Science.gov

Sample records for national radiobiology archives

  1. National Radiobiology Archives distributed access programmer's guide

    SciTech Connect

    Prather, J. C.; Smith, S. K.; Watson, C. R.

    1991-12-01

    The National Radiobiology Archives is a comprehensive effort to gather, organize, and catalog original data, representative specimens, and supporting materials related to significant radiobiology studies. This provides researchers with information for analyses which compare or combine results of these and other studies and with materials for analysis by advanced molecular biology techniques. This Programmer's Guide document describes the database access software, NRADEMO, and the subset loading script NRADEMO/MAINT/MAINTAIN, which comprise the National Laboratory Archives Distributed Access Package. The guide is intended for use by an experienced database management specialist. It contains information about the physical and logical organization of the software and data files. It also contains printouts of all the scripts and associated batch processing files. It is part of a suite of documents published by the National Radiobiology Archives.

  2. National Radiobiology Archives Distributed Access user's manual

    SciTech Connect

    Watson, C.; Smith, S. ); Prather, J. )

    1991-11-01

    This User's Manual describes installation and use of the National Radiobiology Archives (NRA) Distributed Access package. The package consists of a distributed subset of information representative of the NRA databases and database access software which provide an introduction to the scope and style of the NRA Information Systems.

  3. Operation and Maintenance of the National Radiobiology Archives

    SciTech Connect

    Dr. Anthony C. James; Stacey L. McCord

    2012-03-07

    The National Radiobiology Archives (NRA) are an archival program, started in 1989, to collect, organize and maintain data, laboratory notebooks, and animal tissue specimens from government (Department of Energy and its predecessor agencies) sponsored radiobiology life-span animal studies. These unique records, histopathology slides and paraffin embedded tissue blocks are maintained in a central facility and are available for further research study. The materials include electronic and paper records for each of more than 6,000 life-span-observations on dogs as well as details of major studies involving nearly 30,000 mice. Although these studies were performed over many years and at different laboratories with differing data management systems, the NRA has translated them into a standardized set of relational database tables. These can be distributed to interested individuals on written request. Specific Aims are: (1) To Maintain the Archive of Written Records from the Animal Experiments - The USTUR continued to maintain the NRA archives which consist of approximately 175 storage boxes containing laboratory notebooks, animal exposure records, animal pathologic records, and radiographs. These were stored in a 6,000 square foot leased facility in Richland, WA. Additionally, through a collaboration with Pacific Northwest National Laboratory's (PNNL) Low Dose Program, many of these records were scanned into digital files. These totaled 34 GB of data, which are saved in 2,407 separate PDF files that are organized by box number and animal identification number. (2) To Maintain the Archive of Animal Tissues at Washington State University - The USTUR continued to house the NRA dog tissue collection in the leased facility. The NRA tissue collection consisted of pathology slides and tissue blocks. Approximately 25% of the laboratory facility was dedicated to the storage of the NRA materials. (3) To Organize the Datasets of These Animals in the Context of Other Datasets so That

  4. Beagle Dog Tissue Archive (previously part of National Radiobiology Archives): from the Janus Tissue Archive at Northwestern University

    DOE Data Explorer

    Watson, Charles R.

    Following the advent of the atomic age, many nations have investigated the effects of radioactive exposure in animal models. Some of these investigations involved costly and unique experiments that produced tissue and data archives which are unlikely to be reproduced. In an effort to extract the value from these collections, programs have started in Japan, Europe, and America to preserve and make public the data and tissues from these studies for further investigation. The Beagle Dog Experiments, carried out at Argonne National Laboratory from 1952 to 1991 by Thomas Fritz, William Norris, and Tom Seed and supported by grants from the Atomic Energy Commission, investigated the effects of Cobalt-60 radiation on beagle dogs. Documentation from these studies is availible in pdf form. This web portal seeks to make accessible the animal tissues and study data from the Beagle Dog Experiments using data organized by Charles Watson. Use the search form to the left to look for dog data from particular experimental conditions. Click a dog number to return the full dog record. Use the dog record to find tissues of interest and make a sample tissue request. These tissue samples and the data were known until recently as the the U.S. National Radiobiology Archives (NRA) and were maintained as the United States Transuranium and Uranium Registries (USTUR) at Washington State University. Life-span studies using beagle dogs were done at the Argonne National Laboratory, University of California at Davis, Pacific Northwest National Laboratory, Inhalation Toxicology Research Institute, and the University of Utah. The results and many microscope slides from these life-span studies, totaling some 6000 dogs, are now available to researchers. A seminal work included in the Archive is The Atlas of Experimentally-Induced Neoplasia in the Beagle Dog (Watson et al, 1997).

  5. Nation Radiobiology Archives Distributed Access

    SciTech Connect

    Smith, S. K.; Prather, J. C.; Ligotke, E. K.; Watson, C. R.

    1992-06-01

    NRADA1.1 is a supplement to NRADA1.0. This version eliminates several bugs, and includes a few new features. The diskettes consist of a distributed subset of information representative of the extensive NRA databases and database access software maintained at the Pacific Northwest Laboratory which provide an introduction to the scope and style of the NRA Information Systems. Information in the NRA Summary, Inventory, and Bibliographic database is available upon request. Printed reports have been provided in the past. The completion of the NRADA1.1 is the realization of a long standing goal of the staff and advisory committee. Information may be easily distributed to the user in an electronic form which preserves the relationships between the various databases.

  6. Nation Radiobiology Archives Distributed Access

    Energy Science and Technology Software Center (ESTSC)

    1992-06-01

    NRADA1.1 is a supplement to NRADA1.0. This version eliminates several bugs, and includes a few new features. The diskettes consist of a distributed subset of information representative of the extensive NRA databases and database access software maintained at the Pacific Northwest Laboratory which provide an introduction to the scope and style of the NRA Information Systems. Information in the NRA Summary, Inventory, and Bibliographic database is available upon request. Printed reports have been provided inmore » the past. The completion of the NRADA1.1 is the realization of a long standing goal of the staff and advisory committee. Information may be easily distributed to the user in an electronic form which preserves the relationships between the various databases.« less

  7. Past and Future Work on Radiobiology Mega-Studies: A Case Study At Argonne National Laboratory

    SciTech Connect

    Haley, Benjamin; Wang, Qiong; Wanzer, Beau; Vogt, Stefan; Finney, Lydia; Yang, Ping Liu; Paunesku, Tatjana; Woloschak, Gayle

    2011-09-06

    Between 1952 and 1992, more than 200 large radiobiology studies were conducted in research institutes throughout Europe, North America, and Japan to determine the effects of external irradiation and internal emitters on the lifespan and tissue toxicity development in animals. At Argonne National Laboratory, 22 external beam studies were conducted on nearly 700 beagle dogs and 50,000 mice between 1969 and 1992. These studies helped to characterize the effects of neutron and gamma irradiation on lifespan, tumorigenesis, and mutagenesis across a range of doses and dosing patterns. The records and tissues collected at Argonne during that time period have been carefully preserved and redisseminated. Using these archived data, ongoing statistical work has been done and continues to characterize quality of radiation, dose, dose rate, tissue, and gender-specific differences in the radiation responses of exposed animals. The ongoing application of newly-developed molecular biology techniques to the archived tissues has revealed gene-specific mutation rates following exposure to ionizing irradiation. The original and ongoing work with this tissue archive is presented here as a case study of a more general trend in the radiobiology megastudies. These experiments helped form the modern understanding of radiation responses in animals and continue to inform development of new radiation models. Recent archival efforts have facilitated open access to the data and materials produced by these studies, and so a unique opportunity exists to expand this continued research.

  8. Past and Future Work on Radiobiology Mega Studies: A Case Study at Argonne National Laboratory

    PubMed Central

    Haley, Benjamin; Wang, Qiong; Wanzer, Beau; Vogt, Stefan; Finney, Lydia; Yang, Ping Liu; Paunesku, Tatjana; Woloschak, Gayle

    2013-01-01

    Between 1952 and 1992 more than 200 large radiobiology studies were conducted in research institutes throughout Europe, North America and Japan to determine the effects of external irradiation and internal emitters on the life span and tissue toxicity development in animals. At Argonne National Laboratory, 22 external beam studies were conducted on nearly 700 beagle dogs and 50,000 mice between 1969 and 1992. These studies helped to characterize the effects of neutron and gamma irradiation on lifespan, tumorigenesis, and mutagenesis across a range of doses and dosing patterns. The records and tissues collected at Argonne during that time period have been carefully preserved and redisseminated. Using these archived data ongoing statistical work has been done and continues to characterize quality of radiation, dose, dose rate, tissue, and gender specific differences in the radiation responses of exposed animals. The ongoing application of newly developed molecular biology techniques to the archived tissues has revealed gene specific mutation rates following exposure to ionizing irradiation. The original and ongoing work with this tissue archive is presented here as a case study of a more general trend in the radiobiology mega studies. These experiments helped form the modern understanding of radiation responses in animals, and continue to inform development of new radiation models. Recent archival efforts have facilitated open access to the data and materials produced by these studies and so a unique opportunity exists to expand this continued research. PMID:22004930

  9. The National Archives Constitution Community.

    ERIC Educational Resources Information Center

    Potter, Lee Ann

    2000-01-01

    In the summer of 1998, education specialists at the National Archives received a grant from the Department of Education to hire nine outstanding classroom teachers to develop lessons and activities based on historical documents that had been digitized by the agency and were available online. Discussion includes exploring the National Archives web…

  10. National Radiobiology Archives Distributed Access User's Manual, Version 1. 1

    SciTech Connect

    Smith, S.K.; Prather, J.C.; Ligotke, E.K.; Watson, C.R.

    1992-06-01

    This supplement to the NRA Distributed Access User's manual (PNL-7877), November 1991, describes installation and use of Version 1.1 of the software package; this is not a replacement of the previous manual. Version 1.1 of the NRA Distributed Access Package is a maintenance release. It eliminates several bugs, and includes a few new features which are described in this manual. Although the appearance of some menu screens has changed, we are confident that the Version 1.0 User's Manual will provide an adequate introduction to the system. Users who are unfamiliar with Version 1.0 may wish to experiment with that version before moving on to Version 1.1.

  11. The Archival Back Burner: Manuscript Collections and the National Archives

    ERIC Educational Resources Information Center

    Purcell, Aaron D.

    2004-01-01

    Greater access to archival materials remains a significant challenge to archivists, librarians, and researchers. In addition to official records documenting governmental activities and agencies, the National Archives and Records Administration (NARA) has significant collections of donated personal papers. Some are processed, some are in the…

  12. Standing on the Record: The National Archives.

    ERIC Educational Resources Information Center

    Crowley, Carolyn

    1984-01-01

    Profiles National Archives established by Congress in 1934 to collect and organize federal documents of permanent historic value. Types of materials included in archives, the Washington building and regional centers, the "Declaration of Independence," arrangement and preservation of materials, declassification of documents, and archives and…

  13. Broadsides & Posters from the National Archives.

    ERIC Educational Resources Information Center

    National Archives and Records Administration, Washington, DC.

    This booklet evolved from research for the exhibition "Uncle Sam Speaks: Broadsides and Posters from the National Archives," which opened at the National Archives in February 1986. The booklet is presented chronologically, beginning with broadsides from the American Revolution and ending with posters of the 1980's. Accompanying text explains the…

  14. The National Archives and Electronic Data.

    ERIC Educational Resources Information Center

    Hedlin, Edie; Harrison, Donald F.

    1988-01-01

    Discusses the events that led to the National Archives policy of preserving magnetic tapes of data generated by federal agencies and accumulating these databases as research tools. The current methods of preservation and access are described, and technical problems and archival concerns about standards are identified. (12 notes with references)…

  15. Archives and National Development in the Third World.

    ERIC Educational Resources Information Center

    Kamba, Angeline S.

    1987-01-01

    Discusses the national archives of Zimbabwe, the legislation that has directed the collection and use of the archives, the value of colonial archives in the educational process, the preservation of cultural heritage, and the formation of national policy. (CLB)

  16. NATIONAL ARCHIVE OF CRIMINAL JUSTICE DATA (NACJD)

    EPA Science Inventory

    The National Archive of Criminal Justice Data (NACJD) preserves and distributes computerized crime and justice data from Federal agencies, state agencies, and investigator initiated research projects to users for secondary statistical analysis. Founded in 1978 as part of the Inte...

  17. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Archives at College Park. The National Archives at College Park is located at 8601 Adelphi Road,...

  18. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Archives at College Park. The National Archives at College Park is located at 8601 Adelphi Road,...

  19. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Archives at College Park. The National Archives at College Park is located at 8601 Adelphi Road,...

  20. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... Archives at College Park. The National Archives at College Park is located at 8601 Adelphi Road,...

  1. NATIONAL ARCHIVE OF COMPUTERIZED DATA ON AGING

    EPA Science Inventory

    The National Archive of Computerized Data on Aging (NACDA), located within ICPSR, is funded by the National Institute on Aging. NACDA's mission is to advance research on aging by helping researchers to profit from the under-exploited potential of a broad range of datasets. NACDA ...

  2. 36 CFR 1253.2 - National Archives at College Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false National Archives at College Park. 1253.2 Section 1253.2 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... College Park. (a) The National Archives at College Park is located at 8601 Adelphi Road, College Park,...

  3. National Satellite Land Remote Sensing Data Archive

    USGS Publications Warehouse

    Faundeen, John L.; Kelly, Francis P.; Holm, Thomas M.; Nolt, Jenna E.

    2013-01-01

    The National Satellite Land Remote Sensing Data Archive (NSLRSDA) resides at the U.S. Geological Survey's (USGS) Earth Resources Observation and Science (EROS) Center. Through the Land Remote Sensing Policy Act of 1992, the U.S. Congress directed the Department of the Interior (DOI) to establish a permanent Government archive containing satellite remote sensing data of the Earth's land surface and to make this data easily accessible and readily available. This unique DOI/USGS archive provides a comprehensive, permanent, and impartial observational record of the planet's land surface obtained throughout more than five decades of satellite remote sensing. Satellite-derived data and information products are primary sources used to detect and understand changes such as deforestation, desertification, agricultural crop vigor, water quality, invasive plant species, and certain natural hazards such as flood extent and wildfire scars.

  4. 36 CFR 1280.66 - May I use the National Archives Library?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Archives Library? 1280.66 Section 1280.66 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... the Washington, DC, Area? § 1280.66 May I use the National Archives Library? The National Archives Library facilities in the National Archives Building and in the National Archives at College Park...

  5. 36 CFR 1280.66 - May I use the National Archives Library?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Archives Library? 1280.66 Section 1280.66 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... the Washington, DC, Area? § 1280.66 May I use the National Archives Library? The National Archives Library facilities in the National Archives Building and in the National Archives at College Park...

  6. 36 CFR 1280.66 - May I use the National Archives Library?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Archives Library? 1280.66 Section 1280.66 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... the Washington, DC, Area? § 1280.66 May I use the National Archives Library? The National Archives Library facilities in the National Archives Building and in the National Archives at College Park...

  7. 36 CFR 1280.66 - May I use the National Archives Library?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Archives Library? 1280.66 Section 1280.66 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... the Washington, DC, Area? § 1280.66 May I use the National Archives Library? The National Archives Library facilities in the National Archives Building and in the National Archives at College Park...

  8. 36 CFR 1280.66 - May I use the National Archives Library?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Archives Library? 1280.66 Section 1280.66 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... the Washington, DC, Area? § 1280.66 May I use the National Archives Library? The National Archives Library facilities in the National Archives Building and in the National Archives at College Park...

  9. Automating Data Submission to a National Archive

    NASA Astrophysics Data System (ADS)

    Work, T. T.; Chandler, C. L.; Groman, R. C.; Allison, M. D.; Gegg, S. R.; Biological; Chemical Oceanography Data Management Office

    2010-12-01

    In late 2006, the U.S. National Science Foundation (NSF) funded the Biological and Chemical Oceanographic Data Management Office (BCO-DMO) at Woods Hole Oceanographic Institution (WHOI) to work closely with investigators to manage oceanographic data generated from their research projects. One of the final data management tasks is to ensure that the data are permanently archived at the U.S. National Oceanographic Data Center (NODC) or other appropriate national archiving facility. In the past, BCO-DMO submitted data to NODC as an email with attachments including a PDF file (a manually completed metadata record) and one or more data files. This method is no longer feasible given the rate at which data sets are contributed to BCO-DMO. Working with collaborators at NODC, a more streamlined and automated workflow was developed to keep up with the increased volume of data that must be archived at NODC. We will describe our new workflow; a semi-automated approach for contributing data to NODC that includes a Federal Geographic Data Committee (FGDC) compliant Extensible Markup Language (XML) metadata file accompanied by comma-delimited data files. The FGDC XML file is populated from information stored in a MySQL database. A crosswalk described by an Extensible Stylesheet Language Transformation (XSLT) is used to transform the XML formatted MySQL result set to a FGDC compliant XML metadata file. To ensure data integrity, the MD5 algorithm is used to generate a checksum and manifest of the files submitted to NODC for permanent archive. The revised system supports preparation of detailed, standards-compliant metadata that facilitate data sharing and enable accurate reuse of multidisciplinary information. The approach is generic enough to be adapted for use by other data management groups.

  10. National Geophysical Data Center Tsunami Data Archive

    NASA Astrophysics Data System (ADS)

    Stroker, K. J.; Dunbar, P. K.; Brocko, R.

    2008-12-01

    NOAA's National Geophysical Data Center (NGDC) and co-located World Data Center for Geophysics and Marine Geology long-term tsunami data archive provides data and derived products essential for tsunami hazard assessment, forecast and warning, inundation modeling, preparedness, mitigation, education, and research. As a result of NOAA's efforts to strengthen its tsunami activities, the long-term tsunami data archive has grown from less than 5 gigabyte in 2004 to more than 2 terabytes in 2008. The types of data archived for tsunami research and operation activities have also expanded in fulfillment of the P.L. 109-424. The archive now consists of: global historical tsunami, significant earthquake and significant volcanic eruptions database; global tsunami deposits and proxies database; reference database; damage photos; coastal water-level data (i.e. digital tide gauge data and marigrams on microfiche); bottom pressure recorder (BPR) data as collected by Deep-ocean Assessment and Reporting of Tsunamis (DART) buoys. The tsunami data archive comes from a wide variety of data providers and sources. These include the NOAA Tsunami Warning Centers, NOAA National Data Buoy Center, NOAA National Ocean Service, IOC/NOAA International Tsunami Information Center, NOAA Pacific Marine Environmental Laboratory, U.S. Geological Survey, tsunami catalogs, reconnaissance reports, journal articles, newspaper articles, internet web pages, and email. NGDC has been active in the management of some of these data for more than 50 years while other data management efforts are more recent. These data are openly available, either directly on-line or by contacting NGDC. All of the NGDC tsunami and related databases are stored in a relational database management system. These data are accessible over the Web as tables, reports, and interactive maps. The maps provide integrated web-based GIS access to individual GIS layers including tsunami sources, tsunami effects, significant earthquakes

  11. Authority Control at the National Archives and Records Administration

    ERIC Educational Resources Information Center

    Reid, Lydia J. E.; Simmons, C. Jerry

    2007-01-01

    The National Archives and Records Administration (NARA) launched the Archival Research Catalog (ARC) in 2002. ARC was the first centralized system for describing materials held throughout NARA's nationwide system of archival repositories. ARC's complicated development involved the entire agency, as staff wrestled with years of distinct descriptive…

  12. Interim report on Landsat national archive activities

    NASA Technical Reports Server (NTRS)

    Boyd, John E.

    1993-01-01

    The Department of the Interior (DOI) has the responsibility to preserve and to distribute most Landsat Thematic Mapper (TM) and Multispectral Scanner (MSS) data that have been acquired by the five Landsat satellites operational since July 1972. Data that are still covered by exclusive marketing rights, which were granted by the U.S. Government to the commercial Landsat operator, cannot be distributed by the DOI. As the designated national archive for Landsat data, the U.S. Geological Survey's EROS Data Center (EDC) has initiated two new programs to protect and make available any of the 625,000 MSS scenes currently archived and the 200,000 TM scenes to be archived at EDC by 1995. A specially configured system has begun converting Landsat MSS data from obsolete high density tapes (HDT's) to more dense digital cassette tapes. After transcription, continuous satellite swaths are (1) divided into standard scenes defined by a world reference system, (2) geographically located by latitude and longitude, and (3) assessed for overall quality. Digital browse images are created by subsampling the full-resolution swaths. Conversion of the TM HDT's will begin in the fourth quarter of 1992 and will be conducted concurrently with MSS conversion. Although the TM archive is three times larger than the entire MSS archive, conversion of data from both sensor systems and consolidation of the entire Landsat archive at EDC will be completed by the end of 1994. Some MSS HDT's have deteriorated, primarily as a result of hydrolysis of the pigment binder. Based on a small sample of the 11 terabytes of post-1978 MSS data and the 41 terabytes of TM data to be converted, it appears that to date, less than 2 percent of the data have been lost. The data loss occurs within small portions of some scenes; few scenes are lost entirely. Approximately 10,000 pre-1979 MSS HDT's have deteriorated to such an extent, as a result of hydrolysis, that the data cannot be recovered without special treatment of

  13. 36 CFR 1253.1 - National Archives Building.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false National Archives Building. 1253.1 Section 1253.1 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE LOCATION OF NARA FACILITIES AND HOURS OF USE § 1253.1 National...

  14. 36 CFR 1253.1 - National Archives Building.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... hours of the Office of the Federal Register are located in 1 CFR 2.3. ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false National Archives Building. 1253.1 Section 1253.1 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS...

  15. 36 CFR 1253.1 - National Archives Building.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... exhibit areas of the building will be no later than 30 minutes before the stated closing hour. The phone number for the National Archives Building is 202-357-5000. ... Building. The National Archives Building is located at 700 Pennsylvania Avenue, NW., Washington, DC...

  16. 36 CFR 1253.1 - National Archives Building.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... exhibit areas of the building will be no later than 30 minutes before the stated closing hour. The phone number for the National Archives Building is 202-357-5000. ... Building. The National Archives Building is located at 700 Pennsylvania Avenue, NW., Washington, DC...

  17. 36 CFR 1253.1 - National Archives Building.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... exhibit areas of the building will be no later than 30 minutes before the stated closing hour. The phone number for the National Archives Building is 202-357-5000. ... Building. The National Archives Building is located at 700 Pennsylvania Avenue, NW., Washington, DC...

  18. National Radiobiology Archives Distributed Access User`s Manual, Version 1.1. Revision 1

    SciTech Connect

    Smith, S.K.; Prather, J.C.; Ligotke, E.K.; Watson, C.R.

    1992-06-01

    This supplement to the NRA Distributed Access User`s manual (PNL-7877), November 1991, describes installation and use of Version 1.1 of the software package; this is not a replacement of the previous manual. Version 1.1 of the NRA Distributed Access Package is a maintenance release. It eliminates several bugs, and includes a few new features which are described in this manual. Although the appearance of some menu screens has changed, we are confident that the Version 1.0 User`s Manual will provide an adequate introduction to the system. Users who are unfamiliar with Version 1.0 may wish to experiment with that version before moving on to Version 1.1.

  19. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 680-A-1). Part of ground floor as built; 1936. - Mare Island Naval Shipyard, Machine Shop, California Avenue, southwest corner of California Avenue & Thirteenth Street, Vallejo, Solano County, CA

  20. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 521-A-1). Ground floor and roof plans; May 1941. - Mare Island Naval Shipyard, Administrative Offices, Walnut Avenue, east side between Seventh & Eighth Streets, Vallejo, Solano County, CA

  1. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 253-A-2). Mill work; October 1918. - Mare Island Naval Shipyard, Supply Building, Walnut Avenue, southeast corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  2. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 253-A-1). Plans elevations, sections and details; September 1918. - Mare Island Naval Shipyard, Supply Building, Walnut Avenue, southeast corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  3. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # P-A-4). Alterations; June 6, 1941. - Mare Island Naval Shipyard, Quarters P, Walnut Avenue, northwest corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  4. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 680-A-10). Machine shop door as built, details; 1938. - Mare Island Naval Shipyard, Machine Shop, California Avenue, southwest corner of California Avenue & Thirteenth Street, Vallejo, Solano County, CA

  5. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-72-A-9). Miscellaneous details; N.D. - Mare Island Naval Shipyard, Hospital Wards, Cedar Avenue, eat side between Fourteenth Avenue & Cossey Street, Vallejo, Solano County, CA

  6. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-72-A-8). Cross sections; N.D. - Mare Island Naval Shipyard, Hospital Wards, Cedar Avenue, eat side between Fourteenth Avenue & Cossey Street, Vallejo, Solano County, CA

  7. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-72-A-6). Exterior elevations; N.D. - Mare Island Naval Shipyard, Hospital Wards, Cedar Avenue, eat side between Fourteenth Avenue & Cossey Street, Vallejo, Solano County, CA

  8. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-72-A-7). Cross sections; N.D. - Mare Island Naval Shipyard, Hospital Wards, Cedar Avenue, eat side between Fourteenth Avenue & Cossey Street, Vallejo, Solano County, CA

  9. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-72-A-5). Exterior elevations; N.D. - Mare Island Naval Shipyard, Hospital Wards, Cedar Avenue, eat side between Fourteenth Avenue & Cossey Street, Vallejo, Solano County, CA

  10. 14. Photocopy of drawing (Original in collection of National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of drawing (Original in collection of National Archives, # 121-BA-9373D) Delineator unknown, date unknown FOURTH FLOOR PLAN - U.S. Post Office Department, 1100 Pennsylvania Avenue Northwest, Washington, District of Columbia, DC

  11. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 208-A-5) Remodeling for cafeteria; May 6, 1954. - Mare Island Naval Shipyard, Administrative Offices & Cafeteria, Twelfth Street, north side between Railroad Avenue & Cedar Aveneu, Vallejo, Solano County, CA

  12. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 505-A-3). Floor plan; October, 1938. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  13. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 505-A-10). Exterior details; October, 1938. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  14. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 505-A-14). Door schedule and details; October, 1938 - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  15. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 505-A-6). Elevations and sections; October 1938. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  16. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 505-A-9). Entrance details; October, 1938. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  17. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 505-A-16). Window details (as built); October, 1938. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  18. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 505-A-11). Tower and stair details; October, 1938. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  19. 6. Photocopy of map (from National Archives, Cartographic Division, Record ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Photocopy of map (from National Archives, Cartographic Division, Record Group 77) Delineator unknown 1863 'MAP OF THE U.S. MILITARY RESERVE AT BENICIA CAL' - Benicia Arsenal, Benicia Industrial Park, Benicia, Solano County, CA

  20. 8. Photocopy of drawing (Original in possession of National Archives ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of drawing (Original in possession of National Archives and Record Service, Record Group 92) Delineator unknown, Date unknown BASEMENT FLOOR PLAN - Omaha Quartermaster Depot Historic District, Twenty-second & Woolworth Streets, Omaha, Douglas County, NE

  1. 9. Photocopy of drawing (Original in possession of National Archives ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photocopy of drawing (Original in possession of National Archives and Record Service, Record Group 92) Delineator unknown, Date unknown FIRST FLOOR PLAN - Omaha Quartermaster Depot Historic District, Twenty-second & Woolworth Streets, Omaha, Douglas County, NE

  2. 10. Photocopy of drawing (Original in possession of National Archives ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photocopy of drawing (Original in possession of National Archives and Record Service, Record Group 92) Delineator unknown, Date unknown SECOND FLOOR PLAN - Omaha Quartermaster Depot Historic District, Twenty-second & Woolworth Streets, Omaha, Douglas County, NE

  3. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-19). Plan of monorail; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  4. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-5). Sections & Details; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  5. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-2). Existing conditions; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  6. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-13). Crane door details: August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  7. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-6). Door details; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  8. Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy.

    PubMed

    Held, Kathryn D; Blakely, Eleanor A; Story, Michael D; Lowenstein, Derek I

    2016-06-01

    Although clinical studies with carbon ions have been conducted successfully in Japan and Europe, the limited radiobiological information about charged particles that are heavier than protons remains a significant impediment to exploiting the full potential of particle therapy. There is growing interest in the U.S. to build a cancer treatment facility that utilizes charged particles heavier than protons. Therefore, it is essential that additional radiobiological knowledge be obtained using state-of-the-art technologies and biological models and end points relevant to clinical outcome. Currently, most such ion radiotherapy-related research is being conducted outside the U.S. This article addresses the substantial contributions to that research that are possible at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), which is the only facility in the U.S. at this time where heavy-ion radiobiology research with the ion species and energies of interest for therapy can be done. Here, we briefly discuss the relevant facilities at NSRL and how selected charged particle biology research gaps could be addressed using those facilities. PMID:27195609

  9. National Wind Tunnel Complex (NWTC) Project Archive

    NASA Technical Reports Server (NTRS)

    1996-01-01

    This archive was designed with three purposes in mind. First, it was designed as a medium for providing our program deliverables to our customers-NASA and the industry team. Secondly, it was designed to be "The" critical resource for a program restart. Finally, the archive should serve as an invaluable technical resource for aerodynamic and wind tunnel science. The documents are stored in both native format and, for the majority of the documents, in scanned format. The end user is responsible for having applications for viewing and using native and scanned format documents.

  10. National Human Radiobiological Tissue Repository (NHRTR) at the United States Transuranium and Uranium Registries

    DOE Data Explorer

    The NHRTR, one component of the USTUR, contains frozen tissues, tissue solutions, microscope slides, and paraffin blocks that were collected by the USTUR at the autopsy of workers with documented intakes of plutonium, americium, uranium, and thorium. The samples are available to qualified scientists for further research. Thousands of frozen, ashed, dried, and plastic embedded bone samples from the radium studies carried out by Argonne National Laboratory, Argonne Cancer Research Hospital, the Massachusetts Institute of Technology, and the New Jersey Radium Research Project are available and linked by case number to de-identified, published case data. These data include the person's source of exposure (dial painter, therapeutic injection, etc.), estimated body burden, radiochemical results, and medical history. Other samples, including organs and whole body donations, have come from volunteer donors who were impacted by elements such as plutonium, throium, etc. See the USTUR website for information on how to apply for research samples or how to become a volunteer donor. [Information taken from http://www.ustur.wsu.edu/NHRTR/index.html#

  11. The long hold: Storing data at the National Archives

    NASA Technical Reports Server (NTRS)

    Thibodeau, Kenneth

    1992-01-01

    The National Archives is, in many respects, in a unique position. For example, I find people from other organizations describing an archival medium as one which will last for three to five years. At the National Archives, we deal with the centuries, not years. From our perspective, there is no archival medium for data storage, and we do not expect there will ever be one. Predicting the long-term future of information technology beyond a mere five or ten years approaches the occult arts. But one prediction is probably safe. It is that the technology will continue to change, at least until analysts start talking about the post-information age. If we did have a medium which lasted a hundred years or longer, we probably would not have a device capable of reading it. The issue of obsolescence, as opposed to media stability, is more complex and more costly. It is especially complex at the National Archives because of two other aspects of our peculiar position. The first aspect is that we deal with incoherent data. The second is that we are charged with satisfying unknown and unknowable requirements. A brief overview of these aspects is presented.

  12. Sound Recordings in the Audiovisual Archives Division of the National Archives. Preliminary Draft.

    ERIC Educational Resources Information Center

    Bray, Mayfield S.; Waffen, Leslie C.

    Some 47,000 sound recordings dating from the turn of the century have been collected in the National Archives. These recordings, consisting of recordings of press conferences, panel discussions, interviews, speeches, court and conference proceedings, entertainment programs, and news broadcasts, are listed in this paper by government agency. The…

  13. NASA's astrophysics archives at the National Space Science Data Center

    NASA Technical Reports Server (NTRS)

    Vansteenberg, M. E.

    1992-01-01

    NASA maintains an archive facility for Astronomical Science data collected from NASA's missions at the National Space Science Data Center (NSSDC) at Goddard Space Flight Center. This archive was created to insure the science data collected by NASA would be preserved and useable in the future by the science community. Through 25 years of operation there are many lessons learned, from data collection procedures, archive preservation methods, and distribution to the community. This document presents some of these more important lessons, for example: KISS (Keep It Simple, Stupid) in system development. Also addressed are some of the myths of archiving, such as 'scientists always know everything about everything', or 'it cannot possibly be that hard, after all simple data tech's do it'. There are indeed good reasons that a proper archive capability is needed by the astronomical community, the important question is how to use the existing expertise as well as the new innovative ideas to do the best job archiving this valuable science data.

  14. Photocopy of drawing (original located at the National Archives, San ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing (original located at the National Archives, San Bruno, California, Navy # A1-3). Ordnance Dept. of Navy Yard Mare Island "Magazine no. 1 - general plan of proposal. September, 1901 - Mare Island Naval Shipyard, Magazine No. 1, Railroad Avenue, west side near Maseda Road, Vallejo, Solano County, CA

  15. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 680-A-2). Part of ground floor, optical shop and roof periscope testing tower; 1936. - Mare Island Naval Shipyard, Machine Shop, California Avenue, southwest corner of California Avenue & Thirteenth Street, Vallejo, Solano County, CA

  16. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 121-A-23). PW Minsy Building 121 record ground floor plan; N.D. - Mare Island Naval Shipyard, Central Power Plant, California Avenue, norhtwest corner of California Avenue & Seventh Street, Vallejo, Solano County, CA

  17. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 46-A-16). Department Navy NAVFAC minsy "building 46-north and west elevations; June 30, 1977. - Mare Island Naval Shipyard, Smithery, California Avenue, west side at California Avenue & Eighth Street, Vallejo, Solano County, CA

  18. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 46-A-11). Dept. Navy Navfac Minsy "Building no. 46 extension of office, architectural; October 12, 1968. - Mare Island Naval Shipyard, Smithery, California Avenue, west side at California Avenue & Eighth Street, Vallejo, Solano County, CA

  19. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 106-A-17). NAVFAC relocated sail loft building 106 1st floor plan; sail loft area, August 1, 1977. - Mare Island Naval Shipyard, Boat Shop, California Avenue, west side between Ninth & Tenth Streets, Vallejo, Solano County, CA

  20. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 46-A-17). Department Navy Navfac minsy "building 46 - north (inside of "U") and south elevations;" June 30, 1972. - Mare Island Naval Shipyard, Smithery, California Avenue, west side at California Avenue & Eighth Street, Vallejo, Solano County, CA

  1. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 106-A-18). NAVFAC, relocate sail, loft, building 106 1st floor plan, boat shop. August 2, 1977. - Mare Island Naval Shipyard, Boat Shop, California Avenue, west side between Ninth & Tenth Streets, Vallejo, Solano County, CA

  2. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 106-A-27). NAVFAC building 106 and 106A miscellaneous repairs-elevations; June 8, 1987. - Mare Island Naval Shipyard, Boat Shop, California Avenue, west side between Ninth & Tenth Streets, Vallejo, Solano County, CA

  3. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 52-A-20). Department of Navy, Navfac Minsy Vallejo Calif, Bldg. 52 - Elevations; June 30, 1977. - Mare Island Naval Shipyard, No. 70 Iron Platers, California Avenue, west side across from Drydock 1 near Ninth Street, Vallejo, Solano County, CA

  4. 3. Photocopy of architectural drawings (from National Archives, Cartographic Division, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of architectural drawings (from National Archives, Cartographic Division, Record Group 156, Folder 1) Delineator unknown January, 1869 'U.S. OFFICES BENICIA ARSENAL, ROOF PLAN, SECOND FLOOR PLAN, GROUND PLAN, BASEMENT PLAN' - Benicia Arsenal, Office Building, M Street vicinity, Benicia, Solano County, CA

  5. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 253-A-3). (6079235) 76-C-8977 sealing & painting bldg. 253, architectural-exterior, elevations & key plan; August 10, 1976. - Mare Island Naval Shipyard, Supply Building, Walnut Avenue, southeast corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  6. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-22), showing current floor plan. Department of the Navy, Bureau of Yards and Docks, "Record drawing, N.D. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  7. 8. Photocopy of sketch from National Archives, Record Group 121, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of sketch from National Archives, Record Group 121, Box 123, Folder 1877-1886 Filed with telegram for Secretary of Treasury from J.V. Harris, Collector, March 30, 1886 SECOND-FLOOR PLAN - U. S. Navy Coal Depot & Storehouse, Front & Whitehead Streets, Key West, Monroe County, FL

  8. National Archives and Records Administration Community College Program.

    ERIC Educational Resources Information Center

    National Archives and Records Service (GSA), Washington, DC.

    Information is provided on the U.S. National Archives' Community College Program (CCP). First, a program announcement is provided, which indicates that the CCP provides reproductions of primary sources to community, technical and junior college instructors teaching occupational and transfer degree programs. This announcement lists the kinds of…

  9. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 459-A-12). MARBLE AND TILE DETAILS; DECEMBER, 1930 - Mare Island Naval Shipyard, Bachelor Enlisted Quarters & Offices, Walnut Avenue, east side between D Street & C Street, Vallejo, Solano County, CA

  10. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-20). Navy Yard Mare Island prison extension building no. 84 washing and drying room - architectural and electrical plan, elevations and details; October 12, 1942. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  11. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # DD 1-D-25). Cross section through centre of stone dry dock Navy Yard Mare Island; July 22, 1892. - Mare Island Naval Shipyard, Drydock No. 1, California Avenue, east side near Ninth Street, Vallejo, Solano County, CA

  12. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-4, showing organ recess. Dept. yards & docks, U.S. Navy, Mare Island, Cal., "Plan & Sections, proposed addition, St. Peter's Chapel, December 1904 - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  13. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-5). Depts. Yards & docks, U.S. Navy Mare Island, Cal., "full sized detail of fretwork panels in back of organ recess, St. Peter's Chapel, Mare Island, Cal., December 1904. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  14. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-7. "Full size sketch of 2 candelabra stands for St. Peters Chapel, Mare Island, Calif.," October 1908. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  15. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # U-A-1). Dept PW, US Navy Yard Mare Island, Calif. alternative quarters for officers in charge plans, plans elevations, and sections; May 1921. - Mare Island Naval Shipyard, Quarters U, Cedar Avenue, west side between Tenth Street & Walnut Avenue, Vallejo, Solano County, CA

  16. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy #A-A-A-5). SERVANTS HOUSE (AA) QUARTERS A; DECEMBER 28, 1936, AND JULY 7, 1950. - Mare Island Naval Shipyard, Quarters A-A, Walnut Avenue behind Quarters A, west side near Eighth Street, Vallejo, Solano County, CA

  17. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # P-A-2). Quarters P U.S. Navy Yard Mare Island Cal elevations, porch and screening, October, 1911. - Mare Island Naval Shipyard, Quarters P, Walnut Avenue, northwest corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  18. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # P-A-3.) Navy yard mare island, cal quarters P. conditions as of 3-22-27; March 22, 1937. - Mare Island Naval Shipyard, Quarters P, Walnut Avenue, northwest corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  19. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-14). Dept. of yards and docks, "Chapel amplifier support," October 1945. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  20. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 52-A-1). Design for iron plating shop at Navy Yard, Mare Island; floor plan; N.D. - Mare Island Naval Shipyard, No. 70 Iron Platers, California Avenue, west side across from Drydock 1 near Ninth Street, Vallejo, Solano County, CA

  1. Photocopy of drawing located at National Archives, San Bruno. California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno. California (Navy #231-A-1). DEPT. PW US NAVY YARD MARE ISLAND CAL "STABLE - U.S. NAVY YARD MARE ISLAND CAL;" DECEMBER, 1917. - Mare Island Naval Shipyard, Transportation Building & Gas Station, Third Street, south side between Walnut Avenue & Cedar Avenue, Vallejo, Solano County, CA

  2. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-72-A-11). Stairs elevator hatch and solarium; N.D. - Mare Island Naval Shipyard, Hospital Wards, Cedar Avenue, eat side between Fourteenth Avenue & Cossey Street, Vallejo, Solano County, CA

  3. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-72-A-13). Ground and basement plans; N.D. - Mare Island Naval Shipyard, Hospital Wards, Cedar Avenue, eat side between Fourteenth Avenue & Cossey Street, Vallejo, Solano County, CA

  4. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-72-A-3). Typical floor plan - first, second and third; N.D. - Mare Island Naval Shipyard, Hospital Wards, Cedar Avenue, eat side between Fourteenth Avenue & Cossey Street, Vallejo, Solano County, CA

  5. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 110-A-3). Stone and concrete dry-dock for the U.S. Navy Yard, Mare Island, modified plan, pumping plant; March, 1903. - Mare Island Naval Shipyard, Pump House, California Avenue, east side between Dry Dock 1 & Dry Dock 2, near Ninth Street, Vallejo, Solano County, CA

  6. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 110-A-2). Stone and concrete dry-dock for the U.S. Navy Yard, Mare Island, modified plan, pumping plant; March, 1903. - Mare Island Naval Shipyard, Pump House, California Avenue, east side between Dry Dock 1 & Dry Dock 2, near Ninth Street, Vallejo, Solano County, CA

  7. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-28). PW Dept, US Navy Yard Mare Island Cal U.S. Naval Hospital reconstruction - building H-1 plans of basement & first floor, January, 1924. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  8. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-29). PW Dept. US Navy Yard Mare Island Cal. U.S. Naval Hospital reconstruction - building H-1 plans of 2nd and 3rd floors, January, 1924. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  9. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-1), showing ground plan. Albert Sutton, plan for yard chapel at U.S. Navy Yard, Mare Island, Cal., November 1900. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  10. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-2), showing front elevation and section. Albert Sutton, plan for yard chapel at U.S. Navy Yard, Mare Island, Cal., November 1900. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  11. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-3, showing side and rear elevation. Albert Sutton, "plan for yard chapel at the U.S. Navy Yard, Mare Island, Cal.," November 1900. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  12. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-5). Proposed toilets for the Naval prison at the Navy Yard, Mare Island, Calif., plans, sections, elevation. August 18, 1902. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  13. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-14). PW Navy Yard Mare Island. Cal building 84A - prison extension for mess hall and galley, elevations and window details; October 18, 1938. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  14. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-9). Dept of Y & D U.S. Navy Yard Mare Island, Cal prison extension bldg. 84, plans; April 4, 1908. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  15. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-21). Mare Island Naval shipyard, Vallejo California building no. 84 and 84-A layout plan for print shop, July 3, 1953. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  16. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-11). Dept of Y & D U.S. Navy Yard Mare Island, Cal prison extension bldg 84, elevations; April 4, 1908. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  17. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-8). Department of yards and docks, U.S. Navy Yard Mare Island, Cal prison at barracks plans and elevations; December 1907. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  18. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-3). Additional to Naval prison - U.S. Navy Yard Mare Island Cal plans and cross section; April, 1901. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  19. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-7). Proposed additional cells for naval prison bldg. no 84 at the U.S. Navy Yard Mare Island, Cal. Plan and section; October 28, 1902. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  20. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-1). Plan of naval prison at the U.S. Navy Yard, Mare Island, Cal plans and elevations; CA. 1870. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  1. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 84-A-2). Budocks additions to naval prison U.S. Navy Yard Mare Island Cal, elevations; April, 1909. - Mare Island Naval Shipyard, Marine Prison, Suisun Avenue, west side between Mesa Road & San Pablo, Vallejo, Solano County, CA

  2. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # MI-A-6). Dept. PW, US Navy Yard Mare Island, Calif. US Marine reconstruction, remodeling and rebuilding quarters M-1 details, N.D. - Mare Island Naval Shipyard, Quarters M1, Preston Street, south side adjacent to Marine Parade Grounds, Vallejo, Solano County, CA

  3. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # MI-A-E-5). Dept PW, US Navy Yard Mare Island Calif. U.S. Marine reconstruction remodeling, rebuilding quarters M-1 plans and elevations; April, 1922. - Mare Island Naval Shipyard, Quarters M1, Preston Street, south side adjacent to Marine Parade Grounds, Vallejo, Solano County, CA

  4. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 46-A-1). Public works Navy Yard Mare Island California "remodeling building 36, 40, 42, and 48 for pipe and copper shop, general plan building 46;" November 13, 1931. - Mare Island Naval Shipyard, Smithery, California Avenue, west side at California Avenue & Eighth Street, Vallejo, Solano County, CA

  5. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy#G-A-1). "NAVY YARD MARE ISLAND QUARTERS G REMODELING PLANS;" 1937. - Mare Island Naval Shipyard, Quarters G, Walnut Avenue, west side between Ninth & Tenth Streets, Vallejo, Solano County, CA

  6. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy #G-A-2). "NAVY YARD MARE ISLAND QUARTERS G REMODELING ELEVATIONS;" 1937. - Mare Island Naval Shipyard, Quarters G, Walnut Avenue, west side between Ninth & Tenth Streets, Vallejo, Solano County, CA

  7. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-8). Additions to Naval Hospital Mare Island Cal foundations plans; 1909. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  8. 7. Photographic copy of photograph (Source: National Archives, Rocky Mountain ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of photograph (Source: National Archives, Rocky Mountain Region, Denver, Salt River Project History, Final History to 1916. p. 506) Interior view of transformer house. No date. CA. 1916. - Theodore Roosevelt Dam, Transformer House, Salt River, Tortilla Flat, Maricopa County, AZ

  9. 7. Photographic copy of photograph (Source: National Archives, Rocky Mountain ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photographic copy of photograph (Source: National Archives, Rocky Mountain Region, Denver, Salt River Project History, Final History to 1916. p. 504) Inside Roosevelt power plant showing size of valve. CA. 1916. - Theodore Roosevelt Dam, Power Plant, Salt River, Tortilla Flat, Maricopa County, AZ

  10. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-5). U.S. Naval Hospital at Mare Island Ca sections and longitudinal sections; N.D. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  11. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-10). Additions to Naval Hospital Mare Island Cal second and third floor plans; November 24, 1909. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  12. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-11). Additions to Naval Hospital Mare Island Cal scale details; 1909. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  13. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-12). Additions to Naval Hospital Mare Island Cal section through stairway, 1909. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  14. Photocopy of drawing located at National Archives, San Bruno California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno California (Navy# H-1-A-9). Additions to Naval Hospital Mare Island Cal basement and first floor plan; November 25, 1909. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  15. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-4). U.S. Naval Hospital at Mare Island transverse sections; N.D. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  16. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # H-1-A-15). Additions to Naval Hospital Mare Island Cal details of fireplace; 1909. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

  17. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # NUM), showing 680-A-9. Machine shop expansion joint and details; 1938. - Mare Island Naval Shipyard, Machine Shop, California Avenue, southwest corner of California Avenue & Thirteenth Street, Vallejo, Solano County, CA

  18. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy #926-A-12). Exterior stairs on ends on wings-details; N.D. - Mare Island Naval Shipyard, Wilderman Hall, Johnson Lane, north side adjacent to (south of) Hospital Complex, Vallejo, Solano County, CA

  19. 11. Photocopy of architectural drawing (from National Archives Architectural and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of architectural drawing (from National Archives Architectural and Cartographic Branch Alexandria, Va.) 'Non-Com-Officers Qrs.' Quartermaster General's Office Standard Plan 82, sheet 1. Lithograph on linen architectural drawing. April 1893 3 ELEVATIONS, 3 PLANS AND A PARTIAL SECTION - Fort Myer, Non-Commissioned Officers Quarters, Washington Avenue between Johnson Lane & Custer Road, Arlington, Arlington County, VA

  20. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # A-21). Dept. of the Navy District Public Works Office, "additions, floor plan, elevations & details; architectural, mechanical & electrical," May 1963. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  1. 12. Photocopy of architectural drawing (from National Archives Architectural and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopy of architectural drawing (from National Archives Architectural and Cartographic Branch, Alexandria, Va.) 'Non-Com-Officers Qrs.' Quartermaster Generals Office Standard Plan 82, sheet 2, April 1893. Lithograph on linen architectural drawing. DETAILS - Fort Myer, Non-Commissioned Officers Quarters, Washington Avenue between Johnson Lane & Custer Road, Arlington, Arlington County, VA

  2. 9. Photocopy of architectural drawing (from National Archives Architectural and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photocopy of architectural drawing (from National Archives Architectural and Cartographic Branch, Alexandria, Va.) Annotated lithograph on paper. Standard plan used for construction of Commissary Sergeants Quarters, 1876. PLAN, FRONT AND SIDE ELEVATIONS, SECTION - Fort Myer, Commissary Sergeant's Quarters, Washington Avenue between Johnson Lane & Custer Road, Arlington, Arlington County, VA

  3. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-25) William Jeffries Associates, A.I.A., "Repair to stained glass window, building 104, elevation & details," September 1952. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  4. 7. Photocopy of map (from National Archives, Cartographic Division, Record ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photocopy of map (from National Archives, Cartographic Division, Record Group 156, Folder 3) 'Surveyed and Drawn by Hugo Hochholzer' 1868 'TOPOGRAPHICAL MAP OF THE U.S. MILITARY RESERVE AT BENICIA CAL.' - Benicia Arsenal, Benicia Industrial Park, Benicia, Solano County, CA

  5. 5. Photocopy of map (from National Archives, Cartographic Division, Record ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Photocopy of map (from National Archives, Cartographic Division, Record Group 77, Dr. 124, sht. 19-1) 'Drawn and sketched by Robt. Redmayne' February 20th, 1856 'A MAP OF THE U.S. MILITARY RESERVE AT BENICIA CAL.' - Benicia Arsenal, Benicia Industrial Park, Benicia, Solano County, CA

  6. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-9). (Signed) Ralph Whitman, public works officer, "Yard chapel addition to house organ, etc., plans, elevations, details," September 1929. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  7. Photocopy of original drawings (original located at the National Archives, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of original drawings (original located at the National Archives, San Bruno, California, Navy # 104-A-13). (Signed) Ralph Whitman, public works officer, "Yard chapel organ addition mill details, exterior window," September 1929. - Mare Island Naval Shipyard, St. Peter's Chapel, Walnut Street & Cedar Parkway, Vallejo, Solano County, CA

  8. Photocopy of drawing located at National Archives. San Bruno. California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives. San Bruno. California (Navy #29-A-1). NAVY YARD MARE ISLAND, CAL "QUARTERS NO. 29 AND NO. 133 RELOCATION PLOT PLAN AND FOUNDATION DETAIL;" FEBRUARY 1. 1933. - Mare Island Naval Shipyard, Quarters 29, Walnut Avenue, west side between Third & Fifth Streets, Vallejo, Solano County, CA

  9. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-1). Plot plan railroads and paving; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  10. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy 271-A-17). Minsy building 271 record 1st floor plan; N.D. - Mare Island Naval Shipyard, Mechanics Shop, Waterfront Avenue, west side between A Street & Third Street, Vallejo, Solano County, CA

  11. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California ( Navy # M37-A-20). Budocks porch screens and sash sums barracks, US Navy Yard Mare Island, Cal. May, 1916. - Mare Island Naval Shipyard, Marine Barracks, Cedar Avenue, west side between Twelfth & Fourteenth Streets, Vallejo, Solano County, CA

  12. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-15). First floor & mess framing; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  13. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-3). Second floor and roof plan; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  14. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-12). Elevations and crane door; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  15. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # A266-4). Elevations and window schedules; August 25, 1944. - Mare Island Naval Shipyard, Ordnance Warehouse, Blake Avenue, northeast corner of Blake Avenue & Railroad Avenue, Vallejo, Solano County, CA

  16. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California {Navy #Q1-A-3). BUDOCKS "NAVY YARD MARE ISLAND, CALIFORNIA. OFFICERS QUARTERS (10 UNITS) ELEVATIONS;" SEPTEMBER 11, 1941. - Mare Island Naval Shipyard, Quarters 1-2, Cedar Avenue, southeast corner of Cedar Avenue & Seventh Street, Vallejo, Solano County, CA

  17. 21 CFR 21.31 - Records stored by the National Archives and Records Administration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Records stored by the National Archives and... § 21.31 Records stored by the National Archives and Records Administration. (a) Food and Drug Administration records that are stored, processed, and serviced by the National Archives and...

  18. 36 CFR 1280.62 - When are the exhibit areas in the National Archives Building open?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the National Archives Building open? 1280.62 Section 1280.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Are the Additional... National Archives Building open? The exhibit areas are open to the public from 10 a.m. until 5:30 p.m....

  19. 21 CFR 21.31 - Records stored by the National Archives and Records Administration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Records stored by the National Archives and... § 21.31 Records stored by the National Archives and Records Administration. (a) Food and Drug Administration records that are stored, processed, and serviced by the National Archives and...

  20. 36 CFR 1280.62 - When are the exhibit areas in the National Archives Building open?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the National Archives Building open? 1280.62 Section 1280.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Are the Additional... National Archives Building open? (a) The exhibit areas' hours of operation are posted at...

  1. 36 CFR 1280.62 - When are the exhibit areas in the National Archives Building open?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the National Archives Building open? 1280.62 Section 1280.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Are the Additional... National Archives Building open? (a) The exhibit areas' hours of operation are posted at...

  2. 36 CFR 1280.62 - When are the exhibit areas in the National Archives Building open?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the National Archives Building open? 1280.62 Section 1280.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Are the Additional... National Archives Building open? (a) The exhibit areas' hours of operation are posted at...

  3. 36 CFR 1280.62 - When are the exhibit areas in the National Archives Building open?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the National Archives Building open? 1280.62 Section 1280.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Are the Additional... National Archives Building open? (a) The exhibit areas' hours of operation are posted at...

  4. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 47-A-3). "Proposed alteration of office building at The U.S. Navy Yard Mare Island Cal proposed alterations of 1st and 2nd stories to accompany the report of the board of which pay director bacon is the senior member;" September, 1901. - Mare Island Naval Shipyard, Old Administrative Offices, Eighth Street, north side between Railroad Avenue & Walnut Avenue, Vallejo, Solano County, CA

  5. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 110-A-1 1 of 5. Scofiled Construction Company Mafre Island Office, Mare Island Cal. Details of skylight for pump house stone and concrete dry-dock for US Navy Yard Mare Island Cal, contract no. 257; September 2, 1908. - Mare Island Naval Shipyard, Pump House, California Avenue, east side between Dry Dock 1 & Dry Dock 2, near Ninth Street, Vallejo, Solano County, CA

  6. Photocopy of drawing located at National Archives, San Bruno, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photocopy of drawing located at National Archives, San Bruno, California (Navy # 52-A-3). Proposed plan for changing galley floor, west end of building no. 52 into a patton shop for the C&R Department at the U.S. Navy Yard Mare Island, Cal, plans and elevations; August, 1900 - Mare Island Naval Shipyard, No. 70 Iron Platers, California Avenue, west side across from Drydock 1 near Ninth Street, Vallejo, Solano County, CA

  7. The Role of Archives and Records Management in National Information Systems: A RAMP Study.

    ERIC Educational Resources Information Center

    Rhoads, James B.

    Produced as part of the United Nations Educational, Scientific, and Cultural Organization (UNESCO) Records and Archives Management Programme (RAMP), this publication provides information about the essential character and value of archives and about the procedures and programs that should govern the management of both archives and current records,…

  8. 36 CFR 1280.60 - Where do I enter the National Archives Building in Washington, DC?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Archives Building in Washington, DC? 1280.60 Section 1280.60 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Are the Additional Rules... Archives Building in Washington, DC? (a) To conduct research or official business, you must enter...

  9. 10. Photocopy of map (from National Archives Architectural and Cartographic ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photocopy of map (from National Archives Architectural and Cartographic Branch, Alexandria, Va.) 'Fort Myer Virginia', 'Quartermaster Generals Office, Dec. 1894' MAP SHOWS (upper center) BUILDING 42, (labeled 5) BUILDING 43 (labeled 6), PROPOSED OFFICERS QUARTERS, (not built, but later site of Building 44 moved from NE of this group, and labeled on map 37), BUILDING 45 (labeled 29) (added to map at time of construction, 1895) BUILDING 46 (labeled 51) MAP SHOWS HISTORICAL PERIOD LAYOUT, BUILDINGS, STREETS, TROLLEY LINE AND WATER AND SEWER LINES - Fort Myer, Commissary Sergeant's Quarters, Washington Avenue between Johnson Lane & Custer Road, Arlington, Arlington County, VA

  10. Historical earthquake data in record groups of Slovene National Archives

    NASA Astrophysics Data System (ADS)

    Kosir, M.; Cecic, I.

    2003-04-01

    Slovene earthquake catalogue is under the process of reevaluation. Therefore, for strong historical events it is necessary to check the existing data and at the same time try to find some new information about known and yet unknown significant events. A historian is presently inspecting the material of the National Archives for the period 1500--1800. In comparison to older period, historical sources from the beginning of the 16th century, kept at the National Archives of Slovenia, have considerably increased in number, due to the spreading of records management and increase in the number of offices and official clerks. Records at the archive are arranged according to record groups, which means by institutions, organizations or individuals that created records. For the period from 1500 to 1747 the most important record groups are those of Carniolian Estates and Carniolian Vizdom that include data regarding the activities of the provincial agencies. Record groups of individual land estates are also of great interest although less extensive. Card files and indexes examined so far indicate an interesting portray. Among sources dealing with catastrophes of that time we find mostly information on fires and floods, less numerous are those describing earthquakes. The search is furthermore made more difficult since the information on earthquakes was not explicitely included in descriptions under independent subjects such as fires or floods, but was mostly hidden under subjects connected to building renovation and similar. In general, data on earthquakes are rather scattered. Regardless of the rarity of such data it is expected that the search will discover new data about known and unknown historical events in Slovenia.

  11. From the Leaders of Our Nation: Prime Ministers' Records at the National Archives

    ERIC Educational Resources Information Center

    Shapley, Maggie

    2005-01-01

    The National Archives of Australia holds the papers of many of "Australia's Prime Ministers," including Bruce, Lyons, Curtin, Chifley, Holt, Whitlam, Fraser, Hawke, Keating and Howard. From 2000 it undertook a four-year Prime Ministers' Papers Project to locate the records of all 25 men who have held the position of Prime Minister of Australia.…

  12. 36 CFR 1235.30 - How may records in the National Archives of the United States be used?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... National Archives of the United States be used? 1235.30 Section 1235.30 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL... National Archives of the United States be used? (a) NARA will enforce restrictions that are consistent...

  13. Another New Frontier: Archives and Manuscripts in the National Park Service.

    ERIC Educational Resources Information Center

    Bowling, Mary B.

    1985-01-01

    Archival collections of Edison, Olmsted, Morristown, and Longfellow National Historic Sites offer examples of how documentary collections have been handled in the past, and of ways in which National Park Service is beginning to address cultural resource management issues (arrangement, preservation, cataloging, research use) of archives and…

  14. 3 CFR - Designation of Officers of the National Archives and Records Administration To Act as Archivist...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 3 The President 1 2013-01-01 2013-01-01 false Designation of Officers of the National Archives and Records Administration To Act as Archivist of the United States Presidential Documents Other Presidential Documents Memorandum of May 21, 2012 Designation of Officers of the National Archives and Records Administration To Act as Archivist of...

  15. 21 CFR 21.31 - Records stored by the National Archives and Records Administration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Records stored by the National Archives and Records Administration. 21.31 Section 21.31 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... § 21.31 Records stored by the National Archives and Records Administration. (a) Food and...

  16. 21 CFR 21.31 - Records stored by the National Archives and Records Administration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Records stored by the National Archives and Records Administration. 21.31 Section 21.31 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... § 21.31 Records stored by the National Archives and Records Administration. (a) Food and...

  17. 21 CFR 21.31 - Records stored by the National Archives and Records Administration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Records stored by the National Archives and Records Administration. 21.31 Section 21.31 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... § 21.31 Records stored by the National Archives and Records Administration. (a) Food and...

  18. National Archives and Records Service Resources for the Study of Native Americans.

    ERIC Educational Resources Information Center

    Grim, Ronald E.

    Serving as an introduction to the various resources currently available in the National Archives and Records Service for geographic study of Native Americans, this paper describes the arrangement of National Archives records, identifies the major records pertaining to Native Americans, and presents an annotated bibliography of pertinent published…

  19. International glacier monitoring and data archiving, from a national perspective

    NASA Astrophysics Data System (ADS)

    Andreassen, Liss M.

    2016-04-01

    The Global Terrestrial Network for Glaciers (GTN-G) is a framework for internationally coordinated monitoring of glaciers and ice caps and run by three operational bodies: the World Glacier Monitoring Service (WGMS), the US National Snow and Ice Data Center (NSIDC), and the Global Land Ice Measurements from Space (GLIMS) initiative. In this talk, I will present recent progresses by GTN-G in efforts to store and provide extensive glaciological data to the community. I will also discuss some of the challenges in monitoring and data archiving, illustrated with examples from my own experiences as a data provider. Finally, I would like to discuss how we as a community could enrich and complete existing databases.

  20. The long hold: Storing data at the National Archives

    NASA Technical Reports Server (NTRS)

    Thibodeau, Kenneth

    1991-01-01

    A description of the information collection and storage needs of the National Archives and Records Administration (NARA) is presented. The unique situation of NARA is detailed. Two aspects which make the issue of obsolescence especially complex and costly are dealing with incoherent data and satisfying unknown and unknowable requirements. The data is incoherent because it comes from a wide range of independent sources, covers unrelated subjects, and is organized and encoded in ways that are not only not controlled but often unknown until received. NARA's mission to preserve and provide access to records with enduring value makes NARA, in effect, the agent of future generations. NARA's responsibility to the future places itself is a perpetual quandary of devotion to serving needs which are unknown.

  1. A Comparative Study of the Administration of the Government Documents Sections of the National Archives of the United States, the National Library of Canada, Selected American State Archives and Libraries.

    ERIC Educational Resources Information Center

    Freeman, Nola A.

    This report, written for a National Archives Staff training program, presents the results of a survey which sought information about the administration of the government documents sections of the National Library of Canada, the National Archives of the United States, and 12 selected American state archives and state libraries. The survey gathered…

  2. 36 CFR 1280.82 - How will NARA handle my request to use public areas in the National Archives Building?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... request to use public areas in the National Archives Building? 1280.82 Section 1280.82 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building,...

  3. 36 CFR 1235.18 - How do agencies transfer records to the National Archives of the United States?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... records to the National Archives of the United States? 1235.18 Section 1235.18 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL ARCHIVES OF THE UNITED STATES General Transfer Requirements § 1235.18 How do agencies...

  4. 36 CFR 1235.12 - When must agencies transfer records to the National Archives of the United States?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... records to the National Archives of the United States? 1235.12 Section 1235.12 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL ARCHIVES OF THE UNITED STATES General Transfer Requirements § 1235.12 When must agencies...

  5. 36 CFR 1280.76 - When are the public areas available for private events in the National Archives Building?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... available for private events in the National Archives Building? 1280.76 Section 1280.76 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building,...

  6. 36 CFR 1280.80 - How do I request to use NARA public areas in the National Archives Building?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... public areas in the National Archives Building? 1280.80 Section 1280.80 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building, Washington,...

  7. 36 CFR 1235.10 - What records do agencies transfer to the National Archives of the United States?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... transfer to the National Archives of the United States? 1235.10 Section 1235.10 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL ARCHIVES OF THE UNITED STATES General Transfer Requirements § 1235.10 What records do...

  8. 31 CFR 1.29 - Records transferred to Federal Records Center or National Archives of the United States.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Records Center or National Archives of the United States. 1.29 Section 1.29 Money and Finance: Treasury... Federal Records Center or National Archives of the United States. (a) Records transferred to the.... (b) Records transferred to the National Archives of the United States. (1) Records transferred...

  9. 36 CFR 1235.10 - What records do agencies transfer to the National Archives of the United States?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... transfer to the National Archives of the United States? 1235.10 Section 1235.10 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL ARCHIVES OF THE UNITED STATES General Transfer Requirements § 1235.10 What records do...

  10. 36 CFR 1280.80 - How do I request to use NARA public areas in the National Archives Building?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... public areas in the National Archives Building? 1280.80 Section 1280.80 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building, Washington,...

  11. 36 CFR 1280.76 - When are the public areas available for private events in the National Archives Building?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... available for private events in the National Archives Building? 1280.76 Section 1280.76 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building,...

  12. 36 CFR 1235.30 - How may records in the National Archives of the United States be used?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Archives of the United States be used? 1235.30 Section 1235.30 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL ARCHIVES OF THE UNITED STATES Administration of Transferred Records § 1235.30 How may records in...

  13. 36 CFR 1235.12 - When must agencies transfer records to the National Archives of the United States?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... records to the National Archives of the United States? 1235.12 Section 1235.12 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL ARCHIVES OF THE UNITED STATES General Transfer Requirements § 1235.12 When must agencies...

  14. 36 CFR 1280.82 - How will NARA handle my request to use public areas in the National Archives Building?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... request to use public areas in the National Archives Building? 1280.82 Section 1280.82 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building,...

  15. 31 CFR 1.29 - Records transferred to Federal Records Center or National Archives of the United States.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Records Center or National Archives of the United States. 1.29 Section 1.29 Money and Finance: Treasury... Federal Records Center or National Archives of the United States. (a) Records transferred to the.... (b) Records transferred to the National Archives of the United States. (1) Records transferred...

  16. 36 CFR 1235.18 - How do agencies transfer records to the National Archives of the United States?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... records to the National Archives of the United States? 1235.18 Section 1235.18 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL ARCHIVES OF THE UNITED STATES General Transfer Requirements § 1235.18 How do agencies...

  17. 36 CFR 1280.82 - How will NARA handle my request to use public areas in the National Archives Building?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... request to use public areas in the National Archives Building? 1280.82 Section 1280.82 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building,...

  18. 36 CFR 1280.82 - How will NARA handle my request to use public areas in the National Archives Building?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... request to use public areas in the National Archives Building? 1280.82 Section 1280.82 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building,...

  19. 36 CFR 1280.82 - How will NARA handle my request to use public areas in the National Archives Building?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... request to use public areas in the National Archives Building? 1280.82 Section 1280.82 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives Building,...

  20. Enriching Great Britain's National Landslide Database by searching newspaper archives

    NASA Astrophysics Data System (ADS)

    Taylor, Faith E.; Malamud, Bruce D.; Freeborough, Katy; Demeritt, David

    2015-11-01

    Our understanding of where landslide hazard and impact will be greatest is largely based on our knowledge of past events. Here, we present a method to supplement existing records of landslides in Great Britain by searching an electronic archive of regional newspapers. In Great Britain, the British Geological Survey (BGS) is responsible for updating and maintaining records of landslide events and their impacts in the National Landslide Database (NLD). The NLD contains records of more than 16,500 landslide events in Great Britain. Data sources for the NLD include field surveys, academic articles, grey literature, news, public reports and, since 2012, social media. We aim to supplement the richness of the NLD by (i) identifying additional landslide events, (ii) acting as an additional source of confirmation of events existing in the NLD and (iii) adding more detail to existing database entries. This is done by systematically searching the Nexis UK digital archive of 568 regional newspapers published in the UK. In this paper, we construct a robust Boolean search criterion by experimenting with landslide terminology for four training periods. We then apply this search to all articles published in 2006 and 2012. This resulted in the addition of 111 records of landslide events to the NLD over the 2 years investigated (2006 and 2012). We also find that we were able to obtain information about landslide impact for 60-90% of landslide events identified from newspaper articles. Spatial and temporal patterns of additional landslides identified from newspaper articles are broadly in line with those existing in the NLD, confirming that the NLD is a representative sample of landsliding in Great Britain. This method could now be applied to more time periods and/or other hazards to add richness to databases and thus improve our ability to forecast future events based on records of past events.

  1. 36 CFR 1280.14 - May I use the shuttle bus to travel to the National Archives at College Park or to the National...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false May I use the shuttle bus to travel to the National Archives at College Park or to the National Archives Building in Washington, DC? 1280.14 Section 1280.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND...

  2. 36 CFR 1280.14 - May I use the shuttle bus to travel to the National Archives at College Park or to the National...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false May I use the shuttle bus to travel to the National Archives at College Park or to the National Archives Building in Washington, DC? 1280.14 Section 1280.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND...

  3. 36 CFR 1280.14 - May I use the shuttle bus to travel to the National Archives at College Park or to the National...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true May I use the shuttle bus to travel to the National Archives at College Park or to the National Archives Building in Washington, DC? 1280.14 Section 1280.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND...

  4. 36 CFR 1280.14 - May I use the shuttle bus to travel to the National Archives at College Park or to the National...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false May I use the shuttle bus to travel to the National Archives at College Park or to the National Archives Building in Washington, DC? 1280.14 Section 1280.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND...

  5. 36 CFR 1280.14 - May I use the shuttle bus to travel to the National Archives at College Park or to the National...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false May I use the shuttle bus to travel to the National Archives at College Park or to the National Archives Building in Washington, DC? 1280.14 Section 1280.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND...

  6. Artifacts at the National Archives: A Summary of Past Practices, Present Uses, and Prospective Arrangements.

    ERIC Educational Resources Information Center

    Lash, Jeffrey N.

    This paper presents a summary of the policies and practices that have governed the accessioning and use of artifacts in the National Archives chiefly over the last decade, and it offers recommendations for the prospective relocation and utilization of artifacts at Archives II. The report is organized around three major headings: a treatment of the…

  7. EAC and the Development of National and European Gateways to Archives

    ERIC Educational Resources Information Center

    Ottosson, Per-Gunnar

    2005-01-01

    In the development of gateways to archives there are two different approaches, one focusing on the descriptions of the material and the other on the creators. Search and retrieval with precision and quality require controlled access points and name authority control. National registries of private archives have a long tradition in implementing the…

  8. Guidelines for the Preparation of General Guides to National Archives: A RAMP Study.

    ERIC Educational Resources Information Center

    Hildesheimer, Francoise

    Based on a comparative study of guides from the Bahamas, Barbados, France, Italy, the Netherlands, Rhodesia, Spain, the United Kingdom, the United States, West Germany, and Zambia, this handbook provides guidelines for the organization and content of a general guide to archives, particularly national archives. It is noted that the handbook is…

  9. Photographic Plate Archive of Astronomical Observatory of Ivan Franko National University of Lviv

    NASA Astrophysics Data System (ADS)

    Virun, N.; Pakuliak, L.; Kazantseva, L.

    2012-05-01

    The project of Ukrainian Virtual Observatory is based on the digitization of photographic plate archives, collected during more than 100 years, which together with CCD archieves are expected to form the Joint Digital Archive. The paper presents the description of archieves the historical photographical collections of astronomical observatories of Kyiv and Lviv national universities. The application of flatbed scanners for plate digitization is discussed.

  10. In Vivo Radiobiological Characterization of Proton Beam at the National Cancer Center in Korea: Effect of the Chk2 Mutation

    SciTech Connect

    Kim, Sang Soo; Choo, Dong Wan; Shin, Dongho; Baek, Hye Jung; Kim, Tae Hyun; Motoyama, Noboru; De Coster, Blanche M.; Gueulette, John; Furusawa, Yoshiya; Ando, Koichi; Cho, Kwan Ho

    2011-02-01

    Purpose: The relative biological effectiveness (RBE) in the presence or absence of CHK2 was estimated at the Korean National Cancer Center Proton Therapy Center (NCCPTC). Methods and Materials: The proton beam was fixed at 210 MeV with 6-cm spread-out Bragg peaks (SOBPs) because this is expected to be the most frequently used clinical setting. X-rays were obtained using a 6-MV conventional linear accelerator. The RBE was estimated from the survival of jejunal crypt in C3H/He and Chk2{sup -/-} mice. Results: The estimated RBEs of the NCCPTC at the middle of the SOBP were 1.10 and 1.05 in the presence and absence of CHK2, respectively. The doses that reduced the number of regenerated crypt per jejunal circumference to 20 (D{sub 20}) in C3H/He mice were 14.8 Gy (95% confidence interval [CI], 13.7-15.9) for X-rays and 13.5 Gy (95% CI, 14.5-15.5) for protons. By contrast, the doses of D{sub 20} in Chk2{sup -/-} mice were 15.7 Gy (95% CI, 15.0-16.4) and 14.9 Gy (95% CI, 14.0-15.8) for X-rays and protons, respectively. Conclusions: The RBE of the NCCPTC is clearly within the range of RBEs determined at other facilities and is consistent with the generic RBE value of 1.10 for 150- to 250-MeV beams. The mutation of Chk2 gave rise to radioresistance but exhibited similar RBE.

  11. Joint bone radiobiology workshop

    SciTech Connect

    Tomich, P.A.

    1991-01-01

    The Joint Bone Radiobiology Workshop was held on July 12--13, 1991 in Toronto, Canada. This document contains the papers presented at the meeting. The five sections were: Dose-effects, Endogenous Cofactors, Tumorigenesis, New Methods and Medical Implications. The papers covered risk assessment, tissue distribution of radionuclides, lifetime studies, biological half-lifes, the influence of age at time of exposure, tumor induction by different radionuclides, microscopic localization of radionuclides, and nuclear medicine issues including tissue distribution in the skeleton and bone marrow transplantation. (MHB)

  12. Expert Systems Technology and Its Implication for Archives. National Archives Technical Information Paper No. 9.

    ERIC Educational Resources Information Center

    Michelson, Avra

    This report introduces archivists to the potential of expert systems for improving archives administration and alerts them to ways in which they can expect intelligent technologies to impact federal record-keeping systems and scholarly research methods. The report introduces the topic by describing expert systems used in three Fortune 500…

  13. Non-extensive radiobiology

    SciTech Connect

    Sotolongo-Grau, O.; Rodriguez-Perez, D.; Antoranz, J. C.; Sotolongo-Costa, O.

    2011-03-14

    The expression of survival factors for radiation damaged cells is based on probabilistic assumptions and experimentally fitted for each tumor, radiation and conditions. Here we show how the simplest of these radiobiological models can be derived from the maximum entropy principle of the classical Boltzmann-Gibbs expression. We extend this derivation using the Tsallis entropy and a cutoff hypothesis, motivated by clinical observations. A generalization of the exponential, the logarithm and the product to a non-extensive framework, provides a simple formula for the survival fraction corresponding to the application of several radiation doses on a living tissue. The obtained expression shows a remarkable agreement with the experimental data found in the literature, also providing a new interpretation of some of the parameters introduced anew. It is also shown how the presented formalism may have direct application in radiotherapy treatment optimization through the definition of the potential effect difference, simply calculated between the tumour and the surrounding tissue.

  14. CRC handbook of radiobiology

    SciTech Connect

    Prasad, K.N.

    1984-01-01

    The author presents Development of Radiobiology. A Review. Basic Cell Biology. Physics of Radiation Biology. Cellular Radiation Damage. Modifications of Cellular Radiation Damage. Repair of Radiation Damage. Molecular Radiation Biology. Radiation Syndromes and their Modifications. Radiation Damage of Skin and Mucous Membrane. Radiation Damage of Nervous Tissue. Radiation Damage of Reproductive Organs. Radiation Damage of Other Organ Systems. Radiation Immunology. Background, Medical and Commercial Sources. Radiation Injuries to Human Fetuses. Radiation-Induced Genetic Damage. Radiation Carcinogenesis: Tissue Culture Model. Radiation Carcinogenesis: Animal Model. Radiation Carcinogenesis: Human Model. Radiation Carcinogenesis: Secondary Neoplasms. After Therapy of Tumors. Other Late Effects: Aging, Cataract, Aplastic Anemia. Maximum Permissible Dose (MPD). Radiation Response of Human Tumor. Radioisotopes in Biology and Medicine.

  15. Non-extensive radiobiology

    NASA Astrophysics Data System (ADS)

    Sotolongo-Grau, O.; Rodriguez-Perez, D.; Antoranz, J. C.; Sotolongo-Costa, O.

    2011-03-01

    The expression of survival factors for radiation damaged cells is based on probabilistic assumptions and experimentally fitted for each tumor, radiation and conditions. Here we show how the simplest of these radiobiological models can be derived from the maximum entropy principle of the classical Boltzmann-Gibbs expression. We extend this derivation using the Tsallis entropy and a cutoff hypothesis, motivated by clinical observations. A generalization of the exponential, the logarithm and the product to a non-extensive framework, provides a simple formula for the survival fraction corresponding to the application of several radiation doses on a living tissue. The obtained expression shows a remarkable agreement with the experimental data found in the literature, also providing a new interpretation of some of the parameters introduced anew. It is also shown how the presented formalism may have direct application in radiotherapy treatment optimization through the definition of the potential effect difference, simply calculated between the tumour and the surrounding tissue.

  16. 36 CFR 1280.60 - Where do I enter the National Archives Building in Washington, DC?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Where do I enter the National Archives Building in Washington, DC? 1280.60 Section 1280.60 Parks, Forests, and Public Property NATIONAL... for Using NARA Facilities in the Washington, DC, Area? § 1280.60 Where do I enter the...

  17. Role and Justification of Web Archiving by National Libraries: A Questionnaire Survey

    ERIC Educational Resources Information Center

    Shiozaki, Ryo; Eisenschitz, Tamara

    2009-01-01

    This paper reports on a questionnaire survey of 16 national libraries designed to clarify how national libraries attempt to justify their web archiving activities. Results indicate they envisage that a) the benefits brought about by their initiatives are greater than the overall costs, b) the costs imposed on libraries are greater than the costs…

  18. The Importance of Dosimetry Standardization in Radiobiology

    PubMed Central

    Desrosiers, Marc; DeWerd, Larry; Deye, James; Lindsay, Patricia; Murphy, Mark K; Mitch, Michael; Macchiarini, Francesca; Stojadinovic, Strahinja; Stone, Helen

    2013-01-01

    Radiation dose is central to much of radiobiological research. Precision and accuracy of dose measurements and reporting of the measurement details should be sufficient to allow the work to be interpreted and repeated and to allow valid comparisons to be made, both in the same laboratory and by other laboratories. Despite this, a careful reading of published manuscripts suggests that measurement and reporting of radiation dosimetry and setup for radiobiology research is frequently inadequate, thus undermining the reliability and reproducibility of the findings. To address these problems and propose a course of action, the National Cancer Institute (NCI), the National Institute of Allergy and Infectious Diseases (NIAID), and the National Institute of Standards and Technology (NIST) brought together representatives of the radiobiology and radiation physics communities in a workshop in September, 2011. The workshop participants arrived at a number of specific recommendations as enumerated in this paper and they expressed the desirability of creating dosimetry standard operating procedures (SOPs) for cell culture and for small and large animal experiments. It was also felt that these SOPs would be most useful if they are made widely available through mechanism(s) such as the web, where they can provide guidance to both radiobiologists and radiation physicists, be cited in publications, and be updated as the field and needs evolve. Other broad areas covered were the need for continuing education through tutorials at national conferences, and for journals to establish standards for reporting dosimetry. This workshop did not address issues of dosimetry for studies involving radiation focused at the sub-cellular level, internally-administered radionuclides, biodosimetry based on biological markers of radiation exposure, or dose reconstruction for epidemiological studies. PMID:26401441

  19. 36 CFR 1280.86 - When are the public areas available for events in the National Archives at College Park?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false When are the public areas available for events in the National Archives at College Park? 1280.86 Section 1280.86 Parks, Forests, and... Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park,...

  20. 36 CFR 1280.86 - When are the public areas available for events in the National Archives at College Park?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false When are the public areas available for events in the National Archives at College Park? 1280.86 Section 1280.86 Parks, Forests, and... Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park,...

  1. 36 CFR 1280.86 - When are the public areas available for events in the National Archives at College Park?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false When are the public areas available for events in the National Archives at College Park? 1280.86 Section 1280.86 Parks, Forests, and... Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park,...

  2. 36 CFR 1280.86 - When are the public areas available for events in the National Archives at College Park?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false When are the public areas available for events in the National Archives at College Park? 1280.86 Section 1280.86 Parks, Forests, and... Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park,...

  3. 36 CFR 1280.86 - When are the public areas available for events in the National Archives at College Park?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true When are the public areas available for events in the National Archives at College Park? 1280.86 Section 1280.86 Parks, Forests, and... Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park,...

  4. "The Glory and Romance of Our History Are Here Preserved." An Introduction to the Records of the National Archives.

    ERIC Educational Resources Information Center

    National Archives and Records Administration, Washington, DC. Office of Public Programs.

    This publication is intended for teachers bringing a class to visit the National Archives in Washington, D.C., for a workshop on primary documents. The National Archives serves as the repository for all federal records of enduring value. Primary sources are vital teaching tools because they actively engage the student's imagination so that he or…

  5. Radiobiological studies using gamma and x rays.

    SciTech Connect

    Potter, Charles Augustus; Longley, Susan W.; Scott, Bobby R.; Lin, Yong; Wilder, Julie; Hutt, Julie A.; Padilla, Mabel T.; Gott, Katherine M.

    2013-02-01

    There are approximately 500 self-shielded research irradiators used in various facilities throughout the U.S. These facilities use radioactive sources containing either 137Cs or 60Co for a variety of biological investigations. A report from the National Academy of Sciences[1] described the issues with security of particular radiation sources and the desire for their replacement. The participants in this effort prepared two peer-reviewed publications to document the results of radiobiological studies performed using photons from 320-kV x rays and 137Cs on cell cultures and mice. The effectiveness of X rays was shown to vary with cell type.

  6. Audiovisual Records in the National Archives Relating to Black History. Preliminary Draft.

    ERIC Educational Resources Information Center

    Waffen, Leslie; And Others

    A representative selection of the National Archives and Records Services' audiovisual collection relating to black history is presented. The intention is not to provide an exhaustive survey, but rather to indicate the breadth and scope of materials available for study and to suggest areas for concentrated research. The materials include sound…

  7. Planning National Infrastructures for Documentation, Libraries and Archives; Outline of a General Policy.

    ERIC Educational Resources Information Center

    D'Olier, J. H.; Delmas, B.

    Designed for governmental planners, documentalists, librarians, and archivists, these two United Nations studies examine integration of the planning of libraries and archives services with the planning of economic and social development. In Study 1, the planning of documentation centers and libraries is investigated. An appendix includes survey…

  8. Building a National Strategy for Digital Preservation: Issues in Digital Media Archiving.

    ERIC Educational Resources Information Center

    Council on Library and Information Resources, Washington, DC.

    The United States Congress in December 2000 appropriated funds to the Library of Congress (LC) to spearhead an effort to develop a national strategy for the preservation of digital information. LC staff scheduled a series of conversations with representatives from the technology, business, entertainment, academic, legal, archival, and library…

  9. Guide to Records in the National Archives of the United States Relating to American Indians.

    ERIC Educational Resources Information Center

    Hill, Edward E., Comp.

    To be used by researchers, this specialized supplement to the general "Guide to the National Archives of the United States" (1974) employs an historical approach to describe pre-federal, federal, and non-federal holdings relating to American Indians. Included are Continental Congress and Revolutionary War records. Records of the Bureau of Indian…

  10. The radiobiology of hypofractionation.

    PubMed

    Nahum, Alan E

    2015-05-01

    If the α/β ratio is high (e.g. 10 Gy) for tumour clonogen killing, but low (e.g. 3 Gy) for late normal tissue complications, then delivering external beam radiotherapy in a large number (20-30) of small (≈2 Gy) dose fractions should yield the highest 'therapeutic ratio'; this is demonstrated via the linear-quadratic model of cell killing. However, this 'conventional wisdom' is increasingly being challenged, partly by the success of stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy (SABR) extreme hypofractionation regimens of three to five large fractions for early stage non-small cell lung cancer and partly by indications that for certain tumours (prostate, breast) the α/β ratio may be of the same order or even lower than that characterising late complications. It is shown how highly conformal dose delivery combined with quasi-parallel normal tissue behaviour (n close to 1) enables 'safe' hypofractionation; this can be predicted by the (α/β)eff concept for normal tissues. Recent analyses of the clinical outcomes of non-small cell lung cancer radiotherapy covering 'conventional' hyper- to extreme hypofractionation (stereotactic ablative radiotherapy) regimens are consistent with linear-quadratic radiobiology, even at the largest fraction sizes, despite there being theoretical reasons to expect 'LQ violation' above a certain dose. Impairment of re-oxygenation between fractions and the very high (α/β) for hypoxic cells can complicate the picture regarding the analysis of clinical outcomes; it has also been suggested that vascular damage may play a role for very large dose fractions. Finally, the link between high values of (α/β)eff and normal-tissue sparing for quasi-parallel normal tissues, thereby favouring hypofractionation, may be particularly important for proton therapy, but more generally, improved conformality, achieved by whatever technique, can be translated into individualisation of both prescription dose and fraction

  11. The preservation of LANDSAT data by the National Land Remote Sensing Archive

    NASA Technical Reports Server (NTRS)

    Boyd, John E.

    1992-01-01

    Digital data, acquired by the National Landsat Remote Sensing Program, document nearly two decades of global agricultural, environmental, and sociological change. The data were widely applied and continue to be essential to a variety of geologic, hydrologic, agronomic, and strategic programs and studies by governmental, academic, and commercial researchers. Landsat data were acquired by five observatories that use primarily two digital sensor systems. The Multispectral Scanner (MSS) was onboard all five Landsats, which have orbited over 19 years; the higher resolution Thematic Mapper (TM) sensor acquired data for the last 9 years on Landsats 4 and 5 only. The National Land Remote Sensing Archive preserves the 800,000 scenes, which total more than 60 terabytes of data, on master tapes that are steadily deteriorating. Data are stored at two terabytes of data, on master tapes that are steadily deteriorating. Data are stored at two locations (Sioux Falls, South Dakota and Landover, Maryland), in three archive formats. The U.S. Geological Survey's EROS Data Center has initiated a project to consolidate and convert, over the next 4 years, two of the archive formats from antiquated instrumentation tape to rotary-recorded cassette magnetic tape. The third archive format, consisting of 300,000 scenes of MSS data acquired from 1972 through 1978, will not be converted because of budgetary constraints. This data preservation project augments EDC's experience in data archiving and information management, expertise that is critical to EDC's role as a Distributed Active Archive Center for the Earth Observing System, a new and much larger national earth science program.

  12. 36 CFR 1280.89 - How will NARA handle my request to use public areas in the National Archives at College Park?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... request to use public areas in the National Archives at College Park? 1280.89 Section 1280.89 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives...

  13. 36 CFR 1254.86 - May I use a personal paper-to-paper copier at the National Archives at College Park?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-paper copier at the National Archives at College Park? 1254.86 Section 1254.86 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS... § 1254.86 May I use a personal paper-to-paper copier at the National Archives at College Park? (a) At...

  14. 36 CFR 1280.89 - How will NARA handle my request to use public areas in the National Archives at College Park?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... request to use public areas in the National Archives at College Park? 1280.89 Section 1280.89 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives...

  15. 36 CFR 1254.86 - May I use a personal paper-to-paper copier at the National Archives at College Park?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-paper copier at the National Archives at College Park? 1254.86 Section 1254.86 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS... § 1254.86 May I use a personal paper-to-paper copier at the National Archives at College Park? (a) At...

  16. 36 CFR 1280.89 - How will NARA handle my request to use public areas in the National Archives at College Park?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... request to use public areas in the National Archives at College Park? 1280.89 Section 1280.89 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives...

  17. 36 CFR 1254.86 - May I use a personal paper-to-paper copier at the National Archives at College Park?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-paper copier at the National Archives at College Park? 1254.86 Section 1254.86 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS... § 1254.86 May I use a personal paper-to-paper copier at the National Archives at College Park? (a) At...

  18. Radiobiology of pions at LAMPF.

    PubMed

    Raju, M R; Tokita, N

    1982-12-01

    Recent radiobiology data for pion beams used in therapy are presented. The biological systems used were cultured cells suspended in gelatin and intestinal crypt assay. The importance of fast neutrons from pion stars in large treatment volumes is discussed. The data for compensating the depth dose distribution to produce uniform cell killing across the peak region are presented. The changes in biological effectiveness with peak width for pion beams (unlike heavy ions) are small because of fast neutron contribution from pion stars. The need for innovative radiobiology programs to guide high-LET radiotherapy is discussed. PMID:7161165

  19. Radiobiological research at JINR's accelerators

    NASA Astrophysics Data System (ADS)

    Krasavin, E. A.

    2016-04-01

    The half-a-century development of radiobiological studies at the Joint Institute for Nuclear Research (JINR) is reviewed on a stage-by-stage basis. With the use of the institute's accelerators, some key aspects of radiation biology have been settled, including the relative biological effectiveness (RBE) of various types of ionizing radiation with different physical characteristics; radiation-induced mutagenesis mechanisms, and the formation and repair of genetic structure damage. Practical space radiobiology problems that can be solved using high-energy charged particles are discussed.

  20. UK National Data Centre archive of seismic recordings of (presumed) underground nuclear tests 1964-1996

    NASA Astrophysics Data System (ADS)

    Young, John; Peacock, Sheila

    2016-04-01

    The year 1996 has particular significance for forensic seismologists. This was the year when the Comprehensive Test Ban Treaty (CTBT) was signed in September at the United Nations, setting an international norm against nuclear testing. Blacknest, as a long time seismic centre for research into detecting and identifying underground explosions using seismology, provided significant technical advice during the CTBT negotiations. Since 1962 seismic recordings of both presumed nuclear explosions and earthquakes from the four seismometer arrays Eskdalemuir, Scotland (EKA), Yellowknife, Canada (YKA), Gauribidanur, India (GBA), and Warramunga, Australia (WRA) have been copied, digitised, and saved. There was a possibility this archive would be lost. It was decided to process the records and catalogue them for distribution to other groups and institutions. This work continues at Blacknest but the archive is no longer under threat. In addition much of the archive of analogue tape recordings has been re-digitised with modern equipment, allowing sampling rates of 100 rather than 20 Hz.

  1. Archiving oceanographic data at NOAA's National Oceanographic Data Center: A use-case approach

    NASA Astrophysics Data System (ADS)

    Biddle, M.; Arzayus, K. M.; Collins, D.; Paver, C. R.; Rutz, S. B.

    2012-12-01

    Current data holdings at the National Oceanographic Data Center (NODC) include physical, biological and chemical measurements of in situ oceanographic variables, satellite data products, and ocean model simulations. NODC acquires data from a wide variety of partners that span academia, government (including state and federal sources), private industry, and non-profit organizations. NODC provides access to these diverse data collections for both current and future use, to ensure that data consumers have the ability to monitor present and past environmental conditions. Using a flexible archival infrastructure enables NODC to archive almost any type of file format. NODC is deploying web services built upon OPeNDAP, THREDDS, Geoportal, and other standard technologies to enable data integration and application-ready data for a broad spectrum of data consumers. To maximize use of these web services, NODC is working with the oceanographic community to utilize standard formats, such as netCDF, for representing data. This poster outlines use cases which describe how a data provider can 1) establish a relationship with NODC, 2) communicate and document requirements for archiving data, 3) fulfill funding agency data management requirements, and 4) implement an automated process for archiving standard recurring data sets, where applicable. As a result of this interaction, NODC can provide valuable feedback to data providers to improve the quality of their metadata and/or data, provide access to archived data via multiple services, and facilitate data use in various data products to inform scientists and the public about the state of the ocean.

  2. Advocacy for the Archives and History Office of the SLAC National Accelerator Laboratory: Stages and Methods

    SciTech Connect

    Deken, Jean Marie; /SLAC

    2009-06-19

    Advocating for the good of the SLAC Archives and History Office (AHO) has not been a one-time affair, nor has it been a one-method procedure. It has required taking time to ascertain the current and perhaps predict the future climate of the Laboratory, and it has required developing and implementing a portfolio of approaches to the goal of building a stronger archive program by strengthening and appropriately expanding its resources. Among the successful tools in the AHO advocacy portfolio, the Archives Program Review Committee has been the most visible. The Committee and the role it serves as well as other formal and informal advocacy efforts are the focus of this case study My remarks today will begin with a brief introduction to advocacy and outreach as I understand them, and with a description of the Archives and History Office's efforts to understand and work within the corporate culture of the SLAC National Accelerator Laboratory. I will then share with you some of the tools we have employed to advocate for the Archives and History Office programs and activities; and finally, I will talk about how well - or badly - those tools have served us over the past decade.

  3. 36 CFR 1280.74 - What spaces in the National Archives Building are available for use by non-NARA groups and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Archives Building are available for use by non-NARA groups and organizations? 1280.74 Section 1280.74 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives...

  4. The National Petroleum Reserve-Alaska (NPRA) data archive

    USGS Publications Warehouse

    Bird, K.J.

    2001-01-01

    The area currently known as the National Petroleum ReserveAlaska was originally designated in 1923 as Naval Petroleum Reserve No. 4 (NPR4). It was one of four U.S. regions thought to contain significant amounts of oil that were to be reserved for national crises. Geographic and geologic knowledge of the NPR4 was only superficial in 1923. Earlier exploration, however, had shown that the region contained the ingredients necessary for oil accumulations to exist: source rocks, reservoir rocks, and geologic structures that could trap petroleum. Oil seeps on the coast and the size of the area (some 37,000 square miles, about the size of Indiana) reinforced the notion that significant quantities of petroleum were present.

  5. 77 FR 7184 - Public Availability of the National Archives and Records Administration FY 2011 Service Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ...In accordance with Section 743 of Division C of the Consolidated Appropriations Act of 2010 (Pub. L. 111-117), the National Archives and Records Administration (NARA) is publishing this notice to advise the public of the availability of its FY 2011 Service Contract inventory. This inventory provides information on service contract actions over $25,000 that were made in FY 2011. The information......

  6. BNL ACCELERATOR-BASED RADIOBIOLOGY FACILITIES

    SciTech Connect

    LOWENSTEIN,D.I.

    2000-05-28

    For the past several years, the Alternating Gradient Synchrotron (AGS) at Brookhaven National Laboratory (USA) has provided ions of iron, silicon and gold, at energies from 600 MeV/nucleon to 10 GeV/nucleon, for the US National Aeronautics and Space Administration (NASA) radiobiology research program. NASA has recently funded the construction of a new dedicated ion facility, the Booster Applications Facility (BAF). The Booster synchrotron will supply ion beams ranging from protons to gold, in an energy range from 40--3,000 MeV/nucleon with maximum beam intensities of 10{sup 10} to 10{sup 11} ions per pulse. The BAF Project is described and the future AGS and BAF operation plans are presented.

  7. 36 CFR 1280.78 - Does NARA charge fees for the use of public areas in the National Archives Building?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... NARA will either exercise this authority directly, or, for activities co-sponsored with the Foundation for the National Archives, as part of your group's arrangements with the Foundation. (b) We...

  8. 36 CFR 1280.78 - Does NARA charge fees for the use of public areas in the National Archives Building?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... NARA will either exercise this authority directly, or, for activities co-sponsored with the Foundation for the National Archives, as part of your group's arrangements with the Foundation. (b) We...

  9. 36 CFR 1280.78 - Does NARA charge fees for the use of public areas in the National Archives Building?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... NARA will either exercise this authority directly, or, for activities co-sponsored with the Foundation for the National Archives, as part of your group's arrangements with the Foundation. (b) We...

  10. 36 CFR 1280.78 - Does NARA charge fees for the use of public areas in the National Archives Building?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... NARA will either exercise this authority directly, or, for activities co-sponsored with the Foundation for the National Archives, as part of your group's arrangements with the Foundation. (b) We...

  11. 36 CFR 1280.78 - Does NARA charge fees for the use of public areas in the National Archives Building?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... NARA will either exercise this authority directly, or, for activities co-sponsored with the Foundation for the National Archives, as part of your group's arrangements with the Foundation. (b) We...

  12. 36 CFR 1235.46 - What electronic media may be used for transferring records to the National Archives of the United...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to the National Archives of the United States. (See 36 CFR 1236.28 for the requirements governing the... records to an archival medium. (3) If permanent electronic records are stored on both CD-ROM (or DVD)...

  13. Digital information management: a progress report on the National Digital Mammography Archive

    NASA Astrophysics Data System (ADS)

    Beckerman, Barbara G.; Schnall, Mitchell D.

    2002-05-01

    Digital mammography creates very large images, which require new approaches to storage, retrieval, management, and security. The National Digital Mammography Archive (NDMA) project, funded by the National Library of Medicine (NLM), is developing a limited testbed that demonstrates the feasibility of a national breast imaging archive, with access to prior exams; patient information; computer aids for image processing, teaching, and testing tools; and security components to ensure confidentiality of patient information. There will be significant benefits to patients and clinicians in terms of accessible data with which to make a diagnosis and to researchers performing studies on breast cancer. Mammography was chosen for the project, because standards were already available for digital images, report formats, and structures. New standards have been created for communications protocols between devices, front- end portal and archive. NDMA is a distributed computing concept that provides for sharing and access across corporate entities. Privacy, auditing, and patient consent are all integrated into the system. Five sites, Universities of Pennsylvania, Chicago, North Carolina and Toronto, and BWXT Y12, are connected through high-speed networks to demonstrate functionality. We will review progress, including technical challenges, innovative research and development activities, standards and protocols being implemented, and potential benefits to healthcare systems.

  14. Building digital archives by the National Diet Library : Toward knowledge sharing

    NASA Astrophysics Data System (ADS)

    Nakayama, Masaki

    This article shows the current situation of construction of the National Diet Library (NDL)'s digital archive and the direction of activities for “creating and reproducing new knowledge” which “knowledge sharing” aims at. The NDL, as a deposit library has a responsibility to acquire and preserve not only paper materials but also digital contents, and needs to make them accessible anytime and anywhere. The NDL acquires and preserves digital contents to a maximum extent to build the NDL digital archive. However, it is impossible to collect all of them, so the NDL plans to accumulate all knowledge in cooperation with other institutions to build distributed digital archives. The NDL plays a data provider role to navigate all the distributed digital archival information and make it available as semantically-related knowledge to build “NDL Search”. The NDL will make it possible to create new knowledge reusing the existing information as knowledge to build up the knowledge infrastructure.

  15. Implementation of National Satellite Based Data Archive (NASABADA) in Turkey

    NASA Astrophysics Data System (ADS)

    Gökdemir, Orhan; Beşer, Özgür; Sürer, Serdar

    2010-05-01

    NASABADA is a unique platform aiming to develop main geographical information system and remote sensing layers that are often used in areas such as: agriculture, forest, climate, hydrology, transportation, meteorology, and energy. Its establishment has started at the second half of the year 2009 in Turkey by Beray Engineering Company, and focused on especially Turkey domain as an individual study area. In general, examples of the satellite-based data-oriented production are usually on global scale and and focuses on a specific satellite. However, the products in NASABADA are consistent with Turkey's geographical conditions, and they are supported by ground information and a time series evaluation as well. Moreover, while developing those algorithms priority is using the national resources and providing a know-how for national information infrastructure. Using different features of satellite data and blending them with ground data to develop and provide the results to the end users of these products is one of the main goals of NASABADA Project. In the first stage of NASABADA, development of 7 products is planned, but the number of products is aimed to be around 20 in the future. The explanation of the pioneering 7 products which their preliminary versions would be published in the near future are as follows: albedo, snow cover, snow water equivalent, cloud, surface temperature, vegetation indices, and daily sun radiation maps. Unique architectural design, algorithms including fuzzy logic and ANN methods have been used for image processing and automatic analysis of large amounts of data on a high-tec file and web servers hardware infrastructure. The final aim of NASABADA is developing a data infrastructure for optimal access to those huge amounts of observational data by end users with tools available to make online processing of data and only gathering required images other than raw data. We discuss the development of the NASABADA data infrastructure, its current

  16. Twenty years of Landsat data accessible through the national satellite land remote sensing data archive

    USGS Publications Warehouse

    Larsen, Dana M.

    1993-01-01

    The EROS Data Center has managed to National Satellite Land Remote Sensing Data Archive's (NSLRSDA) Landsat data since 1972. The NSLRSDA includes Landsat MSS data from 1972 through 1991 and T M data from 1982 through 1993. In response to many requests from multi-disciplined users for an enhanced insight into the availability and volume of Landsat data over specific worldwide land areas, numerous world plots and corresponding statical overviews have been prepared. These presentations include information related to image quality, cloud cover, various types of data overage (i.e. regions, countries, path, rows), acquisition station coverage areas, various archive media formats (i.e. wide band video tapes, computer compatible tapes, high density tapes, etc.) and acquisition time periods (i.e. years, seasons). Plans are to publish this information in a paper sample booklet at the Pecora 12 Symposium, in a USGS circular and on a Landsat CD-ROM; the data will be also be incorporated into GLIS.

  17. 36 CFR 1280.74 - What spaces in the National Archives Building are available for use by non-NARA groups and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false What spaces in the National..., Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE OF NARA FACILITIES What Rules Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives...

  18. Federal Agency and Federal Library Reports. Library of Congress; Center for the Book; Federal Library and Information Center Committee; National Commission on Libraries and Information Science; National Agricultural Library; National Library of Medicine;United States Government Printing Office; National Technical Information Service; National Archives and Records Administration; National Center for Education Statistics Library Statistics Program; National Library of Education; Educational Resources Information Center.

    ERIC Educational Resources Information Center

    Fischer, Audrey; Cole, John Y.; Tarr, Susan M.; Vlach, Rosalie B.; Carey, Len; Mehnert, Robert; Sherman, Andrew M.; Davis, Linda; Vecchiarelli, Marion H.; Chute, Adrienne; Dunn, Christina

    2002-01-01

    Includes reports from Library of Congress, Center for the Book, Federal Library and Information Center Committee, National Commission on Libraries and Information Science, National Agricultural Library, National Library of Medicine, Government Printing Office, National Technical Information Service, National Archives and Records Administration,…

  19. 36 CFR 1256.96 - What provisions apply to the transfer of USIA audiovisual records to the National Archives of the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...? The provisions of 44 U.S.C. 2107 and 36 CFR part 1228 apply to the transfer of USIA audiovisual... transfer of USIA audiovisual records to the National Archives of the United States? 1256.96 Section 1256.96 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY...

  20. 36 CFR 1256.96 - What provisions apply to the transfer of USIA audiovisual records to the National Archives of the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...? The provisions of 44 U.S.C. 2107 and 36 CFR part 1228 apply to the transfer of USIA audiovisual... transfer of USIA audiovisual records to the National Archives of the United States? 1256.96 Section 1256.96 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY...

  1. 36 CFR 1280.87 - Does NARA charge fees for the use of public areas in the National Archives at College Park?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Does NARA charge fees for the use of public areas in the National Archives at College Park? 1280.87 Section 1280.87 Parks, Forests... College Park, Md § 1280.87 Does NARA charge fees for the use of public areas in the National Archives...

  2. 36 CFR 1280.88 - How do I request to use NARA public areas in the National Archives at College Park?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false How do I request to use NARA public areas in the National Archives at College Park? 1280.88 Section 1280.88 Parks, Forests, and Public... Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park, Md §...

  3. 36 CFR 1280.88 - How do I request to use NARA public areas in the National Archives at College Park?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false How do I request to use NARA public areas in the National Archives at College Park? 1280.88 Section 1280.88 Parks, Forests, and Public... Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park, Md §...

  4. 36 CFR 1280.85 - What space in the National Archives at College Park is available for use by non-NARA groups and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false What space in the National Archives at College Park is available for use by non-NARA groups and organizations? 1280.85 Section 1280.85 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE...

  5. 36 CFR 1280.87 - Does NARA charge fees for the use of public areas in the National Archives at College Park?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Does NARA charge fees for the use of public areas in the National Archives at College Park? 1280.87 Section 1280.87 Parks, Forests... College Park, Md § 1280.87 Does NARA charge fees for the use of public areas in the National Archives...

  6. 36 CFR 1280.89 - How will NARA handle my request to use public areas in the National Archives at College Park?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false How will NARA handle my request to use public areas in the National Archives at College Park? 1280.89 Section 1280.89 Parks... College Park, Md § 1280.89 How will NARA handle my request to use public areas in the National Archives...

  7. 36 CFR 1280.87 - Does NARA charge fees for the use of public areas in the National Archives at College Park?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Does NARA charge fees for the use of public areas in the National Archives at College Park? 1280.87 Section 1280.87 Parks, Forests... College Park, Md § 1280.87 Does NARA charge fees for the use of public areas in the National Archives...

  8. 36 CFR 1280.89 - How will NARA handle my request to use public areas in the National Archives at College Park?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false How will NARA handle my request to use public areas in the National Archives at College Park? 1280.89 Section 1280.89 Parks... College Park, Md § 1280.89 How will NARA handle my request to use public areas in the National Archives...

  9. 36 CFR 1280.88 - How do I request to use NARA public areas in the National Archives at College Park?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true How do I request to use NARA public areas in the National Archives at College Park? 1280.88 Section 1280.88 Parks, Forests, and Public... Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park, Md §...

  10. 36 CFR 1280.88 - How do I request to use NARA public areas in the National Archives at College Park?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false How do I request to use NARA public areas in the National Archives at College Park? 1280.88 Section 1280.88 Parks, Forests, and Public... Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park, Md §...

  11. 36 CFR 1280.87 - Does NARA charge fees for the use of public areas in the National Archives at College Park?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Does NARA charge fees for the use of public areas in the National Archives at College Park? 1280.87 Section 1280.87 Parks, Forests... College Park, Md § 1280.87 Does NARA charge fees for the use of public areas in the National Archives...

  12. 36 CFR 1280.85 - What space in the National Archives at College Park is available for use by non-NARA groups and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false What space in the National Archives at College Park is available for use by non-NARA groups and organizations? 1280.85 Section 1280.85 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE...

  13. 36 CFR 1280.88 - How do I request to use NARA public areas in the National Archives at College Park?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false How do I request to use NARA public areas in the National Archives at College Park? 1280.88 Section 1280.88 Parks, Forests, and Public... Apply to Use NARA Public Areas in the Washington, DC, Area? National Archives at College Park, Md §...

  14. 36 CFR 1280.85 - What space in the National Archives at College Park is available for use by non-NARA groups and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true What space in the National Archives at College Park is available for use by non-NARA groups and organizations? 1280.85 Section 1280.85 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE...

  15. 36 CFR 1280.85 - What space in the National Archives at College Park is available for use by non-NARA groups and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false What space in the National Archives at College Park is available for use by non-NARA groups and organizations? 1280.85 Section 1280.85 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE...

  16. 36 CFR 1280.87 - Does NARA charge fees for the use of public areas in the National Archives at College Park?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Does NARA charge fees for the use of public areas in the National Archives at College Park? 1280.87 Section 1280.87 Parks, Forests... College Park, Md § 1280.87 Does NARA charge fees for the use of public areas in the National Archives...

  17. 36 CFR 1280.85 - What space in the National Archives at College Park is available for use by non-NARA groups and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false What space in the National Archives at College Park is available for use by non-NARA groups and organizations? 1280.85 Section 1280.85 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NARA FACILITIES USE...

  18. Early Learnings from the National Library of New Zealand's National Digital Heritage Archive Project

    ERIC Educational Resources Information Center

    Knight, Steve

    2010-01-01

    Purpose: The purpose of this paper is to provide a brief description of the digital preservation programme at the National Library of New Zealand. Design/methodology/approach: Following a description of the legislative and strategic context for digital preservation in New Zealand, details are provided of the system for the National Digital…

  19. Access to the Archives of United Nations Agencies: A RAMP Study with Guidelines.

    ERIC Educational Resources Information Center

    Ulate-Segura, Bodil

    Prepared under contract with the International Council on Archives (ICA), this study reviews expanded applications of archival research, the growing popular demand for information, and the resultant effect on the role of archives and archivists, especially in terms of access to records. Following an introductory discussion of the concept and role…

  20. 36 CFR 1280.64 - What entrance should I use to enter the National Archives at College Park?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... normal business hours described in 36 CFR 1253.2. Commercial deliveries must be made at the loading dock... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false What entrance should I use to enter the National Archives at College Park? 1280.64 Section 1280.64 Parks, Forests, and Public...

  1. 36 CFR 1280.64 - What entrance should I use to enter the National Archives at College Park?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... normal business hours described in 36 CFR 1253.2. Commercial deliveries must be made at the loading dock... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true What entrance should I use to enter the National Archives at College Park? 1280.64 Section 1280.64 Parks, Forests, and Public...

  2. 36 CFR 1280.64 - What entrance should I use to enter the National Archives at College Park?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... normal business hours described in 36 CFR 1253.2. Commercial deliveries must be made at the loading dock... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false What entrance should I use to enter the National Archives at College Park? 1280.64 Section 1280.64 Parks, Forests, and Public...

  3. 36 CFR 1280.64 - What entrance should I use to enter the National Archives at College Park?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... normal business hours described in 36 CFR 1253.2. Commercial deliveries must be made at the loading dock... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false What entrance should I use to enter the National Archives at College Park? 1280.64 Section 1280.64 Parks, Forests, and Public...

  4. 36 CFR 1280.64 - What entrance should I use to enter the National Archives at College Park?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... normal business hours described in 36 CFR 1253.2. Commercial deliveries must be made at the loading dock... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false What entrance should I use to enter the National Archives at College Park? 1280.64 Section 1280.64 Parks, Forests, and Public...

  5. Archives in Pakistan

    ERIC Educational Resources Information Center

    Haider, Syed Jalaluddin

    2004-01-01

    This article traces the origins and development of archives in Pakistan. The focus is on the National Archives of Pakistan, but also includes a discussion of the archival collections at the provincial and district levels. This study further examines the state of training facilities available to Pakistani archivists. Archival development has been…

  6. Data archiving

    NASA Technical Reports Server (NTRS)

    Pitts, David

    1991-01-01

    The viewgraphs of a discussion on data archiving presented at the National Space Science Data Center (NSSDC) Mass Storage Workshop is included. The mass storage system at the National Center for Atmospheric Research (NCAR) is described. Topics covered in the presentation include product goals, data library systems (DLS), client system commands, networks, archival devices, DLS features, client application systems, multiple mass storage devices, and system growth.

  7. Radiobiologically guided optimisation of the prescription dose and fractionation scheme in radiotherapy using BioSuite

    PubMed Central

    Uzan, J; Nahum, A E

    2012-01-01

    Objective Radiobiological models provide a means of evaluating treatment plans. Keeping in mind their inherent limitations, they can also be used prospectively to design new treatment strategies which maximise therapeutic ratio. We propose here a new method to customise fractionation and prescription dose. Methods To illustrate our new approach, two non-small cell lung cancer treatment plans and one prostate plan from our archive are analysed using the in-house software tool BioSuite. BioSuite computes normal tissue complication probability and tumour control probability using various radiobiological models and can suggest radiobiologically optimal prescription doses and fractionation schemes with limited toxicity. Results Dose–response curves present varied aspects depending on the nature of each case. The optimisation process suggests doses and fractionation schemes differing from the original ones. Patterns of optimisation depend on the degree of conformality, the behaviour of the normal tissue (i.e. “serial” or “parallel”), the volume of the tumour and the parameters of clonogen proliferation. Conclusion Individualising the prescription dose and number of fractions with the help of BioSuite results in improved therapeutic ratios as evaluated by radiobiological models. PMID:22457318

  8. The National Center for Atmospheric Research (NCAR) Research Data Archive: a Data Education Center

    NASA Astrophysics Data System (ADS)

    Peng, G. S.; Schuster, D.

    2015-12-01

    The National Center for Atmospheric Research (NCAR) Research Data Archive (RDA), rda.ucar.edu, is not just another data center or data archive. It is a data education center. We not only serve data, we TEACH data. Weather and climate data is the original "Big Data" dataset and lessons learned while playing with weather data are applicable to a wide range of data investigations. Erroneous data assumptions are the Achilles heel of Big Data. It doesn't matter how much data you crunch if the data is not what you think it is. Each dataset archived at the RDA is assigned to a data specialist (DS) who curates the data. If a user has a question not answered in the dataset information web pages, they can call or email a skilled DS for further clarification. The RDA's diverse staff—with academic training in meteorology, oceanography, engineering (electrical, civil, ocean and database), mathematics, physics, chemistry and information science—means we likely have someone who "speaks your language." Data discovery is another difficult Big Data problem; one can only solve problems with data if one can find the right data. Metadata, both machine and human-generated, underpin the RDA data search tools. Users can quickly find datasets by name or dataset ID number. They can also perform a faceted search that successively narrows the options by user requirements or simply kick off an indexed search with a few words. Weather data formats can be difficult to read for non-expert users; it's usually packed in binary formats requiring specialized software and parameter names use specialized vocabularies. DSs create detailed information pages for each dataset and maintain lists of helpful software, documentation and links of information around the web. We further grow the level of sophistication of the users with tips, tutorials and data stories on the RDA Blog, http://ncarrda.blogspot.com/. How-to video tutorials are also posted on the NCAR Computational and Information Systems

  9. STP K Basin Sludge Sample Archive at the Pacific Northwest National Laboratory FY2014

    SciTech Connect

    Fiskum, Sandra K.; Smoot, Margaret R.; Schmidt, Andrew J.

    2014-06-01

    The Pacific Northwest National Laboratory (PNNL) currently houses 88 samples (~10.5 kg) of K Basin sludge (81 wet and seven dry samples) on behalf of the Sludge Treatment Project (STP), which is managed for the U.S. Department of Energy (DOE) by the CH2M Hill Plateau Remediation Company (CHPRC). Selected samples are intended to serve, in part, as sentinels to enhance understanding of sludge properties after long-term storage, and thus enhance understanding of sludge behavior following transfer to sludge transfer and storage containers (STSCs) and storage at the Hanford 200 Area central plateau. In addition, remaining samples serve in contingency for future testing requirements. At PNNL, the samples are tracked and maintained under a prescriptive and disciplined monthly sample-monitoring program implemented by PNNL staff. This report updates the status of the K Basin archive sludge sample inventory to April 2014. The previous inventory status report, PNNL 22245 (Fiskum et al. 2013, limited distribution report), was issued in February of 2013. This update incorporates changes in the inventory related to repackaging of 17 samples under test instructions 52578 TI052, K Basin Sludge Sample Repackaging for Continued Long Term Storage, and 52578 TI053, K Basin Sludge Sample Repackaging Post-2014 Shear Strength Measurements. Note that shear strength measurement results acquired in 2014 are provided separately. Specifically, this report provides the following: • a description of the K Basin sludge sample archive program and the sample inventory • a summary and images of the samples that were repackaged in April 2014 • up-to-date images and plots of the settled density and water loss from all applicable samples in the inventory • updated sample pedigree charts, which provide a roadmap of the genesis and processing history of each sample in the inventory • occurrence and deficiency reports associated with sample storage and repackaging

  10. Introduction to Radiobiology of Targeted Radionuclide Therapy

    PubMed Central

    Pouget, Jean-Pierre; Lozza, Catherine; Deshayes, Emmanuel; Boudousq, Vincent; Navarro-Teulon, Isabelle

    2015-01-01

    During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a multidisciplinary approach that involves the cooperation of specialists in several research fields. Among them, radiobiologists investigate the biological effects of ionizing radiation, specifically the molecular and cellular mechanisms involved in the radiation response. Most of the knowledge about radiation effects concerns external beam radiation therapy (EBRT) and radiobiology has then strongly contributed to the development of this therapeutic approach. Similarly, radiobiology and dosimetry are also assumed to be ways for improving TRT, in particular in the therapy of solid tumors, which are radioresistant. However, extrapolation of EBRT radiobiology to TRT is not straightforward. Indeed, the specific physical characteristics of TRT (heterogeneous and mixed irradiation, protracted exposure, and low absorbed dose rate) differ from those of conventional EBRT (homogeneous irradiation, short exposure, and high absorbed dose rate), and consequently the response of irradiated tissues might be different. Therefore, specific TRT radiobiology needs to be explored. Determining dose–effect correlation is also a prerequisite for rigorous preclinical radiobiology studies because dosimetry provides the necessary referential to all TRT situations. It is required too for developing patient-tailored TRT in the clinic in order to estimate the best dose for tumor control, while protecting the healthy tissues, thereby improving therapeutic efficacy. Finally, it will allow to determine the relative contribution of targeted effects (assumed to be dose-related) and non-targeted effects (assumed to be non-dose-related) of ionizing radiation. However, conversely to EBRT where it is routinely used, dosimetry is still challenging in TRT. Therefore, it constitutes with radiobiology, one of the main challenges of

  11. Airborne microorganisms cultivable on naturally ventilated document repositories of the National Archive of Cuba.

    PubMed

    Borrego, Sofía; Perdomo, Ivette

    2016-02-01

    The quality of the indoor air can provide very useful information for the artwork conservation. The aim of the study was to evaluate the microbial concentration inside six document repositories of the National Archive of the Republic of Cuba in two months of 1 year. The repositories are large, high, and have a natural cross-ventilation system. The microbial sampling was done in July 2010 (summer or rainy month) and February 2011 (winter or dry month) using the SAS Super 100 biocollector at 100 L/min. An appropriate selective culture media were used to isolate fungi and bacteria. A high total microbial concentration on the north side of the building in two studied months was observed. The fungal concentrations were significantly higher in July 2010 in all repositories, while the bacterial concentrations were significantly higher mostly in February 2011 only in repositories located on the first and second floor of the building. Eight fungal genera in the indoor air of all environments were isolated. Regardless of the side of the analyzed building, Penicillium, Aspergillus, and Cladosporium were the predominant genera. Aspergillus flavus and Aspergillus niger were the species isolated in almost all of the analyzed repositories in the studied months. Gram-positive bacteria prevailed among bacterial groups isolated from indoor air repositories, and some percentages corresponded to the genera Bacillus and Streptomyces. In Cuba, the temperature and relative humidity are high during the whole year but the natural ventilation plays an important role in retarding microbial growth on materials. PMID:26498813

  12. RNRFA: an R package to interact with the UK National River Flow Archive

    NASA Astrophysics Data System (ADS)

    Vitolo, Claudia; Fry, Matthew; Buytaert, Wouter

    2015-04-01

    The UK National River Flow Archive (NRFA) serves daily streamflow data, spatial rainfall averages and information regarding elevation, geology, land cover and FEH related catchment descriptors. In order to view, filter and download data, users are required to use a web interface which has several limitations. For instance, only one station can be selected at a time, therefore the bulk download of multiple datasets (whenever possible) can become a rather tedious task. An application programming interface to the NRFA web services is currently under development but no application has been built yet to interact with its services. A joint effort between Imperial College London and the UK Centre of Ecology and Hydrology has led to the development of an open source project, the R package "rnrfa", to provide alternative and more efficient access and usage of the following NRFA web services: - Metadata catalogue - Catalogue filters based on a geographical bounding-box - Catalogue filters based on metadata entries - Gauged daily data for about 400 stations available in WaterML2 format, the OGC standard used to describe hydrological time series. The rnrfa package, beside being a convenient stand-alone application, is also an ideal back-end tool for virtual observatory type web applications as it simplifies the interaction between data provider and data consumers.

  13. 36 CFR 1235.46 - What electronic media may be used for transferring records to the National Archives of the United...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... to the National Archives of the United States. (See 36 CFR 1236.28 for the requirements governing the...) Compact-Disk, Read Only Memory (CD-ROM) and Digital Video Disks (DVDs). Agencies may use CD-ROMs and...

  14. 36 CFR 1235.46 - What electronic media may be used for transferring records to the National Archives of the United...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... to the National Archives of the United States. (See 36 CFR 1236.28 for the requirements governing the...) Compact-Disk, Read Only Memory (CD-ROM) and Digital Video Disks (DVDs). Agencies may use CD-ROMs and...

  15. An Online National Archive of Multiple-Choice Questions for Astro 101 and the Development of the Question Complexity Rubric

    NASA Astrophysics Data System (ADS)

    Cormier, S.; Prather, E.; Brissenden, G.

    2011-09-01

    We are developing a national archive of multiple-choice questions for use in the Astronomy 101 classroom. These questions are intended to supplement an instructor's implementation of Think-Pair-Share or for their assessment purposes (i.e., exams and homework). We are also developing the Question Complexity Rubric (QCR) to guide members of the Astro 101 teaching and learning community in assisting us with hierarchically ranking questions in this archive based on their conceptual complexity. Using the QCR, a score is assigned to differentiate each question based on the cognitive steps necessary to comprehensively explain the reasoning pathway to the correct answer. The lowest QCR score is given to questions with a reasoning pathway requiring only declarative knowledge. The highest QCR score is given to questions with a reasoning pathway that requires multiple connected cognitive steps. When completed, the online question archive will provide users with the utility to 1) use the QCR to score questions 2) search for and download questions based on topic and/or QCR score, and 3) add their own questions to the archive. Stop by our poster to test your skills at determining question complexity by trying out the QCR with our sample questions.

  16. 36 CFR 1254.86 - May I use a personal paper-to-paper copier at the National Archives at College Park?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false May I use a personal paper-to-paper copier at the National Archives at College Park? 1254.86 Section 1254.86 Parks, Forests, and... § 1254.86 May I use a personal paper-to-paper copier at the National Archives at College Park? (a) At...

  17. The Question Complexity Rubric: Development and Application for a National Archive of Astro 101 Multiple-Choice Questions

    NASA Astrophysics Data System (ADS)

    Cormier, Sebastien; Prather, E. E.; Brissenden, G.; Collaboration of Astronomy Teaching Scholars CATS

    2011-01-01

    For the last two years we have been developing an online national archive of multiple-choice questions for use in the Astro 101 classroom. These questions are intended to either supplement an instructor's implementation of Think-Pair-Share or be used for assessment purposes (i.e. exams and homework). In this talk we will describe the development, testing and implementation of the Question Complexity Rubric (QCR), which is designed to guide the ranking of questions in this archive based on their conceptual complexity. Using the QCR, a score is assigned to differentiate each question based on the cognitive steps necessary to comprehensively explain the reasoning pathway to the correct answer. The lowest QCR score is given to questions with a reasoning pathway requiring only declarative knowledge whereas the highest QCR score is given to questions that require multiple pathways of multi-step reasoning. When completed, the online question archive will provide users with the utility to 1) search for and download questions based on subject and average QCR score, 2) use the QCR to score questions, and 3) add their own questions to the archive. We will also discuss other potential applications of the QCR, such as how it informs our work in developing and testing of survey instruments by allowing us to calibrate the range of question complexity. This material is based upon work supported by the National Science Foundation under Grant No. 0715517, a CCLI Phase III Grant for the Collaboration of Astronomy Teaching Scholars (CATS). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

  18. [Aerospace radiobiology: 35 years (1960-1995)].

    PubMed

    Ushakov, I B; Davydov, B I

    1996-01-01

    The paper gives a brief history of the birth and development of aerospace radiobiology at the Institute of Aviation and Space Medicine. It covers from the first radiobiological investigations in space to the insurance of radiation safety for helicopter air crews who took part in cleaning-up operations of consequences of the Chernobyl accident. The workers of the Radiobiological Laboratory have performed some research theoretical and practical tasks in the interests of aviation and space, civil and military medicine: the impact of gravitation and radiation on genetic structures has been studied, a radiation safety system for vehicles of different use has been developed, new principles in the standardization of EMF for radiofrequency and microwave bands have been proposed, the new radioprotective agent indralin (B, B-190) has been discovered, which is accepted for supply and used in rotary wing aircraft pilots during liquidation works at the Chernobyl atomic power station. New experimental data on the combined effects of radiation and non-radiation flight factors have been obtained. Basically new data on the mechanism of action of ionizing and non-ionizing radiation on the brain have been also gained, a system for assessing the health and rehabilitation of pilots that cleaned-up the Chernobyl accident has been developed. Professor Pavel Petrovich Saksonov, RF Honoured Scientist, has the honour to create a school of aerospace radiobiology. PMID:8963185

  19. The Anatomische Gesellschaft and National Socialism: an analysis based on newly available archival material.

    PubMed

    Winkelmann, Andreas

    2015-09-01

    The newly available scientific estate of Heinrich von Eggeling (1869-1954), long-time secretary of the Anatomische Gesellschaft (AG), allows a more profound analysis of how this scientific association went through the period of the "Third Reich". At the first meeting under the new rulers in 1934, von Eggeling and Siegfried Mollier prevented their board colleague Martin Heidenhain from giving an introductory talk because they (not unjustly) feared anti-Jewish protests, but also because many anatomy professors, like other German scholars, were fervent nationalists who welcomed Hitler and largely accepted the expulsion of Jewish and other colleagues as 'inevitable' for national renewal. Many persecuted members nevertheless remained on the membership lists and the AG never officially introduced anti-Jewish bylaws. Eggeling and his like-minded colleagues successfully defended the international status of the AG, though not so much against the Nazi authorities but against a younger generation of anatomists who were willing to benefit from the new political situation and strived for their own German anatomical association. The available archival material suggests that the motivation of the established leading members of the AG to take this specific path was not rooted in opposition to the new rulers but rather in defence of their traditional status of reputed professors running a time-honoured, world leading society. This made international reputation an important guideline for many decisions. While they did ward off attempts by the younger generation to politicise the AG, their post-war calls for an apolitical science remain ambivalent, as their own stance had not always been apolitical. PMID:26117073

  20. Upgrades to NDSF Vehicle Camera Systems and Development of a Prototype System for Migrating and Archiving Video Data in the National Deep Submergence Facility Archives at WHOI

    NASA Astrophysics Data System (ADS)

    Fornari, D.; Howland, J.; Lerner, S.; Gegg, S.; Walden, B.; Bowen, A.; Lamont, M.; Kelley, D.

    2003-12-01

    In recent years, considerable effort has been made to improve the visual recording capabilities of Alvin and ROV Jason. This has culminated in the routine use of digital cameras, both internal and external on these vehicles, which has greatly expanded the scientific recording capabilities of the NDSF. The UNOLS National Deep Submergence Facility (NDSF) archives maintained at Woods Hole Oceanograpic Institution (WHOI) are the repository for the diverse suite of photographic still images (both 35mm and recently digital), video imagery, vehicle data and navigation, and near-bottom side-looking sonar data obtained by the facility vehicles. These data comprise a unique set of information from a wide range of seafloor environments over the more than 25 years of NDSF operations in support of science. Included in the holdings are Alvin data plus data from the tethered vehicles- ROV Jason, Argo II, and the DSL-120 side scan sonar. This information conservatively represents an outlay in facilities and science costs well in excess of \\$100 million. Several archive related improvement issues have become evident over the past few years. The most critical are: 1. migration and better access to the 35mm Alvin and Jason still images through digitization and proper cataloging with relevant meta-data, 2. assessing Alvin data logger data, migrating data on older media no longer in common use, and properly labeling and evaluating vehicle attitude and navigation data, 3. migrating older Alvin and Jason video data, especially data recorded on Hi-8 tape that is very susceptible to degradation on each replay, to newer digital format media such as DVD, 4. improving the capabilities of the NDSF archives to better serve the increasingly complex needs of the oceanographic community, including researchers involved in focused programs like Ridge2000 and MARGINS, where viable distributed databases in various disciplinary topics will form an important component of the data management structure

  1. Workshop on Radiobiological Effectiveness of Neutrons

    NASA Astrophysics Data System (ADS)

    Stapleton, G. E.; Thomas, R. G.; Thiessen, J. W.

    1985-09-01

    The radiobiological effectiveness (RBE) of neutrons has become the subject of some heated discussions in both scientific and radiation-protection oriented communities. This has become especially so since the realization that neutron exposures of A-bomb survivors in Hiroshima were considerably lower than previously assumed, thus devaluating the importance of what we thought was a solid human data base. At the same time, more recent data from radiobiological research appeared to indicate that, at least for some biological endpoints, the RBE of neutrons at low doses and low dose rates was increased dramatically compared to the RBE at higher dose and dose rates. As a consequence, the protection of health against neutrons became a subject of some urgency. The objective of this workshop was to evaluate the existing data base in order to determine the need for additional research in this field.

  2. Workshop on radiobiological effectiveness of neutrons

    SciTech Connect

    Stapleton, G.E.; Thomas, R.G.; Thiessen, J.W.

    1985-09-01

    The radiobiological effectiveness (RBE) of neutrons has become the subject of some heated discussions in both scientific and radiation-protection oriented communities. This has become especially so since the realization that neutron exposures of A-bomb survivors in Hiroshima were considerably lower than previously assumed, thus ''devaluating'' the importance of what we thought was a solid human data base. At the same time, more recent data from radiobiological research appeared to indicate that, at least for some biological endpoints, the RBE of neutrons at low doses and low dose rates was increased dramatically compared to the RBE at higher dose and dose rates. As a consequence, the protection of health against neutrons became a subject of some urgency. The objective of this workshop was to evaluate the existing data base in order to determine the need for additional research in this field. 22 refs., 3 figs., 6 tabs.

  3. A Case Study in Collaboration: Looking Back at the National Graphic Design Archive

    ERIC Educational Resources Information Center

    Remington, R. Roger

    2004-01-01

    Inspired by the 1980s interest in graphic design history, an initially productive, but difficult to sustain, collaboration among three American universities from the late 1980s to the mid-1990s, is the subject of this case study. The ideas behind a much-needed archival consortium, its organization and its difficulties in sustaining collaboration…

  4. Directory of National Standards Relating to Archives Administration and Records Management: A RAMP Study.

    ERIC Educational Resources Information Center

    Roper, Michael

    Prepared under contract with the International Council on Archives (ICA), this study is designed to provide archivists, records managers, and other interested professionals with both a reference and planning tool in the area of methods, norms and standards. The study is based on responses to a questionnaire which was submitted to selected…

  5. Dosimetry for radiobiology experiments at GANIL

    NASA Astrophysics Data System (ADS)

    Durantel, Florent; Balanzat, Emmanuel; Cassimi, Amine; Chevalier, François; Ngono-Ravache, Yvette; Madi, Toiammou; Poully, Jean-Christophe; Ramillon, Jean-Marc; Rothard, Hermann; Ropars, Frédéric; Schwob, Lucas; Testard, Isabelle; Saintigny, Yannick

    2016-04-01

    Mainly encouraged by the increasing application of ion beams for cancer treatment (hadron-therapy) including carbon beams, the use of heavy ion facilities for radiobiology is expanding rapidly today. As an alternative to dedicated centers for treatment and medical research, accelerators like GANIL offer the possibility to undertake such experiments. Since 20 years, CIMAP, reinforced 15 years ago by the biological host laboratory LARIA, has been receiving researchers in radiobiology and assisted them in performing experiments in different fields such as hadron-therapy, space radioprotection and fundamental biological and physico-chemical mechanisms. We present here a short description of the beam line and the on-line equipments that allow the automatic irradiation of up to 24 biological samples at once. We also developed an original on-line beam monitoring procedure for low ion flux (low dose rates) based on the measurement of the K-shell X-rays emitted from a thin iron foil. This detector is calibrated on an absolute scale before each experiment by counting etched tracks on an irradiated CR39 polymer plate. We present the performances and limits of this method and finally give typical fluence (dose) uncertainties for a standard irradiation in radiobiology.

  6. 36 CFR 1235.46 - What electronic media may be used for transferring records to the National Archives of the United...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Division (NWCS), 8601 Adelphi Road, College Park, MD 20740, phone number (301) 837-2903, or the National... Adelphi Road, College Park, MD 20740, phone number (301) 837-1578, to initiate the transfer discussions... to the National Archives of the United States. (See 36 CFR 1236.28 for the requirements governing...

  7. Sci-Tech Archives and Manuscript Collections.

    ERIC Educational Resources Information Center

    Mount, Ellis, Ed.

    1989-01-01

    Selected collections of scientific and technical archives and manuscripts described in eight articles include the Edison Archives; American Museum of Natural History Library; MIT (Massachusetts Institute of Technology) Institute Archives and Special Collections; National Archives; Dard Hunter Paper Museum; American Zoo and Aquarium Archives; and…

  8. Pharmaceuticals and personal care products in archived U.S. biosolids from the 2001 EPA National Sewage Sludge Survey.

    PubMed

    McClellan, Kristin; Halden, Rolf U

    2010-01-01

    In response to the U.S. National Academies' call for a better assessment of chemical pollutants contained in the approximately 7 million dry tons of digested municipal sludge produced annually in the United States, the mean concentration of 72 pharmaceuticals and personal care products (PPCP) were determined in 110 biosolids samples collected by the U.S. Environmental Protection Agency (EPA) in its 2001 National Sewage Sludge Survey. Composite samples of archived biosolids, collected at 94 U.S. wastewater treatment plants from 32 states and the District of Columbia, were analyzed by liquid chromatography tandem mass spectrometry using EPA Method 1694. Thirty-eight (54%) of the 72 analytes were detected in at least one composite sample at concentrations ranging from 0.002 to 48 mg kg(-1) dry weight. Triclocarban and triclosan were the most abundant analytes with mean concentrations of 36 +/- 8 and 12.6 +/- 3.8 mg kg(-1) (n = 5), respectively, accounting for 65% of the total PPCP mass found. The loading to U.S. soils from nationwide biosolids recycling was estimated at 210-250 metric tons per year for the sum of the 72 PPCPs investigated. The results of this nationwide reconnaissance of PPCPs in archived U.S. biosolids mirror in contaminant occurrences, frequencies and concentrations, those reported by the U.S. EPA for samples collected in 2006/2007. This demonstrates that PPCP releases in U.S. biosolids have been ongoing for many years and the most abundant PPCPs appear to show limited fluctuations in mass over time when assessed on a nationwide basis. The here demonstrated use of five mega composite samples holds promise for conducting cost-effective, routine monitoring on a regional and national basis. PMID:20106500

  9. National Space Science Data Center data archive and distribution service (NDADS) automated retrieval mail system user's guide

    NASA Technical Reports Server (NTRS)

    Perry, Charleen M.; Vansteenberg, Michael E.

    1992-01-01

    The National Space Science Data Center (NSSDC) has developed an automated data retrieval request service utilizing our Data Archive and Distribution Service (NDADS) computer system. NDADS currently has selected project data written to optical disk platters with the disks residing in a robotic 'jukebox' near-line environment. This allows for rapid and automated access to the data with no staff intervention required. There are also automated help information and user services available that can be accessed. The request system permits an average-size data request to be completed within minutes of the request being sent to NSSDC. A mail message, in the format described in this document, retrieves the data and can send it to a remote site. Also listed in this document are the data currently available.

  10. 36 CFR 1235.46 - What electronic media may be used for transferring records to the National Archives of the United...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... to the National Archives of the United States. (See 36 CFR 1236.28 for the requirements governing the... standard below applies. DLTtape IV with a DLT 4000 drive . . . ISO/IEC 15307 (incorporated by reference see, § 1235.4). DLTtape IV with a DLT 7000 drive . . . ISO/IEC 15896 (incorporated by reference see, §...

  11. The Civil War: A Survey. Featuring Original Documents from the National Archives and Records Administration. Volume 6. Teaching with Primary Sources Series.

    ERIC Educational Resources Information Center

    West, Jean M., Ed.

    This unit of study (for grades 5-8 and up) about the U.S. Civil War features original documents from the National Archives and Records Administration. All the records used in the unit reflect the actions of the federal government or citizens' responses to these actions. These records were selected for their historical value, their legibility and…

  12. Pharmaceuticals and Personal Care Products in Archived U.S. Biosolids from the 2001 EPA National Sewage Sludge Survey

    PubMed Central

    McClellan, Kristin; Halden, Rolf U.

    2010-01-01

    In response to the U.S. National Academies’ call for a better assessment of chemical pollutants contained in the approximately 6.9 million dry tons of digested municipal sludge produced annually in the United States, the mean concentration of 72 pharmaceuticals and personal care products (PPCP) were determined in 110 biosolids samples collected by the U.S. Environmental Protection Agency (EPA) in its 2001 National Sewage Sludge Survey. Composite samples of archived biosolids, collected at 94 U.S. wastewater treatment plants from 32 states and the District of Columbia, were analyzed by liquid chromatography tandem mass spectrometry using EPA Method 1694. Thirty-eight (54%) of the 72 analytes were detected in at least one composite sample at concentrations ranging from 0.002 to 48 mg kg−1 dry weight. Triclocarban and triclosan were the most abundant analytes with mean concentrations of 36 ± 8 and 12.6 ± 3.8 mg kg−1 (n = 5), respectively, accounting for 65% of the total PPCP mass found. The loading to U.S. soils from nationwide biosolids recycling was estimated at 210–250 metric tons per year for the sum of the 72 PPCPs investigated. The results of this nationwide reconnaissance of PPCPs in archived U.S. biosolids mirror in contaminant occurrences, frequencies and concentrations, those reported by the U.S. EPA for samples collected in 2006/07. This demonstrates that PPCP releases in U.S. biosolids have been ongoing for many years and the most abundant PPCPs appear to show limited fluctuations in mass over time when assessed on a nationwide basis. The here demonstrated use of five mega composite samples holds promise for conducting cost-effective, routine monitoring on a regional basis. PMID:20106500

  13. 3-D Imaging Based, Radiobiological Dosimetry

    PubMed Central

    Sgouros, George; Frey, Eric; Wahl, Richard; He, Bin; Prideaux, Andrew; Hobbs, Robert

    2008-01-01

    Targeted radionuclide therapy holds promise as a new treatment against cancer. Advances in imaging are making it possible to evaluate the spatial distribution of radioactivity in tumors and normal organs over time. Matched anatomical imaging such as combined SPECT/CT and PET/CT have also made it possible to obtain tissue density information in conjunction with the radioactivity distribution. Coupled with sophisticated iterative reconstruction algorithims, these advances have made it possible to perform highly patient-specific dosimetry that also incorporates radiobiological modeling. Such sophisticated dosimetry techniques are still in the research investigation phase. Given the attendant logistical and financial costs, a demonstrated improvement in patient care will be a prerequisite for the adoption of such highly-patient specific internal dosimetry methods. PMID:18662554

  14. [Claudius Regaud (1870-1940): A pioneer of radiobiology and radiotherapy].

    PubMed

    Foray, N

    2012-01-01

    Born in 1870, Claudius Regaud was a pioneer of radiobiology and radiotherapy. As histologist, he developed a new staining technique that allowed him to describe in detail all the reproduction system of a number of animal models. As radiobiologist, he contradicted the interpretations of Tribondeau and Bergonié about relationships between cell proliferation and radiosensitivity. In 1908, he suggested that chromatin was the main target of radiation. As physician, he defined the first bases of anti-cancer radiation treatments and treated patients suffering from incurable cancer from 1911. As military doctor, he organized war hospitals by creating multidisciplinary teams for the surgery of hurts. Organizer, he was one of the founders of the League against Cancer. As radiotherapist and brachytherapist, he contributed to make Institut Curie an international reference center for research and teaching, with nearly a thousand treated patients. As globe-trotter, he was at the origin of the creation of numerous worldwide radiotherapy and radiobiology centers. He died in December 1940 and let an impressive but still misknown scientific heritage. A re-reading of the familial archives and the Regaud Fund of Institut Curie is the occasion to remind the contribution of Regaud. PMID:22818408

  15. Software Tools for Data Mining the Archives of the National Virtual Observatory. I. Quick & Dirty CCD Stellar Photometry (QDPHOT)

    NASA Astrophysics Data System (ADS)

    Mighell, K. J.

    2000-12-01

    I present a new fast CCD stellar photometry {iraf} task called {qdphot} (Quick & Dirty PHOTometry) which quickly produces good CCD stellar photometry from two CCD images of a star field. {qdphot} was designed to be a data mining tool for finding high-quality stellar observations in the data archives of the National Virtual Observatory. {qdphot} typically takes just a few seconds to analyze two {Hubble Space Telescope} WFPC2 observations of Local Group star clusters. {qdphot} is also suitable for real-time data-quality analysis of CCD observations; on-the-fly instrumental color-magnitude diagrams can be produced at the telescope console during the few seconds between CCD readouts. More information about {qdphot} is available at the following website: [1mm] {http://www.noao.edu/staff/mighell/qdphot/} This research is supported by a grant from the National Aeronautics and Space Administration (NASA), Order No. S-67046-F, which was awarded by the Long-Term Space Astrophysics Program (NRA 95-OSS-16).

  16. Latin American Archives.

    ERIC Educational Resources Information Center

    Belsunce, Cesar A. Garcia

    1983-01-01

    Examination of the situation of archives in four Latin American countries--Argentina, Brazil, Colombia, and Costa Rica--highlights national systems, buildings, staff, processing of documents, accessibility and services to the public and publications and extension services. (EJS)

  17. In vitro irradiation system for radiobiological experiments

    PubMed Central

    2013-01-01

    Background Although two-dimensional (2-D) monolayer cell cultures provide important information on basic tumor biology and radiobiology, they are not representative of the complexity of three-dimensional (3-D) solid tumors. In particular, new models reproducing clinical conditions as closely as possible are needed for radiobiological studies to provide information that can be translated from bench to bedside. Methods We developed a novel system for the irradiation, under sterile conditions, of 3-D tumor spheroids, the in vitro model considered as a bridge between the complex architectural organization of in vivo tumors and the very simple one of in vitro monolayer cell cultures. The system exploits the same equipment as that used for patient treatments, without the need for dedicated and highly expensive instruments. To mimic the passage of radiation beams through human tissues before they reach the target tumor mass, 96-multiwell plates containing the multicellular tumor spheroids (MCTS) are inserted into a custom-built phantom made of plexiglass, the material most similar to water, the main component of human tissue. Results The system was used to irradiate CAEP- and A549-derived MCTS, pre-treated or not with 20 μM cisplatin, with a dose of 20 Gy delivered in one session. We also tested the same treatment schemes on monolayer CAEP and A549 cells. Our preliminary results indicated a significant increment in radiotoxicity 20 days after the end of irradiation in the CAEP spheroids pre-treated with cisplatin compared to those treated with cisplatin or irradiation alone. Conversely, the effect of the radio- chemotherapy combination in A549-derived MCTS was similar to that induced by cisplatin or irradiation alone. Finally, the 20 Gy dose did not affect cell survival in monolayer CAEP and A549 cells, whereas cisplatin or cisplatin plus radiation caused 100% cell death, regardless of the type of cell line used. Conclusions We set up a system for the irradiation

  18. The National Institutes of Health Clinical Center Digital Imaging Network, Picture Archival and Communication System, and Radiology Information System.

    PubMed

    Goldszal, A F; Brown, G K; McDonald, H J; Vucich, J J; Staab, E V

    2001-06-01

    In this work, we describe the digital imaging network (DIN), picture archival and communication system (PACS), and radiology information system (RIS) currently being implemented at the Clinical Center, National Institutes of Health (NIH). These systems are presently in clinical operation. The DIN is a redundant meshed network designed to address gigabit density and expected high bandwidth requirements for image transfer and server aggregation. The PACS projected workload is 5.0 TB of new imaging data per year. Its architecture consists of a central, high-throughput Digital Imaging and Communications in Medicine (DICOM) data repository and distributed redundant array of inexpensive disks (RAID) servers employing fiber-channel technology for immediate delivery of imaging data. On demand distribution of images and reports to clinicians and researchers is accomplished via a clustered web server. The RIS follows a client-server model and provides tools to order exams, schedule resources, retrieve and review results, and generate management reports. The RIS-hospital information system (HIS) interfaces include admissions, discharges, and transfers (ATDs)/demographics, orders, appointment notifications, doctors update, and results. PMID:11442088

  19. National inventory of perfluoroalkyl substances in archived U.S. biosolids from the 2001 EPA National Sewage Sludge Survey

    PubMed Central

    Venkatesan, Arjun K.; Halden, Rolf U.

    2013-01-01

    Using liquid chromatography tandem mass spectrometry, we determined the first nationwide inventories of 13 perfluoroalkyl substances (PFASs) in U.S. biosolids via analysis of samples collected by the U.S. Environmental Protection Agency in the 2001 National Sewage Sludge Survey. Perfluorooctane sulfonate [PFOS; 403 ± 127 ng/g dry weight (dw)] was the most abundant PFAS detected in biosolids composites representing 32 U.S. states and the District of Columbia, followed by perfluorooctanoate [PFOA; 34 ± 22 ng/g dw] and perfluorodecanoate [PFDA; 26 ± 20 ng/g dw]. Mean concentrations in U.S. biosolids of the remaining ten PFASs ranged between 2 and 21 ng/g dw. Interestingly, concentrations of PFOS determined here in biosolids collected prior to the phase-out period (2002) were similar to levels reported in the literature for recent years. The mean load of ΣPFASs in U.S. biosolids was estimated at 2749–3450 kg/year, of which about 1375–2070 kg is applied on agricultural land and 467–587 kg goes to landfills as an alternative disposal route. This study informs the risk assessment of PFASs by furnishing national inventories of PFASs occurrence and environmental release via biosolids application on land. PMID:23562984

  20. Biophysical and biomathematical adventures in radiobiology

    SciTech Connect

    Scott, B.R.

    1991-01-01

    Highlights of my biophysical and biomathematical adventures in radiobiology is presented. Early adventures involved developing state-vector models'' for specific harmful effects (cell killing, life shortening) of exposure to radiation. More recent adventures led to developing hazard-function models'' for predicting biological effects (e.g., cell killing, mutations, tumor induction) of combined exposure to different toxicants. Hazard-function models were also developed for predicting harm to man from exposure to large radiation doses. Major conclusions derived from the modeling adventures are as follows: (1) synergistic effects of different genotoxic agents should not occur at low doses; (2) for exposure of the lung or bone marrow to large doses of photon radiation, low rates of exposure should be better tolerated than high rates; and (3) for some types of radiation (e.g., alpha particles and fission neutrons), moderate doses delivered at a low rate may be more harmful than the same dose given at a high rate. 53 refs., 7 figs.

  1. Radiobiological considerations in magna-field irradiation

    SciTech Connect

    Evans, R.G.

    1983-12-01

    Radiobiological considerations are described for total body irradiation (TBI) as given to patients undergoing bone marrow transplantation (BMT). Although much progress has been made in the use of BMT for refractory leukemias, many patients still die from interstitial pneumonia and relapse. Fractionated TBI has been introduced in order to improve leukemic cell kill, while increasing the degree of normal tissue tolerance. Traditionally, bone marrow stem cells, leukemic cells and immunocytes have been considered as having a limited ability to repair radiation damage while cells of lung tissue and intestinal epithelial cells have a greater capacity. During fractionated radiation therapy or continuous low-dose rate exposure, repair of sublethal damage between fractions allows greater recovery in the cells of lung tissue to those in the bone marrow. Clinically, the potential benefit of six fractions over one fraction or low dose-rate TBI has yet to be proved, although there is suggestive evidence for a reduced incidence of interstitial pneumonitis. However, other extraneous factors such as doses to the lung, differences in conditioning regimens, effect of increased delay in BMT for patients receiving fractionated TBI, and the unmeasurable differences between institutions make definite conclusions impossible. Despite this, a consensus for dose fractionation has developed and most centers are moving away from the use of large single dose TBI.

  2. Monte Carlo role in radiobiological modelling of radiotherapy outcomes

    NASA Astrophysics Data System (ADS)

    El Naqa, Issam; Pater, Piotr; Seuntjens, Jan

    2012-06-01

    Radiobiological models are essential components of modern radiotherapy. They are increasingly applied to optimize and evaluate the quality of different treatment planning modalities. They are frequently used in designing new radiotherapy clinical trials by estimating the expected therapeutic ratio of new protocols. In radiobiology, the therapeutic ratio is estimated from the expected gain in tumour control probability (TCP) to the risk of normal tissue complication probability (NTCP). However, estimates of TCP/NTCP are currently based on the deterministic and simplistic linear-quadratic formalism with limited prediction power when applied prospectively. Given the complex and stochastic nature of the physical, chemical and biological interactions associated with spatial and temporal radiation induced effects in living tissues, it is conjectured that methods based on Monte Carlo (MC) analysis may provide better estimates of TCP/NTCP for radiotherapy treatment planning and trial design. Indeed, over the past few decades, methods based on MC have demonstrated superior performance for accurate simulation of radiation transport, tumour growth and particle track structures; however, successful application of modelling radiobiological response and outcomes in radiotherapy is still hampered with several challenges. In this review, we provide an overview of some of the main techniques used in radiobiological modelling for radiotherapy, with focus on the MC role as a promising computational vehicle. We highlight the current challenges, issues and future potentials of the MC approach towards a comprehensive systems-based framework in radiobiological modelling for radiotherapy.

  3. Archives Library Information Center (ALIC) Notes, 1989-1992.

    ERIC Educational Resources Information Center

    ALIC Notes, 1992

    1992-01-01

    The Archives Library Information Center (ALIC) within the National Archives and Records Administration (NARA) collects printed material on archives, manuscripts, and records management. ALIC compiles a database of these materials, sources of archival services and supplies, and information on significant archival projects. "ALIC Notes" is a brief…

  4. Radiobiological evaluation of low dose-rate prostate brachytherapy implants

    NASA Astrophysics Data System (ADS)

    Knaup, Courtney James

    Low dose-rate brachytherapy is a radiation therapy treatment for men with prostate cancer. While this treatment is common, the use of isotopes with varying dosimetric characteristics means that the prescription level and normal organ tolerances vary. Additionally, factors such as prostate edema, seed loss and seed migration may alter the dose distribution within the prostate. The goal of this work is to develop a radiobiological response tool based on spatial dose information which may be used to aid in treatment planning, post-implant evaluation and determination of the effects of prostate edema and seed migration. Aim 1: Evaluation of post-implant prostate edema and its dosimetric and biological effects. Aim 2: Incorporation of biological response to simplify post-implant evaluation. Aim 3: Incorporation of biological response to simplify treatment plan comparison. Aim 4: Radiobiologically based comparison of single and dual-isotope implants. Aim 5: Determine the dosimetric and radiobiological effects of seed disappearance and migration.

  5. [Radiobiological aspects of diagnostic X-ray use in dentistry].

    PubMed

    Hoogeveen, R C; van den Aardweg, G J M J

    2015-05-01

    Soon after the discovery of X-rays, it became clear that their use can cause detrimental effects. The field of radiobiology deals with these detrimental effects. In this article, the theoretical concepts of radiobiology relevant to diagnostic X-ray use are presented. The effects of radiation on living tissues, the relationship between dose and effect, and a translation of these effects into the dental application are discussed. X-rays cannot be considered to be harmless even when used at the relatively low doses as in dentistry. If applied with justification and optimization, the risk to the patient will, however, be small. PMID:26210221

  6. Mixed-field GCR Simulations for Radiobiological Research using Ground Based Accelerators

    NASA Astrophysics Data System (ADS)

    Kim, Myung-Hee Y.; Rusek, Adam; Cucinotta, Francis

    Space radiation is comprised of a large number of particle types and energies, which have differential ionization power from high energy protons to high charge and energy (HZE) particles and secondary neutrons produced by galactic cosmic rays (GCR). Ground based accelerators such as the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL) are used to simulate space radiation for radiobiology research and dosimetry, electronics parts, and shielding testing using mono-energetic beams for single ion species. As a tool to support research on new risk assessment models, we have developed a stochastic model of heavy ion beams and space radiation effects, the GCR Event-based Risk Model computer code (GERMcode). For radiobiological research on mixed-field space radiation, a new GCR simulator at NSRL is proposed. The NSRL-GCR simulator, which implements the rapid switching mode and the higher energy beam extraction to 1.5 GeV/u, can integrate multiple ions into a single simulation to create GCR Z-spectrum in major energy bins. After considering the GCR environment and energy limitations of NSRL, a GCR reference field is proposed after extensive simulation studies using the GERMcode. The GCR reference field is shown to reproduce the Z and LET spectra of GCR behind shielding within 20 percents accuracy compared to simulated full GCR environments behind shielding. A major challenge for space radiobiology research is to consider chronic GCR exposure of up to 3-years in relation to simulations with cell and animal models of human risks. We discuss possible approaches to map important biological time scales in experimental models using ground-based simulation with extended exposure of up to a few weeks and fractionation approaches at a GCR simulator.

  7. Mixed-field GCR Simulations for Radiobiological Research Using Ground Based Accelerators

    NASA Technical Reports Server (NTRS)

    Kim, Myung-Hee Y.; Rusek, Adam; Cucinotta, Francis A.

    2014-01-01

    Space radiation is comprised of a large number of particle types and energies, which have differential ionization power from high energy protons to high charge and energy (HZE) particles and secondary neutrons produced by galactic cosmic rays (GCR). Ground based accelerators such as the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL) are used to simulate space radiation for radiobiology research and dosimetry, electronics parts, and shielding testing using mono-energetic beams for single ion species. As a tool to support research on new risk assessment models, we have developed a stochastic model of heavy ion beams and space radiation effects, the GCR Event-based Risk Model computer code (GERMcode). For radiobiological research on mixed-field space radiation, a new GCR simulator at NSRL is proposed. The NSRL-GCR simulator, which implements the rapid switching mode and the higher energy beam extraction to 1.5 GeV/u, can integrate multiple ions into a single simulation to create GCR Z-spectrum in major energy bins. After considering the GCR environment and energy limitations of NSRL, a GCR reference field is proposed after extensive simulation studies using the GERMcode. The GCR reference field is shown to reproduce the Z and LET spectra of GCR behind shielding within 20% accuracy compared to simulated full GCR environments behind shielding. A major challenge for space radiobiology research is to consider chronic GCR exposure of up to 3-years in relation to simulations with cell and animal models of human risks. We discuss possible approaches to map important biological time scales in experimental models using ground-based simulation with extended exposure of up to a few weeks and fractionation approaches at a GCR simulator.

  8. Archive of bathymetry and backscatter data collected in 2014 nearshore Breton and Gosier Islands, Breton National Wildlife Refuge, Louisiana

    USGS Publications Warehouse

    DeWitt, Nancy T.; Fredericks, Jake J.; Flocks, James G.; Miselis, Jennifer L.; Locker, Stanley D.; Kindinger, Jack G.; Bernier, Julie C.; Kelso, Kyle W.; Reynolds, Billy J.; Wiese, Dana S.; Browning, Trevor

    2016-01-01

    As part of the Barrier Island Monitoring Project, scientists from the U.S. Geological Survey (USGS) St. Petersburg Coastal and Marine Science Center conducted nearshore geophysical surveys off Breton and Gosier Islands, Louisiana, in July and August of 2014. To assist the United States Fish and Wildlife Service (USFWS) with restoration planning efforts, the USGS was tasked with answering fundamental questions about the physical environment of the southern Chandeleur Islands, including the geology, morphology, and oceanography. Baseline data needed to answer these questions were either insufficient or missing. The USGS conducted a comprehensive geologic investigation in the summer of 2014, collecting geophysical and sedimentological data.Breton Island, located at the southern end of the Chandeleur Island chain in southeastern Louisiana, was recognized as a natural, globally significant nesting sanctuary for several bird species and was established as the Breton National Wildlife Refuge (NWR) in 1904. The areal extent of Breton Island has diminished 90 percent since 1920. Land loss is attributed to ongoing relative sea-level rise, diminished sediment supply, and storm impacts. The bird population on Breton Island has also declined over the years, most notably after Hurricane George in 1998 and after Hurricane Katrina in 2015; the latter completely submerged the island. Despite decreasing habitable acreage, migratory seabirds continue to return and nest on Breton Island. To prevent the island from being submerged in the future, and to protect, stabilize, and provide more nesting and foraging areas for the bird population, the USFWS proposed a restoration effort to rebuild Breton Island to its pre-Katrina footprint.This data series serves as an archive of processed interferometric swath and single-beam bathymetry data, and side-scan sonar data, collected in the nearshore of Breton and Gosier Islands, NWR, Louisiana. The data were collected during two USGS cruises (USGS

  9. Evaluation of the National Archives program to convert nitrate aerial photographs of the United States to a stable-base safety film.

    USGS Publications Warehouse

    Williams, R.S., Jr.; Lyons, T.R.; Ferrigno, J.G.; Quinn, M.C.

    1984-01-01

    Discusses the programme on reproducing the 1930's and early 1940's nitrate aerial photographs of large areas of the US onto stable-base safety film, and the proceedings of a February 1981 meeting at the National Archives and Records Service, General Services Administration, which discussed the programme and inspected the results of the new full-size (1:1), roll-to-roll conversions. The latter process was found to be acceptable to all current and envisaged future users of this photography.-R.House

  10. Dosimetry and radiobiological studies of automated alpha-particle irradiator.

    PubMed

    M V, Jyothish Babu; Shinde, Sanjay G; S, Sunil Kumar; Ali, Manjoor; Vasumathy, R; Kumar, Amit; Kolekar, R; Kumar, Manish; Nema, P; Bhagwat, P V; Pandey, Badri N

    2013-01-01

    Understanding the effect of alpha radiation on biological systems is an important component of radiation risk assessment and associated health consequences. However, due to the short path length of alpha radiation in the atmosphere, in vitro radiobiological experiments cannot be performed with accuracy in terms of dose and specified exposure time. The present paper describes the design and dosimetry of an automated alpha-particle irradiator named 'BARC BioAlpha', which is suitable for in vitro radiobiological studies. Compared to alpha irradiators developed in other laboratories, BARC BioAlpha has integrated computer-controlled movement of the alpha-particle source, collimator, and electronic shutter. The diaphragm blades of the electronic shutter can control the area (diameter) of irradiation without any additional shielding, which is suitable for radiobiological bystander studies. To avoid irradiation with incorrect parameters, a software interlock is provided to prevent shutter opening, unless the user-specified speed of the source and collimator are achieved. The dosimetry of the alpha irradiator using CR-39 and silicon surface barrier detectors showed that ~4 MeV energy of the alpha particle reached the cells on the irradiation dish. The alpha irradiation was also demonstrated by the evaluation of DNA double-strand breaks in human cells. In conclusion, 'BARC BioAlpha' provides a user-friendly alpha irradiation system for radiobiological experiments with a novel automation mechanism for better accuracy of dose and exposure time. PMID:24266413

  11. Tritium radiobiology research in the US DOE program

    SciTech Connect

    Carsten, A.L.

    1986-01-01

    The history of the original US Atomic Energy Commission, its replacement, the Energy Research and Development Administration, and the present Department of Energy's interest and sponsorship of tritium radiobiology is reviewed beginning in 1971 and continuing through 1986. In particular, the four remaining US Department of Energy, Division of Health and Environmental Research programs are described in some detail.

  12. Research in radiobiology. Annual report, Internal Irradiation Program

    SciTech Connect

    Miller, S.C.; Buster, D.S.

    1985-12-31

    The annual progress report for the Radiobiology Division of the University of Utah College of Medicine is presented. Summaries of twenty-four projects concerning the metabolism, dosimetry and toxicity of a variety of actinide elements in beagles or rats are given. Individual papers within this report have been separately indexed and abstracted for the data base.

  13. Solar radiation observation stations with complete listing of data archived by the National Climatic Center, Asheville, North Carolina and initial listing of data not currently archived

    NASA Technical Reports Server (NTRS)

    Carter, E. A.; Wells, R. E.; Williams, B. B.; Christensen, D. L.

    1976-01-01

    A listing is provided of organizations taking solar radiation data, the 166 stations where observations are made, the type of equipment used, the form of the recorded data, and the period of operation of each station. Included is a listing of the data from 150 solar radiation stations collected over the past 25 years and stored by the National Climatic Center.

  14. Transnational science and collaborative networks. The case of Genetics and Radiobiology in Mexico, 1950-1970.

    PubMed

    Barahona, Ana

    2015-01-01

    The transnational approach of the science and technology studies (S&TS) abandons the nation as a unit of analysis in order to understand the development of science history. It also abandons Euro-US-centred narratives in order to explain the role of international collaborative networks and the circulation of knowledge, people, artefacts and scientific practices. It is precisely under this perspective that the development of genetics and radiobiology in Mexico shall be analyzed, together with the pioneering work of the Mexican physician-turned-geneticist Alfonso León de Garay who spent two years in the Galton Laboratory in London under the supervision of Lionel Penrose. Upon his return de Garay funded the Genetics and Radiobiology Program of the National Commission of Nuclear Energy based on local needs and the aim of working beyond geographical limitations to thus facilitate the circulation of knowledge, practices and people. The three main lines of research conducted in the years after its foundation that were in line with international projects while responding to the national context were, first, cytogenetic studies of certain abnormalities, and the cytogenetics and anthropological studies of the Olympic Games held in Mexico in 1968; second, the study of the effects of radiation on hereditary material; and third, the study of population genetics in Drosophila and in Mexican indigenous groups. The program played a key role in reshaping the scientific careers of Mexican geneticists, and in transferring locally sourced research into broader networks. This case shows the importance of international collaborative networks and circulation in the constitution of national scientific elites, and also shows the national and transnational concerns that shaped local practices. PMID:26775432

  15. A new research program for ground-based space radiobiology in Europe

    NASA Astrophysics Data System (ADS)

    Durante, M.; Kraft, G.; O'Neill, P.; Reitz, G.; Sabatier, L.; Schneider, U.

    Space radiation has been long acknowledged as a potential showstopper for long duration manned interplanetary missions Our knowledge of biological effects of cosmic radiation in deep space is almost exclusively derived from ground-based accelerator experiments with heavy ions in animal or in vitro models In an effort to gain more information on space radiation risk and to develop countermeasures NASA started several years ago a Space Radiation Health Program which is currently supporting biological experiments performed at the Brookhaven National Laboratory Upton NY Accelerator-based radiobiology research in the field of space radiation research is also under way in Russia and Japan The European Space Agency ESA has recently established an ambitious exploration program AURORA and within this program it has been decided to start a space radiation research program Europe has a wide tradition in radiobiology research at accelerators generally focussing on charged-particle cancer therapy This expertise can be adapted to address the issue of space radiation risk To support research in this field in Europe ESA issued in 2005 a call for tender for a preliminary study of investigations on biological effects of space radiation IBER This study will prepare future ESA supported-activities in space radiation research by selecting the best European accelerator facilities to be targeted for cooperation and by drafting a roadmap for future research activities The roadmap will include a prioritisation of research topics and a detailed proposal

  16. Preparatory study of a ground-based space radiobiology program in Europe

    NASA Astrophysics Data System (ADS)

    Durante, M.; Kraft, G.; O'Neill, P.; Reitz, G.; Sabatier, L.; Schneider, U.

    Space radiation has long been acknowledged as a potential showstopper for long duration manned interplanetary missions. Our knowledge of biological effects of cosmic radiation in deep space is almost exclusively derived from ground-based accelerator experiments with heavy ions in animal or in vitro models. In an effort to gain more information on space radiation risk and to develop countermeasures, NASA initiated several years ago a Space Radiation Health Program, which is currently supporting biological experiments performed at the Brookhaven National Laboratory. Accelerator-based radiobiology research in the field of space radiation research is also under way in Russia and Japan. The European Space Agency (ESA) has recently established an ambitious exploration program (AURORA), and within this program it has been decided to include a space radiation research program. Europe has a long tradition in radiobiology research at accelerators, generally focussing on charged-particle cancer therapy. This expertise can be adapted to address the issue of space radiation risk. To support research in this field in Europe, ESA issued a call for tender in 2005 for a preliminary study of investigations on biological effects of space radiation (IBER). This study will provide guidance on future ESA-supported activities in space radiation research by identifying the most appropriate European accelerator facilities to be targeted for cooperation, and by drafting a roadmap for future research activities. The roadmap will include a prioritisation of research topics, and a detailed proposal for experimental campaigns for the following 5 10 years.

  17. 36 CFR 1253.7 - Regional Archives.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Regional Archives. 1253.7 Section 1253.7 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE LOCATION OF NARA FACILITIES AND HOURS OF USE § 1253.7 Regional Archives. Hours...

  18. 22 CFR 171.6 - Archival records.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Archival records. 171.6 Section 171.6 Foreign Relations DEPARTMENT OF STATE ACCESS TO INFORMATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC General Policy and Procedures § 171.6 Archival records. The Department ordinarily transfers records to the National Archives when they are...

  19. The NASA Space Radiobiology Risk Assessment Project

    NASA Astrophysics Data System (ADS)

    Cucinotta, Francis A.; Huff, Janice; Ponomarev, Artem; Patel, Zarana; Kim, Myung-Hee

    The current first phase (2006-2011) has the three major goals of: 1) optimizing the conventional cancer risk models currently used based on the double-detriment life-table and radiation quality functions; 2) the integration of biophysical models of acute radiation syndromes; and 3) the development of new systems radiation biology models of cancer processes. The first-phase also includes continued uncertainty assessment of space radiation environmental models and transport codes, and relative biological effectiveness factors (RBE) based on flight data and NSRL results, respectively. The second phase of the (2012-2016) will: 1) develop biophysical models of central nervous system risks (CNS); 2) achieve comphrensive systems biology models of cancer processes using data from proton and heavy ion studies performed at NSRL; and 3) begin to identify computational models of biological countermeasures. Goals for the third phase (2017-2021) include: 1) the development of a systems biology model of cancer risks for operational use at NASA; 2) development of models of degenerative risks, 2) quantitative models of counter-measure impacts on cancer risks; and 3) indiviudal based risk assessments. Finally, we will support a decision point to continue NSRL research in support of NASA's exploration goals beyond 2021, and create an archival of NSRL research results for continued analysis. Details on near term goals, plans for a WEB based data resource of NSRL results, and a space radiation Wikepedia are described.

  20. Dosimetry for radiobiological studies of the human hematopoietic system

    NASA Technical Reports Server (NTRS)

    Beck, W. L.; Stokes, T. R.; Lushbaugh, C. C.

    1972-01-01

    A system for estimating individual bone marrow doses in therapeutic radiation exposures of leukemia patients was studied. These measurements are used to make dose response correlations and to study the effect of dose protraction on peripheral blood cell levels. Three irradiators designed to produce a uniform field of high energy gamma radiation for total body exposures of large animals and man are also used for radiobiological studies.

  1. Radiobiological risk and single event effects during manned space flights.

    PubMed

    Bourrieau, J; Calvet, M C

    1995-01-01

    Radiation hazard during previous manned space flights was not a critical problem as seen from monitoring on board MIR and the SHUTTLE. Future Martian and Lunar missions as well as flights on inclined or high altitude orbits around the Earth can be exposed to a large radiobiological risk and critical reliability losses can be expected, due to Single Event Effects on VLSI devices. The main characteristics of these hazards and some counter-measures to be provided for are given. PMID:11540985

  2. Radioembolization of Hepatic Lesions from a Radiobiology and Dosimetric Perspective

    PubMed Central

    Cremonesi, Marta; Chiesa, Carlo; Strigari, Lidia; Ferrari, Mahila; Botta, Francesca; Guerriero, Francesco; De Cicco, Concetta; Bonomo, Guido; Orsi, Franco; Bodei, Lisa; Di Dia, Amalia; Grana, Chiara Maria; Orecchia, Roberto

    2014-01-01

    Radioembolization (RE) of liver cancer with 90Y-microspheres has been applied in the last two decades with notable responses and acceptable toxicity. Two types of microspheres are available, glass and resin, the main difference being the activity/sphere. Generally, administered activities are established by empirical methods and differ for the two types. Treatment planning based on dosimetry is a prerogative of few centers, but has notably gained interest, with evidence of predictive power of dosimetry on toxicity, lesion response, and overall survival (OS). Radiobiological correlations between absorbed doses and toxicity to organs at risk, and tumor response, have been obtained in many clinical studies. Dosimetry methods have evolved from the macroscopic approach at the organ level to voxel analysis, providing absorbed dose spatial distributions and dose–volume histograms (DVH). The well-known effects of the external beam radiation therapy (EBRT), such as the volume effect, underlying disease influence, cumulative damage in parallel organs, and different tolerability of re-treatment, have been observed also in RE, identifying in EBRT a foremost reference to compare with. The radiobiological models – normal tissue complication probability and tumor control probability – and/or the style (DVH concepts) used in EBRT are introduced in RE. Moreover, attention has been paid to the intrinsic different activity distribution of resin and glass spheres at the microscopic scale, with dosimetric and radiobiological consequences. Dedicated studies and mathematical models have developed this issue and explain some clinical evidences, e.g., the shift of dose to higher toxicity thresholds using glass as compared to resin spheres. This paper offers a comprehensive review of the literature incident to dosimetry and radiobiological issues in RE, with the aim to summarize the results and to identify the most useful methods and information that should accompany future studies

  3. New challenges in high-energy particle radiobiology.

    PubMed

    Durante, M

    2014-03-01

    Densely ionizing radiation has always been a main topic in radiobiology. In fact, α-particles and neutrons are sources of radiation exposure for the general population and workers in nuclear power plants. More recently, high-energy protons and heavy ions attracted a large interest for two applications: hadrontherapy in oncology and space radiation protection in manned space missions. For many years, studies concentrated on measurements of the relative biological effectiveness (RBE) of the energetic particles for different end points, especially cell killing (for radiotherapy) and carcinogenesis (for late effects). Although more recently, it has been shown that densely ionizing radiation elicits signalling pathways quite distinct from those involved in the cell and tissue response to photons. The response of the microenvironment to charged particles is therefore under scrutiny, and both the damage in the target and non-target tissues are relevant. The role of individual susceptibility in therapy and risk is obviously a major topic in radiation research in general, and for ion radiobiology as well. Particle radiobiology is therefore now entering into a new phase, where beyond RBE, the tissue response is considered. These results may open new applications for both cancer therapy and protection in deep space. PMID:24198199

  4. (Radio)Biological Optimization of External-Beam Radiotherapy

    PubMed Central

    Nahum, Alan E.; Uzan, Julien

    2012-01-01

    “Biological optimization” (BIOP) means planning treatments using (radio)biological criteria and models, that is, tumour control probability and normal-tissue complication probability. Four different levels of BIOP are identified: Level I is “isotoxic” individualization of prescription dose Dpresc at fixed fraction number. Dpresc is varied to keep the NTCP of the organ at risk constant. Significant improvements in local control are expected for non-small-cell lung tumours. Level II involves the determination of an individualized isotoxic combination of Dpresc and fractionation scheme. This approach is appropriate for “parallel” OARs (lung, parotids). Examples are given using our BioSuite software. Hypofractionated SABR for early-stage NSCLC is effectively Level-II BIOP. Level-III BIOP uses radiobiological functions as part of the inverse planning of IMRT, for example, maximizing TCP whilst not exceeding a given NTCP. This results in non-uniform target doses. The NTCP model parameters (reflecting tissue “architecture”) drive the optimizer to emphasize different regions of the DVH, for example, penalising high doses for quasi-serial OARs such as rectum. Level-IV BIOP adds functional imaging information, for example, hypoxia or clonogen location, to Level III; examples are given of our prostate “dose painting” protocol, BioProp. The limitations of and uncertainties inherent in the radiobiological models are emphasized. PMID:23251227

  5. New challenges in high-energy particle radiobiology

    PubMed Central

    2014-01-01

    Densely ionizing radiation has always been a main topic in radiobiology. In fact, α-particles and neutrons are sources of radiation exposure for the general population and workers in nuclear power plants. More recently, high-energy protons and heavy ions attracted a large interest for two applications: hadrontherapy in oncology and space radiation protection in manned space missions. For many years, studies concentrated on measurements of the relative biological effectiveness (RBE) of the energetic particles for different end points, especially cell killing (for radiotherapy) and carcinogenesis (for late effects). Although more recently, it has been shown that densely ionizing radiation elicits signalling pathways quite distinct from those involved in the cell and tissue response to photons. The response of the microenvironment to charged particles is therefore under scrutiny, and both the damage in the target and non-target tissues are relevant. The role of individual susceptibility in therapy and risk is obviously a major topic in radiation research in general, and for ion radiobiology as well. Particle radiobiology is therefore now entering into a new phase, where beyond RBE, the tissue response is considered. These results may open new applications for both cancer therapy and protection in deep space. PMID:24198199

  6. Quantitative modeling of chronic myeloid leukemia: insights from radiobiology

    PubMed Central

    Radivoyevitch, Tomas; Hlatky, Lynn; Landaw, Julian

    2012-01-01

    Mathematical models of chronic myeloid leukemia (CML) cell population dynamics are being developed to improve CML understanding and treatment. We review such models in light of relevant findings from radiobiology, emphasizing 3 points. First, the CML models almost all assert that the latency time, from CML initiation to diagnosis, is at most ∼ 10 years. Meanwhile, current radiobiologic estimates, based on Japanese atomic bomb survivor data, indicate a substantially higher maximum, suggesting longer-term relapses and extra resistance mutations. Second, different CML models assume different numbers, between 400 and 106, of normal HSCs. Radiobiologic estimates favor values > 106 for the number of normal cells (often assumed to be the HSCs) that are at risk for a CML-initiating BCR-ABL translocation. Moreover, there is some evidence for an HSC dead-band hypothesis, consistent with HSC numbers being very different across different healthy adults. Third, radiobiologists have found that sporadic (background, age-driven) chromosome translocation incidence increases with age during adulthood. BCR-ABL translocation incidence increasing with age would provide a hitherto underanalyzed contribution to observed background adult-onset CML incidence acceleration with age, and would cast some doubt on stage-number inferences from multistage carcinogenesis models in general. PMID:22353999

  7. In vitro irradiation station for broad beam radiobiological experiments

    NASA Astrophysics Data System (ADS)

    Wéra, A.-C.; Riquier, H.; Heuskin, A.-C.; Michiels, C.; Lucas, S.

    2011-12-01

    The study of the interaction of charged particles with living matter is of prime importance to the fields of radiotherapy, radioprotection and space radiobiology. Particle accelerators and their associated equipment are proven to be helpful tools in performing basic science in all these fields. Indeed, they can accelerate virtually any ions to a given energy and flux and let them interact with living matter either in vivo or in vitro. In this context, the University of Namur has developed a broad beam in vitro irradiation station for use in radiobiological experiments. Cells are handled in GLP conditions and can be irradiated at various fluxes with ions ranging from hydrogen to carbon. The station is mounted on a 2 MV tandem accelerator, and the energy range can be set up in the linear energy transfer (LET) ranges that are useful for radiobiological experiments. This paper describes the current status of the hardware that has been developed, and presents results related to its performance in term of dose-rate, energy range and beam uniformity for protons, alpha particles and carbon ions. The results of clonogenic assays of A549 lung adenocarcinoma cells irradiated with protons and alpha particles are also presented and compared with literature.

  8. Quantitative modeling of chronic myeloid leukemia: insights from radiobiology.

    PubMed

    Radivoyevitch, Tomas; Hlatky, Lynn; Landaw, Julian; Sachs, Rainer K

    2012-05-10

    Mathematical models of chronic myeloid leukemia (CML) cell population dynamics are being developed to improve CML understanding and treatment. We review such models in light of relevant findings from radiobiology, emphasizing 3 points. First, the CML models almost all assert that the latency time, from CML initiation to diagnosis, is at most ∼10 years. Meanwhile, current radiobiologic estimates, based on Japanese atomic bomb survivor data, indicate a substantially higher maximum, suggesting longer-term relapses and extra resistance mutations. Second, different CML models assume different numbers, between 400 and 10(6), of normal HSCs. Radiobiologic estimates favor values>10(6) for the number of normal cells (often assumed to be the HSCs) that are at risk for a CML-initiating BCR-ABL translocation. Moreover, there is some evidence for an HSC dead-band hypothesis, consistent with HSC numbers being very different across different healthy adults. Third, radiobiologists have found that sporadic (background, age-driven) chromosome translocation incidence increases with age during adulthood. BCR-ABL translocation incidence increasing with age would provide a hitherto underanalyzed contribution to observed background adult-onset CML incidence acceleration with age, and would cast some doubt on stage-number inferences from multistage carcinogenesis models in general. PMID:22353999

  9. Surface Model and Tomographic Archive of Fossil Primate and Other Mammal Holotype and Paratype Specimens of the Ditsong National Museum of Natural History, Pretoria, South Africa

    PubMed Central

    Adams, Justin W.; Olah, Angela; McCurry, Matthew R.; Potze, Stephany

    2015-01-01

    Nearly a century of paleontological excavation and analysis from the cave deposits of the Cradle of Humankind UNESCO World Heritage Site in northeastern South Africa underlies much of our understanding of the evolutionary history of hominins, other primates and other mammal lineages in the late Pliocene and early Pleistocene of Africa. As one of few designated fossil repositories, the Plio-Pleistocene Palaeontology Section of the Ditsong National Museum of Natural History (DNMNH; the former Transvaal Museum) curates much of the mammalian faunas recovered from the fossil-rich deposits of major South African hominin-bearing localities, including the holotype and paratype specimens of many primate, carnivore, and other mammal species (Orders Primates, Carnivora, Artiodactyla, Eulipotyphla, Hyracoidea, Lagomorpha, Perissodactyla, and Proboscidea). Here we describe an open-access digital archive of high-resolution, full-color three-dimensional (3D) surface meshes of all 89 non-hominin holotype, paratype and significant mammalian specimens curated in the Plio-Pleistocene Section vault. Surface meshes were generated using a commercial surface scanner (Artec Spider, Artec Group, Luxembourg), are provided in formats that can be opened in both open-source and commercial software, and can be readily downloaded either via an online data repository (MorphoSource) or via direct request from the DNMNH. In addition to providing surface meshes for each specimen, we also provide tomographic data (both computerized tomography [CT] and microfocus [microCT]) for a subset of these fossil specimens. This archive of the DNMNH Plio-Pleistocene collections represents the first research-quality 3D datasets of African mammal fossils to be made openly available. This simultaneously provides the paleontological community with essential baseline information (e.g., updated listing and 3D record of specimens in their current state of preservation) and serves as a single resource of high

  10. 36 CFR 1254.86 - May I use a personal paper-to-paper copier at the National Archives at College Park?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND DONATED HISTORICAL MATERIALS Copying Archival Materials Rules Relating to Using Copying Equipment... must be trained by NARA staff on the proper methods for handling and copying archival documents....

  11. Archiving Derrida

    ERIC Educational Resources Information Center

    Morris, Marla

    2003-01-01

    Derrida's archive, broadly speaking, is brilliantly mad, for he digs exegetically into the most difficult textual material and combines the most unlikely texts--from Socrates to Freud, from postcards to encyclopedias, from madness(es) to the archive, from primal scenes to death. In this paper, the author would like to do a brief study of the…

  12. Validation of mega composite sampling and nationwide mass inventories for 26 previously unmonitored contaminants in archived biosolids from the U.S National Biosolids Repository

    PubMed Central

    Chari, Bipin P.; Halden, Rolf U.

    2012-01-01

    In the present study, archived U.S biosolids from the 2001 Environmental Protection Agency (EPA) National Sewage Sludge Survey were analyzed with an expanded U.S EPA Method 1694, to determine the occurrence of 26 previously unmonitored pharmaceuticals and personal care products (PPCPs) among a total of 120 analytes. The study further served to examine the reproducibility of a mega-composite approach for creating chemical mass inventories in biosolids based on pooled samples from wastewater treatment plants (WWTPs) nationwide. Five mega-composites reflecting 94 WWTPs in 32 states and the District of Columbia were constructed from archived biosolids and analyzed by LC/ESI-MS/MS using a newly introduced analytical method expanding upon U.S EPA Method 1694. In addition, soil-biosolids mixtures from a mesocosm setup were analyzed to experimentally determine the half-lives of biosolids-borne compounds applied on U.S land. Among 59 analytes detected, 33 had been reported previously, whereas 26 are reported in biosolids for the first time, at levels ranging from 1.65 to 673 μg kg−1 dry weight. Newly recognized biosolids constituents were identified as Ca2+ channel blockers, antidepressants, diuretics, β-blockers and analgesics. Using a mass balance approach, the total loading of these 26 pharmaceuticals to U.S soils from biosolids land application was estimated at 5–15 tons year−1. Past and present datasets for 30 pharmaceuticals and personal care products (PPCPs) were determined to be statistically indistinguishable (paired t-test; p = 0.01). This study expands the list of PPCPs reported in U.S biosolids, provides the first estimates of nationwide release rates to and environmental half-lives in U.S agricultural soils, and confirms the utility of using mega-composite sampling for economical tracking of chemical inventories in biosolids on a national scale. PMID:22789759

  13. Public Discourse on HIV and AIDS: An Archival Analysis of National Newspaper Reporting in Uganda, 1996-2011

    ERIC Educational Resources Information Center

    Lagone, Elizabeth; Mathur, Sanyukta; Nakyanjo, Neema; Nalugoda, Fred; Santelli, John

    2014-01-01

    Uganda is recognised as an early success story in the HIV epidemic at least in part due to an open and vigorous national dialogue about HIV prevention. This study examined the national discourse about HIV, AIDS, and young people in New Vision, Uganda's leading national newspaper between 1996 and 2011, building from a previous archival…

  14. Manned Mars mission radiation environment and radiobiology

    NASA Technical Reports Server (NTRS)

    Nachtwey, D. S.

    1986-01-01

    Potential radiation hazards to crew members on manned Mars missions are discussed. It deals briefly with radiation sources and environments likely to be encountered during various phases of such missions, providing quantitative estimates of these environments. Also provided are quantitative data and discussions on the implications of such radiation on the human body. Various sorts of protective measures are suggested. Recent re-evaluation of allowable dose limits by the National Council of Radiation Protection is discussed, and potential implications from such activity are assessed.

  15. Toolkit for determination of dose-response relations, validation of radiobiological parameters and treatment plan optimization based on radiobiological measures.

    PubMed

    Mavroidis, Panayiotis; Tzikas, Athanasios; Papanikolaou, Nikos; Lind, Bengt K

    2010-10-01

    Accurately determined dose-response relations of the different tumors and normal tissues should be estimated and used in the clinic. The aim of this study is to demonstrate developed tools that are necessary for determining the dose-response parameters of tumors and normal tissues, for clinically verifying already published parameter sets using local patient materials and for making use of all this information in the optimization and comparison of different treatment plans and radiation techniques. One of the software modules (the Parameter Determination Module) is designed to determine the dose-response parameters of tumors and normal tissues. This is accomplished by performing a maximum likelihood fitting to calculate the best estimates and confidence intervals of the parameters used by different radiobiological models. Another module of this software (the Parameter Validation Module) concerns the validation and compatibility of external or reported dose-response parameters describing tumor control and normal tissue complications. This is accomplished by associating the expected response rates, which are calculated using different models and published parameter sets, with the clinical follow-up records of the local patient population. Finally, the last module of the software (the Radiobiological Plan Evaluation Module) is used for estimating and optimizing the effectiveness a treatment plan in terms of complication-free tumor control, P(+). The use of the Parameter Determination Module is demonstrated by deriving the dose-response relation of proximal esophagus from head and neck cancer radiotherapy. The application of the Parameter Validation Module is illustrated by verifying the clinical compatibility of those dose-response parameters with the examined treatment methodologies. The Radiobiological Plan Evaluation Module is demonstrated by evaluating and optimizing the effectiveness of head and neck cancer treatment plans. The results of the radiobiological

  16. 75 FR 32229 - National Declassification Center (NDC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... From the Federal Register Online via the Government Publishing Office NATIONAL ARCHIVES AND RECORDS ADMINISTRATION National Declassification Center (NDC) AGENCY: National Archives and Records..., Classified National Security Information, announcement is made for the National Declassification Center...

  17. The New Radiobiology: Returning to Our Roots

    PubMed Central

    Ulsh, Brant A.

    2012-01-01

    In 2005, two expert advisory bodies examined the evidence on the effects of low doses of ionizing radiation. The U.S. National Research Council concluded that current scientific evidence is consistent with the linear no-threshold dose-response relationship (NRCNA 2005) while the French National Academies of Science and Medicine concluded the opposite (Aurengo et al. 2005). These contradictory conclusions may stem in part from an emphasis on epidemiological data (a “top down” approach) versus an emphasis on biological mechanisms (a “bottom up” approach). In this paper, the strengths and limitations of the top down and bottom up approaches are discussed, and proposals for strengthening and reconciling them are suggested. The past seven years since these two reports were published have yielded increasing evidence of nonlinear responses of biological systems to low radiation doses delivered at low dose-rates. This growing body of evidence is casting ever more doubt on the extrapolation of risks observed at high doses and dose-rates to estimate risks associated with typical environmental and occupational exposures. This paper compares current evidence on low dose, low dose-rate effects against objective criteria of causation. Finally, some questions for a post-LNT world are posed. PMID:23304107

  18. 76 FR 52991 - Renewal of Advisory Committee on Electronic Records Archives

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... RECORDS ADMINISTRATION Renewal of Advisory Committee on Electronic Records Archives AGENCY: National... Administration's (NARA) Advisory Committee on Electronic Records Archives. In accordance with Office of... Electronic Records Archives in NARA's ceiling of discretionary advisory committees. FOR FURTHER...

  19. 36 CFR 1256.20 - May I obtain access to Federal archival records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Federal archival records? 1256.20 Section 1256.20 Parks, Forests, and Public Property NATIONAL ARCHIVES... MATERIALS Access to Federal Archival Records § 1256.20 May I obtain access to Federal archival records? (a) Most Federal archival records are open for research without submitting a Freedom of Information...

  20. Application of SSNTDs in radiobiological investigations aboard recoverable satellites.

    PubMed

    Huang, R Q; Gu, R Q; Li, Q

    1997-01-01

    In recent years some Biostack experiments including a wide spectrum of biological objects have been devoted to study of the radiobiological effects on dry seeds aboard recoverable satellites. Some impressive phenomena have been observed. Clearly, the large amount of energy deposited by the highly ionizing heavy nuclei of cosmic rays is the principal reason for the induced aberrations of the chromosomes of wheat root tip cells. A methodical description of the experimental arrangement and procedure of handling and evaluation of given. The preliminary physical and biological results from the experimental "wheat seeds" are presented. PMID:11541794

  1. Relevance of radiobiological concepts in radionuclide therapy of cancer.

    PubMed

    Kumar, Chandan; Shetake, Neena; Desai, Sejal; Kumar, Amit; Samuel, Grace; Pandey, Badri N

    2016-04-01

    Purpose Radionuclide therapy (RNT) is a rapidly growing area of clinical nuclear medicine, wherein radionuclides are employed to deliver cytotoxic dose of radiation to the diseased cells/tissues. During RNT, radionuclides are either directly administered or delivered through biomolecules targeting the diseased site. RNT has been clinically used for diverse range of diseases including cancer, which is the focus of the review. Conclusions The major emphasis in RNT has so far been given towards developing peptides/antibodies and other molecules to conjugate a variety of therapeutic radioisotopes for improved targeting/delivery of radiation dose to the tumor cells. Despite that, many of the RNT approaches have not achieved their desired therapeutic success probably due to poor knowledge about complex and dynamic (i) fate of radiolabeled molecules; (ii) radiation dose delivered; (iii) cellular heterogeneity in tumor mass; and (iv) cellular radiobiological response. Based on understanding gathered during recent years, it may be stated that besides the absorbed dose, the net radiobiological response of tumor/normal cells also determines the clinical response of radiotherapeutic modalities including RNT. The radiosensitivity of tumor/normal cells is governed by radiobiological phenomenon such as radiation-induced bystander effect, genomic instability, adaptive response and low dose hyper-radiosensitivity. These concepts have been well investigated in the context of external beam radiotherapy, but their clinical implications during RNT have received meagre attention. In this direction, a few studies performed using in vitro and in vivo models envisage the possibilities of exploiting the radiobiological knowledge for improved therapeutic outcome of RNT. Abbreviations ALL Acute Lymphoid Leukaemia AML Acute Myeloid Leukaemia CEA Carcinoembryonic Antigen CD Cluster of Differentiation CLL Chronic Lymphocytic Leukaemia CNS Central Nervous System CPP Cell Penetrating Peptide, DC

  2. Strike Up the Score: Deriving Searchable and Playable Digital Formats from Sheet Music; Smart Objects and Open Archives; Building the Archives of the Future: Advanced in Preserving Electronic Records at the National Archives and Records Administration; From the Digitized to the Digital Library.

    ERIC Educational Resources Information Center

    Choudhury, G. Sayeed; DiLauro, Tim; Droettboom, Michael; Fujinaga, Ichiro; MacMillan, Karl; Nelson, Michael L.; Maly, Kurt; Thibodeau, Kenneth; Thaller, Manfred

    2001-01-01

    These articles describe the experiences of the Johns Hopkins University library in digitizing their collection of sheet music; motivation for buckets, Smart Object, Dumb Archive (SODA) and the Open Archives Initiative (OAI), and initial experiences using them in digital library (DL) testbeds; requirements for archival institutions, the National…

  3. Hypofractionation in prostate cancer: radiobiological basis and clinical appliance.

    PubMed

    Mangoni, M; Desideri, I; Detti, B; Bonomo, P; Greto, D; Paiar, F; Simontacchi, G; Meattini, I; Scoccianti, S; Masoni, T; Ciabatti, C; Turkaj, A; Serni, S; Minervini, A; Gacci, M; Carini, M; Livi, L

    2014-01-01

    External beam radiation therapy with conventional fractionation to a total dose of 76-80 Gy represents the most adopted treatment modality for prostate cancer. Dose escalation in this setting has been demonstrated to improve biochemical control with acceptable toxicity using contemporary radiotherapy techniques. Hypofractionated radiotherapy and stereotactic body radiation therapy have gained an increasing interest in recent years and they have the potential to become the standard of care even if long-term data about their efficacy and safety are not well established. Strong radiobiological basis supports the use of high dose for fraction in prostate cancer, due to the demonstrated exceptionally low values of α / β . Clinical experiences with hypofractionated and stereotactic radiotherapy (with an adequate biologically equivalent dose) demonstrated good tolerance, a PSA control comparable to conventional fractionation, and the advantage of shorter time period of treatment. This paper reviews the radiobiological findings that have led to the increasing use of hypofractionation in the management of prostate cancer and briefly analyzes the clinical experience in this setting. PMID:24999475

  4. Hypofractionation in Prostate Cancer: Radiobiological Basis and Clinical Appliance

    PubMed Central

    Mangoni, M.; Desideri, I.; Detti, B.; Bonomo, P.; Greto, D.; Paiar, F.; Simontacchi, G.; Meattini, I.; Scoccianti, S.; Masoni, T.; Ciabatti, C.; Turkaj, A.; Serni, S.; Minervini, A.; Gacci, M.; Carini, M.; Livi, L.

    2014-01-01

    External beam radiation therapy with conventional fractionation to a total dose of 76–80 Gy represents the most adopted treatment modality for prostate cancer. Dose escalation in this setting has been demonstrated to improve biochemical control with acceptable toxicity using contemporary radiotherapy techniques. Hypofractionated radiotherapy and stereotactic body radiation therapy have gained an increasing interest in recent years and they have the potential to become the standard of care even if long-term data about their efficacy and safety are not well established. Strong radiobiological basis supports the use of high dose for fraction in prostate cancer, due to the demonstrated exceptionally low values of α/β. Clinical experiences with hypofractionated and stereotactic radiotherapy (with an adequate biologically equivalent dose) demonstrated good tolerance, a PSA control comparable to conventional fractionation, and the advantage of shorter time period of treatment. This paper reviews the radiobiological findings that have led to the increasing use of hypofractionation in the management of prostate cancer and briefly analyzes the clinical experience in this setting. PMID:24999475

  5. Cell irradiation setup and dosimetry for radiobiological studies at ELBE

    NASA Astrophysics Data System (ADS)

    Zeil, K.; Beyreuther, E.; Lessmann, E.; Wagner, W.; Pawelke, J.

    2009-07-01

    The radiation source ELBE delivers different types of secondary radiation, which is used for cell irradiation studies in radiobiological research. Thereby an important issue is the determination of the biological effectiveness of photon radiation as a function of photon energy by using low-energetic, monochromatic channeling radiation (10-100 keV) and high-energetic bremsstrahlung (up to 40 MV). Radiobiological studies at the research facility ELBE demand special technical and dosimetric prerequisites. Therefore, a cell irradiation system (CIS) has been designed, constructed and installed at the beam line. The CIS allows automatic irradiation of a larger cell sample number and the compensation of spatial inhomogeneity of the dose distribution within the beam spot. The recently introduced GafChromic ® EBT radiochromic film model has been used to verify the cell irradiation dose deposition achieving a dose uncertainty of <5%. Both, the installed cell irradiation system and the developed dosimetric procedure based on the use of the EBT film have been experimentally tested at ELBE. The biological effectiveness of 34 MV bremsstrahlung with respect to 200 kV X-rays from a conventional X-ray tube has been determined. An RBE value of 0.75 has been measured in good agreement with literature.

  6. Influence of oxygen on the chemical stage of radiobiological mechanism

    NASA Astrophysics Data System (ADS)

    Barilla, Jiří; Lokajíček, Miloš V.; Pisaková, Hana; Simr, Pavel

    2016-07-01

    The simulation of the chemical stage of radiobiological mechanism may be very helpful in studying the radiobiological effect of ionizing radiation when the water radical clusters formed by the densely ionizing ends of primary or secondary charged particle may form DSBs damaging DNA molecules in living cells. It is possible to study not only the efficiency of individual radicals but also the influence of other species or radiomodifiers (mainly oxygen) being present in water medium during irradiation. The mathematical model based on Continuous Petri nets (proposed by us recently) will be described. It makes it possible to analyze two main processes running at the same time: chemical radical reactions and the diffusion of radical clusters formed during energy transfer. One may study the time change of radical concentrations due to the chemical reactions running during diffusion process. Some orientation results concerning the efficiency of individual radicals in DSB formation (in the case of Co60 radiation) will be presented; the influence of oxygen present in water medium during irradiation will be shown, too.

  7. Detailed characterization of the 1087 MeV/nucleon iron-56 beam used for radiobiology at the alternating gradient synchrotron

    NASA Technical Reports Server (NTRS)

    Zeitlin, C.; Heilbronn, L.; Miller, J.

    1998-01-01

    We report beam characterization and dosimetric measurements made using a 56Fe beam extracted from the Brookhaven National Laboratory Alternating Gradient Synchrotron (AGS) with a kinetic energy of 1087 MeV/nucleon. The measurements reveal that the depth-dose distribution of this beam differs significantly from that obtained with a 600 MeV/nucleon iron beam used in several earlier radiobiology experiments at the Lawrence Berkeley National Laboratory's BEVALAC. We present detailed measurements of beam parameters relevant for radiobiology, including track- and dose-averaged linear energy transfer (LET), fragment composition and LET spectra measured behind sample holders used in irradiations of biological samples. We also report measurements of fluence behind three depths (1.94, 4.68 and 9.35 g cm(-2)) of polyethylene targets with the 1087 MeV/nucleon beam, and behind 1.94 g cm(-2) of polyethylene with a 610 MeV/nucleon beam delivered by the AGS. These results are compared to earlier measurements with the 600 MeV/nucleon beam at the BEVALAC.

  8. Radiation Embrittlement Archive Project

    SciTech Connect

    Klasky, Hilda B; Bass, Bennett Richard; Williams, Paul T; Phillips, Rick; Erickson, Marjorie A; Kirk, Mark T; Stevens, Gary L

    2013-01-01

    The Radiation Embrittlement Archive Project (REAP), which is being conducted by the Probabilistic Integrity Safety Assessment (PISA) Program at Oak Ridge National Laboratory under funding from the U.S. Nuclear Regulatory Commission s (NRC) Office of Nuclear Regulatory Research, aims to provide an archival source of information about the effect of neutron radiation on the properties of reactor pressure vessel (RPV) steels. Specifically, this project is an effort to create an Internet-accessible RPV steel embrittlement database. The project s website, https://reap.ornl.gov, provides information in two forms: (1) a document archive with surveillance capsule(s) reports and related technical reports, in PDF format, for the 104 commercial nuclear power plants (NPPs) in the United States, with similar reports from other countries; and (2) a relational database archive with detailed information extracted from the reports. The REAP project focuses on data collected from surveillance capsule programs for light-water moderated, nuclear power reactor vessels operated in the United States, including data on Charpy V-notch energy testing results, tensile properties, composition, exposure temperatures, neutron flux (rate of irradiation damage), and fluence, (Fast Neutron Fluence a cumulative measure of irradiation for E>1 MeV). Additionally, REAP contains data from surveillance programs conducted in other countries. REAP is presently being extended to focus on embrittlement data analysis, as well. This paper summarizes the current status of the REAP database and highlights opportunities to access the data and to participate in the project.

  9. A Survey of Mesenchyme-related Tumors of the Rat Kidney in the National Toxicology Program Archives, with Particular Reference to Renal Mesenchymal Tumor.

    PubMed

    Hard, Gordon C; Seely, John Curtis; Betz, Laura J

    2016-08-01

    In order to harmonize diagnostic terminology, confirm diagnostic criteria, and describe aspects of tumor biology characteristic of different tumor types, a total of 165 cases of mesenchyme-related tumors and nephroblastomas of the rat kidney were reexamined from the National Toxicology Program (NTP) Archives. This survey demonstrated that renal mesenchymal tumor (RMT) was the most common spontaneous nonepithelial tumor in the rat kidney, also occurring more frequently in the NTP studies than nephroblastoma. Renal sarcoma was a distinct but very rare tumor entity, representing a malignant, monomorphous population of densely crowded, fibroblast-like cells, in which, unlike RMT, preexisting tubules did not persist. Nephroblastoma was characterized by early death of affected animals, suggesting an embryonal origin for this tumor type. Male and female rats were equally disposed to developing RMT, but most of the cases of nephroblastoma occurred in female rats and liposarcoma occurred mostly in male rats. This survey confirmed discrete histopathological and biological differences between the mesenchyme-related renal tumor types and between RMT and nephroblastoma. Statistical analysis also demonstrated a lack of any relationship of these renal tumor types to test article administration in the NTP data bank. PMID:27169591

  10. National Archive of Marine Seismic Surveys (NAMSS): Status Report on U.S. Geological Survey Program Providing Access to Proprietary Data

    NASA Astrophysics Data System (ADS)

    Hart, P. E.; Childs, J. R.

    2005-05-01

    During the last four decades, hundreds of thousands of line kilometers of 2D marine seismic reflection data have been collected by the hydrocarbon exploration industry within the United States Exclusive Economic Zone. The commercial value of much of these data has decreased significantly because of drilling moratoria and new technology such as 3D acquisition. However, these data still have tremendous value for scientific research and education purposes. The U.S. Geological Survey has recently made agreements with two commercial owners of large data holdings to transfer to the public domain over 250,000 line kilometers of marine data from off the eastern, western, and Alaskan coasts of the United States. In order to provide access to the data, the USGS has developed the National Archive of Marine Seismic Surveys (NAMSS) program. For a small fraction of the money that would be required to collect new data, work is underway to organize and recover digital data currently stored on tens of thousands of 9-track tapes. Even where new data collection efforts could be funded, current environmental restrictions on marine seismic exploration could preclude operations. The NAMSS web site at http://walrus.wr.usgs.gov/NAMSS/ has trackline maps of surveys that are now or will soon be available for downloading in SEG-Y format. As more owners and users become aware of this new data resource, it is hoped that additional partners in will join this data rescue effort.

  11. Studies in the radiobiology of osteoradionecrosis and their clinical significance

    SciTech Connect

    Marx, R.E.; Johnson, R.P.

    1987-10-01

    The radiobiology of osteoradionecrosis is a complex of cellular death and cellular functional impairments from radiation energy transfers. Four studies of irradiated patients and a data base from 536 patients with osteoradionecrosis revealed separate pathophysiologic conditions for osteoradionecrosis induced by early trauma, osteoradionecrosis induced by late trauma, and spontaneous osteoradionecrosis. A large body of data suggested useful clinical guidelines for the management of irradiated patients. The guidelines, in part, include a recommendation for deferring radiation treatment for 21 days after tissue wounding, if possible; a relative contraindication to wounding tissue during a radiation course; a recommendation for the use of hyperbaric oxygen before wounding; and a strong recommendation to provide comprehensive dental care to the irradiated patient.

  12. 36 CFR 1275.24 - Archival processing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Archival processing. 1275.24 Section 1275.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NIXON PRESIDENTIAL MATERIALS PRESERVATION AND PROTECTION OF AND ACCESS TO THE PRESIDENTIAL HISTORICAL MATERIALS OF THE NIXON ADMINISTRATION...

  13. 36 CFR 1275.24 - Archival processing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Archival processing. 1275.24 Section 1275.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NIXON PRESIDENTIAL MATERIALS PRESERVATION AND PROTECTION OF AND ACCESS TO THE PRESIDENTIAL HISTORICAL MATERIALS OF THE NIXON ADMINISTRATION...

  14. 36 CFR 1275.24 - Archival processing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Archival processing. 1275.24 Section 1275.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NIXON PRESIDENTIAL MATERIALS PRESERVATION AND PROTECTION OF AND ACCESS TO THE PRESIDENTIAL HISTORICAL MATERIALS OF THE NIXON ADMINISTRATION...

  15. 36 CFR 1275.24 - Archival processing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Archival processing. 1275.24 Section 1275.24 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NIXON PRESIDENTIAL MATERIALS PRESERVATION AND PROTECTION OF AND ACCESS TO THE PRESIDENTIAL HISTORICAL MATERIALS OF THE NIXON ADMINISTRATION...

  16. Guide to the Seattle Archives Branch.

    ERIC Educational Resources Information Center

    Hobbs, Richard, Comp.

    The guide presents an overview of the textual and microfilmed records located at the Seattle Branch of the National Archives of the United States. Established in 1969, the Seattle Archives Branch is one of 11 branches which preserve and make available for research those U.S. Government records of permanent value created and maintained by Federal…

  17. Guide to the Archives of International Organizations. Part II.

    ERIC Educational Resources Information Center

    Walne, Peter, Comp.

    This compilation forms Part II of the guide according to the plan conceived by a working party of the Section of Archivists of International Organisations of the International Council on Archives in 1974-1975. The directory provides access to national and other archive and manuscript repositories that maintain the archives of international…

  18. Draft Model Law on Archives: Description and Text.

    ERIC Educational Resources Information Center

    Carbone, Salvatore; Gueze, Raoul

    A model law on archives which was prepared for the United Nations Educational, Scientific, and Cultural Organization (UNESCO) by the International Council on Archives is presented. The aim of the law is to help countries in varying stages of development to construct legal guidelines for archival use which are in line with the exigencies of modern…

  19. Digital Archival Image Collections: Who Are the Users?

    ERIC Educational Resources Information Center

    Herold, Irene M. H.

    2010-01-01

    Archival digital image collections are a relatively new phenomenon in college library archives. Digitizing archival image collections may make them accessible to users worldwide. There has been no study to explore whether collections on the Internet lead to users who are beyond the institution or a comparison of users to a national or…

  20. [California State Archives.

    ERIC Educational Resources Information Center

    Rea, Jay W.

    The first paper on the California State Archives treats the administrative status, legal basis of the archives program, and organization of the archives program. The problem areas in this States' archival program are discussed at length. The second paper gives a crude sketch of the legal and administrative history of the California State Archives,…

  1. WE-E-BRE-04: Dual Focal Spot Dose Painting for Precision Preclinical Radiobiological Investigations

    SciTech Connect

    Stewart, J; Lindsay, P; Jaffray, D

    2014-06-15

    Purpose: Recent progress in small animal radiotherapy systems has provided the foundation for delivering the heterogeneous, millimeter scale dose distributions demanded by preclinical radiobiology investigations. Despite advances in preclinical dose planning, delivery of highly heterogeneous dose distributions is constrained by the fixed collimation systems and large x-ray focal spot common in small animal radiotherapy systems. This work proposes a dual focal spot dose optimization and delivery method with a large x-ray focal spot used to deliver homogeneous dose regions and a small focal spot to paint spatially heterogeneous dose regions. Methods: Two-dimensional dose kernels were measured for a 1 mm circular collimator with radiochromic film at 10 mm depth in a solid water phantom for the small and large x-ray focal spots on a recently developed small animal microirradiator. These kernels were used in an optimization framework which segmented a desired dose distribution into low- and high-spatial frequency regions for delivery by the large and small focal spot, respectively. For each region, the method determined an optimal set of stage positions and beam-on times. The method was demonstrated by optimizing a bullseye pattern consisting of 0.75 mm radius circular target and 0.5 and 1.0 mm wide rings alternating between 0 and 2 Gy. Results: Compared to a large focal spot technique, the dual focal spot technique improved the optimized dose distribution: 69.2% of the optimized dose was within 0.5 Gy of the intended dose for the large focal spot, compared to 80.6% for the dual focal spot method. The dual focal spot design required 14.0 minutes of optimization, and will require 178.3 minutes for automated delivery. Conclusion: The dual focal spot optimization and delivery framework is a novel option for delivering conformal and heterogeneous dose distributions at the preclinical level and provides a new experimental option for unique radiobiological investigations

  2. Neutron flux characterisation of the Pavia TRIGA Mark II research reactor for radiobiological and microdosimetric applications.

    PubMed

    Alloni, D; Prata, M; Salvini, A; Ottolenghi, A

    2015-09-01

    Nowadays the Pavia TRIGA reactor is available for national and international collaboration in various research fields. The TRIGA Mark II nuclear research reactor of the Pavia University offers different in- and out-core neutron irradiation channels, each characterised by different neutron spectra. In the last two years a campaign of measurements and simulations has been performed in order to guarantee a better characterisation of these different fluxes and to meet the demands of irradiations that require precise information on these spectra in particular for radiobiological and microdosimetric studies. Experimental data on neutron fluxes have been collected analysing and measuring the gamma activity induced in thin target foils of different materials irradiated in different TRIGA experimental channels. The data on the induced gamma activities have been processed with the SAND II deconvolution code and finally compared with the spectra obtained with Monte Carlo simulations. The comparison between simulated and measured spectra showed a good agreement allowing a more precise characterisation of the neutron spectra and a validation of the adopted method. PMID:25958412

  3. Hot particle dosimetry and radiobiology--past and present.

    PubMed

    Charles, M W; Harrison, J D

    2007-09-01

    Small high-activity radioactive particles of nominal diameter ranging from approximately 1 mm down to several microm have been a radiological concern over the last 30 years in and around European and American nuclear reactor facilities. These particles have often been referred to as 'hot particles'. The 'hot particle problem' came into prominent concern in the late 1960s. The potential carcinogenic effects in lungs as the result of irradiation by discrete small particles containing alpha-emitting radionuclides, particularly (239)Pu, were claimed by some to be several orders of magnitude greater than those produced by uniform irradiation to the same mean dose. The phrase 'hot particle problem' was subsequently used to refer to the difficulty of predicting health effects for all microscopic radioactive sources. The difficulty arose because of the paucity of comparative human, animal or cell studies using radioactive particles, and the lack of validated measurement or calculational techniques for dose estimation for non-uniform exposures. Experience was largely restricted to uniform, large-area/volume exposures. The concern regarding cancer induction was extended to deterministic effects when the ICRP in 1977 failed to give adequate dose limits for dealing with 'hot particle' exposures of the skin. Since 1980, considerable efforts have been made to clarify and solve the dosimetric and radiobiological issues related to the health effects of 'hot particle' exposures. The general recommendations of the ICRP in 1991 used the latest radiobiological data to provide skin dose limits which are applicable to 'hot particle' exposures. More recently the NCRP has extended considerations to other organs. This progress is reviewed and applied to the specific case of the recent evaluation of potential health effects of Dounreay fuel fragments commissioned by the Scottish Environment Protection Agency (SEPA). Analyses of possible doses and risks in this case indicate that the

  4. 75 FR 12573 - Advisory Committee on the Electronic Records Archives (ACERA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... From the Federal Register Online via the Government Publishing Office NATIONAL ARCHIVES AND RECORDS ADMINISTRATION Advisory Committee on the Electronic Records Archives (ACERA) AGENCY: National... Advisory Committee Act, as amended (5 U.S.C. Appendix 2), the National Archives and Records...

  5. 36 CFR 1253.7 - Regional Archives.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... at Boston is located in the Frederick C. Murphy Federal Center, 380 Trapelo Rd., Waltham, MA 02452... Saturday hours. The telephone number is 781-663-0130. The National Archives at Boston, Pittsfield Annex...

  6. 36 CFR 1253.7 - Regional Archives.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... National Archives at Boston is located in the Frederick C. Murphy Federal Center, 380 Trapelo Rd., Waltham... Boston, Pittsfield Annex is located at 10 Conte Drive, Pittsfield, MA 01201-8230. The telephone number...

  7. 76 FR 4634 - Proposed Information Collection; Comment Request; Implantation and Recovery of Archival Tags for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ...; Implantation and Recovery of Archival Tags for Highly Migratory Species AGENCY: National Oceanic and... Administration (NOAA) allows scientists to implant archival tags in, or affix archival tags to, selected Atlantic Highly Migratory Species (tunas, sharks, swordfish, and billfish). Archival tags collect...

  8. NOAA Enterprise Archive Access Tool

    NASA Astrophysics Data System (ADS)

    Rank, R. H.; McCormick, S.; Cremidis, C.

    2010-12-01

    A challenge for any consumer of National Oceanic and Atmospheric Administration (NOAA) environmental data archives is that the disparate nature of these archives makes it difficult for consumers to access data in a unified manner. If it were possible for consumers to have seamless access to these archives, they would be able to better utilize the data and thus maximize the return on investment for NOAA’s archival program. When unified data access is coupled with sophisticated data querying and discovery techniques, it will be possible to provide consumers with access to richer data sets and services that extend the use of key NOAA data. Theoretically, there are two ways that unified archive access may be achieved. The first approach is to develop a single archive or archiving standard that would replace the current NOAA archives. However, the development of such an archive would pose significant technical and administrative challenges. The second approach is to develop a middleware application that would provide seamless access to all existing archives, in effect allowing each archive to exist “as is” but providing a translation service for the consumer. This approach is deemed more feasible from an administrative and technical standpoint; however, it still presents unique technical challenges due to the disparate architectures that exist across NOAA archives. NOAA has begun developing the NEAAT. The purpose of NEAAT is to provide a middleware and a simple standardized API between NOAA archives and data consumers. It is important to note that NEAAT serves two main purposes: 1) To provide a single application programming interface (API) that enables designated consumers to write their own custom applications capable of searching and acquiring data seamlessly from multiple NOAA archives. 2) To allow archive managers to expose their data to consumers in conjunction with other NOAA resources without modifying their archiving systems or way of presenting data

  9. Amchitka Radiobiological Program progress report, January 1979-December 1979

    SciTech Connect

    Thornberg, L.D.; Sibley, T.H.; Nakatani, R.E.

    1980-07-01

    The objective of the Amchitka Radiobiological Program for the period 1970-1979 was to determine the extent of radionuclide contamination from world-wide atmospheric fallout and from the detonation of three underground nuclear blasts on Amchitka Island. The objective is achieved, by the collection and radiological analyses of biological and environmental samples and by background radiation measurements. Leakage of radionuclides from the underground sites of the Amchitka nuclear detonations would be suspected if the contamination was significntly greater than would be expected from world fallout. An account of the program from July 1970 to December 1978 has been given in nine previous reports from the Laboratory of Radiation Ecology to the Nevada Operations Office of the US Department of Energy. This report is an account of the program for calendar year 1979. The results of analyses of the samples collected in 1979 lead to the same conclusions as in previous years; i.e., there is no evidence that the radionuclide contamination at Amchitka Island is greater than would be expected from world fallout except for a slight contamination of the Long Shot Mud Pits with tritium.

  10. Amchitka Radiobiological Program. Final report, July 1970-December 1979

    SciTech Connect

    Sibley, T.H.; Tornberg, L.D.

    1982-11-01

    The Amchitka Radiobiological Program, to collect biological and environmental samples for radiological analyses, began in 1970 and continued through 1979. The principal objective was to determine the extent of radionuclide contamination from worldwide atmospheric fallout and from the detonation of three underground nuclear tests on Amchitka. Leakage of radionuclides from the underground test sites would be suspected if the amount of contamination was significantly greater than could be attributed to worldwide fallout or if an unexpected assemblage of radionuclides was detected. No radionuclides from the underground sites were detected, except for tritium from the Long Shot test (1965) which produced increased tritium concentrations in surface water and freshwater plants near the test site. This final report compiles all previous data into one report and considers the temporal trends in these data. Two naturally occurring radionuclides, /sup 40/K and /sup 7/Be, were the most abundantly occurring radionuclides in most samples; in lichen samples either /sup 137/Cs or /sup 144/Ce had the highest activity. All samples were below applicable Radiation Protection Guides and by 1979 most samples were near or below the statistical detection limits. Increased concentrations of short-lived fallout radionuclides following the Chinese atmospheric tests were found in freshwater and seawater samples and in most indicator organisms.

  11. Feasibility of BNCT radiobiological experiments at the HYTHOR facility

    NASA Astrophysics Data System (ADS)

    Esposito, J.; Ceballos, C.; Soncin, M.; Fabris, C.; Friso, E.; Moro, D.; Colautti, P.; Jori, G.; Rosi, G.; Nava, E.

    2008-06-01

    HYTHOR (HYbrid Thermal spectrum sHifter tapirO Reactor) is a new thermal-neutron irradiation facility, which was installed and became operative in mid 2005 at the TAPIRO (TAratura PIla Rapida potenza 0) fast reactor, in the Casaccia research centre (near Rome) of ENEA (Ente per le Nuove tecnologie Energia ed Ambiente). The facility has been designed for in vivo radiobiological studies. In HYTHOR irradiation cavity, 1-6 mice can be simultaneously irradiated to study skin melanoma treatments with the BNCT (boron neutron capture therapy). The therapeutic effects of HYTHOR radiation field on mouse melanoma has been studied as a preliminary investigation before studying the tumour local control due to boron neutron capture effect after boronated molecule injection. The method to properly irradiate small animals has been precisely defined. Results show that HYTHOR radiation field is by itself effective in reducing the tumour-growth rate. This finding has to be taken into account in studying the effectiveness of new 10B carriers. A method to properly measure the reduction of the tumour-growth rate is reported and discussed.

  12. Radiobiological study by using laser-driven proton beams

    SciTech Connect

    Yogo, A.; Nishikino, M.; Mori, M.; Ogura, K.; Sagisaka, A.; Orimo, S.; Nishiuchi, M.; Pirozhkov, A. S.; Ikegami, M.; Tampo, M.; Sakaki, H.; Suzuki, M.; Daito, I.; Kiriyama, H.; Okada, H.; Kanazawa, S.; Kondo, S.; Shimomura, T.; Nakai, Y.; Kawachi, T.

    2009-07-25

    Particle acceleration driven by high-intensity laser systems is widely attracting interest as a potential alternative to conventional ion acceleration, including ion accelerator applications to tumor therapy. Recent works have shown that a high intensity laser pulse can produce single proton bunches of a high current and a short pulse duration. This unique feature of laser-ion acceleration can lead to progress in the development of novel ion sources. However, there has been no experimental study of the biological effects of laser-driven ion beams. We describe in this report the first demonstrated irradiation effect of laser-accelerated protons on human lung cancer cells. In-vitro A549 cells are irradiated with a proton dose of 20 Gy, resulting in a distinct formation of gamma-H2AX foci as an indicator of DNA double-strand breaks. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. The laser-driven ion beam is apotential excitation source for time-resolved determination of hydroxyl (OH) radical yield, which will explore relationship between the fundamental chemical reactions of radiation effects and consequent biological processes.

  13. Radiobiological study by using laser-driven proton beams

    NASA Astrophysics Data System (ADS)

    Yogo, A.; Sato, K.; Nishikino, M.; Mori, M.; Teshima, T.; Numasaki, H.; Murakami, M.; Demizu, Y.; Akagi, S.; Nagayama, S.; Ogura, K.; Sagisaka, A.; Orimo, S.; Nishiuchi, M.; Pirozhkov, A. S.; Ikegami, M.; Tampo, M.; Sakaki, H.; Suzuki, M.; Daito, I.; Oishi, Y.; Sugiyama, H.; Kiriyama, H.; Okada, H.; Kanazawa, S.; Kondo, S.; Shimomura, T.; Nakai, Y.; Tanoue, M.; Sugiyama, H.; Sasao, H.; Wakai, D.; Kawachi, T.; Nishimura, H.; Bolton, P. R.; Daido, H.

    2009-07-01

    Particle acceleration driven by high-intensity laser systems is widely attracting interest as a potential alternative to conventional ion acceleration, including ion accelerator applications to tumor therapy. Recent works have shown that a high intensity laser pulse can produce single proton bunches of a high current and a short pulse duration. This unique feature of laser-ion acceleration can lead to progress in the development of novel ion sources. However, there has been no experimental study of the biological effects of laser-driven ion beams. We describe in this report the first demonstrated irradiation effect of laser-accelerated protons on human lung cancer cells. In-vitro A549 cells are irradiated with a proton dose of 20 Gy, resulting in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. The laser-driven ion beam is apotential excitation source for time-resolved determination of hydroxyl (OH) radical yield, which will explore relationship between the fundamental chemical reactions of radiation effects and consequent biological processes.

  14. [Radiobiological analysis of cancerogenic risk values in radioepidemiological investigations].

    PubMed

    Rozhdestvenskiĭ, L M

    2008-01-01

    The aim of the present article consisted in critical analysis of the epidemiological approach to radiocancerogenic risk estimation in region of low level radiation (LLR). The estimation is making by means of mathematician models that ignore a principal difference in biological action of LLR and high level radiation (HLR). The main formal characteristic of LLR action is the presence of a plateau in beginning of a dose-effect curve of radiogenic risk. It may be argued by the following positions: repeating the plateau-phenomenon on various radiobiological effects, in different tests and bioobjects, first; a paradoxical trend of reciprocal ERR/Sv increasing regarding dose decreasing in region of plateau, second, and third, the increasing of the curvature in dose-effect curve beginning. The presence of a plateau is associated with the presence of a real radiogenic risk threshold. Besides, the analysis of processes influencing significantly the dynamics of initial radiation injury of biologically important macromolecules showed the preference in region of LLR those, decreasing/eliminating genome damages. There is follows from mentioned above a necessity to evaluate radiogenic risks in LLR region separately from HLR region. PMID:18825986

  15. Three-Dimensional Radiobiologic Dosimetry: Application of Radiobiologic Modeling to Patient-Specific 3-Dimensional Imaging–Based Internal Dosimetry

    PubMed Central

    Prideaux, Andrew R.; Song, Hong; Hobbs, Robert F.; He, Bin; Frey, Eric C.; Ladenson, Paul W.; Wahl, Richard L.; Sgouros, George

    2010-01-01

    Phantom-based and patient-specific imaging-based dosimetry methodologies have traditionally yielded mean organ-absorbed doses or spatial dose distributions over tumors and normal organs. In this work, radiobiologic modeling is introduced to convert the spatial distribution of absorbed dose into biologically effective dose and equivalent uniform dose parameters. The methodology is illustrated using data from a thyroid cancer patient treated with radioiodine. Methods Three registered SPECT/CT scans were used to generate 3-dimensional images of radionuclide kinetics (clearance rate) and cumulated activity. The cumulated activity image and corresponding CT scan were provided as input into an EGSnrc-based Monte Carlo calculation: The cumulated activity image was used to define the distribution of decays, and an attenuation image derived from CT was used to define the corresponding spatial tissue density and composition distribution. The rate images were used to convert the spatial absorbed dose distribution to a biologically effective dose distribution, which was then used to estimate a single equivalent uniform dose for segmented volumes of interest. Equivalent uniform dose was also calculated from the absorbed dose distribution directly. Results We validate the method using simple models; compare the dose-volume histogram with a previously analyzed clinical case; and give the mean absorbed dose, mean biologically effective dose, and equivalent uniform dose for an illustrative case of a pediatric thyroid cancer patient with diffuse lung metastases. The mean absorbed dose, mean biologically effective dose, and equivalent uniform dose for the tumor were 57.7, 58.5, and 25.0 Gy, respectively. Corresponding values for normal lung tissue were 9.5, 9.8, and 8.3 Gy, respectively. Conclusion The analysis demonstrates the impact of radiobiologic modeling on response prediction. The 57% reduction in the equivalent dose value for the tumor reflects a high level of dose

  16. Novel Radiobiological Gamma Index for Evaluation of 3-Dimensional Predicted Dose Distribution

    SciTech Connect

    Sumida, Iori; Yamaguchi, Hajime; Kizaki, Hisao; Aboshi, Keiko; Tsujii, Mari; Yoshikawa, Nobuhiko; Yamada, Yuji; Suzuki, Osamu; Seo, Yuji; Isohashi, Fumiaki; Yoshioka, Yasuo; Ogawa, Kazuhiko

    2015-07-15

    Purpose: To propose a gamma index-based dose evaluation index that integrates the radiobiological parameters of tumor control (TCP) and normal tissue complication probabilities (NTCP). Methods and Materials: Fifteen prostate and head and neck (H&N) cancer patients received intensity modulated radiation therapy. Before treatment, patient-specific quality assurance was conducted via beam-by-beam analysis, and beam-specific dose error distributions were generated. The predicted 3-dimensional (3D) dose distribution was calculated by back-projection of relative dose error distribution per beam. A 3D gamma analysis of different organs (prostate: clinical [CTV] and planned target volumes [PTV], rectum, bladder, femoral heads; H&N: gross tumor volume [GTV], CTV, spinal cord, brain stem, both parotids) was performed using predicted and planned dose distributions under 2%/2 mm tolerance and physical gamma passing rate was calculated. TCP and NTCP values were calculated for voxels with physical gamma indices (PGI) >1. We propose a new radiobiological gamma index (RGI) to quantify the radiobiological effects of TCP and NTCP and calculate radiobiological gamma passing rates. Results: The mean RGI gamma passing rates for prostate cases were significantly different compared with those of PGI (P<.03–.001). The mean RGI gamma passing rates for H&N cases (except for GTV) were significantly different compared with those of PGI (P<.001). Differences in gamma passing rates between PGI and RGI were due to dose differences between the planned and predicted dose distributions. Radiobiological gamma distribution was visualized to identify areas where the dose was radiobiologically important. Conclusions: RGI was proposed to integrate radiobiological effects into PGI. This index would assist physicians and medical physicists not only in physical evaluations of treatment delivery accuracy, but also in clinical evaluations of predicted dose distribution.

  17. Reference Services in Archives.

    ERIC Educational Resources Information Center

    Whalen, Lucille; And Others

    1986-01-01

    This 16-article issue focuses on history, policy, services, users, organization, evaluation, and automation of the archival reference process. Collections at academic research libraries, a technical university, Board of Education, business archives, a bank, labor and urban archives, a manuscript repository, religious archives, and regional history…

  18. Physical Review Online Archives (PROLA)

    SciTech Connect

    Thomas, T.; Davies, J.; Kilman, D.; Laroche, F.

    1997-05-01

    In cooperation with the American Physical Society, the Computer Research and Applications Group (CIC-3 -- see Section 13 for an acronym glossary) at Los Alamos National Laboratory has developed and deployed a journal archive system called, The Physical Review OnLine Archive (PROLA). It is intended to be a complete, full service on-line archive of the existing issues of the journal Physical Review from its inception to the advent of a full-service electronic version. The fundamental goals of PROLA are to provide screen-viewable and printable images of every article, full-text and fielded search capability, good browsing features, direct article retrieval tools, and hyperlinking to all references, errata, and comments. The research focus is on transitioning large volumes of paper journals to a modern electronic environment.

  19. Sensitivity Analysis of Parameters in Linear-Quadratic Radiobiologic Modeling

    SciTech Connect

    Fowler, Jack F.

    2009-04-01

    Purpose: Radiobiologic modeling is increasingly used to estimate the effects of altered treatment plans, especially for dose escalation. The present article shows how much the linear-quadratic (LQ) (calculated biologically equivalent dose [BED] varies when individual parameters of the LQ formula are varied by {+-}20% and by 1%. Methods: Equivalent total doses (EQD2 = normalized total doses (NTD) in 2-Gy fractions for tumor control, acute mucosal reactions, and late complications were calculated using the linear- quadratic formula with overall time: BED = nd (1 + d/ [{alpha}/{beta}]) - log{sub e}2 (T - Tk) / {alpha}Tp, where BED is BED = total dose x relative effectiveness (RE = nd (1 + d/ [{alpha}/{beta}]). Each of the five biologic parameters in turn was altered by {+-}10%, and the altered EQD2s tabulated; the difference was finally divided by 20. EQD2 or NTD is obtained by dividing BED by the RE for 2-Gy fractions, using the appropriate {alpha}/{beta} ratio. Results: Variations in tumor and acute mucosal EQD ranged from 0.1% to 0.45% per 1% change in each parameter for conventional schedules, the largest variation being caused by overall time. Variations in 'late' EQD were 0.4% to 0.6% per 1% change in the only biologic parameter, the {alpha}/{beta} ratio. For stereotactic body radiotherapy schedules, variations were larger, up to 0.6 to 0.9 for tumor and 1.6% to 1.9% for late, per 1% change in parameter. Conclusions: Robustness occurs similar to that of equivalent uniform dose (EUD), for the same reasons. Total dose, dose per fraction, and dose-rate cause their major effects, as well known.

  20. SU-E-T-385: 4D Radiobiology

    SciTech Connect

    Fourkal, E; Hossain, M; Veltchev, I; Ma, C; Meyer, J; Horwitz, E; Nahum, A

    2014-06-01

    Purpose: The linear-quadratic model is the most prevalent model for planning dose fractionation in radiation therapy in the low dose per fraction regimens. However for high-dose fractions, used in SRS/SBRT/HDR treatments the LQ model does not yield accurate predictions, due to neglecting the reduction in the number of sublethal lesions as a result of their conversion to lethal lesions with subsequent irradiation. Proper accounting for this reduction in the number of sublethally damaged lesions leads to the dependence of the survival fraction on the temporal structure of the dose. The main objective of this work is to show that the functional dependence of the dose rate on time in each voxel is an important additional factor that can significantly influence the TCP. Methods: Two SBRT lung plans have been used to calculate the TCPs for the same patient. One plan is a 3D conformal plan and the other is an IMRT plan. Both plans are normalized so that 99.5% of PTV volume receives the same prescription dose of 50 Gy in 5 fractions. The dose rate in each individual voxel is calculated as a function of treatment time and subsequently used in the calculation of TCP. Results: The calculated TCPs show that shorter delivery times lead to greater TCP, despite all delivery times being short compared to the repair half-time for sublethal lesions. Furthermore, calculated TCP(IMRT) =0.308 for the IMRT plan is smaller than TCP(3D) =0.425 for 3D conformal, even though it shows greater tumor hot spots and equal PTV coverage. The calculated TCPs are considerably lower compared to those based on the LQ model for which TCP=1 for both plans. Conclusion: The functional dependence of the voxel-by-voxel dose rate on time may be an important factor in predicting the treatment outcome and cannot be neglected in radiobiological modeling.

  1. Heavy-ion tumor therapy: Physical and radiobiological benefits

    NASA Astrophysics Data System (ADS)

    Schardt, Dieter; Elsässer, Thilo; Schulz-Ertner, Daniela

    2010-01-01

    High-energy beams of charged nuclear particles (protons and heavier ions) offer significant advantages for the treatment of deep-seated local tumors in comparison to conventional megavolt photon therapy. Their physical depth-dose distribution in tissue is characterized by a small entrance dose and a distinct maximum (Bragg peak) near the end of range with a sharp fall-off at the distal edge. Taking full advantage of the well-defined range and the small lateral beam spread, modern scanning beam systems allow delivery of the dose with millimeter precision. In addition, projectiles heavier than protons such as carbon ions exhibit an enhanced biological effectiveness in the Bragg peak region caused by the dense ionization of individual particle tracks resulting in reduced cellular repair. This makes them particularly attractive for the treatment of radio-resistant tumors localized near organs at risk. While tumor therapy with protons is a well-established treatment modality with more than 60 000 patients treated worldwide, the application of heavy ions is so far restricted to a few facilities only. Nevertheless, results of clinical phase I-II trials provide evidence that carbon-ion radiotherapy might be beneficial in several tumor entities. This article reviews the progress in heavy-ion therapy, including physical and technical developments, radiobiological studies and models, as well as radiooncological studies. As a result of the promising clinical results obtained with carbon-ion beams in the past ten years at the Heavy Ion Medical Accelerator facility (Japan) and in a pilot project at GSI Darmstadt (Germany), the plans for new clinical centers for heavy-ion or combined proton and heavy-ion therapy have recently received a substantial boost.

  2. Heavy-ion tumor therapy: Physical and radiobiological benefits

    SciTech Connect

    Schardt, Dieter; Elsaesser, Thilo; Schulz-Ertner, Daniela

    2010-01-15

    High-energy beams of charged nuclear particles (protons and heavier ions) offer significant advantages for the treatment of deep-seated local tumors in comparison to conventional megavolt photon therapy. Their physical depth-dose distribution in tissue is characterized by a small entrance dose and a distinct maximum (Bragg peak) near the end of range with a sharp fall-off at the distal edge. Taking full advantage of the well-defined range and the small lateral beam spread, modern scanning beam systems allow delivery of the dose with millimeter precision. In addition, projectiles heavier than protons such as carbon ions exhibit an enhanced biological effectiveness in the Bragg peak region caused by the dense ionization of individual particle tracks resulting in reduced cellular repair. This makes them particularly attractive for the treatment of radio-resistant tumors localized near organs at risk. While tumor therapy with protons is a well-established treatment modality with more than 60 000 patients treated worldwide, the application of heavy ions is so far restricted to a few facilities only. Nevertheless, results of clinical phase I-II trials provide evidence that carbon-ion radiotherapy might be beneficial in several tumor entities. This article reviews the progress in heavy-ion therapy, including physical and technical developments, radiobiological studies and models, as well as radiooncological studies. As a result of the promising clinical results obtained with carbon-ion beams in the past ten years at the Heavy Ion Medical Accelerator facility (Japan) and in a pilot project at GSI Darmstadt (Germany), the plans for new clinical centers for heavy-ion or combined proton and heavy-ion therapy have recently received a substantial boost.

  3. The Midwest State Archives Guide Project: An Evaluation. [Final Report.

    ERIC Educational Resources Information Center

    Evans, Max J.; And Others

    This document serves as the final report to the National Historical Publications and Records Commission (NHPRC) of the work of the Midwest State Archives Guide Project. The project involved the state archives in Minnesota, Illinois, Indiana, and Wisconsin, and was expected to contribute to a projected national guide project database, though when…

  4. Radiobiological compensation: A case study of uterine cervix cancer with concurrent chemotherapy

    SciTech Connect

    Herrera, Higmar; Yanez, Elvia; Lopez, Jesus

    2012-10-23

    The case of a patient diagnosed with uterine cervix cancer is presented as an example of the clinical application of the radiobiological compensation method implemented at Centro Estatal de Cancerologia de Durango. Radiotherapy treatment was initially modified to compensate for the chemotherapy component and, as medical complications arose during treatment delivery resulting in an 18 days gap, new compensation followed. All physical and radiobiological assumptions to calculate the Biologically Effective Dose in the external beam and brachytherapy parts of the treatment are presented. Good local control of the tumor was achieved, the theoretical tolerance limits for the organs at risk were not surpassed and the patient manifested no extensive morbidity.

  5. Radiobiological compensation: A case study of uterine cervix cancer with concurrent chemotherapy

    NASA Astrophysics Data System (ADS)

    Herrera, Higmar; Yañez, Elvia; López, Jesús

    2012-10-01

    The case of a patient diagnosed with uterine cervix cancer is presented as an example of the clinical application of the radiobiological compensation method implemented at Centro Estatal de Cancerología de Durango. Radiotherapy treatment was initially modified to compensate for the chemotherapy component and, as medical complications arose during treatment delivery resulting in an 18 days gap, new compensation followed. All physical and radiobiological assumptions to calculate the Biologically Effective Dose in the external beam and brachytherapy parts of the treatment are presented. Good local control of the tumor was achieved, the theoretical tolerance limits for the organs at risk were not surpassed and the patient manifested no extensive morbidity.

  6. DoD's Medical Radiobiology Advisory Team: experts on the ground.

    PubMed

    VanHorne-Sealy, Jama; Livingston, Brian; Alleman, Lee

    2012-05-01

    The Medical Radiobiology Advisory Team (MRAT) is the operations arm of the Armed Forces Radiobiology Research Institute (AFRRI), located at Naval Support Activity in Bethesda, MD. AFRRI is internationally recognized as expert in the biological effects of ionizing radiation research, training, and mitigation. During the U.S. Department of Defense's (DoD) response to the Fukushima Daiichi reactor incident, Operation Tomodachi, the MRAT provided guidance and advice to the U.S. Military leaders in Japan. This support helped ensure the safety of U.S. service members, family members, and civilians and supported the humanitarian relief in a coordinated effort with the Government of Japan (GOJ). PMID:22469928

  7. A system approach to archival storage

    NASA Technical Reports Server (NTRS)

    Corcoran, John W.

    1991-01-01

    The introduction and viewgraphs of a discussion on a system approach to archival storage presented at the National Space Science Data Center (NSSDC) Mass Storage Workshop is included. The use of D-2 iron particles for archival storage is discussed along with how acceleration factors relating short-term tests to archival life times can be justified. Ampex Recording Systems is transferring D-2 video technology to data storage applications, and encountering concerns about corrosion. To protect the D-2 standard, Battelle tests were done on all four tapes in the Class 2 environment. Error rates were measured before and after the test on both exposed and control groups.

  8. Mapping the Socio-Technical Complexity of Australian Science: From Archival Authorities to Networks of Contextual Information

    ERIC Educational Resources Information Center

    McCarthy, Gavan; Evans, Joanne

    2007-01-01

    This article examines the evolution of a national register of the archives of science and technology in Australia and the related development of an archival informatics focused initially on people and their relationships to archival materials. The register was created in 1985 as an in-house tool for the Australian Science Archives Project of the…

  9. Radiobiological effects of heavy ions and protons. [on cells of mammals, bacteria and viruses

    NASA Technical Reports Server (NTRS)

    Ryzhov, N. I.; Vorozhtsova, S. V.; Krasavin, Y. A.; Mashinskaya, T. Y.; Savchenko, N. Y.; Fedorov, B. S.; Khlaponina, V. F.; Shelegedin, V. N.; Gut, L.; Sabo, L.

    1974-01-01

    Radiobiological effects of heavy ions and protons are studied on cells of mammals, bacteria, viruses and DNA of bacteria. Results show that the dose effect dependence bears an exponential character; the reduction of RBE as LET of particle increases reflects the different character of microdistribution of absorbed energy in biological objects with different levels of biological organization.

  10. Fluctuations in energy loss and their implications for dosimetry and radiobiology

    NASA Technical Reports Server (NTRS)

    Baily, N. A.; Steigerwalt, J. E.

    1972-01-01

    Serious consideration of the physics of energy deposition indicates that a fundamental change in the interpretation of absorbed dose is required at least for considerations of effects in biological systems. In addition, theoretical approaches to radiobiology and microdosimetry seem to require statistical considerations incorporating frequency distributions of the magnitude of the event sizes within the volume of interest.

  11. Researching Television News Archives.

    ERIC Educational Resources Information Center

    Wilhoit, Frances Goins

    To demonstrate the uses and efficiency of major television news archives, a study was conducted to describe major archival programs and to compare the Vanderbilt University Television News Archives and the CBS News Index. Network coverage of an annual news event, the 1983 State of the Union address, is traced through entries in both. The findings…

  12. My Dream Archive

    ERIC Educational Resources Information Center

    Phelps, Christopher

    2007-01-01

    In this article, the author shares his experience as he traveled from island to island with a single objective--to reach the archives. He found out that not all archives are the same. In recent months, his daydreaming in various facilities has yielded a recurrent question on what would constitute the Ideal Archive. What follows, in no particular…

  13. Assessing the shift of radiobiological metrics in lung radiotherapy plans using 2D gamma index

    PubMed Central

    Balosso, Jacques

    2016-01-01

    Background The purpose of this work is to investigate the 2D gamma (γ) maps to illustrate the change of radiobiological outcomes for lung radiotherapy plans and evaluate the correlation between tumor control probability (TCP), normal tissue complication probability (NTCP) with γ passing rates (γ-rates). Methods Nine patients with lung cancer were used. The doses were calculated using Modified Batho method integrated with pencil beam convolution (MB-PBC) and anisotropic analytical algorithm (AAA) using the same beam arrangements and prescription dose. The TCP and NTCP were estimated, respectively, using equivalent uniform dose (EUD) model and Lyman-Kutcher-Burman (LKB) model. The correlation between ΔTCP or ΔNTCP with γ-rates, from 2%/2 and 3%/3 mm, were tested to explore the best correlation predicting the relevant γ criteria using Spearman’s rank test (ρ). Wilcoxon paired test was used to calculate P value. Results TCP value was significantly lower in the recalculated AAA plans as compared to MB plans. However, AAA predicted more NTCP on lung pneumonitis according to the LKB model and using relevant radiobiological parameters (n, m and TD50) for MB-PBC and AAA, with P=0.03. The data showed a weak correlation between radiobiological metrics with γ-rates or γ-mean, ρ<0.3. Conclusions AAA and MB yield different TCP values as well as NTCP for lung pneumonitis based on the LKB model parameters. Therefore, 2D γ-maps, generated with 2%/2 or 3%/3 mm, could illustrate visual information about the radiobiological changes. The information is useful to evaluate the clinical outcome of a radiotherapy treatment and to approve the treatment plan of the patient if the dose constraints are respected. On the other hand, the γ-maps tool can be used as quality assurance (QA) process to check the predicted TCP and NTCP from radiobiological models. PMID:27413708

  14. Life Sciences Data Archive (LSDA)

    NASA Technical Reports Server (NTRS)

    Fitts, M.; Johnson-Throop, Kathy; Thomas, D.; Shackelford, K.

    2008-01-01

    In the early days of spaceflight, space life sciences data were been collected and stored in numerous databases, formats, media-types and geographical locations. While serving the needs of individual research teams, these data were largely unknown/unavailable to the scientific community at large. As a result, the Space Act of 1958 and the Science Data Management Policy mandated that research data collected by the National Aeronautics and Space Administration be made available to the science community at large. The Biomedical Informatics and Health Care Systems Branch of the Space Life Sciences Directorate at JSC and the Data Archive Project at ARC, with funding from the Human Research Program through the Exploration Medical Capability Element, are fulfilling these requirements through the systematic population of the Life Sciences Data Archive. This program constitutes a formal system for the acquisition, archival and distribution of data for Life Sciences-sponsored experiments and investigations. The general goal of the archive is to acquire, preserve, and distribute these data using a variety of media which are accessible and responsive to inquiries from the science communities.

  15. Introduction: Consider the Archive.

    PubMed

    Yale, Elizabeth

    2016-03-01

    In recent years, historians of archives have paid increasingly careful attention to the development of state, colonial, religious, and corporate archives in the early modern period, arguing that power (of various kinds) was mediated and extended through material writing practices in and around archives. The history of early modern science, likewise, has tracked the production of scientific knowledge through the inscription and circulation of written records within and between laboratories, libraries, homes, and public spaces, such as coffeehouses and bookshops. This Focus section interrogates these two bodies of scholarship against each other. The contributors ask how archival digitization is transforming historical practice; how awareness of archival histories can help us to reconceptualize our work as historians of science; how an archive's layered purposes, built up over centuries of record keeping, can shape the historical narratives we write; and how scientific knowledge emerging from archives gained authority and authenticity. PMID:27197412

  16. Archive of side scan sonar and swath bathymetry data collected during USGS cruise 10CCT03 offshore of the Gulf Islands National Seashore, Mississippi, from East Ship Island, Mississippi, to Dauphin Island, Alabama, April 2010

    USGS Publications Warehouse

    DeWitt, Nancy T.; Flocks, James G.; Pfeiffer, William R.; Gibson, James N.; Wiese, Dana S.

    2012-01-01

    Data were collected aboard the U.S. Army Corps of Engineers (USACE) SV Irvington, a 56-foot (ft) Kvichak Marine Industries, Inc., catamaran (fig. 2). Side scan sonar and multibeam bathymetry data were collected simultaneously along the tracklines. The side scan sonar towfish was towed off the starboard side just slightly behind the vessel, close to the seafloor. The multibeam transducer was attached to a retractable strut-arm lowered between the catamaran hulls. Navigation was acquired with an Applanix POS MV and differentially corrected using the broadcast signal from a local National Geodetic Survey (NGS) Continuously Operating Reference Station (CORS) beacon. See the digital FACS equipment log for details about the acquisition equipment used. Raw datasets were stored digitally and processed using HYPACK Inc., HYSWEEP software at the USACE Mobile, Ala., District office. For more information on processing refer to the Equipment and Processing page. Chirp seismic data were also collected during this survey and are archived separately.

  17. Metrically preserving the USGS aerial film archive

    USGS Publications Warehouse

    Moe, Donald; Longhenry, Ryan

    2013-01-01

    Since 1972, the U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center in Sioux Falls, South Dakota, has provided fi lm-based products to the public. EROS is home to an archive of 12 million frames of analog photography ranging from 1937 to the present. The archive contains collections from both aerial and satellite platforms including programs such as the National High Altitude Program (NHAP), National Aerial Photography Program (NAPP), U.S. Antarctic Resource Center (USARC), Declass 1(CORONA, ARGON, and LANYARD), Declass 2 (KH-7 and KH-9), and Landsat (1972 – 1992, Landsat 1–5).

  18. AstroCloud, a Cyber-Infrastructure for Astronomy Research: Data Archiving and Quality Control

    NASA Astrophysics Data System (ADS)

    He, B.; Cui, C.; Fan, D.; Li, C.; Xiao, J.; Yu, C.; Wang, C.; Cao, Z.; Chen, J.; Yi, W.; Li, S.; Mi, L.; Yang, S.

    2015-09-01

    AstroCloud is a cyber-Infrastructure for Astronomy Research initiated by Chinese Virtual Observatory (China-VO) under funding support from NDRC (National Development and Reform commission) and CAS (Chinese Academy of Sciences)1(Cui et al. 2014). To archive the astronomical data in China, we present the implementation of the astronomical data archiving system (ADAS). Data archiving and quality control are the infrastructure for the AstroCloud. Throughout the data of the entire life cycle, data archiving system standardized data, transferring data, logging observational data, archiving ambient data, And storing these data and metadata in database. Quality control covers the whole process and all aspects of data archiving.

  19. 12. HISTORIC PHOTOGRAPH OF CONSTRUCTION OF FIRST NATIONAL BANK BUILDING. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. HISTORIC PHOTOGRAPH OF CONSTRUCTION OF FIRST NATIONAL BANK BUILDING. PHOTOGRAPHER AND DATE UNKNOWN. (First National Bank Archives) - First National Bank, 1206 Eleventh Avenue, Altoona, Blair County, PA

  20. 76 FR 65218 - Advisory Committee on the Electronic Records Archives (ACERA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... RECORDS ADMINISTRATION Advisory Committee on the Electronic Records Archives (ACERA) AGENCY: National... (NARA) announces a meeting of the Advisory Committee on the Electronic Records Archives (ACERA). The..., and service issues related to the Electronic Records Archives (ERA). This includes, but is not...

  1. 75 FR 63208 - Advisory Committee on the Electronic Records Archives (ACERA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... RECORDS ADMINISTRATION Advisory Committee on the Electronic Records Archives (ACERA) AGENCY: National... (NARA) announces a meeting of the Advisory Committee on the Electronic Records Archives (ACERA). The..., and service issues related to the Electronic Records Archives (ERA). This includes, but is not...

  2. 76 FR 19147 - Advisory Committee on the Electronic Records Archives (ACERA)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... RECORDS ADMINISTRATION Advisory Committee on the Electronic Records Archives (ACERA) AGENCY: National... Administration (NARA) announces an agenda change for the Advisory Committee on the Electronic Records Archives... to attend must be submitted to the Electronic Records Archives Program at era.program@nara.gov ....

  3. 77 FR 21812 - Advisory Committee on the Electronic Records Archives (ACERA).

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... RECORDS ADMINISTRATION Advisory Committee on the Electronic Records Archives (ACERA). AGENCY: National... (NARA) announces a meeting of the Advisory Committee on the Electronic Records Archives (ACERA). The..., and service issues related to the Electronic Records Archives (ERA). This includes, but is not...

  4. Writings on Archives Published by and with the Assistance of UNESCO: A RAMP Study.

    ERIC Educational Resources Information Center

    Evans, Frank B.

    Compiled as part of the United Nations Educational, Scientific and Cultural Organization (UNESCO) Records and Archives Management Programme (RAMP), this document lists 282 writings published by or with the assistance of UNESCO on the subject of archives administration and archival materials (interpreted broadly to include current and semi-current…

  5. 36 CFR 1254.62 - Does NARA have archival materials protected by copyright?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Does NARA have archival materials protected by copyright? 1254.62 Section 1254.62 Parks, Forests, and Public Property NATIONAL... MATERIALS Copying Archival Materials General Information § 1254.62 Does NARA have archival...

  6. 36 CFR 1254.62 - Does NARA have archival materials protected by copyright?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 3 2011-07-01 2011-07-01 false Does NARA have archival materials protected by copyright? 1254.62 Section 1254.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Copying Archival Materials...

  7. 36 CFR 1254.62 - Does NARA have archival materials protected by copyright?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Does NARA have archival materials protected by copyright? 1254.62 Section 1254.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Copying Archival Materials...

  8. 36 CFR 1254.62 - Does NARA have archival materials protected by copyright?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Does NARA have archival materials protected by copyright? 1254.62 Section 1254.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Copying Archival Materials...

  9. 36 CFR 1254.62 - Does NARA have archival materials protected by copyright?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Does NARA have archival materials protected by copyright? 1254.62 Section 1254.62 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION PUBLIC AVAILABILITY AND USE USING RECORDS AND DONATED HISTORICAL MATERIALS Copying Archival Materials...

  10. Standards and Methodologies for Characterizing Radiobiological Impact of High-Z Nanoparticles

    PubMed Central

    Subiel, Anna; Ashmore, Reece; Schettino, Giuseppe

    2016-01-01

    Research on the application of high-Z nanoparticles (NPs) in cancer treatment and diagnosis has recently been the subject of growing interest, with much promise being shown with regards to a potential transition into clinical practice. In spite of numerous publications related to the development and application of nanoparticles for use with ionizing radiation, the literature is lacking coherent and systematic experimental approaches to fully evaluate the radiobiological effectiveness of NPs, validate mechanistic models and allow direct comparison of the studies undertaken by various research groups. The lack of standards and established methodology is commonly recognised as a major obstacle for the transition of innovative research ideas into clinical practice. This review provides a comprehensive overview of radiobiological techniques and quantification methods used in in vitro studies on high-Z nanoparticles and aims to provide recommendations for future standardization for NP-mediated radiation research. PMID:27446499

  11. Effects of radiobiological uncertainty on shield design for a 60-day lunar mission

    NASA Technical Reports Server (NTRS)

    Wilson, John W.; Nealy, John E.; Schimmerling, Walter

    1993-01-01

    Some consequences of uncertainties in radiobiological risk due to galactic cosmic ray exposure are analyzed to determine their effect on engineering designs for a first lunar outpost - a 60-day mission. Quantitative estimates of shield mass requirements as a function of a radiobiological uncertainty factor are given for a simplified vehicle structure. The additional shield mass required for compensation is calculated as a function of the uncertainty in galactic cosmic ray exposure, and this mass is found to be as large as a factor of 3 for a lunar transfer vehicle. The additional cost resulting from this mass is also calculated. These cost estimates are then used to exemplify the cost-effectiveness of research.

  12. [From microdosimetry to nanodosimetry--the link between radiobiology and radiation physics].

    PubMed

    Fu, Yuchuan; Li, Ping

    2014-06-01

    The link between micro- and macro-parameters for radiation interactions that take place in living biological systems is described in this paper. Meanwhile recent progress and development in microdosimetry and nanodosimetry are introduced, including the methods to measure and calculate these micro- or nano-parameters. The relationship between radiobiology and physical quantities in microdosimetry and nanodosimetry was presented. Both the current problems on their applications in radiation protection and radiotherapy and the future development direction are proposed. PMID:25219261

  13. Physical conditions for conducting radiobiological experiments in beams of accelerated particles with high linear energy transfer

    NASA Technical Reports Server (NTRS)

    Kudryashov, Y. I.; Marennyy, A. M.; Popov, V. I.; Aykhorn, K.; Ertsgreber, G.

    1974-01-01

    The design and construction of an accelerator to conduct radiobiological experiments is reported that uses aluminum filters to control the accelerated ion beam while preserving its stability, and a vacuum chamber to conduct the ion beam with the help of a collector through a lavsan exit port to the target. Depth distribution of the absorbed dose from a monodirectional ion beam is practically completely represented by the change in the energy spectrum of the biological object.

  14. Ill-posed problem and regularization in reconstruction of radiobiological parameters from serial tumor imaging data

    NASA Astrophysics Data System (ADS)

    Chvetsov, Alevei V.; Sandison, George A.; Schwartz, Jeffrey L.; Rengan, Ramesh

    2015-11-01

    The main objective of this article is to improve the stability of reconstruction algorithms for estimation of radiobiological parameters using serial tumor imaging data acquired during radiation therapy. Serial images of tumor response to radiation therapy represent a complex summation of several exponential processes as treatment induced cell inactivation, tumor growth rates, and the rate of cell loss. Accurate assessment of treatment response would require separation of these processes because they define radiobiological determinants of treatment response and, correspondingly, tumor control probability. However, the estimation of radiobiological parameters using imaging data can be considered an inverse ill-posed problem because a sum of several exponentials would produce the Fredholm integral equation of the first kind which is ill posed. Therefore, the stability of reconstruction of radiobiological parameters presents a problem even for the simplest models of tumor response. To study stability of the parameter reconstruction problem, we used a set of serial CT imaging data for head and neck cancer and a simplest case of a two-level cell population model of tumor response. Inverse reconstruction was performed using a simulated annealing algorithm to minimize a least squared objective function. Results show that the reconstructed values of cell surviving fractions and cell doubling time exhibit significant nonphysical fluctuations if no stabilization algorithms are applied. However, after applying a stabilization algorithm based on variational regularization, the reconstruction produces statistical distributions for survival fractions and doubling time that are comparable to published in vitro data. This algorithm is an advance over our previous work where only cell surviving fractions were reconstructed. We conclude that variational regularization allows for an increase in the number of free parameters in our model which enables development of more

  15. [Radiobiological characteristics of chilled seedlings as an object for inflight experiments].

    PubMed

    Shaĭdorov, Iu I; Miller, A T; Fischere, G A

    1975-01-01

    It is recommended to use for experimentation cooled plant seedlings in the stage of delayed growth. Cooled seedlings have a high sensitivity to the environmental effects and can be used in long-term (up to 1-2 months) experiments. The influence of suboptimal temperatures on the radiosensitivity of seedlings, the development of radiation injury and maintenance of the radiobiological effect is described. PMID:1214486

  16. The GTC Public Archive

    NASA Astrophysics Data System (ADS)

    Alacid, J. Manuel; Solano, Enrique

    2015-12-01

    The Gran Telescopio Canarias (GTC) archive is operational since November 2011. The archive, maintained by the Data Archive Unit at CAB in the framework of the Spanish Virtual Observatory project, provides access to both raw and science ready data and has been designed in compliance with the standards defined by the International Virtual Observatory Alliance (IVOA) to guarantee a high level of data accessibility and handling. In this presentation I will describe the main capabilities the GTC archive offers to the community, in terms of functionalities and data collections, to carry out an efficient scientific exploitation of GTC data.

  17. The NEON Soil Archive - A community resource

    NASA Astrophysics Data System (ADS)

    Ayres, E.

    2013-12-01

    The National Ecological Observatory Network (NEON) is a 30-year National Science Foundation-funded facility for understanding and forecasting the impacts of climate change, land use change, and invasive species on aspects of continental-scale ecology such as biodiversity, biogeochemistry, infectious diseases, and ecohydrology. NEON will measure a wide range of properties at 60 terrestrial and 36 aquatic sites throughout the US using in situ sensors, sample collection/lab analysis, and remote sensing, and all data will be made freely available. The Observatory is currently under construction and will be fully operational by 2017, however, limited data collection and release will begin in 2013. In addition, NEON is archiving large numbers of samples, including surface soils (top ~30 cm) collected from locations across each site, and soils collected by horizon to 2 m deep from a single soil pit at each site. Here I present information about the latter, focusing on sampling and processing, metadata, and currently available samples. At each terrestrial site the soil pit is dug in the locally dominant soil type and soil is collected by horizon, mixed, and ~4-8 liters soil is sent for processing. Soil samples are air-dried and sieved (mineral soil) or air-dried (organic soil) and 1.2 kg is split between 4 glass jars for archiving (protocol available upon request). To date 15 soil pits have been sampled, representing 7 soil orders, and soils from 110 horizons have been archived or are being processed. Metadata associated with each archive sample include a soil profile description, photos, and soil properties (total C, N, S, Al, Ca, Fe, K, Mg, Mn, Na, P, Si, Sr, Ti, Zr, bulk density, pH, and texture). The procedure for requesting samples from the archive is under development and I encourage scientists to use the archive in their future research. Collecting and processing samples for the NEON Soil Archive

  18. 50 CFR 635.33 - Archival tags.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Archival tags. 635.33 Section 635.33 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION.... (d) Quota monitoring. If an Atlantic HMS landed under the authority of paragraph (b) of this...

  19. Web Archiving at the Library of Congress

    ERIC Educational Resources Information Center

    Grotke, Abbie

    2011-01-01

    Recent years have seen an explosion of the number of institutions involved in or beginning to think about web archiving. Many National Digital Stewardship Alliance (NDSA) members, as well as other universities, historical societies, and state and local governments, have recognized the need for and importance of preserving a variety of web content…

  20. Network accessible multi-terabyte archive

    NASA Technical Reports Server (NTRS)

    Rybczynski, Fred

    1991-01-01

    The viewgraphs of a discussion on Network Accessible Multi-terabyte Archive presented at the National Space Science Data Center (NSSDC) Mass Storage Workshop is included. Topics covered in the presentation include the rotary storage system (RSS) including RSS data access, data management, administration, and hardware and software architecture.

  1. Archive of side scan sonar and swath bathymetry data collected during USGS cruise 10CCT01 offshore of Cat Island, Gulf Islands National Seashore, Mississippi, March 2010

    USGS Publications Warehouse

    DeWitt, Nancy T.; Flocks, James G.; Pfeiffer, William R.; Wiese, Dana S.

    2010-01-01

    In March of 2010, the U.S. Geological Survey (USGS) conducted geophysical surveys east of Cat Island, Mississippi (fig. 1). The efforts were part of the USGS Gulf of Mexico Science Coordination partnership with the U.S. Army Corps of Engineers (USACE) to assist the Mississippi Coastal Improvements Program (MsCIP) and the Northern Gulf of Mexico (NGOM) Ecosystem Change and Hazards Susceptibility Project by mapping the shallow geological stratigraphic framework of the Mississippi Barrier Island Complex. These geophysical surveys will provide the data necessary for scientists to define, interpret, and provide baseline bathymetry and seafloor habitat for this area and to aid scientists in predicting future geomorpholocial changes of the islands with respect to climate change, storm impact, and sea-level rise. Furthermore, these data will provide information for barrier island restoration, particularly in Camille Cut, and provide protection for the historical Fort Massachusetts. For more information refer to http://ngom.usgs.gov/gomsc/mscip/index.html. This report serves as an archive of the processed swath bathymetry and side scan sonar data (SSS). Data products herein include gridded and interpolated surfaces, surface images, and x,y,z data products for both swath bathymetry and side scan sonar imagery. Additional files include trackline maps, navigation files, GIS files, Field Activity Collection System (FACS) logs, and formal FGDC metadata. Scanned images of the handwritten FACS logs and digital FACS logs are also provided as PDF files. Refer to the Acronyms page for expansion of acronyms and abbreviations used in this report or hold the cursor over an acronym for a pop-up explanation. The USGS St. Petersburg Coastal and Marine Science Center assigns a unique identifier to each cruise or field activity. For example, 10CCT01 tells us the data were collected in 2010 for the Coastal Change and Transport (CCT) study and the data were collected during the first field

  2. Cancer imaging archive available

    Cancer.gov

    NCI’s Cancer Imaging Program has inaugurated The Cancer Imaging Archive (TCIA), a web-accessible and unique clinical imaging archive linked to The Cancer Genome Atlas (TCGA) tissue repository. It contains a large proportion of original, pre-surgical MRIs from cases that have been genomically characterized in TCGA.

  3. [Church Archives; Selected Papers.

    ERIC Educational Resources Information Center

    Abraham, Terry; And Others

    Papers presented at the Institute which were concerned with keeping of church archives are entitled: "St. Mary's Episcopal Church, Eugene, Oregon;""Central Lutheran Church, Eugene, Oregon: A History;""Mormon Church Archives: An Overview;""Sacramental Records of St. Mary's Catholic Church, Eugene, Oregon;""Chronology of St. Mary's Catholic Church,…

  4. The NASA Exoplanet Archive

    NASA Astrophysics Data System (ADS)

    Ramirez, Solange; Akeson, R. L.; Ciardi, D.; Kane, S. R.; Plavchan, P.; von Braun, K.; NASA Exoplanet Archive Team

    2013-01-01

    The NASA Exoplanet Archive is an online service that compiles and correlates astronomical information on extra solar planets and their host stars. The data in the archive include exoplanet parameters (such as orbits, masses, and radii), associated data (such as published radial velocity curves, photometric light curves, images, and spectra), and stellar parameters (such as magnitudes, positions, and temperatures). All the archived data are linked to the original literature reference.The archive provides tools to work with these data, including interactive tables (with plotting capabilities), interactive light curve viewer, periodogram service, transit and ephemeris calculator, and application program interface.The NASA Exoplanet Archive is the U.S. portal to the public CoRoT mission data for both the Exoplanet and Asteroseismology data sets. The NASA Exoplanet Archive also serves data related to Kepler Objects of Interest (Planet Candidates and the Kepler False Positives, KOI) in an integrated and interactive table containing stellar and transit parameters. In support of the Kepler Extended Mission, the NASA Exoplanet Archive will host transit modeling parameters, centroid results, several statistical values, and summary and detailed reports for all transit-like events identified by the Kepler Pipeline. To access this information visit us at: http://exoplanetarchive.ipac.caltech.edu

  5. The Golosyiv plate archive digitisation

    NASA Astrophysics Data System (ADS)

    Sergeeva, T. P.; Sergeev, A. V.; Pakuliak, L. K.; Yatsenko, A. I.

    2007-08-01

    The plate archive of the Main Astronomical Observatory of the National Academy of Sciences of Ukraine (Golosyiv, Kyiv) includes about 85 000 plates which have been taken in various observational projects during 1950-2005. Among them are about 25 000 of direct northern sky area plates and more than 600 000 plates containing stellar, planetary and active solar formations spectra. Direct plates have a limiting magnitude of 14.0-16.0 mag. Since 2002 we have been organising the storage, safeguarding, cataloguing and digitization of the plate archive. The very initial task was to create the automated system for detection of astronomical objects and phenomena, search of optical counterparts in the directions of gamma-ray bursts, research of long period, flare and other variable stars, search and rediscovery of asteroids, comets and other Solar System bodies to improve the elements of their orbits, informational support of CCD observations and space projects, etc. To provide higher efficiency of this work we have prepared computer readable catalogues and database for 250 000 direct wide field plates. Now the catalogues have been adapted to Wide Field Plate Database (WFPDB) format and integrated into this world database. The next step will be adaptation of our catalogues, database and images to standards of the IVOA. Some magnitude and positional accuracy estimations for Golosyiv archive plates have been done. The photometric characteristics of the images of NGC 6913 cluster stars on two plates of the Golosyiv's double wide angle astrograph have been determined. Very good conformity of the photometric characteristics obtained with external accuracies of 0.13 and 0.15 mag. has been found. The investigation of positional accuracy have been made with A3± format fixed bed scanner (Microtek ScanMaker 9800XL TMA). It shows that the scanner has non-detectable systematic errors on the X-axis, and errors of ± 15 μm on the Y-axis. The final positional errors are about ± 2 μm (

  6. The Planetary Archive

    NASA Astrophysics Data System (ADS)

    Penteado, Paulo F.; Trilling, David; Szalay, Alexander; Budavári, Tamás; Fuentes, César

    2014-11-01

    We are building the first system that will allow efficient data mining in the astronomical archives for observations of Solar System Bodies. While the Virtual Observatory has enabled data-intensive research making use of large collections of observations across multiple archives, Planetary Science has largely been denied this opportunity: most astronomical data services are built based on sky positions, and moving objects are often filtered out.To identify serendipitous observations of Solar System objects, we ingest the archive metadata. The coverage of each image in an archive is a volume in a 3D space (RA,Dec,time), which we can represent efficiently through a hierarchical triangular mesh (HTM) for the spatial dimensions, plus a contiguous time interval. In this space, an asteroid occupies a curve, which we determine integrating its orbit into the past. Thus when an asteroid trajectory intercepts the volume of an archived image, we have a possible observation of that body. Our pipeline then looks in the archive's catalog for a source with the corresponding coordinates, to retrieve its photometry. All these matches are stored into a database, which can be queried by object identifier.This database consists of archived observations of known Solar System objects. This means that it grows not only from the ingestion of new images, but also from the growth in the number of known objects. As new bodies are discovered, our pipeline can find archived observations where they could have been recorded, providing colors for these newly-found objects. This growth becomes more relevant with the new generation of wide-field surveys, particularly LSST.We also present one use case of our prototype archive: after ingesting the metadata for SDSS, 2MASS and GALEX, we were able to identify serendipitous observations of Solar System bodies in these 3 archives. Cross-matching these occurrences provided us with colors from the UV to the IR, a much wider spectral range than that

  7. The Herschel Science Archive

    NASA Astrophysics Data System (ADS)

    Verdugo, Eva

    2015-12-01

    The Herschel mission required a Science Archive able to serve data to very different users: The own Data Analysis Software (both Pipeline and Interactive Analysis), the consortia of the different instruments and the scientific community. At the same time, the KP consortia were committed to deliver to the Herschel Science Centre, the processed products corresponding to the data obtained as part of their Science Demonstration Phase and the Herschel Archive should include the capability to store and deliver them. I will explain how the current Herschel Science Archive is designed to cover all these requirements.

  8. The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?

    PubMed

    Brown, J Martin; Carlson, David J; Brenner, David J

    2014-02-01

    Stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiation therapy (SABR), are rapidly becoming accepted practice for the radiation therapy of certain tumors. Typically, SRS and SBRT involve the delivery of 1 or a few large-dose fractions of 8 to 30 Gy per fraction: a major paradigm shift from radiation therapy practice over the past 90 years, when, with relatively large amounts of normal tissues receiving high doses, the goal was to maximize tumor response for an acceptable level of normal tissue injury. The development of SRS and SBRT have come about because of technologic advances in image guidance and treatment delivery techniques that enable the delivery of large doses to tumors with reduced margins and high gradients outside the target, thereby minimizing doses to surrounding normal tissues. Because the results obtained with SRS and SBRT have been impressive, they have raised the question whether classic radiobiological modeling, and the linear-quadratic (LQ) model, are appropriate for large doses per fraction. In addition to objections to the LQ model, the possibility of additional biological effects resulting from endothelial cell damage, enhanced tumor immunity, or both have been raised to account for the success of SRS and SBRT. In this review, we conclude that the available preclinical and clinical data do not support a need to change the LQ model or to invoke phenomena over and above the classic 5 Rs of radiobiology and radiation therapy, with the likely exception that for some tumors high doses of irradiation may produce enhanced antitumor immunity. Thus, we suggest that for most tumors, the standard radiobiology concepts of the 5 Rs are sufficient to explain the clinical data, and the excellent results obtained from clinical studies are the result of the much larger biologically effective doses that are delivered with SRS and SBRT. PMID:24411596

  9. Issues for Simulation of Galactic Cosmic Ray Exposures for Radiobiological Research at Ground-Based Accelerators.

    PubMed

    Kim, Myung-Hee Y; Rusek, Adam; Cucinotta, Francis A

    2015-01-01

    For radiobiology research on the health risks of galactic cosmic rays (GCR) ground-based accelerators have been used with mono-energetic beams of single high charge, Z and energy, E (HZE) particles. In this paper, we consider the pros and cons of a GCR reference field at a particle accelerator. At the NASA Space Radiation Laboratory (NSRL), we have proposed a GCR simulator, which implements a new rapid switching mode and higher energy beam extraction to 1.5 GeV/u, in order to integrate multiple ions into a single simulation within hours or longer for chronic exposures. After considering the GCR environment and energy limitations of NSRL, we performed extensive simulation studies using the stochastic transport code, GERMcode (GCR Event Risk Model) to define a GCR reference field using 9 HZE particle beam-energy combinations each with a unique absorber thickness to provide fragmentation and 10 or more energies of proton and (4)He beams. The reference field is shown to well represent the charge dependence of GCR dose in several energy bins behind shielding compared to a simulated GCR environment. However, a more significant challenge for space radiobiology research is to consider chronic GCR exposure of up to 3 years in relation to simulations with animal models of human risks. We discuss issues in approaches to map important biological time scales in experimental models using ground-based simulation, with extended exposure of up to a few weeks using chronic or fractionation exposures. A kinetics model of HZE particle hit probabilities suggests that experimental simulations of several weeks will be needed to avoid high fluence rate artifacts, which places limitations on the experiments to be performed. Ultimately risk estimates are limited by theoretical understanding, and focus on improving knowledge of mechanisms and development of experimental models to improve this understanding should remain the highest priority for space radiobiology research. PMID:26090339

  10. Radiobiological Determination of Dose Escalation and Normal Tissue Toxicity in Definitive Chemoradiation Therapy for Esophageal Cancer

    SciTech Connect

    Warren, Samantha; Partridge, Mike; Carrington, Rhys; Hurt, Chris; Crosby, Thomas; Hawkins, Maria A.

    2014-10-01

    Purpose: This study investigated the trade-off in tumor coverage and organ-at-risk sparing when applying dose escalation for concurrent chemoradiation therapy (CRT) of mid-esophageal cancer, using radiobiological modeling to estimate local control and normal tissue toxicity. Methods and Materials: Twenty-one patients with mid-esophageal cancer were selected from the SCOPE1 database (International Standard Randomised Controlled Trials number 47718479), with a mean planning target volume (PTV) of 327 cm{sup 3}. A boost volume, PTV2 (GTV + 0.5 cm margin), was created. Radiobiological modeling of tumor control probability (TCP) estimated the dose required for a clinically significant (+20%) increase in local control as 62.5 Gy/25 fractions. A RapidArc (RA) plan with a simultaneously integrated boost (SIB) to PTV2 (RA{sub 62.5}) was compared to a standard dose plan of 50 Gy/25 fractions (RA{sub 50}). Dose-volume metrics and estimates of normal tissue complication probability (NTCP) for heart and lungs were compared. Results: Clinically acceptable dose escalation was feasible for 16 of 21 patients, with significant gains (>18%) in tumor control from 38.2% (RA{sub 50}) to 56.3% (RA{sub 62.5}), and only a small increase in predicted toxicity: median heart NTCP 4.4% (RA{sub 50}) versus 5.6% (RA{sub 62.5}) P<.001 and median lung NTCP 6.5% (RA{sub 50}) versus 7.5% (RA{sub 62.5}) P<.001. Conclusions: Dose escalation to the GTV to improve local control is possible when overlap between PTV and organ-at-risk (<8% heart volume and <2.5% lung volume overlap for this study) generates only negligible increase in lung or heart toxicity. These predictions from radiobiological modeling should be tested in future clinical trials.

  11. The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?

    SciTech Connect

    Brown, J. Martin; Carlson, David J.; Brenner, David J.

    2014-02-01

    Stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiation therapy (SABR), are rapidly becoming accepted practice for the radiation therapy of certain tumors. Typically, SRS and SBRT involve the delivery of 1 or a few large-dose fractions of 8 to 30 Gy per fraction: a major paradigm shift from radiation therapy practice over the past 90 years, when, with relatively large amounts of normal tissues receiving high doses, the goal was to maximize tumor response for an acceptable level of normal tissue injury. The development of SRS and SBRT have come about because of technologic advances in image guidance and treatment delivery techniques that enable the delivery of large doses to tumors with reduced margins and high gradients outside the target, thereby minimizing doses to surrounding normal tissues. Because the results obtained with SRS and SBRT have been impressive, they have raised the question whether classic radiobiological modeling, and the linear-quadratic (LQ) model, are appropriate for large doses per fraction. In addition to objections to the LQ model, the possibility of additional biological effects resulting from endothelial cell damage, enhanced tumor immunity, or both have been raised to account for the success of SRS and SBRT. In this review, we conclude that the available preclinical and clinical data do not support a need to change the LQ model or to invoke phenomena over and above the classic 5 Rs of radiobiology and radiation therapy, with the likely exception that for some tumors high doses of irradiation may produce enhanced antitumor immunity. Thus, we suggest that for most tumors, the standard radiobiology concepts of the 5 Rs are sufficient to explain the clinical data, and the excellent results obtained from clinical studies are the result of the much larger biologically effective doses that are delivered with SRS and SBRT.

  12. Estimation of Radiobiologic Parameters and Equivalent Radiation Dose of Cytotoxic Chemotherapy in Malignant Glioma

    SciTech Connect

    Jones, Bleddyn . E-mail: b.jones.1@bham.ac.uk; Sanghera, Paul

    2007-06-01

    Purpose: To determine the radiobiologic parameters for high-grade gliomas. Methods and Materials: The biologic effective dose concept is used to estimate the {alpha}/{beta} ratio and K (dose equivalent for tumor repopulation/d) for high-grade glioma patients treated in a randomized fractionation trial. The equivalent radiation dose of temozolomide (Temodar) chemotherapy was estimated from another randomized study. The method assumes that the radiotherapy biologic effective dose is proportional to the adjusted radiotherapy survival duration of high-grade glioma patients. Results: The median tumor {alpha}/{beta} and K estimate is 9.32 Gy and 0.23 Gy/d, respectively. Using the published surviving fraction after 2-Gy exposure (SF{sub 2}) data, and the above {alpha}/{beta} ratio, the estimated median {alpha} value was 0.077 Gy{sup -1}, {beta} was 0.009 Gy{sup -2}, and the cellular doubling time was 39.5 days. The median equivalent biologic effective dose of temozolomide was 11.03 Gy{sub 9.3} (equivalent to a radiation dose of 9.1 Gy given in 2-Gy fractions). Random sampling trial simulations based on a cure threshold of 70 Gy in high-grade gliomas have shown the potential increase in tumor cure with dose escalation. Partial elimination of hypoxic cells (by chemical hypoxic cell sensitizers or carbon ion therapy) has suggested that considerable gains in tumor control, which are further supplemented by temozolomide, are achievable. Conclusion: The radiobiologic parameters for human high-grade gliomas can be estimated from clinical trials and could be used to inform future clinical trials, particularly combined modality treatments with newer forms of radiotherapy. Other incurable cancers should be studied using similar radiobiologic analysis.

  13. Development of a compact laser-produced plasma soft X-ray source for radiobiology experiments

    NASA Astrophysics Data System (ADS)

    Adjei, Daniel; Ayele, Mesfin Getachew; Wachulak, Przemyslaw; Bartnik, Andrzej; Wegrzynski, Łukasz; Fiedorowicz, Henryk; Vyšín, Luděk; Wiechec, Anna; Lekki, Janusz; Kwiatek, Wojciech M.; Pina, Ladislav; Davídková, Marie; Juha, Libor

    2015-12-01

    A desk-top laser-produced plasma (LPP) source of soft X-rays (SXR) has been developed for radiobiology research. The source is based on a double-stream gas puff target, irradiated with the focused beam of a commercial Nd:YAG laser. The source has been optimized to get a maximum photon emission from LPP in the X-ray "water window" spectral wavelength range from 2.3 nm (i.e., an absorption edge of oxygen) to 4.4 nm (i.e., an absorption edge of carbon) (280-540 eV in photon energy units) by using argon gas-puff target and spectral filtering by free-standing thin foils. The present source delivers nanosecond pulses of soft X-rays at a fluence of about 4.2 × 103 photons/μm2/pulse on a sample placed inside the vacuum chamber. In this paper, the source design, radiation output characterization measurements and initial irradiation experiments are described. The source can be useful in addressing observations related to biomolecular, cellular and organisms' sensitivity to pulsed radiation in the "water window", where carbon atoms absorb X-rays more strongly than the oxygen, mostly present in water. The combination of the SXR source and the radiobiology irradiation layout, reported in this article, make possible a systematic investigation of relationships between direct and indirect action of ionizing radiation, an increase of a local dose in carbon-rich compartments of the cell (e.g., lipid membranes), an experimental estimation of a particular role of the Auger effect (in particular in carbon atoms) in the damage to biological systems, and the study of ionization/excitation-density (LET - Linear Energy Transfer) and dose-rate effects in radiobiology.

  14. Issues for Simulation of Galactic Cosmic Ray Exposures for Radiobiological Research at Ground-Based Accelerators

    PubMed Central

    Kim, Myung-Hee Y.; Rusek, Adam; Cucinotta, Francis A.

    2015-01-01

    For radiobiology research on the health risks of galactic cosmic rays (GCR) ground-based accelerators have been used with mono-energetic beams of single high charge, Z and energy, E (HZE) particles. In this paper, we consider the pros and cons of a GCR reference field at a particle accelerator. At the NASA Space Radiation Laboratory (NSRL), we have proposed a GCR simulator, which implements a new rapid switching mode and higher energy beam extraction to 1.5 GeV/u, in order to integrate multiple ions into a single simulation within hours or longer for chronic exposures. After considering the GCR environment and energy limitations of NSRL, we performed extensive simulation studies using the stochastic transport code, GERMcode (GCR Event Risk Model) to define a GCR reference field using 9 HZE particle beam–energy combinations each with a unique absorber thickness to provide fragmentation and 10 or more energies of proton and 4He beams. The reference field is shown to well represent the charge dependence of GCR dose in several energy bins behind shielding compared to a simulated GCR environment. However, a more significant challenge for space radiobiology research is to consider chronic GCR exposure of up to 3 years in relation to simulations with animal models of human risks. We discuss issues in approaches to map important biological time scales in experimental models using ground-based simulation, with extended exposure of up to a few weeks using chronic or fractionation exposures. A kinetics model of HZE particle hit probabilities suggests that experimental simulations of several weeks will be needed to avoid high fluence rate artifacts, which places limitations on the experiments to be performed. Ultimately risk estimates are limited by theoretical understanding, and focus on improving knowledge of mechanisms and development of experimental models to improve this understanding should remain the highest priority for space radiobiology research. PMID:26090339

  15. SU-E-T-194: From Dicom-RT to Radiobiological Dose Metrics in 5 Minutes

    SciTech Connect

    Whelan, B; Holloway, L

    2014-06-01

    Purpose: To develop a flexible and standalone framework for batch calculation of radiobiological dose metrics from Dicom-RT. Methods: Software has been developed which allows (1) The calculation of DVH data from DICOM dose and structure files (DVHgenerator), (2) Calculation of a wide range of radiobiological metrics from this data (CompPlanGui). Both these tools are run via graphical user interface (GUI), making them fast and simple. Part 1 is a new tool which has not previously been published, whilst part 2 is a GUI overlay for the previously published software ‘Comp-Plan’ (Holloway et. al., Medical Dosimetry, 2012), previously reliant on command line interface. The time taken for an experienced user to evaluate a test case of 6 plans with and without CompPlanGUI was quantified. Results: The DVH-generator has been found to be faster, more robust and require far less physical memory then using alternative software solutions for the same purpose. The Comp Plan GUI significantly reduces the amount of time required to set up a base directory, eliminates code crashes arising from typographical errors, and renders the code far more accessible to non-expert users. It took an experienced user of the code around 3 minutes to set up a base directory of 6 plans compared around 8 minutes without, indicating that using CompPlanGUI reduced setup time by over 50%. Conclusion: A standalone GUI based framework has developed which allows for the batch calculation of radiobiological dose metrics directly from Dicom-RT files. As with the original code, this work will be made freely available on request, as well as via matlab file exchange.

  16. User interface development and metadata considerations for the Atmospheric Radiation Measurement (ARM) archive

    NASA Technical Reports Server (NTRS)

    Singley, P. T.; Bell, J. D.; Daugherty, P. F.; Hubbs, C. A.; Tuggle, J. G.

    1993-01-01

    This paper will discuss user interface development and the structure and use of metadata for the Atmospheric Radiation Measurement (ARM) Archive. The ARM Archive, located at Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee, is the data repository for the U.S. Department of Energy's (DOE's) ARM Project. After a short description of the ARM Project and the ARM Archive's role, we will consider the philosophy and goals, constraints, and prototype implementation of the user interface for the archive. We will also describe the metadata that are stored at the archive and support the user interface.

  17. The new hybrid thermal neutron facility at TAPIRO reactor for BNCT radiobiological experiments.

    PubMed

    Esposito, J; Rosi, G; Agosteo, S

    2007-01-01

    A new thermal neutron irradiation facility, devoted to carry out both dosimetric and radiobiological studies on boron carriers, which are being developed in the framework of INFN BNCT project, has been installed at the ENEA Casaccia TAPIRO research fast reactor. The thermal column, based on an original, hybrid, neutron spectrum shifter configuration, has been recently become operative. In spite of its low power (5 kW), the new facility is able to provide a high thermal neutron flux level, uniformly distributed inside the irradiation cavity, with a quite low gamma background. The main features and preliminary benchmark measurements of the Beam-shaping assembly are here presented and discussed. PMID:17504745

  18. Nuclear Physics and Radiobiology - Issues for Humans in Space and on Earth

    NASA Astrophysics Data System (ADS)

    Tripathi, Ram

    2008-10-01

    Nuclear physics is playing a vital role in human biological applications, specifically in planned space missions, in hadron radiotherapy, and in low dose radiobiology. While seemingly disparate, these and other areas share a common need for the understanding of nuclear interactions in biological systems. Radiobiology continues to provide valuable information that will help develop better methods for using radiation in the treatment of disease as well as provide a scientific basis for radiation protection standards. NASA is now focused on the agency's vision for space exploration encompassing a broad range of human and robotic missions including missions to the Moon, Mars and beyond. As a result, there is a focus on long duration space missions. Protection from hazards of space radiation has been identified as one of the five NASA critical areas for human space flight. The cost effective design of spacecraft demands a very stringent requirement on the optimization process. Exposures from the hazards of severe space radiation in deep space and/or long duration missions are very different from that of low earth orbit, and much needs to be done about their effects. However, it is clear that revolutionary technologies will need to be developed. Here on earth, particulate radiation treatment for cancer, such as proton radiotherapy, is playing an increasing important role, while the biological effectiveness remains less well understood than for x-rays and other forms of medical radiation treatments. Advanced imaging, dosimetric, Monte Carlo, and other techniques from nuclear physics are utilized to study the molecular basis of fractionation dependency and other tumor and normal tissue radiation responses, such as radiosensitivity. Moreover, advances developed by biological research efforts, such as the sequencing of the human genome, have opened new horizons for radiobiology. New techniques have made it possible to determine at the cellular / molecular level how living

  19. Non-targeted radiation effects in vivo: a critical glance of the future in radiobiology.

    PubMed

    Hatzi, Vasiliki I; Laskaratou, Danae A; Mavragani, Ifigeneia V; Nikitaki, Zacharenia; Mangelis, Anastasios; Panayiotidis, Mihalis I; Pantelias, Gabriel E; Terzoudi, Georgia I; Georgakilas, Alexandros G

    2015-01-01

    Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology. PMID:24333869

  20. Research in radiobiology. Annual report of work in progress in the Internal Irradiation Program

    SciTech Connect

    Miller, S.C.

    1980-03-31

    Survival data on 160 nonirradiated control beagles of the University of Utah's Radiobiology Laboratory were analyzed. The animals died during a period from 1958 into 1979. The average age at death of animals which died during the 1958 to 1965 interval was significantly less than that of those whose deaths occurred in the 1965 to 1979 interval. The best estimate for average age at death for Super-Selected nonirradiated control beagles of the colony is 4864 +- 901 days. The Super-Selected dogs excluded those dying because of epilepsy, lymphosarcoma, lymphoma or accidents, and also excluded all dogs dying before 1966.

  1. Dosimetry and radiobiology at the new RA-3 reactor boron neutron capture therapy (BNCT) facility: application to the treatment of experimental oral cancer.

    PubMed

    Pozzi, E; Nigg, D W; Miller, M; Thorp, S I; Heber, E M; Zarza, L; Estryk, G; Monti Hughes, A; Molinari, A J; Garabalino, M; Itoiz, M E; Aromando, R F; Quintana, J; Trivillin, V A; Schwint, A E

    2009-07-01

    The National Atomic Energy Commission of Argentina (CNEA) constructed a novel thermal neutron source for use in boron neutron capture therapy (BNCT) applications at the RA-3 research reactor facility located in Buenos Aires. The aim of the present study was to perform a dosimetric characterization of the facility and undertake radiobiological studies of BNCT in an experimental model of oral cancer in the hamster cheek pouch. The free-field thermal flux was 7.1 x 10(9) n cm(-2)s(-1) and the fast neutron flux was 2.5 x 10(6) n cm(-2)s(-1), indicating a very well-thermalized neutron field with negligible fast neutron dose. For radiobiological studies it was necessary to shield the body of the hamster from the neutron flux while exposing the everted cheek pouch bearing the tumors. To that end we developed a lithium (enriched to 95% in (6)Li) carbonate enclosure. Groups of tumor-bearing hamsters were submitted to BPA-BNCT, GB-10-BNCT, (GB-10+BPA)-BNCT or beam only treatments. Normal (non-cancerized) hamsters were treated similarly to evaluate normal tissue radiotoxicity. The total physical dose delivered to tumor with the BNCT treatments ranged from 6 to 8.5 Gy. Tumor control at 30 days ranged from 73% to 85%, with no normal tissue radiotoxicity. Significant but reversible mucositis in precancerous tissue surrounding tumors was associated to BPA-BNCT. The therapeutic success of different BNCT protocols in treating experimental oral cancer at this novel facility was unequivocally demonstrated. PMID:19380233

  2. OPALES: An Environment for Sharing Knowledge Among Experts Working on Multimedia Archives.

    ERIC Educational Resources Information Center

    Betaille, Henri; Nanard, Marc; Nanard, Jocelyne

    INA, the 'Institut National de l'Audiovisuel' keeps records of national TV and radio production as French patrimonial archives. They are mainly accessed by specialists for research purposes, and by TV producers for inserting archive segments within new productions. INA and several other partners have initiated an R&D project, OPALES, to develop a…

  3. Archives and Manuscripts on Microfilm in the Nettie Lee Benson Latin American Collection. A Checklist.

    ERIC Educational Resources Information Center

    Garner, Jane, Comp.

    This collection includes over 6,300 reels of microfilm of unique manuscript and archival holdings from both national and foreign repositories. Most of the material is historical, largely for Mexico from the colonial period to the early twentieth century. Three repositories account for the major portion of the holdings: the National Archives of the…

  4. The Education of Staff and Users for the Proper Handling and Care of Archival Materials: A RAMP Study with Guidelines.

    ERIC Educational Resources Information Center

    Ford, Helen

    The United Nations Educational, Scientific and Cultural Organization (UNESCO) Records and Archives Management Programme (RAMP) works primarily to help developing countries meet archive and record management needs. This study is intended to inform archivists, curators, and users in the proper handling and care of archival materials. The publication…

  5. Cassini Archive Tracking System

    NASA Technical Reports Server (NTRS)

    Conner, Diane; Sayfi, Elias; Tinio, Adrian

    2006-01-01

    The Cassini Archive Tracking System (CATS) is a computer program that enables tracking of scientific data transfers from originators to the Planetary Data System (PDS) archives. Without CATS, there is no systematic means of locating products in the archive process or ensuring their completeness. By keeping a database of transfer communications and status, CATS enables the Cassini Project and the PDS to efficiently and accurately report on archive status. More importantly, problem areas are easily identified through customized reports that can be generated on the fly from any Web-enabled computer. A Web-browser interface and clearly defined authorization scheme provide safe distributed access to the system, where users can perform functions such as create customized reports, record a transfer, and respond to a transfer. CATS ensures that Cassini provides complete science archives to the PDS on schedule and that those archives are available to the science community by the PDS. The three-tier architecture is loosely coupled and designed for simple adaptation to multimission use. Written in the Java programming language, it is portable and can be run on any Java-enabled Web server.

  6. Finding "Science" in the Archives of the Spanish Monarchy.

    PubMed

    Portuondo, Maria M

    2016-03-01

    This essay explores the history of several archives that house the early modern records of Spanish imperial science. The modern "archival turn" urges us to think critically about archives and to recognize in the history of these collections an embedded, often implicit, history that--unless properly recognized, acknowledged, and understood--can distort the histories we are trying to tell. This essay uses a curious episode in the history of science to illustrate how Spanish archives relate to each other and shape the collections they house. During the late eighteenth century a young navy officer, Martín Fernández de Navarrete, was dispatched to all the principal archives of the Spanish monarchy with a peculiar mission: he was to search for evidence that the Spanish in fact had a scientific tradition. This essay uses his mission to explain how the original purpose of an archive--the archive's telos--may persist as a strong and potentially deterministic force in the work of historians of science. In the case of the archives discussed, this telos was shaped by issues as wide ranging as defending a nation's reputation against claims of colonial neglect and as idiosyncratic as an archivist's selection criteria. PMID:27197415

  7. Dynamic Data Management Based on Archival Process Integration at the Centre for Environmental Data Archival

    NASA Astrophysics Data System (ADS)

    Conway, Esther; Waterfall, Alison; Pepler, Sam; Newey, Charles

    2015-04-01

    In this paper we decribe a business process modelling approach to the integration of exisiting archival activities. We provide a high level overview of existing practice and discuss how procedures can be extended and supported through the description of preservation state. The aim of which is to faciliate the dynamic controlled management of scientific data through its lifecycle. The main types of archival processes considered are: • Management processes that govern the operation of an archive. These management processes include archival governance (preservation state management, selection of archival candidates and strategic management) . • Operational processes that constitute the core activities of the archive which maintain the value of research assets. These operational processes are the acquisition, ingestion, deletion, generation of metadata and preservation actvities, • Supporting processes, which include planning, risk analysis and monitoring of the community/preservation environment. We then proceed by describing the feasability testing of extended risk management and planning procedures which integrate current practices. This was done through the CEDA Archival Format Audit which inspected British Atmospherics Data Centre and National Earth Observation Data Centre Archival holdings. These holdings are extensive, comprising of around 2PB of data and 137 million individual files which were analysed and characterised in terms of format based risk. We are then able to present an overview of the risk burden faced by a large scale archive attempting to maintain the usability of heterogeneous environmental data sets. We conclude by presenting a dynamic data management information model that is capable of describing the preservation state of archival holdings throughout the data lifecycle. We provide discussion of the following core model entities and their relationships: • Aspirational entities, which include Data Entity definitions and their associated

  8. Comparison of radiobiological effective depths in 65-MeV modulated proton beams.

    PubMed Central

    Tang, J. T.; Inoue, T.; Inoue, T.; Yamazaki, H.; Fukushima, S.; Fournier-Bidoz, N.; Koizumi, M.; Ozeki, S.; Hatanaka, K.

    1997-01-01

    To assess the achievement of uniformity of radiobiological effectiveness at different depths in the proton spread-out Bragg peak (SOBP), Chinese hamster ovary (CHO) cells were exposed to 65-MeV modulated proton beams at the Research Center for Nuclear Physics (RCNP) of Osaka University. We selected four different irradiation positions: 2 mm depth, corresponding to the entrance, and 10, 18 and 23 mm depths, corresponding to different positions in the SOBP. Cell survival curves were generated with the in vitro colony formation method and fitted to the linear-quadratic model. With 137Cs gamma-rays as the reference irradiation, the relative biological effectiveness (RBE) values for a surviving fraction (SF) level of 0.1 are 1.05, 1.10, 1.12 and 1.19 for depths of 2, 10, 18 and 23 mm respectively. A significant difference was found between the survival curves at 10 and 23 mm (P < 0.05), but not between 18 and 10 mm or between 18 and 23 mm. There was a significant dependence of RBE on depths in modulated proton beams at the 0.1 surviving fraction level (P < 0.05). Moreover, the rise of RBEs significantly depended on increasing SF level or decreased approximately in correspondence with irradiation dose (P = 0.0001). To maintain uniformity of radiobiological effectiveness for the target volume, careful attention should be paid to the influence of depth of beam and irradiation dose. PMID:9231922

  9. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness.

    PubMed

    Blakely, E A; Kronenberg, A

    1998-11-01

    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue. PMID:9806616

  10. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness

    NASA Technical Reports Server (NTRS)

    Blakely, E. A.; Kronenberg, A.; Chatterjee, A. (Principal Investigator)

    1998-01-01

    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue.

  11. Radiobiological characterization of post-lumpectomy focal brachytherapy with lipid nanoparticle-carried radionuclides

    NASA Astrophysics Data System (ADS)

    Hrycushko, Brian A.; Gutierrez, Alonso N.; Goins, Beth; Yan, Weiqiang; Phillips, William T.; Otto, Pamela M.; Bao, Ande

    2011-02-01

    Post-operative radiotherapy has commonly been used for early stage breast cancer to treat residual disease. The primary objective of this work was to characterize, through dosimetric and radiobiological modeling, a novel focal brachytherapy technique which uses direct intracavitary infusion of β-emitting radionuclides (186Re/188Re) carried by lipid nanoparticles (liposomes). Absorbed dose calculations were performed for a spherical lumpectomy cavity with a uniformly injected activity distribution using a dose point kernel convolution technique. Radiobiological indices were used to relate predicted therapy outcome and normal tissue complication of this technique with equivalent external beam radiotherapy treatment regimens. Modeled stromal damage was used as a measure of the inhibition of the stimulatory effect on tumor growth driven by the wound healing response. A sample treatment plan delivering 50 Gy at a therapeutic range of 2.0 mm for 186Re-liposomes and 5.0 mm for 188Re-liposomes takes advantage of the dose delivery characteristics of the β-emissions, providing significant EUD (58.2 Gy and 72.5 Gy for 186Re and 188Re, respectively) with a minimal NTCP (0.046%) of the healthy ipsilateral breast. Modeling of kidney BED and ipsilateral breast NTCP showed that large injected activity concentrations of both radionuclides could be safely administered without significant complications.

  12. Research in radiobiology: Annual report of work in progress in the internal irradiation program

    SciTech Connect

    Miller, S.C.; Buster, D.S.

    1987-12-31

    In the early 1950's the Atomic Energy Commission established at the University of Utah a large, long-term study designed to investigate the toxicity of internally deposited radionuclides in beagles. The first animals were injected on December 1, 1952 and thus began an odyssey unusual in modern science both for its duration and continued scientific interest and relevance. The original dogs were injected with /sup 239/Pu and /sup 226/Ra. Later, studies were initiated with /sup 241/Am, /sup 249/Cf, /sup 252/Cf, /sup 253/Es, /sup 224/Ra, /sup 228/Ra, /sup 90/Sr, and /sup 228/Th. These studies were unique and have and will continue to contribute valuable scientific information on the behavior and effects of these substances in biological systems. We feel that the data collected from these studies will be useful for many decades to come as we ask more demanding questions relative to radionuclides and environmental, biological and health issues. While this publication will be the last of our series Research in Radiobiology, the lifespan carcinogenesis studies are continuing under a collaborative arrangement with the I.T.R.I. Beginning in 1988, the colony status tables of dogs in the Utah studies and reports of research by the Radiobiology faculty will be included in the annual I.T.R.I. report. Under our new collaborative arrangements with the I.T.R.I. for the conduct of the lifespan carcinogenesis studies, we expect a continued high level of scientific productivity from our faculty.

  13. [MODIFICATION OF THE PROTON BEAM PHYSICAL PARAMETERS AND RADIOBIOLOGICAL CHARACTERISTICS BY ELEMENTS OF SPACECRAFT RADIATION PROTECTION].

    PubMed

    Ivanov, A A; Molokanov, A G; Shurshakov, V A; Bulynina, T M; Liakhova, K N; Severiukhin, Yu S; Abrosimova, A N; Ushakov, I B

    2015-01-01

    The experiment was performed with outbred ICR (CD-1). female mice (SPF). The animals were irradiated by 171 MeV protons at a dose of 20 cGy. The spacecraft radiation protection elements used in the experiment were a construction of wet hygiene wipes called a "protective blind", and a glass plate imitating an ISS window. Physical obstacles on the path of 171 MeV protons increase their linear energy transfer leading to the absorbed dose elevation and strengthening of the radiobiological effect. In the experiment, two types of obstacles together raised the absorbed dose from 20 to 23.2 cGy. Chemically different materials (glass and water in the wipes) were found to exert unequal modifying effects on physical and biological parameters of the proton-irradiated mice. There was a distinct dose-dependent reduction of bone marrow cellularity within the dose range from 20 cGy to 23.2 cGy in 24 hours after exposure. No modifying effect of the radiation protection elements on spontaneous motor activity was discovered when compared with entrance protons. The group of animals protected by the glass plate exhibited normal orientative-trying reactions and weakened grip with the forelimbs. Rationalization of physical methods of spacecrew protection should be based as on knowledge in physical dosimetry (ionizing chambers, thermoluminescent, track detectors etc.), so the radiobiological criteria established in experiments with animals. PMID:26738306

  14. Development of a novel experimental model to investigate radiobiological implications of respiratory motion in advanced radiotherapy

    NASA Astrophysics Data System (ADS)

    Cole, Aidan J.; McGarry, Conor K.; Butterworth, Karl T.; Prise, Kevin M.; O'Sullivan, Joe M.; Hounsell, Alan R.

    2012-11-01

    Respiratory motion introduces complex spatio-temporal variations in the dosimetry of radiotherapy. There is a paucity of literature investigating the radiobiological consequences of intrafraction motion and concerns regarding the impact of movement when applied to cancer cell lines in vitro exist. We have addressed this by developing a novel model which accurately replicates respiratory motion under experimental conditions to allow clinically relevant irradiation of cell lines. A bespoke phantom and motor driven moving platform was adapted to accommodate flasks containing medium and cells in order to replicate respiratory motion using varying frequencies and amplitude settings. To study this effect on cell survival in vitro, dose response curves were determined for human lung cancer cell lines H1299 and H460 exposed to a uniform 6 MV radiation field under moving or stationary conditions. Cell survival curves showed no significant difference between irradiation at different dose points for these cell lines in the presence or absence of motion. These data indicate that motion of unshielded cells in vitro does not affect cell survival in the presence of uniform irradiation. This model provides a novel research platform to investigate the radiobiological consequences of respiratory motion in radiotherapy.

  15. The MAO NASU glass archive database: search and management tools

    NASA Astrophysics Data System (ADS)

    Pakuliak, L.

    2005-06-01

    At the Main Astronomical Observatory of the National Academy of Sciences of Ukraine (MAO NASU) the astronomical glass archive counts more than 50,000 of plates obtained in various observational projects during last 50 years of the past century. The local single-user database of glass archive, created on the basis of observational logs and partly on measurement results, has been transformed into an online multy-user system to provide a remote access to the plate archive. In the paper online tools for data searching and database management are presented.

  16. Radiobiologically optimized couch shift: A new localization paradigm using cone-beam CT for prostate radiotherapy

    SciTech Connect

    Huang, Yimei Gardner, Stephen J.; Wen, Ning; Zhao, Bo; Gordon, James; Brown, Stephen; Chetty, Indrin J.

    2015-10-15

    Purpose: To present a novel positioning strategy which optimizes radiation delivery by utilizing radiobiological response knowledge and evaluate its use during prostate external beam radiotherapy. Methods: Five patients with low or intermediate risk prostate cancer were evaluated retrospectively in this IRB-approved study. For each patient, a VMAT plan with one 358° arc was generated on the planning CT (PCT) to deliver 78 Gy in 39 fractions. Five representative pretreatment cone beam CTs (CBCT) were selected for each patient. The CBCT images were registered to PCT by a human observer, which consisted of an initial automated registration with three degrees-of-freedom, followed by manual adjustment for agreement at the prostate/rectal wall interface. To determine the optimal treatment position for each CBCT, a search was performed centering on the observer-matched position (OM-position) utilizing a score function based on radiobiological and dosimetric indices (EUD{sub prostate}, D99{sub prostate}, NTCP{sub rectum}, and NTCP{sub bladder}) for the prostate, rectum, and bladder. We termed the optimal treatment position the radiobiologically optimized couch shift position (ROCS-position). Results: The dosimetric indices, averaged over the five patients’ treatment plans, were (mean ± SD) 79.5 ± 0.3 Gy (EUD{sub prostate}), 78.2 ± 0.4 Gy (D99{sub prostate}), 11.1% ± 2.7% (NTCP{sub rectum}), and 46.9% ± 7.6% (NTCP{sub bladder}). The corresponding values from CBCT at the OM-positions were 79.5 ± 0.6 Gy (EUD{sub prostate}), 77.8 ± 0.7 Gy (D99{sub prostate}), 12.1% ± 5.6% (NTCP{sub rectum}), and 51.6% ± 15.2% (NTCP{sub bladder}), respectively. In comparison, from CBCT at the ROCS-positions, the dosimetric indices were 79.5 ± 0.6 Gy (EUD{sub prostate}), 77.3 ± 0.6 Gy (D99{sub prostate}), 8.0% ± 3.3% (NTCP{sub rectum}), and 46.9% ± 15.7% (NTCP{sub bladder}). Excessive NTCP{sub rectum} was observed on Patient 5 (19.5% ± 6.6%) corresponding to localization at OM

  17. Detection and Occurrence of N-Nitrosamines in Archived Biosolids from the Targeted National Sewage Sludge Survey of the U.S. Environmental Protection Agency

    PubMed Central

    2015-01-01

    The occurrence of eight carcinogenic N-nitrosamines in biosolids from 74 wastewater treatment plants (WWTPs) in the contiguous United States was investigated. Using liquid chromatography-tandem mass spectrometry, seven nitrosamines [(N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine, N-nitrosodi-n-propylamine (NDPA), N-nitrosodibutylamine, N-nitrosopyrrolidine, N-nitrosopiperidine (NPIP), and N-nitrosodiphenylamine (NDPhA)] were detected with varying detection frequency (DF) in 88% of the biosolids samples (n = 80), with five of the seven being reported here for the first time in biosolids. While rarely detected (DF 3%), NDMA was the most abundant compound at an average concentration of 504 ± 417 ng/g dry weight of biosolids. The most frequently detected nitrosamine was NDPhA (0.7—147 ng/g) with a DF of 79%, followed by NDPA (7–505 ng/g) and NPIP (51–1185 ng/g) at 21% and 11%, respectively. The DF of nitrosamines in biosolids was positively correlated with their respective n-octanol–water partition coefficients (R2 = 0.65). The DF and sum of mean concentrations of nitrosamines in biosolids increased with the treatment capacity of WWTPs. Given their frequent occurrence in nationally representative samples and the amount of U.S. biosolids being applied on land as soil amendment, this study warrants more research into the occurrence and fate of nitrosamines in biosolids-amended soils in the context of crop and drinking water safety. PMID:24697330

  18. Detection and occurrence of N-nitrosamines in archived biosolids from the targeted national sewage sludge survey of the U.S. Environmental Protection Agency.

    PubMed

    Venkatesan, Arjun K; Pycke, Benny F G; Halden, Rolf U

    2014-05-01

    The occurrence of eight carcinogenic N-nitrosamines in biosolids from 74 wastewater treatment plants (WWTPs) in the contiguous United States was investigated. Using liquid chromatography-tandem mass spectrometry, seven nitrosamines [(N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine, N-nitrosodi-n-propylamine (NDPA), N-nitrosodibutylamine, N-nitrosopyrrolidine, N-nitrosopiperidine (NPIP), and N-nitrosodiphenylamine (NDPhA)] were detected with varying detection frequency (DF) in 88% of the biosolids samples (n = 80), with five of the seven being reported here for the first time in biosolids. While rarely detected (DF 3%), NDMA was the most abundant compound at an average concentration of 504 ± 417 ng/g dry weight of biosolids. The most frequently detected nitrosamine was NDPhA (0.7-147 ng/g) with a DF of 79%, followed by NDPA (7-505 ng/g) and NPIP (51-1185 ng/g) at 21% and 11%, respectively. The DF of nitrosamines in biosolids was positively correlated with their respective n-octanol-water partition coefficients (R(2) = 0.65). The DF and sum of mean concentrations of nitrosamines in biosolids increased with the treatment capacity of WWTPs. Given their frequent occurrence in nationally representative samples and the amount of U.S. biosolids being applied on land as soil amendment, this study warrants more research into the occurrence and fate of nitrosamines in biosolids-amended soils in the context of crop and drinking water safety. PMID:24697330

  19. Contribution of Polybrominated Dibenzo-p-dioxins and Dibenzofurans (PBDD/Fs) to the Toxic Equivalency of Dioxin-like Compounds in Archived Biosolids from the U.S. EPA’s 2001 National Sewage Sludge Survey

    PubMed Central

    2015-01-01

    The World Health Organization recently proposed the inclusion of brominated congeners in addition to chlorinated congeners when computing the toxic equivalency (TEQ) of dioxin-like compounds (DLCs) in assessments of human health risks. In the present study, 12 polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) were analyzed by gas chromatography/high resolution mass spectrometry in the composited, archived biosolids that were collected in 32 U.S. states and the District of Columbia from 94 wastewater treatment plants by the United States Environmental Protection Agency in its 2001 national sewage sludge survey. Two PBDDs and five PBDFs were detected in the biosolids composites at varying frequencies (40–100%) with a total mean concentration of 10,000 ng/kg dry weight (range: 630–42,800), of which 1,2,3,4,6,7,8-hepta-BDF constituted about 95% by mass. Relative to commercial polybrominated diphenyl ether (PBDE) formulations, the ratio of PBDD/Fs to PBDEs in biosolids was 55-times higher (∼0.002% vs ∼0.11%), which indicates potential PBDE transformation or possibly additional sources of PBDD/Fs in the environment. The TEQ contribution of PBDD/Fs was estimated at 162 ng/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (range: 15–672), which is equivalent to 75% (range: 12–96%) of the total TEQ in biosolids. The TEQ of DLCs released annually to U.S. soils as a result of the land application of biosolids was estimated at 720 g (range: 530–1600 g). Among all known DLCs determined in biosolids, brominated analogs contributed 370% more TEQ than did chlorinated congeners, which indicates the need to include brominated DLCs in the exposure and risk assessment of land-applied biosolids. PMID:25157505

  20. National Archive of Marine Seismic Surveys (NAMSS): A USGS-Boem Partnership to Provide Free and Easy Access to Previously Proprietary Seismic Reflection Data on the U.S. Outer Continental Shelf

    NASA Astrophysics Data System (ADS)

    Triezenberg, P. J.; Hart, P. E.; Childs, J. R.

    2014-12-01

    The National Archive of Marine Seismic Surveys (NAMSS) was established by the USGS in 2004 in an effort to rescue marine seismic reflection profile data acquired largely by the oil exploration industry throughout the US outer continental shelf (OCS). It features a Web interface for easy on-line geographic search and download. The commercial value of these data had decreased significantly because of drilling moratoria and newer acquisition technology, and large quantities were at risk of disposal. But, the data still had tremendous value for scientific research and education purposes, and an effort was undertaken to ensure that the data were preserved and publicly available. More recently, the USGS and Bureau of Ocean Energy Management (BOEM) have developed a partnership to make similarly available a much larger quantity of 2D and 3D seismic data acquired by the U.S. government for assessment of resources in the OCS. Under Federal regulation, BOEM is required to publicly release all processed geophysical data, including seismic profiles, acquired under an exploration permit, purchased and retained by BOEM, no sooner than 25 years after issuance of the permit. Data acquired prior to 1989 are now eligible for release. Currently these data are distributed on CD or DVD, but data discovery can be tedious. Inclusion of these data within NAMSS vastly increases the amount of seismic data available for research purposes. A new NAMSS geographical interface provides easy and intuitive access to the data library. The interface utilizes OpenLayers, Mapnik, and the Django web framework. In addition, metadata capabilities have been greatly increased using a PostgresSQL/PostGIS database incorporating a community-developed ISO-compliant XML template. The NAMSS database currently contains 452 2D seismic surveys comprising 1,645,956 line km and nine 3D seismic surveys covering 9,385 square km. The 2D data holdings consist of stack, migrated and depth sections, most in SEG-Y format.

  1. Radiation transport codes for potential applications related to radiobiology and radiotherapy using protons, neutrons, and negatively charged pions

    NASA Technical Reports Server (NTRS)

    Armstrong, T. W.

    1972-01-01

    Several Monte Carlo radiation transport computer codes are used to predict quantities of interest in the fields of radiotherapy and radiobiology. The calculational methods are described and comparisions of calculated and experimental results are presented for dose distributions produced by protons, neutrons, and negatively charged pions. Comparisons of calculated and experimental cell survival probabilities are also presented.

  2. Radiological and Environmental Research Division, Center for Human Radiobiology. Annual report, July 1980-June 1981. [Lead abstract

    SciTech Connect

    Not Available

    1982-03-01

    Separate abstracts were prepared for the 22 papers of this annual report of the Center for Human Radiobiology. Abstracts were not written for 2 appendices which contain data on the exposure and radium-induced malignancies of 2259 persons whose radium content has been determined at least once. (KRM)

  3. Reading Robin Kelsey's "Archive Style" across the Archival Divide

    ERIC Educational Resources Information Center

    Schwartz, Joan M.

    2008-01-01

    This article presents the author's comments on Robin Kelsey's "Archive Style: Photographs and Illustrations for U.S. Surveys, 1850-1890," a book about government documents that happen to be visual materials. The word "archive" now has intellectual cache in the academic world, but its currency has little to do with the "real world of archives" as…

  4. Training in the Archives: Archival Research as Professional Development

    ERIC Educational Resources Information Center

    Buehl, Jonathan; Chute, Tamar; Fields, Anne

    2012-01-01

    This article describes the rationale and efficacy of a graduate-level teaching module providing loosely structured practice with real archives. Introducing early career scholars to archival methods changed their beliefs about knowledge, research, teaching, and their discipline(s). This case study suggests that archives can be productive training…

  5. The NPARC Alliance Verification and Validation Archive

    NASA Technical Reports Server (NTRS)

    Slater, John W.; Dudek, Julianne C.; Tatum, Kenneth E.

    2000-01-01

    The NPARC Alliance (National Project for Applications oriented Research in CFD) maintains a publicly-available, web-based verification and validation archive as part of the development and support of the WIND CFD code. The verification and validation methods used for the cases attempt to follow the policies and guidelines of the ASME and AIAA. The emphasis is on air-breathing propulsion flow fields with Mach numbers ranging from low-subsonic to hypersonic.

  6. Assessment of radiobiological metrics applied to patient-specific QA process of VMAT prostate treatments.

    PubMed

    Clemente-Gutiérrez, Francisco; Pérez-Vara, Consuelo; Clavo-Herranz, María H; López-Carrizosa, Concepción; Pérez-Regadera, José; Ibáñez-Villoslada, Carmen

    2016-01-01

    VMAT is a powerful technique to deliver hypofractionated prostate treatments. The lack of correlations between usual 2D pretreatment QA results and the clini-cal impact of possible mistakes has allowed the development of 3D verification systems. Dose determination on patient anatomy has provided clinical predictive capability to patient-specific QA process. Dose-volume metrics, as evaluation crite-ria, should be replaced or complemented by radiobiological indices. These metrics can be incorporated into individualized QA extracting the information for response parameters (gEUD, TCP, NTCP) from DVHs. The aim of this study is to assess the role of two 3D verification systems dealing with radiobiological metrics applied to a prostate VMAT QA program. Radiobiological calculations were performed for AAPM TG-166 test cases. Maximum differences were 9.3% for gEUD, -1.3% for TCP, and 5.3% for NTCP calculations. Gamma tests and DVH-based comparisons were carried out for both systems in order to assess their performance in 3D dose determination for prostate treatments (high-, intermediate-, and low-risk, as well as prostate bed patients). Mean gamma passing rates for all structures were bet-ter than 92.0% and 99.1% for both 2%/2 mm and 3%/3 mm criteria. Maximum discrepancies were (2.4% ± 0.8%) and (6.2% ± 1.3%) for targets and normal tis-sues, respectively. Values for gEUD, TCP, and NTCP were extracted from TPS and compared to the results obtained with the two systems. Three models were used for TCP calculations (Poisson, sigmoidal, and Niemierko) and two models for NTCP determinations (LKB and Niemierko). The maximum mean difference for gEUD calculations was (4.7% ± 1.3%); for TCP, the maximum discrepancy was (-2.4% ± 1.1%); and NTCP comparisons led to a maximum deviation of (1.5% ± 0.5%). The potential usefulness of biological metrics in patient-specific QA has been explored. Both systems have been successfully assessed as potential tools for evaluating the clinical

  7. A note on modeling of tumor regression for estimation of radiobiological parameters

    SciTech Connect

    Zhong, Hualiang Chetty, Indrin

    2014-08-15

    Purpose: Accurate calculation of radiobiological parameters is crucial to predicting radiation treatment response. Modeling differences may have a significant impact on derived parameters. In this study, the authors have integrated two existing models with kinetic differential equations to formulate a new tumor regression model for estimation of radiobiological parameters for individual patients. Methods: A system of differential equations that characterizes the birth-and-death process of tumor cells in radiation treatment was analytically solved. The solution of this system was used to construct an iterative model (Z-model). The model consists of three parameters: tumor doubling time T{sub d}, half-life of dead cells T{sub r}, and cell survival fraction SF{sub D} under dose D. The Jacobian determinant of this model was proposed as a constraint to optimize the three parameters for six head and neck cancer patients. The derived parameters were compared with those generated from the two existing models: Chvetsov's model (C-model) and Lim's model (L-model). The C-model and L-model were optimized with the parameter T{sub d} fixed. Results: With the Jacobian-constrained Z-model, the mean of the optimized cell survival fractions is 0.43 ± 0.08, and the half-life of dead cells averaged over the six patients is 17.5 ± 3.2 days. The parameters T{sub r} and SF{sub D} optimized with the Z-model differ by 1.2% and 20.3% from those optimized with the T{sub d}-fixed C-model, and by 32.1% and 112.3% from those optimized with the T{sub d}-fixed L-model, respectively. Conclusions: The Z-model was analytically constructed from the differential equations of cell populations that describe changes in the number of different tumor cells during the course of radiation treatment. The Jacobian constraints were proposed to optimize the three radiobiological parameters. The generated model and its optimization method may help develop high-quality treatment regimens for individual patients.

  8. Modification of radiobiological effects of 171 MeV protons by elements of physical protection

    NASA Astrophysics Data System (ADS)

    Bulinina, Taisia; Shurshakov, Vyacheslav; Ivanov, Alexander; Molokanov, Alexander

    2016-07-01

    Space radiation includes protons of various energies. Physical protection is effective in the case of low energy protons (50-100 MeV) and becomes insufficient for radiation with a high part of high-energy protons. In the experiment performed on outbred mice, the purpose of the study was to evaluate the radiobiological effect of 171 MeV protons and protons modified by elements of physical protection of the spacecraft, on a complex of indicators of the functional condition of the system hematopoiesis and the central nervous system in 24 hours after irradiation at 20 cGy dose. The spacecraft radiation protection elements used in the experiment were a construction of wet hygiene wipes called a «protective curtain», and a glass plate imitating an ISS window. Mass thickness of the " protective curtain" in terms of water equivalent was ̴ 6,2 g/cm2. Physical shielding along the path of 171 MeV protons increases their linear energy transfer leading to the absorbed dose elevation and strengthening of the radiobiological effect. In the experiment, the two types of shielding together raised the absorbed dose from 20 to 23.2 cGy. Chemically different materials (glass and water in the wipes) were found to exert unequal modifying effects on physical and biological parameters of the proton-irradiated mice. There was a distinct dose-dependent reduction of bone marrow cellularity within the dose range from 20 cGy to 23.2 cGy in 24 hours after exposure. No modifying effect of the radiation protection elements on spontaneous motor activity was discovered when compared with entrance protons. The group of animals protected by the glass plate exhibited normal orientative-trying reactions and weakened grip with the forelimbs. The effects observed in the experiment indicate the necessity to carry out comprehensive radiobiological researches (physical, biological and mathematical) in assessing the effects of physical protection, that are actual for ensuring radiation safety of crews in

  9. The Ethics of Archival Research

    ERIC Educational Resources Information Center

    McKee, Heidi A.; Porter, James E.

    2012-01-01

    What are the key ethical issues involved in conducting archival research? Based on examination of cases and interviews with leading archival researchers in composition, this article discusses several ethical questions and offers a heuristic to guide ethical decision making. Key to this process is recognizing the person-ness of archival materials.…

  10. Twitter Stream Archiver

    SciTech Connect

    Steed, Chad Allen

    2014-07-01

    The Twitter Archiver system allows a user to enter their Twitter developer account credentials (obtained separately from the Twitter developer website) and read from the freely available Twitter sample stream. The Twitter sample stream provides a random sample of the overall volume of tweets that are contributed by users to the system. The Twitter Archiver system consumes the stream and serializes the information to text files at some predefined interval. A separate utility reads the text files and creates a searchable index using the open source Apache Lucene text indexing system.

  11. Twitter Stream Archiver

    Energy Science and Technology Software Center (ESTSC)

    2014-07-01

    The Twitter Archiver system allows a user to enter their Twitter developer account credentials (obtained separately from the Twitter developer website) and read from the freely available Twitter sample stream. The Twitter sample stream provides a random sample of the overall volume of tweets that are contributed by users to the system. The Twitter Archiver system consumes the stream and serializes the information to text files at some predefined interval. A separate utility reads themore » text files and creates a searchable index using the open source Apache Lucene text indexing system.« less

  12. Web-based medical image archive system

    NASA Astrophysics Data System (ADS)

    Suh, Edward B.; Warach, Steven; Cheung, Huey; Wang, Shaohua A.; Tangiral, Phanidral; Luby, Marie; Martino, Robert L.

    2002-05-01

    This paper presents a Web-based medical image archive system in three-tier, client-server architecture for the storage and retrieval of medical image data, as well as patient information and clinical data. The Web-based medical image archive system was designed to meet the need of the National Institute of Neurological Disorders and Stroke for a central image repository to address questions of stroke pathophysiology and imaging biomarkers in stroke clinical trials by analyzing images obtained from a large number of clinical trials conducted by government, academic and pharmaceutical industry researchers. In the database management-tier, we designed the image storage hierarchy to accommodate large binary image data files that the database software can access in parallel. In the middle-tier, a commercial Enterprise Java Bean server and secure Web server manages user access to the image database system. User-friendly Web-interfaces and applet tools are provided in the client-tier for easy access to the image archive system over the Internet. Benchmark test results show that our three-tier image archive system yields fast system response time for uploading, downloading, and querying the image database.

  13. Heavy Charged Particle Radiobiology: Using Enhanced Biological Effectiveness and Improved Beam Focusing to Advance Cancer Therapy

    PubMed Central

    Allen, Christopher; Borak, Thomas B.; Tsujii, Hirohiko; Nickoloff, Jac A.

    2011-01-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation. PMID:21376738

  14. Radiobiological studies with the nematode Caenorhabditis elegans. Genetic and developmental effects of high LET radiation

    NASA Technical Reports Server (NTRS)

    Nelson, G. A.; Schubert, W. W.; Marshall, T. M.

    1992-01-01

    The biological effects of heavy charged particle (HZE) radiation are of particular interest to travellers and planners for long-duration space flights where exposure levels represent a potential health hazard. The unique feature of HZE radiation is the structured pattern of its energy deposition in targets. There are many consequences of this feature to biological endpoints when compared with effects of ionizing photons. Dose vs response and dose-rate kinetics may be modified, DNA and cellular repair systems may be altered in their abilities to cope with damage, and the qualitative features of damage may be unique for different ions. The nematode Caenorhabditis elegans is being used to address these and related questions associated with exposure to radiation. HZE-induced mutation, chromosome aberration, cell inactivation and altered organogenesis are discussed along with plans for radiobiological experiments in space.

  15. AFRRI (Armed Forces Radiobiology Research Institute) reports, July, August and September 1986. Technical report

    SciTech Connect

    Not Available

    1986-01-01

    Contents include: post-radiation regional cerebral blood flow in primates; heart-function studies in dogs after acute gamma irradiation of the precordium; the effect of anesthetic, sedative or narcotic drugs on intrahepatic and extrahepatic biliary kinetics; effect of gamma radiation on sodium channels in different conformations in neuroblastoma cells; effects of ethanol exposure on brain sodium channels; ionizing radiation alters the properties of sodium channels in rat brain synaptosomes; thymic hormones in thymus recovery from radiation injury; acute toxicity of petroleum- and shale-derived distillate fuel; light microscopic, hematologic, and serum chemistry studies; radioprotective properties of detoxified lipid A from Salmonella Minnesota R595; brain areas involved in production of morphine-induced locomotor hyperactivity of the C57B1/6J mouse; preliminary evaluation of US Army radiac detector DT-236/PD and radiac computer-indicator CP-696/UD; and calorimetric dose measurements and calorimetric system developed for the armed forces radiobiology research institute.

  16. Recent radiobiological findings from spaceflight and ground-based studies--an overview.

    PubMed

    Bucker, H; Facius, R

    1980-01-01

    With respect to radiation standards for manned space flight, we wish to address ourselves to the following topics that we consider pertinent for a realistic assessment of the risk to man when exposed to ionizing radiation under space flight conditions: 1) prediction and measurement of the spectra of the physical traits of cosmic radiation as a function of orbital parameters and the mass shielding of the spacecraft; 2) synergistic or antagonistic modification of radiation effects by dynamic flight conditions and by the space environment; 3) production of biological damage becoming manifest only long after exposure, especially to the heavy ions; and 4) demonstration of possibly specific radiobiological mechanisms for the densely ionizing heavy-ion component of the cosmic radiation. Some recent work referring to these topics will be presented and discussed with emphasis on the high LET component of the cosmic radiation. PMID:12197529

  17. Time resolving detector systems for radiobiological investigations of effects of single heavy ions

    SciTech Connect

    Schott, J.U. ||

    1993-12-31

    The combination of the properties of Charge Coupled Devices (CCDs) as image sensor and as detector for energetic charged particles makes them unique for time resolved radiation experiments in which single particles are to be correlated either to their radiation effects in individual objects, or to their sources or origins respectively. The experimental set up for the calibration of a frame transfer CCD type VALVO NXA 1011 with heavy ions from accelerators is described. For low energetic heavy ions, the single particle effects observed in the pixels of the sensor show a fairly linear response with the Linear Energy Transfer (LET) of the particle. As an example for the application of these detector systems in radiobiology, radiation effects of single ionizing particles in the meristem of moving biological objects have been investigated.

  18. Water versus DNA: new insights into proton track-structure modelling in radiobiology and radiotherapy

    NASA Astrophysics Data System (ADS)

    Champion, C.; Quinto, M. A.; Monti, J. M.; Galassi, M. E.; Weck, P. F.; Fojón, O. A.; Hanssen, J.; Rivarola, R. D.

    2015-10-01

    Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence—expressed in terms of total cross sections—as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies.

  19. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.

    PubMed

    Allen, Christopher; Borak, Thomas B; Tsujii, Hirohiko; Nickoloff, Jac A

    2011-06-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation. PMID:21376738

  20. Treatment plan comparison between helical tomotherapy and MLC-based IMRT using radiobiological measures

    NASA Astrophysics Data System (ADS)

    Mavroidis, Panayiotis; Costa Ferreira, Brigida; Shi, Chengyu; Lind, Bengt K.; Papanikolaou, Nikos

    2007-07-01

    The rapid implementation of advanced treatment planning and delivery technologies for radiation therapy has brought new challenges in evaluating the most effective treatment modality. Intensity-modulated radiotherapy (IMRT) using multi-leaf collimators (MLC) and helical tomotherapy (HT) are becoming popular modes of treatment delivery and their application and effectiveness continues to be investigated. Presently, there are several treatment planning systems (TPS) that can generate and optimize IMRT plans based on user-defined objective functions for the internal target volume (ITV) and organs at risk (OAR). However, the radiobiological parameters of the different tumours and normal tissues are typically not taken into account during dose prescription and optimization of a treatment plan or during plan evaluation. The suitability of a treatment plan is typically decided based on dosimetric criteria such as dose-volume histograms (DVH), maximum, minimum, mean and standard deviation of the dose distribution. For a more comprehensive treatment plan evaluation, the biologically effective uniform dose ({\\bar{\\bar{D}}}) is applied together with the complication-free tumour control probability (P+). Its utilization is demonstrated using three clinical cases that were planned with two different forms of IMRT. In this study, three different cancer types at different anatomical sites were investigated: head and neck, lung and prostate cancers. For each cancer type, a linac MLC-based step-and-shoot IMRT plan and a HT plan were developed. The MLC-based IMRT treatment plans were developed on the Philips treatment-planning platform, using the Pinnacle 7.6 software release. For the tomotherapy HiArt plans, the dedicated tomotherapy treatment planning station was used, running version 2.1.2. By using {\\bar{\\bar{D}}} as the common prescription point of the treatment plans and plotting the tissue response probabilities versus {\\bar{\\bar{D}}} for a range of prescription doses