured at ambient temperature, and are minimally adhesive, nonswelling, and conformable. These distinctive features enable the molding of materials with unique attributes and nanometer resolution that have unprecedented scientific and technological value. For example, in nanomedicine, the use of PFPE materials with the PRINT technique allows us to design particles in which we can tailor key therapeutic parameters such as bioavailability, biodistribution, target-specific cell penetration, and controlled cargo release. Similarly, in materials science, we can fabricate optical films and lens arrays, replicate complex, naturally occurring objects such as adenovirus particles, and create 2D patterned arrays of inorganic oxides. PMID:18720952

  4. Integrated bioethanol and biomanure production from potato waste.

    PubMed

    Chintagunta, Anjani Devi; Jacob, Samuel; Banerjee, Rintu

    2016-03-01

    Disposal of potato processing waste and the problem of pollution associated with it is a vital issue that is being faced by the potato processing plants. The conventional peeling methods presently followed in the processing plants for removing the potato peel, also result in the loss of some portion of the mash which is rich in starch. Indiscriminate discharge of the waste causes detrimental effects in the environment, so this problem can be resolved by successful utilization of the waste for the generation of value added products. Hence, the present work focuses on integrated production of bioethanol and biomanure to utilize the waste completely leading to zero waste generation. The first part of the work describes a comparative study of ethanol production from potato peel and mash wastes by employing co-culture of Aspergillus niger and Saccharomyces cerevisiae at various incubation time (24-120 h) instead of application of enzymes. The solid state fermentation of potato peel and mash inoculated with co-culture, resulted in bioethanol production of 6.18% (v/v) and 9.30% (v/v) respectively. In the second part of the work, the residue obtained after ethanol production was inoculated with seven different microorganisms (Nostoc muscorum, Fischerella muscicola, Anabaena variabilis, Aulosira fertilissima, Cylindrospermum muscicola, Azospirillium lipoferum, Azotobacter chroococcum) and mixture of all the organisms in equal ratio for nitrogen (N), phosphorous (P) and potassium (K) enrichment. Among them, A. variabilis was found to enrich N, P and K content of the residue by nearly 7.66, 21.66 and 15 fold than that of the initial content, ultimately leading to improved N:P:K ratio of approximately 2:1:1. The application of simultaneous saccharification and fermentation (SSF) for the conversion of potato waste to ethanol and enrichment of residue obtained after ethanol production with microorganisms to be used as manure envisages environmental sustainability. PMID:26316099

  5. Integrating Data from Geological Investigations into Urban Watershed Restoration Efforts

    NASA Astrophysics Data System (ADS)

    Kaufman, M.; Rogers, D.; Murray, K.

    2012-04-01

    To improve urban watershed restoration efforts, a framework for integrating the outputs from subsurface geological investigations into land use planning is developed. This framework synthesizes the data generated at the individual parcel scale, including a full inventory of water flows on the surface and within the subsurface, and the synergy between contaminant properties and the geological environment. Using a case study approach, over 3000 sites of environmental contamination were investigated in the heavily urbanized Rouge River watershed of southeastern Michigan, USA. Analysis of the remediation costs at these contaminated sites and the patterns of groundwater contamination strongly suggest that land use planning in this region has not incorporated the basic sciences of geology and geomorphology. At a broad geographical scale, the siting of cities near flowing water and their industries above vulnerable geology resulted in large extents of contamination that are costly to remediate. This historical process was complicated by the unplanned nature of urban sprawl, as industrial sites were located in areas of high groundwater vulnerability, and their spatial juxtaposition created unintended consequences by expanding the pathways for contamination transport. To help remedy this situation, it is recommended that urban watershed restoration efforts include groundwater vulnerability studies, and these studies should become a basic component of the land use planning process, much as environmental site assessments are for the real estate industry. Moreover, through source control, the parcel scale is where science-based landscape planning can most effectively aid in urban watershed restoration efforts and prevent further environmental damage to land being considered for new development or redevelopment.

  6. Integrated Radial Probe Transition From MMIC to Waveguide

    NASA Technical Reports Server (NTRS)

    Samoska, Lorene; Chattopadhyay, Goutam

    2007-01-01

    A radial probe transition between a monolithic microwave integrated circuit (MMIC) and a waveguide has been designed for operation at frequency of 340 GHz and to be fabricated as part of a monolithic unit that includes the MMIC. Integrated radial probe transitions like this one are expected to be essential components of future MMIC amplifiers operating at frequencies above 200 GHz. While MMIC amplifiers for this frequency range have not yet been widely used because they have only recently been developed, there are numerous potential applications for them-- especially in scientific instruments, test equipment, radar, and millimeter-wave imaging systems for detecting hidden weapons.

  7. Microsystem integration from RF to millimeter wave applications

    NASA Astrophysics Data System (ADS)

    Vähä-Heikkilä, T.; Lahti, M.

    2015-05-01

    Radio frequency systems have been applied successfully to consumer products. Typically these radios operate up to 6 GHz. During recent years, interest towards microwave (up to 30 GHz) and millimeter wave frequencies (30 ... 300 GHz) has increased significantly. Technologies have been developed to have high performance microwave and millimeter wave components. On the other hand, integration and packaging technologies have not developed as fast while their importance is crucial especially in consumer applications. This presentation focuses to latest trends in wireless microsystem component integration and packaging trends backed up with demonstrators and measured results based on VTT's demonstrations.

  8. Do integrated care structures foster processes of integration? A quasi-experimental study in frail elderly care from the professional perspective

    PubMed Central

    Janse, Benjamin; Huijsman, Robbert; de Kuyper, Ruben Dennis Maurice; Fabbricotti, Isabelle Natalina

    2016-01-01

    Objective This study explores the processes of integration that are assumed to underlie integrated care delivery. Design A quasi-experimental design with a control group was used; a new instrument was developed to measure integration from the professional perspective. Setting and participants Professionals from primary care practices and home-care organizations delivering care to the frail elderly in the Walcheren region of the Netherlands. Intervention An integrated care intervention specifically targeting frail elderly patients was implemented. Main Outcome Measures Structural, cultural, social and strategic integration and satisfaction with integration. Results The intervention significantly improved structural, cultural and social integration, agreement on goals, interests, power and resources and satisfaction with integration. Conclusions This study confirms that integrated care structures foster processes of integration among professionals. Trial registration Current Controlled Trials ISRCTN05748494. PMID:27174858

  9. 16 CFR 312.8 - Confidentiality, security, and integrity of personal information collected from children.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Confidentiality, security, and integrity of... Confidentiality, security, and integrity of personal information collected from children. The operator must establish and maintain reasonable procedures to protect the confidentiality, security, and integrity...

  10. The Integrated Design Process from the Facilitator's Perspective

    ERIC Educational Resources Information Center

    Lee, Jeehyun

    2014-01-01

    The focus of this study was to clarify the integrated design process from an educational standpoint, and identify its influencing factors and the role of facilitator. Through a literature review, the integrated design process and the role of facilitator were framed, and through the case study, the whole process of integrated design and the…

  11. 16 CFR 312.8 - Confidentiality, security, and integrity of personal information collected from children.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Confidentiality, security, and integrity of... Confidentiality, security, and integrity of personal information collected from children. The operator must establish and maintain reasonable procedures to protect the confidentiality, security, and integrity...

  12. Micro- and Nanofabrication Techniques

    NASA Astrophysics Data System (ADS)

    Fermon, C.

    This chapter is intended to give readers a brief overview of the numerous techniques involved in the fabrication of small magnetic devices. Until recently there has been a wide distinction between semi-conductor engineering and metallic and magnetic devices fabrication, the main reason being due to the huge investments in terms of money and manpower devoted to semiconductors rather than real technical limitations. With the advent of spin electronics, the number of metal and magnetic devices are increasing and in some instances, semiconductor and magnetic device fabrication have started to merge and are currently the topic of intensive research in some areas (e.g. in MRAMs). In the future it is anticipated, that metal and magnetic devices will be further employed at an accelerated pace in the electronics and computing sectors due to their inherent advantages, e.g. smaller, faster, more powerful non-volatile memories.

  13. Integrating Wind and Solar Energy in the U.S. Bulk Power System: Lessons from Regional Integration Studies

    SciTech Connect

    Bird, L.; Lew, D.

    2012-09-01

    Two recent studies sponsored by the U.S. Department of Energy (DOE) and the National Renewable Energy Laboratory (NREL) have examined the impacts of integrating high penetrations of wind and solar energy on the Eastern and Western electric grids. The Eastern Wind Integration and Transmission Study (EWITS), initiated in 2007, examined the impact on power system operations of reaching 20% to 30% wind energy penetration in the Eastern Interconnection. The Western Wind and Solar Integration Study (WWSIS) examined the operational implications of adding up to 35% wind and solar energy penetration to the Western Interconnect. Both studies examined the costs of integrating variable renewable energy generation into the grid and transmission and operational changes that might be necessary to address higher penetrations of wind or solar generation. This paper identifies key insights from these regional studies for integrating high penetrations of renewables in the U.S. electric grid. The studies share a number of key findings, although in some instances the results vary due to differences in grid operations and markets, the geographic location of the renewables, and the need for transmission.

  14. Evaluation of the Integrated Services Pilot Program from Western Australia

    ERIC Educational Resources Information Center

    Hancock, Peter; Cooper, Trudi; Bahn, Susanne

    2009-01-01

    Independent evaluation of refugee-focused programs in developed nations is increasingly a mandatory requirement of funding bodies and government agencies. This paper presents an evaluation of the Integrated Services Centre (ISC) Pilot Project that was conducted in Australia in 2007 and early 2008. The purpose of the ISC program was to provide…

  15. The Value of ERP Curriculum Integration: Perspectives from the Research

    ERIC Educational Resources Information Center

    Hepner, Michelle; Dickson, Warren

    2013-01-01

    In the current economic conditions, many institutions face dwindling budgets and an increased focus on proving the value of the education provided. The effort and costs required to integrate Enterprise Resource Planning systems into course curricula are a significant investment of resources for any university. This paper examines the expense of…

  16. Lessons from Large-Scale Renewable Energy Integration Studies: Preprint

    SciTech Connect

    Bird, L.; Milligan, M.

    2012-06-01

    In general, large-scale integration studies in Europe and the United States find that high penetrations of renewable generation are technically feasible with operational changes and increased access to transmission. This paper describes other key findings such as the need for fast markets, large balancing areas, system flexibility, and the use of advanced forecasting.

  17. Report from the First Snake Genomics and Integrative Biology Meeting

    PubMed Central

    Castoe, Todd A.; Braun, Edward L.; Bronikowski, Anne M.; Cox, Christian L.; Rabosky, Alison R. Davis; Jason de Koning, A.P.; Dobry, Jason; Fujita, Matthew K.; Giorgianni, Matt W; Hargreaves, Adam; Henkel, Christiaan V.; Mackessy, Stephen P.; O’Meally, Denis; Rokyta, Darin R.; Secor, Stephen M.; Streicher, Jeffrey W.; Wray, Kenneth P.; Yokoyama, Ken D.; Pollock, David D.

    2012-01-01

    This report summarizes the proceedings of the 1st Snake Genomics and Integrative Biology Meeting held in Vail, CO USA, 5-8 October 2011. The meeting had over twenty registered participants, and was conducted as a single session of presentations. Goals of the meeting included coordination of genomic data collection and fostering collaborative interactions among researchers using snakes as model systems. PMID:23451292

  18. Powering up Technology from Passive Access to Active Integration

    ERIC Educational Resources Information Center

    Taylor, Shay

    2015-01-01

    For many educators, working with students who were deaf or hard of hearing was the need to have "access." Access to technology was the tool of choice for providing integration that has come to be so much more than gadgets. It is intercurricular--math software incorporates reading, science websites support language skills. It is…

  19. Organic printed photonics: From microring lasers to integrated circuits.

    PubMed

    Zhang, Chuang; Zou, Chang-Ling; Zhao, Yan; Dong, Chun-Hua; Wei, Cong; Wang, Hanlin; Liu, Yunqi; Guo, Guang-Can; Yao, Jiannian; Zhao, Yong Sheng

    2015-09-01

    A photonic integrated circuit (PIC) is the optical analogy of an electronic loop in which photons are signal carriers with high transport speed and parallel processing capability. Besides the most frequently demonstrated silicon-based circuits, PICs require a variety of materials for light generation, processing, modulation, and detection. With their diversity and flexibility, organic molecular materials provide an alternative platform for photonics; however, the versatile fabrication of organic integrated circuits with the desired photonic performance remains a big challenge. The rapid development of flexible electronics has shown that a solution printing technique has considerable potential for the large-scale fabrication and integration of microsized/nanosized devices. We propose the idea of soft photonics and demonstrate the function-directed fabrication of high-quality organic photonic devices and circuits. We prepared size-tunable and reproducible polymer microring resonators on a wafer-scale transparent and flexible chip using a solution printing technique. The printed optical resonator showed a quality (Q) factor higher than 4 × 10(5), which is comparable to that of silicon-based resonators. The high material compatibility of this printed photonic chip enabled us to realize low-threshold microlasers by doping organic functional molecules into a typical photonic device. On an identical chip, this construction strategy allowed us to design a complex assembly of one-dimensional waveguide and resonator components for light signal filtering and optical storage toward the large-scale on-chip integration of microscopic photonic units. Thus, we have developed a scheme for soft photonic integration that may motivate further studies on organic photonic materials and devices. PMID:26601256

  20. Organic printed photonics: From microring lasers to integrated circuits

    PubMed Central

    Zhang, Chuang; Zou, Chang-Ling; Zhao, Yan; Dong, Chun-Hua; Wei, Cong; Wang, Hanlin; Liu, Yunqi; Guo, Guang-Can; Yao, Jiannian; Zhao, Yong Sheng

    2015-01-01

    A photonic integrated circuit (PIC) is the optical analogy of an electronic loop in which photons are signal carriers with high transport speed and parallel processing capability. Besides the most frequently demonstrated silicon-based circuits, PICs require a variety of materials for light generation, processing, modulation, and detection. With their diversity and flexibility, organic molecular materials provide an alternative platform for photonics; however, the versatile fabrication of organic integrated circuits with the desired photonic performance remains a big challenge. The rapid development of flexible electronics has shown that a solution printing technique has considerable potential for the large-scale fabrication and integration of microsized/nanosized devices. We propose the idea of soft photonics and demonstrate the function-directed fabrication of high-quality organic photonic devices and circuits. We prepared size-tunable and reproducible polymer microring resonators on a wafer-scale transparent and flexible chip using a solution printing technique. The printed optical resonator showed a quality (Q) factor higher than 4 × 105, which is comparable to that of silicon-based resonators. The high material compatibility of this printed photonic chip enabled us to realize low-threshold microlasers by doping organic functional molecules into a typical photonic device. On an identical chip, this construction strategy allowed us to design a complex assembly of one-dimensional waveguide and resonator components for light signal filtering and optical storage toward the large-scale on-chip integration of microscopic photonic units. Thus, we have developed a scheme for soft photonic integration that may motivate further studies on organic photonic materials and devices. PMID:26601256

  1. An integrated workflow for characterizing intact phosphoproteins from complex mixtures

    SciTech Connect

    Wu, Si; Yang, Feng; Zhao, Rui; Tolic, Nikola; Robinson, Errol W.; Camp, David G.; Smith, Richard D.; Pasa-Tolic, Ljiljana

    2009-05-08

    The phosphorylation of any site on a given protein can affect its activity, degradation rate, ability to dock with other proteins or bind divalent cations, and/or its localization. These effects can operate within the same protein; in fact, multisite phosphorylation is a key mechanism for achieving signal integration in cells. Hence, knowing the overall phosphorylation signature of a protein is essential for understanding the "state" of a cell. However, current technologies to monitor the phosphorylation status of proteins are inefficient at determining the relative stoichiometries of phosphorylation at multiple sites. Here we report a new capability for comprehensive liquid chromatography-mass spectrometry (LC-MS) analysis of intact phosphoproteins. The technology platform built upon integrated bottom-up and top-down approach that is facilitated by intact protein reversed-phase (RP)LC concurrently coupled with Fourier transform ion cyclotron resonance (FTICR) MS and fraction collection.

  2. Flux tube spectra from approximate integrability at low energies

    SciTech Connect

    Dubovsky, S. Flauger, R.; Gorbenko, V.

    2015-03-15

    We provide a detailed introduction to a method we recently proposed for calculating the spectrum of excitations of effective strings such as QCD flux tubes. The method relies on the approximate integrability of the low-energy effective theory describing the flux tube excitations and is based on the thermodynamic Bethe ansatz. The approximate integrability is a consequence of the Lorentz symmetry of QCD. For excited states, the convergence of the thermodynamic Bethe ansatz technique is significantly better than that of the traditional perturbative approach. We apply the new technique to the lattice spectra for fundamental flux tubes in gluodynamics in D = 3 + 1 and D = 2 + 1, and to k-strings in gluodynamics in D = 2 + 1. We identify a massive pseudoscalar resonance on the worldsheet of the confining strings in SU(3) gluodynamics in D = 3 + 1, and massive scalar resonances on the worldsheet of k = 2.3 strings in SU(6) gluodynamics in D = 2 + 1.

  3. Calculating integral dose using data exported from a commercial record and verify system.

    PubMed

    Fox, C; Hardcastle, N; Lim, A; Khor, R

    2015-06-01

    Integral dose has been useful in investigations into the incidence of second primary malignancies in radiotherapy patients. This note outlines an approach to calculation of integral dose for a group of prostate patients using only data exported from a commercial record and verify system. Even though it was necessary to make some assumptions about patient anatomy, comparison with integral dose calculated from data exported from the planning system showed good agreement. PMID:25869674

  4. From Neurodegeneration to Brain Health: An Integrated Approach.

    PubMed

    Petersen, Robert B; Lissemore, Frances M; Appleby, Brian; Aggarwal, Neelum; Boyatzis, Richard; Casadesus, Gemma; Cummings, Jeff; Jack, Anthony; Perry, George; Safar, Jiri; Sajatovic, Martha; Surewicz, Witold K; Wang, Yanming; Whitehouse, Peter; Lerner, Alan

    2015-01-01

    The term "brain health" integrates general health and well-being with cognitive fitness, in the context of an environment that includes the spectrum of positive and negative factors affecting the individual. Brain health incorporates the effects of neurodegeneration in an ecological sense and the effects of environment and health practices on brain function. It also provides a framework for understanding and maximizing cognitive function across the lifespan. Despite decades of research into the pathogenesis of neurodegenerative disorders, our understanding of how to treat them is relatively rudimentary. Unidimensional approaches, such as medication monotherapies, have generally produced negative results in treatment trials. New integrative paradigms that cut across the molecular and cellular level to the individual and societal level may provide new approaches to understand and treat these disorders. This report on proceedings of a multi-disciplinary conference held in Cleveland, Ohio, in October 2013 summarizes research progress in understanding neurodegenerative disorders in a brain health context. A new "brain health" paradigm is essential to finally understand neurodegenerative disorders such as Alzheimer's disease and overcome the relative stand-still in therapeutics research that has characterized the last decade. The authors summarize progress in these emerging areas with the aim of producing new integrated scientific models for understanding brain health, potentially modifying disease course and advancing care for individuals and families affected by neurodegenerative conditions. PMID:25720413

  5. Cell adhesion strength from cortical tension - an integration of concepts.

    PubMed

    Winklbauer, Rudolf

    2015-10-15

    Morphogenetic mechanisms such as cell movement or tissue separation depend on cell attachment and detachment processes, which involve adhesion receptors as well as the cortical cytoskeleton. The interplay between the two components is of stunning complexity. Most strikingly, the binding energy of adhesion molecules is usually too small for substantial cell-cell attachment, pointing to a main deficit in our present understanding of adhesion. In this Opinion article, I integrate recent findings and conceptual advances in the field into a coherent framework for cell adhesion. I argue that active cortical tension is best viewed as an integral part of adhesion, and propose on this basis a non-arbitrary measure of adhesion strength - the tissue surface tension of cell aggregates. This concept of adhesion integrates heterogeneous molecular inputs into a single mechanical property and simplifies the analysis of attachment-detachment processes. It draws attention to the enormous variation of adhesion strengths among tissues, whose origin and function is little understood. PMID:26471994

  6. Code System to Calculate Integral Parameters with Reaction Rates from WIMS Output.

    Energy Science and Technology Software Center (ESTSC)

    1994-10-25

    Version 00 REACTION calculates different integral parameters related to neutron reactions on reactor lattices, from reaction rates calculated with WIMSD4 code, and comparisons with experimental values.

  7. A novel Streptomyces spp. integration vector derived from the S. venezuelae phage, SV1

    PubMed Central

    2014-01-01

    Background Integrating vectors based on the int/attP loci of temperate phages are convenient and used widely, particularly for cloning genes in Streptomyces spp. Results We have constructed and tested a novel integrating vector based on g27, encoding integrase, and attP site from the phage, SV1. This plasmid, pBF3 integrates efficiently in S. coelicolor and S. lividans but surprisingly fails to generate stable integrants in S. venezuelae, the natural host for phage SV1. Conclusion pBF3 promises to be a useful addition to the range of integrating vectors currently available for Streptomyces molecular genetics. PMID:24885867

  8. Leading Integrated Health and Social Care Systems: Perspectives from Research and Practice.

    PubMed

    Evans, Jenna M; Daub, Stacey; Goldhar, Jodeme; Wojtak, Anne; Purbhoo, Dipti

    2016-01-01

    As the research evidence on integrated care has evolved over the past two decades, so too has the critical role leaders have for the implementation, effectiveness and sustainability of integrated care. This paper explores what it means to be an effective leader of integrated care initiatives by drawing from the experiences of a leadership team in implementing an award-winning integrated care program in Toronto, Canada. Lessons learned are described and assessed against existing theory and research to identify which skills and behaviours facilitate effective leadership of integrated care initiatives. PMID:27009705

  9. Construction of classical superintegrable systems with higher order integrals of motion from ladder operators

    SciTech Connect

    Marquette, Ian

    2010-07-15

    We construct integrals of motion for multidimensional classical systems from ladder operators of one-dimensional systems. This method can be used to obtain new systems with higher order integrals. We show how these integrals generate a polynomial Poisson algebra. We consider a one-dimensional system with third order ladder operators and found a family of superintegrable systems with higher order integrals of motion. We obtain also the polynomial algebra generated by these integrals. We calculate numerically the trajectories and show that all bounded trajectories are closed.

  10. Obtaining a protein concentrate from integral defatted sunflower flour.

    PubMed

    Ordóñez, C; Asenjo, M G; Benitez, C; González, J L

    2001-06-01

    Proteins which are found in integral defatted sunflower flour (27% of protein in dry weight) allow us to produce a protein concentrate by means of extraction of proteins with a basic pH solution, followed by their precipitation with an acid pH solution. Once the suitable conditions for pH and temperature were fixed in order to carry out these processes, a solid proteic concentrate (71% of protein in dry weight) was obtained which was rich in glutamic and aspartic acids, with a liquid supernatant very rich in phosphorus and potassium, which might be used as an agricultural fertilizer. PMID:11333039

  11. The integrated compound parabolic concentrator: From development to demonstration

    SciTech Connect

    Winston, R.; O`Gallagher, J.J.; Duff, W.S.; Cavallaro, A.

    1997-12-31

    The authors describe the fabrication, testing and application of the Integrated Compound Parabolic Concentrator (ICPC) to solar cooling. The cooling technology is a double effect absorption cycle chiller operating at 165 C. The design parameters are optimized for this temperature range. The optical and mechanical design of the solar collector is chosen for compatibility with mass production. A project to employ approximately 350 of these collector tubes to drive a 20 ton commercial double effect chiller on an office building in Sacramento, CA has started. The authors expect the system to be operational this year.

  12. Quantum corrections from a path integral over reparametrizations

    SciTech Connect

    Makeenko, Yuri; Olesen, Poul

    2010-08-15

    We study the path integral over reparametrizations that has been proposed as an ansatz for the Wilson loops in the large-N QCD and reproduces the area law in the classical limit of large loops. We show that a semiclassical expansion for a rectangular loop captures the Luescher term associated with d=26 dimensions and propose a modification of the ansatz that reproduces the Luescher term in other dimensions, which is observed in lattice QCD. We repeat the calculation for an outstretched ellipse advocating the emergence of an analog of the Luescher term and verify this result by a direct computation of the determinant of the Laplace operator and the conformal anomaly.

  13. Integrable cosmological models from higher dimensional Einstein equations

    SciTech Connect

    Sano, Masakazu; Suzuki, Hisao

    2007-09-15

    We consider the cosmological models for the higher dimensional space-time which includes the curvatures of our space as well as the curvatures of the internal space. We find that the condition for the integrability of the cosmological equations is that the total space-time dimensions are D=10 or D=11 which is exactly the conditions for superstrings or M theory. We obtain analytic solutions with generic initial conditions in the four-dimensional Einstein frame and study the accelerating universe when both our space and the internal space have negative curvatures.

  14. From Behavior to Neural Dynamics: An Integrated Theory of Attention.

    PubMed

    Buschman, Timothy J; Kastner, Sabine

    2015-10-01

    The brain has a limited capacity and therefore needs mechanisms to selectively enhance the information most relevant to one's current behavior. We refer to these mechanisms as "attention." Attention acts by increasing the strength of selected neural representations and preferentially routing them through the brain's large-scale network. This is a critical component of cognition and therefore has been a central topic in cognitive neuroscience. Here we review a diverse literature that has studied attention at the level of behavior, networks, circuits, and neurons. We then integrate these disparate results into a unified theory of attention. PMID:26447577

  15. Watching chips work: picosecond hot electron light emission from integrated circuits

    NASA Astrophysics Data System (ADS)

    Kash, J. A.; Tsang, J. C.

    2000-03-01

    The picosecond pulses of hot carrier luminescence that are observed from individual submicron FETs in CMOS circuits can be used to describe the internal operation of integrated circuits. To effectively use the weak emission pulses, we have developed a method called picosecond integrated circuit analysis (PICA) which simultaneously images and time resolves the emission. PICA has been used to characterize the operation of integrated circuits from simple ring oscillators to a full microprocessors. Examples of circuit characterization and fault diagnosis are presented.

  16. Nanopipette combined with quartz tuning fork-atomic force microscope for force spectroscopy/microscopy and liquid delivery-based nanofabrication

    SciTech Connect

    An, Sangmin; Lee, Kunyoung; Kim, Bongsu; Noh, Haneol; Kim, Jongwoo; Kwon, Soyoung; Lee, Manhee; Hong, Mun-Heon; Jhe, Wonho

    2014-03-15

    This paper introduces a nanopipette combined with a quartz tuning fork-atomic force microscope system (nanopipette/QTF-AFM), and describes experimental and theoretical investigations of the nanoscale materials used. The system offers several advantages over conventional cantilever-based AFM and QTF-AFM systems, including simple control of the quality factor based on the contact position of the QTF, easy variation of the effective tip diameter, electrical detection, on-demand delivery and patterning of various solutions, and in situ surface characterization after patterning. This tool enables nanoscale liquid delivery and nanofabrication processes without damaging the apex of the tip in various environments, and also offers force spectroscopy and microscopy capabilities.

  17. Experimental Data from the Proteomics Research Center for Integrative Biology

    DOE Data Explorer

    Smith, Richard D.

    The possible roles and importance of proteomics are rapidly growing across essentially all areas of biological research. The precise and comprehensive measurement of levels of expressed proteins and their modified forms can provide new insights into the molecular nature of cell-signaling pathways and networks, the cell cycle, cellular differentiation, and other processes relevant to understanding human health and the progression of various disease states. The ability to characterize protein complexes complements this capability, allowing hypotheses to be tested and the biological system operation to be defined. The Proteomics Research Center for Integrative Biology is a national user facility established and funded by the National Institute of General Medical Sciences component of the National Institutes of Health. This Center has been established to serve the biomedical research community by developing and integrating new proteomic technologies for collaborative and service studies, disseminating the new technologies, and training scientists in their use. The Center is housed in DOE’s William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) at the Pacific Northwest National Laboratory.

  18. Nutritional phenotype databases and integrated nutrition: from molecules to populations.

    PubMed

    Gibney, Michael J; McNulty, Breige A; Ryan, Miriam F; Walsh, Marianne C

    2014-05-01

    In recent years, there has been a great expansion in the nature of new technologies for the study of all biologic subjects at the molecular and genomic level and these have been applied to the field of human nutrition. The latter has traditionally relied on a mix of epidemiologic studies to generate hypotheses, dietary intervention studies to test these hypotheses, and a variety of experimental approaches to understand the underlying explanatory mechanisms. Both the novel and traditional approaches have begun to carve out separate identities vís-a-vís their own journals, their own international societies, and their own national and international symposia. The present review draws on the advent of large national nutritional phenotype databases and related technological developments to argue the case that there needs to be far more integration of molecular and public health nutrition. This is required to address new joint approaches to such areas as the measurement of food intake, biomarker discovery, and the genetic determinants of nutrient-sensitive genotypes and other areas such as personalized nutrition and the use of new technologies with mass application, such as in dried blood spots to replace venipuncture or portable electronic devices to monitor food intake and phenotype. Future development requires the full integration of these 2 disciplines, which will provide a challenge to both funding agencies and to university training of nutritionists. PMID:24829488

  19. Progress in governance of converging technologies integrated from the nanoscale.

    PubMed

    Roco, Mihail C

    2006-12-01

    It is expected that convergence of nanotechnology, modern biology, the digital revolution, and cognitive sciences will bring about tremendous improvements in transformative tools, generate new products and services, enable human personal abilities and social achievements, and in time reshape societal relationships. This article focuses on the progress made in governance of such converging, emerging technologies that are integrated with more traditional technologies. The proposed framework for governance calls for several key functions: supporting the transformative impact; advancing responsible development that includes health, safety, and ethical concerns; encouraging national and global partnerships; and commitment to long-term planning with effects on human development. Principles of good governance include participation of all those involved or affected by the new technologies, transparency, participant responsibility, and effective strategic planning. Introduction and management of converging technologies must be done with respect for immediate concerns (such as information technology privacy, access to medical advancements, and addressing toxicity of new nanomaterials) and longer-term concerns (such as human development and concern for human integrity, dignity, and welfare). Four levels of governance of converging technologies have been identified: (a) adapting existing regulations and organizations; (b) establishing new programs, regulations, and organizations specifically to handle converging technologies; (c) national policies and institutional capacity building; and (d) international agreements and partnerships. PMID:17312249

  20. An integrating sphere to measure CD from difficult samples

    PubMed

    Castiglioni; Albertini

    2000-05-01

    Integrating spheres are widely used with UV-Vis and occasionally with infrared spectrophotometers to measure different types of samples, either in transmission mode (scattered transmission accessories) or in total/diffuse reflectance mode. We built a prototype sphere of the demountable type, which fits easily the sample compartment of a commercial CD spectropolarimeter, requiring neither any alignment nor the use of a dedicated photomultiplier. Samples can be inserted either at the sphere entrance (for scattered transmission mode) or in the center of the sphere (for total reflectance experiments). Selected experimental data are presented to evaluate sphere efficiency, its wavelength range and results with a single sample in different forms. Copyright 2000 Wiley-Liss, Inc. PMID:10790200

  1. An Integrated Linkage Map for Cultivated Peanut Derived from Two RILs Populations

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A comparable integrated map for cultivated peanut (Arachis hypogaea L.) was constructed from the integration of two recombinant inbred line (RIL) populations in which two runner type cultivars, one Spanish type cultivar and one breeding line derived from a cross of Virginia type and hirsuta type wer...

  2. Integrated management of childhood illness: challenges from the community.

    PubMed

    Pelto, G H

    1994-07-01

    Following an integrated approach to the management of childhood illnesses provides an opportunity to increase the effectiveness of the delivery of primary health care services through the efficient use of case management interventions. However, the potential impact of this approach to morbidity and mortality depends ultimately upon its use, and various constraints to use exist. There are constraints that are characteristics of the services themselves (such as long waiting lines); there are constrains within households (ideational, psychological, and socioeconomic); and there are constraints within communities (systems of transportation as well as geographic and social barriers). Unfortunately, inadequate theory exists to facilitate efforts to overcome the constraints which require behavioral and social change. This is due, in part, to the low priority placed by societies on the development of applied social science, as contrasted with biomedical science. Whereas the main factors that affect the utilization of health resources are well known, the relative importance of these factors in different conditions and situations (and their mechanisms of interaction) are not understood. Therefore, strategies which work in one context fail in another. This situation will continue until efforts are made to develop more systematic approaches to these experiences. However, the main challenge is to apply existing research tools and techniques and develop new ones which will permit the measurement and analysis of social and behavioral variables in a way that contributes to our understanding of them. The successful institutionalization of integrated management of childhood illness will also require the adaptation of generic guidelines to local communities. This process depends upon information on community beliefs and practices as well as on ways to use such information. Current techniques, such as rapid assessment procedures and focused ethnographic studies, must be further

  3. Sites of Retroviral DNA Integration: From Basic Research to Clinical Applications

    PubMed Central

    Serrao, Erik; Engelman, Alan N.

    2016-01-01

    One of the most crucial steps in the life cycle of a retrovirus is the integration of the viral DNA (vDNA) copy of the RNA genome into the genome of an infected host cell. Integration provides for efficient viral gene expression as well as for the segregation of the viral genomes to daughter cells upon cell division. Some integrated viruses are not well expressed, and cells latently infected with HIV-1 can resist the action of potent antiretroviral drugs and remain dormant for decades. Intensive research has been dedicated to understanding the catalytic mechanism of integration, as well as the viral and cellular determinants that influence integration site distribution throughout the host genome. In this review we summarize the evolution of techniques that have been used to recover and map retroviral integration sites, from the early days that first indicated that integration could occur in multiple cellular DNA locations, to current technologies that map upwards of millions of unique integration sites from single in vitro integration reactions or cell culture infections. We further review important insights gained from the use of such mapping techniques, including the monitoring of cell clonal expansion in patients treated with retrovirus-based gene therapy vectors, or AIDS patients on suppressive antiretroviral therapy (ART). These insights span from integrase (IN) enzyme sequence preferences within target DNA (tDNA) at the sites of integration, to the roles of host cellular proteins in mediating global integration distribution, to the potential relationship between genomic location of vDNA integration site and retroviral latency. PMID:26508664

  4. Sites of retroviral DNA integration: From basic research to clinical applications.

    PubMed

    Serrao, Erik; Engelman, Alan N

    2016-01-01

    One of the most crucial steps in the life cycle of a retrovirus is the integration of the viral DNA (vDNA) copy of the RNA genome into the genome of an infected host cell. Integration provides for efficient viral gene expression as well as for the segregation of viral genomes to daughter cells upon cell division. Some integrated viruses are not well expressed, and cells latently infected with human immunodeficiency virus type 1 (HIV-1) can resist the action of potent antiretroviral drugs and remain dormant for decades. Intensive research has been dedicated to understanding the catalytic mechanism of integration, as well as the viral and cellular determinants that influence integration site distribution throughout the host genome. In this review, we summarize the evolution of techniques that have been used to recover and map retroviral integration sites, from the early days that first indicated that integration could occur in multiple cellular DNA locations, to current technologies that map upwards of millions of unique integration sites from single in vitro integration reactions or cell culture infections. We further review important insights gained from the use of such mapping techniques, including the monitoring of cell clonal expansion in patients treated with retrovirus-based gene therapy vectors, or patients with acquired immune deficiency syndrome (AIDS) on suppressive antiretroviral therapy (ART). These insights span from integrase (IN) enzyme sequence preferences within target DNA (tDNA) at the sites of integration, to the roles of host cellular proteins in mediating global integration distribution, to the potential relationship between genomic location of vDNA integration site and retroviral latency. PMID:26508664

  5. Integrated circuit for processing a low-frequency signal from a seismic detector

    SciTech Connect

    Malashevich, N. I.; Roslyakov, A. S.; Polomoshnov, S. A. Fedorov, R. A.

    2011-12-15

    Specific features for the detection and processing of a low-frequency signal from a seismic detector are considered in terms of an integrated circuit based on a large matrix crystal of the 5507 series. This integrated circuit is designed for the detection of human movements. The specific features of the information signal, obtained at the output of the seismic detector, and the main characteristics of the integrated circuit and its structure are reported.

  6. Converged Nuclear Quantum Statistics from Semi-Classical Path Integrals

    NASA Astrophysics Data System (ADS)

    Poltavskyi, Igor; Tkatchenko, Alexandre

    2015-03-01

    The quantum nature of nuclear motions plays a vital role in the structure, stability, and thermodynamics of molecular systems. The standard approach to take nuclear quantum effects (NQE) into account is the Feynman-Kac imaginary-time path-integral molecular dynamics (PIMD). Conventional PIMD simulations require exceedingly large number of classical subsystems (beads) to accurately capture NQE, resulting in considerable computational cost even at room temperature due to the rather high internal vibrational frequencies of many molecules of interest. We propose a novel parameter-free form for the PI partition function and estimators to calculate converged thermodynamic averages. Our approach requires the same ingredients as the conventional PIMD simulations, but decreases the number of required beads by roughly an order of magnitude. This greatly extends the applicability of ab initio PIMD for realistic molecular systems. The developed method has been applied to study the thermodynamics of N2, H2O, CO2, and C6H6 molecules. For all of the considered systems at room temperature, 4 to 8 beads are enough to recover the NQE contribution to the total energy within 2% of the fully converged quantum result.

  7. Integration of nanoimprint lithography with block copolymer directed self-assembly for fabrication of a sub-20 nm template for bit-patterned media.

    PubMed

    Yang, XiaoMin; Xiao, Shuaigang; Hu, Wei; Hwu, Justin; van de Veerdonk, René; Wago, Koichi; Lee, Kim; Kuo, David

    2014-10-01

    We propose a novel strategy to integrate the nanoimprint lithography (NIL) technique with directed self-assembly (DSA) of block copolymer (BCP) for providing a robust, high-yield, and low-defect-density path to sub-20 nm dense patterning. Through this new NIL-DSA method, UV nanoimprint resist is used as the DSA copolymer pre-pattern to expedite the DSA process. This method was successfully used to fabricate a 1.0 Td in(-2) servo-integrated nanoimprint template for bit-patterned media (BPM) application. The fabricated template was used for UV-cure NIL on a 2.5-inch disk. The imprint resist patterns were further transferred into the underlying CoCrPt magnetic layer through a carbon hard mask using ion beam etching. The successful integration of the NIL technique with the DSA process provides us with a new route to BPM nanofabrication, which includes the following three major advantages: (1) a simpler and faster way to implement DSA for high-density BPM patterning; (2) a novel method for fabricating a high-quality dot pattern template through an iterative imprint-DSA-template procedure; and (3) an uncomplicated integration scheme for implementing non-periodic servo features with BCP patterns, thus accelerating the transition of moving the DSA technique from laboratory research to the BPM manufacturing environment. PMID:25189432

  8. Uranium removal from soils: An overview from the Uranium in Soils Integrated Demonstration program

    SciTech Connect

    Francis, C.W.; Brainard, J.R.; York, D.A.; Chaiko, D.J.; Matthern, G.

    1994-09-01

    An integrated approach to remove uranium from uranium-contaminated soils is being conducted by four of the US Department of Energy national laboratories. In this approach, managed through the Uranium in Soils Integrated Demonstration program at the Fernald Environmental Management Project, Fernald, Ohio, these laboratories are developing processes that selectively remove uranium from soil without seriously degrading the soil`s physicochemical characteristics or generating waste that is difficult to manage or dispose of. These processes include traditional uranium extractions that use carbonate as well as some nontraditional extraction techniques that use citric acid and complex organic chelating agents such as naturally occurring microbial siderophores. A bench-scale engineering design for heap leaching; a process that uses carbonate leaching media shows that >90% of the uranium can be removed from the Fernald soils. Other work involves amending soils with cultures of sulfur and ferrous oxidizing microbes or cultures of fungi whose role is to generate mycorrhiza that excrete strong complexers for uranium. Aqueous biphasic extraction, a physical separation technology, is also being evaluated because of its ability to segregate fine particulate, a fundamental requirement for soils containing high levels of silt and clay. Interactions among participating scientists have produced some significant progress not only in evaluating the feasibility of uranium removal but also in understanding some important technical aspects of the task.

  9. Rotating parallel ray omni-directional integration for instantaneous pressure reconstruction from measured pressure gradient

    NASA Astrophysics Data System (ADS)

    Liu, Xiaofeng; Siddle-Mitchell, Seth

    2015-11-01

    This paper presents a novel pressure reconstruction method featuring rotating parallel ray omni-directional integration, as an improvement over the circular virtual boundary integration method introduced by Liu and Katz (2003, 2006, 2008 and 2013) for non-intrusive instantaneous pressure measurement in incompressible flow field. Unlike the virtual boundary omni-directional integration, where the integration path is originated from a virtual circular boundary at a finite distance from the real boundary of the integration domain, the new method utilizes parallel rays, which can be viewed as being originated from a distance of infinity, as guidance for integration paths. By rotating the parallel rays, omni-directional paths with equal weights coming from all directions toward the point of interest at any location within the computation domain will be generated. In this way, the location dependence of the integration weight inherent in the old algorithm will be eliminated. By implementing this new algorithm, the accuracy of the reconstructed pressure for a synthetic rotational flow in terms of r.m.s. error from theoretical values is reduced from 1.03% to 0.30%. Improvement is further demonstrated from the comparison of the reconstructed pressure with that from the Johns Hopkins University isotropic turbulence database (JHTDB). This project is funded by the San Diego State University.

  10. Integrative vs. Traditional Learning from the Student Perspective

    PubMed Central

    Kadmon, Guni; Schmidt, Jan; De Cono, Nicola; Kadmon, Martina

    2011-01-01

    Background: The interdisciplinary surgery block of the reformed undergraduate curriculum HeiCuMed includes daily cycles of interactive case-based seminars, problem-based tutorials, case presentation by students, skills and communication training, and bedside teaching. The teaching doctors receive didactic training. In contrast, the previous traditional course was based on lectures with only two weekly hours of bedside teaching. Didactic training was not available. Objective: The present work aims at analysing the importance of active participation of students and the didactic components of the reformed and traditional curricula, which contribute to successful learning as evaluated by the students. Method: Differentiated student evaluations of the undergraduate surgical courses between 1999 and 2008 were examined by correlation and regression analyses. Results: The evaluation scores for organisation, dedication of the teaching staff, their ability to make lessons interesting and complex topics easily understandable, and the subjective gain of knowledge were significantly better in HeiCuMed than in the traditional curriculum. However, the dependence of knowledge gain on the didactic quality was the same in both curricula. The quality of discussions and the ability of the teaching doctors to promote active student participation were important to the subjective gain of knowledge in both seminars and practical courses of the reformed curriculum as well as for the overall evaluation of the practical courses but not the gain of knowledge in the traditional curriculum. Conclusion: The findings confirm psychological-educational perceptions, that competent implementation of integrative didactical methods is more important to successful teaching and the subjective gain of knowledge than knowledge transfer by traditional classroom teaching. PMID:21818238

  11. Integrated healthy workplace model: An experience from North Indian industry

    PubMed Central

    Thakur, Jarnail Singh; Bains, Puneet; Kar, Sitanshu Sekhar; Wadhwa, Sanjay; Moirangthem, Prabha; Kumar, Rajesh; Wadwalker, Sanjay; Sharma, Yashpal

    2012-01-01

    Background: Keeping in view of rapid industrialization and growing Indian economy, there has been a substantial increase in the workforce in India. Currently there is no organized workplace model for promoting health of industrial workers in India. Objective: To develop and implement a healthy workplace model in three industrial settings of North India. Materials and Methods: An operations research was conducted for 12 months in purposively selected three industries of Chandigarh. In phase I, a multi-stakeholder workshop was conducted to finalize the components and tools for the healthy workplace model. NCD risk factors were assessed in 947 employees in these three industries. In phase II, the healthy workplace model was implemented on pilot basis for a period of 12 months in these three industries to finalize the model. Findings: Healthy workplace committee with involvement of representatives of management, labor union and research organization was formed in three industries. Various tools like comprehensive and rapid healthy workplace assessment forms, NCD work-lite format for risk factors surveillance and monitoring and evaluation format were developed. The prevalence of tobacco use, ever alcoholics was found to be 17.8% and 47%, respectively. Around one-third (28%) of employees complained of back pain in the past 12 months. Healthy workplace model with focus on three key components (physical environment, psychosocial work environment, and promoting healthy habits) was developed, implemented on pilot basis, and finalized based on experience in participating industries. A stepwise approach for model with a core, expanded, and optional components were also suggested. An accreditation system is also required for promoting healthy workplace program. Conclusion: Integrated healthy workplace model is feasible, could be implemented in industrial setting in northern India and needs to be pilot tested in other parts of the country. PMID:23776318

  12. Integrated INS/GPS Navigation from a Popular Perspective

    NASA Technical Reports Server (NTRS)

    Omerbashich, Mensur

    2002-01-01

    Inertial navigation, blended with other navigation aids, Global Positioning System (GPS) in particular, has gained significance due to enhanced navigation and inertial reference performance and dissimilarity for fault tolerance and anti-jamming. Relatively new concepts based upon using Differential GPS (DGPS) blended with Inertial (and visual) Navigation Sensors (INS) offer the possibility of low cost, autonomous aircraft landing. The FAA has decided to implement the system in a sophisticated form as a new standard navigation tool during this decade. There have been a number of new inertial sensor concepts in the recent past that emphasize increased accuracy of INS/GPS versus INS and reliability of navigation, as well as lower size and weight, and higher power, fault tolerance, and long life. The principles of GPS are not discussed; rather the attention is directed towards general concepts and comparative advantages. A short introduction to the problems faced in kinematics is presented. The intention is to relate the basic principles of kinematics to probably the most used navigation method in the future-INS/GPS. An example of the airborne INS is presented, with emphasis on how it works. The discussion of the error types and sources in navigation, and of the role of filters in optimal estimation of the errors then follows. The main question this paper is trying to answer is 'What are the benefits of the integration of INS and GPS and how is this, navigation concept of the future achieved in reality?' The main goal is to communicate the idea about what stands behind a modern navigation method.

  13. Entropy in Postmerger and Acquisition Integration from an Information Technology Perspective

    ERIC Educational Resources Information Center

    Williams, Gloria S.

    2012-01-01

    Mergers and acquisitions have historically experienced failure rates from 50% to more than 80%. Successful integration of information technology (IT) systems can be the difference between postmerger success or failure. The purpose of this phenomenological study was to explore the entropy phenomenon during postmerger IT integration. To that end, a…

  14. Path-integral approach to 't Hooft's derivation of quantum physics from classical physics

    SciTech Connect

    Blasone, Massimo; Jizba, Petr; Kleinert, Hagen

    2005-05-15

    We present a path-integral formulation of 't Hooft's derivation of quantum physics from classical physics. The crucial ingredient of this formulation is Gozzi et al.'s supersymmetric path integral of classical mechanics. We quantize explicitly two simple classical systems: the planar mathematical pendulum and the Roessler dynamical system.

  15. Calculation of optical depths from an integral of the Voigt function

    NASA Technical Reports Server (NTRS)

    Milman, A. S.

    1978-01-01

    The optical depth along a vertical path in an atmosphere in hydrostatic equilibrium can be calculated from an integral of the Voigt function for the case where the absorption is due to spectral lines. Series expansions are presented that allow rapid evaluation of this integral over all values of the independent variables, frequency and pressure.

  16. Audiovisual Speech Integration in Pervasive Developmental Disorder: Evidence from Event-Related Potentials

    ERIC Educational Resources Information Center

    Magnee, Maurice J. C. M.; de Gelder, Beatrice; van Engeland, Herman; Kemner, Chantal

    2008-01-01

    Background: Integration of information from multiple sensory sources is an important prerequisite for successful social behavior, especially during face-to-face conversation. It has been suggested that communicative impairments among individuals with pervasive developmental disorders (PDD) might be caused by an inability to integrate synchronously…

  17. Process integration possibilities for biodiesel production from palm oil using ethanol obtained from lignocellulosic residues of oil palm industry.

    PubMed

    Gutiérrez, Luis F; Sánchez, Oscar J; Cardona, Carlos A

    2009-02-01

    In this paper, integration possibilities for production of biodiesel and bioethanol using a single source of biomass as a feedstock (oil palm) were explored through process simulation. The oil extracted from Fresh Fruit Bunches was considered as the feedstock for biodiesel production. An extractive reaction process is proposed for transesterification reaction using in situ produced ethanol, which is obtained from two types of lignocellulosic residues of palm industry (Empty Fruit Bunches and Palm Press Fiber). Several ways of integration were analyzed. The integration of material flows between ethanol and biodiesel production lines allowed a reduction in unit energy costs down to 3.4%, whereas the material and energy integration leaded to 39.8% decrease of those costs. The proposed integrated configuration is an important option when the technology for ethanol production from biomass reaches such a degree of maturity that its production costs be comparable with those of grain or cane ethanol. PMID:18930392

  18. Fuels from Biomass: Integration with Food and Materials Systems

    ERIC Educational Resources Information Center

    Lipinsky, E. S.

    1978-01-01

    The development of fuels from biomass can lead naturally to dispersed facilities that incorporate food or materials production (or both) with fuel production. The author analyzes possible systems based on sugarcane, corn, and guayule. (Author/MA)

  19. Integrated method for extracting nickel and vanadium compounds from oils

    SciTech Connect

    Overfield, R.E.

    1987-02-17

    A method is described for the extraction of vanadium or nickel metaloporphyrinic compounds from an oil containing such compounds. The method comprises contacting oil with a solvent selected from the group of gammabutyrolactone, acetonitrile, phenol, furfural, 2-pyrrolidinones, dimethylsulfone, dimethylformamide, pyridine-water mixtures, ethylene carbonate, propylene carbonate, ethylene trithiocarbonate, and dimethyl sulfone to produce a solvent-metalloporphyrinic compound stream and a demetallated product oil stream, regenerating the solvent-metalloporphyrinic stream by contacting it with a highly aromatic oil stream.

  20. FUGITIVE EMISSIONS FROM INTEGRATED IRON AND STEEL PLANTS

    EPA Science Inventory

    The report gives results of an engineering investigation of fugitive (non-ducted) emissions in the iron and steel industry. Operations excluded from the study are coke ovens, basic oxygen furnace (BOF) charging, and blast furnace cast houses. Fugitive emission factors for iron an...

  1. Integration in Academic Reference Departments: From Print to Digital Resources

    ERIC Educational Resources Information Center

    Levrault, Bethany R.

    2005-01-01

    Reference services are in the midst of evolutionary changes. At a time when budgets are shrinking, traditional models of service and print reference formats are being questioned. This article discusses future directions of academic reference collections in terms of the apparent shift from print to electronic reference sources. Questions addressed…

  2. Human Processing of Knowledge from Texts: Acquisition, Integration, and Reasoning.

    ERIC Educational Resources Information Center

    Thorndyke, Perry W.; Hayes-Roth, Barbara

    This report documents a series of studies on how undergraduate students learn from and reason with textual information. The studies described were undertaken to produce models that could serve as the basis for designing computer systems capable of structuring and presenting text material in optimal formats. Divided into sections, the report…

  3. The ventriloquist effect results from near-optimal bimodal integration.

    PubMed

    Alais, David; Burr, David

    2004-02-01

    Ventriloquism is the ancient art of making one's voice appear to come from elsewhere, an art exploited by the Greek and Roman oracles, and possibly earlier. We regularly experience the effect when watching television and movies, where the voices seem to emanate from the actors' lips rather than from the actual sound source. Originally, ventriloquism was explained by performers projecting sound to their puppets by special techniques, but more recently it is assumed that ventriloquism results from vision "capturing" sound. In this study we investigate spatial localization of audio-visual stimuli. When visual localization is good, vision does indeed dominate and capture sound. However, for severely blurred visual stimuli (that are poorly localized), the reverse holds: sound captures vision. For less blurred stimuli, neither sense dominates and perception follows the mean position. Precision of bimodal localization is usually better than either the visual or the auditory unimodal presentation. All the results are well explained not by one sense capturing the other, but by a simple model of optimal combination of visual and auditory information. PMID:14761661

  4. Efficient ethanol recovery from yeast fermentation broth with integrated distillation-membrane process

    EPA Science Inventory

    A hybrid process integrating vapor stripping with vapor compression and vapor permeation membrane separation, termed Membrane Assisted Vapor Stripping (MAVS), was evaluated for recovery and dehydration of ethanol from aqueous solution as an alternative to conventional distillatio...

  5. Comparison of Integrated AOP Systems for BTEX Removal From Solution

    SciTech Connect

    Peters, Robert W.; Mohammad, Jan

    2004-03-31

    This paper investigates the removal of BTEX compounds (benzene, toluene, ethylbenzene and xylene) from water using different advanced oxidation processes (AOPs) used singly or in combination with one another. This research is an extension of our work performed under the Environmental Management Science Program (EMSP) which addressed treating chlorinated organic contaminated water using sonication, vapor stripping and combined sonication + vapor stripping. In our current study, various AOP processes were investigated for their ability to remove BTEX compounds from solution, including the following. ? Ultraviolet (UV) light alone ? UV light + hydrogen peroxide (H2O2) ? Sonication alone ? Air sparging alone ? Air sparging + sonication ? Air sparging + UV light ? Sonication + UV light ? Sonication + H2O2 ? Sonication + air sparging + UV light ? Sonication + air sparging + H2O2 ? Sonication + air sparging + H2O2 + UV light ? Sonication + air sparging with O3 ? Sonication + O3 + H2O2 ? Sonication + O3 + H2O2 + UV light

  6. WABASH RIVER INTEGRATED METHANOL AND POWER PRODUCTION FROM CLEAN COAL TECHNOLOGIES (IMPPCCT)

    SciTech Connect

    Albert Tsang

    2003-03-14

    The Wabash River Integrated Methanol and Power Production from Clean Coal Technologies (IMPPCCT) project is evaluating integrated electrical power generation and methanol production through clean coal technologies. The project is conducted by a multi-industry team lead by Gasification Engineering Corporation (GEC), a company of Global Energy Inc., and supported by Air Products and Chemicals, Inc., Dow Chemical Company, Dow Corning Corporation, Methanex Corporation, and Siemens Westinghouse Power Corporation. Three project phases are planned for execution over several years, including: (1) Feasibility study and conceptual design for an integrated demonstration facility, and for fence-line commercial embodiment plants (CEP) operated at Dow Chemical or Dow Corning chemical plant locations (2) Research, development, and testing to define any technology gaps or critical design and integration issues (3) Engineering design and financing plan to install an integrated commercial demonstration facility at the existing Wabash River Energy Limited (WREL) plant in West Terre Haute, Indiana.

  7. From r-spin intersection numbers to Hodge integrals

    NASA Astrophysics Data System (ADS)

    Ding, Xiang-Mao; Li, Yuping; Meng, Lingxian

    2016-01-01

    Generalized Kontsevich Matrix Model (GKMM) with a certain given potential is the partition function of r-spin intersection numbers. We represent this GKMM in terms of fermions and expand it in terms of the Schur polynomials by boson-fermion correspondence, and link it with a Hurwitz partition function and a Hodge partition by operators in a widehat{GL}(∞) group. Then, from a W 1+∞ constraint of the partition function of r-spin intersection numbers, we get a W 1+∞ constraint for the Hodge partition function. The W 1+∞ constraint completely determines the Schur polynomials expansion of the Hodge partition function.

  8. MINING INTEGRAL ACTINIDES CROSS SECTIONS FROM REACTOR DATA

    SciTech Connect

    PUIGH RJ

    2009-09-11

    The conclusions of this paper are: (1) mining of actinide cross-sections from reactor data is a viable and inexpensive approach to confirm burn-up codes; (2) extensive data for actinides in Hanford test data ({approx} 200 radiochemical analyses); (3) not only cross-section values and reaction rates can be established but also possible benchmark like data can be constructed to test and validate reactor and criticality safety codes such as SCALE/KENO or MCNPX; and (4) analysis along multiple transmutation paths can be evaluated to show consistency.

  9. From mechanisms to function: an integrated framework of animal innovation.

    PubMed

    Tebbich, Sabine; Griffin, Andrea S; Peschl, Markus F; Sterelny, Kim

    2016-03-19

    Animal innovations range from the discovery of novel food types to the invention of completely novel behaviours. Innovations can give access to new opportunities, and thus enable innovating agents to invade and create novel niches. This in turn can pave the way for morphological adaptation and adaptive radiation. The mechanisms that make innovations possible are probably as diverse as the innovations themselves. So too are their evolutionary consequences. Perhaps because of this diversity, we lack a unifying framework that links mechanism to function. We propose a framework for animal innovation that describes the interactions between mechanism, fitness benefit and evolutionary significance, and which suggests an expanded range of experimental approaches. In doing so, we split innovation into factors (components and phases) that can be manipulated systematically, and which can be investigated both experimentally and with correlational studies. We apply this framework to a selection of cases, showing how it helps us ask more precise questions and design more revealing experiments. PMID:26926285

  10. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology

    PubMed Central

    Guggenheim, Alena G.; Wright, Kirsten M.; Zwickey, Heather L.

    2014-01-01

    This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor. These mushrooms were selected based on the body of research performed on mushroom immunology in an oncology model. First, this article focuses on how mushrooms modify cytokines within specific cancer models and on how those cytokines affect the disease process. Second, this article examines the direct effect of mushrooms on cancer. Finally, this article presents an analysis of how mushrooms interact with chemotherapeutic agents, including their effects on its efficacy and on the myelosuppression that results from it. For these 5 mushrooms, an abundance of in vitro evidence exists that elucidates the anticancer immunological mechanisms. Preliminary research in humans is also available and is promising for treatment. PMID:26770080

  11. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology.

    PubMed

    Guggenheim, Alena G; Wright, Kirsten M; Zwickey, Heather L

    2014-02-01

    This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor. These mushrooms were selected based on the body of research performed on mushroom immunology in an oncology model. First, this article focuses on how mushrooms modify cytokines within specific cancer models and on how those cytokines affect the disease process. Second, this article examines the direct effect of mushrooms on cancer. Finally, this article presents an analysis of how mushrooms interact with chemotherapeutic agents, including their effects on its efficacy and on the myelosuppression that results from it. For these 5 mushrooms, an abundance of in vitro evidence exists that elucidates the anticancer immunological mechanisms. Preliminary research in humans is also available and is promising for treatment. PMID:26770080

  12. From mechanisms to function: an integrated framework of animal innovation

    PubMed Central

    Tebbich, Sabine; Griffin, Andrea S.; Peschl, Markus F.; Sterelny, Kim

    2016-01-01

    Animal innovations range from the discovery of novel food types to the invention of completely novel behaviours. Innovations can give access to new opportunities, and thus enable innovating agents to invade and create novel niches. This in turn can pave the way for morphological adaptation and adaptive radiation. The mechanisms that make innovations possible are probably as diverse as the innovations themselves. So too are their evolutionary consequences. Perhaps because of this diversity, we lack a unifying framework that links mechanism to function. We propose a framework for animal innovation that describes the interactions between mechanism, fitness benefit and evolutionary significance, and which suggests an expanded range of experimental approaches. In doing so, we split innovation into factors (components and phases) that can be manipulated systematically, and which can be investigated both experimentally and with correlational studies. We apply this framework to a selection of cases, showing how it helps us ask more precise questions and design more revealing experiments. PMID:26926285

  13. Integration and beyond: linking information from disparate sources and into workflow.

    PubMed

    Stead, W W; Miller, R A; Musen, M A; Hersh, W R

    2000-01-01

    The vision of integrating information-from a variety of sources, into the way people work, to improve decisions and process-is one of the cornerstones of biomedical informatics. Thoughts on how this vision might be realized have evolved as improvements in information and communication technologies, together with discoveries in biomedical informatics, and have changed the art of the possible. This review identified three distinct generations of "integration" projects. First-generation projects create a database and use it for multiple purposes. Second-generation projects integrate by bringing information from various sources together through enterprise information architecture. Third-generation projects inter-relate disparate but accessible information sources to provide the appearance of integration. The review suggests that the ideas developed in the earlier generations have not been supplanted by ideas from subsequent generations. Instead, the ideas represent a continuum of progress along the three dimensions of workflow, structure, and extraction. PMID:10730596

  14. Integrative energy-systems design: System structure from thermodynamic optimization

    NASA Astrophysics Data System (ADS)

    Ordonez, Juan Carlos

    This thesis deals with the application of thermodynamic optimization to find optimal structure and operation conditions of energy systems. Chapter 1 outlines the thermodynamic optimization of a combined power and refrigeration system subject to constraints. It is shown that the thermodynamic optimum is reached by distributing optimally the heat exchanger inventory. Chapter 2 considers the maximization of power extraction from a hot stream in the presence of phase change. It shows that when the receiving (cold) stream boils in a counterflow heat exchanger, the thermodynamic optimization consists of locating the optimal capacity rate of the cold stream. Chapter 3 shows that the main architectural features of a counterflow heat exchanger can be determined based on thermodynamic optimization subject to volume constraint. Chapter 4 addresses two basic issues in the thermodynamic optimization of environmental control systems (ECS) for aircraft: realistic limits for the minimal power requirement, and design features that facilitate operation at minimal power consumption. Several models of the ECS-Cabin interaction are considered and it is shown that in all the models the temperature of the air stream that the ECS delivers to the cabin can be optimized for operation at minimal power. In chapter 5 it is shown that the sizes (weights) of heat and fluid flow systems that function on board vehicles such as aircraft can be derived from the maximization of overall (system level) performance. Chapter 6 develops analytically the optimal sizes (hydraulic diameters) of parallel channels that penetrate and cool a volume with uniformly distributed internal heat generation and Chapter 7 shows analytically and numerically how an originally uniform flow structure transforms itself into a nonuniform one when the objective is to minimize global flow losses. It is shown that flow maldistribution and the abandonment of symmetry are necessary for the development of flow structures with

  15. Insights to integrated river management from a geomorphological viewpoint

    NASA Astrophysics Data System (ADS)

    Valyrakis, Manousos; Liu, Da

    2016-04-01

    In the context of increasing magnitude and frequency of extreme hydrologic events, eco-hydraulic engineers have a dual role of providing novel designs that both help stabilise river systems, as well as help effectively route floodwater safely downstream, though the catchment. One of such soft and green measures commonly used in engineering to protect channel banks and floodplains, is riverbank vegetation. Riverbank vegetation can be of high importance both in preserving the form (morphology) and function (ecology) of our natural as well as engineered river systems. Here the results of an experimental flume study, investigating riverbank hydrodynamics are presented. The effect of different riverbank vegetation densities on flow hydrodynamics across the channel are reported and discussed. Flow diagnostics including mean and turbulent intensity flow profiles along the streamwise and lateral directions, are being assessed via acoustic Doppler velocimetry (ADV) both at the main channel and within the riverbank. The configuration of vegetation elements follows a linear or staggered arrangement as vegetation density is progressively increased. Implications for sediment transport are discussed by considering the change in near-bed shear stresses at the main channel (increasing) and riverbank (decreasing) as the riverbank density increases. As such processes have the potential to affect both the form and function of the river system, the insights from this study are of significant importance to geomorphologists and hydraulic engineers, as well as ecologists.

  16. GDH Integral on the Proton from Cross Section Differences

    SciTech Connect

    Alexander Skabelin

    2002-02-01

    We studied the inclusive reaction {rvec e} {rvec p} {yields} e{prime}X with a 2.5 GeV and a 4.2 GeV incident beam of polarized electrons. The virtual photon four momentum squared, Q{sup 2}, varied from 0.2 GeV{sup 2}/c{sup 2} to 1 GeV{sup 2}/c{sup 2} and the center of mass total energy W ranged up to 2 GeV. The measurement was performed at the CEBAF Large Acceptance Spectrometer (CLAS) of the Thomas Jefferson National Accelerator Facility during the Fall of 1998. A cryogenic NH{sub 3} target was used as a source of protons polarized in the direction of the incident electron beam. For the first time, proton spin structure functions were studied with precision in the resonance region. The data indicate that a dramatic change in the spin structure occurs between the deep inelastic high Q{sup 2} region and the region of low Q{sup 2} where photons become nearly real.

  17. Integrating messages from the eating disorders field into obesity prevention.

    PubMed

    Neumark-Sztainer, Dianne

    2012-12-01

    Weight-related problems, including unhealthy weight control behaviors, binge eating, overweight and obesity, and eating disorders, are prevalent in youth. Furthermore, many young people exhibit more than one of these problems. Therefore, it is essential to consider how to simultaneously work toward the prevention of a broad range of weight-related problems in youth. Dieting, body dissatisfaction, weight talk, and weight-related teasing are commonly addressed risk factors within eating disorder prevention interventions, whereas low levels of physical activity and high intakes of foods high in fat and sugar are commonly addressed within interventions aimed at obesity prevention. Empirical data to be presented in this article demonstrate why risk factors such as dieting and body dissatisfaction, which are typically addressed within the eating disorder field, need to also be addressed within the obesity field. Although dieting and body dissatisfaction strongly predict weight gain over time, these findings are not always taken into account in the design of obesity interventions for youth. Possible reasons as to why risk factors such as dieting, body dissatisfaction, and weight stigmatization may be not adequately addressed within interventions addressing obesity are discussed. Suggestions for how physicians and other nonphysician clinicians might link messages from the fields of both eating disorders and obesity into their work with youth are provided. Finally, the potential for work on mindfulness and yoga to decrease risk factors for both eating disorders and obesity are explored. PMID:23437686

  18. Line drawing extraction from gray level images by feature integration

    NASA Astrophysics Data System (ADS)

    Yoo, Hoi J.; Crevier, Daniel; Lepage, Richard; Myler, Harley R.

    1994-10-01

    We describe procedures that extract line drawings from digitized gray level images, without use of domain knowledge, by modeling preattentive and perceptual organization functions of the human visual system. First, edge points are identified by standard low-level processing, based on the Canny edge operator. Edge points are then linked into single-pixel thick straight- line segments and circular arcs: this operation serves to both filter out isolated and highly irregular segments, and to lump the remaining points into a smaller number of structures for manipulation by later stages of processing. The next stages consist in linking the segments into a set of closed boundaries, which is the system's definition of a line drawing. According to the principles of Gestalt psychology, closure allows us to organize the world by filling in the gaps in a visual stimulation so as to perceive whole objects instead of disjoint parts. To achieve such closure, the system selects particular features or combinations of features by methods akin to those of preattentive processing in humans: features include gaps, pairs of straight or curved parallel lines, L- and T-junctions, pairs of symmetrical lines, and the orientation and length of single lines. These preattentive features are grouped into higher-level structures according to the principles of proximity, similarity, closure, symmetry, and feature conjunction. Achieving closure may require supplying missing segments linking contour concavities. Choices are made between competing structures on the basis of their overall compliance with the principles of closure and symmetry. Results include clean line drawings of curvilinear manufactured objects. The procedures described are part of a system called VITREO (viewpoint-independent 3-D recognition and extraction of objects).

  19. Illusory Streaks from Corners and Their Perceptual Integration

    PubMed Central

    Roncato, Sergio; Guidi, Stefano; Parlangeli, Oronzo; Battaglini, Luca

    2016-01-01

    Perceptual grouping appears both as organized forms of real figural units and as illusory or “phantom” figures. The phenomenon is visible in the Hermann grid and in configurations which generate color spreading, e.g., “neon effects.” These configurations, generally regular repetitive patterns, appear to be crossed by illusory bands filled with a brighter shade or a colored tinge connecting the various loci of illusory effects. In this work, we explore a particular new illusion showing a grouping effect. It manifests as illusory streaks irradiating from the vertexes of angular contours and connecting pairs of figures nearby. It is only clearly visible when more than one figure is shown, and takes the shape of a net crossing their corners. Although the grouping effect is vivid, the local source of the illusion is completely hidden. Theories explaining this effect as due to the irradiation of illusory streaks (mainly that of Grossberg and Mingolla, 1985a,b) do not fully explain the figural patterns presented here. Illusory effects have already been documented at the angles of various figures, causing them to alter in amplitude and brightness; however, the figure illustrated here appears to have different features and location. Phenomenological observations and an experiment were conducted to assess the role played by geometric and photometric parameters in this illusion. Results showed that sharp angles, in low contrast with the surround, are the main source of the illusion which, however, only becomes visible when at least two figures are close together. These findings are discussed with respect to theories of contour processing and perceptual grouping, and in relation to other illusions. PMID:27445922

  20. Illusory Streaks from Corners and Their Perceptual Integration.

    PubMed

    Roncato, Sergio; Guidi, Stefano; Parlangeli, Oronzo; Battaglini, Luca

    2016-01-01

    Perceptual grouping appears both as organized forms of real figural units and as illusory or "phantom" figures. The phenomenon is visible in the Hermann grid and in configurations which generate color spreading, e.g., "neon effects." These configurations, generally regular repetitive patterns, appear to be crossed by illusory bands filled with a brighter shade or a colored tinge connecting the various loci of illusory effects. In this work, we explore a particular new illusion showing a grouping effect. It manifests as illusory streaks irradiating from the vertexes of angular contours and connecting pairs of figures nearby. It is only clearly visible when more than one figure is shown, and takes the shape of a net crossing their corners. Although the grouping effect is vivid, the local source of the illusion is completely hidden. Theories explaining this effect as due to the irradiation of illusory streaks (mainly that of Grossberg and Mingolla, 1985a,b) do not fully explain the figural patterns presented here. Illusory effects have already been documented at the angles of various figures, causing them to alter in amplitude and brightness; however, the figure illustrated here appears to have different features and location. Phenomenological observations and an experiment were conducted to assess the role played by geometric and photometric parameters in this illusion. Results showed that sharp angles, in low contrast with the surround, are the main source of the illusion which, however, only becomes visible when at least two figures are close together. These findings are discussed with respect to theories of contour processing and perceptual grouping, and in relation to other illusions. PMID:27445922

  1. Mars Reconnaissance Orbiter: Integrating Results From the Primary Science Phase

    NASA Astrophysics Data System (ADS)

    Zurek, R. W.; Smrekar, S. E.

    2008-12-01

    The Mars Reconnaissance Orbiter (MRO) recently completed its one-Mars-year Primary Science Phase, observing the Martian atmosphere, surface and subsurface with 7 science investigations using 6 science instruments and tracking of the spacecraft as it orbited Mars. In addition, an eighth investigation made use of the onboard accelerometers during a 5-month period of MRO aerobraking to characterize upper atmospheric structure. Hallmarks-and challenges-of the MRO science mission have been: 1) unprecedented spatial resolution at all wavelengths used when observing from orbit; 2) coordinated imaging of local areas; and 3) the balancing of mapping, regional survey, and targeted observation of selected locales, frequently including repeat observations for stereo or for change detection. This talk will give an overview of the data return, including coverage in various observing modes, and will review how the various data sets have combined to provide new perspectives in our attempts to understand Mars, its present climate and its past evolution. Examples include the combination of surface compositional and morphologic information--on scales comparable to those examined by a terrestrial field geologist-to understand modification of the surface, revelations of the interior structure of the polar ice caps and of ice-rich deposits elsewhere which illuminate climate changes in recent geologic time, and monitoring of modern day variations, particularly as they reveal seasonal and inter-annual redistribution of dust and water, but also as they characterize ongoing mass wasting and cratering of the surface. Together, these all point to a complex history of change on Mars, with alternating episodes of significant water activity early in the planet's history, but with some water activity occurring in later geologic times, including the modern era.

  2. From integrative disease modeling to predictive, preventive, personalized and participatory (P4) medicine

    PubMed Central

    2013-01-01

    With the significant advancement of high-throughput technologies and diagnostic techniques throughout the past decades, molecular underpinnings of many disorders have been identified. However, translation of patient-specific molecular mechanisms into tailored clinical applications remains a challenging task, which requires integration of multi-dimensional molecular and clinical data into patient-centric models. This task becomes even more challenging when dealing with complex diseases such as neurodegenerative disorders. Integrative disease modeling is an emerging knowledge-based paradigm in translational research that exploits the power of computational methods to collect, store, integrate, model and interpret accumulated disease information across different biological scales from molecules to phenotypes. We argue that integrative disease modeling will be an indispensable part of any P4 medicine research and development in the near future and that it supports the shift from descriptive to causal mechanistic diagnosis and treatment of complex diseases. For each ‘P’ in predictive, preventive, personalized and participatory (P4) medicine, we demonstrate how integrative disease modeling can contribute to addressing the real-world issues in development of new predictive, preventive, personalized and participatory measures. With the increasing recognition that application of integrative systems modeling is the key to all activities in P4 medicine, we envision that translational bioinformatics in general and integrative modeling in particular will continue to open up new avenues of scientific research for current challenges in P4 medicine. PMID:24195840

  3. Multiple Integration of the Heat-Conduction Equation for a Space Bounded From the Inside

    NASA Astrophysics Data System (ADS)

    Kot, V. A.

    2016-03-01

    An N-fold integration of the heat-conduction equation for a space bounded from the inside has been performed using a system of identical equalities with definition of the temperature function by a power polynomial with an exponential factor. It is shown that, in a number of cases, the approximate solutions obtained can be considered as exact because their errors comprise hundredths and thousandths of a percent. The method proposed for N-fold integration represents an alternative to classical integral transformations.

  4. Display of travelling 3D scenes from single integral-imaging capture

    NASA Astrophysics Data System (ADS)

    Martinez-Corral, Manuel; Dorado, Adrian; Hong, Seok-Min; Sola-Pikabea, Jorge; Saavedra, Genaro

    2016-06-01

    Integral imaging (InI) is a 3D auto-stereoscopic technique that captures and displays 3D images. We present a method for easily projecting the information recorded with this technique by transforming the integral image into a plenoptic image, as well as choosing, at will, the field of view (FOV) and the focused plane of the displayed plenoptic image. Furthermore, with this method we can generate a sequence of images that simulates a camera travelling through the scene from a single integral image. The application of this method permits to improve the quality of 3D display images and videos.

  5. Automatic Authorship Detection Using Textual Patterns Extracted from Integrated Syntactic Graphs.

    PubMed

    Gómez-Adorno, Helena; Sidorov, Grigori; Pinto, David; Vilariño, Darnes; Gelbukh, Alexander

    2016-01-01

    We apply the integrated syntactic graph feature extraction methodology to the task of automatic authorship detection. This graph-based representation allows integrating different levels of language description into a single structure. We extract textual patterns based on features obtained from shortest path walks over integrated syntactic graphs and apply them to determine the authors of documents. On average, our method outperforms the state of the art approaches and gives consistently high results across different corpora, unlike existing methods. Our results show that our textual patterns are useful for the task of authorship attribution. PMID:27589740

  6. Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts

    PubMed Central

    Kim, Jonghun; Kim, Kee-Pyo; Lim, Kyung Tae; Lee, Seung Chan; Yoon, Juyong; Song, Guangqi; Hwang, Seon In; Schöler, Hans R.; Cantz, Tobias; Han, Dong Wook

    2015-01-01

    The ability to generate integration-free induced hepatocyte-like cells (iHeps) from somatic fibroblasts has the potential to advance their clinical application. Here, we have generated integration-free, functional, and expandable iHeps from mouse somatic fibroblasts. To elicit this direct conversion, we took advantage of an oriP/EBNA1-based episomal system to deliver a set of transcription factors, Gata4, Hnf1a, and Foxa3, to the fibroblasts. The established iHeps exhibit similar morphology, marker expression, and functional properties to primary hepatocytes. Furthermore, integration-free iHeps prolong the survival of fumarylacetoacetate-hydrolase-deficient (Fah−/−) mice after cell transplantation. Our study provides a novel concept for generating functional and expandable iHeps using a non-viral, non-integrating, plasmid-based system that could facilitate their pharmaceutical and biomedical application. PMID:26503743

  7. Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts.

    PubMed

    Kim, Jonghun; Kim, Kee-Pyo; Lim, Kyung Tae; Lee, Seung Chan; Yoon, Juyong; Song, Guangqi; Hwang, Seon In; Schöler, Hans R; Cantz, Tobias; Han, Dong Wook

    2015-01-01

    The ability to generate integration-free induced hepatocyte-like cells (iHeps) from somatic fibroblasts has the potential to advance their clinical application. Here, we have generated integration-free, functional, and expandable iHeps from mouse somatic fibroblasts. To elicit this direct conversion, we took advantage of an oriP/EBNA1-based episomal system to deliver a set of transcription factors, Gata4, Hnf1a, and Foxa3, to the fibroblasts. The established iHeps exhibit similar morphology, marker expression, and functional properties to primary hepatocytes. Furthermore, integration-free iHeps prolong the survival of fumarylacetoacetate-hydrolase-deficient (Fah(-/-)) mice after cell transplantation. Our study provides a novel concept for generating functional and expandable iHeps using a non-viral, non-integrating, plasmid-based system that could facilitate their pharmaceutical and biomedical application. PMID:26503743

  8. The Integration of Remote Sensing and Socioeconomic Data: Lessons from the Socioeconomic Data and Applications Center

    NASA Astrophysics Data System (ADS)

    de Sherbinin, A. M.; Chen, R. S.

    2014-12-01

    Many of the core research questions of the "anthropocene" are spatial in nature, and require spatial data integration to provide the answers: Where are the people most vulnerable to environmental changes located? How do global environmental changes affect people, ecosystems or production systems in a given location? What are the impacts of human activities in the coastal zone, or mountainous areas, or drylands? This paper provides examples of the integration of remotely sensed biophysical and socioeconomic data that illustrate the benefits of spatial data integration. It also addresses some of the challenges in integrating data developed at different scales and for different purposes, sharing lessons learned from twenty years of operating the NASA Socioeconomic Data and Applications Center (SEDAC). Examples will be drawn from the literature on land use/land cover change, urbanization, disaster risk management, climate impact and vulnerability assessment, and natural resource management.

  9. Integration and Testing Challenges of Small Satellite Missions: Experiences from the Space Technology 5 Project

    NASA Technical Reports Server (NTRS)

    Sauerwein, Timothy A.; Gostomski, Tom

    2007-01-01

    The Space Technology 5(ST5) payload was successfully carried into orbit on an OSC Pegasus XL launch vehicle, which was carried aloft and dropped from the OSC Lockheed L-1011 from Vandenberg Air Force Base March 22,2006, at 9:03 am Eastern time, 6:03 am Pacific time. In order to reach the completion of the development and successful launch of ST 5, the systems integration and test(I&T) team determined that a different approach was required to meet the project requirements rather than the standard I&T approach used for single, room-sized satellites. The ST5 payload, part of NASA's New Millennium Program headquartered at JPL, consisted of three micro satellites (approximately 30 kg each) and the Pegasus Support Structure (PSS), the system that connected the spacecrafts to the launch vehicle and deployed the spacecrafts into orbit from the Pegasus XL launch vehicle. ST5 was a technology demonstration payload, intended to test six (6) new technologies for potential use for future space flights along with demonstrating the ability of small satellites to perform quality science. The main technology was a science grade magnetometer designed to take measurements of the earth's magnetic field. The three spacecraft were designed, integrated, and tested at NASA Goddard Space Flight Center with integration and environmental testing occurring in the Bldg. 7-1 0-15-29. The three spacecraft were integrated and tested by the same I&T team. The I&T Manager determined that there was insufficient time in the schedule to perform the three I&T spacecraft activities in series used standard approaches. The solution was for spacecraft #1 to undergo integration and test first, followed by spacecraft #2 and #3 simultaneously. This simultaneous integration was successful for several reasons. Each spacecraft had a Lead Test Conductor who planned and coordinated their spacecraft through its integration and test activities. One team of engineers and technicians executed the integration of all

  10. Integrated versus stand-alone second generation ethanol production from sugarcane bagasse and trash.

    PubMed

    Dias, Marina O S; Junqueira, Tassia L; Cavalett, Otávio; Cunha, Marcelo P; Jesus, Charles D F; Rossell, Carlos E V; Maciel Filho, Rubens; Bonomi, Antonio

    2012-01-01

    Ethanol production from lignocellulosic materials is often conceived considering independent, stand-alone production plants; in the Brazilian scenario, where part of the potential feedstock (sugarcane bagasse) for second generation ethanol production is already available at conventional first generation production plants, an integrated first and second generation production process seems to be the most obvious option. In this study stand-alone second generation ethanol production from surplus sugarcane bagasse and trash is compared with conventional first generation ethanol production from sugarcane and with integrated first and second generation; simulations were developed to represent the different technological scenarios, which provided data for economic and environmental analysis. Results show that the integrated first and second generation ethanol production process from sugarcane leads to better economic results when compared with the stand-alone plant, especially when advanced hydrolysis technologies and pentoses fermentation are included. PMID:22019267

  11. Integrated Arrays on Silicon at Terahertz Frequencies

    NASA Technical Reports Server (NTRS)

    Chattopadhayay, Goutam; Lee, Choonsup; Jung, Cecil; Lin, Robert; Peralta, Alessandro; Mehdi, Imran; Llombert, Nuria; Thomas, Bertrand

    2011-01-01

    In this paper we explore various receiver font-end and antenna architecture for use in integrated arrays at terahertz frequencies. Development of wafer-level integrated terahertz receiver front-end by using advanced semiconductor fabrication technologies and use of novel integrated antennas with silicon micromachining are reported. We report novel stacking of micromachined silicon wafers which allows for the 3-dimensional integration of various terahertz receiver components in extremely small packages which easily leads to the development of 2- dimensioanl multi-pixel receiver front-ends in the terahertz frequency range. We also report an integrated micro-lens antenna that goes with the silicon micro-machined front-end. The micro-lens antenna is fed by a waveguide that excites a silicon lens antenna through a leaky-wave or electromagnetic band gap (EBG) resonant cavity. We utilized advanced semiconductor nanofabrication techniques to design, fabricate, and demonstrate a super-compact, low-mass submillimeter-wave heterodyne frontend. When the micro-lens antenna is integrated with the receiver front-end we will be able to assemble integrated heterodyne array receivers for various applications such as multi-pixel high resolution spectrometer and imaging radar at terahertz frequencies.

  12. Integration of acupuncture into conventional medicine from health professionals' perspective: A thematic synthesis of qualitative studies.

    PubMed

    García-Escamilla, Esther; Rodríguez-Martín, Beatriz; Martínez-Vizcaíno, Vicente

    2016-03-01

    Acupuncture is a prominent Complementary Medicine. Although health professionals' conceptions of acupuncture may affect its utilisation and integration within conventional medicine, these aspects have not been well studied. The aim of this review was to analyse the integration of acupuncture into conventional medicine from the perspective of health professionals. We conducted a systematic review and a thematic synthesis of qualitative studies that analysed the integration of acupuncture into conventional medicine grounded in participants' perspectives. A systematic search was undertaken in PubMed, Web of Science, the Cochrane Library Plus, Scopus and CINAHL. This review included 18 articles: 6 analysed the viewpoint of physicians, 3 of nurses and 9 comprised different health-related professionals. Most of these studies included healthcare professionals practising acupuncture and took place in sites where the relation between acupuncture and biomedicine is favourable. The most used research techniques were convenience sampling, semi-structured interviews and interpretative approach. The holistic approach of acupuncture and its lack of adverse effects were highlighted by the analysed studies. This led to health professionals encouraging its integration into conventional medicine. The main obstacles perceived for the integration were lack of knowledge and institutional support. In general, acupuncture has been adapted to the biomedical model (often practised in an unsystematic and individual manner), and it is conceived as a supplement of Western medicine. 'Working together' and overcoming the biomedical model are recognised by the participants as key conditions for successful integration of acupuncture. PMID:25788323

  13. Can service integration work for universal health coverage? Evidence from around the globe.

    PubMed

    Lê, Gillian; Morgan, Rosemary; Bestall, Janine; Featherstone, Imogen; Veale, Thomas; Ensor, Tim

    2016-04-01

    Universal health coverage (UHC) is at the heart of the new 2030 Agenda for Sustainable Development. Health service integration is seen by World Health Organization as an essential requirement to achieve UHC. However, to date the debate on service integration has focused on perceived benefits rather than empirical impact. We conducted a global review in a systematic manner searching for empirical outcomes of service integration experiments in UHC countries and those on the path to UHC. Sixty-seven articles and reports were found. We grouped results into a unique integration typology with six categories - medical staff from different disciplines; patients and medical staff; care package for one medical condition; care package for two or more medical conditions; specialist stand-alone services with GP services; community locations. We showed that it is possible to integrate services in different human development contexts delivering positive outcomes for patients and clinicians without incurring additional costs. However, the improved outcomes shown were incremental rather than radical and suggest that integration is likely to enhance already well established systems rather than fundamentally changing the outcomes of care. PMID:27108079

  14. Integration and Testing Challenges of Small, Multiple Satellite Missions: Experiences from the Space Technology 5 Project

    NASA Technical Reports Server (NTRS)

    Sauerwein, Timothy A.; Gostomski, Thomas

    2008-01-01

    The ST5 technology demonstration mission led by GSFC of NASA's New Millennium Program managed by JPL consisted of three micro satellites (approximately 30 kg each) deployed into orbit from the Pegasus XL launch vehicle. In order to meet the launch date schedule of ST5, a different approach was required rather than the standard I&T approach used for single, room-sized satellites. The three spacecraft were designed, integrated, and tested at NASA Goddard Space Flight Center. It was determined that there was insufficient time in the schedule to perform three spacecraft I&T activities in series using standard approaches. The solution was for spacecraft #1 to undergo integration and test first, followed by spacecraft #2 and #3 simultaneously. This simultaneous integration was successful for several reasons. Each spacecraft had a Lead Test Conductor who planned and coordinated their spacecraft through its integration and test activities. One team of engineers and technicians executed the integration of all three spacecraft, learning and gaining knowledge and efficiency as spacecraft #1 integration and testing progressed. They became acutely familiar with the hardware, operation and processes for I&T, thus had the experience and knowledge to safely execute I&T for spacecraft #2 and #3. The integration team was extremely versatile; each member could perform many different activities or work any spacecraft, when needed. ST5 was successfully integrated, tested and shipped to the launch site per the I&T schedule that was planned three years previously. The I&T campaign was completed with ST5's successful launch on March 22, 2006.

  15. Brain Network Analysis: Separating Cost from Topology Using Cost-Integration

    PubMed Central

    Ginestet, Cedric E.; Nichols, Thomas E.; Bullmore, Ed T.; Simmons, Andrew

    2011-01-01

    A statistically principled way of conducting brain network analysis is still lacking. Comparison of different populations of brain networks is hard because topology is inherently dependent on wiring cost, where cost is defined as the number of edges in an unweighted graph. In this paper, we evaluate the benefits and limitations associated with using cost-integrated topological metrics. Our focus is on comparing populations of weighted undirected graphs that differ in mean association weight, using global efficiency. Our key result shows that integrating over cost is equivalent to controlling for any monotonic transformation of the weight set of a weighted graph. That is, when integrating over cost, we eliminate the differences in topology that may be due to a monotonic transformation of the weight set. Our result holds for any unweighted topological measure, and for any choice of distribution over cost levels. Cost-integration is therefore helpful in disentangling differences in cost from differences in topology. By contrast, we show that the use of the weighted version of a topological metric is generally not a valid approach to this problem. Indeed, we prove that, under weak conditions, the use of the weighted version of global efficiency is equivalent to simply comparing weighted costs. Thus, we recommend the reporting of (i) differences in weighted costs and (ii) differences in cost-integrated topological measures with respect to different distributions over the cost domain. We demonstrate the application of these techniques in a re-analysis of an fMRI working memory task. We also provide a Monte Carlo method for approximating cost-integrated topological measures. Finally, we discuss the limitations of integrating topology over cost, which may pose problems when some weights are zero, when multiplicities exist in the ranks of the weights, and when one expects subtle cost-dependent topological differences, which could be masked by cost-integration. PMID:21829437

  16. Integration of Metagenomic and Biogeochemical Data from Soils Sampled from a Long-Term Reciprocal Transplant

    NASA Astrophysics Data System (ADS)

    Bailey, V. L.; Hess, N. J.; McCue, L. A.

    2014-12-01

    The long-term impacts of climate conditions on soil ecosystems are difficult to discern with sufficient resolution to underpin a predictive understanding of ecosystem response to global climate change. The structure and function of the microbial community is intimately linked to soil organic carbon (SOC) by both the deposition of new carbon, and metabolism and respiration of existing SOC. We are studying the resilience of the microbial community, and the vulnerability of the soil carbon reservoirs, to changing climate conditions using a reciprocal soil transplant experiment initiated in 1994 in eastern Washington. Soil cores were reciprocally transplanted between two elevations (310 m and 844 m); the lower site is warmer and drier with 0.8% soil carbon, and the upper site is cooler and wetter with 1.8% soil carbon. We resampled these cores in 2012-13 to analyze the structure of the microbial community, biochemical activities of carbohydrate-active enzymes, and the soil carbon and nitrogen content. We hypothesized that microbial and biochemical dynamics developed under cool, moist conditions would destabilize under hot, dry conditions, such that carbon and nitrogen losses would be faster in warmer climate soils than the accruals in cooler climate soils. Metagenomics data analyses show that the microbial communities below 5 cm depth in the transplanted soils are most similar to those in the native and control soils from their original (pre-1994) location, whereas the surface microbial community has been influenced by their new (post-1994) location. Enzyme activities are highest in soils from the cooler, moister location, and the activities of the reciprocally transplanted soils are shifting toward the activities typical of their new location. Integration of these results with high-resolution mass spectrometry data of the soil carbon moieties will contribute to our fundamental understanding of climate change effects on the terrestrial ecosystem carbon cycle.

  17. Introduction to the Issue on Segregation, Desegregation, and Integration: From History, to Policy, to Practice

    ERIC Educational Resources Information Center

    Diem, Sarah; Brooks, Jeffrey

    2013-01-01

    The articles in this special issue examine the increasingly complex relationship between segregation, desegregation, and integration in a sociopolitical environment vastly different from that of the initial days of desegregation. These issues are examined from historical and political perspectives, contextualizing the complexities of segregation,…

  18. Integration and Publications as Indicators of "Yield" from Mixed Methods Studies

    ERIC Educational Resources Information Center

    O'Cathain, Alicia; Murphy, Elizabeth; Nicholl, Jon

    2007-01-01

    A mixed methods study has the potential to produce knowledge that is unavailable to a qualitative study and a quantitative study undertaken independently. Any unique insight or "yield" from a mixed methods study may be difficult to assess in practice. However, given that integration of data or findings from different components of a study is a…

  19. INTEGRAL caught a new outburst from IGR J17464-3213

    NASA Astrophysics Data System (ADS)

    Ducci, L.; Rodriguez, J.; Grinberg, V.; Kuulkers, E.; Bozzo, E.

    2014-09-01

    During the observation of the Galactic Center performed from 2014 September 13 at 03:25 to September 15 at 04:18 (UTC), the IBIS/ISGRI and JEM-X instruments on board INTEGRAL detected renewed activity from the black-hole candidate IGR J17464-3213 (H 1743-322).

  20. Facilitating Dance Making from a Teacher's Perspective within a Community Integrated Dance Class

    ERIC Educational Resources Information Center

    Cheesman, Sue

    2011-01-01

    Integrated dance has featured in several publications from the mid-1990's onwards, particularly from the standpoints of equity of access, and contesting perceptions of dominant conventional notions of what dance is and who can dance including issues of embodiment and representation. Other publications and manuals focus primarily on how to teach…

  1. A Critical Review of "Learning from the Market: Integrating 'The Stock Market Game' across the Curriculum."

    ERIC Educational Resources Information Center

    Maier, Mark H.

    2002-01-01

    Reviews "Learning from the Market: Integrating 'The Stock Market Game' across the Curriculum" guide for teachers in grades 4 to 12. Believes the guide suffers from errors of fact and omission. Suggests corrections and alternative activities that enable instructors to continue to use the material. (JEH)

  2. Can we estimate total magnetization directions from aeromagnetic data using Helbig's integrals?

    USGS Publications Warehouse

    Phillips, J.D.

    2005-01-01

    An algorithm that implements Helbig's (1963) integrals for estimating the vector components (mx, my, mz) of tile magnetic dipole moment from the first order moments of the vector magnetic field components (??X, ??Y, ??Z) is tested on real and synthetic data. After a grid of total field aeromagnetic data is converted to vector component grids using Fourier filtering, Helbig's infinite integrals are evaluated as finite integrals in small moving windows using a quadrature algorithm based on the 2-D trapezoidal rule. Prior to integration, best-fit planar surfaces must be removed from the component data within the data windows in order to make the results independent of the coordinate system origin. Two different approaches are described for interpreting the results of the integration. In the "direct" method, results from pairs of different window sizes are compared to identify grid nodes where the angular difference between solutions is small. These solutions provide valid estimates of total magnetization directions for compact sources such as spheres or dipoles, but not for horizontally elongated or 2-D sources. In the "indirect" method, which is more forgiving of source geometry, results of the quadrature analysis are scanned for solutions that are parallel to a specified total magnetization direction.

  3. Assessment of the integration capability of system architectures from a complex and distributed software systems perspective

    NASA Astrophysics Data System (ADS)

    Leuchter, S.; Reinert, F.; Müller, W.

    2014-06-01

    Procurement and design of system architectures capable of network centric operations demand for an assessment scheme in order to compare different alternative realizations. In this contribution an assessment method for system architectures targeted at the C4ISR domain is presented. The method addresses the integration capability of software systems from a complex and distributed software system perspective focusing communication, interfaces and software. The aim is to evaluate the capability to integrate a system or its functions within a system-of-systems network. This method uses approaches from software architecture quality assessment and applies them on the system architecture level. It features a specific goal tree of several dimensions that are relevant for enterprise integration. These dimensions have to be weighed against each other and totalized using methods from the normative decision theory in order to reflect the intention of the particular enterprise integration effort. The indicators and measurements for many of the considered quality features rely on a model based view on systems, networks, and the enterprise. That means it is applicable to System-of-System specifications based on enterprise architectural frameworks relying on defined meta-models or domain ontologies for defining views and viewpoints. In the defense context we use the NATO Architecture Framework (NAF) to ground respective system models. The proposed assessment method allows evaluating and comparing competing system designs regarding their future integration potential. It is a contribution to the system-of-systems engineering methodology.

  4. First Results From GLAST-LAT Integrated Towers Cosmic Ray Data Taking And Monte Carlo Comparison

    SciTech Connect

    Brigida, M.; Caliandro, A.; Favuzzi, C.; Fusco, P.; Gargano, F.; Giordano, F.; Giglietto, N.; Loparco, F.; Marangelli, B.; Mazziotta, M.N.; Mirizzi, N.; Raino, S.; Spinelli, P.; /Bari U. /INFN, Bari

    2007-02-15

    GLAST Large Area Telescope (LAT) is a gamma ray telescope instrumented with silicon-strip detector planes and sheets of converter, followed by a calorimeter (CAL) and surrounded by an anticoincidence system (ACD). This instrument is sensitive to gamma rays in the energy range between 20 MeV and 300 GeV. At present, the first towers have been integrated and pre-launch data taking with cosmic ray muons is being performed. The results from the data analysis carried out during LAT integration will be discussed and a comparison with the predictions from the Monte Carlo simulation will be shown.

  5. Heterogeneous integration of epitaxial nanostructures: strategies and application drivers

    NASA Astrophysics Data System (ADS)

    Chui, Chi On; Shin, Kyeong-Sik; Kina, Jorge; Shih, Kun-Huan; Narayanan, Pritish; Moritz, C. Andras

    2012-10-01

    In order to sustain the historic progress in information processing, transmission, and storage, concurrent integration of heterogeneous functionality and materials with fine granularity is clearly imperative for the best connectivity, system performance, and density metrics. In this paper, we review recent developments in heterogeneous integration of epitaxial nanostructures for their applications toward our envisioned device-level heterogeneity using computing nanofabrics. We first identify the unmet need for heterogeneous integration in modern nanoelectronics and review state-of-the-art assembly approaches for nanoscale computing fabrics. We also discuss the novel circuit application driver, known as Nanoscale Application Specific Integrated Circuits (NASICs), which promises an overall performance-power-density advantage over CMOS and embeds built-in defect and parameter variation resilience. At the device-level, we propose an innovative cross-nanowire field-effect transistor (xnwFET) structure that simultaneously offers high performance, low parasitics, good electrostatic control, ease-of-manufacturability, and resilience to process variation. In addition, we specify technology requirements for heterogeneous integration and present two wafer-scale strategies. The first strategy is based on ex situ assembly and stamping transfer of pre-synthesized epitaxial nanostructures that allows tight control over key nanofabric parameters. The second strategy is based on lithographic definition of epitaxial nanostructures on native substrates followed by their stamping transfer using VLSI foundry processes. Finally, we demonstrate the successful concurrent heterogeneous co-integration of silicon and III-V compound semiconductor epitaxial nanowire arrays onto the same hosting substrate over large area, at multiple locations, with fine granularity, close proximity and high yield.

  6. Thermalization in an interacting spin system in the transition from integrability to chaos

    NASA Astrophysics Data System (ADS)

    Relaño, A.

    2010-07-01

    A stringent analysis of nonequilibrium dynamics and thermalization in a complex interacting spin system, which transits from integrability to chaos, is performed. The applicability of both standard thermodynamical ensembles—canonical and microcanonical—and the generalized Gibbs ensemble is tested. The role of constants of motion is studied, and a critical analysis of the usual definition of quantum integrability is performed. Different possible thermalization mechanisms are also analyzed. We find significant discrepancies between the time averages of some observables and the prediction from the thermodynamical ensembles within the ergodic region, so we conclude that quantum chaos does not guarantee thermalization. We also find that quantum integrable dynamics keeps more memory concerning the initial state, which is in part stored in a set of constants of motion that can be explicitly obtained.

  7. Integrating Variable Renewable Energy in Electric Power Markets: Best Practices from International Experience (Fact Sheet)

    SciTech Connect

    Not Available

    2014-10-01

    Many countries--reflecting very different geographies, markets, and power systems--are successfully managing high levels of variable renewable energy (RE) on the grid. Australia (South Australia), Denmark, Germany, Ireland, Spain, and the United States (Colorado and Texas), for example, have effectively integrated variable RE utilizing diverse approaches. Analysis of the results from these case studies reveals a wide range of mechanisms that can be used to accommodate high penetrations of variable RE (e.g., from new market designs to centralized planning). Nevertheless, the myriad approaches collectively suggest that governments can best enable variable RE grid integration by implementing best practices in five areas of intervention: lead public engagement, particularly for new transmission; coordinate and integrate planning; develop rules for market evolution that enable system flexibility; expand access to diverse resources and geographic footprint of operations; and improve system operations.

  8. Propulsion system performance resulting from an integrated flight/propulsion control design

    NASA Technical Reports Server (NTRS)

    Mattern, Duane; Garg, Sanjay

    1992-01-01

    Propulsion-system-specific results are presented from the application of the integrated methodology for propulsion and airframe control (IMPAC) design approach to integrated flight/propulsion control design for a 'short takeoff and vertical landing' (STOVL) aircraft in transition flight. The IMPAC method is briefly discussed and the propulsion system specifications for the integrated control design are examined. The structure of a linear engine controller that results from partitioning a linear centralized controller is discussed. The details of a nonlinear propulsion control system are presented, including a scheme to protect the engine operational limits: the fan surge margin and the acceleration/deceleration schedule that limits the fuel flow. Also, a simple but effective multivariable integrator windup protection scheme is examined. Nonlinear closed-loop simulation results are presented for two typical pilot commands for transition flight: acceleration while maintaining flightpath angle and a change in flightpath angle while maintaining airspeed. The simulation nonlinearities include the airframe/engine coupling, the actuator and sensor dynamics and limits, the protection scheme for the engine operational limits, and the integrator windup protection. Satisfactory performance of the total airframe plus engine system for transition flight, as defined by the specifications, was maintained during the limit operation of the closed-loop engine subsystem.

  9. Demand-Side Management and Integrated Resource Planning: Findings from a Survey of 24 Electric Utilities

    SciTech Connect

    Schweitzer, M.

    1991-01-01

    Integrated resource planning differs from traditional utility planning practices primarily in its increased attention to demand-side management (DSM) programs and its integration of supply- and demand-side resources into a combined resource portfolio. This report details the findings from an Oak Ridge National Laboratory (ORNL) survey of 24 electric utilities that have well-developed integrated planning processes. These utilities account for roughly one-third of total capacity, electricity generation, and DSM-program expenditures nationwide. The ORNL survey was designed to obtain descriptive data on a national sample of utilities and to test a number of hypothesized relationships between selected utility characteristics and the mix of resources selected for the integrated plan, with an emphasis on the use of DSM resources and the processes by which they are chosen. The survey solicited information on each utility's current and projected resource mix, operating environment, procedures used to screen potential DSM resources, techniques used to obtain public input and to integrate supply- and demand-side options into a unified plan, and procedures used in the final selection of resources for the plan.

  10. From Physical Process to Economic Cost - Integrated Approaches of Landslide Risk Assessment

    NASA Astrophysics Data System (ADS)

    Klose, M.; Damm, B.

    2014-12-01

    The nature of landslides is complex in many respects, with landslide hazard and impact being dependent on a variety of factors. This obviously requires an integrated assessment for fundamental understanding of landslide risk. Integrated risk assessment, according to the approach presented in this contribution, implies combining prediction of future landslide occurrence with analysis of landslide impact in the past. A critical step for assessing landslide risk in integrated perspective is to analyze what types of landslide damage affected people and property in which way and how people contributed and responded to these damage types. In integrated risk assessment, the focus is on systematic identification and monetization of landslide damage, and analytical tools that allow deriving economic costs from physical landslide processes are at the heart of this approach. The broad spectrum of landslide types and process mechanisms as well as nonlinearity between landslide magnitude, damage intensity, and direct costs are some main factors explaining recent challenges in risk assessment. The two prevailing approaches for assessing the impact of landslides in economic terms are cost survey (ex-post) and risk analysis (ex-ante). Both approaches are able to complement each other, but yet a combination of them has not been realized so far. It is common practice today to derive landslide risk without considering landslide process-based cause-effect relationships, since integrated concepts or new modeling tools expanding conventional methods are still widely missing. The approach introduced in this contribution is based on a systematic framework that combines cost survey and GIS-based tools for hazard or cost modeling with methods to assess interactions between land use practices and landslides in historical perspective. Fundamental understanding of landslide risk also requires knowledge about the economic and fiscal relevance of landslide losses, wherefore analysis of their

  11. Responses to GM food content in context with food integrity issues: results from Australian population surveys.

    PubMed

    Mohr, Philip; Golley, Sinéad

    2016-01-25

    This study examined community responses to use of genetically modified (GM) content in food in the context of responses to familiar food additives by testing an empirically and theoretically derived model of the predictors of responses to both GM content and food integrity issues generally. A nationwide sample of 849 adults, selected at random from the Australian Electoral Roll, responded to a postal Food and Health Survey. Structural equation modelling analyses confirmed that ratings of general concern about food integrity (related to the presence of preservatives and other additives) strongly predicted negativity towards GM content. Concern about food integrity was, in turn, predicted by environmental concern and health engagement. In addition, both concern about food integrity generally and responses to GM content specifically were weakly predicted by attitudes to benefits of science and an intuitive (i.e., emotionally-based) reasoning style. Data from a follow-up survey conducted under the same conditions (N=1184) revealed that ratings of concern were significantly lower for use of genetic engineering in food than for four other common food integrity issues examined. Whereas the question of community responses to GM is often treated as a special issue, these findings support the conclusion that responses to the concept of GM content in food in Australia are substantially a specific instance of a general sensitivity towards the integrity of the food supply. They indicate that the origins of responses to GM content may be largely indistinguishable from those of general responses to preservatives and other common food additives. PMID:26348278

  12. Nonequilibrium quantum dynamics and transport: from integrability to many-body localization

    NASA Astrophysics Data System (ADS)

    Vasseur, Romain; Moore, Joel E.

    2016-06-01

    We review the non-equilibrium dynamics of many-body quantum systems after a quantum quench with spatial inhomogeneities, either in the Hamiltonian or in the initial state. We focus on integrable and many-body localized systems that fail to self-thermalize in isolation and for which the standard hydrodynamical picture breaks down. The emphasis is on universal dynamics, non-equilibrium steady states and new dynamical phases of matter, and on phase transitions far from thermal equilibrium. We describe how the infinite number of conservation laws of integrable and many-body localized systems lead to complex non-equilibrium states beyond the traditional dogma of statistical mechanics.

  13. Teaching for Civic Engagement: Lesson Learned from Integrating Positive Psychology and Future Studies

    ERIC Educational Resources Information Center

    Allen, Jeanie K.

    2011-01-01

    Teaching for civic education holds promise for assisting colleges and universities that suggest the promotion of global citizenship in their mission statements. This paper presents the study of a course where readings and activities from the literature of positive psychology were integrated with studies about current global issues and potential…

  14. Integrating Vocational & Academic Education. A Handbook Featuring Four Demonstration Sites Including Students from Special Populations.

    ERIC Educational Resources Information Center

    Tindall, Lloyd W.; And Others

    This handbook describes the processes and techniques used to develop, implement, and evaluate four integrated vocational and academic learning programs in Wisconsin that included students from special populations. The handbook contains seven chapters. Chapter 1 presents an overview of the project, including the request for proposal process and…

  15. Do Integrated Children's Services Improve Children's Outcomes?: Evidence from England's Children's Trust Pathfinders

    ERIC Educational Resources Information Center

    O'Brien, Margaret; Bachmann, Max O.; Jones, Natalia R.; Reading, Richard; Thoburn, June; Husbands, Chris; Shreeve, Ann; Watson, Jacqueline

    2009-01-01

    Thirty-five children's trust pathfinders, local cross-sector partnerships, were introduced across England in 2003 to promote greater integration in children's services. Using administrative performance data, this paper tracks yearly trends in child service outputs and child well-being outcomes from 1997 to 2004 in these local areas, including the…

  16. Understanding Introductory Students' Application of Integrals in Physics from Multiple Perspectives

    ERIC Educational Resources Information Center

    Hu, Dehui

    2013-01-01

    Calculus is used across many physics topics from introductory to upper-division level college courses. The concepts of differentiation and integration are important tools for solving real world problems. Using calculus or any mathematical tool in physics is much more complex than the straightforward application of the equations and algorithms that…

  17. INTEGRAL/JEM-X reports enhanced activity from the HMXB 4U 1036-56

    NASA Astrophysics Data System (ADS)

    Chenevez, J.; Fiocchi, M.; Bazzano, A.; Natalucci, L.; Ubertini, P.; Sguera, V.; Kuulkers, E.

    2015-12-01

    During the Galactic Plane Scanning performed by INTEGRAL on December 11th, 2015, the X-ray monitor JEM-X has detected enhanced activity from the high mass X-ray binary (HMXB) 4U 1036-56, aka RX J1037.5-5647.

  18. Desegregation/Integration and the Media: Fallout from the Brown Decision in West Virginia.

    ERIC Educational Resources Information Center

    Chilton, W. E., III

    This paper provides an anecdotal account of racial relations and integration efforts in West Virginia before and after the Brown decision, from the perspective of the publisher of the "Charleston Gazette," The struggle for racial equality in West Virginia has been filled with contradictions. The first legal action taken in West Virginia against a…

  19. The Graduate Outcome Project: Using Data from the Integrated Data Infrastructure Project

    ERIC Educational Resources Information Center

    Rees, Malcolm

    2014-01-01

    This paper reports on progress to date with a project underway in New Zealand involving the extraction of data from multiple government agencies that is then combined into one comprehensive longitudinal integrated dataset and made available to trial participants in a way never previously thought possible. The dataset includes school leaver…

  20. Lessons from the Desert: Integrating Managerial Expertise and Learning for Organizational Transformation

    ERIC Educational Resources Information Center

    Roth, George

    2004-01-01

    Reflection upon a field study of a corporate transformation provides insights into the application and integration of organizational learning theory and frameworks with local, corporate knowledge. In the corporate transformation studied this local knowledge came from consumer psychology, marketing campaigns and the use of media. When these ideas…

  1. From collision to collaboration - Integrating informal recyclers and re-use operators in Europe: A review.

    PubMed

    Scheinberg, Anne; Nesić, Jelena; Savain, Rachel; Luppi, Pietro; Sinnott, Portia; Petean, Flaviu; Pop, Flaviu

    2016-09-01

    The European Union hosts some of the world's most developed waste management systems and an ambitious policy commitment to the circular economy. The existence of informal recycling and re-use activities in Europe has been vigorously denied until quite recently, and remains a very challenging subject for the European solid waste management sector, as well as for European government and private institutions. In countries ranging from Malta to Macedonia and from France to Turkey, informal recyclers excluded from legal recycling niches increasingly collide with formalised and controlled European Union approaches to urban waste management, packaging recovery schemes, formal re-use enterprises, and extended producer responsibility systems.This review focuses on the period from 2004 through the first half of 2016. The 78 sources on European (and neighbouring) informal recycling and re-use are contextualised with global sources and experience. The articles focus on informal recovery in and at the borders of the European Union, document the conflicts and collisions, and elaborate some constructive approaches towards legalisation, integration, and reconciliation. The overarching recommendation, to locate the issue of informal recovery and integration in the framework of the European circular economy package, is supported by four specific pillars of an integration strategy: Documentation, legalisation, occupational and enterprise recognition, and preparation for structural integration. PMID:27449318

  2. Understanding the Language Demands on Science Students from an Integrated Science and Language Perspective

    ERIC Educational Resources Information Center

    Seah, Lay Hoon; Clarke, David John; Hart, Christina Eugene

    2014-01-01

    This case study of a science lesson, on the topic thermal expansion, examines the language demands on students from an integrated science and language perspective. The data were generated during a sequence of 9 lessons on the topic of "States of Matter" in a Grade 7 classroom (12-13 years old students). We identify the language demands…

  3. AD/HD Is a Bio-Psychosocial Condition Requiring Support from Integrated Services

    ERIC Educational Resources Information Center

    Hughes, Lesley

    2007-01-01

    This article reports on how integrated services can provide coordinated support for children with AD/HD and their families. The author reports on the effectiveness of a problem-based approach to interagency working by exploring the use of two models of good practice from education, health and social care to provide a framework for working across…

  4. Recalibration of the multisensory temporal window of integration results from changing task demands.

    PubMed

    Mégevand, Pierre; Molholm, Sophie; Nayak, Ashabari; Foxe, John J

    2013-01-01

    The notion of the temporal window of integration, when applied in a multisensory context, refers to the breadth of the interval across which the brain perceives two stimuli from different sensory modalities as synchronous. It maintains a unitary perception of multisensory events despite physical and biophysical timing differences between the senses. The boundaries of the window can be influenced by attention and past sensory experience. Here we examined whether task demands could also influence the multisensory temporal window of integration. We varied the stimulus onset asynchrony between simple, short-lasting auditory and visual stimuli while participants performed two tasks in separate blocks: a temporal order judgment task that required the discrimination of subtle auditory-visual asynchronies, and a reaction time task to the first incoming stimulus irrespective of its sensory modality. We defined the temporal window of integration as the range of stimulus onset asynchronies where performance was below 75% in the temporal order judgment task, as well as the range of stimulus onset asynchronies where responses showed multisensory facilitation (race model violation) in the reaction time task. In 5 of 11 participants, we observed audio-visual stimulus onset asynchronies where reaction time was significantly accelerated (indicating successful integration in this task) while performance was accurate in the temporal order judgment task (indicating successful segregation in that task). This dissociation suggests that in some participants, the boundaries of the temporal window of integration can adaptively recalibrate in order to optimize performance according to specific task demands. PMID:23951203

  5. Integration of Sentence-Level Semantic Information in Parafovea: Evidence from the RSVP-Flanker Paradigm.

    PubMed

    Zhang, Wenjia; Li, Nan; Wang, Xiaoyue; Wang, Suiping

    2015-01-01

    During text reading, the parafoveal word was usually presented between 2° and 5° from the point of fixation. Whether semantic information of parafoveal words can be processed during sentence reading is a critical and long-standing issue. Recently, studies using the RSVP-flanker paradigm have shown that the incongruent parafoveal word, presented as right flanker, elicited a more negative N400 compared with the congruent parafoveal word. This suggests that the semantic information of parafoveal words can be extracted and integrated during sentence reading, because the N400 effect is a classical index of semantic integration. However, as most previous studies did not control the word-pair congruency of the parafoveal and the foveal words that were presented in the critical triad, it is still unclear whether such integration happened at the sentence level or just at the word-pair level. The present study addressed this question by manipulating verbs in Chinese sentences to yield either a semantically congruent or semantically incongruent context for the critical noun. In particular, the interval between the critical nouns and verbs was controlled to be 4 or 5 characters. Thus, to detect the incongruence of the parafoveal noun, participants had to integrate it with the global sentential context. The results revealed that the N400 time-locked to the critical triads was more negative in incongruent than in congruent sentences, suggesting that parafoveal semantic information can be integrated at the sentence level during Chinese reading. PMID:26418230

  6. Exploring the role of ICT in the provision of integrated care--evidence from eight countries.

    PubMed

    Lluch, Maria; Abadie, Fabienne

    2013-06-01

    This research aimed to identify the role of telehealthcare in the provision of integrated care in thirty-one experiences across eight different European countries, namely: Denmark, Estonia, Germany, France, Italy, Netherlands, Spain and the UK. Experiences were analysed from three perspectives: diffusion of innovations, governance and impact, which led to the identification of a set of drivers and barriers for widespread deployment. The analysis also found that telehealthcare developments were strongly in line with developments towards the delivery of integrated care and thus support this process. Factors which contribute to the successful delivery of integrated care, such as aligned incentives, sound governance and evidence consolidation, were identified across the most successful experiences. Although the decision to mainstream telehealthcare will remain a value judgement, the analysis of best practices across experiences allowed us to identify factors which could enable decision makers to assess both the state of maturity of the health and social care environments and their readiness to scale up. PMID:23587547

  7. An integrated detoxification process with electrodialysis and adsorption from the hemicellulose hydrolysates of yellow poplars.

    PubMed

    Trinh, Ly Thi Phi; Kundu, Chandan; Lee, Jae-Won; Lee, Hong-Joo

    2014-06-01

    An integrated detoxification process with electrodialysis (ED) followed by adsorption was performed to remove fermentation inhibitors from hemicellulose hydrolysates. The hydrolysates were prepared by oxalic acid pretreatment of yellow poplars at different temperatures. Of fermentation inhibitors, acetic acid showed high removal efficiency of about 90% and high transport rate during the ED process without membrane fouling. The integration of the detoxification processes increased up to the ethanol yield of 0.33g/g sugar, the ethanol production of about 9g/L, and the productivity of 0.12g/Lh, while the fermentation of non-detoxified hydrolysates did not produce bioethanol. The influence of inhibitor concentration on the fermentability showed that HMF had the highest inhibition effect. The results clearly showed that an integrated detoxification process with ED followed by adsorption removed fermentation inhibitors with high efficiency and increased the fermentability of the oxalic acid pretreated hemicellulose hydrolysates. PMID:24713602

  8. Multidimensional integration through Markovian sampling under steered function morphing: A physical guise from statistical mechanics

    NASA Astrophysics Data System (ADS)

    Zerbetto, Mirco; Frezzato, Diego

    2015-10-01

    We present a computational strategy for the evaluation of multidimensional integrals on hyper-rectangles based on Markovian stochastic exploration of the integration domain while the integrand is being morphed by starting from an initial appropriate profile. Thanks to an abstract reformulation of Jarzynski's equality applied in stochastic thermodynamics to evaluate the free-energy profiles along selected reaction coordinates via non-equilibrium transformations, it is possible to cast the original integral into the exponential average of the distribution of the pseudo-work (that we may term "computational work") involved in doing the function morphing, which is straightforwardly solved. Several tests illustrate the basic implementation of the idea, and show its performance in terms of computational time, accuracy and precision. The formulation for integrand functions with zeros and possible sign changes is also presented.

  9. Suppressed visual looming stimuli are not integrated with auditory looming signals: Evidence from continuous flash suppression

    PubMed Central

    Moors, Pieter; Huygelier, Hanne; Wagemans, Johan; de-Wit, Lee; van Ee, Raymond

    2015-01-01

    Previous studies using binocular rivalry have shown that signals in a modality other than the visual can bias dominance durations depending on their congruency with the rivaling stimuli. More recently, studies using continuous flash suppression (CFS) have reported that multisensory integration influences how long visual stimuli remain suppressed. In this study, using CFS, we examined whether the contrast thresholds for detecting visual looming stimuli are influenced by a congruent auditory stimulus. In Experiment 1, we show that a looming visual stimulus can result in lower detection thresholds compared to a static concentric grating, but that auditory tone pips congruent with the looming stimulus did not lower suppression thresholds any further. In Experiments 2, 3, and 4, we again observed no advantage for congruent multisensory stimuli. These results add to our understanding of the conditions under which multisensory integration is possible, and suggest that certain forms of multisensory integration are not evident when the visual stimulus is suppressed from awareness using CFS. PMID:26034573

  10. Enhanced light emission from carbon nanotubes integrated in silicon micro-resonator

    NASA Astrophysics Data System (ADS)

    Noury, Adrien; Le Roux, Xavier; Vivien, Laurent; Izard, Nicolas

    2015-08-01

    Single-walled carbon nanotubes are considered a fascinating nanomaterial for photonic applications and are especially promising for efficient light emitters in the telecommunication wavelength range. Furthermore, their hybrid integration with silicon photonic structures makes them an ideal platform to explore their intrinsic properties. Here we report on the strong photoluminescence enhancement from carbon nanotubes integrated in silicon ring resonator circuits under two pumping configurations: surface-illuminated pumping at 735 nm and collinear pumping at 1.26 μ {{m}}. Extremely efficient rejection of the non-resonant photoluminescence was obtained. In the collinear approach, an emission efficiency enhancement by a factor of 26 has been demonstrated in comparison with the classical pumping scheme. This demonstration paves the way for the development of integrated light sources in silicon based on carbon nanotubes.

  11. Shuttle Program Loads Integration: Going From Concept to Operations and Staying Successful

    NASA Technical Reports Server (NTRS)

    Bernstein, Karen; James, George; Mackey, alden; Murphy, Neil C.; Brolliar, Steve

    2011-01-01

    From the beginning of the Shuttle Program to its end, integrated loads and dynamics analyses and tests have been critical in shaping the vehicle design and operational decisions for NASA and its customers. Starting with scaled models and simple mathematical simulations of the structural dynamics, engineers defined the required structural stiffness and predicted the limit loads for each element of the system. Early structural tests provided reasonable confidence that the models and predictions were good. The first launch of the Space Shuttle brought surprises, though, when the ignition overpressure event caused a forward fuel tank support strut to buckle, among several unexpected effects. The launch pad and other ground equipment became an integral part of the system integration, especially where the acoustic and pressure environments of ignition and lift-off were concerned. Following the Challenger accident, operating limits were changed in response to new understandings of how the integrated system performed. Controlling loads while maximizing performance was a key tenet of the Performance Enhancement design process, which enabled construction of the International Space Station. During the return to flight after the Columbia accident, engineers grew to understand that loads during the roll maneuver were also important to the vehicle s structural margin and life. At this point the crawler transport from the Vehicle Assembly Building to the launch pad also became a part of the integrated loads analysis. Even in the last years of the Space Shuttle Program, new data still provided interesting insights into this complicated and fascinating spaceship. This paper will present some examples of the important findings by the team of specialists that supported the Integrated Loads and Dynamics Panel for the Space Shuttle Program.

  12. Connections: A Compendium of Integration Ideas. Illinois Tech Prep Innovators. 1992 Compendium. Integrative Teaching Ideas from Illinois Teachers.

    ERIC Educational Resources Information Center

    Illinois State Board of Education, Springfield. Dept. of Adult, Vocational and Technical Education.

    This report contains 51 one-page abstracts of innovative Illinois tech prep programs that integrate academic and vocational education. Each abstract includes the following: curriculum areas, grade level, types of students for whom the program is appropriate, materials needed, suggested resources, a contact person with address and telephone number,…

  13. On the integration of financial markets: How strong is the evidence from five international stock markets?

    NASA Astrophysics Data System (ADS)

    Bentes, Sónia R.

    2015-07-01

    This paper examines the integration of financial markets using data from five international stock markets in the context of globalization. The theoretical basis of this study relies on the price theory and the Law of One Price, which was adjusted to the framework of financial markets. When price levels are nonstationary, cointegration and the error correction model constitute a powerful tool for the empirical examination of market integration. The error correction model provides a fully dynamic framework that allows to separating the long and the short run effects of the integration process. A dataset encompassing the daily stock price series of the PSI 20 (Portugal), IBEX 35 (Spain), FTSE 100 (UK), NIKKEI 225 (Japan) and SP 500 (US) indices from January 4th 1999 to September 19th 2014 is employed. The results highlight that these five stock markets are linked together by just one long-run relationship, although short-run movements are also present, which causes distinct deviations from the long-run equilibrium relationship. Endogeneity prevails in the system as a whole. While market integration in the sense of the Law of One Price holds, pairwise full price transmission has limited evidence. The results therefore show that stock market price movements are highly nonlinear and complex.

  14. Integrated Microbial Genomes (IMG) System from the DOE Joint Genome Institute (JGI)

    DOE Data Explorer

    The integrated microbial genomes (IMG) system is a data management, analysis and annotation platform for all publicly available genomes. IMG contains both draft and complete JGI microbial genomes integrated with all other publicly available genomes from all three domains of life, together with a large number of plasmids and viruses. IMG provides tools and viewers for analyzing and annotating genomes, genes and functions, individually or in a comparative context. Since its first release in 2005, IMG's data content and analytical capabilities have been constantly expanded through quarterly releases. IMG is provided by the DOE-Joint Genome Institute (JGI) and is available from http://img.jgi.doe.gov. [Abstract from The integrated microbial genomes (IMG) system in 2007: data content and analysis tool extensions; Victor M. Markowitz, Ernest Szeto, Krishna Palaniappan, Yuri Grechkin, Ken Chu, I-Min A. Chen, Inna Dubchak, Iain Anderson, Athanasios Lykidis, Konstantinos Mavromatis, Natalia N. Ivanova and Nikos C. Kyrpides; Nucleic Acids Research, 2008, Vol. 36. (Database Issue) See also the companion system, Integrated Microbial Genomes with Microbiome Samples.

  15. Directed Self-Assembly of Triblock Copolymer on Chemical Patterns for Sub-10-nm Nanofabrication via Solvent Annealing.

    PubMed

    Xiong, Shisheng; Wan, Lei; Ishida, Yoshihito; Chapuis, Yves-Andre; Craig, Gordon S W; Ruiz, Ricardo; Nealey, Paul F

    2016-08-23

    Directed self-assembly (DSA) of block copolymers (BCPs) is a leading strategy to pattern at sublithographic resolution in the technology roadmap for semiconductors and is the only known solution to fabricate nanoimprint templates for the production of bit pattern media. While great progress has been made to implement block copolymer lithography with features in the range of 10-20 nm, patterning solutions below 10 nm are still not mature. Many BCP systems self-assemble at this length scale, but challenges remain in simultaneously tuning the interfacial energy atop the film to control the orientation of BCP domains, designing materials, templates, and processes for ultra-high-density DSA, and establishing a robust pattern transfer strategy. Among the various solutions to achieve domains that are perpendicular to the substrate, solvent annealing is advantageous because it is a versatile method that can be applied to a diversity of materials. Here we report a DSA process based on chemical contrast templates and solvent annealing to fabricate 8 nm features on a 16 nm pitch. To make this possible, a number of innovations were brought in concert with a common platform: (1) assembling the BCP in the phase-separated, solvated state, (2) identifying a larger process window for solvated triblock vs diblock BCPs as a function of solvent volume fraction, (3) employing templates for sub-10-nm BCP systems accessible by lithography, and (4) integrating a robust pattern transfer strategy by vapor infiltration of organometallic precursors for selective metal oxide synthesis to prepare an inorganic hard mask. PMID:27482932

  16. Learning from graphically integrated 2D and 3D representations improves retention of neuroanatomy

    NASA Astrophysics Data System (ADS)

    Naaz, Farah

    Visualizations in the form of computer-based learning environments are highly encouraged in science education, especially for teaching spatial material. Some spatial material, such as sectional neuroanatomy, is very challenging to learn. It involves learning the two dimensional (2D) representations that are sampled from the three dimensional (3D) object. In this study, a computer-based learning environment was used to explore the hypothesis that learning sectional neuroanatomy from a graphically integrated 2D and 3D representation will lead to better learning outcomes than learning from a sequential presentation. The integrated representation explicitly demonstrates the 2D-3D transformation and should lead to effective learning. This study was conducted using a computer graphical model of the human brain. There were two learning groups: Whole then Sections, and Integrated 2D3D. Both groups learned whole anatomy (3D neuroanatomy) before learning sectional anatomy (2D neuroanatomy). The Whole then Sections group then learned sectional anatomy using 2D representations only. The Integrated 2D3D group learned sectional anatomy from a graphically integrated 3D and 2D model. A set of tests for generalization of knowledge to interpreting biomedical images was conducted immediately after learning was completed. The order of presentation of the tests of generalization of knowledge was counterbalanced across participants to explore a secondary hypothesis of the study: preparation for future learning. If the computer-based instruction programs used in this study are effective tools for teaching anatomy, the participants should continue learning neuroanatomy with exposure to new representations. A test of long-term retention of sectional anatomy was conducted 4-8 weeks after learning was completed. The Integrated 2D3D group was better than the Whole then Sections

  17. Integrative analysis of T cell motility from multi-channel microscopy data using TIAM.

    PubMed

    Mayya, Viveka; Neiswanger, Willie; Medina, Ricardo; Wiggins, Chris H; Dustin, Michael L

    2015-01-01

    Integrative analytical approaches are needed to study and understand T cell motility as it is a highly coordinated and complex process. Several computational algorithms and tools are available to track motile cells in time-lapse microscopy images. In contrast, there has only been limited effort towards the development of tools that take advantage of multi-channel microscopy data and facilitate integrative analysis of cell-motility. We have implemented algorithms for detecting, tracking, and analyzing cell motility from multi-channel time-lapse microscopy data. We have integrated these into a MATLAB-based toolset we call TIAM (Tool for Integrative Analysis of Motility). The cells are detected by a hybrid approach involving edge detection and Hough transforms from transmitted light images. Cells are tracked using a modified nearest-neighbor association followed by an optimization routine to join shorter segments. Cell positions are used to perform local segmentation for extracting features from transmitted light, reflection and fluorescence channels and associating them with cells and cell-tracks to facilitate integrative analysis. We found that TIAM accurately captures the motility behavior of T cells and performed better than DYNAMIK, Icy, Imaris, and Volocity in detecting and tracking motile T cells. Extraction of cell-associated features from reflection and fluorescence channels was also accurate with less than 10% median error in measurements. Finally, we obtained novel insights into T cell motility that were critically dependent on the unique capabilities of TIAM. We found that 1) the CD45RO subset of human CD8 T cells moved faster and exhibited an increased propensity to attach to the substratum during CCL21-driven chemokinesis when compared to the CD45RA subset; and 2) attachment area and arrest coefficient during antigen-induced motility of the CD45A subset is correlated with surface density of integrin LFA1 at the contact. PMID:25445324

  18. Fully Integrated Approach to Compute Vibrationally Resolved Optical Spectra: From Small Molecules to Macrosystems.

    PubMed

    Barone, Vincenzo; Bloino, Julien; Biczysko, Malgorzata; Santoro, Fabrizio

    2009-03-10

    A general and effective time-independent approach to compute vibrationally resolved electronic spectra from first principles has been integrated into the Gaussian computational chemistry package. This computational tool offers a simple and easy-to-use way to compute theoretical spectra starting from geometry optimization and frequency calculations for each electronic state. It is shown that in such a way it is straightforward to combine calculation of Franck-Condon integrals with any electronic computational model. The given examples illustrate the calculation of absorption and emission spectra, all in the UV-vis region, of various systems from small molecules to large ones, in gas as well as in condensed phases. The computational models applied range from fully quantum mechanical descriptions to discrete/continuum quantum mechanical/molecular mechanical/polarizable continuum models. PMID:26610221

  19. Integrated Biomarker Responses of Effluents from Municipal Sewage Treatment Works in Goldfish

    NASA Astrophysics Data System (ADS)

    Lu, G. H.; Xia, J.; Zhang, H. Z.; Wang, C.

    2010-11-01

    The organic toxicants were extracted from the effluents from municipal sewage treatment works (STWs) in Nanjing (Chengbei, Suojincun and Jiangxinzhou STWs) by using solid phase extraction. AChE, GST, EROD, GPx and Na+/K+-ATPase activities in goldfish (Carassius auratus) were determmed after exposure of the extracted components. The extracts of water samples from the three STWs induced AChE, GST, EROD and Na+/K+-ATPase activities. The responses of enzymatic activities were mostly significant for those exposures of intermediate polar components, weakly polar components and/or nonpolar hexane extracts. Integrated biomarker response (IBR) index were calculated and used to evaluate an integrated impact of organic toxicants from different sampling sites. The order of negative biological effects of the three STWs was Jiangxinzhou>Chengbei>Suojincun.

  20. Preservice Teachers' Capacity to Teach Self-Regulated Learning: Integrating Learning from Problems and Learning from Successes

    ERIC Educational Resources Information Center

    Michalsky, Tova; Schechter, Chen

    2013-01-01

    Using a quasi-experimental design, we integrated systematic learning from problematic and successful experiences into teachers' preparatory programs and examined how such learning affected preservice physics teachers' capacity to teach students self-regulated learning (SRL). Results indicated that preservice teachers who contemplated both…

  1. Parallel preparation of plan-view transmission electron microscopy specimens by vapor-phase etching with integrated etch stops.

    PubMed

    English, Timothy S; Provine, J; Marshall, Ann F; Koh, Ai Leen; Kenny, Thomas W

    2016-07-01

    Specimen preparation remains a practical challenge in transmission electron microscopy and frequently limits the quality of structural and chemical characterization data obtained. Prevailing methods for thinning of specimens to electron transparency are serial in nature, time consuming, and prone to producing artifacts and specimen failure. This work presents an alternative method for the preparation of plan-view specimens using isotropic vapor-phase etching with integrated etch stops. An ultrathin amorphous etch-stop layer simultaneously serves as an electron transparent support membrane whose thickness is defined by a controlled growth process such as atomic layer deposition with sub-nanometer precision. This approach eliminates the need for mechanical polishing or ion milling to achieve electron transparency, and reduces the occurrence of preparation induced artifacts. Furthermore, multiple specimens from a plurality of samples can be thinned in parallel due to high selectivity of the vapor-phase etching process. These features enable dramatic reductions in preparation time and cost without sacrificing specimen quality and provide advantages over wet etching techniques. Finally, we demonstrate a platform for high-throughput transmission electron microscopy of plan-view specimens by combining the parallel preparation capabilities of vapor-phase etching with wafer-scale micro- and nanofabrication. PMID:27160487

  2. Measurements of Integration Gain for the Cospas-Sarsat System from Geosynchronous Satellites

    NASA Technical Reports Server (NTRS)

    Klein-Lebbink, Elizabeth; Christo, James; Peters, Robert; Nguyen, Xuan

    2015-01-01

    The GOES-R satellite is the first satellite to use a standard straight bent pipe transponder with no on-board re-modulation to support Search and Rescue (SAR) operations. Here, we report on the link measurements with a high fidelity satellite transponder simulator made up of satellite EDU (Engineering Design Units) components using an uplink from a beacon simulator and received by a GEOLUT (GEOsynchronous satellite Local User Terminal). We also report on the first ever measurements showing the performance gain obtained by the signal integration performed by the GEOLUT. In addition, a simulator made of commercially available off-the-shelf components assembled to develop the test plan was found to perform very close to the high fidelity simulator. In this paper, we describe what message integration is, how it is implemented in the particular satellite receiving station model used for this tests, and show the measured improvement in message decoding due to this integration process. These are the first tests to quantify the integration gain and are the first tests on the new SARSAT standard for the bent pipe (no onboard re-modulation) repeater used in GOES-R. An inexpensive satellite simulator to run test scripts built from off the shelf components was also found to have the same performance as a high fidelity simulator using actual satellite EDUs.

  3. Land cover data from Landsat single-date archive imagery: an integrated classification approach

    NASA Astrophysics Data System (ADS)

    Bajocco, Sofia; Ceccarelli, Tomaso; Rinaldo, Simone; De Angelis, Antonella; Salvati, Luca; Perini, Luigi

    2012-10-01

    The analysis of land cover dynamics provides insight into many environmental problems. However, there are few data sources which can be used to derive consistent time series, remote sensing being one of the most valuable ones. Due to their multi-temporal and spatial coverage needs, such analysis is usually based on large land cover datasets, which requires automated, objective and repeatable procedures. The USGS Landsat archives provide free access to multispectral, high-resolution remotely sensed data starting from the mid-eighties; in many cases, however, only single date images are available. This paper suggests an objective approach for generating land cover information from 30m resolution and single date Landsat archive satellite imagery. A procedure was developed integrating pixel-based and object-oriented classifiers, which consists of the following basic steps: i) pre-processing of the satellite image, including radiance and reflectance calibration, texture analysis and derivation of vegetation indices, ii) segmentation of the pre-processed image, iii) its classification integrating both radiometric and textural properties. The integrated procedure was tested for an area in Sardinia Region, Italy, and compared with a purely pixel-based one. Results demonstrated that a better overall accuracy, evaluated against the available land cover cartography, was obtained with the integrated (86%) compared to the pixel-based classification (68%) at the first CORINE Land Cover level. The proposed methodology needs to be further tested for evaluating its trasferability in time (constructing comparable land cover time series) and space (for covering larger areas).

  4. The integrated enstrophy budget of the winter stratosphere diagnosed from LIMS data

    NASA Technical Reports Server (NTRS)

    Schoeberl, M. R.; Smith, A. K.

    1985-01-01

    The quasi-geostrophic integrated enstrophy budget for the 1978 to 1979 winter has been analyzed from 10-0.1 mb using LIMS data. During January and late February periods a significant imbalance in the budget appears at 10mb. This imbalance is attributed to Rossby wave breaking. It is produced by the irreversible transfer of enstrophy to smaller scales not resolved by LIMS. The imbalance episodes correspond well to the appearance of Ertel vorticity filaments shown by McIntyre and Palmer (1984). From a seasonal viewpoint, the integrated enstrophy shows an average (although irregular) transfer from a zonal mean reservoir to waves which are then dissipated. On a shorter time scale the integrated enstrophy sloshes back and forth between the waves and mean flow in early winter; then, beginning with the January sudden warming, the total enstrophy is reduced more rapidly. Between 10 mb and 1 mb this reduction is more or less continuous until the end of February. However, in the mesosphere the total enstrophy decrease is very short lived, being quickly restored after the January warming. Even though the zonal mean integrated enstrophy is large, only about 10% can be utilized by the waves. The available integrated potential enstrophy is introduced, which is a better measure of how close the flow is to saturation by Rossby waves. The largest amount of available potential enstrophy in early January is at 1 mb with decreasing amounts above and below. Saturation of the flow by Rossby waves occurs below 1 mb only coincident with sudden warmings; however, at mesospheric heights the flow appears to be nearly saturated throughout the winter.

  5. Reward Maximization Justifies the Transition from Sensory Selection at Childhood to Sensory Integration at Adulthood

    PubMed Central

    Daee, Pedram; Mirian, Maryam S.; Ahmadabadi, Majid Nili

    2014-01-01

    In a multisensory task, human adults integrate information from different sensory modalities -behaviorally in an optimal Bayesian fashion- while children mostly rely on a single sensor modality for decision making. The reason behind this change of behavior over age and the process behind learning the required statistics for optimal integration are still unclear and have not been justified by the conventional Bayesian modeling. We propose an interactive multisensory learning framework without making any prior assumptions about the sensory models. In this framework, learning in every modality and in their joint space is done in parallel using a single-step reinforcement learning method. A simple statistical test on confidence intervals on the mean of reward distributions is used to select the most informative source of information among the individual modalities and the joint space. Analyses of the method and the simulation results on a multimodal localization task show that the learning system autonomously starts with sensory selection and gradually switches to sensory integration. This is because, relying more on modalities -i.e. selection- at early learning steps (childhood) is more rewarding than favoring decisions learned in the joint space since, smaller state-space in modalities results in faster learning in every individual modality. In contrast, after gaining sufficient experiences (adulthood), the quality of learning in the joint space matures while learning in modalities suffers from insufficient accuracy due to perceptual aliasing. It results in tighter confidence interval for the joint space and consequently causes a smooth shift from selection to integration. It suggests that sensory selection and integration are emergent behavior and both are outputs of a single reward maximization process; i.e. the transition is not a preprogrammed phenomenon. PMID:25058591

  6. An integrated process for the extraction of fuel and chemicals from marine macroalgal biomass

    PubMed Central

    Trivedi, Nitin; Baghel, Ravi S.; Bothwell, John; Gupta, Vishal; Reddy, C. R. K.; Lali, Arvind M.; Jha, Bhavanath

    2016-01-01

    We describe an integrated process that can be applied to biomass of the green seaweed, Ulva fasciata, to allow the sequential recovery of four economically important fractions; mineral rich liquid extract (MRLE), lipid, ulvan, and cellulose. The main benefits of our process are: a) its simplicity and b) the consistent yields obtained from the residual biomass after each successive extraction step. For example, dry Ulva biomass yields ~26% of its starting mass as MRLE, ~3% as lipid, ~25% as ulvan, and ~11% as cellulose, with the enzymatic hydrolysis and fermentation of the final cellulose fraction under optimized conditions producing ethanol at a competitive 0.45 g/g reducing sugar. These yields are comparable to those obtained by direct processing of the individual components from primary biomass. We propose that this integration of ethanol production and chemical feedstock recovery from macroalgal biomass could substantially enhance the sustainability of marine biomass use. PMID:27470705

  7. An integrated process for the extraction of fuel and chemicals from marine macroalgal biomass.

    PubMed

    Trivedi, Nitin; Baghel, Ravi S; Bothwell, John; Gupta, Vishal; Reddy, C R K; Lali, Arvind M; Jha, Bhavanath

    2016-01-01

    We describe an integrated process that can be applied to biomass of the green seaweed, Ulva fasciata, to allow the sequential recovery of four economically important fractions; mineral rich liquid extract (MRLE), lipid, ulvan, and cellulose. The main benefits of our process are: a) its simplicity and b) the consistent yields obtained from the residual biomass after each successive extraction step. For example, dry Ulva biomass yields ~26% of its starting mass as MRLE, ~3% as lipid, ~25% as ulvan, and ~11% as cellulose, with the enzymatic hydrolysis and fermentation of the final cellulose fraction under optimized conditions producing ethanol at a competitive 0.45 g/g reducing sugar. These yields are comparable to those obtained by direct processing of the individual components from primary biomass. We propose that this integration of ethanol production and chemical feedstock recovery from macroalgal biomass could substantially enhance the sustainability of marine biomass use. PMID:27470705

  8. Research integrity in greater China: surveying regulations, perceptions and knowledge of research integrity from a Hong Kong perspective.

    PubMed

    Jordan, Sara R; Gray, Phillip W

    2013-12-01

    In their 2010 article 'Research Integrity in China: Problems and Prospects', Zeng and Resnik challenge others to engage in empirical research on research integrity in China. Here we respond to that call in three ways: first, we provide updates to their analysis of regulations and allegations of scientific misconduct; second, we report on two surveys conducted in Hong Kong that provide empirical backing to describe ways in which problems and prospects that Zeng and Resnik identify are being explored; and third, we continue the discussion started by Zeng and Resnik, pointing to ways in which China's high-profile participation in international academic research presents concerns about research integrity. According to our research, based upon searches of both English and Chinese language literature and policies, and two surveys conducted in Hong Kong, academic faculty and research post-graduate students in Hong Kong are aware of and have a positive attitude towards responsible conduct of research. Although Hong Kong is but one small part of China, we present this research as a response to concerns Zeng and Resnik introduce and as a call for a continued conversation. PMID:22994886

  9. [Declared dead? Recommendations regarding integrated care from the perspective of German statutory health insurance].

    PubMed

    Amelung, Volker; Wolf, S; Ozegowski, S; Eble, S; Hildebrandt, H; Knieps, F; Lägel, R; Schlenker, R-U; Sjuts, R

    2015-04-01

    The traditional separation of health care into sectors in Germany causes communication problems that hinder continuous, patient-oriented care. This is most evident in the transition from inpatient to outpatient care. That said, there are also breaks in the flow of information, a lack of supply, or even incorrect information flowing within same-sector care. The transition from a division of functions into sectors to a patient-oriented process represents a change in the paradigm of health care that can only be successfully completed with considerable effort. Germany's statutory health insurance (SHI) funds play a key role here, as they are the contracting parties as well as the financiers of integrated care, and are strategically located at the center of the development process.The objective of this article is to explore how Germany's SHI funds view integrated care, what they regard as being the drivers of and barriers to transitioning to such a system, and what recommendations they can provide with regard to the further development of integrated care. For this purpose semi-structured interviews with board members and those responsible for implementing integrated care into the operations of ten SHI funds representing more than half of Germany's SHI-insured population were conducted. According to the interviewees, a better framework for integrated care urgently needs to be developed and rendered more receptive to innovation.Only in this way will the widespread stagnation of the past several years be overcome. The deregulation of § 140a-d SGB V and the establishment of a uniform basis for new forms of care in terms of a new innovation clause are among the central recommendations of this article. The German federal government's innovation fund was met with great hope, but also implied risks. Nonetheless, the new law designed to strengthen health care overall generated high expectations. PMID:25776522

  10. Integration of different data bodies for humanitarian decision support: an example from mine action.

    PubMed

    Benini, Aldo A; Conley, Charles E; Shdeed, Richard; Spurway, Kim; Yarmoshuk, Mark

    2003-12-01

    Geographic information systems (GIS) are increasingly used for integrating data from different sources and substantive areas, including in humanitarian action. The challenges of integration are particularly well illustrated by humanitarian mine action. The informational requirements of mine action are expensive, with socio-economic impact surveys costing over US$1.5 million per country, and are feeding a continuous debate on the merits of considering more factors or 'keeping it simple'. National census offices could, in theory, contribute relevant data, but in practice surveys have rarely overcome institutional obstacles to external data acquisition. A positive exception occurred in Lebanon, where the landmine impact survey had access to agricultural census data. The challenges, costs and benefits of this data integration exercise are analysed in a detailed case study. The benefits are considerable, but so are the costs, particularly the hidden ones. The Lebanon experience prompts some wider reflections. In the humanitarian community, data integration has been fostered not only by the diffusion of GIS technology, but also by institutional changes such as the creation of UN-led Humanitarian Information Centres. There is a question whether the analytic capacity is in step with aggressive data acquisition. Humanitarian action may yet have to build the kind of strong analytic tradition that public health and poverty alleviation have accomplished. PMID:14725088

  11. Novel word integration in the mental lexicon: evidence from unmasked and masked semantic priming.

    PubMed

    Tamminen, Jakke; Gaskell, M Gareth

    2013-01-01

    We sought to establish whether novel words can become integrated into existing semantic networks by teaching participants new meaningful words and then using these new words as primes in two semantic priming experiments, in which participants carried out a lexical decision task to familiar words. Importantly, at no point in training did the novel words co-occur with the familiar words that served as targets in the primed lexical decision task, allowing us to evaluate semantic priming in the absence of direct association. We found that familiar words were primed by the newly related novel words, both when the novel word prime was unmasked (experiment 1) and when it was masked (experiment 2), suggesting that the new words had been integrated into semantic memory. Furthermore, this integration was strongest after a 1-week delay and was independent of explicit recall of the novel word meanings: Forgetting of meanings did not attenuate priming. We argue that even after brief training, newly learned words become an integrated part of the adult mental lexicon rather than being episodically represented separately from the lexicon. PMID:23035665

  12. Community-oriented integrated care and health promotion – views from the street

    PubMed Central

    Thomas, Paul; Burch, Tony; Ferlie, Ewan; Jenkins, Rachel; Wright, Fiona; Sachar, Amrit; Ruprah-Shah, Baljeet

    2015-01-01

    Abstract On the 1st and 2nd May 2015, participants at the RCGP London City Health Conference debated practical ways to achieve integrated care at community level. In five connected workshops, participants reviewed current work and identified ways to overcome some of the problems that had become apparent. In this paper, we summarise the conclusions of each workshop, and provide an overall comment. There are layers of complexity in community-oriented integrated care that are not apparent at first sight. The difficult thing is not persuading people that it matters, but finding ways to do it that are practical and sustainable. The dynamic and complex nature of the territory is bewildering. The expectation of silo-operating and linear thinking, and the language and models that encourage it, pervade health and social care. Comprehensive integration is possible, but the theory and practice are unfamiliar to many. Images, theories and models are needed to help people from all parts of the system to see big pictures and focused detail at the same time and oscillate between them to envision-integrated whole systems. Infrastructure needs to enable this, with coordination hubs, locality-based multidisciplinary meetings and cycles of inter-organisational improvement to nurture relationships across organisational boundaries. PMID:26550036

  13. Integration and Testing Challenges of Small, Multiple Satellite Missions: Experiences from the Space Technology 5 Project

    NASA Technical Reports Server (NTRS)

    Sauerwein, Timothy A.; Gostomski, Thomas

    2007-01-01

    The ST5 payload, part of NASA s New Millennium Program headquartered at JPL, consisted of three micro satellites (approx. 30 kg each) deployed into orbit from the Pegasus XL launch. ST5 was a technology demonstration mission, intended to test new technologies for potential use for future missions. In order to meet the launch date schedule of ST 5, a different approach was required rather than the standard I&T approach used for single, room-sized satellites. The I&T phase was planned for spacecraft #1 to undergo integration and test first, followed by spacecraft #2 and #3 in tandem. A team of engineers and technicians planned and executed the integration of all three spacecraft emphasizing versatility and commonality. They increased their knowledge and efficiency through spacecraft #1 integration and testing and utilized their experience and knowledge to safely execute I&T for spacecraft #2 and #3. Each integration team member could perform many different roles and functions and thus better support activities on any of the three spacecraft. The I&T campaign was completed with STS s successful launch on March 22,2006

  14. From polarisation to practice: puzzles and insights on integrated approaches from public health professionals.

    PubMed

    Buffardi, Anne L

    2014-01-01

    Much of the debate in the global health literature about vertical and horizontal programmatic approaches, between narrowly targeted interventions and those providing broader system-wide support, has taken place at the global level. Based on a comparative case study of international donors in the health sector in Peru that varied in their vertical-horizontal orientation, this article examines the extent to which health care practitioners and national policy-makers perceive and attempt to reconcile the tension between these approaches. Informants readily identified advantages and disadvantages of both approaches, but did not perceive a marked vertical-horizontal division, suggesting that tensions appear to be less pronounced in practice than academic debates suggest. A clear consensus did not emerge, and although more people spoke of a mixed approached, they too puzzled over how best to balance trade-offs. In practice, there were examples of more integrated approaches, targeted aspects of horizontal programmes and system-strengthening elements of vertical programmes; however, they were not explicitly identified as such. Practitioner perspectives reinforced the diverse and dynamic nature of disease, both epidemics and country profiles, and suggest that focusing on periods of transition and points of integration may be a fruitful path forward. PMID:24992263

  15. Integrative Approach for Producing Hydrogen and Polyhydroxyalkanoate from Mixed Wastes of Biological Origin.

    PubMed

    Patel, Sanjay K S; Lee, Jung-Kul; Kalia, Vipin C

    2016-09-01

    In this study, an integrative approach to produce biohydrogen (H2) and polyhydroxyalkanoates (PHA) from the wastes of biological origin was investigated. A defined set of mixed cultures was used for hydrolysis and the hydrolysates were used to produce H2. The effluent from H2 production stage was used for PHA production. Under batch culture, a maximum of 62 l H2/kg of pure potato peels (Total solid, TS 2 %, w/v) and 54 l H2/kg of mixed biowastes (MBW1) was recorded. Using effluent from the H2 production stage of biowaste mixture (MBW1), Bacillus cereus EGU43 could produce 195 mg PHA/l and 15.6 % (w/w). Further, supplementation of GM-2 medium (0.1×) and glucose (0.5 %) in H2 production stage effluents, resulted in significant improvements of up to 11 and 41.7 % of PHA contents, respectively. An improvement of 3.9- and 17-fold in PHA yields as compared to with and without integrative H2 production from the MBW1 has been recorded. This integrative approach seems to be a suitable process to improve the yields of H2 and PHA by mixing biowastes. PMID:27407293

  16. MSblender: a probabilistic approach for integrating peptide identifications from multiple database search engines

    PubMed Central

    Kwon, Taejoon; Choi, Hyungwon; Vogel, Christine; Nesvizhskii, Alexey I.; Marcotte, Edward M.

    2011-01-01

    Shotgun proteomics using mass spectrometry is a powerful method for protein identification but suffers limited sensitivity in complex samples. Integrating peptide identifications from multiple database search engines is a promising strategy to increase the number of peptide identifications and reduce the volume of unassigned tandem mass spectra. Existing methods pool statistical significance scores such as p-values or posterior probabilities of peptide-spectrum matches (PSMs) from multiple search engines after high scoring peptides have been assigned to spectra, but these methods lack reliable control of identification error rates as data are integrated from different search engines. We developed a statistically coherent method for integrative analysis, termed MSblender. MSblender converts raw search scores from search engines into a probability score for all possible PSMs and properly accounts for the correlation between search scores. The method reliably estimates false discovery rates and identifies more PSMs than any single search engine at the same false discovery rate. Increased identifications increment spectral counts for all detected proteins and allow quantification of proteins that would not have been quantified by individual search engines. We also demonstrate that enhanced quantification contributes to improve sensitivity in differential expression analyses. PMID:21488652

  17. MSblender: A probabilistic approach for integrating peptide identifications from multiple database search engines.

    PubMed

    Kwon, Taejoon; Choi, Hyungwon; Vogel, Christine; Nesvizhskii, Alexey I; Marcotte, Edward M

    2011-07-01

    Shotgun proteomics using mass spectrometry is a powerful method for protein identification but suffers limited sensitivity in complex samples. Integrating peptide identifications from multiple database search engines is a promising strategy to increase the number of peptide identifications and reduce the volume of unassigned tandem mass spectra. Existing methods pool statistical significance scores such as p-values or posterior probabilities of peptide-spectrum matches (PSMs) from multiple search engines after high scoring peptides have been assigned to spectra, but these methods lack reliable control of identification error rates as data are integrated from different search engines. We developed a statistically coherent method for integrative analysis, termed MSblender. MSblender converts raw search scores from search engines into a probability score for every possible PSM and properly accounts for the correlation between search scores. The method reliably estimates false discovery rates and identifies more PSMs than any single search engine at the same false discovery rate. Increased identifications increment spectral counts for most proteins and allow quantification of proteins that would not have been quantified by individual search engines. We also demonstrate that enhanced quantification contributes to improve sensitivity in differential expression analyses. PMID:21488652

  18. Sand-shale ratio and sandy reservoir properties estimation from seismic attributes: An integrated study

    SciTech Connect

    Lefeuvre, F.E.; Wrolstad, K.H.; Zou, Ke Shan

    1995-12-31

    Total and Unocal estimated sand-shale ratios in gas reservoirs from the upper Tertiary clastics of Myanmar. They separately used deterministic pre-stack and statistical post-stack seismic attribute analysis calibrated at two wells to objectively extrapolate the lithologies and reservoir properties several kilometers away from the wells. The two approaches were then integrated and lead to a unique distribution of the sands and shales in the reservoir which fit in the known regional geological model. For the sands, the fluid distributions (gas and brine) were also estimated as well as the porosity, water saturation, thickness and clay content of the sands. This was made possible by using precise elastic modeling based on the Biot-Gassmann equation in order to integrate the effects of reservoir properties on seismic signatures.

  19. Safeguard By Design Lessons Learned from DOE Experience Integrating Safety into Design

    SciTech Connect

    Hockert, John; Burbank, Roberta L.

    2010-04-13

    This paper identifies the lessons to be learned for the institutionalization of Safeguards by Design (SBD) from the Department of Energy (DOE) experience developing and implementing DOE-STD-1189-2008, Integration of Safety into the Design Process. The experience is valuable because of the similarity of the challenges of integrating safety and safeguards into the design process. The paper reviews the content and development of DOE-STD-1189-2008 from its initial concept in January 2006 to its issuance in March 2008. Lessons learned are identified in the areas of the development and structure of requirements for the SBD process; the target audience for SBD requirements and guidance, the need for a graded approach to SBD, and a possible strategy for development and implementation of SBD within DOE.

  20. Allostasis and the human brain: Integrating models of stress from the social and life sciences

    PubMed Central

    Ganzel, Barbara L.; Morris, Pamela A.; Wethington, Elaine

    2009-01-01

    We draw on the theory of allostasis to develop an integrative model of the current stress process that highlights the brain as a dynamically adapting interface between the changing environment and the biological self. We review evidence that the core emotional regions of the brain constitute the primary mediator of the well-established association between stress and health, as well as the neural focus of “wear and tear” due to ongoing adaptation. This mediation, in turn, allows us to model the interplay over time between context, current stressor exposure, internal regulation of bodily processes, and health outcomes. We illustrate how this approach facilitates the integration of current findings in human neuroscience and genetics with key constructs from stress models from the social and life sciences, with implications for future research and the design of interventions targeting individuals at risk. PMID:20063966

  1. Integrated production of fuel gas and oxygenated organic compounds from synthesis gas

    DOEpatents

    Moore, Robert B.; Hegarty, William P.; Studer, David W.; Tirados, Edward J.

    1995-01-01

    An oxygenated organic liquid product and a fuel gas are produced from a portion of synthesis gas comprising hydrogen, carbon monoxide, carbon dioxide, and sulfur-containing compounds in a integrated feed treatment and catalytic reaction system. To prevent catalyst poisoning, the sulfur-containing compounds in the reactor feed are absorbed in a liquid comprising the reactor product, and the resulting sulfur-containing liquid is regenerated by stripping with untreated synthesis gas from the reactor. Stripping offgas is combined with the remaining synthesis gas to provide a fuel gas product. A portion of the regenerated liquid is used as makeup to the absorber and the remainder is withdrawn as a liquid product. The method is particularly useful for integration with a combined cycle coal gasification system utilizing a gas turbine for electric power generation.

  2. An Integrated, Low Temperature Process to Capture and Sequester Carbon Dioxide from Industrial Emissions

    NASA Astrophysics Data System (ADS)

    Wendlandt, R. F.; Foremski, J. J.

    2013-12-01

    Laboratory experiments show that it is possible to integrate (1) the chemistry of serpentine dissolution, (2) capture of CO2 gas from the combustion of natural gas and coal-fired power plants using aqueous amine-based solvents, (3) long-term CO2 sequestration via solid phase carbonate precipitation, and (4) capture solvent regeneration with acid recycling in a single, continuous process. In our process, magnesium is released from serpentine at 300°C via heat treatment with ammonium sulfate salts or at temperatures as low as 50°C via reaction with sulfuric acid. We have also demonstrated that various solid carbonate phases can be precipitated directly from aqueous amine-based (NH3, MEA, DMEA) CO2 capture solvent solutions at room temperature. Direct precipitation from the capture solvent enables regenerating CO2 capture solvent without the need for heat and without the need to compress the CO2 off gas. We propose that known low-temperature electrochemical methods can be integrated with this process to regenerate the aqueous amine capture solvent and recycle acid for dissolution of magnesium-bearing mineral feedstocks and magnesium release. Although the direct precipitation of magnesite at ambient conditions remains elusive, experimental results demonstrate that at temperatures ranging from 20°C to 60°C, either nesquehonite Mg(HCO3)(OH)●2H2O or a double salt with the formula [NH4]2Mg(CO3)2●4H2O or an amorphous magnesium carbonate precipitate directly from the capture solvent. These phases are less desirable for CO2 sequestration than magnesite because they potentially remove constituents (water, ammonia) from the reaction system, reducing the overall efficiency of the sequestration process. Accordingly, the integrated process can be accomplished with minimal energy consumption and loss of CO2 capture and acid solvents, and a net generation of 1 to 4 moles of H2O/6 moles of CO2 sequestered (depending on the solid carbonate precipitate and amount of produced H2

  3. An integrating current transformer for fast extraction from the HIRFL-CSR main ring

    NASA Astrophysics Data System (ADS)

    Wu, Jun-Xia; Zheng, Jian-Hua; Zhao, Tie-Cheng; Mao, Rui-Shi; Yin, Yan; Yuan, You-Jin; Yang, Jian-Cheng

    2010-01-01

    For any experiment that uses the beam of an accelerator, monitoring the beam intensity is always an important concern. It is particularly useful if one can continuously measure the beam current without disturbing the beam. We report here on test experiments for an Integrating Current Transformer (ICT) used to measure fast extraction beams from the HIRFL-CSR main ring (CSRm). The laboratory tests and beam intensity measurement results are presented in this paper. The influence of the kicker noise is also analyzed.

  4. The new integrals in the complex plane resulting from the coherent state formalism

    SciTech Connect

    Popov, Dušan E-mail: nicolina.pop@et.upt.ro; Pop, Nicolina E-mail: nicolina.pop@et.upt.ro; Şimon, Simona

    2013-11-13

    From the geometric point of view, it exists a one-to-one correspondence between the coherent states (CSs) | z, λ > and the points in the complex plane z. Consequently, the eigenvalues of the quantum operators will be numbers in the complex plane. In the paper we have deduced some new useful integrals in the complex plane - by using the expression of the Husimi's function for some oscillators: the harmonic and the pseudoharmonic one.

  5. Protecting integrated circuits from excessive charge accumulation during plasma cleaning of multichip modules

    SciTech Connect

    Rodenbeck, Christopher T; Girardi, Michael

    2015-04-21

    Internal nodes of a constituent integrated circuit (IC) package of a multichip module (MCM) are protected from excessive charge during plasma cleaning of the MCM. The protected nodes are coupled to an internal common node of the IC package by respectively associated discharge paths. The common node is connected to a bond pad of the IC package. During MCM assembly, and before plasma cleaning, this bond pad receives a wire bond to a ground bond pad on the MCM substrate.

  6. A case for integrity: gains from including more than animal welfare in animal ethics committee deliberations.

    PubMed

    Röcklinsberg, H; Gamborg, C; Gjerris, M

    2014-01-01

    From January 2013, a new EU Directive 63/2010/EU requires that research using animals must undergo a harm-benefit analysis, which takes ethical considerations into account (Art. 38 (2) d) - a so-called 'project authorization' (Art. 36). A competent authority in each member state has to ensure that no project is carried out without such a project validation process, but often delegates the actual assessment to an animal ethics committee (AEC) or its equivalent. The core task of the AEC is to formulate a justifiable balance between the animals' suffering caused by research and the potential human benefit. AECs traditionally focus on animal welfare issues, but according to the new directive other public concerns must also be taken into account. Taking the new EU Directive as a point of departure, the central aim of this paper is to discuss the evaluation process in relation to animal welfare and animal ethics through the concept of animal integrity. A further aim is to elaborate on possible improvements to project evaluation by considering animal integrity. We argue that concepts like animal integrity are often left out of project authorization processes within AECs, because animal ethics is often interpreted narrowly to include only certain aspects of animal welfare. Firstly, we describe the task of an AEC and discuss what has typically been regarded as ethically relevant in the assessment process. Secondly, we categorize four notions of integrity found in the literature to show the complexity of the concept and furthermore to indicate its strengths. Thirdly, we discuss how certain interpretations of integrity can be included in AEC assessments to encapsulate wider ethical concerns and, perhaps even increase the democratic legitimacy of AECs. PMID:24367033

  7. Integrating the results of user research into medical device development: insights from a case study

    PubMed Central

    2012-01-01

    Background It is well established that considering users is an important aspect of medical device development. However it is also well established that there are numerous barriers to successfully conducting user research and integrating the results into product development. It is not sufficient to simply conduct user research, it must also be effectively integrated into product development. Methods A case study of the development of a new medical imaging device was conducted to examine in detail how users were involved in a medical device development project. Two user research studies were conducted: a requirements elicitation interview study and an early prototype evaluation using contextual inquiry. A descriptive in situ approach was taken to investigate how these studies contributed to the product development process and how the results of this work influenced the development of the technology. Data was collected qualitatively through interviews with the development team, participant observation at development meetings and document analysis. The focus was on investigating the barriers that exist to prevent user data from being integrated into product development. Results A number of individual, organisational and system barriers were identified that functioned to prevent the results of the user research being fully integrated into development. The user and technological aspects of development were seen as separate work streams during development. The expectations of the developers were that user research would collect requirements for the appearance of the device, rather than challenge its fundamental concept. The manner that the user data was communicated to the development team was not effective in conveying the significance or breadth of the findings. Conclusion There are a range of informal and formal organisational processes that can affect the uptake of user data during medical device development. Adopting formal decision making processes may assist

  8. Automated and integrated system for high-throughput DNA genotyping directly from blood.

    PubMed

    Zhang, N; Tan, H; Yeung, E S

    1999-03-15

    An automated and integrated system for DNA typing directly from blood samples has been developed. The multiplexed eight-array system is based on capillary microfluidics and capillary array electrophoresis. Three short-tandem-repeat loci, vWA, THO1, and TPOX, are coamplified simultaneously in a fused-silica capillary by a hot-air thermocycler. Blood is directly used as the sample for polymerase chain reaction (PCR) without any pretreatment. Modifications of standard protocols are necessary for direct PCR from blood. A programmable syringe pump plus a set of multiplexed liquid nitrogen freeze/thaw switching valves are employed for liquid handling in the fluid distribution network. The system fully integrates sample loading, PCR, addition of an absolute standard, on-line injection of sample and standards, separation and detection. The genotypes from blood samples can be clearly identified in eight parallel channels when the electropherograms are compared with that of the standard allelic ladder by itself. Regeneration and cleaning of the entire system prior to subsequent runs are also integrated into the instrument. The instrumentation is compatible with future expansion to hundreds of capillaries to achieve even higher throughput. PMID:10093495

  9. Integrative Modeling of Macromolecular Assemblies from Low to Near-Atomic Resolution

    PubMed Central

    Xu, Xiaojun; Yan, Chunli; Wohlhueter, Robert; Ivanov, Ivaylo

    2015-01-01

    While conventional high-resolution techniques in structural biology are challenged by the size and flexibility of many biological assemblies, recent advances in low-resolution techniques such as cryo-electron microscopy (cryo-EM) and small angle X-ray scattering (SAXS) have opened up new avenues to define the structures of such assemblies. By systematically combining various sources of structural, biochemical and biophysical information, integrative modeling approaches aim to provide a unified structural description of such assemblies, starting from high-resolution structures of the individual components and integrating all available information from low-resolution experimental methods. In this review, we describe integrative modeling approaches, which use complementary data from either cryo-EM or SAXS. Specifically, we focus on the popular molecular dynamics flexible fitting (MDFF) method, which has been widely used for flexible fitting into cryo-EM maps. Second, we describe hybrid molecular dynamics, Rosetta Monte-Carlo and minimum ensemble search (MES) methods that can be used to incorporate SAXS into pseudoatomic structural models. We present concise descriptions of the two methods and their most popular alternatives, along with select illustrative applications to protein/nucleic acid assemblies involved in DNA replication and repair. PMID:26557958

  10. Structural elucidation of sorghum lignins from an integrated biorefinery process based on hydrothermal and alkaline treatments.

    PubMed

    Sun, Shao-Long; Wen, Jia-Long; Ma, Ming-Guo; Sun, Run-Cang

    2014-08-13

    An integrated process based on hydrothermal pretreatment (HTP) (i.e., 110-230 °C, 0.5-2.0 h) and alkaline post-treatment (2% NaOH at 90 °C for 2.0 h) has been performed for the production of xylooligosaccharide, lignin, and digestible substrate from sweet sorghum stems. The yield, purity, dissociation mechanisms, structural features, and structural transformations of alkali lignins obtained from the integrated process were investigated. It was found that the HTP process facilitated the subsequent alkaline delignification, releasing lignin with the highest yield (79.3%) and purity from the HTP residue obtained at 190 °C for 0.5 h. All of the results indicated that the cleavage of the β-O-4 linkages and degradation of β-β and β-5 linkages occurred under the harsh HTP conditions. Depolymerization and condensation reactions simultaneously occurred at higher temperatures (≥ 170 °C). Moreover, the thermostability of lignin was positively related to its molecular weight, but was also affected by the inherent structures, such as β-O-4 linkages and condensed units. These findings will enhance the understanding of structural transformations of the lignins during the integrated process and maximize the potential utilizations of the lignins in a current biorefinery process. PMID:25090032

  11. Integral Approaches to Determine Sub-Crustal Stress from Terrestrial Gravimetric Data

    NASA Astrophysics Data System (ADS)

    Eshagh, Mehdi

    2016-03-01

    The spherical harmonic expressions of the horizontal sub-crustal stress components induced by the mantle convection are convergent only to low degrees. In this paper, we use the method of stress (S) function with numerical differentiation and present a formula for determining the degree of convergence from the mean Moho depth. We found that for the global mean Moho depth, 23 km, this convergence degree is 622 and for Iran, 35 km, it is 372. Also, three methods are developed and applied for computing the sub-crustal stress, (1) direct integration with a spectral kernel limited up to the degree of convergence, (2) integral inversion with a kernel having closed-form formula without any frequency limit, and (3) solving an integral equation with limited spectral kernel to the convergence degree. The second method has no divergence problem and its kernel function is well behaving so that the system of equations from which the S function is determined is stable, and no regularisation is needed to solve it. It should be noted that for using this method the resolution of the recovery should be higher than 0.5° × 0.5°, otherwise the recovered S function and correspondingly the stress components will have smaller magnitude than those derived from the other two methods. Our numerical studies for stress recovery in Iran and its surrounding areas show that the methods, which use the limited spectral kernels to the convergence degree, deliver consistent results to that of the spherical harmonic expansion.

  12. Enriching libraries of high-aspect-ratio micro- or nanostructures by rapid, low-cost, benchtop nanofabrication.

    PubMed

    Kim, Philseok; Adorno-Martinez, Wilmer E; Khan, Mughees; Aizenberg, Joanna

    2012-02-01

    We provide a protocol for transforming the structure of an array of high-aspect-ratio (HAR) micro/nanostructures into various new geometries. Polymeric HAR arrays are replicated from a Bosch-etched silicon master pattern by soft lithography. By using various conditions, the original pattern is coated with metal, which acts as an electrode for the electrodeposition of conductive polymers, transforming the original structure into a wide range of user-defined new designs. These include scaled replicas with sub-100-nm-level control of feature sizes and complex 3D shapes such as tapered or bent columnar structures bearing hierarchical features. Gradients of patterns and shapes on a single substrate can also be produced. This benchtop fabrication protocol allows the production of customized libraries of arrays of closed-cell or isolated HAR micro/nanostructures at a very low cost within 1 week, when starting from a silicon master that otherwise would be very expensive and slow to produce using conventional fabrication techniques. PMID:22281867

  13. WABASH RIVER INTEGRATED METHANOL AND POWER PRODUCTION FROM CLEAN COAL TECHNOLGIES (IMPPCCT)

    SciTech Connect

    Albert C. Tsang

    2004-03-26

    The Wabash River Integrated Methanol and Power Production from Clean Coal Technologies (IMPPCCT) project is evaluating integrated electrical power generation and methanol production through clean coal technologies. The project is under the leadership of ConocoPhillips Company (COP), after it acquired Gasification Engineering Corporation (GEC) and the E-Gas gasification technology from Global Energy in July 2003. The project has completed Phase I, and is currently in Phase II of development. The two project phases include: (1) Feasibility study and conceptual design for an integrated demonstration facility at Global Energy's existing Wabash River Energy Limited (WREL) plant in West Terre Haute, Indiana, and for a fence-line commercial embodiment plants (CEP) operated at Dow Chemical or Dow Corning chemical plant locations; and (2) Research, development, and testing (RD&T) to define any technology gaps or critical design and integration issues. The Phase I of this project was supported by a multi-industry team consisting of Air Products and Chemicals, Inc., Dow Chemical Company, Dow Corning Corporation, Methanex Corporation, and Siemens Westinghouse Power Corporation, while Phase II is supported by Gas Technology Institute, TDA Research Inc., and Nucon International, Inc. The WREL integrated gasification combined cycle (IGCC) facility was designed, constructed, and operated under a project selected and co-funded under the Round IV of the United States Department of Energy's (DOE's) Clean Coal Technology Program. In this project, coal and/or other solid fuel feedstocks are gasified in an oxygen-blown, entrained-flow gasifier with continuous slag removal and a dry particulate removal system. The resulting product synthesis gas is used to fuel a combustion turbine generator whose exhaust is integrated with a heat recovery steam generator to drive a refurbished steam turbine generator. The gasifier uses technology initially developed by The Dow Chemical Company (the

  14. Wabash River Integrated Methanol and Power Production from Clean Coal Technologies (IMPPCCT)

    SciTech Connect

    Conocophillips

    2007-09-30

    The Wabash River Integrated Methanol and Power Production from Clean Coal Technologies (IMPPCCT) project was established to evaluate integrated electrical power generation and methanol production through clean coal technologies. The project was under the leadership of ConocoPhillips Company (COP), after it acquired Gasification Engineering Corporation (GEC) and the E-Gas gasification technology from Global Energy Inc. in July 2003. The project has completed both Phase 1 and Phase 2 of development. The two project phases include the following: (1) Feasibility study and conceptual design for an integrated demonstration facility at SG Solutions LLC (SGS), previously the Wabash River Energy Limited, Gasification Facility located in West Terre Haute, Indiana, and for a fence-line commercial embodiment plant (CEP) operated at the Dow Chemical Company or Dow Corning Corporation chemical plant locations. (2) Research, development, and testing (RD&T) to define any technology gaps or critical design and integration issues. Phase 1 of this project was supported by a multi-industry team consisting of Air Products and Chemicals, Inc., The Dow Chemical Company, Dow Corning Corporation, Methanex Corporation, and Siemens Westinghouse Power Corporation, while Phase 2 was supported by Gas Technology Institute, TDA Research Inc., and Nucon International, Inc. The SGS integrated gasification combined cycle (IGCC) facility was designed, constructed, and operated under a project selected and co-funded under the Round IV of the United States Department of Energy's (DOE's) Clean Coal Technology Program. In this project, coal and/or other carbonaceous fuel feedstocks are gasified in an oxygen-blown, entrained-flow gasifier with continuous slag removal and a dry particulate removal system. The resulting product synthesis gas (syngas) is used to fuel a combustion turbine generator whose exhaust is integrated with a heat recovery steam generator to drive a refurbished steam turbine generator

  15. Integrated Results from Analysis of the Rocknest Aeolian Deposit by the Curiosity Rover

    NASA Technical Reports Server (NTRS)

    Leshin, L. A.; Grotzinger, J. P.; Blake, D. F.; Edgett, K. S.; Gellert, R.; Mahaffy, P. R.; Malin, M. C.; Wiens, R. C.; Treiman, A. H.; Ming, D. W.; Eigenbrode, J.

    2013-01-01

    The Mars Science Laboratory Curiosity rover spent 45 sols (from sol 56-101) at an area called Rocknest (Fig. 1), characterizing local geology and ingesting its aeolian fines into the analytical instruments CheMin and SAM for mineralogical and chemical analysis. Many abstracts at this meeting present the contextual information and detailed data on these first solid samples analyzed in detail by Curiosity at Rocknest. Here, we present an integrated view of the results from Rocknest - the general agreement from discussions among the entire MSL Science Team.

  16. Fabrication of enzyme-degradable and size-controlled protein nanowires using single particle nano-fabrication technique

    NASA Astrophysics Data System (ADS)

    Omichi, Masaaki; Asano, Atsushi; Tsukuda, Satoshi; Takano, Katsuyoshi; Sugimoto, Masaki; Saeki, Akinori; Sakamaki, Daisuke; Onoda, Akira; Hayashi, Takashi; Seki, Shu

    2014-04-01

    Protein nanowires exhibiting specific biological activities hold promise for interacting with living cells and controlling and predicting biological responses such as apoptosis, endocytosis and cell adhesion. Here we report the result of the interaction of a single high-energy charged particle with protein molecules, giving size-controlled protein nanowires with an ultra-high aspect ratio of over 1,000. Degradation of the human serum albumin nanowires was examined using trypsin. The biotinylated human serum albumin nanowires bound avidin, demonstrating the high affinity of the nanowires. Human serum albumin-avidin hybrid nanowires were also fabricated from a solid state mixture and exhibited good mechanical strength in phosphate-buffered saline. The biotinylated human serum albumin nanowires can be transformed into nanowires exhibiting a biological function such as avidin-biotinyl interactions and peroxidase activity. The present technique is a versatile platform for functionalizing the surface of any protein molecule with an extremely large surface area.

  17. From the Phenomenology to the Mechanisms of Consciousness: Integrated Information Theory 3.0

    PubMed Central

    Tononi, Giulio

    2014-01-01

    This paper presents Integrated Information Theory (IIT) of consciousness 3.0, which incorporates several advances over previous formulations. IIT starts from phenomenological axioms: information says that each experience is specific – it is what it is by how it differs from alternative experiences; integration says that it is unified – irreducible to non-interdependent components; exclusion says that it has unique borders and a particular spatio-temporal grain. These axioms are formalized into postulates that prescribe how physical mechanisms, such as neurons or logic gates, must be configured to generate experience (phenomenology). The postulates are used to define intrinsic information as “differences that make a difference” within a system, and integrated information as information specified by a whole that cannot be reduced to that specified by its parts. By applying the postulates both at the level of individual mechanisms and at the level of systems of mechanisms, IIT arrives at an identity: an experience is a maximally irreducible conceptual structure (MICS, a constellation of concepts in qualia space), and the set of elements that generates it constitutes a complex. According to IIT, a MICS specifies the quality of an experience and integrated information ΦMax its quantity. From the theory follow several results, including: a system of mechanisms may condense into a major complex and non-overlapping minor complexes; the concepts that specify the quality of an experience are always about the complex itself and relate only indirectly to the external environment; anatomical connectivity influences complexes and associated MICS; a complex can generate a MICS even if its elements are inactive; simple systems can be minimally conscious; complicated systems can be unconscious; there can be true “zombies” – unconscious feed-forward systems that are functionally equivalent to conscious complexes. PMID:24811198

  18. From the phenomenology to the mechanisms of consciousness: Integrated Information Theory 3.0.

    PubMed

    Oizumi, Masafumi; Albantakis, Larissa; Tononi, Giulio

    2014-05-01

    This paper presents Integrated Information Theory (IIT) of consciousness 3.0, which incorporates several advances over previous formulations. IIT starts from phenomenological axioms: information says that each experience is specific--it is what it is by how it differs from alternative experiences; integration says that it is unified--irreducible to non-interdependent components; exclusion says that it has unique borders and a particular spatio-temporal grain. These axioms are formalized into postulates that prescribe how physical mechanisms, such as neurons or logic gates, must be configured to generate experience (phenomenology). The postulates are used to define intrinsic information as "differences that make a difference" within a system, and integrated information as information specified by a whole that cannot be reduced to that specified by its parts. By applying the postulates both at the level of individual mechanisms and at the level of systems of mechanisms, IIT arrives at an identity: an experience is a maximally irreducible conceptual structure (MICS, a constellation of concepts in qualia space), and the set of elements that generates it constitutes a complex. According to IIT, a MICS specifies the quality of an experience and integrated information ΦMax its quantity. From the theory follow several results, including: a system of mechanisms may condense into a major complex and non-overlapping minor complexes; the concepts that specify the quality of an experience are always about the complex itself and relate only indirectly to the external environment; anatomical connectivity influences complexes and associated MICS; a complex can generate a MICS even if its elements are inactive; simple systems can be minimally conscious; complicated systems can be unconscious; there can be true "zombies"--unconscious feed-forward systems that are functionally equivalent to conscious complexes. PMID:24811198

  19. Integrating family planning into postpartum care through modern quality improvement: experience from Afghanistan

    PubMed Central

    Tawfik, Youssef; Rahimzai, Mirwais; Ahmadzai, Malalah; Clark, Phyllis Annie; Kamgang, Evelyn

    2014-01-01

    To address low contraceptive use in Afghanistan, we supported 2 large public maternity hospitals and 3 private hospitals in Kabul to use modern quality improvement (QI) methods to integrate family planning into postpartum care. In 2012, QI teams comprising hospital staff applied root cause analysis to identify barriers to integrated postpartum family planning (PPFP) services and to develop solutions for how to integrate services. Changes made to service provision to address identified barriers included creating a private counseling space near the postpartum ward, providing PPFP counseling training and job aids to staff, and involving husbands and mothers-in-law in counseling in person or via mobile phones. After 10 months, the proportion of postpartum women who received family planning counseling before discharge in the 5 hospitals increased from 36% to 55%, and the proportion of women who received family planning counseling with their husbands rose from 18% to 90%. In addition, the proportion of postpartum women who agreed to use family planning and left the hospital with their preferred method increased from 12% to 95%. Follow-up telephone surveys with a random sample of women who had received PPFP services in the 2 public hospitals and a control group of postpartum women who had received routine hospital services found significant differences in the proportion of women with self-reported pregnancies: 3% vs. 15%, respectively, 6 months after discharge; 6% vs. 22% at 12 months; and 14% vs. 35% at 18 months (P < .001). Applying QI methods helped providers recognize and overcome barriers to integration of family planning and postpartum services by testing changes they deemed feasible. PMID:25276580

  20. High performance surface-enhanced Raman scattering substrates of Si-based Au film developed by focused ion beam nanofabrication

    PubMed Central

    2012-01-01

    A novel method with high flexibility and efficiency for developing SERS substrates is proposed by patterning nanostructures on Si substrates using focused ion beam direct writing (FIBDW) technology following with precise thermal evaporation of gold film on the substrate. The effect of SERS on the substrate was systematically investigated by optimizing the processing parameters and the gold film thickness. The results proved that small dwell time could improve the machining accuracy and obtain smaller nanogap. The Raman-enhanced performance of the substrate was investigated with 10−6mol/L Rhodamine 6 G solution. It was indicated that the elliptic nanostructures with 15-nm spacing on Si substrates, coated with approximately 15-nm thick gold film, have exhibited a high-enhanced performance, but dramatic performance degradation was found as the gold film thickness further increased, which most probably resulted from changes of the nanostructures’ morphology such as elliptical tip and spacing. To avoid the morphological changes effectively after depositing gold film, optimization design of the nanostructures for FIBDW on Si substrates was proposed. Besides, a similar phenomenon was found when the gold film was less than 15nm because there was little gold remaining on the substrate. The method proposed in this paper shows a great potential for the higher performance SERS substrates development, which can further reduce the spacing between hot spots. PMID:22804810

  1. High performance surface-enhanced Raman scattering substrates of Si-based Au film developed by focused ion beam nanofabrication.

    PubMed

    Gao, Tingting; Xu, Zongwei; Fang, Fengzhou; Gao, Wenlong; Zhang, Qing; Xu, Xiaoxuan

    2012-01-01

    A novel method with high flexibility and efficiency for developing SERS substrates is proposed by patterning nanostructures on Si substrates using focused ion beam direct writing (FIBDW) technology following with precise thermal evaporation of gold film on the substrate. The effect of SERS on the substrate was systematically investigated by optimizing the processing parameters and the gold film thickness. The results proved that small dwell time could improve the machining accuracy and obtain smaller nanogap. The Raman-enhanced performance of the substrate was investigated with 10-6mol/L Rhodamine 6 G solution. It was indicated that the elliptic nanostructures with 15-nm spacing on Si substrates, coated with approximately 15-nm thick gold film, have exhibited a high-enhanced performance, but dramatic performance degradation was found as the gold film thickness further increased, which most probably resulted from changes of the nanostructures' morphology such as elliptical tip and spacing. To avoid the morphological changes effectively after depositing gold film, optimization design of the nanostructures for FIBDW on Si substrates was proposed. Besides, a similar phenomenon was found when the gold film was less than 15nm because there was little gold remaining on the substrate. The method proposed in this paper shows a great potential for the higher performance SERS substrates development, which can further reduce the spacing between hot spots. PMID:22804810

  2. An economic benefit deriving from space activities: Integration between science institutions and industry

    NASA Astrophysics Data System (ADS)

    Monti, R.; D'Amore, M.; D'Angelo, L.

    1993-09-01

    A lively debate is taking place in Italy on the assessment of the economic benefits deriving from the national expenditure in space programmes. Specific studies have been recently committed by the Italian Space Agency on this subject. This paper aims at providing an original insight in this debate by focusing on the often underestimated effect that the development of space programmes has on the process of integration of university, research centres and industry. In fact, the economic analysis of the technology innovation evidences that the integration of research institutions and industry represents a key issue in the establishment of an effective national innovation system towards a higher industrial competitiveness. It is widely recognized that the initiation and promotion of the process of integration of industry and research institutions is primarily dependent on their cooperation within large public funded programmes in the field of high technology. Do space programmes show any peculiarity which make them especially suitable to generate an effective cooperation between industry and science institutions? The major goal of this paper will be to give an answer to this question through the analysis of the main characteristics of space programmes as far as the integration process is concerned. Space programmes will then be analysed identifying the critical aspects related to the process of research and technology development. Following, it will be demonstrated to which extent cooperation between industry and science institutions has been helpful in solving the identified critical aspects. The analysis will also address the organizational issues in order to identify the cooperation modes. Furthermore, an attempt will be made to assess the benefits deriving from the identified forms of cooperation in view of an increasing integration between industry and science institutions. The analysis will then be focused on the microgravity field; in fact, on the basis of the

  3. Nano-Fabrication Methods for Micro-Miniature Optical Thermometers Suited to High Temperatures and Harsh Environments

    NASA Astrophysics Data System (ADS)

    DePew, K. A.; Ma, C.; Schiffbauer, J. D.; Wang, J.; Dong, B.; Lally, E.; Wang, A.

    2012-12-01

    The Center for Photonics Technology (CPT) at Virginia Tech is engaged in cutting edge research of fiber optic sensing technologies. One current research area is the design of fiber optic temperature sensors for harsh environments. Fiber optic temperature sensing offers significant advantages over electronic sensing in terms of size and insensitivity to harsh environmental conditions and electromagnetic interference. In the field, fiber optic thermometers have been used in recent snow cover studies as well as fluvial temperature profiling projects. The extended capabilities of CPT optical sensors open further possibilities for application in additional geologic realms requiring high temperature sensing in corrosive environments. Significant strides have been made in developing single-crystal sapphire based fiber optic sensing elements for high temperature environments which are otherwise difficult to instrument. Utilization of strain insensitive designs and optical sapphire materials allow for thermometers capable of operation above 1500°C with reduced sensitivity to chemical corrosion and mechanical interference. Current efforts in fabrication techniques are reducing the footprint of temperature sensors below the millimeter scale while maintaining high resolution and operating range. The FEI Helios 600 NanoLab workstation at the Virginia Tech Institute for Critical Technologies and Applied Science has been employed, providing the capabilities necessary to reduce the footprint of sensing elements to the dimensions of standard optical communication fiber using a Ga+ focused ion beam (FIB). The capability of semi-distributed multi-point sensing can also be accomplished at this scale using similar FIB milling techniques. The fiber optic thermometer designs resulting from these methods are compact, lightweight, and able to provide remote sensing without need for electrical power at the measurement point. These traits make them an ideal sensing platform for laboratory

  4. The Solar Surface Differential Rotation from Disk-Integrated Chromospheric Fluxes

    NASA Astrophysics Data System (ADS)

    Donahue, Robert A.; Keil, Steven L.

    1995-06-01

    Disk-integrated solar chromospheric Ca ii K-line (3933.68 Å) fluxes have been measured almost daily at Sacramento Peak Observatory since 1977. Using observing windows selected to mimic seasonal windows for chromospheric measurements of lower Main-Sequence stars such as those observed by Mount Wilson Observatory's HK Project, we have measured the solar rotation from the modulation of the Ca ii K-line flux. We track the change of rotation period from the decline of cycle 21 through the maximum of cycle 22. This variation in rotation period is shown to behave as expected from the migration of active regions in latitude according to Maunder's ‘butterfly diagram’, including an abrupt change in rotation period at the transition from cycle 21 to cycle 22. These results indicate the successful detection of solar surface differential rotation from disk-integrated observations. We argue that the success of our study compared to previous investigations of the solar surface differential rotation from disk-integrated fluxes lies primarily with the choice of the length of the time-series window. Our selection of 200 days is shorter than in previous studies whose windows are typically on the order of one year. The 200-day window is long enough to permit an accurate determination of the rotation period, yet short enough to avoid complications arising from active region evolution. Thus, measurements of the variation of rotation period in lower Main-Sequence stars, especially those that appear to be correlated with long-term changes in chromospheric activity (i.e., cycles), are probably evidence for stellar surface differential rotation.

  5. Integrating Variable Renewable Energy in Electric Power Markets: Best Practices from International Experience

    SciTech Connect

    Cochran, J.; Bird, L.; Heeter, J.; Arent, D. A.

    2012-04-01

    Many countries -- reflecting very different geographies, markets, and power systems -- are successfully managing high levels of variable renewable energy on the electric grid, including that from wind and solar energy. This study documents the diverse approaches to effective integration of variable renewable energy among six countries -- Australia (South Australia), Denmark, Germany, Ireland, Spain, and the United States (Western region-Colorado and Texas)-- and summarizes policy best practices that energy ministers and other stakeholders can pursue to ensure that electricity markets and power systems can effectively coevolve with increasing penetrations of variable renewable energy. Each country has crafted its own combination of policies, market designs, and system operations to achieve the system reliability and flexibility needed to successfully integrate renewables. Notwithstanding this diversity, the approaches taken by the countries studied all coalesce around five strategic areas: lead public engagement, particularly for new transmission; coordinate and integrate planning; develop rules for market evolution that enable system flexibility; expand access to diverse resources and geographic footprint of operations; and improve system operations. The ability to maintain a broad ecosystem perspective, to organize and make available the wealth of experiences, and to ensure a clear path from analysis to enactment should be the primary focus going forward.

  6. Integration of Ethics across the Curriculum: From First Year through Senior Seminar†

    PubMed Central

    Gasparich, Gail E.; Wimmers, Larry

    2014-01-01

    The Fisher College of Science and Mathematics (FCSM) at Towson University (TU) has integrated authentic research experiences throughout the curriculum from first year STEM courses through advanced upper-level classes and independent research. Our observation is that training in both responsible conduct of research (RCR) and bioethics throughout the curriculum was an effective strategy to advance the cognitive and psychosocial development of the students. As students enter TU they generally lack the experience and tools to assess their own competence, to apply ethical debates, to investigate scientific topics from an ethical perspective, or to integrate ethics into final conclusions. Student behavior and development follow cognitive models such as described in the theories put forth by Piaget, Kohlberg, and Erikson, both for initial learning and for how concepts are understood and adopted. Three examples of this ethics training integration are described, including a cohort-based course for first year students in the STEM Residential Learning Community, a cohort-based course for community college students that are involved in an NIH-funded Bridges to the Baccalaureate program, and a senior seminar in Bioethics in the Molecular Biology, Biochemistry and Bioinformatics Program. All three focus on different aspects of RCR and bioethics training, providing opportunities for students to learn about the principles of effective decision-making, critical and analytical thinking, problem solving, and communication with increasing degrees of complexity as they move through the curriculum. PMID:25574282

  7. Reduced audiovisual integration in synesthesia--evidence from bimodal speech perception.

    PubMed

    Sinke, Christopher; Neufeld, Janina; Zedler, Markus; Emrich, Hinderk M; Bleich, Stefan; Münte, Thomas F; Szycik, Gregor R

    2014-03-01

    Recent research suggests synesthesia as a result of a hypersensitive multimodal binding mechanism. To address the question whether multimodal integration is altered in synesthetes in general, grapheme-colour and auditory-visual synesthetes were investigated using speech-related stimulation in two behavioural experiments. First, we used the McGurk illusion to test the strength and number of illusory perceptions in synesthesia. In a second step, we analysed the gain in speech perception coming from seen articulatory movements under acoustically noisy conditions. We used disyllabic nouns as stimulation and varied signal-to-noise ratio of the auditory stream presented concurrently to a matching video of the speaker. We hypothesized that if synesthesia is due to a general hyperbinding mechanism this group of subjects should be more susceptible to McGurk illusions and profit more from the visual information during audiovisual speech perception. The results indicate that there are differences between synesthetes and controls concerning multisensory integration--but in the opposite direction as hypothesized. Synesthetes showed a reduced number of illusions and had a reduced gain in comprehension by viewing matching articulatory movements in comparison to control subjects. Our results indicate that rather than having a hypersensitive binding mechanism, synesthetes show weaker integration of vision and audition. PMID:23279836

  8. Integration of Ethics across the Curriculum: From First Year through Senior Seminar.

    PubMed

    Gasparich, Gail E; Wimmers, Larry

    2014-12-01

    The Fisher College of Science and Mathematics (FCSM) at Towson University (TU) has integrated authentic research experiences throughout the curriculum from first year STEM courses through advanced upper-level classes and independent research. Our observation is that training in both responsible conduct of research (RCR) and bioethics throughout the curriculum was an effective strategy to advance the cognitive and psychosocial development of the students. As students enter TU they generally lack the experience and tools to assess their own competence, to apply ethical debates, to investigate scientific topics from an ethical perspective, or to integrate ethics into final conclusions. Student behavior and development follow cognitive models such as described in the theories put forth by Piaget, Kohlberg, and Erikson, both for initial learning and for how concepts are understood and adopted. Three examples of this ethics training integration are described, including a cohort-based course for first year students in the STEM Residential Learning Community, a cohort-based course for community college students that are involved in an NIH-funded Bridges to the Baccalaureate program, and a senior seminar in Bioethics in the Molecular Biology, Biochemistry and Bioinformatics Program. All three focus on different aspects of RCR and bioethics training, providing opportunities for students to learn about the principles of effective decision-making, critical and analytical thinking, problem solving, and communication with increasing degrees of complexity as they move through the curriculum. PMID:25574282

  9. MOSFET sensitivity dependence on integrated dose from high-energy photon beams.

    PubMed

    Tanyi, James A; Krafft, Shane P; Hagio, Tomoe; Fuss, Martin; Salter, Bill J

    2008-01-01

    The ability of a commercially available dual bias, dual MOSFET dosimetry system to measure therapeutic doses reproducibly throughout its vendor-defined dose-based lifetime has been evaluated by characterizing its sensitivity variation to integrated/cumulative doses from,high-energy (6 and 15 MV) photon radiotherapy beams. The variation of sensitivity as a function of total integrated dose was studied for three different dose-per-fraction levels; namely, 50, 200, and 1200 cGy/fraction. In standard sensitivity mode (i.e., measurements involving dose-per-fraction levels > or =100 cGy), the response of the MOSFET system to identical irradiations increased with integrated dose for both energies investigated. Dose measurement reproducibility for the low (i.e., 50 cGy) dose fractions was within 2.1% (if the system was calibrated before each in-phantom measurement) and 3.1% [if the system was calibrated prior to first use, with no intermediate calibration(s)]. Similarly, dose measurement reproducibility was between 2.2% and 6.6% for the conventional (i.e., 200 cGy) dose fractions and between 1.8% and 7.9% for escalated (i.e., 1200 cGy) dose fractions. The results of this study suggest that, due to the progressively increasing sensitivity resulting from the dual-MOSFET design, frequent calibrations are required to achieve measurement accuracy of < or =3% (within one standard deviation). PMID:18293559

  10. INTEGRAL/SPI Limits on Electron-Positron Annihilation Radiation from the Galactic Plane

    NASA Technical Reports Server (NTRS)

    Teegarden, B. J.; Watanabe, K.; Jean, P.; Knoedlseder, J.; Lonjou, V.; Roques, J. P.; Skinner, G. K.; vonBallmoos, P.; Weidenspointner, G.; Bazzano, A.

    2005-01-01

    The center of our Galaxy is a known strong source of electron-positron 511- keV annihilation radiation. Thus far, however, there have been no reliable detections of annihilation radiation outside of the central radian of our Galaxy. One of the primary objectives of the INTEGRAL (INTErnational Gamma-RAy Astrophysics Laboratory) mission, launched in Oct. 2002, is the detailed study of this radiation. The Spectrometer on INTEGRAL (SPI) is a high resolution coded-aperture gamma-ray telescope with an unprecedented combination of sensitivity, angular resolution and energy resolution. We report results from the first 10 months of observation. During this period a significant fraction of the observing time was spent in or near the Galactic Plane. No positive annihilation flux was detected outside of the central region (|l| greater than 40 degrees) of our Galaxy. In this paper we describe the observations and data analysis methods and give limits on the 511-keV flux.

  11. Distress from Motivational Dis-integration: When Fundamental Motives Are Too Weak or Too Strong.

    PubMed

    Cornwell, James F M; Franks, Becca; Higgins, E Tory

    2016-01-01

    Past research has shown that satisfying different kinds of fundamental motives contributes to well-being. More recently, advances in motivational theory have shown that z is also tied to the integration of different motives. In other words, well-being depends not only on maximizing effectiveness in satisfying specific motives, but also on ensuring that motives work together such that no individual motive is too weak or too strong. In this chapter, we review existing research to show that specific forms of psychological distress can be linked to specific types of motivational imbalance or dis-integration. Such disintegration can arise from either excessive weakness of a specific motive or the excessive strength and/or dominance of a specific motive, thereby inhibiting other motives. Possible neural correlates and avenues of intervention are discussed. PMID:26419241

  12. Lessons learned from the design and operation of the integrated topping cycle MHD generator

    SciTech Connect

    Pian, C.C.P.; Schmitt, E.W.

    1994-12-31

    Lessons learned from the design and operation of the Integrated Topping Cycle MHD generator are presented. This generator is part of a 50 MWt prototypic powertrain which recently completed proof-of-concept testing at the U.S. Department of Energy`s Component Development and Integration Facility. Duration testing was performed at conditions representative of future commercial MHD power plant operation in order to establish component lifetimes and to verify the design performance parameters. Over 500 cumulative hours of thermal and power tests were obtained with the generator hardware before the program was terminated. This paper summarizes the various lessons learned during the design and operation of the prototypic MHD power generator. Worthwhile features that should be adopted in future generator designs are discussed, as well as things one would do differently. Some issues remain unresolved at the conclusion of the test program; these are also summarized.

  13. An integrated nematic liquid crystal in-fiber modulator derivates from capillary optical fiber

    NASA Astrophysics Data System (ADS)

    Guo, Xiaohui; Yang, Xinghua; Li, Song; Liu, Zhihai; Hu, Minggang; Qu, Bin; Yuan, Libo

    2016-05-01

    A novel liquid crystal integrated modulation-depth-adjustable in-fiber modulator is proposed. The liquid crystal is encapsulated in a specially designed capillary optical fiber with tubular structure. The experimental results show that the liquid crystal under the electric field can influence the light intensity in the tubular core of the fiber. The light at 632.8 nm in the circular waveguide can be modulated by only 2.71×10-2 nL of the liquid crystals under electric field. The wide range of modulation-depth from 23% to 50% can be obtained by adjusting the strength of the external electric field. In addition, the modulator shows good stability and repeatability. This work has great potentials in integrated in-fiber optical devices such as tunable modulators, optical switches and electric field sensors.

  14. WABASH RIVER INTEGRATED METHANOL AND POWER PRODUCTION FROM CLEAN COAL TECHNOLOGIES (IMPPCCT)

    SciTech Connect

    Thomas Lynch

    2004-01-07

    The Wabash River Integrated Methanol and Power Production from Clean Coal Technologies (IMPPCCT) project is evaluating integrated electrical power generation and methanol production through clean coal technologies. The project is conducted by a multi-industry team lead previously by Gasification Engineering Corporation (GEC). The project is now under the leadership of ConocoPhillips Company (COP) after it acquired GEC and the E-Gas{trademark} gasification technology from Global Energy in July 2003. The Phase I of this project was supported by Air Products and Chemicals, Inc., Dow Chemical Company, Dow Corning Corporation, Methanex Corporation, and Siemens Westinghouse Power Corporation, while the Phase II is supported by Gas Technology Institute, TDA Research, Inc., and Nucon International, Inc. The two project phases planned for execution include: (1) Feasibility study and conceptual design for an integrated demonstration facility at Global Energy's existing Wabash River Energy Limited (WREL) plant in West Terre Haute, Indiana, and for a fence-line commercial embodiment plants (CEP) operated at Dow Chemical or Dow Corning chemical plant locations (2) Research, development, and testing (RD&T) to define any technology gaps or critical design and integration issues. The WREL facility was designed, constructed, and operated under a project selected and co-funded under the Round IV of the United States Department of Energy's (DOE's) Clean Coal Technology Program. In this project, coal and/or other solid fuel feedstocks are gasified in an oxygen-blown, entrained-flow gasifier with continuous slag removal and a dry particulate removal system. The resulting product synthesis gas is used to fuel a combustion turbine generator whose exhaust is integrated with a heat recovery steam generator to drive a refurbished steam turbine generator. The gasifier uses technology initially developed by The Dow Chemical Company (the Destec Gasification Process), and now acquired and

  15. WABASH RIVER INTEGRATED METHANOL AND POWER PRODUCTION FROM CLEAN COAL TECHNOLOGIES (IMPPCCT)

    SciTech Connect

    Gary Harmond; Albert Tsang

    2003-03-14

    The Wabash River Integrated Methanol and Power Production from Clean Coal Technologies (IMPPCCT) project is evaluating integrated electrical power generation and methanol production through clean coal technologies. The project is conducted by a multi-industry team lead by Gasification Engineering Corporation (GEC), a company of Global Energy Inc., and supported by Air Products and Chemicals, Inc., Dow Chemical Company, Dow Corning Corporation, Methanex Corporation, and Siemens Westinghouse Power Corporation. Three project phases are planned for execution over a three year period, including: (1) Feasibility study and conceptual design for an integrated demonstration facility, and for fence-line commercial embodiment plants (CEP) operated at Dow Chemical or Dow Corning chemical plant locations (2) Research, development, and testing to define any technology gaps or critical design and integration issues (3) Engineering design and financing plan to install an integrated commercial demonstration facility at the existing Wabash River Energy Limited (WREL) plant in West Terre Haute, Indiana. The WREL facility is a project selected and co-funded under the Round IV of the U.S. Department of Energy's (DOE's) Clean Coal Technology Program. In this project, coal and/or other solid fuel feedstocks are gasified in an oxygen-blown, entrained-flow gasifier with continuous slag removal and a dry particulate removal system. The resulting product synthesis gas is used to fuel a combustion turbine generator whose exhaust is integrated with a heat recovery steam generator to drive a refurbished steam turbine generator. The gasifier uses technology initially developed by The Dow Chemical Company (the Destec Gasification Process), and now offered commercially by Global Energy, Inc., as the E-GAS{trademark} technology. In a joint effort with the DOE, a Cooperative Agreement was awarded under the Early Entrance Coproduction Plant (EECP) solicitation. GEC and an Industrial Consortium are

  16. SAMPLE RESULTS FROM THE INTEGRATED SALT DISPOSITION PROGRAM MACROBATCH 5 TANK 21H QUALIFICATION SAMPLES

    SciTech Connect

    Peters, T.; Fink, S.

    2012-03-26

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 5 for the Integrated Salt Disposition Project (ISDP). This document reports partial results of the analyses of samples of Tank 21H. No issues with the projected Salt Batch 5 strategy are identified. Results of the analyses of the Tank 21H samples from this report in conjunction with the findings of the previous report, indicates that the material does not display any unusual characteristics.

  17. Task-level robot programming: Integral part of evolution from teleoperation to autonomy

    NASA Technical Reports Server (NTRS)

    Reynolds, James C.

    1987-01-01

    An explanation is presented of task-level robot programming and of how it differs from the usual interpretation of task planning for robotics. Most importantly, it is argued that the physical and mathematical basis of task-level robot programming provides inherently greater reliability than efforts to apply better known concepts from artificial intelligence (AI) to autonomous robotics. Finally, an architecture is presented that allows the integration of task-level robot programming within an evolutionary, redundant, and multi-modal framework that spans teleoperation to autonomy.

  18. Insights from a pilot program to integrate medical and social services.

    PubMed

    Meiners, Mark R; Mokler, Pamela M; Kasunic, Mary Lynn; Hawthornthwaite, Scott; Foster, Susan; Scheer, David; Maldonado, Anna Maria

    2014-01-01

    This study examines lessons learned from the design, implementation, and early results of an integrated managed care pilot program linking member benefits of a Medicare-Medicaid health care plan with community services and supports. The health plan's average monthly costs for members receiving an assessment and services declined by an economically meaningful, statistically significant amount in the postintervention period relative to the preintervention period compared with those who did not accept an assessment or services. The results along with the lesson learned from the pilot are viewed by the parties as supportive of further program development. PMID:24924659

  19. Characterizing chaotic dynamics from integrate-and-fire interspike intervals at the presence of noise

    NASA Astrophysics Data System (ADS)

    Mohammad, Yasir K.; Pavlova, Olga N.; Pavlov, Alexey N.

    2016-04-01

    We discuss the problem of quantifying chaotic dynamics at the input of the "integrate-and-fire" (IF) model from the output sequences of interspike intervals (ISIs) for the case when the fluctuating threshold level leads to the appearance of noise in ISI series. We propose a way to detect an ability of computing dynamical characteristics of the input dynamics and the level of noise in the output point processes. The proposed approach is based on the dependence of the largest Lyapunov exponent from the maximal orientation error used at the estimation of the averaged rate of divergence of nearby phase trajectories.

  20. Advancements in integrating DSM and distributed generation and storage into T&D planning: Proceedings from the Third Annual Workshop

    SciTech Connect

    Not Available

    1994-09-01

    This third in a series of annual EPRI workshops focused on integrating demand-side management and distributed generation an into transmission and distribution planning. The workshop included utility case studies on integrated planning, results from utility pilot projects, analytical developments, and cross-departmental planning and implementation. In addition, the workshop featured information on advancements in area-specific planning and costing methods along with EPRI products that support utility integrated planning efforts.

  1. From 200 BC to 2015 AD: an integration of robotic surgery and Ayurveda/Yoga

    PubMed Central

    Pillai, Geethakrishnan Gopalakrishna

    2016-01-01

    Background Among the traditional systems of medicine practiced all over the world, Ayurveda and Yoga has a documented history dating back to beyond 200 BC. Robotic and video assisted thoracic surgery (VATS) is an invention of the 21st century. We aim to quantify the effects of integration of Ayurveda and Yoga on patients undergoing minimally invasive robotic and VATS. Methods Four hundred and fifty-four patients undergoing VATS and robotic thoracic surgery were introduced to a pre and postoperative protocol of Yoga therapy, mediation and oil massages. Yoga exercises included Pranayam, Anulom Vilom, and Oil Massages included Urotarpan. Preoperative and postoperative respiratory functions were recorded. Patient satisfaction questionnaire were noted. Statistical comparison was made to control group undergoing minimally invasive thoracic surgery without integrative medicine. Only one patient refused to undergo Ayurveda therapy and was deleted from the group. Results Acceptability was high among all patients. Preoperative training led to implementation as early as 6 hours post surgery. Pulmonary function test showed significant improvement. All patients suggested an improvement in satisfaction score. Pain score were less in study patients. Quicker mobilization led to early discharge and drain removal. Chronic pain was prevented in patients having oil massages over the healed wound sites. Conclusions Integration of Ayurveda, Yoga and minimally invasive robotic and VATS is acceptable to Indian patients and gives better clinical results and higher patient satisfaction. PMID:26941975

  2. Knowledge Integration to Make Decisions About Complex Systems: Sustainability of Energy Production from Agriculture

    ScienceCinema

    Danuso, Francesco [University of Udine, Italy

    2010-01-08

    A major bottleneck for improving the governance of complex systems, rely on our ability to integrate different forms of knowledge into a decision support system (DSS). Preliminary aspects are the classification of different types of knowledge (a priori or general, a posteriori or specific, with uncertainty, numerical, textual, algorithmic, complete/incomplete, etc.), the definition of ontologies for knowledge management and the availability of proper tools like continuous simulation models, event driven models, statistical approaches, computational methods (neural networks, evolutionary optimization, rule based systems etc.) and procedure for textual documentation. Following these views at University of Udine, a computer language (SEMoLa, Simple, Easy Modelling Language) for knowledge integration has been developed.  SEMoLa can handle models, data, metadata and textual knowledge; it implements and extends the system dynamics ontology (Forrester, 1968; Jørgensen, 1994) in which systems are modelled by the concepts of material, group, state, rate, parameter, internal and external events and driving variables. As an example, a SEMoLa model to improve management and sustainability (economical, energetic, environmental) of the agricultural farms is presented. The model (X-Farm) simulates a farm in which cereal and forage yield, oil seeds, milk, calves and wastes can be sold or reused. X-Farm is composed by integrated modules describing fields (crop and soil), feeds and materials storage, machinery management, manpower  management, animal husbandry, economic and energetic balances, seed oil extraction, manure and wastes management, biogas production from animal wastes and biomasses.

  3. Generation of Integration-free Induced Neural Stem Cells from Mouse Fibroblasts.

    PubMed

    Kim, Sung Min; Kim, Jong-Wan; Kwak, Tae Hwan; Park, Sang Woong; Kim, Kee-Pyo; Park, Hyunji; Lim, Kyung Tae; Kang, Kyuree; Kim, Jonghun; Yang, Ji Hun; Han, Heonjong; Lee, Insuk; Hyun, Jung Keun; Bae, Young Min; Schöler, Hans R; Lee, Hoon Taek; Han, Dong Wook

    2016-07-01

    The viral vector-mediated overexpression of the defined transcription factors, Brn4/Pou3f4, Sox2, Klf4, and c-Myc (BSKM), could induce the direct conversion of somatic fibroblasts into induced neural stem cells (iNSCs). However, viral vectors may be randomly integrated into the host genome thereby increasing the risk for undesired genotoxicity, mutagenesis, and tumor formation. Here we describe the generation of integration-free iNSCs from mouse fibroblasts by non-viral episomal vectors containing BSKM. The episomal vector-derived iNSCs (e-iNSCs) closely resemble control NSCs, and iNSCs generated by retrovirus (r-iNSCs) in morphology, gene expression profile, epigenetic status, and self-renewal capacity. The e-iNSCs are functionally mature, as they could differentiate into all the neuronal cell types both in vitro and in vivo Our study provides a novel concept for generating functional iNSCs using a non-viral, non-integrating, plasmid-based system that could facilitate their biomedical applicability. PMID:27189941

  4. Synthetic dimensions in integrated photonics: From optical isolation to four-dimensional quantum Hall physics

    NASA Astrophysics Data System (ADS)

    Ozawa, Tomoki; Price, Hannah M.; Goldman, Nathan; Zilberberg, Oded; Carusotto, Iacopo

    2016-04-01

    Recent technological advances in integrated photonics have spurred on the study of topological phenomena in engineered bosonic systems. Indeed, the controllability of silicon ring-resonator arrays has opened up new perspectives for building lattices for photons with topologically nontrivial bands and integrating them into photonic devices for practical applications. Here, we push these developments even further by exploiting the different modes of a silicon ring resonator as an extra dimension for photons. Tunneling along this synthetic dimension is implemented via an external time-dependent modulation that allows for the generation of engineered gauge fields. We show how this approach can be used to generate a variety of exciting topological phenomena in integrated photonics, ranging from a topologically-robust optical isolator in a spatially one-dimensional (1D) ring-resonator chain to a driven-dissipative analog of the 4D quantum Hall effect in a spatially 3D resonator lattice. Our proposal paves the way towards the use of topological effects in the design of novel photonic lattices supporting many frequency channels and displaying higher connectivities.

  5. Natural resources benefit from cooperatively conducted NRDAs that integrate remediation and restoration

    SciTech Connect

    Robilliard, G.; Campbell, T.; Luthi, R.; Monarch, J.

    1994-12-31

    As a practical matter, the goal of the natural resource damage assessment (NRDA) process is becoming restoration to ``without incident`` conditions, of the injured natural resources and the services they provided. Some trustees are advocating that this goal be identified at the beginning of the traditional ``Superfund`` process instead of after remediation is complete. The trustees and enlightened PRPs recognize that to do otherwise is to incur significant transaction costs, lost opportunity costs, ongoing lost use (and, in some cases, passive or non-use) damages, and ill will between the parties. Damages assessed in the litigation mode may be greater than would be paid if a cooperative process that integrates restoration into the remediation or removal actions is pursued. The cooperative, integrated approach has several advantages including: emphasis on natural resource products rather than litigation processes; environmental benefit from the restoration/remediation actions; reduction in transaction costs; reduction in legal and financial uncertainty; results in resource benefits earlier than traditional Superfund process would; fosters sharing of technical information and expertise; and reduces ill will between PRPs and the trustees and the public. The cooperative, integrated process requires several key ingredients with the most important ones being professional trust and cooperation among the PRPS, federal and state trustees and agreement on the goals, performance standards and procedure for implementing the process.

  6. Integrating community based disaster risk reduction and climate change adaptation: examples from the Pacific

    NASA Astrophysics Data System (ADS)

    Gero, A.; Méheux, K.; Dominey-Howes, D.

    2011-01-01

    It is acknowledged by academics and development practitioners alike that many common strategies addressing community based disaster risk reduction and climate change adaptation duplicate each other. Thus, there is a strong push to integrate the two fields to enhance aid effectiveness and reduce confusion for communities. Examples of community based disaster risk reduction (DRR) and climate change adaptation (CCA) projects are presented to highlight some of the ways these issues are tackled in the Pacific. Various approaches are employed but all aim to reduce the vulnerability and enhance the resilience of local communities to the impacts of climate change and disasters. By focusing on three case studies, elements of best practice are drawn out to illustrate how DRR and CCA can be integrated for enhanced aid effectiveness, and also look at ways in which these two often overlapping fields can be better coordinated in ongoing and future projects. Projects that address vulnerability holistically, and target the overall needs and capacity of the community are found to be effective in enhancing the resilience of communities. By strategically developing a multi-stakeholder and multi-sector approach, community projects are likely to encapsulate a range of experience and skills that will benefit the community. Furthermore, by incorporating local knowledge, communities are far more likely to be engaged and actively participate in the project. From selected case studies, commonly occurring best practice methods to integrate DRR and CCA are identified and discussed and recommendations on how to overcome the common challenges also presented.

  7. Results from the first two years of the INTEGRAL Spiral Arms Monitoring Program

    NASA Astrophysics Data System (ADS)

    Bodaghee, Arash; Spetzer, Keri

    2014-08-01

    We describe the scientific objectives and main highlights from the first 2 years of an INTEGRAL "Key Program" consisting of high-cadence monitoring of the inner spiral arms of the Galaxy paired with ToO observations of new transients with XMM-Newton and Swift. The INTEGRAL Spiral Arms (ISA) program (25.6 ks per spacecraft revolution during visibility periods, for a total of 1.2 Ms per year since 2012) complements the successful Galactic Bulge (GB) program by extending the monitored region of the Galaxy to the Inner Perseus/Norma Arm tangents on one side of the GB, and the Scutum/Sagittarius Arms on the other. These fields feature a high density of obscured high-mass X-ray binaries (HMXBs), including Supergiant Fast X-ray Transients (SFXTs), as well as other hard X-ray emitting sources (e.g. microquasars, low-mass X-ray binaries, and magnetars) that INTEGRAL is well-suited to finding thanks to its large field of view and angular resolution at high energies even in crowded regions of the sky. Mosaic images and source light curves in 2 energy bands for ISGRI and JEM-X are being provided to the community permitting rapid dissemination of results (http://isa.gcsu.edu) which enable prompt follow-up of interesting events. The ISA project represents the cornerstone of our ongoing study of transient and variable hard X-ray populations in the Milky Way.

  8. An integrated approach to energy recovery from biomass and waste: Anaerobic digestion-gasification-water treatment.

    PubMed

    Milani, M; Montorsi, L; Stefani, M

    2014-07-01

    The article investigates the performance of an integrated system for the energy recovery from biomass and waste based on anaerobic digestion, gasification and water treatment. In the proposed system, the organic fraction of waste of the digestible biomass is fed into an anaerobic digester, while a part of the combustible fraction of the municipal solid waste is gasified. Thus, the obtained biogas and syngas are used as a fuel for running a cogeneration system based on an internal combustion engine to produce electric and thermal power. The waste water produced by the integrated plant is recovered by means of both forward and inverse osmosis. The different processes, as well as the main components of the system, are modelled by means of a lumped and distributed parameter approach and the main outputs of the integrated plant such as the electric and thermal power and the amount of purified water are calculated. Finally, the implementation of the proposed system is evaluated for urban areas with a different number of inhabitants and the relating performance is estimated in terms of the main outputs of the system. PMID:24946772

  9. Iterative solution of dense linear systems arising from the electrostatic integral equation in MEG.

    PubMed

    Rahol, Jussi; Tissari, Satu

    2002-03-21

    We study the iterative solution of dense linear systems that arise from boundary element discretizations of the electrostatic integral equation in magnetoencephalography (MEG). We show that modern iterative methods can be used to decrease the total computation time by avoiding the time-consuming computation of the LU decomposition of the coefficient matrix. More importantly, the modern iterative methods make it possible to avoid the explicit formation of the coefficient matrix which is needed when a large number of unknowns are used. To study the convergence of iterative solvers we examine the eigenvalue distributions of the coefficient matrices. For the sphere we show how the eigenvalues of the integral operator are approximated by the eigenvalues of the coefficient matrix when the collocation and Galerkin methods are used as discretization methods. The collocation method approximates the eigenvalues of the integral operator directly. The Galerkin method produces a coefficient matrix that needs to be preconditioned in order to maintain optimal convergence speed. With the ILU(0) preconditioner iterative methods converge fast and independent of the number of discretization points for both the collocation and Galerkin approaches. The preconditioner has no significant effect on the total computational time. PMID:11936181

  10. CPICOR{trademark}: Clean power from integrated coal-ore reduction

    SciTech Connect

    Wintrell, R.; Miller, R.N.; Harbison, E.J.; LeFevre, M.O.; England, K.S.

    1997-12-31

    The US steel industry, in order to maintain its basic iron production, is thus moving to lower coke requirements and to the cokeless or direct production of iron. The US Department of Energy (DOE), in its Clean Coal Technology programs, has encouraged the move to new coal-based technology. The steel industry, in its search for alternative direct iron processes, has been limited to a single process, COREX{reg_sign}. The COREX{reg_sign} process, though offering commercial and environmental acceptance, produces a copious volume of offgas which must be effectively utilized to ensure an economical process. This volume, which normally exceeds the internal needs of a single steel company, offers a highly acceptable fuel for power generation. The utility companies seeking to offset future natural gas cost increases are interested in this clean fuel. The COREX{reg_sign} smelting process, when integrated with a combined cycle power generation facility (CCPG) and a cryogenic air separation unit (ASU), is an outstanding example of a new generation of environmentally compatible and highly energy efficient Clean Coal Technologies. This combination of highly integrated electric power and hot metal coproduction, has been designated CPICOR{trademark}, Clean Power from Integrated Coal/Ore Reduction.

  11. Age and metallicity of star clusters in the Small Magellanic Cloud from integrated spectroscopy

    NASA Astrophysics Data System (ADS)

    Dias, Bruno; Coelho, Paula; Kerber, Leandro; Barbuy, Beatriz; Idiart, Thais

    2010-04-01

    Analysis of integrated spectra of star clusters in the Magellanic Clouds can bring important information for studies on the chemical evolution of the Clouds. The aim of the present work is to derive ages and metallicities from integrated spectra of 15 star clusters in the Small Magellanic Cloud (SMC), some of them not studied so far. Making use of a full spectrum fitting technique, we compared the integrated spectra of the sample clusters to three different sets of single stellar population models available in the literature. We derived ages and metallicities for the sample clusters employing the codes STARLIGHT and ULySS. Out of the 15 clusters in our sample, 9 are old/intermediate age clusters and 6 are young clusters. We point out the results for the newly identified as old/intermediate age clusters HW1, NGC 152, Lindsay 3 and 11. We also confirm old ages for NGC 361, NGC 419 and Kron 3, and the oldest well-known SMC cluster NGC 121.

  12. Iterative solution of dense linear systems arising from the electrostatic integral equation in MEG

    NASA Astrophysics Data System (ADS)

    Rahola, Jussi; Tissari, Satu

    2002-03-01

    We study the iterative solution of dense linear systems that arise from boundary element discretizations of the electrostatic integral equation in magnetoencephalography (MEG). We show that modern iterative methods can be used to decrease the total computation time by avoiding the time-consuming computation of the LU decomposition of the coefficient matrix. More importantly, the modern iterative methods make it possible to avoid the explicit formation of the coefficient matrix which is needed when a large number of unknowns are used. To study the convergence of iterative solvers we examine the eigenvalue distributions of the coefficient matrices. For the sphere we show how the eigenvalues of the integral operator are approximated by the eigenvalues of the coefficient matrix when the collocation and Galerkin methods are used as discretization methods. The collocation method approximates the eigenvalues of the integral operator directly. The Galerkin method produces a coefficient matrix that needs to be preconditioned in order to maintain optimal convergence speed. With the ILU(0) preconditioner iterative methods converge fast and independent of the number of discretization points for both the collocation and Galerkin approaches. The preconditioner has no significant effect on the total computational time.

  13. Knowledge Integration to Make Decisions About Complex Systems: Sustainability of Energy Production from Agriculture

    SciTech Connect

    Danuso, Francesco

    2008-06-18

    A major bottleneck for improving the governance of complex systems, rely on our ability to integrate different forms of knowledge into a decision support system (DSS). Preliminary aspects are the classification of different types of knowledge (a priori or general, a posteriori or specific, with uncertainty, numerical, textual, algorithmic, complete/incomplete, etc.), the definition of ontologies for knowledge management and the availability of proper tools like continuous simulation models, event driven models, statistical approaches, computational methods (neural networks, evolutionary optimization, rule based systems etc.) and procedure for textual documentation. Following these views at University of Udine, a computer language (SEMoLa, Simple, Easy Modelling Language) for knowledge integration has been developed. SEMoLa can handle models, data, metadata and textual knowledge; it implements and extends the system dynamics ontology (Forrester, 1968; Joergensen, 1994) in which systems are modeled by the concepts of material, group, state, rate, parameter, internal and external events and driving variables. As an example, a SEMoLa model to improve management and sustainability (economical, energetic, environmental) of the agricultural farms is presented. The model (X-Farm) simulates a farm in which cereal and forage yield, oil seeds, milk, calves and wastes can be sold or reused. X-Farm is composed by integrated modules describing fields (crop and soil), feeds and materials storage, machinery management, manpower management, animal husbandry, economic and energetic balances, seed oil extraction, manure and wastes management, biogas production from animal wastes and biomasses.

  14. Knowledge Integration to Make Decisions About Complex Systems: Sustainability of Energy Production from Agriculture

    SciTech Connect

    Danuso, Francesco

    2008-06-18

    A major bottleneck for improving the governance of complex systems, rely on our ability to integrate different forms of knowledge into a decision support system (DSS). Preliminary aspects are the classification of different types of knowledge (a priori or general, a posteriori or specific, with uncertainty, numerical, textual, algorithmic, complete/incomplete, etc.), the definition of ontologies for knowledge management and the availability of proper tools like continuous simulation models, event driven models, statistical approaches, computational methods (neural networks, evolutionary optimization, rule based systems etc.) and procedure for textual documentation. Following these views at University of Udine, a computer language (SEMoLa, Simple, Easy Modelling Language) for knowledge integration has been developed.  SEMoLa can handle models, data, metadata and textual knowledge; it implements and extends the system dynamics ontology (Forrester, 1968; Jørgensen, 1994) in which systems are modelled by the concepts of material, group, state, rate, parameter, internal and external events and driving variables. As an example, a SEMoLa model to improve management and sustainability (economical, energetic, environmental) of the agricultural farms is presented. The model (X-Farm) simulates a farm in which cereal and forage yield, oil seeds, milk, calves and wastes can be sold or reused. X-Farm is composed by integrated modules describing fields (crop and soil), feeds and materials storage, machinery management, manpower  management, animal husbandry, economic and energetic balances, seed oil extraction, manure and wastes management, biogas production from animal wastes and biomasses.

  15. DYNAMIC STABILITY OF THE SOLAR SYSTEM: STATISTICALLY INCONCLUSIVE RESULTS FROM ENSEMBLE INTEGRATIONS

    SciTech Connect

    Zeebe, Richard E.

    2015-01-01

    Due to the chaotic nature of the solar system, the question of its long-term stability can only be answered in a statistical sense, for instance, based on numerical ensemble integrations of nearby orbits. Destabilization of the inner planets, leading to close encounters and/or collisions can be initiated through a large increase in Mercury's eccentricity, with a currently assumed likelihood of ∼1%. However, little is known at present about the robustness of this number. Here I report ensemble integrations of the full equations of motion of the eight planets and Pluto over 5 Gyr, including contributions from general relativity. The results show that different numerical algorithms lead to statistically different results for the evolution of Mercury's eccentricity (e{sub M}). For instance, starting at present initial conditions (e{sub M}≃0.21), Mercury's maximum eccentricity achieved over 5 Gyr is, on average, significantly higher in symplectic ensemble integrations using heliocentric rather than Jacobi coordinates and stricter error control. In contrast, starting at a possible future configuration (e{sub M}≃0.53), Mercury's maximum eccentricity achieved over the subsequent 500 Myr is, on average, significantly lower using heliocentric rather than Jacobi coordinates. For example, the probability for e{sub M} to increase beyond 0.53 over 500 Myr is >90% (Jacobi) versus only 40%-55% (heliocentric). This poses a dilemma because the physical evolution of the real system—and its probabilistic behavior—cannot depend on the coordinate system or the numerical algorithm chosen to describe it. Some tests of the numerical algorithms suggest that symplectic integrators using heliocentric coordinates underestimate the odds for destabilization of Mercury's orbit at high initial e{sub M}.

  16. Research Integrity Practices from the Perspective of Early-Career Researchers.

    PubMed

    Krstić, Snežana B

    2015-10-01

    Unavailability of published data and studies focused on young researchers in Europe and research integrity issues reveals that clear understanding and stance on this subject within European area is lacking. Our study provides information on attitudes and experiences of European researchers at early career stages (doctoral and postdoctoral level), based on a limited sample of respondents (n = 27). The study provides both quantitative and qualitative results for the examined issues. The data suggest that awareness and interest of the younger researchers surveyed in research integrity issues is high, however, it is often based on self-initiatives, with many of the respondents not having adequate training or any possibility to obtain it. Our attitude survey conducted within the European Council of Doctoral Candidates and Junior Researchers indicates that only 22 % of respondents had an opportunity to obtain relevant training (significantly less than in a study conducted in the U.S.), and that only one third believed that institutions and supervisors regularly paid attention to it. Further, we noted certain differences between disciplines. The study also reveals that many younger researchers felt they faced problems due to the misconduct of their senior colleagues and the existing institutional culture. The results of the study indicate a need for better prevention mechanisms, training and raising awareness activities. Preferably, junior researchers should be given an active role in shaping the integrity culture. It should be noted that the presented results should be considered in the context of the limitations stemming from the small-scale survey. This paper encourages further research activities on research integrity practices to provide stronger evidence on the attitudes and experiences of young researchers in Europe and other parts of the world. PMID:25344843

  17. Dynamic Stability of the Solar System: Statistically Inconclusive Results from Ensemble Integrations

    NASA Astrophysics Data System (ADS)

    Zeebe, Richard E.

    2015-01-01

    Due to the chaotic nature of the solar system, the question of its long-term stability can only be answered in a statistical sense, for instance, based on numerical ensemble integrations of nearby orbits. Destabilization of the inner planets, leading to close encounters and/or collisions can be initiated through a large increase in Mercury's eccentricity, with a currently assumed likelihood of ~1%. However, little is known at present about the robustness of this number. Here I report ensemble integrations of the full equations of motion of the eight planets and Pluto over 5 Gyr, including contributions from general relativity. The results show that different numerical algorithms lead to statistically different results for the evolution of Mercury's eccentricity (e_M}). For instance, starting at present initial conditions (e_M}≃ 0.21), Mercury's maximum eccentricity achieved over 5 Gyr is, on average, significantly higher in symplectic ensemble integrations using heliocentric rather than Jacobi coordinates and stricter error control. In contrast, starting at a possible future configuration (e_M}≃ 0.53), Mercury's maximum eccentricity achieved over the subsequent 500 Myr is, on average, significantly lower using heliocentric rather than Jacobi coordinates. For example, the probability for e_M} to increase beyond 0.53 over 500 Myr is >90% (Jacobi) versus only 40%-55% (heliocentric). This poses a dilemma because the physical evolution of the real system—and its probabilistic behavior—cannot depend on the coordinate system or the numerical algorithm chosen to describe it. Some tests of the numerical algorithms suggest that symplectic integrators using heliocentric coordinates underestimate the odds for destabilization of Mercury's orbit at high initial e_M}.

  18. Internally directed cognition and mindfulness: an integrative perspective derived from predictive and reactive control systems theory

    PubMed Central

    Tops, Mattie; Boksem, Maarten A. S.; Quirin, Markus; IJzerman, Hans; Koole, Sander L.

    2013-01-01

    In the present paper, we will apply the predictive and reactive control systems (PARCS) theory as a framework that integrates competing theories of neural substrates of awareness by describing the “default mode network” (DMN) and anterior insula (AI) as parts of two different behavioral and homeostatic control systems. The DMN, a network that becomes active at rest when there is no external stimulation or task to perform, has been implicated in self-reflective awareness and prospection. By contrast, the AI is associated with awareness and task-related attention. This has led to competing theories stressing the role of the DMN in self-awareness vs. the role of interoceptive and emotional information integration in the AI in awareness of the emotional moment. In PARCS, the respective functions of the DMN and AI in a specific control system explains their association with different qualities of awareness, and how mental states can shift from one state (e.g., prospective self-reflection) to the other (e.g., awareness of the emotional moment) depending on the relative dominance of control systems. These shifts between reactive and predictive control are part of processes that enable the intake of novel information, integration of this novel information within existing knowledge structures, and the creation of a continuous personal context in which novel information can be integrated and understood. As such, PARCS can explain key characteristics of mental states, such as their temporal and spatial focus (e.g., a focus on the here and now vs. the future; a first person vs. a third person perspective). PARCS further relates mental states to brain states and functions, such as activation of the DMN or hemispheric asymmetry in frontal cortical functions. Together, PARCS deepens the understanding of a broad range of mental states, including mindfulness, mind wandering, rumination, autobiographical memory, imagery, and the experience of self. PMID:24904455

  19. Decision making from economic and signal detection perspectives: development of an integrated framework

    PubMed Central

    Lynn, Spencer K.; Wormwood, Jolie B.; Barrett, Lisa F.; Quigley, Karen S.

    2015-01-01

    Behavior is comprised of decisions made from moment to moment (i.e., to respond one way or another). Often, the decision maker cannot be certain of the value to be accrued from the decision (i.e., the outcome value). Decisions made under outcome value uncertainty form the basis of the economic framework of decision making. Behavior is also based on perception—perception of the external physical world and of the internal bodily milieu, which both provide cues that guide decision making. These perceptual signals are also often uncertain: another person's scowling facial expression may indicate threat or intense concentration, alternatives that require different responses from the perceiver. Decisions made under perceptual uncertainty form the basis of the signals framework of decision making. Traditional behavioral economic approaches to decision making focus on the uncertainty that comes from variability in possible outcome values, and typically ignore the influence of perceptual uncertainty. Conversely, traditional signal detection approaches to decision making focus on the uncertainty that arises from variability in perceptual signals and typically ignore the influence of outcome value uncertainty. Here, we compare and contrast the economic and signals frameworks that guide research in decision making, with the aim of promoting their integration. We show that an integrated framework can expand our ability to understand a wider variety of decision-making behaviors, in particular the complexly determined real-world decisions we all make every day. PMID:26217275

  20. Integrated Geophysical Methods Applied to Geotechnical and Geohazard Engineering: From Qualitative to Quantitative Analysis and Interpretation

    NASA Astrophysics Data System (ADS)

    Hayashi, K.

    2014-12-01

    The Near-Surface is a region of day-to-day human activity on the earth. It is exposed to the natural phenomena which sometimes cause disasters. This presentation covers a broad spectrum of the geotechnical and geohazard ways of mitigating disaster and conserving the natural environment using geophysical methods and emphasizes the contribution of geophysics to such issues. The presentation focusses on the usefulness of geophysical surveys in providing information to mitigate disasters, rather than the theoretical details of a particular technique. Several techniques are introduced at the level of concept and application. Topics include various geohazard and geoenvironmental applications, such as for earthquake disaster mitigation, preventing floods triggered by tremendous rain, for environmental conservation and studying the effect of global warming. Among the geophysical techniques, the active and passive surface wave, refraction and resistivity methods are mainly highlighted. Together with the geophysical techniques, several related issues, such as performance-based design, standardization or regularization, internet access and databases are also discussed. The presentation discusses the application of geophysical methods to engineering investigations from non-uniqueness point of view and introduces the concepts of integrated and quantitative. Most geophysical analyses are essentially non-unique and it is very difficult to obtain unique and reliable engineering solutions from only one geophysical method (Fig. 1). The only practical way to improve the reliability of investigation is the joint use of several geophysical and geotechnical investigation methods, an integrated approach to geophysics. The result of a geophysical method is generally vague, here is a high-velocity layer, it may be bed rock, this low resistivity section may contain clayey soils. Such vague, qualitative and subjective interpretation is not worthwhile on general engineering design works

  1. An effective methodology for integrating displacement and velocity data from different sources for rock glaciers monitoring

    NASA Astrophysics Data System (ADS)

    Petitta, Marcello; Thiebes, Benni; Cuozzo, Giovanni; Callegari, Mattia; Schlögel, Romy; Chinellato, Giulia; Kenner, Robert

    2016-04-01

    The monitoring of slope displacements is a necessary task for the management of natural hazards, and a wide array of methodologies, each with their inherent benefits and drawbacks, is available. GNSS measurements, for example, deliver high-accuracy results of positioning for single points but require researchers or technicians to go the field and take the measurements manually. Multi-temporal radar interferometry on the other hand can provide high-accuracy results for large areas; however, displacements are only measured along the line of sight of the satellite. At present, there is no generally accepted method for integrating and assimilating different data into single displacement products. This problem was the starting point of the INTERREG funded research project SloMove in which rock glaciers and deep-seated landslides in Italy and Switzerland were monitored, and the resulting data subsequently assimilated. In our contribution, we focus on the monitoring and data integration results of three active rock glaciers located above the town of Pontresina, (Upper Engadine, Switzerland) for which extensive monitoring was carried out using differential GNSS, terrestrial long-range laserscanning and multi-temporal radar interferometry based on Cosmo SkyMed imagery. Data integration utilised an approach borrowed from atmospheric sciences, i.e. 3DVAR, a method that assimilates different data and minimises errors and uncertainties associated with each data set. Results appear to be very promising; the methodology produces three-dimensional displacement fields for the study site, and the validation, performed while routinely excluding a GNSS measurement site from the computation of the background field, results in linear correlation coefficients between 0.75 and 0.86 and RMSEs in the order of 1mm. Based on our research, we conclude that the assimilation approach represents a clear methodology, largely experimented in other disciplines, which can be routinely used when

  2. Bridging the Gap from Bench to Bedside--An Informatics Infrastructure for Integrating Clinical, Genomics and Environmental Data (ICGED).

    PubMed

    2015-01-01

    The abundance of heterogeneous biomedical data from a variety of sources demands the development of strategies to address data integration and management issues, so that the data can be used effectively in clinical practices and biomedical research. This research presents an Informatics Infrastructure for Integrating Clinical, Genomics and Environmental Data (ICGED) and provides a roadmap that envisions utilizing the clinical and biomedical resources in our case study. This work describes a data integration approach, proposed by ICGED, with a two-fold purpose: personalized medicine and biomedical data storage and sharing platform. It describes our experiences integrating disease specific clinical and genomics datasets with Data Integration and Analysis Tools (DIAT)--using Informatics for Integrating Biology and the Bedside, and discusses work in progress and future work for extending DIAT, and the development of Risk Assessment and Prediction Tools, Clinical Decision Support Systems and a Bioinformatics Data Warehouse. PMID:26262353

  3. Moving Targets, Long-Lived Infrastructure, and Increasing Needs for Integration and Adaptation in Water Management: An Illustration from Switzerland

    PubMed Central

    2011-01-01

    Switzerland provides an example of successful management of water infrastructure and water resources that was accomplished largely without integration across sectors. Limitations in this approach have become apparent; decisions that were formerly based only on technical and economic feasibility must now incorporate broader objectives such as ecological impact. In addition, current and emerging challenges relate to increasingly complex problems that are likely to demand more integrated approaches. If such integration is to be of benefit, it must be possible to redirect resources across sectors, and the synergies derived from integration must outweigh the additional cost of increased complexity. PMID:22208812

  4. Focused attention vs. crossmodal signals paradigm: deriving predictions from the time-window-of-integration model.

    PubMed

    Colonius, Hans; Diederich, Adele

    2012-01-01

    In the crossmodal signals paradigm (CSP) participants are instructed to respond to a set of stimuli from different modalities, presented more or less simultaneously, as soon as a stimulus from any modality has been detected. In the focused attention paradigm (FAP), on the other hand, responses should only be made to a stimulus from a pre-defined target modality and stimuli from non-target modalities should be ignored. Whichever paradigm is being applied, a typical result is that responses tend to be faster to crossmodal stimuli than to unimodal stimuli, a phenomenon often referred to as "crossmodal interaction." Here, we investigate predictions of the time-window-of-integration (TWIN) modeling framework previously proposed by the authors. It is shown that TWIN makes specific qualitative and quantitative predictions on how the two paradigms differ with respect to the probability of multisensory integration and the amount of response enhancement, including the effect of stimulus intensity ("inverse effectiveness"). Introducing a decision-theoretic framework for TWIN further allows comparing the two paradigms with respect to the predicted optimal time window size and its dependence on the prior probability that the crossmodal stimulus information refers to the same event. In order to test these predictions, experimental studies that systematically compare crossmodal effects under stimulus conditions that are identical except for the CSP-FAP instruction should be performed in the future. PMID:22952460

  5. Combinative exposure effect of radio frequency signals from CDMA mobile phones and aphidicolin on DNA integrity.

    PubMed

    Tiwari, R; Lakshmi, N K; Surender, V; Rajesh, A D V; Bhargava, S C; Ahuja, Y R

    2008-01-01

    The aim of present study is to assess DNA integrity on the effect of exposure to a radio frequency (RF) signal from Code Division Multiple Access (CDMA) mobile phones. Whole blood samples from six healthy male individuals were exposed for RF signals from a CDMA mobile phone for 1 h. Alkaline comet assay was performed to assess the DNA damage. The combinative exposure effect of the RF signals and APC at two concentrations on DNA integrity was studied. DNA repair efficiency of the samples was also studied after 2 h of exposure. The RF signals and APC (0.2 microg/ml) alone or in synergism did not have any significant DNA damage as compared to sham exposed. However, univariate analysis showed that DNA damage was significantly different among combinative exposure of RF signals and APC at 0.2 microg/ml (p < 0.05) and at 2 microg/ml (p < 0.02). APC at 2 microg/ml concentration also showed significant damage levels (p < 0.05) when compared to sham exposed. DNA repair efficiency also varied in a significant way in combinative exposure sets (p < 0.05). From these results, it appears that the repair inhibitor APC enhances DNA breaks at 2 microg/ml concentration and that the damage is possibly repairable. Thus, it can be inferred that the in vitro exposure to RF signals induces reversible DNA damage in synergism with APC. PMID:19037791

  6. 3D modeling of a dolerite intrusion from the photogrammetric and geophysical data integration.

    NASA Astrophysics Data System (ADS)

    Duarte, João; Machadinho, Ana; Figueiredo, Fernando; Mira, Maria

    2015-04-01

    The aims of this study is create a methodology based on the integration of data obtained from various available technologies, which allow a credible and complete evaluation of rock masses. In this particular case of a dolerite intrusion, which deployed an exploration of aggregates and belongs to the Jobasaltos - Extracção e Britagem. S.A.. Dolerite intrusion is situated in the volcanic complex of Serra de Todo-o-Mundo, Casais Gaiola, intruded in Jurassic sandstones. The integration of the surface and subsurface mapping, obtained by technology UAVs (Drone) and geophysical surveys (Electromagnetic Method - TEM 48 FAST), allows the construction of 2D and 3D models of the study local. The combination of the 3D point clouds produced from two distinct processes, modeling of photogrammetric and geophysical data, will be the basis for the construction of a single model of set. The rock masses in an integral perspective being visible their development above the surface and subsurface. The presentation of 2D and 3D models will give a perspective of structures, fracturation, lithology and their spatial correlations contributing to a better local knowledge, as well as its potential for the intended purpose. From these local models it will be possible to characterize and quantify the geological structures. These models will have its importance as a tool to assist in the analysis and drafting of regional models. The qualitative improvement in geological/structural modeling, seeks to reduce the value of characterization/cost ratio, in phase of prospecting, improving the investment/benefit ratio. This methodology helps to assess more accurately the economic viability of the projects.

  7. An integrated system for the energy production and accumulation from renewable sources: a rural tower prototype

    NASA Astrophysics Data System (ADS)

    Di Francesco, Silvia; Petrozzi, Alessandro; Montesarchio, Valeria

    2014-05-01

    This research work presents the implementation of an architectural prototype aiming at the complete energy self-sufficiency through an integrated system based on renewable energy. It is suitable for historical buildings in rural areas, isolated but important from natural and architectonical point of view. In addition to the energy aspects, it is important to protect the impact in terms of land-use and environment. This idea is also especially powerful because in the rural countries there are many little building centers abandoned because they are devoid of a connection to the electric energy grid and methane piping. Thus, taking inspiration from dove towers, architectural typology widespread in central Italy, a virtual model has been developed as an integrated system for renewable energy production, storage and supply. While recovering the ancient tower, it is possible to design and assembly an integrated intelligent system, able to combine energy supply and demand: a new tower that should be flexible, efficient and replicable in other contexts as manufacturing, commercial and residential ones. The prototype has been applied to a real case of study, an ancient complex located in Umbria Region. The sources for electric production installed on the tower are photovoltaics, on the head and shaft of the tower, hydropower and a biomass gasifier providing thermal too. A tank at the head of the tower allows an available hydraulic potential energy, for the turbine at any time, to cover photovoltaic lacks, caused by sudden loss of production, for environmental causes. Conversely, photovoltaic peaks, otherwise unusable, can be used to reload the water from the receiving tank at the foot of the tower, up to the tank in the head. The same underground tank acts as a thermal flywheel to optimize the geothermal heat pumps for the heat and cold production. Keywords: hydropower, photovoltaics, dove tower.

  8. Integrative taxonomy and molecular phylogeny of genus Aplysina (Demospongiae: Verongida) from Mexican Pacific.

    PubMed

    Cruz-Barraza, José Antonio; Carballo, José Luis; Rocha-Olivares, Axayacatl; Ehrlich, Hermann; Hog, Martin

    2012-01-01

    Integrative taxonomy provides a major approximation to species delimitation based on integration of different perspectives (e.g. morphology, biochemistry and DNA sequences). The aim of this study was to assess the relationships and boundaries among Eastern Pacific Aplysina species using morphological, biochemical and molecular data. For this, a collection of sponges of the genus Aplysina from the Mexican Pacific was studied on the basis of their morphological, chemical (chitin composition), and molecular markers (mitochondrial COI and nuclear ribosomal rDNA: ITS1-5.8-ITS2). Three morphological species were identified, two of which are new to science. A. clathrata sp. nov. is a yellow to yellow-reddish or -brownish sponge, characterized by external clathrate-like morphology; A. revillagigedi sp. nov. is a lemon yellow to green, cushion-shaped sometimes lobate sponge, characterized by conspicuous oscules, which are slightly elevated and usually linearly distributed on rims; and A. gerardogreeni a known species distributed along the Mexican Pacific coast. Chitin was identified as the main structural component within skeletons of the three species using FTIR, confirming that it is shared among Verongida sponges. Morphological differences were confirmed by DNA sequences from nuclear ITS1-5.8-ITS2. Mitochondrial COI sequences showed extremely low but diagnostic variability for Aplysina revillagigedi sp. nov., thus our results corroborate that COI has limited power for DNA-barcoding of sponges and should be complemented with other markers (e.g. rDNA). Phylogenetic analyses of Aplysina sequences from the Eastern Pacific and Caribbean, resolved two allopatric and reciprocally monophyletic groups for each region. Eastern Pacific species were grouped in general accordance with the taxonomic hypothesis based on morphological characters. An identification key of Eastern Pacific Aplysina species is presented. Our results constitute one of the first approximations to integrative

  9. Integrative Taxonomy and Molecular Phylogeny of Genus Aplysina (Demospongiae: Verongida) from Mexican Pacific

    PubMed Central

    Cruz-Barraza, José Antonio; Carballo, José Luis; Rocha-Olivares, Axayacatl; Ehrlich, Hermann; Hog, Martin

    2012-01-01

    Integrative taxonomy provides a major approximation to species delimitation based on integration of different perspectives (e.g. morphology, biochemistry and DNA sequences). The aim of this study was to assess the relationships and boundaries among Eastern Pacific Aplysina species using morphological, biochemical and molecular data. For this, a collection of sponges of the genus Aplysina from the Mexican Pacific was studied on the basis of their morphological, chemical (chitin composition), and molecular markers (mitochondrial COI and nuclear ribosomal rDNA: ITS1-5.8-ITS2). Three morphological species were identified, two of which are new to science. A. clathrata sp. nov. is a yellow to yellow-reddish or -brownish sponge, characterized by external clathrate-like morphology; A. revillagigedi sp. nov. is a lemon yellow to green, cushion-shaped sometimes lobate sponge, characterized by conspicuous oscules, which are slightly elevated and usually linearly distributed on rims; and A. gerardogreeni a known species distributed along the Mexican Pacific coast. Chitin was identified as the main structural component within skeletons of the three species using FTIR, confirming that it is shared among Verongida sponges. Morphological differences were confirmed by DNA sequences from nuclear ITS1-5.8-ITS2. Mitochondrial COI sequences showed extremely low but diagnostic variability for Aplysina revillagigedi sp. nov., thus our results corroborate that COI has limited power for DNA-barcoding of sponges and should be complemented with other markers (e.g. rDNA). Phylogenetic analyses of Aplysina sequences from the Eastern Pacific and Caribbean, resolved two allopatric and reciprocally monophyletic groups for each region. Eastern Pacific species were grouped in general accordance with the taxonomic hypothesis based on morphological characters. An identification key of Eastern Pacific Aplysina species is presented. Our results constitute one of the first approximations to integrative

  10. WABASH RIVER INTEGRATED METHANOL AND POWER PRODUCTION FROM CLEAN COAL TECHNOLOGIES (IMPPCCT)

    SciTech Connect

    Doug Strickland; Albert Tsang

    2002-10-14

    The Wabash River Integrated Methanol and Power Production from Clean Coal Technologies (IMPPCCT) project is evaluating integrated electrical power generation and methanol production through clean coal technologies. The project is conducted by a multi-industry team lead by Gasification Engineering Corporation (GEC), and supported by Air Products and Chemicals, Inc., Dow Chemical Company, Dow Corning Corporation, Methanex Corporation, and Siemens Westinghouse Power Corporation. Three project phases are planned for execution over a three year period, including: (1) Feasibility study and conceptual design for an integrated demonstration facility, and for fence-line commercial plants operated at Dow Chemical or Dow Corning chemical plant locations; (2) Research, development, and testing to define any technology gaps or critical design and integration issues; and (3) Engineering design and financing plan to install an integrated commercial demonstration facility at the existing Wabash River Energy Limited (WREL) plant in West Terre Haute, Indiana. This report describes management planning, work breakdown structure development, and feasibility study activities by the IMPPCCT consortium in support of the first project phase. Project planning activities have been completed, and a project timeline and task list has been generated. Requirements for an economic model to evaluate the West Terre Haute implementation and for other commercial implementations are being defined. Specifications for methanol product and availability of local feedstocks for potential commercial embodiment plant sites have been defined. The WREL facility is a project selected and co-funded under the fifth phase solicitation of the U.S. Department of Energy's Clean Coal Technology Program. In this project, coal and/or other solid fuel feedstocks are gasified in an oxygen-blown, entrained-flow gasifier with continuous slag removal and a dry particulate removal system. The resulting product synthesis gas

  11. Integrated optic polarization splitter based on total internal reflection from a birefringent polymer.

    PubMed

    Huang, Guanghao; Park, Tae-Hyun; Chu, Woo-Sung; Oh, Min-Cheol

    2016-09-01

    An integrated optic polarization splitter with large fabrication tolerance and high reliability is required for optical signal processing in quantum-encrypted communication systems. A polarization splitter based on total internal reflection from a highly birefringent polymer-reactive mesogen-is proposed and demonstrated in this work. The device consists of a mode expander for reducing the wave vector distribution of the guided mode, and an interface with a large birefringence. Several polymers with suitable refractive indexes were used for fabricating the device. We obtained a polarization splitter with a low crosstalk (less than -30 dB), and a large fabrication tolerance. PMID:27607704

  12. From theory to practice: integrating instructional technology into veterinary medical education.

    PubMed

    Wang, Hong; Rush, Bonnie R; Wilkerson, Melinda; Herman, Cheryl; Miesner, Matt; Renter, David; Gehring, Ronette

    2013-01-01

    Technology has changed the landscape of teaching and learning. The integration of instructional technology into teaching for meaningful learning is an issue for all educators to consider. In this article, we introduce educational theories including constructivism, information-processing theory, and dual-coding theory, along with the seven principles of good practice in undergraduate education. We also discuss five practical instructional strategies and the relationship of these strategies to the educational theories. From theory to practice, the purpose of the article is to share our application of educational theory and practice to work toward more innovative teaching in veterinary medical education. PMID:23975076

  13. INTEGRAL observation of renewed activity from 4U 1608-522

    NASA Astrophysics Data System (ADS)

    Ishibashi, W.; Ferrigno, C.; Sánchez-Fernández, C.; Kuulkers, E.; Chenevez, J.

    2010-03-01

    On 3 March 2010 SuperAGILE detected an X-ray burst from the LMXB 4U 1608-522 (Atel #2461). Confirmation of the renewed activity of this transient source was reported by MAXI/GSC (Atel #2462). 4U1608-522 was in the IBIS/ISGRI and JEMX field of view during several observations between 2010-Feb-23 06:20 and 2010-March-03 01:04 UTC, when INTEGRAL was monitoring the inner Galactic Disk. The source was detected by JEMX since March 2, with a flux of 17+/-2 mCrab in the 3-20 keV band.

  14. An Integrated Hydrogen Production-CO2 Capture Process from Fossil Fuel

    SciTech Connect

    Z. Wang; K. B. Bota

    2005-03-15

    The major project objective is to determine the feasibility of using the char from coal and/or biomass pyrolysis, ammonia and CO2 emissions at smokestacks to produce clean hydrogen and a sequestered carbon fertilizer. During this work period, literature review has been completed. The project plan, design and test schedules were made on the basis of discussion with partner in experimental issues. Installation of pilot scale units was finished and major units tests were fully performed. Modification of the pyrolyzer, reformer and gas absorption tank have been done. Integration testing is performing recently. Lab scale tests are in operation phase. The experimental installations are discussed in this paper.

  15. AN INTEGRATED HYDROGEN PRODUCTION-CO2 CAPTURE PROCESS FROM FOSSIL FUEL

    SciTech Connect

    Z. Wang; K.B. Bota; D. Day

    2004-09-01

    The major project objective is to determine the feasibility of using the char from coal and/or biomass pyrolysis, ammonia and CO{sub 2} emissions at smokestacks to produce clean hydrogen and a sequestered carbon fertilizer. During this work period, literature review has been completed. The project plan, design and test schedules were made on the basis of discussion with partner in experimental issues. Installation of pilot scale units was finished and major units tests were fully performed. Modification of the pyrolyzer, reformer and gas absorption tank have been done. Integration testing is performing recently. Lab scale tests are in operation phase. The experimental installations are discussed in this paper.

  16. WABASH RIVER INTEGRATED METHANOL AND POWER PRODUCTION FROM CLEAN COAL TECHNOLOGIES (IMPPCCT)

    SciTech Connect

    Albert Tsang

    2003-03-14

    The Wabash River Integrated Methanol and Power Production from Clean Coal Technologies (IMPPCCT) project is evaluating integrated electrical power generation and methanol production through clean coal technologies. The project is conducted by a multi-industry team lead by Gasification Engineering Corporation (GEC), and supported by Air Products and Chemicals, Inc., Dow Chemical Company, Dow Corning Corporation, Methanex Corporation, and Siemens Westinghouse Power Corporation. Three project phases are planned for execution, including: (1) Feasibility study and conceptual design for an integrated demonstration facility, and for fence-line commercial embodiment plants (CEP) operated at Dow Chemical or Dow Corning chemical plant locations (2) Research, development, and testing (RD&T) to define any technology gaps or critical design and integration issues (3) Engineering design and financing plan to install an integrated commercial demonstration facility at the existing Wabash River Energy Limited (WREL) plant in West Terre Haute, Indiana. The WREL facility is a project selected and co-funded under the Round IV of the United States Department of Energy's (DOE's) Clean Coal Technology Program. In this project, coal and/or other solid fuel feedstocks are gasified in an oxygen-blown, entrained-flow gasifier with continuous slag removal and a dry particulate removal system. The resulting product synthesis gas is used to fuel a combustion turbine generator whose exhaust is integrated with a heat recovery steam generator to drive a refurbished steam turbine generator. The gasifier uses technology initially developed by The Dow Chemical Company (the Destec Gasification Process), and now offered commercially by Global Energy, Inc., parent company of GEC and WREL, as the E-GAS{trademark} technology. In a joint effort with the DOE, a Cooperative Agreement was awarded under the Early Entrance Coproduction Plant (EECP) solicitation. GEC and an Industrial Consortium are

  17. Integrating local research watersheds into hydrologic education: Lessons from the Dry Creek Experimental Watershed

    NASA Astrophysics Data System (ADS)

    McNamara, J. P.; Aishlin, P. S.; Flores, A. N.; Benner, S. G.; Marshall, H. P.; Pierce, J. L.

    2014-12-01

    While a proliferation of instrumented research watersheds and new data sharing technologies has transformed hydrologic research in recent decades, similar advances have not been realized in hydrologic education. Long-standing problems in hydrologic education include discontinuity of hydrologic topics from introductory to advanced courses, inconsistency of content across academic departments, and difficulties in development of laboratory and homework assignments utilizing large time series and spatial data sets. Hydrologic problems are typically not amenable to "back-of-the-chapter" examples. Local, long-term research watersheds offer solutions to these problems. Here, we describe our integration of research and monitoring programs in the Dry Creek Experimental Watershed into undergraduate and graduate hydrology programs at Boise State University. We developed a suite of watershed-based exercises into courses and curriculums using real, tangible datasets from the watershed to teach concepts not amenable to traditional textbook and lecture methods. The aggregation of exercises throughout a course or degree allows for scaffolding of concepts with progressive exposure of advanced concepts throughout a course or degree. The need for exercises of this type is growing as traditional lecture-based classes (passive learning from a local authoritative source) are being replaced with active learning courses that integrate many sources of information through situational factors.

  18. Chemical constituents in particulate emissions from an integrated iron and steel facility.

    PubMed

    Tsai, Jiun-Horng; Lin, Kuo-Hsiung; Chen, Chih-Yu; Ding, Jian-Yuan; Choa, Ching-Guan; Chiang, Hung-Lung

    2007-08-17

    Particle emissions from four integrated iron and steel plant processes, i.e., coke making, sintering, cold forming, and hot forming, were investigated in this study. Particle compositions of 21 element species, 11 ionic species, elemental carbon (EC), organic carbon (OC) and 16 polyaromatic hydrocarbons (PAHs) were analyzed to create "fingerprints" of the particles emitted from various processes in an integrated iron and steel plant. Results indicated that element compositions (0.11-0.42 g/g), water-soluble ions (0.34-0.52 g/g), elemental carbon (0.008-0.14 g/g), organic carbon (0.02-0.06 g/g) and PAHs (0.52-6.2 mg/g) contributed to the particle mass. In general, sulfur had a higher mass contribution than the other elements, which resulted from the use of coal, flux, heavy oil, and many recycled materials in the iron and steel plant. The particle mass contribution of potassium and chlorine in the sinter plant was higher than in other processes; this may be attributed to the lower boiling point and volatility of potassium. In addition, many recycled materials were fed into the sinter plant, causing a high concentration of potassium and chlorine in the particle phase. Eight PAH compounds were analyzed in the four processes. The carcinogenic compound Benzo(a)pyrene (BaP) was detectable only in the sintering process. PMID:17276592

  19. Preservation of Supported Lipid Membrane Integrity from Thermal Disruption: Osmotic Effect.

    PubMed

    Zhu, Tao; Jiang, Zhongying; Ma, Yuqiang; Hu, Yong

    2016-03-01

    Preservation of structural integrity under various environmental conditions is one major concern in the development of the supported lipid membrane (SLM)-based devices. It is common for SLMs to experience temperature shifts from manufacture, processing, storage, and transport to operation. In this work, we studied the thermal adaption of the supported membranes on silica substrates. Homogenous SLMs with little defects were formed through the vesicle fusion method. The mass and fluidity of the bilayers were found to deteriorate from a heating process but not a cooling process. Fluorescence characterizations showed that the membranes initially budded as a result of heating-induced lipid lateral area expansion, followed by the possible fates including maintenance, retraction, and fission, among which the last contributes to the irreversible compromise of the SLM integrity and spontaneous release of the interlipid stress accumulated. Based on the mechanism, we developed a strategy to protect SLMs from thermal disruption by increasing the solute concentration in medium. An improved preservation of the membrane mass and fluidity against the heating process was observed, accompanied by a decrease in the retraction and fission of the buds. Theoretical analysis revealed a high osmotic energy penalty for the fission, which accounts for the depressed disruption. This osmotic-based protection strategy is facile, solute nonspecific, and long-term efficient and has little impact on the original SLM properties. The results may help broaden SLM applications and sustain the robustness of SLM-based devices under multiple thermal conditions. PMID:26886864

  20. An integrated model-based approach to the risk assessment of pesticide drift from vineyards

    NASA Astrophysics Data System (ADS)

    Pivato, Alberto; Barausse, Alberto; Zecchinato, Francesco; Palmeri, Luca; Raga, Roberto; Lavagnolo, Maria Cristina; Cossu, Raffaello

    2015-06-01

    The inhalation of pesticide in air is of particular concern for people living in close contact with intensive agricultural activities. This study aims to develop an integrated modelling methodology to assess whether pesticides pose a risk to the health of people living near vineyards, and apply this methodology in the world-renowned Prosecco DOCG (Italian label for protection of origin and geographical indication of wines) region. A sample field in Bigolino di Valdobbiadene (North-Eastern Italy) was selected to perform the pesticide fate modellization and the consequent inhalation risk assessment for people living in the area. The modellization accounts for the direct pesticide loss during the treatment of vineyards and for the volatilization from soil after the end of the treatment. A fugacity model was used to assess the volatilization flux from soil. The Gaussian puff air dispersion model CALPUFF was employed to assess the airborne concentration of the emitted pesticide over the simulation domain. The subsequent risk assessment integrates the HArmonised environmental Indicators for pesticide Risk (HAIR) and US-EPA guidelines. In this case study the modelled situation turned to be safe from the point of view of human health in the case of non-carcinogenic compounds, and additional improvements were suggested to further mitigate the effect of the most critical compound.