40 CFR 408.143 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 30 2012-07-01 2012-07-01 false [Reserved] 408.143 Section 408.143 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Tuna Processing Subcategory § 408.143...

40 CFR 408.143 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 29 2011-07-01 2009-07-01 true [Reserved] 408.143 Section 408.143 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Tuna Processing Subcategory § 408.143...

33 CFR 143.300 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Applicability. 143.300 Section 143.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Vessels § 143.300 Applicability. This subpart applies to all...

33 CFR 143.300 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Applicability. 143.300 Section 143.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Vessels § 143.300 Applicability. This subpart applies to all...

33 CFR 143.300 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Applicability. 143.300 Section 143.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Vessels § 143.300 Applicability. This subpart applies to all...

14 CFR 1260.143 - Competition.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., Hospitals, and Other Non-Profit Organizations Procurement Standards § 1260.143 Competition. All procurement... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Competition. 1260.143 Section 1260.143... competition. The recipient shall be alert to organizational conflicts of interest as well as noncompetitive...

17 CFR 14.3 - Hearings.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Hearings. 14.3 Section 14.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES RELATING TO SUSPENSION OR DISBARMENT FROM APPEARANCE AND PRACTICE § 14.3 Hearings. Hearings required or permitted to be held under...

16 CFR 1.43 - Recommendations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Recommendations. 1.43 Section 1.43... PROCEDURES Export Trade Associations § 1.43 Recommendations. Whenever the Commission has reason to believe... association recommendations for the readjustment of its business. If the association fails to comply with the...

16 CFR 1.43 - Recommendations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Recommendations. 1.43 Section 1.43... PROCEDURES Export Trade Associations § 1.43 Recommendations. Whenever the Commission has reason to believe... association recommendations for the readjustment of its business. If the association fails to comply with the...

10 CFR 63.143 - Implementation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Implementation. 63.143 Section 63.143 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Quality Assurance § 63.143 Implementation. DOE shall implement a quality assurance program...

14 CFR 406.143 - Discovery.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Discovery. 406.143 Section 406.143... Transportation Adjudications § 406.143 Discovery. (a) Initiation of discovery. Any party may initiate discovery... after a complaint has been filed. (b) Methods of discovery. The following methods of discovery are...

14 CFR 406.143 - Discovery.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Discovery. 406.143 Section 406.143... Transportation Adjudications § 406.143 Discovery. (a) Initiation of discovery. Any party may initiate discovery... after a complaint has been filed. (b) Methods of discovery. The following methods of discovery are...

14 CFR 406.143 - Discovery.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Discovery. 406.143 Section 406.143... Transportation Adjudications § 406.143 Discovery. (a) Initiation of discovery. Any party may initiate discovery... after a complaint has been filed. (b) Methods of discovery. The following methods of discovery are...

14 CFR 406.143 - Discovery.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Discovery. 406.143 Section 406.143... Transportation Adjudications § 406.143 Discovery. (a) Initiation of discovery. Any party may initiate discovery... after a complaint has been filed. (b) Methods of discovery. The following methods of discovery are...

33 CFR 143.407 - Manning.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

33 CFR 143.407 - Manning.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

33 CFR 143.407 - Manning.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

33 CFR 143.407 - Manning.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed...

13 CFR 143.30 - Changes.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Changes. 143.30 Section 143.30... AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Changes, Property, and Subawards § 143.30 Changes. (a) General. Grantees and subgrantees are permitted to rebudget within...

14 CFR 406.143 - Discovery.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Discovery. 406.143 Section 406.143... Transportation Adjudications § 406.143 Discovery. (a) Initiation of discovery. Any party may initiate discovery... after a complaint has been filed. (b) Methods of discovery. The following methods of discovery are...

Synthesis of neodymium hydroxide nanotubes and nanorods by soft chemical process.

PubMed

Shi, Weidong; Yu, Jiangbo; Wang, Haishui; Yang, Jianhui; Zhang, Hongjie

2006-08-01

A facile soft chemical approach using cetyltrimethylammonium bromide (CTAB) as template is successfully designed for synthesis of neodymium hydroxide nanotubes. These nanotubes have an average outer diameter around 20 nm, inner diameter around 2 nm, and length ranging from 100 to 120 nm, high BET surface area of 495.71 m(2) g(-1). We also find that neodymium hydroxide nanorods would be obtained when CTAB absented in reaction system. The Nd(OH)3 nanorods might act as precursors that are converted into Nd2O3 nanorods through dehydration at 550 degrees C. The nanorods could exhibit upconversion emission characteristic under excitation of 591 nm at room temperature.

10 CFR 501.143 - Comments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Comments. 501.143 Section 501.143 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Rulings § 501.143 Comments. Any interested person may file a written comment on or objection to a published ruling at any time...

10 CFR 600.143 - Competition.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Competition. 600.143 Section 600.143 Energy DEPARTMENT OF... Nonprofit Organizations Post-Award Requirements § 600.143 Competition. All procurement transactions shall be conducted in a manner to provide, to the maximum extent practical, open and free competition. The recipient...

27 CFR 25.143 - Cases.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Cases. 25.143 Section 25.143 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Marks, Brands, and Labels § 25.143 Cases. (a) Brewer's name. The brewer's name or...

25 CFR 143.3 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Procedures. 143.3 Section 143.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES CHARGES FOR GOODS AND SERVICES PROVIDED TO NON-FEDERAL USERS § 143.3 Procedures. (a) All non-Federal users who receive the above listed goods/services...

25 CFR 143.4 - Charges.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Charges. 143.4 Section 143.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES CHARGES FOR GOODS AND SERVICES PROVIDED TO NON-FEDERAL USERS § 143.4 Charges. (a) Charges shall be established by the Assistant Secretary and shall be...

40 CFR 143.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECONDARY DRINKING WATER REGULATIONS § 143.2 Definitions. (a) Act means the Safe Drinking Water Act as... corrosion of piping and plumbing caused by water quality, are excluded from this definition. [44 FR 42198... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Definitions. 143.2 Section 143.2...

13 CFR 143.33 - Supplies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... residual inventory of unused supplies exceeding $5,000 in total aggregate fair market value upon... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Supplies. 143.33 Section 143.33..., and Subawards § 143.33 Supplies. (a) Title. Title to supplies acquired under a grant or subgrant will...

33 CFR 143.407 - Manning.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Manning. 143.407 Section 143.407 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.407 Manning. Standby vessels must be crewed in accordance with their certificate o...

Antioxidant protection mechanism of chick hepatic mitochondria exposed to lanthanum chloride & neodymium chloride treatment.

PubMed

Ghosh, N; Chattopadhyay, D; Chatterjee, G C

1991-05-01

Acute lanthanum chloride (250 mg/kg body wt) and neodymium chloride (200 mg/kg body wt) administrations resulted in significant enhancement of glutathione level in chick hepatic mitochondria. However, glutathione-s-transferase activity was depressed. There was no alteration in the activity of glutathione reductase. Activity of glucose-6-phosphate dehydrogenase was not altered under lanthanum and neodymium treatment. There was a significant enhancement of intramitochondrial glutathione peroxidase and superoxide dismutase. Lipid peroxidation remains the same as control group of animals.

Neodymium: YAG lasers. An FDA report.

PubMed

Stark, W J; Worthen, D; Holladay, J T; Murray, G

1985-02-01

Analysis of data from four neodymium:YAG laser manufacturers submitted to the Food and Drug Administration (FDA) on over 17,000 cases indicate the procedure is safe and effective for cutting opaque posterior lens capsules. A successful opening in the pupillary membrane was achieved in 98% of the cases, and vision improved in 84% of the cases. Clinically significant risks include: a rise in intraocular pressure two to four hours after treatment, damage to the intraocular lens, and rupture of the anterior hyaloid face.

22 CFR 143.24 - Information requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Information requirements. 143.24 Section 143.24... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 143.24 Information requirements. Each recipient shall: (a) Make available upon request to the agency information necessary to...

Neodymium:YAG laser cutting of intraocular lens haptics.

PubMed

Gorn, R A; Steinert, R F

1985-11-01

Neodymium:YAG laser cutting of polymethylmethacrylate and polypropylene anterior chamber and posterior chamber intraocular lens haptics was studied in terms of ease of transection and physical structure of the cut areas as seen by scanning electron microscopy. A marked difference was discovered, with the polymethylmethacrylate cutting easily along transverse planes, whereas the polypropylene resisted cutting along longitudinal fibers. Clinical guidelines are presented.

33 CFR 117.143 - Bishop Cut.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Bishop Cut. 117.143 Section 117.143 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements California § 117.143 Bishop Cut. The draw of the San Joaquin...

33 CFR 117.143 - Bishop Cut.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bishop Cut. 117.143 Section 117.143 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements California § 117.143 Bishop Cut. The draw of the San Joaquin...

13 CFR 143.31 - Real property.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Real property. 143.31 Section 143..., Property, and Subawards § 143.31 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon...

13 CFR 143.31 - Real property.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Real property. 143.31 Section 143..., Property, and Subawards § 143.31 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon...

13 CFR 143.31 - Real property.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Real property. 143.31 Section 143..., Property, and Subawards § 143.31 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon...

13 CFR 143.31 - Real property.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Real property. 143.31 Section 143..., Property, and Subawards § 143.31 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon...

13 CFR 143.31 - Real property.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Real property. 143.31 Section 143..., Property, and Subawards § 143.31 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title to real property acquired under a grant or subgrant will vest upon...

46 CFR 108.143 - Accommodation space.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Accommodation space. 108.143 Section 108.143 Shipping... EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.143 Accommodation space. (a) Each corridor bulkhead in an accommodation space must be an A class or B class bulkhead except if an A class...

46 CFR 108.143 - Accommodation space.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Accommodation space. 108.143 Section 108.143 Shipping... EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.143 Accommodation space. (a) Each corridor bulkhead in an accommodation space must be an A class or B class bulkhead except if an A class...

46 CFR 108.143 - Accommodation space.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Accommodation space. 108.143 Section 108.143 Shipping... EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.143 Accommodation space. (a) Each corridor bulkhead in an accommodation space must be an A class or B class bulkhead except if an A class...

46 CFR 108.143 - Accommodation space.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Accommodation space. 108.143 Section 108.143 Shipping... EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.143 Accommodation space. (a) Each corridor bulkhead in an accommodation space must be an A class or B class bulkhead except if an A class...

46 CFR 108.143 - Accommodation space.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Accommodation space. 108.143 Section 108.143 Shipping... EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.143 Accommodation space. (a) Each corridor bulkhead in an accommodation space must be an A class or B class bulkhead except if an A class...

Isotope enrichment by frequency-tripled temperature tuned neodymium laser photolysis of formaldehyde

DOEpatents

Marling, John B.

1977-01-01

Enrichment of carbon, hydrogen and/or oxygen isotopes by means of isotopically selective photo-predissociation of formaldehyde is achieved by irradiation provided by a frequency-tripled, temperature tuned neodymium laser.

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosal, Blanca del; Pérez-Delgado, Alberto; Rocha, Ueslen

2015-10-14

The spectroscopic properties of different infrared-emitting neodymium-doped nanoparticles (LaF{sub 3}:Nd{sup 3+}, SrF{sub 2}:Nd{sup 3+}, NaGdF{sub 4}: Nd{sup 3+}, NaYF{sub 4}: Nd{sup 3+}, KYF{sub 4}: Nd{sup 3+}, GdVO{sub 4}: Nd{sup 3+}, and Nd:YAG) have been systematically analyzed. A comparison of the spectral shapes of both emission and absorption spectra is presented, from which the relevant role played by the host matrix is evidenced. The lack of a “universal” optimum system for infrared bioimaging is discussed, as the specific bioimaging application and the experimental setup for infrared imaging determine the neodymium-doped nanoparticle to be preferentially used in each case.

14 CFR 25.143 - General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false General. 25.143 Section 25.143 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... control forces permitted during the testing required by paragraph (a) through (c) of this section: Force...

14 CFR 23.143 - General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false General. 23.143 Section 23.143 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... conditions exist with regard to required pilot strength, the control forces necessary must be determined by...

14 CFR 23.143 - General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false General. 23.143 Section 23.143 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... conditions exist with regard to required pilot strength, the control forces necessary must be determined by...

14 CFR 23.143 - General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false General. 23.143 Section 23.143 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... conditions exist with regard to required pilot strength, the control forces necessary must be determined by...

13 CFR 143.21 - Payment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Payment. 143.21 Section 143.21 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS... period generally geared to the grantee's disbursing cycle. Thereafter, the awarding agency shall...

13 CFR 143.36 - Procurement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Procurement. 143.36 Section 143.36 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS... will be responsible, in accordance with good administrative practice and sound business judgment, for...

33 CFR 211.143 - Delegations.

Code of Federal Regulations, 2011 CFR

2011-07-01

....143 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Conveyances for Public Port Or Industrial Facilities § 211.143 Delegations. (a) The Chief of Engineers and/or the...

33 CFR 211.143 - Delegations.

Code of Federal Regulations, 2010 CFR

2010-07-01

....143 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Conveyances for Public Port Or Industrial Facilities § 211.143 Delegations. (a) The Chief of Engineers and/or the...

27 CFR 28.143 - Containers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Containers. 28.143 Section....143 Containers. (a) Beer. Beer being exported, used as supplies on vessels and aircraft, or..., or bulk containers. (b) Beer concentrate. Concentrate may not be removed for export, or for transfer...

19 CFR 143.2 - Application.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Application. 143.2 Section 143.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... description of the computer hardware, communications and entry processing systems to be used and the estimated...

19 CFR 143.2 - Application.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 2 2014-04-01 2014-04-01 false Application. 143.2 Section 143.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... description of the computer hardware, communications and entry processing systems to be used and the estimated...

19 CFR 143.2 - Application.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 2 2012-04-01 2012-04-01 false Application. 143.2 Section 143.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... description of the computer hardware, communications and entry processing systems to be used and the estimated...

19 CFR 143.2 - Application.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 2 2013-04-01 2013-04-01 false Application. 143.2 Section 143.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... description of the computer hardware, communications and entry processing systems to be used and the estimated...

19 CFR 143.2 - Application.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Application. 143.2 Section 143.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY... description of the computer hardware, communications and entry processing systems to be used and the estimated...

13 CFR 143.44 - Termination for convenience.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Termination for convenience. 143.44 Section 143.44 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION UNIFORM ADMINISTRATIVE... Reports, Records, Retention, and Enforcement § 143.44 Termination for convenience. Except as provided in...

49 CFR 37.143 - Paratransit plan implementation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Paratransit plan implementation. 37.143 Section 37.143 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.143 Paratransit plan...

Nanostructured silicon ferromagnet collected by a permanent neodymium magnet.

PubMed

Okuno, Takahisa; Thürmer, Stephan; Kanoh, Hirofumi

2017-11-30

Nanostructured silicon (N-Si) was prepared by anodic electroetching of p-type silicon wafers. The obtained magnetic particles were separated by a permanent neodymium magnet as a magnetic nanostructured silicon (mN-Si). The N-Si and mN-Si exhibited different magnetic properties: the N-Si exhibited ferromagnetic-like behaviour, whereas the mN-Si exhibited superparamagnetic-like behaviour.

32 CFR 143.8 - Guidelines.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Guidelines. 143.8 Section 143.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN DOD POLICY ON... with the Department of Defense needed to make the determinations required by this part shall be...

32 CFR 143.8 - Guidelines.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Guidelines. 143.8 Section 143.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN DOD POLICY ON... with the Department of Defense needed to make the determinations required by this part shall be...

32 CFR 143.8 - Guidelines.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Guidelines. 143.8 Section 143.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN DOD POLICY ON... with the Department of Defense needed to make the determinations required by this part shall be...

32 CFR 143.8 - Guidelines.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Guidelines. 143.8 Section 143.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN DOD POLICY ON... with the Department of Defense needed to make the determinations required by this part shall be...

25 CFR 143.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Definitions. 143.1 Section 143.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES CHARGES FOR GOODS AND SERVICES PROVIDED TO NON... costs incurred by the Government for the goods/services being provided. (d) Non-Federal users are...

32 CFR 143.7 - Responsibilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Responsibilities. 143.7 Section 143.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN DOD... concerned. (3) Report any action initiated under this part immediately to the Secretary of Defense. (b) The...

32 CFR 143.7 - Responsibilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Responsibilities. 143.7 Section 143.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN DOD... concerned. (3) Report any action initiated under this part immediately to the Secretary of Defense. (b) The...

32 CFR 143.7 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Responsibilities. 143.7 Section 143.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN DOD... concerned. (3) Report any action initiated under this part immediately to the Secretary of Defense. (b) The...

32 CFR 143.7 - Responsibilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Responsibilities. 143.7 Section 143.7 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN DOD... concerned. (3) Report any action initiated under this part immediately to the Secretary of Defense. (b) The...

22 CFR 143.33 - Mediation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Mediation. 143.33 Section 143.33 Foreign... Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and... participate in the mediation process to the extent necessary to reach an agreement or make an informed...

22 CFR 143.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Definitions. 143.3 Section 143.3 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES...) As used in this part: (1) Agency means the Department of State, the U.S. International Communication...

7 CFR 762.143 - Servicing distressed accounts.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 7 2014-01-01 2014-01-01 false Servicing distressed accounts. 762.143 Section 762.143 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GUARANTEED FARM LOANS § 762.143 Servicing distressed accounts. (a) A borrower is...

12 CFR 313.143 - Cancellation of deduction.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Cancellation of deduction. 313.143 Section 313.143 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PROCEDURES FOR CORPORATE DEBT COLLECTION Civil Service Retirement and Disability Fund Offset § 313.143...

7 CFR 58.143 - Raw product storage.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Raw product storage. 58.143 Section 58.143 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.143 Raw product storage. (a) All milk shall be held and processed under conditions and at...

7 CFR 58.143 - Raw product storage.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false Raw product storage. 58.143 Section 58.143 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.143 Raw product storage. (a) All milk shall be held and processed under conditions and at...

19 CFR 143.4 - Confidentiality of data.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Confidentiality of data. 143.4 Section 143.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.4 Confidentiality of data...

22 CFR 143.22 - Notice to subrecipients.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Notice to subrecipients. 143.22 Section 143.22 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 143.22 Notice to...

22 CFR 143.22 - Notice to subrecipients.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Notice to subrecipients. 143.22 Section 143.22 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 143.22 Notice to...

22 CFR 143.22 - Notice to subrecipients.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Notice to subrecipients. 143.22 Section 143.22 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 143.22 Notice to...

22 CFR 143.22 - Notice to subrecipients.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Notice to subrecipients. 143.22 Section 143.22 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 143.22 Notice to...

22 CFR 143.22 - Notice to subrecipients.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Notice to subrecipients. 143.22 Section 143.22 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 143.22 Notice to...

19 CFR 143.4 - Confidentiality of data.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Confidentiality of data. 143.4 Section 143.4... TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.4 Confidentiality of data. The electronic data received and exchanged by a service bureau shall be considered confidential, and...

19 CFR 143.3 - Action on application.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Action on application. 143.3 Section 143.3 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.3 Action on application. (a) Approval...

7 CFR 1.143 - Motions and requests.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Contents. All written motions and requests shall state the particular order, ruling, or action desired and... 7 Agriculture 1 2010-01-01 2010-01-01 false Motions and requests. 1.143 Section 1.143 Agriculture... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.143 Motions and requests. (a...

7 CFR 1.143 - Motions and requests.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Contents. All written motions and requests shall state the particular order, ruling, or action desired and... 7 Agriculture 1 2011-01-01 2011-01-01 false Motions and requests. 1.143 Section 1.143 Agriculture... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.143 Motions and requests. (a...

Microscale Demonstration of the Paramagnetism of Liquid Oxygen with a Neodymium Magnet

ERIC Educational Resources Information Center

Mattson, Bruce

2007-01-01

A microscale classroom demonstration of the paramagnetic behavior of various samples of liquid oxygen with neodymium magnet is being presented. The experiment should be done with extreme caution, as liquid oxygen reacts violently with organic matters.

Demonstrating and Measuring Relative Molar Magnetic Susceptibility Using a Neodymium Magnet

ERIC Educational Resources Information Center

Malerich, Charles; Ruff, Patricia K.; Bird, Aubrey

2004-01-01

An easy-to-see method for demonstrating and measuring the magnetic force between paramagnetic substance and a rare earth magnet is presented. The readily available trapezoid-shaped neodymium magnet and a low cost, easy-to-set-up, portable apparatus are used in the experiments.

Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.

PubMed

Liu, Jianbo; Li, Min; Wang, Yuewei; Luo, Jianchao

2017-08-01

Curcumin has been reported as a radiosensitizer in prostate cancer. But the underlying mechanism is not well understood. In this study, we firstly assessed how curcumin affects the expression of miR-143/miR-145 cluster. Then, we investigated whether miR-143 is involved in regulation of radiosensitivity and its association with autophagy in prostate cancer cells. Our data showed that PC3, DU145 and LNCaP cells treated with curcumin had significantly restored miR-143 and miR-145 expression. Curcumin showed similar effect as 5-AZA-dC on reducing methylation of CpG dinucleotides in miR-143 promoter. In addition, curcumin treatment reduced the expression of DNMT1 and DNMT3B, which contribute to promoter hypermethylation of the miR-143/miR-145 cluster. Therefore, we infer that curcumin can restore miR-143 and miR-145 expression via hypomethylation. MiR-143 overexpression and curcumin pretreatment enhanced radiation induced cancer cell growth inhibition and apoptosis. MiR-143 and curcumin remarkably reduced radiation-induced autophagy in PC3 and DU145 cells. MiR-143 overexpression alone also reduced the basal level of autophagy in DU145 cells. Mechanistically, miR-143 can suppress autophagy in prostate cancer cells at least via downregulating ATG2B. Based on these findings, we infer that curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.

7 CFR 97.143 - Certified seed only.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false Certified seed only. 97.143 Section 97.143 Agriculture... PLANT VARIETY AND PROTECTION Marking Or Labeling Provisions § 97.143 Certified seed only. (a) Upon filing an application, or amendment thereto, specifying seed of the variety is to be sold by variety name...

7 CFR 97.143 - Certified seed only.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Certified seed only. 97.143 Section 97.143 Agriculture... PLANT VARIETY AND PROTECTION Marking Or Labeling Provisions § 97.143 Certified seed only. (a) Upon filing an application, or amendment thereto, specifying seed of the variety is to be sold by variety name...

27 CFR 9.143 - Spring Mountain District.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Spring Mountain District. 9.143 Section 9.143 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.143 Spring Mountain District. (a) Name. The...

27 CFR 9.143 - Spring Mountain District.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Spring Mountain District. 9.143 Section 9.143 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.143 Spring Mountain District. (a) Name. The...

27 CFR 9.143 - Spring Mountain District.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Spring Mountain District. 9.143 Section 9.143 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.143 Spring Mountain District. (a) Name. The...

27 CFR 9.143 - Spring Mountain District.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Spring Mountain District. 9.143 Section 9.143 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.143 Spring Mountain District. (a) Name. The...

27 CFR 9.143 - Spring Mountain District.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Spring Mountain District. 9.143 Section 9.143 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.143 Spring Mountain District. (a) Name. The...

7 CFR 58.143 - Raw product storage.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false Raw product storage. 58.143 Section 58.143 Agriculture... Procedures § 58.143 Raw product storage. (a) All milk shall be held and processed under conditions and at... source shall not be used for the manufacture of dairy products. Bulk milk in storage tanks within the...

7 CFR 58.143 - Raw product storage.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 3 2014-01-01 2014-01-01 false Raw product storage. 58.143 Section 58.143 Agriculture... Procedures § 58.143 Raw product storage. (a) All milk shall be held and processed under conditions and at... source shall not be used for the manufacture of dairy products. Bulk milk in storage tanks within the...

40 CFR 143.3 - Secondary maximum contaminant levels.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... 143.3 Section 143.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL SECONDARY DRINKING WATER REGULATIONS § 143.3 Secondary maximum contaminant levels. The secondary maximum contaminant levels for public water systems are as follows: Contaminant...

40 CFR 143.3 - Secondary maximum contaminant levels.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... 143.3 Section 143.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL SECONDARY DRINKING WATER REGULATIONS § 143.3 Secondary maximum contaminant levels. The secondary maximum contaminant levels for public water systems are as follows: Contaminant...

40 CFR 143.3 - Secondary maximum contaminant levels.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... 143.3 Section 143.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL SECONDARY DRINKING WATER REGULATIONS § 143.3 Secondary maximum contaminant levels. The secondary maximum contaminant levels for public water systems are as follows: Contaminant...

40 CFR 143.3 - Secondary maximum contaminant levels.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... 143.3 Section 143.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL SECONDARY DRINKING WATER REGULATIONS § 143.3 Secondary maximum contaminant levels. The secondary maximum contaminant levels for public water systems are as follows: Contaminant...

7 CFR 1703.143 - Maximum and minimum amounts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Maximum and minimum amounts. 1703.143 Section 1703.143 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.143...

7 CFR 1703.143 - Maximum and minimum amounts.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 11 2012-01-01 2012-01-01 false Maximum and minimum amounts. 1703.143 Section 1703.143 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.143...

7 CFR 1703.143 - Maximum and minimum amounts.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 11 2013-01-01 2013-01-01 false Maximum and minimum amounts. 1703.143 Section 1703.143 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.143...

7 CFR 1703.143 - Maximum and minimum amounts.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 11 2014-01-01 2014-01-01 false Maximum and minimum amounts. 1703.143 Section 1703.143 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.143...

7 CFR 1703.143 - Maximum and minimum amounts.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 11 2011-01-01 2011-01-01 false Maximum and minimum amounts. 1703.143 Section 1703.143 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.143...

[Neodymium magnet injury causing nasal fracture: a case report].

PubMed

Aykan, Andaç; Güzey, Serbülent; Avşar, Sedat; Öztürk, Serdar

2015-05-01

In parallel with technological developments, small size but strong magnets are commonly used in modern devices. In terms of foreign body injuries, magnet injuries are quite rare. However, due to their unique characteristics, there are some difficulties in their management. The magnetic field generated by the magnet affects the surgical instruments and make treatment difficult. In this case report, a nasal injury due to neodymium magnet and our alternative approach for its management was reported.

13 CFR 143.41 - Financial reporting.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Financial reporting. 143.41... Reports, Records, Retention, and Enforcement § 143.41 Financial reporting. (a) General. (1) Except as... authorized by OMB, for: (i) Submitting financial reports to Federal agencies, or (ii) Requesting advances or...

33 CFR 143.105 - Personnel landings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Personnel landings. 143.105...) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT OCS Facilities § 143.105 Personnel landings. (a) Sufficient personnel landings shall be provided on each manned OCS facility to assure safe access and egress...

33 CFR 143.105 - Personnel landings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Personnel landings. 143.105...) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT OCS Facilities § 143.105 Personnel landings. (a) Sufficient personnel landings shall be provided on each manned OCS facility to assure safe access and egress...

13 CFR 143.41 - Financial reporting.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Financial reporting. 143.41... Reports, Records, Retention, and Enforcement § 143.41 Financial reporting. (a) General. (1) Except as... authorized by OMB, for: (i) Submitting financial reports to Federal agencies, or (ii) Requesting advances or...

X-ray emission from a plasma mirror of a neodymium glass laser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalal, M.; Pina, L.; Vrbova, M.

1984-11-01

An investigation was made of the optical and x-ray characteristics of the radiation emitted by a plasma mirror in a neodymium glass laser. The optical reflection coefficient of the mirror was found to be nonlinear and the plasma temperature was about 300 eV.

Lattice thermal expansion and solubility limits of neodymium-doped ceria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Jinhua, E-mail: jhzhang1212@126.com; State Key laboratory of Geological Process and Mineral Resources, China University of Geosciences, Wuhan 430074; Ke, Changming

2016-11-15

Nd{sub x}Ce{sub 1−x}O{sub 2−0.5x} (x=0–1.0) powders were prepared by reverse coprecipitation-calcination method and characterized by XRD. The crystal structure of product powders transformed from single fluorite structure to the complex of fluorite and C-type cubic structure, and finally to trigonal structure with the increase of x-value. An empirical equation simulating the lattice parameter of neodymium doped ceria was established based on the experimental data. The lattice parameters of the fluorite structure solid solutions increased with extensive adoption of Nd{sup 3+}, and the heating temperature going up. The average thermal expansion coefficients of neodymium doped ceria with fluorite structure are highermore » than 13.5×10{sup −6} °C{sup −1} from room temperature to 1200 °C. - Graphical abstract: The crystal structure of Nd{sub x}Ce{sub 1−x}O{sub 2−0.5x} (x=0–1.0) powders transformed from single fluorite structure to the complex of fluorite and C-type cubic structure, and finally to trigonal structure with the increase of x-value.« less

13 CFR 143.5 - Effect on other issuances.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Effect on other issuances. 143.5 Section 143.5 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS General § 143.5 Effect on...

19 CFR 143.7 - Revocation of ABI participation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Revocation of ABI participation. 143.7 Section 143.7 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.7 Revocation of ABI...

A green separation strategy for neodymium (III) from cobalt (II) and nickel (II) using an ionic liquid-based aqueous two-phase system.

PubMed

Chen, Yuehua; Wang, Huiyong; Pei, Yuanchao; Wang, Jianji

2018-05-15

It is significant to develop sustainable strategies for the selective separation of rare earth from transition metals from fundamental and practical viewpoint. In this work, an environmentally friendly solvent extraction approach has been developed to selectively separate neodymium (III) from cobalt (II) and nickel (II) by using an ionic liquid-based aqueous two phase system (IL-ATPS). For this purpose, a hydrophilic ionic liquid (IL) tetrabutylphosphonate nitrate ([P 4444 ][NO 3 ]) was prepared and used for the formation of an ATPS with NaNO 3 . Binodal curves of the ATPSs have been determined for the design of extraction process. The extraction parameters such as contact time, aqueous phase pH, content of phase-formation components of NaNO 3 and the ionic liquid have been investigated systematically. It is shown that under optimal conditions, the extraction efficiency of neodymium (III) is as high as 99.7%, and neodymium (III) can be selectively separated from cobalt (II) and nickel (II) with a separation factor of 10 3 . After extraction, neodymium (III) can be stripped from the IL-rich phase by using dilute aqueous sodium oxalate, and the ILs can be quantitatively recovered and reused in the next extraction process. Since [P 4444 ][NO 3 ] works as one of the components of the ATPS and the extractant for the neodymium, no organic diluent, extra etractant and fluorinated ILs are used in the separation process. Thus, the strategy described here shows potential in green separation of neodymium from cobalt and nickel by using simple IL-based aqueous two-phase system. Copyright © 2018 Elsevier B.V. All rights reserved.

29 CFR 500.143 - Civil money penalty assessment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Civil money penalty assessment. 500.143 Section 500.143... MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Enforcement § 500.143 Civil money penalty assessment. (a) A civil money penalty may be assessed for each violation of the Act or these regulations. (b) In...

29 CFR 500.143 - Civil money penalty assessment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Civil money penalty assessment. 500.143 Section 500.143... MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Enforcement § 500.143 Civil money penalty assessment. (a) A civil money penalty may be assessed for each violation of the Act or these regulations. (b) In...

29 CFR 500.143 - Civil money penalty assessment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Civil money penalty assessment. 500.143 Section 500.143... MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Enforcement § 500.143 Civil money penalty assessment. (a) A civil money penalty may be assessed for each violation of the Act or these regulations. (b) In...

29 CFR 500.143 - Civil money penalty assessment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Civil money penalty assessment. 500.143 Section 500.143... MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Enforcement § 500.143 Civil money penalty assessment. (a) A civil money penalty may be assessed for each violation of the Act or these regulations. (b) In...

29 CFR 500.143 - Civil money penalty assessment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Civil money penalty assessment. 500.143 Section 500.143... MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Enforcement § 500.143 Civil money penalty assessment. (a) A civil money penalty may be assessed for each violation of the Act or these regulations. (b) In...

10 CFR 52.143 - Staff approval of design.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Staff approval of design. 52.143 Section 52.143 Energy... Standard Design Approvals § 52.143 Staff approval of design. Upon completion of its review of a submittal....141 of this subpart, the NRC staff shall publish a determination in the Federal Register as to whether...

10 CFR 52.143 - Staff approval of design.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Staff approval of design. 52.143 Section 52.143 Energy... Standard Design Approvals § 52.143 Staff approval of design. Upon completion of its review of a submittal....141 of this subpart, the NRC staff shall publish a determination in the Federal Register as to whether...

10 CFR 52.143 - Staff approval of design.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Staff approval of design. 52.143 Section 52.143 Energy... Standard Design Approvals § 52.143 Staff approval of design. Upon completion of its review of a submittal....141 of this subpart, the NRC staff shall publish a determination in the Federal Register as to whether...

10 CFR 52.143 - Staff approval of design.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Staff approval of design. 52.143 Section 52.143 Energy... Standard Design Approvals § 52.143 Staff approval of design. Upon completion of its review of a submittal....141 of this subpart, the NRC staff shall publish a determination in the Federal Register as to whether...

10 CFR 52.143 - Staff approval of design.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Staff approval of design. 52.143 Section 52.143 Energy... Standard Design Approvals § 52.143 Staff approval of design. Upon completion of its review of a submittal....141 of this subpart, the NRC staff shall publish a determination in the Federal Register as to whether...

High surface area neodymium phosphate nano particles by modified aqueous sol-gel method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sankar, Sasidharan; Warrier, Krishna Gopakumar, E-mail: wwarrierkgk@yahoo.co.in; Komban, Rajesh

2011-12-15

Graphical abstract: Synthesis of nano rod shaped neodymium phosphate particles with specific surface area as high as 107 m{sup 2} g{sup -1} and particles could be compacted and sintered at as low as 1300 Degree-Sign C to a density of 98.5% (theoretical) with an average grain size of {approx}1 {mu}m. Highlights: Black-Right-Pointing-Pointer Nano size neodymium phosphate is synthesized and characterized using a novel modified aqueous sol gel process. Black-Right-Pointing-Pointer Specific surface area above 100 m{sup 2} g{sup -1} achieved without the addition of any complexing agents. Black-Right-Pointing-Pointer High sintered density reported than the density obtained for powder synthesized through conventionalmore » solid state reaction. Black-Right-Pointing-Pointer The particles are nano sized and have rod shape morphology and are retained at higher temperatures. Black-Right-Pointing-Pointer An average grain size of {approx}1 {mu}m obtained for sintered NdPO{sub 4} after thermal etching at 1400 Degree-Sign C. -- Abstract: Synthesis of nano rod shaped neodymium phosphate (NdPO{sub 4}) particles with specific surface area as high as 107 m{sup 2}g{sup -1} and an average length of 50 nm with aspect ratio 5 was achieved using modified sol gel method. Crystallite size calculated from the X-ray diffraction data by applying Scherer equation was 5 nm for the precursor gel after calcination at 400 Degree-Sign C. NdPO{sub 4} was first precipitated from neodymium nitrate solution using phosphoric acid followed by peptization using dilute nitric acid and further gelation in ammonia atmosphere. The calcined gel powders were further characterized by surface area (Brunauer-Emmet-Teller nitrogen adsorption analysis), Transmission electron microscopy, scanning electron microscopy, UV-vis and FT-IR analysis. Transmission electron microscopy confirms the formation of rod like morphology from the sol, gel and the calcined particles in nano size range. These particles could be

The neodymium stable isotope composition of the silicate Earth and chondrites

NASA Astrophysics Data System (ADS)

McCoy-West, Alex J.; Millet, Marc-Alban; Burton, Kevin W.

2017-12-01

The non-chondritic neodymium (Nd) 142Nd/144Nd ratio of the silicate Earth potentially provides a key constraint on the accretion and early evolution of the Earth. Yet, it is debated whether this offset is due to the Earth being formed from material enriched in s-process Nd isotopes or results from an early differentiation process such as the segregation of a late sulfide matte during core formation, collisional erosion or a some combination of these processes. Neodymium stable isotopes are potentially sensitive to early sulfide segregation into Earth's core, a process that cannot be resolved using their radiogenic counterparts. This study presents the first comprehensive Nd stable isotope data for chondritic meteorites and terrestrial rocks. Stable Nd measurements were made using a double spike technique coupled with thermal ionisation mass spectrometry. All three of the major classes of chondritic meteorites, carbonaceous, enstatite and ordinary chondrites have broadly similar isotopic compositions allowing calculation of a chondritic mean of δ146/144Nd = -0.025 ± 0.025‰ (±2 s.d.; n = 39). Enstatite chondrites yield the most uniform stable isotope composition (Δ146/144Nd = 26 ppm), with considerably more variability observed within ordinary (Δ146/144Nd = 72 ppm) and carbonaceous meteorites (Δ146/144Nd = 143 ppm). Terrestrial weathering, nucleosynthetic variations and parent body thermal metamorphism appear to have little measurable effect on δ146/144Nd in chondrites. The small variations observed between ordinary chondrite groups most likely reflect inherited compositional differences between parent bodies, with the larger variations observed in carbonaceous chondrites being linked to varying modal proportions of calcium-aluminium rich inclusions. The terrestrial samples analysed here include rocks ranging from basaltic to rhyolitic in composition, MORB glasses and residual mantle lithologies. All of these terrestrial rocks possess a broadly similar Nd

26 CFR 1.143(g)-1 - Requirements related to arbitrage.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Requirements related to arbitrage. 1.143(g)-1 Section 1.143(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED....143(g)-1 Requirements related to arbitrage. (a) In general. Under section 143, for an issue to be an...

26 CFR 1.143(g)-1 - Requirements related to arbitrage.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Requirements related to arbitrage. 1.143(g)-1 Section 1.143(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED....143(g)-1 Requirements related to arbitrage. (a) In general. Under section 143, for an issue to be an...

26 CFR 1.143(g)-1 - Requirements related to arbitrage.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Requirements related to arbitrage. 1.143(g)-1 Section 1.143(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED....143(g)-1 Requirements related to arbitrage. (a) In general. Under section 143, for an issue to be an...

26 CFR 1.143(g)-1 - Requirements related to arbitrage.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Requirements related to arbitrage. 1.143(g)-1 Section 1.143(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED....143(g)-1 Requirements related to arbitrage. (a) In general. Under section 143, for an issue to be an...

26 CFR 1.143(g)-1 - Requirements related to arbitrage.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Requirements related to arbitrage. 1.143(g)-1 Section 1.143(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED....143(g)-1 Requirements related to arbitrage. (a) In general. Under section 143, for an issue to be an...

36 CFR 223.143 - Procedures for suspension.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Procedures for suspension. 223.143 Section 223.143 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

36 CFR 223.143 - Procedures for suspension.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Procedures for suspension. 223.143 Section 223.143 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

36 CFR 223.143 - Procedures for suspension.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Procedures for suspension. 223.143 Section 223.143 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

36 CFR 223.143 - Procedures for suspension.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Procedures for suspension. 223.143 Section 223.143 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

34 CFR 300.143 - Separate classes prohibited.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Separate classes prohibited. 300.143 Section 300.143 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

19 CFR 143.8 - Appeal of suspension or revocation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Appeal of suspension or revocation. 143.8 Section 143.8 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.8 Appeal of...

19 CFR 143.6 - Failure to maintain performance standards.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Failure to maintain performance standards. 143.6 Section 143.6 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.6 Failure to...

46 CFR 45.143 - Hull openings above freeboard deck.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Hull openings above freeboard deck. 45.143 Section 45.143 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Conditions of Assignment § 45.143 Hull openings above freeboard deck. Closures for openings above...

10 CFR 1.43 - Office of Nuclear Reactor Regulation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Office of Nuclear Reactor Regulation. 1.43 Section 1.43 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.43 Office of Nuclear Reactor Regulation. The Office of Nuclear Reactor Regulation— (a...

10 CFR 1.43 - Office of Nuclear Reactor Regulation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Office of Nuclear Reactor Regulation. 1.43 Section 1.43 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.43 Office of Nuclear Reactor Regulation. The Office of Nuclear Reactor Regulation— (a...

10 CFR 1.43 - Office of Nuclear Reactor Regulation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Office of Nuclear Reactor Regulation. 1.43 Section 1.43 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.43 Office of Nuclear Reactor Regulation. The Office of Nuclear Reactor Regulation— (a...

10 CFR 1.43 - Office of Nuclear Reactor Regulation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Office of Nuclear Reactor Regulation. 1.43 Section 1.43 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.43 Office of Nuclear Reactor Regulation. The Office of Nuclear Reactor Regulation— (a...

10 CFR 1.43 - Office of Nuclear Reactor Regulation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Office of Nuclear Reactor Regulation. 1.43 Section 1.43 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.43 Office of Nuclear Reactor Regulation. The Office of Nuclear Reactor Regulation— (a...

19 CFR 143.5 - System performance requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 2 2012-04-01 2012-04-01 false System performance requirements. 143.5 Section 143.5 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... must demonstrate that his system can interface directly with the Customs computer and ensure accurate...

19 CFR 143.5 - System performance requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false System performance requirements. 143.5 Section 143.5 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... must demonstrate that his system can interface directly with the Customs computer and ensure accurate...

19 CFR 143.5 - System performance requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 2 2014-04-01 2014-04-01 false System performance requirements. 143.5 Section 143.5 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... must demonstrate that his system can interface directly with the Customs computer and ensure accurate...

19 CFR 143.5 - System performance requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false System performance requirements. 143.5 Section 143.5 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... must demonstrate that his system can interface directly with the Customs computer and ensure accurate...

19 CFR 143.5 - System performance requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 2 2013-04-01 2013-04-01 false System performance requirements. 143.5 Section 143.5 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... must demonstrate that his system can interface directly with the Customs computer and ensure accurate...

Neodymium:yttrium-aluminum-garnet laser fusion of endarterectomy flaps.

PubMed

Humphrey, P W; Slocum, M M; Loy, T S; Silver, D

1995-07-01

This study evaluated the efficacy of neodymium:yttrium-aluminum-garnet laser welding of flaps in canine arteries and in securing the distal flap during human carotid endarterectomy. Endarterectomy flaps were created in both common carotid and both common femoral arteries in 12 dogs. The flaps were repaired with either the neodymium:yttrium-aluminum-garnet laser or with 6-0 polypropylene sutures. The arteries were removed after duplex scanning at either 7 or 28 days. Eighteen high carotid endarterectomy flaps in 16 patients have been subsequently secured with the laser welding technique. Laser repairs (125 +/- 19 joule) of the canine arteries were completed more quickly than suture repairs (mean 25 seconds vs 135 seconds, respectively; p < 0.04). Duplex ultrasonography revealed no discernable differences between the two groups of arteries. Arteries studied at 7 days revealed three microscopic flaps (two suture, one laser), more subintimal fibroblastic proliferation in suture than laser-repaired carotid arteries (3: 1, p = 0.0530), and similar amounts of inflammation in suture- and laser-repaired arteries. Arteries studied at 28 days revealed one microscopic intimal flap (suture-repaired); equal fibroblastic and inflammatory responses in suture- and laser-repaired vessels; and no evidence of laser thermal injury. Eighteen carotid endarterectomy flaps have been successfully fused with no immediate or long-term complications in 16 patients (follow-up of 0 to 24 months). Laser fusion appears to be a safe and effective method for securing distal carotid endarterectomy flaps.

The efficacy of facial skin cancer treatment with high-energy pulsed neodymium and Nd:YAG lasers.

PubMed

Moskalik, Konstantin; Kozlov, Alexander; Demin, Eugeny; Boiko, Ernest

2009-04-01

The aim of this study was to assess the curative and cosmetic efficacy of treatment for facial skin cancer using neodymium laser irradiation. Due to the complex anatomy of the area, therapy for facial skin cancer is difficult. Laser irradiation was used for the treatment of 3461 patients with 3624 facial skin cancer lesions of stages T(1-2)N(0)M(0:) 3346 basal cell skin cancers, 188 limited basal cell skin cancer recurrences, and 90 squamous cell skin cancers. Pulsed neodymium (Nd) and Nd:YAG lasers were used as the energy sources. The patients were followed-up from 3 mo to 5 y or more. Patients with basal cell skin cancer treated by irradiation with the Nd laser developed recurrences in 1.8% of cases, and patients treated with the Nd:YAG laser had a recurrence rate of 2.5%. Recurrences following treatment for basal cell skin cancer, and those of squamous cell skin cancer, after irradiation with the Nd laser appeared in 3.7% and 4.4% of patients, respectively. Overall, the frequency of facial skin cancer recurrences after treatment with laser irradiation was 2.1% of all the irradiated tumors. Neodymium laser irradiation is an effective method to treat facial skin cancer of stages T(1-2)N(0)M(0), and results in acceptable cosmetic results.

7 CFR 457.143 - Northern potato crop insurance-quality endorsement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Northern potato crop insurance-quality endorsement. 457.143 Section 457.143 Agriculture Regulations of the Department of Agriculture (Continued) FEDERAL CROP INSURANCE CORPORATION, DEPARTMENT OF AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.143...

47 CFR 14.3 - Exemption for Customized Equipment or Services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Exemption for Customized Equipment or Services. 14.3 Section 14.3 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Scope § 14.3 Exemption for Customized Equipment...

47 CFR 14.3 - Exemption for Customized Equipment or Services.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false Exemption for Customized Equipment or Services. 14.3 Section 14.3 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Scope § 14.3 Exemption for Customized Equipment...

47 CFR 14.3 - Exemption for Customized Equipment or Services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false Exemption for Customized Equipment or Services. 14.3 Section 14.3 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Scope § 14.3 Exemption for Customized Equipment...

33 CFR 143.200 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Mobile Offshore Drilling Units § 143.200 Applicability. This subpart applies to mobile offshore drilling units when engaged in OCS activities. ...

27 CFR 53.143 - Special rules relating to further manufacture.

Code of Federal Regulations, 2010 CFR

2010-04-01

... further manufacture. 53.143 Section 53.143 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... AND AMMUNITION Exemptions, Registration, Etc. § 53.143 Special rules relating to further manufacture... the Code for use by it in further manufacture shall be treated as the manufacturer or producer of such...

45 CFR 146.143 - Preemption; State flexibility; construction.

Code of Federal Regulations, 2014 CFR

2014-10-01

....143 Section 146.143 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH INSURANCE MARKET Preemption and Special Rules § 146... to health insurance issuers. Subject to paragraph (b) of this section and except as provided in...

45 CFR 146.143 - Preemption; State flexibility; construction.

Code of Federal Regulations, 2013 CFR

2013-10-01

....143 Section 146.143 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH INSURANCE MARKET Preemption and Special Rules § 146... to health insurance issuers. Subject to paragraph (b) of this section and except as provided in...

45 CFR 146.143 - Preemption; State flexibility; construction.

Code of Federal Regulations, 2011 CFR

2011-10-01

....143 Section 146.143 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH INSURANCE MARKET Preemption and Special Rules § 146... to health insurance issuers. Subject to paragraph (b) of this section and except as provided in...

45 CFR 146.143 - Preemption; State flexibility; construction.

Code of Federal Regulations, 2012 CFR

2012-10-01

....143 Section 146.143 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS FOR THE GROUP HEALTH INSURANCE MARKET Preemption and Special Rules § 146... to health insurance issuers. Subject to paragraph (b) of this section and except as provided in...

19 CFR 143.1 - Eligibility.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.1 Eligibility. The Automated Broker Interface (ABI) is a module of the Customs Automated Commercial System (ACS) which allows participants to...

19 CFR 143.1 - Eligibility.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Automated Broker Interface § 143.1 Eligibility. The Automated Broker Interface (ABI) is a module of the Customs Automated Commercial System (ACS) which allows participants to...

13 CFR 143.52 - Collection of amounts due.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Collection of amounts due. 143.52 Section 143.52 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION UNIFORM ADMINISTRATIVE... Government. If not paid within a reasonable period after demand, the Federal agency may reduce the debt by...

40 CFR 86.143-96 - Calculations; evaporative emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... 86.143-96 Section 86.143-96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... vehicles, and for gaseous-fueled vehicles. (b) Use the measurements of initial and final concentrations to... diurnal emission testing, g. (iii) For variable-volume enclosures, defined in § 86.107(a)(1)(i), the...

22 CFR 143.39 - Alternate funds disbursal procedure.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Alternate funds disbursal procedure. 143.39 Section 143.39 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF AGE IN... recipient, any public or non-profit private organization or agency, or State or political subdivision of the...

33 CFR 143.15 - Lights and warning devices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Lights and warning devices. 143... (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT General § 143.15 Lights and warning devices. (a) OCS facilities must meet the lights and warning devices requirements under part 67 of this...

33 CFR 143.15 - Lights and warning devices.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Lights and warning devices. 143... (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT General § 143.15 Lights and warning devices. (a) OCS facilities must meet the lights and warning devices requirements under part 67 of this...

33 CFR 143.15 - Lights and warning devices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Lights and warning devices. 143... (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT General § 143.15 Lights and warning devices. (a) OCS facilities must meet the lights and warning devices requirements under part 67 of this...

33 CFR 143.15 - Lights and warning devices.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Lights and warning devices. 143... (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT General § 143.15 Lights and warning devices. (a) OCS facilities must meet the lights and warning devices requirements under part 67 of this...

33 CFR 143.15 - Lights and warning devices.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Lights and warning devices. 143... (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT General § 143.15 Lights and warning devices. (a) OCS facilities must meet the lights and warning devices requirements under part 67 of this...

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

29 CFR 14.3 - DOL Classification Review Committee.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 1 2014-07-01 2013-07-01 true DOL Classification Review Committee. 14.3 Section 14.3 Labor... Classification Review Committee. A DOL Classification Review Committee is hereby established. (a) Composition of... under the Freedom of Information Act, 5 U.S.C. 552, when a proposed denial is based on classification...

Neodymium doped hydroxyapatite theranostic nanoplatforms for colon specific drug delivery applications.

PubMed

Victor, Sunita Prem; Paul, Willi; Vineeth, V M; Komeri, Remya; Jayabalan, Muthu; Sharma, Chandra P

2016-09-01

Theranostic nanoplatforms integrate therapeutic payloads with diagnostic agents, and help monitor therapeutic response. In this regard, stimuli responsive nanoplatforms further favour combinatorial therapeutic approach that can considerably improve efficacy and specificity of treatment. Herein, we present the engineering of a smart theranostic nanoplatform based on neodymium doped hydroxyapatite (HAN). The presence of neodymium endows the HAN nanoplatforms with near-infrared fluorescence capability. These HAN nanoparticles were then subsequently modified with alginic acid (HANA) to confer pH responsiveness to the synthesized nanoplatforms delivering them to the colon after oral administration. These nanoplatforms possessing optimum size, needle shaped morphology and negative zeta potential, are conducive to cellular internalization. On excitation at 410nm they exhibit near infrared emission at 670nm unraveling their theranostic capabilities. Cytotoxic effects systematically assessed using MTT and live dead assays reveal excellent viability. Raman microscopic imaging technique used to visualize uptake in HeLa cells demonstrate increased uptake from 4 to 16h, with growing cluster size and localization in the cytoplasm. Moreover the concomitant presence of alginic acid manifested advantages of augmented loading and pH dependent release profiles of the model drug, 4 acetyl salicylic acid (4ASA). We could thus establish a theranostic system for early tumour detection, targeted tumour therapy and monitoring of colon cancer that can be administered via the oral route. Copyright © 2016 Elsevier B.V. All rights reserved.

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true What is a small high school? 39.143 Section 39.143 Indians... Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is staffed with...

Neodymium isotopes in biogenic carbonates: reliable archives of ɛNd

NASA Astrophysics Data System (ADS)

Montagna, P.; Goldstein, S. L.; Taviani, M.; Frank, N.; McCulloch, M. T.

2010-12-01

Neodymium isotope (143Nd/144Nd) compositions from dispersed authigenic ferromanganese oxide fraction in marine sediments, ferromanganese crusts, foraminiferal shells and fossil fish teeth are employed to trace provenance and water mass mixing in the past, having the advantage of not being fractionated by biological processes in the water column. In the modern ocean the different water masses ultimately derive their ɛNd values through continental weathering, erosion and particle-seawater interactions. This geochemical tracer has been only recently applied to scleractinian deep-water coral skeletons sourced from various sites and depths in the Atlantic ocean. Aragonitic corals can be precisely dated by U-series, potentially providing century-long records of intermediate and bathyal zone variability at sub-decadal resolution. Motivated by these recent findings we have investigated the Nd isotopic compositions of living specimens of various calcifying organisms collected in two key locations of the Mediterranean Sea and in the Southern Ocean. In particular, we analyzed several specimens of the aragonitic deep-water corals Desmophyllum dianthus, Lophelia pertusa, Madrepora oculata, Flabellum impensum, the temperate coral Cladocora caespitosa, the calcitic gorgonian coral Corallium rubrum, the bivalves Glans aculeata and Karnekampia bruei and the polychate Serpula vermicularis. Most of the samples were retrieved from the Strait of Sicily and the Southern Adriatic Sea at different water depths. Ten seawater samples from three new profiles in the Mediterranean were also collected at the same locations and depths, offering a unique opportunity to compare the Nd isotopic composition of biogenic carbonates directly with the surrounding ambient seawater. The Mediterranean Sea is particularly suited for this comparison exercise since it is characterized by water masses displaying a large range of ɛNd values, from -10.5 in the Western Mediterranean to -4.8 in the Eastern

The Inhibitor Ko143 Is Not Specific for ABCG2.

PubMed

Weidner, Lora D; Zoghbi, Sami S; Lu, Shuiyu; Shukla, Suneet; Ambudkar, Suresh V; Pike, Victor W; Mulder, Jan; Gottesman, Michael M; Innis, Robert B; Hall, Matthew D

2015-09-01

Imaging ATP-binding cassette (ABC) transporter activity in vivo with positron emission tomography requires both a substrate and a transporter inhibitor. However, for ABCG2, there is no inhibitor proven to be specific to that transporter alone at the blood-brain barrier. Ko143 [[(3S,6S,12aS)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4- b]indole-3-propanoic acid 1,1-dimethylethyl ester], a nontoxic analog of fungal toxin fumitremorgin C, is a potent inhibitor of ABCG2, although its specificity in mouse and human systems is unclear. This study examined the selectivity of Ko143 using human embryonic kidney cell lines transfected with ABCG2, ABCB1, or ABCC1 in several in vitro assays. The stability of Ko143 in rat plasma was measured using high performance liquid chromatography. Our results show that, in addition to being a potent inhibitor of ABCG2, at higher concentrations (≥1 μM) Ko143 also has an effect on the transport activity of both ABCB1 and ABCC1. Furthermore, Ko143 was found to be unstable in rat plasma. These findings indicate that Ko143 lacks specificity for ABCG2 and this should be taken into consideration when using Ko143 for both in vitro and in vivo experiments. U.S. Government work not protected by U.S. copyright.

29 CFR 1910.143 - Nonwater carriage disposal systems. [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 5 2010-07-01 2010-07-01 false Nonwater carriage disposal systems. [Reserved] 1910.143 Section 1910.143 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS General Environmental Controls...

42 CFR 410.143 - Requirements for approved accreditation organizations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 2 2011-10-01 2011-10-01 false Requirements for approved accreditation organizations. 410.143 Section 410.143 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Outpatient...

42 CFR 410.143 - Requirements for approved accreditation organizations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 2 2012-10-01 2012-10-01 false Requirements for approved accreditation organizations. 410.143 Section 410.143 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Outpatient...

7 CFR 1260.143 - Nominations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Cattlemen's Beef Promotion and Research Board § 1260.143 Nominations. All...

MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression

PubMed Central

Osaki, Mitsuhiko; Takeshita, Fumitaka; Sugimoto, Yui; Kosaka, Nobuyoshi; Yamamoto, Yusuke; Yoshioka, Yusuke; Kobayashi, Eisuke; Yamada, Tesshi; Kawai, Akira; Inoue, Toshiaki; Ito, Hisao; Oshimura, Mitsuo; Ochiya, Takahiro

2011-01-01

Pulmonary metastases are the main cause of death in patients with osteosarcoma, however, the molecular mechanisms of metastasis are not well understood. To detect lung metastasis-related microRNA (miRNA) in human osteosarcoma, we compared parental (HOS) and its subclone (143B) human osteosarcoma cell lines showing lung metastasis in a mouse model. miR-143 was the most downregulated miRNA (P < 0.01), and transfection of miR-143 into 143B significantly decreased its invasiveness, but not cell proliferation. Noninvasive optical imaging technologies revealed that intravenous injection of miR-143, but not negative control miRNA, significantly suppressed lung metastasis of 143B (P < 0.01). To search for miR-143 target mRNA in 143B, microarray analyses were performed using an independent RNA pool extracted by two different comprehensive miR-143-target mRNA collecting systems. Western blot analyses revealed that MMP-13 was mostly protein downregulated by miR-143. Immunohistochemistry using clinical samples clearly revealed MMP-13-positive cells in lung metastasis-positive cases, but not in at least three cases showing higher miR-143 expression in the no metastasis group. Taken together, these data indicated that the downregulation of miR-143 correlates with the lung metastasis of human osteosarcoma cells by promoting cellular invasion, probably via MMP-13 upregulation, suggesting that miRNA could be used to develop new molecular targets for osteosarcoma metastasis. PMID:21427707

42 CFR 410.143 - Requirements for approved accreditation organizations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 2 2014-10-01 2014-10-01 false Requirements for approved accreditation organizations. 410.143 Section 410.143 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... decisions and any accreditation-related information that CMS may require (including corrective action plans...

19 CFR 143.35 - Procedure for electronic entry summary.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Procedure for electronic entry summary. 143.35...; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Electronic Entry Filing § 143.35 Procedure for electronic entry summary. In order to obtain entry summary processing electronically, the filer...

19 CFR 143.35 - Procedure for electronic entry summary.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Procedure for electronic entry summary. 143.35...; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Electronic Entry Filing § 143.35 Procedure for electronic entry summary. In order to obtain entry summary processing electronically, the filer...

19 CFR 143.35 - Procedure for electronic entry summary.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 2 2012-04-01 2012-04-01 false Procedure for electronic entry summary. 143.35...; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Electronic Entry Filing § 143.35 Procedure for electronic entry summary. In order to obtain entry summary processing electronically, the filer...

30 CFR 14.3 - Observers at tests and evaluations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Observers at tests and evaluations. 14.3 Section 14.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS REQUIREMENTS FOR THE APPROVAL OF FLAME-RESISTANT CONVEYOR BELTS...

19 CFR 143.32 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Electronic Entry Filing § 143.32 Definitions. The following are... broker licensed under part 111 of this chapter. (e) Certification. “Certification” means the electronic equivalent of a signature for data transmitted through ABI. This electronic (facsimile) signature must be...

7 CFR 4279.143 - Insurance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... be in amounts necessary to provide for management succession or to protect the business. The cost of... Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GUARANTEED LOANMAKING Business and Industry Loans § 4279.143...

40 CFR 63.143 - Process wastewater provisions-inspections and monitoring of operations.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-inspections and monitoring of operations. 63.143 Section 63.143 Protection of Environment ENVIRONMENTAL..., and Wastewater § 63.143 Process wastewater provisions—inspections and monitoring of operations. (a) For each wastewater tank, surface impoundment, container, individual drain system, and oil-water...

40 CFR 63.143 - Process wastewater provisions-inspections and monitoring of operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-inspections and monitoring of operations. 63.143 Section 63.143 Protection of Environment ENVIRONMENTAL..., and Wastewater § 63.143 Process wastewater provisions—inspections and monitoring of operations. (a) For each wastewater tank, surface impoundment, container, individual drain system, and oil-water...

40 CFR 63.143 - Process wastewater provisions-inspections and monitoring of operations.

Code of Federal Regulations, 2011 CFR

2011-07-01

...-inspections and monitoring of operations. 63.143 Section 63.143 Protection of Environment ENVIRONMENTAL..., and Wastewater § 63.143 Process wastewater provisions—inspections and monitoring of operations. (a) For each wastewater tank, surface impoundment, container, individual drain system, and oil-water...

40 CFR 63.143 - Process wastewater provisions-inspections and monitoring of operations.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-inspections and monitoring of operations. 63.143 Section 63.143 Protection of Environment ENVIRONMENTAL..., and Wastewater § 63.143 Process wastewater provisions—inspections and monitoring of operations. (a) For each wastewater tank, surface impoundment, container, individual drain system, and oil-water...

Electrochemical extraction of neodymium by co-reduction with aluminum in LiCl-KCl molten salt

NASA Astrophysics Data System (ADS)

Yan, Yong-De; Xu, Yan-Lu; Zhang, Mi-Lin; Xue, Yun; Han, Wei; Huang, Ying; Chen, Qiong; Zhang, Zhi-Jian

2013-02-01

The electrochemical behavior of Nd(III) ions in LiCl-KCl and LiCl-KCl-AlCl3 melts on a Mo electrode at 723 K was studied by various electrochemical techniques. The results showed that Nd(III) ions are reduced to Nd(0) through two consecutive steps, and the underpotential deposition of neodymium on pre-deposited Al electrode formed two kinds of Al-Nd intermetallic compounds in LiCl-KCl-AlCl3 solutions. The electrochemical extraction of neodymium was carried out in LiCl-KCl-AlCl3 melts on a Mo electrode at 873 K by potentiostatic and galvanostatic electrolysis. The extraction efficiency was 99.25% after potentiostatic electrolysis for 30 h. Al-Li-Nd bulk alloy was obtained by galvanostatic electrolysis. X-ray diffraction (XRD) suggested that Al2Nd and Al3Nd phases were formed in Al-Li-Nd alloy. The microstructure and micro-zone chemical analysis of Al-Li-Nd alloy were characterized by scanning electron microscopy (SEM) with energy dispersive spectrometry (EDS), respectively.

Twenty-Eight-Day Repeated Inhalation Toxicity Study of Nano-Sized Neodymium Oxide in Male Sprague-Dawley Rats

PubMed Central

Kim, Yong-Soon; Lim, Cheol-Hong; Shin, Seo-Ho; Kim, Jong-Choon

2017-01-01

Neodymium is a future-oriented material due to its unique properties, and its use is increasing in various industrial fields worldwide. However, the toxicity caused by repeated exposure to this metal has not been studied in detail thus far. The present study was carried out to investigate the potential inhalation toxicity of nano-sized neodymium oxide (Nd2O3) following a 28-day repeated inhalation exposure in male Sprague-Dawley rats. Male rats were exposed to nano-sized Nd2O3-containing aerosols via a nose-only inhalation system at doses of 0 mg/m3, 0.5 mg/m3, 2.5 mg/m3, and 10 mg/m3 for 6 hr/day, 5 days/week over a 28-day period, followed by a 28-day recovery period. During the experimental period, clinical signs, body weight, hematologic parameters, serum biochemical parameters, necropsy findings, organ weight, and histopathological findings were examined; neodymium distribution in the major organs and blood, bronchoalveolar lavage fluid (BALF), and oxidative stress in lung tissues were analyzed. Most of the neodymium was found to be deposited in lung tissues, showing a dose-dependent relationship. Infiltration of inflammatory cells and pulmonary alveolar proteinosis (PAP) were the main observations of lung histopathology. Infiltration of inflammatory cells was observed in the 2.5 mg/m3 and higher dose treatment groups. PAP was observed in all treatment groups accompanied by an increase in lung weight, but was observed to a lesser extent in the 0.5 mg/m3 treatment group. In BALF analysis, total cell counts, including macrophages and neutrophils, lactate dehydrogenase, albumin, interleukin-6, and tumor necrosis factor-alpha, increased significantly in all treatment groups. After a 4-week recovery period, these changes were generally reversed in the 0.5 mg/m3 group, but were exacerbated in the 10 mg/m3 group. The lowest-observed-adverse-effect concentration of nano-sized Nd2O3 was determined to be 0.5 mg/m3, and the target organ was determined to be the lung

40 CFR 143.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL SECONDARY DRINKING WATER REGULATIONS § 143.1 Purpose. This part establishes National Secondary Drinking Water Regulations pursuant to section 1412 of the Safe Drinking Water Act, as amended (42 U.S.C. 300g-1...

[The first experience with the concurrent effect of YAG-neodymium and YAG-erbium laser on experimental animal tissues and the possibility of its use in surgery].

PubMed

Roshal', L M; Gorbatova, N E; Livshits, Iu L; Parkhomenko, Iu G; Osiko, V V; Danileĭko, Iu K; Sidorin, A V; Tylaĭkova, T B; Ivanov, A D

1991-08-01

To guarantee the necessary rate of cutting live tissues with adequate hemostasis along the line of the incision, the authors studied isolated and joint effect of radiations of AIG-neodymium and AIG-erbium lasers on the tissues of laboratory animals. The possibility of accomplishing intraoperative hemostasis on the parenchymal organs was studied in experiments with AIG-neodymium laser. A good dissection effect in cutting various tissues was produced in the second series of experiments with AIG-erbium laser. The simultaneous action of AIG-neodymium and AIG-erbium beams converged at one point on the surface of the biological object was studied in the third series of experiments. It was found that the effect ensures a good dissection of tissues with sufficient hemostasis. The results of dynamic morphological studies are shown. The possibility of using the device in surgery is discussed.

40 CFR 35.143 - Allotment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.143 Allotment. (a) The Administrator allots air pollution control funds under section 105 of the Clean Air Act based on a number of...

40 CFR 35.143 - Allotment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.143 Allotment. (a) The Administrator allots air pollution control funds under section 105 of the Clean Air Act based on a number of...

40 CFR 35.143 - Allotment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.143 Allotment. (a) The Administrator allots air pollution control funds under section 105 of the Clean Air Act based on a number of...

Neodymium oxide: A new thermoluminescent material for gamma dosimetry

NASA Astrophysics Data System (ADS)

Soliman, C.

2006-10-01

In the present study thermoluminescence (TL) glow curves of commercial and gamma (0.001 Gy to 100 kGy) exposed neodymium oxide (Nd 2O 3) have been investigated. The commercial glow curve is simple with TL peaks at 310, 350 and 385 °C. The TL sensitivity was enhanced to ˜4.7 times the original value when the investigated material was subject to pre-heating treatment at 800 °C for 1 h. The effect of storage time at room temperature has been monitored for different γ-doses. The combination of good γ-dose response and high stability of defects offer the possibility of applying the investigated material to γ-ray dosimetry in radiotherapy and experimental radiology range.

14 CFR 382.143 - When must carriers complete training for their personnel?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false When must carriers complete training for their personnel? 382.143 Section 382.143 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.143 When must carriers complete training for their...

14 CFR 382.143 - When must carriers complete training for their personnel?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false When must carriers complete training for their personnel? 382.143 Section 382.143 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.143 When must carriers complete training for their...

14 CFR 382.143 - When must carriers complete training for their personnel?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false When must carriers complete training for their personnel? 382.143 Section 382.143 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.143 When must carriers complete training for their...

14 CFR 382.143 - When must carriers complete training for their personnel?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false When must carriers complete training for their personnel? 382.143 Section 382.143 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.143 When must carriers complete training for their...

14 CFR 382.143 - When must carriers complete training for their personnel?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false When must carriers complete training for their personnel? 382.143 Section 382.143 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.143 When must carriers complete training for their...

40 CFR 35.143 - Allotment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.143 Allotment. (a) The Administrator allots air pollution control funds under section 105 of the Clean Air Act based on a number of factors, including: (1) Population; (2) The extent of actual or potential air pollution problems; and (3...

40 CFR 35.143 - Allotment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.143 Allotment. (a) The Administrator allots air pollution control funds under section 105 of the Clean Air Act based on a number of factors, including: (1) Population; (2) The extent of actual or potential air pollution problems; and (3...

19 CFR 143.42 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Remote Location Filing § 143.42 Definitions. The following definitions... E: (a) Remote Location Filing (RLF)—“RLF” is an elective method of making entry by which a customs... from a remote location other than where the goods are being entered. (Importers filing on their own...

19 CFR 143.42 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Remote Location Filing § 143.42 Definitions. The following definitions... E: (a) Remote Location Filing (RLF)—“RLF” is an elective method of making entry by which a customs... from a remote location other than where the goods are being entered. (Importers filing on their own...

19 CFR 143.42 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Remote Location Filing § 143.42 Definitions. The following definitions... E: (a) Remote Location Filing (RLF)—“RLF” is an elective method of making entry by which a customs... from a remote location other than where the goods are being entered. (Importers filing on their own...

19 CFR 143.42 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Remote Location Filing § 143.42 Definitions. The following definitions... E: (a) Remote Location Filing (RLF)—“RLF” is an elective method of making entry by which a customs... from a remote location other than where the goods are being entered. (Importers filing on their own...

19 CFR 143.42 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Remote Location Filing § 143.42 Definitions. The following definitions... E: (a) Remote Location Filing (RLF)—“RLF” is an elective method of making entry by which a customs... from a remote location other than where the goods are being entered. (Importers filing on their own...

MicroRNA-143 suppresses gastric cancer cell growth and induces apoptosis by targeting COX-2

PubMed Central

Wu, Xiao-Li; Cheng, Bin; Li, Pei-Yuan; Huang, Huan-Jun; Zhao, Qiu; Dan, Zi-Li; Tian, De-An; Zhang, Peng

2013-01-01

AIM: To investigate the function of microRNA-143 (miR-143) in gastric cancer and explore the target genes of miR-143. METHODS: A quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis was performed to evaluate miR-143 expression in gastric cancer cell lines. After transfecting gastric cancer cells with miR-143-5p and miR-143-3p precursors, Alamar blue and apoptosis assays were used to measure the respective proliferation and apoptosis rates. Cyclooxygenase-2 (COX-2) expression was determined by real-time RT-PCR and Western blot assays after miR-143 transfection. Reporter plasmids were constructed, and a luciferase reporter assay was used to identify the miR-143 binding site on COX-2. RESULTS: Both miR-143-5p and miR-143-3p were significantly downregulated in multiple gastric cancer cell lines. Forced miR-143-5p and miR-143-3p expression in gastric cancer cells produced a profound cytotoxic effect. MiR-145-5p transfection into gastric cancer cells resulted in a greater growth inhibitory effect (61.23% ± 3.16% vs 46.58% ± 4.28%, P < 0.05 in the MKN-1 cell line) and a higher apoptosis rate (28.74% ± 1.93% vs 22.13% ± 3.31%, P < 0.05 in the MKN-1 cell line) than miR-143-3p transfection. Further analysis indicated that COX-2 expression was potently suppressed by miR-143-5p but not by miR-143-3p. The activity of a luciferase reporter construct that contained the 3’-untranslated region (UTR) of COX-2 was downregulated by miR-143-5p (43.6% ± 4.86%, P < 0.01) but not by miR-143-3p. A mutation in the miR-145-5p binding site completely ablated the regulatory effect on luciferase activity, which suggests that there is a direct miR-145-5p binding site in the 3’-UTR of COX-2. CONCLUSION: Both miR-143-5p and miR-143-3p function as anti-oncomirs in gastric cancer. However, miR-143-5p alone directly targets COX-2, and it exhibits a stronger tumor suppressive effect than miR-143-3p. PMID:24616567

Neodymium cobalt oxide as a chemical sensor

NASA Astrophysics Data System (ADS)

Abdel-Latif, I. A.; Rahman, Mohammed M.; Khan, Sher Bahadar

2018-03-01

Chemical sensing and electrical transport properties of neodymium coblate, NdCoO3, was investigated in this work. It was prepared by using co-precipitation method. Pure neodymium chloride and cobalt chloride were mixing in the presence of sodium hydroxide and the obtained co-precipitated powder was calcined at 850 and 1000 °C. The synthesized composites, as-grown (NdCoO3-I), calcined at 850 °C (NdCoO3-II), and calcined at 1000 °C (NdCoO3-III) were studied in details in terms of their morphological and structural properties. The X-ray analysis confirmed that the synthesized products are well crystalline possessing single phase orthorhombic crystal system of space group Pbnm(62). The crystallite size of NdCoO3-I, NdCoO3-II, and NdCoO3-III is 22, 111, and 338 nm, respectively which reflect that crystallite size is increasing with increase in firing temperature. The DC resistivity was measured as a function of temperature in the temperature range from room temperature up to 200 °C. All NdCoO3 are semiconductor in this range of temperature but showed different activation energy which strongly depends on the crystallite size of the products. The activation energy decreased with increase in crystallite size, 0.798, 0.414 and 0.371 eV for NdCoO3-I, NdCoO3-II, and NdCoO3-III, respectively. Thus resistivity increases with increase in crystallite size of NdCoO3. All NdCoO3 products were tested as chemical sensor for acetone by electrochemical approaches and showed excellent sensitivity. Among the NdCoO3 samples, NdCoO3-III showed the highest sensitivity (3.4722 μAcm-2 mM-1) compared to other compositions and gradually decreased to 3.2407 μAcm-2 mM-1 with decreasing the crystallite size of NdCoO3-II. It is also observed that the sensitivity drastically decreased to 0.76253 μAcm-2 mM-1 in the case of NdCoO3-I. It is introduced an efficient route for the detection of environmental unsafe chemicals by electrochemical approach for the safety of healthcare and environmental

LASERS: Ultimate energy parameters of the radiation emitted from neodymium-glass laser systems

NASA Astrophysics Data System (ADS)

Eshmemet'eva, E. V.; Korolev, V. I.; Mesnyankin, E. P.; Serebryakov, V. A.; Shashkin, V. V.; Yashin, V. E.

1992-09-01

An experimental investigation was made of the energy conversion efficiency and of the effects of stimulated Brillouin scattering and of optical breakdown, limiting the maximum energy density obtained from several phosphate and silicate neodymium glasses when the duration of the output pulses was 50-150 ns. The experimental results were used to develop a numerical model for calculation of the gain allowing for these processes. A design was developed for an amplifier with ultimate radiation characteristics.

27 CFR 44.143 - General.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Operations by Export Warehouse Proprietors Inventories § 44.143... and accurate inventory of products held on TTB Form 5220.3 (3373). (b) This inventory shall be subject to verification by an appropriate TTB officer. A copy of each inventory shall be retained by the...

13 CFR 143.42 - Retention and access requirements for records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Retention and access requirements for records. 143.42 Section 143.42 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... period. (1) Except as otherwise provided, records must be retained for three years from the starting date...

42 CFR 456.143 - Content of medical care evaluation studies.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Content of medical care evaluation studies. 456.143...: Medical Care Evaluation Studies § 456.143 Content of medical care evaluation studies. Each medical care evaluation study must— (a) Identify and analyze medical or administrative factors related to the hospital's...

Watt-level single-frequency tunable neodymium MOPA fiber laser operating at 915-937 nm

NASA Astrophysics Data System (ADS)

Rota-Rodrigo, S.; Gouhier, B.; Laroche, M.; Zhao, J.; Canuel, B.; Bertoldi, A.; Bouyer, P.; Traynor, N.; Cadier, B.; Robin, T.; Santarelli, G.

2018-02-01

We have developed a Watt-level single-frequency tunable fiber laser in the 915-937 nm spectral window. The laser is based on a neodymium-doped fiber master oscillator power amplifier architecture, with two amplification stages using a 20 mW extended cavity diode laser as seed. The system output power is higher than 2 W from 921 to 933 nm, with a stability better than 1.4% and a low relative intensity noise.

UV and fluorescence spectral changes induced by neodymium binding of N,N'-ethylenebis[2-(o-hydroxyphenolic)glycine] and N,N'-di(2-hydroxybenzyl)ethylenediamine-N,N' diacetic acid.

PubMed

Wang, Zhijun; Yang, Binsheng

2006-11-01

In 0.01 M 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (Hepes), pH 7.4 and room temperature, the binding of neodymium to N,N'-ethylenebis[2-(o-hydroxyphenolic)glycine] (EHPG), or N,N'-di(2-hydroxybenzyl)ethylenediamine-N,N' diacetic acid (HBED) had been studied from 210 to 330 nm by means of difference UV spectra. Two peaks at 240 and 292 nm appear in difference UV spectra after neodymium binding to EHPG or HBED. The 1:1 stable complex can be confirmed from spectral titration curves. The molar extinction coefficient of Nd-EHPG and Nd-HBED complexes are Deltaepsilon(Nd-EHPG)=(12.93+/-0.21) x 10(3)cm(-1)M(-1), Deltaepsilon(Nd-HBED)=(14.45+/-0.51) x 10(5)cm(-1)M(-1) at 240 nm, respectively. Using EDTA as a competitor, the conditional equilibrium constants of the complexes are logK(Nd-EHPG)=11.89+/-0.09 and logK(Nd-HBED)=12.19+/-0.15, respectively. At the same conditions, fluorescence measurements show that neodymium binding to EHPG leads to a quenching of the fluorescence of EHPG at near 310 nm. However, there is no obvious fluorescence change of HBED at 318 nm with the binding of neodymium to HBED.

42 CFR 456.143 - Content of medical care evaluation studies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Content of medical care evaluation studies. 456.143...: Medical Care Evaluation Studies § 456.143 Content of medical care evaluation studies. Each medical care... patient care; (b) Include analysis of at least the following: (1) Admissions; (2) Durations of stay; (3...

40 CFR 81.143 - Central Virginia Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Central Virginia Intrastate Air Quality Control Region. 81.143 Section 81.143 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., Lynchburg, Martinsville, South Boston. Towns—Blackstone, Farmville, Rocky Mount, South Hill. ...

The transcriptional activator ZNF143 is essential for normal development in zebrafish

PubMed Central

2012-01-01

Background ZNF143 is a sequence-specific DNA-binding protein that stimulates transcription of both small RNA genes by RNA polymerase II or III, or protein-coding genes by RNA polymerase II, using separable activating domains. We describe phenotypic effects following knockdown of this protein in developing Danio rerio (zebrafish) embryos by injection of morpholino antisense oligonucleotides that target znf143 mRNA. Results The loss of function phenotype is pleiotropic and includes a broad array of abnormalities including defects in heart, blood, ear and midbrain hindbrain boundary. Defects are rescued by coinjection of synthetic mRNA encoding full-length ZNF143 protein, but not by protein lacking the amino-terminal activation domains. Accordingly, expression of several marker genes is affected following knockdown, including GATA-binding protein 1 (gata1), cardiac myosin light chain 2 (cmlc2) and paired box gene 2a (pax2a). The zebrafish pax2a gene proximal promoter contains two binding sites for ZNF143, and reporter gene transcription driven by this promoter in transfected cells is activated by this protein. Conclusions Normal development of zebrafish embryos requires ZNF143. Furthermore, the pax2a gene is probably one example of many protein-coding gene targets of ZNF143 during zebrafish development. PMID:22268977

The transcriptional activator ZNF143 is essential for normal development in zebrafish.

PubMed

Halbig, Kari M; Lekven, Arne C; Kunkel, Gary R

2012-01-23

ZNF143 is a sequence-specific DNA-binding protein that stimulates transcription of both small RNA genes by RNA polymerase II or III, or protein-coding genes by RNA polymerase II, using separable activating domains. We describe phenotypic effects following knockdown of this protein in developing Danio rerio (zebrafish) embryos by injection of morpholino antisense oligonucleotides that target znf143 mRNA. The loss of function phenotype is pleiotropic and includes a broad array of abnormalities including defects in heart, blood, ear and midbrain hindbrain boundary. Defects are rescued by coinjection of synthetic mRNA encoding full-length ZNF143 protein, but not by protein lacking the amino-terminal activation domains. Accordingly, expression of several marker genes is affected following knockdown, including GATA-binding protein 1 (gata1), cardiac myosin light chain 2 (cmlc2) and paired box gene 2a (pax2a). The zebrafish pax2a gene proximal promoter contains two binding sites for ZNF143, and reporter gene transcription driven by this promoter in transfected cells is activated by this protein. Normal development of zebrafish embryos requires ZNF143. Furthermore, the pax2a gene is probably one example of many protein-coding gene targets of ZNF143 during zebrafish development.

Neodymium-doped phosphate fiber lasers with an all-solid microstructured inner cladding.

PubMed

Zhang, Guang; Zhou, Qinling; Yu, Chunlei; Hu, Lili; Chen, Danping

2012-06-15

We report on high-power fiber lasers based on index-guiding, all-solid neodymium-doped (Nd-doped) phosphate photonic crystal fiber (PCF) with a hexagonal-shaped inner cladding. The optimum fiber laser with a 36 cm length active fiber, generated up to 7.92 W output power at 1053 nm, which benefited from a high absorption coefficient for pump power due to its noncircular inner cladding. The guiding properties of the all-solid PCF were also investigated. A stable mode with a donut-shaped profile and a power-dependent laser beam quality have been observed experimentally and analyzed.

Neodymium Isotope Variations in Late Quaternary Carbonate Lake Sediments, Owens Valley, Eastern California.

NASA Astrophysics Data System (ADS)

Minervini, J. M.; Stewart, B. W.

2001-12-01

Owens Lake is situated in a mostly-closed basin fed by water and sediments derived primarily from the eastern Sierra Nevada range. Chemical and sedimentological variations in USGS Owens Lake Core OL-92, which extends back 800 ka, have been shown to be sensitive tracers of Great Basin paleoclimate. Here we report preliminary neodymium (Nd) isotope data from core OL-92 to investigate sediment provenance, the chemical behavior of rare earth elements (REE) in non-marine systems, and possible climate-related shifts in weathering patterns of the eastern Sierra Nevada during the last glacial-interglacial transition. Neodymium isotopic analyses were carried out on the carbonate fraction of sediment samples ranging in age from 16.8 to 6.9 ka from Owens Lake core OL-92. Samples were treated with ammonium acetate to remove exchangeable cations from coexisting silicate material, and subsequently leached with 8% acetic acid to dissolve carbonate minerals. Based on the mass of sediment leached with acetic acid, the fraction of carbonate (relative to clastic silicate material) increases from 6.6 to 66.5% over the 10 ka period represented by these samples. This increase in carbonate reflects desiccation of the Owens Lake basin; as streamwater flow is reduced, the lake spends a greater proportion of its time saturated in carbonate minerals, and clastic input might also be reduced. Concentrations of Nd in Owens Lake carbonate range from 7 to 170 ppm, values that are 2-1000 times higher than marine planktonic foraminifera (e.g., Vance and Burton, 1999, EPSL 173, 365). In general, high concentrations of Nd in Owens Lake carbonate are associated with older sediment samples with lower carbonate fractions. The decrease in Nd concentration over this time period could be a result of extraction of Nd from lake waters by precipitation of carbonate as desiccation proceeded. Epsilon-Nd values of Owens Lake carbonate range from -5.3 to -6.5, and are consistent with eastern Sierra Nevada

19 CFR 191.143 - Drawback entry.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.143 Drawback entry. (a) Filing of entry. Drawback entries covering these foreign-built jet aircraft engines shall be filed on Customs Form 7551, modified to show that the entry covers jet aircraft engines processed under...

19 CFR 191.143 - Drawback entry.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.143 Drawback entry. (a) Filing of entry. Drawback entries covering these foreign-built jet aircraft engines shall be filed on Customs Form 7551, modified to show that the entry covers jet aircraft engines processed under...

17 CFR 143.7 - Delegation of authority to the Executive Director.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Delegation of authority to the Executive Director. 143.7 Section 143.7 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION COLLECTION OF CLAIMS OWED THE UNITED STATES ARISING FROM ACTIVITIES UNDER THE COMMISSION'S...

MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice.

PubMed

Sala, Federica; Aranda, Juan F; Rotllan, Noemi; Ramírez, Cristina M; Aryal, Binod; Elia, Leonardo; Condorelli, Gianluigi; Catapano, Alberico Luigi; Fernández-Hernando, Carlos; Norata, Giuseppe Danilo

2014-10-01

The miR-143/145 cluster regulates VSMC specific gene expression, thus controlling differentiation, plasticity and contractile function, and promoting the VSMC phenotypic switch from a contractile/non-proliferative to a migrating/proliferative state. More recently increased miR-145 expression was observed in human carotid atherosclerotic plaques from symptomatic patients. The goal of this study was to investigate the contribution of miR-143/145 during atherogenesis by generating mice lacking miR-143/145 on an Ldlr-deficient background. Ldlr-/- and Ldlr-/--miR-143/145-/- (DKO) were fed a Western diet (WD) for 16 weeks. At the end of the treatment, the lipid profile and the atherosclerotic lesions were assessed in both groups of mice. Absence of miR-143/145 significantly reduced atherosclerotic plaque size and macrophage infiltration. Plasma total cholesterol levels were lower in DKO and FLPC analysis showed decreased cholesterol content in VLDL and LDL fractions. Interestingly miR-143/145 deficiency per se resulted in increased hepatic and vascular ABCA1 expression. We further confirmed the direct regulation of miR-145 on ABCA1 expression by qRT-PCR, Western blotting and 3'UTR-luciferase reporter assays. In summary, miR-143/145 deficiency significantly reduces atherosclerosis in mice. Therapeutic inhibition of miR-145 might be useful for treating atherosclerotic vascular disease.

13 CFR 143.22 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... to that circular 48 CFR part 31. Contract Cost Principles and Procedures, or uniform cost accounting... Financial Administration § 143.22 Allowable costs. (a) Limitation on use of funds. Grant funds may be used... grantee or subgrantee. (b) Applicable cost principles. For each kind of organization, there is a set of...

Solid-state reaction kinetics of neodymium doped magnesium hydrogen phosphate system

NASA Astrophysics Data System (ADS)

Gupta, Rashmi; Slathia, Goldy; Bamzai, K. K.

2018-05-01

Neodymium doped magnesium hydrogen phosphate (NdMHP) crystals were grown by using gel encapsulation technique. Structural characterization of the grown crystals has been carried out by single crystal X-ray diffraction (XRD) and it revealed that NdMHP crystals crystallize in orthorhombic crystal system with space group Pbca. Kinetics of the decomposition of the grown crystals has been studied by non-isothermal analysis. The estimation of decomposition temperatures and weight loss has been made from the thermogravimetric/differential thermo analytical (TG/DTA) in conjuncture with DSC studies. The various steps involved in the thermal decomposition of the material have been analysed using Horowitz-Metzger, Coats-Redfern and Piloyan-Novikova equations for evaluating various kinetic parameters.

Nuclear Data Sheets for A = 143

NASA Astrophysics Data System (ADS)

Browne, E.; Tuli, J. K.

2012-03-01

The evaluators present in this publication spectroscopic data and level schemes from radioactive decay and nuclear reaction studies for all nuclei with mass number A = 143. The evaluation, which includes all data received by May 2011, supersedes the 2001 evaluation by J.K. Tuli, published in Nuclear Data Sheets94, 605 (2001).

Nuclear Data Sheets for A=143

DOE Office of Scientific and Technical Information (OSTI.GOV)

Browne E.; Tuli J.; Browne,E.

The evaluators present in this publication spectroscopic data and level schemes from radioactive decay and nuclear reaction studies for all nuclei with mass number A = 143. The evaluation, which includes all data received by May 2011, supersedes the 2001 evaluation by J.K. Tuli, published in Nuclear Data Sheets94, 605 (2001).

Femtosecond diode-pumped mode-locked neodymium lasers

NASA Astrophysics Data System (ADS)

Kubeček, Václav; Jelínek, Michal; Čech, Miroslav; Vyhlídal, David; Su, Liangbi; Jiang, Dapeng; Ma, Fengkai; Qian, Xiaobo; Wang, Jingya; Xu, Jun

2016-12-01

Fluoride-type crystals (CaF2, SrF2) doped with neodymium Nd3+ and codoped with buffer ions for breaking clusters of active ions and increasing fluorescence efficiency, present interesting alternative as laser active media for the diode-pumped mode-locked lasers. In comparison with widely used materials as Nd:YAG or Nd:YVO4, they have broad emission spectra as well as longer fluorescence lifetime, in comparison with Nd:glass, SrF2 and CaF2 have better thermal conductivity. In spite of the fact, that this thermal conductivity decreases with Nd3+ doping concentration, these crystals are alternative for the Nd:glass in subpicosecond mode-locked laser systems. In this paper we review the basic results reported recently on these active materials and in the second part we present our results achieved in low power diode pumped passively mode locked lasers with Nd,La:CaF2 and Nd,Y:SrF2 crystals. The pulses as short as 258 fs at wavelength of 1057 nm were obtained in the first case, while 5 ps long pulses at 1065 nm were generated from the second laser system.

miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pham, Hung; Department of Medicine, Veterans Affair Greater Los Angeles Healthcare System, Los Angeles, CA 90073; Ekaterina Rodriguez, C.

2013-09-13

Highlights: •Pancreatic cancer cells express low miR-143 levels and elevated p-MEK, p-MAPK and RREB1. •MEK inhibitors U0126 and PD98059 increase miR-143 expression. •miR-143 decreases COX-2 mRNA stability and expression and PGE{sub 2}. •miR-143 decreases p-p38MAPK, p-MEK, p-MAPK and RREB1 expression. -- Abstract: Small non-coding RNAs, microRNAs (miRNA), inhibit the translation or accelerate the degradation of message RNA (mRNA) by targeting the 3′-untranslated region (3′-UTR) in regulating growth and survival through gene suppression. Deregulated miRNA expression contributes to disease progression in several cancers types, including pancreatic cancers (PaCa). PaCa tissues and cells exhibit decreased miRNA, elevated cyclooxygenase (COX)-2 and increased prostaglandinmore » E{sub 2} (PGE{sub 2}) resulting in increased cancer growth and metastases. Human PaCa cell lines were used to demonstrate that restoration of miRNA-143 (miR-143) regulates COX-2 and inhibits cell proliferation. miR-143 were detected at fold levels of 0.41 ± 0.06 in AsPC-1, 0.20 ± 0.05 in Capan-2 and 0.10 ± 0.02 in MIA PaCa-2. miR-143 was not detected in BxPC-3, HPAF-II and Panc-1 which correlated with elevated mitogen-activated kinase (MAPK) and MAPK kinase (MEK) activation. Treatment with 10 μM of MEK inhibitor U0126 or PD98059 increased miR-143, respectively, by 187 ± 18 and 152 ± 26-fold in BxPC-3 and 182 ± 7 and 136 ± 9-fold in HPAF-II. miR-143 transfection diminished COX-2 mRNA stability at 60 min by 2.6 ± 0.3-fold in BxPC-3 and 2.5 ± 0.2-fold in HPAF-II. COX-2 expression and cellular proliferation in BxPC-3 and HPAF-II inversely correlated with increasing miR-143. PGE{sub 2} levels decreased by 39.3 ± 5.0% in BxPC-3 and 48.0 ± 3.0% in HPAF-II transfected with miR-143. Restoration of miR-143 in PaCa cells suppressed of COX-2, PGE{sub 2}, cellular proliferation and MEK/MAPK activation, implicating this pathway in regulating miR-143 expression.« less

21 CFR 516.143 - Written report.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the new animal drug for the proposed use in a minor species outweigh its risks to the target animal..., FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.143 Written report. The written report required in § 516...

21 CFR 516.143 - Written report.

Code of Federal Regulations, 2012 CFR

2012-04-01

... the new animal drug for the proposed use in a minor species outweigh its risks to the target animal..., FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.143 Written report. The written report required in § 516...

21 CFR 516.143 - Written report.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the new animal drug for the proposed use in a minor species outweigh its risks to the target animal..., FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.143 Written report. The written report required in § 516...

21 CFR 516.143 - Written report.

Code of Federal Regulations, 2013 CFR

2013-04-01

... the new animal drug for the proposed use in a minor species outweigh its risks to the target animal..., FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.143 Written report. The written report required in § 516...

21 CFR 516.143 - Written report.

Code of Federal Regulations, 2014 CFR

2014-04-01

... the new animal drug for the proposed use in a minor species outweigh its risks to the target animal..., FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally Marketed Unapproved New Animal Drugs for Minor Species § 516.143 Written report. The written report required in § 516...

26 CFR 1.4-3 - Husband and wife filing separate returns.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 1.4-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Normal Taxes and Surtaxes § 1.4-3 Husband and wife filing separate returns. (a) In general. If the... each elect to pay the optional tax imposed under section 3 or neither may so elect. If the separate...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

47 CFR 87.143 - Transmitter control requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 87.143 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO..., the control point for an automatically controlled enroute station is the computer facility which controls the transmitter. Any computer controlled transmitter must be equipped to automatically shut down...

Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse

PubMed Central

Bai, Ying; Zhang, Yuan; Hua, Jun; Yang, Xiangyu; Zhang, Xiaotian; Duan, Ming; Zhu, Xinjian; Huang, Wenhui; Chao, Jie; Zhou, Rongbin; Hu, Gang; Yao, Honghong

2016-01-01

MicroRNA-143 (miR-143) plays a critical role in various cellular processes; however, the role of miR-143 in the maintenance of blood-brain barrier (BBB) integrity remains poorly defined. Silencing miR-143 in a genetic animal model or via an anti-miR-143 lentivirus prevented the BBB damage induced by methamphetamine. miR-143, which targets p53 unregulated modulator of apoptosis (PUMA), increased the permeability of human brain endothelial cells and concomitantly decreased the expression of tight junction proteins (TJPs). Silencing miR-143 increased the expression of TJPs and protected the BBB integrity against the effects of methamphetamine treatment. PUMA overexpression increased the TJP expression through a mechanism that involved the NF-κB and p53 transcription factor pathways. Mechanistically, methamphetamine mediated up-regulation of miR-143 via sigma-1 receptor with sequential activation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3′ kinase (PI3K)/Akt and STAT3 pathways. These results indicated that silencing miR-143 could provide a novel therapeutic strategy for BBB damage-related vascular dysfunction. PMID:27767041

Deletion of the miR-143/145 Cluster Leads to Hydronephrosis in Mice

PubMed Central

Medrano, Silvia; Sequeira-Lopez, Maria Luisa S.; Gomez, R. Ariel

2015-01-01

Obstructive nephropathy, the leading cause of kidney failure in children, can be anatomic or functional. The underlying causes of functional hydronephrosis are not well understood. miRNAs, which are small noncoding RNAs, regulate gene expression at the post-transcriptional level. We found that miR-145-5p, a member of the miR-143/145 cluster that is highly expressed in smooth muscle cells of the renal vasculature, was present in the pelvicalyceal system and the ureter. To evaluate whether the miR-143/145 cluster is involved in urinary tract function we performed morphologic, functional, and gene expression studies in mice carrying a whole-body deletion of miR-143/145. miR-143/145–deficient mice developed hydronephrosis, characterized by severe papillary atrophy and dilatation of the pelvicalyceal system without obvious physical obstruction. Moreover, mutant mice showed abnormal ureteral peristalsis. The number of ureter contractions was significantly higher in miR-143/145–deficient mice. Peristalsis was replaced by incomplete, short, and more frequent contractions that failed to completely propagate in a proximal-distal direction. Microarray analysis showed 108 differentially expressed genes in ureters of miR-143/145–deficient mice. Ninety genes were up-regulated and 18 genes were down-regulated, including genes with potential regulatory roles in smooth muscle contraction and extracellular matrix-receptor interaction. We show that miR-143/145 are important for the normal peristalsis of the ureter and report an association between the expression of these miRNAs and hydronephrosis. PMID:25307343

A new luminous blue variable - R143 in 30 Doradus

NASA Technical Reports Server (NTRS)

Parker, Joel WM.; Clayton, Geoffrey C.; Winge, Claudia; Conti, Peter S.

1993-01-01

We have discovered that R143 in the Large Magellanic Cloud is a luminous blue variable (LBV), the first and perhaps the lone LBV in the central cluster of 30 Doradus, and only the sixth known LMC LBV. Photometric and spectroscopic observations over the past 40 yr indicate that during that time R143 moved redward (changing from an F5 to F8 supergiant), then blueward (possibly becoming as early as O9.5), and is now moving back to the red (currently appearing as a late B supergiant). Similarly, the V magnitude of the star has changed by at least 1.4 mag. Images of R143 show very unusual filaments of nebulosity extending from the star to a shell at a distance of 3.5 pc, perhaps due to a similar ejection mechanism that created the spiral jets and shell associated with AG Car, another LBV.

Global mining risk footprint of critical metals necessary for low-carbon technologies: the case of neodymium, cobalt, and platinum in Japan.

PubMed

Nansai, Keisuke; Nakajima, Kenichi; Kagawa, Shigemi; Kondo, Yasushi; Shigetomi, Yosuke; Suh, Sangwon

2015-02-17

Meeting the 2-degree global warming target requires wide adoption of low-carbon energy technologies. Many such technologies rely on the use of precious metals, however, increasing the dependence of national economies on these resources. Among such metals, those with supply security concerns are referred to as critical metals. Using the Policy Potential Index developed by the Fraser Institute, this study developed a new footprint indicator, the mining risk footprint (MRF), to quantify the mining risk directly and indirectly affecting a national economy through its consumption of critical metals. We formulated the MRF as a product of the material footprint (MF) of the consuming country and the mining risks of the countries where the materials are mined. A case study was conducted for the 2005 Japanese economy to determine the MF and MRF for three critical metals essential for emerging energy technologies: neodymium, cobalt and platinum. The results indicate that in 2005 the MFs generated by Japanese domestic final demand, that is, the consumption-based metal output of Japan, were 1.0 × 10(3) t for neodymium, 9.4 × 10(3) t for cobalt, and 2.1 × 10 t for platinum. Export demand contributes most to the MF, accounting for 3.0 × 10(3) t, 1.3 × 10(5) t, and 3.1 × 10 t, respectively. The MRFs of Japanese total final demand (domestic plus export) were calculated to be 1.7 × 10 points for neodymium, 4.5 × 10(-2) points for cobalt, and 5.6 points for platinum, implying that the Japanese economy is incurring a high mining risk through its use of neodymium. This country's MRFs are all dominated by export demand. The paper concludes by discussing the policy implications and future research directions for measuring the MFs and MRFs of critical metals. For countries poorly endowed with mineral resources, adopting low-carbon energy technologies may imply a shifting of risk from carbon resources to other natural resources, in particular critical metals, and a trade

33 CFR 143.210 - Letter of compliance.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Mobile Offshore Drilling Units § 143.210 Letter of compliance. (a) The Officer in Charge, Marine Inspection, determines whether a mobile offshore... of a foreign mobile offshore drilling unit requiring a letter of compliance examination must pay the...

33 CFR 143.120 - Floating OCS facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT OCS Facilities § 143.120 Floating OCS facilities... (Marine Engineering) and J (Electrical Engineering) of 46 CFR chapter I and 46 CFR part 108 (Design and Equipment). Where unusual design or equipment needs make compliance impracticable, alternative proposals...

Large-mode-area single-mode-output Neodymium-doped silicate glass all-solid photonic crystal fiber

PubMed Central

Li, Wentao; Chen, Danping; Qinling, Zhou; Hu, Lili

2015-01-01

We have demonstrated a 45 μm core diameter Neodymium-doped all-solid silicate glass photonic crystal fiber laser with a single mode laser output. The structure parameters and modes information of the fiber are both demonstrated by theoretical calculations using Finite Difference Time Domain (FDTD) method and experimental measurements. Maximum 0.8 W output power limited by launched pump power has been generated in 1064 nm with laser beam quality factor M2 1.18. PMID:26205850

28 CFR 0.143 - Incentive Award Program.

Code of Federal Regulations, 2010 CFR

2010-07-01

....143 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE... Justice Programs, the Director of the Executive Office for U.S. Attorneys, the Director of the Executive Office for U.S. Trustees, the Director of the Executive Office for Immigration Review, and the Director...

37 CFR 1.143 - Reconsideration of requirement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Inventions in One Application; Restriction § 1.143 Reconsideration of requirement. If the applicant disagrees... applicant must indicate a provisional election of one invention for prosecution, which invention shall be the one elected in the event the requirement becomes final The requirement for restriction will be...

47 CFR 101.143 - Minimum path length requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.143 Minimum path length requirements. (a) The... carrier fixed point-to-point microwave services must equal or exceed the value set forth in the table...

47 CFR 101.143 - Minimum path length requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.143 Minimum path length requirements. (a) The... carrier fixed point-to-point microwave services must equal or exceed the value set forth in the table...

47 CFR 101.143 - Minimum path length requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.143 Minimum path length requirements. (a) The... carrier fixed point-to-point microwave services must equal or exceed the value set forth in the table...

47 CFR 101.143 - Minimum path length requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.143 Minimum path length requirements. (a) The... carrier fixed point-to-point microwave services must equal or exceed the value set forth in the table...

47 CFR 101.143 - Minimum path length requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.143 Minimum path length requirements. (a) The... carrier fixed point-to-point microwave services must equal or exceed the value set forth in the table...

Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium.

PubMed

Willbold, Elmar; Gu, Xuenan; Albert, Devon; Kalla, Katharina; Bobe, Katharina; Brauneis, Maria; Janning, Carla; Nellesen, Jens; Czayka, Wolfgang; Tillmann, Wolfgang; Zheng, Yufeng; Witte, Frank

2015-01-01

Rare earth elements are promising alloying element candidates for magnesium alloys used as biodegradable devices in biomedical applications. Rare earth elements have significant effects on the high temperature strength as well as the creep resistance of alloys and they improve magnesium corrosion resistance. We focused on lanthanum, neodymium and cerium to produce magnesium alloys with commonly used rare earth element concentrations. We showed that low concentrations of rare earth elements do not promote bone growth inside a 750 μm broad area around the implant. However, increased bone growth was observed at a greater distance from the degrading alloys. Clinically and histologically, the alloys and their corrosion products caused no systematic or local cytotoxicological effects. Using microtomography and in vitro experiments, we could show that the magnesium-rare earth element alloys showed low corrosion rates, both in in vitro and in vivo. The lanthanum- and cerium-containing alloys degraded at comparable rates, whereas the neodymium-containing alloy showed the lowest corrosion rates. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

19 CFR 143.23 - Form of entry.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) SPECIAL ENTRY PROCEDURES Informal Entry § 143.23 Form of entry. Except for the types of... upper right hand corner. (g) Merchandise, regardless of value, which is imported for noncommercial... credit, Customs Form 7501, annotated “informal entry” in the upper right hand corner, and Customs Form...

40 CFR 98.143 - Calculating GHG emissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Glass Production § 98.143 Calculating GHG emissions. You must calculate and report the annual process CO2 emissions from each continuous glass melting furnace using the procedure in paragraphs (a) and (b) of this section. (a) For each continuous glass melting furnace that...

40 CFR 98.143 - Calculating GHG emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Glass Production § 98.143 Calculating GHG emissions. You must calculate and report the annual process CO2 emissions from each continuous glass melting furnace using the procedure in paragraphs (a) and (b) of this section. (a) For each continuous glass melting furnace that...

Reflection Asymmetric Shapes in the Neutron-Rich 140,143Ba Isotopes

NASA Astrophysics Data System (ADS)

Zhu Sheng-jiang (S, J. Zhu; Wang, Mu-ge; J, H. Hamilton; A, V. Ramayya; B, R. S. Babu; W, C. Ma; Long, Gui-lu; Deng, Jing-kang; Zhu, Ling-yan; Li, Ming; T, N. Ginter; J, Komicki; J, D. Cole; R, Aryaeinejad; Y, K. Dardenne; M, W. Drigert; J, O. Rasmussen; Ts, Yu Oganessian; M, A. Stoyer; S, Y. Chu; K, E. Gregorich; M, F. Mohar; S, G. Prussin; I, Y. Lee; N, R. Johnson; F, K. McGowan

1997-08-01

Level schemes for the neutron-rich 140,143Ba nuclei have been determined by study of prompt γ-rays in spontaneous fission of 252Cf. The level pattern and enhanced E1 transitions between π = + and π = - bands show reflection asymmetric shapes with simplex quantum number s = +1 in 140Ba and s = ±i in 143Ba, respectively. The octupole deformation stability with spin variation has been discussed.

Mutant N143P Reveals How Na[superscript +] Activates Thrombin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Niu, Weiling; Chen, Zhiwei; Bush-Pelc, Leslie A.

2010-01-12

The molecular mechanism of thrombin activation by Na{sup +} remains elusive. Its kinetic formulation requires extension of the classical Botts-Morales theory for the action of a modifier on an enzyme to correctly account for the contribution of the E*, E, and E:Na{sup +} forms. The extended scheme establishes that analysis of k{sub cat} unequivocally identifies allosteric transduction of Na{sup +} binding into enhanced catalytic activity. The thrombin mutant N143P features no Na{sup +}-dependent enhancement of k{sub cat} yet binds Na{sup +} with an affinity comparable to that of wild type. Crystal structures of the mutant in the presence and absencemore » of Na{sup +} confirm that Pro{sup 143} abrogates the important H-bond between the backbone N atom of residue 143 and the carbonyl O atom of Glu{sup 192}, which in turn controls the orientation of the Glu{sup 192}-Gly{sup 193} peptide bond and the correct architecture of the oxyanion hole. We conclude that Na{sup +} activates thrombin by securing the correct orientation of the Glu{sup 192}-Gly{sup 193} peptide bond, which is likely flipped in the absence of cation. Absolute conservation of the 143-192 H-bond in trypsin-like proteases and the importance of the oxyanion hole in protease function suggest that this mechanism of Na{sup +} activation is present in all Na{sup +}-activated trypsin-like proteases.« less

Interaction between G Protein-Coupled Receptor 143 and Tyrosinase: Implications for Understanding Ocular Albinism Type 1.

PubMed

De Filippo, Elisabetta; Schiedel, Anke C; Manga, Prashiela

2017-02-01

Developmental eye defects in X-linked ocular albinism type 1 are caused by G-protein coupled receptor 143 (GPR143) mutations. Mutations result in dysfunctional melanosome biogenesis and macromelanosome formation in pigment cells, including melanocytes and retinal pigment epithelium. GPR143, primarily expressed in pigment cells, localizes exclusively to endolysosomal and melanosomal membranes unlike most G protein-coupled receptors, which localize to the plasma membrane. There is some debate regarding GPR143 function and elucidating the role of this receptor may be instrumental for understanding neurogenesis during eye development and for devising therapies for ocular albinism type I. Many G protein-coupled receptors require association with other proteins to function. These G protein-coupled receptor-interacting proteins also facilitate fine-tuning of receptor activity and tissue specificity. We therefore investigated potential GPR143 interaction partners, with a focus on the melanogenic enzyme tyrosinase. GPR143 coimmunoprecipitated with tyrosinase, while confocal microscopy demonstrated colocalization of the proteins. Furthermore, tyrosinase localized to the plasma membrane when coexpressed with a GPR143 trafficking mutant. The physical interaction between the proteins was confirmed using fluorescence resonance energy transfer. This interaction may be required in order for GPR143 to function as a monitor of melanosome maturation. Identifying tyrosinase as a potential GPR143 binding protein opens new avenues for investigating the mechanisms that regulate pigmentation and neurogenesis. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

17 CFR 143.9 - Administrative wage garnishment orders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Administrative wage... JURISDICTION Administrative Wage Garnishment § 143.9 Administrative wage garnishment orders. Whenever an... administrative wage garnishment proceeding against a delinquent debtor. ...

27 CFR 646.143 - Meaning of terms.

Code of Federal Regulations, 2013 CFR

2013-04-01

... bill which states the quantity, source, and destination of the cigarettes; (e) Licensed or otherwise... CIGARETTES General § 646.143 Meaning of terms. When used in this part, terms are defined as follows in this... used with respect to a distributor, the property on which the cigarettes are kept or stored. The...

27 CFR 646.143 - Meaning of terms.

Code of Federal Regulations, 2011 CFR

2011-04-01

... bill which states the quantity, source, and destination of the cigarettes; (e) Licensed or otherwise... CIGARETTES General § 646.143 Meaning of terms. When used in this part, terms are defined as follows in this... used with respect to a distributor, the property on which the cigarettes are kept or stored. The...

27 CFR 646.143 - Meaning of terms.

Code of Federal Regulations, 2012 CFR

2012-04-01

... bill which states the quantity, source, and destination of the cigarettes; (e) Licensed or otherwise... CIGARETTES General § 646.143 Meaning of terms. When used in this part, terms are defined as follows in this... used with respect to a distributor, the property on which the cigarettes are kept or stored. The...

27 CFR 646.143 - Meaning of terms.

Code of Federal Regulations, 2014 CFR

2014-04-01

... bill which states the quantity, source, and destination of the cigarettes; (e) Licensed or otherwise... CIGARETTES General § 646.143 Meaning of terms. When used in this part, terms are defined as follows in this... used with respect to a distributor, the property on which the cigarettes are kept or stored. The...

27 CFR 646.143 - Meaning of terms.

Code of Federal Regulations, 2010 CFR

2010-04-01

... bill which states the quantity, source, and destination of the cigarettes; (e) Licensed or otherwise... CIGARETTES General § 646.143 Meaning of terms. When used in this part, terms are defined as follows in this... used with respect to a distributor, the property on which the cigarettes are kept or stored. The...

Liquid-liquid extraction of neodymium(III) by dialkylphosphate ionic liquids from acidic medium: the importance of the ionic liquid cation.

PubMed

Rout, Alok; Kotlarska, Justyna; Dehaen, Wim; Binnemans, Koen

2013-10-21

The ionic liquids 1-hexyl-3-methylimidazolium bis(2-ethylhexyl)phosphate, [C6mim][DEHP], 1-hexyl-1-methylpyrrolidinium bis(2-ethylhexyl)phosphate, [C6mpyr][DEHP], and tetrabutylammonium bis(2-ethylhexyl)phosphate, [N4444][DEHP], were prepared and characterized using (1)H and (13)C NMR spectroscopy. The extraction behavior of neodymium(iii) from nitrate medium by these ionic liquids, diluted with the room temperature ionic liquids 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, [C6mim][NTf2], 1-hexyl-3-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide, [C6mpyr][NTf2], and tributylmethylammonium bis(trifluoromethylsulfonyl)imide, [N1444][NTf2], was studied. The distribution ratio of neodymium(iii) was measured as a function of various parameters, such as pH, concentration of the ionic liquid extractant, nature of diluents, concentration of ionic liquid cations and nitrate anions in the aqueous phase. The extraction behavior was compared with that obtained for a solution of the molecular extractant bis(2-ethylhexyl)phosphoric acid (DEHPA) in an ionic liquid diluent. The extraction of neodymium(iii) in the ionic liquids [C6mim][DEHP] and [C6mpyr][DEHP] showed markedly different extraction properties in comparison with that of the quaternary ammonium analogue [N4444][DEHP], especially concerning the pH dependence of the extraction process. These results show that the extraction process can be tuned by the selection of the ionic liquid cation. The extraction experiments also included the trivalent rare-earth ions lanthanum(iii), cerium(iii), praseodymium(iii), ytterbium(iii) and yttrium(iii). Studies of the stripping behavior and the reusability of the ionic liquids were carried out, which indicate that the ionic liquids can be reused with no loss in activity.

34 CFR 300.143 - Separate classes prohibited.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Private Schools § 300.143 Separate classes prohibited. An LEA may not use funds available under section 611 or 619 of the Act for classes that are organized separately on the basis of school enrollment or religion of the children if—' (a) The classes are at the same site; and (b) The classes include children...

34 CFR 300.143 - Separate classes prohibited.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Private Schools § 300.143 Separate classes prohibited. An LEA may not use funds available under section 611 or 619 of the Act for classes that are organized separately on the basis of school enrollment or religion of the children if—' (a) The classes are at the same site; and (b) The classes include children...

34 CFR 300.143 - Separate classes prohibited.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Private Schools § 300.143 Separate classes prohibited. An LEA may not use funds available under section 611 or 619 of the Act for classes that are organized separately on the basis of school enrollment or religion of the children if—' (a) The classes are at the same site; and (b) The classes include children...

34 CFR 300.143 - Separate classes prohibited.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Private Schools § 300.143 Separate classes prohibited. An LEA may not use funds available under section 611 or 619 of the Act for classes that are organized separately on the basis of school enrollment or religion of the children if—' (a) The classes are at the same site; and (b) The classes include children...

Eastern Indian 3800-million-year-old crust and early mantle differentiation

USGS Publications Warehouse

Basu, A.R.; Ray, S.L.; Saha, A.K.; Sarkar, S.N.

1981-01-01

Samarium-neodymium data for nine granitic and tonalite gneisses occurring as remnants within the Singhbhum granite batholith in eastern India define an isochron of age 3775 ?? 89 ?? 106 years with an initial 143Nd/144Nd ratio of 0.50798 ?? 0.00007. This age contrasts with the rubidium-strontium age of 3200 ?? 106 years for the same suite of rocks. On the basis of the new samarium-neodynium data, field data, and petrologic data, a scheme of evolution is proposed for the Archean crust in eastern India. The isotopic data provide evidence that parts of the earth's mantle were already differentiated with respect to the chondritic samarium-neodymium ratio 3800 ?? 106 years ago.

Mitigation of arsenic-induced acquired cancer phenotype in prostate cancer stem cells by miR-143 restoration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ngalame, Ntube N.O., E-mail: ngalamenn@niehs.nih.g

Inorganic arsenic, an environmental contaminant and a human carcinogen is associated with prostate cancer. Emerging evidence suggests that cancer stem cells (CSCs) are the driving force of carcinogenesis. Chronic arsenic exposure malignantly transforms the human normal prostate stem/progenitor cell (SC) line, WPE-stem to arsenic-cancer SCs (As-CSCs), through unknown mechanisms. MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the posttranscriptional level. In prior work, miR-143 was markedly downregulated in As-CSCs, suggesting a role in arsenic-induced malignant transformation. In the present study, we investigated whether loss of miR-143 expression is important in arsenic-induced transformation of prostate SCs. Restorationmore » of miR-143 in As-CSCs was achieved by lentivirus-mediated miR-143 overexpression. Cells were assessed bi-weekly for up to 30 weeks to examine mitigation of cancer phenotype. Secreted matrix metalloproteinase (MMP) activity was increased by arsenic-induced malignant transformation, but miR-143 restoration decreased secreted MMP-2 and MMP-9 enzyme activities compared with scramble controls. Increased cell proliferation and apoptotic resistance, two hallmarks of cancer, were decreased upon miR-143 restoration. Increased apoptosis was associated with decreased BCL2 and BCL-XL expression. miR-143 restoration dysregulated the expression of SC/CSC self-renewal genes including NOTCH-1, BMI-1, OCT4 and ABCG2. The anticancer effects of miR-143 overexpression appeared to be mediated by targeting and inhibiting LIMK1 protein, and the phosphorylation of cofilin, a LIMK1 substrate. These findings clearly show that miR-143 restoration mitigated multiple cancer characteristics in the As-CSCs, suggesting a potential role in arsenic-induced transformation of prostate SCs. Thus, miR-143 is a potential biomarker and therapeutic target for arsenic-induced prostate cancer. - Highlights: • Chronic arsenic exposure

Power scaling of diode-pumped neodymium yttrium aluminum borate laser

NASA Technical Reports Server (NTRS)

Hemmati, Hamid

1991-01-01

Preliminary results are presented of the efficient diode-pumped operation of a neodymium yttrium aluminum borate (NYAB) laser at 531.5 nm using two 1-W diode-laser arrays for the pump. With 1380 mW of CW power incident on the crystal, as much as 51 mW of 532.5-nm laser radiation was obtained with the unoptimized cavity. The corresponding optical-to-optical conversion efficiency was 3.7 percent. A plot of the output 531.5 nm vs incident 807 nm pump power is shown. The crystal output power was critically dependent on the rotational and translational adjustment of the NYAB crystal inside the cavity. It is suggested that a crystal cut at the exact phase matching angle, placed in a cavity with proper optimal reflection and transmission mirror coatings, and pumped at proper wavelength can result in higher output power. Thus, the NYAB output power approaches that of a CW intracavity frequency doubled Nd:YAG laser.

Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate.

PubMed

Sertan-de Guzman, Alice A; Predicala, Rey Z; Bernardo, Evelyn B; Neilan, Brett A; Elardo, Sheila P; Mangalindan, Gina C; Tasdemir, Deniz; Ireland, Chris M; Barraquio, Wilfredo L; Concepcion, Gisela P

2007-12-01

Microbial isolate Z143-1 found to be associated with an unidentified tunicate was characterized due to its significant antimicrobial activity. Z143-1 is similar to Pseudovibrio ascidiaceicola and Pseudovibrio denitrificans in morphological, physiological and biochemical characteristics, except for its ability to ferment glucose and produce a characteristic red pigment. Fatty acid methyl ester analysis revealed a predominance of the fatty acid 18:1 omega7c at 80.55%, at levels slightly lower than the Pseudovibrio denitrificans type strain DN34(T) (87.7%). The mol% G+C of Z143-1 is 54.02, relatively higher than the Pseudovibrio denitrificans type strain DN34(T) and Pseudovibrio ascidiaceicola with mol% G+C of 51.7 and 51.4, respectively. However, phylogenetic analysis of the 16S rRNA gene sequence of Z143-1 showed 100% similarity with the Pseudovibrio denitrificans type strain DN34(T). In this study, the bacterium Z143-1 is reported as a new strain of Pseudovibrio denitrificans. While there is no report of a secondary metabolite for Pseudovibrio denitrificans, Z143-1 produces the red pigment heptylprodigiosin, also known as 16-methyl-15-heptyl-prodiginine, which shows anti-Staphylococcus aureus activity.

19 CFR 143.21 - Merchandise eligible for informal entry.

Code of Federal Regulations, 2010 CFR

2010-04-01

...; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Informal Entry § 143.21 Merchandise eligible....00, 9810.00.05, HTSUS (19 U.S.C. 1202), imported by a library or other institution described in...

Electrochemistry and the mechanisms of nucleation and growth of neodymium during electroreduction from LiCl-KCl eutectic salts on Mo substrate

NASA Astrophysics Data System (ADS)

Tang, Hao; Pesic, Batric

2015-03-01

The electrochemical behavior of NdCl3 was studied on a Mo electrode in molten LiCl-KCl eutectic salts. The electroreduction of Nd(III)/Nd(0) involved two reaction steps, as confirmed by three different electrochemical techniques. In the first reaction step, Nd(III) is converted into soluble Nd(II), which undergoes further reduction into metallic Nd(0) in the second reaction step. The standard reaction rate constants for each reaction step were determined by Nicholson method. The rate constant values were used in Matsuda-Ayabe's criteria for testing the electrochemical reversibility. Accordingly, both reaction steps were quasi-reversible redox reactions. The nucleation mechanisms of neodymium metal deposited on a Mo substrate were predicted by using Scharifker-Hill model, and tested for the first time by scanning electron microscopy (SEM) studies of the electrode surface. The SEM studies confirmed that for the low initial concentration of NdCl3, neodymium nucleates and grows progressively, while for higher NdCl3 concentrations, the related mechanism is instantaneous. Both are governed by the aggregative growth mechanisms based on surface mobility of formed nanoclusters.

Neodymium, strontium and chromium isotopic studies of the LEW86010 and Angra dos Reis meteorites and the chronology of the angrite parent body

NASA Technical Reports Server (NTRS)

Nyquist, L. E.; Bansal, B.; Wiesmann, H.; Shih, C.-Y.

1994-01-01

Neodymium, stontium, and chromium isotopic studies of the LEW86010 angrite established its absolute age and the formation interval between its crystallization and condensation of Allende CAIs from the solar nebula. Pyroxene and phosphate were found to contain approximately 8% of its Sm and Nd inventory. A conventional Sm-147-Nd-143 isochron yielded an age of 4.53 +/- 0.04 Ga (2 sigma and Epsilon(sub Nd sup 143)) = 0.45 +/- 1.1. An Sm-146-Nd-142 isochron gives initial Sm-146/Sm-144 = 0.0076 +/- 0.0009 and Epsilon (sub Nd sup 142) = -2.5 +/- 0.4. The Rb-Sr analyses give initial Sr-87/Sr-86 Iota(sub Sr sup 87) = 0.698972 +/- 8 and 0.698970 +/- 18 for LEW and ADOR, respectively, relative to Sr-87/Sr-86 = 0.71025 for NBS987. The difference, Delta Iota(sub Sr Sup 87), between Iota (sub sr sup 87) for the angrites and literature values for Allende CAIs, corresponds to approximately Ma of growth in a solar nebula with a CI chondrite value of Rb-87/Sr-86 = 0.91, or approximately 5 Ma in a nebula with solar photospheric Rb-87/Sr-86 = 1.51. Excess Cr-53 from extinct Mn-53(t(sub 1/2) = 3.7 Ma)in LEW86010 corresponds to initial Mn-53/Mn-55 = 4.4 +/- 1.0 x 10(exp -5) for the inclusions as previously reported by the Paris group (Birck and Allegre, 1988). The Sm-146/Sm-144 value found for LEW86010 corresponds to solar system initial (Sm-146/Sm-144) = 0.0080 +/- 0.0009 for crystallization 8 Ma after Allende, the difference between Pb-Pb ages of angrites and Allende, or 0.0086 +/- 0.0009 for crystallation 18 Ma after Allende, using the Mn-Cr formation interval. The isotopic data are discussed in the context of a model in which an undifferentiated 'chondritic' parent body formed from the solar nebula approximately Ma after Allende CAIs and subsequently underwent differentiation accompanied by loss of volatiles. Parent bodies with Rb/Sr similar to that of CI, CM, or CO chondrites could satisfy the Cr and Sr isotopic systematics. If the angrite parent body had Rb/Sr similar to that of

Developing a Magnetic Circular Dichroism Apparatus Equipped with Neodymium Magnet for Students to Investigate the Electronic Structures of Transition Metals and Lanthanoids

ERIC Educational Resources Information Center

Yakubu, Abdallah; Suzuki, Takayoshi; Kita, Masakazu

2017-01-01

This paper describes the development of a simple magnetic circular dichroism (MCD) apparatus from a wood base and neodymium magnets and its configuration in the Faraday alignment. The applicability and effectiveness of the apparatus for MCD spectra measurements have been examined. The apparatus was used by undergraduate students to conduct MCD…

Publications - GMC 143 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 143 Publication Details Title: Total organic carbon, rock-eval pyrolysis, and vitrinite Reference Unknown, 1989, Total organic carbon, rock-eval pyrolysis, and vitrinite reflectance data of Organic Carbon; Vitrinite Reflectance Top of Page Department of Natural Resources, Division of Geological

40 CFR 267.143 - Financial assurance for closure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Financial assurance for closure. 267... PERMIT Financial Requirements § 267.143 Financial assurance for closure. The owner or operator must establish financial assurance for closure of each storage or treatment unit that he owns or operates. In...

Age-related changes in miR-143-3p:Igfbp5 interactions affect muscle regeneration.

PubMed

Soriano-Arroquia, Ana; McCormick, Rachel; Molloy, Andrew P; McArdle, Anne; Goljanek-Whysall, Katarzyna

2016-04-01

A common characteristic of aging is defective regeneration of skeletal muscle. The molecular pathways underlying age-related decline in muscle regenerative potential remain elusive. microRNAs are novel gene regulators controlling development and homeostasis and the regeneration of most tissues, including skeletal muscle. Here, we use satellite cells and primary myoblasts from mice and humans and an in vitro regeneration model, to show that disrupted expression of microRNA-143-3p and its target gene, Igfbp5, plays an important role in muscle regeneration in vitro. We identified miR-143 as a regulator of the insulin growth factor-binding protein 5 (Igfbp5) in primary myoblasts and show that the expression of miR-143 and its target gene is disrupted in satellite cells from old mice. Moreover, we show that downregulation of miR-143 during aging may act as a compensatory mechanism aiming at improving myogenesis efficiency; however, concomitant upregulation of miR-143 target gene, Igfbp5, is associated with increased cell senescence, thus affecting myogenesis. Our data demonstrate that dysregulation of miR-143-3p:Igfbp5 interactions in satellite cells with age may be responsible for age-related changes in satellite cell function. © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

33 CFR 143.401 - Vessel certification and operation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.401... that the standby vessel is designated to assist. Crew spaces may be used to meet the requirements of... persons on the most populated facility that the standby vessel is designated to assist. Crew spaces may be...

33 CFR 143.401 - Vessel certification and operation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.401... that the standby vessel is designated to assist. Crew spaces may be used to meet the requirements of... persons on the most populated facility that the standby vessel is designated to assist. Crew spaces may be...

33 CFR 143.401 - Vessel certification and operation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.401... that the standby vessel is designated to assist. Crew spaces may be used to meet the requirements of... persons on the most populated facility that the standby vessel is designated to assist. Crew spaces may be...

33 CFR 143.401 - Vessel certification and operation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.401... that the standby vessel is designated to assist. Crew spaces may be used to meet the requirements of... persons on the most populated facility that the standby vessel is designated to assist. Crew spaces may be...

33 CFR 143.401 - Vessel certification and operation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Standby Vessels § 143.401... that the standby vessel is designated to assist. Crew spaces may be used to meet the requirements of... persons on the most populated facility that the standby vessel is designated to assist. Crew spaces may be...

40 CFR 265.143 - Financial assurance for closure.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., except as provided in § 265.143(f), divided by the number of years in the pay-in period. (ii) Subsequent... bills for partial or final closure activities, the Regional Administrator will instruct the trustee to... facility over its remaining operating life. Within 60 days after receiving bills for closure activities...

40 CFR 264.143 - Financial assurance for closure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... in § 264.143(g), divided by the number of years in the pay-in period. Subsequent payments must be... for partial or final closure activities, the Regional Administrator will instruct the trustee to make... operating life. Within 60 days after receiving bills for closure activities, the Regional Administrator will...

Concentrations and isotopic compositions of neodymium in the eastern Indian Ocean and Indonesian straits

NASA Astrophysics Data System (ADS)

Jeandel, Catherine; Thouron, Danièle; Fieux, Michèle

1998-08-01

Four profiles of Nd concentration and isotopic composition were determined at two stations in the eastern Indian Ocean along a north/south section between Bali and Port-Hedland and at two others in the Timor and Sumba straits. Neodymium concentrations increase with depth, between 7.2 pmol/L at the surface to 41.7 pmol/L close to the bottom. The ɛ Nd of the different water masses along the section are -7.2 ± 0.2 for the Indian Bottom Waters and -6.1 ± 0.2 for the Indian Deep Waters. The intermediate and thermocline waters are less radiogenic at st-10 than at st-20 (-5.3 ± 0.3 and -3.6 ± 0.2, respectively). In the Timor Passage and Sumba Strait, ɛ Nd of the Indonesian waters is -4.1 ± 0.2 and that of the North Indian Intermediate Waters is -2.6 ± 0.3. These distinct isotopic signals constrain the origins of the different water masses sampled in the eastern Indian Ocean. They fix the limit of the nonradiogenic Antarctic and Indian contributions to the southern part of the section whereas the northern part is influenced by radiogenic Indonesian flows. In addition, the neodymium isotopic composition suggests that in the north, deep waters are influenced by a radiogenic component originating from the Sunda Arch Slope flowing deeper than 1200 m, which was not documented previously. Mixing calculations assess the conservativity of ɛ Nd on the scale of an oceanic basin. The origin of the surprising radiogenic signal of the NIIW is discussed and could result from a remobilization of Nd sediment-hosted on the Java shelf, requiring important dissolved/particulate exchange processes. Such processes, occurring in specific areas, could play an important role in the world ocean Nd budget.

Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients.

PubMed

Nagai, Noriaki; Mano, Yu; Otake, Hiroko; Shibata, Teppei; Kubo, Eri; Sasaki, Hiroshi

2017-06-01

We investigated the accumulation of amyloid β (Aβ1-40, Aβ1-42, Aβ1-43) in the lens epithelium of patients with opacification of five different types (cortical cataract [COR]; nuclear cataract [NUC]; posterior subcapsular cataract [PSC]; retrodots [RD]; and water clefts [WC]). Samples were collected from Japanese patients taken during cataract surgery; Aβ levels and mRNA expression were determined by ELISA and a real-time RT-PCR method, respectively. Levels of Aβ1-40 and Aβ1-42 in the lens epithelium of patients with COR, NUC, PSC, RD, and WC showed no significant differences in comparison with transparent lens epithelium. Levels of Aβ1-43 in the lens epithelium of patients with PSC and WC were not detected, and NUC and RD were slightly elevated. In contrast to the results in these cataract types, high Aβ1-43 levels were observed in the lens epithelium of patients with COR, and a close relationship was observed between Aβ1-43 levels and the degree of lens opacification (R = 0.8229, n = 6). The levels of Aβ1-43 were also higher in the lens epithelium of patients with mixed-cataract showing cortical opacification, and the Aβ1-43 levels in the lens epithelium of mixed-cataract patients with cortical opacification was significantly higher than in that of mixed-cataract patients without cortical opacification. In addition, the level of an amyloid precursor protein mRNA in the lens epithelium of mixed-cataract patients with cortical opacification was significantly higher than in transparent lens and mixed-cataract patients without cortical opacification. We found high levels of Aβ1-43 accumulation in the lens epithelium of Japanese patients with cortical opacification.

13 CFR 143.12 - Special grant or subgrant conditions for “high-risk” grantees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Special grant or subgrant conditions for âhigh-riskâ grantees. 143.12 Section 143.12 Business Credit and Assistance SMALL BUSINESS... or subgrantee: (1) Has a history of unsatisfactory performance, or (2) Is not financially stable, or...

[miR-143 inhibits cell proliferation through targeted regulating the expression of K-ras gene in HeLa cells].

PubMed

Qin, H X; Cui, H K; Pan, Y; Hu, R L; Zhu, L H; Wang, S J

2016-12-23

Objective: To explore the effect of microRNA miR-143 on the proliferation of cervical cancer HeLa cells through targeted regulating the expression of K-ras gene. Methods: The luciferase report carrier containing wild type 3'-UTR of K-ras gene (K-ras-wt) or mutated 3'-UTR of the K-ras (K-ras-mut) were co-transfected with iR-143 mimic into the HeLa cells respectively, and the targeting effect of miR-143 in the transfectants was verified by the dual luciferase report system. HeLa cells were also transfected with miR-143 mimic (miR-143 mimic group), mimic control (negative control group), and miR-143 mimic plus K-ras gene (miR-143 mimic+ K-ras group), respectively. The expression of miR-143 in the transfected HeLa cells was detected by real-time PCR (RT-PCR), and the expression of K-ras protein was detected by Western blot. The cell proliferation activity of each group was examined by MTT assay. In addition, human cervical cancer tissue samples ( n =5) and cervical intraepithelial neoplasia tissue samples ( n =5) were also examined for the expression of miR-143 and K-ras protein by RT-PCR and Western blot, respectively. Results: The luciferase report assay showed that co-transfection with miR-143 mimic decreased the luciferase activity of the K-ras-wt significantly, but did not inhibit the luciferase activity of the K-ras-mut. The expression of miR-143 in the HeLa cells transfected with miR-143 mimic was significantly higher than that in the HeLa cells transfected with the mimic control (3.31±0.45 vs 0.97±0.22, P <0.05). The MTT assay revealed that the cell proliferative activity of the miR-143 mimic group was significantly lower than that of the negative control group ( P <0.05), and the cell proliferative activity of the miR-143 mimic+ K-ras group was also significantly lower than the control group ( P <0.05) but higher than the miR-143 mimic group significantly ( P <0.05). The expression levels of K-ras protein in the miR-143 mimic group, the negative control

Neodymium in the oceans: a global database, a regional comparison and implications for palaeoceanographic research

PubMed Central

Griffiths, Alexander M.; Lambelet, Myriam; Little, Susan H.; Stichel, Torben; Wilson, David J.

2016-01-01

The neodymium (Nd) isotopic composition of seawater has been used extensively to reconstruct ocean circulation on a variety of time scales. However, dissolved neodymium concentrations and isotopes do not always behave conservatively, and quantitative deconvolution of this non-conservative component can be used to detect trace metal inputs and isotopic exchange at ocean–sediment interfaces. In order to facilitate such comparisons for historical datasets, we here provide an extended global database for Nd isotopes and concentrations in the context of hydrography and nutrients. Since 2010, combined datasets for a large range of trace elements and isotopes are collected on international GEOTRACES section cruises, alongside classical nutrient and hydrography measurements. Here, we take a first step towards exploiting these datasets by comparing high-resolution Nd sections for the western and eastern North Atlantic in the context of hydrography, nutrients and aluminium (Al) concentrations. Evaluating those data in tracer–tracer space reveals that North Atlantic seawater Nd isotopes and concentrations generally follow the patterns of advection, as do Al concentrations. Deviations from water mass mixing are observed locally, associated with the addition or removal of trace metals in benthic nepheloid layers, exchange with ocean margins (i.e. boundary exchange) and/or exchange with particulate phases (i.e. reversible scavenging). We emphasize that the complexity of some of the new datasets cautions against a quantitative interpretation of individual palaeo Nd isotope records, and indicates the importance of spatial reconstructions for a more balanced approach to deciphering past ocean changes. This article is part of the themed issue ‘Biological and climatic impacts of ocean trace element chemistry’. PMID:29035258

Effect Of Neodymium Substitution In Structural Characteristics Of Magnesium Ferrite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thankachan, Smitha; Binu, P. J.; Xavier, Sheena

2011-10-20

The effect of Nd{sup 3+} substitution on the structural properties of Magnesium ferrite was studied in the series MgNd{sub x}Fe{sub 2-x}O{sub 4}, where x = 0 to 0.3 in steps of 0.05. The series was prepared by sol-gel technique which is one of the novel technique to prepare nanosized samples. Structural characterization was done using X-ray diffractometer and Fourier Transform Infrared Spectrometer. XRD analysis reveals the prepared samples are single phasic till x = 0.2. From x0 = .25, a secondary phase of iron neodymium oxide appears along with the spinel phase. Particle size calculation shows the prepared samples aremore » in the 9nm to 11 nm regime. Lattice parameter was found to increase with concentration of Nd. XRD and FTIR analysis confirmed spinel structure of the prepared samples. XRF result shows the expected composition of prepared samples. The frequency dependence of the dielectric constant in the range 100 Hz--120MHz was also studied« less

Global flows of critical metals necessary for low-carbon technologies: the case of neodymium, cobalt, and platinum.

PubMed

Nansai, Keisuke; Nakajima, Kenichi; Kagawa, Shigemi; Kondo, Yasushi; Suh, Sangwon; Shigetomi, Yosuke; Oshita, Yuko

2014-01-01

This study, encompassing 231 countries and regions, quantifies the global transfer of three critical metals (neodymium, cobalt, and platinum) considered vital for low-carbon technologies by means of material flow analysis (MFA), using trade data (BACI) and the metal contents of trade commodities, resolving the optimization problem to ensure the material balance of the metals within each country and region. The study shows that in 2005 international trade led to global flows of 18.6 kt of neodymium, 154 kt of cobalt, and 402 t of platinum and identifies the main commodities and top 50 bilateral trade links embodying these metals. To explore the issue of consumption efficiency, the flows were characterized according to the technological level of each country or region and divided into three types: green ("efficient use"), yellow ("moderately efficient use"), and red ("inefficient use"). On this basis, the shares of green, yellow, and red flows in the aggregate global flow of Nd were found to be 1.2%, 98%, and 1.2%, respectively. For Co, the respective figures are 53%, 28%, and 19%, and for Pt 15%, 84%, and 0.87%. Furthermore, a simple indicator focusing on the composition of the three colored flows for each commodity was developed to identify trade commodities that should be prioritized for urgent technical improvement to reduce wasteful use of the metals. Based on the indicator, we discuss logical, strategic identification of the responsibilities and roles of the countries involved in the global flows.

Efficient eye-safe neodymium doped composite yttrium gallium garnet crystal laser.

PubMed

Yu, Haohai; Wang, Shuxian; Han, Shuo; Wu, Kui; Su, Liangbi; Zhang, Huaijin; Wang, Zhengping; Xu, Jun; Wang, Jiyang

2014-03-15

We report a laser-diode pumped continuous-wave (cw) and passively Q-switched eye-safe laser at about 1.42 μm with the neodymium-doped yttrium gallium garnet (Nd:YGG) crystal for the first time to our knowledge. The composite Nd:YGG crystal was developed originally. A systematic comparison of laser performance between the homogeneously doped and composite Nd:YGG crystal was made, which showed that the composite Nd:YGG manifested less thermally induced effects. Cw output power of 2.06 W was obtained with the slope efficiency of 20.7%. With a V:YAG as a saturable absorber, the passive Q-switching at 1.42 μm was gotten with the pulse width, pulse energy, and peak power of 34 ns, 46.7 μJ, and 1.4 kW, respectively. The present work should provide a potential candidate for the generation of eye-safe lasers.

41 CFR 105-53.143 - Information Resources Management Service.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Information Resources... FUNCTIONS Central Offices § 105-53.143 Information Resources Management Service. (a) Creation and authority. The Information Resources Management Service (IRMS), headed by the Commissioner, Information Resources...

41 CFR 105-53.143 - Information Resources Management Service.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Information Resources... FUNCTIONS Central Offices § 105-53.143 Information Resources Management Service. (a) Creation and authority. The Information Resources Management Service (IRMS), headed by the Commissioner, Information Resources...

41 CFR 105-53.143 - Information Resources Management Service.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Information Resources... FUNCTIONS Central Offices § 105-53.143 Information Resources Management Service. (a) Creation and authority. The Information Resources Management Service (IRMS), headed by the Commissioner, Information Resources...

41 CFR 105-53.143 - Information Resources Management Service.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Information Resources... FUNCTIONS Central Offices § 105-53.143 Information Resources Management Service. (a) Creation and authority. The Information Resources Management Service (IRMS), headed by the Commissioner, Information Resources...

41 CFR 105-53.143 - Information Resources Management Service.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Information Resources... FUNCTIONS Central Offices § 105-53.143 Information Resources Management Service. (a) Creation and authority. The Information Resources Management Service (IRMS), headed by the Commissioner, Information Resources...

42 CFR 410.143 - Requirements for approved accreditation organizations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Diabetes Self-Management Training and Diabetes Outcome Measurements § 410.143 Requirements for approved... organization approved and recognized by CMS must undertake the following activities on an ongoing basis: (1... procedures: (1) Equivalency review. CMS compares the organization's standards and its application and...

GS143, an I{kappa}B ubiquitination inhibitor, inhibits allergic airway inflammation in mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hirose, Koichi; Wakashin, Hidefumi; Oki, Mie

2008-09-26

Asthma is characterized by airway inflammation with intense eosinophil infiltration and mucus hyper-production, in which antigen-specific Th2 cells play critical roles. Nuclear factor-{kappa}B (NF-{kappa}B) pathway has been demonstrated to be essential for the production of Th2 cytokines and chemokines in the airways in murine asthma models. In the present study, we examined the effect of GS143, a novel small-molecule inhibitor of I{kappa}B ubiquitination, on antigen-induced airway inflammation and Th2 cytokine production in mice. Intranasal administration of GS143 prior to antigen challenge suppressed antigen-induced NF-{kappa}B activation in the lung of sensitized mice. Intranasal administration of GS143 also inhibited antigen-induced eosinophil andmore » lymphocyte recruitment into the airways as well as the expression of Th2 cytokines and eotaxin in the airways. Moreover, GS143 inhibited antigen-induced differentiation of Th2 cells but not of Th1 cells in vitro. Taken together, these results suggest that I{kappa}B ubiquitination inhibitor may have therapeutic potential against asthma.« less

5 CFR 550.143 - Bases for determining positions for which premium pay under § 550.141 is authorized.

Code of Federal Regulations, 2014 CFR

2014-01-01

... premium pay under § 550.141 is authorized. 550.143 Section 550.143 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Regularly Scheduled Standby Duty Pay § 550.143 Bases for determining positions for which premium pay under § 550.141 is...

5 CFR 550.143 - Bases for determining positions for which premium pay under § 550.141 is authorized.

Code of Federal Regulations, 2012 CFR

2012-01-01

... premium pay under § 550.141 is authorized. 550.143 Section 550.143 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Regularly Scheduled Standby Duty Pay § 550.143 Bases for determining positions for which premium pay under § 550.141 is...

5 CFR 550.143 - Bases for determining positions for which premium pay under § 550.141 is authorized.

Code of Federal Regulations, 2013 CFR

2013-01-01

... premium pay under § 550.141 is authorized. 550.143 Section 550.143 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Regularly Scheduled Standby Duty Pay § 550.143 Bases for determining positions for which premium pay under § 550.141 is...

Boston & Maine Railroad, Berlin Branch Bridge #143.06, Spanning Snyder ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Boston & Maine Railroad, Berlin Branch Bridge #143.06, Spanning Snyder Brook at former Boston & Maine Railroad (now Presidential Range Rail Trail), just south of U.S. Route 2, Randolph, Coos County, NH

P143 proteins from heterologous nucleopolyhedroviruses induce apoptosis in BM-N cells derived from the silkworm Bombyx mori.

PubMed

Hamajima, Rina; Kobayashi, Michihiro; Ikeda, Motoko

2017-04-02

We previously demonstrated that ribosomal RNA (rRNA) of Bombyx mori BM-N cells is rapidly degraded upon infection with heterologous nucleopolyhedroviruses (NPVs), including Autographa californica multiple NPV (AcMNPV), Hyphantria cunea MNPV, Spodoptera exigua MNPV and S. litura MNPV, and that this response is triggered by viral P143 proteins. The transient expression of P143 proteins from heterologous NPVs was also shown to induce apoptosis and caspase-3-like protease activation in BM-N cells. In the present study, we conducted a transient expression assay using BM-N cells expressing mutant AcMNPV P143 (Ac-P143) proteins and demonstrated that five amino acid residues cooperatively participate in Ac-P143 protein-triggered apoptosis of BM-N cells. Notably, these five residues were previously shown to be required for triggering rRNA degradation in BM-N cells. As rRNA degradation in BM-N cells does not result from apoptosis, the present results suggest that Ac-P143-triggered rRNA degradation is the upstream signal for apoptosis induction in BM-N cells. We further showed that P143 protein-triggered apoptosis does not occur in S. frugiperda Sf9 or Lymantria dispar Ld652Y cells, indicating that apoptosis induction by heterologous P143 proteins is a BM-N cell-specific response. In addition, the observed induction of apoptosis in BM-N cells was found to be mediated by activation of the initiator caspase Bm-Dronc. Taken together, these results suggest that BM-N cells evolved a unique antiviral system that recognizes heterologous NPV P143 proteins to induce rRNA degradation and caspase-dependent apoptosis. Copyright © 2017 Elsevier B.V. All rights reserved.

Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism

PubMed Central

De Filippo, Elisabetta; Manga, Prashiela; Schiedel, Anke C.

2017-01-01

Purpose GPR143 regulates melanosome biogenesis and organelle size in pigment cells. The mechanisms underlying receptor function remain unclear. G protein–coupled receptors (GPCRs) are excellent pharmacologic targets; thus, we developed and applied a screening approach to identify potential GPR143 ligands and chemical modulators. Methods GPR143 interacts with β-arrestin; we therefore established a β-arrestin recruitment assay to screen for compounds that modulate activity. Because GPR143 is localized intracellularly, screening with the wild-type receptor would be restricted to agents absorbed by the cell. For the screen we used a mutant receptor, which shows similar basal activity as the wild type but traffics to the plasma membrane. We tested two compound libraries and investigated validated hits for their effects on melanocyte pigmentation. Results GPR143, which showed high constitutive activity in the β-arrestin assay, was inhibited by several compounds. The three validated inhibitors (pimozide, niclosamide, and ethacridine lactate) were assessed for impact on melanocytes. Pigmentation and expression of tyrosinase, a key melanogenic enzyme, were reduced by all compounds. Because GPR143 appears to be constitutively active, these compounds may turn off its activity. Conclusions X-linked ocular albinism type I, characterized by developmental eye defects, results from GPR143 mutations. Identifying pharmacologic agents that modulate GPR143 activity will contribute significantly to our understanding of its function and provide novel tools with which to study GPCRs in melanocytes and retinal pigment epithelium. Pimozide, one of three GPR143 inhibitors identified in this study, maybe be a good lead structure for development of more potent compounds and provide a platform for design of novel therapeutic agents. PMID:28632878

13 CFR 143.20 - Standards for financial management systems.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Requirements Financial Administration § 143.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees... subgrant award documents, etc. (7) Cash management. Procedures for minimizing the time elapsing between the...

13 CFR 143.20 - Standards for financial management systems.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Requirements Financial Administration § 143.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees... subgrant award documents, etc. (7) Cash management. Procedures for minimizing the time elapsing between the...

13 CFR 143.20 - Standards for financial management systems.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Requirements Financial Administration § 143.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees... subgrant award documents, etc. (7) Cash management. Procedures for minimizing the time elapsing between the...

13 CFR 143.20 - Standards for financial management systems.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Requirements Financial Administration § 143.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees... subgrant award documents, etc. (7) Cash management. Procedures for minimizing the time elapsing between the...

19 CFR 143.6 - Failure to maintain performance standards.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Failure to maintain performance standards. 143.6... maintain performance standards. ABI participants must adhere to the performance requirements and... maximum of 90 days, if the participant's performance remains below standard, but, except for immediate...

Models for the Immediate Environment of Ions in Aqueous Solutions of Neodymium Chloride

NASA Astrophysics Data System (ADS)

Smirnov, P. R.; Grechin, O. V.

2018-01-01

Radial distribution functions of neodymium chloride aqueous solutions in a wide range of concentrations under ambient conditions are calculated from experimental data obtained earlier via X-ray diffraction analysis. Different models of the structural organization of the system are developed. The optimum versions are determined by calculating theoretical functions for each model and comparing their fit to the experimental functions. Such quantitative characteristics of the immediate environment of Nd3+ and Cl- ions as coordination numbers, interparticle distances, and varieties of ion pairs are determined. It is shown that the average number of water molecules in the first coordination sphere of the cation falls from 9 to 6.2 as the concentration rises. The structure of the systems over the whole range of concentrations is determined by ion associates of the noncontact type.

Neodymium:YAG laser cutting of intraocular lens haptics in vitro and in vivo.

PubMed

Feder, J M; Rosenberg, M A; Farber, M D

1989-09-01

Various complications following intraocular lens (IOL) surgery result in explantation of the lenses. Haptic fibrosis may necessitate cutting the IOL haptics prior to removal. In this study we used the neodymium: YAG (Nd:YAG) laser to cut polypropylene and poly(methyl methacrylate) (PMMA) haptics in vitro and in rabbit eyes. In vitro we were able to cut 100% of both haptic types successfully (28 PMMA and 30 polypropylene haptics). In rabbit eyes we were able to cut 50% of the PMMA haptics and 43% of the polypropylene haptics. Poly(methyl methacrylate) haptics were easier to cut in vitro and in vivo than polypropylene haptics, requiring fewer shots for transection. Complications of Nd:YAG laser use frequently interfered with haptic transections in rabbit eyes. Haptic transection may be more easily accomplished in human eyes.

A human thyroid cancer cell line, DH-14-3, newly established from poorly differentiated thyroid carcinoma.

PubMed

Teshima, Jin; Doi, Hideyuki; Fujimori, Keisei; Watanabe, Michio; Nakajima, Noriaki; Nakano, Tomoyuki; Takahashi, Yoshio; Ohuchi, Noriaki; Satomi, Susumu

2013-06-01

Poorly differentiated thyroid carcinoma (PDTC) is a newly recognized histological type of malignant thyroid tumor, accounting for about 2 - 13% of all thyroid carcinomas. PDTC is considered as a morphologically and biologically intermediate stage between well-differentiated thyroid carcinoma and anaplastic thyroid carcinoma. PDTC preferentially manifests bone metastases. We here established a cell line from a resected tumor specimen from a 70-year-old male patient with PDTC who presented with multiple bone metastases. This new thyroid tumor cell line was designated as DH-14-3 and was subsequently grown in culture for several years. DH-14-3 cells express thyroglobulin in the cytoplasm and thyroid transcription factor-1 in the nuclei, both proteins of which are specific markers for the thyroid gland. Importantly, triiodothyronine (T3) was detected in the cultured medium of DH-14-3 cells, in which, however, thyroxine (T4) was undetectable. Moreover, DH-14-3 cells secreted interleukin-8, transforming growth factor-β1, vascular endothelial growth factor, matrix metalloproteinase-1 and parathyroid hormone-related protein, all of which may be responsible for the aggressiveness or bone metastasis of PDTC. Thus, the production of these proteins may reflect the metastatic potential of this cell line. DH-14-3 cells also express CXC chemokine receptor-4 and epidermal growth factor receptor, and carry a missense mutation in the p53 tumor suppressor gene. In fact, transplantation of DH-14-3 cells into the back of nude mice resulted in the formation of tumors, thereby confirming the capability of tumorigenesis. DH-14-3 cells may be useful for investigating the biological features of PDTC and will contribute to the therapeutic study of thyroid cancer.

Evaluating United States and world consumption of neodymium, dysprosium, terbium, and praseodymium in final products

NASA Astrophysics Data System (ADS)

Hart, Matthew

This paper develops scenarios of future rare-earth-magnet metal (neodymium, dysprosium, terbium, and praseodymium) consumption in the permanent magnets used in wind turbines and hybrid electric vehicles. The scenarios start with naive base-case scenarios for growth in wind-turbine and hybrid-electric-vehicle sales over the period 2011 to 2020, using historical data for each good. These naive scenarios assume that future growth follows time trends in historical data and does not depend on any exogenous variable. Specifically, growth of each technological market follows historical time trends, and the amount of rare earths used per unit of technology remains fixed. The chosen reference year is 2010. Implied consumptions of the rare earth magnet metals are calculated from these scenarios. Assumptions are made for the material composition of permanent magnets, the market share of permanent-magnet wind turbines and vehicles, and magnet weight per unit of technology. Different scenarios estimate how changes in factors like the material composition of magnets, growth of the economy, and the price of a substitute could affect future consumption. Each scenario presents a different method for reducing rare earth consumption and could be interpreted as potential policy choices. In 2010, the consumption (metric tons, rare-earth-oxide equivalent) of each rare-earth-magnet metal was as follows. Total neodymium consumption in the world for both technologies was 995 tons; dysprosium consumption was 133 tons; terbium consumption was 50 tons; praseodymium consumption was zero tons. The base scenario for wind turbines shows there could be strong, exponential growth in the global wind turbine market. New U.S. sales of hybrid vehicles would decline (in line with the current economic recession) while non-U.S. sales increase through 2020. There would be an overall increase in the total amount of magnetic rare earths consumed in the world. Total consumption of each rare earth in the short

143. MOBILE HIGH PRESSURE NITROGEN CART STORED IN CONTROL ROOM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

143. MOBILE HIGH PRESSURE NITROGEN CART STORED IN CONTROL ROOM (214), LSB (BLDG. 751) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

17 CFR 143.8 - Inflation-adjusted civil monetary penalties.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Inflation-adjusted civil... JURISDICTION General Provisions § 143.8 Inflation-adjusted civil monetary penalties. (a) Unless otherwise amended by an act of Congress, the inflation-adjusted maximum civil monetary penalty for each violation of...

TGFβ Triggers miR-143/145 Transfer From Smooth Muscle Cells to Endothelial Cells, Thereby Modulating Vessel Stabilization.

PubMed

Climent, Montserrat; Quintavalle, Manuela; Miragoli, Michele; Chen, Ju; Condorelli, Gianluigi; Elia, Leonardo

2015-05-22

The miR-143/145 cluster is highly expressed in smooth muscle cells (SMCs), where it regulates phenotypic switch and vascular homeostasis. Whether it plays a role in neighboring endothelial cells (ECs) is still unknown. To determine whether SMCs control EC functions through passage of miR-143 and miR-145. We used cocultures of SMCs and ECs under different conditions, as well as intact vessels to assess the transfer of miR-143 and miR-145 from one cell type to another. Imaging of cocultured cells transduced with fluorescent miRNAs suggested that miRNA transfer involves membrane protrusions known as tunneling nanotubes. Furthermore, we show that miRNA passage is modulated by the transforming growth factor (TGF) β pathway because both a specific transforming growth factor-β (TGFβ) inhibitor (SB431542) and an shRNA against TGFβRII suppressed the passage of miR-143/145 from SMCs to ECs. Moreover, miR-143 and miR-145 modulated angiogenesis by reducing the proliferation index of ECs and their capacity to form vessel-like structures when cultured on matrigel. We also identified hexokinase II (HKII) and integrin β 8 (ITGβ8)-2 genes essential for the angiogenic potential of ECs-as targets of miR-143 and miR-145, respectively. The inhibition of these genes modulated EC phenotype, similarly to miR-143 and miR-145 overexpression in ECs. These findings were confirmed by ex vivo and in vivo approaches, in which it was shown that TGFβ and vessel stress, respectively, triggered miR-143/145 transfer from SMCs to ECs. Our results demonstrate that miR-143 and miR-145 act as communication molecules between SMCs and ECs to modulate the angiogenic and vessel stabilization properties of ECs. © 2015 American Heart Association, Inc.

143. GENERAL DYNAMICS SPACE SYSTEMS DIVISION SCHEDULE BOARD IN LUNCH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

143. GENERAL DYNAMICS SPACE SYSTEMS DIVISION SCHEDULE BOARD IN LUNCH ROOM (120), LSB (BLDG. 770) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Elevation of Proenkephalin 143-183 in Cerebrospinal Fluid in Moyamoya Disease.

PubMed

Yokoyama, Kinya; Maruwaka, Mikio; Yoshikawa, Kazuhiro; Araki, Yoshio; Okamoto, Sho; Sumitomo, Masaki; Kawamura, Akino; Sakamoto, Yusuke; Shimizu, Kenzo; Izumi, Takashi; Wakabayashi, Toshihiko

2018-01-01

In moyamoya disease (MMD), the causes of differences in clinical features between children and adults and of the dramatic temporal changes in moyamoya vessels are poorly understood. We previously discovered elevated levels of m/z 4588 and m/z 4473 peptides in cerebrospinal fluid (CSF) in patients with MMD. This study examined the amino acid sequences of these peptides and quantified in specimens. The m/z 4588 and m/z 4473 peptides in CSF from patients with MMD were purified and concentrated by high-performance liquid chromatography and ultrafiltration. Liquid chromatography coupled with tandem mass spectrometry analysis was performed to identify the amino acid sequences of these peptides. We quantified these peptides in samples using sandwich enzyme-linked immunosorbent assay, and concentrations in CSF were compared between MMD (n = 40, 19 male; median age, 37 years) and non-MMD intracranial disease (n = 40, 19 male; median age, 39 years) as controls. These peptides were identified as proenkephalin 143-183 (PENK 143-183). The concentration of PENK 143-183 was significantly greater in patients with MMD (median, 8,270 pmol/L) than control patients (median, 3,760 pmol/L; P < 0.001) and decreased in an age-dependent manner in MMD (r = -0.57; P < 0.001). The area under the receiver operating characteristic curve in children (age <18 years) was 0.885 (95% confidence interval 0.741-1). The correlation between proenkephalin concentration and temporal changes in moyamoya vessels was suggested. Proenkephalin 143-183 in CSF may offer a helpful diagnostic biomarker in pediatric MMD. The effect of enkephalin peptides through opioid growth factor receptor or delta opioid receptor might be associated with the pathophysiology of MMD. Copyright © 2017 Elsevier Inc. All rights reserved.

The characterisation and application of a pulsed neodymium YAG laser DGV system to a time-varying high-speed flow

NASA Astrophysics Data System (ADS)

Thorpe, S. J.; Quinlan, N.; Ainsworth, R. W.

2000-10-01

Doppler Global Velocimetry (DGV) is a whole-field measurement technique which has attracted significant interest from the fluid-flow research community since its introduction in 1991. Practical implementations of the methodology have focused on two principal laser light sources: the argon ion laser, applied to steady state or slowly varying flows; and the pulsed neodymium YAG laser for the measurement of instantaneous velocity fields. However, the emphasis in the published literature has been very much on research using the argon laser. This paper reports the application of a Q-switched, injection-seeded neodymium YAG laser to the proven Oxford DGV system, and the use of this combination in a short duration unsteady high-speed flow. The pertinent characteristics of the apparatus are described, and the impact of these on the integrity of the resulting velocity measurements is presented. Adaptations to the commercial laser system that make it suitable for application to the measurement of transient high-speed flows are described. Finally, the application of this system to a short duration unsteady flow is described. This application is based on the flow found in a new type of transdermal drug delivery device, where particles of the drug material are projected at high speed through the skin. Whole-field velocities are recorded, and values as high as 800 m/ s are evident.

Extraction of seawater-derived neodymium from different phases of deep sea sediments by selective leaching

NASA Astrophysics Data System (ADS)

Blaser, P.; Lippold, J. A.; Frank, N.; Gutjahr, M.; Böhm, E.

2014-12-01

In order to deduce reliable information about the interaction of the oceans with the climate system as a whole in the past, the reconstruction of water mass circulation is crucial. The analysis of seawater-derived neodymium isotopes (143Nd/144Nd, expressed as ɛNd) in marine sediments provides a unique proxy for deep water provenance in particular in the Atlantic [1]. The ɛNd signature and thus the mixing proportion of the local bottom water masses is archived in authigenic phases in the sediment. Obtaining seawater ɛNd from authigenic accretions bound to foraminiferal tests has lately become the preferred since most reliable method [2]. Attempts have also been made to extract the Nd-rich authigenic metal fraction by leaching it off the bulk sediment and thereby use this proxy with less effort, in the highest possible resolution and in sediments where foraminifera are not sufficiently present. However, often other sedimentary components are also leached in the process and contaminate the extracted Nd [3,4]. In this project several core-top and older sediments across the Atlantic have been leached in ten consecutive steps with either dilute buffered acetic acid or an acid-reductive solution. The leachates were analysed on their elemental and Nd isotope compositions, as well as rare earth element (REE) distributions. By graduating the total leaching procedure into smaller stages the results display which processes take place in the course of sediment leaching in the laboratory and which components of the sediment are most reactive. Thus, they help to better evaluate the quality of sediment leaches for ɛNd analysis. Clearly, organic calcite acts as a fast reacting buffer and at the point where its amount is sufficiently reduced the leaching of other components commences and the Nd concentration peaks. Corruption of the extracted ɛNd signal by non-authigenic sources in many cases occured early in the leaching sequence, indicating that only very cautious leaching

Laboratory and clinical experience with neodymium:YAG laser prostatectomy

NASA Astrophysics Data System (ADS)

Kabalin, John N.

1996-05-01

Since 1991, we have undertaken extensive laboratory and clinical studies of the Neodymium:YAG (Nd:YAG) laser for surgical treatment of bladder outlet obstruction due to prostatic enlargement or benign prostatic hyperplasia (BPH). Side-firing optical fibers which emit a divergent, relatively low energy density Nd:YAG laser beam produce coagulation necrosis of obstructing periurethral prostate tissue, followed by gradual dissolution and slough in the urinary stream. Laser-tissue interactions and Nd:YAG laser dosimetry for prostatectomy have been studied in canine and human prostate model systems, enhancing clinical application. Ongoing studies examine comparative Nd:YAG laser dosimetry for various beam configurations produced by available side-firing optical fibers and continue to refine operative technique. We have documented clinical outcomes of Nd:YAG laser prostatectomy in 230 consecutive patients treated with the UrolaseTM side-firing optical fiber. Nd:YAG laser coagulation the prostate produces a remarkably low acute morbidity profile, with no significant bleeding or fluid absorption. No postoperative incontinence has been produced. Serial assessments of voiding outcomes over more than 3 years of followup show objective and symptomatic improvement following Nd:YAG laser prostatectomy which is comparable to older but more morbid electrosurgical approaches. Nd:YAG laser prostatectomy is a safe, efficacious, durable and cost-effective treatment for BPH.

40 CFR 429.143 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... achievable (BAT). 429.143 Section 429.143 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... reduction attainable by the application of the best available technology economically achievable (BAT... attainable by the application of the best available technology economically achievable (BAT): There shall be...

40 CFR 440.143 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2013 CFR

2013-07-01

... achievable (BAT). 440.143 Section 440.143 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... attainable by the application of the best available technology economically achievable (BAT). Except as... of the best available technology economically achievable (BAT). (a) The volume of process wastewater...

40 CFR 429.143 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2014 CFR

2014-07-01

... achievable (BAT). 429.143 Section 429.143 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... reduction attainable by the application of the best available technology economically achievable (BAT... attainable by the application of the best available technology economically achievable (BAT): There shall be...

50 CFR 648.143 - Black sea bass Accountability Measures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Black sea bass Accountability Measures... Management Measures for the Black Sea Bass Fishery § 648.143 Black sea bass Accountability Measures. (a... based on dealer reports, state data, and other available information. All black sea bass landed for sale...

50 CFR 648.143 - Black sea bass Accountability Measures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Black sea bass Accountability Measures... Management Measures for the Black Sea Bass Fishery § 648.143 Black sea bass Accountability Measures. (a... based on dealer reports, state data, and other available information. All black sea bass landed for sale...

50 CFR 648.143 - Black sea bass Accountability Measures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Black sea bass Accountability Measures... Management Measures for the Black Sea Bass Fishery § 648.143 Black sea bass Accountability Measures. (a... based on dealer reports, state data, and other available information. All black sea bass landed for sale...

33 CFR 143.201 - Existing MODUs exempted from new design requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Mobile Offshore Drilling Units § 143.201 Existing MODUs exempted from new design requirements. Any mobile offshore drilling...

MiR-143 enhances the antitumor activity of shikonin by targeting BAG3 expression in human glioblastoma stem cells.

PubMed

Liu, Jing; Qu, Cheng-Bin; Xue, Yi-Xue; Li, Zhen; Wang, Ping; Liu, Yun-hui

Therapeutic applications of microRNAs (miRNAs) in chemotherapy were confirmed to be valuable, but there is rare to identify their specific roles and functions in shikonin treatment toward tumors. Here, for the first time, we reported that miR-143 played a critical role in the antitumor activity of shikonin in glioblastoma stem cells (GSCs). The results showed that the expression of miR-143 was downregulated in shikonin treated GSCs within 24 h. MiR-143 overexpression significantly enhanced the inhibitory effect of shikonin toward GSCs on cell viability. Besides, miR-143 overexpression caused a significant increase in the apoptotic fraction and made apoptosis occur earlier. Further investigation identified that BAG3, an apoptotic regulator, was a functional target of miR-143 in shikonin treated GSCs. The expression of BAG3 was upregulated in shikonin treated GSCs within 24 h. MiR-143 overexpression significantly reversed the high expression of BAG3 in shikonin treated GSCs. Moreover, it was confirmed that the enhanced cytotoxicity of shikonin by miR-143 overexpression was reversed by BAG3 overexpression both in vitro and in vivo, suggesting that the enhanced tumor suppressive effects by miR-143 overexpression was at least partly through the regulation of BAG3. Taken together, for the first time, our results demonstrate that miR-143 could enhance the antitumor activity of shikonin toward GSCs through reducing BAG3 expression, which may provide a novel therapeutic strategy for enhancing the treatment efficacy of shikonin toward GSCs. Copyright © 2015 Elsevier Inc. All rights reserved.

Neodymium glass laser with a phase conjugate mirror producing 220 J pulses at 0.02 Hz repetition rate.

PubMed

Kuzmin, A A; Khazanov, E A; Kulagin, O V; Shaykin, A A

2014-08-25

For pumping multipetawatt Ti:sapphire laser facilities we developed a compact repetitively pulsed laser based on neodymium phosphate glass with pulse energy of 220 J, pulse repetition rate of 0.02 Hz, beam diameter of 43 mm, aperture fill factor of 0.8, and FWHM pulse duration of 30 ns. The phase distortions of laser radiation were compensated by optical phase conjugation via stimulated Brillouin scattering. The depolarization was reduced to 0.4% using linear compensation methods. The beam quality was 2.5 x diffraction limit (150 µrad).

Gadolinium and didymium (praseodymium/neodymium) cations as capture agents in lightmicroscopical histochemistry of acid and alkaline phosphatase.

PubMed

Halbhuber, K J; Zimmermann, N

1987-01-01

In previous papers, cerium and lanthanum based methods for light-microscopical detection of acid and alkaline phosphatase activity were proposed. In this paper, the usefulness of other lanthanide cations such as gadolinium and praseodymium/neodymium cations as capture agents in phosphatase histochemistry is tested. It is evident that phosphate ions were sufficiently trapped by these cations. According to the lead and silver multistep procedures earlier described it is possible to visualize alkaline phosphatase activity in the brush borders of the intestine or kidney as well as acid phosphatase activity in the lysosomes. These methods can be recommended.

1. Intersection of US Route 4 and NH Route 143, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Intersection of US Route 4 and NH Route 143, showing farmhouse on left, barn at right. Looking east. - Batchelder-Edgerly Farmstead, Barn, U.S. Route 4, southwest side, southeast corner of New Hampshire Route 43, Northwood, Rockingham County, NH

A new solid-state, frequency-doubled neodymium-YAG photocoagulation system.

PubMed

Jalkh, A E; Pflibsen, K; Pomerantzeff, O; Trempe, C L; Schepens, C L

1988-06-01

We have developed a solid-state laser system that produces a continuous green monochromatic laser beam of 532 nm by doubling the frequency of a neodymium-YAG laser wavelength of 1064 nm with a potassium-titamyl-phosphate crystal. Photocoagulation burns of equal size and intensity were placed in two rabbit eyes with the solid-state laser system and the regular green argon laser system, respectively, using the same slit-lamp mode of delivery. Histologic findings of lesion sections revealed no important differences between the two systems. In theory, the longer wavelength of the solid-state laser offers the advantages of less scattering in ocular media, higher absorption by oxyhemoglobin, and less absorption by macular xanthophyll than the 514-nm wavelength of the regular green argon laser. The solid-state laser has impressive technical advantages: it contains no argon-ion gas tube that wears out and is expensive to replace; it is much more power efficient, and thus considerably smaller and compact; it is sturdier and easily movable; it does not require external cooling; it uses a 220-V monophasic alternating current; and it requires little maintenance.

Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11

PubMed Central

Ngondo-Mbongo, Richard Patryk; Myslinski, Evelyne; Aster, Jon C.; Carbon, Philippe

2013-01-01

ZNF143 is a zinc-finger protein involved in the transcriptional regulation of both coding and non-coding genes from polymerase II and III promoters. Our study deciphers the genome-wide regulatory role of ZNF143 in relation with the two previously unrelated transcription factors Notch1/ICN1 and thanatos-associated protein 11 (THAP11) in several human and murine cells. We show that two distinct motifs, SBS1 and SBS2, are associated to ZNF143-binding events in promoters of >3000 genes. Without co-occupation, these sites are also bound by Notch1/ICN1 in T-lymphoblastic leukaemia cells as well as by THAP11, a factor involved in self-renewal of embryonic stem cells. We present evidence that ICN1 binding overlaps with ZNF143 binding events at the SBS1 and SBS2 motifs, whereas the overlap occurs only at SBS2 for THAP11. We demonstrate that the three factors modulate expression of common target genes through the mutually exclusive occupation of overlapping binding sites. The model we propose predicts that the binding competition between the three factors controls biological processes such as rapid cell growth of both neoplastic and stem cells. Overall, our study establishes a novel relationship between ZNF143, THAP11 and ICN1 and reveals important insights into ZNF143-mediated gene regulation. PMID:23408857

40 CFR 415.143 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... economically achievable (BAT). 415.143 Section 415.143 Protection of Environment ENVIRONMENTAL PROTECTION... economically achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source... (BAT): There shall be no discharge of process wastewater pollutants to navigable waters. ...

40 CFR 415.143 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... economically achievable (BAT). 415.143 Section 415.143 Protection of Environment ENVIRONMENTAL PROTECTION... economically achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source... (BAT): There shall be no discharge of process wastewater pollutants to navigable waters. ...

40 CFR 415.143 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... economically achievable (BAT). 415.143 Section 415.143 Protection of Environment ENVIRONMENTAL PROTECTION... economically achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source... (BAT): There shall be no discharge of process wastewater pollutants to navigable waters. ...

33 CFR 143.205 - Requirements for U.S. and undocumented MODUs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Mobile Offshore Drilling Units § 143.205 Requirements for U.S. and undocumented MODUs. Each mobile offshore drilling unit that is...

Neodymium doped fluoroindogallate glasses as highly-sensitive luminescent non-contact thermometers

NASA Astrophysics Data System (ADS)

Nunes, Luiz A. O.; Souza, Adelmo S.; Carlos, Luís D.; Malta, Oscar L.

2017-01-01

Trivalent neodymium (Nd3+) can be used as high performance temperature luminescent ion sensor, namely in the near infrared spectral region. The disadvantage presented in the use of this ion is that transitions from thermally coupled levels show very different emission intensities. In order to solve this critical problem we propose to use Nd3+-doped fluoroindogallate glasses with low phonon cutoff energy (500 cm-1) as the active medium. By using a dopant concentration that minimizes losses due to cross relaxation processes and detecting the emissions of the thermally coupled levels with a R928 photomultiplier, without correction response for the wavelength dependence of the intensity, we have succeeded in getting the highest relative thermal sensitivities so far observed, 2.5%ṡK-1 and 7.4%ṡK-1, for the 4F5/2 → 4I9/2/4F3/2 → 4I9/2 and 4F7/2 → 4I9/2/4F3/2 → 4I9/2 intensity ratios, respectively at 288 K.

ME-143 Is Superior to Genistein in Suppression of WNT Signaling in Colon Cancer Cells.

PubMed

Pintova, Sofya; Planutis, Kestutis; Planutiene, Marina; Holcombe, Randall F

2017-04-01

This study tested the effect of the soy isoflavones genistein and ME-143, and two chemotherapeutic agents, 5-fluorouracil (5FU) and oxaliplatin, on WNT signaling. Colon cancer cell lines RKO (hereditary nonpolyposis colorectal cancer type) and DLD1 (most common colorectal cancer type driven by a mutation in WNT pathway) were utilized. WNT throughput was measured using a β-catenin-responsive SuperTopFlash luciferase assay. A stabilized β-catenin construct was employed to test β-catenin involvement in the mechanism of drug activity. ME-143 was a more than 10-fold potent inhibitor of DLD1 proliferation than genistein at 3.125 μM. Genistein alone did not inhibit WNT signaling in either cell line. In RKO cells, oxaliplatin and its combination with 5FU significantly inhibited WNT throughput. Neither 5FU, oxaliplatin nor their combination inhibited WNT signaling in DLD1 cells. In both the RKO and DLD1 cell lines, ME-143 significantly reduced WNT throughput by 65-75%. The introduction of stabilized β-catenin attenuated the ME-143-dependent inhibition of the WNT/β-catenin pathway. ME-143 alone and in combination with 5FU and oxaliplatin effectively inhibits the WNT/β-catenin pathway in colorectal cancer cells of diverse genetic background. β-Catenin is directly involved in the mechanism of inhibition, and clinical studies are warranted. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

77 FR 45575 - Foreign-Trade Zone 143-West Sacramento, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... Sacramento, CA Application for Extended Production Authority; Subzone 143D, Grafil Inc. (Carbon Fiber... and distribution of carbon fiber using polyacrylonitrile (PAN) precursor. Grafil's subzone and... to choose the duty rate during customs entry procedures that apply to carbon fiber (duty free) for...

Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity

PubMed Central

Zhang, Yuan; Shen, Kai; Bai, Ying; Lv, Xuan; Huang, Rongrong; Zhang, Wei; Chao, Jie; Nguyen, Lan K.; Hua, Jun; Gan, Guangming; Hu, Gang; Yao, Honghong

2016-01-01

ABSTRACT BBC3 (BCL2 binding component 3) is a known apoptosis inducer; however, its role in microglial survival remains poorly understood. In addition to the classical transcription factor TRP53, Mir143 is involved in BBC3 expression at the post-transcriptional level. Here, we identify unique roles of Mir143-BBC3 in mediating microglial survival via the regulation of the interplay between apoptosis and autophagy. Autophagy inhibition accelerated methamphetamine-induced apoptosis, whereas autophagy induction attenuated the decrease in microglial survival. Moreover, anti-Mir143-dependent BBC3 upregulation reversed the methamphetamine-induced decrease in microglial survival via the regulation of apoptosis and autophagy. The in vivo relevance of these findings was confirmed in mouse models, which demonstrated that the microinjection of anti-Mir143 into the hippocampus ameliorated the methamphetamine-induced decrease in microglia as well as that observed in heterozygous Mir143+/− mice. These findings provide new insight regarding the specific contributions of Mir143-BBC3 to microglial survival in the context of drug abuse. PMID:27464000

Lithotripsy of gallstones by means of a quality-switched giant-pulse neodymium:yttrium-aluminum-garnet laser. Basic in vitro studies using a highly flexible fiber system.

PubMed

Hochberger, J; Gruber, E; Wirtz, P; Dürr, U; Kolb, A; Zanger, U; Hahn, E G; Ell, C

1991-11-01

The quality-switched neodymium:yttrium-aluminum-garnet laser represents a new instrument for athermal fragmentation of gallstones by transformation of optical energy into mechanical energy in the form of shock waves via local plasma formation. A highly flexible 300-micron fiber transmission system was used in basic investigations to determine the influence of varying pulse repetition rates (5-30 Hz) and pulse energies (15 and 20 mJ) on shock wave intensity and stone fragmentation in vitro for 105 biliary calculi of known size and chemical composition. After performance of 1200 shock wave pressure measurements using polyvinylidenefluoride hydrophones, stone fragmentation was analyzed by determination of fragment removal rates (volume of fragments removed per fragmentation time), ablation rates (mean volume removed per laser pulse), and median fragment sizes for each laser setting. With the quality-switched neodymium:yttrium-aluminum-garnet laser system, all concrements could be reliably disintegrated into small fragments (median diameter, 0.7-1.7 mm). Compared with pure cholesterol stones, a significantly higher fragment removal rate was achieved in cholesterol stones containing 30% calcium phosphate (P = 0.039), in cholesterol stones containing 20% pigment (P = 0.015), and in pure pigment stones (P = 0.007). Fragment removal rates, local shock wave pressures, and median grain sizes were significantly higher at a pulse energy of 20 mJ than with 15 mJ. Shock wave pressures showed a distinct dependence on pulse repetition rates at 20 mJ, yet not at 15 mJ. Because there is no evident hazard of thermal damage to tissue using the quality-switched neodymium:yttrium-aluminum-garnet laser, it appears to be a promising device for nonsurgical biliary stone therapy.

31 CFR 363.143 - How do I purchase a security using the redemption proceeds of my zero-percent certificate of...

Code of Federal Regulations, 2012 CFR

2012-07-01

... redemption proceeds of my zero-percent certificate of indebtedness? 363.143 Section 363.143 Money and Finance... BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Zero-Percent Certificate of Indebtedness Zero-Percent Certificate of Indebtedness § 363.143 How do I purchase a security...

31 CFR 363.143 - How do I purchase a security using the redemption proceeds of my zero-percent certificate of...

Code of Federal Regulations, 2011 CFR

2011-07-01

... redemption proceeds of my zero-percent certificate of indebtedness? 363.143 Section 363.143 Money and Finance... BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Zero-Percent Certificate of Indebtedness Zero-Percent Certificate of Indebtedness § 363.143 How do I purchase a security...

31 CFR 363.143 - How do I purchase a security using the redemption proceeds of my zero-percent certificate of...

Code of Federal Regulations, 2013 CFR

2013-07-01

... redemption proceeds of my zero-percent certificate of indebtedness? 363.143 Section 363.143 Money and Finance... BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Zero-Percent Certificate of Indebtedness Zero-Percent Certificate of Indebtedness § 363.143 How do I purchase a security...

Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells.

PubMed

Gomes, Sofia E; Pereira, Diane M; Roma-Rodrigues, Catarina; Fernandes, Alexandra R; Borralho, Pedro M; Rodrigues, Cecília M P

2018-01-01

MicroRNAs (miRNAs) regulate a wide variety of biological processes, including tumourigenesis. Altered miRNA expression is associated with deregulation of signalling pathways, which in turn cause abnormal cell growth and de-differentiation, contributing to cancer. miR-143 and miR-145 are anti-tumourigenic and influence the sensitivity of tumour cells to chemotherapy and targeted therapy. Comparative proteomic analysis was performed in HCT116 human colon cancer cells stably transduced with miR-143 or miR-145. Immunoblotting analysis validated the proteomic data in stable and transient miRNA overexpression conditions in human colon cancer cells. We show that approximately 100 proteins are differentially expressed in HCT116 human colon cancer cells stably transduced with miR-143 or miR-145 compared to Empty control cells. Further, Gene Ontology and pathway enrichment analysis indicated that proteins involved in specific cell signalling pathways such as cell death, response to oxidative stress, and protein folding might be modulated by these miRNAs. In particular, antioxidant enzyme superoxide dismutase 1 (SOD1) was downregulated by stable expression of either miR-143 or miR-145. Further, SOD1 gain-of-function experiments rescued cells from miR-143-induced oxidative stress. Moreover, miR-143 overexpression increased oxaliplatin-induced apoptosis associated with reactive oxygen species generation, which was abrogated by genetic and pharmacological inhibition of oxidative stress. Overall, miR-143 might circumvent resistance of colon cancer cells to oxaliplatin via increased oxidative stress in HCT116 human colon cancer cells.

Intracavity frequency doubling of a continuous-wave, diode-laser-pumped neodymium lanthanum scandium borate laser.

PubMed

Meyn, J P; Huber, G

1994-09-15

Neodymium-doped lanthanum scandium borate [Nd:LaSc(3)(BO(3))(4)] is a new material for efficient and compact diode-pumped solid-state lasers. A simple plane-plane 3-mm-long resonator is formed by a coated Nd(10%):LaSc(3)(BO(3))(4) crystal and a coated potassium titanyl phosphate (KTP) crystal. The second-harmonic output power at 531 nm is 522 mW at 2.05-W incident pump power of the diode laser. The corresponding optical efficiency is 25%, and the conversion efficiency from the fundamental to the second harmonic is 55%. The wellknown chaotic power fluctuations of intracavity frequency-doubled lasers (green problem) are avoided by use of a short KTP crystal, between 0.5 and 2 mm in length.

31 CFR 363.143 - What happens if an ACH payment used to purchase a certificate of indebtedness is later reversed?

Code of Federal Regulations, 2010 CFR

2010-07-01

... processed security transactions, including securities that were purchased as gifts and securities that have... to purchase a certificate of indebtedness is later reversed? 363.143 Section 363.143 Money and... Indebtedness § 363.143 What happens if an ACH payment used to purchase a certificate of indebtedness is later...

31 CFR 363.143 - How do I purchase a security using the redemption proceeds of my zero-percent certificate of...

Code of Federal Regulations, 2014 CFR

2014-07-01

... the redemption proceeds of my zero-percent certificate of indebtedness? 363.143 Section 363.143 Money... Zero-Percent Certificate of Indebtedness Zero-Percent Certificate of Indebtedness § 363.143 How do I purchase a security using the redemption proceeds of my zero-percent certificate of indebtedness? You may...

Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin, Jianfeng; Wang, Dayong; Xiao, Haifeng

Heme oxygenase (HO) is the rate-limiting enzyme in heme metabolism. HO-1 exhibits anti-oxidative and anti-inflammatory function via the actions of its metabolite, respectively. A growing body of evidence demonstrates that HO-1 is implicated in the pathogenesis and progression of several types of cancer. However, whether HO-1 takes part in healthy-premalignant-malignant transformation is still undefined. In this study, we took advantage of transgenic mice which over-expressed HO-1 dominant negative mutant (HO-1 G143H) and observed its susceptibility to DEN-induced hepatocarcinogenesis. Our results indicate that HO-1 G143H mutant accelerates the progression of tumorigenesis and tumor growth. The mechanism is closely related to enhancementmore » of ROS production which induce more hepatocytes death and secretion of inflammatory cytokines, proliferation of surviving hepatocytes. Our result provides the direct evidence that HO-1 plays an important protective role in liver carcinogenesis. Alternatively, we suggest the possible explanation on effect of HO-1 promoter polymorphism which involved in tumorigenesis. - Highlights: • Enhancement of DEN-induced hepatocarcinogenesis in HO-1 G143H Tg mice. • HO-1G143H mutant enhanced DEN-induced ROS production and liver injury. • HO-1G143H mutant aggravated DEN-induced changes of inflammatory factors and cell proliferation.« less

143. VIEW OF PARAPET WALL WITH ONE OF THE LAMP ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

143. VIEW OF PARAPET WALL WITH ONE OF THE LAMP COLUMNS (WITH LAMP REMOVED). PARAPET WALL FLANKS ROAD ACROSS TOP OF DAM. THIS SECTION OF PARAPET WALL IS ON THE SOUTH SIDE OF THE DAM, LOOKING SOUTHWEST (January 1991) - Coolidge Dam, Gila River, Peridot, Gila County, AZ

Anterior capsule relaxing incisions with neodymium:YAG laser for patients at high-risk for anterior capsule contraction.

PubMed

Hayashi, Ken; Yoshida, Motoaki; Hirata, Akira; Hayashi, Hideyuki

2011-01-01

To examine the effect of anterior capsule relaxing incisions created with a neodymium:YAG (Nd:YAG) laser on prevention of anterior capsule contraction after cataract surgery in high-risk patients. Hayashi Eye Hospital, Fukuoka, Japan. Randomized masked clinical trials. Patients at high risk for anterior capsule contraction had anterior capsule relaxing incisions in either eye 3 days postoperatively. The anterior capsule opening was measured using a Scheimpflug videophotography system (EAS-1000) immediately and 1, 3, and 6 months after capsulotomy, and the percentage reduction in area was calculated. The degree of intraocular lens (IOL) decentration and tilt, posterior capsule opacification (PCO), and other complications were also assessed. Of the 84 patients included, 30 had primary angle closure, 28 had pseudoexfoliation, and 26 had diabetic retinopathy. There was no significant difference in the mean opening area between fellow eyes at baseline. In patients with primary angle closure, the area was significantly greater and the percentage reduction in area was significantly less in the capsulotomy group than in the no-capsulotomy group (P≤.0428). In patients with pseudoexfoliation or diabetic retinopathy, the percentage reduction was significantly less in the capsulotomy group than in the no-capsulotomy group (P≤.0493), although there was no significant difference in area. No significant difference was found in IOL decentration or tilt, PCO, or incidence of other complications. Neodymium:YAG laser anterior capsule relaxing incisions in the early period after cataract surgery were effective in preventing anterior capsule contraction in high-risk patients and had no adverse effects. No author has a financial or proprietary interest in any material or method mentioned. Copyright © 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

IDENTIFICATION OF NEODYMIUM IN THE APOGEE H -BAND SPECTRA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hasselquist, Sten; Holtzman, Jon; Chojnowski, Drew

2016-12-10

We present the detection of 10 lines of singly ionized neodymium (Nd ii, Z  = 60) in H -band spectra using observations from the SDSS-III Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. These lines were detected in a metal-poor ([Fe/H] ∼ −1.5), neutron-capture element-enhanced star recently discovered in the APOGEE sample. Using an optical high-resolution spectrum, we derive a Nd abundance for this star using Nd ii lines with precise, laboratory-derived gf values. This optical abundance is used to derive log( gf ) values for the H -band lines. We use these lines to rederive Nd ii abundances for two more metal-rich, s -process enhancedmore » stars observed by APOGEE and find that these lines yield consistent Nd ii abundances, confirming the Nd enhancement of these stars. We explore the region of parameter space in the APOGEE sample over which these lines can be used to measure Nd ii abundances. We find that Nd abundances can be reliably derived for ∼18% of the red giants observed by APOGEE. This will result in ∼50,000 Milky Way stars with Nd ii abundances following the conclusion of APOGEE-2, allowing for studies of neutron-capture element abundance distributions across the entire Milky Way.« less

TGF-β signaling controls FSHR signaling-reduced ovarian granulosa cell apoptosis through the SMAD4/miR-143 axis.

PubMed

Du, Xing; Zhang, Lifan; Li, Xinyu; Pan, Zengxiang; Liu, Honglin; Li, Qifa

2016-11-24

Follicle-stimulating hormone receptor (FSHR) and its intracellular signaling control mammalian follicular development and female infertility. Our previous study showed that FSHR is downregulated during follicular atresia of porcine ovaries. However, its role and regulation in follicular atresia remain unclear. Here, we showed that FSHR knockdown induced porcine granulosa cell (pGC) apoptosis and follicular atresia, and attenuated the levels of intracellular signaling molecules such as PKA, AKT and p-AKT. FSHR was identified as a target of miR-143, a microRNA that was upregulated during porcine follicular atresia. miR-143 enhanced pGC apoptosis by targeting FSHR, and reduced the levels of intracellular signaling molecules. SMAD4, the final molecule in transforming growth factor (TGF)-β signaling, bound to the promoter and induced significant downregulation of miR-143 in vitro and in vivo. Activated TGF-β signaling rescued miR-143-reduced FSHR and intracellular signaling molecules, and miR-143-induced pGC apoptosis. Overall, our findings offer evidence to explain how TGF-β signaling influences and FSHR signaling for regulation of pGC apoptosis and follicular atresia by a specific microRNA, miR-143.

TGF-β signaling controls FSHR signaling-reduced ovarian granulosa cell apoptosis through the SMAD4/miR-143 axis

PubMed Central

Du, Xing; Zhang, Lifan; Li, Xinyu; Pan, Zengxiang; Liu, Honglin; Li, Qifa

2016-01-01

Follicle-stimulating hormone receptor (FSHR) and its intracellular signaling control mammalian follicular development and female infertility. Our previous study showed that FSHR is downregulated during follicular atresia of porcine ovaries. However, its role and regulation in follicular atresia remain unclear. Here, we showed that FSHR knockdown induced porcine granulosa cell (pGC) apoptosis and follicular atresia, and attenuated the levels of intracellular signaling molecules such as PKA, AKT and p-AKT. FSHR was identified as a target of miR-143, a microRNA that was upregulated during porcine follicular atresia. miR-143 enhanced pGC apoptosis by targeting FSHR, and reduced the levels of intracellular signaling molecules. SMAD4, the final molecule in transforming growth factor (TGF)-β signaling, bound to the promoter and induced significant downregulation of miR-143 in vitro and in vivo. Activated TGF-β signaling rescued miR-143-reduced FSHR and intracellular signaling molecules, and miR-143-induced pGC apoptosis. Overall, our findings offer evidence to explain how TGF-β signaling influences and FSHR signaling for regulation of pGC apoptosis and follicular atresia by a specific microRNA, miR-143. PMID:27882941

42 CFR 480.143 - QIO involvement in shared health data systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS ACQUISITION, PROTECTION, AND DISCLOSURE OF QUALITY IMPROVEMENT ORGANIZATION INFORMATION Utilization and Quality Control Quality Improvement Organizations (QIOs) Disclosure of Confidential Information § 480.143 QIO involvement in shared health data...

42 CFR 480.143 - QIO involvement in shared health data systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS ACQUISITION, PROTECTION, AND DISCLOSURE OF QUALITY IMPROVEMENT ORGANIZATION INFORMATION Utilization and Quality Control Quality Improvement Organizations (QIOs) Disclosure of Confidential Information § 480.143 QIO involvement in shared health data...

42 CFR 480.143 - QIO involvement in shared health data systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS ACQUISITION, PROTECTION, AND DISCLOSURE OF QUALITY IMPROVEMENT ORGANIZATION INFORMATION Utilization and Quality Control Quality Improvement Organizations (QIOs) Disclosure of Confidential Information § 480.143 QIO involvement in shared health data...

20 CFR 220.143 - Evaluation guides for an employed claimant.

Code of Federal Regulations, 2010 CFR

2010-04-01

... would not determine that the person worked at the substantial gainful activity level only on the basis... RETIREMENT ACT DETERMINING DISABILITY Substantial Gainful Activity § 220.143 Evaluation guides for an... done shows that he or she is able to do substantial gainful activity. (1) The claimant's earnings may...

20 CFR 220.143 - Evaluation guides for an employed claimant.

Code of Federal Regulations, 2011 CFR

2011-04-01

... would not determine that the person worked at the substantial gainful activity level only on the basis... RETIREMENT ACT DETERMINING DISABILITY Substantial Gainful Activity § 220.143 Evaluation guides for an... done shows that he or she is able to do substantial gainful activity. (1) The claimant's earnings may...

42 CFR 480.143 - QIO involvement in shared health data systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS ACQUISITION, PROTECTION, AND DISCLOSURE OF QUALITY IMPROVEMENT ORGANIZATION REVIEW INFORMATION Utilization and Quality Control Quality Improvement Organizations (QIOs) Disclosure of Confidential Information § 480.143 QIO involvement in shared health data...

42 CFR 480.143 - QIO involvement in shared health data systems.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS ACQUISITION, PROTECTION, AND DISCLOSURE OF QUALITY IMPROVEMENT ORGANIZATION REVIEW INFORMATION Utilization and Quality Control Quality Improvement Organizations (QIOs) Disclosure of Confidential Information § 480.143 QIO involvement in shared health data...

Small RNA sequencing and functional characterization reveals microRNA-143 tumor suppressor activity in liposarcoma

PubMed Central

Ugras, Stacy; Brill, Elliott; Jacobsen, Anders; Hafner, Markus; Socci, Nicholas D.; DeCarolis, Penelope L.; Khanin, Raya; O'Connor, Rachael; Mihailovic, Aleksandra; Taylor, Barry S.; Sheridan, Robert; Gimble, Jeffrey M.; Viale, Agnes; Crago, Aimee; Antonescu, Cristina R.; Sander, Chris; Tuschl, Thomas; Singer, Samuel

2011-01-01

Liposarcoma remains the most common mesenchymal cancer, with a mortality rate of 60% among patients with this disease. To address the present lack of therapeutic options, we embarked upon a study of microRNA (miRNA) expression alterations associated with liposarcomagenesis with the goal of exploiting differentially expressed miRNAs and the gene products they regulate as potential therapeutic targets. MicroRNA expression was profiled in samples of normal adipose tissue, well-differentiated liposarcoma, and dedifferentiated liposarcoma by both deep sequencing of small RNA libraries and hybridization-based Agilent microarrays. The expression profiles discriminated liposarcoma from normal adipose tissue and well-differentiated from dedifferentiated disease. We defined over 40 miRNAs that were dysregulated in dedifferentiated liposarcomas in both the sequencing and the microarray analysis. The upregulated miRNAs included two cancer-associated species (miR-21, miR-26a), and the downregulated miRNAs included two species that were highly abundant in adipose tissue (miR-143, miR-145). Restoring miR-143 expression in dedifferentiated liposarcoma cells inhibited proliferation, induced apoptosis, and decreased expression of BCL2, TOP2A, PRC1, and PLK1. The downregulation of PRC1 and its docking partner PLK1 suggests that miR-143 inhibits cytokinesis in these cells. In support of this idea, treatment with a PLK1 inhibitor potently induced G2/M growth arrest and apoptosis in liposarcoma cells. Taken together, our findings suggest that miR-143 re-expression vectors or selective agents directed at miR-143 or its targets may have therapeutic value in dedifferentiated liposarcoma. PMID:21693658

cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells.

PubMed

Zhou, Pei; Tu, Liqing; Lin, Xi; Hao, Xiangqi; Zheng, Qingxu; Zeng, Weijie; Zhang, Xin; Zheng, Yun; Wang, Lifang; Li, Shoujun

2017-11-25

MicroRNAs regulate multiple aspects of the host response to viral infection. This study verified that the expression of cfa-miR-143 was upregulated in vivo and in vitro by canine influenza virus (CIV) H3N2 infection. To understand the role of cfa-miR-143 in CIV-infected cells, the target gene of cfa-miR-143 was identified and assessed for correlations with proteins involved in the apoptosis pathway. A dual luciferase reporter assay showed that cfa-miR-143 targets insulin-like growth factor binding protein 5 (Igfbp5). Furthermore, a miRNA agomir and antagomir of cfa-miR-143 caused the downregulation and upregulation of Igfbp5, respectively, in CIV-infected madin-darby canine kidney (MDCK) cells. This study demonstrated that cfa-miR-143 stimulated p53 and caspase3 activation and induced apoptosis via the p53 pathway in CIV H3N2-infected cells. In conclusion, CIV H3N2 induced the upregulation of cfa-miR-143, which contributes to apoptosis via indirectly activating the p53-caspase3 pathway.

Rapid neodymium release to marine waters from lithogenic sediments in the Amazon estuary

PubMed Central

Rousseau, Tristan C. C.; Sonke, Jeroen E.; Chmeleff, Jérôme; van Beek, Pieter; Souhaut, Marc; Boaventura, Geraldo; Seyler, Patrick; Jeandel, Catherine

2015-01-01

Rare earth element (REE) concentrations and neodymium isotopic composition (ɛNd) are tracers for ocean circulation and biogeochemistry. Although models suggest that REE release from lithogenic sediment in river discharge may dominate all other REE inputs to the oceans, the occurrence, mechanisms and magnitude of such a source are still debated. Here we present the first simultaneous observations of dissolved (<0.45 μm), colloidal and particulate REE and ɛNd in the Amazon estuary. A sharp drop in dissolved REE in the low-salinity zone is driven by coagulation of colloidal matter. At mid-salinities, total dissolved REE levels slightly increase, while ɛNd values are shifted from the dissolved Nd river endmember (−8.9) to values typical of river suspended matter (−10.6). Combining a Nd isotope mass balance with apparent radium isotope ages of estuarine waters suggests a rapid (3 weeks) and globally significant Nd release by dissolution of lithogenic suspended sediments. PMID:26158849

[Effect of phosphate on the exchangeable form and the bioavailability of exogenous neodymium in soil].

PubMed

Xu, Z; Li, D; Yang, J; Peng, A

2001-05-01

Effects of phosphate on the exchangeable form and the bioavailability of exogenous neodymium (Nd) in soil were studied with 147Nd isotopic tracer. Exchangeable Nd was extracted with solution (pH8.2) of NaAc. The results indicated that Nd beyond 99.5% was adsorbed by soil whether phosphate exists in soil or not. Phosphate can precipitate dramatically Nd3+. And the Nd phosphate precipitates may set limits on the concentration of exchangeable Nd observed in soil. KH2PO4 ranging from 0.3 g.kg-1 to 1.5 g.kg-1 make a uniform impact on the exchangeable form of Nd. In addition, phosphate in soil can inhibit wheat seedling to absorb Nd. The concentration of exchangeable Nd is correlated significantly with the content of Nd in wheat seedling.

Analysis of a 10 megawatt space-based solar-pumped neodymium laser system

NASA Technical Reports Server (NTRS)

Kurweg, U. H.

1984-01-01

A ten megawatt solar-pumped continuous liquid laser system for space applications is examined. It is found that a single inflatable mirror of 434 m diameter used in conjunction with a conical secondary concentrator is sufficient to side pump a liquid neodymium lasant in an annular tube of 6 m length and 1 m outer and 0.8 m inner diameter. About one fourth of intercepted radiation converging on the laser tube is absorbed and one fifth of this radiation is effective in populating the upper levels. The liquid lasant is flowed through the annular laser cavity at 1.9 m/s and is cooled via a heat exchanger and a large radiator surface comparable in size to the concentrating mirror. The power density of incident light within the lasant of approximately 68 watt/cu cm required for cw operation is exceeded in the present annular configuration. Total system weight corresponds to 20,500 kg and is thus capable of being transported to near Earth orbit by a single shuttle flight.

42 CFR 137.143 - How is the funding level to which the Indian Tribe is entitled determined?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false How is the funding level to which the Indian Tribe is entitled determined? 137.143 Section 137.143 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF...

Effect of neodymium:YAG laser capsulotomy on visual function in patients with posterior capsule opacification and good visual acuity.

PubMed

Yotsukura, Erisa; Torii, Hidemasa; Saiki, Megumi; Negishi, Kazuno; Tsubota, Kazuo

2016-03-01

To evaluate the effect of neodymium:YAG (Nd:YAG) laser capsulotomy on the visual function in patients with posterior capsule opacification (PCO) and good visual acuity. Keio University Hospital, Tokyo, Japan. Observational case series. Eyes were evaluated that had previous cataract surgery with a clinical diagnosis of PCO requiring Nd:YAG laser capsulotomy regardless of a good corrected distance visual acuity (CDVA) (at least 20/20). The CDVA, 10% low contrast visual acuity (LCVA), wavefront aberrations from the 3rd to 6th order, and retinal straylight were measured before and after Nd:YAG laser capsulotomy. The study included 16 eyes of 16 patients (10 men, 6 women; mean age 69.5 years ± 9.3 [SD]). The mean CDVA, LCVA, and straylight after Nd:YAG laser capsulotomy improved significantly (P < .05). The root mean square (RMS) of the 3rd Zernike coefficients (S3) and the RMS of the total higher-order aberrations (HOAs) from the 3rd to 6th order decreased significantly after capsulotomy (P < .05). The straylight correlated significantly with the total HOAs (r = 0.727, P = .002) and S3 (r = 0.748, P = .001) before capsulotomy. Subjective symptoms resolved after capsulotomy in all cases. Neodymium:YAG laser capsulotomy enabled a significant improvement in visual function even in patients with PCO with good visual acuity. Straylight measurements might be useful to determine the indications for Nd:YAG laser capsulotomy when patients report visual disturbances without decreased visual acuity. Copyright © 2016 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for hypertrophic port-wine stains on the lips.

PubMed

Kono, Taro; Frederick Groff, William; Chan, Henry H; Sakurai, Hiroyuki; Yamaki, Takashi

2009-03-01

Pulsed dye laser (PDL) treatment of hypertrophic port-wine stains (PWSs) on the lips has demonstrated poor efficacy and a potential risk of dyspigmentation. PDL-resistant hypertrophic PWS may require treatment with deeper penetrating lasers such as a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. The objective of this clinical study was to evaluate the efficacy and safety of a Nd:YAG laser for the treatment of hypertrophic PWSs on the lips. Ten patients (four were male and six were female) with hypertrophic PWSs on the lips were recruited in this study. Eight patients showed good to excellent improvement without complications. In conclusion, the Nd:YAG laser is safe and effective for treating hypertrophic PWSs on the lips.

Optimization of diode-pumped doubly QML laser with neodymium-doped vanadate crystals at 1.34 μm

NASA Astrophysics Data System (ADS)

Zhang, Gang; Jiao, Zhiyong

2018-05-01

We present a theoretical model for a diode-pumped, 1.34 μm V3+:YAG laser that is equipped with an acoustic-optic modulator. The model includes the loss introduced by the acoustic-optic modulator combined with the physical properties of the laser resonator, the neodymium-doped vanadate crystals and the output coupler. The parameters are adjusted within a reasonable range to optimize the pulse output characteristics. A typical Q-switched and mode-locked Nd:Lu0.15Y0.85VO4 laser at 1.34 μm with acoustic-optic modulator and V3+:YAG is set up, and the experimental output characteristics are consistent with the theoretical simulation results.

Spectroscopic investigations of neodymium doped barium bismuth fluoroborate glasses

NASA Astrophysics Data System (ADS)

Mariselvam, K.; Arun Kumar, R.; Manasa, P.

2018-06-01

A new series of neodymium doped barium bismuth fluoroborate glasses with the chemical composition of (70-x)H3BO3 + 5Bi2O3 + 10BaCO3 + 7.5CaF2 + 7.5ZnO + xNd2O3 (where x = 0.05, 0.1, 0.25, 0.5, 1, 2 (in wt.%) have been prepared by the conventional melt quenching method. The powder X-ray diffraction pattern confirms the amorphous nature of the prepared glasses. The Urbach energy reveals the minimum disorderness of the glass samples. Judd-Ofelt intensity parameters (Ωλ = 2, 4 and 6) were derived from the absorption spectrum and were used to calculate the emission properties. The near infrared emission spectra recorded with 808 nm laser diode excitation for different concentrations of Nd3+ ions and the emission for the 4F3/2 → 4I11/2 transition at 1060 nm found to be high intense. The measured decay curves for 4F3/2 fluorescent level exhibit single exponential nature with shortening of lifetime with increase in concentration. The laser parameters such as stimulated emission cross-section, branching ratios, gain band width and optical gain values are found to be high for BBFB:Nd3+ (0.5 wt%) glass. Hence, the results suggested that the present BBFB:Nd3+ (0.5 wt%) glass could be used as an efficient infrared laser source around 1.06 μm region.

The contact neodymium-yttrium aluminum garnet laser. A new approach to arthroscopic laser surgery.

PubMed

O'Brien, S J; Miller, D V

1990-03-01

Arthroscopic treatment of meniscal lesions has been modified as technological advances have occurred. However, alternatives to conventional arthroscopic cutting tools, including electrocautery and CO2 lasers, have thus far met with limited success. The recent development of a sapphire tip has enabled the use of the neodymium-yttrium aluminum garnet (Nd-YAG) laser in a contact mode in a saline medium. This study compares the biology of the Nd-YAG laser to that of electrocautery and scalpel techniques with respect to its effects on articular cartilage and the meniscus. The contact Nd-YAG laser has advantages over both scalpel and electrocautery with regard to its effects on articular cartilage. It also has significant biologic advantages over electrocautery for meniscal lesions. Although in its infancy in the clinical setting, the contact Nd-YAG laser represents the possible beginning of a new era for application of laser energy in arthroscopy.

34. INTERIOR VIEW TO THE NORTH OF ROOMS 143 AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. INTERIOR VIEW TO THE NORTH OF ROOMS 143 AND 150, A FIRST FLOOR CORRIDOR AND VIEWING GALLERY ON THE EAST SIDE OF THE POST-MORTEM CELLS. VIEWING AND WORK STATIONS ARE IN THE NORTH AND WEST WALLS. - Nevada Test Site, Reactor Maintenance Assembly & Dissassembly Facility, Area 25, Jackass Flats, Junction of Roads F & G, Mercury, Nye County, NV

7 CFR 1956.143 - Debt restructuring-hospitals and health care facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 103-354 will consider the following criteria for selection: past experience in health care facility... 7 Agriculture 14 2011-01-01 2011-01-01 false Debt restructuring-hospitals and health care... Settlement-Community and Business Programs § 1956.143 Debt restructuring—hospitals and health care facilities...

78. Neg. No. F143A, Apr 1, 1932, INTERIORASSEMBLY BUILDING, CONVEYOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

78. Neg. No. F-143A, Apr 1, 1932, INTERIOR-ASSEMBLY BUILDING, CONVEYOR LINE WITH CAR CHASSIS - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

NONLINEAR OPTICAL EFFECTS AND FIBER OPTICS: Pulsed neodymium amplifier with phase conjugation and direct amplification

NASA Astrophysics Data System (ADS)

Basov, N. G.; Efimkov, V. F.; Zubarev, I. G.; Kolobrodov, V. V.; Pastukhov, S. A.; Smirnov, M. G.; Sobolev, V. B.

1988-12-01

A study was made of the characteristics of an amplifier containing neodymium-activated silicate rods, 45 mm in diameter, used in direct amplification and phase conjugation systems. At low output energies the divergence of the output radiation in the presence of a phase-conjugating mirror was half ( ~ 10- 4 rad) that in the case of direct amplification. An increase in the output power caused the divergence to rise more rapidly in the presence of a phase-conjugating mirror, which was tentatively attributed to an earlier manifestation of large-scale self-focusing. Output energies of 130 J in the case of direct amplification and 80 J in the presence of a phase-conjugating mirror were obtained when the output pulse duration was ~ 2 ns and the fraction of the total energy contained within an angle of ~ 10- 4 rad was ~ 0.3.

The novel long intergenic noncoding RNA UCC promotes colorectal cancer progression by sponging miR-143

PubMed Central

Huang, Feng-Ting; Chen, Wen-Ying; Gu, Zhi-Qiang; Zhuang, Yan-Yan; Li, Chu-Qiang; Wang, Ling-Yun; Peng, Juan-Fei; Zhu, Zhe; Luo, Xin; Li, Yuan-Hua; Yao, He-Rui; Zhang, Shi-Neng

2017-01-01

The human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. A novel lincRNA termed upregulated in CRC (UCC) was found to be highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node metastasis, Dukes’ stage, and patient outcomes. In SW480 and SW620 cells, knockdown of UCC inhibited proliferation, invasion, and cell cycle progression and induced apoptosis in vitro. Xenograft tumors grown from UCC-silenced SW620 cells had smaller mean volumes and formed more slowly than xenograft tumors grown from control cells. Inversely, overexpression of UCC in HCT116 promoted cell growth and invasion in vitro. Bioinformatics analysis, dual-luciferase reporter assays, and RNA immunoprecipitation assays showed that miR-143 can interact with UCC, and we found that UCC expression inversely correlates with miR-143 expression in CRC specimens. Moreover, mechanistic investigations showed that UCC may act as an endogenous sponge by competing for miR-143, thereby regulating the targets of this miRNA. Our results suggest that UCC and miR-143 may be promising molecular targets for CRC therapy. PMID:28492554

The novel long intergenic noncoding RNA UCC promotes colorectal cancer progression by sponging miR-143.

PubMed

Huang, Feng-Ting; Chen, Wen-Ying; Gu, Zhi-Qiang; Zhuang, Yan-Yan; Li, Chu-Qiang; Wang, Ling-Yun; Peng, Juan-Fei; Zhu, Zhe; Luo, Xin; Li, Yuan-Hua; Yao, He-Rui; Zhang, Shi-Neng

2017-05-11

The human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. A novel lincRNA termed upregulated in CRC (UCC) was found to be highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node metastasis, Dukes' stage, and patient outcomes. In SW480 and SW620 cells, knockdown of UCC inhibited proliferation, invasion, and cell cycle progression and induced apoptosis in vitro. Xenograft tumors grown from UCC-silenced SW620 cells had smaller mean volumes and formed more slowly than xenograft tumors grown from control cells. Inversely, overexpression of UCC in HCT116 promoted cell growth and invasion in vitro. Bioinformatics analysis, dual-luciferase reporter assays, and RNA immunoprecipitation assays showed that miR-143 can interact with UCC, and we found that UCC expression inversely correlates with miR-143 expression in CRC specimens. Moreover, mechanistic investigations showed that UCC may act as an endogenous sponge by competing for miR-143, thereby regulating the targets of this miRNA. Our results suggest that UCC and miR-143 may be promising molecular targets for CRC therapy.

22 CFR Appendix B to Part 143 - List of Affected Federal Financial Assistance

Code of Federal Regulations, 2010 CFR

2010-04-01

... Administered by the United States International Communication Agency Subject to Age Discrimination Regulations... AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Pt. 143, App. B Appendix B to...

Robustness of fossil fish teeth for seawater neodymium isotope reconstructions under variable redox conditions in an ancient shallow marine setting

NASA Astrophysics Data System (ADS)

Huck, Claire E.; van de Flierdt, Tina; Jiménez-Espejo, Francisco J.; Bohaty, Steven M.; Röhl, Ursula; Hammond, Samantha J.

2016-03-01

Fossil fish teeth from pelagic open ocean settings are considered a robust archive for preserving the neodymium (Nd) isotopic composition of ancient seawater. However, using fossil fish teeth as an archive to reconstruct seawater Nd isotopic compositions in different sedimentary redox environments and in terrigenous-dominated, shallow marine settings is less proven. To address these uncertainties, fish tooth and sediment samples from a middle Eocene section deposited proximal to the East Antarctic margin at Integrated Ocean Drilling Program Site U1356 were analyzed for major and trace element geochemistry, and Nd isotopes. Major and trace element analyses of the sediments reveal changing redox conditions throughout deposition in a shallow marine environment. However, variations in the Nd isotopic composition and rare earth element (REE) patterns of the associated fish teeth do not correspond to redox changes in the sediments. REE patterns in fish teeth at Site U1356 carry a typical mid-REE-enriched signature. However, a consistently positive Ce anomaly marks a deviation from a pure authigenic origin of REEs to the fish tooth. Neodymium isotopic compositions of cleaned and uncleaned fish teeth fall between modern seawater and local sediments and hence could be authigenic in nature, but could also be influenced by sedimentary fluxes. We conclude that the fossil fish tooth Nd isotope proxy is not sensitive to moderate changes in pore water oxygenation. However, combined studies on sediments, pore waters, fish teeth, and seawater are needed to fully understand processes driving the reconstructed signature from shallow marine sections in proximity to continental sources.

PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma.

PubMed

Hirahata, Mio; Osaki, Mitsuhiko; Kanda, Yusuke; Sugimoto, Yui; Yoshioka, Yusuke; Kosaka, Nobuyoshi; Takeshita, Fumitaka; Fujiwara, Tomohiro; Kawai, Akira; Ito, Hisao; Ochiya, Takahiro; Okada, Futoshi

2016-05-01

Despite recent improvements in the therapy for osteosarcoma, 30-40% of osteosarcoma patients die of this disease, mainly due to its lung metastasis. We have previously reported that intravenous injection of miR-143 significantly suppresses lung metastasis of human osteosarcoma cells (143B) in a mouse model. In this study, we examined the biological role and mechanism of miR-143 in the metastasis of human osteosarcoma cells. We identified plasminogen activator inhibitor-1 (PAI-1) as a direct target gene of miR-143. To determine the role of PAI-1 in human osteosarcoma cells, siRNA was transfected into 143B cells for knockdown of PAI-1 expression. An in vitro study showed that downregulation of PAI-1 suppressed cell invasion activity, but not proliferation. Moreover, injection of PAI-1 siRNA into a primary lesion in the osteosarcoma mouse model inhibited lung metastasis compared to control siRNA-injected mice, without influencing the proliferative activity of the tumor cells. Subsequent examination using 143B cells revealed that knockdown of PAI-1 expression resulted in downregulation of the expression and secretion of matrix metalloproteinase-13 (MMP-13), which is also a target gene of miR-143 and a proteolytic enzyme that regulates tumor-induced osteolysis. Immunohistochemical analysis using clinical samples showed that higher miR-143 expressing cases showed poor expression of PAI-1 in the primary tumor cells. All such cases belonged to the lung metastasis-negative group. Moreover, the frequency of lung metastasis-positive cases was significantly higher in PAI-1 and MMP-13 double-positive cases than in PAI-1 or MMP-13 single-positive or double-negative cases (P < 0.05). These results indicated that PAI-1, a target gene of miR-143, regulates invasion and lung metastasis via enhancement of MMP-13 expression and secretion in human osteosarcoma cells, suggesting that these molecules could be potential therapeutic target genes for preventing lung metastasis in

17 CFR 143.7 - Delegation of authority to the Executive Director.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Delegation of authority to the... JURISDICTION General Provisions § 143.7 Delegation of authority to the Executive Director. (a) The Commission... Commission employee under the Executive Director's supervision as he or she may designate, authority to take...

miR-143 suppresses epithelial-mesenchymal transition and inhibits tumor growth of breast cancer through down-regulation of ERK5.

PubMed

Zhai, Limin; Ma, Chuanxiang; Li, Wentong; Yang, Shuo; Liu, Zhijun

2016-12-01

Epithelial-mesenchymal transition (EMT) plays a pivotal role in the development of cancer invasion and metastasis. Many studies have significantly enhanced the knowledge on EMT through the characterization of microRNAs (miRNAs) influencing the signaling pathways and downstream events that define EMT on a molecular level. In this study, we found that miR-143 suppressed EMT. Up-regulating miR-143 enhanced E-cadherin-mediated cell-cell adhesion ability, reduced mesenchymal markers, and decreased cell proliferation, migration, and invasion in vitro. In vivo, the xenograft mouse model also unveiled the suppressive effects of miR-143 on tumor growth. Additionally, we demonstrated that up-regulating extracellular signal regulated kinase 5 (ERK5) was associated with poor prognosis of breast cancer patients. Moreover, we observed an inverse correlation between miR-143 and ERK5 in breast cancer tissues. miR-143 directly targeted seed sequences in the 3'-untranslated regions of ERK5. Furthermore, we revealed that the downstream molecules of glycogen synthase kinase 3 beta (GSK-3β)/Snail signaling were involved in EMT and modulated by ERK5. In summary, our findings demonstrated that miR-143 down-regulated its target ERK5, leading to the suppression of EMT induced by GSK-3β/Snail signaling of breast cancer. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Laser treatment of a neodymium magnet and analysis of surface characteristics

NASA Astrophysics Data System (ADS)

Yilbas, B. S.; Ali, H.; Rizwan, M.; Kassas, M.

2016-08-01

Laser treatment of neodymium magnet (Nd2Fe14B) surface is carried out under the high pressure nitrogen assisting gas. A thin carbon film containing 12% WC carbide particles with 400 nm sizes are formed at the surface prior to the laser treatment process. Morphological and metallurgical changes in the laser treated layer are examined using the analytical tools. The corrosion resistance of the laser treated surface is analyzed incorporating the potentiodynamic tests carried out in 0.05 M NaCl+0.1 M H2SO4 solution. The friction coefficient of the laser treated surface is measured using the micro-scratch tester. The wetting characteristics of the treated surface are assessed incorporating the sessile water drop measurements. It is found that a dense layer consisting of fine size grains and WC particles is formed in the surface region of the laser treated layer. Corrosion resistance of the surface improves significantly after the laser treatment process. Friction coefficient of laser treated surface is lower than that of the as received surface. Laser treatment results in superhydrophobic characteristics at the substrate surface. The formation of hematite and grain size variation in the treated layer slightly lowers the magnetic strength of the laser treated workpiece.

Rhenium-osmium and samarium-neodymium isotopic systematics of the stillwater complex

USGS Publications Warehouse

Lambert, D.D.; Morgan, J.W.; Walker, R.J.; Shirey, S.B.; Carlson, R.W.; Zientek, M.L.; Koski, M.S.

1989-01-01

Isotopic data for the Stillwater Complex, Montana , which formed about 2700 Ma (million years ago), were obtained to evaluate the role of magma mixing in the formation of strategic platinum-group element (PGE) ore deposits. Neodymium and osmium isotopic data indicate that the intrusion formed from at least two geochemically distinct magmas. Ultramafic affinity (U-type) magmas had initial ??Nd of -0.8 to -3.2 and a chondritic initial 187Os/186Os ratio of ???0.88, whereas anorthositic affinity (A-type) magmas had ??Nd of -0.7 to +1.7 and an initial 187Os/186Os ratio of ???1.13. These data suggest that U-type magmas were derived from a lithospheric mantle source containing recycled crustal materials whereas A-type magmas originated either by crustal contamination of basaltic magmas or by partial melting of basalt in the lower crust. The Nd and Os isotopic data also suggest that Os, and probably the other PGEs in ore horizons such as the J-M Reef, was derived from A-type magmas. The Nd and Os isotopic heterogeneity observed in rocks below the J-M Reef also suggests that A-type magmas were injected into the Stillwater U-type magma chamber at several stages during the development of the Ultramafic series.

Role of MicroRNA-143 in Nerve Injury-Induced Upregulation of Dnmt3a Expression in Primary Sensory Neurons

PubMed Central

Xu, Bo; Cao, Jing; Zhang, Jun; Jia, Shushan; Wu, Shaogen; Mo, Kai; Wei, Guihua; Liang, Lingli; Miao, Xuerong; Bekker, Alex; Tao, Yuan-Xiang

2017-01-01

Peripheral nerve injury increased the expression of the DNA methyltransferase 3A (Dnmt3a) mRNA and its encoding Dnmt3a protein in injured dorsal root ganglia (DRG). This increase is considered as an endogenous instigator in neuropathic pain genesis through epigenetic silencing of pain-associated genes (such as Oprm1) in injured DRG. However, how DRG DNMT3a is increased following peripheral nerve injury is still elusive. We reported here that peripheral nerve injury caused by the fifth spinal nerve ligation (SNL) downregulated microRNA (miR)-143 expression in injured DRG. This downregulation was required for SNL-induced DRG Dnmt3a increase as rescuing miR-143 downregulation through microinjection of miR-143 mimics into injured DRG blocked the SNL-induced increase in Dnmt3a and restored the SNL-induced decreases in Oprm1 mRNA and its encoding mu opioid receptor (MOR) in injured DRG, impaired spinal cord central sensitization and neuropathic pain, and improved morphine analgesic effects following SNL. Mimicking SNL-induced DRG miR-143 downregulation through DRG microinjection of miR143 inhibitors in naive rats increased the expression of Dnmt3a and reduced the expression of Oprm1 mRNA and MOR in injected DRG and produced neuropathic pain-like symptoms. These findings suggest that miR-143 is a negative regulator in Dnmt3a expression in the DRG under neuropathic pain conditions and may be a potential target for therapeutic management of neuropathic pain. PMID:29170626

Solution-processed high-mobility neodymium-substituted indium oxide thin-film transistors formed by facile patterning based on aqueous precursors

NASA Astrophysics Data System (ADS)

Lin, Zhenguo; Lan, Linfeng; Sun, Sheng; Li, Yuzhi; Song, Wei; Gao, Peixiong; Song, Erlong; Zhang, Peng; Li, Meiling; Wang, Lei; Peng, Junbiao

2017-03-01

Solution-processed neodymium-substituted indium oxide (InNdO) thin-film transistors (TFTs) based on gel-like aqueous precursors were fabricated with a surface-selective deposition technique associated with ultraviolet irradiation. The Nd concentration can be easily tuned by changing the ratio of Nd2O3 to In2O3 precursors. It was found that Nd played roles of suppressing grain growth, suppressing oxygen vacancy formation, and increasing the electrical stability of TFTs. The InNdO TFT with a Nd:In ratio of 0.02:1 exhibited a mobility of as high as 15.6 cm2 V-1 s-1 with improved stability under gate-bias stress.

Preparation and characterization of polystyrene/neodymium hydroxide (PS/Nd(OH)3) nano-composites

NASA Astrophysics Data System (ADS)

Alsewailem, Fares D.; Bagabas, Abdulaziz A.; Binkhodor, Yazeed A.

2018-03-01

Composites of polystyrene and Neodymium hydroxide nanrods (PS/Nd(OH)3) were formulated and characterized in this study. Cetyl (1-hexadccyl) trimethyl ammonium bromide (CTAB) was used as dispersion agent for the Nd(OH)3 rods in the PS matrix. PS/Nd(OH)3 composites were prepared by solution and melt compounding. Morphological, thermal, and mechanical properties of the prepared composites were investigated. CTAB was found to be more effective as dispersion agent in composites prepared by solution compounding in comparison with those prepared by melt compounding, and that was due to the mild conditions used in solution compounding. Nonetheless, impact strength of the composite at 0.5 wt% Nd(OH)3 was drastically reduced in the absence of CTAB. Both tensile and impact strengths were found to greatly decreased at higher loading of Nd(OH)3, e.g. 5 wt%, even with the use of CTAB. Thermal stability of the PS/Nd(OH)3 composites was noticeably increased at relatively low loading of Nd(OH)3, e.g. 0.5 wt%.

Scalable waveguide design for three-level operation in Neodymium doped fiber laser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pax, Paul H.; Khitrov, Victor V.; Drachenberg, Derrek R.

We have constructed a double clad neodymium doped fiber laser operating on the three-level 4F 3/2 → 4I 9/2 transition. The laser has produced 11.5 W at 925 nm with 55% slope efficiency when pumped at 808 nm, comparable to the best previous results for a double-clad fiber configuration on this transition. Higher power pumping with both 808 nm and 880 nm sources resulted in an output of 27 W, albeit at lower slope efficiency. In both cases, output power was limited by available pump, indicating the potential for further power scaling. To suppress the stronger four-level 4F 3/2 →more » 4I 11/2 transition we developed a waveguide that provides spectral filtering distributed along the length of the fiber, based on an all-solid micro-structured optical fiber design, with resonant inclusions creating a leakage path to the cladding. Furthermore, the waveguide supports large mode areas and provides strong suppression at selectable wavelength bands, thus easing the restrictions on core and cladding sizes that limited power scaling of previous approaches.« less

Scalable waveguide design for three-level operation in Neodymium doped fiber laser

DOE PAGES

Pax, Paul H.; Khitrov, Victor V.; Drachenberg, Derrek R.; ...

2016-12-12

We have constructed a double clad neodymium doped fiber laser operating on the three-level 4F 3/2 → 4I 9/2 transition. The laser has produced 11.5 W at 925 nm with 55% slope efficiency when pumped at 808 nm, comparable to the best previous results for a double-clad fiber configuration on this transition. Higher power pumping with both 808 nm and 880 nm sources resulted in an output of 27 W, albeit at lower slope efficiency. In both cases, output power was limited by available pump, indicating the potential for further power scaling. To suppress the stronger four-level 4F 3/2 →more » 4I 11/2 transition we developed a waveguide that provides spectral filtering distributed along the length of the fiber, based on an all-solid micro-structured optical fiber design, with resonant inclusions creating a leakage path to the cladding. Furthermore, the waveguide supports large mode areas and provides strong suppression at selectable wavelength bands, thus easing the restrictions on core and cladding sizes that limited power scaling of previous approaches.« less

Multiple Genetic Pathways Involving Amino Acid Position 143 of HIV-1 Integrase Are Preferentially Associated with Specific Secondary Amino Acid Substitutions and Confer Resistance to Raltegravir and Cross-Resistance to Elvitegravir

PubMed Central

Frantzell, Arne; Fransen, Signe; Petropoulos, Christos J.

2013-01-01

Y143C,R substitutions in HIV-1 integrase define one of three primary raltegravir (RAL) resistance pathways. Here we describe clinical isolates with alternative substitutions at position 143 (Y143A, Y143G, Y143H, and Y143S [Y143A,G,H,S]) that emerge less frequently, and we compare the genotypic and phenotypic profiles of these viruses to Y143C,R viruses to reconcile the preferential selection of Y143C,R variants during RAL treatment. Integrase amino acid sequences and RAL susceptibility were characterized in 117 patient isolates submitted for drug resistance testing and contained Y143 amino acid changes. The influence of specific Y143 substitutions on RAL susceptibility and their preferential association with particular secondary substitutions were further defined by evaluating the composition of patient virus populations along with a large panel of site-directed mutants. Our observations demonstrate that the RAL resistance profiles of Y143A,G,H,S viruses and their association with specific secondary substitutions are similar to the well-established Y143C profile but distinct from the Y143R profile. Y143R viruses differ from Y143A,C,G,H,S viruses in that Y143R confers a greater reduction in RAL susceptibility as a single substitution, consistent with a lower resistance barrier. Among Y143A,C,G,H,S viruses, the higher prevalence of Y143C viruses is the result of a lower genetic barrier than that of the Y143A,G,S viruses and a lower resistance barrier than that of the Y143H viruses. In addition, Y143A,C,G,H,S viruses require multiple secondary substitutions to develop large reductions in RAL susceptibility. Patient-derived viruses containing Y143 substitutions exhibit cross-resistance to elvitegravir. PMID:23733474

49 CFR 213.143 - Frog guard rails and guard faces; gage.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Frog guard rails and guard faces; gage. 213.143... and guard faces; gage. The guard check and guard face gages in frogs shall be within the limits... frog to the guard line 1 of its guard rail or guarding face, measured across the track at right angles...

49 CFR 213.143 - Frog guard rails and guard faces; gage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Frog guard rails and guard faces; gage. 213.143... and guard faces; gage. The guard check and guard face gages in frogs shall be within the limits... frog to the guard line 1 of its guard rail or guarding face, measured across the track at right angles...

49 CFR 213.143 - Frog guard rails and guard faces; gage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Frog guard rails and guard faces; gage. 213.143... and guard faces; gage. The guard check and guard face gages in frogs shall be within the limits... frog to the guard line 1 of its guard rail or guarding face, measured across the track at right angles...

49 CFR 213.143 - Frog guard rails and guard faces; gage.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Frog guard rails and guard faces; gage. 213.143... and guard faces; gage. The guard check and guard face gages in frogs shall be within the limits... frog to the guard line 1 of its guard rail or guarding face, measured across the track at right angles...

49 CFR 213.143 - Frog guard rails and guard faces; gage.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Frog guard rails and guard faces; gage. 213.143... and guard faces; gage. The guard check and guard face gages in frogs shall be within the limits... frog to the guard line 1 of its guard rail or guarding face, measured across the track at right angles...

Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143.

PubMed

Akao, Yukihiro; Kumazaki, Minami; Shinohara, Haruka; Sugito, Nobuhiko; Kuranaga, Yuki; Tsujino, Takuya; Yoshikawa, Yuki; Kitade, Yukio

2018-05-01

Despite considerable research on K-Ras inhibitors, none had been established until now. We synthesized nuclease-resistant synthetic miR-143 (miR-143#12), which strongly silenced K-Ras, its effector signal molecules AKT and ERK, and the K-Ras activator Sos1. We examined the anti-proliferative effect of miR-143#12 and the mechanism in human colon cancer DLD-1 cell (G13D) and other cell types harboring K-Ras mutations. Cell growth was markedly suppressed in a concentration-dependent manner by miR-143#12 (IC 50 : 1.32 nmol L -1 ) with a decrease in the K-Ras mRNA level. Interestingly, this mRNA level was also downregulated by either a PI3K/AKT or MEK inhibitor, which indicates a positive circuit of K-Ras mRNA expression. MiR-143#12 silenced cytoplasmic K-Ras mRNA expression and impaired the positive circuit by directly targeting AKT and ERK mRNA. Combination treatment with miR-143#12 and a low-dose EGFR inhibitor induced a synergistic inhibition of growth with a marked inactivation of both PI3K/AKT and MAPK/ERK signaling pathways. However, silencing K-Ras by siR-KRas instead of miR-143#12 did not induce this synergism through the combined treatment with the EGFR inhibitor. Thus, miR-143#12 perturbed the K-Ras expression system and K-Ras activation by silencing Sos1 and, resultantly, restored the efficacy of the EGFR inhibitors. The in vivo results also supported those of the in vitro experiments. The extremely potent miR-143#12 enabled us to understand K-Ras signaling networks and shut them down by combination treatment with this miRNA and EGFR inhibitor in K-Ras-driven colon cancer cell lines. © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Deep intronic GPR143 mutation in a Japanese family with ocular albinism.

PubMed

Naruto, Takuya; Okamoto, Nobuhiko; Masuda, Kiyoshi; Endo, Takao; Hatsukawa, Yoshikazu; Kohmoto, Tomohiro; Imoto, Issei

2015-06-10

Deep intronic mutations are often ignored as possible causes of human disease. Using whole-exome sequencing, we analysed genomic DNAs of a Japanese family with two male siblings affected by ocular albinism and congenital nystagmus. Although mutations or copy number alterations of coding regions were not identified in candidate genes, the novel intronic mutation c.659-131 T > G within GPR143 intron 5 was identified as hemizygous in affected siblings and as heterozygous in the unaffected mother. This mutation was predicted to create a cryptic splice donor site within intron 5 and activate a cryptic acceptor site at 41nt upstream, causing the insertion into the coding sequence of an out-of-frame 41-bp pseudoexon with a premature stop codon in the aberrant transcript, which was confirmed by minigene experiments. This result expands the mutational spectrum of GPR143 and suggests the utility of next-generation sequencing integrated with in silico and experimental analyses for improving the molecular diagnosis of this disease.

Substitutions at Amino Acid Positions 143, 148, and 155 of HIV-1 Integrase Define Distinct Genetic Barriers to Raltegravir Resistance In Vivo

PubMed Central

Fransen, Signe; Gupta, Soumi; Frantzell, Arne; Petropoulos, Christos J.

2012-01-01

Mutations at amino acids 143, 148, and 155 in HIV-1 integrase (IN) define primary resistance pathways in subjects failing raltegravir (RAL)-containing treatments. Although each pathway appears to be genetically distinct, shifts in the predominant resistant virus population have been reported under continued drug pressure. To better understand this dynamic, we characterized the RAL susceptibility of 200 resistant viruses, and we performed sequential clonal analysis for selected cases. Patient viruses containing Y143R, Q148R, or Q148H mutations consistently exhibited larger reductions in RAL susceptibility than patient viruses containing N155H mutations. Sequential analyses of virus populations from three subjects revealed temporal shifts in subpopulations representing N155H, Y143R, or Q148H escape pathways. Evaluation of molecular clones isolated from different time points demonstrated that Y143R and Q148H variants exhibited larger reductions in RAL susceptibility and higher IN-mediated replication capacity (RC) than N155H variants within the same subject. Furthermore, shifts from the N155H pathway to either the Q148R or H pathway or the Y143R pathway were dependent on the amino acid substitution at position 148 and the secondary mutations in Y143R- or Q148R- or H-containing variants and correlated with reductions in RAL susceptibility and restorations in RC. Our observations in patient viruses were confirmed by analyzing site-directed mutations. In summary, viruses that acquire mutations defining the 143 or 148 escape pathways are less susceptible to RAL and exhibit greater RC than viruses containing 155 pathway mutations. These selective pressures result in the displacement of N155H variants by 143 or 148 variants under continued drug exposure. PMID:22553340

Bulkiness or aromatic nature of tyrosine-143 of actin is important for the weak binding between F-actin and myosin-ADP-phosphate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gomibuchi, Yuki; Uyeda, Taro Q.P.; Wakabayashi, Takeyuki, E-mail: tw007@nasu.bio.teikyo-u.ac.jp

2013-11-29

Highlights: •The effect of mutation of Tyr143 that becomes more exposed on assembly was examined. •Mutation of tyrosine-143 of Dictyostelium actin changed actin polymerizability. •The bulkiness or aromatic nature of Tyr143 is important for the weak binding. •The weak interaction between myosin and actin strengthened by Tyr143Trp mutation. -- Abstract: Actin filaments (F-actin) interact with myosin and activate its ATPase to support force generation. By comparing crystal structures of G-actin and the quasi-atomic model of F-actin based on high-resolution cryo-electron microscopy, the tyrosine-143 was found to be exposed more than 60 Å{sup 2} to the solvent in F-actin. Because tyrosine-143more » flanks the hydrophobic cleft near the hydrophobic helix that binds to myosin, the mutant actins, of which the tyrosine-143 was replaced with tryptophan, phenylalanine, or isoleucine, were generated using the Dictyostelium expression system. It polymerized significantly poorly when induced by NaCl, but almost normally by KCl. In the presence of phalloidin and KCl, the extents of the polymerization of all the mutant actins were comparable to that of the wild-type actin so that the actin-activated myosin ATPase activity could be reliably compared. The affinity of skeletal heavy meromyosin to F-actin and the maximum ATPase activity (V{sub max}) were estimated by a double reciprocal plot. The Tyr143Trp-actin showed the higher affinity (smaller K{sub app}) than that of the wild-type actin, with the V{sub max} being almost unchanged. The K{sub app} and V{sub max} of the Tyr143Phe-actin were similar to those of the wild-type actin. However, the activation by Tyr143Ile-actin was much smaller than the wild-type actin and the accurate determination of K{sub app} was difficult. Comparison of the myosin ATPase activated by the various mutant actins at the same concentration of F-actin showed that the extent of activation correlates well with the solvent-accessible surface areas

Absorption spectra of 4f electron transitions of neodymium and erbium with 8-hydroxyquinoline-5-sulphonic acid and diethylamine systems and its analytical application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang Naixing; Qi Ping

1992-06-01

In this paper the absorption spectra of 4f electron transitions of the systems of neodymium and erbium with 8-hydroxyquinoline-5-sulphonic acid and diethylamine have been studied by normal and third-derivative spectrophotometry. Their molar absorptivities are 80 1.mol{sup {minus}1}.cm{sup {minus}1} for neodymium and 65 1.mol{sup {minus}1}.cm{sup {minus}1} for erbium. Use of the third-derivative spectra, eliminates the interference by other rare earths and increases the sensitivity for Nd and Er. The derivative molar absorptivities are 390 1.mol{sup {minus}1}.cm{sup {minus}1} for Nd and 367 1.mol{sup {minus}1}.cm{sup {minus}1} for Er. The calibration graphs were linear up to 11.8 {mu}g/ml of Nd and 12.3 {mu}g/ml ofmore » Er, respectively. The relative standard deviations evaluated from eleven independent determinations of 7.2 {mu}g/ml (for Nd) and 8.3 {mu}g/ml (for Er) are 1.3% and 1.4%, respectively. The detection limits are 0.2 {mu}g/ml for Nd and 0.3 {mu}g/ml for Er. The method has been developed for determining those two elements in mixture of lanthanides by means of the third-derivative spectra and the analytical results obtained are satisfactory.« less

lncRNA CCAT1 promotes cell proliferation, migration, and invasion by down-regulation of miR-143 in FTC-133 thyroid carcinoma cell line.

PubMed

Yang, Tianzheng; Zhai, Hongyan; Yan, Ruihong; Zhou, Zhenhu; Gao, Lei; Wang, Luqing

2018-01-01

Thyroid cancer is a common malignant tumor. Long non-coding RNA colon cancer-associated transcript 1 (lncRNA CCAT1) is highly expressed in many cancers; however, the molecular mechanism of CCAT1 in thyroid cancer remains unclear. Hence, this study aimed to investigate the effect of CCAT1 on human thyroid cancer cell line FTC-133. FTC-133 cells were transfected with CCAT1 expressing vector, CCAT1 shRNA, miR-143 mimic, and miR-143 inhibitor, respectively. After different treatments, cell viability, proliferation, migration, invasion, and apoptosis were measured. Moreover, the regulatory relationship of CCAT1 and miR-143, as well as miR-143 and VEGF were tested using dual-luciferase reporter assay. The relative expressions of CCAT1, miR-143, and VEGF were tested by qRT-PCR. The expressions of apoptosis-related factors and corresponding proteins in PI3K/AKT and MAPK pathways were analyzed using western blot analysis. The results suggested that CCAT1 was up-regulated in the FTC-133 cells. CCAT1 suppression decreased FTC-133 cell viability, proliferation, migration, invasion, and miR-143 expression, while it increased apoptosis and VEGF expression. CCAT1 might act as a competing endogenous RNA (ceRNA) for miR-143. Moreover, CCAT1 activated PI3K/AKT and MAPK signaling pathways through inhibition of miR-143. This study demonstrated that CCAT1 exhibited pro-proliferative and pro-metastasis functions on FTC-133 cells and activated PI3K/AKT and MAPK signaling pathways via down-regulation of miR-143. These findings will provide a possible target for clinical treatment of thyroid cancer.

143. ARAIII Control building (ARA607) Floor plan. Shows control room, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

143. ARA-III Control building (ARA-607) Floor plan. Shows control room, contaminated work area, counting and computer room, health physics room, instrument repair room, offices, and other rooms. Aerojet-general 880-area/GCRE-607-A-1. Date: February 1958. Ineel index code no. 063-0607-00-013-102546. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

147Sm-143Nd systematics of Earth are inconsistent with a superchondritic Sm/Nd ratio

PubMed Central

Huang, Shichun; Jacobsen, Stein B.; Mukhopadhyay, Sujoy

2013-01-01

The relationship between the compositions of the Earth and chondritic meteorites is at the center of many important debates. A basic assumption in most models for the Earth’s composition is that the refractory elements are present in chondritic proportions relative to each other. This assumption is now challenged by recent 142Nd/144Nd ratio studies suggesting that the bulk silicate Earth (BSE) might have an Sm/Nd ratio 6% higher than chondrites (i.e., the BSE is superchondritic). This has led to the proposal that the present-day 143Nd/144Nd ratio of BSE is similar to that of some deep mantle plumes rather than chondrites. Our reexamination of the long-lived 147Sm-143Nd isotope systematics of the depleted mantle and the continental crust shows that the BSE, reconstructed using the depleted mantle and continental crust, has 143Nd/144Nd and Sm/Nd ratios close to chondritic values. The small difference in the ratio of 142Nd/144Nd between ordinary chondrites and the Earth must be due to a process different from mantle-crust differentiation, such as incomplete mixing of distinct nucleosynthetic components in the solar nebula. PMID:23479630

Rare earth elements and neodymium isotopes in sedimentary organic matter

NASA Astrophysics Data System (ADS)

Freslon, Nicolas; Bayon, Germain; Toucanne, Samuel; Bermell, Sylvain; Bollinger, Claire; Chéron, Sandrine; Etoubleau, Joel; Germain, Yoan; Khripounoff, Alexis; Ponzevera, Emmanuel; Rouget, Marie-Laure

2014-09-01

We report rare earth element (REE) and neodymium (Nd) isotope data for the organic fraction of sediments collected from various depositional environments, i.e. rivers (n = 25), estuaries (n = 18), open-ocean settings (n = 15), and cold seeps (n = 12). Sedimentary organic matter (SOM) was extracted using a mixed hydrogen peroxide/nitric acid solution (20%-H2O2-0.02 M-HNO3), after removal of carbonate and oxy-hydroxide phases with dilute hydrochloric acid (0.25 M-HCl). A series of experimental tests indicate that extraction of sedimentary organic compounds using H2O2 may be complicated occasionally by partial dissolution of sulphide minerals and residual carbonates. However, this contamination is expected to be minor for REE because measured concentrations in H2O2 leachates are about two-orders of magnitude higher than in the above mentioned phases. The mean REE concentrations determined in the H2O2 leachates for samples from rivers, estuaries, coastal seas and open-ocean settings yield relatively similar levels, with ΣREE = 109 ± 86 ppm (mean ± s; n = 58). The organic fractions leached from cold seep sediments display even higher concentration levels (285 ± 150 ppm; mean ± s; n = 12). The H2O2 leachates for most sediments exhibit remarkably similar shale-normalized REE patterns, all characterized by a mid-REE enrichment compared to the other REE. This suggests that the distribution of REE in leached sedimentary organic phases is controlled primarily by biogeochemical processes, rather than by the composition of the source from which they derive (e.g. pore, river or sea-water). The Nd isotopic compositions for organic phases leached from river sediments are very similar to those for the corresponding detrital fractions. In contrast, the SOM extracted from marine sediments display εNd values that typically range between the εNd signatures for terrestrial organic matter (inferred from the analysis of the sedimentary detrital fractions) and marine organic matter

Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I)

PubMed Central

Lim, Sze Chern; Carey, Kirstyn T; McKenzie, Matthew

2015-01-01

Isoflavonoids have been shown to inhibit tumor proliferation and metastasis by activating cell death pathways. As such, they have been widely studied as potential therapies for cancer prevention. The second generation synthetic isoflavan analogues ME-143 and ME-344 also exhibit anti-cancer effects, however their specific molecular targets have not been completely defined. To identify these targets, we examined the effects of ME-143 and ME-344 on cellular metabolism and found that they are potent inhibitors of mitochondrial oxidative phosphorylation (OXPHOS) complex I (NADH: ubiquinone oxidoreductase) activity. In isolated HEK293T mitochondria, ME-143 and ME-344 reduced complex I activity to 14.3% and 28.6% of control values respectively. In addition to the inhibition of complex I, ME-344 also significantly inhibited mitochondrial complex III (ubiquinol: ferricytochrome-c oxidoreductase) activity by 10.8%. This inhibition of complex I activity (and to a lesser extent complex III activity) was associated with a reduction in mitochondrial oxygen consumption. In permeabilized HEK293T cells, ME-143 and ME-344 significantly reduced the maximum ADP-stimulated respiration rate to 62.3% and 70.0% of control levels respectively in the presence of complex I-linked substrates. Conversely, complex II-linked respiration was unaffected by either drug. We also observed that the inhibition of complex I-linked respiration caused the dissipation of the mitochondrial membrane potential (ΔΨm). Blue native (BN-PAGE) analysis revealed that prolonged loss of ΔΨm results in the destabilization of the native OXPHOS complexes. In particular, treatment of 143B osteosarcoma, HeLa and HEK293T human embryonic kidney cells with ME-344 for 4 h resulted in reduced steady-state levels of mature complex I. Degradation of the complex I subunit NDUFA9, as well as the complex IV (ferrocytochrome c: oxygen oxidoreductase) subunit COXIV, was also evident. The identification of OXPHOS complex I as a

Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I).

PubMed

Lim, Sze Chern; Carey, Kirstyn T; McKenzie, Matthew

2015-01-01

Isoflavonoids have been shown to inhibit tumor proliferation and metastasis by activating cell death pathways. As such, they have been widely studied as potential therapies for cancer prevention. The second generation synthetic isoflavan analogues ME-143 and ME-344 also exhibit anti-cancer effects, however their specific molecular targets have not been completely defined. To identify these targets, we examined the effects of ME-143 and ME-344 on cellular metabolism and found that they are potent inhibitors of mitochondrial oxidative phosphorylation (OXPHOS) complex I (NADH: ubiquinone oxidoreductase) activity. In isolated HEK293T mitochondria, ME-143 and ME-344 reduced complex I activity to 14.3% and 28.6% of control values respectively. In addition to the inhibition of complex I, ME-344 also significantly inhibited mitochondrial complex III (ubiquinol: ferricytochrome-c oxidoreductase) activity by 10.8%. This inhibition of complex I activity (and to a lesser extent complex III activity) was associated with a reduction in mitochondrial oxygen consumption. In permeabilized HEK293T cells, ME-143 and ME-344 significantly reduced the maximum ADP-stimulated respiration rate to 62.3% and 70.0% of control levels respectively in the presence of complex I-linked substrates. Conversely, complex II-linked respiration was unaffected by either drug. We also observed that the inhibition of complex I-linked respiration caused the dissipation of the mitochondrial membrane potential (ΔΨm). Blue native (BN-PAGE) analysis revealed that prolonged loss of ΔΨm results in the destabilization of the native OXPHOS complexes. In particular, treatment of 143B osteosarcoma, HeLa and HEK293T human embryonic kidney cells with ME-344 for 4 h resulted in reduced steady-state levels of mature complex I. Degradation of the complex I subunit NDUFA9, as well as the complex IV (ferrocytochrome c: oxygen oxidoreductase) subunit COXIV, was also evident. The identification of OXPHOS complex I as a

Histochemistry of nerve fibres double labelled with anti-TRPV2 antibodies and sensory nerve marker AM1-43 in the dental pulp of rat molars.

PubMed

Nishikawa, Sumio

2008-09-01

AM1-43 can label sensory nerve fibres and sensory neurons. Permeation of non-selective cation channels of the nerve cell membrane is suggested to be the mechanism responsible for labelling. To identify these channels, two candidates, TRPV1 and TRPV2 were examined by immunocytochemistry in the dental pulp and trigeminal ganglion of rats injected with AM1-43. A part of AM1-43-labelled nerve fibres was also positive for anti-TRPV2 antibody but negative for anti-TRPV1 antibody in the dental pulp. In the trigeminal ganglion, a part of the neuron showed both bright AM1-43 labelling and anti-TRPV2 immunolabelling, but neurons double labelled with AM1-43 and TRPV1 were rare. These results suggest that TRPV2 channels, but not TRPV1 channels, contribute to the fluorescent labelling of AM1-43 in the dental pulp.

Discovery of an Ultraviolet Counterpart to an Ultrafast X-Ray Outflow in the Quasar PG 1211+143

NASA Astrophysics Data System (ADS)

Kriss, Gerard A.; Lee, Julia C.; Danehkar, Ashkbiz; Nowak, Michael A.; Fang, Taotao; Hardcastle, Martin J.; Neilsen, Joseph; Young, Andrew

2018-02-01

We observed the quasar PG 1211+143 using the Cosmic Origins Spectrograph on the Hubble Space Telescope in 2015 April as part of a joint campaign with the Chandra X-ray Observatory and the Jansky Very Large Array. Our ultraviolet spectra cover the wavelength range 912–2100 Å. We find a broad absorption feature (∼ 1080 {km} {{{s}}}-1) at an observed wavelength of 1240 Å. Interpreting this as H I Lyα, in the rest frame of PG 1211+143 (z = 0.0809), this corresponds to an outflow velocity of ‑16,980 {km} {{{s}}}-1 (outflow redshift {z}{out}∼ -0.0551), matching the moderate ionization X-ray absorption system detected in our Chandra observation and reported previously by Pounds et al. With a minimum H I column density of {log} {N}{{H}{{I}}}> 14.5, and no absorption in other UV resonance lines, this Lyα absorber is consistent with arising in the same ultrafast outflow as the X-ray absorbing gas. The Lyα feature is weak or absent in archival ultraviolet spectra of PG 1211+143, strongly suggesting that this absorption is transient, and intrinsic to PG 1211+143. Such a simultaneous detection in two independent wavebands for the first time gives strong confirmation of the reality of an ultrafast outflow in an active galactic nucleus.

MicroRNA-143-3p inhibits hyperplastic scar formation by targeting connective tissue growth factor CTGF/CCN2 via the Akt/mTOR pathway.

PubMed

Mu, Shengzhi; Kang, Bei; Zeng, Weihui; Sun, Yaowen; Yang, Fan

2016-05-01

Post-traumatic hypertrophic scar (HS) is a fibrotic disease with excessive extracellular matrix (ECM) production, which is a response to tissue injury by fibroblasts. Although emerging evidence has indicated that miRNA contributes to hypertrophic scarring, the role of miRNA in HS formation remains unclear. In this study, we found that miR-143-3p was markedly downregulated in HS tissues and fibroblasts (HSFs) using qRT-PCR. The expression of connective tissue growth factor (CTGF/CCN2) was upregulated both in HS tissues and HSFs, which is proposed to play a key role in ECM deposition in HS. The protein expression of collagen I (Col I), collagen III (Col III), and α-smooth muscle actin (α-SMA) was obviously inhibited after treatment with miR-143-3p in HSFs. The CCK-8 assay showed that miR-143-3p transfection reduced the proliferation ability of HSFs, and flow cytometry showed that either early or late apoptosis of HSFs was upregulated by miR-143-3p. In addition, the activity of caspase 3 and caspase 9 was increased after miR-143-3p transfection. On the contrary, the miR-143-3p inhibitor was demonstrated to increase cell proliferation and inhibit apoptosis of HSFs. Moreover, miR-143-3p targeted the 3'-UTR of CTGF and caused a significant decrease of CTGF. Western blot demonstrated that Akt/mTOR phosphorylation and the expression of CTGF, Col I, Col III, and α-SMA were inhibited by miR-143-3p, but increased by CTGF overexpression. In conclusion, we found that miR-143-3p inhibits hypertrophic scarring by regulating the proliferation and apoptosis of human HSFs, inhibiting ECM production-associated protein expression by targeting CTGF, and restraining the Akt/mTOR pathway.

High-resolution separation of neodymium and dysprosium ions utilizing extractant-impregnated graft-type particles.

PubMed

Uchiyama, Shoichiro; Sasaki, Takaaki; Ishihara, Ryo; Fujiwara, Kunio; Sugo, Takanobu; Umeno, Daisuke; Saito, Kyoichi

2018-01-19

An efficient method for rare metal recovery from environmental water and urban mines is in high demand. Toward rapid and high-resolution rare metal ion separation, a novel bis(2-ethylhexyl) phosphate (HDEHP)-impregnated graft-type particle as a filler for a chromatography column is proposed. To achieve rapid and high-resolution separation, a convection-flow-aided elution mode is required. The combination of 35 μm non-porous particles and a polymer-brush-rich particle structure minimizes the distance from metal ion binding sites to the convection flow in the column, resulting in minimized diffusional mass transfer resistance and the convection-flow-aided elution mode. The HDEHP-impregnated graft-type non-porous-particle-packed cartridge developed in this study exhibited a higher separation performance for model rare metals, neodymium (III) and dysprosium (III) ions, and a narrower peak at a higher linear velocity, than those of previous HDEHP-impregnated fiber-packed and commercially available Lewatit ® VP OC 1026-packed cartridges. Copyright © 2017 Elsevier B.V. All rights reserved.

17 CFR 230.143 - Definition of “has purchased”, “sells for”, “participates”, and “participation”, as used in...

Code of Federal Regulations, 2010 CFR

2010-04-01

... transactions of foreign governments for war purposes. 230.143 Section 230.143 Commodity and Securities... section 2(11), in relation to certain transactions of foreign governments for war purposes. The terms has.... 77b), shall not be deemed to apply to any action of a foreign government in acquiring, for war...

Tunicate cytostatic factor TC14-3 induces a polycomb group gene and histone modification through Ca2+ binding and protein dimerization

PubMed Central

2012-01-01

Background As many invertebrate species have multipotent cells that undergo cell growth and differentiation during regeneration and budding, many unique and interesting homeostatic factors are expected to exist in those animals. However, our understanding of such factors and global mechanisms remains very poor. Single zooids of the tunicate, Polyandrocarpa misakiensis, can give off as many as 40 buds during the life span. Bud development proceeds by means of transdifferentiation of very limited number of cells and tissues. TC14-3 is one of several different but closely related polypeptides isolated from P. misakiensis. It acts as a cytostatic factor that regulates proliferation, adhesion, and differentiation of multipotent cells, although the molecular mechanism remains uncertain. The Polycomb group (PcG) genes are involved in epigenetic control of genomic activity in mammals. In invertebrates except Drosophila, PcG and histone methylation have not been studied so extensively, and genome-wide gene regulation is poorly understood. Results When Phe65 of TC14-3 was mutated to an acidic amino acid, the resultant mutant protein failed to dimerize. The replacement of Thr69 with Arg69 made dimers unstable. When Glu106 was changed to Gly106, the resultant mutant protein completely lost Ca2+ binding. All these mutant proteins lacked cytostatic activity, indicating the requirement of protein dimerization and calcium for the activity. Polyandrocarpa Eed, a component of PcG, is highly expressed during budding, like TC14-3. When wild-type and mutant TC14-3s were applied in vivo and in vitro to Polyandrocarpa cells, only wild-type TC14-3 could induce Eed without affecting histone methyltransferase gene expression. Eed-expressing cells underwent trimethylation of histone H3 lysine27. PmEed knockdown by RNA interference rescued cultured cells from the growth-inhibitory effects of TC14-3. Conclusion These results show that in P. misakiensis, the cytostatic activity of TC14-3 is

29 CFR 4.143 - Effects of changes or extensions of contracts, generally.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Application of the McNamara-O'Hara Service Contract Act Changes in Contract Coverage § 4.143 Effects of... purposes of the application of the Act's provisions. The general rule with respect to such contracts is... provisions of the Act and the regulations thereunder will apply to the changed contract in the same manner...

11 CFR 100.143 - Brokerage loans and lines of credit to candidates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... card, home equity line of credit, or other line of credit available to the candidate, as described in... 11 Federal Elections 1 2010-01-01 2010-01-01 false Brokerage loans and lines of credit to... DEFINITIONS (2 U.S.C. 431) Exceptions to Expenditures § 100.143 Brokerage loans and lines of credit to...

11 CFR 100.143 - Brokerage loans and lines of credit to candidates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... card, home equity line of credit, or other line of credit available to the candidate, as described in... 11 Federal Elections 1 2012-01-01 2012-01-01 false Brokerage loans and lines of credit to... DEFINITIONS (2 U.S.C. 431) Exceptions to Expenditures § 100.143 Brokerage loans and lines of credit to...

11 CFR 100.143 - Brokerage loans and lines of credit to candidates.

Code of Federal Regulations, 2014 CFR

2014-01-01

... card, home equity line of credit, or other line of credit available to the candidate, as described in... 11 Federal Elections 1 2014-01-01 2014-01-01 false Brokerage loans and lines of credit to... DEFINITIONS (2 U.S.C. 431) Exceptions to Expenditures § 100.143 Brokerage loans and lines of credit to...

11 CFR 100.143 - Brokerage loans and lines of credit to candidates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... card, home equity line of credit, or other line of credit available to the candidate, as described in... 11 Federal Elections 1 2011-01-01 2011-01-01 false Brokerage loans and lines of credit to... DEFINITIONS (2 U.S.C. 431) Exceptions to Expenditures § 100.143 Brokerage loans and lines of credit to...

11 CFR 100.143 - Brokerage loans and lines of credit to candidates.

Code of Federal Regulations, 2013 CFR

2013-01-01

... card, home equity line of credit, or other line of credit available to the candidate, as described in... 11 Federal Elections 1 2013-01-01 2012-01-01 true Brokerage loans and lines of credit to... DEFINITIONS (2 U.S.C. 431) Exceptions to Expenditures § 100.143 Brokerage loans and lines of credit to...

46 CFR 502.143 - Notice of nature of hearing, jurisdiction and issues.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 9 2012-10-01 2012-10-01 false Notice of nature of hearing, jurisdiction and issues... RULES OF PRACTICE AND PROCEDURE Hearings; Presiding Officers; Evidence § 502.143 Notice of nature of... complaint served under § 502.113, will be duly and timely informed of (a) the nature of the proceeding, (b...

46 CFR 502.143 - Notice of nature of hearing, jurisdiction and issues.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 9 2010-10-01 2010-10-01 false Notice of nature of hearing, jurisdiction and issues... RULES OF PRACTICE AND PROCEDURE Hearings; Presiding Officers; Evidence § 502.143 Notice of nature of... complaint served under § 502.113, will be duly and timely informed of (a) the nature of the proceeding, (b...

46 CFR 502.143 - Notice of nature of hearing, jurisdiction and issues.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 9 2014-10-01 2014-10-01 false Notice of nature of hearing, jurisdiction and issues... RULES OF PRACTICE AND PROCEDURE Hearings; Presiding Officers; Evidence § 502.143 Notice of nature of... complaint served under § 502.113, will be duly and timely informed of (a) the nature of the proceeding, (b...

46 CFR 502.143 - Notice of nature of hearing, jurisdiction and issues.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 9 2011-10-01 2011-10-01 false Notice of nature of hearing, jurisdiction and issues... RULES OF PRACTICE AND PROCEDURE Hearings; Presiding Officers; Evidence § 502.143 Notice of nature of... complaint served under § 502.113, will be duly and timely informed of (a) the nature of the proceeding, (b...

46 CFR 502.143 - Notice of nature of hearing, jurisdiction and issues.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 9 2013-10-01 2013-10-01 false Notice of nature of hearing, jurisdiction and issues... RULES OF PRACTICE AND PROCEDURE Hearings; Presiding Officers; Evidence § 502.143 Notice of nature of... complaint served under § 502.113, will be duly and timely informed of (a) the nature of the proceeding, (b...

Recent Progress in the Development of Neodymium Doped Ceramic Yttria

NASA Technical Reports Server (NTRS)

Prasad, Narasimha S.; Edwards, Chris; Trivedi, Sudhir B.; Kutcher, Susan; Wang, Chen-Chia; Kim, Joo-Soo; Hommerich, Uwe; Shukla, Vijay; Sadangi, Rajendra; Kear, Bernard

2007-01-01

Solid-state lasers play a significant role in providing the technology necessary for active remote sensing of the atmosphere. Neodymium doped yttria (Nd:Y2O3) is considered to be an attractive material due to its possible lasing wavelengths of aprrox.914 nm and approx.946 nm for ozone profiling. These wavelengths when frequency tripled can generate UV light at approx.305 nm and approx.315 nm, which is particularly useful for ozone sensing using differential absorption lidar technique. For practical realization of space based UV transmitter technology, ceramic Nd:Y2O3 material is considered to possess great potential. A plasma melting and quenching method has been developed to produce Nd3+ doped powders for consolidation into Nd:Y2O3 ceramic laser materials. This far-from-equilibrium processing methodology allows higher levels of rare earth doping than can be achieved by equilibrium methods. The method comprises of two main steps: (a) plasma melting and quenching to generate dense, and homogeneous doped metastable powders, (b) pressure assisted consolidation of these powders by hot isostatic pressing to make dense nanocomposite ceramics. Using this process, several 1" x 1" ceramic cylinders have been produced. The infrared transmission of undoped Y2O3 ceramics was as high as approx.75% without anti-reflection coating. In the case of Nd:Y2O3 ceramics infrared transmission values of approx.50% were achieved. Furthermore, Nd:Y2O3 samples with dopant concentrations of up to approx.2 at. % were prepared without significant emission quenching.

Deep intronic GPR143 mutation in a Japanese family with ocular albinism

PubMed Central

Naruto, Takuya; Okamoto, Nobuhiko; Masuda, Kiyoshi; Endo, Takao; Hatsukawa, Yoshikazu; Kohmoto, Tomohiro; Imoto, Issei

2015-01-01

Deep intronic mutations are often ignored as possible causes of human disease. Using whole-exome sequencing, we analysed genomic DNAs of a Japanese family with two male siblings affected by ocular albinism and congenital nystagmus. Although mutations or copy number alterations of coding regions were not identified in candidate genes, the novel intronic mutation c.659-131 T > G within GPR143 intron 5 was identified as hemizygous in affected siblings and as heterozygous in the unaffected mother. This mutation was predicted to create a cryptic splice donor site within intron 5 and activate a cryptic acceptor site at 41nt upstream, causing the insertion into the coding sequence of an out-of-frame 41-bp pseudoexon with a premature stop codon in the aberrant transcript, which was confirmed by minigene experiments. This result expands the mutational spectrum of GPR143 and suggests the utility of next-generation sequencing integrated with in silico and experimental analyses for improving the molecular diagnosis of this disease. PMID:26061757

Difference in dimer conformation between amyloid-β(1-42) and (1-43) proteins: Replica exchange molecular dynamics simulations in water

NASA Astrophysics Data System (ADS)

Yano, Atsushi; Okamoto, Akisumi; Nomura, Kazuya; Higai, Shin'ichi; Kurita, Noriyuki

2014-03-01

We searched stable conformations of amyloid-β (Aβ) dimers composed of Aβ(1-42) or Aβ(1-43) protein in water by replica-exchange molecular dynamics simulations and found that Thr43 of the C-terminal of Aβ(1-43) is hydrogen bonded to Arg5 of the same monomer in the Aβ(1-43) dimer, resulting in its ring-shaped conformation, while Aβ(1-42) has no such hydrogen-bond. This conformation is expected to aggregate more easily into a compact conformation of Aβ fibrils. We also investigated the binding affinity and the specific interactions between Aβ monomers by ab initio fragment molecular orbital calculations to elucidate which Aβ residues contribute to the dimerization.

Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells.

PubMed

Gao, Yuan; Xiao, Fei; Wang, Chenglong; Wang, Chuandong; Cui, Penglei; Zhang, Xiaoling; Chen, Xiaodong

2018-05-09

Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) is essential for the human bone formation, and emerging evidence shows that long non-coding RNAs (lncRNAs) play important roles in hBMSC osteogenic differentiation. MALAT1 is often regarded as a tumor-related lncRNA, but its function in mesenchymal stem cell differentiation remains to be defined. In this study, we aimed to investigate whether MALAT1 regulates Osterix (Osx) expression by sponging miR-143 to promote hBMSC osteogenic differentiation. Firstly, we found that the expression of MALAT1 was much lower in hBMSCs from osteoporosis patients and miR-143 was contrarily higher. In addition, MALAT1 expression increased, and miR-143 decreased when hBMSCs were treated with osteogenic induction. Then, we used short hairpin RNAs to knockdown MALAT1, and the results showed that hBMSC osteogenic differentiation decreased significantly, indicating that MALAT1 is a positive regulator of osteogenic differentiation in hBMSCs. Furthermore, by luciferase assays, we found that MALAT1 could directly bind to miR-143 and negatively regulate its expression. Similarly, miR-143 could directly bind to the target site on the Osx 3'-UTR and then inhibit Osx expression. Knockdown of MALAT1 decreased Osx expression, and co-transfection of miR-143 inhibitor could rescue Osx mRNA expression. While Osx expression was increased in MALAT1-overexpressing hBMSCs, it was reversed by the miR-143 mimics. Moreover, Osx silencing decreased ALP, OCN, and OPN mRNA expression induced by the miR-143 inhibitor. Altogether, our findings suggest that MALAT1 acts to regulate Osx expression through targeting miR-143; thus, it is considered as a positive regulator in hBMSC osteogenic differentiation. © 2018 Wiley Periodicals, Inc.

Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cells

PubMed Central

2011-01-01

Background Xenobiotics represent an environmental stress and as such are a source for antibiotics, including the isoquinoline (IQ) compound IQ-143. Here, we demonstrate the utility of complementary analysis of both host and pathogen datasets in assessing bacterial adaptation to IQ-143, a synthetic analog of the novel type N,C-coupled naphthyl-isoquinoline alkaloid ancisheynine. Results Metabolite measurements, gene expression data and functional assays were combined with metabolic modeling to assess the effects of IQ-143 on Staphylococcus aureus, Staphylococcus epidermidis and human cell lines, as a potential paradigm for novel antibiotics. Genome annotation and PCR validation identified novel enzymes in the primary metabolism of staphylococci. Gene expression response analysis and metabolic modeling demonstrated the adaptation of enzymes to IQ-143, including those not affected by significant gene expression changes. At lower concentrations, IQ-143 was bacteriostatic, and at higher concentrations bactericidal, while the analysis suggested that the mode of action was a direct interference in nucleotide and energy metabolism. Experiments in human cell lines supported the conclusions from pathway modeling and found that IQ-143 had low cytotoxicity. Conclusions The data suggest that IQ-143 is a promising lead compound for antibiotic therapy against staphylococci. The combination of gene expression and metabolite analyses with in silico modeling of metabolite pathways allowed us to study metabolic adaptations in detail and can be used for the evaluation of metabolic effects of other xenobiotics. PMID:21418624

The Variable Fast Soft X-Ray Wind in PG 1211+143

NASA Astrophysics Data System (ADS)

Reeves, J. N.; Lobban, A.; Pounds, K. A.

2018-02-01

The analysis of a series of seven observations of the nearby (z = 0.0809) QSO PG 1211+143, taken with the Reflection Grating Spectrometer (RGS) onboard XMM-Newton in 2014, are presented. The high-resolution soft X-ray spectrum, with a total exposure exceeding 600 ks, shows a series of blueshifted absorption lines from the He and H-like transitions of N, O, and Ne, as well as from L-shell Fe. The strongest absorption lines are all systematically blueshifted by ‑0.06c, originating in two absorption zones from low- and high-ionization gas. Both zones are variable on timescales of days, with the variations in absorber opacity effectively explained by either column density changes or the absorber ionization responding directly to the continuum flux. We find that the soft X-ray absorbers probably exist in a two-phase wind at a radial distance of ∼1017–1018 cm from the black hole with the lower-ionization gas as denser clumps embedded within a higher-ionization outflow. The overall mass outflow rate of the soft X-ray wind may be as high as 2{M}ȯ yr‑1, close to the Eddington rate for PG 1211+143 and similar to that previously deduced from the Fe K absorption.

Influence of neodymium concentration on excitation and emission properties of Nd doped gallium oxide nanocrystalline films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Podhorodecki, A.; Banski, M.; Misiewicz, J.

Gallium oxide and more particularly {beta}-Ga{sub 2}O{sub 3} matrix is an excellent material for new generation of devices electrically or optically driven as it is known as the widest band gap transparent conductive oxide. In this paper, the optical properties of neodymium doped gallium oxide films grown by magnetron sputtering have been analyzed. The influence of the Nd ions concentration on the excitation/emission mechanisms of Nd ions and the role of gallium oxide matrix have been investigated. The grain size reduction into gallium oxide films have been observed when concentration of Nd increases. It has been found for all samplesmore » that the charge transfer is the main excitation mechanism for Nd ions where defect states play an important role as intermediate states. As a consequence Nd emission efficiency increases with temperature giving rise to most intensive emission at 1087 nm at room temperature.« less

Coherent response of Antarctic Intermediate Water and Atlantic Meridional Overturning Circulation during the last deglaciation: reconciling contrasting neodymium isotope reconstructions in tropical Atlantic

NASA Astrophysics Data System (ADS)

Gu, S.; Liu, Z.; Zhang, J.; Rempfer, J.; Joos, F.; Oppo, D.

2017-12-01

Antarctic Intermediate Water (AAIW) plays important roles in the global climate system and the global ocean nutrient and carbon cycles. However, it is unclear how AAIW responds to global climate changes. In particular, neodymium isotopic composition (ɛNd) reconstructions from different locations in tropical Atlantic, have led to a debate on the relationship between the northward penetration of AAIW into the tropical Atlantic and Atlantic Meridional Overturning Circulation (AMOC) variability during the last deglaciation. We resolve this controversy by studying the transient oceanic evolution during the last deglaciation using a neodymium-enabled ocean model. Our results suggest a coherent response of AAIW and AMOC: when AMOC weakens, the northward penetration and transport of AAIW decreases while its depth and thickness increase. Our study highlights that as part of the return flow of the North Atlantic Deep Water (NADW), the northward penetration of AAIW in Atlantic is determined predominately by AMOC intensity. Moreover, the inconsistency among different tropical Atlantic ɛNd reconstructions is reconciled by considering their corresponding core locations and depths, which were influenced by different water masses and ocean currents in the past. The very radiogenic water from the bottom of the Gulf of Mexico and Caribbean Sea, which was previously overlooked in interpretations of deglacial ɛNd variability, can be transported to shallow layers during active AMOC, and modulates ɛNd in the tropical Atlantic. Changes in the AAIW core depth must also be considered. Thus, interpretation of ɛNd reconstructions from the tropical Atlantic is more complicated than suggested in previous studies. ­­

Value analysis of neodymium content in shredder feed: toward enabling the feasibility of rare earth magnet recycling.

PubMed

Bandara, H M Dhammika; Darcy, Julia W; Apelian, Diran; Emmert, Marion H

2014-06-17

In order to facilitate the development of recycling technologies for rare earth magnets from postconsumer products, we present herein an analysis of the neodymium (Nd) content in shredder scrap. This waste stream has been chosen on the basis of current business practices for the recycling of steel, aluminum, and copper from cars and household appliances, which contain significant amounts of rare earth magnets. Using approximations based on literature data, we have calculated the average Nd content in the ferrous shredder product stream to be between 0.13 and 0.29 kg per ton of ferrous scrap. A value analysis considering rare earth metal prices between 2002 and 2013 provides values between $1.32 and $145 per ton of ferrous scrap for this material, if recoverable as pure Nd metal. Furthermore, we present an analysis of the content and value of other rare earths (Pr, Dy, Tb).

Optical radiation hazards of laser welding processes. Part 1: Neodymium-YAG laser.

PubMed

Rockwell, R J; Moss, C E

1983-08-01

High power laser devices are being used for numerous metalworking processes such as welding, cutting and heat treating. Such laser devices are totally enclosed either by the manufacturer or the end-user. When this is done, the total laser system is usually certified by the manufacturer following the federal requirements of the Code of Federal Regulations (CFR) 1040.10 and 10.40.11 as a Class I laser system. Similarly, the end-user may also reclassify an enclosed high-power laser into the Class I category following the requirements of the American National Standards Institute (ANSI) Z-136.1 (1980) standard. There are, however, numerous industrial laser applications where Class IV systems are required to be used in an unenclosed manner. In such applications, there is concern for both ocular and skin hazards caused by direct and scattered laser radiation, as well as potential hazards caused by the optical radiation created by the laser beam's interaction with the metal (i.e. the plume radiation). Radiant energy measurements are reported for both the scattered laser radiation and the resultant plume radiations which were produced during typical unenclosed Class IV Neodymium-YAG laser welding processes. Evaluation of the plume radiation was done with both radiometric and spectroradiometric measurement equipment. The data obtained were compared to applicable safety standards.

40 CFR 429.143 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS TIMBER PRODUCTS PROCESSING POINT SOURCE CATEGORY Particleboard Manufacturing Subcategory § 429.143 Effluent limitations representing the degree of effluent reduction...

Neodymium(III) Complexes of Dialkylphosphoric and Dialkylphosphonic Acids Relevant to Liquid-Liquid Extraction Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lumetta, Gregg J.; Sinkov, Sergey I.; Krause, Jeanette A.

2016-01-27

The complexes formed during the extraction of neodymium(III) into hydrophobic solvents containing acidic organophosphorus extractants were probed by single-crystal X-ray diffractometry, visible spectrophotometry, and Fourier-transform infrared spectroscopy. The crystal structure of the compound Nd(DMP)3 (1, DMP = dimethyl phosphate) revealed a polymeric arrangement in which each Nd(III) center is surrounded by six DMP oxygen atoms in a pseudo-octahedral environment. Adjacent Nd(III) ions are bridged by (MeO)2POO– anions, forming the polymeric network. The diffuse reflectance visible spectrum of 1 is nearly identical to that of the solid that is formed when an n-dodecane solution of di-(2-ethylhexyl)phosphoric acid (HA) is saturated withmore » Nd(III), indicating a similar coordination environment around the Nd center in the NdA3 solid. The visible spectrum of the HA solution fully loaded with Nd(III) is very similar to that of the NdA3 material, both displaying hypersensitive bands characteristic of an pseudo-octahedral coordination environment around Nd. These spectral characteristics persisted across a wide range of organic Nd concentrations, suggesting that the pseudo-octahedral coordination environment is maintained from dilute to saturated conditions.« less

Neodymium(III) Complexes of Dialkylphosphoric and Dialkylphosphonic Acids Relevant to Liquid-Liquid Extraction Systems.

PubMed

Lumetta, Gregg J; Sinkov, Sergey I; Krause, Jeanette A; Sweet, Lucas E

2016-02-15

The complexes formed during the extraction of neodymium(III) into hydrophobic solvents containing acidic organophosphorus extractants were probed by single-crystal X-ray diffractometry, visible spectrophotometry, and Fourier-transform infrared spectroscopy. The crystal structure of the compound Nd(DMP)3 (1, DMP = dimethyl phosphate) revealed a polymeric arrangement in which each Nd(III) center is surrounded by six DMP oxygen atoms in a pseudo-octahedral environment. Adjacent Nd(III) ions are bridged by (MeO)2POO(-) anions, forming the polymeric network. The diffuse reflectance visible spectrum of 1 is nearly identical to that of the solid that is formed when an n-dodecane solution of di(2-ethylhexyl)phosphoric acid (HA) is saturated with Nd(III), indicating a similar coordination environment around the Nd center in the NdA3 solid. The visible spectrum of the HA solution fully loaded with Nd(III) is very similar to that of the NdA3 material, both displaying hypersensitive bands characteristic of an pseudo-octahedral coordination environment around Nd. These spectral characteristics persisted across a wide range of organic Nd concentrations, suggesting that the pseudo-octahedral coordination environment is maintained from dilute to saturated conditions.

Early onset of magma ocean crystallization revealed by coupled 146,147Sm-142,143Nd systematics of Nulliak ultramafics (3.78 Ga, Labrador)

NASA Astrophysics Data System (ADS)

Morino, P.; Caro, G.; Reisberg, L. C.

2015-12-01

Early onset of magma ocean crystallization revealed by coupled 146,147Sm-142,143Nd systematics of Nulliak ultramafics (3.78 Ga, Labrador) Precillia Morino1, Guillaume Caro1, Laurie Reisberg 1 1CRPG-CNRS, Université de Lorraine, Nancy, France Coupled 146,147Sm-142,143Nd systematics provides constraints on the timing of magma ocean crystallization on Mars, the Moon and Vesta. Estimates for the Earth's mantle, however, are less accurate owing to the sparsity of Eoarchean mantle-derived rocks with undisturbed 147Sm-143Nd systematics. This study attempts to establish a coherent 142,143Nd dataset for the Eoarchean mantle using well-preserved ultramafic rocks from the Nulliak assemblage (Labrador). Samples include meta-dunites, -pyroxenites and -peridotites exhibiting only minor serpentinization and limited element mobility. The presence of "Barberton type" komatiitic compositions (low Al/Ti, HREE depletion) is suggestive of a deep mantle source. 146,147Sm-142,143Nd and 187Re-187Os analyses yield a crystallization age of 3.78±0.09 Ga with ɛ143Ndi=1.5±0.2 and ɛ142Nd=8.6±2 ppm. This 142,143Nd signature yields a model age of mantle differentiation of 4.43±0.05 Ga (assuming a BSE with chondritic Sm/Nd and ɛ142Nd=0). Superchondritic Sm/Nd compositions for the BSE would translate into older model ages. Irrespective of the choice of primitive mantle composition, Nulliak ultramafics provide differentiation ages 100 Ma older than those estimated from Akilia tonalites but remarkably similar to that estimated from the 2.7 Ga Theo's flow (Abitibi). If Nulliak ultramafics originated from deep melting of a hot plume, their model age could reflect the early onset of magma ocean crystallization in the lowermost mantle.

A randomized controlled trial of peeling and aspiration of Elschnig pearls and neodymium: yttrium-aluminium-garnet laser capsulotomy.

PubMed

Bhargava, Rahul; Kumar, Prachi; Sharma, Shiv Kumar; Kaur, Avinash

2015-01-01

To compare surgical peeling and aspiration and neodymium yttrium garnet laser capsulotomy for pearl form of posterior capsule opacification (PCO). A prospective, randomized, double blind, study was done at Rotary Eye Hospital, Maranda, Palampur, India, Santosh Medical College Hospital, Ghaziabad, India and Laser Eye Clinic, Noida India. Consecutive patients with pearl form of PCO following surgery, phacoemulsification, manual small incision cataract surgery and conventional extracapsular cataract extraction (ECCE) for age related cataract, were randomized to have peeling and aspiration or neodymium yttrium garnet laser capsulotomy. Corrected distance visual acuity (CDVA), intra-operative and post-operative complications were compared. A total of 634 patients participated in the study, and 314 (49.5%) patients were randomized to surgical peeling and aspiration group and 320 (50.5%) to the Nd:YAG laser group. The mean pre-procedural logMAR CDVA in peeling and neodymium: yttrium-aluminium-garnet (Nd:YAG) laser group was 0.80±0.25 and 0.86±0.22, respectively. The mean final CDVA in peeling group (0.22±0.23) was comparable to Nd:YAG group (0.24±0.28; t test, P=0.240). There was a significant improvement in vision after both the procedures (P<0.001). A slightly higher percentage of patients in Nd:YAG laser group (283/88.3%) than in peeling group (262/83.4%) had a CDVA of 0.5 (20/63) or better at 9mo (P<0.001). On the contrary, patients having CDVA worse than 1.00 (20/200) was also significantly higher in Nd:YAG laser group as compared to peeling group (25/7.7% vs 15/4.7%, respectively). On application of ANCOVA, there was less than 0.001% risk that PCO thickness and total laser energy had no effect on rate of complications in Nd:YAG laser group and less than 0.001 % risk that PCO thickness had no effect on complications in peeling group respectively. Sum of square analysis suggests that in the Nd:YAG laser group, thick PCO had a stronger impact on complications

A randomized controlled trial of peeling and aspiration of Elschnig pearls and neodymium: yttrium-aluminium-garnet laser capsulotomy

PubMed Central

Bhargava, Rahul; Kumar, Prachi; Sharma, Shiv Kumar; Kaur, Avinash

2015-01-01

AIM To compare surgical peeling and aspiration and neodymium yttrium garnet laser capsulotomy for pearl form of posterior capsule opacification (PCO). METHODS A prospective, randomized, double blind, study was done at Rotary Eye Hospital, Maranda, Palampur, India, Santosh Medical College Hospital, Ghaziabad, India and Laser Eye Clinic, Noida India. Consecutive patients with pearl form of PCO following surgery, phacoemulsification, manual small incision cataract surgery and conventional extracapsular cataract extraction (ECCE) for age related cataract, were randomized to have peeling and aspiration or neodymium yttrium garnet laser capsulotomy. Corrected distance visual acuity (CDVA), intra-operative and post-operative complications were compared. RESULTS A total of 634 patients participated in the study, and 314 (49.5%) patients were randomized to surgical peeling and aspiration group and 320 (50.5%) to the Nd:YAG laser group. The mean pre-procedural logMAR CDVA in peeling and neodymium: yttrium-aluminium-garnet (Nd:YAG) laser group was 0.80±0.25 and 0.86±0.22, respectively. The mean final CDVA in peeling group (0.22±0.23) was comparable to Nd:YAG group (0.24±0.28; t test, P=0.240). There was a significant improvement in vision after both the procedures (P<0.001). A slightly higher percentage of patients in Nd:YAG laser group (283/88.3%) than in peeling group (262/83.4%) had a CDVA of 0.5 (20/63) or better at 9mo (P<0.001). On the contrary, patients having CDVA worse than 1.00 (20/200) was also significantly higher in Nd:YAG laser group as compared to peeling group (25/7.7% vs 15/4.7%, respectively). On application of ANCOVA, there was less than 0.001% risk that PCO thickness and total laser energy had no effect on rate of complications in Nd:YAG laser group and less than 0.001 % risk that PCO thickness had no effect on complications in peeling group respectively. Sum of square analysis suggests that in the Nd:YAG laser group, thick PCO had a stronger impact on

Cumulative probability of neodymium: YAG laser posterior capsulotomy after phacoemulsification.

PubMed

Ando, Hiroshi; Ando, Nobuyo; Oshika, Tetsuro

2003-11-01

To retrospectively analyze the cumulative probability of neodymium:YAG (Nd:YAG) laser posterior capsulotomy after phacoemulsification and to evaluate the risk factors. Ando Eye Clinic, Kanagawa, Japan. In 3997 eyes that had phacoemulsification with an intact continuous curvilinear capsulorhexis, the cumulative probability of posterior capsulotomy was computed by Kaplan-Meier survival analysis and risk factors were analyzed using the Cox proportional hazards regression model. The variables tested were sex; age; type of cataract; preoperative best corrected visual acuity (BCVA); presence of diabetes mellitus, diabetic retinopathy, or retinitis pigmentosa; type of intraocular lens (IOL); and the year the operation was performed. The IOLs were categorized as 3-piece poly(methyl methacrylate) (PMMA), 1-piece PMMA, 3-piece silicone, and acrylic foldable. The cumulative probability of capsulotomy after cataract surgery was 1.95%, 18.50%, and 32.70% at 1, 3, and 5 years, respectively. Positive risk factors included a better preoperative BCVA (P =.0005; risk ratio [RR], 1.7; 95% confidence interval [CI], 1.3-2.5) and the presence of retinitis pigmentosa (P<.0001; RR, 6.6; 95% CI, 3.7-11.6). Women had a significantly greater probability of Nd:YAG laser posterior capsulotomy (P =.016; RR, 1.4; 95% CI, 1.1-1.8). The type of IOL was significantly related to the probability of Nd:YAG laser capsulotomy, with the foldable acrylic IOL having a significantly lower probability of capsulotomy. The 1-piece PMMA IOL had a significantly higher risk than 3-piece PMMA and 3-piece silicone IOLs. The probability of Nd:YAG laser capsulotomy was higher in women, in eyes with a better preoperative BCVA, and in patients with retinitis pigmentosa. The foldable acrylic IOL had a significantly lower probability of capsulotomy.

Cataracts induced by neodymium-yttrium-aluminium-garnet laser lysis of vitreous floaters.

PubMed

Koo, Ellen H; Haddock, Luis J; Bhardwaj, Namita; Fortun, Jorge A

2017-06-01

Neodymium-yttrium-aluminium-garnet (Nd:YAG) laser vitreolysis has been proposed as a treatment modality for symptomatic vitreous floaters. The purpose of this paper is to report two cases of cataracts associated with posterior capsular compromise, induced by Nd:YAG laser vitreolysis for symptomatic vitreous floaters. Case series. Two patients who underwent ND:YAG laser vitreolysis for symptomatic floaters, presented with decline in visual acuity in the treated eye after the laser procedure. At the slit-lamp biomicroscope, each patient was found to have a posterior subcapsular cataract in the treated eye, with obvious loss of integrity of the posterior capsule. These two patients underwent cataract extraction by the same surgeon via phacoemulsification. Both eyes were found to have a defect in the posterior capsule intraoperatively. In both cases, a three-piece acrylic intraocular lens implant was placed in the sulcus, achieving optic capture. The best-corrected visual acuity (BCVA) was 20/20 in both patients, at 1 month following the surgery. At 2 months, one patient had a BCVA of 20/15. The second patient maintained a BCVA of 20/20 at 3 months. Secondary cataract formation accompanied by loss of integrity of the posterior capsule is a potential complication of Nd:YAG laser vitreolysis for symptomatic floaters. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

[Two-photon up-conversion fluorescence of a neodymium organic framework Nd(BTC)].

PubMed

Xu, Hui; Jin, Run-zhi; Wu, Chun-yang; Yang, Yu; Qian, Guo-dong

2008-08-01

In the present work, a neodymium organic framework Nd(BTC) was synthesized by the solvothermal reaction of Nd(NO3)3 x 5H2O and H3BTC (BTC = 1,3,5-benzenetricarboxylate) in mixed solvents of DMF, ethanol and water, and was identified by elemental analysis. This MOF complex was characterized using X-ray diffraction (XRD), thermogravimetry-differential scanning calorimetry (TGA-DSC) analysis, UV-visible absorption spectra and fluorescence spectra. This polycrystalline powder lost DMF and H2O when heated to 120 degrees C, then remained stable till the temperature reached 500 degrees C. Near infrared fluorescence at 1064 nm due to the 4 F3/2--> 4 I11/2 transition of Nd3+ ions was exhibited when excited by 808 nm laser beam. It was also been found that up-conversion fluorescence of Nd(BTC) peaked at about 450 nm due to 2 D5/2 -->4 I11/2 transition of Nd3+ ions can be observed under the excitation of a 580 nm laser line. The mechanism of the up-conversion fluorescence of Nd(BTC) at around 450 nm under the excitation of 580 nm laser can be ascribed to both excited-state absorption and energy transfer up-conversion. This result indicated that such MOF can be employed as an up-conversion luminescence material in many potential application areas such as bio-labeling and fluorescence image.

Neodymium isotope evolution of NW Tethyan upper ocean waters throughout the Cretaceous

NASA Astrophysics Data System (ADS)

Pucéat, Emmanuelle; Lécuyer, Christophe; Reisberg, Laurie

2005-08-01

Neodymium isotope compositions of twenty-four fish teeth, nineteen from the NW Tethys and five from different locations within the Tethys, are interpreted to reflect the evolution of Tethyan upper ocean water composition during the Cretaceous and used to track changes in erosional inputs to the NW Tethys and in oceanic circulation throughout the Cretaceous. The rather high ɛNd (up to - 7.6) of the NW Tethyan upper ocean waters recorded from the Late Berriasian to the Early Aptian and the absence of negative excursions during this interval support the presence of a permanent westward flowing Tethys Circumglobal Current (TCC). This implies that temperature variations during this time period, inferred from the oxygen isotope analysis of fish tooth enamel, were not driven by changes in surface oceanic currents, but rather by global climatic changes. The results presented here represent a significant advance over previously published Cretaceous seawater Nd isotope records. Our newly acquired data now allow the identification of two stages of low ɛNd values in the NW Tethys, during the Early Albian-Middle Albian interval (down to - 10) and the Santonian-Early Campanian (down to - 11.4), which alternate with two stages of higher ɛNd values (up to - 9) during the Late Albian-Turonian interval and the Maastrichtian. Used in conjunction with the oxygen isotope record, the fluctuations of ɛNd values can be related to major climatic, oceanographic, and tectonic events that appeared in the western Tethyan domain.

Effect of Partial Substitution of Neodymium with Praseodymium on the Magnetic and Process Properties of Sintered Magnets of Type NdFeB

NASA Astrophysics Data System (ADS)

Dormidontov, N. A.; Dormidontov, A. G.; Lileev, A. S.; Kamynin, A. V.; Lukin, A. A.

2017-01-01

The effect of substitution of neodymium with praseodymium in sintered magnets of type NdFeB on their magnetic and process properties in the concentration range of [Pr] = 0 - 13 wt.% is studied. The special features of milling of the alloys, sintering processes and heat treatments in the production of magnets containing praseodymium are discussed. Hysteresis characteristics of B r ≥ 1.2 T, H cJ ≥ 1200 kA/m, H cb ≥ 880 kA/m, H k ≥ 960 kA/m, and BH max ≥ 280 kJ/m3 are obtained for magnets with composition (in wt.%) 33 Nd, 10 Pr, 1.5 (Ti + Al + Cu), 1.3 B, the remainder Fe.

Commentary: Is There Clinical Benefit From Using a Diode or Neodymium:Yttrium-Aluminum-Garnet Laser in the Treatment of Periodontitis?

PubMed

Cobb, Charles M

2016-10-01

Despite a quarter of a century of laser research, there is a persistent debate regarding the efficacy of dental lasers in the treatment of periodontitis or periodontal maintenance therapy. There are many claims and much hyperbole surrounding the use of lasers, either as a monotherapy or adjunctive to scaling and root planing, to treat periodontitis. There is little evidence that using a diode or neodymium:yttrium-aluminum-garnet laser adds clinical value over and above conventional non-surgical or surgical periodontal treatment. There is a significant need for better designed human clinical trials. Data from such trials should be analyzed according to initial probing depth and characteristics of the treated sites, such as non-molar, molar flat surfaces, and molar furcations, and evaluated for long-term post-treatment results.

X-ray spectrum and variability of the quasar PG 1211+143

NASA Technical Reports Server (NTRS)

Yaqoob, Tahir; Serlemitsos, Peter; Mushotzky, Richard; Madejski, Greg; Turner, T. Jane; Kunieda, Hideyo

1994-01-01

We present preliminary results of an ASCA observation of the classic soft-excess quasar PG 1211+143. The overall ASCA spectrum can be characterized by a blackbody with a temperature of approximately 125 eV (quasar frame) and a power law with photon index of approximately 2. Simultaneous ROSAT data are suggestive of further steepening of the spectrum just below the ASCA band. Comparison with previous observations shows that the soft flux in the 0.1-2 keV band varies by at least a factor of approximately 16, scaling roughly as the square of the hard flux in the 2-10 keV band over a timescale of approximately 13.5 yr. We also find evidence of short-term amplitude variability of up to a factor of approximately 2 on a timescale of approximately 2 x 10(exp 4) sec, in both the soft and hard flux so that the soft and hard photons are likely to originate from the same, compact, region. The data rule out variable absorption (cold or ionized) as the origin of the soft excess, favoring an intrinsic emission component. However, we argue against optically thin emission for the 'blue bump' in PG 1211+143. The large amplitude soft X-ray variability may be indicative of variations in the effective temperature, or peak, of the soft component. There is only marginal evidence for Fe K line emission between 6-7 keV in the quasar frame.

Twisted light transmission over 143 km

PubMed Central

Krenn, Mario; Handsteiner, Johannes; Fink, Matthias; Fickler, Robert; Ursin, Rupert; Zeilinger, Anton

2016-01-01

Spatial modes of light can potentially carry a vast amount of information, making them promising candidates for both classical and quantum communication. However, the distribution of such modes over large distances remains difficult. Intermodal coupling complicates their use with common fibers, whereas free-space transmission is thought to be strongly influenced by atmospheric turbulence. Here, we show the transmission of orbital angular momentum modes of light over a distance of 143 km between two Canary Islands, which is 50× greater than the maximum distance achieved previously. As a demonstration of the transmission quality, we use superpositions of these modes to encode a short message. At the receiver, an artificial neural network is used for distinguishing between the different twisted light superpositions. The algorithm is able to identify different mode superpositions with an accuracy of more than 80% up to the third mode order and decode the transmitted message with an error rate of 8.33%. Using our data, we estimate that the distribution of orbital angular momentum entanglement over more than 100 km of free space is feasible. Moreover, the quality of our free-space link can be further improved by the use of state-of-the-art adaptive optics systems. PMID:27856744

Twisted light transmission over 143 km

NASA Astrophysics Data System (ADS)

Krenn, Mario; Handsteiner, Johannes; Fink, Matthias; Fickler, Robert; Ursin, Rupert; Malik, Mehul; Zeilinger, Anton

2016-11-01

Spatial modes of light can potentially carry a vast amount of information, making them promising candidates for both classical and quantum communication. However, the distribution of such modes over large distances remains difficult. Intermodal coupling complicates their use with common fibers, whereas free-space transmission is thought to be strongly influenced by atmospheric turbulence. Here, we show the transmission of orbital angular momentum modes of light over a distance of 143 km between two Canary Islands, which is 50× greater than the maximum distance achieved previously. As a demonstration of the transmission quality, we use superpositions of these modes to encode a short message. At the receiver, an artificial neural network is used for distinguishing between the different twisted light superpositions. The algorithm is able to identify different mode superpositions with an accuracy of more than 80% up to the third mode order and decode the transmitted message with an error rate of 8.33%. Using our data, we estimate that the distribution of orbital angular momentum entanglement over more than 100 km of free space is feasible. Moreover, the quality of our free-space link can be further improved by the use of state-of-the-art adaptive optics systems.

Twisted light transmission over 143 km.

PubMed

Krenn, Mario; Handsteiner, Johannes; Fink, Matthias; Fickler, Robert; Ursin, Rupert; Malik, Mehul; Zeilinger, Anton

2016-11-29

Spatial modes of light can potentially carry a vast amount of information, making them promising candidates for both classical and quantum communication. However, the distribution of such modes over large distances remains difficult. Intermodal coupling complicates their use with common fibers, whereas free-space transmission is thought to be strongly influenced by atmospheric turbulence. Here, we show the transmission of orbital angular momentum modes of light over a distance of 143 km between two Canary Islands, which is 50× greater than the maximum distance achieved previously. As a demonstration of the transmission quality, we use superpositions of these modes to encode a short message. At the receiver, an artificial neural network is used for distinguishing between the different twisted light superpositions. The algorithm is able to identify different mode superpositions with an accuracy of more than 80% up to the third mode order and decode the transmitted message with an error rate of 8.33%. Using our data, we estimate that the distribution of orbital angular momentum entanglement over more than 100 km of free space is feasible. Moreover, the quality of our free-space link can be further improved by the use of state-of-the-art adaptive optics systems.

Constraints on ocean circulation at the Paleocene-Eocene Thermal Maximum from neodymium isotopes

NASA Astrophysics Data System (ADS)

Abbott, April N.; Haley, Brian A.; Tripati, Aradhna K.; Frank, Martin

2016-04-01

Global warming during the Paleocene-Eocene Thermal Maximum (PETM) ˜ 55 million years ago (Ma) coincided with a massive release of carbon to the ocean-atmosphere system, as indicated by carbon isotopic data. Previous studies have argued for a role of changing ocean circulation, possibly as a trigger or response to climatic changes. We use neodymium (Nd) isotopic data to reconstruct short high-resolution records of deep-water circulation across the PETM. These records are derived by reductively leaching sediments from seven globally distributed sites to reconstruct past deep-ocean circulation across the PETM. The Nd data for the leachates are interpreted to be consistent with previous studies that have used fish teeth Nd isotopes and benthic foraminiferal δ13C to constrain regions of convection. There is some evidence from combining Nd isotope and δ13C records that the three major ocean basins may not have had substantial exchanges of deep waters. If the isotopic data are interpreted within this framework, then the observed pattern may be explained if the strength of overturning in each basin varied distinctly over the PETM, resulting in differences in deep-water aging gradients between basins. Results are consistent with published interpretations from proxy data and model simulations that suggest modulation of overturning circulation had an important role for initiation and recovery of the ocean-atmosphere system associated with the PETM.

25 CFR 170.143 - How can IRR Program funds be used for highway safety?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false How can IRR Program funds be used for highway safety? 170... RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Highway Safety Functions § 170.143 How can IRR Program funds be used for highway safety? A tribe, tribal organization, tribal...

25 CFR 170.143 - How can IRR Program funds be used for highway safety?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false How can IRR Program funds be used for highway safety? 170... RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Highway Safety Functions § 170.143 How can IRR Program funds be used for highway safety? A tribe, tribal organization, tribal...

25 CFR 170.143 - How can IRR Program funds be used for highway safety?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true How can IRR Program funds be used for highway safety? 170... RESERVATION ROADS PROGRAM Indian Reservation Roads Program Policy and Eligibility Highway Safety Functions § 170.143 How can IRR Program funds be used for highway safety? A tribe, tribal organization, tribal...