Sample records for nash western ridge

  1. Molecular Pathogenesis of NASH

    PubMed Central

    Caligiuri, Alessandra; Gentilini, Alessandra; Marra, Fabio

    2016-01-01

    Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the Western world and a major health problem, owing to its close association with obesity, diabetes, and the metabolic syndrome. NASH progression results from numerous events originating within the liver, as well as from signals derived from the adipose tissue and the gastrointestinal tract. In a fraction of NASH patients, disease may progress, eventually leading to advanced fibrosis, cirrhosis and hepatocellular carcinoma. Understanding the mechanisms leading to NASH and its evolution to cirrhosis is critical to identifying effective approaches for the treatment of this condition. In this review, we focus on some of the most recent data reported on the pathogenesis of NASH and its fibrogenic progression, highlighting potential targets for treatment or identification of biomarkers of disease progression. PMID:27657051

  2. Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol.

    PubMed

    Henkel, Janin; Coleman, Charles Dominic; Schraplau, Anne; Jӧhrens, Korinna; Weber, Daniela; Castro, José Pedro; Hugo, Martin; Schulz, Tim Julius; Krämer, Stephanie; Schürmann, Annette; Püschel, Gerhard Paul

    2017-03-21

    Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or metabolic syndrome such as hepatic inflammation and fibrosis (e.g. high-fat diets) or overweight and insulin resistance (e.g. methionine-choline-deficient diets) or they are based on monogenetic defects (e.g. ob/ob mice). In the current study, a western-type diet containing soybean oil with high n 6-PUFA and 0.75% cholesterol (SOD+Cho) induced steatosis, inflammation and fibrosis accompanied by hepatic lipid peroxidation and oxidative stress in livers of C57BL/6-mice which in addition showed increased weight gain and insulin resistance, thus displaying a phenotype closely resembling all clinical features of NASH in patients with metabolic syndrome. In striking contrast a soybean oil-containing western-type diet without cholesterol (SOD) induced only mild steatosis but neither hepatic inflammation nor fibrosis, weight gain or insulin resistance. Another high-fat diet mainly consisting of lard and supplemented with fructose in drinking water (LAD+Fru) resulted in more prominent weight gain, insulin resistance and hepatic steatosis than SOD+Cho but livers were devoid of inflammation and fibrosis. Although both LAD+Fru- and SOD+Cho-fed animals had high plasma cholesterol, liver cholesterol was elevated only in SOD+Cho animals. Cholesterol induced expression of chemotactic and inflammatory cytokines in cultured Kupffer cells and rendered hepatocytes more susceptible to apoptosis. Summarizing, dietary cholesterol in SOD+Cho diet may trigger hepatic inflammation and fibrosis. SOD+Cho-fed animals may be a useful disease model displaying many clinical features of patients with the metabolic syndrome and NASH.

  3. Gravitational spreading of steep-sided ridges ("sackung") in Western United States

    USGS Publications Warehouse

    Radbruch-Hall, D. H.; Varnes, D.J.; Savage, W.Z.

    1976-01-01

    Large-scale gravitational spreading and movement along fractures of steep-sided ridges in the mountainous areas of the western United States are characterized by linear fissures, trenches, and uphill-facing scarps on tops and sides of ridges. Spreading appears to take place by movement along disconnected planes and/or by slow plastic deformation of a rock mass. In some places, valleyward squeezing out of weak shales overlain by rigid rocks causes extensional fracturing and outward movement of the rigid layers, as illustrated by extension of two laccoliths overlying Mancos Shale, one at Dolores Peak and another at Crested Butte in western Colorado. Gravitational forces acting on a ridge of more homogeneous material causes tensional spreading of the ridge parallel to its long axis, for example in fractured granitic rock north of Mt. Massive in central Colorado, where a survey course has been established to monitor the movement. Recognition and understanding of these large-scale gravitational features and the mechanism that causes them are pertinent to site selection and design of engineering structures in high mountains. If fractures extend to considerable depth and if movement is continuing, engineering structures in valleys or tunnels through the spreading ridges could be damaged. ?? 1976 International Association of Engineering Geology.

  4. Structure and origin of the J Anomaly Ridge, western North Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Tucholke, Brian E.; Ludwig, William J.

    1982-11-01

    The J Anomaly Ridge is a structural ridge or step in oceanic basement that extends southwest from the eastern end of the Grand Banks. It lies beneath the J magnetic anomaly at the young end (M-4 to M-0) of the M series magnetic anomalies. Its structural counterpart beneath the J anomaly in the eastern Atlantic is the Madeira-Tore Rise, but this feature has been overprinted by post-middle Cretaceous deformation and volcanism. In order to study the origin and evolution of the J Anomaly Ridge-Madeira-Tore Rise system, we obtained seismic refraction and multichannel reflection profiles across the J Anomaly Ridge near 39°N latitude. The western ridge flank consists of a series of crustal blocks downdropped along west-dipping normal faults, but the eastern slope to younger crust is gentle and relatively unfaulted. The western flank also is subparallel to seafloor isochrons, becoming younger to the south. Anomalously smooth basement caps the ridge crest, and it locally exhibits internal, eastward-dipping reflectors similar in configuration to those within subaerially emplaced basalt flows on Iceland. When isostatically corrected for sediment load, the northern part of the J Anomaly Ridge has basement depths about 1400 m shallower than in our study area, and deep sea drilling has shown that the northern ridge was subaerially exposed during the middle Cretaceous. We suggest that most of the system originated under subaerial conditions at the time of late-stage rifting between the adjacent Grand Banks and Iberia. The excess magma required to form the ridge may have been vented from a mantle plume beneath the Grand Banks-Iberia rift zone and channelled southward beneath the rift axis of the abutting Mid-Atlantic Ridge. Resulting edifice-building volcanism constructed the ridge system between anomalies M-4 and M-0, moving southward along the ridge axis at about 50 mm/yr. About M-0 time, when true drift began between Iberia and the Grand Banks, this southward venting rapidly

  5. A biomarker panel for non-alcoholic steatohepatitis (NASH) and NASH-related fibrosis.

    PubMed

    Younossi, Zobair M; Page, Sandra; Rafiq, Nila; Birerdinc, Aybike; Stepanova, Maria; Hossain, Noreen; Afendy, Arian; Younoszai, Zahra; Goodman, Zachary; Baranova, Ancha

    2011-04-01

    Patients with biopsy-proven NASH and especially those with fibrosis are at risk for progressive liver disease, emphasizing the clinical importance of developing non-invasive biomarkers for NASH and NASH-related fibrosis. This study examines the performance of a new biomarker panel for NASH and NASH-related fibrosis with a combination of clinical and laboratory variables. Enrolled patients had biopsy-proven NAFLD. Clinical data, laboratory data, and serum samples were collected at the time of biopsy. Fasting serum was assayed for adiponectin, resistin, glucose, M30, M65, Tissue inhibitor of metalloproteinases-1 (Timp-1), ProCollagen 3 N-terminal peptide (PIIINP), and hyaluronic acid (HA). Regression models predictive of NASH, NASH-related fibrosis, and NASH-related advanced fibrosis were designed and cross-validated. Of the 79 enrolled NAFLD patients, 40 had biopsy-proven NASH and 39 had non-NASH NAFLD. Clinical and laboratory data were from this cohort were used to develop a NAFLD Diagnostic Panel that includes three models (models for NASH, NASH-related fibrosis, and NASH-related advanced fibrosis). The model for predicting NASH includes diabetes, gender, BMI, triglycerides, M30 (apoptosis), and M65-M30 (necrosis) [AUC: 0.81, 95% CI, 0.70-0.89, 300 p value <9E 301 (-06)]. The NASH-related fibrosis prediction model includes the same predictors [AUC: 0.80, 95% CI 0.68-0.88, 307 p value <0.00014]. Finally, the NASH-related advanced fibrosis model includes type 2 diabetes, serum triglycerides, Timp-1, and AST [AUC: 0.81, 95% CI, 0.70-0.89; p value, 0.000062]. This NAFLD Diagnostic Panel based on a clinical and laboratory data has good performance characteristics and is easy to use. This biomarker panel could become useful in the management of patients with NAFLD.

  6. Basalts dredged from the Amirante ridge, western Indian ocean

    USGS Publications Warehouse

    Fisher, R.L.; Engel, C.G.; Hilde, T.W.C.

    1968-01-01

    Oceanic tholeiitic basalts were dredged from 2500 to 3000 m depth on each flank of the Amirante Ridge, 1200 km southeast of Somalia in the western Indian Ocean, by R.V. Argo in 1964. One sample, probably shed from a flow or dike in basement beneath the coralline cap, gave a wholerock KAr age of 82??16??106 years. The age is similar to those reported by others for agglomerate from Providence Reef, nearer Madagascar, and for gabbro from Chain Ridge, the southwest member of Owen Fracture Zone, nearer the Somali coast. The Amirante Cretaceous-Early Tertiary occurrence lies between the "continental" 650 ?? 106 years granites of Seychelles Archipelago and the large Precambrian "continental" block of Madagascar. Trends of major structures and distribution of the related topographic and magnetic-anomaly lineations in 7-8 ?? 106 km2of the surrounding Indian Ocean suggest that in addition to spreading of the seafloor from the seismically-active Mid-Indian Ocean Ridge-Carlsberg Ridge complex there has been, since mid-Mesozoic time, distributed left-lateral shear along 52??-54??E that has moved Madagascar at least 700 km south relative to Seychelles Bank. Measurements by other indicate the absolute movement of Madagascar has been southward as well. The emplacement of oceanic tholeiitic basalts at shallow depth, the development of volcanic topography between the sedimented Somali and Mascarene basins, and the existence of the faulted Amirante Trench and Ridge are consequences of the displacement. ?? 1968.

  7. The Effects of Aseismic Ridge Collision on Upper Plate Deformation: Cocos Ridge Collision and Deformation of the Western Caribbean

    NASA Astrophysics Data System (ADS)

    La Femina, P. C.; Govers, R. M. A.; Ruiz, G.; Geirsson, H.; Camacho, E.; Mora-Paez, H.

    2015-12-01

    The collision of the Panamanian isthmus with northwestern South America is thought to have initiated as early as Oligocene - Miocene time (23-25 Ma) based on geologic and geophysical data and paleogeographic reconstructions. This collision was driven by eastward-directed subduction beneath northwestern South America. Cocos - Caribbean convergence along the Middle America Trench, and Nazca - Caribbean oblique convergence along the South Panama Deformed Belt have resulted in complex deformation of the southwestern Caribbean since Miocene - Pliocene time. Subduction and collision of the aseismic Cocos Ridge is thought to have initiated <3.5 Ma and has been linked to: 1) late Miocene-Pliocene cessation of volcanism and uplift of the Cordillera de Talamanca, Costa Rica; 2) Quaternary migration of the volcanic arc toward the back-arc in Costa Rica; 3) Quaternary to present deformation within the Central Costa Rica Deformed Belt; 4) Quaternary to present shortening across the fore-arc Fila Costeña fold and thrust belt and back-arc North Panama Deformed Belt (NPDB); 5) Quaternary to present outer fore-arc uplift of Nicoya Peninsula above the seamount domain, and the Osa and Burica peninsulas above the ridge; and 6) Pleistocene to present northwestward motion of the Central American Fore Arc (CAFA) and northeastward motion of the Panama Region. We investigate the geodynamic effects of Cocos Ridge collision on motion of the Panama Region with a new geodynamic model. The model is compared to a new 1993-2015 GPS-derived three-dimensional velocity field for the western Caribbean and northwestern South America. Specifically, we test the hypotheses that the Cocos Ridge is the main driver for upper plate deformation in the western Caribbean. Our models indicate that Cocos Ridge collision drives northwest-directed motion of the CAFA and the northeast-directed motion of the Panama Region. The Panama Region is driven into the Caribbean across the NPDB and into northwestern South

  8. Progression and Regression of Hepatic Lesions in a Mouse Model of NASH Induced by Dietary Intervention and Its Implications in Pharmacotherapy.

    PubMed

    Ding, Zhi-Ming; Xiao, Yue; Wu, Xikun; Zou, Haixia; Yang, Shurong; Shen, Yiyun; Xu, Juehua; Workman, Heather C; Usborne, Amy L; Hua, Haiqing

    2018-01-01

    Understanding of the temporal changes of hepatic lesions in the progression and regression of non-alcoholic steatohepatitis (NASH) is vital to elucidation of the pathogenesis of NASH, and critical to the development of a strategy for NASH pharmacotherapy. There are challenges in studying hepatic lesion progression and regression in NASH patients due to the slow development of NASH in humans, one being the requirement for multiple biopsies during the longitudinal follow-up. Here we studied lesion progression and regression in the diet-induced animal model of NASH by application or removal of the pathogenic diet for multiple time periods. Male C57BL/6 mice fed Western diet developed progressive hepatic steatosis/macrovesicular vacuolation, inflammation, and hepatocyte degeneration, as well as perisinusoidal fibrosis and occasionally portal fibrosis as early as 2 months after initiation of the Western diet. In the same period, the mice exhibited elevated ALT (alanine aminotransferase) and AST (aspartate aminotransferase) enzyme activities, CK18 (cytokeratin-18), PIIINP (N-terminal propeptide of type III collagen), and TIMP-1 (tissue inhibitor of metalloproteinase-1). Hepatic steatosis diminished rapidly when the Western diet was replaced by normal rodent chow diet and hepatic inflammation and hepatocyte degeneration were also reduced. Interestingly, perisinusoidal fibrosis and portal fibrosis regressed 8 months after chow diet replacement. To understand pharmacotherapy for NASH, mice with established NASH hepatic lesions were treated with either FXR agonist obeticholic acid (Ocaliva), or CCR2/5 antagonist Cenicriviroc. Similar to the diet replacement, metabolic modulator Ocaliva markedly reduced steatosis/macrovesicular vacuolation, hepatic inflammation, and hepatocyte degeneration effectively, but exhibited no significant effect on liver fibrosis. Anti-inflammation drug Cenicriviroc, on the other hand, markedly decreased inflammation and hepatocyte degeneration, and

  9. A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH).

    PubMed

    Srivastava, Jyoti; Robertson, Chadia L; Ebeid, Kareem; Dozmorov, Mikhail; Rajasekaran, Devaraja; Mendoza, Rachel; Siddiq, Ayesha; Akiel, Maaged A; Jariwala, Nidhi; Shen, Xue-Ning; Windle, Jolene J; Subler, Mark A; Mukhopadhyay, Nitai D; Giashuddin, Shah; Ghosh, Shobha; Lai, Zhao; Chen, Yidong; Fisher, Paul B; Salem, Aliasger K; Sanyal, Arun J; Sarkar, Devanand

    2017-08-01

    Nonalcoholic steatohepatitis (NASH) is the most prevalent cause of chronic liver disease in the Western world. However, an optimum therapy for NASH is yet to be established, mandating more in-depth investigation into the molecular pathogenesis of NASH to identify novel regulatory molecules and develop targeted therapies. Here, we unravel a unique function of astrocyte elevated gene-1(AEG-1)/metadherin in NASH using a transgenic mouse with hepatocyte-specific overexpression of AEG-1 (Alb/AEG-1) and a conditional hepatocyte-specific AEG-1 knockout mouse (AEG-1 ΔHEP ). Alb/AEG-1 mice developed spontaneous NASH whereas AEG-1 ΔHEP mice were protected from high-fat diet (HFD)-induced NASH. Intriguingly, AEG-1 overexpression was observed in livers of NASH patients and wild-type (WT) mice that developed steatosis upon feeding HFD. In-depth molecular analysis unraveled that inhibition of peroxisome proliferator-activated receptor alpha activity resulting in decreased fatty acid β-oxidation, augmentation of translation of fatty acid synthase resulting in de novo lipogenesis, and increased nuclear factor kappa B-mediated inflammation act in concert to mediate AEG-1-induced NASH. Therapeutically, hepatocyte-specific nanoparticle-delivered AEG-1 small interfering RNA provided marked protection from HFD-induced NASH in WT mice. AEG-1 might be a key molecule regulating initiation and progression of NASH. AEG-1 inhibitory strategies might be developed as a potential therapeutic intervention in NASH patients. (Hepatology 2017;66:466-480). © 2017 by the American Association for the Study of Liver Diseases.

  10. The Nash equilibrium: A perspective

    PubMed Central

    Holt, Charles A.; Roth, Alvin E.

    2004-01-01

    In 1950, John Nash contributed a remarkable one-page PNAS article that defined and characterized a notion of equilibrium for n- person games. This notion, now called the “Nash equilibrium,” has been widely applied and adapted in economics and other behavioral sciences. Indeed, game theory, with the Nash equilibrium as its centerpiece, is becoming the most prominent unifying theory of social science. In this perspective, we summarize the historical context and subsequent impact of Nash's contribution. PMID:15024100

  11. Nash: genius with schizophrenia or vice versa?

    PubMed

    Funaki, Tevita

    2009-11-01

    Schizophrenia has many negative impacts on the wellbeing of individuals (sufferers). I will critically analyse Nash's experience with his illness of schizophrenia and his concept of wellness based on themes, his journey with schizophrenia and the support of this wife and friends. Ron Howard directed the movie, A Beautiful Mind based on Nash's biography about his mathematical genius and his struggle with schizophrenia. Nash only had one sister, Martha Nash who was born on November 16th, 1930. In terms of his mental health and wellness, Nash began to show signs of schizophrenia in 1958, on the threshold of his career. After 1970, by his choice, he never took antipsychotic medication again. In 1978, Nash was awarded the John von Neumann Theory Prize for his discovery of non-cooperative equilibria, now called Nash equilibria. As a result of Nash's illness, he adopted unhealthy practices that did not help him cope with schizophrenia. Recovery from mental illness has emphasised the importance of hope for the people experiencing mental illness. Nash's self-determinations enabled him to overcome the stigmatisation suffering due to schizophrenia. Nash experienced the five stages of coping with mental illness. The support of Nash's wife Alicia and the few close friends he had were paramount to his recovery and living with schizophrenia. Alicia had used cognitive coping strategies with her caring for Nash by having positive thinking in attempting to accept Nash's illness rather than denying that it existed and to understand the life experiences of a person with schizophrenia. Howard (2001) stated that it's about a 25% chance, that survivors of schizophrenia can regain clarity as Nash did within a certain time period.

  12. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1

    PubMed Central

    Matsushita, Noriko; Hassanein, Mohamed T.; Martinez-Clemente, Marcos; Lazaro, Raul; French, Samuel W.; Xie, Wen; Lai, Keane; Karin, Michael; Tsukamoto, Hidekazu

    2017-01-01

    Myeloid cell and hepatocyte IKKβ may mediate the genesis of obesity and insulin resistance in mice fed high fat diet. However, their gender-specific roles in the pathogenesis of non-alcoholic steatohepatitis (NASH) are not known. Here we demonstrate myeloid IKKβ deficiency prevents Western diet-induced obesity and visceral adiposity in females but not in males, and attenuates hyperglycemia, global IR, and NASH in both genders. In contrast, all metabolic sequela including NASH are aggravated by hepatocyte IKKβ deficiency (IkbkbΔhep) in male but not female mice. Gene profiling identifies sulfotransferase family 1E (Sult1e1), which encodes a sulfotransferase E1 responsible for inactivation of estrogen, as a gene upregulated in NASH in both genders and most conspicuously in male IkbkbΔhep mice having worst NASH and lowest plasma estradiol levels. LXRα is enriched to LXRE on Sult1e1 promoter in male WT and IkbkbΔhep mice with NASH, and a Sult1e1 promoter activity is increased by LXRα and its ligand and augmented by expression of a S32A mutant of IκBα. These results demonstrate striking gender differences in regulation by IKKβ of high cholesterol saturated fat diet-induced metabolic changes including NASH and suggest hepatocyte IKKβ is protective in male due at least in part to its ability to repress LXR-induced Sult1e1. Our findings also raise a caution for systemic IKK inhibition for the treatment of NASH as it may exacerbate the disease in male patients. PMID:28797077

  13. Tomographic Signatures of Ridge Subduction Along Western North America: Implications for Northern Cordillera Plate Tectonics Since the Cretaceous

    NASA Astrophysics Data System (ADS)

    Lin, Y. A.; Wu, J.

    2017-12-01

    A number of northern Cordillera plate reconstructions have predicted subduction of the Kula-Farallon ridge and possibly other ridges along western North America after the late Mesozoic. The timing and location of these predicted ridge subduction events have been controversial, with implications for rapid northward terrane motions (i.e. the Baja-British Columbia hypothesis). In contrast, Sigloch and Mihalynuk (2013) proposed an archipelago-style plate model that placed one or several Jurassic-Cretaceous ocean basins between the Farallon plate and western North America, which apparently would preclude any sustained Kula-Farallon ridge subduction along western North America. In this study we test the viability of these models by mapping and unfolding subducted slabs from MITP08 tomography (Li et al., 2008) between Alaska and California within the upper 1500 km mantle. Our aim was to locate significant slab gaps that might be related to ancient ridge subduction `slab windows'. Tomographic velocities were extracted and displayed on our mapped slabs following the methods of Wu et al. (2016) to assist with the identification of slab gaps or windows. Near Alaska, we mapped the Aleutian slab and a detached slab that was previously identified as the `K slab' by Sigloch and Mihalynuk (2013). When unfolded these slabs apparently account for Pacific-Kula convergence towards Alaska since the late Cretaceous. We did not find evidence for a ridge subduction-related slab gap under the Alaskan region. Between northern Canada to California, we mapped the Juan de Fuca slab and several detached slabs at 1000 to 1500 km depths that were previously identified by Sigloch and Mihalynuk (2013). The velocity perturbations within our mapped slabs revealed slower P-wavespeed `slab gaps' under southernmost Alaska, Yukon, and British Columbia between the mapped Kula and Juan de Fuca plate. We did not find evidence of the hypothesized Resurrection plate. We compare our mapped slab gaps to

  14. Wrestling J. B. Nash.

    ERIC Educational Resources Information Center

    Ellis, Gary D.

    This paper focuses on how between 1965 and the present, the field of recreation has and has not accomplished the goals of author and educator J. B. Nash's in regard to recreation, physical education, and health, focusing on public recreation sponsored by city governments, county governments, and special tax districts. The paper looks at Nash's…

  15. Is cryptogenic cirrhosis different from NASH cirrhosis?

    PubMed

    Thuluvath, Paul J; Kantsevoy, Sergey; Thuluvath, Avesh J; Savva, Yulia

    2018-03-01

    We hypothesized that patients currently diagnosed with cryptogenic cirrhosis (CC) have truly 'cryptogenic' liver disease, which is unlikely to have evolved from NASH. The aim of this study is to characterize patients with CC, and compare their characteristics to patients with cirrhosis of other etiologies. To investigate this, we compared the clinical characteristics of adults with CC (n = 7,999) to those with cirrhosis caused by non-alcoholic steatohepatitis (NASH) (n = 11,302), alcohol (n = 21,714) and autoimmune hepatitis (n = 3,447), using the UNOS database from 2002-16. We performed an age, gender and year of listing matched comparison of CC and NASH (n = 7,201 in each group), and also stratified patients by the presence of obesity or diabetes mellitus (DM). From 2002 to 2016, patients listed with a diagnosis of NASH increased from about 1% to 16% while CC decreased from 8% to 4%. A logistic regression model using the entire United Network for Organ Sharing data (n = 138,021) suggested that the strongest predictors of NASH were type 2 DM, obesity, age ≥60 years, female gender and white race. Type 2 DM was more common in patients with NASH (53%) than those with CC (29%), alcoholic cirrhosis (16%) and autoimmune hepatitis (16%), and obesity was more common in NASH (65.3%) compared to the other three groups (33-42%). There were more white individuals (82.3%) in the NASH group and a lower prevalence of black, Hispanic and Asian individuals, compared to the other three groups. Hepatocellular carcinoma was more commonly seen in NASH (19% vs. 9-13% in the other groups) and this is not influenced by obesity and type 2 DM. The differences between CC and NASH remained unchanged even when two groups were matched for age, gender and year of listing, or when stratified by the presence or absence of obesity or type 2DM. Based on risk perspectives, CC should not be equated with the term 'NASH cirrhosis'. We hypothesized that cryptogenic cirrhosis

  16. Dendritic Cells Limit Fibro-Inflammatory Injury in NASH

    PubMed Central

    Henning, Justin R.; Graffeo, Christopher S.; Rehman, Adeel; Fallon, Nina C.; Zambirinis, Constantinos P.; Ochi, Atsuo; Barilla, Rocky; Jamal, Mohsin; Deutsch, Michael; Greco, Stephanie; Ego-Osuala, Melvin; Saeed, Usama Bin; Rao, Raghavendra S.; Badar, Sana; Quesada, Juan P.; Acehan, Devrim; Miller, George

    2013-01-01

    Non-alcoholic steatohepatitis (NASH) is the most common etiology of chronic liver dysfunction in the United States and can progress to cirrhosis and liver failure. Inflammatory insult resulting from fatty infiltration of the liver is central to disease pathogenesis. Dendritic cells (DC) are antigen presenting cells with an emerging role in hepatic inflammation. We postulated that DC are important in the progression of NASH. We found that intrahepatic DC expand and mature in NASH liver and assume an activated immune-phenotype. However, rather than mitigating the severity of NASH, DC depletion markedly exacerbated intrahepatic fibro-inflammation. Our mechanistic studies support a regulatory role for DC in NASH by limiting sterile inflammation via their role in clearance of apoptotic cells and necrotic debris. We found that DC limit CD8+ T cell expansion and restrict Toll-like receptor expression and cytokine production in innate immune effector cells in NASH, including Kupffer cells, neutrophils, and inflammatory monocytes. Consistent with their regulatory role in NASH, during the recovery phase of disease, ablation of DC populations results in delayed resolution of intrahepatic inflammation and fibroplasia. Conclusion Our findings support a role for DC in modulating NASH. Targeting DC functional properties may hold promise for therapeutic intervention in NASH. PMID:23322710

  17. Surface sediment response to deepwater circulation on the Blake Outer Ridge, western North Atlantic: paleoceanographic implications

    NASA Astrophysics Data System (ADS)

    Haskell, Brian J.; Johnson, Thomas C.

    1993-01-01

    Two transects of box core, hydrographic and photographic stations were made along the Blake Outer Ridge on the southeastern U.S. continental rise to study how circulation patterns affect surface sediment properties. Circulation is strongest at 4200 m on the flanks of the ridge and is reflected in the suspended particulate distribution. A second turbidity maximum at 3600 m suggests that there may be a second axis of circulation at this depth. The intense circulation on the flanks of the ridge has resulted in winnowing of the sediment revealed by coarsening and flattening of the grain size distribution in the detrital silt fraction, and concentration of carbonate by the formation of a foraminiferal lag deposit. The mean grain size of the detrital silt fraction on the crest of the ridge decreases southeastwards with increasing distance from upstream sediment sources. Shifts in the position and strength of the Western Boundary Undercurrent affect the distance that relatively coarse silt is transported. Downcore changes in grain size can therefore be used as paleoceanographic proxy for changes in deepwater circulation.

  18. Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

    PubMed

    van Koppen, Arianne; Verschuren, Lars; van den Hoek, Anita M; Verheij, Joanne; Morrison, Martine C; Li, Kelvin; Nagabukuro, Hiroshi; Costessi, Adalberto; Caspers, Martien P M; van den Broek, Tim J; Sagartz, John; Kluft, Cornelis; Beysen, Carine; Emson, Claire; van Gool, Alain J; Goldschmeding, Roel; Stoop, Reinout; Bobeldijk-Pastorova, Ivana; Turner, Scott M; Hanauer, Guido; Hanemaaijer, Roeland

    2018-01-01

    The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for hepatic fibrosis. A time-course study in low-density lipoprotein-receptor knockout. Leiden mice on a high-fat diet was performed to identify the temporal dynamics of key processes contributing to NASH and fibrosis. An integrative systems biology approach was used to elucidate candidate markers linked to the active fibrosis process by combining transcriptomics, dynamic proteomics, and histopathology. The translational value of these findings were confirmed using human NASH data sets. High-fat-diet feeding resulted in obesity, hyperlipidemia, insulin resistance, and NASH with fibrosis in a time-dependent manner. Temporal dynamics of key molecular processes involved in the development of NASH were identified, including lipid metabolism, inflammation, oxidative stress, and fibrosis. A data-integrative approach enabled identification of the active fibrotic process preceding histopathologic detection using a novel molecular fibrosis signature. Human studies were used to identify overlap of genes and processes and to perform a network biology-based prioritization to rank top candidate markers representing the early manifestation of fibrosis. An early predictive molecular signature was identified that marked the active profibrotic process before histopathologic fibrosis becomes manifest. Early detection of the onset of NASH and fibrosis enables identification of novel blood-based biomarkers to stratify patients at risk, development of new therapeutics, and help shorten (pre)clinical experimental time frames.

  19. Computing Nash equilibria through computational intelligence methods

    NASA Astrophysics Data System (ADS)

    Pavlidis, N. G.; Parsopoulos, K. E.; Vrahatis, M. N.

    2005-03-01

    Nash equilibrium constitutes a central solution concept in game theory. The task of detecting the Nash equilibria of a finite strategic game remains a challenging problem up-to-date. This paper investigates the effectiveness of three computational intelligence techniques, namely, covariance matrix adaptation evolution strategies, particle swarm optimization, as well as, differential evolution, to compute Nash equilibria of finite strategic games, as global minima of a real-valued, nonnegative function. An issue of particular interest is to detect more than one Nash equilibria of a game. The performance of the considered computational intelligence methods on this problem is investigated using multistart and deflection.

  20. Local Nash equilibrium in social networks.

    PubMed

    Zhang, Yichao; Aziz-Alaoui, M A; Bertelle, Cyrille; Guan, Jihong

    2014-08-29

    Nash equilibrium is widely present in various social disputes. As of now, in structured static populations, such as social networks, regular, and random graphs, the discussions on Nash equilibrium are quite limited. In a relatively stable static gaming network, a rational individual has to comprehensively consider all his/her opponents' strategies before they adopt a unified strategy. In this scenario, a new strategy equilibrium emerges in the system. We define this equilibrium as a local Nash equilibrium. In this paper, we present an explicit definition of the local Nash equilibrium for the two-strategy games in structured populations. Based on the definition, we investigate the condition that a system reaches the evolutionary stable state when the individuals play the Prisoner's dilemma and snow-drift game. The local Nash equilibrium provides a way to judge whether a gaming structured population reaches the evolutionary stable state on one hand. On the other hand, it can be used to predict whether cooperators can survive in a system long before the system reaches its evolutionary stable state for the Prisoner's dilemma game. Our work therefore provides a theoretical framework for understanding the evolutionary stable state in the gaming populations with static structures.

  1. Local Nash Equilibrium in Social Networks

    NASA Astrophysics Data System (ADS)

    Zhang, Yichao; Aziz-Alaoui, M. A.; Bertelle, Cyrille; Guan, Jihong

    2014-08-01

    Nash equilibrium is widely present in various social disputes. As of now, in structured static populations, such as social networks, regular, and random graphs, the discussions on Nash equilibrium are quite limited. In a relatively stable static gaming network, a rational individual has to comprehensively consider all his/her opponents' strategies before they adopt a unified strategy. In this scenario, a new strategy equilibrium emerges in the system. We define this equilibrium as a local Nash equilibrium. In this paper, we present an explicit definition of the local Nash equilibrium for the two-strategy games in structured populations. Based on the definition, we investigate the condition that a system reaches the evolutionary stable state when the individuals play the Prisoner's dilemma and snow-drift game. The local Nash equilibrium provides a way to judge whether a gaming structured population reaches the evolutionary stable state on one hand. On the other hand, it can be used to predict whether cooperators can survive in a system long before the system reaches its evolutionary stable state for the Prisoner's dilemma game. Our work therefore provides a theoretical framework for understanding the evolutionary stable state in the gaming populations with static structures.

  2. Significant Centers of Tectonic Activity as Identified by Wrinkle Ridges for the Western Hemisphere of Mars

    NASA Technical Reports Server (NTRS)

    Anderson, R.C.; Haldemann, A. F. C.; Golombek, M. P.; Franklin, B. J.; Dohm, J. M.; Lias, J.

    2000-01-01

    The western hemisphere region of Mars has been the site of numerous scientific investigations regarding its tectonic evolution. For this region of Mars, the dominant tectonic region is the Tharsis province. Tharsis is characterized by an enormous system of radiating grabens and a circumferential system of wrinkle ridges. Past investigations of grabens associated with Tharsis have identified specific centers of tectonic activity. A recent structural analysis of the western hemisphere region of Mars which includes the Tharsis region, utilized 25,000 structures to determine the history of local and regional centers of tectonic activity based primarily on the spatial and temporal relationships of extensional features. This investigation revealed that Tharsis is more structurally complex (heterogeneous) than has been previously identified: it consists of numerous regional and local centers of tectonic activity (some are more dominant and/or more long lived than others). Here we use the same approach as Anderson et al. to determine whether the centers of tectonic activity that formed the extensional features also contributed to wrinkle ridge (compressional) formation.

  3. Local Nash Equilibrium in Social Networks

    PubMed Central

    Zhang, Yichao; Aziz-Alaoui, M. A.; Bertelle, Cyrille; Guan, Jihong

    2014-01-01

    Nash equilibrium is widely present in various social disputes. As of now, in structured static populations, such as social networks, regular, and random graphs, the discussions on Nash equilibrium are quite limited. In a relatively stable static gaming network, a rational individual has to comprehensively consider all his/her opponents' strategies before they adopt a unified strategy. In this scenario, a new strategy equilibrium emerges in the system. We define this equilibrium as a local Nash equilibrium. In this paper, we present an explicit definition of the local Nash equilibrium for the two-strategy games in structured populations. Based on the definition, we investigate the condition that a system reaches the evolutionary stable state when the individuals play the Prisoner's dilemma and snow-drift game. The local Nash equilibrium provides a way to judge whether a gaming structured population reaches the evolutionary stable state on one hand. On the other hand, it can be used to predict whether cooperators can survive in a system long before the system reaches its evolutionary stable state for the Prisoner's dilemma game. Our work therefore provides a theoretical framework for understanding the evolutionary stable state in the gaming populations with static structures. PMID:25169150

  4. How Do Doctors Diagnose NAFLD and NASH?

    MedlinePlus

    ... NAFLD and NASH, such as overweight or obesity insulin resistance high levels of triglycerides or abnormal levels of ... NASH, such as an enlarged liver signs of insulin resistance such as darkened skin patches over your knuckles, ...

  5. Morphology and channel evolution of small streams in the southern Blue Ridge mountains of western North Carolina

    Treesearch

    David Leigh

    2010-01-01

    Small streams are understudied in the Southern Blue Ridge Mountains, yet they constitute a huge portion of the drainage network and are relevant with respect to human impact on the landscape and stream restoration efforts. Morphologies of 44 streams (0.01 to 20 km2 watersheds) from western North Carolina are characterized and couched in the context of historical...

  6. The Hopeful Traveler Jay Bryan Nash.

    ERIC Educational Resources Information Center

    Jessup, Harvey M., Comp.

    This book is one of a series of publications preserving the best writing and speeches of outstanding leaders of the American Alliance for Health, Physical Education, Recreation and Dance. Jay Bryan Nash was one of the founders of the Alliance. The speeches and essays by Nash in this collection are, for the most part, appearing in published form…

  7. NARSTO SOS99NASH WIND PROFILER DATA

    Atmospheric Science Data Center

    2018-04-16

    NARSTO SOS99NASH WIND PROFILER DATA Project Title:  NARSTO ... Platform:  Ground Station Instrument:  Wind Profiler Location:  Nashville, Tennessee Spatial ... Data Guide Documents:  SOS99Nash Wind Profiler Guide Related Data:  Southern Oxidants ...

  8. Jay B. Nash.

    ERIC Educational Resources Information Center

    Jable, J. Thomas

    1985-01-01

    Jay B. Nash's accomplishments and professional service have long been recognized by physical educators. This article examines the major forces and events that made him one of the most important leaders in American physical education. (MT)

  9. Pre-Collegiate Teachers and Gary Nash

    ERIC Educational Resources Information Center

    Sesso, Gloria

    2009-01-01

    In this article, the author recalls the time she met Gary Nash at UCLA on July 13, 1992, when they began the work of creating the National Standards in History. Professor Nash was the leader in the development of the United States History Standards. In creating the Standards, they were to focus on Historical Thinking. They needed to organize the…

  10. Contrasting glacial/interglacial regimes in the western Arctic Ocean as exemplified by a sedimentary record from the Mendeleev Ridge

    USGS Publications Warehouse

    Polyak, L.; Curry, W.B.; Darby, D.A.; Bischof, J.; Cronin, T. M.

    2004-01-01

    Distinct cyclicity in lithology and microfaunal distribution in sediment cores from the Mendeleev Ridge in the western Arctic Ocean (water depths ca. 1. 5 km) reflects contrasting glacial/interglacial sedimentary patterns. We conclude that during major glaciations extremely thick pack ice or ice shelves covered the western Arctic Ocean and its circulation was restricted in comparison with interglacial, modern-type conditions. Glacier collapse events are marked in sediment cores by increased contents of ice-rafted debris, notably by spikes of detrital carbonates and iron oxide grains from the Canadian Arctic Archipelago. Composition of foraminiferal calcite ?? 18O and ??13C also shows strong cyclicity indicating changes in freshwater balance and/or ventilation rates of the Arctic Ocean. Light stable isotopic spikes characterize deglacial events such as the last deglaciation at ca. 12 14C kyr BP. The prolonged period with low ??18O and ??13C values and elevated contents of iron oxide grains from the Canadian Archipelago in the lower part of the Mendeleev Ridge record is interpreted to signify the pooling of freshwater in the Amerasia Basin, possibly in relation to an extended glaciation in arctic North America. Unique benthic foraminiferal events provide a means for an independent stratigraphic correlation of sedimentary records from the Mendeleev Ridge and other mid-depth locations throughout the Arctic Ocean such as the Northwind and Lomonosov Ridges. This correlation demonstrates the disparity of existing age models and underscores the need to establish a definitive chronostratigraphy for Arctic Ocean sediments. ?? 2003 Elsevier B.V. All rights reserved.

  11. Nash Social Welfare in Multiagent Resource Allocation

    NASA Astrophysics Data System (ADS)

    Ramezani, Sara; Endriss, Ulle

    We study different aspects of the multiagent resource allocation problem when the objective is to find an allocation that maximizes Nash social welfare, the product of the utilities of the individual agents. The Nash solution is an important welfare criterion that combines efficiency and fairness considerations. We show that the problem of finding an optimal outcome is NP-hard for a number of different languages for representing agent preferences; we establish new results regarding convergence to Nash-optimal outcomes in a distributed negotiation framework; and we design and test algorithms similar to those applied in combinatorial auctions for computing such an outcome directly.

  12. Pathophysiology of NASH: perspectives for a targeted treatment

    PubMed Central

    Marra, Fabio; Lotersztajn, Sophie

    2013-01-01

    Non alcoholic steatohepatitis (NASH) is the more severe form of nonalcoholic fatty liver disease. In NASH, fatty liver, hepatic inflammation, hepatocyte injury and fibrogenesis are associated, and thi condition may eventually lead to cirrhosis. Current treatment of NASH relies on the reduction of body weight and increase in physical activity, but there is no pharmacologic treatment approved as yet. Emerging data indicate that NASH progression results from parallel events originating from the liver as well as from the adipose tissue, the gut and the gastrointestinal tract. Thus, dysfunction of the adipose tissue through enhanced flow of free fatty acids and release of adipocytokines, and alterations in the gut microbiome generate proinflammatory signals that underly NASH progression. Additional ‘extrahepatic hits’ include dietary factors and gastrointestinal hormones. Within the liver, hepatocyte apoptosis, ER stress and oxidative stress are key contributors to hepatocellular injury. In addition, lipotoxic mediators and danger signals activate Kupffer cells which initiate and perpetuate the inflammatory response by releasing inflammatory mediators that contribute to inflammatory cell recruitment and development of fibrosis. Inflammatory and fibrogenic mediators include chemokines, the cannabinoid system, the inflammasome and activation of pattern-recognition receptors. Here we review the major mechanisms leading to appearance and progression of NASH, focusing on both extrahepatic signals and local inflammatory mechanisms, in an effort to identify the most promising molecular targets for the treatment of this condition. PMID:23394092

  13. Nash equilibrium and evolutionary dynamics in semifinalists' dilemma.

    PubMed

    Baek, Seung Ki; Son, Seung-Woo; Jeong, Hyeong-Chai

    2015-04-01

    We consider a tournament among four equally strong semifinalists. The players have to decide how much stamina to use in the semifinals, provided that the rest is available in the final and the third-place playoff. We investigate optimal strategies for allocating stamina to the successive matches when players' prizes (payoffs) are given according to the tournament results. From the basic assumption that the probability to win a match follows a nondecreasing function of stamina difference, we present symmetric Nash equilibria for general payoff structures. We find three different phases of the Nash equilibria in the payoff space. First, when the champion wins a much bigger payoff than the others, any pure strategy can constitute a Nash equilibrium as long as all four players adopt it in common. Second, when the first two places are much more valuable than the other two, the only Nash equilibrium is such that everyone uses a pure strategy investing all stamina in the semifinal. Third, when the payoff for last place is much smaller than the others, a Nash equilibrium is formed when every player adopts a mixed strategy of using all or none of its stamina in the semifinals. In a limiting case that only last place pays the penalty, this mixed-strategy profile can be proved to be a unique symmetric Nash equilibrium, at least when the winning probability follows a Heaviside step function. Moreover, by using this Heaviside step function, we study the tournament by using evolutionary replicator dynamics to obtain analytic solutions, which reproduces the corresponding Nash equilibria on the population level and gives information on dynamic aspects.

  14. Nash equilibrium and evolutionary dynamics in semifinalists' dilemma

    NASA Astrophysics Data System (ADS)

    Baek, Seung Ki; Son, Seung-Woo; Jeong, Hyeong-Chai

    2015-04-01

    We consider a tournament among four equally strong semifinalists. The players have to decide how much stamina to use in the semifinals, provided that the rest is available in the final and the third-place playoff. We investigate optimal strategies for allocating stamina to the successive matches when players' prizes (payoffs) are given according to the tournament results. From the basic assumption that the probability to win a match follows a nondecreasing function of stamina difference, we present symmetric Nash equilibria for general payoff structures. We find three different phases of the Nash equilibria in the payoff space. First, when the champion wins a much bigger payoff than the others, any pure strategy can constitute a Nash equilibrium as long as all four players adopt it in common. Second, when the first two places are much more valuable than the other two, the only Nash equilibrium is such that everyone uses a pure strategy investing all stamina in the semifinal. Third, when the payoff for last place is much smaller than the others, a Nash equilibrium is formed when every player adopts a mixed strategy of using all or none of its stamina in the semifinals. In a limiting case that only last place pays the penalty, this mixed-strategy profile can be proved to be a unique symmetric Nash equilibrium, at least when the winning probability follows a Heaviside step function. Moreover, by using this Heaviside step function, we study the tournament by using evolutionary replicator dynamics to obtain analytic solutions, which reproduces the corresponding Nash equilibria on the population level and gives information on dynamic aspects.

  15. Near-Nash targeting strategies for heterogeneous teams of autonomous combat vehicles

    NASA Astrophysics Data System (ADS)

    Galati, David G.; Simaan, Marwan A.

    2008-04-01

    Military strategists are currently seeking methodologies to control large numbers of autonomous assets. Automated planners based upon the Nash equilibrium concept in non-zero sum games are one option. Because such planners inherently consider possible adversarial actions, assets are able to adapt to, and to some extent predict, potential enemy actions. However, these planners must function properly both in cases in which a pure Nash strategy does not exist and in scenarios possessing multiple Nash equilibria. Another issue that needs to be overcome is the scalability of the Nash equilibrium. That is, as the dimensionality of the problem increases, the Nash strategies become unfeasible to compute using traditional methodologies. In this paper we introduce the concept of near-Nash strategies as a mechanism to overcome these difficulties. We then illustrate this concept by deriving the near-Nash strategies and using these strategies as the basis for an intelligent battle plan for heterogeneous teams of autonomous combat air vehicles in the Multi-Team Dynamic Weapon Target Assignment model.

  16. Quantum Nash Equilibria and Quantum Computing

    NASA Astrophysics Data System (ADS)

    Fellman, Philip Vos; Post, Jonathan Vos

    In 2004, At the Fifth International Conference on Complex Systems, we drew attention to some remarkable findings by researchers at the Santa Fe Institute (Sato, Farmer and Akiyama, 2001) about hitherto unsuspected complexity in the Nash Equilibrium. As we progressed from these findings about heteroclinic Hamiltonians and chaotic transients hidden within the learning patterns of the simple rock-paper-scissors game to some related findings on the theory of quantum computing, one of the arguments we put forward was just as in the late 1990's a number of new Nash equilibria were discovered in simple bi-matrix games (Shubik and Quint, 1996; Von Stengel, 1997, 2000; and McLennan and Park, 1999) we would begin to see new Nash equilibria discovered as the result of quantum computation. While actual quantum computers remain rather primitive (Toibman, 2004), and the theory of quantum computation seems to be advancing perhaps a bit more slowly than originally expected, there have, nonetheless, been a number of advances in computation and some more radical advances in an allied field, quantum game theory (Huberman and Hogg, 2004) which are quite significant. In the course of this paper we will review a few of these discoveries and illustrate some of the characteristics of these new "Quantum Nash Equilibria". The full text of this research can be found at http://necsi.org/events/iccs6/viewpaper.php?id-234

  17. Transport of Iceland-Scotland Overflow waters in the Deep Western Boundary Current along the Reykjanes Ridge

    NASA Astrophysics Data System (ADS)

    Johns, William; Houk, Adam; Koman, Greg; Zou, Sijia; Lozier, Susan

    2017-04-01

    Since 2014, an array of current meters deployed as part of the OSNAP trans-basin observing system has provided new measurements of the southward flow of Iceland-Scotland Overflow water (ISOW) along the eastern flank of the Reykjanes Ridge in the Iceland Basin. The location of the array, near 58-59°N, captures the ISOW Deep Western Boundary Current at the farthest downstream location in the Iceland Basin before significant amounts of ISOW can flow into the Irminger Basin through deep fractures in the Reykjanes Ridge. The transport of the ISOW DWBC at this location - based on the first two years of OSNAP observations (July 2014 to July 2016) - is 5.8 ± 0.9 Sv for σθ >27.8. Most of this transport is carried in a main branch of the DWBC along the upper ridge crest in depths from 1400-2200 m, while a secondary branch in depths of 2400-2700 m along the lower ridge crest carries about 1 Sv. The branching of the DWBC at this location is consistent with numerical model results and is caused by an upstream topographic plateau at mid-depths along the ridge crest. The T-S properties of the flow and backward trajectories computed from high-resolution FLAME and VIKING models confirm that the flow in both branches is derived from ISOW and its entrainment products. The transport of the ISOW plume varies over a considerable range, from about 2-10 Sv on weekly to monthly time scales (std. dev. = 2.4 Sv); however the mean currents from two individual year-long deployments are very similar and indicate a robust mean flow structure. The observed ISOW transport at this location is larger by almost 2 Sv than previous values obtained (mostly) farther north in the Iceland Basin, suggesting that additional entrainment into the ISOW plume occurs as it approaches the southern tip of the Reykjanes Ridge.

  18. Implications for crustal accretion at fast spreading ridges from observations in Jurassic oceanic crust in the western Pacific

    NASA Astrophysics Data System (ADS)

    Pockalny, Robert A.; Larson, Roger L.

    2003-01-01

    Downhole logging data and basement stratigraphy interpretations are used to determine the spreading environment and crustal accretion history of the ocean basement cored at ODP Hole 801C located in the Jurassic Magnetic Quiet Zone of the western Pacific. High-resolution microresistivity data obtained with the Formation MicroScanner are used to measure the dip of the extrusive layers and indicate a 10°-30° increase in dip down the drill hole with lava flow contacts dipping back toward the original ridge axis. This structural pattern and the high proportion of massive flows relative to pillow units are consistent with prevailing crustal accretion models proposed for faster spreading ridges (e.g., >60 km/m.y., full-rate). A detailed analysis of the age data, basement lithology, related geochemistry, and structural attitudes suggest the shallowest 100 m of the drilled section (e.g., Sequences I-III) were emplaced just off the ridge (Sequence III) or significantly farther off-axis up to 5-15 m.y. later (Sequences I and II). The remainder of the drilled section (e.g., Sequences IV-VIII) has geochemical, lithological and physical trends that are assumed to be representative of crust created at faster spreading ridges. The pattern of dipping lava flow contacts from this deeper section of the drill hole suggests lava flows emanating from the ridge axis are limited to 1-2 km off-axis. Our results suggest ocean crust drilled at Hole 801C was created at faster spreading rates; however, caution should be used when incorporating Sequences I-III into geochemical reference sections for faster spreading ridges.

  19. The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α.

    PubMed

    Ren, Tingting; Zhu, Juanjuan; Zhu, Lili; Cheng, Mingliang

    2017-02-27

    Nonalcoholic steatohepatitis (NASH) is liver inflammation and a major threat to public health. Several pharmaceutical agents have been used for NASH therapy but their high-rate side effects limit the use. Blueberry juice and probiotics (BP) have anti-inflammation and antibacterial properties, and may be potential candidates for NASH therapy. To understand the molecular mechanism, Sprague Dawley rats were used to create NASH models and received different treatments. Liver tissues were examined using HE (hematoxylin and eosin) and ORO (Oil Red O) stain, and serum biochemical indices were measured. The levels of peroxisome proliferators-activated receptor (PPAR)-α, sterol regulatory element binding protein-1c (SREBP-1c), Patatin-like phospholipase domain-containing protein 3 (PNPLA-3), inflammatory cytokines and apoptosis biomarkers in liver tissues were measured by qRT-PCR and Western blot. HE and ORO analysis indicated that the hepatocytes were seriously damaged with more and larger lipid droplets in NASH models while BP reduced the number and size of lipid droplets ( p < 0.05). Meanwhile, BP increased the levels of SOD (superoxide dismutase), GSH (reduced glutathione) and HDL-C (high-density lipoprotein cholesterol), and reduced the levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), TG (triglycerides), LDL-C (low-density lipoprotein cholesterol) and MDA (malondialdehyde) in NASH models ( p < 0.05). BP increased the level of PPAR-α (Peroxisome proliferator-activated receptor α), and reduced the levels of SREBP-1c (sterol regulatory element binding protein-1c) and PNPLA-3 (Patatin-like phospholipase domain-containing protein 3) ( p < 0.05). BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-α (Tumor necrosis factor α), caspase-3 and Bcl-2 in NASH models. Furthermore, PPAR-α inhibitor increased the level of SREBP-1c and PNPLA-3. Therefore, BP prevents NASH progression by affecting SREBP-1c/PNPLA-3

  20. Quantum gambling based on Nash-equilibrium

    NASA Astrophysics Data System (ADS)

    Zhang, Pei; Zhou, Xiao-Qi; Wang, Yun-Long; Liu, Bi-Heng; Shadbolt, Pete; Zhang, Yong-Sheng; Gao, Hong; Li, Fu-Li; O'Brien, Jeremy L.

    2017-06-01

    The problem of establishing a fair bet between spatially separated gambler and casino can only be solved in the classical regime by relying on a trusted third party. By combining Nash-equilibrium theory with quantum game theory, we show that a secure, remote, two-party game can be played using a quantum gambling machine which has no classical counterpart. Specifically, by modifying the Nash-equilibrium point we can construct games with arbitrary amount of bias, including a game that is demonstrably fair to both parties. We also report a proof-of-principle experimental demonstration using linear optics.

  1. Ultramafic rocks of the western Idaho suture zone: Asbestos Peak and Misery Ridge

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Godchaux, M.M.; Bonnichsen, B.

    1993-04-01

    The Western Idaho Ultramafic Belt extends northward from the town of Weiser to the northern end of Dworshak Reservoir; in its northern portion most of the ultramafic bodies are localized along the suture zone where the Mesozoic oceanic accreted terranes meet the continental craton. Of the twenty bodies investigated, all are small, all are in fault contact with their metavolcanic and metasedimentary host rocks, all have been metamorphosed, and all display deformational fabrics in at least some portion of the outcrop area, suggesting that deformation continued after peak metamorphism. The degree of metamorphism ranges from incipient serpentinization to attainment ofmore » equilibrium in the upper amphibolite facies. Some bodies have been intruded by granitic dikes or pegmatite veins after emplacement, and have locally undergone contact metasomatism. Two particularly complex bodies, Asbestos Peak and Misery Ridge, were chosen for detailed petrographic and chemical study. Asbestos Peak is composed mostly of decussate anthophyllite-talc rock containing isolated patches of harzburgite protolith, and has blackwall border zones. Misery Ridge is composed mostly of coarse-grained sheared tremolite-talc schist without remnant protolith, and lacks true blackwall zones. Both bodies exhibit an unusual and enigmatic hornblende-poikiloblastic garnet-green spinel-skeletal ilmenite assemblage, present in some places as well-defined border zones and in other places as cross-cutting bodies.« less

  2. Non-alcoholic steatohepatitis (NASH) in patients with polycystic ovarian syndrome (PCOS).

    PubMed

    Hossain, Noreen; Stepanova, Maria; Afendy, Arian; Nader, Fatema; Younossi, Youssef; Rafiq, Nila; Goodman, Zachary; Younossi, Zobair M

    2011-04-01

    Both non-alcoholic steatohepatitis (NASH) and polycystic ovary syndrome (PCOS) are associated with metabolic syndrome (MS) and insulin resistance (IR). Except for a few case reports, there are no systematic assessments of NASH in PCOS patients. To determine the prevalence of NASH and independent factors associated with NASH in a cohort of patients with documented PCOS. Patients with established diagnosis of PCOS and matched controls (matched for gender, age, and body mass index (BMI)) were included in the study. Causes of other liver diseases were systematically excluded by clinical and laboratory tests. Excessive alcohol use was defined as alcohol consumption of greater than 10 g/day. All liver biopsies were read by a single pathologist blinded to the clinical data. Histologic NASH was defined as steatosis with lobular inflammation and ballooning degeneration of hepatocytes with or without Mallory-Denk bodies or pericellular fibrosis. Univariate and multivariate analyses with logistic regression were performed to compare PCOS to matched controls. Sixty-six patients were included in the study (34 PCOS and 32 matched controls). Of PCOS patients, 73% had a liver biopsy while 78% of the matched controls had a liver biopsy. In comparing PCOS patients to the matched controls, clinical (BMI, waist circumference, type 2 diabetes, MS, or its components, any alcohol consumption in the prior year, ethnic background, age, gender, etc.) and laboratory data (aminotransferases, ferritin, glucose, etc.) were not significantly different (p > 0.05). However, PCOS patients tended to have more histologic NASH on their liver biopsies (44.0% vs. 20.8%, p = 0.08). Independent predictors of histologic NASH in PCOS patients were elevated aspartate aminotransferase (AST), high triglycerides and small amounts of alcohol consumption (p = 0.019, 10-fold cross-validated AUC = 0.80, 95% CI = 0.56-0.94). Although about half of PCOS patients did not report any alcohol consumption, 50% did report

  3. Lithospheric structure of a nascent spreading ridge inferred from gravity data: The western Gulf of Aden

    NASA Astrophysics Data System (ADS)

    HéBert, HéLèNe; Deplus, Christine; Huchon, Philippe; Khanbari, Khaled; Audin, Laurence

    2001-11-01

    The Aden spreading ridge (Somalia/Arabia plate boundary) does not connect directly to the Red Sea spreading ridge. It propagates toward the East African Rift through the Afar depression, where the presence of a hot spot has been postulated from seismological and geochemical evidence. The spreading direction (N37°E) is highly oblique to the overall trend (N90°E) of the ridge. We present and interpret new geophysical data gathered during the Tadjouraden cruise (R/V L'Atalante, 1995) in the Gulf of Aden west of 46°E. These data allow us to study the propagation of the ridge toward the Afar and to discuss the processes of the seafloor spreading initiation. We determine the lithospheric structure of the ridge using gravity data gathered during the cruise with the constraint of available refraction data. A striking Bouguer anomaly gradient together with the identification of magnetic anomalies defines the geographical extent of oceanic crust. The inversion of the Bouguer anomaly is performed in terms of variations of crustal thickness only and then discussed with respect to the expected thermal structure of the mantle lithosphere, which should depend not only on the seafloor spreading but also on the hot spot beneath East Africa. Our results allow us to define three distinct lithospheric domains in the western Gulf of Aden. East of 44°45'E the lithosphere displays an oceanic character (thermal subsidence recorded for the last 10 Ma and constant crustal thickness). Between 43°30'E and 44°10'E the lithosphere is of continental type but locally thinned beneath the axial valley. The central domain defined between 44°10'E and 44°45'E is characterized by a transitional lithosphere which can be seen as a stretched continental crust where thick blocks are mixed with thinned crust; it displays en echelon basins that are better interpreted as extension cells rather than accretion cells.

  4. Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice

    PubMed Central

    Lytle, Kelli A.; Wong, Carmen P.

    2017-01-01

    Background Nonalcoholic fatty liver disease (NAFLD) is a major public health concern in western societies. Nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD, is characterized by hepatic steatosis, inflammation, oxidative stress and fibrosis. NASH is a risk factor for cirrhosis and hepatocellular carcinoma. NASH is predicted to be the leading cause of liver transplants by 2020. Despite this growing public health concern, there remain no Food and Drug Administration (FDA) approved NASH treatments. Using Ldlr -/- mice as a preclinical model of western diet (WD)-induced NASH, we previously established that dietary supplementation with docosahexaenoic acid (DHA, 22:6,ω3) attenuated WD-induced NASH in a prevention study. Herein, we evaluated the capacity of DHA supplementation of the WD and a low fat diet to fully reverse NASH in mice with pre-existing disease. Methods Ldlr -/- mice fed the WD for 22 wks developed metabolic syndrome (MetS) and a severe NASH phenotype, including obesity, dyslipidemia, hyperglycemia, hepatic steatosis, inflammation, fibrosis and low hepatic polyunsaturated fatty acid (PUFA) content. These mice were randomized to 5 groups: a baseline group (WDB, sacrificed at 22 wks) and 4 treatments: 1) WD + olive oil (WDO); 2) WD + DHA (WDD); 3) returned to chow + olive oil (WDChO); or 4) returned to chow + DHA (WDChD). The four treatment groups were maintained on their respective diets for 8 wks. An additional group was maintained on standard laboratory chow (Reference Diet, RD) for the 30-wk duration of the study. Results When compared to the WDB group, the WDO group displayed increased hepatic expression of genes linked to inflammation (Opn, Il1rn, Gdf15), hepatic fibrosis (collagen staining, Col1A1, Thbs2, Lox) reflecting disease progression. Mice in the WDD group, in contrast, had increased hepatic C20-22 ω3 PUFA and no evidence of NASH progression. MetS and NASH markers in the WDChO or WDChD groups were significantly attenuated

  5. Development of a novel diagnostic algorithm to predict NASH in HCV-positive patients.

    PubMed

    Gallotta, Andrea; Paneghetti, Laura; Mrázová, Viera; Bednárová, Adriana; Kružlicová, Dáša; Frecer, Vladimir; Miertus, Stanislav; Biasiolo, Alessandra; Martini, Andrea; Pontisso, Patrizia; Fassina, Giorgio

    2018-05-01

    Non-alcoholic steato-hepatitis (NASH) is a severe disease characterised by liver inflammation and progressive hepatic fibrosis, which may progress to cirrhosis and hepatocellular carcinoma. Clinical evidence suggests that in hepatitis C virus patients steatosis and NASH are associated with faster fibrosis progression and hepatocellular carcinoma. A safe and reliable non-invasive diagnostic method to detect NASH at its early stages is still needed to prevent progression of the disease. We prospectively enrolled 91 hepatitis C virus-positive patients with histologically proven chronic liver disease: 77 patients were included in our study; of these, 10 had NASH. For each patient, various clinical and serological variables were collected. Different algorithms combining squamous cell carcinoma antigen-immunoglobulin-M (SCCA-IgM) levels with other common clinical data were created to provide the probability of having NASH. Our analysis revealed a statistically significant correlation between the histological presence of NASH and SCCA-IgM, insulin, homeostasis model assessment, haemoglobin, high-density lipoprotein and ferritin levels, and smoke. Compared to the use of a single marker, algorithms that combined four, six or seven variables identified NASH with higher accuracy. The best diagnostic performance was obtained with the logistic regression combination, which included all seven variables correlated with NASH. The combination of SCCA-IgM with common clinical data shows promising diagnostic performance for the detection of NASH in hepatitis C virus patients.

  6. A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH).

    PubMed

    Younossi, Zobair M; Jarrar, Mohammed; Nugent, Clare; Randhawa, Manpreet; Afendy, Mariam; Stepanova, Maria; Rafiq, Nila; Goodman, Zachary; Chandhoke, Vikas; Baranova, Ancha

    2008-11-01

    Within the spectrum of nonalcoholic fatty liver disease (NAFLD), only patients with nonalcoholic steatohepatitis (NASH) show convincing evidence for progression. To date, liver biopsy remains the gold standard for the diagnosis of NASH; however, liver biopsy is expensive and associated with a small risk, emphasizing the urgent need for noninvasive diagnostic biomarkers. Recent findings suggest a role for apoptosis and adipocytokines in the pathogenesis of NASH. The aim of this study was to develop a noninvasive diagnostic biomarker for NASH. The study included 101 patients with liver biopsies who were tested with enzyme-linked immunosorbent assay (ELISA)-based assays. Of these, 69 were included in the biomarker development set and 32 were included in the biomarker validation set. Clinical data and serum samples were collected at the time of biopsy. Fasting serum samples were assayed for adiponectin, resistin, insulin, glucose, TNF-alpha, IL-6, IL-8, cytokeratin CK-18 (M65 antigen), and caspase-cleaved CK-18 (M30 antigen). Data analysis revealed that the levels of M30 antigen (cleaved CK-18) predicted histological NASH with 70% sensitivity and 83.7% specificity and area under the curve (AUC) = 0.711, p < 10(-4), whereas the predictive value of the levels of intact CK-18 (M65) was higher (63.6% sensitivity and 89.4% specificity and AUC = 0.814, p < 10(-4)). Histological NASH could be predicted by a combination of Cleaved CK-18, a product of the subtraction of Cleaved CK-18 level from intact CK-18 level, serum adiponectin, and serum resistin with a sensitivity of 95.45% sensitivity, specificity of 70.21%, and AUC of 0.908 (p < 10(-4)). Blinded validation of this model confirmed its reliability for separating NASH from simple steatosis. Four ELISA-based tests were combined to form a simple diagnostic biomarker for NASH.

  7. The Nash Equilibrium Revisited: Chaos and Complexity Hidden in Simplicity

    NASA Astrophysics Data System (ADS)

    Fellman, Philip V.

    The Nash Equilibrium is a much discussed, deceptively complex, method for the analysis of non-cooperative games (McLennan and Berg, 2005). If one reads many of the commonly available definitions the description of the Nash Equilibrium is deceptively simple in appearance. Modern research has discovered a number of new and important complex properties of the Nash Equilibrium, some of which remain as contemporary conundrums of extraordinary difficulty and complexity (Quint and Shubik, 1997). Among the recently discovered features which the Nash Equilibrium exhibits under various conditions are heteroclinic Hamiltonian dynamics, a very complex asymptotic structure in the context of two-player bi-matrix games and a number of computationally complex or computationally intractable features in other settings (Sato, Akiyama and Farmer, 2002). This paper reviews those findings and then suggests how they may inform various market prediction strategies.

  8. The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α

    PubMed Central

    Ren, Tingting; Zhu, Juanjuan; Zhu, Lili; Cheng, Mingliang

    2017-01-01

    Nonalcoholic steatohepatitis (NASH) is liver inflammation and a major threat to public health. Several pharmaceutical agents have been used for NASH therapy but their high-rate side effects limit the use. Blueberry juice and probiotics (BP) have anti-inflammation and antibacterial properties, and may be potential candidates for NASH therapy. To understand the molecular mechanism, Sprague Dawley rats were used to create NASH models and received different treatments. Liver tissues were examined using HE (hematoxylin and eosin) and ORO (Oil Red O) stain, and serum biochemical indices were measured. The levels of peroxisome proliferators-activated receptor (PPAR)-α, sterol regulatory element binding protein-1c (SREBP-1c), Patatin-like phospholipase domain-containing protein 3 (PNPLA-3), inflammatory cytokines and apoptosis biomarkers in liver tissues were measured by qRT-PCR and Western blot. HE and ORO analysis indicated that the hepatocytes were seriously damaged with more and larger lipid droplets in NASH models while BP reduced the number and size of lipid droplets (p < 0.05). Meanwhile, BP increased the levels of SOD (superoxide dismutase), GSH (reduced glutathione) and HDL-C (high-density lipoprotein cholesterol), and reduced the levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), TG (triglycerides), LDL-C (low-density lipoprotein cholesterol) and MDA (malondialdehyde) in NASH models (p < 0.05). BP increased the level of PPAR-α (Peroxisome proliferator-activated receptor α), and reduced the levels of SREBP-1c (sterol regulatory element binding protein-1c) and PNPLA-3 (Patatin-like phospholipase domain-containing protein 3) (p < 0.05). BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-α (Tumor necrosis factor α), caspase-3 and Bcl-2 in NASH models. Furthermore, PPAR-α inhibitor increased the level of SREBP-1c and PNPLA-3. Therefore, BP prevents NASH progression by affecting SREBP-1c/PNPLA-3 pathway

  9. Morphology and segmentation of the western Galápagos Spreading Center, 90.5°-98°W: Plume-ridge interaction at an intermediate spreading ridge

    NASA Astrophysics Data System (ADS)

    Sinton, John; Detrick, Robert; Canales, J. Pablo; Ito, Garrett; Behn, Mark

    2003-12-01

    Complete multibeam bathymetric coverage of the western Galápagos Spreading Center (GSC) between 90.5°W and 98°W reveals the fine-scale morphology, segmentation and influence of the Galápagos hot spot on this intermediate spreading ridge. The western GSC comprises three morphologically defined provinces: A Western Province, located farthest from the Galápagos hot spot west of 95°30'W, is characterized by an axial deep, rift valley morphology with individual, overlapping, E-W striking segments separated by non-transform offsets; A Middle Province, between the propagating rift tips at 93°15'W and 95°30'W, with transitional axial morphology strikes ˜276°; An Eastern Province, closest to the Galápagos hot spot between the ˜90°50'W Galápagos Transform and 93°15'W, with an axial high morphology generally less than 1800 m deep, strikes ˜280°. At a finer scale, the axial region consists of 32 individual segments defined on the basis of smaller, mainly <2 km, offsets. These offsets mainly step left in the Western and Middle Provinces, and right in the Eastern Province. Glass compositions indicate that the GSC is segmented magmatically into 8 broad regions, with Mg # generally decreasing to the west within each region. Striking differences in bathymetric and lava fractionation patterns between the propagating rifts with tips at 93°15'W and 95°30'W reflect lower overall magma supply and larger offset distance at the latter. The structure of the Eastern Province is complicated by the intersection of a series of volcanic lineaments that appear to radiate away from a point located on the northern edge of the Galápagos platform, close to the southern limit of the Galápagos Fracture Zone. Where these lineaments intersect the GSC, the ridge axis is displaced to the south through a series of overlapping spreading centers (OSCs); abandoned OSC limbs lie even farther south. We propose that southward displacement of the axis is promoted during intermittent times of

  10. High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine.

    PubMed

    Panasevich, M R; Meers, G M; Linden, M A; Booth, F W; Perfield, J W; Fritsche, K L; Wankhade, Umesh D; Chintapalli, Sree V; Shankar, K; Ibdah, J A; Rector, R S

    2018-01-01

    Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal models. Here, we examined the effects of high-fat, high-fructose corn syrup, high-cholesterol Western-style diet (WD)-induced obesity on NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. Juvenile female Ossabaw swine (5 wk old) were fed WD (43.0% fat; 17.8% high-fructose corn syrup; 2% cholesterol) or low-fat diet (CON/lean; 10.5% fat) for 16 wk ( n = 6 each) or 36 wk ( n = 4 each). WD-fed pigs developed obesity, dyslipidemia, and systemic insulin resistance compared with CON pigs. In addition, obese WD-fed pigs developed severe NASH, with hepatic steatosis, hepatocyte ballooning, inflammatory cell infiltration, and fibrosis after 16 wk, with further exacerbation of histological inflammation and fibrosis after 36 wk of WD feeding. WD feeding also resulted in robust cecal microbiota changes including increased relative abundances of families and genera in Proteobacteria ( P < 0.05) (i.e., Enterobacteriaceae, Succinivibrionaceae, and Succinivibrio) and LPS-containing Desulfovibrionaceae and Desulfovibrio and a greater ( P < 0.05) predicted microbial metabolic function for LPS biosynthesis, LPS biosynthesis proteins, and peptidoglycan synthesis compared with CON-fed pigs. Overall, juvenile Ossabaw swine fed a high-fat, high-fructose, high-cholesterol diet develop obesity and severe microbiota dysbiosis with a proinflammatory signature and a NASH phenotype directly relevant to the pediatric/adolescent and young adult population.

  11. Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients

    PubMed Central

    Losekann, Alexandre; Weston, Antonio C.; de Mattos, Angelo A.; Tovo, Cristiane V.; de Carli, Luis A.; Espindola, Marilia B.; Pioner, Sergio R.; Coral, Gabriela P.

    2015-01-01

    The aim was to investigate the prevalence of non-alcoholic steatohepatitis (NASH) and risk factors for hepatic fibrosis in morbidly obese patients submitted to bariatric surgery. This retrospective study recruited all patients submitted to bariatric surgery from January 2007 to December 2012 at a reference attendance center of Southern Brazil. Clinical and biochemical data were studied as a function of the histological findings of liver biopsies done during the surgery. Steatosis was present in 226 (90.4%) and NASH in 176 (70.4%) cases. The diagnosis of cirrhosis was established in four cases (1.6%) and fibrosis in 108 (43.2%). Risk factors associated with NASH at multivariate analysis were alanine aminotransferase (ALT) >1.5 times the upper limit of normal (ULN); glucose ≥ 126 mg/dL and triglycerides ≥ 150 mg/dL. All patients with ALT ≥1.5 times the ULN had NASH. When the presence of fibrosis was analyzed, ALT > 1.5 times the ULN and triglycerides ≥ 150 mg/dL were risk factors, furthermore, there was an increase of 1% in the prevalence of fibrosis for each year of age increase. Not only steatosis, but NASH is a frequent finding in MO patients. In the present study, ALT ≥ 1.5 times the ULN identifies all patients with NASH, this finding needs to be further validated in other studies. Moreover, the presence of fibrosis was associated with ALT, triglycerides and age, identifying a subset of patients with more severe disease. PMID:26512661

  12. Controversies in the Diagnosis and Management of NAFLD and NASH.

    PubMed

    Rinella, Mary E; Loomba, Rohit; Caldwell, Stephen H; Kowdley, Kris; Charlton, Michael; Tetri, Brent; Harrison, Stephen A

    2014-04-01

    Nonalcoholic fatty liver disease (NAFLD) is recognized as the most common cause of chronic liver disease in the United States. Nonalcoholic steatohepatitis (NASH) occurs in a subset of patients with NAFLD and is characterized by the presence of hepa-tocellular injury, which is progressive in a substantial proportion of cases and can lead to cirrhosis and all of its complications. Although the diagnosis of NAFLD can be made through imaging studies or liver biopsy, the diagnosis of NASH still requires histologic confirmation. Liver biopsy should be performed in the presence of risk factors for advanced disease. Measures aimed at promoting weight loss, a healthier lifestyle, and optimization of metabolic risk factors remain the cornerstone of management of NAFLD. Therapeutic agents that are presently considered the most promising in NAFLD are effective in less than 50% of patients. Among patients with biopsy-proven NASH, treatment with pharmacologic agents should be considered; however, the role of specific agents in NASH still needs further study. Despite a wealth of research over the past 15 years, many controversies remain with respect to the diagnosis and management of NAFLD and NASH as well as the influence of alcohol on liver disease progression in these patients.

  13. Deformation patterns in the southwestern part of the Mediterranean Ridge (South Matapan Trench, Western Greece)

    NASA Astrophysics Data System (ADS)

    Andronikidis, Nikolaos; Kokinou, Eleni; Vafidis, Antonios; Kamberis, Evangelos; Manoutsoglou, Emmanouil

    2017-12-01

    Seismic reflection data and bathymetry analyses, together with geological information, are combined in the present work to identify seabed structural deformation and crustal structure in the Western Mediterranean Ridge (the backstop and the South Matapan Trench). As a first step, we apply bathymetric data and state of art methods of pattern recognition to automatically detect seabed lineaments, which are possibly related to the presence of tectonic structures (faults). The resulting pattern is tied to seismic reflection data, further assisting in the construction of a stratigraphic and structural model for this part of the Mediterranean Ridge. Structural elements and stratigraphic units in the final model are estimated based on: (a) the detected lineaments on the seabed, (b) the distribution of the interval velocities and the presence of velocity inversions, (c) the continuity and the amplitudes of the seismic reflections, the seismic structure of the units and (d) well and stratigraphic data as well as the main tectonic structures from the nearest onshore areas. Seabed morphology in the study area is probably related with the past and recent tectonics movements that result from African and European plates' convergence. Backthrusts and reverse faults, flower structures and deep normal faults are among the most important extensional/compressional structures interpreted in the study area.

  14. Nash Receives 2004 David Perlman Award for Excellence in Science Writing

    NASA Astrophysics Data System (ADS)

    Elmer-DeWitt, Philip; Nash, J. Madeleine

    2004-07-01

    J. Madeleine Nash received the David Perlman Award for Excellence in Science Writing at the AGU Joint Assembly Honors Ceremony, which was held on 19 May 2004, in Montreal, Canada. Nash was honored for ``Fireproofing the Forests,'' an article that appeared in the 18 August 2003 edition of Time Magazine. ``It is an honor to present AGU's 2004 David Perlman Award to Madeleine Nash, a senior contributor to Time Magazine and, if I may say so, one of the great science writers of her generation.''

  15. Surface radiological investigations at White Wing Scrap Yard, Oak Ridge Reservation, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Williams, J.K.; Rodriguez, R.E.; Uziel, M.S.

    1991-09-01

    A surface radiological scoping survey of accessible areas at the White Wing Scrap Yard (Waste Area Grouping 11 (WAG 11)) was conducted intermittently from December 1989 through July 1991 by members of the Measurement Applications and Development Group, Health and Safety Research Division, Oak Ridge National Laboratory (ORNL) at the request of Environmental Restoration Program personnel at ORNL. The White Wing Scrap Yard is an estimated 30-acre, predominately wooded area located on the western edge of East Fork Ridge in the McNew Hollow area on the US Department of Energy's Oak Ridge Reservation. The scrap yard was formerly used formore » aboveground storage of contaminated material (e.g., steel tanks, metal, glass, concrete, and miscellaneous industrial trash) from the Oak Ridge K-25 Site, Oak Ridge Y-12 Plant, and ORNL. The purposes of this cursory investigation were (1) to provide an updated contamination status of the site by locating and interpreting the presence, nature, and extent of surface radiological contamination and (2) to provide a basis for the formulation of interim corrective action to limit human exposures to radioactivity and minimize the potential for contaminant dispersion. 13 refs., 17 figs., 5 tabs.« less

  16. Ridge Tectonics, Magma Supply, and Ridge-Hotpot Interaction at the Eastern End of the Australian-Antarctic Ridge

    NASA Astrophysics Data System (ADS)

    Kim, S.; Lin, J.; Park, S.; Choi, H.; Lee, S.

    2013-12-01

    the Balleny hotpot is not dominant in the axial morphology of the AAR super-segment. The axial topography of this super-segment exhibits a sharp transition from axial highs at the western end to rift valleys at the eastern end, with regions of axial highs being associated with more magma supply as indicated by more negative RMBA. The eastern AAR will be further compared with other intermediate fast spreading ridges, such as the Juan de Fuca Ridge, Galápagos Spreading Center, and Southeast Indian Ridge west of the Australian-Antarctic Discordance, to better understand the influence of ridge-hotspot interaction on ridge magma supply and tectonics.

  17. East Pacific Rise at lat 19°S: Evidence for a recent ridge jump

    NASA Astrophysics Data System (ADS)

    Morton, Janet L.; Ballard, Robert D.

    1986-02-01

    A detailed ANGUS (Acoustically Navigated Geological Undersea Surveyor) photographic and bathymetric survey of the East Pacific Rise (EPR) near lat 19°S reveals a small jump of the ridge axis to the west. The axial block in this region consists of two parallel ridges 3 km apart and separated by a 200-m-deep valley. South of lat 19°06‧S the plate boundary is a single, narrow (<1 km) ridge. The eastern ridge near lat 19°S is shallower than the western ridge and is morphologically a continuation of the narrow, active ridge axis to the south. ANGUS photographs along both ridges and in the intervening valley, however, show that the western ridge is the currently active plate boundary. We suggest that spreading shifted westward from the eastern ridge to its present position within the past 40 000 yr. The EPR in the general region has been characterized by asymmetric spreading for the past 2.4 m.y. The sense of the ridge jump near lat 19°S is consistent with the asymmetric spreading, which could have been produced by a series of such jumps.

  18. Uniqueness of Nash equilibrium in vaccination games.

    PubMed

    Bai, Fan

    2016-12-01

    One crucial condition for the uniqueness of Nash equilibrium set in vaccination games is that the attack ratio monotonically decreases as the vaccine coverage level increasing. We consider several deterministic vaccination models in homogeneous mixing population and in heterogeneous mixing population. Based on the final size relations obtained from the deterministic epidemic models, we prove that the attack ratios can be expressed in terms of the vaccine coverage levels, and also prove that the attack ratios are decreasing functions of vaccine coverage levels. Some thresholds are presented, which depend on the vaccine efficacy. It is proved that for vaccination games in homogeneous mixing population, there is a unique Nash equilibrium for each game.

  19. Mixed Nash equilibria in Eisert-Lewenstein-Wilkens (ELW) games

    NASA Astrophysics Data System (ADS)

    Bolonek-Lasoń, Katarzyna; Kosiński, Piotr

    2017-01-01

    The classification of all mixed Nash equilibria for the original ELW game is presented. It is based on the quaternionic form of the game proposed by Landsburg (Proc. Am. Math. Soc. 139 (2011), 4423; Rochester Working Paper No 524 (2006); Wiley Encyclopedia of Operations Research and Management Science (Wiley and Sons, New York, (2011)). This approach allows to reduce the problem of finding the Nash equilibria to relatively simple analysis of the extrema of certain quadratic forms.

  20. A Tribute to Gary Nash

    ERIC Educational Resources Information Center

    Jason-Fives, Alli

    2009-01-01

    In this article, the author gives tribute to Gary Nash, a brilliant scholar, an award-winning professor, a prolific writer, a true humanitarian, and a revered historian. She honors him for his work with public school teachers. He has provided the educational support, encouragement, and motivation behind the importance of teaching history. Here,…

  1. Dynamics of Productivity-Related Oxygen Minimum Zone along the Shirshov Ridge, Western Bering Sea, during the Last Glacial Termination

    NASA Astrophysics Data System (ADS)

    Ovsepyan, E.; Ivanova, E. V.; Tiedemann, R.

    2017-12-01

    Seasonally sea-ice covered Bering Sea is known to be a sensitive region to study rapid climatic oscillations. Based on benthic (BF) and planktic (PF) foraminiferal data from two sediment cores SO201-2-85KL (85KL, w.d. 968 m) and SO201-2-77KL (77KL, w.d. 2163 m) we reconstruct variations in intensity of oxygen minimum zone (OMZ) and its relation to sea-surface bioproductivity in the central and southern parts of the Shirshov Ridge, western Bering Sea, during the Termination I. A prevalence of suboxic BF group (Kaiho, 1994) in both cores mirrors moderately oxygenated intermediate and deep waters during LGM-Heinrich I interval. Rapid increase in percentages of dysoxic group is registered in the core 77KL at the onset of Bølling/Allerød. This implies that relatively low-oxygen conditions developed at 2 km water depths in the southwestern Bering Sea, but occurrence (20-30%) of suboxic group suggests that oxygen depletion was not dramatic. Simultaneous spikes of high-productivity species point to a bioproductivity rise above the southern part of the ridge. Increase in bioproductivity and decrease in oxygen content are detected 0.9 kyr later above the central part of Shirshov Ridge than above the southern one. This delay might reflect a gradual sea ice retreat from station 77 KL to 85KL during the global warming and sea level rise. Moderate bottom-water oxygenation is suggested for the intermediate depths of 1 km whereas no changes in relative oxygen content are found at 2 km below sea level during the Younger Dryas. Concurrent decrease in bioproductivity is reconstructed from BF records from the core 85KL. However, presence of high-productivity species and elevated BF accumulation rates in the core 77KL point to higher organic matter flux to the sea floor in the southern part of the ridge at the end of Younger Dryas. For the Early Holocene, bioproductivity rise and oxygen depletion in the intermediate waters are inferred from BF data. Strong dominance of dysoxic group

  2. Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents.

    PubMed

    Mosca, Antonella; Nobili, Valerio; De Vito, Rita; Crudele, Annalisa; Scorletti, Eleonora; Villani, Alberto; Alisi, Anna; Byrne, Christopher D

    2017-05-01

    Recent research has suggested that dietary fructose intake may increase serum uric acid (UA) concentrations. Both UA concentration and fructose consumption maybe also increase in NAFLD. It is not known whether dietary fructose consumption and UA concentration are independently associated with non-alcoholic steatohepatitis (NASH). Our aim was to investigate the factors associated with NASH in children and adolescents with proven NAFLD, and to test whether UA concentrations and fructose consumption are independently associated with NASH. Obese children with NAFLD were studied (n=271). NASH was diagnosed by a NAFLD activity score ⩾5 and the fatty liver inhibition of progression (FLIP) algorithm. Fructose consumption (g/day) was assessed by food frequency questionnaire, and UA (mg/dl) was measured in serum. Binary logistic regression with adjustment for covariates and potential confounders was undertaken to test factors independently associated with NASH. NASH occurred in 37.6% of patients. Hyperuricaemia (UA ⩾5.9mg/dl) was present in 47% of patients with NASH compared with 29.7% of non-NASH patients (p=0.003). Both UA concentration (OR=2.488, 95% CI: 1.87-2.83, p=0.004) and fructose consumption (OR=1.612, 95% CI 1.25-1.86, p=0.001) were independently associated with NASH, after adjustment for multiple (and all) measured confounders. Fructose consumption was independently associated with hyperuricaemia (OR=2.021, 95% CI: 1.66-2.78, p=0.01). These data were confirmed using the FLIP algorithm. Both dietary fructose consumption and serum UA concentrations are independently associated with NASH. Fructose consumption was the only factor independently associated with serum UA concentration. Currently, it is not known whether dietary fructose consumption and uric acid (UA) concentration are linked with non-alcoholic steatohepatitis (NASH) in children and adolescents. Our aim was to test whether UA concentrations and fructose consumption are independently associated with

  3. NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

    PubMed Central

    van Rooyen, Derrick; Gan, Lay; Chitturi, Shivrakumar

    2012-01-01

    While non-alcoholic fatty liver disease (NAFLD) is highly prevalent (15% to 45%) in modern societies, only 10% to 25% of cases develop hepatic fibrosis leading to cirrhosis, end-stage liver disease or hepatocellular carcinoma. Apart from pre-existing fibrosis, the strongest predictor of fibrotic progression in NAFLD is steatohepatitis or non-alcoholic steatohepatitis (NASH). The critical features other than steatosis are hepatocellular degeneration (ballooning, Mallory hyaline) and mixed inflammatory cell infiltration. While much is understood about the relationship of steatosis to metabolic factors (over-nutrition, insulin resistance, hyperglycemia, metabolic syndrome, hypoadiponectinemia), less is known about inflammatory recruitment, despite its importance for the perpetuation of liver injury and fibrogenesis. In this review, we present evidence that liver inflammation has prognostic significance in NAFLD. We then consider the origins and components of liver inflammation in NASH. Hepatocytes injured by toxic lipid molecules (lipotoxicity) play a central role in the recruitment of innate immunity involving Toll-like receptors (TLRs), Kupffer cells (KCs), lymphocytes and neutrophils and possibly inflammasome. The key pro-inflammatory signaling pathways in NASH are nuclear factor-kappa B (NF-κB) and c-Jun N-terminal kinase (JNK). The downstream effectors include adhesion molecules, chemokines, cytokines and the activation of cell death pathways leading to apoptosis. The upstream activators of NF-κB and JNK are more contentious and may depend on the experimental model used. TLRs are strong contenders. It remains possible that inflammation in NASH originates outside the liver and in the gut microbiota that prime KC/TLR responses, inflamed adipose tissue and circulating inflammatory cells. We briefly review these mechanistic considerations and project their implications for the effective treatment of NASH. PMID:22570745

  4. Plate convergence and deformation, North Luzon Ridge, Philippines

    NASA Astrophysics Data System (ADS)

    Lewis, Stephen D.; Hayes, Dennis E.

    1989-10-01

    Marine geophysical and earthquake seismology data indicate that the North Luzon Ridge, a volcano-capped bathymetrie ridge system that extends between Luzon and Taiwan, is presently undergoing deformation in response to the relative motion between the Asian and Philippine Sea plates. Plate motion models predict convergence along the western side of the Philippine Sea plate, from Japan in the north to Indonesia in the south, and most of this plate margin is defined by active subduction zones. However, the western boundary of the Philippine Sea plate adjacent to the North Luzon Ridge shows no evidence of an active WNW-dipping subduction zone; this is in marked contrast to the presence of both the Philippine Trench/East Luzon Trough subduction zones to the south and the Ryukyu Trench subduction zone to the north. Crustal shortening, in response to ongoing plate convergence in the North Luzon Ridge region, apparently takes place through a complex pattern of strike-slip and thrust faulting, rather than by the typical subduction of oceanic lithosphere along a discreet zone. The curvilinear bathymetrie trends within the North Luzon Ridge represent the traces of active faults. The distribution of these faults, mapped by both multichannel and single-channel seismic reflection methods and earthquake seismicity patterns and focal mechanism solutions, suggest that right-lateral, oblique-slip faulting occurs along NE-trending faults, and left-lateral, oblique-slip faulting takes place on N- and NNW-trending faults. The relative plate convergence accommodated by the deformation of the North Luzon Ridge will probably be taken up in the future by the northward-propagating East Luzon Trough subduction zone.

  5. Wrinkle ridges in the floor material of Kasei Valles, Mars: Nature and origin

    NASA Technical Reports Server (NTRS)

    Watters, Thomas R.; Craddock, Robert A.

    1991-01-01

    Wrinkle ridges on Mars occur almost exclusively in smooth plains material referred to as ridged plains. One of the largest contiguous units of ridged plains occurs on Lunae Planum on the eastern flank of the Tharsis rise. The eastern, western, and northern margins of the ridged plains of Lunae Planum suffered extensive erosion in early Amazonian channel-forming events. The most dramatic example of erosion in early Amazonian plains is in Kasei Valles. The nature an origin of the wrinkle ridges in the floor material of Kasei Valles are discussed.

  6. Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment

    PubMed Central

    Dongiovanni, Paola; Anstee, Quentin M; Valenti, Luca

    2013-01-01

    Liver fat deposition related to systemic insulin resistance defines non-alcoholic fatty liver disease (NAFLD) which, when associated with oxidative hepatocellular damage, inflammation, and activation of fibrogenesis, i.e. non-alcoholic steatohepatitis (NASH), can progress towards cirrhosis and hepatocellular carcinoma. Due to the epidemic of obesity, NAFLD is now the most frequent liver disease and the leading cause of altered liver enzymes in Western countries. Epidemiological, familial, and twin studies provide evidence for an element of heritability of NAFLD. Genetic modifiers of disease severity and progression have been identified through genome-wide association studies. These include the Patatin-like phosholipase domain-containing 3 (PNPLA3) gene variant I148M as a major determinant of inter-individual and ethnicity-related differences in hepatic fat content independent of insulin resistance and serum lipid concentration. Association studies confirm that the I148M polymorphism is also a strong modifier of NASH and progressive hepatic injury. Furthermore, a few large multicentre case-control studies have demonstrated a role for genetic variants implicated in insulin signalling, oxidative stress, and fibrogenesis in the progression of NAFLD towards fibrosing NASH, and confirm that hepatocellular fat accumulation and insulin resistance are key operative mechanisms closely involved in the progression of liver damage. It is now important to explore the molecular mechanisms underlying these associations between gene variants and progressive liver disease, and to evaluate their impact on the response to available therapies. It is hoped that this knowledge will offer further insights into pathogenesis, suggest novel therapeutic targets, and could help guide physicians towards individualised therapy that improves clinical outcome. PMID:23394097

  7. On Nash-Equilibria of Approximation-Stable Games

    NASA Astrophysics Data System (ADS)

    Awasthi, Pranjal; Balcan, Maria-Florina; Blum, Avrim; Sheffet, Or; Vempala, Santosh

    One reason for wanting to compute an (approximate) Nash equilibrium of a game is to predict how players will play. However, if the game has multiple equilibria that are far apart, or ɛ-equilibria that are far in variation distance from the true Nash equilibrium strategies, then this prediction may not be possible even in principle. Motivated by this consideration, in this paper we define the notion of games that are approximation stable, meaning that all ɛ-approximate equilibria are contained inside a small ball of radius Δ around a true equilibrium, and investigate a number of their properties. Many natural small games such as matching pennies and rock-paper-scissors are indeed approximation stable. We show furthermore there exist 2-player n-by-n approximation-stable games in which the Nash equilibrium and all approximate equilibria have support Ω(log n). On the other hand, we show all (ɛ,Δ) approximation-stable games must have an ɛ-equilibrium of support O(Δ^{2-o(1)}/ɛ2{log n}), yielding an immediate n^{O(Δ^{2-o(1)}/ɛ^2log n)}-time algorithm, improving over the bound of [11] for games satisfying this condition. We in addition give a polynomial-time algorithm for the case that Δ and ɛ are sufficiently close together. We also consider an inverse property, namely that all non-approximate equilibria are far from some true equilibrium, and give an efficient algorithm for games satisfying that condition.

  8. Nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy: association of pancreatic exocrine deficiency and infection.

    PubMed

    Murata, Yasuhiro; Mizuno, Shugo; Kato, Hiroyuki; Kishiwada, Masashi; Ohsawa, Ichiro; Hamada, Takashi; Usui, Masanobu; Sakurai, Hiroyuki; Tabata, Masami; Nishimura, Keisuke; Fukutome, Kazuo; Isaji, Shuji

    2011-08-01

    Previous clinical study has demonstrated that 30-40% of patients undergoing pancreaticoduodenectomy (PD) developed hepatic steatosis. However, nonalcoholic steatohepatitis (NASH) is a little-known complication after PD. Recently we encountered two patients with PD who later developed NASH diagnosed by liver biopsy. Case 1 was a 79-year-old woman who underwent PD for intraductal papillary mucinous neoplasm (IPMN). She had postoperative severe diarrhea due to pseudomembranous enterocolitis. Severe liver dysfunction was observed on the 31st postoperative day. Abdominal computed tomography (CT) on the 32nd day showed remarkably decreased hepatic CT value of 6 HU. Immediate liver biopsy revealed NASH (Brunt criteria: grade 2, stage 2). Case 2 was a 71-year-old woman who underwent PD for IPMN. Liver biopsy on 70th postoperative day, which was performed for assessment of moderate liver dysfunction and decreased hepatic CT value of 44 HU, demonstrated simple steatosis. In the 21st postoperative month, she developed severe urinary tract infection together with marked liver dysfunction. Immediate liver biopsy revealed NASH (Brunt criteria: grade 1, stage 1). For each patient, treatment of infection and high-dose pancreatic enzyme supplements improved liver dysfunction and liver steatosis. Clinical features of our cases seem to support the current leading hypothesis of the pathogenesis of NASH, i.e., the two-hit theory.

  9. 76 FR 27173 - Carolina Coastal Railway, Inc.-Acquisition and Operation Exemption-Rocky Mount & Western Railroad...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... Railway, Inc.--Acquisition and Operation Exemption--Rocky Mount & Western Railroad Co., Inc. d/b/a Nash County Railroad Carolina Coastal Railway, Inc. (CLNA), a Class III rail carrier, has filed a verified notice of exemption under 49 CFR 1150.41 to acquire from Rocky Mount & Western Railroad Co., Inc. d/b/a...

  10. Seismic and Tectonic Monitoring of the Endeavour Ridge Segment—Recent and Future Expansion of Ocean Networks Canada's NEPTUNE Observatory on the Juan de Fuca Ridge

    NASA Astrophysics Data System (ADS)

    Heesemann, M.; Davis, E. E.; Scherwath, M.; Kao, H.; Coogan, L. A.; Rogers, G. C.; Wilcock, W. S. D.

    2016-12-01

    Ocean Networks Canada's (ONC) NEPTUNE observatory provides real-time access to sensors on the Endeavour Ridge Segment (Endeavour)—a focus site on the Juan de Fuca Ridge System that is complementary to one on Axial Volcano that is connected through the Ocean Observatories Initiative's (OOI) Cabled Array. While first instruments (including cameras, a short-period seismometer, and vent monitoring instruments) installed at the Main Endeavour vent field have been sending data since summer 2010, unreliable extension cables precluded continuous time-series from other nearby locations. With the successful installation of four extension cables, the summer of 2016 represents an important milestone in the instrumentation of the Endeavour Ridge Segment. We will present an overview of the data that are available in near real-time from Endeavour and new instrumentation that is scheduled for installation in 2017, and highlight first results derived from the new seismo-tectonic network now in operation. This network consists of three short-period seismometers (Mothra Field, Main Endeavour Field, Regional Circulation North), one broadband seismometer (western Ridge Flank), and four bottom pressure recorders (Mothra Field, Regional Circulation South, Main Endeavour Field, western Ridge Flank). The pressure recorders will provide both seismic and oceanographic data, and allow to measure differential vertical motion among the sites. We will also highlight a new technique to determine long period seafloor deformation from broadband seismometer mass-position measurements, using data from the Ridge Flank instrument as an example.

  11. Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?

    PubMed Central

    Lytle, Kelli A.; Jump, Donald B.

    2016-01-01

    Background Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH, validating treatment protocols (i.e., low fat diets and weight loss) is imperative. Methods We evaluated the efficacy of two diets, a non-purified chow (NP) and purified (low-fat low-cholesterol, LFLC) diet to reverse western diet (WD)-induced NASH and fibrosis in Ldlr-/- mice. Results Mice fed WD for 22–24 weeks developed robust hepatosteatosis with mild fibrosis, while mice maintained on the WD an additional 7–8 weeks developed NASH with moderate fibrosis. Returning WD-fed mice to the NP or LFLC diets significantly reduced body weight and plasma markers of metabolic syndrome (dyslipidemia, hyperglycemia) and hepatic gene expression markers of inflammation (Mcp1), oxidative stress (Nox2), fibrosis (Col1A, LoxL2, Timp1) and collagen crosslinking (hydroxyproline). Time course analyses established that plasma triglycerides and hepatic Col1A1 mRNA were rapidly reduced following the switch from the WD to the LFLC diet. However, hepatic triglyceride content and fibrosis did not return to normal levels 8 weeks after the change to the LFLC diet. Time course studies further revealed a strong association (r2 ≥ 0.52) between plasma markers of inflammation (TLR2 activators) and hepatic fibrosis markers (Col1A, Timp1, LoxL2). Inflammation and fibrosis markers were inversely associated (r2 ≥ 0.32) with diet-induced changes in hepatic ω3 and ω6 polyunsaturated fatty acids (PUFA) content. Conclusion These studies establish a temporal link between plasma markers of inflammation and hepatic PUFA and fibrosis. Low-fat low-cholesterol diets promote reversal of many, but not all, features associated with WD

  12. Horse Ridge Research Natural Area: guidebook supplement 37.

    Treesearch

    Reid Schuller; Ron. Halvorson

    2008-01-01

    This guidebook describes Horse Ridge Research Natural Area, a 243-ha (600-ac) tract established to represent an example of the western juniper/big sagebrush/threadleaf sedge (Juniperus occidentalis/Artemisia tridentata/Carex filifolia) plant association.

  13. Water extract of Vitis coignetiae Pulliat leaves attenuates oxidative stress and inflammation in progressive NASH rats.

    PubMed

    Pak, Wing; Takayama, Fusako; Hasegawa, Azusa; Mankura, Mitsumasa; Egashira, Toru; Ueki, Keiji; Nakamoto, Kazuo; Kawasaki, Hiromu; Mori, Akitane

    2012-01-01

    This study aimed to investigate the therapeutic effects of the water extract of leaves of Vitis coignetiae Pulliat (VCPL) on nonalcoholic steatohepatitis (NASH) with advanced fibrosis, as our previous study exhibited its preventive effect on NASH. The NASH animal model [PCT/JP2007/52477] was prepared by loading recurrent and intermittent hypoxemia stress to a rat with fatty liver, which resembled the condition occurring in patients with obstructive sleep apnea (OSA) and fatty liver, who have a high incidence of NASH. Intermittent hypoxemia stress is regarded as a condition similar to warm ischemia followed by re-oxygenation, which induces oxidative stress (OS). The daily 100 or 300 mg/kg VCPL administrations were performed for 3 weeks perorally beginning at the time of detection of advanced liver fibrosis. The therapeutic efficacy of VCPL on NASH was demonstrated by the reduction of the leakage of hepato-biliary enzymes and the amelioration of liver fibrosis. The OS elevation in NASH rats was measured based on the derivation of reactive oxygen species from liver mitochondrial energy metabolism and on the decrease in plasma SOD-like activity. The aggravation of inflammatory responses was demonstrated by the neutrophil infiltration (elevated myeloperoxidase activity) and the progression of fibrosis in the livers of NASH rats. In addition, the NASH rats without VCPL treatment also exhibited activation of nuclear factor-κB, a key factor in the link between oxidative stress and inflammation. All of these changes were reduced dose-dependently by the VCPL administration. These findings indicate that VCPL may improve hepatic fibrosis or at least suppress the progression of NASH, by breaking the crosstalk between OS and inflammation.

  14. Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

    PubMed

    Caballero, Francisco; Fernández, Anna; De Lacy, Antonio M; Fernández-Checa, Jose C; Caballería, Juan; García-Ruiz, Carmen

    2009-04-01

    Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains unknown. Due to the emerging role of free cholesterol (FC) in NAFLD, our aim was to examine the correlation between FC accumulation in patients with NAFLD and the expression of enzymes that regulate cholesterol homeostasis. Filipin staining, indicative of FC accumulation, and real-time PCR analyses were performed in 31 NAFLD patients and in seven controls. All NASH patients (n=14) and 4 out of 17 patients with steatosis exhibited filipin staining compared to controls (0 out of 7 subjects with normal liver histology and BMI). Sterol regulatory element-binding protein-2 (SREBP-2) mRNA levels were 7- and 3-fold higher in NASH and steatosis patients, respectively, compared to controls. Since hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the key enzyme in cholesterol synthesis and transcriptionally controlled by SREBP-2 we measured its mRNA levels, being 3- to 4-fold higher in NAFLD compared to controls, without any difference between NASH and steatosis patients. Fatty acid synthase (FAS) and SREBP-1c expression were not significantly induced in NAFLD, while ATP-binding cassette sub-family G member 1 (ABCG1), a transporter involved in cholesterol egress, and acyl-CoA-cholesterol acyltransferase mRNA levels were modestly increased (1.5- to 2.5-fold, p<0.05), regardless of fibrosis. Interestingly, mRNA levels of steroidogenic acute regulatory protein (StAR), a mitochondrial-cholesterol transporting polypeptide, increased 7- and 15-fold in steatosis and NASH patients, respectively, compared to controls. FC increases in NASH and correlates with SREBP-2 induction. Moreover, StAR overexpression in NASH suggests that mitochondrial FC may be a player in disease progression and a novel target for intervention.

  15. Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.

    PubMed

    Lim, Andrea; Zhou, Jin; Sinha, Rohit A; Singh, Brijesh K; Ghosh, Sujoy; Lim, Kiat-Hon; Chow, Pierce Kah-Hoe; Woon, Esther C Y; Yen, Paul M

    2016-10-21

    Non-alcoholic steatohepatitis (NASH) is one of the most common causes of liver failure worldwide. It is characterized by excess fat accumulation, inflammation, and increased lipotoxicity in hepatocytes. Currently, there are limited treatment options for NASH due to lack of understanding of its molecular etiology. In the present study, we demonstrate that the expression of fat mass and obesity associated gene (FTO) is significantly increased in the livers of NASH patients and in a rodent model of NASH. Furthermore, using human hepatic cells, we show that genetic silencing of FTO protects against palmitate-induced oxidative stress, mitochondrial dysfunction, ER stress, and apoptosis in vitro. Taken together, our results show that FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and strongly suggest that up-regulation of FTO may contribute to the increased liver damage in NASH. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Overexpression of the Vitronectin V10 Subunit in Patients with Nonalcoholic Steatohepatitis: Implications for Noninvasive Diagnosis of NASH.

    PubMed

    Del Ben, Maria; Overi, Diletta; Polimeni, Licia; Carpino, Guido; Labbadia, Giancarlo; Baratta, Francesco; Pastori, Daniele; Noce, Valeria; Gaudio, Eugenio; Angelico, Francesco; Mancone, Carmine

    2018-02-18

    Nonalcoholic steatohepatitis (NASH) is the critical stage of nonalcoholic fatty liver disease (NAFLD). The persistence of necroinflammatory lesions and fibrogenesis in NASH is the leading cause of liver cirrhosis and, ultimately, hepatocellular carcinoma. To date, the histological examination of liver biopsies, albeit invasive, remains the means to distinguish NASH from simple steatosis (NAFL). Therefore, a noninvasive diagnosis by serum biomarkers is eagerly needed. Here, by a proteomic approach, we analysed the soluble low-molecular-weight protein fragments flushed out from the liver tissue of NAFL and NASH patients. On the basis of the assumption that steatohepatitis leads to the remodelling of the liver extracellular matrix (ECM), NASH-specific fragments were in silico analysed for their involvement in the ECM molecular composition. The 10 kDa C-terminal fragment of the ECM protein vitronectin (VTN) was then selected as a promising circulating biomarker in discriminating NASH. The analysis of sera of patients provided these major findings: the circulating VTN fragment (i) is overexpressed in NASH patients and positively correlates with the NASH activity score (NAS); (ii) originates from the disulfide bond reduction between the V10 and the V65 subunits. In conclusion, V10 determination in the serum could represent a reliable tool for the noninvasive discrimination of NASH from simple steatosis.

  17. Nash equilibrium and multi criterion aerodynamic optimization

    NASA Astrophysics Data System (ADS)

    Tang, Zhili; Zhang, Lianhe

    2016-06-01

    Game theory and its particular Nash Equilibrium (NE) are gaining importance in solving Multi Criterion Optimization (MCO) in engineering problems over the past decade. The solution of a MCO problem can be viewed as a NE under the concept of competitive games. This paper surveyed/proposed four efficient algorithms for calculating a NE of a MCO problem. Existence and equivalence of the solution are analyzed and proved in the paper based on fixed point theorem. Specific virtual symmetric Nash game is also presented to set up an optimization strategy for single objective optimization problems. Two numerical examples are presented to verify proposed algorithms. One is mathematical functions' optimization to illustrate detailed numerical procedures of algorithms, the other is aerodynamic drag reduction of civil transport wing fuselage configuration by using virtual game. The successful application validates efficiency of algorithms in solving complex aerodynamic optimization problem.

  18. Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation

    PubMed Central

    Peverill, William; Powell, Lawrie W.; Skoien, Richard

    2014-01-01

    Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the pathogenesis of NASH is still evolving but current evidence suggests multiple metabolic factors critically disrupt homeostasis and induce an inflammatory cascade and ensuing fibrosis. The mechanisms underlying these changes and the complex inter-cellular interactions that mediate fibrogenesis are yet to be fully elucidated. Lipotoxicity, in the setting of excess free fatty acids, obesity, and insulin resistance, appears to be the central driver of cellular injury via oxidative stress. Hepatocyte apoptosis and/or senescence contribute to activation of the inflammasome via a variety of intra- and inter-cellular signalling mechanisms leading to fibrosis. Current evidence suggests that periportal components, including the ductular reaction and expansion of the hepatic progenitor cell compartment, may be involved and that the Th17 response may mediate disease progression. This review aims to provide an overview of the pathogenesis of NASH and summarises the evidence pertaining to key mechanisms implicated in the transition from steatosis and inflammation to fibrosis. Currently there are limited treatments for NASH although an increasing understanding of its pathogenesis will likely improve the development and use of interventions in the future. PMID:24830559

  19. Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model

    PubMed Central

    Stefano, J.T.; Pereira, I.V.A.; Torres, M.M.; Bida, P.M.; Coelho, A.M.M.; Xerfan, M.P.; Cogliati, B.; Barbeiro, D.F.; Mazo, D.F.C.; Kubrusly, M.S.; D'Albuquerque, L.A.C.; Souza, H.P.; Carrilho, F.J.; Oliveira, C.P.

    2015-01-01

    Liver fibrosis occurring as an outcome of non-alcoholic steatohepatitis (NASH) can precede the development of cirrhosis. We investigated the effects of sorafenib in preventing liver fibrosis in a rodent model of NASH. Adult Sprague-Dawley rats were fed a choline-deficient high-fat diet and exposed to diethylnitrosamine for 6 weeks. The NASH group (n=10) received vehicle and the sorafenib group (n=10) received 2.5 mg·kg-1·day-1 by gavage. A control group (n=4) received only standard diet and vehicle. Following treatment, animals were sacrificed and liver tissue was collected for histologic examination, mRNA isolation, and analysis of mitochondrial function. Genes related to fibrosis (MMP9, TIMP1, TIMP2), oxidative stress (HSP60, HSP90, GST), and mitochondrial biogenesis (PGC1α) were evaluated by real-time quantitative polymerase chain reaction (RT-qPCR). Liver mitochondrial oxidation activity was measured by a polarographic method, and cytokines by enzyme-linked immunosorbent assay (ELISA). Sorafenib treatment restored mitochondrial function and reduced collagen deposition by nearly 63% compared to the NASH group. Sorafenib upregulated PGC1α and MMP9 and reduced TIMP1 and TIMP2 mRNA and IL-6 and IL-10 protein expression. There were no differences in HSP60, HSP90 and GST expression. Sorafenib modulated PGC1α expression, improved mitochondrial respiration and prevented collagen deposition. It may, therefore, be useful in the treatment of liver fibrosis in NASH. PMID:25714891

  20. Gary Nash: Repairing a Necessary Connection

    ERIC Educational Resources Information Center

    Bender, Thomas

    2009-01-01

    In this essay, the author comments on the life and the contributions of author Gary Nash. Everyone is thanking him for his remarkable engagement with the schools, as a writer of outstanding textbooks and materials for teachers developed through his work as director of the Center for Teaching History in the Schools, and, of course, the National…

  1. Reevaluating the age of the Walden Creek Group and the kinematic evolution of the western Blue Ridge, southern Appalachians

    USGS Publications Warehouse

    Thigpen, J. Ryan; Hatcher, Robert D.; Kah, Linda C.; Repetski, John E.

    2016-01-01

    An integrated synthesis of existing datasets (detailed geologic mapping, geochronologic, paleontologic, geophysical) with new paleontologic and geochemical investigations of rocks previously interpreted as part of the Neoproterozoic Walden Creek Group in southeastern Tennessee suggest a necessary reevaluation of the kinematics and structural architecture of the Blue Ridge Foothills. The western Blue Ridge of Tennessee, North Carolina, and Georgia is composed of numerous northwest-directed early and late Paleozoic thrust sheets, which record pronounced variation in stratigraphic/structural architecture and timing of metamorphism. The detailed spatial, temporal, and kinematic relationships of these rocks have remained controversial. Two fault blocks that are structurally isolated between the Great Smoky and Miller Cove-Greenbrier thrust sheets, here designated the Maggies Mill and Citico thrust sheets, contain Late Ordovician-Devonian conodonts and stable isotope chemostratigraphic signatures consistent with a mid-Paleozoic age. Geochemical and paleontological analyses of Walden Creek Group rocks northwest and southeast of these two thrust sheets, however, are more consistent with a Late Neoproterozoic (550–545 Ma) depositional age. Consequently, the structural juxtaposition of mid-Paleozoic rocks within a demonstrably Neoproterozoic-Cambrian succession between the Great Smoky and Miller Cove-Greenbrier thrust sheets suggests that a simple foreland-propagating thrust sequence model is not applicable in the Blue Ridge Foothills. We propose that these younger rocks were deposited landward of the Ocoee Supergroup, and were subsequently plucked from the Great Smoky fault footwall as a horse, and breached through the Great Smoky thrust sheet during Alleghanian emplacement of that structure.

  2. Nitrogen Stimulates the Growth of Subsurface Basalt-associated Microorganisms at the Western Flank of the Mid-Atlantic Ridge

    PubMed Central

    Zhang, Xinxu; Fang, Jing; Bach, Wolfgang; Edwards, Katrina J.; Orcutt, Beth N.; Wang, Fengping

    2016-01-01

    Oceanic crust constitutes the largest aquifer system on Earth, and microbial activity in this environment has been inferred from various geochemical analyses. However, empirical documentation of microbial activity from subsurface basalts is still lacking, particularly in the cool (<25°C) regions of the crust, where are assumed to harbor active iron-oxidizing microbial communities. To test this hypothesis, we report the enrichment and isolation of crust-associated microorganisms from North Pond, a site of relatively young and cold basaltic basement on the western flank of the Mid-Atlantic Ridge that was sampled during Expedition 336 of the Integrated Ocean Drilling Program. Enrichment experiments with different carbon (bicarbonate, acetate, methane) and nitrogen (nitrate and ammonium) sources revealed significant cell growth (one magnitude higher cell abundance), higher intracellular DNA content, and increased Fe3+/ΣFe ratios only when nitrogen substrates were added. Furthermore, a Marinobacter strain with neutrophilic iron-oxidizing capabilities was isolated from the basalt. This work reveals that basalt-associated microorganisms at North Pond had the potential for activity and that microbial growth could be stimulated by in vitro nitrogen addition. Furthermore, iron oxidation is supported as an important process for microbial communities in subsurface basalts from young and cool ridge flank basement. PMID:27199959

  3. Effects of Cocos Ridge Collision on the Western Caribbean: Is there a Panama Block?

    NASA Astrophysics Data System (ADS)

    Kobayashi, D.; La Femina, P. C.; Geirsson, H.; Chichaco, E.; Abrego M, A. A.; Fisher, D. M.; Camacho, E. I.

    2011-12-01

    It has been recognized that the subduction and collision of the Cocos Ridge, a 2 km high aseismic ridge standing on >20 km thick oceanic crust of the Cocos plate, drives upper plate deformation in southern Central America. Recent studies of Global Positioning System (GPS) derived horizontal velocities relative to the Caribbean Plate showed a radial pattern centered on the Cocos Ridge axis where Cocos-Caribbean convergence is orthogonal, and margin-parallel velocities to the northwest. Models of the full three-dimensional GPS velocity field and earthquake slip vectors demonstrate low mechanical coupling along the Middle America subduction zone in Nicaragua and El Salvador, and a broad zone of high coupling beneath the Osa Peninsula, where the Cocos Ridge intersects the margin. These results suggest that Cocos Ridge collision may be the main driver for trench-parallel motion of the fore arc to the northwest and for uplift and shortening of the outer fore arc in southern Central America, whereby thickened and hence buoyant Cocos Ridge crust acts as an indenter causing the tectonic escape of the fore arc. These studies, however, were not able to constrain well the pattern of surface deformation east-southeast of the ridge axis due to a lack of GPS stations, and Cocos Ridge collision may be responsible for the kinematics and deformation of the proposed Panama block. Recent reinforcement of the GPS network in southeastern Costa Rica and Panama has increased the spatial and temporal resolution of the network and made it possible to further investigate surface deformation of southern Central America and the Panama block. We present a new regional surface velocity field for Central America from geodetic GPS data collected at 11 recently-installed and 178 existing episodic, semi-continuous, and continuous GPS sites in Nicaragua, Costa Rica, and Panama. We investigate the effects of Cocos Ridge collision on the Panama block through kinematic block modeling. Published

  4. Interpretation of bathymetric and magnetic data from the easternmost segment of Australian-Antarctic Ridge, 156°-161°E

    NASA Astrophysics Data System (ADS)

    Choi, H.; Kim, S.; Park, S.

    2013-12-01

    From 2011 to 2013, Korea Polar Research Institute (KOPRI) conducted a series of geophysical and geochemical expeditions on the longest and easternmost segment of Australian-Antarctic Ridge, located at 61°-63°S, and 156°-161°E. This ridge segment plays an important role in constraining the tectonics of the Antarctic plate. Using IBRV ARAON, the detailed bathymetric data and eleven total magnetic profiles were collected. The studied ridge has spread NNW-SSE direction and tends to be shallower to the west and deeper to the east. The western side of the ridge (156°-157.50°E) shows a broad axial high and a plenty of seamounts as an indicative of massive volcanism. Near the center of the ridge (158°-159°E), a seamount chain is formed stretching toward the south from the ridge. Also, the symmetric seafloor fabric is clearly observed at the eastern portion (158.50°-160°E) of the seamount chain. From the topographic change along the ridge axis, the western part of the ridge appears to have a sufficient magma supply. On the contrary, the eastern side of the ridge (160°-161°E) is characterized by axial valley and relatively deeper depth. Nevertheless, the observed total magnetic field anomalies exhibit symmetric patterns across the ridge axis. Although there have not been enough magnetic survey lines, the spreading rates of the ridge are estimated as the half-spreading rate of 37.7 mm/y and 35.3 mm/y for the western portion of the ridge and 42.3 mm/y for the eastern portion. The studied ridge can be categorized as an intermediate spreading ridge, confirming previous studies based on the spreading rate of global ridge system. Here we will present the preliminary results on bathymetric changes along the ridge axis and its relationship with melt supply distribution, and detailed magnetic properties of the ridge constrained by the observed total field anomalies.

  5. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.

    PubMed

    Mridha, Auvro R; Wree, Alexander; Robertson, Avril A B; Yeh, Matthew M; Johnson, Casey D; Van Rooyen, Derrick M; Haczeyni, Fahrettin; Teoh, Narci C-H; Savard, Christopher; Ioannou, George N; Masters, Seth L; Schroder, Kate; Cooper, Matthew A; Feldstein, Ariel E; Farrell, Geoffrey C

    2017-05-01

    NOD-like receptor protein 3 (NLRP3) inflammasome activation occurs in Non-alcoholic fatty liver disease (NAFLD). We used the first small molecule NLRP3 inhibitor, MCC950, to test whether inflammasome blockade alters inflammatory recruitment and liver fibrosis in two murine models of steatohepatitis. We fed foz/foz and wild-type mice an atherogenic diet for 16weeks, gavaged MCC950 or vehicle until 24weeks, then determined NAFLD phenotype. In mice fed an methionine/choline deficient (MCD) diet, we gavaged MCC950 or vehicle for 6weeks and determined the effects on liver fibrosis. In vehicle-treated foz/foz mice, hepatic expression of NLRP3, pro-IL-1β, active caspase-1 and IL-1β increased at 24weeks, in association with cholesterol crystal formation and NASH pathology; plasma IL-1β, IL-6, MCP-1, ALT/AST all increased. MCC950 treatment normalized hepatic caspase 1 and IL-1β expression, plasma IL-1β, MCP-1 and IL-6, lowered ALT/AST, and reduced the severity of liver inflammation including designation as NASH pathology, and liver fibrosis. In vitro, cholesterol crystals activated Kupffer cells and macrophages to release IL-1β; MCC950 abolished this, and the associated neutrophil migration. MCD diet-fed mice developed fibrotic steatohepatitis; MCC950 suppressed the increase in hepatic caspase 1 and IL-1β, lowered numbers of macrophages and neutrophils in the liver, and improved liver fibrosis. MCC950, an NLRP3 selective inhibitor, improved NAFLD pathology and fibrosis in obese diabetic mice. This is potentially attributable to the blockade of cholesterol crystal-mediated NLRP3 activation in myeloid cells. MCC950 reduced liver fibrosis in MCD-fed mice. Targeting NLRP3 is a logical direction in pharmacotherapy of NASH. Fatty liver disease caused by being overweight with diabetes and a high risk of heart attack, termed non-alcoholic steatohepatitis (NASH), is the most common serious liver disease with no current treatment. There could be several causes of inflammation

  6. New data of the Gakkel Ridge seismicity

    NASA Astrophysics Data System (ADS)

    Antonovskaya, Galina; Basakina, Irina; Kremenetskaya, Elena

    2016-04-01

    250 earthquakes were recorded in the Gakkel Ridge during the period 2012-2014 by Arkhangelsk seismic network. The magnitude Ml of these earthquakes is 1.5 - 5.7, 70% of them have Ml up to 3.0. Seismic events are arranged along to a narrow center line of the Mid-Arctic Ridge, most of the earthquakes are confined to the southern board of the Ridge. Presumably it's connected with the reflection of spreading processes. The high seismic activity zones, which we associate with the volcano-tectonic processes, have been identified. Have been recorded 13 events per day in the Western Volcanic Zone. The largest number of events (75%) is confined to the Sparsely Magmatic Zone. About 30% of all recorded earthquakes with magnitudes above 2.9 have a T-phase. We divided the Gakkel Ridge's earthquakes into two groups by using spectral-time analysis. The first group: maximum energy of the earthquake is observed from 1.5 to 10 Hz, values of magnitudes Ml 2.50-5.29. Earthquakes are distributed along the Gakkel Ridge. The second group: maximum energy of the earthquake is observed from 1.5 to 20 Hz, clearly expressed a high-frequency component, values of magnitudes Ml 2.3-3.4. Earthquakes 2 groups focused only in the Sparsely Magmatic Zone. The new seismic data shows an unique information about geodynamic processes of the Gakkel Ridge.

  7. Grace Nash: Nine Decades of Graceful Teaching.

    ERIC Educational Resources Information Center

    Cole, Judith

    2000-01-01

    Provides information on the life of Grace Nash, an influential educator and pioneer of Orff Schulwerk in the United States, focusing on issues such as her young life, experience as a prisoner-of-war, development of her interest in the Orff, Kodaly, and Laban methods, and her own work. Offers selected resources. (CMK)

  8. Geophysical Characteristics of the Australian-Antarctic Ridge

    NASA Astrophysics Data System (ADS)

    Kim, S. S.; Lin, J.; Park, S. H.; Choi, H.; Lee, S. M.

    2014-12-01

    Between 2011 and 2013, the Korea Polar Research Institute (KOPRI) conducted three consecutive geologic surveys at the little explored eastern ends of the Australian-Antarctic Ridge (AAR) to characterize the tectonics, geochemistry, and hydrothermal activity of this intermediate spreading system. Using the Korean icebreaker R/V Araon, the multi-disciplinary research team collected bathymetry, gravity, magnetics, and rock and water column samples. In addition, Miniature Autonomous Plume Recorders (MAPRs) were deployed at wax-core rock sampling sites to detect the presence of active hydrothermal vents. Here we present a detailed analysis of a 300-km-long supersegment of the AAR to quantify the spatial variations in ridge morphology and robust axial and off-axis volcanisms. The ridge axis morphology alternates between rift valleys and axial highs within relatively short ridge segments. To obtain a geological proxy for regional variations in magma supply, we calculated residual mantle Bouguer gravity anomalies (RMBA), gravity-derived crustal thickness, and residual topography for seven sub-segments. The results of the analyses revealed that the southern flank of the AAR is associated with shallower seafloor, more negative RMBA, thicker crust, and/or less dense mantle than the conjugate northern flank. Furthermore, this north-south asymmetry becomes more prominent toward the KR1 supersegment of the AAR. The axial topography of the KR1 supersegment exhibits a sharp transition from axial highs at the western end to rift valleys at the eastern end, with regions of axial highs being associated with more magma supply as indicated by more negative RMBA. We also compare and contrast the characteristics of the AAR supersegment with that of other ridges of intermediate spreading rates, including the Juan de Fuca Ridge, Galápagos Spreading Center, and Southeast Indian Ridge west of the Australian-Antarctic Discordance, to investigate the influence of ridge-hotspot interaction on

  9. Ridge suction drives plume-ridge interactions

    NASA Astrophysics Data System (ADS)

    Niu, Y.; Hékinian, R.

    2003-04-01

    Deep-sourced mantle plumes, if existing, are genetically independent of plate tectonics. When the ascending plumes approach lithospheric plates, interactions between the two occur. Such interactions are most prominent near ocean ridges where the lithosphere is thin and the effect of plumes is best revealed. While ocean ridges are mostly passive features in terms of plate tectonics, they play an active role in the context of plume-ridge interactions. This active role is a ridge suction force that drives asthenospheric mantle flow towards ridges because of material needs to form the ocean crust at ridges and lithospheric mantle in the vicinity of ridges. This ridge suction force increases with increasing plate separation rate because of increased material demand per unit time. As the seismic low-velocity zone atop the asthenosphere has the lowest viscosity that increases rapidly with depth, the ridge-ward asthenospheric flow is largely horizontal beneath the lithosphere. Recognizing that plume materials have two components with easily-melted dikes/veins enriched in volatiles and incompatible elements dispersed in the more refractory and depleted peridotitic matrix, geochemistry of some seafloor volcanics well illustrates that plume-ridge interactions are consequences of ridge-suction-driven flow of plume materials, which melt by decompression because of lithospheric thinning towards ridges. There are excellent examples: 1. The decreasing La/Sm and increasing MgO and CaO/Al_2O_3 in Easter Seamount lavas from Salas-y-Gomez Islands to the Easter Microplate East rift zone result from progressive decompression melting of ridge-ward flowing plume materials. 2. The similar geochemical observations in lavas along the Foundation hotline towards the Pacific-Antarctic Ridge result from the same process. 3. The increasing ridge suction force with increasing spreading rate explains why the Iceland plume has asymmetric effects on its neighboring ridges: both topographic and

  10. Memories of Gary Nash over Five Decades

    ERIC Educational Resources Information Center

    Mellor, Ronald

    2009-01-01

    It is as a longtime client, softball teammate, colleague, traveling companion, and friend that the author writes this article to honor Gary Nash. He has known him in varied guises in five different decades, and on five continents, with Africa coming in 2009. In this article, the author recalls some of his memories of Gary over five decades.

  11. Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome.

    PubMed

    Van Rooyen, Derrick M; Gan, Lay T; Yeh, Matthew M; Haigh, W Geoffrey; Larter, Claire Z; Ioannou, George; Teoh, Narci C; Farrell, Geoffrey C

    2013-07-01

    We have recently showed that hyperinsulinemia promotes hepatic free cholesterol (FC) accumulation in obese, insulin-resistant Alms1 mutant (foz/foz) mice with NASH. Here we tested whether cholesterol-lowering drugs reduce stress-activated c-Jun N-terminal kinase (JNK) activation, hepatocyte injury/apoptosis, inflammation, and fibrosis in this metabolic syndrome NASH model. Female foz/foz and WT mice were fed HF (0.2% cholesterol) 16 weeks, before adding ezetimibe (5 mg/kg), atorvastatin (20 mg/kg), or both to diet, another 8 weeks. Hepatic lipidomic analysis, ALT, liver histology, Sirius Red morphometry, hepatic mRNA and protein expression and immunohistochemistry (IHC) for apoptosis (M30), macrophages (F4/80), and polymorphs (myeloperoxidase) were determined. In mice with NASH, ezetimibe/atorvastatin combination normalized hepatic FC but did not alter saturated free fatty acids (FFA) and had minimal effects on other lipids; ezetimibe and atorvastatin had similar but less profound effects. Pharmacological lowering of FC abolished JNK activation, improved serum ALT, apoptosis, liver inflammation/NAFLD activity score, designation as "NASH", macrophage chemotactic protein-1 expression, reduced macrophage and polymorph populations, and liver fibrosis. Cholesterol lowering with ezetimibe/atorvastatin combination reverses hepatic FC but not saturated FFA accumulation. This dampens JNK activation, ALT release, hepatocyte apoptosis, and inflammatory recruitment, with reversal of steatohepatitis pathology and liver fibrosis. Ezetimibe/statin combination is a potent, mechanism-based treatment that could reverse NASH and liver fibrosis. Copyright © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  12. Western Arabia Terra

    NASA Image and Video Library

    2002-12-19

    This image from NASA Mars Odyssey covers a region in western Arabia Terra, which contains two interesting craters. The eastern floor of the largest crater seen in most of this image is bumpy and ridged in places and relatively smooth in regions.

  13. Beyond Reasonable Doubt: Who Is the Culprit in Lipotoxicity in NAFLD/NASH?

    PubMed Central

    Arteel, Gavin E.

    2016-01-01

    BACKGROUND & AIMS Type 2 diabetes and nonalcoholic steatohepatitis (NASH) are associated with insulin resistance and disordered cholesterol homeostasis. We investigated the basis for hepatic cholesterol accumulation with insulin resistance and its relevance to the pathogenesis of NASH. METHODS Alms1 mutant (foz/foz) and wild-type NOD.B10 mice were fed high-fat diets that contained varying percentages of cholesterol; hepatic lipid pools and pathways of cholesterol turnover were determined. Hepatocytes were exposed to insulin concentrations that circulate in diabetic foz/foz mice. RESULTS Hepatic cholesterol accumulation was attributed to up-regulation of low-density lipoprotein receptor via activation of sterol regulatory element binding protein 2 (SREBP-2), reduced biotransformation to bile acids, and suppression of canalicular pathways for cholesterol and bile acid excretion in bile. Exposing primary hepatocytes to concentrations of insulin that circulate in diabetic Alms1 mice replicated the increases in SREBP-2 and low-density lipoprotein receptor and suppression of bile salt export pump. Removing cholesterol from diet prevented hepatic accumulation of free cholesterol and NASH; increasing dietary cholesterol levels exacerbated hepatic accumulation of free cholesterol, hepatocyte injury or apoptosis, macrophage recruitment, and liver fibrosis. CONCLUSIONS In obese, diabetic mice, hyperinsulinemia alters nuclear transcriptional regulators of cholesterol homeostasis, leading to hepatic accumulation of free cholesterol; the resulting cytotoxicity mediates transition of steatosis to NASH. PMID:22422583

  14. Single non-invasive model to diagnose non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

    PubMed

    Otgonsuren, Munkhzul; Estep, Michael J; Hossain, Nayeem; Younossi, Elena; Frost, Spencer; Henry, Linda; Hunt, Sharon; Fang, Yun; Goodman, Zachary; Younossi, Zobair M

    2014-12-01

    Non-alcoholic steatohepatitis (NASH) is the progressive form of non-alcoholic fatty liver disease (NAFLD). A liver biopsy is considered the "gold standard" for diagnosing/staging NASH. Identification of NAFLD/NASH using non-invasive tools is important for intervention. The study aims were to: develop/validate the predictive performance of a non-invasive model (index of NASH [ION]); assess the performance of a recognized non-invasive model (fatty liver index [FLI]) compared with ION for NAFLD diagnosis; determine which non-invasive model (FLI, ION, or NAFLD fibrosis score [NFS]) performed best in predicting age-adjusted mortality. From the National Health and Nutrition Examination Survey III database, anthropometric, clinical, ultrasound, laboratory, and mortality data were obtained (n = 4458; n = 861 [19.3%] NAFLD by ultrasound) and used to develop the ION model, and then to compare the ION and FLI models for NAFLD diagnosis. For validation and diagnosis of NASH, liver biopsy data were used (n = 152). Age-adjusted Cox proportional hazard modeling estimated the association among the three non-invasive tests (FLI, ION, and NFS) and mortality. FLI's threshold score > 60 and ION's threshold score > 22 had similar specificity (FLI = 80% vs ION = 82%) for NAFLD diagnosis; FLI < 30 (80% sensitivity) and ION < 11 (81% sensitivity) excluded NAFLD. An ION score > 50 predicted histological NASH (92% specificity); the FLI model did not predict NASH or mortality. The ION model was best in predicting cardiovascular/diabetes-related mortality; NFS predicted overall or diabetes-related mortality. The ION model was superior in predicting NASH and mortality compared with the FLI model. Studies are needed to validate ION. © 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  15. Congestion schemes and Nash equilibrium in complex networks

    NASA Astrophysics Data System (ADS)

    Almendral, Juan A.; López, Luis; Cholvi, Vicent; Sanjuán, Miguel A. F.

    2005-09-01

    Whenever a common resource is scarce, a set of rules are needed to share it in a fairly way. However, most control schemes assume that users will behave in a cooperative way, without taking care of guaranteeing that they will not act in a selfish manner. Then, a fundamental issue is to evaluate the impact of cheating. From the point of view of game theory, a Nash equilibrium implies that nobody can take advantage by unilaterally deviating from this stable state, even in the presence of selfish users. In this paper we prove that any efficient Nash equilibrium strongly depends on the number of users, if the control scheme policy does not record their previous behavior. Since this is a common pattern in real situations, this implies that the system would be always out of equilibrium. Consequently, this result proves that, in practice, oblivious control schemes must be improved to cope with selfish users.

  16. Distributed Nash Equilibrium Seeking for Generalized Convex Games with Shared Constraints

    NASA Astrophysics Data System (ADS)

    Sun, Chao; Hu, Guoqiang

    2018-05-01

    In this paper, we deal with the problem of finding a Nash equilibrium for a generalized convex game. Each player is associated with a convex cost function and multiple shared constraints. Supposing that each player can exchange information with its neighbors via a connected undirected graph, the objective of this paper is to design a Nash equilibrium seeking law such that each agent minimizes its objective function in a distributed way. Consensus and singular perturbation theories are used to prove the stability of the system. A numerical example is given to show the effectiveness of the proposed algorithms.

  17. Long term highly saturated fat diet does not induce NASH in Wistar rats

    PubMed Central

    Romestaing, Caroline; Piquet, Marie-Astrid; Bedu, Elodie; Rouleau, Vincent; Dautresme, Marianne; Hourmand-Ollivier, Isabelle; Filippi, Céline; Duchamp, Claude; Sibille, Brigitte

    2007-01-01

    Background Understanding of nonalcoholic steatohepatitis (NASH) is hampered by the lack of a suitable model. Our aim was to investigate whether long term high saturated-fat feeding would induce NASH in rats. Methods 21 day-old rats fed high fat diets for 14 weeks, with either coconut oil or butter, and were compared with rats feeding a standard diet or a methionine choline-deficient (MCD) diet, a non physiological model of NASH. Results MCDD fed rats rapidly lost weight and showed NASH features. Rats fed coconut (86% of saturated fatty acid) or butter (51% of saturated fatty acid) had an increased caloric intake (+143% and +30%). At the end of the study period, total lipid ingestion in term of percentage of energy intake was higher in both coconut (45%) and butter (42%) groups than in the standard (7%) diet group. No change in body mass was observed as compared with standard rats at the end of the experiment. However, high fat fed rats were fattier with enlarged white and brown adipose tissue (BAT) depots, but they showed no liver steatosis and no difference in triglyceride content in hepatocytes, as compared with standard rats. Absence of hepatic lipid accumulation with high fat diets was not related to a higher lipid oxidation by isolated hepatocytes (unchanged ketogenesis and oxygen consumption) or hepatic mitochondrial respiration but was rather associated with a rise in BAT uncoupling protein UCP1 (+25–28% vs standard). Conclusion Long term high saturated fat feeding led to increased "peripheral" fat storage and BAT thermogenesis but did not induce hepatic steatosis and NASH. PMID:17313679

  18. Geochemistry of lavas from the Australian-Antarctic Ridge, easternmost Southeast Indian Ridge

    NASA Astrophysics Data System (ADS)

    Park, S.; Langmuir, C. H.; Lin, J.; Kim, S.; Hahm, D.; Michael, P. J.; Baker, E. T.

    2012-12-01

    The intermediate spreading Australian-Antarctic Ridge (AAR), an easternmost extension of the South East Indian Ridge located in the south of Tasmania, is one of the largest unexplored regions of the global mid-ocean ridge system, owing to its remote location and a very limited workable weather window. In early and late 2011, the Korea Polar Research Institute (KOPRI) conducted two surveys of two segments at 160°E (KR1) and 152.5°E (KR2) using the icebreaker Araon, producing a multi-beam map, 48 rock core samples and a MAPR (Miniature Autonomous Plume Recorder) hydrothermal survey. The full spreading rate of the spreading center in this area is 68 mm/yr. The axial depth of KR1 is relatively shallow (~2,000m) and is a first-order segment bounded by two large offset transform faults. The axial morphology of KR1 varies substantially from an axial high plateau (Segment 1) in the west, to a small rift valley (Segment 2), to an axial high with graben (Segment 3), and to a substantial rift valley (Segment 4) in the east. These changes occur in the absence of marked offsets in the ridge, such as overlapping spreading centers. Even so, these segments can be divided still further into shorter scale segments based on small discontinuities in the linearity of the axis and variations in rock chemistry. Small offsets in bathymetry can be associated with large chemical changes, such as between Segments 2 and 3, where incompatible element abundances change by almost a factor of ten. Incompatible trace element ratios for basalts show a regular pattern that is nonetheless not a single gradient. Along Segments 1 and 2, an axial high changes to a modest rift, (La/Sm)N of basalts decreases from 0.9 to 0.5. Then there is an abrupt step in enrichment to (La/Sm)N of 1.5, associated with a shallower depths and the appearance of an off-axis seamount south of the axis. This enrichment persists eastwards and then declines progressively to values of (La/Sm)N of 0.7 in the pronounced rift

  19. Age and position of the sedimentary basin of the Ocoee Supergroup western Blue Ridge tectonic province, southern Appalachians

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Unrug, R.; Unrug, S.; Ausich, W.I.

    The stratigraphic continuity of the Ocoee Supergroup established recently allows one to extrapolate the Paleozoic age of the Walden Creek Group determined on paleontological evidence to the entire Ocoee succession. The Walden Creek Group rocks contain a fossil assemblage of fenestrate bryozoan, algal, trilobite, ostracod, brachiopod and echinozoan fragments and agglutinated foraminifer tests that indicate Silurian or younger Paleozoic age. The fossils occur in carbonate clasts in polymict conglomerates, and debris-flow breccia beds, and in olistoliths of bedded carbonate and shale, and calcarenite turbidite beds. These carbonate lithologies form a minor, but characteristic constituent of the Walden Creek Group. Fossilmore » have been found also in shale and mudstone siliciclastic lithologies of the Walden Creek Group. The fossils are fragmented and poorly preserved because of several cycles of cementation and solution in the carbonate rocks and a pervasive cleavage in the fine-grained siliciclastic rocks. Recently reported Mississippian plant fossils from the Talladega belt indicate widespread occurrence of Middle Paleozoic basins in the Western Blue Ridge. These pull-apart basins formed in the stress field generated by northward movement of Laurentia past the western margin of Gondwana after the Taconian-Famatinian collision in the Ordovician.« less

  20. Coral-gravel storm ridges: examples from the tropical Pacific and Caribbean

    USGS Publications Warehouse

    Richmond, Bruce M.; Morton, Robert A.

    2007-01-01

    Extreme storms in reef environments have long been recognized as a mechanism for depositing ridges of reef-derived coarse clastic sediment. This study revisits the storm ridges formed by Tropical Cyclone Bebe on Funafuti, Tuvalu and Tropical Cyclone Ofa on Upolu, Western Samoa in the South Pacific, and Hurricane Lenny on Bonaire, Netherlands Antilles in the Caribbean. Ridge characteristics produced by these storms include: heights of 1–4 m, widths of 8–50 m, and lengths up to 18 km. The ridges tend to be higher and steeper on their landward margins than on their seaward margins and are composed mostly of re-worked coral rubble derived from reef front settings with smaller amounts of fresh broken coral (5–30%). Characteristics of these modern gravel storm ridges can be used to help identify ancient storm deposits and to differentiate between other coarse-grained deposits such as those created by tsunamis.

  1. Bifurcation of eastward jets induced by mid-ocean ridges and diverging isobaths

    NASA Astrophysics Data System (ADS)

    Shi, Chuan; Chao, Shenn-Yu

    1995-10-01

    A three-dimensional primitive-equation model is employed to investigate how a mid-ocean ridge affects an eastward incoming jet overlying isobaths that diverge eastward. The diverging isobaths contain a major northeastward continental slope and a minor deeper southeastward bottom slope, both with shallow waters to the north. The southwest-northeast trending mid-ocean ridge is placed at about 1700km east of the northeastward continental slope. In the barotropic regime, the diverging isobaths force an initially eastward jet to widen and follow f/h contours after a hydraulic jump. The mid-ocean ridge radiates barotropic Rossby waves, further enhancing the lateral widening of the jet. The northern portion of the jet expands northward and forms a western boundary current along the northeastward continental slope. The bifurcated current system consists of the northeastward flow and the remnant of the original eastward current. When the ridge is removed, the jet diverges but does not bifurcate. In the baroclinic regime, continuous meander and eddy activities reinforce the meridional spreading of the jet and cause greater portion of the jet to diverge northward. Consequently, a stronger western boundary current is formed along the northeastward continental slope. As in the barotropic regime, the mid-ocean ridge exerts its influence upstream by radiating barotropic Rossby waves westward, further enhancing the jet splitting. Among possible applications, the model is particularly relevant to the bifurcation of the Gulf Stream as it passes by the southern tail of the Grand Banks.

  2. Gary Nash: Preeminent Scholar and Committed Educator

    ERIC Educational Resources Information Center

    Symcox, Linda

    2009-01-01

    The author has known Gary Nash as a friend since 1969, but she only began to work with him as a colleague in 1989, when he invited her to join the National Center for History in the Schools (NCHS) as it was just forming. During the seven years she spent as Assistant and then Associate Director of the NCHS, they shared the extraordinary experience…

  3. Nash Equilibria in Noncooperative Predator-Prey Games

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ramos, Angel Manuel; Roubicek, Tomas

    2007-09-15

    A noncooperative game governed by a distributed-parameter predator-prey system is considered, assuming that two players control initial conditions for predator and prey, respectively. Existence of a Nash equilibrium is shown under the condition that the desired population profiles and the environmental carrying capacity for the prey are sufficiently small. A conceptual approximation algorithm is proposed and analyzed. Finally, numerical simulations are performed, too.

  4. Late Quaternary sediment deposition of core MA01 in the Mendeleev Ridge, the western Arctic Ocean: Preliminary results

    NASA Astrophysics Data System (ADS)

    Park, Kwang-Kyu; Kim, Sunghan; Khim, Boo-Keun; Xiao, Wenshen; Wang, Rujian

    2014-05-01

    Late Quaternary deep marine sediments in the Arctic Ocean are characterized by brown layers intercalated with yellowish to olive gray layers (Poore et al., 1999; Polyak et al., 2004). Previous studies reported that the brown and gray layers were deposited during interglacial (or interstadial) and glacial (or stadial) periods, respectively. A 5.5-m long gravity core MA01 was obtained from the Mendeleev Ridge in the western Arctic Ocean by R/V Xue Long during scientific cruise CHINARE-V. Age (~450 ka) of core MA01 was tentatively estimated by correlation of brown layers with an adjacent core HLY0503-8JPC (Adler et al., 2009). A total of 22 brown layers characterized by low L* and b*, high Mn concentration, and abundant foraminifera were identified. Corresponding gray layers are characterized by high L* and b*, low Mn concentration, and few foraminiferal tests. Foraminifera abundance peaks are not well correlated to CaCO3 peaks which occurred with the coarse-grained (>0.063 mm) fractions (i.e., IRD) both in brown and gray layers. IRDs are transported presumably by sea ice for the deposition of brown layers and by iceberg for the deposition of gray layers (Polyak et al., 2004). A strong correlation coefficient (r2=0.89) between TOC content and C/N ratio indicates that the major source of organic matter is terrestrial. The good correlations of CaCO3 content to TOC (r2=0.56) and C/N ratio (r2=0.69) imply that IRDs contain detrital CaCO3 which mainly originated from the Canadian Arctic Archipelago. In addition, high kaolinite/chlorite (K/C) ratios mostly correspond to CaCO3 peaks, which suggests that the fine-grained particles in the Mendeleev Ridge are transported from the north coast Alaska and Canada where Mesozoic and Cenozoic strata are widely distributed. Thus, the Beaufort Gyre, the predominant surface current in the western Arctic Ocean, played an important role in the sediment delivery to the Mendeleev Ridge. It is worthy of note that the TOC and CaCO3 peaks are

  5. Approximation of Nash equilibria and the network community structure detection problem

    PubMed Central

    2017-01-01

    Game theory based methods designed to solve the problem of community structure detection in complex networks have emerged in recent years as an alternative to classical and optimization based approaches. The Mixed Nash Extremal Optimization uses a generative relation for the characterization of Nash equilibria to identify the community structure of a network by converting the problem into a non-cooperative game. This paper proposes a method to enhance this algorithm by reducing the number of payoff function evaluations. Numerical experiments performed on synthetic and real-world networks show that this approach is efficient, with results better or just as good as other state-of-the-art methods. PMID:28467496

  6. Mexican Ridges passive margin foldbelt of western Gulf of Mexico detached along the top of an extensive, Oligocene mass transport complex

    NASA Astrophysics Data System (ADS)

    Fick, A.; Mann, P.

    2016-12-01

    The Mexican Ridges fold-thrust belt (MRFTB) is a 110-210-km-wide and 500-600-km long passive margin, deep-water fold belt fringing the eastern Mexico continental shelf and deepwater western Gulf of Mexico (WGOM). Previous workers determined: 1) that the MRFTB formed in response to multiple gravity sliding events along multiple, Paleogene shale horizons during the Neogene and 2) that down-dip, east-west shortening ranges from 12-22 km in the deep western GOM basin is paired with updip extension of 9-10 km along the Mexican shelf. We have used a grid of 9,440 km's of 2D seismic lines tied to 2 wells to better constrain the detachment underlying the MRFTB. In the northern fold belt, fault detachment and detachment folds in the competent Neogene stratigraphy are cored by a ductile wedge of finer-grained Oligocene sediment ranging in thickness from 0-900 meters. The wedge covers approximately 81,750 km2 and extends 300 kilometers from its onlap onto the Eocene shelf to its downdip pinchout in the deepwater GOM basin. Previous workers have interpreted the Oligocene strata coring the folds to be composed of finer grained sediments with some chaotic seismic facies or homogeneous shales but have not mapped this detachment surface in detail. Our new 2D seismic reflection data tied to wells shows that the basal detachment of the MRFTB is a thickening-landward, wedge of stacked, fine-grained mass transport complexes (MTCs). This Oligocene aged MTC has experienced significant internal deformation in the proximal shelf area while its depositional facies are well preserved in the more distal deepwater areas of the GOM. Elevated pore and fluid pressure in the MTC complex may have contributed to its role as a regional detachment underlying the Mexican Ridges fold-thrust belt along with defining the regional, lobate geometry of the MRFTB.

  7. Murray Ridge on Rim of Endeavour Crater on Mars, False Color

    NASA Image and Video Library

    2013-11-13

    This scene shows the Murray Ridge portion of the western rim of Endeavour Crater on Mars, as seen by NASA Opportunity rover. It is presented in false color to make some differences between materials easier to see.

  8. Western Continental Margin of India - Re-look using potential field data

    NASA Astrophysics Data System (ADS)

    Rajaram, M.; S P, A.

    2008-05-01

    The Western Continental Margin of India (WCMI) evolved as a result of rifting between India and Madagascar that took place during mid Cretaceous (~88Ma).The WCMI is equally important in terms of natural resources as well as research point of view. The major tectonic elements in the western offshore includes the Laxmi and Chagos- Laccadive ridge dividing the WCMI and the adjoining Arabian sea into two basins, Pratap Ridge, Alleppey platform etc. Different theories have been proposed for the evolution of each of these tectonic elements. In the current paper we look at geopotential data on the west coast of India and the western off-shore. The data sets utilized include Satellite derived High Resolution Free Air Gravity data over the off-shore, Bouguer data onland, Champ Satellite Magnetic data, published Marine Magnetic data collected by ONGC, NIO, ground magnetic data over west cost collected by IIG and available aeromagnetic data. From the free air gravity anomaly the structural details of the western offshore can be delineated. The Euler depths of FAG depict deep solutions associated with Pratap Ridge, Comorin Ridge, the west coast fault and the Laxmi Ridge. These may be associated with continental margin and continental fragments. From the aeromagnetic and marine magnetic data it is evident that the West Coast Fault is dissected at several places. The shallow circular feature associated with Bombay High is evident both on the FAG and the analytic signal derived from satellite Magnetic data. The crustal magnetic thickness from MF5 lithospheric model of the Champ appears to suggest that the continental crust extends up to the Chagos- Laccadive ridge. Based on the analysis of these geopotential data sets the various theories for the evolution of the WCMI will be evaluated and these results will be presented.

  9. Gut microbiome composition in lean patients with NASH is associated with liver damage independent of caloric intake: A prospective pilot study.

    PubMed

    Duarte, S M B; Stefano, J T; Miele, L; Ponziani, F R; Souza-Basqueira, M; Okada, L S R R; de Barros Costa, F G; Toda, K; Mazo, D F C; Sabino, E C; Carrilho, F J; Gasbarrini, A; Oliveira, C P

    2018-04-01

    The aim of the study was to compare the gut microbiomes from obese and lean patients with or without NASH to outline phenotypic differences. We performed a cross-sectional pilot study comprising biopsy-proven NASH patients grouped according to BMI. Microbiome DNA was extracted from stool samples, and PCR amplification was performed using primers for the V4 region of the 16S rRNA gene. The amplicons were sequenced using the Ion PGM Torrent platform, and data were analyzed using QIIME software. Macronutrient consumption was analyzed by a 7-day food record. Liver fibrosis ≥ F2 was associated with increased abundance of Lactobacilli (p = 0.0007). NASH patients showed differences in Faecalibacterium, Ruminococcus, Lactobacillus and Bifidobacterium abundance compared with the control group. Lean NASH patients had a 3-fold lower abundance of Faecalibacterium and Ruminococcus (p = 0.004), obese NASH patients were enriched in Lactobacilli (p = 0.002), and overweight NASH patients had reduced Bifidobacterium (p = 0.018). Moreover, lean NASH patients showed a deficiency in Lactobacillus compared with overweight and obese NASH patients. This group also appeared similar to the control group with regard to gut microbiome alpha diversity. Although there were qualitative differences between lean NASH and overweight/obese NASH, they were not statistically significant (p = 0.618). The study limitations included a small sample size, a food questionnaire that collected only qualitative and semi-quantitative data, and variations in group gender composition that may influence differences in FXR signaling, bile acids metabolism and the composition of gut microbiota. Our preliminary finding of a different pathogenetic process in lean NASH patients needs to be confirmed by larger studies, including those with patient populations stratified by sex and dietary habits. Copyright © 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the

  10. Abyssal Upwelling in Mid-Ocean Ridge Fracture Zones

    NASA Astrophysics Data System (ADS)

    Clément, Louis; Thurnherr, Andreas M.

    2018-03-01

    Turbulence in the abyssal ocean plays a fundamental role in the climate system by sustaining the deepest branch of the overturning circulation. Over the western flank of the Mid-Atlantic Ridge in the South Atlantic, previously observed bottom-intensified and tidally modulated mixing of abyssal waters appears to imply a counterintuitive densification of deep and bottom waters. Here we show that inside fracture zones, however, turbulence is elevated away from the seafloor because of intensified downward propagating near-inertial wave energy, which decays below a subinertial shear maximum. Ray-tracing simulations predict a decay of wave energy subsequent to wave-mean flow interactions. The hypothesized wave-mean flow interactions drive a deep flow toward lighter densities of up to 0.6 Sv over the mid-ocean ridge flank in the Brazil Basin, and the same process may also cause upwelling of abyssal waters in other ocean basins with mid-ocean ridges with fracture zones.

  11. Repeat ridge jumps associated with plume-ridge interaction, melt transport, and ridge migration

    NASA Astrophysics Data System (ADS)

    Mittelstaedt, Eric; Ito, Garrett; van Hunen, Jeroen

    2011-01-01

    Repeated shifts, or jumps, of mid-ocean ridge segments toward nearby hot spots can produce large, long-term changes to the geometry and location of the tectonic plate boundaries. Ridge jumps associated with hot spot-ridge interaction are likely caused by several processes including shear on the base of the plate due to expanding plume material as well as reheating of lithosphere as magma passes through it to feed off-axis volcanism. To study how these processes influence ridge jumps, we use numerical models to simulate 2-D (in cross section) viscous flow of the mantle, viscoplastic deformation of the lithosphere, and melt migration upward from the asthenospheric melting zone, laterally along the base of the lithosphere, and vertically through the lithosphere. The locations and rates that magma penetrates and heats the lithosphere are controlled by the time-varying accumulation of melt beneath the plate and the depth-averaged lithospheric porosity. We examine the effect of four key parameters: magmatic heating rate of the lithosphere, plate spreading rate, age of the seafloor overlying the plume, and the plume-ridge migration rate. Results indicate that the minimum value of the magmatic heating rate needed to initiate a ridge jump increases with plate age and spreading rate. The time required to complete a ridge jump decreases with larger values of magmatic heating rate, younger plate age, and faster spreading rate. For cases with migrating ridges, models predict a range of behaviors including repeating ridge jumps, much like those exhibited on Earth. Repeating ridge jumps occur at moderate magmatic heating rates and are the result of changes in the hot spot magma flux in response to magma migration along the base of an evolving lithosphere. The tendency of slow spreading to promote ridge jumps could help explain the observed clustering of hot spots near the Mid-Atlantic Ridge. Model results also suggest that magmatic heating may significantly thin the lithosphere

  12. Nash equilibrium in differential games and the construction of the programmed iteration method

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Averboukh, Yurii V

    This work is devoted to the study of nonzero-sum differential games. The set of payoffs in a situation of Nash equilibrium is examined. It is shown that the set of payoffs in a situation of Nash equilibrium coincides with the set of values of consistent functions which are fixed points of the program absorption operator. A condition for functions to be consistent is given in terms of the weak invariance of the graph of the functions under a certain differential inclusion. Bibliography: 18 titles.

  13. Evidence of recent volcanic activity on the ultraslow-spreading Gakkel ridge.

    PubMed

    Edwards, M H; Kurras, G J; Tolstoy, M; Bohnenstiehl, D R; Coakley, B J; Cochran, J R

    2001-02-15

    Seafloor spreading is accommodated by volcanic and tectonic processes along the global mid-ocean ridge system. As spreading rate decreases the influence of volcanism also decreases, and it is unknown whether significant volcanism occurs at all at ultraslow spreading rates (<1.5 cm yr(-1)). Here we present three-dimensional sonar maps of the Gakkel ridge, Earth's slowest-spreading mid-ocean ridge, located in the Arctic basin under the Arctic Ocean ice canopy. We acquired this data using hull-mounted sonars attached to a nuclear-powered submarine, the USS Hawkbill. Sidescan data for the ultraslow-spreading (approximately 1.0 cm yr(-1)) eastern Gakkel ridge depict two young volcanoes covering approximately 720 km2 of an otherwise heavily sedimented axial valley. The western volcano coincides with the average location of epicentres for more than 250 teleseismic events detected in 1999, suggesting that an axial eruption was imaged shortly after its occurrence. These findings demonstrate that eruptions along the ultraslow-spreading Gakkel ridge are focused at discrete locations and appear to be more voluminous and occur more frequently than was previously thought.

  14. Discovery and Distribution of Black Smokers on the Western Galapagos Spreading Center: Implications for Spatial and Temporal Controls on High Temperature Venting at Ridge/Hotspot Intersections

    NASA Astrophysics Data System (ADS)

    Haymon, R. M.; Anderson, P. G.; Baker, E. T.; Resing, J. A.; White, S. M.; MacDonald, K. C.

    2006-12-01

    flows of visually-similar ages (estimated to be tens-to-hundreds of years old). Possibly a volcanic pulse may have activated the hotspot- affected western GSC, and powered contemporaneous hydrothermal vents that now are waning. It may be that hotspots produce episodes of near-synchronous, extensive ridge volcanism and hydrothermal activity, followed by periods of quiescence. This idea is consistent with: the episodic eruption histories of Hawaii and Iceland; variably anomalous hydrothermal plume incidence (low on RR, SEIR, GSC; high on Mid-Atlantic Ridge near Azores hotspot); models of episodic melt extraction from mantle plumes; and evidence for magma propagation along hotspot-influenced ridges. Our hypothesis potentially can be tested by studies of gene flow between animal communities located on either side of the Galapagos hotspot, and by dating of GSC hydrothermal chimneys and the lava flows on which they are constructed.

  15. Surviving History: Gary Nash and the National Standards

    ERIC Educational Resources Information Center

    Bingham, Marjorie

    2009-01-01

    In this article, the author recalls the first time she met Gary Nash. He came to speak at a Bradley Commission meeting and she was rather surprised to see him appear and to find out that he, along with Charlotte Crabtree, was involved in a National Center for History. She gives three reasons for her surprise which she thinks may tell aspects of…

  16. A Graphical Analysis of the Cournot-Nash and Stackelberg Models.

    ERIC Educational Resources Information Center

    Fulton, Murray

    1997-01-01

    Shows how the Cournot-Nash and Stackelberg equilibria can be represented in the familiar supply-demand graphical framework, allowing a direct comparison with the monopoly, competitive, and industrial organization models. This graphical analysis is represented throughout the article. (MJP)

  17. Woodland clearance alters geomorphic, hydrologic, and pedogenic drivers of ecosystem services: examples from the southern Blue Ridge (USA) and the French western Pyrenees Mountains

    NASA Astrophysics Data System (ADS)

    Leigh, David

    2016-04-01

    The southern Blue Ridge (USA) and French western Pyrenees both are humid-temperate mountains where native woodlands have been cleared on soils formed in residuum and colluvium on hillslopes. Forest removal increased rates of erosion and sediment yield that drove both negative and positive ecosystem services. For example, the supportive ecosystem service of soil formation was diminished on eroded hillslopes, but may have been enhanced by accumulation of sediment on bottomlands far downstream from the highland source areas. Negative effects on provisional ecosystem services (e.g. water supply) resulted in aggraded bottomlands by increasing the depth to the water table. Legacy effects linger on hillslopes that reforested (diminished soil properties), and ongoing alteration of pedogenic and hydrologic processes affect pastures that persisted from cleared woodlands. Beyond those general similarities, pastures of the two regions exhibit very different pedogenic pathways and ecosystem service outcomes. Soils of the Blue Ridge pastures adhere to a typical degradation scenario of erosion, compaction, and reduced infiltration capacities, whereas Pyrenees pastures exhibit soil qualities trending in the opposite direction and arguably now are better quality soils than their forested predecessors. Major differences in temporal duration and management styles apparently have led to such contrasts in soil quality. The Blue Ridge pastures are only tens to hundreds of years old, whereas Pyrenees pastures are thousands of years old. Blue Ridge pastures are maintained by mowing with tractors and year-round grazing primarily with beef cattle, whereas Pyrenees pastures (outfields) lack tractors and are only grazed seasonally (summer), primarily with sheep. Fire is rarely used as a management tool in the Blue Ridge, while Pyrenees pastures frequently are burned. Such management practices, and their influence on pedogenic and hydrologic processes, generally have resulted in negative

  18. Factors predicting non-alcoholic steatohepatitis (NASH) and advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).

    PubMed

    Tasneem, Abbas Ali; Luck, Nasir Hassan; Majid, Zain

    2018-04-01

    Introduction To determine the factors predicting non-alcoholic steatohepatitis (NASH) and advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Methodology All patients aged >18 years and having a fatty liver on abdominal ultrasound (US), presenting from January 2011 to January 2017, were included. A liver biopsy was performed on all the patients. Results Of 96 patients undergoing liver biopsy for non-alcoholic fatty liver disease (NAFLD), 76 (79.2%) were men. On liver US, diffuse fatty liver (DFL) was noted in 68 (70.8%) patients. Liver biopsy showed non-alcoholic steatohepatitis (NASH) in 78 (81.3%) patients. Factors associated with NASH were male gender, body mass index (BMI) > 27 kg/m 2 , DFL and raised alanine aminotransferase (ALT). A GULAB score (based on gender, US liver findings, lipid (fasting) levels, ALT level and BMI) of ≥5 predicted NASH with 82.05% sensitivity. Factors associated with advanced fibrosis in NAFLD were age >40 years, diabetes mellitus, AST/ALT ratio > 1 and raised GGT. Conclusion NASH is common in patients with male gender, high BMI, DFL on liver US, raised ALT and GULAB score ≥5.

  19. The Cocos Ridge drives collision of Panama with northwestern South America

    NASA Astrophysics Data System (ADS)

    LaFemina, Peter; Govers, Rob; Mora-Paez, Hector; Geirsson, Halldor; Cmacho, Eduardo

    2015-04-01

    The collision of the Panamanian isthmus with northwestern South America is thought to have initiated as early as Oligocene - Miocene time (23-25 Ma) based on geologic and geophysical data and paleogeographic reconstructions. This collision was driven by eastward-directed subduction beneath northwestern South America. Cocos - Caribbean convergence along the Middle America Trench, and Nazca - Caribbean oblique convergence along the South Panama Deformed Belt have resulted in complex deformation of the southwestern Caribbean since Miocene - Pliocene time. Subduction and collision of the aseismic Cocos Ridge is thought to have initiated <3.5 Ma and has been linked to: 1) late Miocene-Pliocene cessation of volcanism and uplift of the Cordillera de Talamanca; 2) Quaternary migration of the volcanic arc toward the back-arc; 3) Quaternary to present deformation within the Central Costa Rica Deformed Belt; 4) Quaternary to present shortening across the fore-arc Fila Costeña fold and thrust belt and back-arc North Panama Deformed Belt (NPDB); 5) Quaternary to present outer fore-arc uplift of Nicoya Peninsula above the seamount domain, and the Osa and Burica peninsulas above the ridge; and 6) Pleistocene to present northwestward motion of the Central American Fore Arc (CAFA) and northeastward motion of the Panama Region. We investigate the geodynamic effects of Cocos Ridge collision on motion of the Panama Region with a new geodynamic model. The model is compared to a new 1993-2015 GPS-derived three-dimensional velocity field for the western Caribbean and northwestern South America. Specifically, we test the hypotheses that the Cocos Ridge is the main driver for upper plate deformation in the western Caribbean. Our models indicate that Cocos Ridge collision drives northwest-directed motion of the CAFA and the northeast-directed motion of the Panama Region. The Panama Region is driven into the Caribbean across the NPDB and into northwestern South America, which is also

  20. Preliminary appraisal of gravity and magnetic data of Syncline Ridge, western Yucca Flat, Nevada Test Site, Nye County, Nevada

    USGS Publications Warehouse

    Ponce, David A.; Hanna, William F.

    1982-01-01

    A gravity and magnetic study of the Syncline Ridge area was conducted as part of an investigation of argillite rocks of the Eleana Formation under consideration as a medium for the possible storage of high-level radioactive waste. Bouguer gravity anomaly data, viewed in light of densities obtained by gamma-gamma logs and previous work of D. L. Healey (1968), delineate two regions of steep negative gradient where Cenozoic rocks and sediments are inferred to abruptly thicken: (1) the western third of the study area where Tertiary volcanic rocks are extensively exposed and (2) the northeast corner of the area where Quaternary alluvium is exposed and where volcanic rocks are inferred to occur at depth. In the remainder of the area, a region extending contiguously from Mine Mountain northwestward through Syncline Ridge to the Eleana Range, the gravity data indicate that the Eleana Formation, where not exposed, is buried at depths of less than about 200 m, except in a limited area of exposed older Paleozoic rocks on Mine Mountain. Quaternary alluvium and Tertiary volcanic rocks are inferred to occur in this region as veneers or shallow dishes of deposit on Tippipah Limestone or Eleana Formation. Low-level aeromagnetic anomaly data, covering the western two-thirds of the study area, delineate relatively magnetic tuff units within the Tertiary volcanic rocks and provide a very attractive means for distinguishing units of normal polarization from units of reversed polarization. If used in conjunction with results of previous magnetization studies of G. D. Bath (1968), the low-level survey may prove to be an effective tool for mapping specific tuff members in the volcanic terrane. The important question of the feasibility of discriminating high-quartz argillite from low-quartz argillite of the Eleana Formation using surface gravity data remains unresolved. If the more highly competent, denser, high-quartz phase should occur as stratigraphic units many tens of meters thick

  1. Horse Rock Ridge Research Natural Area: guidebook supplement 27.

    Treesearch

    Alan B. Curtis

    2003-01-01

    Horse Rock Ridge Research Natural Area (HRR RNA) was established in June 1995 to protect the best remaining example of a grassy “bald” (treeless area) on the western margin of the Cascade Range and its associated botanical, wildlife, and scenic values. This bald is surrounded by old-growth Pseudotsuga menziesii/Tsuga heterophylla...

  2. Plume-ridge interaction: Shaping the geometry of mid-ocean ridges

    NASA Astrophysics Data System (ADS)

    Mittelstaedt, Eric L.

    Manifestations of plume-ridge interaction are found across the ocean basins. Currently there are interactions between at least 21 hot spots and nearby ridges along 15--20% of the global mid-ocean ridge network. These interactions produce a number of anomalies including the presence of elevated topography, negative gravity anomalies, and anomalous crustal production. One form of anomalous crustal production is the formation of volcanic lineaments between hotspots and nearby mid-ocean ridges. In addition, observations indicate that mantle plumes tend to "capture" nearby mid-ocean ridges through asymmetric spreading, increased ridge propagation, and discrete shifts of the ridge axis, or ridge jumps. The initiation of ridge jumps and the formation of off-axis volcanic lineaments likely involve similar processes and may be closely related. In the following work, I use theoretical and numerical models to quantify the processes that control the formation of volcanic lineaments (Chapter 2), the initiation of mid-ocean ridge jumps associated with lithospheric heating due to magma passing through the plate (Chapter 3), and the initiation of jumps due to an upwelling mantle plume and magmatic heating governed by melt migration (Chapter 4). Results indicate that lineaments and ridge jumps associated with plume-ridge interaction are most likely to occur on young lithosphere. The shape of lineaments on the seafloor is predicted to be controlled by the pattern of lithospheric stresses associated with a laterally spreading, near-ridge mantle plume. Ridge jumps are likely to occur due to magmatic heating alone only in lithosphere ˜1Myr old, because the heating rate required to jump increases with spreading rate and plate age. The added effect of an upwelling plume introduces competing effects that both promote and inhibit ridge jumps. For models where magmatic heating is controlled by melt migration, repeat ridge jumps are predicted to occur as the plume and ridge separate, but

  3. Critical Realism and Statistical Methods--A Response to Nash

    ERIC Educational Resources Information Center

    Scott, David

    2007-01-01

    This article offers a defence of critical realism in the face of objections Nash (2005) makes to it in a recent edition of this journal. It is argued that critical and scientific realisms are closely related and that both are opposed to statistical positivism. However, the suggestion is made that scientific realism retains (from statistical…

  4. Beach impacts of shore-parallel breakwaters backing offshore submerged ridges, Western Mediterranean Coast of Egypt.

    PubMed

    Iskander, Moheb M; Frihy, Omran E; El Ansary, Ahmed E; El Mooty, Mohamed M Abd; Nagy, Hossam M

    2007-12-01

    Seven breakwaters were constructed behind offshore submerged ridges to create a safe area for swimming and recreational activities west of Alexandria on the Mediterranean coast of Egypt. Morphodynamic evaluation was based on the modified Perlin and Dean numerical model (ImSedTran-2D) combined with successive shoreline and beach profile surveys conducted periodically between April 2001 and May 2005. Results reveal insignificant morphologic changes behind the detached breakwaters with slight coastline changes at the down and up-drift beaches of the examined breakwaters (+/-10 m). These changes are associated with salient accretion (20-7 0m) in the low-energy leeside of such structures. Concurrent with this sand accretion is the accumulation of a large amount of benthic algae (Sargassum) in the coastal water of the shadow area of these structures, which in turn have adverse effects on swimmers. Practical measures proposed in this study have successfully helped in mitigating such accumulation of algae in the recreation leeside of the breakwaters. The accumulation of Sargassum, together with the virtual insignificant changes in the up-drift and down-drifts of these structures, is a direct response to both coastal processes and the submerged carbonate ridges. Coastal processes encompass reversal of the directions of long-shore sand transport versus shoreline orientation, the small littoral drift rate and sand deficiency of the littoral zone. The beach response to the breakwaters together with the submerged ridges has also been confirmed by applying the ImSedTran-2D model. Results indicate that submerged ridges play a principal role in the evolution of beach morphology along the west coast of Alexandria. Although the study area is exposed to more than 70% wave exposures, the morphodynamic behavior of the beaches indicates that the submerged ridges act in a similar way as an additional natural barrier together with the artificial detached structures.

  5. Follow-up CT findings of tamoxifen-induced non-alcoholic steatohepatitis (NASH) of breast cancer patients treated with bezafibrate.

    PubMed

    Ogawa, Yasuhiro; Murata, Yoriko; Saibara, Toshiji; Nishioka, Akihito; Kariya, Shinji; Yoshida, Shoji

    2003-01-01

    One-third of the breast cancer patients who underwent tamoxifen intake showed less than 0.9 of their liver/spleen CT (computed tomography) ratio on their annual CT study, and were diagnosed as having fatty liver (hepatic steatosis). Among them, patients who showed a lower liver/spleen CT ratio of less than 0.5 were recommended to undergo needle biopsy of the liver in order to obtain histopathological confirmation of non-alcoholic steatohepatitis (NASH), with 15 patients undergoing needle biopsy of the liver. As a result, 14 out of the 15 patients were diagnosed as having NASH, and these patients were additionally administered bezafibrate in order to prevent possible progressive changes of NASH into liver cirrhosis. In this study, we show the changes of follow-up CT findings of 6 patients with histopathologically-proven NASH who continued to undergo bezafibrate intake after the diagnosis of NASH. Two patients showed almost complete improvement as indicated by the liver/spleen CT ratio several months after completion of a tamoxifen intake of 5 years, and another 3 showed partial improvement on their liver/spleen CT ratio by bezafibrate intake in spite of continuing tamoxifen intake. Another patient with diabetes mellitus (type II) showed a continually decreasing liver/spleen CT ratio during adjuvant tamoxifen in spite of bezafibrate intake. Therefore, we concluded that the progression of NASH could be prevented by bezafibrate without any interruption of adjuvant tamoxifen treatment. For patients with diabetes mellitus, critical follow-up using CT study and laboratory tests is considered essential.

  6. Cool-Season Moisture Delivery and Multi-Basin Streamflow Anomalies in the Western United States

    NASA Astrophysics Data System (ADS)

    Malevich, Steven B.

    Widespread droughts can have a significant impact on western United States streamflow, but the causes of these events are not fully understood. This dissertation examines streamflow from multiple western US basins and establishes the robust, leading modes of variability in interannual streamflow throughout the past century. I show that approximately 50% of this variability is associated with spatially widespread streamflow anomalies that are statistically independent from streamflow's response to the El Nino-Southern Oscillation (ENSO). The ENSO-teleconnection accounts for approximately 25% of the interannual variability in streamflow, across this network. These atmospheric circulation anomalies associated with the most spatially widespread variability are associated with the Aleutian low and the persistent coastal atmospheric ridge in the Pacific Northwest. I use a watershed segmentation algorithm to explicitly track the position and intensity of these features and compare their variability to the multi-basin streamflow variability. Results show that latitudinal shifts in the coastal atmospheric ridge are more strongly associated with streamflow's north-south dipole response to ENSO variability while more spatially widespread anomalies in streamflow most strongly relate to seasonal changes in the coastal ridge intensity. This likely reflects persistent coastal ridge blocking of cool-season precipitation into western US river basins. I utilize the 35 model runs of the Community Earth System Model Large Ensemble (CESMLE) to determine whether the model ensemble simulates the anomalously strong coastal ridges and extreme widespread wintertime precipitation anomalies found in the observation record. Though there is considerable bias in the CESMLE, the CESMLE runs simulate extremely widespread dry precipitation anomalies with a frequency of approximately one extreme event per century during the historical simulations (1920 - 2005). These extremely widespread dry events

  7. Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation

    PubMed Central

    Reid, D. T.; Reyes, J. L.; McDonald, B. A.; Vo, T.; Reimer, R. A.; Eksteen, B.

    2016-01-01

    Non-alcoholic fatty liver disease has become the leading liver disease in North America and is associated with the progressive inflammatory liver disease non-alcoholic steatohepatitis (NASH). Considerable effort has been made to understand the role of resident and recruited macrophage populations in NASH however numerous questions remain. Our goal was to characterize the dynamic changes in liver macrophages during the initiation of NASH in a murine model. Using the methionine-choline deficient diet we found that liver-resident macrophages, Kupffer cells were lost early in disease onset followed by a robust infiltration of Ly-6C+ monocyte-derived macrophages that retained a dynamic phenotype. Genetic profiling revealed distinct patterns of inflammatory gene expression between macrophage subsets. Only early depletion of liver macrophages using liposomal clodronate prevented the development of NASH in mice suggesting that Kupffer cells are critical for the orchestration of inflammation during experimental NASH. Increased understanding of these dynamics may allow us to target potentially harmful populations whilst promoting anti-inflammatory or restorative populations to ultimately guide the development of effective treatment strategies. PMID:27454866

  8.  The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women.

    PubMed

    Simental-Mendía, Luis E; Simental-Mendía, Esteban; Rodríguez-Hernández, Heriberto; Rodríguez-Morán, Martha; Guerrero-Romero, Fernando

    2016-01-01

     Introduction and aim. Given that early identification of non-alcoholic fatty liver disease (NAFLD) is an important issue for primary prevention of hepatic disease, the objectives of this study were to evaluate the efficacy of the product of triglyceride and glucose levels (TyG) for screening simple steatosis and non-alcoholic steatohepatitis (NASH) in asymptomatic women, and to compare its efficacy vs. other biomarkers for recognizing NAFLD. Asymptomatic women aged 20 to 65 years were enrolled into a cross-sectional study. The optimal values of TyG, for screening simple steatosis and NASH were established on a Receiver Operating Characteristic scatter plot; the sensitivity, specificity, and likelihood ratios of TyG index were estimated versus liver biopsy. According sensitivity and specificity, the efficacy of TyG was compared versus the well-known clinical biomarkers for recognizing NAFLD. A total of 50 asymptomatic women were enrolled. The best cutoff point of TyG for screening simple steatosis was 4.58 (sensitivity 0.94, specificity 0.69); in addition, the best cutoff point of TyG index for screening NASH was 4.59 (sensitivity 0.87, specificity 0.69). The positive and negative likelihood ratios were 3.03 and 0.08 for simple steatosis, and 2.80 and 0.18 for NASH. As compared versus SteatoTest, NashTest, Fatty liver index, and Algorithm, the TyG showed to be the best test for screening. TyG has high sensitivity and low negative likelihood ratio; as compared with other clinical biomarkers, the TyG showed to be the best test for screening simple steatosis and NASH.

  9. Hotspot-Ridge Interaction: Shaping the Geometry of Mid-Ocean Ridges

    NASA Astrophysics Data System (ADS)

    Mittelstaedt, E.; Ito, G.

    2004-12-01

    Surface manifestations of hotspot-ridge interaction include geochemical anomalies, elevated ridge topography, negative gravity anomalies, off-axis volcanic lineaments, and ridge reorganization events. The last of these is expressed as either "captured" ridge segments due to asymmetric spreading, such as at the Galapagos, or as discrete jumps of the ridge axis toward the hotspot, such as at the Iceland, Tristan de Cuhna, Discovery, Shona, Louisville, Kerguelen, and Reunion hotspots. Mid-ocean ridge axis reorganizations through discrete jumps will cause variations in local volcanic patterns, lead to changes in overall plate shape and ridge axis morphology, and alter local mantle flow patterns. It has been proposed that discrete ridge jumps are a product of interaction between the lithosphere and a mantle plume. We examine this hypothesis using thin plate theory coupled with continuum damage mechanics to calculate the two-dimensional (plan-view) pattern of depth-integrated stresses in a plate of varying thickness with weakening due to volcanism at the ridge and above the plume center. Forces on the plate include plume shear, plate parallel gravitational forces due to buoyant uplift, and a prescribed velocity of plate motion along the edges of the model. We explore these forces and the effect of damage as mechanisms that may be required to predict ridge jumps.

  10. Information Structures in Nash and Leader-Follower Strategies.

    DTIC Science & Technology

    1981-01-01

    OICkASSIPICATION/ OOWNGRAOING IS. OISTNIIIUTION STATEMINT (ao tD. esPort ) * Approved for public release; distribution unlimited. 17. DISTRIBUTION STATEMENT...problems and two market models of duopoly ith this type of information structure are extensively analyzed and examined. DO jAN7, 1473 EDIION OF NV SS IS...information 3 structure is employed in both Nash games and optimal coordination problems and two market models of duopoly with this type of information

  11. On Nash Equilibrium and Evolutionarily Stable States That Are Not Characterised by the Folk Theorem

    PubMed Central

    Li, Jiawei; Kendall, Graham

    2015-01-01

    In evolutionary game theory, evolutionarily stable states are characterised by the folk theorem because exact solutions to the replicator equation are difficult to obtain. It is generally assumed that the folk theorem, which is the fundamental theory for non-cooperative games, defines all Nash equilibria in infinitely repeated games. Here, we prove that Nash equilibria that are not characterised by the folk theorem do exist. By adopting specific reactive strategies, a group of players can be better off by coordinating their actions in repeated games. We call it a type-k equilibrium when a group of k players coordinate their actions and they have no incentive to deviate from their strategies simultaneously. The existence and stability of the type-k equilibrium in general games is discussed. This study shows that the sets of Nash equilibria and evolutionarily stable states have greater cardinality than classic game theory has predicted in many repeated games. PMID:26288088

  12. Ridge-flank crustal microbiology investigated with long-term borehole observatories

    NASA Astrophysics Data System (ADS)

    Orcutt, B. N.; Bach, W.; Becker, K.; Edwards, K. J.; Fisher, A. T.; Haddad, A.; Hulme, S.; Teske, A.; Toner, B.; Wheat, C. G.

    2011-12-01

    The ridge flank environment represents an important habitat for microbial life on Earth, considering its size and chemical disequilibria between circulating fluids and rocks. However, the potential for this habitat to harbor life, and the characteristics that such life might have, are poorly known at present. Furthermore, the interactions of microbial communities across deep sediment-basement interfaces are not well-characterized. Subseafloor borehole observatories provide a novel platform for sampling and monitoring the microbiology of the crustal ridge flank environment. We present current results from a series of subsurface microbial colonization experiments using borehole observatories on the eastern flank of the Juan de Fuca Ridge, as well as analysis of samples collected on a transect away from a seawater-recharging seamount on this ridge flank. These results are compared to the microbiology of observatories installed in the Costa Rica Rift flank with similar fluid composition and temperatures (i.e. anoxic and warm). We will also discuss on-going experiments on the western-flank of the Mid-Atlantic Ridge, where formation fluids in basement are oxic and cool. Results from these experiments represent some of the extremes in crustal fluid conditions, paving the way for additional studies that are needed to address the importance of this biome as a carbon reservoir and a mechanism for crustal alteration.

  13. Specific features of basalts from the western part of Andrew Bain Fault, Southwest Indian Ridge

    NASA Astrophysics Data System (ADS)

    Peyve, A. A.; Skolotnev, S. G.

    2017-12-01

    This paper reports original data on the composition of volcanic rocks in the western part of the Andrew Bain Fault of the South-West Indian Ridge obtained in the 23rd voyage of R/V Akademik Nikolai Strakhov. In accordance with high La/Th and low Nb/U ratios, the basalt compositions of stations S2317, S2318, and S2330 could result from melting of the DM-type source with HIMU traces. Meanwhile, the enriched samples of station S2326 correspond to a mantle source with a considerable contribution of recycled sediments (EM). Sample S2326/35, which is composed of a melt almost completely depleted in EM material, corresponds to the volcanic rocks of the Marion and Prince Edward islands. The obtained and available data on the SWIR segment from Bouvet Island to Andrew Bain Fault are indicative of small mantle heterogeneities in this region. Two possible variants of their origin are considered: either preservation of the enriched material fragments in the depleted mantle during the split of Gondwana or "contamination" of the mantle with plume material with the formation of vein irregularities before opening of the ocean in this region. In the latter case, the plume material could cover a huge area not constrained by the young plume magmatism regions on Bouvet, Marion, and Prince Edward islands.

  14. Docosahexaenoic Acid Attenuates Hepatic Inflammation, Oxidative Stress, and Fibrosis without Decreasing Hepatosteatosis in a Ldlr−/− Mouse Model of Western Diet-Induced Nonalcoholic Steatohepatitis123

    PubMed Central

    Depner, Christopher M.; Philbrick, Kenneth A.; Jump, Donald B.

    2013-01-01

    The incidence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) has increased in parallel with the incidence of obesity. While both NAFLD and NASH are characterized by hepatosteatosis, NASH is characterized by hepatic damage, inflammation, oxidative stress, and fibrosis. We previously reported that feeding Ldlr−/− mice a high-fat, high-cholesterol diet containing menhaden oil attenuated several markers of NASH, including hepatosteatosis, inflammation, and fibrosis. Herein, we test the hypothesis that DHA [22:6 (n-3)] is more effective than EPA [20:5 (n-3)] at preventing Western diet (WD)-induced NASH in Ldlr−/− mice. Mice were fed the WD supplemented with either olive oil (OO), EPA, DHA, or EPA + DHA for 16 wk. WD + OO feeding induced a severe NASH phenotype, characterized by robust hepatosteatosis, inflammation, oxidative stress, and fibrosis. Whereas none of the C20–22 (n-3) fatty acid treatments prevented WD-induced hepatosteatosis, all 3 (n-3) PUFA-containing diets significantly attenuated WD-induced inflammation, fibrosis, and hepatic damage. The capacity of dietary DHA to suppress hepatic markers of inflammation (Clec4F, F4/80, Trl4, Trl9, CD14, Myd88), fibrosis (Procol1α1, Tgfβ1), and oxidative stress (NADPH oxidase subunits Nox2, p22phox, p40phox, p47phox, p67phox) was significantly greater than dietary EPA. The effects of DHA on these markers paralleled DHA-mediated suppression of hepatic Fads1 mRNA abundance and hepatic arachidonic acid content. Because DHA suppression of NASH markers does not require a reduction in hepatosteatosis, dietary DHA may be useful in combating NASH in obese humans. PMID:23303872

  15. Ridge: a computer program for calculating ridge regression estimates

    Treesearch

    Donald E. Hilt; Donald W. Seegrist

    1977-01-01

    Least-squares coefficients for multiple-regression models may be unstable when the independent variables are highly correlated. Ridge regression is a biased estimation procedure that produces stable estimates of the coefficients. Ridge regression is discussed, and a computer program for calculating the ridge coefficients is presented.

  16. Remediating Language Deficient/Dyslexic College Students: An Interview with Robert Nash.

    ERIC Educational Resources Information Center

    Lundquist, Arlene J.; Nash, Robert

    1988-01-01

    Robert Nash responds to questions concerning his personal and professional background, the Simultaneous Multisensory Instructional Procedure for Teaching the Complete Sound Structure of the Language, problems associated with dyslexia, the social/emotional impact of learning disabilities, and the University of Wisconsin's Project Success for…

  17. 77 FR 10553 - Match-E-Be-Nash-She-Wish Band of Pottawatomi Indians (Gun Lake)-Amendment to Liquor Beverage...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Match-E-Be-Nash-She-Wish Band of Pottawatomi Indians (Gun Lake)-- Amendment to Liquor Beverage Control Ordinance AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice SUMMARY: This notice publishes the amendments to the Match-E-Be-Nash- She-Wish...

  18. Hydrothermal plume anomalies over the southwest Indian ridge: magmatic control

    NASA Astrophysics Data System (ADS)

    Yue, X.; Li, H.; Tao, C.; Ren, J.; Zhou, J.; Chen, J.; Chen, S.; Wang, Y.

    2017-12-01

    Here we firstly reported the extensive survey results of the hydrothermal activity along the ultra-slow spreading southwest Indian ridge (SWIR). The study area is located at segment 27, between the Indomed and Gallieni transform faults, SWIR. The seismic crustal thickness reaches 9.5km in this segment (Li et al., 2015), which is much thicker than normal crustal. The anomaly thickened crust could be affected by the Crozet hotspot or highly focused melt delivery from the mantle. The Duanqiao hydrothermal field was reported at the ridge valley of the segment by Tao et al (2009). The Deep-towed Hydrothermal Detection System (DHDS) was used to collect information related with hydrothermal activity, like temperature, turbidity, oxidation-reduction potential (ORP) and seabed types. There are 15 survey lines at the interval of 2 to 3 km which are occupied about 1300 km2 in segment 27. After processing the raw data, including wiping out random noise points, 5-points moving average processing and subtracting the ambient, we got anomalous Nephelometric Turbidity Units values (ΔNTU). And dE/dt was used to identify the ORP anomalous as the raw data is easily influenced by electrode potentials drifting (Baker et al., 2016). According to the results of water column turbidity and ORP distributions, we confirmed three hydrothermal anomaly fields named A1, A2 and A3. The three fields are all located in the western part of the segment. The A1 field lies on the ridge valley, west side of Duanqiao field. The A2 and A3 field lie on the northern and southern of the ridge valley, respectively. We propose that recent magmatic activity probably focus on the western part of segment 27.And the extensive distribution of hydrothermal plume in the segment is the result of the discrete magma intrusion. References Baker E T, et al. How many vent fields? New estimates of vent field populations on ocean ridges from precise mapping of hydrothermal discharge locations. EPSL, 2016, 449:186-196. Li J

  19. Unexpected HIMU-type late-stage volcanism on the Walvis Ridge

    NASA Astrophysics Data System (ADS)

    Homrighausen, S.; Hoernle, K.; Geldmacher, J.; Wartho, J.-A.; Hauff, F.; Portnyagin, M.; Werner, R.; van den Bogaard, P.; Garbe-Schönberg, D.

    2018-06-01

    Volcanic activity at many oceanic volcanoes, ridges and plateaus often reawakens after hiatuses of up to several million years. Compared to the earlier magmatic phases, this late-stage (rejuvenated/post-erosional) volcanism is commonly characterized by a distinct geochemical composition. Late-stage volcanism raises two hitherto unanswered questions: Why does volcanism restart after an extended hiatus and what is the origin of this volcanism? Here we present the first 40Ar/39Ar age and comprehensive trace element and Sr-Nd-Pb-Hf isotopic data from seamounts located on and adjacent to the Walvis Ridge in the South Atlantic ocean basin. The Walvis Ridge is the oldest submarine part of the Tristan-Gough hotspot track and is famous as the original type locality for the enriched mantle one (EM I) end member. Consistent with the bathymetric data, the age data indicates that most of these seamounts are 20-40 Myr younger than the underlying or nearby Walvis Ridge basement. The trace element and isotope data reveal a distinct compositional range from the EM I-type basement. The composition of the seamounts extend from the St. Helena HIMU (high time-integrated 238U/204Pb mantle with radiogenic Pb isotope ratios) end member to an enriched (E) Mid-Ocean-Ridge Basalt (MORB) type composition, reflecting a two-component mixing trend on all isotope diagrams. The EMORB end member could have been generated through mixing of Walvis Ridge EM I with normal (N) MORB source mantle, reflecting interaction of Tristan-Gough (EM I-type) plume melts with the upper mantle. The long volcanic quiescence and the HIMU-like geochemical signature of the seamounts are unusual for classical hotspot related late-stage volcanism, indicating that these seamounts are not related to the Tristan-Gough hotspot volcanism. Two volcanic arrays in southwestern Africa (Gibeon-Dicker Willem and Western Cape province) display similar ages to the late-stage Walvis seamounts and also have HIMU-like compositions

  20. Southern high latitude squat lobsters II: description of Uroptychus macquariae sp. nov. from Macquarie Ridge.

    PubMed

    Schnabel, Kareen E; Burghardt, Ingo; Ahyong, Shane T

    2017-11-23

    Squat lobsters have only recently been recorded from the Macquarie Ridge, which extends south between New Zealand and Antarctica. Among these, Uroptychus insignis (Henderson, 1885) was recorded for the first time outside the western Indian Ocean, exhibiting only subtle morphological differences. Reexamination of the Macquarie Ridge and Indian Ocean specimens attributed to U. insignis using morphological and molecular data revealed the Macquarie Ridge form to represent a separate species. Subtle but consistent morphological differences are evident and partial CO1 sequence data indicates that the specimens collected on Macquarie Ridge differ from those collected in the Indian Ocean by more than 7%. The Macquarie Ridge species is described herein as Uroptychus macquariae n.sp. Subtle morphological differences between the new species and U. insignis are discussed.

  1. Complex Tectono-Magmatic Interaction along the George V Transform Fault, South-East Indian Ridge, 140°E, and Implications for Mantle Dynamics

    NASA Astrophysics Data System (ADS)

    Briais, A.; Ruellan, E.; Ceuleneer, G.; Maia, M.

    2017-12-01

    The 300 km-offset George V Transform Fault (TF) is the westernmost of the major, right-stepping transform faults that offset the South-East Indian Ridge between 140°E and 155°E. All these TFs have multiple shear zones with intra-transform ridge segments (ITRS), mostly unmapped yet. We present the results of the analysis of geophysical and petrological data collected during the STORM cruise (South Tasmania Ocean Ridge and Mantle). The data cover the western shear zone and part of two ITRSs. They reveal a complex interaction between tectonic processes at the plate boundary and near-axis volcanic activity along and across the transform fault. The western TF shear zone consists of two segments offset by a 50 km-long, 15 km-wide, up to 2000 m-high serpentinite massif. We infer that the massif is a push-up resulting from transpression along the transform, due to the lengthening of the western ITRS, with a mechanism similar to the processes currently uplifting the mylonitic massif along the St. Paul TF in the Equatorial Atlantic (1). The western ITRS is relatively shallow and magmatically robust, which is unexpected in a TF system. The bathymetric and backscatter maps also reveal a series of recent off-axis oblique volcanic ridges. Rocks dredged on one of these ridges consist of picrites (i.e. basalts rich in olivine phenocrysts). These observations suggest that the TF there is not magma starved like many mid-ocean ridge transforms, but is the locus of significant primitive melt supply. Such an unexpected production of high-Mg melt might be related to the presence of a mantle thermal anomaly beneath the easternmost SEIR, and/or to a western flow of mantle across the TF. *STORM cruise scientific party: A. Briais, F. Barrere, C. Boulart, D. Brunelli, G. Ceuleneer, N. Ferreira, B. Hanan, C. Hémond, S. Macleod, M. Maia, A. Maillard, S. Merkuryev, S.H. Park, S. Révillon, E. Ruellan, A. Schohn, S. Watson, and Y.S. Yang. (1) Maia et al. 2016 Nature Geo. doi:10.1038/ngeo2759

  2. Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH.

    PubMed

    Ioannou, George N; Van Rooyen, Derrick M; Savard, Christopher; Haigh, W Geoffrey; Yeh, Matthew M; Teoh, Narci C; Farrell, Geoffrey C

    2015-02-01

    Cholesterol crystals form within hepatocyte lipid droplets in human and experimental nonalcoholic steatohepatitis (NASH) and are the focus of crown-like structures (CLSs) of activated Kupffer cells (KCs). Obese, diabetic Alms1 mutant (foz/foz) mice were a fed high-fat (23%) diet containing 0.2% cholesterol for 16 weeks and then assigned to four intervention groups for 8 weeks: a) vehicle control, b) ezetimibe (5 mg/kg/day), c) atorvastatin (20 mg/kg/day), or d) ezetimibe and atorvastatin. Livers of vehicle-treated mice developed fibrosing NASH with abundant cholesterol crystallization within lipid droplets calculated to extend over 3.3% (SD, 2.2%) of liver surface area. Hepatocyte lipid droplets with prominent cholesterol crystallization were surrounded by TNFα-positive (activated) KCs forming CLSs (≥ 3 per high-power field). KCs that formed CLSs stained positive for NLRP3, implicating activation of the NLRP3 inflammasome in response to cholesterol crystals. In contrast, foz/foz mice treated with ezetimibe and atorvastatin showed near-complete resolution of cholesterol crystals [0.01% (SD, 0.02%) of surface area] and CLSs (0 per high-power field), with amelioration of fibrotic NASH. Ezetimibe or atorvastatin alone had intermediate effects on cholesterol crystallization, CLSs, and NASH. These findings are consistent with a causative link between exposure of hepatocytes and KCs to cholesterol crystals and with the development of NASH possibly mediated by NLRP3 activation.

  3. Geology along the Blue Ridge Parkway in Virginia

    USGS Publications Warehouse

    Carter, Mark W.; Southworth, C. Scott; Tollo, Richard P.; Merschat, Arthur J.; Wagner, Sara; Lazor, Ava; Aleinikoff, John N.

    2017-01-01

    Detailed geologic mapping and new SHRIMP (sensitive high-resolution ion microprobe) U-Pb zircon, Ar/Ar, Lu-Hf, 14C, luminescence (optically stimulated), thermochronology (fission-track), and palynology reveal the complex Mesoproterozoic to Quaternary geology along the ~350 km length of the Blue Ridge Parkway in Virginia. Traversing the boundary of the central and southern Appalachians, rocks along the parkway showcase the transition from the para-autochthonous Blue Ridge anticlinorium of northern and central Virginia to the allochthonous eastern Blue Ridge in southern Virginia. From mile post (MP) 0 near Waynesboro, Virginia, to ~MP 124 at Roanoke, the parkway crosses the unconformable to faulted boundary between Mesoproterozoic basement in the core of the Blue Ridge anticlinorium and Neoproterozoic to Cambrian metasedimentary and metavolcanic cover rocks on the western limb of the structure. Mesoproterozoic basement rocks comprise two groups based on SHRIMP U-Pb zircon geochronology: Group I rocks (1.2-1.14 Ga) are strongly foliated orthogneisses, and Group II rocks (1.08-1.00 Ga) are granitoids that mostly lack obvious Mesoproterozoic deformational features.Neoproterozoic to Cambrian cover rocks on the west limb of the anticlinorium include the Swift Run and Catoctin Formations, and constituent formations of the Chilhowee Group. These rocks unconformably overlie basement, or abut basement along steep reverse faults. Rocks of the Chilhowee Group are juxtaposed against Cambrian rocks of the Valley and Ridge province along southeast- and northwest-dipping, high-angle reverse faults. South of the James River (MP 64), Chilhowee Group and basement rocks occupy the hanging wall of the nearly flat-lying Blue Ridge thrust fault and associated splays.South of the Red Valley high-strain zone (MP 144.5), the parkway crosses into the wholly allochthonous eastern Blue Ridge, comprising metasedimentary and meta-igneous rocks assigned to the Wills Ridge, Ashe, and Alligator

  4. Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) in HIV.

    PubMed

    Rockstroh, Jürgen Kurt

    2017-04-01

    Abnormal liver enzymes (LE) are common in patients infected with the human immunodeficiency virus (HIV) even in the absence of viral hepatitis or alcohol abuse. With availability of antiretroviral combination therapy, life expectancy has improved dramatically and as a consequence the spectrum of liver disease is changing. Increased reports on the development of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) in HIV coinfected patients raise questions around prevalence, clinical manifestations, and clinical outcome of these liver diseases in HIV coinfection. Moreover, the potential impact of combination antiretroviral therapy as well as direct HIV effects on the emergence of non-alcoholic fatty liver disease needs to be explored. This review summarizes the recent literature on NAFLD and NASH in HIV.

  5. Optimization, Monotonicity and the Determination of Nash Equilibria — An Algorithmic Analysis

    NASA Astrophysics Data System (ADS)

    Lozovanu, D.; Pickl, S. W.; Weber, G.-W.

    2004-08-01

    This paper is concerned with the optimization of a nonlinear time-discrete model exploiting the special structure of the underlying cost game and the property of inverse matrices. The costs are interlinked by a system of linear inequalities. It is shown that, if the players cooperate, i.e., minimize the sum of all the costs, they achieve a Nash equilibrium. In order to determine Nash equilibria, the simplex method can be applied with respect to the dual problem. An introduction into the TEM model and its relationship to an economic Joint Implementation program is given. The equivalence problem is presented. The construction of the emission cost game and the allocation problem is explained. The assumption of inverse monotony for the matrices leads to a new result in the area of such allocation problems. A generalization of such problems is presented.

  6. NASH resolution is associated with improvements in HDL and triglyceride levels but not improvement in LDL or non-HDL-C levels.

    PubMed

    Corey, K E; Vuppalanchi, R; Wilson, L A; Cummings, O W; Chalasani, N

    2015-02-01

    Nonalcoholic steatohepatitis (NASH) is associated with dyslipidemia and cardiovascular disease (CVD). To determine the relationship between resolution of NASH and dyslipidemia. Individuals in the Pioglitazone vs. Vitamin E vs. Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis (PIVENS) trial with paired liver biopsies and fasting lipid levels were included (N = 222). In the PIVENS trial individuals were randomised to pioglitazone 30 mg, vitamin E 800 IU or placebo for 96 weeks. Change in lipid levels at 96 weeks was compared between those with and without NASH resolution. Dyslipidemia at baseline was frequent, with low high-density lipoprotein (HDL) (<40 mg/dL in men or <50 mg/dL in women) in 63%, hypertriglyceridaemia (≥150 mg/dL) in 46%, hypercholesterolaemia (≥200 mg/dL) in 47% and triglycerides (TG)/HDL >5.0 in 25%. Low-density lipoprotein (LD) ≥160 mg/dL was found in 16% and elevated non-HDL cholesterol (non-HDL-C) (≥130 mg/dL) in 73%. HDL increased with NASH resolution but decreased in those without resolution (2.9 mg/dL vs. -2.5 mg/dL, P < 0.001). NASH resolution was associated with significant decreases in TG and TG/HDL ratio compared to those without resolution (TG: -21.1 vs. -2.3 mg/dL, P = 0.03 and TG/HDL: -0.7 vs. 0.1, P = 0.003). Non-HDL-C, LDL and cholesterol decreased over 96 weeks in both groups, but there was no significant difference between groups. Treatment group did not impact lipids. NASH resolution is associated with improvements in TG and HDL but not in other cardiovascular disease risk factors including LDL and non-HDL-C levels. Individuals with resolution of NASH may still be at increased risk of cardiovascular disease. ClinicalTrials.gov identifier: NCT00063622. © 2014 John Wiley & Sons Ltd.

  7. Pronounced Shear Velocity Asymmetry in the Mantle Across the Juan de Fuca Ridge and Curious Lack of Features at the Gorda Ridge

    NASA Astrophysics Data System (ADS)

    Bell, S. W.; Ruan, Y.; Forsyth, D. W.

    2015-12-01

    With new Rayleigh-wave tomography results, we have detected a clear and strong asymmetry in the shear velocity structure of the Juan de Fuca ridge. Concentrated in a relatively thin layer with a depth range of ~30-60km, there lies a region of very low shear velocity, with velocities ranging from ~3.8km/s to 4.0km/s. Such low velocities provide strong evidence for the presence of partial melt. This low-velocity region is highly asymmetric, extending much further west than east of the ridge. Especially at shallow depths of ~35 km, this low-velocity region is concentrated just west of the southern portion of the ridge. Peaking near the Axial Seamount, the youngest of the Cobb-Eickelberg Seamounts, it extends south to the region around the small Vance Seamounts just north of the junction with the Blanco Fracture Zone. The Juan de Fuca plate is relatively stationary in the hotspot reference frame, and the Juan de Fuca ridge migrates westward in the hotspot reference frame. Seamounts are overwhelmingly concentrated on the western flank of the ridge, and an asymmetric upwelling driven by migration in the hotspot reference frame has been proposed to explain the seamount asymmetry (i.e. Davis and Karsten, 1986). Our velocity asymmetry, which matches the seamount asymmetry, provides evidence for this asymmetric upwelling and its connection to migration in the absolute hotspot reference frame. In the shear velocity results, the Gorda ridge displays a remarkable lack of features, with no clearly identifiable expression in the subsurface velocity. There is evidence of a broad low-velocity feature beneath Gorda beginning at a depth of ~150 km, but no clear shallow features can be tied to the ridge. At the depths we can resolve (~25-250km), the anisotropy beneath and within the Juan de Fuca plate is small, indicating a deep source of the shear wave splitting results (Bodmer et al., in press), which indicate a fast axis aligned with the Juan de Fuca plate's absolute motion. Around

  8. Efficacy of docosahexaenoic acid-choline-vitamin E in paediatric NASH: a randomized controlled clinical trial.

    PubMed

    Zöhrer, Evelyn; Alisi, Anna; Jahnel, Jörg; Mosca, Antonella; Della Corte, Claudia; Crudele, Annalisa; Fauler, Günter; Nobili, Valerio

    2017-09-01

    Nonalcoholic steatohepatitis (NASH), a progressive form of nonalcoholic fatty liver disease, is one of the most common hepatic diseases in children. We conducted a randomized controlled clinical trial on children with biopsy-proven NASH based on a combinatorial nutritional approach compared with placebo. Participants were assigned to lifestyle modification plus placebo or lifestyle modification plus a mix containing docosahexaenoic acid, choline, and vitamin E (DHA-CHO-VE). Forty children and adolescents participated in the entire trial. The primary outcome was the improvement of liver hyperechogenicity. Secondary outcomes included alterations of alanine aminotransferase (ALT) and other metabolic parameters. Furthermore, changes of serum bile acids (BA) and plasma fibroblast growth factor 19 (FGF19) levels were evaluated as inverse biomarkers of disease severity. At the end of the study, we observed a significant decrease in severe steatosis in the treatment group (50% to 5%, p = 0.001). Furthermore, although the anthropometric and biochemical measurements in the placebo and DHA-CHO-VE groups were comparable at baseline, at the end of the study ALT and fasting glucose levels improved only in the treatment group. Finally, we found that BA levels were not influenced whereas FGF19 levels were significantly increased by DHA-CHO-VE. The results suggest that a combination of DHA, VE, and CHO could improve steatosis and reduce ALT and glucose levels in children with NASH. However, further studies are needed to assess the impact of a DHA and VE combination on repair of liver damage in paediatric NASH.

  9. Identification of hyper-extended crust east of Davie Ridge in the Mozambique Channel

    NASA Astrophysics Data System (ADS)

    Klimke, Jennifer; Franke, Dieter

    2015-04-01

    Davie Ridge is a ~1200 km wide, N-S trending bathymetrical high in the Mozambique Channel. Today, it is widely accepted that Davie Ridge is located along a fossil transform fault that was active during the Middle Jurassic and Early Cretaceous (~165-120 Ma). This transform fault results from the breakup of Gondwana, when Madagascar (together with India and Antarctica) drifted from its northerly position in the Gondwana Supercontinent (adjacent to the coasts of Tanzania, Somalia and Kenya) to its present position (e.g. Coffin and Rabinowitz, 1987; Rabinowitz et al., 1983; Segoufin and Patriat, 1980). The southward motion of Madagascar relative to Africa is constrained by the interpretation of magnetic anomalies in the Western Somali Basin, located north of Madagascar (e.g. Rabinowitz et al., 1983). According to Bird (2001), sheared margins share typical characteristics and a common evolution: 1. The transition from continental to oceanic crust is relatively abrupt (~ 50-80 km). 2. Along the continental side of the margin, complex rift basins form that display a wide range of faults. 3. Prominent marginal ridges form along the sheared margin that probably originate from the propagation of the oceanic spreading center along the plate boundary (Bird, 2001). In February and March 2014, a dense geophysical dataset (multichannel seismic, magnetics, gravimetry and bathymetry) with a total of 4300 profile km along the sheared margin was acquired with the R/V Sonne by the Federal Institute for Geosciences and Natural Resources (BGR). A special objective of the project, amongst others, is the characterization and interpretation of the continent-ocean transition seaward of Davie Ridge in the Mozambique Channel. Seismic profiles located east of Davie Ridge in the Western Somali Basin reveal a wide sequence of half-grabens bounded by listric normal faults. We tentatively suggest that this crust is of continental origin and results from rifting between Africa and Madagascar during

  10. TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival.

    PubMed

    Mridha, Auvro R; Haczeyni, Fahrettin; Yeh, Matthew M; Haigh, W Geoffrey; Ioannou, George N; Barn, Vanessa; Ajamieh, Hussam; Adams, Leon; Hamdorf, Jeffrey M; Teoh, Narci C; Farrell, Geoffrey C

    2017-08-15

    Background and aims : TLR9 deletion protects against steatohepatitis due to choline-amino acid depletion and high-fat diet. We measured TLR9 in human non-alcoholic steatohepatitis (NASH) livers, and tested whether TLR9 mediates inflammatory recruitment in three murine models of non-alcoholic fatty liver disease (NAFLD). Methods : We assayed TLR mRNA in liver biopsies from bariatric surgery patients. Wild-type ( Wt ), appetite-dysregulated Alms1 mutant (foz/foz), Tlr9 -/- , and Tlr9 -/- foz/foz C57BL6/J mice and bone marrow (BM) chimeras were fed 0.2% cholesterol, high-fat, high sucrose (atherogenic[Ath]) diet or chow, and NAFLD activity score (NAS)/NASH pathology, macrophage/neutrophil infiltration, cytokines/chemokines, and cell death markers measured in livers. Results : Hepatic TLR9 and TLR4 mRNA were increased in human NASH but not simple steatosis, and in Ath-fed foz/foz mice with metabolic syndrome-related NASH. Ath-fed Tlr9 -/- mice showed simple steatosis and less Th1 cytokines than Wt. Tlr9 -/- foz/foz mice were obese and diabetic, but necroinflammatory changes were less severe than Tlr9 +/+ .foz/foz mice. TLR9-expressing myeloid cells were critical for Th1 cytokine production in BM chimeras. BM macrophages from Tlr9 -/- mice showed M2 polarization, were resistant to M1 activation by necrotic hepatocytes/other pro-inflammatory triggers, and provoked less neutrophil chemotaxis than Wt Livers from Ath-fed Tlr9 -/- mice appeared to exhibit more markers of necroptosis [receptor interacting protein kinase (RIP)-1, RIP-3, and mixed lineage kinase domain-like protein (MLKL)] than Wt , and ∼25% showed portal foci of mononuclear cells unrelated to NASH pathology. Our novel clinical data and studies in overnutrition models, including those with diabetes and metabolic syndrome, clarify TLR9 as a pro-inflammatory trigger in NASH. This response is mediated via M1-macrophages and neutrophil chemotaxis. © 2017 The Author(s). Published by Portland Press Limited on

  11. Nash equilibrium strategy in the deregulated power industry and comparing its lost welfare with Iran wholesale electricity market

    NASA Astrophysics Data System (ADS)

    Mousavi, Seyed Hosein; Nazemi, Ali; Hafezalkotob, Ashkan

    2016-09-01

    With the increasing use of different types of auctions in market designing, modeling of participants' behaviors to evaluate the market structure is one of the main discussions in the studies related to the deregulated power industries. In this article, we apply an approach of the optimal bidding behavior to the Iran wholesale electricity market as a restructured electric power industry and model how the participants of the market bid in the spot electricity market. The problem is formulated analytically using the Nash equilibrium concept composed of large numbers of players having discrete and very large strategy spaces. Then, we compute and draw supply curve of the competitive market in which all generators' proposed prices are equal to their marginal costs and supply curve of the real market in which the pricing mechanism is pay-as-bid. We finally calculate the lost welfare or inefficiency of the Nash equilibrium and the real market by comparing their supply curves with the competitive curve. We examine 3 cases on November 24 (2 cases) and July 24 (1 case), 2012. It is observed that in the Nash equilibrium on November 24 and demand of 23,487 MW, there are 212 allowed plants for the first case (plants are allowed to choose any quantity of generation except one of them that should be equal to maximum Power) and the economic efficiency or social welfare of Nash equilibrium is 2.77 times as much as the real market. In addition, there are 184 allowed plants for the second case (plants should offer their maximum power with different prices) and the efficiency or social welfare of Nash equilibrium is 3.6 times as much as the real market. On July 24 and demand of 42,421 MW, all 370 plants should generate maximum energy due to the high electricity demand that the economic efficiency or social welfare of the Nash equilibrium is about 2 times as much as the real market.

  12. Bifurcations and catastrophes in a nonlinear dynamical model of the western Pacific subtropical high ridge line index and its evolution mechanism

    NASA Astrophysics Data System (ADS)

    Hong, Mei; Zhang, Ren; Li, Ming; Wang, Shuo; Zeng, Wenhua; Wang, Zhengxin

    2017-07-01

    Despite much previous effort, the establishment of an accurate model of the western Pacific subtropical high (WPSH) and analysis of its chaotic behavior has proved to be difficult. Based on a phase-space technique, a nonlinear dynamical model of the WPSH ridge line and summer monsoon factors is constructed here from 50 years of data. Using a genetic algorithm, model inversion and parameter optimization are performed. The Lyapunov spectrum, phase portraits, time history, and Poincaré surface of section of the model are analyzed and an initial-value sensitivity test is performed, showing that the model and data have similar phase portraits and that the model is robust. Based on equilibrium stability criteria, four types of equilibria of the model are analyzed. Bifurcations and catastrophes of the equilibria are studied and related to the physical mechanism and actual weather phenomena. The results show that the onset and enhancement of the Somali low-level jet and the latent heat flux of the Indian monsoon are among the most important reasons for the appearance and maintenance of the double-ridge phenomenon. Violent breakout and enhancement of the Mascarene cold high will cause the WPSH to jump northward, resulting in the "empty plum" phenomenon. In the context of bifurcation and catastrophe in the dynamical system, the influence of the factors considered here on the WPSH has theoretical and practical significance. This work also opens the way to new lines of research on the interaction between the WPSH and the summer monsoon system.

  13. Geometry of Cournot-Nash Equilibrium with Application to Commons and Anticommons

    ERIC Educational Resources Information Center

    D'Agata, Antonio

    2010-01-01

    The author develops a simple geometric analysis of Cournot-Nash equilibrium in the price-quantity space by exploiting the economic content of the first-order condition. The approach makes it clear that strategic interdependency in oligopoly originates from externalities among producers. This explains why cartels are unstable and casts oligopoly…

  14. Challenges and Management of Liver Cirrhosis: Practical Issues in the Therapy of Patients with Cirrhosis due to NAFLD and NASH.

    PubMed

    Traussnigg, Stefan; Kienbacher, Christian; Halilbasic, Emina; Rechling, Christian; Kazemi-Shirazi, Lili; Hofer, Harald; Munda, Petra; Trauner, Michael

    2015-01-01

    Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and comprises a liver disease spectrum ranging from steatosis to nonalcoholic steatohepatitis (NASH) with risk of progression to liver cirrhosis and hepatocellular carcinoma (HCC). Associated metabolic conditions and comorbidities such as obesity, diabetes and cardiovascular diseases are common and require concerted management. Adiponutrin (PNPLA3) variants may help to identify NAFLD patients at higher risk for liver disease progression towards advanced fibrosis and HCC. The therapeutic options in NAFLD/NASH include lifestyle modification, pharmacological treatment, bariatric surgery for patients with morbid obesity and treatment of complications of liver cirrhosis and HCC, including liver transplantation. Insulin sensitizers and antioxidative treatment strategies with vitamin E are among the best-established pharmacological approaches, but both drugs have long-term safety issues and there is limited evidence in cirrhotic patients. Treatment of concomitant/underlying metabolic conditions with statins or metformin may also have beneficial effects on portal hypertension, complications of liver cirrhosis and HCC prevention. The bile acid receptor FXR may be a promising novel therapeutic target for the treatment of NAFLD/NASH, fibrosis and portal hypertension, but the prognostic implications of associated changes in low- and high-density lipoprotein cholesterol require further studies. Morbidly obese NASH patients can benefit from bariatric surgery which may reduce liver fibrosis but carries a risk of decompensation in patients with advanced liver cirrhosis. When carefully selected, patients with NASH cirrhosis undergoing liver transplantation have a good outcome. This review summarizes recent progress in the management of patients with liver cirrhosis due to NASH. © 2015 S. Karger AG, Basel.

  15. Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH

    PubMed Central

    Ioannou, George N.; Van Rooyen, Derrick M.; Savard, Christopher; Haigh, W. Geoffrey; Yeh, Matthew M.; Teoh, Narci C.; Farrell, Geoffrey C.

    2015-01-01

    Cholesterol crystals form within hepatocyte lipid droplets in human and experimental nonalcoholic steatohepatitis (NASH) and are the focus of crown-like structures (CLSs) of activated Kupffer cells (KCs). Obese, diabetic Alms1 mutant (foz/foz) mice were a fed high-fat (23%) diet containing 0.2% cholesterol for 16 weeks and then assigned to four intervention groups for 8 weeks: a) vehicle control, b) ezetimibe (5 mg/kg/day), c) atorvastatin (20 mg/kg/day), or d) ezetimibe and atorvastatin. Livers of vehicle-treated mice developed fibrosing NASH with abundant cholesterol crystallization within lipid droplets calculated to extend over 3.3% (SD, 2.2%) of liver surface area. Hepatocyte lipid droplets with prominent cholesterol crystallization were surrounded by TNFα-positive (activated) KCs forming CLSs (≥3 per high-power field). KCs that formed CLSs stained positive for NLRP3, implicating activation of the NLRP3 inflammasome in response to cholesterol crystals. In contrast, foz/foz mice treated with ezetimibe and atorvastatin showed near-complete resolution of cholesterol crystals [0.01% (SD, 0.02%) of surface area] and CLSs (0 per high-power field), with amelioration of fibrotic NASH. Ezetimibe or atorvastatin alone had intermediate effects on cholesterol crystallization, CLSs, and NASH. These findings are consistent with a causative link between exposure of hepatocytes and KCs to cholesterol crystals and with the development of NASH possibly mediated by NLRP3 activation. PMID:25520429

  16. Clinical Model for NASH and Advanced Fibrosis in Adult Patients With Diabetes and NAFLD: Guidelines for Referral in NAFLD

    PubMed Central

    Bazick, Jessica; Donithan, Michele; Neuschwander-Tetri, Brent A.; Kleiner, David; Brunt, Elizabeth M.; Wilson, Laura; Doo, Ed; Lavine, Joel; Tonascia, James

    2015-01-01

    OBJECTIVE Approximately 18 million people in the U.S. have coexisting type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). It is not known who among these patients has nonalcoholic steatohepatitis (NASH) with advanced fibrosis. Therefore, we aimed to determine factors that are associated with both NASH and advanced fibrosis in patients with diabetes and NAFLD in order to identify who should be prioritized for referral to a hepatologist for further diagnostic evaluation and treatment. RESEARCH DESIGN AND METHODS This study was derived from the NASH Clinical Research Network studies and included 1,249 patients with biopsy-proven NAFLD (including a model development cohort of 346 patients and an independent validation cohort of 100 patients with type 2 diabetes as defined by the American Diabetes Association criteria). Outcome measures were presence of NASH or advanced fibrosis (stage 3 or 4) using cross-validated, by jackknife method, multivariable-adjusted area under the receiver operating characteristic curve (AUROC) and 95% CI. RESULTS The mean ± SD age and BMI of patients with diabetes and NAFLD was 52.5 ± 10.3 years and 35.8 ± 6.8 kg/m2, respectively. The prevalence of NASH and advanced fibrosis was 69.2% and 41.0%, respectively. The model for NASH included white race, BMI, waist, alanine aminotransferase (ALT), Aspartate aminotransferase (AST), albumin, HbA1c, HOMA of insulin resistance, and ferritin with an AUROC of 0.80 (95% CI 0.75–0.84, P = 0.007). The specificity, sensitivity, negative predictive values (NPVs), and positive predictive values (PPVs) were 90.0%, 56.8%, 47.7%, and 93.2%, respectively, and the model correctly classified 67% of patients as having NASH. The model for predicting advanced fibrosis included age, Hispanic ethnicity, BMI, waist-to-hip ratio, hypertension, ALT-to-AST ratio, alkaline phosphatase, isolated abnormal alkaline phosphatase, bilirubin (total and direct), globulin, albumin, serum insulin, hematocrit

  17. Characterizing the Nash equilibria of three-player Bayesian quantum games

    NASA Astrophysics Data System (ADS)

    Solmeyer, Neal; Balu, Radhakrishnan

    2017-05-01

    Quantum games with incomplete information can be studied within a Bayesian framework. We analyze games quantized within the EWL framework [Eisert, Wilkens, and Lewenstein, Phys Rev. Lett. 83, 3077 (1999)]. We solve for the Nash equilibria of a variety of two-player quantum games and compare the results to the solutions of the corresponding classical games. We then analyze Bayesian games where there is uncertainty about the player types in two-player conflicting interest games. The solutions to the Bayesian games are found to have a phase diagram-like structure where different equilibria exist in different parameter regions, depending both on the amount of uncertainty and the degree of entanglement. We find that in games where a Pareto-optimal solution is not a Nash equilibrium, it is possible for the quantized game to have an advantage over the classical version. In addition, we analyze the behavior of the solutions as the strategy choices approach an unrestricted operation. We find that some games have a continuum of solutions, bounded by the solutions of a simpler restricted game. A deeper understanding of Bayesian quantum game theory could lead to novel quantum applications in a multi-agent setting.

  18. Role of white adipose lipolysis in the development of NASH induced by methionine-and choline-deficient diet

    PubMed Central

    Tanaka, Naoki; Takahashi, Shogo; Fang, Zhong-Ze; Matsubara, Tsutomu; Krausz, Kristopher W.; Qu, Aijuan; Gonzalez, Frank J.

    2014-01-01

    Methionine- and choline-deficient diet (MCD) is a model for nonalcoholic steatohepatitis (NASH) in rodents. However, the mechanism of NASH development by dietary methionine/choline deficiency remains undetermined. To elucidate the early metabolic changes associated with MCD-NASH, serum metabolomic analysis was performed using mice treated with MCD and control diet for three days and one week, revealing significant increases in oleic and linoleic acids after MCD treatment. These increases were correlated with reduced body weight and white adipose tissue (WAT) mass, increased phosphorylation of hormone-sensitive lipase, and up-regulation of genes encoding carboxylesterase 3 and β2-adrenergic receptor in WAT, indicating accelerated lipolysis in adipocytes. The changes in serum fatty acids and WAT by MCD treatment were reversed by methionine supplementation, and similar alterations were detected in mice fed a methionine-deficient diet (MD), thus demonstrating that dietary methionine deficiency enhances lipolysis in WAT. MD treatment decreased glucose and increased fibroblast growth factor 21 in serum, thus exhibiting a similar metabolic phenotype as the fasting response. Comparison between MCD and choline-deficient diet (CD) treatments suggested that the addition of MD-induced metabolic alterations, such as WAT lipolysis, to CD-induced hepatic steatosis promotes liver injury. Collectively, these results demonstrate an important role for dietary methionine deficiency and WAT lipolysis in the development of MCD-NASH. PMID:25178843

  19. Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

    PubMed Central

    Machado, Mariana Verdelho; Michelotti, Gregory Alexander; Xie, Guanhua; de Almeida, Thiago Pereira; Boursier, Jerome; Bohnic, Brittany; Guy, Cynthia D.; Diehl, Anna Mae

    2015-01-01

    Background and aims Non-alcoholic steatohepatitis (NASH), the potentially progressive form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time. Although there are several animal models of NASH, consensus regarding the optimal model is lacking. We aimed to compare features of NASH in the two most widely-used mouse models: methionine-choline deficient (MCD) diet and Western diet. Methods Mice were fed standard chow, MCD diet for 8 weeks, or Western diet (45% energy from fat, predominantly saturated fat, with 0.2% cholesterol, plus drinking water supplemented with fructose and glucose) for 16 weeks. Liver pathology and metabolic profile were compared. Results The metabolic profile associated with human NASH was better mimicked by Western diet. Although hepatic steatosis (i.e., triglyceride accumulation) was also more severe, liver non-esterified fatty acid content was lower than in the MCD diet group. NASH was also less severe and less reproducible in the Western diet model, as evidenced by less liver cell death/apoptosis, inflammation, ductular reaction, and fibrosis. Various mechanisms implicated in human NASH pathogenesis/progression were also less robust in the Western diet model, including oxidative stress, ER stress, autophagy deregulation, and hedgehog pathway activation. Conclusion Feeding mice a Western diet models metabolic perturbations that are common in humans with mild NASH, whereas administration of a MCD diet better models the pathobiological mechanisms that cause human NAFLD to progress to advanced NASH. PMID:26017539

  20. Submarine sand ridges and sand waves in the eastern part of the China Sea

    NASA Astrophysics Data System (ADS)

    Wu, Ziyin; Li, Shoujun; Shang, Jihong; Zhou, Jieqiong; Zhao, Dineng; Liang, Yuyang

    2016-04-01

    Integrated with multi-beam and single-beam echo sounding data, as well as historical bathymetric data, submarine bathymetric maps of the eastern part of the China Sea, including the Bohai Sea, Huanghai Sea, and East China Sea, are constructed to systematically study submarine sand ridges and sand waves in the eastern part of the China Sea, combined with high-resolution seismic, sub-bottom profile and borehole data. Submarine sand ridges are extraordinarily developed in the eastern part of the China Sea, and 7 sand ridge areas can be divided from north to south, that is, the Laotieshan Channel sand ridge area in the Bohai Sea, the Korea Bay sand ridge area in the southern Huanghai Sea, the sand ridge area in the eastern Huanghai islands and the Huanghai Troughs, the Jianggang sand ridge area in the western Huanghai Sea, the sand ridge area in the East China Sea shelf, and the sand ridge and sand wave area in the Taiwan Strait and Taiwan Banks. The distribution area of the sand ridges and sand waves covers more than 450,000 km2, wherein ~10,000 km2 in the Bohai Bay, ~200,000 km2 in the Huanghai Sea, ~200,000 km2 in the East China Sea shelf, and ~40,000 km2 in the Taiwan Strait and Taiwan Banks, respectively. The great mass of sand ridges are distributed within water depth of 5-160 m, with a total length of over 160 km and a main width of 5-10 km. The inner structure of the sand ridges presents features of high-angle inclined beddings, with main lithology of sands, sand-mud alternations partly visible, and a small number of mud cores. Dating results indicate that the sand ridges in the eastern part of the China Sea are mainly developed in the Holocene. Sea-level variation dominates the sand ridge evolution in the eastern part of the China Sea since the LGM, and the sand ridges developed in the area of < 60m water depth are appeared in bad activity, meanwhile sand ridges with good activity are still developed in large scale.

  1. General view looking eastnortheast at western end of array ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General view looking east-northeast at western end of array - Over-the-Horizon Backscatter Radar Network, Columbia Falls Radar Site Receive Sector Three Antenna Array, At the end of Shadagee Ridge Road, Columbia Falls, Washington County, ME

  2. Crustal Thickness on the South East Indian Ridge from OBH data

    NASA Astrophysics Data System (ADS)

    Tolstoy, M.; Cochran, J. R.; Carbotte, S. M.; Floyd, J. S.

    2002-12-01

    Seismic reflection and refraction data were collected on the intermediate-rate spreading South East Indian Ridge during December 2001 and January 2002 aboard the RV Ewing. A total of six lines of Ocean Bottom Hydrophone (OBH) refraction data were collected along four segments with contrasting ridge axis morphology. All lines were shot ridge parallel, with four lines on-axis, and two lines approximately 20 km off-axis. Each line used four OBHs and the line lengths varied between 102 km and 124 km, depending on the length of each ridge segment. For the two western most segments, an axial magma chamber is observed with crustal arrivals disappearing or being significantly delayed in the 15-20 km range. This indicates a magma chamber deeper than those observed on the faster spreading East Pacific Rise. Off-axis in this area clear crustal arrivals are seen out to 40-50 km. This indicates relatively thick crust in this most inflated of the sections studied, consistent with a higher magma supply. The two eastern most segments have on-axis lines only, and both of these indicate relatively thin crust. This is consistent with the more magma starved character of the bathymetry in these areas. Data will be presented, along with preliminary crustal velocity and thickness models.

  3. A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition.

    PubMed

    Krishnan, Anuradha; Abdullah, Tasduq Sheikh; Mounajjed, Taofic; Hartono, Stella; McConico, Andrea; White, Thomas; LeBrasseur, Nathan; Lanza, Ian; Nair, Sreekumaran; Gores, Gregory; Charlton, Michael

    2017-06-01

    The sequence of events that lead to inflammation and fibrosing nonalcoholic steatohepatitis (NASH) is incompletely understood. Hence, we investigated the chronology of whole body, tissue, and cellular events that occur during the evolution of diet-induced NASH. Male C57Bl/6 mice were assigned to a fast-food (FF; high calorie, high cholesterol, high fructose) or standard-chow (SC) diet over a period of 36 wk. Liver histology, body composition, mitochondrial respiration, metabolic rate, gene expression, and hepatic lipid content were analyzed. Insulin resistance [homeostasis model assessment-insulin resistance (HOMA-IR)] increased 10-fold after 4 wk. Fibrosing NASH was fully established by 16 wk. Total hepatic lipids increased by 4 wk and remained two- to threefold increased throughout. Hepatic triglycerides declined from sixfold increase at 8 wk to threefold increase by 36 wk. In contrast, hepatic cholesterol levels steadily increased from baseline at 8 wk to twofold by 36 wk. The hepatic immune cell population altered over time with macrophages persisting beyond 16 wk. Mitochondrial oxygen flux rates of FF mice diet were uniformly lower with all the tested substrates (13-276 pmol·s -1 ·ml -1 per unit citrate synthase) than SC mice (17-394 pmol·s -1 ·ml -1 per unit citrate synthase) and was accompanied by decreased mitochondrial:nuclear gene copy number ratios after 4 wk. Metabolic rate was lower in FF mice. Mitochondrial glutathione was significantly decreased at 24 wk in FF mice. Expression of dismutases and catalase was also decreased in FF mice. The evolution of NASH in the FF diet-induced model is multiphasic, particularly in terms of hepatic lipid composition. Insulin resistance precedes hepatic inflammation and fibrosis. Mitochondrial dysfunction and depletion occur after the histological features of NASH are apparent. Collectively, these observations provide a unique overview of the sequence of changes that coevolve with the histological evolution of

  4. Clinical Model for NASH and Advanced Fibrosis in Adult Patients With Diabetes and NAFLD: Guidelines for Referral in NAFLD.

    PubMed

    Bazick, Jessica; Donithan, Michele; Neuschwander-Tetri, Brent A; Kleiner, David; Brunt, Elizabeth M; Wilson, Laura; Doo, Ed; Lavine, Joel; Tonascia, James; Loomba, Rohit

    2015-07-01

    Approximately 18 million people in the U.S. have coexisting type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). It is not known who among these patients has nonalcoholic steatohepatitis (NASH) with advanced fibrosis. Therefore, we aimed to determine factors that are associated with both NASH and advanced fibrosis in patients with diabetes and NAFLD in order to identify who should be prioritized for referral to a hepatologist for further diagnostic evaluation and treatment. This study was derived from the NASH Clinical Research Network studies and included 1,249 patients with biopsy-proven NAFLD (including a model development cohort of 346 patients and an independent validation cohort of 100 patients with type 2 diabetes as defined by the American Diabetes Association criteria). Outcome measures were presence of NASH or advanced fibrosis (stage 3 or 4) using cross-validated, by jackknife method, multivariable-adjusted area under the receiver operating characteristic curve (AUROC) and 95% CI. The mean ± SD age and BMI of patients with diabetes and NAFLD was 52.5 ± 10.3 years and 35.8 ± 6.8 kg/m(2), respectively. The prevalence of NASH and advanced fibrosis was 69.2% and 41.0%, respectively. The model for NASH included white race, BMI, waist, alanine aminotransferase (ALT), Aspartate aminotransferase (AST), albumin, HbA1c, HOMA of insulin resistance, and ferritin with an AUROC of 0.80 (95% CI 0.75-0.84, P = 0.007). The specificity, sensitivity, negative predictive values (NPVs), and positive predictive values (PPVs) were 90.0%, 56.8%, 47.7%, and 93.2%, respectively, and the model correctly classified 67% of patients as having NASH. The model for predicting advanced fibrosis included age, Hispanic ethnicity, BMI, waist-to-hip ratio, hypertension, ALT-to-AST ratio, alkaline phosphatase, isolated abnormal alkaline phosphatase, bilirubin (total and direct), globulin, albumin, serum insulin, hematocrit, international normalized ratio, and platelet count with

  5. Maturation of large scale mass-wasting along the Hawaiian Ridge

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Torresan, M.E.; Clague, D.A.; Moore, J.G.

    1990-06-01

    Extensive GLORIA side-scan sonar mapping of the Hawaiian Ridge from Hawaii to St. Rogatien Bank shows that massive slumps and blocky debris avalanches are the major degradational processes that affect the island and ridge areas. About 30 failures have been imaged in the region surveyed; they range in area from 250 to > 6,000 km{sup 2} and in volume from 500 to > 5,000 km{sup 3}. Four are rotational slumps, and the rest are blocky debris avalanches. Such deposits cover 125,000 km{sup 2} of the Hawaiian Ridge and adjacent seafloor. The slumps are wide (up to 110 km), short (30-35more » km), thick (about 10 km), and slow moving. They are broken into comparatively few major rotational blocks that have not moved far and are characterized by steep toes and transverse ridges. Back rotation of the blocks has elevated their seaward edges, producing transverse ridges and perched basins filled with 5 to > 35 m of sediment. Compared to the slumps, the debris avalanches are lobate, long (up to 230 km), thin (0.5-2 km), and fast-moving. These deposits cross the Hawaiian Trough and run upslope onto the Hawaiian Arch (up to 550 m in elevation over a distance of 140 km). These failures commonly have amphitheaters and subaerial canyons at their heads. Their distal ends are hummocky, and blocky debris litters the seafloor adjacent to the ridge. As one proceeds west from Hawaii to St. Rogatien Bank, the GLORIA sonographs and seismic reflection profiles show a progression from youthful to mature failures and from active to about 12 Ma volcanoes. The Alika and Hilina slide complexes are examples of youthful failures on active volcanoes. Slumping in the Hilina slide is ongoing (7.2 magnitude earthquake in 1975). Little to no sediment covers the blocks and hummocky terrane of the Alika (about 100 ka), whereas the older deposits along the western part of the ridge are covered by up to 30 m of transparent sediment.« less

  6. Probable Causes of the Abnormal Ridge Accompanying the 2013-2014 California Drought: ENSO Precursor and Anthropogenic Warming Footprint

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, S-Y; Hipps, Lawrence; Gillies, Robert R.

    2014-05-16

    The 2013-14 California drought was accompanied by an anomalous high-amplitude ridge system. The anomalous ridge was investigated using reanalysis data and the Community Earth System Model (CESM). It was found that the ridge emerged from continual sources of Rossby wave energy in the western North Pacific starting in late summer, and subsequently intensified into winter. The ridge generated a surge of wave energy downwind and deepened further the trough over the northeast U.S., forming a dipole. The dipole and associated circulation pattern is not linked directly with either ENSO or Pacific Decadal Oscillation; instead it is correlated with a typemore » of ENSO precursor. The connection between the dipole and ENSO precursor has become stronger since the 1970s, and this is attributed to increased GHG loading as simulated by the CESM. Therefore, there is a traceable anthropogenic warming footprint in the enormous intensity of the anomalous ridge during winter 2013-14, the associated drought and its intensity.« less

  7. Probable causes of the abnormal ridge accompanying the 2013-2014 California drought: ENSO precursor and anthropogenic warming footprint

    NASA Astrophysics Data System (ADS)

    Wang, S.-Y.; Hipps, Lawrence; Gillies, Robert R.; Yoon, Jin-Ho

    2014-05-01

    The 2013-2014 California drought was initiated by an anomalous high-amplitude ridge system. The anomalous ridge was investigated using reanalysis data and the Community Earth System Model (CESM). It was found that the ridge emerged from continual sources of Rossby wave energy in the western North Pacific starting in late summer and subsequently intensified into winter. The ridge generated a surge of wave energy downwind and deepened further the trough over the northeast U.S., forming a dipole. The dipole and associated circulation pattern is not linked directly with either El Niño-Southern Oscillation (ENSO) or Pacific Decadal Oscillation; instead, it is correlated with a type of ENSO precursor. The connection between the dipole and ENSO precursor has become stronger since the 1970s, and this is attributed to increased greenhouse gas loading as simulated by the CESM. Therefore, there is a traceable anthropogenic warming footprint in the enormous intensity of the anomalous ridge during winter 2013-2014 and the associated drought.

  8. A long-acting FGF21 alleviates hepatic steatosis and inflammation in NASH mice partly through an FGF21- adiponectin- IL17A axis.

    PubMed

    Bao, Lichen; Yin, Jun; Gao, Wen; Wang, Qun; Yao, Wenbing; Gao, Xiangdong

    2018-06-02

    NASH is the most severe form of NAFLD and is a serious public health problem around the world. There are currently no approved treatments for NASH. FGF21 has recently emerged as a promising drug candidate for metabolic diseases. However, the challenges in developing FGF21 as a novel medicine include its short plasma half-life and poor drug-like properties. Here, we explored the therapeutic effects of PsTag600-FGF21, an engineered long-acting FGF21 fusion protein, in NASH mice and revealed some of the mechanisms responsible for this activity. A long-acting FGF21 was prepared by genetic fusion with a 600 residues polypeptide (PsTag600). We conducted our studies using a choline-deficient high-fat diet (CD-HFD) induced NASH mouse model. In NASH mice, the effects on body weight, insulin sensitivity, inflammation and levels of hormones and metabolites were studied first. We further investigated whether PsTag600-FGF21 attenuated inflammation through the Th17-IL17A axis and the associated mechanisms. PsTag600-FGF21 dose-dependently reduced body weight, blood glucose, insulin and lipid levels and reversed hepatic steatosis. PsTag600-FGF21 enhanced fatty acid activation and mitochondrial β-oxidation in the liver. The profound reduction in hepatic inflammation in NASH mice was associated with PsTag600-FGF21 inhibition of IL17A expression in Th17 cells. Furthermore, PsTag600-FGF21 depended on adiponectin to exert its suppression effects on Th17 cell differentiation and IL17A expression. Our data begin to uncover the indirect mechanism by which PsTag600-FGF21 suppresses hepatic inflammation and further suggest that PsTag600-FGF21 could be an effective approach in NASH treatment. This article is protected by copyright. All rights reserved.

  9. Effects of Watershed Land Use and Geomorphology on Stream Baseflows in the Southern Blue Ridge Mountains

    EPA Science Inventory

    The current understanding of watershed hydrology does not provide insight into prediction of low-flow response to land-use change in developing regions like the Blue Ridge of north Georgia and western North Carolina. To address this problem, three separate but complementary stud...

  10. A 1.5 Ma record of plume-ridge interaction at the Western Galápagos Spreading Center (91°40‧-92°00‧W)

    NASA Astrophysics Data System (ADS)

    Herbrich, Antje; Hauff, Folkmar; Hoernle, Kaj; Werner, Reinhard; Garbe-Schönberg, Dieter; White, Scott

    2016-07-01

    Shallow (elevated) portions of mid-ocean ridges with enriched geochemical compositions near hotspots document the interaction of hot, geochemically-enriched plume mantle with shallow depleted upper mantle. Whereas the spatial variations in geochemical composition of ocean crust along the ridge axis in areas where plume-ridge interaction is taking place have been studied globally, only restricted information exists concerning temporal variations in geochemistry of ocean crust formed through plume-ridge interaction. Here we present a detailed geochemical study of 0-1.5 Ma ocean crust sampled from the Western Galápagos Spreading Center (WGSC) axis to 50 km north of the axis, an area that is presently experiencing a high influx of mantle material from the Galápagos hotspot. The tholeiitic to basaltic andesitic fresh glass and few bulk rock samples have incompatible element abundances and Sr-Nd-Pb isotopic compositions intermediate between depleted normal mid-ocean-ridge basalt (N-MORB) from >95.5°W along the WGSC and enriched lavas from the Galápagos Archipelago, displaying enriched (E-)MORB type compositions. Only limited and no systematic geochemical variations are observed with distance from the ridge axis for <1.0 Ma old WGSC crust, whereas 1.0-1.5 Ma old crust trends to more enriched isotopic compositions in 87Sr/86Sr, 143Nd/144Nd, 207Pb/204Pb and 208Pb/204Pb isotope ratios. On isotope correlation diagrams, the data set displays correlations between depleted MORB and two enriched components. Neither the geographically referenced geochemical domains of the Galápagos Archipelago nor the end members used for principal component analysis can successfully describe the observed mixing relations. Notably an off-axis volcanic cone at site DR63 has the appropriate composition to serve as the enriched component for the younger WGSC and could represent a portion of the northern part of the Galápagos plume not sampled south of the WGSC. Similar compositions to samples

  11. Remedial Investigation Work Plan for Chestnut Ridge Operable Unit 1 (Chestnut Ridge Security Pits) at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-03-01

    This document outlines the activities necessary to conduct a Remedial Investigation (RI) of the Chestnut Ridge Security Pits (CRSP) at the Oak Ridge Y-12 Plant. The CRSP, also designated Chestnut Ridge Operable Unit (OU) 1, is one of four OUs along Chestnut Ridge on the Oak Ridge Reservation (ORR). The purpose of the RI is to collect data to (1) evaluate the nature and extent of known and suspected contaminants, (2) support an Ecological Risk Assessment (ERA) and a Human Health Risk Assessment (HHRA), (3) support the feasibility study in the development and analysis of remedial alternatives, and (4) ultimately,more » develop a Record of Decision (ROD) for the site. This chapter summarizes the regulatory background of environmental investigation on the ORR and the approach currently being followed and provides an overview of the RI to be conducted at the CRSP. Subsequent chapters provide details on site history, sampling activities, procedures and methods, quality assurance (QA), health and safety, and waste management related to the RI.« less

  12. GPS Velocity Field at the Western Tip of the Aden Ridge ; Implications for Rifting and the Arabia-Somalia-Nubia Triple Junction Dynamics

    NASA Astrophysics Data System (ADS)

    Doubre, C.; Socquet, A.; Masson, F.; Cressot, C.; Mohamed, K.; Vigny, C.; Ruegg, J.

    2010-12-01

    Due to the presence of magma and a complex thermal structure, the dynamics of divergent plate boundaries are complicated, with microseismicity (ML<4) contributing very little to the total moment release. For the last 35 years several geodetic campaigns have been conducted at the western tip of the Aden Ridge propagating on land into Afar (Republic of Djibouti). The first segment above water, the Asal Rift, experienced a seismo-volcanic event in 1978, which was the first rifting episode, along with the 1978-1985 Icelandic Krafla event, to be monitored by terrestrial geodetic measurements. These measurements revealed the opening of two 1-2 m-wide dykes in the rift inner floor. Since then, terrestrial and spatial geodetic monitoring shows that the rift kept opening, during the post-rifting period, at a rate largely exceeding the plates’ motions. This significant opening rate is decreasing with time to tend, three decades after the rifting event, to the far-field opening rate. We present here the results of the GPS measurements of a 45 site network covering the Tadjoura-Asal Rift System, previously made every two years from 1995 to 2003, and repeated in 2010. The calculated 1999-2010 horizontal velocity field is very homogeneous with a quasi-constant N045° direction with respect to Somalia and a regular increase from the southern to the northern margin of the Asal Rift clearly controlled by a few normal faults, and reaching a maximum of 12.5 mm/yr. A non-negligible part of the Arabia-Somalia divergent movement (1 to 2 mm/yr) is observed south of this rift, which sheds light on the role of the active normal faults bounding the asymmetrical Gaggadé Basin and therefore brings important constraints on the location of the Red Sea Ridge-Aden Ridge-East African Rift triple junction. Since the last 2003 campaign, the lack of micro-seismicity within the Asal Rift seems to be associated with a ˜2 mm/yr decrease of the opening rate deduced from the GPS time series analysis

  13. Nash Equilibria in Theory of Reasoned Action

    NASA Astrophysics Data System (ADS)

    Almeida, Leando; Cruz, José; Ferreira, Helena; Pinto, Alberto Adrego

    2009-08-01

    Game theory and Decision Theory have been applied to many different areas such as Physics, Economics, Biology, etc. In its application to Psychology, we introduce, in the literature, a Game Theoretical Model of Planned Behavior or Reasoned Action by establishing an analogy between two specific theories. In this study we take in account that individual decision-making is an outcome of a process where group decisions can determine individual probabilistic behavior. Using Game Theory concepts, we describe how intentions can be transformed in behavior and according to the Nash Equilibrium, this process will correspond to the best individual decision/response taking in account the collective response. This analysis can be extended to several examples based in the Game Theoretical Model of Planned Behavior or Reasoned Action.

  14. Nash Equilibrium of Social-Learning Agents in a Restless Multiarmed Bandit Game.

    PubMed

    Nakayama, Kazuaki; Hisakado, Masato; Mori, Shintaro

    2017-05-16

    We study a simple model for social-learning agents in a restless multiarmed bandit (rMAB). The bandit has one good arm that changes to a bad one with a certain probability. Each agent stochastically selects one of the two methods, random search (individual learning) or copying information from other agents (social learning), using which he/she seeks the good arm. Fitness of an agent is the probability to know the good arm in the steady state of the agent system. In this model, we explicitly construct the unique Nash equilibrium state and show that the corresponding strategy for each agent is an evolutionarily stable strategy (ESS) in the sense of Thomas. It is shown that the fitness of an agent with ESS is superior to that of an asocial learner when the success probability of social learning is greater than a threshold determined from the probability of success of individual learning, the probability of change of state of the rMAB, and the number of agents. The ESS Nash equilibrium is a solution to Rogers' paradox.

  15. Geology of the Mount Rogers area, revisited: Evidence of Neoproterozoic continental rifting, glaciation, and the opening and closing of the Iapetus ocean, Blue Ridge, VA–NC–TN

    USGS Publications Warehouse

    Merschat, Arthur J.; Southworth, C. Scott; Holm-Denoma, Christopher S.; McAleer, Ryan J.; Merschat, Arthur J.

    2016-01-01

    -strain zone, occur in the Blue Ridge thrust sheet. Fabrics across the Fries and Gossan Lead faults have similar orientations and NW–directed contractional deformation. 40Ar/39Ar hornblende, muscovite, and K-feldspar ages indicate the western and eastern Blue Ridge had different thermal histories. The eastern Blue Ridge (Gossan Lead thrust sheet) experienced a 360–340 Ma amphibolite facies event prior to juxtaposition with the western Blue Ridge. 40Ar/39Ar muscovite ages in western Blue Ridge rocks document greenschist facies metamorphism and deformation and emplacement of the Blue Ridge thrust sheet at ~340 Ma; the Catface and Fries faults are tentatively interpreted to be contemporaneous. After initial emplacement of the Blue Ridge thrust sheet at ~340 Ma, shortening was accommodated by westward translation along the basal decollement, which carried the Blue Ridge thrust sheet to its final position.

  16. Holocene erosion, sedimentation, and stratigraphy at Raven Fork, Southern Blue Ridge Mountains, USA

    Treesearch

    David S. Leigh; Paul A. Webb

    2006-01-01

    Holocene colluvial and alluvial stratigraphy and a radiocarbon chronology are presented for the valley of the lower three kilometers of Raven Fork, a mountain stream draining 194 km2 of high relief (1.3 km) terrain of the Southern Blue Ridge Mountains in western North Carolina, USA, which is in a region that lacks good chronological data. Lower hillslopes, alluvial/...

  17. Screening for therapeutic trials and treatment indication in clinical practice: MACK-3, a new blood test for the diagnosis of fibrotic NASH.

    PubMed

    Boursier, J; Anty, R; Vonghia, L; Moal, V; Vanwolleghem, T; Canivet, C M; Michalak, S; Bonnafous, S; Michielsen, P; Oberti, F; Iannelli, A; Van Gaal, L; Patouraux, S; Blanchet, O; Verrijken, A; Gual, P; Rousselet, M-C; Driessen, A; Hunault, G; Bertrais, S; Tran, A; Calès, P; Francque, S

    2018-05-01

    The composite histological endpoint comprising nonalcoholic steatohepatitis (NASH) and NAFLD activity score ≥4 and advanced fibrosis (F ≥ 2) ("fibrotic NASH") is becoming an important diagnostic target in NAFLD: it is currently used to select patients for inclusion in phase III therapeutic trials and will ultimately be used to indicate treatment in clinical practice once the new drugs are approved. To develop a new blood test specifically dedicated for this new diagnostic target of interest. Eight Hundred and forty-six biopsy-proven NAFLD patients from three centres (Angers, Nice, Antwerp) were randomised into derivation and validation sets. The blood fibrosis tests BARD, NFS and FIB4 had poor accuracy for fibrotic NASH with respective AUROC: 0.566 ± 0.023, 0.654 ± 0.023, 0.732 ± 0.021. In the derivation set, fibrotic NASH was independently predicted by AST, HOMA and CK18; all three were combined in the new blood test MACK-3 (hoMa, Ast, CK18) for which 90% sensitivity and 95% specificity cut-offs were calculated. In the validation set, MACK-3 had a significantly higher AUROC (0.847 ± 0.030, P ≤ 0.002) than blood fibrosis tests. Using liver biopsy in the grey zone between the two cut-offs (36.0% of the patients), MACK-3 provided excellent accuracy for the diagnosis of fibrotic NASH with 93.3% well-classified patients, sensitivity: 90.0%, specificity: 94.2%, positive predictive value: 81.8% and negative predictive value: 97.0%. The new blood test MACK-3 accurately diagnoses fibrotic NASH. This new test will facilitate patient screening and inclusion in NAFLD therapeutic trials and will enable the identification of patients who will benefit from the treatments once approved. © 2018 John Wiley & Sons Ltd.

  18. Design and rationale for a real-world observational cohort of patients with nonalcoholic fatty liver disease: The TARGET-NASH study.

    PubMed

    Barritt, A S; Gitlin, Norman; Klein, Samuel; Lok, Anna S; Loomba, Rohit; Malahias, Laura; Powell, Margaret; Vos, Miriam B; Weiss, L Michael; Cusi, Kenneth; Neuschwander-Tetri, Brent A; Sanyal, Arun

    2017-10-01

    Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can lead to cirrhosis, hepatocellular carcinoma, and end-stage liver disease. NAFLD comprises the spectrum from simple steatosis (nonalcoholic fatty liver, NAFL), to steatosis with inflammation (nonalcoholic steatohepatitis, NASH). Current primary therapy recommended for NAFLD is weight loss induced by lifestyle modification. The difficulty in achieving this has led to robust pharmacological therapy development. While new drugs may show efficacy in selected phase II/III clinical trial populations, their real-world effectiveness is unknown. TARGET-NASH is a 5-year, longitudinal, observational study of patients with NAFLD designed to evaluate the effectiveness of clinical practice interventions and provide practical information unobtainable in registration trials. A biological specimen repository is included in TARGET-NASH for translational studies of genomics and biomarkers of disease activity. Patients are enrolling at adult and pediatric sites representing multiple specialties. All patients being managed for NAFLD are eligible, whereas those in other NASH registries or clinical trials will be excluded. Enrolled patients range in age from 6 and up and will have 3years of clinical data reviewed. Patient comorbidities, concomitant medications, disease progression and off-label interventions will be assessed, and adverse outcomes, monitored. Confirming the use, safety and effectiveness of NAFLD interventions in children and adults and establishing pragmatic methods of assessing disease progression under real-world conditions are key study outcomes. Ultimately, TARGET-NASH will establish a large, diverse registry of NAFLD patients at academic and community practices to be leveraged to improve health and reduce development of cirrhosis and hepatocellular carcinoma. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Mars Rover Opportunity Panorama of Wharton Ridge

    NASA Image and Video Library

    2016-10-07

    This scene from NASA's Mars Exploration Rover Opportunity shows "Wharton Ridge," which forms part of the southern wall of "Marathon Valley" on the western rim of Endeavour Crater. The full extent of Wharton Ridge is visible, with the floor of Endeavour Crater beyond it and the far wall of the crater in the distant background. Near the right edge of the scene is "Lewis and Clark Gap," through which Opportunity crossed from Marathon Valley to "Bitterroot Valley" in September 2016. Before the rover departed Marathon Valley, its panoramic camera (Pancam) acquired the component images for this scene on Aug. 30, 2016, during the 4,480th Martian day, or sol, of Opportunity's work on Mars. Opportunity's science team chose the ridge's name to honor the memory of Robert A. Wharton (1951-2012), an astrobiologist who was a pioneer in the use of terrestrial analog environments, particularly in Antarctica, to study scientific problems connected to the habitability of Mars. Over the course of his career, he was a visiting senior scientist at NASA Headquarters, vice president for research at the Desert Research Institute, provost at Idaho State University, and president of the South Dakota School of Mines and Technology. The view spans from east-northeast at left to southeast at right. It merges exposures taken through three of the Pancam's color filters, centered on wavelengths of 753 nanometers (near-infrared), 535 nanometers (green) and 432 nanometers (violet). It is presented in approximately true color. http://photojournal.jpl.nasa.gov/catalog/PIA20849

  20. HCV genotype 3 and squamous cell carcinoma antigen (SCCA)-IgM are independently associated with histological features of NASH in HCV-infected patients.

    PubMed

    Martini, A; Fattovich, G; Guido, M; Bugianesi, E; Biasiolo, A; Ieluzzi, D; Gallotta, A; Fassina, G; Merkel, C; Gatta, A; Negro, F; Pontisso, P

    2015-10-01

    Nonalcoholic steatohepatitis (NASH) enhances the risk of progressive liver disease. In chronic hepatitis C (CHC), liver steatosis is frequent, especially in genotype 3, but its clinical significance is debated. As squamous cell carcinoma antigen (SCCA)-IgM has been associated with advanced liver disease and risk of tumour development, we evaluated its occurrence in CHC and the possible relation with NASH at liver biopsy. Using a validated ELISA, serum SCCA-IgM was measured in 91 patients with CHC at the time of liver biopsy performed before antiviral treatment, at the end of treatment and 6 months thereafter, and in 93 HCV-negative patients with histological diagnosis of nonalcoholic fatty liver disease, as controls. SCCA-IgM was detected in 33% of CHC patients and in 4% of controls. This biomarker was found more elevated in CHC patients with histological NASH, and at multivariate analysis, SCCA-IgM and HCV genotype 3 were independently associated with NASH [OR (95% CI): 6.94 (1.21-40) and 27.02 (4.44-166.6)]. As predictors of NASH, HCV genotype 3 and SCCA-IgM had a specificity and a sensitivity of 97% and 44%, and of 95% and 27%, respectively. PPV and NPV were 80% and 86% for HCV genotype 3 vs 73% and 72% for SCCA-IgM. In patients with sustained virologic response to therapy, SCCA-IgM levels decreased significantly, while these remained unchanged in nonresponders. In conclusion, SCCA-IgM is detectable in one-third of patients with CHC and significantly correlates with histological NASH. © 2015 John Wiley & Sons Ltd.

  1. High H2O/Ce of K-rich MORB from Lena Trough and Gakkel Ridge, Arctic Ocean

    NASA Astrophysics Data System (ADS)

    Snow, J. E.; Feig, S. T.

    2014-12-01

    Lena Trough in the Arctic ocean is the oblique spreading continuation of Gakkel Ridge through the Fram Strait (eg Snow et al. 2011). Extreme trace element and isotopic compositions seen in Lena Trough basalt appear to be the enriched end member dominating the geochemistry of the Western Volcanic Zone of the Western Gakkel Ridge as traced by Pb isotopes, K2O/TiO2, Ba/Nb and other isotopic, major and trace element indicators of mixing (Nauret et al., 2011). This is in contrast to neighboring Gakkel Ridge which has been spreading for 50-60 million years. Basalts from Lena Trough also show a pure MORB noble gas signature (Nauret et al., 2010) and peridotites show no evidence of ancient components in their Os isotopes (Lassiter, et al., in press). The major and trace element compositions of the basalts, however are very distinct from MORB, being far more potassic than all but a single locality on the SW Indian Ridge. We determined H2O and trace element composiitions of a suite of 17 basalt glasses from the Central Lena Trough (CLT) and the Gakkel Western Volcanic Zone, including many of those previously analyzed by Nauret et al. (2012). The Western Gakkel glasses have high H2O/Ce for MORB (>300) suggesting a water rich source consistent with the idea that the northernmost Atlantic mantle is enriched in water (Michael et al., 1995). They are within the range of Eastern Gakkel host glasses determined by Wanless et al, 2013. The Lena Trough (CLT) glasses are very rich in water for MORB (>1% H2O) and are among the highest H2O/Ce (>400) ever measured in MORB aside from melt inclusions in olivine. Mantle melting dynamics and melt evolution cannot account for the H2O/Ce variations in MORB, as these elements have similar behavior during melting and crustal evolution. Interestingly, the H2O/K2O ratios in the basalts are only around 1. This is because the K2O levels in the CLT glasses are very high as well relative to REE. The absolutely linear relationship between H2O and K2O

  2. Circulation in the region of the Reykjanes Ridge in June-July 2015

    NASA Astrophysics Data System (ADS)

    Tillys, Petit; Herle, Mercier; Virginie, Thierry

    2017-04-01

    The Reykjanes Ridge is a major topographic feature of the North-Atlantic Ocean lying south of Iceland that strongly influences the pathways of the upper and lower limbs of the meridional overturning cell. The circulation in the vicinity of the Reykjanes Ridge is anticyclonic and characterized by a southwestward flow (the East Reykjanes Ridge Current, ERRC) along the eastern flank and a northeastward flow (the Irminger Current, IC) along the western flank. Even if it is admitted that the ERRC feeds the IC through a cross-ridge flow, details and magnitude of this circulation remain unclear. In this study, the circulation in the region of the Reykjanes Ridge was investigated based on ADCP and CTDO2 measurements carried out from the R/V Thalassa during the RREX cruise, which provided a snapshot of the water mass distribution and circulation during summer 2015. One hydrographic section followed the top of the Reykjanes Ridge between Iceland and 50˚ N and three other sections were carried out perpendicularly to the ridge at 62˚ N, 58.5˚ N and 56˚ N. Geostrophic transports were estimated by combining ADCP and hydrographic data. Those observations were used to provide an estimate of the circulation around the Ridge and to discuss the meridional evolutions of the ERRC and IC transports along the Ridge and their connection to the cross-Ridge flows. The section along the top of the Reykjanes Ridge allowed us to describe the cross ridge exchanges. A westward flow crossed the Ridge between Iceland and 53˚ N. Its top to bottom integrated transport was estimated at 17.7 Sv. Two main passages were identified for the westward crossing. A first passage is located near 57˚ N (Bight Fracture Zone, BFZ) in agreement with previous studies. More surprisingly, a second passage is located near 59˚ N. The top-to-bottom transports of those two main flows were estimated at 6.5 and 8 Sv respectively. The IC and ERRC top-to-bottom integrated transports were maximum at 58.5˚ N and

  3. The geology of the Oceanographer Transform: The ridge-transform intersection

    NASA Astrophysics Data System (ADS)

    Karson, J. A.; Fox, P. J.; Sloan, H.; Crane, K. T.; Kidd, W. S. F.; Bonatti, E.; Stroup, J. B.; Fornari, D. J.; Elthon, D.; Hamlyn, P.; Casey, J. F.; Gallo, D. G.; Needham, D.; Sartori, R.

    1984-06-01

    Seven dives in the submersible ALVIN and four deep-towed (ANGUS) camera lowerings have been made at the eastern ridge-transform intersection of the Oceanographer Transform with the axis of the Mid-Atlantic Ridge. These data constrain our understanding of the processes that create and shape the distinctive morphology that is characteristic of slowly-slipping ridge-transform-ridge plate boundaries. Although the geological relationships observed in the rift valley floor in the study area are similar to those reported for the FAMOUS area, we observe a distinct change in the character of the rift valley floor with increasing proximity to the transform. Over a distance of approximately ten kilometers the volcanic constructional terrain becomes increasingly more disrupted by faulting and degraded by mass wasting. Moreover, proximal to the transform boundary, faults with orientations oblique to the trend of the rift valley are recognized. The morphology of the eastern rift valley wall is characterized by inward-facing scarps that are ridge-axis parallel, but the western rift valley wall, adjacent to the active transform zone, is characterized by a complex fault pattern defined by faults exhibiting a wide range of orientations. However, even for transform parallel faults no evidence for strike-slip displacement is observed throughout the study area and evidence for normal (dip-slip) displacement is ubiquitous. Basalts, semi-consolidated sediments (chalks, debris slide deposits) and serpentinized ultramafic rocks are recovered from localities within or proximal to the rift valley. The axis of accretion-principal transform displacement zone intersection is not clearly established, but appears to be located along the E-W trending, southern flank of the deep nodal basin that defines the intersection of the transform valley with the rift floor.

  4. Obeticholic acid raises LDL-cholesterol and reduces HDL-cholesterol in the Diet-Induced NASH (DIN) hamster model.

    PubMed

    Briand, François; Brousseau, Emmanuel; Quinsat, Marjolaine; Burcelin, Rémy; Sulpice, Thierry

    2018-01-05

    The use of rat and mouse models limits the translation to humans for developing novel drugs targeting nonalcoholic steatohepatitis (NASH). Obeticholic acid (OCA) illustrates this limitation since its dyslipidemic effect in humans cannot be observed in these rodents. Conversely, Golden Syrian hamsters have a lipoprotein metabolism mimicking human dyslipidemia since it does express the cholesteryl ester transfer protein (CETP). We therefore developed a Diet-Induced NASH (DIN) hamster model and evaluated the impact of OCA. Compared with chow fed controls, hamsters fed for 20 weeks with a free-choice (FC) diet, developed obesity, insulin resistance, dyslipidemia and NASH (microvesicular steatosis, inflammation, hepatocyte ballooning and perisinusoidal to bridging fibrosis). After 20 weeks of diet, FC fed hamsters were treated without or with obeticholic acid (15mg/kg/day) for 5 weeks. Although a non-significant trend towards higher dietary caloric intake was observed, OCA significantly lowered body weight after 5 weeks of treatment. OCA significantly increased CETP activity and LDL-C levels by 20% and 27%, and reduced HDL-C levels by 20%. OCA blunted hepatic gene expression of Cyp7a1 and Cyp8b1 and reduced fecal bile acids mass excretion by 64% (P < 0.05). Hamsters treated with OCA showed a trend towards higher scavenger receptor Class B type I (SR-BI) and lower LDL-receptor hepatic protein expression. OCA reduced NAS score for inflammation (P < 0.01) and total NAS score, although not significantly. Compared to mouse and rat models, the DIN hamster replicates benefits and side effects of OCA as observed in humans, and should be useful for evaluating novel drugs targeting NASH. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Geological mapping of the Rainbow Massif, Mid-Atlantic Ridge, 36°14'N

    NASA Astrophysics Data System (ADS)

    Ildefonse, B.; Fouquet, Y.; Hoisé, E.; Dyment, J.; Gente, P.; Thibaud, R.; Bissessur, D.; Yatheesh, V.; Momardream 2008 Scientific Party*, T.

    2008-12-01

    The Rainbow hydrothermal field at 36°14'N on the Mid-Atlantic Ridge is one of the few known sites hosted in ultramafic basement. The Rainbow Massif is located along the non-transform offset between the AMAR and South AMAR second-order ridge segments, and presents the characteristic dome morphology of oceanic core complexes, although no corrugated surface has been observed so far. One of the objectives of Cruises MOMAR DREAM (July 2007, R/V Pourquoi Pas ?; Aug-Sept 2008, R/V Atalante) was to study the petrological and structural context of the hydrothermal system at the scale of the Rainbow Massif. Our geological sampling complements previous ones achieved during Cruises FLORES (1997) and IRIS (2001), and consisted in dredge hauls, and submersible dives by manned submersible Nautile and ROV Victor. The tectonics of the Rainbow Massif is dominated by a N-S trending fault pattern on the western flank of the massif, and a series of SW-NW ridges on its northeastern side. The active hydrothermal site is located in the area were these two systems crosscut. The most abundant recovered rock type is peridotite (harzburgite and dunite) that presents a variety of serpentinization styles and intensity, and a variety of deformation styles (commonly undeformed, sometimes displaying ductile or brittle foliations). Serpentinites are frequently oxidized. Some peridotite samples have melt impregnation textures. Massive chromitite was recovered in one dredge haul. Variously evolved gabbroic rocks were collected as discrete samples or as centimeter to decimeter-thick dikes in peridotites. Basalts and fresh basaltic glass were also sampled in talus and sediments on the southwestern and northeastern flanks of the massif. Our sampling is consistent with the lithological variability encountered in oceanic core complexes along the Mid-Atlantic Ridge and Southwest Indian Ridge. The stockwork of the hydrothermal system has been sampled on the western side of the present-day hydrothermal

  6. Controls on melting at spreading ridges from correlated abyssal peridotite - mid-ocean ridge basalt compositions

    NASA Astrophysics Data System (ADS)

    Regelous, Marcel; Weinzierl, Christoph G.; Haase, Karsten M.

    2016-09-01

    Variations in the volume and major element composition of basalt erupted along the global mid-ocean ridge system have been attributed to differences in mantle potential temperature, mantle composition, or plate spreading rate and lithosphere thickness. Abyssal peridotites, the residues of mantle melting beneath mid-ocean ridges, provide additional information on the melting process, which could be used to test these hypotheses. We compiled a global database of abyssal peridotite compositions averaged over the same ridge segments defined by Gale et al. (2013). In addition, we calculated the distance of each ridge segment to the nearest hotspots. We show that Cr# in spinel in abyssal peridotites is negatively correlated with Na90 in basalts from the same ridge segments on a global scale. Ridge segments that erupt basalts apparently produced by larger degrees of mantle melting are thus underlain by peridotites from which large amounts of melt have been extracted. We find that near-ridge hotspots have a more widespread influence on mid-ocean ridge basalt (MORB) composition and ridge depth than previously thought. However, when these hotspot-influenced ridge segments are excluded, the remaining segments show clear relationships between MORB composition, peridotite composition, and ridge depth with spreading rate. Very slow-spreading ridges (<20 mm/yr) are deeper, erupt basalts with higher Na90, Al90, K90/Ti90, and lower Fe90, Ca90/Al90, and expose peridotites with lower Cr# than intermediate and fast-spreading ridges. We show that away from hotspots, the spreading-rate dependence of the maximum degree of mantle melting inferred from Cr# in peridotites (FM) and the bulk degree of melting inferred from Na90 in basalts (FB) from the same ridge segments is unlikely to be due to variations in mantle composition. Nor can the effects of dynamic mantle upwelling or incomplete melt extraction at low spreading rates satisfactorily explain the observed compositions of abyssal

  7. Persistent shoreline shape induced from offshore geologic framework: Effects of shoreface connected ridges

    USGS Publications Warehouse

    Safak, Ilgar; List, Jeffrey; Warner, John C.; Schwab, William C.

    2017-01-01

    Mechanisms relating offshore geologic framework to shoreline evolution are determined through geologic investigations, oceanographic deployments, and numerical modeling. Analysis of shoreline positions from the past 50 years along Fire Island, New York, a 50 km long barrier island, demonstrates a persistent undulating shape along the western half of the island. The shelf offshore of these persistent undulations is characterized with shoreface-connected sand ridges (SFCR) of a similar alongshore length scale, leading to a hypothesis that the ridges control the shoreline shape through the modification of flow. To evaluate this, a hydrodynamic model was configured to start with the US East Coast and scale down to resolve the Fire Island nearshore. The model was validated using observations along western Fire Island and buoy data, and used to compute waves, currents and sediment fluxes. To isolate the influence of the SFCR on the generation of the persistent shoreline shape, simulations were performed with a linearized nearshore bathymetry to remove alongshore transport gradients associated with shoreline shape. The model accurately predicts the scale and variation of the alongshore transport that would generate the persistent shoreline undulations. In one location, however, the ridge crest connects to the nearshore and leads to an offshore-directed transport that produces a difference in the shoreline shape. This qualitatively supports the hypothesized effect of cross-shore fluxes on coastal evolution. Alongshore flows in the nearshore during a representative storm are driven by wave breaking, vortex force, advection and pressure gradient, all of which are affected by the SFCR.

  8. Foraging swarms as Nash equilibria of dynamic games.

    PubMed

    Özgüler, Arif Bülent; Yildiz, Aykut

    2014-06-01

    The question of whether foraging swarms can form as a result of a noncooperative game played by individuals is shown here to have an affirmative answer. A dynamic game played by N agents in 1-D motion is introduced and models, for instance, a foraging ant colony. Each agent controls its velocity to minimize its total work done in a finite time interval. The game is shown to have a unique Nash equilibrium under two different foraging location specifications, and both equilibria display many features of a foraging swarm behavior observed in biological swarms. Explicit expressions are derived for pairwise distances between individuals of the swarm, swarm size, and swarm center location during foraging.

  9. Biomechanical comparison of a novel engine-driven ridge spreader and conventional ridge splitting techniques.

    PubMed

    Jung, Gyu-Un; Kim, Jun Hwan; Lim, Nam Hun; Yoon, Gil Ho; Han, Ji-Young

    2017-06-01

    Ridge splitting techniques are used for horizontal ridge augmentation in implant dentistry. Recently, a novel engine-driven ridge splitting technique was introduced. This study compared the mechanical forces produced by conventional and engine-driven ridge splitting techniques in porcine mandibles. In 33 pigs, mandibular premolar areas were selected for the ridge splitting procedures, designed as a randomized split-mouth study. The conventional group underwent a chisel-and-mallet procedure (control group, n = 20), and percussive impulse (Newton second, Ns) was measured using a sensor attached to the mallet. In the engine-driven ridge spreader group (test group, n = 23), a load cell was used to measure torque values (Newton centimeter, Ncm). Horizontal acceleration generated during procedures (control group, n = 10 and test group, n = 10) was compared between the groups. After ridge splitting, the alveolar crest width was significantly increased both in the control (1.23 ± 0.45 mm) and test (0.98 ± 0.41 mm) groups with no significant differences between the groups. The average impulse of the control group was 4.74 ± 1.05 Ns. Torque generated by rotation in the test group was 9.07 ± 2.15 Ncm. Horizontal acceleration was significantly less in the test group (0.82 ± 1.05 g) than the control group (64.07 ± 42.62 g) (P < 0.001). Narrow edentulous ridges can be expanded by novel engine-driven ridge spreaders. Within the limits of this study, the results suggested that an engine-driven ridge splitting technique may be less traumatic and less invasive than a conventional ridge splitting technique. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Reconstruction of Plio-Pleistocene paleoceanographic conditions in the western Arctic Ocean based on a Northwind Ridge sediment record.

    NASA Astrophysics Data System (ADS)

    Dipre, G.; Polyak, L.; Ortiz, J. D.; Oti, E.; Kuznetsov, A.

    2017-12-01

    The rapid loss of sea ice in the Arctic Ocean is expected to result in major climatic and hydrographic changes, some of which are already being observed. To better understand these changes, it is necessary to investigate paleoclimatic conditions during times when the Arctic had similarly reduced sea-ice cover. The Pliocene to early Pleistocene period ( 1-5 Ma) may represent the best analog, as the modern Arctic geography had developed with the opening of the Bering Strait (ca. 5-6 Ma), but major Northern Hemisphere glaciations other than Greenland had not fully begun. Here we present an investigation of sediment core HLY0503-03JPC from top of the Northwind Ridge, western Arctic Ocean. This sedimentary record contains uniquely preserved calcareous microfossils through the early Pleistocene according to strontium isotope ages. Based on extrapolation of these ages, the record extends to at least the late Pliocene. We evaluate paleo-sea ice conditions using benthic foraminifera assemblages, similar to a prior study of a nearby core (Polyak et al., 2013), along with physical (sediment optical properties, density, grain size) and chemical (XRF, δ18O, δ13C) proxies to reconstruct paleo-circulation and sediment transport processes. Based on these proxies, the record exhibits a distinct tripartite stratigraphic division. The top unit, recovering the middle to late Quaternary, shows sedimentary impacts of major glaciations and mostly perennial sea ice conditions. The second unit, dated to the early Pleistocene, indicates reduced glacial inputs, mostly seasonal sea ice, and potentially intensified current conditions. Finally, preliminary results for the oldest unit, presumably representing the late Pliocene, suggest a more acidic ocean characterized by low, if any, sea ice presence and increased current activity. As similar conditions (acidification, storminess) are starting to be observed in the changing modern environment, this third unit may provide especially valuable

  11. Ridge of Jagged Peaks on Titan

    NASA Image and Video Library

    2016-07-29

    This synthetic-aperture radar image was obtained by NASA's Cassini spacecraft during its T-120 pass over Titan's southern latitudes on June 7, 2016. The area shown here measures about 40 by 60 miles (70 by 100 kilometers) and is centered at about 60 degrees south latitude, 130 degrees west longitude. Radar illuminates the scene from the left at a 28-degree incidence angle. At the center of the image is a bright feature oriented from upper left to lower right. This is interpreted to be a long ridge with jagged peaks, likely created by methane rainfall erosion. Some of the individual peaks rise about 2,400 feet (800 meters) above the valley floor. The ridge has a considerably gentler slope on its left side (which appears brighter here) than on its right. Frequently, mountains shaped like this on Earth are fractured blocks of the planet's crust, thrusted upward and then tilted, creating a shallow slope on one side and a steeper slope on the fractured, faulted edge. Also presented here is an annotated version of the image, along with a radar image of the Dragoon Mountains in Arizona just east of Tucson. The Dragoon feature represents a tilted fault block, formed by spreading that has occurred across the western U.S., and has a similar shape to that of the Titan ridge. The Dragoon radar image was produced using data from NASA's Shuttle Radar Topography Mission (credit: NASA/JPL-Caltech/NGA). Radar illuminates the scene from the left in that image as well. Titan has displayed many features that are strikingly similar to Earth: lakes, seas, rivers, dunes and mountains. Scientists think it possible that, like Earth, the giant moon's crust has experienced familiar processes of uplift and spreading, followed by erosion. http://photojournal.jpl.nasa.gov/catalog/PIA20709

  12. Polygonal Ridge Networks on Mars

    NASA Astrophysics Data System (ADS)

    Kerber, Laura; Dickson, James; Grosfils, Eric; Head, James W.

    2016-10-01

    Polygonal ridge networks, also known as boxwork or reticulate ridges, are found in numerous locations and geological contexts across Mars. While networks formed from mineralized fractures hint at hot, possibly life-sustaining circulating ground waters, networks formed by impact-driven clasting diking, magmatic dikes, gas escape, or lava flows do not have the same astrobiological implications. Distinguishing the morphologies and geological context of the ridge networks sheds light on their potential as astrobiological and mineral resource sites of interest. The most widespread type of ridge morphology is characteristic of the Nili Fossae and Nilosyrtis region and consists of thin, criss-crossing ridges with a variety of heights, widths, and intersection angles. They are found in ancient Noachian terrains at a variety of altitudes and geographic locations and may be a mixture of clastic dikes, brecciated dikes, and mineral veins. They occur in the same general areas as valley networks and ancient lake basins, but they are not more numerous where these features are concentrated, and can appear in places where they morphologies are absent. Similarly, some of the ridge networks are associated with hydrated mineral detections, but some occur in locations without detections. Smaller, light-toned ridges of variable widths have been found in Gale Crater and other rover sites and are interpreted to be smaller version of the Nili-like ridges, in this case formed by the mineralization of fractures. This type of ridge is likely to be found in many other places on Mars as more high-resolution data becomes available. Hellas Basin is host to a third type of ridge morphology consisting of large, thick, light-toned ridges forming regular polygons at several superimposed scales. While still enigmatic, these are most likely to be the result of sediment-filled fractures. The Eastern Medusae Fossae Formation contains large swaths of a fourth, previously undocumented, ridge network type

  13. Spawning Sites of the Japanese Eel in Relation to Oceanographic Structure and the West Mariana Ridge

    PubMed Central

    Aoyama, Jun; Watanabe, Shun; Miller, Michael J.; Mochioka, Noritaka; Otake, Tsuguo; Yoshinaga, Tatsuki; Tsukamoto, Katsumi

    2014-01-01

    The Japanese eel, Anguilla japonica, spawns within the North Equatorial Current that bifurcates into both northward and southward flows in its westward region, so its spawning location and larval transport dynamics seem important for understanding fluctuations in its recruitment to East Asia. Intensive research efforts determined that Japanese eels spawn along the western side of the West Mariana Ridge during new moon periods, where all oceanic life history stages have been collected, including eggs and spawning adults. However, how the eels decide where to form spawning aggregations is unknown because spawning appears to have occurred at various latitudes. A salinity front formed from tropical rainfall was hypothesized to determine the latitude of its spawning locations, but an exact spawning site was only found once by collecting eggs in May 2009. This study reports on the collections of Japanese eel eggs and preleptocephali during three new moon periods in June 2011 and May and June 2012 at locations indicating that the distribution of lower salinity surface water or salinity fronts influence the latitude of spawning sites along the ridge. A distinct salinity front may concentrate spawning south of the front on the western side of the seamount ridge. It was also suggested that eels may spawn at various latitudes within low-salinity water when the salinity fronts appeared unclear. Eel eggs were distributed within the 150–180 m layer near the top of the thermocline, indicating shallow spawning depths. Using these landmarks for latitude (salinity front), longitude (seamount ridge), and depth (top of the thermocline) to guide the formation of spawning aggregations could facilitate finding mates and help synchronize their spawning. PMID:24551155

  14. Spawning sites of the Japanese eel in relation to oceanographic structure and the West Mariana Ridge.

    PubMed

    Aoyama, Jun; Watanabe, Shun; Miller, Michael J; Mochioka, Noritaka; Otake, Tsuguo; Yoshinaga, Tatsuki; Tsukamoto, Katsumi

    2014-01-01

    The Japanese eel, Anguilla japonica, spawns within the North Equatorial Current that bifurcates into both northward and southward flows in its westward region, so its spawning location and larval transport dynamics seem important for understanding fluctuations in its recruitment to East Asia. Intensive research efforts determined that Japanese eels spawn along the western side of the West Mariana Ridge during new moon periods, where all oceanic life history stages have been collected, including eggs and spawning adults. However, how the eels decide where to form spawning aggregations is unknown because spawning appears to have occurred at various latitudes. A salinity front formed from tropical rainfall was hypothesized to determine the latitude of its spawning locations, but an exact spawning site was only found once by collecting eggs in May 2009. This study reports on the collections of Japanese eel eggs and preleptocephali during three new moon periods in June 2011 and May and June 2012 at locations indicating that the distribution of lower salinity surface water or salinity fronts influence the latitude of spawning sites along the ridge. A distinct salinity front may concentrate spawning south of the front on the western side of the seamount ridge. It was also suggested that eels may spawn at various latitudes within low-salinity water when the salinity fronts appeared unclear. Eel eggs were distributed within the 150-180 m layer near the top of the thermocline, indicating shallow spawning depths. Using these landmarks for latitude (salinity front), longitude (seamount ridge), and depth (top of the thermocline) to guide the formation of spawning aggregations could facilitate finding mates and help synchronize their spawning.

  15. Deformation of Forearcs during Aseismic Ridge Subduction

    NASA Astrophysics Data System (ADS)

    Zeumann, S.; Hampel, A.

    2014-12-01

    Subduction of aseismic oceanic ridges causes considerable deformation of the forearc region. To identify the crucial parameters for forearc deformation we created 3D finite-element models representing both erosive and accretive forearcs as well as migrating and non-migrating ridges. As natural examples we choose the Cocos ridge subducting stationary beneath the erosive margin of Costa Rica and the Nazca and Gagua Ridges that migrate along the erosive Peruvian margin and the accretive accretive Ryukyu margin, respectively. A series of models show that the deformation of the forearc depends on the ridge shape (height, width), on the frictional coupling along the plate interface and the mechanical strength of the forearc. The forearc is uplifted and moved sideward during ridge subduction. Strain components show domains of both, shortening and extension. Along the ridge axis, extension occurs except at the ridge tip, where shortening prevails. The strain component normal to the ridge axis reveals extension at the ridge tip and contraction above the ridge flanks. Shortening and extension increase with increasing ridge height. Higher friction coefficients lead to less extension and more shortening. Accretive wedges show larger indentation at the model trench. For stationary ridges (Cocos Ridge) the deformation pattern of the forearc is symmetric with respect to the ridge axis whereas for migrating ridges (Nazca Ridge, Gagua Ridge) the oblique convergence direction leads to asymmetric deformation of the forearc. In case of ridge migration, uplift occurs at the leading flank of the ridge and subsidence at the trailing flank, in agreement with field observations and analogue models. For a model with a 200-km-wide and 1500-m-high ridge (i.e. similar to the dimensions of the Nazca Ridge), the modelled uplift rate at the southern ridge flank of the ridge is ~1 mm/a, which agrees well with uplift rates of ~0.7 mm/a derived from the elevation of marine terraces in southern Peru.

  16. Transforming the Ordinary into Extraordinary: Gary Nash and the Visions of History

    ERIC Educational Resources Information Center

    Vigilante, David

    2009-01-01

    Through his long career, Gary Nash has been a pioneer in opening the often-stuffy chambers of academia. He has shown a devotion to K-12 teachers throughout the nation and has ventured into their classrooms to observe, to teach, and, yes, to learn. It is all too rare for a noted historian, famous for his many seminal works, to roll up his sleeves…

  17. PROPAGATION AND LINKAGE OF OCEANIC RIDGE SEGMENTS.

    USGS Publications Warehouse

    Pollard, David D.; Aydin, Atilla

    1984-01-01

    An investigation was made of spreading ridges and the development of structures that link ridge segments using an analogy between ridges and cracks in elastic plates. The ridge-propagation force and a path factor that controls propagation direction were calculated for echelon ridge segments propagating toward each other. The ridge-propagation force increases as ridge ends approach but then declines sharply as the ends pass, so ridge segments may overlap somewhat. The sign of the path factor changes as ridge ends approach and pass, so the overlapping ridge ends may diverge and then converge following a hook-shaped path. The magnitudes of shear stresses in the plane of the plate and orientations of maximum shear planes between adjacent ridge segments were calculated to study transform faulting. For different loading conditions simulating ridge push, plate pull, and ridge suction, a zone of intense mechanical interaction between adjacent ridge ends in which stresses are concentrated was identified. The magnitudes of mean stresses in the plane of the plate and orientations of principal stress planes were also calculated.

  18. A Differential Evolution Algorithm Based on Nikaido-Isoda Function for Solving Nash Equilibrium in Nonlinear Continuous Games

    PubMed Central

    He, Feng; Zhang, Wei; Zhang, Guoqiang

    2016-01-01

    A differential evolution algorithm for solving Nash equilibrium in nonlinear continuous games is presented in this paper, called NIDE (Nikaido-Isoda differential evolution). At each generation, parent and child strategy profiles are compared one by one pairwisely, adapting Nikaido-Isoda function as fitness function. In practice, the NE of nonlinear game model with cubic cost function and quadratic demand function is solved, and this method could also be applied to non-concave payoff functions. Moreover, the NIDE is compared with the existing Nash Domination Evolutionary Multiplayer Optimization (NDEMO), the result showed that NIDE was significantly better than NDEMO with less iterations and shorter running time. These numerical examples suggested that the NIDE method is potentially useful. PMID:27589229

  19. Early Cretaceous MORB-type basalt and A-type rhyolite in northern Tibet: Evidence for ridge subduction in the Bangong-Nujiang Tethyan Ocean

    NASA Astrophysics Data System (ADS)

    Fan, Jian-Jun; Li, Cai; Sun, Zhen-Ming; Xu, Wei; Wang, Ming; Xie, Chao-Ming

    2018-04-01

    New zircon U-Pb ages, major- and trace-element data, and Hf isotopic compositions are presented for bimodal volcanic rocks of the Zhaga Formation (ZF) in the western-middle segment of the Bangong-Nujiang suture zone (BNSZ), northern Tibet. The genesis of these rocks is described, and implications for late-stage evolution of the Bangong-Nujiang Tethyan Ocean (BNTO) are considered. Detailed studies show that the ZF bimodal rocks, which occur as layers within a typical bathyal to abyssal flysch deposit, comprise MORB-type basalt that formed at a mid-ocean ridge, and low-K calc-alkaline A-type rhyolite derived from juvenile crust. The combination of MORB-type basalt, calc-alkaline A-type rhyolite, and bathyal to abyssal flysch deposits in the ZF leads us to propose that they formed as a result of ridge subduction. The A-type ZF rhyolites yield LA-ICP-MS zircon U-Pb ages of 118-112 Ma, indicating formation during the Early Cretaceous. Data from the present study, combined with regional geological data, indicate that the BNTO underwent conversion from ocean opening to ocean closure during the Late Jurassic-Early Cretaceous. The eastern segment of the BNTO closed during this period, while the western and western-middle segments were still at least partially open and active during the Early Cretaceous, accompanied by ridge subduction within the Bangong-Nujiang Tethyan Ocean.

  20. High prevalence of normal serum albumin in NASH patients with ascites: a retrospective analysis.

    PubMed

    Sourianarayanane, Achuthan; O'Shea, Robert S; Barnes, David S; McCullough, Arthur J

    2013-06-01

    Ascites usually occurs in the setting of end-stage liver disease and low serum albumin and is associated with increased mortality. However, some patients develop ascites despite normal serum albumin (NSA), when a higher portal pressure and/or enhanced renal sodium retention would be expected. This study investigated the relationship between the hepatic venous pressure gradient (HVPG) and serum albumin in ascitic patients with different etiologies of cirrhosis and mortality. Records of all patients with non-malignant ascites who underwent HVPG measurement from 2005 to 2009 were reviewed. One hundred and thirty-eight 138 patients met inclusion criteria; 18.8% had NSA. No difference in sodium excretion or diuretic use was noted in patients with and without NSA. NASH patients were more likely to have a NSA (34.2% vs 12.4%; P=0.001) as well as lower HVPG (15 vs 17.9 mmHg; P=0.009) compared to other etiologies. MELD and HVPG predicted overall survival. However, mortality did not differ by disease etiology, though NASH patients had lower CTP (7.6 vs 8.5; P<0.001) and MELD (15.6 vs 18.1; P=0.09) scores, particularly among patients who died. In patients with ascites and NSA, there were no increase in HVPG or urinary sodium retention. NASH patients with ascites had lower HVPG and a higher prevalence of NSA. They also had a higher mortality relative to MELD and CTP scores in other patients. In these patients, mechanisms other than portal and oncotic pressures and sodium retention play a role in ascites development, and increase mortality rate when complicated by low albumin. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  1. Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).

    PubMed

    Jha, Pooja; Knopf, Astrid; Koefeler, Harald; Mueller, Michaela; Lackner, Carolin; Hoefler, Gerald; Claudel, Thierry; Trauner, Michael

    2014-07-01

    Methionine-choline-deficient (MCD) diet is a widely used dietary model of non-alcoholic steatohepatitis (NASH) in rodents. However, the contribution of adipose tissue to MCD-induced steatosis, and inflammation as features of NASH are not fully understood. The goal of this study was to elucidate the role of adipose tissue fatty acid (FA) metabolism, adipogenesis, lipolysis, inflammation and subsequent changes in FA profiles in serum and liver in the pathogenesis of steatohepatitis. We therefore fed ob/ob mice with control or MCD diet for 5 weeks. MCD-feeding increased adipose triglyceride lipase and hormone sensitive lipase activities in all adipose depots which may be attributed to increased systemic FGF21 levels. The highest lipase enzyme activity was exhibited by visceral WAT. Non-esterified fatty acid (NEFA)-18:2n6 was the predominantly elevated FA species in serum and liver of MCD-fed ob/ob mice, while overall serum total fatty acid (TFA) composition was reduced. In contrast, an overall increase of all FA species from TFA pool was found in liver, reflecting the combined effects of increased FA flux to liver, decreased FA oxidation and decrease in lipase activity in liver. NAFLD activity score was increased in liver, while WAT showed no changes and BAT showed even reduced inflammation. This study demonstrates a key role for adipose tissue lipases in the pathogenesis of NASH and provides a comprehensive lipidomic profiling of NEFA and TFA homeostasis in serum and liver. Our findings provide novel mechanistic insights for the role of WAT in progression of MCD-induced liver injury. Copyright © 2014. Published by Elsevier B.V.

  2. Late Quaternary stratigraphy and sedimentation patterns in the western Arctic Ocean

    USGS Publications Warehouse

    Polyak, L.; Bischof, J.; Ortiz, J.D.; Darby, D.A.; Channell, J.E.T.; Xuan, C.; Kaufman, D.S.; Lovlie, R.; Schneider, D.A.; Eberl, D.D.; Adler, R.E.; Council, E.A.

    2009-01-01

    Sediment cores from the western Arctic Ocean obtained on the 2005 HOTRAX and some earlier expeditions have been analyzed to develop a stratigraphic correlation from the Alaskan Chukchi margin to the Northwind and Mendeleev-Alpha ridges. The correlation was primarily based on terrigenous sediment composition that is not affected by diagenetic processes as strongly as the biogenic component, and paleomagnetic inclination records. Chronostratigraphic control was provided by 14C dating and amino-acid racemization ages, as well as correlation to earlier established Arctic Ocean stratigraphies. Distribution of sedimentary units across the western Arctic indicates that sedimentation rates decrease from tens of centimeters per kyr on the Alaskan margin to a few centimeters on the southern ends of Northwind and Mendeleev ridges and just a few millimeters on the ridges in the interior of the Amerasia basin. This sedimentation pattern suggests that Late Quaternary sediment transport and deposition, except for turbidites at the basin bottom, were generally controlled by ice concentration (and thus melt-out rate) and transportation distance from sources, with local variances related to subsurface currents. In the long term, most sediment was probably delivered to the core sites by icebergs during glacial periods, with a significant contribution from sea ice. During glacial maxima very fine-grained sediment was deposited with sedimentation rates greatly reduced away from the margins to a hiatus of several kyr duration as shown for the Last Glacial Maximum. This sedimentary environment was possibly related to a very solid ice cover and reduced melt-out over a large part of the western Arctic Ocean.

  3. Fine-Branched Ridges

    NASA Image and Video Library

    2015-10-14

    This image from NASA Mars Reconnaissance Orbiter spacecraft shows numerous branching ridges with various degrees of sinuosity. These branching forms resemble tributaries funneling and draining into larger channel trunks towards the upper portion of the scene. The raised relief of these branching ridges suggests that these are ancient channels are inverted due to lithification and cementation of the riverbed sediment, which made it more resistant to erosion than the surrounding material. Wind-blown bedforms are abundant and resemble small ridges that are aligned in an approximately north-south direction. http://photojournal.jpl.nasa.gov/catalog/PIA20006

  4. Fingermark ridge drift.

    PubMed

    De Alcaraz-Fossoul, Josep; Roberts, Katherine A; Feixat, Carme Barrot; Hogrebe, Gregory G; Badia, Manel Gené

    2016-01-01

    Distortions of the fingermark topography are usually considered when comparing latent and exemplar fingerprints. These alterations are characterized as caused by an extrinsic action, which affects entire areas of the deposition and alters the overall flow of a series of contiguous ridges. Here we introduce a novel visual phenomenon that does not follow these principles, named fingermark ridge drift. An experiment was designed that included variables such as type of secretion (eccrine and sebaceous), substrate (glass and polystyrene), and degrees of exposure to natural light (darkness, shade, and direct light) indoors. Fingermarks were sequentially visualized with titanium dioxide powder, photographed and analyzed. The comparison between fresh and aged depositions revealed that under certain environmental conditions an individual ridge could randomly change its original position regardless of its unaltered adjacent ridges. The causes of the drift phenomenon are not well understood. We believe it is exclusively associated with intrinsic natural aging processes of latent fingermarks. This discovery will help explain the detection of certain dissimilarities at the minutiae/ridge level; determine more accurate "hits"; identify potentially erroneous corresponding points; and rethink identification protocols, especially the criteria of "no single minutiae discrepancy" for a positive identification. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  5. Contextual view of Point Bonita Ridge, showing Bonita Ridge access ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Point Bonita Ridge, showing Bonita Ridge access road retaining wall and location of Signal Corps Radar (S.C.R.) 296 Station 5 Transmitter Building foundation (see stake at center left), camera facing north - Fort Barry, Signal Corps Radar 296, Station 5, Transmitter Building Foundation, Point Bonita, Marin Headlands, Sausalito, Marin County, CA

  6. Cenozoic tectono-thermal history of the Tordrillo Mountains, Alaska: Paleocene-Eocene ridge subduction, decreasing relief, and late Neogene faulting

    USGS Publications Warehouse

    Benowitz, Jeff A.; Haeussler, Peter J.; Layer, Paul W.; O'Sullivan, Paul B.; Wallace, Wes K.; Gillis, Robert J.

    2012-01-01

    Topographic development inboard of the continental margin is a predicted response to ridge subduction. New thermochronology results from the western Alaska Range document ridge subduction related orogenesis. K-feldspar thermochronology (KFAT) of bedrock samples from the Tordrillo Mountains in the western Alaska Range complement existing U-Pb, 40Ar/39Ar and AFT (apatite fission track) data to provide constraints on Paleocene pluton emplacement, and cooling as well as Late Eocene to Miocene vertical movements and exhumation along fault-bounded blocks. Based on the KFAT analysis we infer rapid exhumation-related cooling during the Eocene in the Tordrillo Mountains. Our KFAT cooling ages are coeval with deposition of clastic sediments in the Cook Inlet, Matanuska Valley and Tanana basins, which reflect high-energy depositional environments. The Tordrillo Mountains KFAT cooling ages are also the same as cooling ages in the Iliamna Lake region, the Kichatna Mountains of the western Alaska Range, and Mt. Logan in the Wrangell-St. Elias Mountains, thus rapid cooling at this time encompasses a broad region inboard of, and parallel to, the continental margin extending for several hundred kilometers. We infer these cooling events and deposition of clastic rocks are related to thermal effects that track the eastward passage of a slab window in Paleocene-Eocene time related to the subduction of the proposed Resurrection-Kula spreading ridge. In addition, we conclude that the reconstructed KFATmax negative age-elevation relationship is likely related to a long period of decreasing relief in the Tordrillo Mountains.

  7. Changing characteristics of arctic pressure ridges

    NASA Astrophysics Data System (ADS)

    Wadhams, Peter; Toberg, Nick

    2012-04-01

    The advent of multibeam sonar permits us to obtain full three-dimensional maps of the underside of sea ice. In particular this enables us to distinguish the morphological characteristics of first-year (FY) and multi-year (MY) pressure ridges in a statistically valid way, whereas in the past only a small number of ridges could be mapped laboriously by drilling. In this study pressure ridge distributions from two parts of the Arctic Ocean are compared, in both the cases using mainly data collected by the submarine “Tireless” in March 2007 during two specific grid surveys, in the Beaufort Sea at about 75° N, 140° W (N of Prudhoe Bay), and north of Ellesmere Island at about 83° 20‧ N, 64° W. In the Beaufort Sea the ice was mainly FY, and later melted or broke up as this area became ice-free during the subsequent summer. N of Ellesmere Island the ice was mainly MY. Ridge depth and spacing distributions were derived for each region using the boat's upward looking sonar, combined with distributions of shapes of the ridges encountered, using the Kongsberg EM3002 multibeam sonar. The differing shapes of FY and MY ridges are consistent with two later high-resolution multibeam studies of specific ridges by AUV. FY ridges are found to fit the normal triangular shape template in cross-section (with a range of slope angles averaging 27°) with a relatively constant along-crest depth, and often a structure of small ice blocks can be distinguished. MY ridges, however, are often split into a number of independent solid, smooth blocks of large size, giving an irregular ridge profile which may be seemingly without linearity. Our hypothesis for this difference is that during its long lifetime an MY ridge is subjected to several episodes of crack opening; new cracks in the Arctic pack often run in straight lines across the ridges and undeformed ice alike. Such a crack will open somewhat before refreezing, interpolating a stretch of thin ice into the structure, and breaking up

  8. Variational Ridging in Sea Ice Models

    NASA Astrophysics Data System (ADS)

    Roberts, A.; Hunke, E. C.; Lipscomb, W. H.; Maslowski, W.; Kamal, S.

    2017-12-01

    This work presents the results of a new development to make basin-scale sea ice models aware of the shape, porosity and extent of individual ridges within the pack. We have derived an analytic solution for the Euler-Lagrange equation of individual ridges that accounts for non-conservative forces, and therefore the compressive strength of individual ridges. Because a region of the pack is simply a collection of paths of individual ridges, we are able to solve the Euler-Lagrange equation for a large-scale sea ice field also, and therefore the compressive strength of a region of the pack that explicitly accounts for the macro-porosity of ridged debris. We make a number of assumptions that have simplified the problem, such as treating sea ice as a granular material in ridges, and assuming that bending moments associated with ridging are perturbations around an isostatic state. Regardless of these simplifications, the ridge model is remarkably predictive of macro-porosity and ridge shape, and, because our equations are analytic, they do not require costly computations to solve the Euler-Lagrange equation of ridges on the large scale. The new ridge model is therefore applicable to large-scale sea ice models. We present results from this theoretical development, as well as plans to apply it to the Regional Arctic System Model and a community sea ice code. Most importantly, the new ridging model is particularly useful for pinpointing gaps in our observational record of sea ice ridges, and points to the need for improved measurements of the evolution of porosity of deformed ice in the Arctic and Antarctic. Such knowledge is not only useful for improving models, but also for improving estimates of sea ice volume derived from altimetric measurements of sea ice freeboard.

  9. Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPAR{alpha} with clofibrate

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Donthamsetty, Shashikiran; Bhave, Vishakha S.; Mitra, Mayurranjan S.

    2008-08-01

    The objective was to investigate if the hepatotoxic sensitivity in nonalcoholic steatohepatitic mice to acetaminophen (APAP) is due to downregulation of nuclear receptor PPAR{alpha} via lower cell division and tissue repair. Male Swiss Webster mice fed methionine and choline deficient diet for 31 days exhibited NASH. On the 32nd day, a marginally toxic dose of APAP (360 mg/kg, ip) yielded 70% mortality in steatohepatitic mice, while all non steatohepatitic mice receiving the same dose survived. {sup 14}C-APAP covalent binding, CYP2E1 protein, and enzyme activity did not differ from the controls, obviating increased APAP bioactivation as the cause of amplified APAPmore » hepatotoxicity. Liver injury progressed only in steatohepatitic livers between 6 and 24 h. Cell division and tissue repair assessed by {sup 3}H-thymidine incorporation and PCNA were inhibited only in the steatohepatitic mice given APAP suggesting that higher sensitivity of NASH liver to APAP-induced hepatotoxicity was due to lower tissue repair. The hypothesis that impeded liver tissue repair in steatohepatitic mice was due to downregulation of PPAR{alpha} was tested. PPAR{alpha} was downregulated in NASH. To investigate whether downregulation of PPAR{alpha} in NASH is the critical mechanism of compromised liver tissue repair, PPAR{alpha} was induced in steatohepatitic mice with clofibrate (250 mg/kg for 3 days, ip) before injecting APAP. All clofibrate pretreated steatohepatitic mice receiving APAP exhibited lower liver injury, which did not progress and the mice survived. The protection was not due to lower bioactivation of APAP but due to higher liver tissue repair. These findings suggest that inadequate PPAR{alpha} expression in steatohepatitic mice sensitizes them to APAP hepatotoxicity.« less

  10. Strange bedfellows - A deep-water hermatypic coral reef superimposed on a drowned barrier island; Southern Pulley Ridge, SW Florida platform margin

    USGS Publications Warehouse

    Jarrett, B.D.; Hine, A.C.; Halley, R.B.; Naar, D.F.; Locker, S.D.; Neumann, A.C.; Twichell, D.; Hu, C.; Donahue, B.T.; Jaap, W.C.; Palandro, D.; Ciembronowicz, K.

    2005-01-01

    The southeastern component of a subtle ridge feature extending over 200 km along the western ramped margin of the south Florida platform, known as Pulley Ridge, is composed largely of a non-reefal, coastal marine deposit. Modern biostromal reef growth caps southern Pulley Ridge (SPR), making it the deepest hermatypic reef known in American waters. Subsurface ridge strata are layered, lithified, and display a barrier island geomorphology. The deep-water reef community is dominated by platy scleractinian corals, leafy green algae, and coralline algae. Up to 60% live coral cover is observed in 60-75 m of water, although only 1-2% of surface light is available to the reef community. Vertical reef accumulation is thin and did not accompany initial ridge submergence during the most recent sea-level rise. The delayed onset of reef growth likely resulted from several factors influencing Gulf waters during early stages of the last deglaciation (???14 kyr B.P.) including; cold, low-salinity waters derived from discrete meltwater pulses, high-frequency sea-level fluctuations, and the absence of modern oceanic circulation patterns. Currently, reef growth is supported by the Loop Current, the prevailing western boundary current that impinges upon the southwest Florida platform, providing warm, clear, low-nutrient waters to SPR. The rare discovery of a preserved non-reefal lowstand shoreline capped by rich hermatypic deep-reef growth on a tectonically stable continental shelf is significant for both accurate identification of late Quaternary sea-level position and in better constraining controls on the depth limits of hermatypic reefs and their capacity for adaptation to extremely low light levels. ?? 2004 Elsevier B.V. All rights reserved.

  11. Bowers Swell: Evidence for a zone of compressive deformation concentric with Bowers Ridge, Bering Sea

    USGS Publications Warehouse

    Marlow, M. S.; Cooper, A. K.; Dadisman, S.V.; Geist, E.L.; Carlson, P.R.

    1990-01-01

    Bowers Swell is a newly discovered bathymetric feature which is up to 90 m high, between 12 and 20 km wide, and which extends arcuately about 400 km along the northern and eastern sides of Bowers Ridge. The swell was first revealed on GLORIA sonographs and subsequently mapped on seismic reflection and 3.5 kHz bathymetric profiles. These geophysical data show that the swell caps an arcuate anticlinal ridge, which is composed of deformed strata in an ancient trench on the northern and eastern sides of Bowers Ridge. The trench fill beneath the swell is actively deforming, as shown by faulting of the sea floor and by thinning of the strata across the crest of the swell. Thinning and faulting of the trench strata preclude an origin for the swell by simple sediment draping over an older basement high. We considered several models for the origin of Bowers Swell, including folding and uplift of the underlying trench sediment during the interaction between the Pacific plate beneath the Aleutian Ridge and a remnant oceanic slab beneath Bowers Ridge. However, such plate motions should generate extensive seismicity beneath Bowers Ridge, which is aseismic, and refraction data do not show any remnant slab beneath Bowers Ridge. Another origin considered for Bowers Swell invokes sediment deformation resulting from differential loading and diapirism in the trench fill. However, diapirism is not evident on seismic reflection profiles across the swell. We favour a model in which sediment deformation and swell formation resulted from a few tens of kilometers of low seismicity motion by intraplate crustal blocks beneath the Aleutian Basin. This motion may result from the translation of blocks in western Alaska to the south-west, forcing the movement of the Bering Sea margin west of Alaska into the abyssal Aleutian Basin. ?? 1990.

  12. Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice.

    PubMed

    Honda, Takashi; Ishigami, Masatoshi; Luo, Fangqiong; Lingyun, Ma; Ishizu, Yoji; Kuzuya, Teiji; Hayashi, Kazuhiko; Nakano, Isao; Ishikawa, Tetsuya; Feng, Guo-Gang; Katano, Yoshiaki; Kohama, Tomoya; Kitaura, Yasuyuki; Shimomura, Yoshiharu; Goto, Hidemi; Hirooka, Yoshiki

    2017-04-01

    For successful treatment for nonalcoholic steatohepatitis (NASH), it may be important to treat the individual causative factors. At present, however, there is no established treatment for this disease. Branched-chain amino acids (BCAAs) have been used to treat patients with decompensated cirrhosis. In order to elucidate the mechanisms responsible for the effects of BCAAs on hepatic steatosis and disease progression, we investigated the effects of BCAA supplementation in mice fed a choline-deficient high-fat diet (CDHF), which induces NASH. Male mice were divided into four groups that received (1) choline-sufficient high fat (HF) diet (HF-control), (2) HF plus 2% BCAA in drinking water (HF-BCAA), (3) CDHF diet (CDHF-control), or (4) CDHF-BCAA for 8weeks. We monitored liver injury, hepatic steatosis and cholesterol, gene expression related to lipid metabolism, and hepatic fat accumulation. Serum alanine aminotransferase (ALT) levels and hepatic triglyceride (TG) were significantly elevated in CDHF-control relative to HF-control. Liver histopathology revealed severe steatosis, inflammation, and pericellular fibrosis in CDHF-control, confirming the NASH findings. Serum ALT levels and hepatic TG and lipid droplet areas were significantly lower in CDHF-BCAA than in CDHF-control. Gene expression and protein level of fatty acid synthase (FAS), which catalyzes the final step in fatty acid biosynthesis, was significantly decreased in CDHF-BCAA than in CDHF-control (P<0.05). Moreover, hepatic total and free cholesterol of CDHF-BCAA was significantly lower than those of CDHF-control. BCAA can alleviate hepatic steatosis and liver injury associated with NASH by suppressing FAS gene expression and protein levels. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Ridge Jumps Associated with Plume-Ridge Interaction 1: Off-axis Heating due to Lithospheric Magma Penetration

    NASA Astrophysics Data System (ADS)

    Mittelstaedt, E.; Ito, G.

    2005-12-01

    In many hot spot-ridge systems, changes in the ridge axis geometry occur between the hot spot centers and nearby mid-ocean ridges in the form of ridge jumps. Such ridge jumps likely occur as a result of anomalous lithospheric stresses associated with mantle plume-lithosphere interaction, as well as weakening of the hot spot lithosphere due to physical and thermal thinning caused by rising buoyant asthenosphere and magma transport through the lithosphere. In this study, we use numerical models to quantify the effects of excess magmatism through the near-ridge lithosphere. Hot spot magmatism can weaken the lithosphere both mechanically through fracturing and thermally through conduction and advection of heat into the plate. Here we focus on the effects of thermal weakening. Using a plane-strain approximation, we examine deformation in a 2-D cross section of a visco-elastic-plastic lithosphere with the finite element code FLAC. The model has isothermal top and bottom boundaries and a prescribed velocity equal to the half spreading rate is imposed on the sides to drive seafloor spreading. The initial condition, as predicted for normal mid-ocean ridges, is a square root of lithospheric age cooling curve with a corner flow velocity field symmetric about the ridge axis. A range of heat inputs are introduced at various plate ages and spreading rates to simulate off-axis magma transport. To reveal the physical conditions that allow for a ridge jump and control its timing, we vary 4 parameters: spreading rate, lithospheric age, crustal thickness and heat input. Results indicate that the heating rate required to produce a ridge jump increases as a function of lithospheric age at the location of magma intrusion. The time necessary for a ridge jump to develop in lithosphere of a particular age decreases with increasing crustal thicknesses. For magma fluxes comparable to those estimated for Galapagos and Iceland, lithospheric heating by the penetrating magma alone is sufficient

  14. 27 CFR 9.182 - Ribbon Ridge.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Ribbon Ridge. (a) Name. The name of the viticultural area described in this section is “Ribbon Ridge.” (b) Approved Maps. The appropriate maps used to determine the boundaries of the Ribbon Ridge viticultural area... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Ribbon Ridge. 9.182...

  15. 27 CFR 9.182 - Ribbon Ridge.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Ribbon Ridge. (a) Name. The name of the viticultural area described in this section is “Ribbon Ridge.” (b) Approved Maps. The appropriate maps used to determine the boundaries of the Ribbon Ridge viticultural area... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Ribbon Ridge. 9.182...

  16. A Metabolomic Analysis of Omega-3 Fatty Acid-Mediated Attenuation of Western Diet-Induced Nonalcoholic Steatohepatitis in LDLR -/- Mice

    PubMed Central

    Depner, Christopher M.; Traber, Maret G.; Bobe, Gerd; Kensicki, Elizabeth; Bohren, Kurt M.; Milne, Ginger; Jump, Donald B.

    2013-01-01

    Background Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk factor for cirrhosis, hepatocellular carcinoma and liver failure. Previously, we reported that dietary docosahexaenoic acid (DHA, 22:6,n-3) was more effective than eicosapentaenoic acid (EPA, 20:5,n-3) at reversing western diet (WD) induced NASH in LDLR-/- mice. Methods Using livers from our previous study, we carried out a global non-targeted metabolomic approach to quantify diet-induced changes in hepatic metabolism. Results Livers from WD + olive oil (WD + O)-fed mice displayed histological and gene expression features consistent with NASH. The metabolomic analysis of 320 metabolites established that the WD and n-3 polyunsaturated fatty acid (PUFA) supplementation had broad effects on all major metabolic pathways. Livers from WD + O-fed mice were enriched in saturated (SFA) and monounsaturated fatty acids (MUFA), palmitoyl-sphingomyelin, cholesterol, n-6 PUFA, n-6 PUFA-containing phosphoglycerolipids, n-6 PUFA-derived oxidized lipids (12-HETE) and depleted of C20-22 n-3 PUFA-containing phosphoglycerolipids, C20-22 n-3 PUFA-derived oxidized lipids (18-HEPE, 17,18-DiHETE) and S-lactoylglutathione, a methylglyoxal detoxification product. WD + DHA was more effective than WD + EPA at attenuating WD + O-induced changes in NASH gene expression markers, n-6 PUFA and oxidized lipids, citrate and S-lactosyl glutathione. Diet-induced changes in hepatic MUFA and sphingolipid content were associated with changes in expression of enzymes involved in MUFA and sphingolipid synthesis. Changes in hepatic oxidized fatty acids and S-lactoylglutathione, however, correlated with hepatic n-3 and n-6 C20-22 PUFA content. Hepatic C20-22 n-3 PUFA content was inversely associated with hepatic α-tocopherol and ascorbate content and positively associated with urinary F2- and F3-isoprostanes, revealing diet effects on whole body oxidative stress. Conclusion DHA regulation of

  17. A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice.

    PubMed

    Depner, Christopher M; Traber, Maret G; Bobe, Gerd; Kensicki, Elizabeth; Bohren, Kurt M; Milne, Ginger; Jump, Donald B

    2013-01-01

    Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk factor for cirrhosis, hepatocellular carcinoma and liver failure. Previously, we reported that dietary docosahexaenoic acid (DHA, 22:6,n-3) was more effective than eicosapentaenoic acid (EPA, 20:5,n-3) at reversing western diet (WD) induced NASH in LDLR(-/-) mice. Using livers from our previous study, we carried out a global non-targeted metabolomic approach to quantify diet-induced changes in hepatic metabolism. Livers from WD + olive oil (WD + O)-fed mice displayed histological and gene expression features consistent with NASH. The metabolomic analysis of 320 metabolites established that the WD and n-3 polyunsaturated fatty acid (PUFA) supplementation had broad effects on all major metabolic pathways. Livers from WD + O-fed mice were enriched in saturated (SFA) and monounsaturated fatty acids (MUFA), palmitoyl-sphingomyelin, cholesterol, n-6 PUFA, n-6 PUFA-containing phosphoglycerolipids, n-6 PUFA-derived oxidized lipids (12-HETE) and depleted of C20-22 n-3 PUFA-containing phosphoglycerolipids, C20-22 n-3 PUFA-derived oxidized lipids (18-HEPE, 17,18-DiHETE) and S-lactoylglutathione, a methylglyoxal detoxification product. WD + DHA was more effective than WD + EPA at attenuating WD + O-induced changes in NASH gene expression markers, n-6 PUFA and oxidized lipids, citrate and S-lactosyl glutathione. Diet-induced changes in hepatic MUFA and sphingolipid content were associated with changes in expression of enzymes involved in MUFA and sphingolipid synthesis. Changes in hepatic oxidized fatty acids and S-lactoylglutathione, however, correlated with hepatic n-3 and n-6 C20-22 PUFA content. Hepatic C20-22 n-3 PUFA content was inversely associated with hepatic α-tocopherol and ascorbate content and positively associated with urinary F2- and F3-isoprostanes, revealing diet effects on whole body oxidative stress. DHA regulation of hepatic SFA, MUFA, PUFA

  18. Moho depth variations over the Maldive Ridge and adjoining Arabian and Central Indian Basins, Western Indian Ocean, from three dimensional inversion of gravity anomalies

    NASA Astrophysics Data System (ADS)

    Kunnummal, Priyesh; Anand, S. P.; Haritha, C.; Rama Rao, P.

    2018-05-01

    Analysis of high resolution satellite derived free air gravity data has been undertaken in the Greater Maldive Ridge (GMR) (Maldive Ridge, Deep Sea Channel, northern limit of Chagos Bank) segment of the Chagos Laccadive Ridge and the adjoining Arabian and Central Indian Basins. A Complete Bouguer Anomaly (CBA) map was generated from the Indian Ocean Geoidal Low removed Free Air Gravity (hereinafter referred to as "FAG-IOGL") data by incorporating Bullard A, B and C corrections. Using the Parker method, Moho topography was initially computed by inverting the CBA data. From the CBA the Mantle Residual Gravity Anomalies (MRGA) were computed by incorporating gravity effects of sediments and lithospheric temperature and pressure induced anomalies. Further, the MRGA was inverted to get Moho undulations from which the crustal thickness was also estimated. It was found that incorporating the lithospheric thermal and pressure anomaly correction has provided substantial improvement in the computed Moho depths especially in the oceanic areas. But along the GMR, there was not much variation in the Moho thickness computed with and without the thermal and pressure gravity correction implying that the crustal thickness of the ridge does not depend on the oceanic isochrones used for the thermal corrections. The estimated Moho depths in the study area ranges from 7 km to 28 km and the crustal thickness from 2 km to 27 km. The Moho depths are shallower in regions closer to Central Indian Ridge in the Arabian Basin i.e., the region to the west of the GMR is thinner compared to the region in the east (Central Indian Basin). The thickest crust and the deepest Moho are found below the N-S trending GMR segment of the Chagos-Laccadive Ridge. Along the GMR the crustal thickness decreases from north to south with thickness of 27 km below the Maldives Ridge reducing to ∼9 km at 3°S and further increasing towards Chagos Bank. Even though there are similarities in crustal thickness between

  19. Tracking paleo-SMT positions using a magnetic susceptibility proxy approach from sediments on the Arctic Vestnesa Ridge, offshore western Svalbard

    NASA Astrophysics Data System (ADS)

    Johnson, Joel; Phillips, Stephen; Panieri, Giuliana; Sauer, Simone; Knies, Jochen; Mienert, Jurgen

    2014-05-01

    Methane in marine sediments, often existing ephemerally as gas hydrate, constitutes one of the largest reservoirs of natural gas on Earth and fluxes of methane in marine sediments are an important component in the global carbon cycle. Tracking changes in past methane flux, however, remains difficult and there are few available proxies that persist through geologic time. CAGE - Centre for Arctic Gas Hydrate, Environment, and Climate initiates a ten year interdisciplinary research and education program aimed at achieving a quantitative understanding of feedbacks between methane in sub-seabed reservoirs, the seabed and the ocean. In our recent work on the Indian continental margin we document that drawdowns in magnetic susceptibility, constrained by magnetic properties, and integrated with core sedimentology, XRF elemental data, authigenic mineralogy, and pore water geochemistry, can be used to track the paleo-positions of the SMT (sulfate-methane transition). Relative positions of the SMT in marine sediments are controlled by the balance of methane and sulfate fluxes. The products of the anaerobic oxidation of methane at the SMT, hydrogen sulfide and bicarbonate, allow for the dissolution of detrital magnetite, and the precipitation of authigenic carbonates and iron sulfides. We recently obtained 21 gravity cores in and between active and inactive pockmarks along the crest of the Vestnesa Ridge, an Arctic gas and gas hydrate bearing contourite sediment drift located offshore western Svalbard. Magnetic susceptibility records from reference cores outside of pockmarks show the stratigraphy across the ridge is quite uniform, whereas magnetic susceptibility records within the pockmarks, with and without observed water column gas flares, are significantly depleted. Integration of multiple data sets from these records and comparison with reconstructions of paleo-methane emissions at the seafloor from benthic foraminifera will allow us to interpret these drawdowns in

  20. Oak Ridge fault, Ventura fold belt, and the Sisar decollement, Ventura basin, California

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yeats, R.S.; Huftile, G.J.; Grigsby, F.B.

    1988-12-01

    The rootless Ventura Avenue, San Miguelito, and Rincon anticlines (Ventura fold belt) in Pliocene -Pleistocene turbidites are fault-propagation folds related to south-dipping reverse faults rising from a decollement in Miocene shale. To the east, the Sulfur Mountain anticlinorium overlies and is cut by the Sisar, Big Canyon, and Lion south-dipping thrusts that merge downward into the Sisar decollement in lower Miocene shale. Shortening of the Miocene and younger sequence is {approximately} 3 km greater than that of underlying competent Paleogens strata in the Ventura fold belt and {approximately} 7 km greater farther east at Sulfur Mountain. Cross-section balancing requires thatmore » this difference be taken up by the Paleogene sequence at the Oak Ridge fault to the south. Convergence is northeast to north-northeast on the base of earthquake focal mechanisms, borehole breakouts, and piercing-point offest of the South Mountain seaknoll by the Oak Ridge fault. A northeast-trending line connecting the west end of Oak Ridge and the east end of Sisar fault separates an eastern domain where late Quaternary displacement is taken up entirely on the Oak Ridge fault and a western domain where displacement is transferred to the Sisar decollement and its overlying rootless folds. This implies that (1) the Oak Ridge fault near the coast presents as much seismic risk as it does farther east, despite negligible near-surface late Quaternary movement; (2) ground-rupture hazard is high for the Sisar fault set in the upper Ojai Valley; and (3) the decollement itself could produce an earthquake analogous to the 1987 Whittier Narrows event in Low Angeles.« less

  1. Geodetic investigation of plate spreading along a propagating ridge: the Eastern Volcanic Zone, Iceland

    NASA Astrophysics Data System (ADS)

    Scheiber-Enslin, Stephanie E.; Lafemina, Peter C.; Sturkell, Erik; Hooper, Andrew J.; Webb, Susan J.

    2011-12-01

    Hotspot-ridge interactions lead to the dynamic evolution of divergent plate boundaries, including propagating and overlapping ridge segments. In southern Iceland, the Eastern Volcanic Zone (EVZ) formed approximately 2-3 Ma ago during the last eastward ridge jump from the Western Volcanic Zone (WVZ), and is propagating to the southwest into the Tertiary lithosphere of the Eastern Volcanic Flank Zone. North America-Eurasia relative plate motion is partitioned between the Eastern and WVZs. We utilize new terrestrial (dry-tilt) and space (GPS and InSAR) geodetic data to investigate the nature of plate spreading and magma-tectonic interaction at the southern terminus of this propagating ridge system. We present a new GPS derived horizontal velocity field covering the period 1994-2006, new InSAR analyses for the periods 1993-2000 and 2003-2007, and models of plate spreading across this region. The velocity field indicates horizontal surface deformation consistent with plate spreading across and the propagation of the EVZ. The dry-tilt and InSAR data show transient deformation signals associated with magmatic processes. The velocity field is corrected for these transient deformation sources in order to investigate the nature of secular plate motion. Our model results indicate a decrease in spreading rate from northeast (15 mm yr-1) to southwest (9 mm yr-1) across the Torfajökull caldera and the intersection of the South Iceland Seismic Zone and EVZ, consistent with the propagating ridge model. Plate spreading south of the intersection demonstrates that spreading must be partitioned with the Reykjanes Peninsula to the west at this latitude. Our results also constrain the minimum flux (0.05 km3 km-1 kyr-1) of magma to this segment of the Mid-Atlantic Ridge and indicate that the Hekla magmatic system strains the Torfajökull caldera during pre- and co-eruptive periods.

  2. Environmental baseline survey report for West Black Oak Ridge, East Black Oak Ridge, McKinney Ridge, West Pine Ridge and parcel 21D in the vicinity of the East Technology Park, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    King, David A.

    2012-11-29

    This environmental baseline survey (EBS) report documents the baseline environmental conditions of five land parcels located near the U.S. Department of Energy?s (DOE?s) East Tennessee Technology Park (ETTP), including West Black Oak Ridge, East Black Oak Ridge, McKinney Ridge, West Pine Ridge, and Parcel 21d. Preparation of this report included the detailed search of federal government records, title documents, aerial photos that may reflect prior uses, and visual inspections of the property and adjacent properties. Interviews with current employees involved in, or familiar with, operations on the real property were also conducted to identify any areas on the property wheremore » hazardous substances and petroleum products, or their derivatives, and acutely hazardous wastes may have been released or disposed. In addition, a search was made of reasonably obtainable federal, state, and local government records of each adjacent facility where there has been a release of any hazardous substance or any petroleum product or their derivatives, including aviation fuel and motor oil, and which is likely to cause or contribute to a release of any hazardous substance or any petroleum product or its derivatives, including aviation fuel or motor oil, on the real property. A radiological survey and soil/sediment sampling was conducted to assess baseline conditions of Parcel 21d that were not addressed by the soils-only no-further-investigation (NFI) reports. Groundwater sampling was also conducted to support a Parcel 21d decision. Based on available data West Black Oak Ridge, East Black Oak Ridge, McKinney Ridge, and West Pine Ridge are not impacted by site operations and are not subject to actions per the Federal Facility Agreement (FFA). This determination is supported by visual inspections, records searches and interviews, groundwater conceptual modeling, approved NFI reports, analytical data, and risk analysis results. Parcel 21d data, however, demonstrate impacts from

  3. Ridges and tidal stress on Io

    USGS Publications Warehouse

    Bart, G.D.; Turtle, E.P.; Jaeger, W.L.; Keszthelyi, L.P.; Greenberg, R.

    2004-01-01

    Sets of ridges of uncertain origin are seen in twenty-nine high-resolution Galileo images, which sample seven locales on Io. These ridges are on the order of a few kilometers in length with a spacing of about a kilometer. Within each locale, the ridges have a consistent orientation, but the orientations vary from place to place. We investigate whether these ridges could be a result of tidal flexing of Io by comparing their orientations with the peak tidal stress orientations at the same locations. We find that ridges grouped near the equator are aligned either north-south or east-west, as are the predicted principal stress orientations there. It is not clear why particular groups run north-south and others east-west. The one set of ridges observed far from the equator (52?? S) has an oblique azimuth, as do the tidal stresses at those latitudes. Therefore, all observed ridges have similar orientations to the tidal stress in their region. This correlation is consistent with the hypothesis that tidal flexing of Io plays an important role in ridge formation. ?? 2004 Elsevier Inc. All rights reserved.

  4. Ridge 2000 Data Management System

    NASA Astrophysics Data System (ADS)

    Goodwillie, A. M.; Carbotte, S. M.; Arko, R. A.; Haxby, W. F.; Ryan, W. B.; Chayes, D. N.; Lehnert, K. A.; Shank, T. M.

    2005-12-01

    Hosted at Lamont by the marine geoscience Data Management group, mgDMS, the NSF-funded Ridge 2000 electronic database, http://www.marine-geo.org/ridge2000/, is a key component of the Ridge 2000 multi-disciplinary program. The database covers each of the three Ridge 2000 Integrated Study Sites: Endeavour Segment, Lau Basin, and 8-11N Segment. It promotes the sharing of information to the broader community, facilitates integration of the suite of information collected at each study site, and enables comparisons between sites. The Ridge 2000 data system provides easy web access to a relational database that is built around a catalogue of cruise metadata. Any web browser can be used to perform a versatile text-based search which returns basic cruise and submersible dive information, sample and data inventories, navigation, and other relevant metadata such as shipboard personnel and links to NSF program awards. In addition, non-proprietary data files, images, and derived products which are hosted locally or in national repositories, as well as science and technical reports, can be freely downloaded. On the Ridge 2000 database page, our Data Link allows users to search the database using a broad range of parameters including data type, cruise ID, chief scientist, geographical location. The first Ridge 2000 field programs sailed in 2004 and, in addition to numerous data sets collected prior to the Ridge 2000 program, the database currently contains information on fifteen Ridge 2000-funded cruises and almost sixty Alvin dives. Track lines can be viewed using a recently- implemented Web Map Service button labelled Map View. The Ridge 2000 database is fully integrated with databases hosted by the mgDMS group for MARGINS and the Antarctic multibeam and seismic reflection data initiatives. Links are provided to partner databases including PetDB, SIOExplorer, and the ODP Janus system. Improved inter-operability with existing and new partner repositories continues to be

  5. 75 FR 41518 - Match-E-Be-Nash-She-Wish (Gun Lake) Tribe Liquor Control Ordinance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... ethyl alcohol, hydrated oxide of ethyl, or spirit of wine, commonly produced by the fermentation or... benefit of the Tribe. (j) ``Tribe'' means the Match-E-Be-Nash-She-Wish Band of Pottawatomi Indians of... and wine shall be purchased from distributors licensed by the Michigan Liquor Control Commission. (f...

  6. Mid-ocean ridge jumps associated with hotspot magmatism

    NASA Astrophysics Data System (ADS)

    Mittelstaedt, Eric; Ito, Garrett; Behn, Mark D.

    2008-02-01

    Hotspot-ridge interaction produces a wide range of phenomena including excess crustal thickness, geochemical anomalies, off-axis volcanic ridges and ridge relocations or jumps. Ridges are recorded to have jumped toward many hotspots including, Iceland, Discovery, Galápagos, Kerguelen and Tristan de Cuhna. The causes of ridge jumps likely involve a number of interacting processes related to hotspots. One such process is reheating of the lithosphere as magma penetrates it to feed near-axis volcanism. We study this effect by using the hybrid, finite-element code, FLAC, to simulate two-dimensional (2-D, cross-section) viscous mantle flow, elasto-plastic deformation of the lithosphere and heat transport in a ridge setting near an off-axis hotspot. Heating due to magma transport through the lithosphere is implemented within a hotspot region of fixed width. To determine the conditions necessary to initiate a ridge jump, we vary four parameters: hotspot magmatic heating rate, spreading rate, seafloor age at the location of the hotspot and ridge migration rate. Our results indicate that the hotspot magmatic heating rate required to initiate a ridge jump increases non-linearly with increasing spreading rate and seafloor age. Models predict that magmatic heating, itself, is most likely to cause jumps at slow spreading rates such as at the Mid-Atlantic Ridge on Iceland. In contrast, despite the higher magma flux at the Galápagos hotspot, magmatic heating alone is probably insufficient to induce a ridge jump at the present-day due to the intermediate ridge spreading rate of the Galápagos Spreading Center. The time required to achieve a ridge jump, for fixed or migrating ridges, is found to be on the order of 10 5-10 6 years. Simulations that incorporate ridge migration predict that after a ridge jump occurs the hotspot and ridge migrate together for time periods that increase with magma flux. Model results also suggest a mechanism for ridge reorganizations not related to

  7. Navigable networks as Nash equilibria of navigation games.

    PubMed

    Gulyás, András; Bíró, József J; Kőrösi, Attila; Rétvári, Gábor; Krioukov, Dmitri

    2015-07-03

    Common sense suggests that networks are not random mazes of purposeless connections, but that these connections are organized so that networks can perform their functions well. One function common to many networks is targeted transport or navigation. Here, using game theory, we show that minimalistic networks designed to maximize the navigation efficiency at minimal cost share basic structural properties with real networks. These idealistic networks are Nash equilibria of a network construction game whose purpose is to find an optimal trade-off between the network cost and navigability. We show that these skeletons are present in the Internet, metabolic, English word, US airport, Hungarian road networks, and in a structural network of the human brain. The knowledge of these skeletons allows one to identify the minimal number of edges, by altering which one can efficiently improve or paralyse navigation in the network.

  8. HLY0602: An integrated geophysical and geological study of the western Canada Basin

    NASA Astrophysics Data System (ADS)

    Lawver, L.; Davis, M.; van Avendonk, H.; Hornbach, M.; Vermeesch, P.; Henkart, M.; Henkart, P.

    2006-12-01

    The USCGC Healy cruise, HLY0602, departed Barrow on 19 July 2006 and ended prematurely on the 22nd of August in Nome, Alaska. HLY0602 was an integrated geophysical and geological study of the western Canada Basin including Northwind Ridge, Chukchi Cap and the Mendeleev Ridge. The IBCAO chart of Arctic bathymetry (Jakobsson, et al., 2000) gives the impression that there is comprehensive bathymetric coverage of the western Canada Basin. While in general, the IBCAO coverage is accurate, there are a number of places where multibeam data indicate significant discrepancies. For instance, the large north-south trough on the eastern margin of Chukchi Cap at 163°W appears on the IBCAO map to have a possible seamount on the eastern edge of the trough at 77.9°N. We surveyed that region and found an extremely flat-floored trough with a depth of 2708 ± 5 m with no sign of a seamount within 10 km of where it is shown on the IBCAO map. On Chukchi Cap there is an apparent ~ 900 m deep trough in the center that is in fact no deeper than ~ 700 m. Multibeam bathymetric surveying of Mendeleev Ridge confirmed the numerous pockmarks found by HLY0504 with even greater concentrations of the pockmarks found to the south along Mendeleev Ridge. A number of major slump features were found on the northern margin of Arlis Plateau at the southern end of Mendeleev Ridge. If the pockmarks are associated with high gas content, then the level of organic rich sediments may be similar to those found on the Lomonosov Ridge by IODP drilling (Backman et al., 2006). Backman, J., Moran, K., McInroy, D.B., Mayer, L.A., and the Expedition 302 Scientists, 2006. Proc. IODP, 302: Edinburgh (Integrated Ocean Drilling Program Management International, Inc.). doi:10.2204/iodp.proc.302.2006 Jakobsson, M., Cherkis, N.Z., Woodward, J., Coakley, B., Macnab, R., 2000. A new grid of Arctic bathymetry: a significant resorce for scientists and mapmakers. EOS Transactions 81(9), 89, 93, 96.

  9. Ridge Regression Signal Processing

    NASA Technical Reports Server (NTRS)

    Kuhl, Mark R.

    1990-01-01

    The introduction of the Global Positioning System (GPS) into the National Airspace System (NAS) necessitates the development of Receiver Autonomous Integrity Monitoring (RAIM) techniques. In order to guarantee a certain level of integrity, a thorough understanding of modern estimation techniques applied to navigational problems is required. The extended Kalman filter (EKF) is derived and analyzed under poor geometry conditions. It was found that the performance of the EKF is difficult to predict, since the EKF is designed for a Gaussian environment. A novel approach is implemented which incorporates ridge regression to explain the behavior of an EKF in the presence of dynamics under poor geometry conditions. The basic principles of ridge regression theory are presented, followed by the derivation of a linearized recursive ridge estimator. Computer simulations are performed to confirm the underlying theory and to provide a comparative analysis of the EKF and the recursive ridge estimator.

  10. Sea ice ridging in the eastern Weddell Sea

    NASA Astrophysics Data System (ADS)

    Lytle, V. I.; Ackley, S. F.

    1991-10-01

    In August 1986, sea ice ridge heights and spatial frequency in the eastern Weddell Sea were measured using a ship-based acoustical sounder. Using a minimum ridge sail height of 0.75 m, a total of 933 ridges were measured along a track length of 415 km. The ridge frequency varied from 0.4 to 10.5 ridges km-1. The mean height of the ridges was found to be about 1.1 m regardless of the ridge frequency. These results are compared to other ridging statistics from the Ross Sea and found to be similar. Comparison with Arctic data, however, indicates that the height and frequency of the ridges are considerably less in the Weddell Sea than in the Arctic. Whereas in the Arctic the mean ridge height tends to increase with the ridge frequency, we found that this was not the case in the Weddell Sea, where the mean ridge height remained constant irrespective of the ridge frequency. Estimates of the contribution of deformed ice to the total ice thickness are generally low except for a single 53-km section where the ridge frequency increased by an order of magnitude. This resulted in an increase in the equivalent mean ice thickness due to ridging from 0.04 m in the less deformed areas to 0.45 m in the highly deformed section. These values were found to be consistent with values obtained from drilled profile lines during the same cruise.

  11. [Comparative study of N, P output and eutrophication risk in runoff water in cross ridge and longitudinal ridge].

    PubMed

    Yu, Xing-Xiu; Ma, Qian; Liu, Qian-Jin; Lü, Guo-An

    2011-02-01

    Field in-situ rainfall simulation tests with two rainfall intensities (40 mm x h(-1) and 70 mm x h(-1)), which were conducted at typical sloping cropland in Yimeng mountainous area, were designed to analyze the output characteristics of dissolved inorganic nitrogen, Inorganic-N (NO3(-)-N, NH4(+) -N) and dissolved phosphorus (DP) in runoff water, as well as to compare the eutrophication risk in this water by calculating three ratios of Inorganic-N/DP, NO3(-) -N/DP, and NH4(+)-N/DP, respectively, in cross ridge and longitudinal ridge tillage methods. Results showed that, under the same rainfall intensity, the DP level in runoff water was higher in cross ridge than longitudinal ridge, while the change of different Inorganic-N level between the two tillage methods were not consistent. Cross ridge could effectively reduce runoff and the output rate of Inorganic-N and DP when compared to the longitudinal ridge tillage, which would be more outstanding with the increases of rainfall intensities. The losses of Inorganic-N and DP in runoff water were 43% and 5% less, respectively, in cross ridge than longitudinal ridge at the 40 mm x h(-1) rainfall intensity, and were 68% and 55%, respectively, at 70 mm x h(-1). The higher Inorganic-N/DP and NO3(-) -N/DP ratios suggest that runoff water from either cross ridge or longitudinal ridge tillage have a certain eutrophication risk, which present an increasing trend during the precipitation-runoff process. Compared with longitudinal ridge, cross ridge can not only hinder the increasing trend of eutrophication risk, but also can significantly lower it, and thus effectively reduce the effect of sloping cropland runoff on the eutrophication processes of receiving waters.

  12. Comparison of buried sand ridges and regressive sand ridges on the outer shelf of the East China Sea

    NASA Astrophysics Data System (ADS)

    Wu, Ziyin; Jin, Xianglong; Zhou, Jieqiong; Zhao, Dineng; Shang, Jihong; Li, Shoujun; Cao, Zhenyi; Liang, Yuyang

    2017-06-01

    Based on multi-beam echo soundings and high-resolution single-channel seismic profiles, linear sand ridges in U14 and U2 on the East China Sea (ECS) shelf are identified and compared in detail. Linear sand ridges in U14 are buried sand ridges, which are 90 m below the seafloor. It is presumed that these buried sand ridges belong to the transgressive systems tract (TST) formed 320-200 ka ago and that their top interface is the maximal flooding surface (MFS). Linear sand ridges in U2 are regressive sand ridges. It is presumed that these buried sand ridges belong to the TST of the last glacial maximum (LGM) and that their top interface is the MFS of the LGM. Four sub-stage sand ridges of U2 are discerned from the high-resolution single-channel seismic profile and four strikes of regressive sand ridges are distinguished from the submarine topographic map based on the multi-beam echo soundings. These multi-stage and multi-strike linear sand ridges are the response of, and evidence for, the evolution of submarine topography with respect to sea-level fluctuations since the LGM. Although the difference in the age of formation between U14 and U2 is 200 ka and their sequences are 90 m apart, the general strikes of the sand ridges are similar. This indicates that the basic configuration of tidal waves on the ECS shelf has been stable for the last 200 ka. A basic evolutionary model of the strata of the ECS shelf is proposed, in which sea-level change is the controlling factor. During the sea-level change of about 100 ka, five to six strata are developed and the sand ridges develop in the TST. A similar story of the evolution of paleo-topography on the ECS shelf has been repeated during the last 300 ka.

  13. Wrinkle ridges of Arcadia Planitia, Mars

    NASA Technical Reports Server (NTRS)

    Plescia, J. B.

    1993-01-01

    Wrinkle ridges of Arcadia Planitia were examined to determine their morphology, spatial distribution, and the amount of crustal shortening and strain they accommodate. Ridges trend generally northward, but their orientation and distribution are strongly controlled by the relief of the underlying hobby material. Ridges begin or end at inselbergs of older terrain and are associated with buried craters. Arcadia Planitia ridges have an average width of 3425 m and accommodate an average folding shortening of 3 m and a faulting shortening of 55 m; mean total shortening is 57 m. Three east-west transects were constructed at 20 deg 25 deg and 28 deg N to estimate regional shortening and strain. Average total shortening across the transects is about 900 m, corresponding to a regional compressive strain of 0.06 percent. The total shortening and compression across Arcadia Planitia are less than in Lungae Planum. Faults associated with the Arcadia ridges are inferred to have a westward dip compared with an eastward dip for Lungae Planum ridges. The general levels of compression and symmetric orientation of the ridges suggest a regionally organized stress system.

  14. Navigable networks as Nash equilibria of navigation games

    PubMed Central

    Gulyás, András; Bíró, József J.; Kőrösi, Attila; Rétvári, Gábor; Krioukov, Dmitri

    2015-01-01

    Common sense suggests that networks are not random mazes of purposeless connections, but that these connections are organized so that networks can perform their functions well. One function common to many networks is targeted transport or navigation. Here, using game theory, we show that minimalistic networks designed to maximize the navigation efficiency at minimal cost share basic structural properties with real networks. These idealistic networks are Nash equilibria of a network construction game whose purpose is to find an optimal trade-off between the network cost and navigability. We show that these skeletons are present in the Internet, metabolic, English word, US airport, Hungarian road networks, and in a structural network of the human brain. The knowledge of these skeletons allows one to identify the minimal number of edges, by altering which one can efficiently improve or paralyse navigation in the network. PMID:26138277

  15. Trace elements in ocean ridge basalts

    NASA Technical Reports Server (NTRS)

    Kay, R. W.; Hubbard, N. J.

    1978-01-01

    A study is made of the trace elements found in ocean ridge basalts. General assumptions regarding melting behavior, trace element fractionation, and alteration effects are presented. Data on the trace elements are grouped according to refractory lithophile elements, refractory siderophile elements, and volatile metals. Variations in ocean ridge basalt chemistry are noted both for regional and temporal characteristics. Ocean ridge basalts are compared to other terrestrial basalts, such as those having La/Yb ratios greater than those of chondrites, and those having La/Yb ratios less than those of chondrites. It is found that (1) as compared to solar or chondrite ratios, ocean ridge basalts have low ratios of large, highly-charged elements to smaller less highly-charged elements, (2) ocean ridge basalts exhibit low ratios of volatile to nonvolatile elements, and (3) the transition metals Cr through Zn in ocean ridge basalts are not fractionated more than a factor of 2 or 3 from the chondritic abundance ratios.

  16. Unusual Rocks of the Yap Ridge - Metamorphosed Basal Cumulates of an Arc ?

    NASA Astrophysics Data System (ADS)

    Hawkins, J. W.; Castillo, P. R.; Batiza, R.

    2002-12-01

    The 8 to 9 km deep Yap trench, and adjacent Yap Ridge, extend from the southwest end of the Mariana Trench near 11o N, to near 7o 15' N where the trench swings west to intersect the Palau Trench. Unlike other western Pacific subduction systems, the Yap Ridge rises directly from the trench, it has no forearc, neither a remnant nor active volcanic arc, and no inclined seismic zone. The few seismic events recorded are mainly < 70 km depth. Yap Ridge crest depths range from 2.5 km to emergent; there are no emergent volcanoes. Rocks from the islands Yap and Map, are mainly strongly schistose, amphibole-rich, mafic and ultramafic rocks. Metamorphic lineations, and meter-sized mullions having lenticular cross-sections, define inclined (15o southerly dip) tectonic transport. Yap and Map schists are in greenschist facies (actinolite - chlorite - Na-plagioclase, rare titanite and epidote). Talc - tremolite schists, serpentinite, and chlorite-pyroxenite are less common. Small areas of altered andesite are present; quartz diorite and hornblende-rich gabbro occur as clasts in breccias, bomb craters yielded fragments of basalt and diabase. Scattered blankets of laterite several meters thick, and jungle, obscure many details. Deeper crustal rocks exposed on inner wall of Yap Trench, (5 - 2.5 km depths) include amphibolite (Al-hornblende-andesine-titanite) interlayered with calcite- diopside - grossularite marble, and calc-silicate gneisses. Rocks dredged from Yap Ridge include metabasite similar toYap schists, island arc tholeiite series basalt, basaltic andesite, and 2-PX gabbro. These have late Miocene ages (Beccaluva et al., AGU Mon. 23, 1980). Assuming isochemical behavior for immobile elements, protolith for mafic and ultramafic schists had high Mg# (52-83), CaO/Al2O3 0.7-6, Cr 288-1490, Ni 64-609, Zr 13-145, Y 3-28 (ppm).These data suggest picrite, high-Mg basalt, boninite, or OL-PX rich ultramafic cumulates as parents. REE data, e.g. negative slope and (La/Sm)N 0

  17. Global survey of lunar wrinkle ridge formation times

    NASA Astrophysics Data System (ADS)

    Yue, Z.; Michael, G. G.; Di, K.; Liu, J.

    2017-11-01

    Wrinkle ridges are a common feature of the lunar maria and record subsequent contraction of mare infill. Constraining the timing of wrinkle ridge formation from crater counts is challenging because they have limited areal extent and it is difficult to determine whether superposed craters post-date ridge formation or have alternatively been uplifted by the deformation. Some wrinkle ridges do allow determination to be made. This is possible where a ridge shows a sufficiently steep boundary or scarp that can be identified as deforming an intersecting crater or the crater obliterates the relief of the ridge. Such boundaries constitute only a small fraction of lunar wrinkle ridge structures yet they are sufficiently numerous to enable us to obtain statistically significant crater counts over systems of structurally related wrinkle ridges. We carried out a global mapping of mare wrinkle ridges, identifying appropriate boundaries for crater identification, and mapping superposed craters. Selected groups of ridges were analyzed using the buffered crater counting method. We found that, except for the ridges in mare Tranquilitatis, the ridge groups formed with average ages between 3.5 and 3.1 Ga ago, or 100-650 Ma after the oldest observable erupted basalts where they are located. We interpret these results to suggest that local stresses from loading by basalt fill are the principal agent responsible for the formation of lunar wrinkle ridges, as others have proposed. We find a markedly longer interval before wrinkle ridge formation in Tranquilitatis which likely indicates a different mechanism of stress accumulation at this site.

  18. Mars Rover Opportunity Panorama of Wharton Ridge Enhanced Color

    NASA Image and Video Library

    2016-10-07

    This scene from NASA's Mars Exploration Rover Opportunity shows "Wharton Ridge," which forms part of the southern wall of "Marathon Valley" on the western rim of Endeavour Crater. In this version of the scene the landscape is presented in enhanced color to make differences in surface materials more easily visible The full extent of Wharton Ridge is visible, with the floor of Endeavour Crater beyond it and the far wall of the crater in the distant background. Near the right edge of the scene is "Lewis and Clark Gap," through which Opportunity crossed from Marathon Valley to "Bitterroot Valley" in September 2016. Before the rover departed Marathon Valley, its panoramic camera (Pancam) acquired the component images for this scene on Aug. 30, 2016, during the 4,480th Martian day, or sol, of Opportunity's work on Mars. Opportunity's science team chose the ridge's name to honor the memory of Robert A. Wharton (1951-2012), an astrobiologist who was a pioneer in the use of terrestrial analog environments, particularly in Antarctica, to study scientific problems connected to the habitability of Mars. Over the course of his career, he was a visiting senior scientist at NASA Headquarters, vice president for research at the Desert Research Institute, provost at Idaho State University, and president of the South Dakota School of Mines and Technology. The view spans from east-northeast at left to southeast at right. Color in the scene comes from component images taken through three of the Pancam's color filters, centered on wavelengths of 753 nanometers (near-infrared), 535 nanometers (green) and 432 nanometers (violet). http://photojournal.jpl.nasa.gov/catalog/PIA20850

  19. Benthic megafaunal community structure of cobalt-rich manganese crusts on Necker Ridge

    NASA Astrophysics Data System (ADS)

    Morgan, Nicole B.; Cairns, Stephen; Reiswig, Henry; Baco, Amy R.

    2015-10-01

    In the North Pacific Ocean, the seamounts of the Hawaiian Archipelago and the Mid-Pacific Mountains are connected by Necker Ridge, a 600 km-long feature spanning a depth range of 1400-4000 m. The Necker Ridge is a part of a large area of the central and western Pacific under consideration for cobalt-rich manganese crust mining. We describe the fauna and community structure of the previously unsampled Necker Ridge based on explorations with the submersible Pisces IV. On five pinnacles and a portion of the Ridge ranging from 1400 to 2000 m deep, 27 transects were recorded using HD video, and voucher specimens were collected to aid in species identification. The video was analyzed to identify and count the megafauna found on each transect and to characterize the substrate. Diversity increased from south to north along the feature. There was a significant difference in community structure between southern and northern pinnacles, with southern pinnacles dominated by crinoids of the Family Charitometridae and northern pinnacles dominated by octocorals, especially the Families Isididae and Chrysogorgiidae. DistLM demonstrated a correlation between community structure on the pinnacles and at least six environmental variables, including latitude, sediment cover, and oxygen concentration, but not including depth. The discontinuous and patchy nature of these distinct megafaunal communities highlights growing evidence that cobalt-rich seamounts are highly heterogeneous habitats, and that managing seamounts may require more complex regulations than treating them as a single ecological unit. These results suggest that extensive community analysis should occur at a given site to determine management priority areas, prior to consideration of that site for exploitation of natural resources.

  20. Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial.

    PubMed

    Argo, Curtis K; Patrie, James T; Lackner, Carolin; Henry, Thomas D; de Lange, Eduard E; Weltman, Arthur L; Shah, Neeral L; Al-Osaimi, Abdullah M; Pramoonjago, Patcharin; Jayakumar, Saumya; Binder, Lukas P; Simmons-Egolf, Winsor D; Burks, Sandra G; Bao, Yongde; Taylor, Ann Gill; Rodriguez, Jessica; Caldwell, Stephen H

    2015-01-01

    This study's aim was to assess the histological and metabolic effects of n-3 polyunsaturated fatty acids (PUFAs) vs. placebo while adjusting for the impact of age and weight change in NASH patients. (ClinicalTrials.gov: NCT00681408). Forty-one subjects with non-cirrhotic NASH were enrolled, and 34 completed the study. 17 received n-3 fish oil 3000 mg/day and 17 received placebo daily for 1 year with typical counselling on caloric intake and physical activity for all subjects. N-3- and placebo-treated groups showed no significant difference for the primary end point of NASH activity score (NAS) reduction ⩾ 2 points without fibrosis progression after adjustment for known covariates (n-3, 4/17 (23.5%); placebo, 3/17, (17.6%), p = 0.99). Among subjects with increased or stable weight, n-3 subjects showed a larger decrease in liver fat content by MRI than placebo-treated subjects (p = 0.014 for 2nd quartile, p = 0.003 for 3rd quartile of weight change). N-3 treatment showed significant fat reduction on the paired analysis of image-assisted fat morphometry regardless of weight loss or gain. Exercise capacity remained markedly reduced in all subjects. No independent effects on markers of hepatocyte injury or insulin sensitivity indices were observed. N-3 PUFAs at 3000 mg/day for one year did not lead to an improvement in the primary outcome of histological activity in NASH patients (⩾ 2 point NAS reduction). N-3 led to reduced liver fat by multiple measures. Other metabolic effects were not seen, although no detrimental effects were apparent. Whether longer duration, higher dose, or different composition of n-3 therapy would lead to additional benefits is uncertain. Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  1. Ridge interaction features of the Line Islands

    NASA Astrophysics Data System (ADS)

    Konter, J. G.; Koppers, A. A. P.; Storm, L. P.

    2016-12-01

    The sections of Pacific absolute plate motion history that precede the Hawaii-Emperor and Louisville chains are based on three chains: the Line Islands-Mid-Pacific Mountains, the Hess Rise-Shatsky Rise, and the Marshall Islands-Wake Islands (Rurutu hotspot). Although it has been clear that the Line Islands do not define a simple age progression (e.g. Schlanger et al., 1984), the apparent similarity to the Emperor Seamount geographic trend has been used to extend the overall Hawaii-Emperor track further into the past. However, we show here that plate tectonic reconstructions suggest that the Mid-Pacific Mountains (MPMs) and Line Islands (LIs) were erupted near a mid-ocean ridge, and thus these structures do not reflect absolute plate motion. Moverover, the morphology and geochemistry of the volcanoes show similarities with Pukapuka Ridge (e.g. Davis et al., 2002) and the Rano Rahi seamounts, presumed to have a shallow origin. Modern 40Ar/39Ar ages show that the LIs erupted at various times along the entire volcanic chain. The oldest structures formed within 10 Ma of plate formation. Given the short distance to the ridge system, large aseismic volcanic ridges, such as Necker Ridge and Horizon Guyot may simply reflect a connection between MPMs and the ridge, similar to the Pukapuka Ridge. The Line Islands to the south (including Karin Ridge) define short subchains of elongated seamounts that are widespread, resembling the Rano Rahi seamount field. During this time, the plate moved nearly parallel to the ridge system. The change from few large ridges to many subchains may reflect a change in absolute plate motion, similar to the Rano Rahi field. Here, significant MPMs volcanism is no longer connected to the ridge along plate motion. Similar to Pukapuka vs. Rano Rahi, the difference in direction between plate motion and the closest ridge determines whether larger ridges or smaller seamount subchains are formed. The difference between the largest structures (MPMs and LIs

  2. Periodontal considerations for esthetics: edentulous ridge augmentation.

    PubMed

    Rosenberg, E S; Cutler, S A

    1993-01-01

    Edentulous ridge augmentation is a plastic surgical technique that is performed to improve patient esthetics when unsightly, deformed ridges exist. This article describes the etiology of ridge deformities and the many procedures that can be executed to achieve an esthetic, functional result. Historically, soft-tissue mucogingival techniques were described to augment collapsed ridges. Pedicle grafts, free soft-tissue grafts, and subepithelial connective tissue grafts are predictable forms of therapy. More recently, ridge augmentation techniques were developed that regenerate the lost periodontium. These include allografts, bioglasses, guided tissue regenerative procedures, and tissue expansion.

  3. Modulatory role of Co-enzyme Q10 on methionine and choline deficient diet-induced non-alcoholic steatohepatitis (NASH) in albino rats.

    PubMed

    Saleh, Dalia O; Ahmed, Rania F; Amin, Mohamed M

    2017-03-01

    The present study aimed to evaluate the hepato-protective and neuro-protective activity of Co-enzyme Q10 (CoQ10) on non-alcoholic steatohepatitis (NASH) in albino rats induced by methionine and choline-deficient (MCD) diet. Rats were fed an MCD diet for 8 weeks to induce non-alcoholic steatohepatitis. CoQ10 (10 mg/(kg·day) -1 ) was orally administered for 2 consecutive weeks. Twenty-four hours after the last dose of the drug, the behavioral test, namely the activity cage test, was performed and the activity counts were recorded. Serum alanine transaminase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, total/direct bilirubin, and albumin were valued to assess liver function. Moreover, hepatic cytokines interleukin-6 as well as its modulator nuclear factor kappa-light-chain-enhancer of activated B cells were determined. In addition, brain biomarkers, viz ammonia, nitric oxide, and brain-derived neurotrophic factor (BDNF), were measured as they are reliable indices to assess brain damage. Histopathological and immunohistochemical examination of brain proliferating cell nuclear antigen in brain and liver tissues were also evaluated. Results revealed that MCD-induced NASH showed impairment in the liver functions with an increase in the liver inflammatory markers. Moreover, NASH resulted in pronounced brain dysfunction as evidenced by hyper-locomotor activity, a decrease in the BDNF level, as well as an increase in the brain nitric oxide and ammonia contents. Oral treatment of MCD-diet-fed rats with CoQ10 for 14 days showed a marked improvement in all the assigned parameters. Finally, it can be concluded that CoQ10 has a hepatoprotective and neuroprotective role in MCD-diet-induced NASH in rats.

  4. Effects on Ridge Segmentation, Magmatic Plumbing and Eruption Style Caused by Weak Hot-spot to Ridge Interaction: the Central Indian Ridge and Rodrigues Hot-spot Couplet.

    NASA Astrophysics Data System (ADS)

    Murton, B. J.; Parson, L. M.; Sauter, D.

    2001-12-01

    The intermediate spreading, Central Indian Ridge (CIR) forms a couplet with a weak hot-spot of which the Rodrigues archipelago is an expression. Recently collected bathymetry shows that despite having little in the way of a significant topographic swell, the hot-spot is associated with a change in offset sense across adjacent transforms of the CIR causing the ridge to draw nearer to the Rodrigues island system. The most proximal ridge segment of the CIR is over 20km long and comprises three non-transform bounded sub-segments. The most northerly sub-segment has a shallow (<3000m), narrow (<5km) and featureless flat rift valley. TOBI sidescan sonar imagery shows that the segment is host to a 15km-long, 5km-wide single sheet flow. Elsewhere in the segment the valley floor is characterised by long (>5km), narrow (<1km) ridges that often terminate in conical seamounts. These ridges are the loci of some of the acoustically freshest volcanic facies in the rift valley. Samples recovered from these ridges have similar petrology along strike. With increasing distance south along the CIR, the ridge segments are typically 500m deeper than to the north. Here they are about 75km long and bounded by transform offsets that are 50 km long. However, even in the deepest parts of these segments, where the axial floor is over 4000m deep at the ridge-transform-intersections, there is fresh lava and other evidence for abundant volcanic activity. Within these segments, the rift valley comprises mainly seamounts and hummocky volcanic features. We believe the westward stepping trend of the CIR towards the Rodrigues islands is a function of the hot spot. The elevated temperature and volatile content to the west reduces mantle viscosity which, combined with thinner and hence weaker lithosphere, influencec the loci of initial oceanic rifting and the relative position of the ridge axis. The unusually great length of the northern segment has a similar origin with the presence of thin and weak

  5. Carslberg Ridge and Mid-Atlantic Ridge: Slow-spreading Apparent Analogs

    NASA Astrophysics Data System (ADS)

    Rona, P. A.; Murton, B. J.; Bostrom, K.; Widenfalk, L.; Melson, W. G.; O'Hearn, T.; Cronan, D. S.; Jenkins, W. J.

    2005-12-01

    We compare morphology, tectonics, petrology, and hydrothermal activity of a known section of the Mid-Atlantic Ridge (MAR) between the Kane and Atlantis fracture zones (full multi-beam coverage 21N to 31N) to the lesser known Carlsberg Ridge (CR; limited multi-beam coverage plus satellite altimetry). The CR extends from the Owen Fracture Zone (10N) to the Vityaz Fracture Zone (5S) and spreads at half-rates (~1.2-1.8 cm/yr) similar to the MAR: 1) Morphology: Both ridges exhibit distinct segmentation (primarily sinistral) and axial valleys with high floor to crest relief (range 1122-1771 m). Average lengths of segments (CR: 70 km; MAR: 50 km) and crest-to crest width of the axial valley are greater on the CR (40 km) than MAR (23 km). Axial volcanic ridges form the neovolcanic zone on both ridges, typically 2.6 km wide and 213 m high on the CR. Average water depth near segment centers is greater on the MAR (3933 m) than the CR (3564 m). V-shaped patterns oblique to the spreading axis are present on both ridges. 2) Tectonics: Segments on each ridge are predominantly separated by short-offset (<30 km) non-transform discontinuities with longer transform faults generally spaced hundreds of kilometers apart. Bulls-eye Mantle Bouguer Lows (-30 to -50 mgal) are present at centers of spreading segments on both ridges. Metamorphic core complexes of lower crust and upper mantle are present on the MAR section (at fracture zones) and at least at one locality at 58.33E on the CR. 3) Petrology: MORB composition from our 20 stations along the CR fall into the MORB family, with no evidence of hotspot inputs (no excess K or Nb), or extreme fractionation, similar to the MAR section. REE and trace element patterns between 57E and 61E on the CR indicate increasing melt depletion to the northwest, while glasses exhibit a striking systematic increase in MgO (decrease in fractionation) to the northwest and attain among the most primitive composition of any ocean ridge adjacent to the Owen

  6. Iterative algorithms for computing the feedback Nash equilibrium point for positive systems

    NASA Astrophysics Data System (ADS)

    Ivanov, I.; Imsland, Lars; Bogdanova, B.

    2017-03-01

    The paper studies N-player linear quadratic differential games on an infinite time horizon with deterministic feedback information structure. It introduces two iterative methods (the Newton method as well as its accelerated modification) in order to compute the stabilising solution of a set of generalised algebraic Riccati equations. The latter is related to the Nash equilibrium point of the considered game model. Moreover, we derive the sufficient conditions for convergence of the proposed methods. Finally, we discuss two numerical examples so as to illustrate the performance of both of the algorithms.

  7. Ridge jumps associated with plume-ridge interaction: Mantle plume-lithosphere interaction and hotspot magmatism

    NASA Astrophysics Data System (ADS)

    Mittelstaedt, E.; Ito, G.

    2007-12-01

    Interaction of mantle plumes and young lithosphere near mid-ocean ridges can lead to changes in spreading geometry by shifts of the ridge-axis toward the plume as seen at various hotspots, notably Iceland and the Galapagos. Previous work has shown that, with a sufficient magma flux, heating of the lithosphere by magmatism can significantly weaken the plate and, in some cases, could cause ridge jumps. Upwelling hot asthenosphere can also weaken the plate through thermal and mechanical thinning of the lithosphere. Using the finite element code CITCOM, we solve the equations of continuity, momentum and energy to examine deformation in near-ridge lithosphere associated with relatively hot upwelling asthenosphere and seafloor spreading. The mantle and lithosphere obey a non-Newtonian viscous rheology with plastic failure in the cold part of the lithosphere simulated by imposing an effective yield stress. Temperatures of the lithospheric thermal boundary region are initially given a square-root of age thermal profile while a hot patch is placed at the bottom to initiate a mantle-plume like upwelling. The effect of upwelling asthenosphere on ridge jumps is evaluated by varying three parameters: the plume excess temperature, the spreading rate and the distance of the plume from the ridge axis. Preliminary results show plume related thinning and weakening of the lithosphere over a wide area (100's of km's) with the rate of thinning increasing with the excess temperature of the plume. Initially, thinning occurs as the plume approaches the lithosphere and asthenospheric material is forced out of the way. As the plume material comes into contact with the lithosphere, thinning occurs through heating and mechanical removal of the thermal boundary layer. Thinning of the lithosphere is one of the primary factors in achieving a ridge jump. Another is large tensile stresses which can facilitate the initiation of rifting at this weakened location. Model stresses induced by the

  8. Large-scale deformation associated with ridge subduction

    USGS Publications Warehouse

    Geist, E.L.; Fisher, M.A.; Scholl, D. W.

    1993-01-01

    Continuum models are used to investigate the large-scale deformation associated with the subduction of aseismic ridges. Formulated in the horizontal plane using thin viscous sheet theory, these models measure the horizontal transmission of stress through the arc lithosphere accompanying ridge subduction. Modelling was used to compare the Tonga arc and Louisville ridge collision with the New Hebrides arc and d'Entrecasteaux ridge collision, which have disparate arc-ridge intersection speeds but otherwise similar characteristics. Models of both systems indicate that diffuse deformation (low values of the effective stress-strain exponent n) are required to explain the observed deformation. -from Authors

  9. Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype.

    PubMed

    Farrell, Geoffrey C; Mridha, Auvro R; Yeh, Matthew M; Arsov, Todor; Van Rooyen, Derrick M; Brooling, John; Nguyen, Tori; Heydet, Deborah; Delghingaro-Augusto, Viviane; Nolan, Christopher J; Shackel, Nicholas A; McLennan, Susan V; Teoh, Narci C; Larter, Claire Z

    2014-08-01

    Obese Alms1 mutant (foz/foz) NOD.B10 mice develop diabetes and fibrotic NASH when fed high-fat(HF) diet. To establish whether diabetes or obesity is more closely associated with NASH fibrosis, we compared diabetic foz/foz C57BL6/J with non-diabetic foz/foz BALB/c mice. We also determined hepatic cytokines, growth factors and related profibrotic pathways. Male and female foz/foz BALB/c and C57BL6/J mice were fed HF or chow for 24 weeks before determining metabolic indices, liver injury, cytokines, growth factors, pathology/fibrosis and matrix deposition pathways. All foz/foz mice were obese. Hepatomegaly, hyperinsulinemia, hyperglycaemia and hypoadiponectinaemia occurred only in foz/foz C57BL6/J mice, whereas foz/foz BALB/c formed more adipose. Serum ALT, steatosis, ballooning, liver inflammation and NAFLD activity score were worse in C57BL6/J mice. In HF-fed mice, fibrosis was severe in foz/foz C57BL6/J, appreciable in WT C57BL6/J, but absent in foz/foz BALB/c mice. Hepatic mRNA expression of TNF-α, IL-12, IL-4, IL-10 was increased (but not IFN-γ, IL-1β, IL-17A), and IL-4:IFN-γ ratio (indicating Th-2 predominance) was higher in HF-fed foz/foz C57BL6/J than BALB/c mice. In livers of HF-fed foz/foz C57BL6/J mice, TGF-β was unaltered but PDGFα and CTGF were increased in association with enhanced α-SMA, CD147and MMP activity. In mice with equivalent genetic/dietary obesity, NASH development is linked to strain differences in hyperinsulinaemia and hyperglycaemia inversely related to lipid partitioning between adipose and liver. Diabetes-mediated CTGF-regulation of MMPs as well as cytokines/growth factors (Th-2 cytokine predominant, PDGFα, not TGF-β) mobilized in the resultant hepatic necroinflammatory change may contribute to strain differences in NASH fibrosis. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Earthquake source parameters for the 2010 western Gulf of Aden rifting episode

    NASA Astrophysics Data System (ADS)

    Shuler, Ashley; Nettles, Meredith

    2012-08-01

    On 2010 November 14, an intense swarm of earthquakes began in the western Gulf of Aden. Within a 48-hr period, 82 earthquakes with magnitudes between 4.5 and 5.5 were reported along an ˜80-km-long segment of the east-west trending Aden Ridge, making this swarm one of the largest ever observed in an extensional oceanic setting. In this study, we calculate centroid-moment-tensor solutions for 110 earthquakes that occurred between 2010 November and 2011 April. Over 80 per cent of the cumulative seismic moment results from earthquakes that occurred within 1 week of the onset of the swarm. We find that this sequence has a b-value of ˜1.6 and is dominated by normal-faulting earthquakes that, early in the swarm, migrate westwards with time. These earthquakes are located in rhombic basins along a section of the ridge that was previously characterized by low levels of seismicity and a lack of recent volcanism on the seafloor. Body-wave modelling demonstrates that the events occur in the top 2-3 km of the crust. Nodal planes of the normal-faulting earthquakes are consistent with previously mapped faults in the axial valley. A small number of strike-slip earthquakes observed between two basins near 44°E, where the axial valley changes orientation, depth and width, likely indicate the presence of an incipient transform fault and the early stages of ridge-transform segmentation. The direction of extension accommodated by the earthquakes is intermediate between the rift orthogonal and the direction of relative motion between the Arabian and Somalian plates, consistent with the oblique style of rifting occurring along the slow-spreading Aden Ridge. The 2010 swarm shares many characteristics with dyke-induced rifting episodes from both oceanic and continental settings. We conclude that the 2010 swarm represents the seismic component of an undersea magmatic rifting episode along the nascent Aden Ridge, and attribute the large size of the earthquakes to the combined effects of

  11. Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice.

    PubMed

    Jung, Kwang Hwa; Yoo, Wonbeak; Stevenson, Heather L; Deshpande, Dipti; Shen, Hong; Gagea, Mihai; Yoo, Suk-Young; Wang, Jing; Eckols, T Kris; Bharadwaj, Uddalak; Tweardy, David J; Beretta, Laura

    2017-09-15

    Purpose: The incidence of hepatocellular carcinoma is increasing in the United States, and liver cancer is the second leading cause of cancer-related mortality worldwide. Nonalcoholic steatohepatitis (NASH) is becoming an important risk for hepatocellular carcinoma, and most patients with hepatocellular carcinoma have underlying liver cirrhosis and compromised liver function, which limit treatment options. Thus, novel therapeutic strategies to prevent or treat hepatocellular carcinoma in the context of NASH and cirrhosis are urgently needed. Experimental Design: Constitutive activation of STAT3 is frequently detected in hepatocellular carcinoma tumors. STAT3 signaling plays a pivotal role in hepatocellular carcinoma survival, growth, angiogenesis, and metastasis. We identified C188-9, a novel small-molecule STAT3 inhibitor using computer-aided rational drug design. In this study, we evaluated the therapeutic potential of C188-9 for hepatocellular carcinoma treatment and prevention. Results: C188-9 showed antitumor activity in vitro in three hepatocellular carcinoma cell lines. In mice with hepatocyte-specific deletion of Pten (Hep Pten - mice), C188-9 treatment blocked hepatocellular carcinoma tumor growth, reduced tumor development, and reduced liver steatosis, inflammation, and bile ductular reactions, resulting in improvement of the pathological lesions of NASH. Remarkably, C188-9 also greatly reduced liver injury in these mice as measured by serum aspartate aminotransferase and alanine transaminase levels. Analysis of gene expression showed that C188-9 treatment of Hep Pten - mice resulted in inhibition of signaling pathways downstream of STAT3, STAT1, TREM-1, and Toll-like receptors. In contrast, C188-9 treatment increased liver specification and differentiation gene pathways. Conclusions: Our results suggest that C188-9 should be evaluated further for the treatment and/or prevention of hepatocellular carcinoma. Clin Cancer Res; 23(18); 5537-46. ©2017 AACR

  12. Volcanoclastics of the Walvis Ridge

    NASA Astrophysics Data System (ADS)

    Eroshenko, D. V.; Kharin, G. S.

    2018-03-01

    The paper generalizes the distribution of volcanoclastic material in the Cenozoic sedimentary cover of the Walvis Ridge, made on the basis of the DSDP (Deep Sea Drilling Projects) and ODP (Ocean Drilling Program). The cycles of volcanoclastic accumulation have been distinguished. It has been proved that the distribution of the material in the Paleogene primary reflects the dynamics of volcanism of the ridge itself. The sources of volcanoclastics have been determined. The possibility of the existence of Early Eocene submarine volcanoes in the central part of the ridge has been shown. The dynamics of volcanism of the ridge has been compared with the variability of major climatic markers in sediments, indicating the unity of volcanic processes in the region and processes that led to an increase in the index of 13C content in sediments and CO2 content in the atmosphere.

  13. Structure of the Sumatra wedge affected by the 26th December 2004 :Effects of the lower plate volcanic ridges.

    NASA Astrophysics Data System (ADS)

    Rangin, C.; Sibuet, J. C.; Lin, J. Y.; Le Pichon, X.

    2009-04-01

    Detailed swath-bathymetry, coupled with echo-sounder data were collected offshore the northern tip of Sumatra over the rupture area of the 26th December 2004 Mw=9.2 earthquake during the Sumatra aftershock cruise. 20 ocean bottom seismometers were also deployed in the northern Sumatra area., and more than 1000 events were identified during the 12 days recording period. We mapped recently active steeply dipping thrust fault zone within the western termination of the Sunda accreted wedge. Main N10°W trending out of sequence thrust fault zones with a discrete westward vergency and some component of dextral strike-slip motion were continuously mapped within the wedge, on the basis of bathymetry and low frequency sounder profiles. The interplate boundary does not appear to extend into the frontal part of the wedge but most probably merges in its central part along these major faults, the Lower and Upper Splay Faults. After relocation, the seismicity shows different pattern in each side of this Upper Splay Fault. East of this boundary, beneath the Aceh basin, the earthquake depths ranged from 30 to 60 km allow us to illustrate the subducted plate. In the western part, the aftershock distribution is strongly influenced by the N-S orientated oceanic fracture zones. Two clusters of earthquakes between 10 and 50 km in depth trending along N-S direction are observed in the lower wedge that we interpret to be reactive fracture zones. The lower wedge is interpreted as the northern prolongation below the wedge of the lower plate NS oceanic fracture zone ridges affected by NS trending left lateral strike-slip faults. This wedge outer ridge is in the process of being transferred to the upper plate. On the other hand the central ridge is interpreted as possible stacked volcanic ridge slivers already incorporated into the upper plate along the subduction buttress (the inner ridge of the wedge). We propose that the tectonic interaction of the volcanic Indian Ocean fracture ridges of

  14. Origin of ice-rafted debris: Pleistocene paleoceanography in the western Arctic Ocean

    NASA Astrophysics Data System (ADS)

    Bischof, Jens; Clark, David L.; Vincent, Jean-Serge

    1996-12-01

    The composition of Pleistocene ice-rafted debris (IRD) >250 µm was analyzed quantitatively by grain counting in five sediment cores from the western central Arctic Ocean and compared with the composition of till clasts from NW Canada in order to determine the dropstone origin and to reconstruct the Pleistocene ice driftways and surface currents. The IRD composition alternates repeatedly between carbonate- and quartz-dominated assemblages, along with metamorphic and igneous rocks, clastic rocks, and some chert. The highest quartz content is found on the Alpha Ridge, while carbonate percentages are highest on the Northwind Ridge (NWR) and the Chukchi Cap. The source for the carbonates is the area around Banks and Victoria Islands and parts of northern Canada. Quartz most likely originated from the central Queen Elizabeth Islands. IRD on the southeastern Alpha Ridge is dominated by mafic crystalline rocks from northern Ellesmere Island and northern Greenland. At least six major glacial intervals are identified within the last 1 million years, during which icebergs drifted toward the west in the Beaufort Sea, straight northward in the central Arctic Ocean, and northeastward on the SE Alpha Ridge.

  15. High-resolution estimates of Southwest Indian Ridge plate motions, 20 Ma to present

    NASA Astrophysics Data System (ADS)

    DeMets, C.; Merkouriev, S.; Sauter, D.

    2015-12-01

    We present the first estimates of Southwest Indian Ridge (SWIR) plate motions at high temporal resolution during the Quaternary and Neogene based on nearly 5000 crossings of 21 magnetic reversals out to C6no (19.72 Ma) and the digitized traces of 17 fracture zones and transform faults. Our reconstructions of this slow-spreading mid-ocean ridge reveal several unexpected results with notable implications for regional and global plate reconstructions since 20 Ma. Extrapolations of seafloor opening distances to zero-age seafloor based on reconstructions of reversals C1n (0.78 Ma) through C3n.4 (5.2 Ma) reveal evidence for surprisingly large outward displacement of 5 ± 1 km west of 32°E, where motion between the Nubia and Antarctic plates occurs, but 2 ± 1 km east of 32°E, more typical of most mid-ocean ridges. Newly estimated SWIR seafloor spreading rates are up to 15 per cent slower everywhere along the ridge than previous estimates. Reconstructions of the numerous observations for times back to 11 Ma confirm the existence of the hypothesized Lwandle plate at high confidence level and indicate that the Lwandle plate's western and eastern boundaries respectively intersect the ridge near the Andrew Bain transform fault complex at 32°E and between ˜45°E and 52°E, in accord with previous results. The Nubia-Antarctic, Lwandle-Antarctic and Somalia-Antarctic rotation sequences that best fit many magnetic reversal, fracture zone and transform fault crossings define previously unknown changes in the Neogene motions of all three plate pairs, consisting of ˜20 per cent slowdowns in their spreading rates at 7.2^{+0.9 }_{ -1.4} Ma if we enforce a simultaneous change in motion everywhere along the SWIR and gradual 3°-7° anticlockwise rotations of the relative slip directions. We apply trans-dimensional Bayesian analysis to our noisy, best-fitting rotation sequences in order to estimate less-noisy rotation sequences suitable for use in future global plate reconstructions

  16. Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma

    PubMed Central

    Vongsuvanh, Roslyn; van der Poorten, David; Iseli, Tristan; Strasser, Simone I.; McCaughan, Geoffrey W.; George, Jacob

    2016-01-01

    Robust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin (OPN) and AFP for HCC diagnosis in 86 HCC patients matched to 86 cirrhotics, 86 with chronic liver disease (CLD) and 86 healthy controls (HC). Based on the performance of each biomarker, we assessed a separate longitudinal cohort of 28 HCC patients, at and before cancer diagnosis. Serum levels of MDK and OPN were higher in HCC patients compared to cirrhosis, CLD and HC groups. DKK1 was not different between cases and controls. More than half of HCC patients had normal AFP. In this AFP-negative HCC cohort, 59.18% (n = 29/49) had elevated MDK, applying the optimal cut-off of 0.44 ng/ml. Using AFP ≥ 20 IU/ml or MDK ≥ 0.44 ng/ml, a significantly greater number (76.7%; n = 66/86) of HCC cases were detected. The area under the receiver operating curve for MDK was superior to AFP and OPN in NASH-HCC diagnosis. In the longitudinal cohort, MDK was elevated in 15/28 (54%) of HCC patients at diagnosis, of whom 67% had elevated MDK 6 months prior. Conclusion: AFP and MDK have a complementary role in HCC detection. MDK increases the diagnostic yield in AFP-negative HCC and has greater diagnostic performance than AFP, OPN and DKK-1 in the diagnosis of NASH-HCC. Additionally, MDK has a promising role in the pre-clinical diagnosis of HCC. PMID:27219517

  17. Base-flow characteristics of streams in the Valley and Ridge, Blue Ridge, and Piedmont physiographic provinces of Virginia

    USGS Publications Warehouse

    Nelms, D.L.; Harlow, G.E.; Hayes, Donald C.

    1995-01-01

    Growth within the Valley and Ridge, Blue Ridge, and Piedmont Physiographic Provinces of Virginia has focussed concern about allocation of surface-water flow and increased demands on the ground-water resources. The purpose of this report is to (1) describe the base-flow characteristics of streams, (2) identify regional differences in these flow characteristics, and (3) describe, if possible, the potential surface-water and ground-water yields of basins on the basis of the base-flow character- istics. Base-flow characteristics are presented for streams in the Valley and Ridge, Blue Ridge, and Piedmont Physiographic Provinces of Virginia. The provinces are separated into five regions: (1) Valley and Ridge, (2) Blue Ridge, (3) Piedmont/Blue Ridge transition, (4) Piedmont northern, and (5) Piedmont southern. Different flow statistics, which represent streamflows predominantly comprised of base flow, were determined for 217 continuous-record streamflow-gaging stations from historical mean daily discharge and for 192 partial-record streamflow-gaging stations by means of correlation of discharge measurements. Variability of base flow is represented by a duration ratio developed during this investigation. Effective recharge rates were also calculated. Median values for the different flow statistics range from 0.05 cubic foot per second per square mile for the 90-percent discharge on the streamflow-duration curve to 0.61 cubic foot per second per square mile for mean base flow. An excellent estimator of mean base flow for the Piedmont/Blue Ridge transition region and Piedmont southern region is the 50-percent discharge on the streamflow-duration curve, but tends to under- estimate mean base flow for the remaining regions. The base-flow variability index ranges from 0.07 to 2.27, with a median value of 0.55. Effective recharge rates range from 0.07 to 33.07 inches per year, with a median value of 8.32 inches per year. Differences in the base-flow characteristics exist between

  18. Emergence and petrology of the Mendocino Ridge

    NASA Astrophysics Data System (ADS)

    Fisk, Martin R.; Duncan, Robert A.; Fox, Christopher G.; Witter, Jeffrey B.

    1993-11-01

    The Mendocino Fracture Zone, a 3,000-km-long transform fault, extends from the San Andreas Fault at Cape Mendocino, California due west into the central Pacific basin. The shallow crest of this fracture zone, known as the Mendocino Ridge, rises to within 1,100 m of the sea surface at 270 km west of the California Coast. Rounded basalt pebbles and cobbles, indicative of a beach environment, are the dominant lithology at two locations on the crest of Mendocino Ridge and a40Ar/39 Ar incremental heating age of 11.0 ± 1.0 million years was determined for one of the these cobbles. This basalt must have been erupted on the Gorda Ridge because the crust immediately to the south of the fracture zone is older than 27 Ma. This age also implies that the crest of Mendocino Ridge was at sea level and would have blocked Pacific Ocean eastern boundary currents and affected the climate of the North American continent at some time since the late Miocene. Basalts from the Mendocino Fracture Zone (MFZ) are FeTi basalts similar to those commonly found at intersections of mid-ocean ridges and fracture zones. These basalts are chemically distinct from the nearby Gorda Ridge but they could have been derived from the same mantle source as the Gorda Ridge basalts. The location of the 11 Ma basalt suggests that Mendocino Ridge was transferred from the Gorda Plate to the Pacific Plate and the southern end of Gorda Ridge was truncated by a northward jump in the transform fault of MFZ.

  19. Seafloor tilt induced by ocean tidal loading inferred from broadband seismometer data from the Cascadia subduction zone and Juan de Fuca Ridge

    NASA Astrophysics Data System (ADS)

    Davis, Earl E.; Heesemann, Martin; Lambert, Anthony; He, Jianheng

    2017-04-01

    Mass-balancing voltages from four buried broadband seismometers connected to the NEPTUNE Canada seafloor cable are being recorded at 24-bit resolution. Sites are located on the Vancouver Island continental shelf, the nearby Cascadia accretionary prism, the eastern flank of the Juan de Fuca Ridge, and the western flank close to the Juan de Fuca Ridge axis. Tidal variations are present throughout the records. Variations in vertical acceleration at three of the sites match predicted gravitational attraction variations very well; those at the fourth site show a small residual that is probably caused by sensitivity to tilt resulting from sensor inclination. Horizontal accelerations, which at tidal periods are sensitive primarily to tilt, are anomalously large relative to standard-earth model results. After removal of predicted tidal body and ocean attraction and loading terms, the residuals are seen to follow ocean pressure variations. Responses range from 0.4 μrad dbar-1 (0.04 μrad kPa-1) at 10° true (down under positive load) at the continental shelf site, to 0.6 μrad dbar-1 at 243° at the Cascadia prism, 0.4 μrad dbar-1 at 90° at the eastern Juan de Fuca Ridge flank, and 0.2 μrad dbar-1 at 116° true on the western ridge flank. Except at the continental shelf site, tilts are roughly perpendicular to structural strike. The tilt observations can be explained by loading-induced deformation in the presence of local lithologic gradients or by the influence of faults or structurally controlled anisotropic elastic properties. The observations highlight the utility of using mass position data from force-feedback broad-band seismometers for geodynamic studies.

  20. Hydrothermal Activity Along the Central Indian Ridge: Ridges, Hotspots and Philately.

    NASA Astrophysics Data System (ADS)

    German, C. R.; Connelly, D. P.; Evans, A. J.; Murton, B. J.; Curewitz, D.; Okino, K.; Statham, P. J.; Parson, L. M.

    2001-12-01

    The global mid-ocean ridge crest extends 50-60,000km and the majority remains unexplored for hydrothermal activity. Even those areas which are reasonably familiar continue to spring surprises (e.g. the "Lost City" site found in late 2000). Within the confines of conceivable research budgets, therefore, choosing new areas for investigation and exploration demands an intelligent approach, beyond flicking through holiday brochures or identifying missing entries for the John Edmond Memorial Stamp Collection. With that caveat, the Southampton Oceanography Centre led a 10-week expedition to the Central Indian Ridge, earlier this year, based in and around Mauritius. During cruise CD127 (23 April-23 May) we conducted a systematic investigation of the ridge crest (seafloor and overlying water column) between 18 deg 16 min and 20 deg 49 min South. We chose this area to investigate the distribution of hydrothermal activity both close to, and away from, that section of the ridge crest which continues to reflect past influence of the migrating Rodrigues hot-spot. Our hypothesis was that the high incidence of hydrothermal activity we had located previously, near the Azores Triple Junction, may result from waning influence of the Azores Hot-Spot nearby and that similar effects might be found resulting from interaction of the CIR with the Rodrigues hot-spot. The primary scientific package we employed was the SOC's TOBI deep-tow sidescan vehicle, now up-graded with an extra Light Scattering Sensor string. In concert, this instrumentation allowed us to prospect for particle-laden hydrothermal plumes in the water column overlying the ridge-crest, in real-time, whilst simultaneously acquiring high-resolution sidescan images of the underlying seafloor. Using this approach, particle-rich anomalies were observed at 5 locations along ca. 300km of surveyed ridge-crest, including 4 sites all within the extended (hot-spot influenced) segment 15, which stretches from 18 deg 45 to 20 deg 14

  1. Dark and Bright Ridges on Europa

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This high-resolution image of Jupiter's moon Europa, taken by NASA's Galileo spacecraft camera, shows dark, relatively smooth region at the lower right hand corner of the image which may be a place where warm ice has welled up from below. The region is approximately 30 square kilometers in area. An isolated bright hill stands within it. The image also shows two prominent ridges which have different characteristics; youngest ridge runs from left to top right and is about 5 kilometers in width (about 3.1 miles). The ridge has two bright, raised rims and a central valley. The rims of the ridge are rough in texture. The inner and outer walls show bright and dark debris streaming downslope, some of it forming broad fans. This ridge overlies and therefore must be younger than a second ridge running from top to bottom on the left side of the image. This dark 2 km wide ridge is relatively flat, and has smaller-scale ridges and troughs along its length.

    North is to the top of the picture, and the sun illuminates the surface from the upper left. This image, centered at approximately 14 degrees south latitude and 194 degrees west longitude, covers an area approximately 15 kilometers by 20 kilometers (9 miles by 12 miles). The resolution is 26 meters (85 feet) per picture element. This image was taken on December 16, 1997 at a range of 1300 kilometers (800 miles) by Galileo's solid state imaging system.

    The Jet Propulsion Laboratory, Pasadena, CA manages the Galileo mission for NASA's Office of Space Science, Washington, DC. JPL is an operating division of California Institute of Technology (Caltech).

    This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at URL http://www.jpl.nasa.gov/ galileo.

  2. Bottom-simulating reflector dynamics at Arctic thermogenic gas provinces: An example from Vestnesa Ridge, offshore west Svalbard

    NASA Astrophysics Data System (ADS)

    Plaza-Faverola, A.; Vadakkepuliyambatta, S.; Hong, W.-L.; Mienert, J.; Bünz, S.; Chand, S.; Greinert, J.

    2017-06-01

    The Vestnesa Ridge comprises a >100 km long sediment drift located between the western continental slope of Svalbard and the Arctic mid-ocean ridges. It hosts a deep water (>1000 m) gas hydrate and associated seafloor seepage system. Near-seafloor headspace gas compositions and its methane carbon isotopic signature along the ridge indicate a predominance of thermogenic gas sources feeding the system. Prediction of the base of the gas hydrate stability zone for theoretical pressure and temperature conditions and measured gas compositions results in an unusual underestimation of the observed bottom-simulating reflector (BSR) depth. The BSR is up to 60 m deeper than predicted for pure methane and measured gas compositions with >99% methane. Models for measured gas compositions with >4% higher-order hydrocarbons result in a better BSR approximation. However, the BSR remains >20 m deeper than predicted in a region without active seepage. A BSR deeper than predicted is primarily explained by unaccounted spatial variations in the geothermal gradient and by larger amounts of thermogenic gas at the base of the gas hydrate stability zone. Hydrates containing higher-order hydrocarbons form at greater depths and higher temperatures and contribute with larger amounts of carbons than pure methane hydrates. In thermogenic provinces, this may imply a significant upward revision (up to 50% in the case of Vestnesa Ridge) of the amount of carbon in gas hydrates.

  3. Remedial Investigation Report on Chestnut Ridge Operable Unit 2 (Filled Coal Ash Pond/Upper McCoy Branch) at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. Volume 1. Main Text

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-08-01

    This document is a report on the remedial investigation (RI) of Chestnut Ridge Operable Unit (OU) 2 at the Oak Ridge Y-12 Plant. Chestnut Ridge OU 2 consists of Upper McCoy Branch (UMB), the Filled Coal Ash Pond (FCAP), and the area surrounding the Sluice Channel formerly associated with coal ash disposal in the FCAP. Chestnut Ridge OU 2 is located within the U.S. Department of Energy`s (DOE`s) Oak Ridge Reservation in Anderson County, Tennessee, approximately 24 miles west of Knoxville. The pond is an 8.5-acre area on the southern slope of Chestnut Ridge, 0.5 mile south of the mainmore » Y-12 Plant and geographically separated from the Y-12 Plant by Chestnut Ridge. The elevation of the FCAP is {approximately} 950 ft above mean sea level (msl), and it is relatively flat and largely vegetated. Two small ponds are usually present at the northeast and northwest comers of the FCAP. The Sluice Channel Area extends {approximately}1000 ft from the northern margin of the FCAP to the crest of Chestnut Ridge, which has an elevation of {approximately}1100 ft above msl. The Sluice Channel Area is largely vegetated also. McCoy Branch runs from the top of Chestnut Ridge across the FCAP into Rogers Quarry and out of the quarry where it runs a short distance into Milton Hill Lake at McCoy Embayment, termed UMB. The portion south of Rogers Quarry, within Chestnut Ridge OU 4, is termed Lower McCoy Branch. The DOE Oak Ridge Y-12 Plant disposed of coal ash from its steam plant operations as a slurry that was discharged into an ash retention impoundment; this impoundment is the FCAP. The FCAP was built in 1955 to serve as a settling basin after coal ash slurried over Chestnut Ridge from the Y-12 Plant. The FCAP was constructed by building an earthen dam across the northern tributary of McCoy Branch. The dam was designed to hold 20 years of Y-12 steam plant ash. By July 1967, ash had filled up the impoundment storage behind the dam to within 4 ft of the top.« less

  4. Comprehensive integrated planning: A process for the Oak Ridge Reservation, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1998-05-01

    The Oak Ridge Comprehensive Integrated Plan is intended to assist the US Department of Energy (DOE) and contractor personnel in implementing a comprehensive integrated planning process consistent with DOE Order 430.1, Life Cycle Asset Management and Oak Ridge Operations Order 430. DOE contractors are charged with developing and producing the Comprehensive Integrated Plan, which serves as a summary document, providing information from other planning efforts regarding vision statements, missions, contextual conditions, resources and facilities, decision processes, and stakeholder involvement. The Comprehensive Integrated Plan is a planning reference that identifies primary issues regarding major changes in land and facility use andmore » serves all programs and functions on-site as well as the Oak Ridge Operations Office and DOE Headquarters. The Oak Ridge Reservation is a valuable national resource and is managed on the basis of the principles of ecosystem management and sustainable development and how mission, economic, ecological, social, and cultural factors are used to guide land- and facility-use decisions. The long-term goals of the comprehensive integrated planning process, in priority order, are to support DOE critical missions and to stimulate the economy while maintaining a quality environment.« less

  5. On the Antarctic Slope Front and Current crossing of the South Scotia Ridge

    NASA Astrophysics Data System (ADS)

    Orsi, A. H.; Palmer, M.; Gomis, D.; Flexas, M. M.; Kim, Y.-S.; Jordà, G.; Wiederwohl, C.; Álvarez, M.

    2012-04-01

    To unveil the contorted path followed by the Antarctic Slope Current connecting the Weddell and Scotia Seas, hydrographic stations with unprecedented spatial resolution were occupied on a series of sections across the slope and multiple channels in the double-pronged western portion of the South Scotia Ridge. Fieldwork consisted of two cruises from the ESASSI (January 2008) and ACROSS (February 2009) programs, the Spanish and USA/Argentina components of the International Polar Year core project SASSI (Synoptic Antarctic Shelf-Slope Interaction study). In this region the Antarctic Slope Current can be located by the pronounced in-shore deepening of isopycnals over the continental slope, rendering the strong subsurface temperature and salinity gradients characteristic of the Antarctic Slope Front. Before reaching the gaps in the southern Ridge near 51°W and 50°W, the ASC carries about 3 Sv of upper layer waters, but it splits into shallow and deep branches upon turning north through these two gaps. The shallower branch enters the Hesperides Trough at 51°W, then shows a tight cyclonic loop back to that longitude roughly following the slope's 700-m isobath, and turns again westward through a similar gap in the northern Ridge. In the Scotia Sea the westward-flowing Antarctic Slope Current is found as far west as the Elephant Island along slightly deeper levels of slope (1100 m) before it is blocked by the Antarctic Circumpolar Current south of the Shackleton Fracture Zone (56°W). The deeper branch of the ASC in the Powell Basin crosses the southern Ridge near 50°W and roughly follows the 1600-m isobath before entering the Scotia Sea through the Hesperides Gap farther to the east (49°W). Thereafter the deeper waters carried westward by this branch become undistinguishable from those circulating farther offshore. Repeat cross-slope sections at both southern and northern flanks of the South Scotia Ridge showed significant temporal variability in the characteristics

  6. Does Graft Particle Type and Size Affect Ridge Dimensional Changes After Alveolar Ridge Split Procedure?

    PubMed

    Kheur, Mohit G; Kheur, Supriya; Lakha, Tabrez; Jambhekar, Shantanu; Le, Bach; Jain, Vinay

    2018-04-01

    The absence of an adequate volume of bone at implant sites requires augmentation procedures before the placement of implants. The aim of the present study was to assess the ridge width gain with the use of allografts and biphasic β-tricalcium phosphate with hydroxyapatite (alloplast) in ridge split procedures, when each were used in small (0.25 to 1 mm) and large (1 to 2 mm) particle sizes. A randomized controlled trial of 23 subjects with severe atrophy of the mandible in the horizontal dimension was conducted in a private institute. The patients underwent placement of 49 dental implants after a staged ridge split procedure. The patients were randomly allocated to alloplast and allograft groups (predictor variable). In each group, the patients were randomly assigned to either small graft particle or large graft particle size (predictor variable). The gain in ridge width (outcome variable) was assessed before implant placement. A 2-way analysis of variance test and the Student unpaired t test were used for evaluation of the ridge width gain between the allograft and alloplast groups (predictor variable). Differences were considered significant if P values were < .05. The sample included 23 patients (14 men and 9 women). The patients were randomly allocated to the alloplast (n = 11) or allograft (n = 12) group before the ridge split procedure. In each group, they were assigned to a small graft particle or large graft particle size (alloplast group, small particle in 5 and large particle size in 6 patients; allograft group, small particle in 6 and large particle size in 6). A statistically significant difference was observed between the 2 graft types. The average ridge width gain was significantly greater in the alloplast group (large, 4.40 ± 0.24 mm; small, 3.52 ± 0.59 mm) than in the allograft group (large, 3.82 ± 0.19 mm; small, 2.57 ± 0.16 mm). For both graft types (alloplast and allograft), the large particle size graft resulted in a

  7. High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine

    USDA-ARS?s Scientific Manuscript database

    Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal models. Here, we examined the effects of high-fat, high-fructose corn syrup, high-cho...

  8. Compressive strain in Lunae Planum-shortening across wrinkle ridges

    NASA Technical Reports Server (NTRS)

    Plescia, J. B.

    1991-01-01

    Wrinkle ridges have long been considered to be structural or structurally controlled features. Most, but not all, recent studies have converged on a model in which wrinkle ridges are structural features formed under compressive stress; the deformation being accommodated by faulting and folding. Given that wrinkle ridges are compressive tectonic features, an analysis of the associated shortening and strain provides important quantitative information about local and regional deformation. Lunae Planum is dominated by north-south trending ridges extending from Kasei Valles in the north to Valles Marineris in the south. To quantify the morphometric character, a photoclinometric study was undertaken for ridges on Lunae Planum using the Davis and Soderblom. More than 25 ridges were examined between long. 57 and 80 deg, lat. 5 to 25 deg N. For each ridge, several profiles were obtained along its length. Ridge width, total relief, and elevation offset were measured for each ridge. Analyses are given.

  9. Ridges and scarps in the equatorial belt of Mars

    USGS Publications Warehouse

    Lucchitta, B.K.; Klockenbrink, J.L.

    1981-01-01

    The morphology and distribution of ridges and scarps on Mars in the ?? 30?? latitude belt were investigated. Two distinct types of ridges were recognized. The first is long and linear, resembling mare ridges on the Moon; it occurs mostly in plains areas. The other is composed of short, anastomosing segments and occurs mostly in ancient cratered terrain and intervening plateaus. Where ridges are eroded, landscape configurations suggest that they are located along regional structures. The age of ridges is uncertain, but some are as young as the latest documented volcanic activity on Mars. The origins of ridges are probably diverse-they may result from wrinkling due to compression or from buckling due to settling over subsurface structures. The similar morphologic expressions of ridge types of various origins may be related to a similar deformation mechanism caused by two main factors: (1) most ridges are developed in thick layers of competent material and (2) ridges formed under stresses near a free surface. ?? 1981 D. Reidel Publishing Co.

  10. Heat flow, morphology, pore fluids and hydrothermal circulation in a typical Mid-Atlantic Ridge flank near Oceanographer Fracture Zone

    NASA Astrophysics Data System (ADS)

    Le Gal, V.; Lucazeau, F.; Cannat, M.; Poort, J.; Monnin, C.; Battani, A.; Fontaine, F.; Goutorbe, B.; Rolandone, F.; Poitou, C.; Blanc-Valleron, M.-M.; Piedade, A.; Hipólito, A.

    2018-01-01

    Hydrothermal circulation affects heat and mass transfers in the oceanic lithosphere, not only at the ridge axis but also on their flanks, where the magnitude of this process has been related to sediment blanket and seamounts density. This was documented in several areas of the Pacific Ocean by heat flow measurements and pore water analysis. However, as the morphology of Atlantic and Indian ridge flanks is generally rougher than in the Pacific, these regions of slow and ultra-slow accretion may be affected by hydrothermal processes of different regimes. We carried out a survey of two regions on the eastern and western flanks of the Mid-Atlantic Ridge between Oceanographer and Hayes fracture zones. Two hundred and eight new heat flow measurements were obtained along six seismic profiles, on 5 to 14 Ma old seafloor. Thirty sediment cores (from which porewaters have been extracted) have been collected with a Kullenberg corer equipped with thermistors thus allowing simultaneous heat flow measurement. Most heat flow values are lower than those predicted by purely conductive cooling models, with some local variations and exceptions: heat flow values on the eastern flank of the study area are more variable than on the western flank, where they tend to increase westward as the sedimentary cover in the basins becomes thicker and more continuous. Heat flow is also higher, on average, on the northern sides of both the western and eastern field regions and includes values close to conductive predictions near the Oceanographer Fracture Zone. All the sediment porewaters have a chemical composition similar to that of bottom seawater (no anomaly linked to fluid circulation has been detected). Heat flow values and pore fluid compositions are consistent with fluid circulation in volcanic rocks below the sediment. The short distances between seamounts and short fluid pathways explain that fluids flowing in the basaltic aquifer below the sediment have remained cool and unaltered

  11. 36 CFR 7.34 - Blue Ridge Parkway.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Blue Ridge Parkway. 7.34... REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.34 Blue Ridge Parkway. (a) Snowmobiles. After consideration... waters of the Blue Ridge Parkway is prohibited except on the waters of Price Lake. (2) Vessels using...

  12. 36 CFR 7.34 - Blue Ridge Parkway.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Blue Ridge Parkway. 7.34... REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.34 Blue Ridge Parkway. (a) Snowmobiles. After consideration... waters of the Blue Ridge Parkway is prohibited except on the waters of Price Lake. (2) Vessels using...

  13. 36 CFR 7.34 - Blue Ridge Parkway.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Blue Ridge Parkway. 7.34... REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.34 Blue Ridge Parkway. (a) Snowmobiles. After consideration... waters of the Blue Ridge Parkway is prohibited except on the waters of Price Lake. (2) Vessels using...

  14. Spontaneous Time Symmetry Breaking in System with Mixed Strategy Nash Equilibrium: Evidences in Experimental Economics Data

    NASA Astrophysics Data System (ADS)

    Wang, Zhijian; Xu, Bin; Zhejiang Collaboration

    2011-03-01

    In social science, laboratory experiment with human subjects' interaction is a standard test-bed for studying social processes in micro level. Usually, as in physics, the processes near equilibrium are suggested as stochastic processes with time-reversal symmetry (TRS). To the best of our knowledge, near equilibrium, the breaking time symmetry, as well as the existence of robust time anti-symmetry processes, has not been reported clearly in experimental economics till now. By employing Markov transition method to analysis the data from human subject 2x2 Games with wide parameters and mixed Nash equilibrium, we study the time symmetry of the social interaction process near Nash equilibrium. We find that, the time symmetry is broken, and there exists a robust time anti-symmetry processes. We also report the weight of the time anti-symmetry processes in the total processes of each the games. Evidences in laboratory marketing experiments, at the same time, are provided as one-dimension cases. In these cases, time anti-symmetry cycles can also be captured. The proposition of time anti-symmetry processes is small, but the cycles are distinguishable.

  15. Volcanism and hydrothermalism on a hotspot-influenced ridge: Comparing Reykjanes Peninsula and Reykjanes Ridge, Iceland

    NASA Astrophysics Data System (ADS)

    Pałgan, Dominik; Devey, Colin W.; Yeo, Isobel A.

    2017-12-01

    Current estimates indicate that the number of high-temperature vents (one of the primary pathways for the heat extraction from the Earth's mantle) - at least 1 per 100 km of axial length - scales with spreading rate and should scale with crustal thickness. But up to present, shallow ridge axes underlain by thick crust show anomalously low incidences of high-temperature activity. Here we compare the Reykjanes Ridge, an abnormally shallow ridge with thick crust and only one high-temperature vent known over 900 km axial length, to the adjacent subaerial Reykjanes Peninsula (RP), which is characterized by high-temperature geothermal sites confined to four volcanic systems transected by fissure swarms with young (Holocene) volcanic activity, multiple faults, cracks and fissures, and continuous seismic activity. New high-resolution bathymetry (gridded at 60 m) of the Reykjanes Ridge between 62°30‧N and 63°30‧N shows seven Axial Volcanic Ridges (AVR) that, based on their morphology, geometry and tectonic regime, are analogues for the volcanic systems and fissure swarms on land. We investigate in detail the volcano-tectonic features of all mapped AVRs and show that they do not fit with the previously suggested 4-stage evolution model for AVR construction. Instead, we suggest that AVR morphology reflects the robust or weak melt supply to the system and two (or more) eruption mechanisms may co-exist on one AVR (in contrast to 4-stage evolution model). Our interpretations indicate that, unlike on the Reykjanes Peninsula, faults on and around AVRs do not cluster in orientation domains but all are subparallel to the overall strike of AVRs (orthogonal to spreading direction). High abundance of seamounts shows that the region centered at 62°47‧N and 25°04‧W (between AVR-5 and -6) is volcanically robust while the highest fault density implies that AVR-1 and southern part of AVR-6 rather undergo period of melt starvation. Based on our observations and interpretations we

  16. Southeast Indian Ridge Between the Rodriguez Triple Junction and the Amsterdam and Saint-Paul Islands: Detailed Kinematics for the Past 20 m.y.

    NASA Astrophysics Data System (ADS)

    Royer, Jean-Yves; Schlich, Roland

    1988-11-01

    The Southeast Indian Ridge has the fastest spreading rates of the three mid-oceanic ridge systems of the Indian Ocean and has recorded the movements of Antarctica relative to Australia and India since the Late Cretaceous. New bathymetric and magnetic data have been collected by the R/V Marion Dufresne (1983) and the R/V Jean Charcot (1984), on the western part of this ridge, between the Rodriguez Triple Junction (25.5°S, 70.0°E) and the Amsterdam and Saint-Paul islands (38°S, 78°E). These data bring additional information on the seafloor magnetic pattern produced by the Southeast Indian Ridge during the past 20 m.y. A new tectonic chart is proposed for the area around the Amsterdam and Saint-Paul islands. We have mapped 17 isochrons ranging from anomalies 6 to 1 (20.5-0.7 Ma) based on the compilation of all the data available in this area (25 cruises). Their distribution clearly shows asymmetric features. Reconstructions at short time intervals show that stage poles of rotation describe oscillatory movements along a direction parallel to the Southeast Indian Ridge axis. Observed changes in spreading rates and the stability of the spreading directions since the Miocene support this result.

  17. Evidence for large-scale submarine mass wasting associated with growth of oceanic core complexes, 16°N, Mid-Atlantic Ridge.

    NASA Astrophysics Data System (ADS)

    Urann, B.; Cheadle, M. J.; John, B. E.; Dick, H. J.

    2016-12-01

    Slow spreading ridges display distinct geomorphologic features, often interpreted as long-lived detachment faults, where mafic and ultramafic rocks are exposed at the seafloor. Many bathymetric features in these regions are viewed as the result of tectonic processes (long lived detachment faults), however other features are clearly the result of mass wasting. Here we report zircon U-Pb dates from four gabbro and Fe-Ti oxide gabbro dredge samples recovered from the North Segment on the western flank of the mid-Atlantic ridge (MAR) at 16°N. Initial SIMS U-Pb zircon dating using the Stanford-USGS SHRIMP-RG ion-microprobe yield 230 Th-corrected zircon 206Pb/238U dates within error of one another. The two westernmost samples are separated by 14km along strike, and come from dredges on the footwall of a high-angle normal fault. They have dates of 1.112 +/-0.083 Ma and 1.181 +/- 0.074Ma, and both lie 12-13km west of the present day axial volcanic ridge, These samples therefore yield a spreading rate of 12km/Ma, as expected for this part of the MAR. The two eastern samples lie up to 4.5 km east of the western samples and yield dates of 1.14_/-0.55Ma and 1,221+/-0.027Ma, indistinguishable from those of the samples to the west. Given the predicted spreading rate of 12 km/Ma, these samples should be 0.375Ma younger than those to the west, and should yield dates of 0.74Ma. To account for the similarity in age, we suggest that mass wasting and large landslides from the high angle fault scarps displaced as much as 40km3 of material into the axial valley, dispersing gabbro of similar age over a wide area. This interpretation is consistent with the available multi-beam bathymetry that can be explained in terms of large landslides flowing from the bounding fault scarps into the axial valley towards the present day axial volcanic ridge. If correct, this interpretation has significant implications for evaluating potential tsunami hazards at mid-ocean ridges.

  18. Ridges on Europa

    NASA Image and Video Library

    1997-12-18

    This view of Jupiter's moon Europa shows a portion of the surface that has been highly disrupted by fractures and ridges. This picture covers an area about 238 kilometers (150 miles) wide by 225 kilometers (140 miles), or about the distance between Los Angeles and San Diego. Symmetric ridges in the dark bands suggest that the surface crust was separated and filled with darker material, somewhat analogous to spreading centers in the ocean basins of Earth. Although some impact craters are visible, their general absence indicates a youthful surface. The youngest ridges, such as the two features that cross the center of the picture, have central fractures, aligned knobs, and irregular dark patches. These and other features could indicate cryovolcanism, or processes related to eruption of ice and gases. This picture, centered at 16 degrees south latitude, 196 degrees west longitude, was taken at a distance of 40,973 kilometers (25,290 mi) on November 6, 1996 by the Galileo spacecraft solid state imaging television camera onboard the Galileo spacecraft during its third orbit around Jupiter. http://photojournal.jpl.nasa.gov/catalog/PIA00518

  19. Quantitative imaging of fibrotic and morphological changes in liver of non-alcoholic steatohepatitis (NASH) model mice by second harmonic generation (SHG) and auto-fluorescence (AF) imaging using two-photon excitation microscopy (TPEM).

    PubMed

    Yamamoto, Shin; Oshima, Yusuke; Saitou, Takashi; Watanabe, Takao; Miyake, Teruki; Yoshida, Osamu; Tokumoto, Yoshio; Abe, Masanori; Matsuura, Bunzo; Hiasa, Yoichi; Imamura, Takeshi

    2016-12-01

    Non-alcoholic steatohepatitis (NASH) is a common liver disorder caused by fatty liver. Because NASH is associated with fibrotic and morphological changes in liver tissue, a direct imaging technique is required for accurate staging of liver tissue. For this purpose, in this study we took advantage of two label-free optical imaging techniques, second harmonic generation (SHG) and auto-fluorescence (AF), using two-photon excitation microscopy (TPEM). Three-dimensional ex vivo imaging of tissues from NASH model mice, followed by image processing, revealed that SHG and AF are sufficient to quantitatively characterize the hepatic capsule at an early stage and parenchymal morphologies associated with liver disease progression, respectively.

  20. A 600-ka Arctic sea-ice record from Mendeleev Ridge based on ostracodes

    USGS Publications Warehouse

    Cronin, Thomas M.; Polyak, L.V.; Reed, D.; Kandiano, E. S.; Marzen, R. E.; Council, E. A.

    2013-01-01

    Arctic paleoceanography and sea-ice history were reconstructed from epipelagic and benthic ostracodes from a sediment core (HLY0503-06JPC, 800 m water depth) located on the Mendeleev Ridge, Western Arctic Ocean. The calcareous microfaunal record (ostracodes and foraminifers) covers several glacial/interglacial cycles back to estimated Marine Isotope Stage 13 (MIS 13, ∼500 ka) with an average sedimentation rate of ∼0.5 cm/ka for most of the stratigraphy (MIS 5–13). Results based on ostracode assemblages and an unusual planktic foraminiferal assemblage in MIS 11 dominated by a temperate-water species Turborotalita egelida show that extreme interglacial warmth, high surface ocean productivity, and possibly open ocean convection characterized MIS 11 and MIS 13 (∼400 and 500 ka, respectively). A major shift in western Arctic Ocean environments toward perennial sea ice occurred after MIS 11 based on the distribution of an ice-dwelling ostracode Acetabulastoma arcticum. Spectral analyses of the ostracode assemblages indicate sea ice and mid-depth ocean circulation in western Arctic Ocean varied primarily at precessional (∼22 ka) and obliquity (∼40 ka) frequencies.

  1. Petrological systematics of mid-ocean ridge basalts: Constraints on melt generation beneath ocean ridges

    NASA Astrophysics Data System (ADS)

    Langmuir, Charles H.; Klein, Emily M.; Plank, Terry

    Mid-ocean ridge basalts (MORB) are a consequence of pressure-release melting beneath ocean ridges, and contain much information concerning melt formation, melt migration and heterogeneity within the upper mantle. MORB major element chemical systematics can be divided into global and local aspects, once they have been corrected for low pressure fractionation and interlaboratory biases. Regional average compositions for ridges unaffected by hot spots ("normal" ridges) can be used to define the global correlations among normalized Na2O, FeO, TiO2 and SiO2 contents, CaO/Al2O3 ratios, axial depth and crustal thickness. Back-arc basins show similar correlations, but are offset to lower FeO and TiO2 contents. Some hot spots, such as the Azores and Galapagos, disrupt the systematics of nearby ridges and have the opposite relationships between FeO, Na2O and depth over distances of 1000 km. Local variations in basalt chemistry from slow- and fast-spreading ridges are distinct from one another. On slow-spreading ridges, correlations among the elements cross the global vector of variability at a high angle. On the fast-spreading East Pacific Rise (EPR), correlations among the elements are distinct from both global and slow-spreading compositional vectors, and involve two components of variation. Spreading rate does not control the global correlations, but influences the standard deviations of axial depth, crustal thickness, and MgO contents of basalts. Global correlations are not found in very incompatible trace elements, even for samples far from hot spots. Moderately compatible trace elements for normal ridges, however, correlate with the major elements. Trace element systematics are significantly different for the EPR and the mid-Atlantic Ridge (MAR). Normal portions of the MAR are very depleted in REE, with little variability; hot spots cause large long wavelength variations in REE abundances. Normal EPR basalts are significantly more enriched than MAR basalts from normal

  2. How Fast Do Europa's Ridges Grow?

    NASA Astrophysics Data System (ADS)

    Melosh, H. J.; Turtle, E. P.; Freed, A. M.

    2017-11-01

    We demonstrate with our incremental wedging model of ridge formation that ridges must grow in 5000 years or less to prevent their material flowing down an underlying warm ice channel. This conclusion holds for other models as well.

  3. Mantle plume capture, anchoring and outflow during ridge interaction

    NASA Astrophysics Data System (ADS)

    Gibson, S. A.; Richards, M. A.; Geist, D.

    2015-12-01

    Geochemical and geophysical studies have shown that >40% of the world's mantle plumes are currently interacting with the global ridge system and such interactions may continue for up to 180 Myr[1]. At sites of plume-ridge interaction up to 1400 km of the spreading centre is influenced by dispersed plume material but there are few constraints on how and where the ridge-ward transfer of deep-sourced material occurs, and also how it is sustained over long time intervals. Galápagos is an archetypal example of an off-axis plume and sheds important light on these mechanisms. The Galápagos plume stem is located ~200 km south of the spreading axis and its head influences 1000 km of the ridge. Nevertheless, the site of enriched basalts, greatest crustal thickness and elevated topography on the ridge, together with active volcanism in the archipelago, correlate with a narrow zone (~150 km) of low-velocity, high-temperature mantle that connects the plume stem and ridge at depths of ~100 km[2]. The enriched ridge basalts contain a greater amount of partially-dehydrated, recycled oceanic crust than basalts elsewhere on the spreading axis, or indeed basalts erupted in the region between the plume stem and ridge. The presence of these relatively volatile-rich ridge basalts requires flow of plume material below the peridotite solidus (i.e.>80 km). We propose a 2-stage model for the development and sustainment of a confined zone of deep ridge-ward plume flow. This involves initial on-axis capture and establishment of a sub-ridge channel of plume flow. Subsequent anchoring of the plume stem to a contact point on the ridge during axis migration results in confined ridge-ward flow of plume material via a deep network of melt channels embedded in the normal spreading and advection of the plume head[2]. Importantly, sub-ridge flow is maintained. The physical parameters and styles of mantle flow we have defined for Galápagos are less-well known at other sites of plume-ridge

  4. Rare earth abundances and Rb-Sr systematics of basalts, gabbro, anorthosite and minor granitic rocks from the Indian Ocean Ridge System, Western Indian Ocean

    USGS Publications Warehouse

    Hedge, C.E.; Futa, K.; Engel, C.G.; Fisher, R.L.

    1979-01-01

    Basalts dredged from the Mid-Indian Ocean Ridge System have rare earth, Rb, and Sr concentrations like those from other mid-ocean ridges, but have slightly higher Sr87/Sr86 ratios. Underlying gabbroic complexes are similar to the basalts in Sr87/Sr86, but are poorer K, Rb, and in rare earths. The chemical and isotopic data, as well as the geologic relations suggest a cumulate origin for the bulk of the gabbroic complexes. ?? 1979 Springer-Verlag.

  5. Stress history and geotechnical properties of sediment from the Cape Fear Diapir, Blake Ridge Diapir, and Blake Ridge

    USGS Publications Warehouse

    Winters, W.J.

    2000-01-01

    Geotechnical properties of sediment from Ocean Drilling Program Leg 164 are presented as: (1) normalized shipboard strength ratios from the Cape Fear Diapir, the Blake Ridge Diapir, and the Blake Ridge; and (2) Atterberg limit, vane shear strength, pocket-penetrometer strength, and constant-rate-of-strain consolidation results from Hole 995A, located on the Blake Ridge. This study was conducted to understand the stress history in a region characterized by high sedimentation rates and the presence of gas hydrates. Collectively, the results indicate that sediment from the Blake Ridge exhibits significant underconsolidated behavior, except near the seafloor. At least 10 m of additional overburden was removed by erosion or mass wasting at Hole 993A on the Cape Fear Diapir, compared to nearby sites.

  6. Wrinkle Ridges and Young Fresh Crater

    NASA Image and Video Library

    2002-06-04

    This NASA Mars Odyssey image is of the ridged plains of Lunae Planum in the northern hemisphere of Mars. Wrinkle ridges, a very common landform on Mars, Mercury, Venus, and the Moon, are found mostly along the eastern side of the image.

  7. Recent coastal evolution in a carbonate sandy environments and relation to beach ridge formation: the case of Anegada, British Virgin Islands

    NASA Astrophysics Data System (ADS)

    Cescon, Anna Lisa; Cooper, J. Andrew G.; Jackson, Derek W. T.

    2014-05-01

    In a changing climate context coastal areas will be affected by more frequent extreme events. Understanding the relationship between extreme events and coastal geomorphic response is critical to future adaptation plans. Beach ridge landforms commonly identified as hurricane deposits along tropical coasts in Australia and in the Caribbean Sea. However their formative processes in such environments are still not well understood. In particular, the role of different extreme wave events (storm waves, tsunami waves and extreme swell), in generating beach ridges is critical to their use as palaeotempestology archives. Anegada Island is a carbonate platform situated in the British Virgin Island between the Atlantic Ocean and the Caribbean Sea. Pleistocene in age, Anegada is surrounded by the Horseshoe fringing coral reef. Two Holocene sandy beach ridge plains are present on the western part of the island. The north beach ridge plain is Atlantic facing and has at least 30 ridges; the south beach ridge plain is Caribbean Sea facing and contains 10 ridges. Historical aerial photos enabled the shoreline evolution from 1953 to 2012 to be studied. Three different coastal domains are associate with the beach ridge plains: strong east-west longshore transport affects the north coastline, the south-west coastline from West End to Pomato Point represents an export corridor for these sediments and finally, along the southern coastline, from Pomato Point to Settling Point the area presents a depositional zone with little to no change in the last 70 years. The link between the extreme wave events that have affected Anegada Island in the last 70 years and beach ridge creation is discussed. Hurricane Donna crossed over Anegada Island in 1960: its geomorphological signature is tracked in the shoreline change analysis and its implication in beach ridge formation is discussed. Anegada Island has also been impacted by tsunami waves (Atwater et al., 2012) and a comparative discussion of the

  8. Observations of sea ice ridging in the Weddell Sea

    NASA Astrophysics Data System (ADS)

    Granberg, Hardy B.; Leppaäranta, Matti

    1999-11-01

    Sea ice surface topography data were obtained by helicopter-borne laser profiling during the First Finnish Antarctic Expedition (FINNARP-89). The measurements were made near the ice margin at about 73°S, 27°W in the eastern Weddell Sea on December 31, 1989, and January 1, 1990. Five transects, ranging in length from 127 to 163 km and covering a total length of 724 km, are analyzed. With a lower cutoff of 0.91 m the overall ridge frequency was 8.4 ridges/km and the average ridge height was 1.32 m. The spatial variations in ridging were large; for 36 individual 20-km segments the frequencies were 2-16 ridges/km and the mean heights were 1.16-1.56 m. The frequencies and mean heights were weakly correlated. The distributions of the ridge heights followed the exponential distribution; the spacings did not pass tests for either the exponential or the lognormal distribution, but the latter was much closer. In the 20-km segments the areally averaged thickness of ridged ice was 0.51±0.28 m, ranging from 0.10 to 1.15 m. The observed ridge size and frequency are greater than those known for the Ross Sea. Compared with the central Arctic, the Weddell Sea ridging frequencies are similar but the ridge heights are smaller, possibly as a result of differences in snow accumulation.

  9. Improved Digitization of Lunar Mare Ridges with LROC Derived Products

    NASA Astrophysics Data System (ADS)

    Crowell, J. M.; Robinson, M. S.; Watters, T. R.; Bowman-Cisneros, E.; Enns, A. C.; Lawrence, S.

    2011-12-01

    Lunar wrinkle ridges (mare ridges) are positive-relief structures formed from compressional stress in basin-filling flood basalt deposits [1]. Previous workers have measured wrinkle ridge orientations and lengths to investigate their spatial distribution and infer basin-localized stress fields [2,3]. Although these plots include the most prominent mare ridges and their general trends, they may not have fully captured all of the ridges, particularly the smaller-scale ridges. Using Lunar Reconnaissance Orbiter Wide Angle Camera (WAC) global mosaics and derived topography (100m pixel scale) [4], we systematically remapped wrinkle ridges in Mare Serenitatis. By comparing two WAC mosaics with different lighting geometry, and shaded relief maps made from a WAC digital elevation model (DEM) [5], we observed that some ridge segments and some smaller ridges are not visible in previous structure maps [2,3]. In the past, mapping efforts were limited by a fixed Sun direction [6,7]. For systematic mapping we created three shaded relief maps from the WAC DEM with solar azimuth angles of 0°, 45°, and 90°, and a fourth map was created by combining the three shaded reliefs into one, using a simple averaging scheme. Along with the original WAC mosaic and the WAC DEM, these four datasets were imported into ArcGIS, and the mare ridges of Imbrium, Serenitatis, and Tranquillitatis were digitized from each of the six maps. Since the mare ridges are often divided into many ridge segments [8], each major component was digitized separately, as opposed to the ridge as a whole. This strategy enhanced our ability to analyze the lengths, orientations, and abundances of these ridges. After the initial mapping was completed, the six products were viewed together to identify and resolve discrepancies in order to produce a final wrinkle ridge map. Comparing this new mare ridge map with past lunar tectonic maps, we found that many mare ridges were not recorded in the previous works. It was noted

  10. Europa Ridges, Hills and Domes

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This moderate-resolution view of the surface of one of Jupiter's moons, Europa, shows the complex icy crust that has been extensively modified by fracturing and the formation of ridges. The ridge systems superficially resemble highway networks with overpasses, interchanges and junctions. From the relative position of the overlaps, it is possible to determine the age sequence for the ridge sets. For example, while the 8-kilometer-wide (5-mile) ridge set in the lower left corner is younger than most of the terrain seen in this picture, a narrow band cuts across the set toward the bottom of the picture, indicating that the band formed later. In turn, this band is cut by the narrow 2- kilometer-wide (1.2-mile) double ridge running from the lower right to upper left corner of the picture. Also visible are numerous clusters of hills and low domes as large as 9 kilometers (5.5 miles) across, many with associated dark patches of non-ice material. The ridges, hills and domes are considered to be ice-rich material derived from the subsurface. These are some of the youngest features seen on the surface of Europa and could represent geologically young eruptions.

    This area covers about 140 kilometers by 130 kilometers (87 miles by 81 miles) and is centered at 12.3 degrees north latitude, 268 degrees west longitude. Illumination is from the east (right side of picture). The resolution is about 180 meters (200 yards) per pixel, meaning that the smallest feature visible is about a city block in size. The picture was taken by the Solid State Imaging system on board the Galileo spacecraft on February 20, 1997, from a distance of 17,700 kilometers (11,000 miles) during its sixth orbit around Jupiter.

    The Jet Propulsion Laboratory, Pasadena, CA, manages the mission for NASA's Office of Space Science, Washington D.C. This image and other images and data received from Galileo are posted on the World Wide Web Galileo mission home page at http://galileo.jpl.nasa.gov.

  11. Ridge and Talus in Lycus Sulci

    NASA Image and Video Library

    2015-08-12

    This image from NASA Mars Reconnaissance Orbiter spacecraft nicely captures several influential geologic processes that have shaped the landscape of Lycus Sulci. Our observation covers an area of about 7.5 by 5.4 kilometers in Lycus Sulci, located just to the northwest of Olympus Mons in the Tharsis region of Mars. "Sulci" is a Latin term meaning "furrow" or "groove." In this case, Lycus Sulci is a region comprised of a series of depressions and ridges. Like most of the Tharsis region, Lycus Sulci exhibits thick deposits of light-toned Martian dust; the slopes on ridges in this region feature abundant streaks. These streaks are long, thin dark-toned features. They appear when the superficial light-tone fine-grained materials (i.e., Martian dust) suddenly move down slope and expose the darker underlying volcanic surfaces. Repeat imaging shows that dust streaks are consistently dark when they are initially formed and become lighter over time. This is due to the steady deposition of dust from the atmosphere. Slope streaks are also visible along the slopes of ridges and shallow depressions. Two ridges here exhibit partially exposed bedrock. These outcrops are interpreted to still have abundant coatings and dust, obscuring the underlying bedrock. This interpretation is based on the lack of bluish color for volcanic bedrock from the infrared-red-blue swath of our camera, and consistent with the homogenous tannish color we see throughout the same swath. It's possible that the ridges here and throughout the Lycus Sulci region formed via volcanic and tectonic processes, which have been further sculpted by wind erosion and other mass wasting processes. For example, talus slopes, which appear as fine-grained fans or conical-shaped deposits, originate from the steepest portions of the ridges. These form when the rocks or deposits on the steepest slopes of a ridge fail under the influence of Martian gravity and their own mass, causing an avalanche of these materials, which then

  12. Lithospheric Flexural Modeling of Iapetus' Equatorial Ridge

    NASA Astrophysics Data System (ADS)

    Zheng, W.; Ip, W.-H.; Teng, L. S.

    2012-04-01

    Iapetus, which is one of Saturn's ball-shaped satellites, has some unique features in the Solar System. This satellite has a mean radius of 735 km, and there is an approximately 20-kilometer-high mountain lying precisely on its equator. The mountain is known as an "equatorial ridge" since it makes Iapetus appear walnut shaped. The origin of the equatorial ridge is attributed to several hypotheses, including different endogenesis and exogenesis processes. In this work, we attempted to construct a flexural model of the equatorial ridge using elastic lithosphere theory. The equatorial ridge is treated as a linear load which exerts uniform force on Iapetus' hard shell (i.e. elastic lithosphere of Iapetus). To calculate the deflection of surface, we use the Digital Terrain Model (DTM) data of Iapetus' leading side published by Giese et al. (2008). Giese et al. also pointed out that the elastic lithospheric thickness of Iapetus must exceed 100 km to support the ridge without deflecting. However, we found possible evidence in the DTM data that implied deflection. There are two sites of surface depression on the northern side of the equatorial ridge. The few-kilometer deflection implies a thinner lithosphere than previous suggested. Assume that the thickness of elastic lithosphere is only 5% below of the radius of Iapetus, so the flat-Earth and one-plate condition could adapt to the flexure model of Iapetus. Based on analysis of the distance between a bulge and the ridge, the calculated lithospheric thickness is 6-10 km. The new result seems controversial, but the modeled surface profile is highly consistent with numerical ridge DTM profile extracted from Giese et al. (2008). Thinner lithosphere also supports the contraction model proposed by Sandwell and Schubert (2010) since the bucking harmonic degree increases. In the other hand, the transformation layer between hard shell and plastic inner core may need constraint on thermal history or crystal form of ice. In

  13. P-T-t paths from polyphased garnets of the Yenisey Ridge: evidence for three tectonothermal events along the western margin of Siberian craton

    NASA Astrophysics Data System (ADS)

    Likhanov, Igor

    2015-04-01

    Studies of pelitic gneisses and schists within the Yenisey regional shear zone (Garevka complex) at the western margin of the Siberian craton provide important constraints on the tectonothermal events and geodynamic processes in the Yenisey Ridge. In situ U-Th-Pb geochronology of monazite and xenotime from different growth zones of the garnet porphyroblasts coupled with P-T path calculations derived from garnet zoning patterns records three superimposed metamorphic event [1]. The different field gradients reflect contrasting tectonic settings. The first stage occurred as a result of the Grenville-age orogeny during late Meso-early Neoproterozoic (1050-850 Ma) and was marked by low-pressure zoned metamorphism at c. 4.8-5.0 kbar and 565-580 °C with a metamorphic field gradient of dT/dZ = 20-30 °C/km. At the second stage, the rocks experienced middle Neoproterozoic (801-793 Ma) collision-related medium-pressure metamorphism at c. 7.7-7.9 kbar and 630 °C with dT/dZ < 10 °C/km. The final stage evolved as a synexhumation retrograde metamorphism (785-776 Ma) at c. 4.8-5.4 kbar and 500 °C with dT/dZ < 14 °C/km and recorded uplift of the rocks to upper crustal levels in shear zones. The duration of post-collisional thrust exhumation does not exceed 16 Myr, which gives an exhumation rate of the metamorphic rocks of about 500-700 m/Myr [2]. This is in good agreement with the rate of exhumation (400 m/Myr) calculated for coeval collision-related metamorphic events in the Teya complex of the Yenisey Ridge [3] resulted from crustal thickening due to overthrusting [4] and also agrees with the results of thermomechanical numerical modeling (350 m/Myr) [5]. The final stages of collisional orogeny were followed by the development of rift-related bimodal dyke swarms of the Baikal-Yenisey belt, resulting from Neoproterozoic (790-780 Ma) extensional processes along the western margin of the Siberian craton and the onset of Rodinia's breakup [6]. Post-Grenville metamorphic

  14. Strong signatures of high-latitude blocks and subtropical ridges in winter PM10 over Europe

    NASA Astrophysics Data System (ADS)

    Garrido-Perez, Jose M.; Ordóñez, Carlos; García-Herrera, Ricardo

    2017-10-01

    This paper analyses the impact of high-latitude blocks and subtropical ridges on daily PM10 (particulate matter ≤ 10 μm) observations obtained from the European Environment Agency's air quality database (AirBase) for the winter period of 2000-2010. The response of the pollutant concentrations to the location of blocks and ridges with centres in two main longitudinal sectors (Atlantic, ATL, 30°-0° W; European, EUR, 0°-30° E) is examined. In particular, EUR blocking is associated with a collapse of the boundary layer as well as reduced wind speeds and precipitation occurrence, yielding large positive anomalies which average 12 μg m-3 over the whole continent. Conversely, the enhanced zonal flow around 50°-60° N and the increased occurrence of precipitation over northern-central Europe on days with ATL ridges favour the ventilation of the boundary layer and the impact of washout processes, reducing PM10 concentrations on average by around 8 μg m-3. The presence of EUR blocks is also concurrent with an increased probability of exceeding the air quality target (50 μg m-3 for 24-h averaged PM10) and the local 90th percentiles for this pollutant at many sites in central Europe, while the opposite effect is found for ridges. In addition, the effect of synoptic persistence on the PM10 concentrations is stronger for EUR blocks than for ATL ridges. This could benefit the predictability of PM10 extremes over wide areas of the region. Finally, we have found that the combined or isolated effect of both synoptic patterns can partly control the interannual variability of winter mean PM10 at many sites of north-western and central Europe, with coefficients of determination (R2) exceeding 0.80 for southern Germany. These results indicate that the response of the particulate matter (PM) concentrations to large-scale circulation patterns is stronger than previously reported for Europe and other mid-latitude regions.

  15. Mixed-strategy Nash equilibrium for a discontinuous symmetric N-player game

    NASA Astrophysics Data System (ADS)

    Hilhorst, H. J.; Appert-Rolland, C.

    2018-03-01

    We consider a game in which each player must find a compromise between more daring strategies that carry a high risk for him to be eliminated, and more cautious ones that, however, reduce his final score. For two symmetric players this game was originally formulated in 1961 by Dresher, who modeled a duel between two opponents. The game has also been of interest in the description of athletic competitions. We extend here the two-player game to an arbitrary number N of symmetric players. We show that there is a mixed-strategy Nash equilibrium and find its exact analytic expression, which we analyze in particular in the limit of large N, where mean-field behavior occurs. The original game with N  =  2 arises as a singular limit of the general case.

  16. Characteristics of Hydrothermal Mineralization in Ultraslow Spreading Ridges

    NASA Astrophysics Data System (ADS)

    Zhou, H.; Yang, Q.; Ji, F.; Dick, H. J.

    2014-12-01

    Hydrothermal activity is a major component of the processes that shape the composition and structure of the ocean crust, providing a major pathway for the exchange of heat and elements between the Earth's crust and oceans, and a locus for intense biological activity on the seafloor and underlying crust. In other hand, the structure and composition of hydrothermal systems are the result of complex interactions between heat sources, fluids, wall rocks, tectonic controls and even biological processes. Ultraslow spreading ridges, including the Southwest Indian Ridge, the Gakkel Ridge, are most remarkable end member in plate-boundary structures (Dick et al., 2003), featured with extensive tectonic amagmatic spreading and frequent exposure of peridotite and gabbro. With intensive surveys in last decades, it is suggested that ultraslow ridges are several times more effective than faster-spreading ridges in sustaining hydrothermal activities. This increased efficiency could attributed to deep mining of heat and even exothermic serpentinisation (Baker et al., 2004). Distinct from in faster spreading ridges, one characteristics of hydrothermal mineralization on seafloor in ultraslow spreading ridges, including the active Dragon Flag hydrothermal field at 49.6 degree of the Southwest Indian Ridge, is abundant and pervasive distribution of lower temperature precipitated minerals ( such as Fe-silica or silica, Mn (Fe) oxides, sepiolite, pyrite, marcasite etc. ) in hydrothermal fields. Structures formed by lower temperature activities in active and dead hydrothermal fields are also obviously. High temperature precipitated minerals such as chalcopyrite etc. are rare or very limited in hydrothermal chimneys. Distribution of diverse low temperature hydrothermal activities is consistence with the deep heating mechanisms and hydrothermal circulations in the complex background of ultraslow spreading tectonics. Meanwhile, deeper and larger mineralization at certain locations along the

  17. Glacial modulation of mid-ocean ridge magmatism and anomalous Pacific Antarctic Ridge volcanism during Termination II

    NASA Astrophysics Data System (ADS)

    Asimow, P. D.; Lewis, M.; Lund, D. C.; Seeley, E.; McCart, S.; Mudahy, A.

    2017-12-01

    Glacially-driven sea level rise and fall may modulate submarine volcanism by superposing pressure changes on the tectonic decompression that causes melt production in the mantle below mid-ocean ridges. A number of recent studies have considered whether this effect is recorded in the periodicity of ridge flank bathymetry (Tolstoy, 2015; Crowley et al., 2015) but interpretation of the bathymetric data remains controversial (Goff, 2016; Olive et al., 2016). We have pursued an independent approach using hydrothermal metals in well-dated near-ridge sediment cores. Along the full length of the East Pacific Rise, in areas of the ocean with widely variable biologic productivity, there are large and consistent rises in Fe, Mn, and As concentrations during the last two glacial terminations. We interpret these cores as records of excess hydrothermal flux due to delayed delivery to the axis of excess melt generated by the preceding falls in sea level. Here we discuss the potentially related discovery, in a core near the Pacific Antarctic Ridge (PAR), of a 10 cm thick layer of basaltic ash shards up to 250 mm in size, coincident with the penultimate deglaciation (Termination II). Although the site was 8 km off-axis at the time, the glasses have major element, volatile, and trace element composition consistent with more evolved members of the axial MORB suite from the nearby ridge axis. Their morphologies are typical of pyroclastic deposits created by explosive submarine volcanism (Clague et al., 2009). We propose that a period of low magmatic flux following a sea-level rise caused cooling of crustal magmatic systems, more advanced fractionation in the axial magma chamber, and increases in viscosity and volatile concentration. We hypothesize subsequent arrival of high magmatic flux during Termination II then reactivated the system and triggered an unusually vigorous series of explosive eruptions along this segment of the PAR. Ash layers recording large eruptions such as this one

  18. Ridge Orientations of the Ridge-Forming Unit, Sinus Meridiani, Mars-A Fluvial Explanation

    NASA Technical Reports Server (NTRS)

    Wilkinson, M. Justin; Herridge, A.

    2013-01-01

    Imagery and MOLA data were used in an analysis of the ridge-forming rock unit (RFU) exposed in Sinus Meridiani (SM). This unit shows parallels at different scales with fluvial sedimentary bodies. We propose the terrestrial megafan as the prime analog for the RFU, and likely for other members of the layered units. Megafans are partial cones of fluvial sediment, with radii up to hundreds of km. Although recent reviews of hypotheses for the RFU units exclude fluvial hypotheses [1], inverted ridges in the deserts of Oman have been suggested as putative analogs for some ridges [2], apparently without appreciating The wider context in which these ridges have formed is a series of megafans [3], a relatively unappreciated geomorphic feature. It has been argued that these units conform to the megafan model at the regional, subregional and local scales [4]. At the regional scale suites of terrestrial megafans are known to cover large areas at the foot of uplands on all continents - a close parallel with the setting of the Meridiani sediments at the foot of the southern uplands of Mars, with its incised fluvial systems leading down the regional NW slope [2, 3] towards the sedimentary units. At the subregional scale the layering and internal discontinuities of the Meridiani rocks are consistent, inter alia, with stacked fluvial units [4]. Although poorly recognized as such, the prime geomorphic environment in which stream channel networks cover large areas, without intervening hillslopes, is the megafan [see e.g. 4]. Single megafans can reach 200,000 km2 [5]. Megafans thus supply an analog for areas where channel-like ridges (as a palimpsest of a prior landscape) cover the intercrater plains of Meridiani [6]. At the local, or river-reach scale, the numerous sinuous features of the RFU are suggestive of fluvial channels. Cross-cutting relationships, a common feature of channels on terrestrial megafans, are ubiquitous. Desert megafans show cemented paleo-channels as inverted

  19. High-Resolution Image of Europa's Ridged Plains

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This spectacular image taken by NASA's Galileo spacecraft camera shows a region of ridged plains on Jupiter's moon Europa. The plains are comprised of many parallel and cross-cutting ridges, commonly in pairs. The majority of the region is of very bright, but darker material is seen primarily in valleys between ridges. Some of the most prominent ridges have dark deposits along their margins and in their central valleys. Some of this dark material probably moved down the flanks of the ridges and has piled up along their bases. The most prominent ridges are about a kilometer in width (less than a mile). In the top right hand corner of the image the end of a dark wide ridge (about 2 kilometers or 1.2 miles across) is visible. Several deep fractures cut through this ridge and continue into the plains. The brightness of the region suggests that frost covers much of Europa's surface. This image looks different from those obtained earlier in Galileo's mission, because this image was taken with the Sun higher in Europa's sky.

    This image was taken on December 16, 1997 at a range of 1,300 kilometers (800 miles) by Galileo's solid state imaging system. North is to the top of the picture, and the Sun illuminates the surface from the upper left. This image, centered at approximately 14 degrees south latitude and 194 degrees west longitude, covers an area approximately 20 kilometers (12 miles) on each side. The resolution is 26 meters (85 feet) per picture element.

    The Jet Propulsion Laboratory, Pasadena, CA manages the Galileo mission for NASA's Office of Space Science, Washington, DC. JPL is an operating division of California Institute of Technology (Caltech).

    This image and other images and data received from Galileo are posted on the World Wide Web, on the Galileo mission home page at URL http://www.jpl.nasa.gov/ galileo.

  20. Isolated teeth of Anhangueria  (Pterosauria: Pterodactyloidea) from the Lower Cretaceous of Lightning Ridge, New South Wales, Australia

    PubMed Central

    Smith, Elizabeth T.; Bell, Phil R.

    2017-01-01

    The fossil record of Australian pterosaurs is sparse, consisting of only a small number of isolated and fragmentary remains from the Cretaceous of Queensland, Western Australia and Victoria. Here, we describe two isolated pterosaur teeth from the Lower Cretaceous (middle Albian) Griman Creek Formation at Lightning Ridge (New South Wales) and identify them as indeterminate members of the pterodactyloid clade Anhangueria. This represents the first formal description of pterosaur material from New South Wales. The presence of one or more anhanguerian pterosaurs at Lightning Ridge correlates with the presence of ‘ornithocheirid’ and Anhanguera-like pterosaurs from the contemporaneous Toolebuc Formation of central Queensland and the global distribution attained by ornithocheiroids during the Early Cretaceous. The morphology of the teeth and their presence in the estuarine- and lacustrine-influenced Griman Creek Formation is likely indicative of similar life habits of the tooth bearer to other members of Anhangueria. PMID:28480142

  1. Neogene Fault and Feeder Dike Patterns in the Western Ross Sea

    NASA Astrophysics Data System (ADS)

    Magee, W. R.; Wilson, T. J.

    2010-12-01

    In Antarctica, where much of the continent is covered by water and ice, geophysical data from the Antarctic submarine continental shelf is a fundamental part of reconstructing geological history. Multibeam sonar from the western Ross Sea has revealed elongate volcanic edifices and fields of elongate submarine hills on the seafloor. Origin of the submarine hills as carbonate mounds and drumlins have been proposed. The hills are up to ~8000m long and ~3500m wide, and rise 50-100m above the seafloor. Morphometric analysis of the hills shows they are elongate, with axial ratios ranging from 1.2:1 to 2:1, and some hills are linked to form elongate ridges. Seismic profiles show significant pull-ups directly below the hills, consistent with narrow, higher-density magmatic bodies; thus we favor an origin as volcanic seamounts above subsurface feeder dikes. If this volcanic hypothesis is correct, feeder dikes below the hills and elongate volcanic ridges may document magmatically-forced extension within the Terror Rift. The seamount field forms part of a regional en echelon array of volcanic ridges extending NNW from Beaufort Island toward Drygalski Ice Tongue. The ridges and elongate seamount cluster trend NNE, subparallel to mapped fault trends in this sector of the Terror Rift. This geometry is compatible with right-lateral transtension along this zone, as previously proposed for the Terror Rift as a whole. Volcanic islands and dredged volcanic ridges within the en echelon array are dated at ~7-4 Ma, implying Neogene deformation. We are completing a detailed analysis of orientation patterns and cross-cutting relations between faults and volcanic hills and their feeder systems to test this model for Neogene rift kinematics.

  2. Triple Junctions, Boninites, and a New Microplate in the Western Pacific

    NASA Astrophysics Data System (ADS)

    Flores, J. A.; Casey, J.

    2017-12-01

    A new microplate has been discovered while trying to correlate melting processes in subduction zones that are forming boninites along the southern Mariana Plate. The westward boundary between the Mariana plate and the Philippine Sea plate is along a well-defined back-arc spreading center. The southern extension of this spreading center to the intersection with the Mariana Trench does not have a recognized morphological boundary. Previous work has hypothesized that subduction beneath a spreading center provides conditions required for boninite petrogenesis. Therefore, the exact location of the trench-trench-ridge triple junction needs to be found and correlated with known boninite locations. The triple junction was found using fault plane solutions to constrain the southern boundary of the two plates as it transects across the forearc. Normal faults suggest the triple junction to be at approximately 11.9N 144.1W; slip direction of reverse faults associated with the subducting plate are dominantly north-south west of this junction and northwest-southeast on the east side. While locating the southern boundary, the nucleation of a new spreading center that creates a ridge-ridge-ridge triple junction was found. The main spreading center trends mostly north-south until about 12.5N 143W, where two other spreading centers meet. The western spreading zone trends mostly east-west and seems to be in its infancy whereas there is another spreading center trending northwest-southeast. It is this last spreading center that forms the trench-ridge-trench triple junction. Discovery of these triple junctions isolates a piece of lithosphere that we interpret to be a new microplate that we name the Challenger Microplate.

  3. Mechanism for generating the anomalous uplift of oceanic core complexes: Atlantis Bank, southwest Indian Ridge

    NASA Astrophysics Data System (ADS)

    Baines, A. Graham; Cheadle, Michael J.; Dick, Henry J. B.; Hosford Scheirer, Allegra; John, Barbara E.; Kusznir, Nick J.; Matsumoto, Takeshi

    2003-12-01

    Atlantis Bank is an anomalously uplifted oceanic core complex adjacent to the Atlantis II transform, on the southwest Indian Ridge, that rises >3 km above normal seafloor of the same age. Models of flexural uplift due to detachment faulting can account for ˜1 km of this uplift. Postdetachment normal faults have been observed during submersible dives and on swath bathymetry. Two transform-parallel, large-offset (hundreds of meters) normal faults are identified on the eastern flank of Atlantis Bank, with numerous smaller faults (tens of meters) on the western flank. Flexural uplift associated with this transform-parallel normal faulting is consistent with gravity data and can account for the remaining anomalous uplift of Atlantis Bank. Extension normal to the Atlantis II transform may have occurred during a 12 m.y. period of transtension initiated by a 10° change in spreading direction ca. 19.5 Ma. This extension may have produced the 120-km-long transverse ridge of which Atlantis Bank is a part, and is consistent with stress reorientation about a weak transform fault.

  4. Mechanism for generating the anomalous uplift of oceanic core complexes: Atlantis Bank, southwest Indian Ridge

    USGS Publications Warehouse

    Baines, A.G.; Cheadle, Michael J.; Dick, H.J.B.; Scheirer, A.H.; John, Barbara E.; Kusznir, N.J.; Matsumoto, T.

    2003-01-01

    Atlantis Bank is an anomalously uplifted oceanic core complex adjacent to the Atlantis II transform, on the southwest Indian Ridge, that rises >3 km above normal seafloor of the same age. Models of flexural uplift due to detachment faulting can account for ???1 km of this uplift. Postdetachment normal faults have been observed during submersible dives and on swath bathymetry. Two transform-parallel, large-offset (hundreds of meters) normal faults are identified on the eastern flank of Atlantis Bank, with numerous smaller faults (tens of meters) on the western flank. Flexural uplift associated with this transform-parallel normal faulting is consistent with gravity data and can account for the remaining anomalous uplift of Atlantis Bank. Extension normal to the Atlantis II transform may have occurred during a 12 m.y. period of transtension initiated by a 10?? change in spreading direction ca. 19.5 Ma. This extension may have produced the 120-km-long transverse ridge of which Atlantis Bank is a part, and is consistent with stress reorientation about a weak transform fault.

  5. Seismic Velocity Variation and Evolution of the Upper Oceanic Crust across the Mid-Atlantic Ridge at 1.3°S

    NASA Astrophysics Data System (ADS)

    Jian, H.; Singh, S. C.

    2017-12-01

    The oceanic crust that covers >70% of the solid earth is formed at mid-ocean ridges, but get modified as it ages. Understanding the evolution of oceanic crust requires investigations of crustal structures that extend from zero-age on the ridge axis to old crust. In this study, we analyze a part of a 2000-km-long seismic transect that crosses the Mid-Atlantic Ridge segment at 1.3°S, south of the Chain transform fault. The seismic data were acquired using a 12-km-long multi-sensor streamer and dense air-gun shots. Using a combination of downward continuation and seismic tomography methods, we have derived a high-resolution upper crustal velocity structure down to 2-2.5 km depth below the seafloor, from the ridge axis to 3.5 Ma on both sides of the ridge axis. The results demonstrate that velocities increase at all depths in the upper crust as the crust ages, suggesting that hydrothermal precipitations seal the upper crustal pore spaces. This effect is most significant in layer 2A, causing a velocity increase of 0.5-1 km/s after 1-1.5 Ma, beyond which the velocity increase is very small. Furthermore, the results exhibit a significant decrease in both the frequency and amplitude of the low-velocity anomalies associated with faults beyond 1-1.5 Ma, when faults become inactive, suggesting a linkage between the sealing of fault space and the extinction of hydrothermal activity. Besides, the off-axis velocities are systematically higher on the eastern side of the ridge axis compared to on the western side, suggesting that a higher hydrothermal activity should exist on the outside-corner ridge flank than on the inside-corner flank. While the tomography results shown here cover 0-3.5 Ma crust, the ongoing research will further extend the study area to older crust and also incorporating pre-stack migration and full waveform inversion methods to improve the seismic structure.

  6. Glacigenic landforms and sediments of the Western Irish Shelf

    NASA Astrophysics Data System (ADS)

    McCarron, Stephen; Monteys, Xavier; Toms, Lee

    2013-04-01

    Vibrocoring of possible glacigenic landforms identified from high resolution bathymetric coverage of the Irish Shelf by the Irish National Seabed Survey (INSS) has provided several clusters of short (<3m) cores that, due to a regional post-glacial erosional event, comprise last glacial age stratigraphies. In addition, new shallow seismic data and sedimentological information from across the Western Irish Shelf provide new insights into aspects of the nature, timing and pattern of shelf occupation by grounded lobate extensions of the last Irish Ice Sheet. Restricted chronological control of deglacial sequences in several cores indicates that northern parts of the western mid-shelf (south of a prominent outer Donegal Bay ridge) were ice free by ~24 ka B.P., and that ice had also probably retreated from outer shelf positions (as far west as the Porcupine Bank) at or before this time.

  7. Long term evolution and internal architecture of high-energy banner ridges of Mer d'Iroise (Western Brittany, France) : interplay of sea-level, basement morphology, biogenic productivity and hydrodynamics

    NASA Astrophysics Data System (ADS)

    Le Roy, P., Sr.; Le Dantec, N.; Franzetti, M.; Delacourt, C.; Ehrhold, A.

    2016-12-01

    The recent completion of a coupled seismic and swath bathymetric survey, conducted across the Mer d'Iroise (Atlantic continental shelf, France), provided new data for the study of the long term evolution of deep tidal sand ridges. Three major banner sand ridges composed of biogenic sands were investigated: the Banc du Four, the Haut Fond d'Ouessant and the Banc d'Ar Men. Seismic interpretation reveals a compound internal architecture of these sand ridges with a sedimentary core forming the lower units interpreted to be shoreface deposits and overlain by sandwaves. Sandwave climbing, which combines progradation and accretion, is the major process controlling the growth of the ridges. The elevation of the preserved dune foresets reaches values of about 20 to 30 m and indicate a combination of giant dunes characterized by numerous steep (up to 20°) clinoforms corresponding to a high-energy depositional environment. All of the radiocarbon ages of the biogenic surficial deposits of the Banc du Four range from 10,036 to 2,748 cal years B.P. and suggest it has grown during the last sea-level rise. The apparent absence of recent surface deposits could be caused by a change in benthic biogenic productivity or the non-conservation of recent deposits. The multiphase accretion of the ridge is closely linked to the progressive flooding of the coastal promontories and straits that structured the igneous basement. A comparable evolutionary scheme is observed for the Haut-Fond d'Ouessant where a counter-clock wise migration of dunes characterizes the surface of the ridge. In contrast, the Banc d'Ar Men located above a regular basement displays a simpler structure with a consistent Northwestward migration of steep clinoforms. Therefore, the sand ridges of the Mer d'Iroise should be thought of as a representative example of large-scale high-energy banner banks controlled by interaction of sea-level, basement morphology, biogenic productivity, tidal and wave hydrodynamics.

  8. ENVIRONMENTAL BASELINE SURVEY REPORT FOR WEST BLACK OAK RIDGE, EAST BLACK OAK RIDGE, MCKINNEY RIDGE, WEST PINE RIDGE, AND PARCEL 21D IN THE VICINITY OF THE EAST TENNESSEE TECHNOLOGY PARK, OAK RIDGE, TENNESSEE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    David A. King

    2012-11-29

    This environmental baseline survey (EBS) report documents the baseline environmental conditions of five land parcels located near the U.S. Department of Energy’s (DOE’s) East Tennessee Technology Park (ETTP), including West Black Oak Ridge, East Black Oak Ridge, McKinney Ridge, West Pine Ridge, and Parcel 21d. The goal is to obtain all media no-further-investigation (NFI) determinations for the subject parcels considering existing soils. To augment the existing soils-only NFI determinations, samples of groundwater, surface water, soil, and sediment were collected to support all media NFI decisions. The only updates presented here are those that were made after the original issuance ofmore » the NFI documents. In the subject parcel where the soils NFI determination was not completed for approval (Parcel 21d), the full process has been performed to address the soils as well. Preparation of this report included the detailed search of federal government records, title documents, aerial photos that may reflect prior uses, and visual inspections of the property and adjacent properties. Interviews with current employees involved in, or familiar with, operations on the real property were also conducted to identify any areas on the property where hazardous substances and petroleum products, or their derivatives, and acutely hazardous wastes may have been released or disposed. In addition, a search was made of reasonably obtainable federal, state, and local government records of each adjacent facility where there has been a release of any hazardous substance or any petroleum product or their derivatives, including aviation fuel and motor oil, and which is likely to cause or contribute to a release of any hazardous substance or any petroleum product or its derivatives, including aviation fuel or motor oil, on the real property. A radiological survey and soil/sediment sampling was conducted to assess baseline conditions of Parcel 21d that were not addressed by the soils

  9. Rhelogical constraints on ridge formation on Icy Satellites

    NASA Astrophysics Data System (ADS)

    Rudolph, M. L.; Manga, M.

    2010-12-01

    The processes responsible for forming ridges on Europa remain poorly understood. We use a continuum damage mechanics approach to model ridge formation. The main objectives of this contribution are to constrain (1) choice of rheological parameters and (2) maximum ridge size and rate of formation. The key rheological parameters to constrain appear in the evolution equation for a damage variable (D): ˙ {D} = B <<σ >>r}(1-D){-k-α D (p)/(μ ) and in the equation relating damage accumulation to volumetric changes, Jρ 0 = δ (1-D). Similar damage evolution laws have been applied to terrestrial glaciers and to the analysis of rock mechanics experiments. However, it is reasonable to expect that, like viscosity, the rheological constants B, α , and δ depend strongly on temperature, composition, and ice grain size. In order to determine whether the damage model is appropriate for Europa’s ridges, we must find values of the unknown damage parameters that reproduce ridge topography. We perform a suite of numerical experiments to identify the region of parameter space conducive to ridge production and show the sensitivity to changes in each unknown parameter.

  10. The Mathematics of Aggregation, Interdependence, Organizations and Systems of Nash Equilibria (NE): A Replacement for Game Theory

    DTIC Science & Technology

    2011-06-01

    there a free-market economist in the House?, American Journal of Economics and Sociology, 66(2): 309-334. Jasny, B. R., Zahn, L.M., & Marshall, E...1   The Mathematics of Aggregation, Interdependence, Organizations and Systems of Nash equilibria (NE): A replacement for Game Theory...level data to group, organization and systems levels, making it one of social science’s biggest challenges, if not the most important (Giles, 2011). For

  11. Dynamical Instability Produces Transform Faults at Mid-Ocean Ridges

    NASA Astrophysics Data System (ADS)

    Gerya, Taras

    2010-08-01

    Transform faults at mid-ocean ridges—one of the most striking, yet enigmatic features of terrestrial plate tectonics—are considered to be the inherited product of preexisting fault structures. Ridge offsets along these faults therefore should remain constant with time. Here, numerical models suggest that transform faults are actively developing and result from dynamical instability of constructive plate boundaries, irrespective of previous structure. Boundary instability from asymmetric plate growth can spontaneously start in alternate directions along successive ridge sections; the resultant curved ridges become transform faults within a few million years. Fracture-related rheological weakening stabilizes ridge-parallel detachment faults. Offsets along the transform faults change continuously with time by asymmetric plate growth and discontinuously by ridge jumps.

  12. The morphology of the ridge belts on Venus

    NASA Astrophysics Data System (ADS)

    Kriuchkov, V. P.

    1990-06-01

    The length and spacing of linear features were measured for ridge and groove belts, for the outer mountain zones of the Lakshmi planum, and for the outer ridge zones of coronal structures. The distributions of these parameters show small but significant differences in most of the cases. The ridges are assumed to result from deformations. Deformed-layer thickness were estimated for various types of linear subdivisions.

  13. How do long-offset oceanic transforms adapt to plate motion changes? The example of the Western Pacific-Antarctic plate boundary

    NASA Astrophysics Data System (ADS)

    Lodolo, Emanuele; Coren, Franco; Ben-Avraham, Zvi

    2013-03-01

    Oceanic transform faults respond to changes in the direction of relative plate motion. Studies have shown that short-offset transforms generally adjust with slight bends near the ridge axis, while long-offset ones have a remarkably different behavior. The western Pacific-Antarctic plate boundary highlights these differences. A set of previously unpublished seismic profiles, in combination with magnetic anomaly identifications, shows how across a former, ~1250 km long transform (the Emerald Fracture Zone), plate motion changes have produced a complex geometric readjustment. Three distinct sections are recognized along this plate boundary: an eastern section, characterized by parallel, multiple fault strand lineaments; a central section, shallower than the rest of the ridge system, overprinted by a mantle plume track; and a western section, organized in a cascade of short spreading axes/transform lineaments. This configuration was produced by changes that occurred since 30 Ma in the Australia-Pacific relative plate motion, combined with a gradual clockwise change in Pacific-Antarctic plate motion. These events caused extension along the former Emerald Fracture Zone, originally linking the Pacific-Antarctic spreading ridge system with the Southeast Indian ridge. Then an intra-transform propagating ridge started to develop in response to a ~6 Ma change in the Pacific-Antarctic spreading direction. The close proximity of the Euler poles of rotation amplified the effects of the geometric readjustments that occurred along the transform system. This analysis shows that when a long-offset transform older than 20 Ma is pulled apart by changes in spreading velocity vectors, it responds with the development of multiple discrete, parallel fault strands, whereas in younger lithosphere, locally modified by thermal anisotropies, tensional stresses generate an array of spreading axes offset by closely spaced transforms.

  14. A deep structural ridge beneath central India

    NASA Astrophysics Data System (ADS)

    Agrawal, P. K.; Thakur, N. K.; Negi, J. G.

    A joint-inversion of magnetic satellite (MAGSAT) and free air gravity data has been conducted to quantitatively investigate the cause for Bouguer gravity anomaly over Central Indian plateaus and possible fold consequences beside Himalayan zone in the Indian sub-continent due to collision between Indian and Eurasian plates. The appropriate inversion with 40 km crustal depth model has delineated after discriminating high density and magnetisation models, for the first time, about 1500 km long hidden ridge structure trending NW-SE. The structure is parallel to Himalayan fold axis and the Indian Ocean ridge in the Arabian Sea. A quantitative relief model across a representative anomaly profile confirms the ridge structure with its highest point nearly 6 km higher than the surrounding crustal level in peninsular India. The ridge structure finds visible support from the astro-geoidal contours.

  15. 27 CFR 9.158 - Mendocino Ridge.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Mendocino Ridge. 9.158 Section 9.158 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.158 Mendocino Ridge. (a) Name. The name of the...

  16. 27 CFR 9.158 - Mendocino Ridge.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Mendocino Ridge. 9.158 Section 9.158 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.158 Mendocino Ridge. (a) Name. The name of the...

  17. 27 CFR 9.158 - Mendocino Ridge.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Mendocino Ridge. 9.158 Section 9.158 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.158 Mendocino Ridge. (a) Name. The name of the...

  18. 27 CFR 9.158 - Mendocino Ridge.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Mendocino Ridge. 9.158 Section 9.158 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.158 Mendocino Ridge. (a) Name. The name of the...

  19. 27 CFR 9.158 - Mendocino Ridge.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Mendocino Ridge. 9.158 Section 9.158 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.158 Mendocino Ridge. (a) Name. The name of the...

  20. Student Health Services at Orchard Ridge.

    ERIC Educational Resources Information Center

    Nichols, Don D.

    This paper provides a synoptic review of student health services at the community college level while giving a more detailed description of the nature of health services at Orchard Ridge, a campus of Oakland Community College. The present College Health Service program provides for a part-time (24 hrs./wk.) nurse at Orchard Ridge. A variety of…

  1. Vitamin B5 and N-acetylcysteine in nonalcoholic steatohepatitis: a pre-clinical study in a dietary mouse model

    PubMed Central

    Machado, Mariana Verdelho; Kruger, Leandi; Jewell, Mark L.; Michelotti, Gregory Alexander; de Almeida Pereira, Thiago; Xie, Guanhua; Moylan, Cynthia A.; Diehl, Anna Mae

    2015-01-01

    Background Nonalcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease and second indication for liver transplantation in the Western world. Effective therapy is still not available. Previously we showed a critical role for caspase-2 in the pathogenesis of nonalcoholic steatohepatitis (NASH), the potentially progressive form of NAFLD. An imbalance between free Coenzyme A (CoA) and acyl-CoA ratio is known to induce caspase-2 activation. Objectives We aimed to evaluate CoA metabolism and the effects of supplementation with CoA precursors, pantothenate and cysteine, in mouse models of NASH. Methods CoA metabolism was evaluated in methionine-choline deficient (MCD) and Western diet mouse models of NASH. MCD-diet fed mice were treated with pantothenate and N-acetylcysteine or placebo to determine effects on NASH. Results Liver free CoA content was reduced, pantothenate kinase (PANK), the rate-limiting enzyme in the CoA biosynthesis pathway, was down-regulated, and CoA degrading enzymes were increased in mice with NASH. Decreased hepatic free CoA content was associated with increased caspase-2 activity, and correlated with worse liver cell apoptosis, inflammation and fibrosis. Treatment with pantothenate and N-acetylcysteine did not inhibit caspase-2 activation, improve NASH, normalize PANK expression, or restore free CoA levels in MCD diet-fed mice. Conclusion In mice with NASH, hepatic CoA metabolism is impaired, leading to decreased free CoA content, activation of caspase-2, and increased liver cell apoptosis. Dietary supplementation with CoA precursors did not restore CoA levels or improve NASH, suggesting that alternative approaches are necessary to normalize free CoA during NASH. PMID:26403427

  2. Alkalic Basalt in Ridge Axis of 53˚E Amagmatic Segment Center, Southwest Indian Ridge

    NASA Astrophysics Data System (ADS)

    Zhou, H.; Wang, J.; Liu, Y.; Ji, F.; Dick, H. J.

    2014-12-01

    Mid-ocean ridge basalt (MORB) is key tracer of composition and process in the mantle. It is interesting to notice that some alkalic basalts occur in amagmatic spreading center of ultraslow spreading ridges, for examples, 9-16˚E of the Southwest Indian ridge (Standish et al., 2008) and Lena Trough of Arctic Ocean (Snow et al., 2011). The latter is interpreted as the result of the pre-existence of continental transform fault or the especially cold thermal structure of ancient continental lithosphere. 53˚E segment, east of the Gallieni transform fault, was discovered as an amagmatic segment (Zhou and Dick, 2013). On both sides of the ridge axis, peridotites with a little gabbro are exposed in an area more than 3200 km2. Basalts exist in the southern portion of 53˚E segment, indicating the transformation from magmatic to amagmatic spreading about 9.4 million years ago. In April of 2014, Leg 4 of the RV Dayang Yihao cruise 30, basaltic glasses was dredged at one location (3500 m water depth) in the ridge axis of 53˚E segment center. It is shown by electric probe analysis that the samples have extremely high sodium content (4.0-4.49 wt% Na­2O ), relative higher potassium content (0.27-0.32 wt% K2O) and silica (50.67-51.87 wt% SiO2), and lower MgO content (5.9-6.4 wt% MgO). Mg-number is 0.55-0.59. It is distinctly different from the N-MORB (2.42-2.68 wt% Na2O, 0.03-0.06 wt% K2O, 48.6-49.6 wt% Si2O, 8.8-9.0 wt% MgO, Mg-numbers 0.63) distributed in the 560-km-long supersegment, west of the Gallieni transform fault, where the active Dragon Flag hydrothermal field was discovered at 49.6˚E in 2007. The reasons for the alkalic basalt in the ridge axis of 53˚E amagmatic segment center, either by low melting degree of garnet stability field, by melting from an ancient subcontinental lithospheric mantle, or by sodium-metasomatism or even other mantle processes or their combination in the deep mantle, are under further studies.

  3. Tectonics of the Western Gulf of Oman

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    White, R.S.; Ross, D.A.

    1979-07-10

    The Oman line, running northward from the Strait of Hormuz separates a continent-continent plate boundary to the northwest (Persian Gulf region) from an ocean-continent plate boundary to the southeast (Gulf of Oman region). A large basement ridge detected on multichannel seismic reflection and gravity profiles to the west of the Oman line is probably a subsurface continuation of the Musandam peninsula beneath the Strait of Hormuz. Collision and underthrusting beneath Iran of the Arabian plate on which this ridge lies has caused many of the large earthquakes that have occurred in this region. Convergence between the oceanic crust of themore » Arabian plate beneath the Gulf of Oman and the continental Eurasian plate beneath Iran to the north is accommodated by northward dipping subduction. A deformed sediment prism which forms the offshore Makran continental margin and which extends onto land in the Iranian Makran has accumulated above the descending plate. In the western part of the Gulf of Oman, continued convergence has brought the opposing continental margin of Oman into contact with the Makran continental margin. This is an example of the initial stages of a continent-continent type collision. A model of imbricate thrusting is proposed to explain the development of the fold ridges and basins on the Makran continental margin. Sediments from the subducting plate are buckled and incorporated into the edge of the Makran continental margin in deformed wedges and subsequently uplifted along major faults that penetrate the accretionary prism further to the north.« less

  4. Ridge Waveguide Structures in Magnesium-Doped Lithium Niobate

    NASA Technical Reports Server (NTRS)

    Himmer, Phillip; Battle, Philip; Suckow, William; Switzer, Greg

    2011-01-01

    This work proposes to establish the feasibility of fabricating isolated ridge waveguides in 5% MgO:LN. Ridge waveguides in MgO:LN will significantly improve power handling and conversion efficiency, increase photonic component integration, and be well suited to spacebased applications. The key innovation in this effort is to combine recently available large, high-photorefractive-damage-threshold, z-cut 5% MgO:LN with novel ridge fabrication techniques to achieve high-optical power, low-cost, high-volume manufacturing of frequency conversion structures. The proposed ridge waveguide structure should maintain the characteristics of the periodically poled bulk substrate, allowing for the efficient frequency conversion typical of waveguides and the high optical damage threshold and long lifetimes typical of the 5% doped bulk substrate. The low cost and large area of 5% MgO:LN wafers, and the improved performance of the proposed ridge waveguide structure, will enhance existing measurement capabilities as well as reduce the resources required to achieve high-performance specifications. The purpose of the ridge waveguides in MgO:LN is to provide platform technology that will improve optical power handling and conversion efficiency compared to existing waveguide technology. The proposed ridge waveguide is produced using standard microfabrication techniques. The approach is enabled by recent advances in inductively coupled plasma etchers and chemical mechanical planarization techniques. In conjunction with wafer bonding, this fabrication methodology can be used to create arbitrarily shaped waveguides allowing complex optical circuits to be engineered in nonlinear optical materials such as magnesium doped lithium niobate. Researchers here have identified NLO (nonlinear optical) ridge waveguide structures as having suitable value to be the leading frequency conversion structures. Its value is based on having the low-cost fabrication necessary to satisfy the challenging pricing

  5. Ridge-crossing mantle plumes and gaps in tracks

    NASA Astrophysics Data System (ADS)

    Sleep, Norman H.

    2002-12-01

    Hot spot tracks approach, cross, and leave ridge axes. The complications of this process make it difficult to determine the track followed by a plume and the evolution of its vigor. When a plume is sufficiently near the ridge axis, buoyant plume material flows along the base of the lithosphere toward the axis, forming an on-axis hot spot. The track of the on-axis hot spot is a symmetric V on both plates and an unreliable indication of the path followed by the plume. Aseismic ridges form more or less along flowlines from a plume to a ridge axis when channels form at the base of the lithosphere. A dynamic effect is that off-axis hot spots appear to shut off at the time that an on-axis hot spot becomes active along an axis-approaching track. This produces a gap in the obvious track and a jump of the hot spot to the ridge axis. The gap results from the effects of ponded plume material on intraplate (membrane) stress. Membrane tension lets dikes ascend efficiently to produce obvious tracks of edifices. An off-axis hot spot shuts down when the plume is sufficiently near the ridge axis that plume material flows there, putting the nearby lithosphere above the plume into compression, preventing dikes. In addition, the off-axis thickness of plume material, which produces membrane tension, decreases as the slope of the base of the lithosphere increases beneath young lithosphere. Slow spreading rates favor gaps produced in this way. Gaps are observed near both fast and slow ridges.

  6. Determinants of alveolar ridge preservation differ by anatomic location

    PubMed Central

    Leblebicioglu, Binnaz; Salas, Mabel; Ort, Yirae; Johnson, Ashley; Yildiz, Vedat O.; Kim, Do-Gyoon; Agarwal, Sudha; Tatakis, Dimitris N.

    2016-01-01

    Aim To investigate and compare outcomes following alveolar ridge preservation (ARP) in posterior maxilla and mandible. Methods Twenty-four patients (54 ± 3 years) with single posterior tooth extraction were included. ARP was performed with freeze-dried bone allograft and collagen membrane. Clinical parameters were recorded at extraction and re-entry. Harvested bone cores were analysed by microcomputed tomography (micro-CT), histomorphometry and immunohistochemistry. Results In both jaws, ARP prevented ridge height loss, but ridge width was significantly reduced by approximately 2.5 mm. Healing time, initial clinical attachment loss and amount of keratinized tissue at extraction site were identified as determinants of ridge height outcome. Buccal plate thickness and tooth root length were identified as determinants of ridge width outcome. In addition, initial ridge width was positively correlated with ridge width loss. Micro-CT revealed greater mineralization per unit volume in new bone compared with existing bone in mandible (p < 0.001). Distributions of residual graft, new cellular bone and immature tissue were similar in both jaws. Conclusion Within the limitations of this study, the results indicate that in different anatomic locations different factors may determine ARP outcomes. Further studies are needed to better understand determinants of ARP outcomes. PMID:23432761

  7. Alternative Fuels Data Center: Blue Ridge Parkway Incorporates Alternative

    Science.gov Websites

    Fuels in Its Fleet Blue Ridge Parkway Incorporates Alternative Fuels in Its Fleet to someone by E-mail Share Alternative Fuels Data Center: Blue Ridge Parkway Incorporates Alternative Fuels in Its Fleet on Facebook Tweet about Alternative Fuels Data Center: Blue Ridge Parkway Incorporates Alternative

  8. Curiosity at Gale Crater's Hematite Ridge: High Mn and P Near the Ridge Show Chemical Evidence for Generation by an Oxidation Front

    NASA Astrophysics Data System (ADS)

    Wiens, R. C.; Meslin, P. Y.; Lanza, N.; Frydenvang, J.; Mangold, N.; Johnson, J. R.; Fraeman, A. A.; Horgan, B.; Bedford, C.; Blaney, D. L.; Bridges, J.; Cousin, A.; Ehlmann, B. L.; Forni, O.; Gasda, P. J.; Gasnault, O.; Gellert, R.; Johnstone, S.; Lamm, S. N.; Lasue, J.; Le Mouelic, S.; Maurice, S.; Newsom, H. E.; Ollila, A.; Payre, V.; Rapin, W.; Salvatore, M. R.; Schwenzer, S. P.; Thomas, N. H.; Vasavada, A. R.

    2017-12-01

    After traversing >17 km, the Curiosity rover has reached Vera Rubin Ridge (VRR), formerly known as the Hematite Ridge. Situated 200 m above the base of Gale crater on the slope of Mt. Sharp, VRR was one of the original objectives of the mission. VRR stretches 6.5 km NE-SW with a vertical height of 30 m (to -4200 m), it is the largest surface feature encountered by Curiosity to date. Orbital observation by CRISM of relatively strong hematite signal along the ridge gave it its original name. Some hematite spectral signatures along the ridge have been observed by Curiosity from long distance by Mastcam and ChemCam passive spectra. Curiosity started observing local enrichments of hematite in Murray lacustrine sediments near Bagnold Dunes, which may or may not be related to the hematite observed on the ridge top. The presence of hematite-like spectral signatures became variable as the rover approached below the ridge. Chemistry and ridge imaging: Magnesium, Mn, and P have shown strong increases in dark surface features in some regions below the ridge. Manganese oxide abundances have risen to >10 wt. % in some dark nodules and laminae. Iron, Mg, and P appear correlated in high-P observations, with the highest values associated with vein-related inclusions. Another class of dark features shows high Fe without high Mn or P. ChemCam high-resolution imaging from within 100 m of the base of the ridge shows regions of both finely laminated parallel strata and low-angle cross stratification along with vertical fractures surrounded by alteration halos; these are comparable to Murray stratigraphy. Given that the exposed surface of the Murray formation is the result of significant erosional deflation, the ridge must be more erosionally resistant than the surrounding material. The observation of high-oxidation-potential element enrichments below VRR argues for an oxidation front in which the local sediments were enriched in oxidized iron (hematite) and manganese. In this

  9. Asymmetric sea-floor spreading caused by ridge-plume interactions

    NASA Astrophysics Data System (ADS)

    Müller, R. Dietmar; Roest, Walter R.; Royer, Jean-Yves

    1998-12-01

    Crustal accretion at mid-ocean ridges is generally modelled as a symmetric process. Regional analyses, however, often show either small-scale asymmetries, which vary rapidly between individual spreading corridors, or large-scale asymmetries represented by consistent excess accretion on one of the two separating plates over geological time spans. In neither case is the origin of the asymmetry well understood. Here we present a comprehensive analysis of the asymmetry of crustal accretion over the past 83Myr based on a set of self-consistent digital isochrons and models of absolute plate motion,. We find that deficits in crustal accretion occur mainly on ridge flanks overlying one or several hotspots. We therefore propose that asymmetric accretion is caused by ridge propagation towards mantle plumes or minor ridge jumps sustained by asthenospheric flow, between ridges and plumes. Quantifying the asymmetry of crustal accretion provides a complementary approach to that based on geochemical and other geophysical data, in helping to unravel how mantle plumes and mid-ocean ridges are linked through mantle convection processes.

  10. Widespread Mega-Pockmarks Imaged Along the Western Edge of the Cocos Ridge

    NASA Astrophysics Data System (ADS)

    Gibson, J. C.; Kluesner, J. W.; Silver, E. A.; Bangs, N. L.; McIntosh, K. D.

    2012-12-01

    A large field (245km2) of 31 seabed mega-pockmarks was imaged between the Cocos ridge and the Quepos plateau on ~16.5 Ma oceanic crust generated at the Cocos-Nazca spreading center. The imaged pockmarks represent only a fraction of the much larger pockmark field evident in 100 m grid cell bathymetry data secured from MGDS. The pockmarks are clustered around 1800-2100 mbsl and were mapped using EM122 multibeam sonar, a 3.5 kHz sub-bottom profiler, and 3D Multi-Channel Seismic (MCS) aboard R/V Marcus G. Langseth during the CRISP seismic survey (2011). Using a constrained swath width of 1.4 km, the increased sounding density facilitated bathymetry/backscatter to be gridded at 10m and 8m respectively. The diameter of the pockmarks varies from ~1 km to ~2 km with a relief range of ~30-80 m, and average slopes of 15°. The MCS data also reveal older buried pockmarks in trench adjacent sediments. Small high-backscatter mounds occur within a subset of the pockmarks, which may indicate bioherms or carbonate banks above focused fluid flow conduits. Based on drilling results of DSDP Site 158 and ODP Site 1381, the pockmarks appear to be the result of paleo-differential advancement of a silica diagenetic front (opal-A to opal-CT). Although, the pockmarks may be erosional features sourced at depth from dewatering of sediments inter-bedded with igneous layers.

  11. DISTINCTIVE FINE-SCALE MORPHOLOGY OF HYDRATE RIDGE

    NASA Astrophysics Data System (ADS)

    Conlin, D.; Paull, C. K.; Caress, D. W.; Thomas, H.; Ussler, W.; Lundsten, E.; Thompson, D.

    2009-12-01

    High-resolution multibeam bathymetry (vertical precision of 0.15 m and horizontal resolution of 1.0 m) collected using an autonomous underwater vehicle (AUV) reveals in unprecedented detail the fine-scale morphology of the ridge crests on Hydrate Ridge, offshore Oregon. An inertial navigation system combined with a doppler velocity sonar allowed the AUV to fly pre-programmed grids with 150 m line spacing at 3 knots while maintaining an altitude of 50 m above the bottom. The data were collected on two 17.5-hour-long dives, one covering a 4.3 x 1.9 km area on the southern crest of Hydrate Ridge (769 to 930 m water depths) and the other covering a 5.2 x 2 km area on the northern crest of Hydrate Ridge (584 to 985 m water depths). These surveys cover the seafloor associated with gas hydrate research boreholes at ODP Sites 891 and 1245 to 1250). The southern crest of Hydrate Ridge is an area being considered for a cable-connected seafloor observatory. The surface of southern Hydrate Ridge is generally smooth except for two approximately circular patches with maximum diameters of 350 m and 500 m associated with a distinctive hummocky topography. The geometric relationships indicate that the edges of these patches are surrounded with small apparently erosional scarps and thus the strata exposed within the patches are stratigraphically lower than the surrounding smooth seafloor. The fine scale-topography within these patches is characterized by a highly irregular surface formed by small, sometimes circular ~0.5 m deep pits, local highs and lows separated by ~0.5 high ledges that could be formed by irregularly eroded bedding surfaces. Similar shapes also occur at larger scales. For example, a previously described feature called the “pinnacle” is a ~15 m topographic high in the center of one of these hummocky patches. The surface of northern Hydrate Ridge has similar patches of hummocky topography. However, the patches are more numerous, associated with greater relief

  12. CHIP−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

    PubMed Central

    Kim, Sung-Mi; Grenert, James P.; Patterson, Cam; Correia, Maria Almira

    2016-01-01

    Genetic ablation of C-terminus of Hsc70-interacting protein (CHIP) E3 ubiquitin-ligase impairs hepatic cytochrome P450 CYP2E1 degradation. Consequent CYP2E1 gain of function accelerates reactive O2 species (ROS) production, triggering oxidative/proteotoxic stress associated with sustained activation of c-Jun NH2-terminal kinase (JNK)-signaling cascades, pro-inflammatory effectors/cytokines, insulin resistance, progressive hepatocellular ballooning and microvesicular steatosis. Despite this, little evidence of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) was found in CHIP−/−-mice over the first 8–9-months of life. We herein document that this lack of tissue injury is largely due to the concurrent up-regulation and/or activation of the adiponectin-5′-AMP-activated protein kinase (AMPK)-forkhead box O (FOXO)-signaling axis stemming from at the least three synergistic features: Up-regulated expression of adipose tissue adiponectin and its hepatic adipoR1/adipoR2 receptors, stabilization of hepatic AMPKα1-isoform, identified herein for the first time as a CHIP-ubiquitination substrate (unlike its AMPKα2-isoform), as well as nuclear stabilization of FOXOs, well-known CHIP-ubiquitination targets. Such beneficial predominance of the adiponectin-AMPK-FOXO-signaling axis over the sustained JNK-elevation and injurious insulin resistance in CHIP−/−-livers apparently counteracts/delays rapid progression of the hepatic microvesicular steatosis to the characteristic macrovesicular steatosis observed in clinical NASH and/or rodent NASH-models. PMID:27406999

  13. Topography and tectonics of mid-oceanic ridge axes

    NASA Technical Reports Server (NTRS)

    Sleep, N. H.; Rosendahl, B. R.

    1979-01-01

    Numerical fluid dynamic models of mid-oceanic ridge axes were constructed using distributions of material properties constrained by seismic studies and thermal calculations. The calculations indicate that spreading is passive except for forces caused by density differences due to thermal expansion and partial melt. Except for geometric differences due to temperature distribution, one set of mechanical properties can adequately explain central rifts of slow ridges and central peaks of fast ridges. Viscous head loss in the upwelling material dominates at low spreading rates where material ascends through a narrow conduit. Thermal expansion and partial melting dominate at high spreading rates where a wide low viscosity crustal magma chamber is present. The preferred rheology is 10 to the 20th poise for the upwelling lithosphere; less than 5 x 10 to the 17th for the crustal magma chamber and axial intrusion zone at fast ridges, and a yield stress of 200 bars for the lithosphere. The calculation correctly predicts the existence of central peaks at 'hot-spot' ridges, where seismic evidence indicates a large magma chamber.

  14. 1. GENERAL VIEW OF ENTRANCE TO BLUE RIDGE TUNNEL (LEFT) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. GENERAL VIEW OF ENTRANCE TO BLUE RIDGE TUNNEL (LEFT) FROM SOUTHEAST. ORIGINAL BLUE RIDGE R.R. (CROZET) TUNNEL IS VISIBLE AT RIGHT. - Chesapeake & Ohio Railroad, Blue Ridge Tunnel, Highway 250 at Rockfish Gap, Afton, Nelson County, VA

  15. Fuzzy and process modelling of contour ridge water dynamics

    NASA Astrophysics Data System (ADS)

    Mhizha, Alexander; Ndiritu, John

    2018-05-01

    Contour ridges are an in-situ rainwater harvesting technology developed initially for soil erosion control but are currently also widely promoted for rainwater harvesting. The effectiveness of contour ridges depends on geophysical, hydro-climatic and socio economic factors that are highly varied in time and space. Furthermore, field-scale data on these factors are often unavailable. This together with the complexity of hydrological processes at field scale limits the application of classical distributed process modelling to highly-instrumented experimental fields. This paper presents a framework that combines fuzzy logic and process-based approach for modelling contour ridges for rainwater harvesting where detailed field data are not available. Water balance for a representative contour-ridged field incorporating the water flow processes across the boundaries is integrated with fuzzy logic to incorporate the uncertainties in estimating runoff. The model is tested using data collected during the 2009/2010 and 2010/2011 rainfall seasons from two contour-ridged fields in Zhulube located in the semi-arid parts of Zimbabwe. The model is found to replicate soil moisture in the root zone reasonably well (NSE = 0.55 to 0.66 and PBIAS = -1.3 to 6.1 %). The results show that combining fuzzy logic and process based approaches can adequately model soil moisture in a contour ridged-field and could help to assess the water dynamics in contour ridged fields.

  16. Multiple expressions of plume-ridge interaction in the Galápagos: Volcanic lineaments and ridge jumps

    NASA Astrophysics Data System (ADS)

    Mittelstaedt, E.; Soule, S.; Harpp, K.; Fornari, D.; McKee, C.; Tivey, M.; Geist, D.; Kurz, M. D.; Sinton, C.; Mello, C.

    2012-05-01

    Anomalous volcanism and tectonics between near-ridge mantle plumes and mid-ocean ridges provide important insights into the mechanics of plume-lithosphere interaction. We present new observations and analysis of multibeam, side scan sonar, sub-bottom chirp, and total magnetic field data collected during the R/V Melville FLAMINGO cruise (MV1007; May-June, 2010) to the Northern Galápagos Volcanic Province (NGVP), the region between the Galápagos Archipelago and the Galápagos Spreading Center (GSC) on the Nazca Plate, and to the region east of the Galápagos Transform Fault (GTF) on the Cocos Plate. The NGVP exhibits pervasive off-axis volcanism related to the nearby Galápagos hot spot, which has dominated the tectonic evolution of the region. Observations indicate that ˜94% of the excess volcanism in our survey area occurs on the Nazca Plate in three volcanic lineaments. Identified faults in the NGVP are consistent with normal ridge spreading except for those within a ˜60 km wide swath of transform-oblique faults centered on the GTF. These transform-oblique faults are sub-parallel to the elongation direction of larger lineament volcanoes, suggesting that lineament formation is influenced by the lithospheric stress field. We evaluate current models for lineament formation using existing and new observations as well as numerical models of mantle upwelling and melting. The data support a model where the lithospheric stress field controls the location of volcanism along the lineaments while several processes likely supply melt to these eruptions. Synthetic magnetic models and an inversion for crustal magnetization are used to determine the tectonic history of the study area. Results are consistent with creation of the GTF by two southward ridge jumps, part of a series of jumps that have maintained a plume-ridge separation distance of 145 km to 215 km since ˜5 Ma.

  17. Modeling an exogenic origin for the equatorial ridge on Iapetus

    NASA Astrophysics Data System (ADS)

    Stickle, Angela M.; Roberts, James H.

    2018-06-01

    Iapetus has a ridge along the equator that extends continuously for more than 110° in longitude. Parts of the ridge rise as much as 20 km above the surrounding terrains. Most models for the formation of this enigmatic ridge are endogenic, generally requiring the formation of a fast-spinning Iapetus with an oblate shape due to the rotation speed. Many of these require specific scenarios and have constraining parameters in order to generate a ridge comparable to what is seen today. An exogenic formation mechanism has also been proposed, that the ridge represents the remains of an early ring system around Iapetus that collapsed onto the surface. Thus far, none of the models have conclusively identified the origin of the ridge. In this study, an exogenic origin for the ridge is assumed, which is derived from a collapsing disk of debris around Iapetus, without invoking any specific model for the generation of the debris disk. Here, we evaluate whether it is possible to generate a ridge of the size and shape as observed by simulating the impact of the collapsing debris using the CTH hydrocode. Pi-scaling calculations suggest that extremely oblique impact angles (1°-10°) are needed to add to ridge topography. These extreme impact angles severely reduce the cratering efficiency compared to a vertical impact, adding material rather than eroding it during crater formation. Furthermore, material is likely to be excavated at low angles, enhancing downrange accumulation. Multiple impacts from debris pieces will heighten this effect. Because infalling debris is predicted to impact at extremely low angles, both of these effects might have contributed to ridge formation on Iapetus. The extreme grazing angles of the impacts modeled here decouple much of the projectile energy from the target, and impact heating of the surface is not significant. These models suggest that a collapsing disk of debris should have been able to build topography to create a ridge around Iapetus.

  18. Recent faulting and microearthquakes at the intersection of the Vema Fracture Zone and the Mid-Atlantic Ridge

    NASA Astrophysics Data System (ADS)

    Rowlett, Hugh; Forsyth, Donald W.

    1984-07-01

    New air gun reflection profiles, 3.5-kHz reflection profiles, and microearthquake data recorded by an array of ocean bottom seismographs form the basis for this study of the transition from a spreading center to a major transform fault. Disturbances of the thick, normally flat-lying, turbidite deposits provide indications of recent vertical motions. At the western intersection of the fracture zone with the median valley there is a depression in the sediments that represents the southerly extension of the median valley into the fracture zone valley. The depression is terminated abruptly on the south by the active transform fault, which acts as a locus for vertical as well as horizontal displacement. Flat-lying, undisturbed sediments terminate abruptly at the fault. The western boundary of the depression is much broader and is characterized by a series of slumplike steps. To the west, there is little or no evidence for uplift or tilting of sediments which might indicate vertical recovery of the crust as it spreads away from the depression. This suggests that uplift and recovery out of the depression is episodic in nature and has been inactive over the last million years along the western boundary. To the east there is clear evidence of uplift and tilting of sedimentary layers. A basement ridge emerging from the sediments is currently being uplifted and rotated in a manner analogous to processes responsible for the creation and cancellation of median valley relief. The transition between the spreading center and the transform fault appears to take place within 1-2 km. The width of the transform fault just east of the depression is less than a kilometer. Microearthquakes were located and displayed by new methods that directly account for nonlinearities associated with small arrays. Microearthquakes located by three or more ocean bottom seismometers show that the greatest seismic activity occurs along the eastern walls of the median valley, at the basement ridge, in the

  19. Oak Ridge reservation land-use plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bibb, W. R.; Hardin, T. H.; Hawkins, C. C.

    1980-03-01

    This study establishes a basis for long-range land-use planning to accommodate both present and projected DOE program requirements in Oak Ridge. In addition to technological requirements, this land-use plan incorporates in-depth ecological concepts that recognize multiple uses of land as a viable option. Neither environmental research nor technological operations need to be mutually exclusive in all instances. Unique biological areas, as well as rare and endangered species, need to be protected, and human and environmental health and safety must be maintained. The plan is based on the concept that the primary use of DOE land resources must be to implementmore » the overall DOE mission in Oak Ridge. This document, along with the base map and overlay maps, provides a reasonably detailed description of the DOE Oak Ridge land resources and of the current and potential uses of the land. A description of the land characteristics, including geomorphology, agricultural productivity and soils, water courses, vegetation, and terrestrial and aquatic animal habitats, is presented to serve as a resource document. Essentially all DOE land in the Oak Ridge area is being fully used for ongoing DOE programs or has been set aside as protected areas.« less

  20. Structure of the Malpelo Ridge (Colombia) from seismic and gravity modelling

    NASA Astrophysics Data System (ADS)

    Marcaillou, Boris; Charvis, Philippe; Collot, Jean-Yves

    2006-12-01

    Wide-angle and multichannel seismic data collected on the Malpelo Ridge provide an image of the deep structure of the ridge and new insights on its emplacement and tectonic history. The crustal structure of the Malpelo Ridge shows a 14 km thick asymmetric crustal root with a smooth transition to the oceanic basin southeastward, whereas the transition is abrupt beneath its northwestern flank. Crustal thickening is mainly related to the thickening of the lower crust, which exhibits velocities from 6.5 to 7.4 km/s. The deep structure is consistent with emplacement at an active spreading axis under a hotspot like the present-day Galapagos Hotspot on the Cocos-Nazca Spreading Centre. Our results favour the hypothesis that the Malpelo Ridge was formerly a continuation of the Cocos Ridge, emplaced simultaneously with the Carnegie Ridge at the Cocos-Nazca Spreading Centre, from which it was separated and subsequently drifted southward relative to the Cocos Ridge due to differential motion along the dextral strike-slip Panama Fracture Zone. The steep faulted northern flank of the Malpelo Ridge and the counterpart steep and faulted southern flank of Regina Ridge are possibly related to a rifting phase that resulted in the Coiba Microplate’s separation from the Nazca Plate along the Sandra Rift.

  1. Melt distribution along the axis of ultraslow spreading mid-ocean ridges

    NASA Astrophysics Data System (ADS)

    Schlindwein, V. S. N.; Schmid, F.; Meier, M.

    2017-12-01

    Ultraslow spreading mid-ocean ridges (<15 mm/y full spreading rate) differ from faster spreading ridges by their uneven melt distribution. Crustal thickness varies along axis from zero to more than 8 km at volcanic centers. These volcanic centers receive more melt than the regional average and may be sustained for millions of years. The segmentation pattern and active volcanism at ultraslow spreading ridges greatly differs from faster spreading ridges. Using networks of ocean bottom seismometers at three differing ridge segments, we could show that the maximum depth of brittle faulting, equivalent approximately to temperatures of 600-700°C, varies drastically along axis. Ridge sections that lack an igneous crust exhibit a thick lithosphere as evidenced by the deepest mid-ocean ridge earthquakes observed so far at more than 30 km depth. Beneath areas of basalt exposure, in particular beneath pronounced volcanic centers, the axial lithosphere may be more than 15 km thinner allowing for melt flow at the base of the lithosphere towards the volcanoes, a process that has been postulated to explain the uneven along-axis melt distribution. Spreading events at ultraslow spreading ridges are unusual as we found from two spreading episodes at 85°E Gakkel Ridge and Segment 8 volcano on the Southwest Indian Ridge. These eruptions were preceded or accompanied by large (M>5) and long-lasting earthquake swarms and active magmatism lasted over 3-16 years. A massive hydrothermal event plume and sounds from deep submarine explosive volcanism were observed at Gakkel Ridge. At the Segment 8 volcano, we imaged a melt reservoir extending to about 8 km depth below the volcano that potentially fed a sill intrusion recorded by an ocean bottom seismometers about 30 km away at a neighboring subordinate volcanic center. To better understand the segmentation and melt transport at ultraslow spreading rigdes, we recently conducted a segment-scale seismicity survey of Knipovich Ridge in the

  2. Custom Titanium Ridge Augmentation Matrix (CTRAM): A Case Report.

    PubMed

    Connors, Christopher A; Liacouras, Peter C; Grant, Gerald T

    2016-01-01

    This is a case report of a custom titanium ridge augmentation matrix (CTRAM). Using cone beam computed tomography (CBCT), a custom titanium space-maintaining device was developed. Alveolar ridges were virtually augmented, a matrix was virtually designed, and the CTRAM was additively manufactured with titanium (Ti6Al4V). Two cases are presented that resulted in sufficient increased horizontal bone volume with successful dental implant placement. The CTRAM design allows for preoperative planning for increasing alveolar ridge dimensions to support dental implants, reduces surgical time, and prevents the need for a second surgical site to gain sufficient alveolar ridge bone volume for dental implant therapy.

  3. Normalization Ridge Regression in Practice I: Comparisons Between Ordinary Least Squares, Ridge Regression and Normalization Ridge Regression.

    ERIC Educational Resources Information Center

    Bulcock, J. W.

    The problem of model estimation when the data are collinear was examined. Though the ridge regression (RR) outperforms ordinary least squares (OLS) regression in the presence of acute multicollinearity, it is not a problem free technique for reducing the variance of the estimates. It is a stochastic procedure when it should be nonstochastic and it…

  4. Hydrodynamic role of longitudinal ridges in a leatherback turtle swimming

    NASA Astrophysics Data System (ADS)

    Bang, Kyeongtae; Kim, Jooha; Lee, Sang-Im; Choi, Haecheon

    2015-11-01

    The leatherback sea turtle (Dermochelys coriacea), the fastest swimmer and the deepest diver among marine turtles, has five longitudinal ridges on its carapace. These ridges are the most remarkable morphological features distinguished from other marine turtles. To investigate the hydrodynamic role of these ridges in the leatherback turtle swimming, we model a carapace with and without ridges by using three dimensional surface data of a stuffed leatherback turtle in the National Science Museum, Korea. The experiment is conducted in a wind tunnel in the ranges of the real leatherback turtle's Reynolds number (Re) and angle of attack (α). The longitudinal ridges function differently according to the flow condition (i.e. Re and α). At low Re and negative α that represent the swimming condition of hatchlings and juveniles, the ridges significantly decrease the drag by generating streamwise vortices and delaying the main separation. On the other hand, at high Re and positive α that represent the swimming condition of adults, the ridges suppress the laminar separation bubble near the front part by generating streamwise vortices and enhance the lift and lift-to-drag ratio. Supported by the NRF program (2011-0028032).

  5. Temporal and spatial distribution of Paleozoic metamorphism in the southern Appalachian Blue Ridge and Inner Piedmont delimited by ion microprobe U-Pb ages of metamorphic zircon

    USGS Publications Warehouse

    Merschat, Arthur J.; Bream, Brendan R.; Huebner, Matthew T.; Hatcher, Robert D.; Miller, Calvin F.

    2017-01-01

    Ion microprobe U-Pb zircon rim ages from 39 samples from across the accreted terranes of the central Blue Ridge, eastward across the Inner Piedmont, delimit the timing and spatial extent of superposed metamorphism in the southern Appalachian orogen. Metamorphic zircon rims are 10–40 µm wide, mostly unzoned, and dark gray to black or bright white in cathodoluminescence, and truncate and/or embay interior oscillatory zoning. Black unzoned and rounded or ovoid-shaped metamorphic zircon morphologies also occur. Th/U values range from 0.01 to 1.4, with the majority of ratios less than 0.1. Results of 206Pb/238U ages, ±2% discordant, range from 481 to 305 Ma. Clustering within these data reveals that the Blue Ridge and Inner Piedmont terranes were affected by three tectonothermal events: (1) 462–448 Ma (Taconic); (2) 395–340 Ma (Acadian and Neoacadian); and (3) 335–322 Ma, related to the early phase of the Alleghanian orogeny. By combining zircon rim ages with metamorphic isograds and other published isotopic ages, we identify the thermal architecture of the southern Appalachian orogen: juxtaposed and superposed metamorphic domains have younger ages to the east related to the marginward addition of terranes, and these domains can serve as a proxy to delimit terrane accretion. Most 462–448 Ma ages occur in the western and central Blue Ridge and define a continuous progression from greenschist to granulite facies that identifies the intact Taconic core. The extent of 462–448 Ma metamorphism indicates that the central Blue Ridge and Tugaloo terranes were accreted to the western Blue Ridge during the Taconic orogeny. Zircon rim ages in the Inner Piedmont span almost 100 m.y., with peaks at 395–385, 376–340, and 335–322 Ma, and delimit the Acadian-Neoacadian and Alleghanian metamorphic core. The timing and distribution of metamorphism in the Inner Piedmont are consistent with the Devonian to Mississippian oblique collision of the Carolina superterrane

  6. 76 FR 35909 - Temporary Concession Contract for Blue Ridge Parkway

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... Concession Contract for Blue Ridge Parkway AGENCY: National Park Service, Interior. ACTION: Notice of proposed award of temporary concession contracts for Blue Ridge Parkway, NC/VA. SUMMARY: Pursuant to 36 CFR... concession contracts for the conduct of certain visitor services within the Blue Ridge Parkway, North...

  7. Microbial Life in Ridge Flank Crustal Fluids at Baby Bare Seamount, Juan de Fuca Ridge

    NASA Astrophysics Data System (ADS)

    Huber, J. A.; Johnson, H. P.; Butterfield, D. A.; Baross, J. A.

    2005-12-01

    To determine the microbial community diversity within old oceanic crust, a novel sampling strategy was used to collect crustal fluids at Baby Bare Seamount, a 3.5 Ma old outcrop located in the northeast Pacific Ocean on the eastern flank of the Juan de Fuca Ridge. Stainless steel probes were driven directly into the igneous ocean crust to obtain samples of ridge flank crustal fluids. Genetic signatures and enrichment cultures of microorganisms demonstrate that these crustal fluids host a microbial community composed of species indigenous to the subseafloor, including anaerobic thermophiles, and species from other deep-sea habitats, such as seawater and sediments. Evidence using molecular techniques indicates the presence of a relatively small but active microbial population, dominated by bacteria. The microbial community diversity found in the crustal fluids may indicate habitat variability in old oceanic crust, with inputs of nutrients from seawater, sediment pore-water fluids and possibly hydrothermal sources. This report further supports the presence of an indigenous microbial community in ridge flank crustal fluids and advances our understanding of the potential physiological and phylogenetic diversity of this community.

  8. Deformation of the Western Caribbean: Insights from Block and Geodynamic Models of Geodetic, Seismic and Geologic Data

    NASA Astrophysics Data System (ADS)

    La Femina, P. C.; Geirsson, H.; Kobayashi, D.

    2012-12-01

    Cocos - Caribbean convergence along the Middle America Trench, including subduction of the Cocos Ridge and seamount domain, and Nazca - Caribbean oblique convergence along the South Panama Deformed Belt have resulted in complex plate boundary zone deformation since Miocene - Pliocene time. Plate boundary evolution and upper plate deformation in the western Caribbean is well studied and indicates, 1) Quaternary migration of the volcanic arc toward the back-arc northwest of the Cocos Ridge; 2) Pleistocene to present northwestward motion of the Central American Fore Arc (CAFA); 3) Quaternary to present deformation within the Central Costa Rica Deformed Belt; 4) Miocene-Pliocene cessation of volcanism and uplift of the Cordillera de Talamanca inboard the ridge; 5) Quaternary to present shortening across the fore-arc Fila Costeña fold and thrust belt and back-arc North Panama Deformed Belt (NPDB); 6) Quaternary to present outer fore-arc uplift above the seamount domain (Nicoya Peninsula), and above (Osa Peninsula) and flanking (Burica Peninsula) the ridge; and 7) Quaternary to present faulting along the Sona-Azuero and Canal Discontinuity fault systems. We investigate the dynamic effects of Cocos and Nazca convergence along the entire Central American margin, and the implications on western Caribbean plate boundary evolution with a new GPS derived three-dimensional (horizontal and vertical) velocity field and kinematic block and geodynamic models. Specifically, we test the hypotheses that the Cocos Ridge is the main driver for upper plate deformation and that there is an independent Panama block. Our model results provide new Euler vectors for the CAFA and Panama block, rates of relative plate and block motions in the region, and constraints on interseismic coupling along the Middle America Trench and other major block bounding fault systems. These results are compared to existing geophysical and geologic data for the region and add insights into the rates of

  9. Wrinkle Ridges and Pit Craters

    NASA Image and Video Library

    2016-10-19

    Tectonic stresses highly modified this area of Ganges Catena, north of Valles Marineris. The long, skinny ridges (called "wrinkle ridges") are evidence of compressional stresses in Mars' crust that created a crack (fault) where one side was pushed on top of the other side, also known as a thrust fault. As shown by cross-cutting relationships, however, extensional stresses have more recently pulled the crust of Mars apart in this region. (HiRISE imaged this area in 2-by-2 binning mode, so a pixel represents a 50 x 50 square centimeter.) http://photojournal.jpl.nasa.gov/catalog/PIA21112

  10. Reconstructing Holocene Summer Sea-Ice Conditions in the Central and Western Arctic Ocean: Morphological Variations and Stable Isotope Composition of Neogloboquadrina pachyderma

    NASA Astrophysics Data System (ADS)

    Asahi, H.; Nam, S. I.; Stein, R. H.; Mackensen, A.; Son, Y. J.

    2017-12-01

    The usability of planktic foraminiferal census data in Arctic paleoceanography is limited by the predominance of Neogloboquadrina pachyderma (sinistral). Though a potential usability of their morphological variation has been suggested by recent studies, its application is restricted to the central part of the Arctic Ocean. Here we present their regional distribution, using 80 surface sediment samples from the central and the western Arctic Ocean. Among seven morphological variations encountered, distinct presence of "large-sized" N. pachyderma morphotypes at the summer sea-ice edge in the western Arctic demonstrates its strong potential as sea-ice distribution indicator. Based on their regional patterns, we further developed planktic foraminifer (PF)-based transfer functions (TFs) to reconstruct summer surface-water temperature, salinity and sea-ice concentration in the western and central Arctic. The comparison of sea-ice reconstructions by PF-based TF to other pre-existed approaches showed their recognizable advantages/disadvantages: the PF-based approach in the nearby/within heavily ice-covered region, the dinocyst-based approach in the extensively seasonal ice retreat region, and the IP25-based approach with overall reflection over a wide range of sea-ice coverage, which is likely attributed to their (a) taphonomical information-loss, (b) different seasonal production patterns or combination of both. The application of these TFs on a sediment core from Northwind Ridge suggests general warming, freshening, and sea-ice reduction after 6.0 ka. This generally agrees with PF stable isotope records and sea-ice reconstructions from dinocyst-based TF at proximal locations, indicating that the sea-ice behavior at the Northwind Ridge is notably different from the IP25-based sea-ice reconstructions reported from elsewhere in the Arctic Ocean. Lack of regional coverage of PF-based reconstructions hampers further discussion whether the observed inconsistency is simply

  11. Phanerozoic stratigraphy of Northwind Ridge, magnetic anomalies in the Canada Basin, and the geometry and timing of rifting in the Amerasia Basin, Arctic Ocean

    USGS Publications Warehouse

    Grantz, A.; Clark, D.L.; Phillips, R.L.; Srivastava, S.P.; Blome, C.D.; Gray, L.-B.; Haga, H.; Mamet, B.L.; McIntyre, D.J.; McNeil, D.H.; Mickey, M.B.; Mullen, M.W.; Murchey, B.I.; Ross, C.A.; Stevens, C.H.; Silberling, Norman J.; Wall, J.H.; Willard, D.A.

    1998-01-01

    Cores from Northwind Ridge, a high-standing continental fragment in the Chukchi borderland of the oceanic Amerasia basin, Arctic Ocean, contain representatives of every Phanerozoic system except the Silurian and Devonian systems. Cambrian and Ordovician shallow-water marine carbonates in Northwind Ridge are similar to basement rocks beneath the Sverdrup basin of the Canadian Arctic Archipelago. Upper Mississippian(?) to Permian shelf carbonate and spicularite and Triassic turbidite and shelf lutite resemble coeval strata in the Sverdrup basin and the western Arctic Alaska basin (Hanna trough). These resemblances indicate that Triassic and older strata in southern Northwind Ridge were attached to both Arctic Canada and Arctic Alaska prior to the rifting that created the Amerasia basin. Late Jurassic marine lutite in Northwind Ridge was structurally isolated from coeval strata in the Sverdrup and Arctic Alaska basins by rift shoulder and grabens, and is interpreted to be a riftogenic deposit. This lutite may be the oldest deposit in the Canada basin. A cape of late Cenomanian or Turonian rhyodacite air-fall ash that lacks terrigenous material shows that Northwind Ridge was structurally isolated from the adjacent continental margins by earliest Late Cretaceous time. Closing Amerasia basin by conjoining seafloor magnetic anomalies beneath the Canada basin or by uniting the pre-Jurassic strata of Northwind Ridge with kindred sections in the Sverdrup basin and Hanna trough yield simular tectonic reconstructions. Together with the orientation and age of rift-marine structures, these data suggest that: 1) prior to opening of the Amerasia basin, both northern Alaska and continental ridges of the Chukchi borderland were part of North America, 2) the extension that created the Amerasia basin formed rift-margin graben beginning in Early Jurassic time and new oceanic crust probably beginning in Late Jurassic or early Neocomian time. Reconstruction of the Amerasia basin on the

  12. Mantle Convection beneath the Aegir Ridge, a Shadow in the Iceland Hotspot

    NASA Astrophysics Data System (ADS)

    Howell, S. M.; Ito, G.; Breivik, A. J.; Hanan, B. B.; Mjelde, R.; Sayit, K.; Vogt, P. R.

    2012-12-01

    The Iceland Hotspot has produced extensive volcanism spanning much of the ocean basin between Greenland and Norway, forming one of the world's largest igneous provinces. However, an apparent igneous "shadow" in hotspot activity is located at the fossil Aegir Ridge, which formed anomalously thin crust, despite this ridge being near the Iceland hotspot when it was active. The Aegir Ridge accommodated seafloor spreading northeast of present-day Iceland from the time of continental breakup at ~55 Ma until ~25 Ma, at which point spreading shifted west to the Kolbeinsey Ridge. To address the cause of the anomalously thin crust produced by the Aegir Ridge, we use three-dimensional numerical models to simulate the interaction between a mantle plume beneath the Iceland hotspot, rifting continental lithosphere, and the time-evolving North Atlantic ridge system. Two end-member hypotheses were investigated: (1) Material emanating from the Iceland mantle plume was blocked from reaching the Aegir Ridge by the thick lithosphere of the Jan Mayen Microcontinent as the Kolbeinsey Ridge began rifting it from Greenland at ~30 Ma, just east of the plume center; (2) Plume material was not blocked and did reach the Aegir Ridge, but had already experienced partial melting closer to the hotspot. This material was then unable to produce melt volumes at the Aegir Ridge comparable to those of pristine mantle. To test these hypotheses, we vary the volume flux and viscosity of the plume, and identify which conditions do and do not lead to the Aegir Ridge forming anomalously thin crust. Results show that the combination of plume material being drawn into the lithospheric channels beneath the Reykjanes Ridge and Kolbeinsey Ridge after their respective openings, and the impedance of plume flow by the Jan Mayen Microcontinent (hypothesis 1), can deprive the Aegir Ridge of plume influence. This leads to low crustal thicknesses that are comparable to those observed. We have yet to produce a model

  13. Cedar Ridge Camp: Using the Local Environment

    ERIC Educational Resources Information Center

    Burke, Grayson

    2007-01-01

    In 2007 Cedar Ridge Camp opened for its first season as a traditional co-ed summer camp and year-round outdoor education and recreation centre. The mission would centre on creating a program that would encourage personal development and growth through a shared outdoor experience. Cedar Ridge's main goals were to promote the formation of close…

  14. Tectonics of ridge-transform intersections at the Kane fracture zone

    NASA Astrophysics Data System (ADS)

    Karson, J. A.; Dick, H. J. B.

    1983-03-01

    The Kane Transform offsets spreading-center segments of the Mid-Atlantic Ridge by about 150 km at 24° N latitude. In terms of its first-order morphological, geological, and geophysical characteristics it appears to be typical of long-offset (>100 km), slow-slipping (2 cm yr-1) ridge-ridge transform faults. High-resolution geological observations were made from deep-towed ANGUS photographs and the manned submersible ALVIN at the ridge-transform intersections and indicate similar relationships in these two regions. These data indicate that over a distance of about 20 km as the spreading axes approach the fracture zone, the two flanks of each ridge axis behave in very different ways. Along the flanks that intersect the active transform zone the rift valley floor deepens and the surface expression of volcanism becomes increasingly narrow and eventually absent at the intersection where only a sediment-covered ‘nodal basin’ exists. The adjacent median valley walls have structural trends that are oblique to both the ridge and the transform and have as much as 4 km of relief. These are tectonically active regions that have only a thin (<200 m), highly fractured, and discontinuous carapace of volcanic rocks overlying a variably deformed and metamorphosed assemblage of gabbroic rocks. Overprinting relationships reveal a complex history of crustal extension and rapid vertical uplift. In contrast, the opposing flanks of the ridge axes, that intersect the non-transform zones appear to be similar in many respects to those examined elsewhere along slow-spreading ridges. In general, a near-axial horst and graben terrain floored by relatively young volcanics passes laterally into median valley walls with a simple block-faulted character where only volcanic rocks have been found. Along strike toward the fracture zone, the youngest volcanics form linear constructional volcanic ridges that transect the entire width of the fracture zone valley. These volcanics are continuous with

  15. Calendar year 1996 annual groundwater monitoring report for the Chestnut Ridge Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1997-02-01

    This annual monitoring report contains groundwater and surface water monitoring data obtained in the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime) during calendar year (CY) 1996. The Chestnut Ridge Regime encompasses a section of Chestnut Ridge west of Scarboro Road and east of an unnamed drainage feature southwest of the US Department of Energy (DOE) Oak Ridge Y-12 Plant (unless otherwise noted, directions are in reference to the Y-12 Plant administrative grid). The Chestnut Ridge Regime contains several sites used for management of hazardous and nonhazardous wastes associated with plant operations. Groundwater and surface water quality monitoring associated with thesemore » waste management sites is performed under the auspices of the Y-12 Plant Groundwater Protection Program (GWPP). Included in this annual monitoring report are the groundwater monitoring data obtained in compliance with the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit for the Chestnut Ridge Regime (post-closure permit) issued by the Tennessee Department of Environment and Conservation (TDEC) in June 1996. Besides the signed certification statement and the RCRA facility information summarized below, condition II.C.6 of the post-closure permit requires annual reporting of groundwater monitoring activities, inclusive of the analytical data and results of applicable data evaluations, performed at three RCRA hazardous waste treatment, storage, or disposal (TSD) units: the Chestnut Ridge Sediment Disposal Basin (Sediment Disposal Basin), the Chestnut Ridge Security Pits (Security Pits), and Kerr Hollow Quarry.« less

  16. Coupled ridge waveguide distributed feedback quantum cascade laser arrays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Ying-Hui; Zhang, Jin-Chuan, E-mail: zhangjinchuan@semi.ac.cn; Yan, Fang-Liang

    2015-04-06

    A coupled ridge waveguide quantum cascade laser (QCL) array consisting of fifteen elements with parallel integration was presented. In-phase fundamental mode operation in each element is secured by both the index-guided nature of the ridge and delicate loss management by properly designed geometries of the ridges and interspaces. Single-lobe lateral far-field with a nearly diffraction limited beam pattern was obtained. By incorporating a one-dimensional buried distributed feedback grating, the in-phase-operating coupled ridge waveguide QCL design provides an efficient solution to obtaining high output power and stable single longitudinal mode emission. The simplicity of this structure and fabrication process makes thismore » approach attractive to many practical applications.« less

  17. Wrinkle ridges, stress domains, and kinematics of venusian plains

    NASA Technical Reports Server (NTRS)

    Mcgill, George E.

    1993-01-01

    Wrinkle ridges are nearly ubiquitous landforms on the plains of Venus. By analogy with similar structures on other planets, venusian wrinkle ridges are inferred to trend normal to the direction of maximum principal compression in the crust, an inference that is verified by geometrical relationships with positive and negative relief features on Venus. Because plains are the dominant terrain on Venus, wrinkle ridges provide an excellent opportunity to determine the orientations of shallow crustal principal stress trajectories over most of the planet. In most places there are two or more sets of wrinkle ridges, and commonly one of these persists over a large area, defining a regional stress domain. Intersection relationships indicate that these domains differ in age.

  18. Europan double ridge morphometry as a test of formation models

    NASA Astrophysics Data System (ADS)

    Dameron, Ashley C.; Burr, Devon M.

    2018-05-01

    Double ridges on the Jovian satellite Europa consist of two parallel ridges with a central trough. Although these features are nearly ubiquitous on Europa, their formation mechanism(s) is (are) not yet well-understood. Previous hypotheses for their formation can be divided into two groups based on 1) the expected interior slope angles and 2) the magnitude of interior/exterior slope symmetry. The published hypotheses in the first ("fracture") group entail brittle deformation of the crust, either by diapirism, shear heating, or buckling due to compression. Because these mechanisms imply uplift of near-vertical fractures, their predicted interior slopes are steeper than the angle of repose (AOR) with shallower exterior slopes. The second ("flow") group includes cryosedimentary and cryovolcanic processes - explosive or effusive cryovolcanism and tidal squeezing -, which are predicted to form ridge slopes at or below the AOR. Explosive cryovolcanism would form self-symmetric ridges, whereas effusive cryolavas and cryo-sediments deposited during tidal squeezing would likely not exhibit slope symmetry. To distinguish between these two groups of hypothesized formation mechanisms, we derived measurements of interior slope angle and interior/exterior slope symmetry at multiple locations on Europa through analysis of data from the Galileo Solid State Imaging (SSI) camera. Two types of data were used: i) elevation data from five stereo-pair digital elevation models (DEMs) covering four ridges (580 individual measurements), and ii) ridge shadow length measurements taken on individual images over 40 ridges (200 individual measurements). Our results shows that slopes measured on our DEMs, located in the Cilix and Banded Plains regions, typically fall below the AOR, and slope symmetry is dominant. Two different shadow measurement techniques implemented to calculate interior slopes yielded slope angles that also fall below the AOR. The shallow interior slopes derived from both

  19. Connections between the tropical Pacific Ocean, Arctic sea ice, and anomalous northeastern Pacific ridging

    NASA Astrophysics Data System (ADS)

    Swain, D. L.; Singh, D.; Horton, D. E.; Mankin, J. S.; Ballard, T.; Thomas, L. N.; Diffenbaugh, N. S.

    2016-12-01

    The ongoing and severe drought in California is linked to the multi-year persistence of anomalously strong ridging along the west coast of North America, which has deflected the Pacific storm track north of its climatological mean position. Recent work has shown that that highly amplified and strongly meridional atmospheric flow patterns in this region similar to the "Ridiculously Resilient Ridge" have become more common in recent decades. Previous investigations have suggested multiple possible contributors to this conspicuous atmospheric anomaly—including remote teleconnections to unusual tropical Pacific Ocean warmth and/or reduced Arctic sea ice, internal (natural) atmospheric variability, and anthropogenic forcing due to greenhouse gas emissions. Here, we explore observed relationships between mid-tropospheric atmospheric structure in this region and five hypothesized surface forcings: sea ice extent in the (1) Barents/Kara and (2) Beaufort/Chukchi regions, and sea surface temperatures in the (3) extratropical northeastern Pacific Ocean, (4) western tropical Pacific Ocean, and (5) eastern tropical Pacific Ocean. Using a predictive model based upon these observed relationships, we also investigate whether the failure of the powerful 2015-2016 El Niño event to bring above-average precipitation to California could have been predicted based upon these teleconnections.

  20. Enhanced dust emissivity power-law index along the western H α filament of NGC 1569

    NASA Astrophysics Data System (ADS)

    Suzuki, T.; Kaneda, H.; Onaka, T.; Yamagishi, M.; Ishihara, D.; Kokusho, T.; Tsuchikawa, T.

    2018-07-01

    We used a data set from AKARI and Herschel images at wavelengths from 7 to 500 μm to catch the evidence of dust processing in galactic winds in NGC 1569. Images show a diffuse infrared (IR) emission extending from the galactic disc into the halo region. The most prominent filamentary structure seen in the diffuse IR emission is spatially in good agreement with the western H α filament (western arm). The spatial distribution of the F350/F500 map shows high values in regions around the super-star clusters (SSCs) and towards the western arm, which are not found in the F250/F350 map. The colour-colour diagram of F250/F350-F350/F500 indicates high values of the emissivity power-law index (βc) of the cold dust component in those regions. From a spectral decomposition analysis on a pixel-by-pixel basis, a βc map shows values ranging from ˜1 to ˜2 over the whole galaxy. In particular, high βc values of ˜2 are observed only in the regions indicated by the colour-colour diagram. Since the average cold dust temperature in NGC 1569 is ˜30 K, βc < 2.0 in the far-IR and sub-mm region theoretically suggests emission from amorphous grains, while βc = 2.0 suggests that from crystal grains. Given that the enhanced βc regions are spatially confined by the H I ridge that is considered to be a birthplace of the SSCs, the spatial coincidences may indicate that dust grains around the SSCs are grains of relatively high crystallinity injected by massive stars originating from starburst activities and that those grains are blown away along the H I ridge and thus the western arm.

  1. Drought in the northern Bahamas from 3300 to 2500 years ago

    NASA Astrophysics Data System (ADS)

    van Hengstum, Peter J.; Maale, Gerhard; Donnelly, Jeffrey P.; Albury, Nancy A.; Onac, Bogdan P.; Sullivan, Richard M.; Winkler, Tyler S.; Tamalavage, Anne E.; MacDonald, Dana

    2018-04-01

    Intensification and western displacement of the North Atlantic Subtropical High (NASH) is projected for this century, which can decrease Caribbean and southeastern American rainfall on seasonal and annual timescales. However, additional hydroclimate records are needed from the northern Caribbean to understand the long-term behavior of the NASH, and better forecast its future behavior. Here we present a multi-proxy sinkhole lake reconstruction from a carbonate island that is proximal to the NASH (Abaco Island, The Bahamas). The reconstruction indicates the northern Bahamas experienced a drought from ∼3300 to ∼2500 Cal yrs BP, which coincides with evidence from other hydroclimate and oceanographic records (e.g., Africa, Caribbean, and South America) for a synchronous southern displacement of the Intertropical Convergence Zone and North Atlantic Hadley Cell. The specific cause of the hydroclimate change in the northeastern Caribbean region from ∼3300 to 2500 Cal yrs BP was probably coeval southern or western displacement of the NASH, which would have increased northeastern Caribbean exposure to subsiding air from higher altitudes.

  2. The Mid-Ocean Ridge.

    ERIC Educational Resources Information Center

    Macdonald, Kenneth C.; Fox, Paul J.

    1990-01-01

    Described are concepts involved with the formation and actions of the Mid-Ocean Ridge. Sea-floor spreading, the magma supply model, discontinuities, off-axis structures, overlaps and deviation, and aquatic life are discussed. (CW)

  3. Banded Ridges in Hellas

    NASA Image and Video Library

    2014-01-09

    Low lying areas in the Hellas region, which is the largest impact basin on Mars, often show complex groups of banded ridges, furrows, and pits as seen in this observation from NASA Mars Reconnaissance Orbiter.

  4. The Central Symmetry Analysis of Wrinkle Ridges in Lunar Mare Serenitatis

    NASA Astrophysics Data System (ADS)

    Yao, Meijuan; Chen, Jianping

    2018-03-01

    Wrinkle ridges are one of the most common structures usually found in lunar mare basalts, and their formations are closely related to the lunar mare. In this paper, wrinkle ridges in Mare Serenitatis were identified and mapped via high-resolution data acquired from SELENE, and a quantitative method was introduced to analyze the degree of central symmetry of the wrinkle ridges distributed in a concentric or radial pattern. Meanwhile, two methods were used to measure the lengths and orientations of wrinkle ridges before calculating their central symmetry value. Based on the mapped wrinkle ridges, we calculated the central symmetry value of the wrinkle ridges for the whole Mare Serenitatis as well as for the four circular ridge systems proposed by a previous study via this method. We also analyzed the factors that would cause discrepancies when calculating the central symmetry value. The results indicate that the method can be used to quantitatively analyze the degree of central symmetry of the linear features that were concentrically or radially oriented and can reflect the stress field characteristics.

  5. Maxillary anterior ridge augmentation with recombinant human bone morphogenetic protein 2.

    PubMed

    Edmunds, Ryan K; Mealey, Brian L; Mills, Michael P; Thoma, Daniel S; Schoolfield, John; Cochran, David L; Mellonig, Jim

    2014-01-01

    No human studies exist on the use of recombinant human bone morphogenetic protein 2 (rhBMP-2) on an absorbable collagen sponge (ACS) as a sole graft material for lateral ridge augmentation in large ridge defect sites. This series evaluates the treatment outcome of maxillary anterior lateral ridge augmentation with rhBMP-2/ACS. Twenty patients were treated with rhBMP-2/ACS and fixation screws for space maintenance. Cone beam volumetric tomography measurements were used to determine gain in ridge width, and a bone core biopsy was obtained. The mean horizontal ridge gain was 1.2 mm across sites, and every site gained width.

  6. Unfaulting the Sardarapat Ridge, Southwest Armenia

    NASA Astrophysics Data System (ADS)

    Wetmore, P.; Connor, C.; Connor, L. J.; Savov, I. P.; Karakhanyan, A.

    2012-12-01

    Armenia is located near the core of contractional deformation associated with the collision between the Arabian and Eurasian tectonic plates. Several studies of this region, including portions of adjacent Georgia, Iran, and Turkey, have indicated that 1-2 mm/yr of intra-plate, north-south shortening is primarily accommodated by a network of E-W trending thrust faults, and NW-trending (dextral) and NE-trending (sinistral) strike-slip faults. One proposed fault in this network, the Sardarapat Fault (SF), was investigated as part of a regional seismic hazard assessment ahead of the installation of a replacement reactor at the Armenian Nuclear Power Plant (ANPP). The SF is primarily defined by the Sardarapat Ridge (SR), which is a WNW-trending, 40-70 m high topographic feature located just north of the Arax River and the Turkey-Armenia border. The stratigraphy comprising this ridge includes alluvium overlying several meters of lacustrine deposits above a crystal-rich basaltic lava flow that yields an Ar-Ar age of 0.9 +/- 0.02 Ma. The alluvial sediments on the ridge contain early Bronze age (3832-3470 BP) artifacts at an elevation 25 m above those of the surrounding alluvial plane. This has lead to the suggestion that the SR is bound to the south (the steepest side) by the SF, which is uplifting the ridge at a rate of 0.7 mm/yr. However, despite the prominence and trend of the ridge there are no unequivocal observations, such as scarps or exposures of fault rocks, to support the existence of the SF. The goal of the investigation of the SR area was to test various models for the formation of the ridge including faulting and combined volcanic and erosional processes. We therefore collected gravimetric, magnetic, magneto-tellurics (MT), and transient electromagnetic (TEM) data across an area of ~400 km2, and used correlations of stratigraphic data from coreholes drilled proximal to the study area to define the geometry of the contact between the basement and basin fill to

  7. Ridges on Europa: Origin by Incremental Ice-Wedging

    NASA Technical Reports Server (NTRS)

    Melosh, H. J.; Turtle, E. P.

    2004-01-01

    The surface of Europa is covered by ridges that display a variety of morphologies . The most common type is characterized by a double ridge divided by an axial trough. These ridges are, in general, narrow (typically only a few km across) and remarkably linear. They are up to a few hundred meters high and the inner and outer slopes appear to stand at the angle of repose . A number of diverse mechanisms have been proposed to explain the formation of these ubiquitous features , although none can fully account for all of their observed characteristics. We propose a different formation theory in which accumulation of material within cracks that open during the extensional phase of the tidal cycle prevents complete closure of the cracks during the tidal cycle s compressional phase. This accumulation deforms the surrounding ice and, in time, results in the growth of a landform remarkably similar to the ridges observed on Europa.

  8. Martian Ridge Looming Above Curiosity Prior to Ascent

    NASA Image and Video Library

    2017-09-13

    Researchers used the Mast Camera (Mastcam) on NASA's Curiosity Mars rover to gain this detailed view of layers in "Vera Rubin Ridge" from just below the ridge. The scene combines 70 images taken with the Mastcam's right-eye, telephoto-lens camera, on Aug. 13, 2017, during the 1,785th Martian day, or sol, of Curiosity's work on Mars. This and other Mastcam panoramas show details of the sedimentary rocks that make up the "Vera Rubin Ridge." This distinct topographic feature located on the lower slopes of Mount Sharp (Aeolis Mons) is characterized by the presence of hematite, an iron-oxide mineral, which has been detected from orbit. The Mastcam images show that the rocks making up the lower part of the ridge are characterized by distinct horizontal stratification with individual rock layers of the order of several inches (tens of centimeters) thick. Scientists on the mission are using such images to determine the ancient environment these rocks were deposited in. The repeated beds indicate progressive accumulation of sediments that now make up the lower part of Mount Sharp, although from this distance it is not possible to know if they were formed by aqueous or wind-blown processes. Close-up images collected as the rover climbs the ridge will help answer this question. The stratified rocks are cross cut by veins filled with a white mineral, likely calcium sulfate, that provide evidence of later episodes of fluid flow through the rocks. The panorama has been white-balanced so that the colors of the rock materials resemble how they would appear under daytime lighting conditions on Earth. It spans from southeast on the left to west on the right. The Sol 1785 location just north of the ridge is shown in a Sol 1782 traverse map. The ridge was informally named in early 2017 in memory of Vera Cooper Rubin (1928-2016), whose astronomical observations provided evidence for the existence of the universe's dark matter. An annotated figure is shown at https

  9. Evidence for lateral mantle plume flow feeding the Central Indian Ridge

    NASA Astrophysics Data System (ADS)

    Murton, B. J.; Tindle, A. G.

    2003-04-01

    The Central Indian Ridge exhibits morphological and geochemical features indicating lateral flow of shallow plume asthenosphere from the Reunion hot-spot to the ridge axis. South of the Marie Celeste fracture zone, at 18.25°S, the Central Indian Ridge is bound by a southward closing, “V”-shaped region of shallow crust that extends for over 800 km. Over this distance, the ridge axis deepens to the south and is also affected by left-stepping offsets that bring it towards the west. The northern end of the ridge, which is closest to the island of La'Réunion, is shallowest and dominated by an inflated segment with associated sheet flows covering over 50 square kilometres. These morphological features are usually associated with ridge-hot-spot interaction. However, the nearest active hot-spot lies over 1100 km to the west beneath the island of La'Réunion. Geochemical trends for basalts erupted along the Central Indian Ridge demonstrate a gradient of northward decreasing MgO and increasing SiO2, indicating a relationship between shallower crust and increased magmatic fractional crystallisation. Superimposed on this gradient is an excess increase in incompatible element ratios, indicative of mantle enrichment to the north. The enrichment correlates with the spreading-parallel distance between the ridge axis and the edge of the "V"-shaped region of anomalously shallow crust. Locally, the enriched mantle component is found preferentially at third-order ridge offsets and adjacent to the rift walls demonstrating melting of a compositionally stratified, spinel-lherzolite mantle. These features are evidence for shallow, lateral flow of enriched hot-spot asthenosphere at a velocity of ~333 mm yr-1 and with a flux of at least 50 m3 s-1, through a mantle 'worm', towards the ridge axis where it migrates south at a rate of 54 - 67 mm per year. The trend of the geochemical enrichment points to mixing between deeper N-MORB and shallower Reunion hot-spot sources beneath the

  10. A V-band wafer probe using ridge-trough waveguide

    NASA Astrophysics Data System (ADS)

    Godshalk, Edward M.

    1991-12-01

    A V-band (50-75 GHz) wafer probe is presented. The probe features a type of waveguide developed to allow transition from rectangular waveguide to coplanar waveguide. The waveguide consists of a ridge extending from the upper waveguide wall into a trough in the lower waveguide wall, and is known as the ridge-trough waveguide. A mathematical model is presented that allows important properties of the ridge-trough waveguide, such as the cutoff frequency and characteristic impedance, to be calculated.

  11. Sinuous Ridge on the Orson Welles Bajada

    NASA Image and Video Library

    2015-04-22

    Alluvial fans are piles of debris dumped by rivers when they emerge from the mountains and enter a mostly dry valley as seen by NASA Mars Reconnaissance Orbiter. A bajada (such as this example named after the famous American filmmaker) consists of a series of coalescing alluvial fans along a mountain front. On the surface of this bajada, one can see many sinuous ridges. These ridges mark the path that streams of water took as they flowed into this crater. The sinuosity of the ridges tells us something about the speed of the water flow. Fast moving flows tend to be straighter than slow-moving. Observations like this help us build a picture of how rivers behaved on ancient Mars. http://photojournal.jpl.nasa.gov/catalog/PIA19366

  12. Reading Ombrone river delta evolution through beach ridges morphology

    NASA Astrophysics Data System (ADS)

    Mammi, Irene; Piccardi, Marco; Pranzini, Enzo; Rossi, Lorenzo

    2017-04-01

    The present study focuses on the evolution of the Ombrone River delta (Southern Tuscany, Italy) in the last five centuries, when fluvial sediment input was huge also as a consequence of the deforestation performed on the watershed. The aim of this study is to find a correlation between river input and beach ridges morphology and to explain the different distribution of wetlands and sand deposits on the two sides of the delta. Visible, NIR and TIR satellite images were processed to retrieve soil wetness associated to sand ridges and interdune silty deposits. High resolution LiDAR data were analysed using vegetation filter and GIS enhancement algorithms in order to highlight small morphological variations, especially in areas closer to the river where agriculture has almost deleted these morphologies. A topographic survey and a very high resolution 3D model obtained from a set of images acquired by an Unmanned Aerial Vehicle (UAV) were carried out in selected sites, both to calibrate satellite LiDAR 3D data, and to map low relief areas. Historical maps, aerial photography and written documents were analysed for dating ancient shorelines associated to specific beach ridges. Thus allowing the reconstruction of erosive and accretive phases of the delta. Seventy beach ridges were identified on the two wings of the delta. On the longer down-drift side (Northern wing) beach ridges are more spaced at the apex and gradually converge to the extremity, where the Bruna River runs and delimits the sub aerial depositional area of the Ombrone River. On the shorter up-drift lobe (Southern wing), beach ridges are closer, but run almost parallel each other. In this case, a rocky headland called Collelungo promontory closes and cuts the beach ridges sequence but shallow water depth allows sediment by pass. One kilometre to the south a more pronounced promontory encloses a small pocket beach (Cala di Forno) and identifies the limit of the subaerial depositionary area. Beach ridges

  13. Continental Affinities of the Alpha Ridge

    NASA Astrophysics Data System (ADS)

    Jackson, H. Ruth; Li, Qingmou; Shimeld, John; Chian, Deping

    2017-04-01

    Identifying the crustal attributes of the Alpha Ridge (AR) part of the High Arctic Large Igneous Province and tracing the spreading centre across the Amerasia Basin plays a key role in understanding the opening history of the Arctic Ocean. In this approach, we report the evidence for a continental influence on the development of the AR and reduced ocean crust in the Amerasia Basin. These points are inferred from a documented continental sedimentation source in the Amerasia Basin and calculated diagnostic compressional and shear refraction waves, and from the tracing of the distinct spreading centre using the potential field data. (1) The circum-Arctic geology of the small polar ocean provides compelling evidence of a long-lived continental landmass north of the Sverdrup Basin in the Canadian Arctic Islands and north of the Barents Sea continental margin. Based on sediment distribution patterns in the Sverdrup Basin a continental source is required from the Triassic to mid Jurassic. In addition, an extensive continental sediment source to the north of the Barents Sea is required until the Barremian. (2) Offshore data suggest a portion of continental crust in the Alpha and Mendeleev ridges including measured shear wave velocities, similarity of compressional wave velocities with large igneous province with continental fragments and magnetic patterns. Ocean bottom seismometers recorded shear waves velocities that are sensitive to the quartz content of rocks across the Chukchi Borderland and the Mendeleev Ridge that are diagnostic of both an upper and lower continental crust. On the Nautilus Spur of the Alpha Ridge expendable sonobuoys recorded clear converted shear waves also consistent with continental crust. The magnetic patterns (amplitude, frequency, and textures) on the Northwind Ridge and the Nautilus Spur also have similarities. In fact only limited portions of the deepest water portions of the Canada Basin and the Makarov Basin have typical oceanic layer 2 and

  14. CUTIN SYNTHASE 2 Maintains Progressively Developing Cuticular Ridges in Arabidopsis Sepals.

    PubMed

    Hong, Lilan; Brown, Joel; Segerson, Nicholas A; Rose, Jocelyn K C; Roeder, Adrienne H K

    2017-04-03

    The cuticle is a crucial barrier on the aerial surfaces of land plants. In many plants, including Arabidopsis, the sepals and petals form distinctive nanoridges in their cuticles. However, little is known about how the formation and maintenance of these nanostructures is coordinated with the growth and development of the underlying cells. Here we report the characterization of the Arabidopsis cutin synthase 2 (cus2) mutant, which causes a great reduction in cuticular ridges on the mature sepal epidermis, but only a moderate effect on petal cone cell ridges. Using scanning electron microscopy and confocal live imaging combined with quantification of cellular growth, we find that cuticular ridge formation progresses down the sepal from tip to base as the sepal grows. pCUS2::GFP-GUS reporter expression coincides with cuticular ridge formation, descending the sepal from tip to base. Ridge formation also coincides with the reduction in growth rate and termination of cell division of the underlying epidermal cells. Surprisingly, cuticular ridges at first form normally in the cus2 mutant, but are lost progressively at later stages of sepal development, indicating that CUS2 is crucial for the maintenance of cuticular ridges after they are formed. Our results reveal the dynamics of both ridge formation and maintenance as the sepal grows. Copyright © 2017 The Author. Published by Elsevier Inc. All rights reserved.

  15. Steps in the intensification of Benguela upwelling over the Walvis Ridge during Miocene and Pliocene

    NASA Astrophysics Data System (ADS)

    Hoetzel, Sebastian; Dupont, Lydie M.; Marret, Fabienne; Jung, Gerlinde; Wefer, Gerold

    2017-01-01

    Upwelling is a significant part of the ocean circulation controlling largely the transport of nutrient-rich cold waters to the surface and therefore influencing ocean productivity and global climate. The Benguela upwelling system (BUS) is one of the major upwelling areas in the world. Previous reconstructions of the BUS mainly focused on the onset and intensification in southern and central parts, but changes of the northern part have been rarely investigated in detail. Using the Late Miocene to Pliocene organic-walled dinoflagellate cyst record of ODP Site 1081, we reconstruct and discuss the early upwelling history over the Walvis Ridge with a special focus on the movement of the Angola-Benguela Front (ABF). We suggest that during the Late Miocene the Angola Current flowed southwards over the Walvis Ridge more frequently than today because the ABF was probably located further south as a result of a weaker meridional temperature gradient. A possible strengthening of the meridional gradient during the latest Miocene to early Pliocene in combination with uplift of south-western Africa intensified the upwelling along the coast and increased the upwelling's filaments over the Walvis Ridge. An intermediate period from 6.2 to 5.5 Ma is shown by the dominance of Habibacysta tectata, cysts of a cool-tolerant dinoflagellate known from the northern Atlantic, indicating changing oceanic conditions contemporaneous with the Messinian Salinity Crisis. From 4.3 Ma on, the upwelling signal got stronger again and waters were well-mixed and nutrient-rich. Our results indicate a northward migration of the ABF as early as 7 Ma and the initial stepwise intensification of the BUS.

  16. Transitions in axial morphology along the Southeast Indian Ridge

    NASA Astrophysics Data System (ADS)

    Ma, Ying; Cochran, James R.

    1996-07-01

    Shipboard bathymetric and magnetic profiles across the Southeast Indian Ridge (SEIR) were analyzed in order to examine the nature of along-axis variations in axial morphology at this intermediate spreading rate ridge. Three types of axial morphology are observed along the SEIR: an axial high, a shallow (200-700 m deep) axial valley and a deep (>1000 m deep) axial valley. An axial high is found to the east of the Australian-Antarctic Discordance (AAD) (east of 128°E) and between 82°E and 104°E. A shallow rift valley is found from 104°E to 114°E and from 82°E westward past the Amerstdam/St. Paul hotspot (ASP) to about 30°S, 75°E. Deep rift valleys are found from 114°E to 128°E in the vicinity of the AAD and from the Indian Ocean Triple Junction (IOTJ) at 25°S, 70°E to about 30°S, 75°E. The transition near 30°S occurs in an area of constant zero-age depth and does not appear to result from an increase in mantle temperature. It could be the result of the rapid increase in spreading rate along that portion of the SEIR. The most likely cause of the other transitions in axial morphology is variations in mantle temperature. The transitions between the different types of axial morphology are well defined and occur over a limited distance. Transitions in axial morphology are accompanied by significant changes in ridge flank topographic roughness. The transitions from axial valleys to axial highs are also accompanied by changes in the amplitude of the seafloor magnetic anomalies. Our observations suggest that there are distinct modes rather than a continuum of axial morphology on the SEIR and that there appears to be a "threshold" mechanism for a rapid change between different states of axial morphology. The ASP has only a limited influence on the SEIR. The ridge axis is marked by an axial valley for the entire distance from the IOTJ up to and past the ASP. The ridge axis becomes shallower as the ASP is approached from the northwest but only by about 300 m over

  17. Alveolar Ridge Split Technique Using Piezosurgery with Specially Designed Tips

    PubMed Central

    Moro, Alessandro; Foresta, Enrico; Falchi, Marco; De Angelis, Paolo; D'Amato, Giuseppe; Pelo, Sandro

    2017-01-01

    The treatment of patients with atrophic ridge who need prosthetic rehabilitation is a common problem in oral and maxillofacial surgery. Among the various techniques introduced for the expansion of alveolar ridges with a horizontal bone deficit is the alveolar ridge split technique. The aim of this article is to give a description of some new tips that have been specifically designed for the treatment of atrophic ridges with transversal bone deficit. A two-step piezosurgical split technique is also described, based on specific osteotomies of the vestibular cortex and the use of a mandibular ramus graft as interpositional graft. A total of 15 patients were treated with the proposed new tips by our department. All the expanded areas were successful in providing an adequate width and height to insert implants according to the prosthetic plan and the proposed tips allowed obtaining the most from the alveolar ridge split technique and piezosurgery. These tips have made alveolar ridge split technique simple, safe, and effective for the treatment of horizontal and vertical bone defects. Furthermore the proposed piezosurgical split technique allows obtaining horizontal and vertical bone augmentation. PMID:28246596

  18. Constrained circulation at Endeavour ridge facilitates colonization by vent larvae.

    PubMed

    Thomson, Richard E; Mihály, Steven F; Rabinovich, Alexander B; McDuff, Russell E; Veirs, Scott R; Stahr, Frederick R

    2003-07-31

    Understanding how larvae from extant hydrothermal vent fields colonize neighbouring regions of the mid-ocean ridge system remains a major challenge in oceanic research. Among the factors considered important in the recruitment of deep-sea larvae are metabolic lifespan, the connectivity of the seafloor topography, and the characteristics of the currents. Here we use current velocity measurements from Endeavour ridge to examine the role of topographically constrained circulation on larval transport along-ridge. We show that the dominant tidal and wind-generated currents in the region are strongly attenuated within the rift valley that splits the ridge crest, and that hydrothermal plumes rising from vent fields in the valley drive a steady near-bottom inflow within the valley. Extrapolation of these findings suggests that the suppression of oscillatory currents within rift valleys of mid-ocean ridges shields larvae from cross-axis dispersal into the inhospitable deep ocean. This effect, augmented by plume-driven circulation within rift valleys having active hydrothermal venting, helps retain larvae near their source. Larvae are then exported preferentially down-ridge during regional flow events that intermittently over-ride the currents within the valley.

  19. Accretion mode of oceanic ridges governed by axial mechanical strength

    NASA Astrophysics Data System (ADS)

    Sibrant, A. L. R.; Mittelstaedt, E.; Davaille, A.; Pauchard, L.; Aubertin, A.; Auffray, L.; Pidoux, R.

    2018-04-01

    Oceanic spreading ridges exhibit structural changes as a function of spreading rate, mantle temperature and the balance of tectonic and magmatic accretion. The role that these or other processes have in governing the overall shape of oceanic ridges is unclear. Here, we use laboratory experiments to simulate ridge spreading in colloidal aqueous dispersions whose rheology evolves from purely viscous to elastic and brittle when placed in contact with a saline water solution. We find that ridge shape becomes increasingly linear with spreading rate until reaching a minimum tortuosity. This behaviour is predicted by the axial failure parameter ΠF, a dimensionless number describing the balance of brittle and plastic failure of axial lithosphere. Slow-spreading, fault-dominated and fast-spreading, fluid intrusion-dominated ridges on Earth and in the laboratory are separated by the same critical ΠF value, suggesting that the axial failure mode governs ridge geometry. Values of ΠF can also be calculated for different mantle temperatures and applied to other planets or the early Earth. For higher mantle temperatures during the Archaean, our results preclude the predicted formation of large tectonic plates at high spreading velocity.

  20. Alveolar Ridge Split Technique Using Piezosurgery with Specially Designed Tips.

    PubMed

    Moro, Alessandro; Gasparini, Giulio; Foresta, Enrico; Saponaro, Gianmarco; Falchi, Marco; Cardarelli, Lorenzo; De Angelis, Paolo; Forcione, Mario; Garagiola, Umberto; D'Amato, Giuseppe; Pelo, Sandro

    2017-01-01

    The treatment of patients with atrophic ridge who need prosthetic rehabilitation is a common problem in oral and maxillofacial surgery. Among the various techniques introduced for the expansion of alveolar ridges with a horizontal bone deficit is the alveolar ridge split technique. The aim of this article is to give a description of some new tips that have been specifically designed for the treatment of atrophic ridges with transversal bone deficit. A two-step piezosurgical split technique is also described, based on specific osteotomies of the vestibular cortex and the use of a mandibular ramus graft as interpositional graft. A total of 15 patients were treated with the proposed new tips by our department. All the expanded areas were successful in providing an adequate width and height to insert implants according to the prosthetic plan and the proposed tips allowed obtaining the most from the alveolar ridge split technique and piezosurgery. These tips have made alveolar ridge split technique simple, safe, and effective for the treatment of horizontal and vertical bone defects. Furthermore the proposed piezosurgical split technique allows obtaining horizontal and vertical bone augmentation.

  1. Tectonic evolution of Gorda Ridge inferred from sidescan sonar images

    USGS Publications Warehouse

    Masson, D.G.; Cacchione, D.A.; Drake, D.E.

    1988-01-01

    Gorda Ridge is the southern segment of the Juan de Fuca Ridge complex, in the north-east Pacific. Along-strike spreading-rate variation on Gorda Ridge and deformation of Gorda Plate are evidence for compression between the Pacific and Gorda Plates. GLORIA sidescan sonographs allow the spreading fabric associated with Gorda Ridge to be mapped in detail. Between 5 and 2 Ma, a pair of propagating rifts re-orientated the northern segment of Gorda Ridge by about 10?? clockwise, accommodating a clockwise shift in Pacific-Juan de Fuca plate motion that occurred around 5 Ma. Deformation of Gorda Plate, associated with southward decreasing spreading rates along southern Gorda Ridge, is accommodated by a combination of clockwise rotation of Gorda Plate crust, coupled with left-lateral motion on the original normal faults of the ocean crust. Segments of Gorda Plate which have rotated by different amounts are separated by narrow deformation zones across which sharp changes in ocean fabric trend are seen. Although minor lateral movement may occur on these NW to WNW structures, no major right-lateral movement, as predicted by previous models, is observed. ?? 1988 Kluwer Academic Publishers.

  2. Zinc, copper, and lead in mid-ocean ridge basalts and the source rock control on Zn/Pb in ocean-ridge hydrothermal deposits

    USGS Publications Warehouse

    Doe, B.R.

    1994-01-01

    The contents of Zn, Cu, and Pb in mid-ocean ridge basalts (MORB) and the MORB source-rock control on Zn/Pb in ocean-ridge hydrothermal deposits are examined. The values of Zn, Cu, and Pb for submarine mid-ocean ridge basalts (MORB) are, respectively (in ppm): average MORB-75, 75, and 0.7; West Valley, Juan de Fuca Ridge (JFR)-87, 64, and 0.5; southern JFR-120 and 0.5; and 21??N, East Pacific Rise (EPR)-73, 78, and 0.5. Values of Zn/Pb range from about 100-240 and Cu/ Pb from 100-156. In this study, Zn is found to correlate positively with TiO2 + FeO (mean square of weighted deviates, MSWD, of 1.6 for JFR basalt), and inversely with Mg number (MSWD of 3.5). Therefore, contrary to statements in the literature that Zn should be compatible in MORB, Zn is a mildly incompatible element and must be enriched in the glass phase relative to olivine as Zn does not fit into the other major phenocryst phase, plagioclase. In the source of MORB, Zn likely is most enriched in oxides: spinel, magnetite, and titanomagnetite. Copper generally does not correlate well with other elements in most MORB data examined. When differentiation is dominated by olivine, Cu has a tendency to behave incompatibly (e.g., at Mg numbers > 70), but, overall, Cu shows some tendency towards being a compatible element, particularly along the Mid-Atlantic Ridge, a behavior presumably due to separation of sulfides in which Cu (but not Zn) is markedly enriched. Copper thus may be in dispersed sulfides in the source of MORB. Ocean ridges provide important data on source-rock controls for sulfide deposits because, in sediment-starved ridges, much is known about the possible source rocks and mineralization is presently occurring. In contrast to Zn/Pb ~5 in continental hot Cl-rich brines, Zn/Pb in the hottest sediment-starved ridge black smoker hydrothermal fluids at 21 ??N, EPR is about 110, similar to local MORB (145), but Cu/Pb is closer to 30, possibly due to subsurface deposition of Cu. At the JFR, the best

  3. Strong signatures of high-latitude blocks and subtropical ridges in winter PM10 over Europe

    NASA Astrophysics Data System (ADS)

    Ordonez, C.; Garrido-Perez, J. M.; Garcia-Herrera, R.

    2017-12-01

    Atmospheric blocking is associated with persistent, slow-moving high pressure systems that interrupt the eastward progress of extratropical storm systems at middle and high latitudes. Subtropical ridges are low latitude structures manifested as bands of positive geopotential height anomalies extending from sub-tropical latitudes towards extra-tropical regions. We have quantified the impact of blocks and ridges on daily PM10 (particulate matter ≤ 10 µm) observations obtained from the European Environment Agency's air quality database (AirBase) for the winter period of 2000-2010. For this purpose, the response of the PM10 concentrations to the location of blocks and ridges with centres in two main longitudinal sectors (Atlantic, ATL, 30˚-0˚ W; European, EUR, 0˚-30˚ E) is examined. EUR blocking is associated with a collapse of the boundary layer as well as reduced wind speeds and precipitation occurrence, yielding large positive anomalies which average 12 µg m-3 over the whole continent. Conversely, the enhanced zonal flow around 50˚-60˚ N and the increased occurrence of precipitation over northern-central Europe on days with ATL ridges favour the ventilation of the boundary layer and the impact of washout processes, reducing PM10 concentrations on average by around 8 µg m-3. The presence of EUR blocks is also concurrent with an increased probability of exceeding the European air quality target (50 µg m-3 for 24-h averaged PM10) and the local 90th percentiles for this pollutant at many sites, while the opposite effect is found for ridges. In addition, the effect of synoptic persistence on the PM10 concentrations is particularly strong for EUR blocks. Finally, we have found that the effect of both synoptic patterns can partly control the interannual variability of winter mean PM10 at many sites of north-western and central Europe, with coefficients of determination (R2) exceeding 0.80 for southern Germany. These results indicate that the response of the

  4. Solar cell with doped groove regions separated by ridges

    DOEpatents

    Molesa, Steven Edward; Pass, Thomas; Kraft, Steve

    2017-01-31

    Solar cells with doped groove regions separated by ridges and methods of fabricating solar cells are described. In an example, a solar cell includes a substrate having a surface with a plurality of grooves and ridges. A first doped region of a first conductivity type is disposed in a first of the grooves. A second doped region of a second conductivity type, opposite the first conductivity type, is disposed in a second of the grooves. The first and second grooves are separated by one of the ridges.

  5. Geologic and geochemical study of tin-bearing rhyolites in the Broken Ridge area, southern Wah Wah Mountains, Utah

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Duttweiler, K.A.; Griffitts, W.R.

    This study was undertaken to document the geologic, petrologic, and geochemical relationships of the tin-bearing rhyolitic lava flows and domes of the 12-m.y.-old Steamboat Mountain Formation of Thompson and Perry in the area of Broken Ridge. Early phases of volcanic activity produced a crystal-rich, topaz-bearing rhyolite flow followed by eruption of a crystal-poor rhyolite from many local centers. These geochemical characteristics are typical of other topaz-bearing rhyolites in the western United States and suggest that such rhyolites formed as highly differentiated magmas. The 23-m.y.-old Bible Spring fault zone was reactivated after emplacement of the rhyolite flows that resulted in amore » series of high-angle normal faults. Multiple hydrothermal events resulted in widespread alteration along the faults and concentration of Be, F, Sn, Nb, Mo, Cu, Zn, W, and Ba. Alteration types include silicification, argillization, and alunitization. Crystalline cassiterite and wood tin are widespread and locally abundant in heavy-mineral-concentrate samples from the Broken Ridge area. The only visible cassiterite in the rocks occurs with specular hematite in veins within the silicified topaz-bearing rhyolite, immediately adjacent to a vent breccia. Trace element anomalies of Sn, Mo, Nb, and Be in rock samples well-define the vein area. The combined geologic, geochemical, and structural data suggest that an intrusive may be at depth directly beneath Broken Ridge.« less

  6. Analysis of gravity and topography in the GLIMPSE study region: Isostatic compensation and uplift of the Sojourn and Hotu Matua Ridge systems

    USGS Publications Warehouse

    Harmon, N.; Forsyth, D.W.; Scheirer, D.S.

    2006-01-01

    The Gravity Lieations Intraplate Melting Petrologic and Seismic Expedition (GLIMPSE) Experiment investigated the formation of a series of non-hot spot, intraplate volcanic ridges in the South Pacific and their relationship to cross-grain gravity lineaments detected by satellite altimetry. Using shipboard gravity measurements and a simple model of surface loading of a thin elastic plate, we estimate effective elastic thicknesses ranging from ???2 km beneath the Sojourn Ridge to a maximum of 10 km beneath the Southern Cross Seamount. These elastic thicknesses are lower than predicted for the 3-9 Ma seafloor on which the volcanoes lie, perhaps due to reheating and thinning of the plate during emplacement. Anomalously low apparent densities estimated for the Matua and Southern Cross seamounts 2050 and 2250 kg m-3, respectively, probably are artifacts caused by the assumption of only surface loading, ignoring the presence of subsurface loading in the form of underplated crust and/or low-density mantle. Using satellite free-air gravity and shipboard bathymetry, we calculate the age-detrended, residual mantle Bouguer anomaly (rMBA). The rMBA corrects the free-air anomaly for the direct effects of topography, including the thickening of the crust beneath the seamounts and volcanic ridges due to surface loading of the volcanic edifices. There are broad, negative rMBA anomalies along the Sojourn and Brown ridges and the Hotu Matua seamount chain that extend nearly to the East Pacific Rise. These negative rMBA anomalies connect to negative free-air anomalies in the western part of the study area that have been recognized previously as the beginnings of the cross-grain gravity lineaments. Subtracting the topographic effects of surface loading by the ridges and seamounts from the observed topography reveals that the ridges are built on broad bands of anomalously elevated seafloor. This swell topography and the negative rMBA anomalies contradict the predictions of lithospheric

  7. Geochemistry and petrology of andesites from the north rift zone of Axial Seamount, Juan de Fuca Ridge

    NASA Astrophysics Data System (ADS)

    Smithka, I. N.; Perfit, M. R.; Clague, D. A.; Wanless, V. D.

    2014-12-01

    In 2013, the ROV Doc Ricketts onboard R/V Western Flyer explored ~4 km of an elongate pillow ridge up to ~300 m high along the eastern edge of the north rift zone of Axial Seamount. The steep-sided volcanic ridge is constructed of large pillow lavas up to 2-3 m in diameter and smaller elongated pillow tubes. Of the 27 samples collected during dive D526, all but one are andesites making it one of the largest confirmed high-silica exposures along a mid-ocean ridge (MOR). Based on radiocarbon ages of sediment on top of flows, the mounds are at least ~1390 years old. This minimum age is much younger than the 56 Ka age calculated based on distance from the rift axis, indicating eruption off-axis through older, colder crust and supporting the hypothesis and model calculations that extensive fractional crystallization (>85%) caused the high silica content. The andesitic lavas are primarily glassy, highly vesicular, crusty, and sparsely phyric with small (~1 mm) plagioclase crystals and olivine, clinopyroxene, and Fe-Ti oxide microphenocrysts. Microprobe analyses of glasses are similar to wax-core samples previously collected from this area but are more compositionally variable. Excluding one basalt (7.7 wt% MgO) sampled between mounds, the lavas are basaltic andesites and andesites (53-59 wt% SiO2) with <3 wt% MgO and 12.8-15.7 wt% FeO concentrations. Incompatible trace element abundances are ~4-6 times more enriched than in Axial Seamount T-MORB. Primitive mantle-normalized patterns are similar to those of high-silica lavas from other MORs (southern Juan de Fuca Ridge, 9N East Pacific Rise) with significant positive U anomalies, large negative Sr anomalies, small negative Eu anomalies, and slight positive Zr-Hf anomalies. The andesites are more enriched in light rare earth elements than basalts from Axial Seamount ((La/Yb)N 1.35-1.4 vs. 0.7-1.27) and N-MORB from the southern Juan de Fuca Ridge. The andesites also have high Cl (~0.3-0.6 wt%) and H2O (~1.60-1.71 wt

  8. Magma Supply at the Arctic Gakkel Ridge: Constraints from Peridotites and Basalts

    NASA Astrophysics Data System (ADS)

    Sun, C.; Dick, H. J.; Hellebrand, E.; Snow, J. E.

    2015-12-01

    Crustal thickness in global ridge systems is widely believed to be nearly uniform (~7 km) at slow- and fast-spreading mid-ocean ridges, but appears significantly thinner (< ~4 km) at ultraslow-spreading ridges. At the slowest-spreading Arctic Gakkel Ridge, the crust becomes extremely thin (1.4 - 2.9 km; [1]). The thin crust at the Gakkel and other ultraslow-spreading ridges, has been attributed to lithosphere thickening, ancient mantle depletion, lower mantle temperature, ridge obliquity, and melt retention/focusing. To better understand the magma supply at ultraslow-spreading ridges, we examined melting dynamics by linking peridotites and basalts dredged along the Gakkel Ridge. We analyzed rare earth elements in clinopyroxene from 84 residual peridotites, and estimated melting parameters for individual samples through nonlinear least squares analyses. The degrees of melting show a large variation but mainly center at around 7% assuming a somewhat arbitrary but widely used depleted MORB mantle starting composition. Thermobarometry on published primitive basaltic glasses from [2] indicates that the mantle potential temperature at the Gakkel Ridge is ~50°C cooler than that at the East Pacific Rise. The ridge-scale low-degree melting and lower mantle potential temperature place the final depth of melting at ~30 km and a melt thickness of 1.0 or 2.9 km for a triangular or trapezoidal melting regime, respectively. The final melting depth is consistent with excess conductive cooling and lithosphere thickening suggested by geodynamic models, while the estimated melt thickness is comparable to the seismic crust (1.4 - 2.9 km; [1]). The general agreement among geochemical analyses, seismic measurements, and geodynamic models supports that lower mantle potential temperature and thick lithosphere determine the ridge-scale low-degree melting and thin crust at the Gakkel Ridge, while melt retention/focusing and excess ancient mantle depletion are perhaps locally important at

  9. Beach ridge sedimentology: field observation and palaeoenvironmental interpretation for Anegada Island, British Virgin Islands.

    NASA Astrophysics Data System (ADS)

    Cescon, Anna Lisa; Cooper, J. Andrew G.; Jackson, Derek W. T.

    2014-05-01

    Beach ridge landforms have been observed in different environments and in settings that range from polar to tropical. Their stratigraphy and sedimentology has received a limited amount of discussion in the literature (Tamura, 2012). In coastal geomorphology a beach ridge can be seen as a transitional deposit between onshore and offshore environments. They are regarded as representing high level wave action along a coastline. In the Caribbean the origin of beach ridges has been variously attributed to one of three extreme wave events: extreme swell, extreme storm or tsunami waves. Beach ridges are arranged in beach ridge plains where there is succession of the landforms and can be several kilometres long. Beach ridge accumulation is not continuous and the coast shows alternating accretion and erosion periods. The use of beach ridges as palaeostorm archives is therefore not straightforward. The temporal continuity of beach ridge formation is being assessed on the beach ridge plains of Anegada, British Virgin Islands (Lesser Antilles). This carbonate platform surrounded by a fringing reef contains two beach ridge plains. There are more than 30 ridges in the Atlantic facing- coast and around 10 in the south, Caribbean- facing coast. The sediments of the modern beaches are dominated by the sand fraction and are 100% biogenic origin due to the isolation of Anegada from terrestrial sediment sources. The beach ridge sections have been studied in different area of Anegada beach ridge plains and present low angle seaward-dipping bedding. The sand fraction is dominant in the stratigraphy with a few intact shells. At only one site were coral pebbles deposited in association with the sand fraction. Aeolian deposits represent the upper part of the beach ridges and reflect the stabilization of the beach ridges with ongoing accretion. The sedimentology of the contemporary beach and dunes will be discussed in terms of their implications for understanding beach ridge genesis and its

  10. Oak Ridge TNS Program: system description manual

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Reid, R.L.; Becraft, W.R.; Brown, T.G.

    1979-05-01

    This document provides a systems description of the Reference Design for The Next Step (TNS) evolved at Oak Ridge National Laboratory (ORNL) during FY 1978. The description is presented on the basis of 24 individual device and facility systems. Additional information on these systems, the Reference Design, and the FY 1978 Oak Ridge TNS activities can be found in the associated technical memoranda, ORNL/TM-6720 and ORNL/TM-6722--ORNL/TM-6733.

  11. Ridge-trench collision in Archean and Post-Archean crustal growth: Evidence from southern Chile

    NASA Technical Reports Server (NTRS)

    Nelson, E. P.; Forsythe, R. D.

    1988-01-01

    The growth of continental crust at convergent plate margins involves both continuous and episodic processes. Ridge-trench collision is one episodic process that can cause significant magmatic and tectonic effects on convergent plate margins. Because the sites of ridge collision (ridge-trench triple junctions) generally migrate along convergent plate boundaries, the effects of ridge collision will be highly diachronous in Andean-type orogenic belts and may not be adequately recognized in the geologic record. The Chile margin triple junction (CMTJ, 46 deg S), where the actively spreading Chile rise is colliding with the sediment-filled Peru-Chile trench, is geometrically and kinematically the simplest modern example of ridge collision. The south Chile margin illustrates the importance of the ridge-collision tectonic setting in crustal evolution at convergent margins. Similarities between ridge-collision features in southern Chile and features of Archean greenstone belts raise the question of the importance of ridge collision in Archean crustal growth. Archean plate tectonic processes were probably different than today; these differences may have affected the nature and importance of ridge collision during Archean crustal growth. In conclusion, it is suggested that smaller plates, greater ridge length, and/or faster spreading all point to the likelihood that ridge collision played a greater role in crustal growth and development of the greenstone-granite terranes during the Archean. However, the effects of modern ridge collision, and the processes involved, are not well enough known to develop specific models for the Archean ridge collison.

  12. Ridge-branch-based blood vessel detection algorithm for multimodal retinal images

    NASA Astrophysics Data System (ADS)

    Li, Y.; Hutchings, N.; Knighton, R. W.; Gregori, G.; Lujan, B. J.; Flanagan, J. G.

    2009-02-01

    Automatic detection of retinal blood vessels is important to medical diagnoses and imaging. With the development of imaging technologies, various modals of retinal images are available. Few of currently published algorithms are applied to multimodal retinal images. Besides, the performance of algorithms with pathologies is expected to be improved. The purpose of this paper is to propose an automatic Ridge-Branch-Based (RBB) detection algorithm of blood vessel centerlines and blood vessels for multimodal retinal images (color fundus photographs, fluorescein angiograms, fundus autofluorescence images, SLO fundus images and OCT fundus images, for example). Ridges, which can be considered as centerlines of vessel-like patterns, are first extracted. The method uses the connective branching information of image ridges: if ridge pixels are connected, they are more likely to be in the same class, vessel ridge pixels or non-vessel ridge pixels. Thanks to the good distinguishing ability of the designed "Segment-Based Ridge Features", the classifier and its parameters can be easily adapted to multimodal retinal images without ground truth training. We present thorough experimental results on SLO images, color fundus photograph database and other multimodal retinal images, as well as comparison between other published algorithms. Results showed that the RBB algorithm achieved a good performance.

  13. Ultra-fast pulse propagation in nonlinear graphene/silicon ridge waveguide

    NASA Astrophysics Data System (ADS)

    Liu, Ken; Zhang, Jian Fa; Xu, Wei; Zhu, Zhi Hong; Guo, Chu Cai; Li, Xiu Jian; Qin, Shi Qiao

    2015-11-01

    We report the femtosecond laser propagation in a hybrid graphene/silicon ridge waveguide with demonstration of the ultra-large Kerr coefficient of graphene. We also fabricated a slot-like graphene/silicon ridge waveguide which can enhance its effective Kerr coefficient 1.5 times compared with the graphene/silicon ridge waveguide. Both transverse-electric-like (TE-like) mode and transverse-magnetic-like (TM-like) mode are experimentally measured and numerically analyzed. The results show nonlinearity dependence on mode polarization not in graphene/silicon ridge waveguide but in slot-like graphene/silicon ridge waveguide. Great spectral broadening was observed due to self-phase modulation (SPM) after propagation in the hybrid waveguide with length of 2 mm. Power dependence property of the slot-like hybrid waveguide is also measured and numerically analyzed. The results also confirm the effective Kerr coefficient estimation of the hybrid structures. Spectral blue shift of the output pulse was observed in the slot-like graphene/silicon ridge waveguide. One possible explanation is that the blue shift was caused by the ultra-fast free carrier effect with the optical absorption of the doped graphene. This interesting effect can be used for soliton compression in femtosecond region. We also discussed the broadband anomalous dispersion of the Kerr coefficient of graphene.

  14. Mechanics of gravitational spreading of steep-sided ridges («sackung»)

    USGS Publications Warehouse

    Savage, W.Z.; Varnes, D.J.

    1987-01-01

    Large-scale gravitational spreading of steep-sided ridges characterized by linear fissures, trenches, and uphill-facing scarps high on the sides and tops of ridges are known worldwide. Such spreading, termed sackung, is commonly attributed to pervasive plastic deformation of a rock mass, and is here analyzed as such. Beginning with a previously developed exact elastic solution for gravity-induced stresses in a symmetric ridge, stresses calculated from the exact solution are used in the Coulomb failure criterion to determine the extent of ridge failure under self-weight. Finally, when the regions of failure are established, a plastic flow solution is applied to predict the location of and sense of movement on upward-facing scarps near ridge crests and other features common in sackung. ?? 1987 International Assocaition of Engineering Geology.

  15. Melton Valley Storage Tanks Capacity Increase Project, Oak Ridge National Laboratory, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-04-01

    The US Department of Energy (DOE) proposes to construct and maintain additional storage capacity at Oak Ridge National Laboratory (ORNL), Oak Ridge, Tennessee, for liquid low-level radioactive waste (LLLW). New capacity would be provided by a facility partitioned into six individual tank vaults containing one 100,000 gallon LLLW storage tank each. The storage tanks would be located within the existing Melton Valley Storage Tank (MVST) facility. This action would require the extension of a potable water line approximately one mile from the High Flux Isotope Reactor (HFIR) area to the proposed site to provide the necessary potable water for themore » facility including fire protection. Alternatives considered include no-action, cease generation, storage at other ORR storage facilities, source treatment, pretreatment, and storage at other DOE facilities.« less

  16. The Effects of Ridge Axis Width on Mantle Melting at Mid-Ocean Ridges

    NASA Astrophysics Data System (ADS)

    Montesi, L.; Magni, V.; Gaina, C.

    2017-12-01

    Mantle upwelling in response to plate divergence produces melt at mid-ocean ridges. Melt starts when the solidus is crossed and stops when conductive cooling overcomes heat advection associated with the upwelling. Most mid-ocean ridge models assume that divergence takes place only in a narrow zone that defines the ridge axis, resulting in a single upwelling. However, more complex patterns of divergence are occasionally observed. The rift axis can be 20 km wide at ultraslow spreading center. Overlapping spreading center contain two parallel axes. Rifting in backarc basins is sometimes organized as a series of parallel spreading centers. Distributing plate divergence over several rifts reduces the intensity of upwelling and limits melting. Can this have a significant effect on the expected crustal thickness and on the mode of melt delivery at the seafloor? We address this question by modeling mantle flow and melting underneath two spreading centers separated by a rigid block. We adopt a non-linear rheology that includes dislocation creep, diffusion creep and yielding and include hydrothermal cooling by enhancing thermal conductivity where yielding takes place. The crustal thickness decreases if the rifts are separated by 30 km or more but only if the half spreading rate is between 1 and 2 cm/yr. At melting depth, a single upwelling remains the norm until the separation of the rifts exceeds a critical value ranging from 15 km in the fastest ridges to more than 50 km at ultraslow spreading centers. The stability of the central upwelling is due to hydrothermal cooling, which prevents hot mantle from reaching the surface at each spreading center. When hydrothermal cooling is suppressed, or the spreading centers are sufficiently separated, the rigid block becomes extremely cold and separates two distinct, highly asymmetric upwellings that may focus melt beyond the spreading center. In that case, melt delivery might drive further and further the divergence centers, whereas

  17. Noachian Impact Ejecta on Murray Ridge and Pre-impact Rocks on Wdowiak Ridge, Endeavour Crater, Mars: Opportunity Observations

    NASA Technical Reports Server (NTRS)

    Mittlefehldt, D. W.; Gellert, R.; Ming, D. W.; Morris, R. V.; Schroeder, C.; Yen, A. S.; Farrand, W. H.; Arvidson, R. E.; Franklin, B. J.; Grant, J. A.; hide

    2015-01-01

    Mars Exploration Rover Opportunity has been exploring Meridiani Planum since January 2004, and has completed 4227% of its primary mission. Opportunity has been investigating the geology of the rim of 22 km diameter Endeavour crater, first on the Cape York segment and now on Cape Tribulation. The outcrops are divided York; (ii) the Shoemaker fm, impact breccias representing ejecta from the crater; into three formations: (i) the lower Matijevic fm, a pre-impact lithology on Cape and (iii) the upper Grasberg fm, a post-impact deposit that drapes the lower portions of the eroded rim segments. On the Cape Tribulation segment Opportunity has been studying the rocks on Murray Ridge, with a brief sojourn to Wdowiak Ridge west of the rim segment. team member Thomas Wdowiak, who died in 2013.) One region of Murray Ridge has distinctive CRISM spectral characteristics indicating the presence of a small concentration of aluminous smectite based on a 2.2 micron Al-OH combination band (hereafter, the Al-OH region).

  18. Pelagic erosion and sedimentation north of Carnegie Ridge, eastern equatorial Pacific

    NASA Astrophysics Data System (ADS)

    Brooks, C. K.; Lyle, M. W.; Marcantonio, F.; Lewis, D. M.; Paul, C.

    2011-12-01

    The Carnegie Ridge is one of three bathymetric highs bounding the Panama Basin and is known to exhibit erosion and redeposition of pelagic sediments. The extent of erosion and redeposition was studied during the R/V Melville cruise MV1014 in November 2010 to compare with geochemical estimates of sediment focusing. The MV1014 cruise acquired geochemical, geological and geophysical data using multichannel 2-D seismic and 3.5 kHz sub-bottom profiler, swathmap bathymetry, coring, and water casts. The seismic reflection, digital sub-bottom profiler and swathmap bathymetry data were used to investigate biogenic sedimentary deposition in the Panama Basin and erosion from Carnegie Ridge. We compare the new geophysical results with drilling on ODP Leg 202, the NEMO-03 site survey cruise for Leg 202, an early survey from 1969 and other data compiled by Ecuadorian surveys. Areas of non-deposition and/or erosion include the bathymetric highs along the ridge, seamounts, and an area of interest, a valley located on the northwestern flank of the ridge. The valley encompasses 183 km2 and exhibits large scale erosion, cutting down through sediments deposited over the 10-million year life of this segment of the Carnegie Ridge. All other valleys located within the Carnegie Ridge study area demonstrate ample deposition with sedimentary packages ranging from 200-800m with an average value trending around 400m. Higher sediment deposition is found in basins to the north of the erosional valley but similar sedimentation is also found even further north, beyond intervening high topography. The thickest sediment deposit near the Carnegie Ridge is actually found on the southern flank of the ridge, more than 100 km to the south of the survey area. Digital chirp sub-bottom profiler data combined with high-resolution seismic illustrate changes in sedimentation and erosion on the Carnegie Ridge, highlighting the dynamic sedimentary environment.

  19. Strike-slip faulting of ridged plains near Valles Marineris, Mars

    NASA Astrophysics Data System (ADS)

    Schultz, R. A.

    1989-10-01

    This paper identifies and documents several well-preserved examples of Martian strike-slip faults and examines their relationships to wrinkle-ridges. The strike-slip faulting predates or overlaps periods of wrinkle-ridge growth southeast of Valles Marineris, and some wrinkle ridges may have nucleated and grown as a result of strike-slip displacements along the echelon fault arrays. Lateral displacements of several km inferred along these arrays may be related to tectonism in Tharsis.

  20. Evidence for chemically heterogeneous Arctic mantle beneath the Gakkel Ridge

    NASA Astrophysics Data System (ADS)

    D'Errico, Megan E.; Warren, Jessica M.; Godard, Marguerite

    2016-02-01

    Ultraslow spreading at mid-ocean ridges limits melting due to on-axis conductive cooling, leading to the prediction that peridotites from these ridges are relatively fertile. To test this, we examined abyssal peridotites from the Gakkel Ridge, the slowest spreading ridge in the global ocean ridge system. Major and trace element concentrations in pyroxene and olivine minerals are reported for 14 dredged abyssal peridotite samples from the Sparsely Magmatic (SMZ) and Eastern Volcanic (EVZ) Zones. We observe large compositional variations among peridotites from the same dredge and among dredges in close proximity to each other. Modeling of lherzolite trace element compositions indicates varying degrees of non-modal fractional mantle melting, whereas most harzburgite samples require open-system melting involving interaction with a percolating melt. All peridotite chemistry suggests significant melting that would generate a thick crust, which is inconsistent with geophysical observations at Gakkel Ridge. The refractory harzburgites and thin overlying oceanic crust are best explained by low present-day melting of a previously melted heterogeneous mantle. Observed peridotite compositional variations and evidence for melt infiltration demonstrates that fertile mantle components are present and co-existing with infertile mantle components. Melt generated in the Gakkel mantle becomes trapped on short length-scales, which produces selective enrichments in very incompatible rare earth elements. Melt migration and extraction may be significantly controlled by the thick lithosphere induced by cooling at such slow spreading rates. We propose the heterogeneous mantle that exists beneath Gakkel Ridge is the consequence of ancient melting, combined with subsequent melt percolation and entrapment.

  1. Buldir Depression - A Late Tertiary graben on the Aleutian Ridge, Alaska

    USGS Publications Warehouse

    Marlow, M. S.; Scholl, D. W.; Buffington, E.C.; Boyce, R.E.; Alpha, T.R.; Smith, P.J.; Shipek, C.J.

    1970-01-01

    Buldir Depression is a large, rectilinear basin that lies on the northern edge of the Aleutian Ridge and is aligned with the arcuate chain of active volcanoes on the ridge crest. The depression appears to be a volcanic-tectonic feature, which began to form in Late Tertiary time and which is still forming. It is a graben formed by extensional rifting and accompanied by contemporaneous volcanism on the Aleutian Ridge. Subsidence rates for the depression are estimated at 20-70 cm/1,000 years. Sediments in the depression are 300 m thick and are probably pelagic and turbidite deposits of Pleistocene age. The turbidites were apparently derived from the plateau area of the Aleutian Ridge surrounding the depression. Older sediments on the northern slope of the Aleutian Ridge have a maximum thickness of 550 m and are deformed and slumped toward the Bering Sea. These sediments are postulated to overlie a mid-flank terrace on the northern Aleutian Ridge that titled to the north during the formation of Buldir Depression. ?? 1970.

  2. Intraplate compressional deformation in West-Congo and the Congo basin: related to ridge-puch from the South Atlantic spreading ridge?

    NASA Astrophysics Data System (ADS)

    Delvaux, Damien; Everaerts, Michel; Kongota Isasi, Elvis; Ganza Bamulezi, Gloire

    2016-04-01

    After the break-up and separation of South America from Africa and the initiation of the South-Atlantic mid-oceanic ridge in the Albian, at about 120 Ma, ridge-push forces started to build-up in the oceanic lithosphere and were transmitted to the adjacent continental plates. This is particularly well expressed in the passive margin and continental interior of Central Africa. According to the relations of Wiens and Stein (1985) between ridge-push forces and basal drag in function of the lithospheric age of oceanic plates, the deviatoric stress reaches a compressional maximum between 50 and 100, Ma after the initiation of the spreading ridge, so broadly corresponding to the Paleocene in this case (~70-20 Ma). Earthquake focal mechanism data show that the West-Congo margin and a large part of the Congo basin are still currently under compressional stresses with an horizontal compression parallel to the direction of the active transform fracture zones. We studied the fracture network along the Congo River in Kinshasa and Brazzaville which affect Cambrian sandstones and probably also the late Cretaceous-Paleocene sediments. Their brittle tectonic evolution is compatible with the buildup of ridge-push forces related to the South-Atlantic opening. Further inland, low-angle reverse faults are found affecting Jurassic to Middle Cretaceous cores from the Samba borehole in the Congo basin and strike-slip movements are recorded as a second brittle phase in the Permian cores of the Dekese well, at the southern margin of the Congo basin. An analysis of the topography and river network of the Congo basin show the development of low-amplitude (50-100 m) long wavelengths (100-300 km) undulations that can be interpreted as lithospheric buckling in response to the compressional intraplate stress field generated by the Mid-Atlantic ridge-push. Wiens, D.A., Stein, S., 1985. Implications of oceanic intraplate seismicity for plate stresses, driving forces and theology. Tectonophysics

  3. Global Models of Ridge-Push Force, Geoid, and Lithospheric Strength of Oceanic plates

    NASA Astrophysics Data System (ADS)

    Mahatsente, Rezene

    2017-12-01

    An understanding of the transmission of ridge-push related stresses in the interior of oceanic plates is important because ridge-push force is one of the principal forces driving plate motion. Here, I assess the transmission of ridge-push related stresses in oceanic plates by comparing the magnitude of the ridge-push force to the integrated strength of oceanic plates. The strength is determined based on plate cooling and rheological models. The strength analysis includes low-temperature plasticity (LTP) in the upper mantle and assumes a range of possible tectonic conditions and rheology in the plates. The ridge-push force has been derived from the thermal state of oceanic lithosphere, seafloor depth and crustal age data. The results of modeling show that the transmission of ridge-push related stresses in oceanic plates mainly depends on rheology and predominant tectonic conditions. If a lithosphere has dry rheology, the estimated strength is higher than the ridge-push force at all ages for compressional tectonics and at old ages (>75 Ma) for extension. Therefore, under such conditions, oceanic plates may not respond to ridge-push force by intraplate deformation. Instead, the plates may transmit the ridge-push related stress in their interior. For a wet rheology, however, the strength of young lithosphere (<75 Ma) is much less than the ridge-push force for both compressional and extensional tectonics. In this case, the ridge-push related stress may dissipate in the interior of oceanic plates and diffuses by intraplate deformation. The state of stress within a plate depends on the balance of far-field and intraplate forces.

  4. Volcanism, jump and propagation on the Sheba ridge, eastern Gulf of Aden: segmentation evolution and implications for oceanic accretion processes

    NASA Astrophysics Data System (ADS)

    d'Acremont, Elia; Leroy, Sylvie; Maia, Marcia; Gente, Pascal; Autin, Julia

    2010-02-01

    The rifting between Arabia and Somalia, which started around 35 Ma, was followed by oceanic accretion from at least 17.6 Ma leading to the formation of the present-day Gulf of Aden. Bathymetric, gravity and magnetic data from the Encens-Sheba cruise are used to constrain the structure and segmentation of the oceanic basin separating the conjugate continental margins in the eastern part of the Gulf of Aden between 51°E and 55.5°E. Data analysis reveals that the oceanic domain along this ridge section is divided into two distinct areas. The Eastern area is characterized by a shorter wavelength variation of the axial segmentation and an extremely thin oceanic crust. In the western segment, a thicker oceanic crust suggests a high melt supply. This supply is probably due to an off-axis melting anomaly located below the southern flank of the Sheba ridge, 75 km east of the major Alula-Fartak transform fault. This suggests that the axial morphology is produced by a combination of factors, including spreading rate, melt supply and the edge effect of the Alula-Fartak transform fault, as well as the proximity of the continental margin. The oceanic domains have undergone two distinct phases of accretion since the onset of seafloor spreading, with a shift around 11 Ma. At that time, the ridge jumped southwards, in response to the melting anomaly. Propagating ridges were triggered by the melting activity, and propagated both eastward and westward. The influence of the melting anomaly on the ridges decreased, stopping their propagation since less than 9 Ma. From that time up to the present, the N025°E-trending Socotra transform fault developed in association with the formation of the N115°E-trending segment #2. In recent times, a counter-clockwise rotation of the stress field associated with kinematic changes could explain the structural morphology of the Alula-Fartak and Socotra-Hadbeen fracture zones.

  5. Progressive serpentinization of the oceanic lithosphere from ridge to ridge flank: Consequences for biogeochemical cycles

    NASA Astrophysics Data System (ADS)

    Frueh-Green, G. L.; Boschi, C.

    2011-12-01

    Exposure of mantle rocks is an integral process of slow- and ultra-slow spreading ridges and ridge-flanks. Mantle-dominated lithosphere is a highly reactive chemical and thermal system, in which progressive interaction with seawater during serpentinization has significant geophysical, geochemical and biological consequences for the global marine system. This presentation is intended to provide an overview of serpentinization processes as fundamental to understanding the evolution of oceanic lithosphere formed at slow spreading ridges, fluid flow and the consequences of serpentinization for biogeochemical cycles. Seawater progressively reacts with peridotite, commonly as detachment faults unroof mantle material to the seafloor and serpentinites become dominant components of the ridge flanks. The mineral assemblages and textures of abyssal serpentinites typically record progressive, static hydration reactions that take place under a wide range of temperatures, lithospheric depths, fluid compositions and redox conditions. The products and sequence of serpentinization reactions are influenced by the time-integrated flux of seawater, bulk protolith compositions, the presence or absence of magmatic intrusions and/or trapped gabbroic melts, and structure (e.g., detachment faults, cataclastic fault zones). In turn, these factors influence mineral assemblages, fluid chemistry, and volatile contents. Serpentinization processes have major consequences for long-term, global geochemical fluxes by acting as a sink for H2O, Cl, B, U, S, and C from seawater and a source of Ca, Ni and possibly Cr to hydrothermal fluids, and by producing hydrogen-rich reduced fluids that are critical to sustain microbial communities. Seafloor weathering of serpentinized abyssal peridotites may also result in Mg loss and enhanced B uptake during clay mineral formation. The production of hydrogen during serpentinization is generally attributed to the formation of magnetite during olivine hydration and

  6. 60 Years of Great Science (Oak Ridge National Laboratory)

    DOE R&D Accomplishments Database

    2003-01-01

    This issue of Oak Ridge National Laboratory Review (vol. 36, issue 1) highlights Oak Ridge National Laboratory's contributions in more than 30 areas of research and related activities during the past 60 years and provides glimpses of current activities that are carrying on this heritage.

  7. Community-Wide Education Outreach for the Ridge2000 Research Program

    NASA Astrophysics Data System (ADS)

    Goehring, E.

    2004-12-01

    Ridge2000 is a multidisciplinary NSF sponsored research initiative to explore Earth's spreading ridge system as an integrated whole. The Ridge2000 community is comprised of scientists from universities and research institutions across the country. Building on existing exemplary outreach efforts (e.g., REVEL, Dive&Discover, Volcanoes of the Deep Sea IMAX), Ridge2000 education outreach has begun to develop community-wide education offerings - programs to which Ridge2000 scientists and others may contribute. Community-wide efforts offer the advantages of serving larger audiences of scientists as well as educators and students and providing avenues for scientists interested in education outreach but with limited time or experience. Coordination of researchers' educational efforts also better leverages the resources of the funding agency - NSF. Here we discuss an exciting Ridge2000 pilot program called SEAS - Student Experiments At Sea. SEAS is a web-based program for middle and high school students to learn science by doing science. SEAS students study the exciting, relatively unexplored world of hydrothermal vents and learn to ask questions about this environment just as researchers do. SEAS goes beyond "follow-along" outreach by inviting students to participate in research through formal proposal and report competitions. The program was concept-tested during the 2003-2004 academic year, with 14 pilot teachers and approximately 800 students. Five student experiments were conducted at sea, with data posted to the website during the cruise. Student reports as well as scientist comments are posted there as well (http://www.ridge2000.org/SEAS/). It was an exciting year! Over 20 Ridge2000 scientists contributed their time and expertise to the SEAS program in its first year. Scientists are invited to contribute in a variety of ways, all of which help satisfy the requirement's of NSF's Broader Impacts Criterion. They may help develop curriculum topics, consult on

  8. Formation and Elimination of Transform Faults on the Reykjanes Ridge

    NASA Astrophysics Data System (ADS)

    Martinez, Fernando; Hey, Richard

    2017-04-01

    The Reykjanes Ridge is a type-setting for examining processes that form and eliminate transform faults because it has undergone these events systematically within the Iceland gradient in hot-spot influence. A Paleogene change in plate motion led to the abrupt segmentation of the originally linear axis into a stair-step ridge-transform configuration. Its subsequent evolution diachronously and systematically eliminated the just-formed offsets re-establishing the original linear geometry of the ridge over the mantle, although now spreading obliquely. During segmented stages accreted crust was thinner and during unsegmented stages southward pointing V-shaped crustal ridges formed. Although mantle plume effects have been invoked to explain the changes in segmentation and crustal features, we propose that plate boundary processes can account for these changes [Martinez & Hey, EPSL, 2017]. Fragmentation of the axis was a mechanical effect of an abrupt change in plate opening direction, as observed in other areas, and did not require mantle plume temperature changes. Reassembly of the fragmented axis to its original linear configuration was controlled by a deep damp melting regime that persisted in a linear configuration following the abrupt change in opening direction. Whereas the shallow and stronger mantle of the dry melting regime broke up into a segmented plate boundary, the persistent deep linear damp melting regime guided reassembly of the ridge axis back to its original configuration by inducing asymmetric spreading of individual ridge segments. Effects of segmentation on mantle upwelling explain crustal thickness changes between segmented and unsegmented phases of spreading without mantle temperature changes. Buoyant upwelling instabilities propagate along the long linear deep melting regime driven by regional gradients in mantle properties away from Iceland. Once segmentation is eliminated, these propagating upwelling instabilities lead to crustal thickness

  9. Sedimentary and structural patterns on the northern Santa Rosa-Cortes Ridge, southern California

    USGS Publications Warehouse

    Field, M.E.; Richmond, W.C.

    1980-01-01

    The Santa Rosa-Cortes Ridge is an 1800 m high, 180 km long feature lying approximately 90 km off the coast of southern California and directly south of the northern group of Channel Islands. Geophysical profiling and sampling cruises to the northern part of the ridge, an area of recent and future lease sales for petroleum development, provide a strong data base for interpretation of structural and sedimentary patterns and their relation to potential geologic hazards. The northern part of the ridge is a complexly folded and faulted northwest-trending anticlinorium composed mostly of lower and middle Miocene shale and mudstone. Erosional remnants of upper Miocene and Pliocene rocks unconformably overlie highly folded pre-upper Miocene strata. The major structure of the ridge developed almost continuously from Oligocene or early Miocene time to the end of the Tertiary; many small folds formed between post-late Miocene and pre-late Pleistocene time. Numerous small faults cut the rocks on the ridge top. Faults cut basement rocks on the west side of the ridge along the Ferrelo fault zone. Published data on historical epicenters and evidence of offsets on the seafloor from seismic reflection and side-scan profiles, including limited evidence of possible strike-slip movement along fault traces, indicate that the northern Santa Rosa-Cortes Ridge is tectonically active. The crest of the ridge was truncated as the result of repeated sea-level fluctuations in the Quaternary. A thin veneer of unconsolidated medium to fine sand, less than 3 m thick, mantles most of the ridge; locally in topographically low areas and on the upper flanks of the ridge, thickness exceeds 20 m. The meager sediment cover, coupled with available evidence of relatively strong currents flowing across the ridge top, indicate that the ridge is an area of nondeposition or winnowing of fine sediments. Modern sediments become thicker and finer-grained from the ridge top to the ridge flanks, suggesting active

  10. Magnetic Anomalies over the Mid-Atlantic Ridge near 27{degrees}N.

    PubMed

    Phillips, J D

    1967-08-25

    Ten magnetic profiles across the mid-Atlantic ridge near 27 degrees N show trends that are parallel to the ridge axis and symmetrical about the ridge axis. The configuration of magnetic bodies that could account for the pattern supports the Vine and Matthews hypothesis for the origin of magnetic anomalies over oceanic ridges. A polarity-reversal time scale inferred from models for sea-floor spreading in the Pacific-Antarctic ridge and radiometrically dated reversals of the geomagnetic field indicates a spreading rate of 1.25 centimeters per year during the last 6 million years and a rate of 1.65 centimeters per year between 6 and 10 million years ago. A similar analysis of more limited data over the mid-Atlantic ridge near 22 degrees N also indicates a change in the spreading rate. Here a rate of 1.4 centimeters per year appears to have been in effect during the last 5 million years; between 5 and 9 million years ago, an increased rate of 1.7 centimeters per year is indicated. The time of occurrence and relative magnitude of these changes in the spreading rate, about 5 to 6 million years ago and 18 to 27 percent, respectively, accords with the spreading rate change implied for the Juan de Fuca ridge in the northeast Pacific.

  11. The Sagatu Ridge dike swarm, Ethiopian rift margin. [tectonic evolution

    NASA Technical Reports Server (NTRS)

    Mohr, P. A.; Potter, E. C.

    1976-01-01

    A swarm of dikes forms the core of the Sagatu Ridge, a 70-km-long topographic feature elevated to more than 4000 m above sea level and 1500 m above the level of the Eastern (Somalian) plateau. The ridge trends NNE and lies about 50 km east of the northeasterly trending rift-valley margin. Intrusion of the dikes and buildup of the flood-lava pile, largely hawaiitic but with trachyte preponderant in the final stages, occurred during the late Pliocene-early Pleistocene and may have been contemporaneous with downwarping of the protorift trough to the west. The ensuing faulting that formed the present rift margin, however, bypassed the ridge. The peculiar situation and orientation of the Sagatu Ridge, and its temporary existence as a line of crustal extension and voluminous magmatism, are considered related to a powerful structural control by a major line of Precambrian crustal weakness, well exposed further south. Transverse rift structures of unknown type appear to have limited the development of the ridge to the north and south.

  12. Extraction of lead and ridge characteristics from SAR images of sea ice

    NASA Technical Reports Server (NTRS)

    Vesecky, John F.; Smith, Martha P.; Samadani, Ramin

    1990-01-01

    Image-processing techniques for extracting the characteristics of lead and pressure ridge features in SAR images of sea ice are reported. The methods are applied to a SAR image of the Beaufort Sea collected from the Seasat satellite on October 3, 1978. Estimates of lead and ridge statistics are made, e.g., lead and ridge density (number of lead or ridge pixels per unit area of image) and the distribution of lead area and orientation as well as ridge length and orientation. The information derived is useful in both ice science and polar operations for such applications as albedo and heat and momentum transfer estimates, as well as ship routing and offshore engineering.

  13. Mid-ocean-ridge seismicity reveals extreme types of ocean lithosphere.

    PubMed

    Schlindwein, Vera; Schmid, Florian

    2016-07-14

    Along ultraslow-spreading ridges, where oceanic tectonic plates drift very slowly apart, conductive cooling is thought to limit mantle melting and melt production has been inferred to be highly discontinuous. Along such spreading centres, long ridge sections without any igneous crust alternate with magmatic sections that host massive volcanoes capable of strong earthquakes. Hence melt supply, lithospheric composition and tectonic structure seem to vary considerably along the axis of the slowest-spreading ridges. However, owing to the lack of seismic data, the lithospheric structure of ultraslow ridges is poorly constrained. Here we describe the structure and accretion modes of two end-member types of oceanic lithosphere using a detailed seismicity survey along 390 kilometres of ultraslow-spreading ridge axis. We observe that amagmatic sections lack shallow seismicity in the upper 15 kilometres of the lithosphere, but unusually contain earthquakes down to depths of 35 kilometres. This observation implies a cold, thick lithosphere, with an upper aseismic zone that probably reflects substantial serpentinization. We find that regions of magmatic lithosphere thin dramatically under volcanic centres, and infer that the resulting topography of the lithosphere-asthenosphere boundary could allow along-axis melt flow, explaining the uneven crustal production at ultraslow-spreading ridges. The seismicity data indicate that alteration in ocean lithosphere may reach far deeper than previously thought, with important implications towards seafloor deformation and fluid circulation.

  14. A seismically active section of the Southwest Indian Ridge

    NASA Astrophysics Data System (ADS)

    Wald, David J.; Wallace, Terry C.

    1986-10-01

    The section of the Southwest Indian Ocean Ridge west of the Prince Edward Fracture zone has a large ridge axis offset and a complicated ridge-transform morphology. We have determined the source mechanisms of transform earthquakes along this portion of the ridge from an inversion of long-period P and SH waveforms. The seismicity is characterized by anomalous faulting mechanisms, source complexity and an unexpectedly large seismic moment release. Several earthquakes with dip-slip components of faulting have been recognized on the central section of the Andrew Bain and 32° E transforms suggesting geometrical complexity along the transform. This region has experienced a Mw = 8.0 transform earthquake in 1942, yet we observe a seismic slip rate during the last 20 years that is still comparable to the predicted spreading rate (1.6 cm/yr). The calculated slip rate over a period of 60 years is three times greater than the expected rate of spreading.

  15. Stability of highwalls in surface coal mines, western Powder Ridge Basin, Wyoming and Montana

    USGS Publications Warehouse

    Lee, Fitzhugh T.; Smith, William K.; Savage, William Z.

    1976-01-01

    Preliminary results from the first part of a two-part investigation of the stability of highwalls in open-pit coal mines in the Fort Union Formation of the western Powder River Basin of Wyoming and Montana indicate that these highwalls are subject to time-dependent deformation. Field investigations and laboratory physical-properties tests of coal and overburden rocks suggest that several factors influence highwall stability. Some of these factors are rebound of overconsolidated rocks, desiccation, water, orientation and spacing of fractures, and strength and deformation properties. Factors of safety for a typical highwall in the study area (calculated by the finite-element method) may be less than 1.0 when open fractures are present and the highwall has degraded. Although it is concluded that most open-pit mines in the Fort Union Formation within the study area have generally stable highwalls, these highwalls do deteriorate and become progressively less stable. Because of this, postmining failures are common and could be critical if mining were delayed and then resumed after a period of several months. The second part of the investigation will utilize field measurements of rock-mass properties and instrumentation of actively mined highwalls to obtain data for comparison with the results of the initial investigation. Because the height of highwalls will increase as the more shallow coal is exhausted, these data will also be used to predict the behavior of slopes higher than those presently found in the western Powder River Basin.

  16. 75 FR 20859 - Temporary Concession Contract for Blue Ridge Parkway, NC/VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... DEPARTMENT OF THE INTERIOR National Park Service Temporary Concession Contract for Blue Ridge... of temporary concession contract for Blue Ridge Parkway. SUMMARY: Pursuant to 36 CFR 51.24, public... for the conduct of certain visitor services within Blue Ridge Parkway, North Carolina and Virginia for...

  17. Geochemical and mineralogical studies of dinosaur bone from the Morrison Formation at Dinosaur Ridge

    USGS Publications Warehouse

    Modreski, P.J.

    2001-01-01

    The dinosaur bones first discovered in 1877 in the Upper Jurassic Morrison Formation at Morrison, Colorado were the first major find of dinosaur skeletons in the western U.S. and led to the recognition of four new dinosaur genera (Apatosaurus, Allosaurus, Diplodocus, and Stegosaurus). Eight articles dealing with these bones which appeared as research reports in the annual reports of the Friends of Dinosaur Ridge from 1990-1999 are condensed and summarized with some additional comments. Two of the articles are about the mineralogy and preservation of the bones; two are about the physical description of the bone occurrence; two are about the history of the site, and two are about use of novel instrumental methods (ground-penetrating radar and a directional scintillometer) to search for new bones.

  18. Segmentation Control on Crustal Accretion: Insights From the Chile Ridge

    NASA Astrophysics Data System (ADS)

    Martinez, F.; Karsten, J. L.; Milman, M. S.; Klein, E. M.

    2002-12-01

    Controls on crustal accretion at mid-ocean ridges include spreading rate and mantle temperature and composition. Less studied is the effect of the segmentation geometry, although it has been known for some time that large offset transforms have significant effects on the extent of melting and lava compositions produced by ridges in their vicinity. The PANORAMA 4 expedition surveyed the Chile Ridge between 36°-43°S in order to examine the effects of ridge segmentation on crustal accretion. This section of the ridge is spreading uniformly at intermediate rates (~53 mm/yr) and rock sampling and regional data indicate a largely uniform mantle composition with no systematic changes in mantle thermal structure. Thus the segmentation geometry is the primary crustal accretion variable. The survey mapped and sampled 19 first order ridge segments and their transform offsets. The ridges range from 130 to 10 km in length with mapped transform offsets from 168 to 19 km. The segments primarily have axial valley morphology, with segments longer than ~65 km typically displaying central highs deepening toward segment ends. Mantle Bouguer anomalies (MBAs) show that these segments also have bulls eye lows associated with the central highs indicating thicker crust than at segment ends. Overall the mapped segments displays a trend of increasing depth and MBA, implying diminishing crustal production, with decreasing segment length and increasing transform offset. We examine the cause of this trend by modeling the mantle flow pattern generated by finite length ridge segments using the Phipps-Morgan and Forsyth (1988) algorithm. The results indicate that at a constant spreading rate mantle upwelling rates are greatest and extend deeper near the segment center, and that for segments that are significantly offset, upwelling rates decrease overall with decreasing segment length. The modeling implies that segmentation itself, even without cooling and lithospheric relief at transforms has a

  19. Effects of Employing Ridge Regression in Structural Equation Models.

    ERIC Educational Resources Information Center

    McQuitty, Shaun

    1997-01-01

    LISREL 8 invokes a ridge option when maximum likelihood or generalized least squares are used to estimate a structural equation model with a nonpositive definite covariance or correlation matrix. Implications of the ridge option for model fit, parameter estimates, and standard errors are explored through two examples. (SLD)

  20. Appearance of De Geer moraines in southern and western Finland - Implications for reconstructing glacier retreat dynamics

    NASA Astrophysics Data System (ADS)

    Ojala, Antti E. K.

    2016-02-01

    LiDAR digital elevation models (DEMs) from southern and western Finland were investigated to map and discriminate features of De Geer moraines, sparser and more scattered end moraines, and larger end moraine features (i.e., ice-marginal complexes). The results indicate that the occurrence and distribution of De Geer moraines and scattered end moraine ridges in Finland are more widespread than previously suggested. This is probably attributed to the ease of detecting and mapping these features with high-resolution DEMs, indicating the efficiency of LiDAR applications in geological and geomorphological studies. The variable appearance and distribution of moraine ridges in Finland support previous interpretations that no single model is likely to be appropriate for the genesis of De Geer moraines at all localities and for all types of end moraines. De Geer moraine appearances and interdistances probably result from a combination of the general rapidity of ice-margin recession during deglaciation, the proglacial water depth in which they were formed, and local glacier dynamics related to climate and terrain topography. The correlation between the varved clay-based rate of deglaciation and interdistances of distinct and regularly spaced De Geer moraine ridges indicates that the rate of deglaciation is probably involved in the De Geer ridge-forming process, but more thorough comparisons are needed to understand the extent to which De Geer interdistances represent an annual rate of ice-margin decay and the rapidity of regional deglaciation.

  1. Evaluation of Calendar Year 1997 Groundwater and Surface Water Quality Data For The Chestnut Ridge Hydrogeologic Regime At The U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jones, S.B.

    1998-09-01

    This report presents an evaluation of the groundwater monitoring data obtained in the Chestnut Ridge Hydrogeologic Regime (Chestnut Ridge Regime) during calendar year (CY) 1997. The Chestnut Ridge Regime encompasses a section of Chestnut Ridge bordered by the U.S. Department of Energy (DOE) Y-12 Plant in Bear Creek Valley (BCV) to the north, Scarboro Road to the eas~ Bethel Valley Road to the south, and an unnamed drainage basin southwest of the Y-12 Plant (Figure 1). Groundwater quality monitoring is performed at hazardous and nonhazardous waste management facilities in the regime under the auspices of the Y-12 Plant Groundwater Protectionmore » Program (GWPP). The CY 1997 monitoring data are presented in Calendar Year 1997 Annual Groundwater Monitoring Report for the Chestnut Ridge Hydrogeolo~"c Regime at the US. Department of Energy Y-12 Plant, Oak Ridge, Tennessee (MA Technical Services, Inc. 1998), which also presents results of site-specific monitoring data evaluations required under the Resource Conservation and Recovery Act (RCIL4) post-closure permit (PCP) for the Chestnut Ridge Regime« less

  2. Cenozoic Circulation History of the North Atlantic Ocean From Seismic Stratigraphy of the Newfoundland Ridge Drift Complex

    NASA Astrophysics Data System (ADS)

    Boyle, P. R.; Romans, B.; Norris, R. D.; Tucholke, B. E.; Swift, S. A.; Sexton, P. F.

    2014-12-01

    In the North Atlantic Ocean, contour-following bottom currents have eroded regional unconformities and deposited contourite drifts that exceed two km in thickness and extend for 100s of km. The character of deep-water masses that are conveyed through ocean basins by such currents influence global heat transfer and ocean-atmosphere partitioning of CO2. The Newfoundland Ridge Drift Complex lies directly under the modern Deep Western Boundary Current southeast of Newfoundland, close to the site of overturning in the northwest Atlantic Ocean and at the intersection of the warm Gulf Stream and cool Labrador surface currents. To the south are regions of the western North Atlantic basin that are influenced by southern- as well as northern-sourced bottom waters. Here, we document the evolution of North Atlantic deep-water circulation by seismic-stratigraphic analysis of the long-lived and areally extensive Newfoundland Ridge Drift Complex. IODP Expedition 342 boreholes provide age control on seismic units, allowing sedimentation patterns to be placed in a temporal framework. We find three major phases of sedimentation: pre-contourite drift (~115-50 Ma), active contourite drift (~50-2.6 Ma), and late-contourite drift (~2.6-0 Ma). Bottom-current-controlled deposition of terrigenous-rich sediment began at ~50 Ma, which correlates to the onset of a long-term global cooling trend. A further change in deep circulation near the Eocene-Oligocene transition (~30 Ma) is indicated by more focused drift sedimentation with greatly increased accumulation rates and stratal architecture dominated by mud waves. At ~2.6 Ma to present the axis of drift accumulation shifted markedly towards shallower water depths, corresponding with the onset of Northern Hemisphere ice sheets. We discuss how these reorganizations of deep circulation correlate with results of other North Atlantic seismic stratigraphic studies to the north and south.

  3. Late to middle Pleistocene Arctic glacial history implied from a sedimentary record from the Northwind Ridge

    NASA Astrophysics Data System (ADS)

    Liu, Y.; Dong, L.; Shi, X.; Zhu, A.

    2017-12-01

    Abstract: Sediment core ARC6-C21 collected from the Northwind Ridge, western Arctic Ocean, covers the late to middle Quaternary (Marine Isotope Stages (MIS) 1-11), as estimated by correlation to earlier proposed Arctic Ocean stratigraphies and AMS14C dating of the youngest sediments. Detailed examination of the elemental composition of sediment along with grain size in core ARC6-C21 provides important new information about sedimentary environments and provenance. We use increased contents of coarse debris as an indicator of glacier collapse events at the margins of the western Arctic Ocean, and identify the provenance of these events from geochemical composition. Notably, peaks of MgO and CaO, including large dropstones, presumably track the Laurentide Ice Sheet (LIS) discharge events to the Arctic Ocean. Major LIS inputs occurred during the stratigraphic intervals estimated as MIS 3, intra-MIS 5 and 7 events, MIS 8, and MIS 10. Inputs from the East Siberian Ice Sheet (ESIS) and/or Eurasia Ice Sheet (EIS)are inferred from peaks of SiO2, K2O and Na2O associated with coarse sediment. Major ESIS and/or EIS sedimentary events occurred in the intervals estimated as MIS 2, MIS 4, MIS 6, MIS 8 and MIS 10. Keywords: Sediment core, Pleistocene, western Arctic Ocean, geochemistry, grain size, sediment provenance, glaciations

  4. Martian Wrinkle Ridge Topography: Evidence for Subsurface Faults from MOLA

    NASA Technical Reports Server (NTRS)

    Golombek, M. P.; Anderson, F. S.; Zuber, M. T.

    2000-01-01

    Mars Orbiter Laser Altimeter (MOLA) profiles across wrinkle ridges are characterized by plains surfaces at different elevations on either side that appear best explained by subsurface thrust faults that underlie the ridges and produce the offset.

  5. The response of excess 230Th and extraterrestrial 3He to sediment redistribution at the Blake Ridge, western North Atlantic

    NASA Astrophysics Data System (ADS)

    McGee, David; Marcantonio, Franco; McManus, Jerry F.; Winckler, Gisela

    2010-10-01

    The constant-flux proxies excess 230Th ( 230Th xs) and extraterrestrial 3He ( 3He ET) are commonly used to calculate sedimentary mass accumulation rates and to quantify lateral advection of sediment at core sites. In settings with significant lateral input or removal of sediment, these calculations depend on the assumption that concentrations of 230Th xs and 3He ET are the same in both advected sediment and sediment falling through the water column above the core site. Sediment redistribution is known to fractionate grain sizes, preferentially transporting fine grains; though relatively few studies have examined the grain size distribution of 230Th xs and 3He ET, presently available data indicate that both are concentrated in fine grains, suggesting that fractionation during advection may bias accumulation rate and lateral advection estimates based on these proxies. In this study, we evaluate the behavior of 230Th xs and 3He ET in Holocene and last glacial samples from two cores from the Blake Ridge, a drift deposit in the western North Atlantic. At the end of the last glacial period, both cores received large amounts of laterally transported sediment enriched in fine-grained material. We find that accumulation rates calculated by normalization to 230Th and 3He are internally consistent despite large spatial and temporal differences in sediment advection. Our analyses of grain size fractions indicate that ~ 70% of 3He ET-bearing grains are in the < 20 μm fraction, with roughly equal amounts in the < 4 and 4-20 μm fractions. 230Th xs is concentrated in <4-μm grains relative to 4- to 20-μm grains by approximately a factor of 2 in Holocene samples and by a much larger factor (averaging a factor of 10) in glacial samples. Despite these enrichments of both constant-flux proxies in fine particles, the fidelity of 230Th- and 3He-based accumulation rate estimates appears to be preserved even in settings with extreme sediment redistribution, perhaps due to the cohesive

  6. Testing models for the formation of the equatorial ridge on Iapetus via crater counting

    NASA Astrophysics Data System (ADS)

    Damptz, Amanda L.; Dombard, Andrew J.; Kirchoff, Michelle R.

    2018-03-01

    Iapetus's equatorial ridge, visible in global views of the moon, is unique in the Solar System. The formation of this feature is likely attributed to a key event in the evolution of Iapetus, and various models have been proposed as the source of the ridge. By surveying imagery from the Cassini and Voyager missions, this study aims to compile a database of the impact crater population on and around Iapetus's equatorial ridge, assess the relative age of the ridge from differences in cratering between on ridge and off ridge, and test the various models of ridge formation. This work presents a database that contains 7748 craters ranging from 0.83 km to 591 km in diameter. The database includes the study area in which the crater is located, the latitude and longitude of the crater, the major and minor axis lengths, and the azimuthal angle of orientation of the major axis. Analysis of crater orientation over the entire study area reveals that there is no preference for long-axis orientation, particularly in the area with the highest resolution. Comparison of the crater size-frequency distributions show that the crater distribution on the ridge appears to be depleted in craters larger than 16 km with an abruptly enhanced crater population less than 16 km in diameter up to saturation. One possible interpretation is that the ridge is a relatively younger surface with an enhanced small impactor population. Finally, the compiled results are used to examine each ridge formation hypothesis. Based on these results, a model of ridge formation via a tidally disrupted sub-satellite appears most consistent with our interpretation of a younger ridge with an enhanced small impactor population.

  7. The crustal structure of the Cocos ridge off Costa Rica

    NASA Astrophysics Data System (ADS)

    Walther, Christian H. E.

    2003-03-01

    The submarine Cocos ridge in the northwestern Panamá basin, a bathymetric feature more than 1000-km long and 250-500 km broad, is about 2 km shallower than the adjacent basin. It is generally interpreted as the trace of the Galápagos hot spot. Two 127- and 260-km long seismic wide-angle sections were recorded along and across this ridge, offshore the Osa peninsula, Costa Rica. Crustal thickening is seen everywhere along the sections. On the northwestern outer ridge flank, increased thickness is exclusively attributed to the upper crust and expressed by 2-km thick flow basalts. The Quepos plateau caps the upper crust in this area. Toward the center of the Cocos ridge, the Moho deepens from 11-12 to 21 km depth and crustal thickening is almost entirely attributed to the lower crust which makes up 80% of the crust and is three times the thickness of normal oceanic lower crust. It is homogeneously structured and the velocities which range from 6.5 km/s at the top to 7.35 km/s at the base are comparable to normal lower crust under these depth conditions and suggest no differences to a gabbroic rock composition. Similarities to the crustal velocity structure of Iceland, central Kerguelen plateau, and Broken ridge are consistent with a formation of this 13-15 Ma old Cocos ridge segment by excessive magmatism in a near-plate boundary setting.

  8. Recent tectonics of the Mediterranean Ridge

    NASA Astrophysics Data System (ADS)

    Chamot-Rooke, N.; Rangin, C.; Kreemer, C.; Le Pichon, X.; Nielsen, C.; Pascal, G.; Rabaute, A.

    2003-04-01

    The present-day Eastern Mediterranean Sea is shaped by the progressive subduction of the deep Ionian, Herodotus and Levantine basins, all Mesozoic relics of the former Neo-Tethys Ocean. During the last decade, two major inputs improved our understanding of the tectonics of the area. On-land, extensive geodetic surveys confirmed that the recent kinematics involves slow northward motion of Africa with respect to Eurasia and rapid escape of the Anatolia microplate pushed aside by collision of Arabia along the Bitlis-Zagros suture. Offshore, geological and geophysical surveys revealed that continental fragments forming the rigid buttress, or backstop, onto which the Mediterranean Ridge is being built, floor part of the deep Mediterranean Sea. The rate of incorporation of Africa bearing sediments into the Mediterranean wedges (Calabrian prism and Mediterranean Ridge) is tightly controlled by upper plates motions (Calabria and Anatolia) with respect to Africa. The two wedges are presently growing at contrasting rates. Calabria has little motion whereas Anatolia/Aegea is rapidly rotating counterclockwise, implying high subduction rate off Peloponnesus and Crete. The space available for the wedges to grow is in turn controlled by the location and geometry of the leading edge of the Calabria and Anatolia/Aegea blocks, as well as the margin geometry of the northern African border. We discuss here the outline, structure and origin of the backstop in the light of recently acquired deep marine data: multibeam bathymetry, bottom reflectivity, deep seismic, gravity and magnetism. Based on a new mapping of the main active faults at sea combined with a new model of the crustal velocity field over the Eastern Mediterranean constrained by GPS, we show that shearing is essentially active at the wedge-backstop contact. Detailed mapping of a narrow, 500-km long belt of active mud volcanism offshore Peloponnesus and Crete, further shows that the wedge-backstop contact is also a major

  9. Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.

    PubMed

    Du, Xianhong; Wu, Zhuanchang; Xu, Yong; Liu, Yuan; Liu, Wen; Wang, Tixiao; Li, Chunyang; Zhang, Cuijuan; Yi, Fan; Gao, Lifen; Liang, Xiaohong; Ma, Chunhong

    2018-05-07

    As an immune checkpoint, Tim-3 plays roles in the regulation of both adaptive and innate immune cells including macrophages and is greatly involved in chronic liver diseases. However, the precise roles of Tim-3 in nonalcoholic steatohepatitis (NASH) remain unstated. In the current study, we analyzed Tim-3 expression on different subpopulations of liver macrophages and further investigated the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice. The results of flow cytometry demonstrated the significantly increased expression of Tim-3 on all detected liver macrophage subsets in MCD mice, including F4/80 + CD11b + , F4/80 + CD68 + , and F4/80 + CD169 + macrophages. Remarkably, Tim-3 knockout (KO) significantly accelerated MCD-induced liver steatosis, displaying higher serum ALT, larger hepatic vacuolation, more liver lipid deposition, and more severe liver fibrosis. Moreover, compared with wild-type C57BL/6 mice, Tim-3 KO MCD mice demonstrated an enhanced expression of NOX2, NLRP3, and caspase-1 p20 together with increased generation of IL-1β and IL-18 in livers. In vitro studies demonstrated that Tim-3 negatively regulated the production of reactive oxygen species (ROS) and related downstream pro-inflammatory cytokine secretion of IL-1β and IL-18 in macrophages. Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD. In conclusion, Tim-3 is a promising protector in MCD-induced steatohepatitis by controlling ROS and the associated pro-inflammatory cytokine production in macrophages.

  10. Paraoxonase 1 and oxidative stress in paediatric non-alcoholic steatohepatitis.

    PubMed

    Desai, Sonal; Baker, Susan S; Liu, Wensheng; Moya, Diana A; Browne, Richard W; Mastrandrea, Lucy; Baker, Robert D; Zhu, Lixin

    2014-01-01

    Non-alcoholic steatohepatitis (NASH) in children is a significant public health concern. Oxidative stress is an important component in the pathophysiology of NASH. Several enzymatic antioxidant mechanisms protect the liver from oxidative injury. Examination of the expression of these enzymes in NASH livers may provide insight on the roles for these antioxidant mechanisms in the pathophysiology of NASH. The mRNA expression of catalase, glutathione peroxidase 1 (GPX1), glutathione reductase (GSR), paraoxonase 1 (PON1) and other reactive oxygen species-related genes was evaluated by microarray and quantitative real-time PCR analyses. The PON1 protein levels were evaluated in liver and serum by Western blot analyses. Serum enzymatic activities of GPX, GSR and PON1 (paraoxonase and arylesterase activities) were examined. NASH livers exhibited elevated mRNA expression of catalase and PON1, but not GPX1 or GSR. No difference in serum GPX or GSR activity was detected between NASH patients and controls. Elevated expression of PON1 mRNA and protein was detected in NASH livers, but serum PON1 protein and activities were not elevated. Elevated expression of catalase and PON1 suggests protective roles for these antioxidants in NASH livers. Given the importance of oxidative stress in the pathophysiology of NASH, future studies focusing on these enzymes could identify important targets for therapeutic or preventive interventions for NASH patients. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Seismic imaging of the Formosa Ridge cold seep site offshore of southwestern Taiwan

    NASA Astrophysics Data System (ADS)

    Hsu, Ho-Han; Liu, Char-Shine; Morita, Sumito; Tu, Shu-Lin; Lin, Saulwood; Machiyama, Hideaki; Azuma, Wataru; Ku, Chia-Yen; Chen, Song-Chuen

    2017-12-01

    Multi-scale reflection seismic data, from deep-penetration to high-resolution, have been analyzed and integrated with near-surface geophysical and geochemical data to investigate the structures and gas hydrate system of the Formosa Ridge offshore of southwestern Taiwan. In 2007, dense and large chemosynthetic communities were discovered on top of the Formosa Ridge at water depth of 1125 m by the ROV Hyper-Dolphin. A continuous and strong BSR has been observed on seismic profiles from 300 to 500 ms two-way-travel-time below the seafloor of this ridge. Sedimentary strata of the Formosa Ridge are generally flat lying which suggests that this ridge was formed by submarine erosion processes of down-slope canyon development. In addition, some sediment waves and mass wasting features are present on the ridge. Beneath the cold seep site, a vertical blanking zone, or seismic chimney, is clearly observed on seismic profiles, and it is interpreted to be a fluid conduit. A thick low velocity zone beneath BSR suggests the presence of a gas reservoir there. This "gas reservoir" is shallower than the surrounding canyon floors along the ridge; therefore as warm methane-rich fluids inside the ridge migrate upward, sulfate carried by cold sea water can flow into the fluid system from both flanks of the ridge. This process may drive a fluid circulation system and the active cold seep site which emits both hydrogen sulfide and methane to feed the chemosynthetic communities.

  12. Ridging and strength in modeling the thickness distribution of Arctic sea ice

    NASA Astrophysics Data System (ADS)

    Flato, Gregory M.; Hibler, William D.

    1995-09-01

    A theory describing evolution of the ice thickness distribution (the probability density of ice thickness) was proposed by Thorndike et al. (1975) and has been used in several sea ice models. The advantage of this theory over the widely used two-level formulation is that it treats ridging explicitly as a redistribution of ice thickness, and ice strength as a function of energy losses incurred by ridge formation. However, the parameterization of these processes remains rather speculative and largely untested, and so our purpose here is to explore these parameterizations using a numerical model based on this theory. The model uses a 160-km resolution grid of the Arctic and 7 years of observed atmospheric forcing data (1979-1985). Monthly oceanic heat flux and current fields are obtained from a 40-km resolution coupled ice-ocean model run separately with the same forcing. By requiring the computed monthly mean ice drift to have the same magnitude as observed buoy drift, we estimate the primary strength parameter: the ratio of total to potential energy change during ridging. This ratio depends on the value of other parameters; however, the standard case has a ratio of 17 which is within the range estimated by Hopkins (1994) in simulations of individual ridging events. The effects of ridge redistribution and shear ridging parameters are illustrated by a series of sensitivity studies and comparisons between observed and modeled ice thickness distributions and ridge statistics. In addition, these comparisons highlight the following shortcomings of the thickness distribution theory as it is presently implemented: first, the process of first-year to multiyear ridge consolidation is ignored; and second, the observed preferential melt of thick ridged ice is not reproduced.

  13. Micro-imager View: Layers in 'Vera Rubin Ridge,' Mars

    NASA Image and Video Library

    2017-09-13

    This view of "Vera Rubin Ridge" from the Chemistry and Camera (ChemCam) instrument on NASA's Curiosity Mars rover shows multiple sedimentary layers and fracture-filling deposits of minerals. Buried layers of what is now a ridge became fractured, and the fractures were filled with mineral deposits precipitated from underground fluids that moved through the fractures. ChemCam's telescopic Remote Micro-Imager took the 10 component images of this mosaic on July 3, 2017, during the 1,745th Martian day, or sol, of Curiosity's work on Mars. The camera was about 377 feet (115 meters) away from the pictured portion of the ridge. The rover's location at the time, shown in a Sol 1741 traverse map, was west of the place where it began its ascent up the ridge about two months later. The scale bar at lower right indicates how wide a feature 9 inches (22.8 centimeters) in width would look in the middle portion of the scene. https://photojournal.jpl.nasa.gov/catalog/PIA21852

  14. Ridges and Flows

    NASA Image and Video Library

    2015-11-16

    Located southwest of Olympus Mons, this image captured by NASA 2001 Mars Odyssey spacecraft shows part of a complex region that has undergone several geologic processes. The hills have been modified by wind, creating narrow ridges, and then the entire region has been covered with volcanic flows from Olympus Mons. Orbit Number: 60744 Latitude: 13.4267 Longitude: 220.554 Instrument: VIS Captured: 2015-08-24 10:00 http://photojournal.jpl.nasa.gov/catalog/PIA20093

  15. Building of tropical beach ridges, northeastern Queensland, Australia: Cyclone inundation and aeolian decoration

    NASA Astrophysics Data System (ADS)

    Tamura, Toru; Nicholas, William; Brooke, Brendan; Oliver, Thomas

    2016-04-01

    Processes associated with tropical cyclones are thought responsible for building coarse sand beach ridges along the northeastern Queensland coast, Australia. While these ridges are expected to be geological records of the past cyclone, they question the general consensus of the aeolian genesis of sandy beach ridges. To explore the ridge-forming process, we carried out the GPR survey, auger drilling, pit excavation, grain-size analysis, and OSL dating for coarse sand beach ridges at the Cowley Beach, northeastern Queensland. The Cowley Beach is a mesotidal beach characterized by a low-tide terrace and steep beach face. Ten beach ridges are recognized along the survey transect that extends 700 m inland from the shore. 37 OSL ages are younger seawards, indicating the seaward accretion of the ridge sequence over the last 2700 years. The highest ridge is +5.1 m high above AHD (Australian Height Datum). Two GPR units are bounded by a groundwater surface at c. +1.5 m AHD. The upper unit is characterized by horizontal to hummocky reflectors punctuated by seaward dipping truncation surfaces. These reflectors in places form dome-like structure that appears to be the nucleus of a beach ridge. The shape and level (+2.5 m AHD) of the dome are similar to those of the present swash berm. The lower unit shows a sequence of reflectors that dip at an angle of present beach face. The sequence is dissected by truncation surfaces, some of which are continuous to those in the upper unit. Coarse sand mainly forms beach ridge deposits below +4.0 m AHD, while a few higher ridges have an upward fining layer composed of medium sand above +4.0 m, which is finer than aeolian ripples found on the backshore during the survey. In addition, pumice gravel horizons underlie the examined ridge crests. The sequence of seaward dipping reflectors indicates that the Cowley Beach, like other many sandy beaches, has prograded during onshore sand accretion by fairweather waves and has been eroded by storms

  16. Holifield Heavy-Ion Research Facility at Oak Ridge

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jones, C.M.

    1977-01-01

    A new heavy-ion accelerator facility is now under construction at the Oak Ridge National Laboratory. A brief description of the scope and schedule of this project is given, and the new large tandem accelerator, which will be a major element of the facility is discussed in some detail. Several studies which have been made or are in progress in Oak Ridge in preparation for operation of the tandem accelerator are briefly described.

  17. Mid Ocean Ridge Processes at Very Low Melt Supply : Submersible Exploration of Smooth Ultramafic Seafloor at the Southwest Indian Ridge, 64 degree E

    NASA Astrophysics Data System (ADS)

    Cannat, M.; Agrinier, P.; Bickert, M.; Brunelli, D.; Hamelin, C.; Lecoeuvre, A.; Lie Onstad, S.; Maia, M.; Prampolini, M.; Rouméjon, S.; Vitale Brovarone, A.; Besançon, S.; Assaoui, E. M.

    2017-12-01

    Mid-ocean ridges are the Earth's most extensive and active volcanic chains. They are also, particularly at slow spreading rates, rift zones, where plate divergence is in part accommodated by faults. Large offset normal faults, also called detachments, are characteristic of slow-spreading ridges, where they account for the widespread emplacement of mantle-derived rocks at the seafloor. In most cases, these detachments occur together with ridge magmatism, with melt injection and faulting interacting to shape the newly formed oceanic lithosphere. Here, we seek to better understand these interactions and their effects on oceanic accretion by studying the end-member case of a ridge where magmatism is locally almost absent. The portion of the Southwest Indian ridge we are studying has an overal low melt supply, focused to discrete axial volcanoes, leaving almost zero melt to intervening sections of the axial valley. One of these nearly amagmatic section of the ridge, located at 64°E, has been the focus of several past cruises (sampling, mapping and seismic experiments). Here we report on the most recent cruise to the area (RV Pourquoi Pas? with ROV Victor; dec-jan 2017), during which we performed high resolution mapping, submersible exploration and sampling of the ultramafic seafloor and of sparse volcanic formations. Our findings are consistent with the flip-flop detachment hypothesis proposed for this area by Sauter et al. (Nature Geosciences, 2013; ultramafic seafloor forming in the footwall of successive detachment faults, each cutting into the footwall of the previous fault, with an opposite polarity). Our observations also document the extent and geometry of deformation in the footwall of a young axial detachment, the role of mass-wasting for the evolution of this detachment, and provide spectacular evidence for serpentinization-related hydrothermal circulation and for spatial links between faults and volcanic eruptions.

  18. Curiosity at Vera Rubin Ridge: Testable Hypotheses, First Results, and Implications for Habitability

    NASA Astrophysics Data System (ADS)

    Fraeman, A.; Bedford, C.; Bridges, J.; Edgar, L. A.; Hardgrove, C.; Horgan, B. H. N.; Gabriel, T. S. J.; Grotzinger, J. P.; Gupta, S.; Johnson, J. R.; Rampe, E. B.; Morris, R. V.; Salvatore, M. R.; Schwenzer, S. P.; Stack, K.; Pinet, P. C.; Rubin, D. M.; Weitz, C. M.; Wellington, D. F.; Wiens, R. C.; Williams, A. J.; Vasavada, A. R.

    2017-12-01

    As of sol 1756, Curiosity was 250 meters from ascending Vera Rubin Ridge, a unique geomorphic feature preserved in the lower foothills of Aeolis Mons (informally known as Mt. Sharp) that is distinguishable from orbit. Vera Rubin Ridge (previously termed the Hematite Ridge) is characterized by a higher thermal inertia than the surrounding terrain, is comparatively resistant to erosion, and is capped with a hematite-bearing layer that is visible in 18 m/pixel CRISM data. A key hypothesis associated with this unit is that it represents a redox interface where ferrous iron oxidized and precipitated either as hematite or another ferric precursor. The Curiosity integrated payload is being used to determine the depositional environment(s), stratigraphic context and geochemical conditions associated with this interface, all of which will provide key insights into its past habitability potential and the relative timing of processes. Specifically, analysis of Curiosity data will address four major questions related to the history and evolution of ridge-forming strata: (1) What is the stratigraphic relationship between the units in the ridge and the Mt. Sharp group (see Grotzinger et al., 2015)? (2) What primary and secondary geologic processes deposited and modified the ridge units over time? (3) What is the nature and timing of the hematite precipitation environment, and how does it relate to similar oxidized phases in the Murray formation? (4) What are the implications for habitability and the preservation of organic molecules? Initial results of a systematic imaging campaign along the contact between the lower portion or the ridge and the Murray formation has revealed dm-scale cross bedding within the ridge stratigraphy, which provide clues about the depositional environments; these can be compared to suites of sedimentary structures within the adjacent Murray formation. Long distance ChemCam passive and Mastcam multispectral data show that hematite and likely other

  19. Reproduction and seasonal activity of silver-haired bats (Lasionycteris noctivagans) in western Nebraska

    USGS Publications Warehouse

    Geluso, Keith; Huebschman, J.J.; White, J.A.; Bogan, M.A.

    2004-01-01

    Silver-haired bats (Lasionycteris noctivagans) were thought only to migrate through Nebraska; however, recent surveys in eastern Nebraska report summer records of females and their young. Our study in western Nebraska also shows that silver-haired bats are summer residents. We discovered the 1st reproductively active L. noctivagans in this part of the state. We caught lactating females and volant young in riparian forests along the North Platte River and in forested areas of the Pine Ridge. Previously, adult males were not known from Nebraska in summer, and only 4 records of L. noctivagans were known from western Nebraska during migration. On 28 July we captured an adult male in a coniferous forest of the Wildcat Hills, and we have more than 100 records of migrating individuals. Lastly, an obese L. noctivagans captured on 4 November may represent an individual preparing to hibernate in the state.

  20. Ridge-like lava tube systems in southeast Tharsis, Mars

    NASA Astrophysics Data System (ADS)

    Zhao, Jiannan; Huang, Jun; Kraft, Michael D.; Xiao, Long; Jiang, Yun

    2017-10-01

    Lava tubes are widely distributed in volcanic fields on a planetary surface and they are important means of lava transportation. We have identified 38 sinuous ridges with a lava-tube origin in southeast Tharsis. The lengths vary between 14 and 740 km, and most of them occur in areas with slopes < 0.3°. We analyzed their geomorphology in detail with CTX (Context Camera) and HiRISE (High Resolution Imaging Science Experiment) images and DTM (digital terrain model) derived from them. We identified three cross-sectional shapes of these sinuous ridges: round-crested, double-ridged, and flat-crested and described features associated with the lava tubes, including branches, axial cracks, collapsed pits, breakout lobes, and tube-fed lava deltas. Age determination results showed that most of the lava tubes formed in Late Hesperian and were active until the Hesperian-Amazonian boundary. We proposed that these lava tubes formed at relatively low local flow rate, low lava viscosity, and sustained magma supply during a long period. Besides, lava flow inflation is also important in the formation of the ridge-like lava tubes and some associated features. These lava tubes provide efficient lateral pathways for magma transportation over the relatively low topographic slopes in southeast Tharsis, and they are important for the formation of long lava flows in this region. The findings of this study provide an alternative formation mechanism for sinuous ridges on the martian surface.

  1. Hydrodynamic role of longitudinal dorsal ridges in a leatherback turtle swimming

    NASA Astrophysics Data System (ADS)

    Bang, Kyeongtae; Kim, Jooha; Lee, Sang-Im; Choi, Haecheon

    2016-10-01

    Leatherback sea turtles (Dermochelys coriacea) are known to have a superior diving ability and be highly adapted to pelagic swimming. They have five longitudinal ridges on their carapace. Although it was conjectured that these ridges might be an adaptation for flow control, no rigorous study has been performed to understand their hydrodynamic roles. Here we show that these ridges are slightly misaligned to the streamlines around the body to generate streamwise vortices, and suppress or delay flow separation on the carapace, resulting in enhanced hydrodynamic performances during different modes of swimming. Our results suggest that shapes of some morphological features of living creatures, like the longitudinal ridges of the leatherback turtles, need not be streamlined for excellent hydro- or aerodynamic performances, contrary to our common physical intuition.

  2. Near-ridge seamount chains in the northeastern Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Clague, David A.; Reynolds, Jennifer R.; Davis, Alicé S.

    2000-07-01

    High-resolution bathymetry and side-scan data of the Vance, President Jackson, and Taney near-ridge seamount chains in the northeast Pacific were collected with a hull-mounted 30-kHz sonar. The central volcanoes in each chain consist of truncated cone-shaped volcanoes with steep sides and nearly flat tops. Several areas are characterized by frequent small eruptions that result in disorganized volcanic regions with numerous small cones and volcanic ridges but no organized truncated conical structure. Several volcanoes are crosscut by ridge-parallel faults, showing that they formed within 30-40 km of the ridge axis where ridge-parallel faulting is still active. Magmas that built the volcanoes were probably transported through the crust along active ridge-parallel faults. The volcanoes range in volume from 11 to 187 km3, and most have one or more multiple craters and calderas that modify their summits and flanks. The craters (<1 km diameter) and calderas (>1 km diameter) range from small pit craters to calderas as large as 6.5×8.5 km, although most are 2-4 km across. Crosscutting relationships commonly show a sequence of calderas stepping toward the ridge axis. The calderas overlie crustal magma chambers at least as large as those that underlie Kilauea and Mauna Loa Volcanoes in Hawaii, perhaps 4-5 km in diameter and ˜1-3 km below the surface. The nearly flat tops of many of the volcanoes have remnants of centrally located summit shields, suggesting that their flat tops did not form from eruptions along circumferential ring faults but instead form by filling and overflowing of earlier large calderas. The lavas retain their primitive character by residing in such chambers for only short time periods prior to eruption. Stored magmas are withdrawn, probably as dikes intruded into the adjacent ocean crust along active ridge-parallel faults, triggering caldera collapse, or solidified before the next batch of magma is intruded into the volcano, probably 1000-10,000 years

  3. The response of the southwest Western Australian wave climate to Indian Ocean climate variability

    NASA Astrophysics Data System (ADS)

    Wandres, Moritz; Pattiaratchi, Charitha; Hetzel, Yasha; Wijeratne, E. M. S.

    2018-03-01

    Knowledge of regional wave climates is critical for coastal planning, management, and protection. In order to develop a regional wave climate, it is important to understand the atmospheric systems responsible for wave generation. This study examines the variability of the southwest Western Australian (SWWA) shelf and nearshore wind wave climate and its relationship to southern hemisphere climate variability represented by various atmospheric indices: the southern oscillation index (SOI), the Southern Annular Mode (SAM), the Indian Ocean Dipole Mode Index (DMI), the Indian Ocean Subtropical Dipole (IOSD), the latitudinal position of the subtropical high-pressure ridge (STRP), and the corresponding intensity of the subtropical ridge (STRI). A 21-year wave hindcast (1994-2014) of the SWWA continental shelf was created using the third generation wave model Simulating WAves Nearshore (SWAN), to analyse the seasonal and inter-annual wave climate variability and its relationship to the atmospheric regime. Strong relationships between wave heights and the STRP and the STRI, a moderate correlation between the wave climate and the SAM, and no significant correlation between SOI, DMI, and IOSD and the wave climate were found. Strong spatial, seasonal, and inter-annual variability, as well as seasonal longer-term trends in the mean wave climate were studied and linked to the latitudinal changes in the subtropical high-pressure ridge and the Southern Ocean storm belt. As the Southern Ocean storm belt and the subtropical high-pressure ridge shifted southward (northward) wave heights on the SWWA shelf region decreased (increased). The wave height anomalies appear to be driven by the same atmospheric conditions that influence rainfall variability in SWWA.

  4. Oak Ridge Reservation Physical Characteristics and Natural Resources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Parr, P.D.; Hughes, J.F.

    The topography, geology, hydrology, vegetation, and wildlife of the Oak Ridge Reservation (ORR) provide a complex and intricate array of resources that directly impact land stewardship and use decisions (Fig. 1). The purpose of this document is to consolidate general information regarding the natural resources and physical characteristics of the ORR. The ORR, encompassing 33,114 acres (13,401 ha) of federally owned land and three Department of Energy (DOE) installations, is located in Roane and Anderson Counties in east Tennessee, mostly within the corporate limits of the city of Oak Ridge and southwest of the population center of Oak Ridge. Themore » ORR is bordered on the north and east by the population center of the city of Oak Ridge and on the south and west by the Clinch River/Melton Hill Lake impoundment. All areas of the ORR are relatively pristine when compared with the surrounding region, especially in the Valley and Ridge Physiographic Province (Fig. 2). From the air, the ORR is clearly a large and nearly continuous island of forest within a landscape that is fragmented by urban development and agriculture. Satellite imagery from 2006 was used to develop a land-use/land-cover cover map of the ORR and surrounding lands (Fig. 3). Following the acquisition of the land comprising the ORR in the early 1940s, much of the Reservation served as a buffer for the three primary facilities: the X-10 nuclear research facility (now known as the Oak Ridge National Laboratory [ORNL]), the first uranium enrichment facility or Y-12 (now known as the Y-12 National Security Complex [Y-12 Complex]), and a gaseous diffusion enrichment facility (now known as the East Tennessee Technology Park [ETTP]). Over the past 60 years, this relatively undisturbed area has evolved into a rich and diverse eastern deciduous forest ecosystem of streams and reservoirs, hardwood forests, and extensive upland mixed forests. The combination of a large land area with complex physical

  5. Feature Selection for Ridge Regression with Provable Guarantees.

    PubMed

    Paul, Saurabh; Drineas, Petros

    2016-04-01

    We introduce single-set spectral sparsification as a deterministic sampling-based feature selection technique for regularized least-squares classification, which is the classification analog to ridge regression. The method is unsupervised and gives worst-case guarantees of the generalization power of the classification function after feature selection with respect to the classification function obtained using all features. We also introduce leverage-score sampling as an unsupervised randomized feature selection method for ridge regression. We provide risk bounds for both single-set spectral sparsification and leverage-score sampling on ridge regression in the fixed design setting and show that the risk in the sampled space is comparable to the risk in the full-feature space. We perform experiments on synthetic and real-world data sets; a subset of TechTC-300 data sets, to support our theory. Experimental results indicate that the proposed methods perform better than the existing feature selection methods.

  6. The Cenozoic western Svalbard margin: sediment geometry and sedimentary processes in an area of ultraslow oceanic spreading

    NASA Astrophysics Data System (ADS)

    Amundsen, Ingrid Marie Hasle; Blinova, Maria; Hjelstuen, Berit Oline; Mjelde, Rolf; Haflidason, Haflidi

    2011-12-01

    The northeastern high-latitude North Atlantic is characterised by the Bellsund and Isfjorden fans on the continental slope off west Svalbard, the asymmetrical ultraslow Knipovich spreading ridge and a 1,000 m deep rift valley. Recently collected multichannel seismic profiles and bathymetric records now provide a more complete picture of sedimentary processes and depositional environments within this region. Both downslope and alongslope sedimentary processes are identified in the study area. Turbidity currents and deposition of glacigenic debris flows are the dominating downslope processes, whereas mass failures, which are a common process on glaciated margins, appear to have been less significant. The slide debrite observed on the Bellsund Fan is most likely related to a 2.5-1.7 Ma old failure on the northwestern Barents Sea margin. The seismic records further reveal that alongslope current processes played a major role in shaping the sediment packages in the study area. Within the Knipovich rift valley and at the western rift flank accumulations as thick as 950-1,000 m are deposited. We note that oceanic basement is locally exposed within the rift valley, and that seismostratigraphic relationships indicate that fault activity along the eastern rift flank lasted until at least as recently as 1.5 Ma. A purely hemipelagic origin of the sediments in the rift valley and on the western rift flank is unlikely. We suggest that these sediments, partly, have been sourced from the western Svalbard—northwestern Barents Sea margin and into the Knipovich Ridge rift valley before continuous spreading and tectonic activity caused the sediments to be transported out of the valley and westward.

  7. Subsidence and volcanism of the Haleakala Ridge, Hawaii

    USGS Publications Warehouse

    Moore, J.G.; Clague, D.A.; Ludwig, K. R.; Mark, R.K.

    1990-01-01

    Side-looking sonar (GLORIA) mapping has revealed a series of four arcuate bands of high sonic backscatter on the crest of the Haleakala Ridge, a major rift-zone ridge extending 135 km east of the island of Maui. Dredge recovery indicates that the shallowest of these bands is a drowned coral reef, and the deeper bands are also inferred to be coral reefs. The reefs occur above a prominent submarine bench 1500-2500 m deep on the ridge (H-terrace) that marks the shoreline at the end of vigorous shield building of Haleakala volcano when lava flows ceased crossing and reworking the shoreline. Since their growth these reefs have subsided as much as 2200 m and have tilted systematically about 20 m/km southward as a result of post-reef volcanic loading on the island of Hawaii, whose center of mass is about directly south of the Haleakala Ridge. The 234U/238U age of the dredged coral is 750 ?? 13 ka, in reasonable agreement with an age of 850 ka for the underlying H terrace previously estimated from its relationship to other dated reefs to the southwest. Basalt glass fragments dredged from the Haleakala Ridge below the H terrace are tholeiitic and contain high sulfur indicative of eruption in water deeper than 200 m. Basalt glass fragments associated with the reefs above the H terrace are dominantly tholeiitic and contain intermediate sulfur contents, indicative of subaqueous eruption in shallow, near-shore conditions. One alkalic glass fragment was recovered above the H terrace. These relations indicate that the morphologic end of shield building as recorded by construction of the H terrace was not accompanyed by a change from tholeiitic to alkalic basalt; instead tholeiite eruptions continued for some time before the erupted lava became alkalic. ?? 1990.

  8. Olivine-Rich Troctolite from the Southwest Indian Ridge: Constrains on Melt-Rock Reaction beneath Mid-Ocean Ridges

    NASA Astrophysics Data System (ADS)

    Yang, A. Y.

    2017-12-01

    The origin of olivine-rich troctolite, which have been recovered in the plutonic sample suites from the fast-spreading East Pacific Rise, and slow-spreading Mid-Atlantic Ridge and Central Indian Ridge, has been highly debated. They can form either by fractionation of primitive mid-ocean ridge basalt (MORB) melts or by melt migrating through pre-existing (possibly mantle) olivine matrix, thus recording valuable information of magmatic process at mantle-crust transition. This study presents in situ major and trace element study on the olivine-rich troctolite first reported from the ultraslow-spreading Southwest Indian Ridge (SWIR), together with a series of samples from peridotite, gabbro to basalt from an amagmatic segment at 53°E during Dayangyihao Cruises, to investigate the magmatic processes occurred at mantle-crust transition and origin of olivine-rich troctolite. The olivine in the troctolite shows cumulate textures with interstitial clinopyroxene, plagioclase and minor spinel, which is cross-cut by an olivine gabbro vein. Olivine in the troctolite show only mildly decreasing NiO contents (from 0.31-0.25 wt.%) with decreasing Fo (from 86 to 81), and even olivine in the gabbro have NiO up to 0.24 wt.% with Fo of 75. The Fo vs. Ni correlation of olivine is shifted to uniquely higher NiO at a certain Fo compared to the trends defined by either olivine from other lower oceanic crust (LOC) cumulates worldwide or olivine compositions from classic fractionation model for primitive MORB magma. Interstitial clinopyroxene in the troctolite have high Mg# (88-90), Cr2O3 (up to 1.51 wt.%) and TiO2 contents (up to 1.01 wt.%) with Eu/Eu* from 0.4-0.6. Such high-Ti-Cr-Mg# clinopyroxene is rare among global LOC cumulates, and cannot result from simple fractionation of MORB magma. The mineral compositions in the olivine-rich troctolite could be modeled by reaction between a primitive olivine matrix and a highly evolved melt (with 2.4 wt.% TiO2), and such a melt composition is

  9. Oak Ridge Reservation Annual Site environmental report summary for 1994

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-09-01

    This document presents a summary of the information collected for the Oak Ridge Reservation 1994 site environmental report. Topics discussed include: Oak Ridge Reservation mission; ecology; environmental laws; community participation; environmental restoration; waste management; radiation effects; chemical effects; risk to public; environmental monitoring; and radionuclide migration.

  10. 133. View of rock cut at base of rough ridge ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    133. View of rock cut at base of rough ridge and roadway crossing unnamed viaduct on Grandfather Mountain with the Great Wall of China supporting the curve in the distance. Looking southeast. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  11. Dielectrophoresis device and method having insulating ridges for manipulating particles

    DOEpatents

    Cummings, Eric B [Livermore, CA; Fiechtner, Gregory J [Livermore, CA

    2008-03-25

    Embodiments of the present invention provide methods and devices for manipulating particles using dielectrophoresis. Insulating ridges and valleys are used to generate a spatially non-uniform electrical field. Particles may be concentrated, separated, or captured during bulk fluid flow in a channel having insulating ridges and valleys.

  12. Development, Testing, and Psychometric Qualities of the Nash Duty to Care Scale for Disaster Response.

    PubMed

    Nash, Tracy Jeanne

    2017-08-01

    Although nurses struggle with the decision to report for work during disaster events, there are no instruments to measure nurses' duty to care for disaster situations. The purpose of this study was to describe the development, testing, and psychometric qualities of the Nash Duty to Care Scale. A convenience sample of 409 registered nurses were recruited from 3 universities in the United States. Exploratory factor analysis resulted in a 19-item, 4-factor model explaining 67.34% of the variance. Internal consistency reliability was supported by Cronbach's alpha ranging from .81 to .91 for the 4-factor subscales and .92 for the total scale. The psychometrically sound instrument for measuring nurses' perceived duty to care for disasters is applicable to contemporary nursing practice, institutional disaster management plans, and patient health outcomes worldwide.

  13. Halogen and trace element geochemistry in Mid-Ocean Ridge basalts from the Australian-Antarctic Ridge (AAR)

    NASA Astrophysics Data System (ADS)

    Yang, Y. S.; Seo, J. H.; Park, S. H.; Kim, T.

    2015-12-01

    Australian-Antarctic Ridge (AAR) is an extension of easternmost SE Indian Mid-Ocean Ridge (MOR).We collected volcanic glasses from the "in-axis" of the KR1 and KR2 MOR, and the overlapping zones of the KR1 MOR and the nearby seamounts ("KR1 mixing"). We determined trace and halogen elements in the glasses. Halogen concentrations and its ratios in the glasses are important to understand the mantle metasomatism and volatile recycling. 52 of the collected glasses are "primitive" (higher than 6 wt% MgO), while 3 of them have rather "evolved" composition (MgO wt% of 1.72, 2.95 and 4.15). K2O concentrations and Th/Sc ratios in the glasses show a negative correlation with its MgO concentration. Incompatible element ratios such as La/Sm are rather immobile during a magma differentiation so the ratios are important to understand mantle composition (Hofmann et al. 2003). La/Sm ratios in the glasses are 0.95 ~ 3.28 suggesting that the AAR basalts can be classified into T-MORB and E-MORB (Schilling et al., 1983). La/Sm ratios are well-correlated with incompatible elements such as U, Ba, Nb, and negatively correlated with compatible elements such as Sc, Eu2+, Mg. The AAR glasses contain detectable halogen elements. The "KR1 mixing" glasses in halogen elements are more abundant than "in-axis" the glasses. Cl is the least variable element compared to the other halogens such as Br and I in the AAR. The "KR1 mixing" glasses have the largest variations of Br/Cl ratios compared to the "in-axis" glasses. The Cl/Br and Th/Sc ratios in the "in-axis" glasses and in the "KR1 mixing" glasses show positive and negative correlations, respectively. The Br-rich glasses in the "KR1 mixing" zone might be explained by a recycled Br-rich oceanic slab of paleo-subduction or by a hydrothermal alteration in the AAR. I composition in the glasses does not show a correlation other trace elements. The K/Cl and K/Ti ratios in the AAR glasses are similar to the basalts from the Galapagos Spreading Center

  14. The Tribolium castaneum Ortholog of Sex combs reduced Controls Dorsal Ridge Development

    PubMed Central

    Shippy, Teresa D.; Rogers, Carmelle D.; Beeman, Richard W.; Brown, Susan J.; Denell, Robin E.

    2006-01-01

    In insects, the boundary between the embryonic head and thorax is formed by the dorsal ridge, a fused structure composed of portions of the maxillary and labial segments. However, the mechanisms that promote development of this unusual structure remain a mystery. In Drosophila, mutations in the Hox genes Sex combs reduced and Deformed have been reported to cause abnormal dorsal ridge formation, but the significance of these abnormalities is not clear. We have identified three mutant allele classes of Cephalothorax, the Tribolium castaneum (red flour beetle) ortholog of Sex combs reduced, each of which has a different effect on dorsal ridge development. By using Engrailed expression to monitor dorsal ridge development in these mutants, we demonstrate that Cephalothorax promotes the fusion and subsequent dorsolateral extension of the maxillary and labial Engrailed stripes (posterior compartments) during dorsal ridge formation. Molecular and genetic analysis of these alleles indicates that the N terminus of Cephalothorax is important for the fusion step, but is dispensable for Engrailed stripe extension. Thus, we find that specific regions of Cephalothorax are required for discrete steps in dorsal ridge formation. PMID:16849608

  15. Ridge Segmentation, Tectonic Evolution and Rheology of Slow-Spreading Oceanic Crust

    DTIC Science & Technology

    1996-09-01

    important source of motivation, information, and geological field trips (remember Canarias , HeMn3’?). Dave Aubrey guided me on my first steps in Woods Hole... volcanic Ruppel, C., and P. Shaw. An elastic plate thickness map of the Mid- segmentation of the Mid-Atlantic Ridge: Kane to Atlantis Fracture Atlantic Ridge...76, 156, 1995. Smith, D. K., J. R. Cann, M. E. Dougherty, J. Lin, J. Keeton, E. McAllister, C. J. MacLeod and S. Spencer, Mid-Atlantic ridge volcanism

  16. Stretching factors in Cenozoic multi-rift basins, western Gulf of Thailand

    NASA Astrophysics Data System (ADS)

    Kaewkor, Chanida; Watkinson, Ian

    2017-04-01

    The Gulf of Thailand (GoT) is the biggest petroleum producing province in Thailand. It is separated by the north-south trending Ko Kra Ridge into two main parts: the Western Area and Basinal Area. A series of horsts and grabens formed by north-south oriented extensional faults subdivides the GoT into a number of basins. The two major basins, Pattani and North Malay, are located in the Basinal Area that contains the main oil and gas fields. The Western Area comprises several smaller and shallower basins but has nonetheless resulted in commercial successes, including oil fields such as Nang Nuan (Chumphon Basin), Bualuang (Western Basin) and Songkhla (Songkhla Basin). The GoT is one of several unusual Cenozoic basins within Sundaland, the continental core of SE Asia. These basins have previously been characterized by multiple distinct phases of extension and inversion, rapid post-rift subsidence, association with low-angle normal faults; and are set within hot, thin crust similar to the Basin and Range province, but surrounded by active plate boundaries. The extensional faults systems play a major role in petroleum accumulation during syn-rift and post-rift phases in this area. This paper utilises well data and 3D seismic data from the Songkhla and Western basins of the western GoT. Structural balancing and restoration techniques are used to investigate the rate of extension and the effect on tectonostratigraphy. The basins are younger to the north, the Western basin was opened in Upper Oligocene to Lower Miocene. Stretching factors of the Western basin is approximately 1.1-1.2. Songkhla basin is the oldest basin that initial rift started in Eocene. The basin is dominated by major structures; western border fault, compressional structures related reactivated inversion fault, and inter-basinal faults. There are two main phases of tectonic activity; 1) Rifting phase which can be divided into three sub-extensional phase; Eocene, Oligocene, Lower Miocene. 2) Post

  17. An enhanced structure tensor method for sea ice ridge detection from GF-3 SAR imagery

    NASA Astrophysics Data System (ADS)

    Zhu, T.; Li, F.; Zhang, Y.; Zhang, S.; Spreen, G.; Dierking, W.; Heygster, G.

    2017-12-01

    In SAR imagery, ridges or leads are shown as the curvilinear features. The proposed ridge detection method is facilitated by their curvilinear shapes. The bright curvilinear features are recognized as the ridges while the dark curvilinear features are classified as the leads. In dual-polarization HH or HV channel of C-band SAR imagery, the bright curvilinear feature may be false alarm because the frost flowers of young leads may show as bright pixels associated with changes in the surface salinity under calm surface conditions. Wind roughened leads also trigger the backscatter increasing that can be misclassified as ridges [1]. Thus the width limitation is considered in this proposed structure tensor method [2], since only shape feature based method is not enough for detecting ridges. The ridge detection algorithm is based on the hypothesis that the bright pixels are ridges with curvilinear shapes and the ridge width is less 30 meters. Benefited from GF-3 with high spatial resolution of 3 meters, we provide an enhanced structure tensor method for detecting the significant ridge. The preprocessing procedures including the calibration and incidence angle normalization are also investigated. The bright pixels will have strong response to the bandpass filtering. The ridge training samples are delineated from the SAR imagery in the Log-Gabor filters to construct structure tensor. From the tensor, the dominant orientation of the pixel representing the ridge is determined by the dominant eigenvector. For the post-processing of structure tensor, the elongated kernel is desired to enhance the ridge curvilinear shape. Since ridge presents along a certain direction, the ratio of the dominant eigenvector will be used to measure the intensity of local anisotropy. The convolution filter has been utilized in the constructed structure tensor is used to model spatial contextual information. Ridge detection results from GF-3 show the proposed method performs better compared to the

  18. Seismic constraints on a large dyking event and initiation of a transform fault zone in Western Gulf of Aden

    NASA Astrophysics Data System (ADS)

    Ahmed, AbdulHakim; Doubre, Cecile; Leroy, Sylvie; Perrot, Julie; Audin, Laurence; Rolandone, Frederique; Keir, Derek; Al-Ganad, Ismael; Sholan, Jamal; Khanbari, Khaled; Mohamed, Kassim; Vergne, Jerome; Jacques, Eric; Nercessian, Alex

    2013-04-01

    In November 2010, a large number of events were recorded by the world seismic networks showing important activity occurring along the western part of the Aden Ridge. West of the Shulka El Sheik fracture zone, events in this large seismic swarm (magnitudes above 5) occurred in a complex area, where the change of both the ridge direction and the bathymetry suggest the propagation of the ridge into a continental lithosphere and the influence of the Afar plume. We combine several sets of data from permanent networks and temporary 3C broad stations installed after the beginning of the event along the southern and eastern coasts of Yemen and Djibouti respectively, we located more than 600 earthquakes with magnitudes ranging from 2.5 to 5.6 that occurred during the first months following the first event. The spatial distribution of the main seismicity reveals a very clear N115° -trending alignment, parallel to the mean direction of the en-echelon spreading segments that form the ridge at this longitude. Half of the events, which represent half of the total seismic energy released during the first months, are located in the central third section of the segment. Here several volcanic cones and recent lava flows observed from bathymetric and acoustic reflectivity data during the Tadjouraden cruise (Audin, 1999, Dauteuil et al., 2001) constitute the sea floor. In addition to this main activity, two small groups of events suggest the activiation of landslides into a large fan and the activity in a volcanic area 50 km due east from the main active zone. The time evolution of the seismicity shows several bursts of activity. Some of them are clearly related to sudden activities within the volcanic areas, when others exhibit horizontal migration of the events, with velocity around ˜ 1 km/h. The time-space evolution of the seismicity clearly reveals the intrusion of dykes associated with magma propagation from the crustal magmatic centres into the rift zone. Taking into account

  19. Hydrodynamic role of longitudinal dorsal ridges in a leatherback turtle swimming

    PubMed Central

    Bang, Kyeongtae; Kim, Jooha; Lee, Sang-Im; Choi, Haecheon

    2016-01-01

    Leatherback sea turtles (Dermochelys coriacea) are known to have a superior diving ability and be highly adapted to pelagic swimming. They have five longitudinal ridges on their carapace. Although it was conjectured that these ridges might be an adaptation for flow control, no rigorous study has been performed to understand their hydrodynamic roles. Here we show that these ridges are slightly misaligned to the streamlines around the body to generate streamwise vortices, and suppress or delay flow separation on the carapace, resulting in enhanced hydrodynamic performances during different modes of swimming. Our results suggest that shapes of some morphological features of living creatures, like the longitudinal ridges of the leatherback turtles, need not be streamlined for excellent hydro- or aerodynamic performances, contrary to our common physical intuition. PMID:27694826

  20. Data Sharing Report Characterization of Isotope Row Facilities Oak Ridge National Laboratory Oak Ridge TN

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Weaver, Phyllis C.

    The U.S. Department of Energy (DOE) Oak Ridge Office of Environmental Management (EM-OR) requested that Oak Ridge Associated Universities (ORAU), working under the Oak Ridge Institute for Science and Education (ORISE) contract, provide technical and independent waste management planning support using funds provided by the American Recovery and Reinvestment Act (ARRA). Specifically, DOE EM-OR requested ORAU to plan and implement a survey approach, focused on characterizing the Isotope Row Facilities located at the Oak Ridge National Laboratory (ORNL) for future determination of an appropriate disposition pathway for building debris and systems, should the buildings be demolished. The characterization effort wasmore » designed to identify and quantify radiological and chemical contamination associated with building structures and process systems. The Isotope Row Facilities discussed in this report include Bldgs. 3030, 3031, 3032, 3033, 3033A, 3034, 3036, 3093, and 3118, and are located in the northeast quadrant of the main ORNL campus area, between Hillside and Central Avenues. Construction of the isotope production facilities was initiated in the late 1940s, with the exception of Bldgs. 3033A and 3118, which were enclosed in the early 1960s. The Isotope Row facilities were intended for the purpose of light industrial use for the processing, assemblage, and storage of radionuclides used for a variety of applications (ORNL 1952 and ORAU 2013). The Isotope Row Facilities provided laboratory and support services as part of the Isotopes Production and Distribution Program until 1989 when DOE mandated their shutdown (ORNL 1990). These facilities performed diverse research and developmental experiments in support of isotopes production. As a result of the many years of operations, various projects, and final cessation of operations, production was followed by inclusion into the surveillance and maintenance (S&M) project for eventual decontamination and decommissioning (D

  1. Mantle Sources Beneath the SW Indian Ridge - Remelting the African Superplume

    NASA Astrophysics Data System (ADS)

    Dick, H. J. B.; Zhou, H.

    2012-04-01

    The SW Indian Ridge runs some 7700 km from the Bouvet to the Rodgriguez Triple Junction, crossing over or near two postulated mantle plumes. The latter are associated with large oceanic rises where the ridge axis shoals dramatically in the vicinity of the mantle hotspot. The Marion Rise, extends 3100 km from the Andrew Bain FZ to near the Rodriguez TJ, with an along axis rise of 5600-m to it crest north of Marion Island. The rise has thin crust inferred on the basis of abundant exposures of mantle peridotites along its length. We suggest that this is the result of its sub-axial mantle source, which is a depleted residue originally emplaced by the African Superplume into the asthenosphere beneath southern Africa during the Karoo volcanic event ~185 Ma. Based on shallow mantle anisotropy, plate reconstructions, and hotspot traces, it now forms the mantle substrate for the SW Indian Ridge due to the breakup of Gondwanaland. The Marion Rise is associated with Marion Island, the present location of the Marion Hotspot, some 256 km south of the modern ridge. This plume is a vestigial remnant of the African Superplume now imbedded in and centered on asthenospheric mantle derived from the Karoo event. Based on the numerous large offset fracture zones, which would dam sub-axial asthenospheric flow along the ridge, the low postulated flux of the Marion plume, its off-axis position, and the thin crust along the ridge it is clear that the present day plume does not support the Marion Rise. Instead, this must be supported isostatically by the underlying mantle residue of the Karoo event. The Bouvet Rise is much shorter than the Marion Rise, extending ~664 km from the Conrad FZ on the American-Antarctic Ridge to the Shaka FZ on the SW Indian Ridge. It has ~3000-m of axial relief, peaking at Speiss Smt at Speiss Ridge: the last spreading segment of the SW Indian Ridge adjacent to the Bouvet TJ. Unlike the Marion plume, Bouvet is ridge-centered, and much of its rise is likely

  2. Geospatializing The Klang Gate Quartz Ridge in Malaysia: A Technological Perspective

    NASA Astrophysics Data System (ADS)

    Azahari Razak, Khamarrul; Mohamad, Zakaria; Zaki Ibrahim, Mohd; Azad Rosle, Qalam; Hattanajmie Abd Wahab, Mohd; Abu Bakar, Rabieahtul; Mohd Akib, Wan Abdul Aziz Wan

    2015-04-01

    Establishment of inventories on geological heritage, or geoheritage resources is a step forward for a comprehensive geoheritage management leading to a better conservation at national and global levels. Compiling and updating inventory of geoheritage is a tedious process and even so in a tropical environment. Malaysia has a tremendous list of geodiversity and generating its national database is a multi-institutional effort and worthwhile investment. However, producing accurate and reliable characteristics of such landform and spectacular geological features remained elusive. The advanced and modern mapping techniques have revolutionized the mapping, monitoring and modelling of the earth surface processes and landforms. Yet the methods for quantification of geodiversity physical features are not fully utilized in Malaysia for a better understanding its processes and activity. This study provides a better insight into the use of advanced active remote sensing technology for characterizing the forested Quartz Ridge in Malaysia. We have developed the novel method and tested in the Klang Gates Quartz Ridge, Selangor. The granitic country rock made up by quartz mineral is known as the longest quartz ridge in Malaysia and characterized by rugged topography, steep slopes, densely vegetated terrain and also rich-biodiversity area. This study presents an integrated field methodological framework and processing scheme by taking into account the climatic, topographic, geologic, and anthropogenic challenges in an equatorial region. Advanced terrestrial laser scanning system was used to accurately capture, map and model the ridge carried out within a relatively stringent time period. The high frequency Global Navigation Satellite System and modern Total Station coupled with the optical satellite and radar imageries and also advanced spatial analysis were fully utilized in the field campaign and data assessment performed during the recent monsoon season. As a result, the mapping

  3. Morphology of sea ice pressure ridges in the northwestern Weddell Sea in winter

    NASA Astrophysics Data System (ADS)

    Tan, Bing; Li, Zhi-Jun; Lu, Peng; Haas, Christian; Nicolaus, Marcel

    2012-06-01

    To investigate the morphology and distribution of pressure ridges in the northwestern Weddell Sea, ice surface elevation profiles were measured by a helicopter-borne laser altimeter during Winter Weddell Outflow Study with the German R/V Polarstern in 2006. An optimal cutoff height of 0.62 m, derived from the best fits between the measured and theoretical ridge height and spacing distributions, was first used to separate pressure ridges from other sea ice surface undulations. It was found that the measured ridge height distribution was well modeled by a negative exponential function, and the ridge spacing distribution by a lognormal function. Next, based on the ridging intensity Ri (the ratio of mean ridge sail height to mean spacing), all profiles were clustered into three regimes by an improved k-means clustering algorithm: Ri ≤ 0.01, 0.01 < Ri ≤ 0.026, and Ri > 0.026 (denoted as C1, C2, and C3 respectively). Mean (and standard deviation) of sail height was 0.99 (±0.07) m in Regime C1, 1.12 (±0.06) m in C2, and 1.17 (±0.04) m in C3, respectively, while the mean spacings (and standard deviations) were 232 (±240) m, 54 (±20) m, and 31 (±5.6) m. These three ice regimes coincided closely with distinct sea ice regions identified in a satellite radar image, where C1 corresponded to the broken ice in the marginal ice zone and level ice formed in the Larsen Polynya, C2 corresponded to the deformed first- and second-year ice formed by dynamic action in the center of the study region, and C3 corresponded to heavily deformed ice in the outflowing branch of the Weddell Gyre. The results of our analysis showed that the relationship between the mean ridge height and frequency was well modeled by a logarithmic function with a correlation coefficient of 0.8, although such correlation was weaker when considering each regime individually. The measured ridge height and frequency were both greater than those reported by others for the Ross Sea. Compared with reported

  4. The rise and fall of axial highs during ridge jumps

    NASA Astrophysics Data System (ADS)

    Shah, Anjana K.; Buck, W. Roger

    2006-08-01

    We simulate jumps of ocean spreading centers with axial high topography using elastoplastic thin plate flexure models. Processes considered include ridge abandonment, the breaking of a stressed plate on the ridge flank, and renewed spreading at the site of this break. We compare model results to topography at the East Pacific Rise between 15°25'N and 16°N, where there is strong evidence of a recent ridge jump. At an apparently abandoned ridge, gravity data do not suggest buoyant support of topography. Model deflections during cooling and melt solidification stages of ridge abandonment are of small vertical amplitude because of plate strengthening, resulting in the preservation of a "frozen" fossil high. The present-day high is bounded by slopes with up to a 40% grade, a scenario very difficult to achieve flexurally given generally accepted constraints on lithospheric strength. We model these slopes by assuming that the height at which magma is accreted increases rapidly after the ridge jumps. This increase is attributed to high overburden pressure on melt that resided in an initially deep magma chamber, followed by a rapid increase in temperature and melt supply to the region shortly after spreading began. The high is widest at the segment center, suggesting that magmatic activity began near the center of the segment, propagated south and then north. The mantle Bouguer anomaly exhibits a "bull's-eye" pattern centered at the widest part of the high, but the depth of the axis is nearly constant along the length of the segment. We reconcile these observations by assigning different cross-axis widths to a low-density zone within the crust.

  5. Planktic foraminifer census data from Northwind Ridge Core 5, Arctic Ocean

    USGS Publications Warehouse

    Foley, Kevin M.; Poore, Richard Z.

    1991-01-01

    The U.S. Geological Survey recovered 9 piston cores from the Northwind Ridge in the Canada Basin of the Arctic Ocean from a cruise of the USCGC Polar Star during 1988. Preliminary analysis of the cores suggests sediments deposited on Northwind Ridge preserve a detailed record of glacial and interglacial cycles for the last few hundred-thousand to one million years. This report includes quantitative data on foraminifers and selected sediment size-fraction data in samples from Northwind Ridge core PI-88AR P5.

  6. Seismotectonics of the Gagua Ridge area from OBS data

    NASA Astrophysics Data System (ADS)

    Chen, Y. F.; Lin, J. Y.; Lee, C. S.; Hsu, S. K.; Liang, C. W.

    2012-04-01

    Gagua Ridge, located on the east of Taiwan Island, is generally considered an inactive ridge. This ridge is a N-S trending tectonic feature and separates two oceanic basin of different ages, which are the Huatung Basin in the west and the West Philippine Basin in the east respectively. On 26 April 2010, a Mw=6.9 event, characterized by a strike-slip mechanism, occurred in the east of the Gagua Ridge. The distribution of background earthquakes shows low seismic activity in the vicinity of the mainshock. A network of OBSs was deployed around the mainshock for 21 days. The network contains part of the West Philippine Basin and of the Gagua Ridge. In total, 1,711 earthquakes were determined. Most of the earthquakes occurred near the mainshock and few earthquakes scattered near the Gagua Ridge. Relocated hypocenters, which are relocated by hypoDD software, are clustered and aligned to the NW-SE direction. It indicates that the area is dominated by a sinistral strike-slip mechanism. In West Philippine Basin, two main geological structures, oriented NE-SW and NW-SE, were recognized from bathymetry map. The two features are associated with the first spreading event in West Philippine Basin and an old oceanic fracture zone. Since the trending of the cluster in our study is different from the strikes of the two features in the West Philippine Basin, the seismicity seems not to be linked to the reactivation of the former structures. Magnetic anomaly shows a NW-SE trending anomaly in the east of Taiwan Island, was suggested a present-day transform margin. The cluster is located on the SE end of boundary of the anomaly and the trending of the cluster is consistent with the orientation of the anomaly, which is parallel to the direction of Eurasia-Philippine relative motion. Therefore, we suggest that the presence of the sinistral strike-slip fault may reflect the different stress states in each side of the fault and form a stress transform boundary.

  7. 247. Axial Parkway alignment along ridge top. Note the open ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    247. Axial Parkway alignment along ridge top. Note the open vistas to either side of the roadway. These are maintained through vegetation management. The wood guide rail is a primary safety feature. View is to the northeast. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  8. Fingerprint Ridge Count: A Polygenic Trait Useful in Classroom Instruction.

    ERIC Educational Resources Information Center

    Mendenhall, Gordon; And Others

    1989-01-01

    Describes the use of the polygenic trait of total fingerprint ridge count in the classroom as a laboratory investigation. Presents information on background of topic, fingerprint patterns which are classified into three major groups, ridge count, the inheritance model, and activities. Includes an example data sheet format for fingerprints. (RT)

  9. Geochemistry of pyrite from diamictites of the Hamersley Basin, Western Australia with implications for the GOE and Paleoproterozoic ice ages.

    NASA Astrophysics Data System (ADS)

    Swanner, Elizabeth; Cates, Nicole; Pecoits, Ernesto; Bekker, Andrey; Konhauser, Kurt O.; Mojzsis, Stephen J.

    2013-04-01

    Sediments of the ca. 2400 Ma Turee Creek Group of Western Australia span the oxygenation of Earth's surface resulting from the 'Great Oxidation Event' (GOE). Diamictite within the Boolgeeda Iron Formation from the Boundary Ridge section at Duck Creek Syncline have been correlated to the glaciogenic Meteorite Bore Member of the Turee Creek Group at Hardey Syncline (Martin, 1999). The Meteorite Bore Member is thought to be correlative and time-equivalent with the Paleoproterozoic glacial diamictites of North America. If diamictite units at Boundary Ridge represent worldwide Paleoproterozoic glaciations, they should record the disappearance of mass independently fractionated (MIF) sulfur. Triple S-isotope compositions for pyrites from the Boundary Ridge sections measured by in situ multi-collector ion microprobe yielded both mass-dependent and mass-independently fractionated (MIF) S isotope values (Δ33S values from -0.65 to 6.27). Trace element heterogeneities were found by measurements at multiple spatial scales within rounded pyrites in the Boundary Ridge section, signifying multiple generations of pyrite from sulfur processed in an anoxic atmosphere. S-isotope data from pyrite in the Boundary Ridge diamictites analyzed in this study and previous work (Williford et al., 2011) define multiple δ34S vs. δ33S arrays, linked to a source of detrital pyrite from the overlying Hamersley and Fortescue groups. Authigenic pyrite in an overlying shale unit from Boundary Ridge plot along the terrestrial fractionation line but retain positive MIF-S and detrital pyrite, results that are incompatible with a correlation to North American Paleoproterozoic glacially-influenced successions where the MIF-S signal permanently disappears. The diamictites at the Duck Creek Syncline are older than the Meteorite Bore Member because of their stratigraphic position within the Boolgeeda Iron Formation underlying the Turee Creek Group, which is separated from the Meteorite Bore Member by

  10. Potential for Dietary ω-3 Fatty Acids to Prevent Nonalcoholic Fatty Liver Disease and Reduce the Risk of Primary Liver Cancer123

    PubMed Central

    Jump, Donald B; Depner, Christopher M; Tripathy, Sasmita; Lytle, Kelli A

    2015-01-01

    Nonalcoholic fatty liver disease (NAFLD) has increased in parallel with central obesity, and its prevalence is anticipated to increase as the obesity epidemic remains unabated. NAFLD is now the most common cause of chronic liver disease in developed countries and is defined as excessive lipid accumulation in the liver, that is, hepatosteatosis. NAFLD ranges in severity from benign fatty liver to nonalcoholic steatohepatitis (NASH), and NASH is characterized by hepatic injury, inflammation, oxidative stress, and fibrosis. NASH can progress to cirrhosis, and cirrhosis is a risk factor for primary hepatocellular carcinoma (HCC). The prevention of NASH will lower the risk of cirrhosis and NASH-associated HCC. Our studies have focused on NASH prevention. We developed a model of NASH by using mice with the LDL cholesterol receptor gene ablated fed the Western diet (WD). The WD induces a NASH phenotype in these mice that is similar to that seen in humans and includes robust induction of hepatic steatosis, inflammation, oxidative stress, and fibrosis. With the use of transcriptomic, lipidomic, and metabolomic approaches, we examined the capacity of 2 dietary ω-3 (n–3) polyunsaturated fatty acids, eicosapentaenoic acid (20:5ω-3; EPA) and docosahexaenoic acid (22:6ω-3; DHA), to prevent WD-induced NASH. Dietary DHA was superior to EPA at attenuating WD-induced changes in plasma lipids and hepatic injury and at reversing WD effects on hepatic metabolism, oxidative stress, and fibrosis. The outcome of these studies suggests that DHA may be useful in preventing NASH and reducing the risk of HCC. PMID:26567194

  11. Summary of the hydrogeology of the Valley and Ridge, Blue Ridge, and Piedmont Physiographic Provinces in the eastern United States

    USGS Publications Warehouse

    Swain, Lindsay A.; Mesko, Thomas O.; Hollyday, Este F.

    2004-01-01

    The Appalachian Valley and Piedmont Regional Aquifer-System Analysis study (1988-1993) analyzed rock types in the 142,000-square-mile study area, identified hydrogeologic terranes, determined transmissivity distributions, determined the contribution of ground water to streamflow, modeled ground-water flow, described water quality, and identified areas suitable for the potential development of municipal and industrial ground-water supplies. Ground-water use in the Valley and Ridge, the Blue Ridge, and the Piedmont Physiographic Provinces exceeds 1.7 billion gallons per day.Thirty-three rock types in the study area were analyzed, and the rock types with similar water-yielding characteristics were combined and mapped as 10 hydrogeologic terranes. Based on well records, the interquartile ranges of estimated transmissivities are between 180 to 17,000 feet squared per day (ft2/d) for five hydrologic terranes in the Valley and Ridge; between 9 to 350 ft2/d for two terranes in the Blue Ridge; and between 9 to 1,400 ft2/d for three terranes in the Piedmont Physiographic Province. Based on streamflow records, the interquartile ranges of estimated transmissivities for all three physiographic provinces are between 290 and 2,900 ft2/d. The mean ground-water contribution to streams from 157 drainage basins ranges from 32 to 94 percent of mean streamflow with a median of 67 percent. In three small areas in two of the physiographic provinces, more than 54 percent of ground-water flow was modeled as shallow and local. Although ground-water chemical composition in the three physiographic provinces is distinctly different, the water generally is not highly mineralized, with a median dissolved-solids concentration of 164 milligrams per liter, and is mostly calcium, magnesium, and bicarbonate. Based on aquifer properties and current pumpage, areas favorable for the development of municipal and industrial ground-water supplies are underlain by alluvium of glacial origin near the

  12. Eskers in Ireland, analogs for sinuous ridges on Mars

    NASA Astrophysics Data System (ADS)

    Pellicer, Xavier; Bourke, Mary

    2014-05-01

    Sinuous ridges on the surface of Mars are often inferred as putative esker ridges. Eskers cover several hundred kilometers of the Irish landscape and are one of the dominant landforms in the Irish Midlands. Well exposed stratigraphic sections and the body of existing knowledge due to extensive research carried out on these landforms make the Irish eskers an excellent analog for sinuous ridges on Mars. The Irish Eskers are sinuous ridges 0.1 - 80 km long, 20 - 500 m wide and 4 - 50 m high laid down by glacial meltwater in tunnels and crevasses in stationary or retreating ice sheets. They are commonly composed of sands and gravels with rounded boulders and cobbles. The gravels are usually bedded and the beds often slump towards the flank of the esker, indicating collapse as the confining ice walls melt. Four types of eskers have been identified in Ireland: (i) Continuous subglacial tunnel fill represents deposition within tunnels underneath or within an ice body originally used as water escape conduits; (ii) Continuous fluvial ice-channel fill deposit in channels cut into the ice on top of the glacier or down to the substrate subsequently infilled by sediments; (iii) Long beads - subglacial tunnel fill are segmented ridges, with a length-width ratio of 5:1 to 10:1, representing sequential deposition near or at the ice margin as the ice sheet retreats; (iv) Short beads are glaciolacustrine deposits interpreted as sequential deposition of ice-contact subaqueous outwash fans. Irish eskers have significant morphological similarities with those identified on Mars providing an opportunity for an insightful morphological and morphometric analysis to determine potential formative environments on Mars. Putative Martian eskers are 2-300 km long, 50-3000 m wide and 10-150 m high. The Irish eskers are similar in scale and present dimensions within these ranges. Eskers in Ireland are composed of sand and gravel with cobbles and boulders. Mars esker-like ridges observed in high

  13. Serpula and Spiraserpula (Polychaeta, Serpulidae) from the Tropical Western Atlantic and Gulf of Guinea

    PubMed Central

    Bastida-Zavala, Rolando

    2012-01-01

    Abstract Six species of Serpula and Spiraserpula were identified, mainly, from the material of the expeditions of the Rosenstiel School of Marine and Atmospheric Science, University of Miami, including two new species of Serpula. Serpula madrigalae sp. n. from the Turks and Caicos has a tube with five longitudinal ridges, four rows of alveoli and a medium-sized shallow symmetrical opercular funnel with 17 radii, and an inner surface with opercular tubercles. Serpula vossae sp. n. from the Western Caribbean and Bahamas has a tube with 6–8 longitudinal ridges, and a large, deep symmetrical opercular funnel, with 21–33 radii, and a smooth inner surface. Serpula cf. vermicularis, recorded from the Gulf of Guinea (tropical eastern Atlantic), is distinguished from the nominal species in possessing fewer opercular radii (33–39) and the lack of a proximal rasp in the bayonet chaetae; tubes are missing. The distribution range is extended for the three known Spiraserpula species found in the collections, Spiraserpula caribensis, Spiraserpula karpatensis and Spiraserpula ypsilon. PMID:22707904

  14. Crustal structure of the Agulhas Ridge (South Atlantic Ocean): Formation above a hotspot?

    NASA Astrophysics Data System (ADS)

    Jokat, Wilfried; Hagen, Claudia

    2017-10-01

    The southern South Atlantic Ocean contains several features believed to document the traces of hotspot volcanism during the early formation of the ocean basin, namely the Agulhas Ridge and the Cape Rise seamounts located in the southeast Atlantic between 36°S and 50°S. The Agulhas Ridge parallels the Agulhas-Falkland Fracture Zone, one of the major transform zones of the world. The morphology of the ridge changes dramatically from two parallel segments in the southwest, to the broad plateau-like Agulhas Ridge in the northeast. Because the crustal fabric of the ridge is unknown relating its evolution to hotspots in the southeast Atlantic is an open question. During the RV Polarstern cruise ANT-XXIII-5 seismic reflection and refraction data were collected along a 370 km long profile with 8 Ocean Bottom Stations to investigate its crustal fabric. The profile extends in NNE direction from the Agulhas Basin, 60 km south of the Agulhas Ridge, and continues into the Cape Basin crossing the southernmost of the Cape Rise seamounts. In the Cape Basin we found a crustal thickness of 5.5-7.5 km, and a velocity distribution typical for oceanic crust. The Cape Rise seamounts, however, show a higher velocity in comparison to the surrounding oceanic crust and the Agulhas Ridge. Underplated material is evident below the southernmost of the Cape Rise seamounts. It also has a 5-8% higher density compared to the Agulhas Plateau. The seismic velocities of the Agulhas Ridge are lower, the crustal thickness is approximately 14 km, and age dating of dredge samples from its top provides clear evidence of rejuvenated volcanism at around 26 Ma. Seismic data indicate that although the Cape Rise seamounts formed above a mantle thermal anomaly it had a limited areal extent, whereas the hotspot material that formed the Agulhas Ridge likely erupted along a fracture zone.

  15. Chemical and Mineralogical Characterization of a Hematite-bearing Ridge on Mauna Kea, Hawaii: A Potential Mineralogical Process Analog for the Mount Sharp Hematite Ridge

    NASA Technical Reports Server (NTRS)

    Graff, T. G.; Morris, R. V.; Ming, D. W.; Hamilton, J. C.; Adams, M.; Fraeman, A. A.; Arvidson, R. E.; Catalano, J. G.; Mertzman, S. A.

    2014-01-01

    The Mars Science Laboratory (MSL) rover Curiosity landed in Gale Crater in August 2012 and is currently roving towards the layered central mound known as Mount Sharp [1]. Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) hyperspectral data indicate Mount Sharp contains an 5 km stratigraphic sequence including Fe-Mg smectites, hematite, and hydrated sulfates in the lower layers separated by an unconformity from the overlying anhydrous strata [1,2,3]. Hematite was initially detected in CRISM data to occur in the lower sulfate layers on the north side of the mound [2]. [3] further mapped a distinct hematite detection occurring as part of a 200 m wide ridge that extends 6.5 km NE-SW, approximately parallel with the base of Mount Sharp. It is likely a target for in-situ analyses by Curiosity. We document here the occurrence of a stratum of hematite-bearing breccia that is exposed on the Puu Poliahu cinder cone near the summit of Mauna Kea volcano (Hawaii) (Fig.1). The stratum is more resistant to weathering than surrounding material, giving it the appearance of a ridge. The Mauna Kea hematite ridge is thus arguably a potential terrestrial mineralogical and process analog for the Gale Crater hematite ridge. We are acquiring a variety of chemical and mineralogical data on the Mauna Kea samples, with a focus on the chemical and mineralogical information already available or planned for the Gale hematite ridge.

  16. Topographic and sedimentary features in the Yap subduction zone and their implications for the Caroline Ridge subduction

    NASA Astrophysics Data System (ADS)

    Dong, Dongdong; Zhang, Zhengyi; Bai, Yongliang; Fan, Jianke; Zhang, Guangxu

    2018-01-01

    The Yap subduction zone in the western Pacific presents some unique features compared to normal intra-oceanic subduction zones such as the subduction of an oceanic plateau. However, due to the relative paucity of geophysical data, the detailed structure remains unknown in this area. In this study, we present the latest high-quality swath bathymetry and multi-channel seismic data acquired synchronously in 2015 across the Yap subduction zone. The topographic and sedimentary features are intensively investigated and a modified evolutionary model of the Yap subduction zone is proposed. The two-stage evolution of the Parece Vela Basin (PVB) produced fabrics that are N-S trending and NW-SE trending. Our seismic data clearly reveal landslide deposits at the upper slope break of the forearc, to the north of the Yap Island, which was identified as the fault notch denoting a lithological boundary in previous work. The swath bathymetry and seismic profile reveal detailed horst and graben structures, including a crescent-shaped fault zone near the contact between the Yap Trench and the Caroline Ridge. A simple geometric model is proposed to explain the structure formation, indicating that the higher topography of the Caroline Ridge resulted in enhanced bending-related extension. A seismic angular unconformity (named R1) is identified in the Sorol Trough, marking the onset of rifting in the trough. Based on the sequence thickness and deposition rate by Deep Sea Drilling Project (DSDP), it is deduced that the Sorol Trough formed at 10 Ma or even earlier. A modified model for the Yap subduction zone evolution is proposed, incorporating three major tectonic events: the proto-Yap Arc rupture in the Oligocene, the collision of the Caroline Ridge and the Yap Trench in the late Oligocene or middle Miocene, and the onset of the Sorol Trough rifting in the late Miocene.

  17. Lower Tertiary laterite on the Iceland-Faeroe Ridge and the Thulean land bridge

    USGS Publications Warehouse

    Nilsen, T.H.

    1978-01-01

    CORES of a lower Tertiary lateritic palaeosol resting on basalt were recovered1 from Deep Sea Drilling Project Site 336 (Leg 38) on the north-east flank of the Iceland-Faeroe Ridge (Fig. 1), a major aseismic oceanic ridge that, together with Iceland, forms the Icelandic transverse ridge 2. The transverse ridge extends from the West European continental margin to the East Greenland continental margin, forming the geographic boundary and a partial barrier to flow of water between the Norwegian-Greenland Sea to the north and the northern North Atlantic Ocean to the south. The palaeosol indicates that at least part of the Iceland-Faeroe Ridge was above sea level during early Tertiary time3. Palaeogeographic and palaeooceanographic reconstructions suggest that it formed the main part of the Thulean land bridge that connected South-east Greenland and the Faeroe islands during the early Tertiary4. This report summarises the subsidence history of the Iceland-Faeroe Ridge relative to early Tertiary seafloor spreading, basaltic volcanism, and the development of the proposed Thulean land bridge. ?? 1978 Nature Publishing Group.

  18. Superposed ridges of the Hesperia Planum area on Mars

    NASA Technical Reports Server (NTRS)

    Raitala, Jouko

    1988-01-01

    Mare ridges of the Hesperia Planum area form linear, reticular and circular structures. The main factors effective in mare ridge formation have been: (1) a large areal, or maybe even global, shortening and compression, (2) major crustal tectonics, and (3) the moderation of tectonic movements by the megaregolith discontinuity layer(s) between surface lavas and the bedrock leaving the compressional thrust to dominate over other fault movements in surface tectonics.

  19. Ridge Regression for Interactive Models.

    ERIC Educational Resources Information Center

    Tate, Richard L.

    1988-01-01

    An exploratory study of the value of ridge regression for interactive models is reported. Assuming that the linear terms in a simple interactive model are centered to eliminate non-essential multicollinearity, a variety of common models, representing both ordinal and disordinal interactions, are shown to have "orientations" that are…

  20. Retrospective success and survival rates of dental implants placed after a ridge preservation procedure.

    PubMed

    Apostolopoulos, Peter; Darby, Ivan

    2017-04-01

    Ridge preservation is any procedure that takes place at the time of, or shortly after an extraction, to minimise resorption of the ridge and maximise bone formation within the socket. The aim of this project is to investigate the outcome of implant treatment following ridge preservation and compare it to an ungrafted implant control group. Following ethics approval, an electronic and manual search of patient records was conducted, and appropriate cases of implant placement following a ridge preservation procedure were identified. Forty-two patients with 51 implants at ridge-preserved sites were examined by one author (PA) with the following parameters assessed at each implant: pocket probing depth, bleeding on probing, presence/absence of plaque and radiographic bone loss. Clinical and radiographic findings were compared to an ungrafted implant control group and analysed by years in function. There was a 100% survival rate of implants in ridge-preserved sites. In the majority of cases, ridge preservation was performed in the anterior maxilla with a flap raised and the use of deproteinised bovine bone mineral and collagen membrane materials. The mean time in function was 31 (±24) months with a range of 2-102 months. Differences in the mean PPD, BOP, plaque index and radiographic bone loss were not statistically significant between implants at ridge-preserved or ungrafted sites. The overall success rate was around 58% for ungrafted implants and around 51% for implants in ridge-preserved sites. However, this difference was not statistically significant. In this retrospective study, implant placement at ridge-preserved sites was a predictable procedure that led to very high survival rates and similar success rates to implant placement at ungrafted sites. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Organochlorine pesticides, PCBs, trace elements and metals in western pond turtle eggs from Oregon

    USGS Publications Warehouse

    Henny, Charles J.; Beal, K.F.; Bury, R. Bruce; Goggans, R.

    2003-01-01

    With increased concern over the status of reptile populations globally, contaminant studies should be part of species evaluations. We analyzed eggs of western pond turtles from Fern Ridge Reservoir in western Oregon for 20 organochlorine (OC) pesticides or metabolites, 42 congener-specific polychlorinated biphenyls (PCBs), and 16 trace elements or metals. These eggs represent the first of this species analyzed. The OC pesticides and PCB residue concentrations in the western pond turtle eggs were generally low and similar to those found in eggs of snapping turtles from a remote site in Ontario, Canada. Western pond turtle eggs also contained mercury and chromium, which are metals of special concern. Although few reptilian eggs have been analyzed for metals, the 44.9 mug/g dry weight chromium in a western pond turtle egg in this study may be the highest reported in a reptilian egg. We found no significant difference in contaminant concentrations in eggs from nests in Oregon, where all turtle eggs failed to hatch compared to those where some eggs hatched. During this initial project, however, we were unable to assess fully the role of OCs, PCBs and other contaminants in the western pond turtle decline. Factors other than contaminants may be involved. In another study, snapping turtle eggs near the Great Lakes-St. Lawrence River basin were much more contaminated with evidence reported of effects on sex differentiation and reproductive endocrine function. Egg hatchability, the only reproductive parameter monitored, may not be the most sensitive endpoint. Other endpoints, including endocrine function, deformity rates, growth rates, and sex determination need study.

  2. Ridges in Mars' south polar region

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Complex of rectilinear intersecting ridges in the south polar region. This 20 x 14 km area image (frame 7908) is centered near 81.5 degrees south, 65 degrees west.

    Figure caption from Science Magazine

  3. Curvilinear ridges and related features in southwest Cydonia Mensae, Mars

    NASA Technical Reports Server (NTRS)

    Parker, Timothy J.; Schneeberger, Dale M.; Pieri, David C.; Saunders, R. Stephen

    1987-01-01

    Examined is a region on Mars in southwest Cydonia Mensae (32 deg lat., 17 deg long.) just northwest of the lowland/upland boundary escarpment. The dominant morphological features in this region are the clusters of large massifs and plateau outliers (PI), knobby material (K), and smooth lowland plains (Ps). Surrounding the clusters and linking many isolated knobs is a system of curvilinear ridges and arcuate terrain boundaries which tend to separate the massifs and knobs from the smooth plains. Curvilinear ridges are arcuate to nearly linear and smoother in plan than wrinkle ridges and show no apparent correlation with regional structural grain. They are typically 5 to 10 km long but can range from as little as 2 or 3 km to greater than 50 km long. The widths vary from about 100 m to as much as 2 km. Curvilinear ridges are most numerous within 100 km of the lowland/upland boundary escarpment and are associated with massifs and knobby terrain. Arcuate terrain boundaries appear between units of different apparent albedo or arcuate breaks in slope.

  4. Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells

    PubMed Central

    Magee, Nancy; Zou, An

    2016-01-01

    Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in the Western countries, affecting up to 25% of the general population and becoming a major health concern in both adults and children. NAFLD encompasses the entire spectrum of fatty liver disease in individuals without significant alcohol consumption, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and cirrhosis. NASH is a manifestation of the metabolic syndrome and hepatic disorders with the presence of steatosis, hepatocyte injury (ballooning), inflammation, and, in some patients, progressive fibrosis leading to cirrhosis. The pathogenesis of NASH is a complex process and implicates cell interactions between liver parenchymal and nonparenchymal cells as well as crosstalk between various immune cell populations in liver. Lipotoxicity appears to be the central driver of hepatic cellular injury via oxidative stress and endoplasmic reticulum (ER) stress. This review focuses on the contributions of hepatocytes and nonparenchymal cells to NASH, assessing their potential applications to the development of novel therapeutic agents. Currently, there are limited pharmacological treatments for NASH; therefore, an increased understanding of NASH pathogenesis is pertinent to improve disease interventions in the future. PMID:27822476

  5. Inferring the width of the upwelling region at mid-ocean ridges from the throttling effect of small-offset transforms: Implications for the dynamics of `normal' and plume-influenced mid- ocean ridges

    NASA Astrophysics Data System (ADS)

    Phipps Morgan, J.; Ranero, C. R.

    2006-12-01

    The fundamental question "How wide is the upwelling and melting region beneath mid-ocean ridges (MORs)?" remains a subject of ongoing debate after 4 decades of intensive study. The basic observational difficulty is that lateral melt migration has the potential to bring melt produced within a wide subaxial region to the ~2km- wide neovolcanic zone that has been observed to be the site of almost all oceanic crustal emplacement. Here we use an indirect approach to infer this width from the minimum length of the ridge-offsets that mark the limits of the `region of influence' of on-ridge plumes on the axial relief, axial morphology, and crustal thickness along the ridge — e.g. as seen along ridge segments influenced by the Galapagos and Iceland plumes, and at the terminations of fossil volcanic rifted margins and the paleo-Azores plume-ridge interaction. We adopt Vogt's [1972] hypothesis for along-ridge asthenospheric flow in a narrow vertical slot beneath the axis of plume- influenced `macro-segments'. We find that: (1) There is a threshold distance to the lateral offsets that bound plume-influenced macrosegments; all such `barrier offsets' are greater than ~30km, while smaller offsets do not appear to be a barrier to along-axis flow. (2) Recent seismic and E-M observations along the southern EPR are consistent with a narrow westward-dipping subaxial slot. (3) A similar pattern is seen in the often abrupt transitions between volcanic and non-volcanic rifted margins, which is discussed in a companion presentation by Ranero and Phipps Morgan (this meeting). (4) A ~30km width for the region of ridge upwelling and melting offers a simple conceptual explanation for the apparent ~30km threshold length for the existence of strike-slip transform faults and the occurrence of non-transform offsets at smaller ridge offset-distances. (5) It also offers a simple conceptual explanation for the largest scale of segmentation of axial relief seen at fast-spreading ridges; these 500

  6. Strategic trade between two regions with partial local consumer protection - General setup and nash equilibria

    NASA Astrophysics Data System (ADS)

    Iordanov, Iordan V.; Vassilev, Andrey A.

    2017-12-01

    We construct a model of the trade relations between two regions for the case when the trading entities (consumers) compete for a scarce good and there is an element of strategic interdependence in the trading process. Additionally, local consumers enjoy partial protection in the form of guaranteed access to a part of the locally-supplied quantity of the good. The model is formulated for the general asymmetric case, where the two regions differ in terms of parameters such as income, size of the local market supply, degree of protection and transportation costs. For this general model we establish the existence of Nash equilibria and obtain their form as a function of the model parameters, producing a typology of the equilibria. This is a required step in order to rigorously study various types of price dynamics for the model.

  7. Self-spreading of the wetting ridge during stick-slip on a viscoelastic surface

    DOE PAGES

    Park, S. J.; Bostwick, J. B.; De Andrade, V.; ...

    2017-10-23

    Dynamic wetting behaviors on soft solids are important to interpret complex biological processes from cell–substrate interactions. Despite intensive research studies over the past half-century, the underlying mechanisms of spreading behaviors are not clearly understood. The most interesting feature of wetting on soft matter is the formation of a “wetting ridge”, a surface deformation by a competition between elasticity and capillarity. Dynamics of the wetting ridge formed at the three-phase contact line underlies the dynamic wetting behaviors, but remains largely unexplored mostly due to limitations in indirect observation. Here, we directly visualize wetting ridge dynamics during continuous- and stick-slip motions onmore » a viscoelastic surface using X-ray microscopy. Strikingly, we discover that the ridge spreads spontaneously during stick and triggers contact line depinning (stick-to-slip transition) by changing the ridge geometry which weakens the contact line pinning. Finally, we clarify ‘viscoelastic-braking’, ‘stick-slipping’, and ‘stick-breaking’ spreading behaviors through the ridge dynamics. In stick-breaking, no ridge-spreading occurs and contact line pinning (hysteresis) is enhanced by cusp-bending while preserving a microscopic equilibrium at the ridge tip. We have furthered the understanding of spreading behaviors on soft solids and demonstrated the value of X-ray microscopy in elucidating various dynamic wetting behaviors on soft solids as well as puzzling biological issues.« less

  8. Site characterization summary report for dry weather surface water sampling upper East Fork Poplar Creek characterization area Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    This report describes activities associated with conducting dry weather surface water sampling of Upper East Fork Poplar Creek (UEFPC) at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. This activity is a portion of the work to be performed at UEFPC Operable Unit (OU) 1 [now known as the UEFPC Characterization Area (CA)], as described in the RCRA Facility Investigation Plan for Group 4 at the Oak- Ridge Y-12 Plant, Oak Ridge, Tennessee and in the Response to Comments and Recommendations on RCRA Facility Investigation Plan for Group 4 at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee, Volume 1,more » Operable Unit 1. Because these documents contained sensitive information, they were labeled as unclassified controlled nuclear information and as such are not readily available for public review. To address this issue the U.S. Department of Energy (DOE) published an unclassified, nonsensitive version of the initial plan, text and appendixes, of this Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) Plan in early 1994. These documents describe a program for collecting four rounds of wet weather and dry weather surface water samples and one round of sediment samples from UEFPC. They provide the strategy for the overall sample collection program including dry weather sampling, wet weather sampling, and sediment sampling. Figure 1.1 is a schematic flowchart of the overall sampling strategy and other associated activities. A Quality Assurance Project Plan (QAPJP) was prepared to specifically address four rounds of dry weather surface water sampling and one round of sediment sampling. For a variety of reasons, sediment sampling has not been conducted and has been deferred to the UEFPC CA Remedial Investigation (RI), as has wet weather sampling.« less

  9. The Oak Ridge Reservation Annual Site Environmental Report, 2007

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hughes, Joan; Thompson, Sharon; Page, David

    2008-09-30

    The Oak Ridge Reservation (ORR) consists of three major government-owned, contractor-operated facilities: the Y-12 National Security Complex, Oak Ridge National Laboratory, and East Tennessee Technology Park. The ORR was established in the early 1940s as part of the Manhattan Project, a secret undertaking that produced materials for the first atomic bombs. The reservation’s role has evolved over the years, and it continues to adapt to meet the changing defense, energy, and research needs of the United States. Both the work carried out for the war effort and subsequent research, development, and production activities have involved, and continue to involve, themore » use of radiological and hazardous materials. The Oak Ridge Reservation Annual Site Environmental Report and supporting data are available at Http://www.ornl.gov/sci/env_rpt or from the project director.« less

  10. Gravitational stresses in long symmetric ridges and valleys in anisotropic rock

    USGS Publications Warehouse

    Pan, E.; Amadei, B.; Savage, W.Z.

    1994-01-01

    The effect of topography and rock mass anisotropy on gravitational stresses in long isolated symmetric ridges and valleys is modeled using an analytical method proposed earlier by the first two authors. The rock mass deforms under a condition of plane strain. A parametric study is presented on the effect of (1) topography, (2) orientation of anisotropy and (3) degree of anisotropy on the magnitude and distribution of gravitational stresses in transversely isotropic rock masses with planes of anisotropy striking parallel to the ridge or valley axis. It is found that compressive stresses develop near ridge crests and that tensile stresses develop in valley bottoms and valley walls. The magnitude of the gravitational stresses is of the order of the characteristics stress ??{variant}g??b?? where ??{variant} is the rock density, g is the gravitational acceleration and ??b?? is the height of the ridge or depth of the valley. ?? 1994.

  11. Diffuse Volcanism at the Young End of the Walvis Ridge - Tristan - Gough Seamount Province: Geochemical Sampling and Constraints on Plume Dynamics

    NASA Astrophysics Data System (ADS)

    Class, C.; Koppers, A. A. P.; Sager, W. W.; Schnur, S.

    2014-12-01

    The Walvis Ridge-Tristan/Gough seamount province in the South Atlantic represents 130 Myr of continuous intra-plate volcanism that can be connected to the once conjunct Parana-Etendeka flood basalt province. With this it represents one of the few primary hotspots consistent with the thermal plume model. However, around 60 Ma, the morphological expression of the Walvis Ridge changed drastically from a robust 200 km wide aseismic ridge into a 400 km wide region of diffuse and diminished volcanism. As a result, this part of the plume trail has been described by two subtracks, one ending at Tristan da Cunha and another at Gough Island more than 400 km to the SSE. Where the Walvis Ridge forks into these two tracks there is a center prong. There is also the 39.5°S lineament of seamounts between, but oblique to, the two subtracks, which is parallel to the local fracture zone directions. All these features are at odds with the classical definition of a narrow hotspot track although Rohde et al. (2013) showed that the Tristan and Gough subtracks retain a distinct geochemical signature over 70 Myr and are consistent with a zoned, deep-seated plume. The first Sr-Nd-Hf-Pb isotopic and trace element analyses from the detailed dredge sampling cruise MV1203 show that samples from two prominent seamounts at the western end of the 39.5°S lineament have a Gough-type signature, which makes an upper mantle source for this lineament unlikely but rather indicates that the Gough-type source stretches some 200 km NNW from Gough. Tristan track seamount samples are comparable with published data, however, one new sample has a Gough-type composition suggesting leakage of this component into the Tristan-type plume zone. Seamounts on the middle prong of the Walvis Ridge fork have compositions intermediate to Gough and Tristan domains, suggesting mixing between sources or melts of the two domains. Thus, the Gough-component in the last 60 Myr of plume activity is volumetrically much more

  12. Late Palaeocene Mantle Plume Uplift on The Fugloy Ridge, NE Faroes

    NASA Astrophysics Data System (ADS)

    Hurst, N. W.; Kusznir, N. J.; Roberts, A. M.

    2004-12-01

    The Fugloy ridge is a large (~100 km wide) anticlinal structure situated to the NE of the Faroe Islands separating the Norwegian Ocean basin from the Faroe-Shetland trough. Flexural backstripping and post-breakup thermal subsidence modelling has been performed on a profile crossing the Fugloy Ridge to provide an estimate of mantle plume uplift at the end of the Palaeocene (~55 Ma). The modelling is carried out on a 370 km Q-marine multi-streamer swath reflection profile acquired by the M/V Geco Topaz during the summer of 2002 as part of the iSIMM (integrated Seismic Imaging and Modelling of Margins) project seismic acquisition programme. The profile provides good resolution of post-breakup sediment structure across the margin and also of deeper sub-basaltic structure along the profile. Flexural backstripping and reverse post-breakup thermal subsidence modelling is a 2D (or 3D) technique which is used to restore present day stratigraphic cross sections to earlier post-breakup times. The method removes units of stratigraphy from the top-downwards and calculates isostatic and sediment decompaction responses to this unloading. Thermal subsidence arises from the cooling of stretched continental lithosphere and the recently formed oceanic lithosphere, and may be predicted from the lithosphere beta stretching factor (McKenzie, 1978). Two approaches have been used to determine beta stretching estimates for the profile, the first approach uses beta stretching factors from crustal thinning estimates derived from a gravity anomaly inversion technique (Hurst et al., 2004). The second approach uses palaeo-bathymetric constraints to determine the beta stretching estimates for the profile. Results from the modelling show that the Fugloy Ridge present day stratigraphy flattens out progressively as the 2D cross section is restored to breakup (55 Ma) using beta stretching factor estimates derived from gravity anomaly inversion. The Fugloy Ridge has been proposed as a possible

  13. Asymmetric Crustal Accretion Across the Carlsberg Ridge (NW Indian Ocean) since the Paleocene

    NASA Astrophysics Data System (ADS)

    Chaubey, A.; Kamesh Raju, K.; Bhattacharya, G.; Dyment, J.; Royer, J.

    2006-12-01

    We present magnetic isochron map in conjunction with satellite derived free-air gravity anomaly image of the Carlsberg Ridge to understand crustal accretion across the ridge since its inception. Well-lineated and high- amplitude magnetic anomalies C1n through C2An and C20n through C28ny have been identified across the present- and paleo-Carlsberg Ridge respectively. Average full spreading rates of ~32 km/my for the past 4.18 Ma and ~46-260 km/my during C20n-C28ny respectively have been estimated based on model studies. Analysis of magnetic anomalies reveals that crustal accretion of SW flank of the Carlsberg Ridge was greater by ~5-20% as compared to its conjugate NE flank for the last 4 Myr. Whereas, accretion due to paleo- Carlsberg Ridge, in general, was ~20% consistently greater at NE flank (now known as the Arabian Basin) compared to its conjugate SW flank (now known as the Eastern Somali Basin) during 63 43 Ma. An instance of exception to this general scenario is observed during magnetic chron 24n.1y-23n.2o period (52.4-51.7 Ma) when accretion on the SW flank of the ridge was ~10% greater as compared to its conjugate part. These results indicate that crustal accretion across the Carlsberg Ridge was substantially asymmetric and represent both small- and large-scale crustal asymmetries for the past 63 Myr (C28n). Small-scale asymmetries vary between individual spreading corridors, whereas, large-scale asymmetries represented by consistent excess accretion on one of the two separating plates from the Late Paleocene to Middle Eocene. We propose that small-scale asymmetry resulted from discrete spreading-center jumps in the inner rift valley floor; whereas, spreading ridge propagation, which dominated pre-C20n spreading history of the Carlsberg Ridge, caused large-scale asymmetric crustal accretion. Asymmetric crustal accretion across mid-ocean ridge systems is common phenomena in the geologic past but processes that lead to asymmetry are not well resolved. The

  14. Discovery of abundant hydrothermal venting on the ultraslow-spreading Gakkel ridge in the Arctic Ocean.

    PubMed

    Edmonds, H N; Michael, P J; Baker, E T; Connelly, D P; Snow, J E; Langmuir, C H; Dick, H J B; Mühe, R; German, C R; Graham, D W

    2003-01-16

    Submarine hydrothermal venting along mid-ocean ridges is an important contributor to ridge thermal structure, and the global distribution of such vents has implications for heat and mass fluxes from the Earth's crust and mantle and for the biogeography of vent-endemic organisms. Previous studies have predicted that the incidence of hydrothermal venting would be extremely low on ultraslow-spreading ridges (ridges with full spreading rates <2 cm x yr(-1)-which make up 25 per cent of the global ridge length), and that such vent systems would be hosted in ultramafic in addition to volcanic rocks. Here we present evidence for active hydrothermal venting on the Gakkel ridge, which is the slowest spreading (0.6-1.3 cm x yr(-1)) and least explored mid-ocean ridge. On the basis of water column profiles of light scattering, temperature and manganese concentration along 1,100 km of the rift valley, we identify hydrothermal plumes dispersing from at least nine to twelve discrete vent sites. Our discovery of such abundant venting, and its apparent localization near volcanic centres, requires a reassessment of the geologic conditions that control hydrothermal circulation on ultraslow-spreading ridges.

  15. Sea ice ridging in the Ross Sea, Antarctica, as compared with sites in the Arctic

    NASA Astrophysics Data System (ADS)

    Weeks, W. F.; Ackley, S. F.; Govoni, J.

    1989-04-01

    At the end of the 1980 austral winter, surface roughness measurements were made by laser profilometer during a series of flights over the Ross Sea pack ice. The total track length was 2696 km, and 4365 ridges were counted. The frequency distribution of individual ridge heights was found to be well described by a negative exponential distribution. No clear-cut regional variation was noted in ridge heights. The distribution of ridge frequencies per kilometer showed a strong positive skew with a modal value of 1.88; the most frequent ridging occurred off the east coast of Victoria Land. Comparisons with similar data sets from the Arctic indicate that large ridges are significantly more likely in the Arctic Ocean than in the Ross Sea. Utilizing a reasonable model for the geometry of ridges, estimates are made of the average thickness of a hypothetical continuous layer composed only of the deformed ice from ridges. The noncoastal Ross Sea value of 0.09 m is less than half of the lowest comparable value from the Arctic (0.20 m, central Beaufort Sea) where values in excess of 1.0 m have been observed in the shear zones north of Greenland.

  16. Base-flow characteristics of streams in the Valley and Ridge, the Blue Ridge, and the Piedmont physiographic provinces of Virginia

    USGS Publications Warehouse

    Nelms, David L.; Harlow, George E.; Hayes, Donald C.

    1997-01-01

    Growth within the Valley and Ridge, Blue Ridge, and Piedmont physiographic provinces of Virginia has focused concern about allocation of surface-water flow and increased demands on the ground-water resources. Potential surface-water yield was determined from statistical analysis of base-flow characteristics of streams. Base-flow characteristics also may provide a relative indication of the potential ground-water yield for areas that lack sufficient specific capacity or will-yield data; however, other factors need to be considered, such as geologic structure, lithology, precipitation, relief, and the degree of hydraulic interconnection between the regolith and bedrock.

  17. On the origin of saline soils at Blackspring Ridge, Alberta, Canada

    NASA Astrophysics Data System (ADS)

    Stein, Richard; Schwartz, Franklin W.

    1990-09-01

    Problems of soil salinity occur at Blackspring Ridge, Alberta, in four different settings. The most seriously affected area is at the base of the ridge where salinity appears as severe salt crusting on the surface, salt-tolerant vegetation, and areas of poor or no crop production. Blackspring Ridge is a structural bedrock high that is underlain by Upper Cretaceous sediment of the Horseshoe Canyon Formation. Bedrock is overlain by fluvial, glacial, lacustrine, and aeolian sediment. Piezometric data indicate that groundwater is recharged on and along the upper flanks of Blackspring Ridge and discharges in southern parts of a lacustrine plain that surrounds the ridge. Hydraulic conductivity data, water-level fluctuations, stable isotopes, and hydrochemical data indicate that the fractured near-surface bedrock and overlying thin-drift sediment constitute a zone of active groundwater flow within which salts are generated and transported. Water discharging from this shallow system evaporates and forms saline areas at the base of the ridge. The most seriously affected areas on the lacustrine plain coincide with places where the water table is less than 1.5m from the ground surface. A high water table occurs locally because of the changing topology of geologic units, and lows in the topographic surface that focus groundwater and surface water flows. Some proportion of the shallow groundwater salinized by evaporation is also transported down the flow system where it mixes with unevaporated water. Surface water, from snowmelt and precipitation events, dissolves salt that was deposited at the surface by evaporating groundwater and redistributes the salt to areas of lower elevation.

  18. Wrinkle ridges on Venusian plains: Indicators of shallow crustal stress orientations at local and regional scales

    NASA Technical Reports Server (NTRS)

    Mcgill, George E.

    1992-01-01

    The plains regions of Venus exhibit a complex array of structural features, including deformation belts of various types, wrinkle ridges, grabens, and enigmatic radar-bright linears. Probably the most pervasive of these structures are the wrinkle ridges, which appear to be morphologically identical to their counterparts on the Moon and Mars. Almost all workers agree that wrinkle ridges result from horizontal compressive stresses in the crust; they either are explained as flexural fold structures, or alternatively as scarps or folds related to reverse faults. Wrinkle ridges generally are narrow, have small amplitudes, and commonly are closely spaced as well, characteristics that imply a shallow crustal origin. If wrinkle ridges are due to horizontally directed compressive stresses in the shallow crust, as generally has been inferred, then the trends of these features provide a means to map both local and regional orientations of principal stresses in the uppermost part of the venusian crust: maximum compressive stress is normal to the ridges, minimum compressive stress is normal to the topographic surface, and thus the wrinkle ridge trends trace the orientation of the intermediate principal stress. Because there are few plains areas on Venus totally devoid of wrinkle ridges, it should be possible to establish a number of interesting relationships on a near-global scale by mapping the trends of wrinkle ridges wherever they occur. The present study is addressing three questions: (1) Do the trends of wrinkle ridges define domains that are large relative to the sizes of individual plains regions? If so, can these domains be related to large-scale topographic or geologic features? (2) Are regional trends of wrinkle ridges affected by local features such as coronae? If so, is it possible to determine the relative ages of the far-field and local stresses from detailed study of trend inheritance or superposition relationships? (3) What is the relationship between wrinkle

  19. Issues relating to spent nuclear fuel storage on the Oak Ridge Reservation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klein, J.A.; Turner, D.W.

    1994-12-31

    Currently, about 2,800 metric tons of spent nuclear fuel (SNF) is stored in the US, 1,000 kg of SNF (or about 0.03% of the nation`s total) are stored at the US Department of Energy (DOE) complex in Oak Ridge, Tennessee. However small the total quantity of material stored at Oak Ridge, some of the material is quite singular in character and, thus, poses unique management concerns. The various types of SNF stored at Oak Ridge will be discussed including: (1) High-Flux Isotope Reactor (HFIR) and future Advanced Neutron Source (ANS) fuels; (2) Material Testing Reactor (MTR) fuels, including Bulk Shieldingmore » Reactor (BSR) and Oak Ridge Research Reactor (ORR) fuels; (3) Molten Salt Reactor Experiment (MSRE) fuel; (4) Homogeneous Reactor Experiment (HRE) fuel; (5) Miscellaneous SNF stored in Oak Ridge National Laboratory`s (ORNL`s) Solid Waste Storage Areas (SWSAs); (6) SNF stored in the Y-12 Plant 9720-5 Warehouse including Health. Physics Reactor (HPRR), Space Nuclear Auxiliary Power (SNAP-) 10A, and DOE Demonstration Reactor fuels.« less

  20. Magma plumbing system and seismicity of an active mid-ocean ridge volcano.

    PubMed

    Schmid, Florian; Schlindwein, Vera; Koulakov, Ivan; Plötz, Aline; Scholz, John-Robert

    2017-02-20

    At mid-ocean ridges volcanism generally decreases with spreading rate but surprisingly massive volcanic centres occur at the slowest spreading ridges. These volcanoes can host unexpectedly strong earthquakes and vigorous, explosive submarine eruptions. Our understanding of the geodynamic processes forming these volcanic centres is still incomplete due to a lack of geophysical data and the difficulty to capture their rare phases of magmatic activity. We present a local earthquake tomographic image of the magma plumbing system beneath the Segment 8 volcano at the ultraslow-spreading Southwest Indian Ridge. The tomography shows a confined domain of partial melt under the volcano. We infer that from there melt is horizontally transported to a neighbouring ridge segment at 35 km distance where microearthquake swarms and intrusion tremor occur that suggest ongoing magmatic activity. Teleseismic earthquakes around the Segment 8 volcano, prior to our study, indicate that the current magmatic spreading episode may already have lasted over a decade and hence its temporal extent greatly exceeds the frequent short-lived spreading episodes at faster opening mid-ocean ridges.