Sample records for neurostimulation forty years

  1. Forty years of antiprotons

    Microsoft Academic Search

    J. Eades; F. J. Hartmann

    1999-01-01

    The discovery of the antiproton some 40 years ago and the almost synchronous fall of parity (P) and charge conjugation (C) symmetries were soon followed by the realization that CPT rather than C invariance is the fundamental symmetry connecting matter and antimatter, and that consequently any measurement of the antiproton's properties can be interpreted as a test of that symmetry.

  2. Richard Serra Sculpture: Forty Years

    NSDL National Science Digital Library

    2007-01-01

    Richard Serra�s work has usually involved very large sculptures, and many of them have tested the limits of museum display techniques. Recently, the Museum of Modern Art mounted a forty-year survey of Serra�s work, and for those who can�t make it to New York, this online collection is a nice way to look at some of the pieces featured at the museum.

  3. Forty years of TTG research

    NASA Astrophysics Data System (ADS)

    Moyen, Jean-François; Martin, Hervé

    2012-09-01

    TTGs (tonalite-trondhjemite-granodiorite) are one of the archetypical lithologies of Archaean cratons. Since their original description in the 1970s, they have been the subject of many studies and discussions relating to Archaean geology. In this paper, we review the ideas, concepts and arguments brought forward in these 40 years, and try to address some open questions — both old and new. The late 1960s and the 1970s mark the appearance of "grey gneisses" (TTG) in the scientific literature. During this period, most work was focused on the identification and description of this suite, and the recognition that it is a typical Archaean lithology. TTGs were already recognised as generated by melting of mafic rocks. This was corroborated during the next decade, when detailed geochemical TTG studies allowed us to constrain their petrogenesis (melting of garnet-bearing metamafic rocks), and to conclude that they must have been generated by Archaean geodynamic processes distinct from their modern counterparts. However, the geodynamic debate raged for the following 30 years, as many distinct tectonic scenarios can be imagined, all resulting in the melting of mafic rocks in the garnet stability field. The 1990s were dominated by experimental petrology work. A wealth of independent studies demonstrated that melting of amphibolites as well as of mafic eclogites can give rise to TTG liquids; whether amphibolitic or eclogitic conditions are more likely is still an ongoing debate. From 1990s onwards, one of the key questions became the comparison with modern adakites. As originally defined these arc lavas are reasonably close equivalents to Archaean TTGs. Pending issues largely revolve around definitions, as the name TTG has now been applied to most Archaean plutonic rocks, whether sodic or potassic, irrespective of their HREE contents. This leads to a large range of petrogenetic and tectonic scenarios; a fair number of which may well have operated concurrently, but are applicable only to some of the rocks lumped together in the ever-broadening TTG "bin".

  4. Forty years of canine vaccination.

    PubMed

    Appel, M J

    1999-01-01

    During the last 40 years vaccines have been developed that have greatly reduced the incidence of infectious diseases of dogs. In general, modified live products have been superior to inactivated vaccines for dogs. It can be expected that recombinant and/or DNA vaccines may dominate the market in the future. Although most vaccines on the market are safe and efficacious, there have been exceptions where disease was induced by vaccination or dogs were not protected. The failure of protection may in part be due to variations in individual vaccine batches. Only potency tests but not efficacy tests are required, which may not be sufficient. For example, a virus titer in a vaccine may be meaningless if the minimum protective dose is not known. Overattenuated virus (e.g., CDV-Ond or parvovirus in cat cells) may have a high titer in tissue culture but is not immunogenic. The question of frequency of vaccination of dogs should be addressed. Annual revaccinations for CDV, CPV, and CAV are probably not needed. However, it would be desirable to collect more data to support less frequent vaccinations. Annual immunization for bacterial diseases such as kennel cough, Lyme disease, and leptospirosis should continue. It also would be desirable to develop more oro/nasal vaccines, perhaps combined with newly developed vectors that are less likely to induce undesirable side effects that may be seen after parenteral vaccination. Finally a word of warning against homeopathic "nosodes" to replace tested canine vaccines. They will appear highly effective as long as the majority of dogs remain vaccinated. As soon as a nonvaccinated dog population is large enough to allow virulent agents to spread, disease outbreaks will occur and we will be back where we began 40 years ago. PMID:9890024

  5. The first forty years, 1947-1987

    SciTech Connect

    Rowe, M.S. (ed.); Cohen, A.; Petersen, B.

    1987-01-01

    This report commemorates the fortieth anniversary of Brookhaven National Laboratory by representing a historical overview of research at the facility. The chapters of the report are entitled: The First Forty Years, Brookhaven: A National Resource, Fulfilling a Mission - Brookhaven's Mighty Machines, Marketing the Milestones in Basic Research, Meeting National Needs, Making a Difference in Everyday Life, and Looking Forward.

  6. The Forties field: 20 years young

    SciTech Connect

    Brand, P.J.; Clyne, P.A.; Kirkwood, F.G.; Williams, P.W. [BP Exploration Co. Ltd., Aberdeen (United Kingdom)

    1996-04-01

    In Oct. 1970, BP`s semisubmersible drilling rig SeaQuest struck oil in Upper Paleocene (Tertiary) sandstones of U.K. Continental Shelf Block 21/10. Four appraisal wells drilled in 1970 and 1971 delineated a large oil reservoir at a depth of 7,000 ft., covering an area of 36 sq miles. The maximum thickness of the oil-bearing sandstone was estimated at 614 ft. Reserves were calculated to be 1,800 MMSTB from an oil in place (OIP) of 4,600 MMSTB, and production was projected to continue until Year 2000. In 1971, Shell/Esso drilled a successful well, Well 22/6-1, that demonstrated the southeastern extension of the field into Block 22/6. The field is a four-way-dip-closed anticline that overlies the Forties-Montrose Ridge and is close to the junction of the Central, South Viking, and Witch Ground grabens. The reservoir occurs in thick Upper Paleocene sandstones deposited as a sand-rich submarine fan sequence. This paper describes how the development of the Forties field has evolved over the past 20 years, the current issues and activities, and the direction for the future.

  7. Synthesis of the elements in stars: forty years of progress

    Microsoft Academic Search

    George Wallerstein; Icko Iben Jr.; Peter Parker; Ann Merchant Boesgaard; Gerald M. Hale; Arthur E. Champagne; Charles A. Barnes; Franz Käppeler; Verne V. Smith; Robert D. Hoffman; Frank X. Timmes; Chris Sneden; Richard N. Boyd; Bradley S. Meyer; David L. Lambert

    1997-01-01

    Forty years ago Burbidge, Burbidge, Fowler, and Hoyle combined what we would now call fragmentary evidence from nuclear physics, stellar evolution and the abundances of elements and isotopes in the solar system as well as a few stars into a synthesis of remarkable ingenuity. Their review provided a foundation for forty years of research in all of the aspects of

  8. Forty years of genetic recombination in bacteria

    Microsoft Academic Search

    Joshua Lederberg

    1986-01-01

    Between April and June 1946, Joshua Lederberg and Edward L. Tatum carried out a series of experiments that proved that bacteria can exchange their genes by sexual crossings. The experiments were reported in Nature just 40 years ago1. In the following pair of articles, Joshua Lederberg first provides a personal reminiscence of the circumstances of the discovery and then, together

  9. Forty years of Clar's aromatic ?-sextet rule

    PubMed Central

    Solà, Miquel

    2013-01-01

    In 1972 Erich Clar formulated his aromatic ?-sextet rule that allows discussing qualitatively the aromatic character of benzenoid species. Now, 40 years later, Clar's aromatic ?-sextet rule is still a source of inspiration for many chemists. This simple rule has been validated both experimentally and theoretically. In this review, we select some particular examples to highlight the achievement of Clar's aromatic ?-sextet rule in many situations and we discuss two recent successful cases of its application. PMID:24790950

  10. Nuclear chain reaction: forty years later

    SciTech Connect

    Sachs, R.G. (ed.)

    1984-01-01

    The proceedings from a 1982 symposium 40 years after the first controlled nuclear chain reaction took place in Chicago covers four sessions and public discussion. The session covered the history of the chain reaction; peaceful uses in technology, medicine, and biological science; peaceful uses in power generation; and nuclear weapons control. Among the speakers were Eugene Wigner, Glenn Seaborg, Alvin Weinberg, and others who participated in the first chain reaction experiments. The proceedings reflect differences of opinion among the scientists as well as the general public. References, slides, and tables used to illustrate the individual talks are included with the papers.

  11. Reconstructing Forty Years of Landsat Observations

    NASA Astrophysics Data System (ADS)

    Meyer, D. J.; Dwyer, J. L.; Steinwand, D.

    2013-12-01

    In July 1972, NASA launched the Earth Resource Technology Satellite (ERTS), the first of what was to be the series of Earth-observing satellites we now know as the Landsat system. This system, originally conceived in the 1960's within the US Department of the Interior and US Geological Survey (USGS), has continued with little interruption for over 40 years, creating the longest record of satellite-based global land observations. The current USGS archive of Landsat images exceeds 4 million scenes, and the recently launched Landsat 8 platform will extend that archive to nearly 50 years of observations. Clearly, these observations are critical to the study of Earth system processes, and the interaction between these processes and human activities. However, the seven successful Landsat missions represent more of an ad hoc program than a long-term record of consistent observations, due largely to changing Federal policies and challenges finding an operational home for the program. Technologically, these systems evolved from the original Multispectral Scanning System (MSS) through the Thematic Mapper and Enhanced Thematic Mapper Plus (ETM+) systems, to the current Observational Land Imager (OLI) and Thermal Infrared Sensor (TIRS) systems. Landsat data were collected globally by a network of international cooperators having diverse data management policies. Much of the oldest data were stored on archaic media that could not be retrieved using modern media readers. Collecting these data from various sensors and sources, and reconstructing them into coherent Earth observation records, posed numerous challenges. We present here a brief overview of work done to overcome these challenges and create a consistent, long-term Landsat observation record. Much of the current archive was 'repatriated' from international cooperators and often required the reconstruction of (sometimes absent) metadata for geo-location and radiometric calibration. The older MSS data, some of which had been successfully retrieved from outdated wide band video media, required similar metadata reconstruction. TM data from Landsats 4 and 5 relied on questionable on-board lamp data for calibration, thus the calibration history for these missions was reconstructed to account for sensor degradation over time. To improve continuity between platforms, Landsat 7 and 8 missions employed 'under-flight' maneuvers to reduce inter-calibration error. Data from the various sensors, platforms and sources were integrated into a common metadata standard, with quality assurance information, to ensure understandability of the data for long-term preservation. Because of these efforts, the current Landsat archive can now support the creation of the long-term climate data records and essential climate variables required to monitor changes on the Earth's surface quantitatively over decades of observations.

  12. Forty years of acting electron-positron colliders

    E-print Network

    V. N. Baier

    2006-11-15

    Around forty years passed from the beginning of operation of the first electron-positron colliding beam facility VEPP-2 in Institute of Nuclear Physics (INP), Novosibirsk. Here I described development of electron-positron colliding beam project in INP, as well as advance of similar projects of the first generation at LAL, Orsay and at LNF, Frascati.

  13. Sciatic Neuroma Presenting Forty Years After Above-Knee Amputation

    PubMed Central

    Kitcat, M; Hunter, J.E; Malata, C.M

    2009-01-01

    We report a case of a sciatic neuroma presenting forty years after above knee amputation. Patients developing neuroma following a limb amputation can present with stump pain which is commonly resistant to medical intervention. The length of interval from the initial injury to presentation is widely variable. Diagnosis relies on clinical suspicion and accurate assessment, radiological imaging and, if indicated, surgical exploration. MRI provides a better soft tissue definition than CT and is more accurate in identifying small lesions than ultrasound. The aim of treatment for symptomatic neuroma is pain relief and improvement of function. This is often achieved by surgical excision. PMID:20224738

  14. Looking Backward, Looking Forward: Forty Years of US Human Spaceflight Symposium

    NASA Technical Reports Server (NTRS)

    Garber, Stephen J. (Editor); Launius, Roger (Technical Monitor)

    2001-01-01

    This symposium reflects on forty years of U.S. Human Spaceflight, its role over the next four decades and beyond. The topics include: 1) Perspectives on the Past Forty Years of Human Spaceflight; 2) The Experience of Spaceflight; 3) Perspectives on the Next Forty Years of Human Spaceflight; and 4) The International Space Station and the Future of Human Spaceflight.

  15. Bilingualism in Paraguay: Forty Years after Rubin's Study

    ERIC Educational Resources Information Center

    Choi, Jinny K.

    2005-01-01

    Nearly 40 years have passed since the publication of Rubin's renowned study on Paraguayan bilingualism. The present study compares the results of surveys conducted in the years 2000-2001 with data from Rubin's 1960-1961 investigation. The main objective of this study is to examine the linguistic changes that have occurred in four decades and the…

  16. Reconsidering Sputnik: Forty Years Since the Soviet Satellite

    NASA Technical Reports Server (NTRS)

    Launius, Roger D. (Editor)

    1997-01-01

    This collection of essays explore several broad themes: the Soviet Union and Sputnik, space and the international Geophysical Year, the immediate ramifications of Sputnik in the United States, and the significance of Sputnik throughout the world.

  17. Forty years on from Aerobee 150: a personal perspective.

    PubMed

    Pounds, Ken

    2002-09-15

    X-ray astronomy has evolved from a chance beginning 40 years ago to become a major branch of observational astronomy, underpinning a revolution in high-energy astrophysics. The intervening development can be seen in three phases, starting in the 1960s with a decade of pioneering exploration with sounding rockets, and consolidated by further discoveries with a series of dedicated small satellites, led by Uhuru, building up to NASA's HEAO-1 and Einstein Observatory missions in 1978-1981. The remaining years of the last century saw X-ray astronomy become a broad international effort with strong contributions from Europe and Japan balancing a temporary loss of momentum in the NASA programme. A brief account of those early years in X-ray astronomy is given, from a personal (UK) perspective, as an introduction to the review of the current status of the discipline, which was the subject of the Discussion Meeting. PMID:12804236

  18. Forty Years of Library Automation: A Personal Reflection

    ERIC Educational Resources Information Center

    Line, Maurice B.

    2006-01-01

    Purpose: To provide an overview of one person's involvement with computer systems in libraries over the last 40 years. Design/methodology/approach: Personal memories corroborated with published articles. Findings: There have been very many developments in libraries in a comparatively short period of time as a result of using computer systems, and…

  19. Forty six years of health financing in Fiji (1962 - 2008).

    PubMed

    Lingam, Dharam; Roberts, Graham

    2009-11-01

    This paper provides an analysis of the Fiji Ministry of Health (MoH) budget for the last 46 years, its share of the national budget and annual percentage of GDP, its revenues, per-capita health expenditure, staff costs, and the performance on key population health indicators and Millennium Development Goals (MDGs). Despite annual increases in dollar terms, the proportion of GDP allocated to the national public health system has fallen from 4% to 2.6% over the last 15 years. Consequently the national performance on key health service indicators and MDGs is declining and health staff are migrating. We outline factors to retrieve the public health system in Fiji, such as the need for political commitment to the health of the people, public policy debate on the nature of the health system, the revision of hospital charges, the need to protect the poor by strengthening means testing, and propose compulsory health insurance for the employed. PMID:20443521

  20. Forty-five year follow-up after uninephrectomy.

    PubMed

    Narkun-Burgess, D M; Nolan, C R; Norman, J E; Page, W F; Miller, P L; Meyer, T W

    1993-05-01

    This study examined the consequences of nephrectomy in United States Army personnel who lost a kidney due to trauma during World War II (WWII). Records of 62 servicemen who underwent nephrectomy at an average age of 25 years were obtained. Mortality was compared with that of WWII servicemen of the same age. Medical records of 28 deceased subjects were reviewed for evidence of kidney disease. Medical histories were obtained and blood pressure and kidney function were assessed in 28 living subjects. Two subjects could not be located, and four subjects declined to participate. Mortality at 45 years was not increased in nephrectomized subjects. Kidney disease present in six of 28 deceased subjects was attributable to causes other than prior nephrectomy. Glomerular sclerosis was not increased in 10 subjects who had autopsy examinations. The prevalence of hypertension was not increased in living subjects. Five of 28 living subjects had abnormal renal function manifested by proteinuria greater than 250 mg/day in four cases (range: 377 to 535 mg/day) and serum creatinine levels greater than 1.5 mg/dl in three cases (range: 1.7 to 1.9 mg/dl). Conditions other than nephrectomy could have contributed to impairment of renal function in each of these subjects. These findings suggest that uninephrectomy in young adults has few major adverse consequences over 45 years. PMID:8510390

  1. A Forty Year Odyssey in Metallo-Organic Chemistry.

    PubMed

    Nicholas, Kenneth M

    2015-07-17

    In this invited Perspective, I provide a personal account highlighting several of my group's research contributions in metallo-organic chemistry over the past 40 years. Our early work focused primarily in stoichiometric structure/reactivity of transition metal-organic compounds and their use in organic synthesis. More recent efforts have centered on the discovery and development of new metal-catalyzed organic reactions via reactive metal-organic intermediates. The major research findings that are described here include (1) propargyl-cobalt complexes as electrophilic agents for C-C and C-Nu coupling; (2) the activation of carbon dioxide by metal complexes; (3) metal-promoted C-H nitrogenation reactions; (4) oxo-metal catalyzed deoxygenation reactions; and (5) catalyst discovery via dynamic templating with substrate- and transition-state analogues. PMID:26035082

  2. Forty years of vegetation change on the Missouri River Floodplain

    USGS Publications Warehouse

    Johnson, W.C.; Dixon, M.D.; Scott, M.L.; Rabbe, L.; Larson, G.; Volke, M.; Werner, B.

    2012-01-01

    Comparative inventories in 1969 and 1970 and in 2008 of vegetation from 30 forest stands downstream of Garrison Dam on the Missouri River in central North Dakota showed (a) a sharp decline in Cottonwood regeneration; (b) a strong compositional shift toward dominance by green ash; and (c) large increases in invasive understory species, such as smooth brome, reed canary grass, and Canada thistle. These changes, and others discovered during remeasurement, have been caused by a complex of factors, some related to damming (altered hydrologic and sediment regimes, delta formation, and associated wetdry cycles) and some not (diseases and expansion of invasive plants). Dominance of green ash, however, may be short lived, given the likelihood that the emerald ash borer will arrive in the Dakotas in 510 years, with potentially devastating effects. The prospects for recovery of this valuable ecosystem, rich in ecosystem goods and services and in American history, are daunting. ?? 2012 by American Institute of Biological Sciences. All rights reserved.

  3. Forty years on: how radiological protection has evolved internationally.

    PubMed

    Sowby, David; Valentin, Jack

    2003-06-01

    In the 40 years since the Society for Radiological Protection (SRP) was founded, the international scene has changed considerably. The United Nations bodies primarily involved, the United Nations Scientific Committee on the Effects of Atomic Radiation and the International Atomic Energy Agency, have evolved from fledgling organisations to indispensable major resources. A similar development characterises regional entities such as Euratom and the OECD Nuclear Energy Agency. The International Commission on Radiological Protection (ICRP), once interested in occupational health in the practice of medicine only, has shifted its emphasis towards protection of members of the public and of patients exposed to ionising radiations and is currently looking at protection of non-human species. The International Radiation Protection Association, the federation that is now the 'mother society' of the SRP, had not even been launched formally when the SRP started. At that time, non-ionising radiation was on nobody's mind, and the forerunner of today's International Commission on Non-Ionizing Radiation Protection (ICNIRP) was not formed until 1977. Basically, the developments during this period must be described as a great success story. Average occupational exposures to ionising radiation have decreased markedly, the number of accidents is small, almost all countries now regulate exposures roughly in line with ICRP and ICNIRP recommendations, and quite a large number of countries also have reasonable regulatory infrastructures. An area where problems appear to be on the increase, perhaps in part because of increasing awareness, concerns 'orphan sources' and lack of source security. This may indicate a need for closer attention to security outside the nuclear fuel cycle, e.g. in hospitals and non-nuclear industry. PMID:12875548

  4. Forty-four years of studying light adaptation using the probed-sinewave paradigm

    E-print Network

    Columbia University

    Forty-four years of studying light adaptation using the probed-sinewave paradigm Columbia-sinewave, light adaptation, computational models, temporal dynamics, flicker Introduction Over the past 44 years of Psychology, New York, NY, USANorma Graham Here we examine results from 44 years of probed

  5. Forty-five years of observed soil moisture in the Ukraine: No summer desiccation (yet)

    E-print Network

    Robock, Alan

    Forty-five years of observed soil moisture in the Ukraine: No summer desiccation (yet) Alan Robock­October for 141 stations from fields with either winter or spring cereals from the Ukraine for 1958­2002. We-five years of observed soil moisture in the Ukraine: No summer desiccation (yet), Geophys. Res. Lett., 32, L

  6. Total Elbow Arthroplasty in Patients Forty Years of Age or Less

    Microsoft Academic Search

    Bernard F. Morrey

    2009-01-01

    Background: It is generally accepted that prosthetic elbow replacement should be avoided in young patients because of an anticipated high rate of early failure. The purpose of this paper was to define the success, prosthetic survival rate, and problems encountered in patients who were treated with a semiconstrained total elbow arthroplasty when they were forty years of age or less.

  7. THE 2010 HORIZONTAL MERGER GUIDELINES: FROM HEDGEHOG TO FOX IN FORTY YEARS

    E-print Network

    Sadoulet, Elisabeth

    THE 2010 HORIZONTAL MERGER GUIDELINES: FROM HEDGEHOG TO FOX IN FORTY YEARS CARL SHAPIRO* The U PERSPECTIVE: THE HEDGEHOG AND THE FOX The 2010 Guidelines are best understood in historical context the Hedgehog and the Fox view the world is a useful model for how to think about the evolution of the Merger

  8. Still "Unfinished Education": Latino Students Forty Years after the Mexican American Education Study

    ERIC Educational Resources Information Center

    Madrigal-Gonzalez, Lizely

    2012-01-01

    The onus of this dissertation was to evaluate the educational conditions of Mexican American students forty years after the "Mexican American Education Study" published a six-volume study detailing the findings of the "Mexican American Education Study" (1970-1974). The "MAES" study focused on five southwest states…

  9. NOAA Technical Memorandum NMFS-PIFSC-40 Forty Years of Research: Recovery Records

    E-print Network

    NOAA Technical Memorandum NMFS-PIFSC-40 May 2014 Forty Years of Research: Recovery Records of Green Science Center (PIFSC) uses the NOAA Technical Memorandum NMFS series to achieve timely dissemination of scientific and technical information that is of high quality but inappropriate for publication in the formal

  10. Supplemental Material for Forty Five Years of Observed Soil Moisture in the Ukraine: No

    E-print Network

    Robock, Alan

    Supplemental Material for Forty Five Years of Observed Soil Moisture in the Ukraine: No Summer, Kiev, Ukraine 5 Agrometeorology Department, Ukrainian Hydrometeorological Centre, Kiev, Ukraine The individual soil moisture stations in the Ukraine are shown in Figure 1. The data are averaged into the 25

  11. B uchi Complementation: A FortyYear Saga Moshe Y. Vardi #

    E-print Network

    Vardi, Moshe Y.

    BË? uchi Complementation: A Forty­Year Saga Moshe Y. Vardi # Rice University March 23, 2006 The complementation problem for nondeterministic word automata has numerous applications in formal verification A 2 , one checks that the intersection of A 1 with an automaton that complements A 2 is empty. Many

  12. Forty years on --the Hall Effect with constant-voltage Peter Fenwick

    E-print Network

    Fenwick, Peter

    -fashioned) for studying the Zeeman effect. The other produced a lower field, about 0.3 T, but very uniformForty years on -- the Hall Effect with constant-voltage drive Peter Fenwick July 12, 2006 Abstract. The problem itself involves the solution of potentials over a Hall-effect plate driven with a constant voltage

  13. Learning from the Tragedy at Kent State: Forty Years after May 4

    ERIC Educational Resources Information Center

    Eckert, Erica

    2010-01-01

    In this article, the author reflects on the learning opportunities provided by the tragedy at Kent State University forty years ago for educators and learners. Four students were slain and nine students were wounded by the bullets of National Guardsmen who had been sent to quell anti-war demonstrations and vandalism. The events of May 4, 1970,…

  14. Forty Years of Land Use and Land Ownership Change in Central Sierra Nevada

    E-print Network

    Standiford, Richard B.

    Forty Years of Land Use and Land Ownership Change in Central Sierra Nevada Oak Woodlands1 Matt owned, and, therefore, highly susceptible to changes in land use and ownership as well as land fragmentation. This is particularly true in the Central Sierra Nevada, where significant changes in land use

  15. The Poisoning in Hong Kong --An Episode of Life in China Forty Years Ago

    E-print Network

    Gray, Robert M.

    The Poisoning in Hong Kong -- An Episode of Life in China Forty Years Ago by Augustine Heard poisoning incident in 1857 during the second Anglo-Chinese war. The following is transcribed from is poisoned. Take mustard [teaspoonful] in warm water; 1/2 pint & afterwards warm water; after vomiting freely

  16. Looking Backward, Looking Forward: Forty Years of US Human Spaceflight Symposium

    NSDL National Science Digital Library

    Garber, Stephen J.

    2002-01-01

    NASA's History Office Web site is offering a publication for public review entitled Looking Backward, Looking Forward: Forty Years of US Human Spaceflight Symposium. The two hundred and fifty page document chronicles NASA's history from the Sputnik era to the present including insights from Buzz Aldrin, perspectives on the future, the international space station, and much more. Readers will enjoy the frank discussions, telling photographs, and keen insights from those involved with this sometimes dangerous and always breathtaking pursuit.

  17. Forty-five years of split-brain research and still going strong

    Microsoft Academic Search

    Michael S. Gazzaniga

    2005-01-01

    Forty-five years ago, Roger Sperry, Joseph Bogen and I embarked on what are now known as the modern split-brain studies. These experiments opened up new frontiers in brain research and gave rise to much of what we know about hemispheric specialization and integration. The latest developments in split-brain research build on the groundwork laid by those early studies. Split-brain methodology,

  18. Global Forty-Years Validation of Seasonal Precipitation Forecasts: Assessing El Ni\\~no-Driven Skill

    E-print Network

    Manzanas, R; Cofiño, A S; Gutiérrez, J M

    2013-01-01

    The skill of seasonal precipitation forecasts is assessed worldwide -grid point by grid point- for the forty-years period 1961-2000. To this aim, the ENSEMBLES multi-model hindcast is considered. Although predictability varies with region, season and lead-time, results indicate that 1) significant skill is mainly located in the tropics -20 to 40% of the total land areas-, 2) overall, SON (MAM) is the most (less) skillful season and 3) predictability does not decrease noticeably from one to four months lead-time -this is so especially in northern south America and the Malay archipelago, which seem to be the most skillful regions of the world-. An analysis of teleconnections revealed that most of the skillful zones exhibit significant teleconnections with El Ni\\~no. Furthermore, models are shown to reproduce similar teleconnection patterns to those observed, especially in SON -with spatial correlations of around 0.6 in the tropics-. Moreover, these correlations are systematically higher for the skillful areas. ...

  19. Neurostimulation for traumatic brain injury.

    PubMed

    Shin, Samuel S; Dixon, C Edward; Okonkwo, David O; Richardson, R Mark

    2014-11-01

    Traumatic brain injury (TBI) remains a significant public health problem and is a leading cause of death and disability in many countries. Durable treatments for neurological function deficits following TBI have been elusive, as there are currently no FDA-approved therapeutic modalities for mitigating the consequences of TBI. Neurostimulation strategies using various forms of electrical stimulation have recently been applied to treat functional deficits in animal models and clinical stroke trials. The results from these studies suggest that neurostimulation may augment improvements in both motor and cognitive deficits after brain injury. Several studies have taken this approach in animal models of TBI, showing both behavioral enhancement and biological evidence of recovery. There have been only a few studies using deep brain stimulation (DBS) in human TBI patients, and future studies are warranted to validate the feasibility of this technique in the clinical treatment of TBI. In this review, the authors summarize insights from studies employing neurostimulation techniques in the setting of brain injury. Moreover, they relate these findings to the future prospect of using DBS to ameliorate motor and cognitive deficits following TBI. PMID:25170668

  20. A Reviewof Forty-Five YearsStudy of Hiroshimaand Nagasaki Atomic BombSurvivors II. BIOLOGICAL EFFECTS

    E-print Network

    Laughlin, Robert B.

    A Reviewof Forty-Five YearsStudy of Hiroshimaand Nagasaki Atomic BombSurvivors II. BIOLOGICAL EFFECTS Atomic Bomb and Leukemia MICHITO ICHIMARU, MASAO TOMONAGA, TATSUHIKO AMENOMORI AND TATSUKI MATSUO,and the occurrenceof CML wasthought to be most characteristic for atomic bomb radiation induced leukemia

  1. The injectable neurostimulator: an emerging therapeutic device.

    PubMed

    Li, Xiaolong; Serdijn, Wouter A; Zheng, Wei; Tian, Yubo; Zhang, Bing

    2015-07-01

    Injectable neurostimulators are currently applied in clinical trials to minimize the side effects such as discomfort, risk of infection, and post-surgery trauma, which can be pronounced with conventional, bulky implantable neurostimulators. Owing to its smaller size, wireless-updatable software, and wireless power supply, the injectable neurostimulator is presumably less invasive, 'smarter', and has a longer lifetime. We discuss the concept and development of the injectable neurostimulator, persistent implementation challenges, and obstacles to be overcome in its evolution. We survey the use of new materials, technologies, and design methods for injectable electrodes, batteries, antennas, and packaging to enhance reliability and other features. These advances in the field are accompanied by progress in electrophysiology, neuroscience, neurology, clinical trials, and treatments. PMID:25921343

  2. Role of neurostimulation in migraine.

    PubMed

    Grazzi, L; Padovan, A; Barbanti, P

    2015-05-01

    Chronic forms of headache characterized by daily or almost daily headache, affect almost 3 % of general population. They represent the most disabling forms of headache inducing high degree of disability, poor quality of life for patients. During the last decades, several neuromodulatory surgical techniques have been developed for the management of headaches that are unresponsive to medical treatment. Invasive and non invasive central and/or peripheral neurostimulation techniques have been developed by different research groups with encouraging results for different type of headaches. In this report, the acute effect of non invasive vagus nerve stimulation (nVNS) (gammacore) was evaluated to treat migraine attacks in a population of patients affected by high-frequency episodic migraine or chronic migraine. The aim of this study was to verify the efficacy of nVNS to treat migraine attacks in this specific category of patients. PMID:26017526

  3. A study of the factors influencing forty years' operations on a large Texas cattle ranch 

    E-print Network

    Matthews, Joseph Luther

    1947-01-01

    ties in 19'5v clan the-. e were "" head. . ho xxxsxber of stesx' ard hoi. er calves on hand hue Varied frcn your tc year aCCOrlini, - LO tbc '. O'. iVery dates Of' thc OalVee sold . "ow steer calves h*, vw bess cari"xa! ovor into the ollowinn year...

  4. Neurostimulation for Drug-Resistant Epilepsy

    PubMed Central

    DeGiorgio, Christopher M.; Krahl, Scott E.

    2013-01-01

    Purpose of Review: The purpose of this review is to provide an evidence-based update on the neurostimulation options available for patients with drug-resistant epilepsy in the United States and in European countries. Recent Findings: The field of neurostimulation for epilepsy has grown dramatically since 1997, when vagus nerve stimulation became the first device to be approved for epilepsy by the US Food and Drug Administration (FDA). New data from recently completed randomized controlled trials are available for deep brain stimulation of the anterior thalamus, responsive neurostimulation, and trigeminal nerve stimulation. Although vagus nerve stimulation is the only device currently approved in the United States, deep brain stimulation and responsive neurostimulation devices are awaiting FDA approval. Deep brain stimulation, trigeminal nerve stimulation, and transcutaneous vagus nerve stimulation are now approved for epilepsy in the European Union. In this article, the mechanisms of action, safety, and efficacy of new neurostimulation devices are reviewed, and the key advantages and disadvantages of each are discussed. Summary: The exponential growth of the field of neuromodulation for epilepsy is an exciting development; these new devices provide physicians with new options for patients with drug-resistant epilepsy. PMID:23739108

  5. Forty Years of Finnish Pre-School Education: The Development of Curricula between 1972 and 2000

    ERIC Educational Resources Information Center

    Turunen, Tuija A.; Maatta, Kaarina; Uusiautti, Satu

    2012-01-01

    Since 2001 in Finland, all six year olds have had the right to free pre-school education, and almost all pre-school-aged children take advantage of this opportunity. The purpose of this article is to dissect the development of Finnish pre-school education curricula within the societal context and within the changes in trends of curriculum planning…

  6. Forty Years on: Presidential Address to the History of Education Society, London, 4 November 2006

    ERIC Educational Resources Information Center

    McCulloch, Gary

    2007-01-01

    This paper, based on the author's presidential address to the History of Education Society in November 2006, explores aspects of continuity and change over the past 40 years with particular reference to educational reform and the development of the History of Education Society itself. It assesses the significance of the work of the playwright Alan…

  7. Forty Years Of Artificial Selection In U.S. Holstein Cattle Had Genome-wide Signatures

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genome signatures of 40 years of artificial selection in U.S. Holstein cattle were identified by comparing allele frequencies and extended haplotype homozygosity in a Holstein resource population composed of a contemporary group, a group born in 1975-1985, and a group unselected since 1964. Results ...

  8. Forty years of microbial photosynthesis research: Where it came from and what it led to

    Microsoft Academic Search

    R. Clinton Fuller

    1999-01-01

    What follows is a very personal account of my professional life and the early years that preceded it. I have described the social and economic conditions in America and how the nineteen twenties and thirties nurtured our scientific future. The description of the early part of post-World War II research covers my experience in the areas of nutritional biochemistry, biochemical

  9. Forty Years of Progress in Community Mental Health: The Role of Evidence-Based Practices

    Microsoft Academic Search

    Lisa Dixon; Howard Goldman

    2004-01-01

    The community mental health movement in the U.S. peaked in 1963 with the passage of the Community Mental Health Centers (CMHC) Act. The movement had its origins in the two decades before 1963, beginning with World War II, and matured in the 20 years that followed. The CMHC legislation stood at the mid point of a cycle of reform, in

  10. Forty years of ZERODUR mirror substrates for astronomy: review and outlook

    Microsoft Academic Search

    Thorsten Döhring; Ralf Jedamzik; Armin Thomas; Peter Hartmann

    2008-01-01

    Initiated in 1968 by the first order of the Max-Planck-Institute in Heidelberg the successful history of ZERODUR® continues now since 40 years. ZERODUR® zero expansion glass ceramic from SCHOTT has been the material of choice in astronomy for decades, thanks to its special properties such as its extremely high thermal and mechanical stability. Today most of the major modern optical

  11. Forty years of 90Sr in situ migration: importance of soil characterization in modeling transport phenomena.

    PubMed

    Fernandez, J M; Piault, E; Macouillard, D; Juncos, C

    2006-01-01

    In 1960 experiments were carried out on the transfer of (90)Sr between soil, grapes and wine. The experiments were conducted in situ on a piece of land limited by two control strips. The (90)Sr migration over the last 40 years was studied by performing radiological and physico-chemical characterizations of the soil on eight 70 cm deep cores. The vertical migration modeling of (90)Sr required the definition of a triple layer conceptual model integrating the rainwater infiltration at constant flux as the only external factor of influence. Afterwards the importance of a detailed soil characterization for modeling was discussed and satisfactory simulation of the (90)Sr vertical transport was obtained and showed a calculated migration rate of about 1.0 cm year(-1) in full agreement with the in situ measured values. The discussion was regarding some of the key parameters such as granulometry, organic matter content (in the Van Genuchten parameter determination), Kd and the efficient rainwater infiltration. Besides the experimental data, simplifying assumptions in modeling such as water-soil redistribution calculation and factual discontinuities in conceptual model were examined. PMID:16430998

  12. The ODAS Italia 1 buoy: More than forty years of activity in the Ligurian Sea

    NASA Astrophysics Data System (ADS)

    Canepa, Elisa; Pensieri, Sara; Bozzano, Roberto; Faimali, Marco; Traverso, Pierluigi; Cavaleri, Luigi

    2015-06-01

    The Ligurian Sea plays a relevant role in driving both the circulation of the Western Mediterranean Sea and the weather and climate of the area. In order to better understand the peculiarities of this basin, the Oceanographic Data Acquisition System (ODAS) Italia 1 buoy was developed and deployed in the early '70s. Throughout the years, the buoy has been fitted with updated measuring and data acquiring systems. Since 2003 the buoy has been part of the Mediterranean Moored Multi-sensor Array network of fixed open ocean observatories with the W1-M3A identifier and presently constitutes one of the Mediterranean sites of the European FixO3 network. Recently, a deep-ocean sub-surface mooring line was, and is, deployed close to it in relation to specific projects. This multidisciplinary observing system is able to perform both long-term operational and ad-hoc monitoring from the lower atmosphere to the deep ocean. It is used for analysis of air-sea interaction processes, study of the physical proprieties of the water column, bio-geo-chemical monitoring of the sea, meteorological and oceanographic model evaluation, calibration of remotely sensed measurements, and development of innovative marine monitoring technologies. After reporting some historical notes and the description of the observing system, this paper summarises and reviews the main oceanographic and atmospheric studies performed during the last 15 years using the data acquired on board.

  13. Forty years of ZERODUR mirror substrates for astronomy: review and outlook

    NASA Astrophysics Data System (ADS)

    Döhring, Thorsten; Jedamzik, Ralf; Thomas, Armin; Hartmann, Peter

    2008-07-01

    Initiated in 1968 by the first order of the Max-Planck-Institute in Heidelberg the successful history of ZERODUR® continues now since 40 years. ZERODUR® zero expansion glass ceramic from SCHOTT has been the material of choice in astronomy for decades, thanks to its special properties such as its extremely high thermal and mechanical stability. Today most of the major modern optical telescopes of the 4 m class and of the 8 m to 10 m class are equipped with ZERODUR®. For the future several Extremely Large Telescope (ELT) projects are in development, which are designed with even larger primary mirrors ranging from 30 m to 42 m. Also here ZERODUR® is under consideration. A historical review, the actual status of developments and an outlook to the future is given in this paper.

  14. Forty million years of mutualism: Evidence for Eocene origin of the yucca-yucca moth association

    PubMed Central

    Pellmyr, Olle; Leebens-Mack, James

    1999-01-01

    The obligate mutualism between yuccas and yucca moths is a major model system for the study of coevolving species interactions. Exploration of the processes that have generated current diversity and associations within this mutualism requires robust phylogenies and timelines for both moths and yuccas. Here we establish a molecular clock for the moths based on mtDNA and use it to estimate the time of major life history events within the yucca moths. Colonization of yuccas had occurred by 41.5 ± 9.8 million years ago (Mya), with rapid life history diversification and the emergence of pollinators within 0–6 My after yucca colonization. A subsequent burst of diversification 3.2 ± 1.8 Mya coincided with evolution of arid habitats in western North America. Derived nonpollinating cheater yucca moths evolved 1.26 ± 0.96 Mya. The estimated age of the moths far predates the host fossil record, but is consistent with suggested host age based on paleobotanical, climatological, biogeographical, and geological data, and a tentative estimation from an rbcL-based molecular clock for yuccas. The moth data are used to establish three alternative scenarios of how the moths and plants have coevolved. They yield specific predictions that can be tested once a robust plant phylogeny becomes available. PMID:10430916

  15. [The development of Rein van Bemmelens (1904-1983) undation theory: forty years of Dutch geology].

    PubMed

    Barzilay, Willemjan

    2009-01-01

    The Dutch geologist Rein van Bemmelen was the greatest opponent of plate tectonics in The Netherlands. He lived and worked during an important period in the history of earth sciences. He had studied geology when Wegeners theory was introduced and enthusiastically received in the Netherlands and he worked as a geologists during the period in which, after Wegeners theory was rejected in The Netherlands, several Dutch geologists came with their own theories to explain the origin of continents and oceans and in which plate tectonics was introduced in The Netherlands. He had proposed his own theory, the undation theory, at the beginning of the 1930s and kept on developing it during the following years. He continued to do so until his death in 1983. The history of the undation theory thus sheds light on the history of geology in The Netherlands. I will trace the history of geology in The Netherlands using Rein van Bemmelen and his undation theory as a lens. PMID:22586775

  16. State of the art in PEGylation: the great versatility achieved after forty years of research.

    PubMed

    Pasut, Gianfranco; Veronese, Francesco M

    2012-07-20

    In the recent years, protein PEGylation has become an established and highly refined technology by moving forward from initial simple random coupling approaches based on conjugation at the level of lysine ?-amino group. Nevertheless, amino PEGylation is still yielding important conjugates, currently in clinical practice, where the degree of homogeneity was improved by optimizing the reaction conditions and implementing the purification processes. However, the current research is mainly focused on methods of site-selective PEGylation that allow the obtainment of a single isomer, thus highly increasing the degree of homogeneity and the preservation of bioactivity. Protein N-terminus and free cysteines were the first sites exploited for selective PEGylation but currently further positions can be addressed thanks to approaches like bridging PEGylation (disulphide bridges), enzymatic PEGylation (glutamines and C-terminus) and glycoPEGylation (sites of O- and N-glycosylation or the glycans of a glycoprotein). Furthermore, by combining the tools of genetic engineering with specific PEGylation approaches, the polymer can be basically coupled at any position on the protein surface, owing to the substitution of a properly chosen amino acid in the sequence with a natural or unnatural amino acid bearing an orthogonal reactive group. On the other hand, PEGylation has not achieved the same success in the delivery of small drugs, despite the large interest and several studies in this field. Targeted conjugates and PEGs for combination therapy might represent the promising answers for the so far unmet needs of PEG as carrier of small drugs. This review presents a thorough panorama of recent advances in the field of PEGylation. PMID:22094104

  17. Dreams, Hopes, Realities: NASA's Goddard Space Flight Center, the First Forty Years

    NASA Technical Reports Server (NTRS)

    Wallace, Lane E.

    1999-01-01

    Throughout history, the great achievements of civilizations and cultures have been recorded in lists of dates and events. But to look only at the machinery, discoveries, or milestones is to miss the value of these achievements. Each goal achieved or discovery or made represents a supreme effort on the part of individual people who came and worked together for a purpose greater than themselves. Driven by an innate curiosity of the spirit, we have built civilizations and discovered new worlds, always reaching out beyond what we knew or thought was possible. These efforts may have used ships or machinery, but the achievement was that of the humans who made those machines possible- remarkable people willing to endure discomfort, frustration, fatigue, and the risk of failure in the hope of finding out something new. This is the case with the history of the Goddard Space Flight Center. This publication traces the legacy of successes, risks, disappointments and internationally recognized triumphs of the Center's first 40 years. It is a story of technological achievement and scientific discovery; of reaching back to the dawn of time and opening up a new set of eyes on our own planet Earth. In the end, it is not a story about machinery or discoveries, but a story about ourselves. If we were able to step off our planet, and if we continue to discover new mysteries and better technology, it is because the people who work at Goddard always had a passion for exploration and the dedication to make it happen. The text that follows is a testimony to the challenges people at the Goddard Space Flight Center have faced and overcome over almost half a century. Today, we stand on the threshold of a new and equally challenging era. It will once again test our ingenuity, skills, and flexibility as we find new ways of working with our colleagues in industry, government, and academia. Doing more with less is every bit as ambitious as designing the first science instrument to study the heavens. But if we are to continue exploring our world and our universe, it is every bit as important. Robert H. Goddard once said, "The dream of yesterday is the hope of today and the reality of tomorrow." This is our heritage. Our challenge is to keep our spirit of dedication, vision, and innovative thinking alive, so we can turn today's dreams into a new century of possibility and progress. Our journeys into space are the greatest ongoing adventure the human race has ever undertaken, and everyone here has played an important role in that endeavor. This book is about everyone who has worked at the Goddard Space Flight Center.

  18. Selected topics from forty years of natural products research: betalains to flavonoids, antiviral proteins, and neurotoxic nonprotein amino acids.

    PubMed

    Mabry, T J

    2001-12-01

    The elucidation by NMR and chemical methods of the unique structure of betanidin, the aglycon of the red-violet beet pigment betanin, forty years ago at the University of Zürich, Switzerland, was the beginning of my plant chemistry research program. Many of the same chemical and spectral techniques developed in Zürich have been used at The University of Texas at Austin for the structure analysis of members of many other classes of natural products including especially flavonoids, terpenoids, and alkaloids. Investigations at UT-Austin have concerned many topics such as biochemical and molecular systematics, biosynthetic pathways, structure-activity relationships, and the medicinal importance of natural products and included studies of antiviral proteins in the genus Phytolacca and neurotoxic nonprotein amino acids from cycads and other sources. Following the betalain story and an account of the early development of my UT-Austin biochemical systematic program, the Phytolacca and neurotoxin investigations are discussed herein. PMID:11754626

  19. The peripatetic cultural psychiatrist: reflections on a forty-five year longitudinal study of a South India village.

    PubMed

    Ullrich, Helen E

    2011-04-01

    This article presents one woman's odyssey, which began with a career in linguistics and later incorporated cultural psychiatry. While engaged in fieldwork as a linguist, studying the syntactic structure of Havyaka Kannada and dialectal accommodation among the castes in a South India village, I developed language skills and rapport with the village residents. Then I transferred my community-wide rapport to research on depression as a cultural psychiatrist. The articles I wrote on depression and its relationship to socialized passivity and endorsed assertiveness in progressive generations of South Indian women, illustrate the impact of change on mental health. The cultural background from my community-based longitudinal study of more than forty-five years has contributed to my understanding disorders in Indian patients living in a globalized world. PMID:21511853

  20. SEMPRE: Forty Years on

    ERIC Educational Resources Information Center

    Cox, Gordon; Crickmore, Leon; Plummeridge, Charles; Sergeant, Desmond

    2012-01-01

    This historical account traces the beginnings of the Society for Education, Music and Psychology Research (SEMPRE) to the founding of the Society for Research in Psychology of Music and Music Education (SRPMME) in 1972, which in turn had evolved from Arnold Bentley's Research in Music Education conferences instituted in 1966. The paper charts the…

  1. A Band of Sisters: The Impact of Long-Term Small Group Participation--Forty Years in a Women's Prayer and Bible Study Group

    ERIC Educational Resources Information Center

    Lawson, Kevin E.

    2006-01-01

    This article reports on a case study of a women's prayer and Bible study group that has met for over forty years. The report focuses on factors contributing to the group's longevity and vitality over time, how it changed over the years, and its impact on the lives of the women who participated in it. It also addresses how this long-term group…

  2. Building on and Honoring Forty Years of PBL Scholarship from Howard Barrows: A Scientometric, Large-Scale Data, and Visualization-Based Analysis

    ERIC Educational Resources Information Center

    Xian, Hanjun; Madhavan, Krishna

    2013-01-01

    Over the past forty years, Howard Barrows' contributions to PBL research have influenced and guided educational research and practice in a diversity of domains. It is necessary to make visible to all PBL scholars what has been accomplished, what is perceived as significant, and what is the scope of applicability for Barrows' groundbreaking…

  3. Neurostimulation: a new way to influence cortical excitability?

    PubMed

    Bestmann, Sven

    2011-11-01

    Recent work in humans suggests that strong static magnets can modulate cortical excitability for a limited period of time. Can this provide an alternative to current neurostimulation approaches? PMID:22075430

  4. La neurostimulation transcutanée dans le traitement des douleurs chroniques

    Microsoft Academic Search

    B. Brochet

    1996-01-01

    Résumé  La neurostimulation transcutanée est largement utilisée dans le traitement des douleurs chroniques depuis la publication parMeizack etWall de la théorie du Gate Control. Son utilisation doit répondre à des règles précises afin d’en tirer le meilleur résultat.\\u000a La neurostimulation conventionnelle utilise des fréquences de 100 Hz environ. Elle doit être appliquée sur le trajet d’un\\u000a nerf périphérique. Les meilleures indications

  5. Fibre optics: Forty years later

    SciTech Connect

    Dianov, Evgenii M [Fiber Optics Research Center, Russian Academy of Sciences, Moscow (Russian Federation)

    2010-01-31

    This paper presents a brief overview of the state of the art in fibre optics and its main applications: optical fibre communications, fibre lasers and fibre sensors for various physical property measurements. The future of fibre optics and the status of this important area of the modern technology in Russia are discussed. (fiber optics)

  6. Forty years of nonlinear ultrasound.

    PubMed

    Bjørnø, Leif

    2002-05-01

    Nonlinear ultrasound forms an integrated discipline of nonlinear acoustics founded in 1755. A short outline of the state-of-the-art in nonlinear ultrasound in 1960 forms the introduction to this paper. Some of the most important contributions to the development in the theoretical, analytical and numerical basis of nonlinear ultrasound and in experimental investigations of nonlinear ultrasonic processes published during the period of 1960 through 2000 are discussed and their successes and failures in practical exploitation are illuminated. A more detailed treatment is given of research achievements in nonlinearity of fluids, in focused ultrasonic field, in parametric acoustic arrays and in thermoacoustics. An attempt is made to point out some fields of research in nonlinear ultrasound where future efforts should be concentrated. PMID:12159916

  7. Analysis of induced electrical currents from magnetic field coupling inside implantable neurostimulator leads

    PubMed Central

    2011-01-01

    Background Over the last decade, the number of neurostimulator systems implanted in patients has been rapidly growing. Nearly 50, 000 neurostimulators are implanted worldwide annually. The most common type of implantable neurostimulators is indicated for pain relief. At the same time, commercial use of other electromagnetic technologies is expanding, making electromagnetic interference (EMI) of neurostimulator function an issue of concern. Typically reported sources of neurostimulator EMI include security systems, metal detectors and wireless equipment. When near such sources, patients with implanted neurostimulators have reported adverse events such as shock, pain, and increased stimulation. In recent in vitro studies, radio frequency identification (RFID) technology has been shown to inhibit the stimulation pulse of an implantable neurostimulator system during low frequency exposure at close distances. This could potentially be due to induced electrical currents inside the implantable neurostimulator leads that are caused by magnetic field coupling from the low frequency identification system. Methods To systematically address the concerns posed by EMI, we developed a test platform to assess the interference from coupled magnetic fields on implantable neurostimulator systems. To measure interference, we recorded the output of one implantable neurostimulator, programmed for best therapy threshold settings, when in close proximity to an operating low frequency RFID emitter. The output contained electrical potentials from the neurostimulator system and those induced by EMI from the RFID emitter. We also recorded the output of the same neurostimulator system programmed for best therapy threshold settings without RFID interference. Using the Spatially Extended Nonlinear Node (SENN) model, we compared threshold factors of spinal cord fiber excitation for both recorded outputs. Results The electric current induced by low frequency RFID emitter was not significant to have a noticeable effect on electrical stimulation. Conclusions We demonstrated a method for analyzing effects of coupled magnetic field interference on implantable neurostimulator system and its electrodes which could be used by device manufacturers during the design and testing phases of the development process. PMID:22014169

  8. Fabrication of FORTIS

    NASA Astrophysics Data System (ADS)

    McCandliss, Stephan R.; Fleming, Brian; Kaiser, Mary Elizabeth; Kruk, Jeffrey; Feldman, Paul D.; Kutyrev, Alexander S.; Li, Mary J.; Goodwin, Phillip A.; Rapchun, David; Lyness, Eric; Brown, Ari D.; Moseley, Harvey; Siegmund, Oswald; Vallerga, John

    2010-07-01

    The Johns Hopkins University sounding rocket group is building the Far-ultraviolet Off Rowland-circle Telescope for Imaging and Spectroscopy (FORTIS), which is a Gregorian telescope with rulings on the secondary mirror. FORTIS will be launched on a sounding rocket from White Sand Missile Range to study the relationship between Lyman alpha escape and the local gas-to-dust ratio in star forming galaxies with non-zero redshifts. It is designed to acquire images of a 30' x 30' field and provide fully redundant "on-the-fly" spectral acquisition of 43 separate targets in the field with a bandpass of 900 - 1800 Angstroms. FORTIS is an enabling scientific and technical activity for future cutting edge far- and near-uv survey missions seeking to: search for Lyman continuum radiation leaking from star forming galaxies, determine the epoch of He II reionization and characterize baryon acoustic oscillations using the Lyman forest. In addition to the high efficiency "two bounce" dual-order spectro-telescope design, FORTIS incorporates a number of innovative technologies including: an image dissecting microshutter array developed by GSFC; a large area (~ 45 mm x 170 mm) microchannel plate detector with central imaging and "outrigger" spectral channels provided by Sensor Sciences; and an autonomous targeting microprocessor incorporating commercially available field programable gate arrays. We discuss progress to date in developing our pathfinder instrument.

  9. CMOS Neurostimulation ASIC with 100 Channels, Scaleable Output, and Bidirectional Radio-Frequency Telemetry

    Microsoft Academic Search

    Gregg Jørgen Suaning; Nigel H. Lovell

    2001-01-01

    channel neurostimulation circuit comprising a complementary metal oxide semiconductor (CMOS), application- specific integrated circuit (ASIC) has been designed, constructed and tested. The ASIC forms a significant milestone and an integral compo- nent of a 100-electrode neurostimulation system being developed by the authors. The system comprises an externally worn transmitter and a body implantable stimulator. The purpose of the system is

  10. Chemical neurostimulation using pulse code modulation (PCM) microfluidic chips.

    PubMed

    Azizi, Farouk; Lu, Hui; Chiel, Hillel J; Mastrangelo, Carlos H

    2010-10-15

    We report the implementation of a chemical neurostimulation technique using microfluidic devices. The microfluidic chip in this research is used for the in vitro study of the nervous system of Aplysia californica under localized chemical stimulation. The polydimethylsiloxane (PDMS) device is a one-bit pulse code modulator that digitally controls the concentration of the non-hydrolysable cholinergic agonist carbachol injected directly above a ganglion. The chip was successful in repeatedly and controllably inducing bursts of ingestive-like patterns. The ability of the chip to induce rhythmic activity through the sheath of the ganglion suggests that it could serve as the basis for an implantable, in vivo device to control neural activity and motor behavior using chemical stimulation. PMID:20670654

  11. Chemical Neurostimulation Using Pulse Code Modulation (PCM) Microfluidic Chips

    PubMed Central

    Azizi, Farouk; Lu, Hui; Chiel, Hillel J.; Mastrangelo, Carlos H.

    2010-01-01

    We report the implementation of a chemical neurostimulation technique using microfluidic devices. The microfluidic chip in this research is used for the in vitro study of the nervous system of Aplysia californica under localized chemical stimulation. The polydimethylsiloxane (PDMS) device is a one-bit pulse code modulator that digitally controls the concentration of the non-hydrolysable cholinergic agonist carbachol injected directly above a ganglion. The chip was successful in repeatedly and controllably inducing bursts of ingestive-like patterns. The ability of the chip to induce rhythmic activity through the sheath of the ganglion suggests that it could serve as the basis for an implantable, in vivo device to control neural activity and motor behavior using chemical stimulation. PMID:20670654

  12. Neurostimulation. A promising therapeutic option for medically refractory epilepsy.

    PubMed

    Hassan, Ali; Al-Quliti, Khalid W

    2014-01-01

    Epilepsy is a common and serious chronic neurological disorder, affecting around 65 million people worldwide. Despite the advances in pharmacologic treatments for epilepsy, approximately 30% of the patients remain medically refractory and continue to have seizures on medications, in such cases, other treatment approaches are necessary. Resection surgery can be an alternative in many patients to achieve good seizure control; however, not all patients are suitable candidates for surgery. Electrical stimulation of the brain is a rapidly evolving therapy for patients with uncontrolled seizures despite the best medical and surgical treatment. Vagus nerve stimulation, deep brain stimulation of the anterior nucleus of thalamus, and responsive neurostimulation have class I evidence supporting their use in patients with intractable epilepsy. In this review, we discuss the evidence of these therapeutic modalities, their mechanism of action, efficacy, outcome, and their application in clinical use. PMID:24419442

  13. Assay of forties stream updated

    SciTech Connect

    Rhodes, A.K.

    1991-07-15

    This paper reports on characteristics of crude oil from the important North Sea Forties stream that have been updated. Forties oil field went on production in September 1975, operated by BP Exploration Co. Ltd. Since then, six other U.K. fields and Norway's Heimdal field have been tied into the system. Fields currently included in the stream are Forties; South, Central, and North Brae; Balmoral; Montrose/Arbroath; Buchan; and Heimdal. Production in the Forties filed peaked in 1978--81 at 500,000 b/d. By 1983, it had dropped to 447,000 b/d, and by March 1987, to about 400,000 b/d. Current production is about 200,000 b/d. The original pipeline was laid in 1973--74 from the Forties field in Block 21/10 of the North Sea's U.K. sector to the Cruden Bay terminal near Peterhead, Scotland.

  14. Methadone treatment at forty.

    PubMed

    Marion, Ira J

    2005-12-01

    In the view of a clinician who has been providing methadone therapy since its inception 40 years ago, the status of the treatment today reflects the culmination of two trends: an increase in understanding, skills, and standards on the one hand, and a deterioration of patients' health on the other. A retreat of stigma, greater physician interest, and the evolution of standards are beginning to move the treatment toward the mainstream. PMID:18552743

  15. Forty years of science and management on the Upper Mississippi River: an analysis of the past and a view of the future

    Microsoft Academic Search

    Richard E. Sparks

    2010-01-01

    The articles in this volume of Hydrobiologia commemorate the 40th anniversary of the Mississippi River Research Consortium\\u000a by synthesizing research and monitoring conducted on the river over the past 40 years. This article briefly describes the\\u000a recent history of development (since 1866) of the river and the programs that currently support monitoring, research, and\\u000a rehabilitation of the river. These programs have

  16. Neurostimulation as an intervention for treatment resistant depression: From research on mechanisms towards targeted neurocognitive strategies.

    PubMed

    De Raedt, Rudi; Vanderhasselt, Marie-Anne; Baeken, Chris

    2014-11-01

    Despite the fact that several interventions for major depression have proven efficacy, a substantial number of patients are or become treatment resistant to various forms of pharmacotherapy and psychotherapy. Biological interventions that directly target brain activity such as electroconvulsive therapy are used to treat these patients, but some of these interventions are unlikely to be easily accepted because of their more invasive nature or side-effects. The efficacy of non-invasive neurostimulation with a favorable side effect profile, such as repetitive Transcranial Magnetic Stimulation, could not be sufficiently demonstrated for treatment resistant depressed patients (TRD). We argue that research on the working mechanisms of these neurostimulation techniques is necessary to develop more efficient treatment protocols. After an overview of current neurostimulation approaches to treatment resistance and the introduction of a neurobiological and a cognitive framework of depression, we provide an integrative review of research on both the neurobiological and cognitive working mechanisms of neurostimulation in TRD, with a specific emphasis on the work of our lab. Thereafter, we describe our own studies and studies from other labs on new neurocognitive interventions. Finally we discuss how all this knowledge can be used to further develop new strategies to deal with treatment resistance, in combining neurostimulation and cognitive interventions. PMID:25468571

  17. Forty years of carabid beetle research in Europe - from taxonomy, biology, ecology and population studies to bioindication, habitat assessment and conservation.

    PubMed

    Kotze, D Johan; Brandmayr, Pietro; Casale, Achille; Dauffy-Richard, Emmanuelle; Dekoninck, Wouter; Koivula, Matti J; Lövei, Gábor L; Mossakowski, Dietrich; Noordijk, Jinze; Paarmann, Wilfried; Pizzolotto, Roberto; Saska, Pavel; Schwerk, Axel; Serrano, José; Szyszko, Jan; Taboada, Angela; Turin, Hans; Venn, Stephen; Vermeulen, Rikjan; Zetto, Tullia

    2011-01-01

    'Carabidologists do it all' (Niemelä 1996a) is a phrase with which most European carabidologists are familiar. Indeed, during the last half a century, professional and amateur entomologists have contributed enormously to our understanding of the basic biology of carabid beetles. The success of the field is in no small part due to regular European Carabidologists' Meetings, which started in 1969 in Wijster, the Netherlands, with the 14th meeting again held in the Netherlands in 2009, celebrating the 40th anniversary of the first meeting and 50 years of long-term research in the Dwingelderveld. This paper offers a subjective summary of some of the major developments in carabidology since the 1960s. Taxonomy of the family Carabidae is now reasonably established, and the application of modern taxonomic tools has brought up several surprises like elsewhere in the animal kingdom. Progress has been made on the ultimate and proximate factors of seasonality and timing of reproduction, which only exceptionally show non-seasonality. Triggers can be linked to evolutionary events and plausibly explained by the "taxon cycle" theory. Fairly little is still known about certain feeding preferences, including granivory and ants, as well as unique life history strategies, such as ectoparasitism and predation on higher taxa. The study of carabids has been instrumental in developing metapopulation theory (even if it was termed differently). Dispersal is one of the areas intensively studied, and results show an intricate interaction between walking and flying as the major mechanisms. The ecological study of carabids is still hampered by some unresolved questions about sampling and data evaluation. It is recognised that knowledge is uneven, especially concerning larvae and species in tropical areas. By their abundance and wide distribution, carabid beetles can be useful in population studies, bioindication, conservation biology and landscape ecology. Indeed, 40 years of carabidological research have provided so much data and insights, that among insects - and arguably most other terrestrial organisms - carabid beetles are one of the most worthwhile model groups for biological studies. PMID:21738408

  18. Development of genetics in the world and in Croatia--forty years of the Croatian Society of Human Genetics of the Croatian Medical Association.

    PubMed

    Zergollern-?upak, Ljiljana; Bariši?, Ingeborg; Moronin Pohovski, Leona

    2014-09-01

    Resulting from several basic scientific disciplines, genetics has made impressive progress in the last century by discoveries of the heredity rules and genome structure, and by identification of the genes that determine the occurrence and characteristics of human diseases. In Croatia, the development of genetics began in the middle of the past century by the pioneering work of clinicians and basic scientists, which resulted in significant development of this scientific discipline that has quickly found its practical application in clinical genetics-cytogenetics, molecular genetics and prenatal diagnosis. The rapid advancement of technology and knowledge of genetics in recent decades has led to the development of genomics and related disciplines, entering the revolutionary new era of personalized medicine. Currently, much more data can be collected than interpreted. The data of electronic medical records, genomics, epigenetics, proteomics, meta- bolomics and microbiomics should be integrated and interpreted at the level of individual genome. Extensive use of new information will open a range of ethical issues that we must face timely. It is expected that in the forthcoming years, we will be able to learn more about genetics than what we have learned throughout the history of medicine. We must be prepared to welcome this new knowledge, reflecting on the positive and negative aspects of the latest achievements in the field ofgenetics. We hope that the experts dealing with human genetics in Croatia will successfully continue their work to enable practical application of the latest achievements in genetics, expanding our understanding of the concept of health and disease. PMID:25420360

  19. Advanced technologies and novel neurostimulation targets in trigeminal autonomic cephalalgias.

    PubMed

    Lambru, Giorgio; Giakoumakis, Emmanouil; Al-Kaisy, Adnan

    2015-05-01

    The trigeminal autonomic cephalalgias (TACs) are a group of rare but disabling primary headache disorders. Their management is challenging, since only few effective treatments are available and high doses may be required to control the headache, compromising patients' adherence to treatments. A significant minority of patients, who fail to respond to or tolerate established treatments, are left with enormous level of disability and disruption to their quality of life. A growing body of evidence demonstrates the efficacy of central and peripheral neuromodulation approaches for management of patients with refractory TACs. In view of the potential risks related to deep brain stimulation of the posterior hypothalamic region, occipital nerve stimulation is currently considered the first treatment option for refractory chronic TACs. However, in view of the presence of paraesthesia induced by the stimulator, no robust controlled trials have been possible so far. Additionally, the equipment used for occipital nerve stimulation is not designed specifically for peripheral nerve stimulation, thus a significant proportion of patients experience device-related complications that often require surgical revisions. To overcome these issues, new neurostimulation technologies using less invasive or non-invasive approaches and modulating different neuroanatomical targets have been recently studied. PMID:26017527

  20. Modulating the pain network--neurostimulation for central poststroke pain.

    PubMed

    Hosomi, Koichi; Seymour, Ben; Saitoh, Youichi

    2015-05-01

    Central poststroke pain (CPSP) is one of the most under-recognized consequences of stroke, occurring in up to 10% of patients, and is also one of the most difficult to treat. The condition characteristically develops after selective lesions to the spinothalamic system, most often to the ventral posterior thalamus. Here, we suggest that CPSP is best characterized as a disorder of brain network reorganization, and that this characterization offers insight into the inadequacy of most current pharmacological treatments. Accordingly, we review the progress in identification of nonpharmacological treatments, which could ultimately lead to mechanism-based therapeutics. Of the invasive neurostimulation treatments available, electrical motor cortex stimulation seems to be superior to deep brain stimulation of the thalamus or brainstem, but enthusiasm for clinical use of the procedure is limited by its invasiveness. The current preference is for noninvasive transcranial magnetic stimulation, which, though effective, requires repeated application, causing logistical difficulties. Although CPSP is often severe and remains difficult to treat, future characterization of the precise underlying neurophysiological mechanisms, together with technological innovation, should allow new treatments to evolve. PMID:25896085

  1. Neurostimulation in Alzheimer's disease: from basic research to clinical applications.

    PubMed

    Nardone, Raffaele; Höller, Yvonne; Tezzon, Frediano; Christova, Monica; Schwenker, Kerstin; Golaszewski, Stefan; Trinka, Eugen; Brigo, Francesco

    2015-05-01

    The development of different methods of brain stimulation provides a promising therapeutic tool with potentially beneficial effects on subjects with impaired cognitive functions. We performed a systematic review of the studies published in the field of neurostimulation in Alzheimer's disease (AD), from basic research to clinical applications. The main methods of non-invasive brain stimulation are repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Preliminary findings have suggested that both techniques can enhance performances on several cognitive functions impaired in AD. Another non-invasive emerging neuromodulatory approach, the transcranial electromagnetic treatment, was found to reverse cognitive impairment in AD transgenic mice and even improves cognitive performance in normal mice. Experimental studies suggest that high-frequency electromagnetic fields may be critically important in AD prevention and treatment through their action at mitochondrial level. Finally, the application of a widely known invasive technique, the deep brain stimulation (DBS), has increasingly been considered as a therapeutic option also for patients with AD; it has been demonstrated that DBS of fornix/hypothalamus and nucleus basalis of Meynert might improve or at least stabilize cognitive functioning in AD. Initial encouraging results provide support for continuing to investigate non-invasive and invasive brain stimulation approaches as an adjuvant treatment for AD patients. PMID:25721941

  2. Neurostimulation to improve level of consciousness in patients with epilepsy.

    PubMed

    Gummadavelli, Abhijeet; Kundishora, Adam J; Willie, Jon T; Andrews, John P; Gerrard, Jason L; Spencer, Dennis D; Blumenfeld, Hal

    2015-06-01

    When drug-resistant epilepsy is poorly localized or surgical resection is contraindicated, current neurostimulation strategies such as deep brain stimulation and vagal nerve stimulation can palliate the frequency or severity of seizures. However, despite medical and neuromodulatory therapy, a significant proportion of patients continue to experience disabling seizures that impair awareness, causing disability and risking injury or sudden unexplained death. We propose a novel strategy in which neuromodulation is used not only to reduce seizures but also to ameliorate impaired consciousness when the patient is in the ictal and postictal states. Improving or preventing alterations in level of consciousness may have an effect on morbidity (e.g., accidents, drownings, falls), risk for death, and quality of life. Recent studies may have elucidated underlying networks and mechanisms of impaired consciousness and yield potential novel targets for neuromodulation. The feasibility, benefits, and pitfalls of potential deep brain stimulation targets are illustrated in human and animal studies involving minimally conscious/vegetative states, movement disorders, depth of anesthesia, sleep-wake regulation, and epilepsy. We review evidence that viable therapeutic targets for impaired consciousness associated with seizures may be provided by key nodes of the consciousness system in the brainstem reticular activating system, hypothalamus, basal ganglia, thalamus, and basal forebrain. PMID:26030698

  3. Forty Years of Research on Isolated Galaxies

    Microsoft Academic Search

    J. Sulentic

    2010-01-01

    Isolated galaxies have not been a hot topic over the past four decades. This is partly due to uncertainties about their existence. Are there galaxies isolated enough to be interesting? Do they exist in sufficient numbers to be statistically useful? Most attempts to compile isolated galaxy lists were marginally successful-too small number and not very isolated galaxies. If really isolated

  4. Forty Years of Research on Isolated Galaxies

    Microsoft Academic Search

    J. W. Sulentic

    2009-01-01

    Isolated galaxies have not been a hot topic over the past four decades. This\\u000ais partly due to uncertainties about their existence. Are there galaxies\\u000aisolated enough to be interesting? Do they exist in sufficient numbers to be\\u000astatistically useful? Most attempts to compile isolated galaxy lists were\\u000amarginally successful--too small number and not very isolated galaxies. If\\u000areally isolated

  5. FORTY-SEVENTH DOCTORAL COMMENCEMENT

    E-print Network

    Dennehy, John

    for doctoral education--know intimately the joys of a stunning public higher education. Thus in gratitude, Urban Education, Liberal Studies, and Women's Studies, CUNY Graduate Center THE GRADUATE CENTER THE CITY, representing forty-one countries including China, Romania, Burma, Congo, and Colombia, and also the Bronx

  6. 1024-Channel-Scalable Wireless Neuromonitoring and Neurostimulation Rodent Headset with

    E-print Network

    Genov, Roman

    , Canada Abstract--We present a compact wireless headset system for simultaneous multi-site neural-controller and a ZigBee wireless transceiver. The system is built by parallelizing up to four 0.35µm CMOS integrated circuits (each having 256 neural amplifiers and 64 neurostimulators) to provide a total maximum of 1024

  7. Impact of brain tissue filtering on neurostimulation fields: a modeling study

    PubMed Central

    Wagner, Tim; Eden, Uri; Rushmore, Jarrett; Russo, Christopher J.; Dipietro, Laura; Fregni, Felipe; Simon, Stephen; Rotman, Stephen; Pitskel, Naomi B.; Ramos-Estebanez, Ciro; Pascual-Leone, Alvaro; Grodzinsky, Alan J.; Zahn, Markus; Valero-Cabre, Antoni

    2013-01-01

    Electrical neurostimulation techniques, such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS), are increasingly used in the neurosciences, e.g., for studying brain function, and for neurotherapeutics, e.g., for treating depression, epilepsy, and Parkinson’s disease. The characterization of electrical properties of brain tissue has guided our fundamental understanding and application of these methods, from electrophysiologic theory to clinical dosing-metrics. Nonetheless, prior computational models have primarily relied on ex-vivo impedance measurements. We recorded the in-vivo impedances of brain tissues during neurosurgical procedures and used these results to construct MRI guided computational models of TMS and DBS neurostimulatory fields and conductance-based models of neurons exposed to stimulation. We demonstrated that tissues carry neurostimulation currents through frequency dependent resistive and capacitive properties not typically accounted for by past neurostimulation modeling work. We show that these fundamental brain tissue properties can have significant effects on the neurostimulatory-fields (capacitive and resistive current composition and spatial/temporal dynamics) and neural responses (stimulation threshold, ionic currents, and membrane dynamics). These findings highlight the importance of tissue impedance properties on neurostimulation and impact our understanding of the biological mechanisms and technological potential of neurostimulatory methods. PMID:23850466

  8. [The effectiveness of the application of dynamic electrical neurostimulation for the treatment of dorsalgias of the lumbar-sacral localization].

    PubMed

    Chernysh, I M; Vasilenko, A M

    2015-01-01

    Dynamic electrical neurostimulation (DENS) is a variant of transcutaneous electrical neurostimulation based on the use of biological feedback monitoring the surface impedance of the skin. The present study was designed to estimate the effectiveness of the application of dynamic electrical neurostimulation for the treatment of dorsalgias of the lumbar-sacral localization in comparison with the standard combined treatment including pharmacotherapy, massage, and therapeutic physical culture exercises. The data obtained indicate that the inclusion of DENS in the standard treatment protocol promotes the regression of pain and neurological symptoms; moreover, it accelerates the achievement of clinical remission. PMID:26036082

  9. Fabrication and Calibration of FORTIS

    NASA Technical Reports Server (NTRS)

    Fleming, Brian T.; McCandliss, Stephan R.; Kaiser, Mary Elizabeth; Kruk, Jeffery; Feldman, Paul D.; Kutyrev, Alexander S.; Li, Mary J.; Rapchun, David A.; Lyness, Eric; Moseley, S. H.; Siegmund, Oswald; Vallerga, John; Martin, Adrian

    2011-01-01

    The Johns Hopkins University sounding rocket group is entering the final fabrication phase of the Far-ultraviolet Off Rowland-circle Telescope for Imaging and Spectroscopy (FORTIS); a sounding rocket borne multi-object spectro-telescope designed to provide spectral coverage of 43 separate targets in the 900 - 1800 Angstrom bandpass over a 30' x 30' field-of-view. Using "on-the-fly" target acquisition and spectral multiplexing enabled by a GSFC microshutter array, FORTIS will be capable of observing the brightest regions in the far-UV of nearby low redshift (z approximately 0.002 - 0.02) star forming galaxies to search for Lyman alpha escape, and to measure the local gas-to-dust ratio. A large area (approximately 45 mm x 170 mm) microchannel plate detector built by Sensor Sciences provides an imaging channel for targeting flanked by two redundant spectral outrigger channels. The grating is ruled directly onto the secondary mirror to increase efficiency. In this paper, we discuss the recent progress made in the development and fabrication of FORTIS, as well as the results of early calibration and characterization of our hardware, including mirror/grating measurements, detector performance, and early operational tests of the micro shutter arrays.

  10. Demonstration and characterization of hippocampal cholinergic neurostimulating peptide (HCNP) processing enzyme activity in rat hippocampus

    Microsoft Academic Search

    Yasushi Otsuka; Kosei Ojika

    1996-01-01

    Hippocampal cholinergic neurostimulating peptide (HCNP) stimulates cholinergic activity of cultured medial septal nuclei explants.\\u000a It consists of eleven amino acids that are located at the N-terminal region of its precursor protein. This report concerns\\u000a the demonstration and characterization of an HCNP processing enzyme that cleaves the bioactive undecapeptide from the precursor.\\u000a The enzyme was purified from the hippocampus of young

  11. Pre-frontal control of closed-loop limbic neurostimulation by rodents using a brain-computer interface

    PubMed Central

    Widge, Alik S.; Moritz, Chet T.

    2015-01-01

    Objective There is great interest in closed-loop neurostimulators that sense and respond to a patient’s brain state. Such systems may have value for neurological and psychiatric illnesses where symptoms have high intraday variability. Animal models of closed-loop stimulators would aid preclinical testing. We sought to demonstrate that rodents can directly control a closed-loop limbic neurostimulator via a brain-computer interface (BCI). Approach We trained rats to use an auditory BCI controlled by single units in prefrontal cortex (PFC). The BCI controlled electrical stimulation in the medial forebrain bundle (MFB), a limbic structure involved in reward-seeking. Rigorous offline analyses were performed to confirm volitional control of the neurostimulator. Main Results All animals successfully learned to use the BCI and neurostimulator, with closed-loop control of this challenging task demonstrated at 80% of PFC recording locations. Analysis across sessions and animals confirmed statistically robust BCI control and specific, rapid modulation of PFC activity. Significance Our results provide a preliminary demonstration of a method for emotion-regulating closed-loop neurostimulation. They further suggest that activity in prefrontal cortex can be used to control a BCI without pre-training on a predicate task. This offers the potential for BCI-based treatments in refractory neurological and mental illness. PMID:24608127

  12. Toward a fully integrated neurostimulator with inductive power recovery front-end.

    PubMed

    Mounaïm, Fayçal; Sawan, Mohamad

    2012-08-01

    In order to investigate new neurostimulation strategies for micturition recovery in spinal cord injured patients, custom implantable stimulators are required to carry-on chronic animal experiments. However, higher integration of the neurostimulator becomes increasingly necessary for miniaturization purposes, power consumption reduction, and for increasing the number of stimulation channels. As a first step towards total integration, we present in this paper the design of a highly-integrated neurostimulator that can be assembled on a 21-mm diameter printed circuit board. The prototype is based on three custom integrated circuits fabricated in High-Voltage (HV) CMOS technology, and a low-power small-scale commercially available FPGA. Using a step-down approach where the inductive voltage is left free up to 20 V, the inductive power and data recovery front-end is fully integrated. In particular, the front-end includes a bridge rectifier, a 20-V voltage limiter, an adjustable series regulator (5 to 12 V), a switched-capacitor step-down DC/DC converter (1:3, 1:2, or 2:3 ratio), as well as data recovery. Measurements show that the DC/DC converter achieves more than 86% power efficiency while providing around 3.9-V from a 12-V input at 1-mA load, 1:3 conversion ratio, and 50-kHz switching frequency. With such efficiency, the proposed step-down inductive power recovery topology is more advantageous than its conventional step-up counterpart. Experimental results confirm good overall functionality of the system. PMID:23853175

  13. Neurostimulation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Disease in Rat Collagen-Induced Arthritis

    PubMed Central

    Levine, Yaakov A.; Koopman, Frieda A.; Faltys, Michael; Caravaca, April; Bendele, Alison; Zitnik, Ralph; Vervoordeldonk, Margriet J.; Tak, Paul Peter

    2014-01-01

    Introduction The inflammatory reflex is a physiological mechanism through which the nervous system maintains immunologic homeostasis by modulating innate and adaptive immunity. We postulated that the reflex might be harnessed therapeutically to reduce pathological levels of inflammation in rheumatoid arthritis by activating its prototypical efferent arm, termed the cholinergic anti-inflammatory pathway. To explore this, we determined whether electrical neurostimulation of the cholinergic anti-inflammatory pathway reduced disease severity in the collagen-induced arthritis model. Methods Rats implanted with vagus nerve cuff electrodes had collagen-induced arthritis induced and were followed for 15 days. Animals underwent active or sham electrical stimulation once daily from day 9 through the conclusion of the study. Joint swelling, histology, and levels of cytokines and bone metabolism mediators were assessed. Results Compared with sham treatment, active neurostimulation of the cholinergic anti-inflammatory pathway resulted in a 52% reduction in ankle diameter (p?=?0.02), a 57% reduction in ankle diameter (area under curve; p?=?0.02) and 46% reduction overall histological arthritis score (p?=?0.01) with significant improvements in inflammation, pannus formation, cartilage destruction, and bone erosion (p?=?0.02), accompanied by numerical reductions in systemic cytokine levels, not reaching statistical significance. Bone erosion improvement was associated with a decrease in serum levels of receptor activator of NF-?B ligand (RANKL) from 132±13 to 6±2 pg/mL (mean±SEM, p?=?0.01). Conclusions The severity of collagen-induced arthritis is reduced by neurostimulation of the cholinergic anti-inflammatory pathway delivered using an implanted electrical vagus nerve stimulation cuff electrode, and supports the rationale for testing this approach in human inflammatory disorders. PMID:25110981

  14. Réflexion sur l’intérêt médicoéconomique des boîtiers de neurostimulation Restore ® et Itrel ® dans le traitement des douleurs neuropathiques chroniques

    Microsoft Academic Search

    A. Simonneau; S. d’Houtaud; M. Djabarouti; J.-P. Giot; J. Magnam; B. Bataille; F. Lapierre; P. Rigoard

    2009-01-01

    In 2007, four patients where implanted with the Restore® neurostimulation system for intractable chronic leg pain at the Poitiers Hospital. The potential for improving the patients’ quality of life and medical-economic concerns motivated this choice for these highly selected patients. In this paper, we propose brief clinical case reports and discuss the reasons for choosing this new rechargeable system, even

  15. The IEEE Oceanic Engineering Society at Forty: The Challenges of an Evolving Society

    Microsoft Academic Search

    Stanley G. Chamberlain; Joseph Czika; Norman D. Miller; Glen N. Williams

    2008-01-01

    The IEEE oceanic engineering society (OES) has completed forty years of active engagement: the initial eight years in the form of the oceanography coordinating committee (OCC), followed by seven years as the council of oceanic engineering (COE), then the past twenty-five years in the form of an IEEE society. During those forty years, the OCC\\/COE\\/OES has existed to serve society,

  16. High cervical epidural neurostimulation for post-traumatic headache management.

    PubMed

    Elahi, Foad; Reddy, Chandan

    2014-01-01

    Headache following head injuries has been reported for centuries. The majority of post-traumatic headache (PTH) patients will report resolution of their complaints within a few months from the time of the initial injury. PTHs can contribute to disability, lost productivity, and health care costs. In this article we discuss a 40-year-old male with a history of motor vehicle accident and basal skull fracture. The patient had no headache history prior to the accident. He presented with more than 3 years persistent daily headache. The patient described constant throbbing and stabbing quality headaches predominantly on the left hemicranium with constant facial pain. He denies having aura, nausea, or vomiting, but reported occasional neck tightness. An extensive workup was carried out under the direction of the patient's primary neurologist. Secondary to persistent intractable pain, the patient was referred to the pain clinic for further evaluation. As his headaches were resistant to all trialed strategies, we decided to turn our therapeutic focus toward electrical neuromodulation along with continuing multimodal medications and multidisciplinary approach. During 7 days of high cervical dorsal column electrical nerve stimulation trial, he reported almost 90% pain reduction and significant improvement on his quality of life. On 12 months follow-up after he underwent a permanent implant of high cervical dorsal column electrical nerve stimulation, he reported the same level of pain reduction along with 100% satisfaction rate. To the best of our knowledge, there have been no publications to date concerning the application of high cervical nerve stimulation for PTH. PMID:25054404

  17. Calibration and flight qualification of FORTIS

    NASA Astrophysics Data System (ADS)

    Fleming, Brian T.; McCandliss, Stephan R.; Redwine, Keith; Kaiser, Mary Elizabeth; Kruk, Jeffery; Feldman, Paul D.; Kutyrev, Alexander S.; Li, Mary J.; Moseley, S. H.; Siegmund, Oswald; Vallerga, John; Martin, Adrian

    2013-09-01

    The Johns Hopkins University sounding rocket group has completed the assembly and calibration of the Far-ultraviolet Off Rowland-circle Telescope for Imaging and Spectroscopy (FORTIS); a sounding rocket borne multi-object spectro-telescope designed to provide spectral coverage of up to 43 separate targets in the 900 - 1800 Angstrom bandpass over a 30' x 30' field-of-view. FORTIS is capable of selecting the far-UV brightest regions of the target area by utilizing an autonomous targeting system. Medium resolution (R ~ 400) spectra are recorded in redundant dual-order spectroscopic channels with ~40 cm2 of effective area at 1216 Å. The maiden launch of FORTIS occurred on May 10, 2013 out of the White Sands Missile Range, targeting the extended spiral galaxy M61 and nearby companion NGC 4301. We report on the final flight calibrations of the instrument, as well as the flight results.

  18. A microscale photovoltaic neurostimulator for fiber optic delivery of functional electrical stimulation

    NASA Astrophysics Data System (ADS)

    Song, Yoon-Kyu; Stein, John; Patterson, William R.; Bull, Christopher W.; Davitt, Kristina M.; Serruya, Mijail D.; Zhang, Jiayi; Nurmikko, Arto V.; Donoghue, John P.

    2007-09-01

    Recent advances in functional electrical stimulation (FES) show significant promise for restoring voluntary movement in patients with paralysis or other severe motor impairments. Current approaches for implantable FES systems involve multisite stimulation, posing research issues related to their physical size, power and signal delivery, surgical and safety challenges. To explore a different means for delivering the stimulus to a distant muscle nerve site, we have elicited in vitro FES response using a high efficiency microcrystal photovoltaic device as a neurostimulator, integrated with a biocompatible glass optical fiber which forms a lossless, interference-free lightwave conduit for signal and energy transport. As a proof of concept demonstration, a sciatic nerve of a frog is stimulated by the microcrystal device connected to a multimode optical fiber (core diameter of 62.5 µm), which converts optical activation pulses (~100 µs) from an infrared semiconductor laser source (at 852 nm wavelength) into an FES signal.

  19. An Arbitrary Waveform Wearable Neuro-stimulator System for Neurophysiology Research on Freely Behaving Animals.

    PubMed

    Samani, Mohsen Mosayebi; Mahnam, Amin; Hosseini, Nasrin

    2014-04-01

    Portable wireless neuro-stimulators have been developed to facilitate long-term cognitive and behavioral studies on the central nervous system in freely moving animals. These stimulators can provide precisely controllable input(s) to the nervous system, without distracting the animal attention with cables connected to its body. In this study, a low power backpack neuro-stimulator was developed for animal brain researches that can provides arbitrary stimulus waveforms for the stimulation, while it is small and light weight to be used for small animals including rats. The system consists of a controller that uses an RF link to program and activate a small and light microprocessor-based stimulator. A Howland current source was implemented to produce precise current controlled arbitrary waveform stimulations. The system was optimized for ultra-low power consumption and small size. The stimulator was first tested for its electrical specifications. Then its performance was evaluated in a rat experiment when electrical stimulation of medial longitudinal fasciculus induced circling behavior. The stimulator is capable of delivering programmed stimulations up to ± 2 mA with adjusting steps of 1 ?A, accuracy of 0.7% and compliance of 6 V. The stimulator is 15 mm × 20 mm × 40 mm in size, weights 13.5 g without battery and consumes a total power of only 5.l mW. In the experiment, the rat could easily carry the stimulator and demonstrated the circling behavior for 0.1 ms current pulses of above 400 ?A. The developed system has a competitive size and weight, whereas providing a wide range of operation and the flexibility of generating arbitrary stimulation patterns ideal for long-term experiments in the field of cognitive and neuroscience research. PMID:24761373

  20. An Arbitrary Waveform Wearable Neuro-stimulator System for Neurophysiology Research on Freely Behaving Animals

    PubMed Central

    Samani, Mohsen Mosayebi; Mahnam, Amin; Hosseini, Nasrin

    2014-01-01

    Portable wireless neuro-stimulators have been developed to facilitate long-term cognitive and behavioral studies on the central nervous system in freely moving animals. These stimulators can provide precisely controllable input(s) to the nervous system, without distracting the animal attention with cables connected to its body. In this study, a low power backpack neuro-stimulator was developed for animal brain researches that can provides arbitrary stimulus waveforms for the stimulation, while it is small and light weight to be used for small animals including rats. The system consists of a controller that uses an RF link to program and activate a small and light microprocessor-based stimulator. A Howland current source was implemented to produce precise current controlled arbitrary waveform stimulations. The system was optimized for ultra-low power consumption and small size. The stimulator was first tested for its electrical specifications. Then its performance was evaluated in a rat experiment when electrical stimulation of medial longitudinal fasciculus induced circling behavior. The stimulator is capable of delivering programmed stimulations up to ± 2 mA with adjusting steps of 1 ?A, accuracy of 0.7% and compliance of 6 V. The stimulator is 15 mm × 20 mm × 40 mm in size, weights 13.5 g without battery and consumes a total power of only 5.l mW. In the experiment, the rat could easily carry the stimulator and demonstrated the circling behavior for 0.1 ms current pulses of above 400 ?A. The developed system has a competitive size and weight, whereas providing a wide range of operation and the flexibility of generating arbitrary stimulation patterns ideal for long-term experiments in the field of cognitive and neuroscience research. PMID:24761373

  1. Sixty Hertz Neurostimulation Amplifies Subthalamic Neural Synchrony in Parkinson’s Disease

    PubMed Central

    Blumenfeld, Zack; Velisar, Anca; Miller Koop, Mandy; Hill, Bruce C.; Shreve, Lauren A.; Quinn, Emma J.; Kilbane, Camilla; Yu, Hong; Henderson, Jaimie M.; Brontë-Stewart, Helen

    2015-01-01

    High frequency subthalamic nucleus (STN) deep brain stimulation (DBS) improves the cardinal motor signs of Parkinson’s disease (PD) and attenuates STN alpha/beta band neural synchrony in a voltage-dependent manner. While there is a growing interest in the behavioral effects of lower frequency (60 Hz) DBS, little is known about its effect on STN neural synchrony. Here we demonstrate for the first time that during intra-operative 60 Hz STN DBS, one or more bands of resting state neural synchrony were amplified in the STN in PD. We recorded intra-operative STN resting state local field potentials (LFPs) from twenty-eight STNs in seventeen PD subjects after placement of the DBS lead (model 3389, Medtronic, Inc.) before and during three randomized neurostimulation sets (130 Hz/1.35V, 130 Hz/2V, 60 Hz/2V). During 130 Hz/2V DBS, baseline (no DBS) STN alpha (8 – 12 Hz) and beta (13 – 35 Hz) band power decreased (N=14, P < 0.001 for both), whereas during 60 Hz/2V DBS, alpha band and peak frequency power increased (P = 0.012, P = 0.007, respectively). The effect of 60 Hz/2V DBS opposed that of power-equivalent (130 Hz/1.35V) DBS (alpha: P < 0.001, beta: P = 0.006). These results show that intra-operative 60 Hz STN DBS amplified whereas 130 Hz STN DBS attenuated resting state neural synchrony in PD; the effects were frequency-specific. We demonstrate that neurostimulation may be useful as a tool to selectively modulate resting state resonant bands of neural synchrony and to investigate its influence on motor and non-motor behaviors in PD and other neuropsychiatric diseases. PMID:25807463

  2. Cardiac nociception in rats: neuronal pathways and the influence of dermal neurostimulation on conveyance to the central nervous system.

    PubMed

    Albutaihi, Ibrahim A M; Hautvast, Raymond W M; DeJongste, Mike J L; Ter Horst, Gert J; Staal, Michiel J

    2003-02-01

    Neurostimulation for refractory angina pectoris is often advocated for its clinical efficacy. However, the recruited pathways to induce electroanalgesia are partially unknown. Therefore, we sought to study the effect of neurostimulation on experimentally induced cardiac nociception, using capsaicin as nociception-induced substance. Four different groups of male Wistar rats were pericardially infused with either saline or capsaicin with or without neurostimulation. Group StimCap was infused with capsaicin, and group StimVeh was infused with saline. Both groups were treated with neurostimulation. Group ShamCap was only infused with capsaicin without stimulation, whereas group ShamVeh was only infused with saline. Neuronal activation differences were assessed with cytochemical staining, revealing the cellular expression of c-fos. Pain behavior was registered on video and was quantitatively analyzed. In the StimCap and ShamCap groups, all animals exerted typical pain behavior, whereas in the StimVeh group only moderate changes in behavior were observed. Group ShamVeh animals were unaffected by the procedure. The upper thoracic spinal cord showed high numbers of c-fos-positive cells, predominantly in laminae III and IV in both StimCap and StimVeh groups. Almost no c-fos expression was noticed in groups ShamCap and ShamVeh in these sections of the spinal cord. In groups StimCap and ShamCap a significantly higher number of c-fos-positive cells in comparison with groups StimVeh and ShamVeh were noticed in the periambigus region, the nucleus tractus solitarius, and the paraventricular hypothalamus. In the paraventricular thalamus, periaqueductal gray, and central amygdala, no significant differences were noticed among the first three groups, and the c-fos concentration in these three groups was significantly higher than in group ShamVeh. It is concluded that neurostimulation does not influence capsaicin-induced cardiac nociceptive pain pulses to the central nervous system. Furthermore, capsaicin-induced cardiac pain and neurostimulation may utilize two different pathways. PMID:12663934

  3. Path Integration in Desert Ants, Cataglyphis fortis

    Microsoft Academic Search

    Martin Muller; Rudiger Wehner

    1988-01-01

    Foraging desert ants, Cataglyphis fortis, continually keep track of their own positions relative to home--i.e., integrate their tortuous outbound routes and return home along straight (inbound) routes. By experimentally manipulating the ants' outbound trajectories we show that the ants solve this path integration problem not by performing a true vector summation (as a human navigator does) but by employing a

  4. Forty-eighth annual power distribution conference

    SciTech Connect

    NONE

    1995-12-31

    This book contains papers presented at the Forty-eighth Annual Power Distribution Conference held in 1995 at Austin, Texas. The topics of the papers include power quality in power distribution systems, methods to improve power quality, power system communications, automation of distribution systems, distributed data acquisition, energy efficiency in industrial plants, weather data in operation of distribution systems, detection and location of failed or failing equipment in power distribution systems, lightning and overvoltage protection, distribution cable research update, and equipment protection devices for residential power distribution systems.

  5. Forty years of Galilean Electromagnetism (1973-2013)

    NASA Astrophysics Data System (ADS)

    Rousseaux, Germain

    2013-08-01

    We review Galilean Electromagnetism since the 1973 seminal paper of Jean-Marc Lévy-Leblond and Michel Le Bellac and we explain for the first time all the historical experiments of Rowland, Vasilescu Karpen, Roentgen, Eichenwald, Wilson, Wilson and Wilson, which were previously interpreted in a Special Relativistic framework by showing the uselessness of the latter for setups involving slow motions of a part of the apparatus. Galilean Electromagnetism is not an alternative to Special Relavity but is precisely its low-velocity limit in Classical Electromagnetism.

  6. After Forty Years: The Other Half of the Puzzle.

    ERIC Educational Resources Information Center

    Murphy, John A.

    1995-01-01

    Although many school districts are integrated, integration has not had the anticipated effect on minority achievement promised by "Brown v. Board of Education of Topeka, Kansas." The article discusses the positive effects of aggressive strategies for minority students, and it suggests shifting the burden of social integration to the community. (SM)

  7. Forty Years of Teacher Education in Australia: 1974-2014

    ERIC Educational Resources Information Center

    Mayer, Diane

    2014-01-01

    In this paper, I analyse the history of teacher education in Australia from 1974 to the current policy moment in which questions are increasingly being asked about the quality of teaching and teacher education. Teacher education is, and has been, a highly scrutinised domain in Australia. Since the 1970s, we have seen more than 100 reviews of…

  8. Closing the Gap: Forty Years of Economic Progress for Blacks.

    ERIC Educational Resources Information Center

    Smith, James P.; Welch, Finis R.

    This report presents the findings on the long-term economic progress of American blacks. The report consists of seven sections. The first is a general introduction. Section 2 describes major changes in the racial wage gap for males from 1940 to 1980 and identifies the distribution of wage gains among important subgroups in the black population.…

  9. Changes in Patterns of Health Care: Plus Forty Years

    ERIC Educational Resources Information Center

    Sofalvi, Alan J.

    2010-01-01

    In this article, the author presents an update of Herman's article ["Changes in Patterns of Health Care," "School Health Review," 1(9-14)1969] that focuses on the changes in patterns of health care. He discusses the poverty, insurance, and access to medical care as well as the quality of medical care for adults and minors. He stresses that…

  10. Forty-Year-Old Foam Springs Back With New Benefits

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The most recognized and widely used NASA spinoff is at it again. Temper foam, whose origins date back to 1966 when it was developed to absorb shock and, thus, offer improved protection and comfort in NASA s airplane seats, has paid its dividends to Earth repeatedly, and in many different ways. It has padded the helmets of the Dallas Cowboys throughout the 1970s and 1980s, protected bedridden patients from bedsores, and comforted the feet of thousands wearing stylish shoes that incorporate the cushioning material in their insoles. Four decades later, the world has come to realize that there are no bounds to temper foam s benefits. Though the rights to the technology have been shared amongst various manufacturers, the original product maker is still going strong, pushing temper foam into new arenas, including automotives, amusement parks, prosthetics, and modern art.

  11. Forty years of carabid beetle research in Europe 55 Forty years of carabid beetle research in Europe from

    E-print Network

    Boyer, Edmond

    in Europe ­ from taxonomy, biology, ecology and population studies to bioindication, habitat assessment University of Calabria, Department of Ecology, Ponte Bucci, I-87036 Rende (CS), Italy 3 Università di Sassari/Atzenhausen, Germany 11 Czech University of Life Sciences in Prague, Department of Ecology, Kamycka 129, CZ-165 21

  12. Systematic analysis and experiment of inductive coupling and induced voltage for inductively coupled wireless implantable neurostimulator application

    NASA Astrophysics Data System (ADS)

    Xue, Ning; Cho, Sung-Hoon; Chang, Sung-Pil; Lee, Jeong-Bong

    2012-07-01

    The main strategy for wireless power transfer to implantable devices is to use inductive coupling technology. The induced voltage of implanted devices highly depends on factors such as mutual inductance between the external transmitter coil and the receiver coil, quality factor of the receiver circuit and operation frequency. In this paper, the mutual inductance under a variety of geometries of external coil and under the condition of different vertical distances, lateral displacements and angular misalignments between two coils were theoretically calculated and simulated. To ascertain the condition of maximum power transmission for certain coils’ position requirements, an LC tank (2.7 mm × 2 mm) consisting of a microfabricated gold inductor coil and a small surface mounted capacitor was designed and fabricated as the telemetric part of a neurostimulator. The induced voltage of the LC tank was measured in both air and artificial tissue media under different sizes of power coil and operation frequencies. As a result, the optimum size of a transmitter coil is selected to be of 4 mm inner radius with six turns of coil, while the whole coupling system operates at 94 MHz resonant frequency within 5-11 mm vertical distance, 0-4 mm lateral and 0°-50° angular misalignment between two coils. With the change of the above coils’ positions, the measured induced voltage drops within 30%, satisfying the surgical requirement for neurostimulator implantation.

  13. An Evaluation of the Brachial Plexus Block at the Humeral Canal Using a Neurostimulator (1417 Patients): The Efficacy, Safety, and Predictive Criteria of Failure

    Microsoft Academic Search

    Michel Carles; Alphonse Pulcini; Philippe Macchi; Patrick Duflos; Marc Raucoules-Aime; Dominique Grimaud

    2001-01-01

    To evaluate the efficacy and safety of the multiple pe- ripheral nerve block technique at the humeral canal (humeral block) with the use of a neurostimulator, we prospectively studied 1417 patients undergoing upper limb surgery with a brachial plexus block at the hu- meral canal (1468 blocks). The success rate (defined as sensory block (in all nerve distributions) and\\/or the

  14. Natural Marine and Synthetic Xenobiotics Get on Nematode’s Nerves: Neuro-Stimulating and Neurotoxic Findings in Caenorhabditis elegans

    PubMed Central

    Lieke, Thora; Steinberg, Christian E. W.; Ju, Jingjuan; Saul, Nadine

    2015-01-01

    Marine algae release a plethora of organic halogenated compounds, many of them with unknown ecological impact if environmentally realistic concentrations are applied. One major compound is dibromoacetic acid (DBAA) which was tested for neurotoxicity in the invertebrate model organism Caenorhabditis elegans (C. elegans). This natural compound was compared with the widespread synthetic xenobiotic tetrabromobisphenol-A (TBBP-A) found in marine sediments and mussels. We found a neuro-stimulating effect for DBAA; this is contradictory to existing toxicological reports of mammals that applied comparatively high dosages. For TBBP-A, we found a hormetic concentration-effect relationship. As chemicals rarely occur isolated in the environment, a combination of both organobromines was also examined. Surprisingly, the presence of DBAA increased the toxicity of TBBP-A. Our results demonstrated that organohalogens have the potential to affect single organisms especially by altering the neurological processes, even with promoting effects on exposed organisms. PMID:25955755

  15. 5Fluorouracil: Forty-Plus and Still Ticking. A Review of its Preclinical and Clinical Development

    Microsoft Academic Search

    Jean L. Grem

    2000-01-01

    5-Fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) are pyrimidine analogs that have been partof the therapeutic armamentarium for a variety of solid tumorsfor over forty years. 5-FU has customarily required intravenousadministration due to poor and erratic oral bioavailability,while FdUrd has generally been employed for regionaladministration to the liver or the peritoneal cavity. A greatdeal of knowledge has been gained concerning the cellularpharmacology

  16. Extraoperative neurostimulation mapping: results from an international survey of epilepsy surgery programs

    PubMed Central

    Hamberger, Marla J.; Williams, Alicia C.; Schevon, Catherine A.

    2014-01-01

    Summary Purpose Extraoperative electrical stimulation mapping (ESM) to identify functional cortex is performed prior to neurosurgical resection at epilepsy surgery programs worldwide. However, the procedure remains unstandardized, with no established clinical guidelines. We sought to determine the current range in ESM practice parameters across established epilepsy surgery centers. Methods We developed and distributed a 31 question survey to 220 epilepsy centers worldwide regarding current practice parameters of ESM. Questions addressed preoperative assessment, technical stimulation parameters, language testing protocols, criteria for identification of positive or negative functional sites, management of mapping complications, and postoperative functional outcome. Key findings Survey responses were obtained from 56 centers. These revealed marked practice variability in virtually all aspects of the ESM procedure. Importantly, these aspects included critical procedure components such as electrical stimulation settings, the types of language functions tested, the operational definition of a language error, size of surgical resection margin, cortical locations mapped for language, testing in the presence of after discharges, and medical management of mapping complications. Forty-one percent of centers reported at least one persistent adverse language outcome despite preserving all eloquent sites defined by their stimulation mapping procedure. Significance The striking variations in practice across centers are likely to influence mapping results, which directly affect the boundaries of cortical resection and, consequently, might worsen either seizure or functional outcomes. Clearly, adverse functional outcomes occur despite mapping procedures that were perceived to be adequate. Investigation of critical technical and procedural aspects of stimulation mapping is warranted, with the ultimate goal of establishing empirically based practice guidelines to improve the safety and efficacy of ESM and resective epilepsy surgery. PMID:24816083

  17. Detail of center of swing span rotation. Forty (40) rods ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail of center of swing span rotation. Forty (40) rods radiate out from a center cap stand (like spokes on a bicycle) and hold 40 20-inch diameter wheels onto a rim bearing circular track on which they roll when swing span is opened and closed. - Bridgeport Swing Span Bridge, Spanning Tennessee River, Bridgeport, Jackson County, AL

  18. Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression.

    PubMed

    Bassi, Sabrina; Seney, Marianne L; Argibay, Pablo; Sibille, Etienne

    2015-04-01

    The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD. Hippocampal Cholinergic Neurostimulating Peptide (HCNP) regulates acetylcholine synthesis. The aim of the present work was to investigate expression levels of HCNP-precursor protein (HCNP-pp) mRNA and other cholinergic-related genes in the postmortem amygdala of MDD patients and matched controls (females: N = 16 pairs; males: N = 12 pairs), and in the mouse unpredictable chronic mild stress (UCMS) model that induced elevated anxiety-/depressive-like behaviors (females: N = 6 pairs; males: N = 6 pairs). Results indicate an up-regulation of HCNP-pp mRNA in the amygdala of women with MDD (p < 0.0001), but not males, and of UCMS-exposed mice (males and females; p = 0.037). HCNP-pp protein levels were investigated in the human female cohort, but no difference was found. There were no differences in gene expression of acetylcholinesterase (AChE), muscarinic (mAChRs) or nicotinic receptors (nAChRs) between MDD subjects and controls or UCMS and control mice, except for an up-regulation of AChE in UCMS-exposed mice (males and females; p = 0.044). Exploratory analyses revealed a baseline expression difference of cholinergic signaling-related genes between women and men (p < 0.0001). In conclusion, elevated amygdala HCNP-pp expression may contribute to mechanisms of MDD in women, potentially independently from regulating the cholinergic system. The differential expression of genes between women and men could also contribute to the increased vulnerability of females to develop MDD. PMID:25819500

  19. Walking and running in the desert ant Cataglyphis fortis.

    PubMed

    Wahl, Verena; Pfeffer, Sarah E; Wittlinger, Matthias

    2015-06-01

    Path integration, although inherently error-prone, is a common navigation strategy in animals, particularly where environmental orientation cues are rare. The desert ant Cataglyphis fortis is a prominent example, covering large distances on foraging excursions. The stride integrator is probably the major source of path integration errors. A detailed analysis of walking behaviour in Cataglyphis is thus of importance for assessing possible sources of errors and potential compensation strategies. Zollikofer (J Exp Biol 192:95-106, 1994a) demonstrated consistent use of the tripod gait in Cataglyphis, and suggested an unexpectedly constant stride length as a possible means of reducing navigation errors. Here, we extend these studies by more detailed analyses of walking behaviour across a large range of walking speeds. Stride length increases linearly and stride amplitude of the middle legs increases slightly linearly with walking speed. An initial decrease of swing phase duration is observed at lower velocities with increasing walking speed. Then it stays constant across the behaviourally relevant range of walking speeds. Walking speed is increased by shortening of the stance phase and of the stance phase overlap. At speeds larger than 370 mms(-1), the stride frequency levels off, the duty factor falls below 0.5, and Cataglyphis transitions to running with aerial phases. PMID:25829304

  20. Non-invasive interactive neurostimulation (InterX ™) reduces acute pain in patients following total knee replacement surgery: a randomised, controlled trial

    PubMed Central

    2011-01-01

    Background Adequate post-operative pain relief following total knee replacement (TKR) is very important to optimal post-operative recovery. Faster mobilisation and rehabilitation ultimately results in optimum recovery outcomes, but pain is often the limiting factor. This study evaluates the potential clinical benefit of the InterX neurostimulation device on pain reduction and rehabilitative outcome. Methods A clinical trial under the Hywel Dda Clinical Audit Committee to validate the clinical benefit of Non-invasive Interactive Neurostimulation (NIN) therapy using the InterX device was performed in patients undergoing TKR. 61 patients were randomised to treatment groups in blocks of two from the Theatre Operation List. The control group received the standard hospital course of pain medication and rehabilitation twice daily for 3 post-op days. The experimental group received 8 sessions of NIN therapy over 3 post-op days in addition to the standard course received by the Control group. Pain and range of motion were collected as the primary study measures. Results Sixty one subjects were enrolled and randomised, but 2 subjects (one/group) were excluded due to missing data at Baseline/Final; one subject in the InterX group was excluded due to pre-existing rheumatoid pain conditions confounding the analysis. The experimental group pre- to post-session Verbal Rating Scale for pain (VRS) showed that NIN therapy consistently reduced the pain scores by a mean of 2.3 points (SE 0.11). The NIN pre-treatment score at Final was used for the primary ANCOVA comparison, demonstrating a significantly greater cumulative treatment effect of a mean 2.2 (SE 0.49) points pain reduction (p = 0.002). Control subjects only experienced a mean 0.34 (SE 0.49) point decrease in pain. Ninety degrees ROM was required to discharge the patient and this was attained as an average despite the greater Baseline deficit in the InterX group. Eight control patients and three experimental patients did not achieve this ROM. Conclusions The results clearly demonstrated the clinical benefit of NIN therapy as a supplement to the standard rehabilitation protocol. The subjects receiving InterX fared significantly better clinically. Within a relatively short 3-day period of time, patients in the experimental group obtained the necessary ROM for discharge and did it experiencing lower levels of pain than those in the control group. PMID:21864362

  1. Switching from neurostimulant therapy to atomoxetine in children and adolescents with attention-deficit hyperactivity disorder : clinical approaches and review of current available evidence.

    PubMed

    Prasad, Suyash; Steer, Chris

    2008-01-01

    This review provides practical information on and clinical reasons for switching children and young people with attention-deficit hyperactivity disorder (ADHD) from neurostimulants to atomoxetine, detailing currently available evidence, and switching options. The issue is of particular relevance following recent guidance from the National Institute for Health and Clinical Excellence and European ADHD guidelines endorsing the use of atomoxetine, along with the stimulants methylphenidate and dexamphetamine, in the management of ADHD in children and adolescents in the UK. The selective norepinephrine (noradrenaline) reuptake inhibitor, atomoxetine, is a non-stimulant drug licensed for the treatment of ADHD in children and adolescents, and in adults who have shown a response in childhood. Following the once-daily morning dose, its therapeutic effects extend through the waking hours, into late evening, and in some patients, through to early the next morning. Atomoxetine may be considered for patients who are unresponsive or incompletely responsive to stimulant treatment, have co-morbid conditions (e.g. tics, anxiety, depression), and have sleep disturbances or eating problems, for patients in whom stimulants are poorly tolerated, and for situations where there is potential for drug abuse or diversion. Atomoxetine has been shown to be effective in relapse prevention and there is suggestion that atomoxetine may have a positive effect on global functioning; specifically health-related quality of life, self-esteem, and social and family functioning. According to one study, approximately 50% of non-responders to methylphenidate will respond to atomoxetine therapy and approximately 75% of responders to methylphenidate will also respond to atomoxetine. Atomoxetine may be initiated by a schedule of dose increases and cross-tapering with methylphenidate. A slow titration schedule with divided doses minimizes the impact of adverse events within the first several weeks of treatment. Atomoxetine may be co-administered with methylphenidate during the switching period without undue concern for adverse events, such as cardiovascular effects (although monitoring of blood pressure and heart rate is necessary). Atomoxetine may be discontinued abruptly and patients may miss the occasional dose without rebound effects or discontinuation syndrome. A trial period of at least 6-8 weeks, perhaps longer, is recommended before evaluation of the overall tolerability and efficacy of atomoxetine. We conclude that patients with ADHD can be switched from neurostimulants, specifically methylphenidate, to atomoxetine, and may benefit from symptom improvement. PMID:18162007

  2. Long-Term Precision of DXA Scanning Assessed over Seven Years in Forty Postmenopausal Women

    Microsoft Academic Search

    R. Patel; G. M. Blake; J. Rymer; I. Fogelman

    2000-01-01

    :   The reproducibility of dual-energy X-ray absorptiometry (DXA) measurements of bone mineral density (BMD) is an important\\u000a factor for longitudinal studies. We assessed the long-term precision of posteroanterior lumbar spine, femoral neck and total\\u000a hip BMD in 40 postmenopausal women who formed the control arm of a clinical trial of tibolone. BMD was measured at 0, 6 and\\u000a 12 months

  3. Nocturnal re-experiencing more than forty years after war trauma.

    PubMed

    Schreuder, B J; Kleijn, W C; Rooijmans, H G

    2000-07-01

    The aim of this study was the examination of Posttraumatic Nightmares (PTNM) and Posttraumatic Anxiety Dreams (PTAD) in Dutch combat veterans and World War II victims. Participants (outpatients; n = 223) were administered a standardized psychiatric interview, the Impact of Event Scale, the SCL-90, the Clinician Administered PTSD Scale, and an interview on posttraumatic nocturnal re-experiencing. Prevalence of PTNM was 56%. Patients with PTNM, even those who were not diagnosed with PTSD, had significantly more psychiatric complaints than patients with no PTNM. Analysis of PTNM demonstrated that they were often experienced as exact replications of the original traumatic events. Replicative PTNM often implicated dream recurrence. Traumatic experiences before the age of 5 resulted in nonreplicative PTNM only. Unlike nonreplicative PTNM, replicative PTNM seemed to be correlated with several intrusion subscales. PMID:10948485

  4. Forty-eight years of landscape change on two contiguous Ohio landscapes

    Microsoft Academic Search

    John W. Simpson; Ralph E. J. Boerner; Michael N. DeMers; Leslie A. Berns; Francisco J. Artigas; Alejandra Silva

    1994-01-01

    This study analyzes the current and historic structure of two contiguous, rural landscapes covering approximately 242 km2 in central Ohio, USA: a till plain landscape with relatively homogeneous topography and soils, and a moraine landscape with greater geomorphological diversity and heterogeneity. These landscapes were chosen because they were both heavily dominated by agriculture during 1900–1940 and were both initially surveyed

  5. Forty Years in the Union: Incubating, Supporting, and Catalyzing Socially Just Educational Change

    ERIC Educational Resources Information Center

    Rottmann, Cindy

    2012-01-01

    North American teacher unions' positive contributions to educational change have historically flown under the radar of educational policy makers, a situation that has been reified by recent attacks on public sector unions. In this article, I draw on social movement theory and an institutional case study of a self described social justice union to…

  6. Forty Years on: The Issue of Breadth in the Post-16 Curriculum.

    ERIC Educational Resources Information Center

    Pound, Tim

    1998-01-01

    Discusses the reform efforts in England for restructuring the post-16 curriculum. Relates the history of the Crowther Committee's agenda for specialization within the curriculum and addresses the two proposals by A. D. C. Peterson and B. W. M Young who each provided alternatives for broadening the curriculum in order to combat the proposal for…

  7. INVITED EDITORIAL: A meander through forty years of The Society for Radiological Protection

    Microsoft Academic Search

    John Jackson

    2003-01-01

    On the 8th May 1963, 64 men and two women gathered in an austere lecture theatre at Imperial College, University of London. They came from all sections of the nuclear industry, both civil and military, and from radiology, radiological protection and academic backgrounds. And they came with a common purpose, to witness the foundation of the `The Society for Radiological

  8. Forty years of landscape change in Attwater's Prairie Chicken habitat within the Coastal Prairie of Texas 

    E-print Network

    McKinney, Lloyd B.

    1996-01-01

    spatial statistics for Kirtland's warbler (Dendroica kirtlandii) habitat in Michigan. Similar statistics were calculated for northern spotted owl (Strix occidentalis caurina) habitat in Oregon with important ecological and management implications...

  9. Forty Years of Diffusion of Innovations: Utility and Value in Public Health

    Microsoft Academic Search

    MUHIUDDIN HAIDER; GARY L. KREPS

    2004-01-01

    This special issues is created to mark the 40 anniversary of Everett Rogers’ Diffusion of Innovations (DOI) model. Diffusion is the process through which an innovation, defined as an idea perceived as new, spreads via certain communication channels over time among the members of a particular social system. A great deal of research in a variety of academic disciplines (about

  10. Forty years of litigation involving medical students and their education: II. Issues of finance.

    PubMed

    Helms, L B; Helms, C M

    1991-02-01

    An analysis of reported state and federal adjudication from 1950 through 1989 was undertaken to identify trends in litigation involving medical students and undergraduate medical education. Of the 110 cited judicial decisions during that time, 59 (54%) involved disputes over financing medical education; 43 (73%) were litigated since 1985. This dramatic increase arises primarily from challenges to National Health Service Corps obligations and from attempts to discharge or reorganize debt under the Bankruptcy Code. Medical school graduates enjoyed very little success in these cases. Analysis of court decisions points to a need for informed counseling for medical students, particularly as to the consequences of timing in default on service obligations and of incurring loans under the Health Education Assistance Loan (HEAL) program as opposed to other loan sources. The growing educational debt of today's medical students foreshadows continued litigation in this area. PMID:1993104

  11. Forty-five years of observed soil moisture in the Ukraine: No summer desiccation (yet)

    Microsoft Academic Search

    Alan Robock; Mingquan Mu; Konstantin Vinnikov; Iryna V. Trofimova; Tatyjana I. Adamenko

    2005-01-01

    We present the longest data set of observed soil moisture available in the world, 45 yr of gravimetrically-observed plant available soil moisture for the top 1 m of soil, observed every 10 days for April-October for 141 stations from fields with either winter or spring cereals from the Ukraine for 1958-2002. We averaged the summer observations over the entire region

  12. Forty-Two Ethiopian Boys: Observations of Their First Year in Israel.

    ERIC Educational Resources Information Center

    Zima, Suellen

    1987-01-01

    Provides observations by a social worker functioning as a housemother to Ethiopian Jewish refugee adolescent boys recently arrived in Israel. Discusses boys' technologicial and cultural adjustment, health and mental health problems, and racial problems. (ABL)

  13. The Changing Frontiers of Comparative Education: A Forty-Year Retrospective on "European Education"

    ERIC Educational Resources Information Center

    Silova, Iveta

    2009-01-01

    "European Education" (originally known as "Western European Education") may no longer be directly associated with the field of comparative and international education, yet its establishment in 1969 was an attempt to make a direct contribution to the academic debates about the future of comparative education. The journal emerged at a time when…

  14. Reflections on Forty Years of Geographical Information in Scotland: Standardisation, Integration and Representation

    Microsoft Academic Search

    Bruce M. Gittings

    2009-01-01

    This paper examines some of the key events which have influenced the development of Geographical Information Systems in Scotland, together with the contribution which Scotland has made to the international scene. It reviews local developments and applications, the people who brought these about and links them to key technological milestones on the international stage. The paper also examines issues of

  15. Enduring Documents and Public Doctrines: Martin Luther King's "Letter from Birmingham Jail" after Forty Years

    ERIC Educational Resources Information Center

    Aeschliman, M. D.

    2005-01-01

    In the century just past, the immense ethical and political destructiveness of intellectuals was so frequent and protean in form that intellectual historians have a story as complex as it is tragic to tell, and one that many of them do not relish, perhaps out of occupational solidarity or shame. The "treason of the intellectuals," to use Julien…

  16. A Forty Year Perspective on Effects of Child Abuse and Neglect.

    ERIC Educational Resources Information Center

    McCord, Joan

    1983-01-01

    Between 1975 and 1979, 98 percent of men identified as young children were retraced. Records for juvenile delinquency showed higher rates among abused, neglected, and rejected boys than those raised by loving parents. Alcoholism, divorce, and occupational success rates were similar among the four groups. Maternal self-confidence and education…

  17. Forty Years of Struggle and Still No Right to Inuit Education in Nunavut

    ERIC Educational Resources Information Center

    Rasmussen, Derek

    2011-01-01

    In this article issues related to policy and education in the Canadian Arctic are critically put to question. The focus is on the struggle for Inuit education, language issues, and supporting minority rights, with pragmatic solutions proposed to the problems confronting Nunavut.

  18. Forty years on: Uta Frith's contribution to research on autism and dyslexia, 1966–2006

    PubMed Central

    Bishop, Dorothy V. M.

    2008-01-01

    Uta Frith has made a major contribution to our understanding of developmental disorders, especially autism and dyslexia. She has studied the cognitive and neurobiological bases of both disorders and demonstrated distinctive impairments in social cognition and central coherence in autism, and in phonological processing in dyslexia. In this enterprise she has encouraged psychologists to work in a theoretical framework that distinguishes between observed behaviour and the underlying cognitive and neurobiological processes that mediate that behaviour. PMID:18038335

  19. A study of the factors influencing forty years' operations on a large Texas cattle ranch

    E-print Network

    Matthews, Joseph Luther

    1947-01-01

    @ %ushers of Boreas and gules Cattle . ales by gears V, Changes in Organisation and ganagesent?19+ to 19' ~ ~ i ~ Lano. available for Grasing Livestock storing "aeilit i~s Changes in Ao-es Cresed Per, '. ow Coaperison of, e3, hts of GattIe ooid...

  20. Forty years of research on xeroderma pigmentosum at the US National Institutes of Health.

    PubMed

    Kraemer, Kenneth H; DiGiovanna, John J

    2015-01-01

    In 1968, Dr. James Cleaver reported defective DNA repair in cultured cells from patients with xeroderma pigmentosum. This link between clinical disease and molecular pathophysiology has sparked interest in understanding not only the clinical characteristics of sun sensitivity, damage and cancer that occurred in XP patients but also the mechanisms underlying the damage and repair. While affected patients are rare, their exaggerated UV damage provides a window into the workings of DNA repair. These studies have clarified the importance of a functioning DNA repair system to the maintenance of skin and neurologic health in the general population. Understanding the role of damage in causing cancer, neurologic degeneration, hearing loss and internal cancers provides an opportunity for prevention and treatment. Characterizing complementation groups pointed to the importance of different underlying genes. Studying differences in cancer age of onset and underlying molecular signatures in cancers occurring either in XP patients or the general population has led to insights into differences in carcinogenic mechanisms. The accelerated development of cancers in XP has been used as a model to discover new cancer chemopreventive agents. An astute insight can be a "tipping point" triggering decades of productive inquiry. PMID:25220021

  1. Blood Groups and Milk and Type Traits in Dairy Cattle: After Forty Years of Research

    Microsoft Academic Search

    J. L. Rocha; J. O. Sanders; D. M. Cherbonnier; T. J. Lawlor; J. F. Taylor

    1998-01-01

    This study addresses the utility of 11 blood groups as selection aids in Holstein breeding schemes and considers issues inherent to the approach of resolving quantitative variation into components that are due to quantitative trait loci. The data consisted of predicted transmitting abilities of 22,614 bulls, first lactation information on 1,924,171 cows, and type scores on 447,800 cows. Linear models

  2. Forty Years of Erratic Insecticide Resistance Evolution in the Mosquito Culex pipiens

    Microsoft Academic Search

    Pierrick Labbé; Claire Berticat; Arnaud Berthomieu; Sandra Unal; Clothilde Bernard; Mylène Weill; Thomas Lenormand

    2007-01-01

    One view of adaptation is that it proceeds by the slow and steady accumulation of beneficial mutations with small effects. It is difficult to test this model, since in most cases the genetic basis of adaptation can only be studied a posteriori with traits that have evolved for a long period of time through an unknown sequence of steps. In

  3. Intergenerational Transfer of Smoking Across Three Generations and Forty-five Years

    PubMed Central

    2014-01-01

    Objectives: Although many have examined the linkages between smoking behaviors across 2 generations, few have examined these linkages among 3 generations. Methods: U.S. population representative data for 3 generations are drawn from the Panel Study of Income Dynamics (PSID) in order to examine whether smoking behaviors are passed down from generation to generation and the magnitude of the influence of smoking behaviors across generations (N = 830). Results: Results indicate direct linkages between both grandparent (G1) and parent (G2) smoking (OR = 4.53; 95% CI = 2.57–7.97) and parent (G2) and young adult offspring (G3) smoking (OR = 2.91; 95% CI = 1.60–5.31). Although the direct link between grandparent (G1) and grandchildren (G3) was not significant (OR = 2.25; 95% CI = 0.96–5.23, p < .10), mediation analyses reveal that the link between G3 and G1 smoking is significantly mediated by G2 smoking. Conclusions: Regardless of generation, parent smoking behavior has a direct influence on offspring smoking behavior. The link between grandparent (G1) and grandchild (G3) smoking is mediated by parent (G2) smoking, suggesting that smoking behavior is passed from one generation to the next generation and in turn to the next generation. PMID:23943844

  4. [Forty years of progress in the therapeutic management of lung cancer].

    PubMed

    Van Houtte, P; Roelandts, M; Mornex, F

    2014-10-01

    This article reviews and describes the progress made in the therapeutic management of patients suffering from a lung cancer, outlining the major improvements made and suggesting some perspectives for the future. PMID:25195118

  5. Forty-five years after Broadbent (1958): still no identification without attention

    NASA Technical Reports Server (NTRS)

    Lachter, Joel; Forster, Kenneth I.; Ruthruff, Eric

    2004-01-01

    According to D. E. Broadbent's (1958) selective filter theory, people do not process unattended stimuli beyond the analysis of basic physical properties. This theory was later rejected on the basis of numerous findings that people identify irrelevant (and supposedly unattended) stimuli. A careful review of this evidence, however, reveals strong reasons to doubt that these irrelevant stimuli were in fact unattended. This review exposed a clear need for new experiments with tight control over the locus of attention. The authors present 5 such experiments using a priming paradigm. When steps were taken to ensure that irrelevant stimuli were not attended, these stimuli produced no priming effects. Hence, the authors found no evidence that unattended stimuli can be identified. The results support a modern version of Broadbent's selective theory, updated to reflect recent research advances. 2004 APA.

  6. 77 FR 54930 - Carlyle Plastics and Resins, Formerly Known as Fortis Plastics, A Subsidiary of Plastics...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ...TA-W-81,655] Carlyle Plastics and Resins, Formerly Known as Fortis Plastics...Plastics is now called Carlyle Plastics and Resins. In addition, new information shows...All workers of Carlyle Plastics and Resins, formerly known as Fortis...

  7. Effect of Dietary Intake on Urinary Oxalate Excretion in Calcium Oxalate Stone Formers in Their Forties

    Microsoft Academic Search

    Y. Naya; H. Ito; M. Masai; K. Yamaguchi

    2000-01-01

    Purpose: To examine the influence of dietary intake on urinary oxalate excretion in calcium oxalate stone formers in their forties.Patients and Methods: Dietary intake was recorded by using the dietary–record method in 58 idiopathic stone formers in their forties. The patients collected their urine for 24 h at home and their urinary oxalate excretion was measured. The relationship between the

  8. The Rearranged Workweek of Four Days, Forty Hours with a Treatment of Military Applications.

    ERIC Educational Resources Information Center

    Foster, William J.

    The primary purpose of the study was to develop a military reference on the rearranged workweek, especially the four-day, forty-hour arrangement. In the research an extensive review of pertinent literature was accomplished to provide the necessary background to properly evaluate the military four-day, forty-hour workweek experience at McGuire Air…

  9. Forty-five Returnees to Regular High Schools.

    ERIC Educational Resources Information Center

    Joseph, M. P.; Almen, R. E.

    The Work Opportunity Center (WOC) is geared to provide occupational skills training, related instruction, counseling, and personal services to youth 16 to 21 years of age. Many of these boys experienced learning difficulties in the traditional school setting and withdrew from school. In addition to providing work orientation, the WOC encourages…

  10. Habitat evaluation for outbreak of Yangtze voles (Microtus fortis) and management implications.

    PubMed

    Xu, Zhenggang; Zhao, Yunlin; Li, Bo; Zhang, Meiwen; Shen, Guo; Wang, Yong

    2015-05-01

    Rodent pests severely damage agricultural crops. Outbreak risk models of rodent pests often do not include sufficient information regarding geographic variation. Habitat plays an important role in rodent-pest outbreak risk, and more information about the relationship between habitat and crop protection is urgently needed. The goal of the present study was to provide an outbreak risk map for the Dongting Lake region and to understand the relationship between rodent-pest outbreak variation and habitat distribution. The main rodent pests in the Dongting Lake region are Yangtze voles (Microtus fortis). These pests cause massive damage in outbreak years, most notably in 2007. Habitat evaluation and ecological details were obtained by analyzing the correlation between habitat suitability and outbreak risk, as indicated by population density and historical events. For the source-sink population, 96.18% of Yangtze vole disaster regions were covered by a 10-km buffer zone of suitable habitat in 2007. Historical outbreak frequency and peak population density were significantly correlated with the proportion of land covered by suitable habitat (r = 0.68, P = 0.04 and r = 0.76, P = 0.03, respectively). The Yangtze vole population tends to migrate approximately 10 km in outbreak years. Here, we propose a practical method for habitat evaluation that can be used to create integrated pest management plans for rodent pests when combined with basic information on the biology, ecology and behavior of the target species. PMID:25316099

  11. Proceedings of the Forty-Fourth Annual Meeting of the American Psychological Association, Incorporated, Hanover, New Hampshire, September 2, 3, 4, 5, 1936

    Microsoft Academic Search

    1936-01-01

    Reports the proceedings of the Forty-Fourth Annual Meeting of the American Psychological Association held in September 1936. This article contains committee and division reports, the budget for fiscal year December 16, 1936 to December 15, 1937, and abstracts of papers.

  12. Indoor air quality study of forty east Tennessee homes

    SciTech Connect

    Hawthorne, A.R.; Gammage, R.B.; Dudney, C.S.; Hingerty, B.E.; Schuresko, D.D.; Parzyck, D.C.; Womack, D.R.; Morris, S.A.; Westley, R.R.; White, D.A.

    1984-12-01

    Over a one-year period, measurements of indoor air pollutants (CO/sub x/, NO/sub x/, formaldehyde, volatile organics, particulates, and radon) were made in 40 homes in East Tennessee. The houses were of various ages with different types of insulation and heating. Over one-half of the houses exceeded the ASHRAE indoor ceiling guideline of 0.1 ppM for formaldehyde on at least one occasion. Over the duration of the study, older houses averaged 0.04 ppM of formaldehyde while houses less than 5 years old averaged 0.08 ppM (P < 0.01). The highest concentration of formaldehyde measured was 0.4 ppM in a new home. Diurnal and seasonal fluctuations in levels of formaldehyde in some homes were as much as twofold and tenfold, respectively. The highest levels of formaldehyde were usually recorded during summer months. The concentration in indoor air of various organics was at least tenfold higher than in outdoor air. Carbon monoxide and nitrgen oxides were usually <2 and <0.02 ppM, respectively, except when gas stoves or kerosene space heaters were operating, or when a car was running in the garage. In 30% of the houses, the annual indoor guideline for radon, 4 pCi/L, was exceeded. The mean radon level in houses built on the ridgelines was 4.4 pCi/L, while houses located in the valleys had a mean level of 1.7 pCi/L (P < 0.01). The factor having the most impact on infiltration was operation of the central duct fan of the heating, ventilation, and air conditioning system. The mean rate of air exchange increased from 0.39 to 0.74 h/sup -1/ when the duct fan was operated (measurements prior to December 1982). This report presents the study design and implementation, describes the monitoring protocols, and provides a complete set of the data collected during the project. 25 references, 29 figures, 42 tables.

  13. Effects of Microtus fortis lymphocytes on Schistosoma japonicum in a bone marrow transplantation model.

    PubMed

    Hu, Yuan; Xu, Yuxin; Lu, Weiyuan; Quan, Hong; Shen, Yujuan; Yuan, Zhongying; Zhang, Jing; Zang, Wei; He, Yongkang; Cao, Jianping

    2014-07-01

    Microtus fortis is a non-permissive host for Schistosoma japonicum. While M. fortis lymphocytes are known to provide natural resistance against S. japonicum, the specific mechanism remains unclear. A bone marrow transplantation (BMT) model was established using immunodeficient mice, either nude (experiment 1) or V(D)J recombination activation gene deficient mice (RAG-1(-/-)) (experiment 2) as recipients and M. fortis or C57BL/6 mice as donors. The growth and development of S. japonicum were evaluated in each group to assess the role of M. fortis lymphocytes in the response to infection. Lymphocyte ratios and S. japonicum-specific antibody production in transplanted groups increased significantly compared to those in non-transplanted group. Spleen indices and density of splenic lymphocytes in transplanted RAG-1(-/-) mice were higher than those in non-transplanted RAG-1(-/-) mice. No difference in the worm burden was observed among group A (transplants derived from M. fortis), B (transplants derived from C57BL/6 mouse) and C (non-transplanted mice), although worms in group A were shorter than those in other groups, except non-transplanted RAG-1(-/-) mice. Reproductive systems of worms in mice (nude or RAG-1(-/-)) transplanted from M. fortis were not as mature as those in mice (nude or RAG-1(-/-)) transplanted from C57BL/6 mouse and non-transplanted nude mice, but they were more mature than worms in non-transplanted RAG-1(-/-) mice. Therefore, the transplantation model using nude and RAG-1(-/-) mice was successfully established. The M. fortis lymphocytes did not appear to affect the S. japonicum worm burden, but they led to schistosome shortening and a significant reduction in parasite spawning. Thus, M. fortis cellular and humoral immunity provides a defense against schistosomes by negatively impacting the parasite growth and reproductive development. PMID:24746640

  14. 32 CFR 169a.13 - CAs involving forty-five or fewer DoD civilian employees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...false CAs involving forty-five or fewer DoD civilian employees...13 CAs involving forty-five or fewer DoD civilian employees...involving more than forty-five employees be modified, reorganized...cost-effective organization analysis certification is required...

  15. 32 CFR 169a.13 - CAs involving forty-five or fewer DoD civilian employees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...false CAs involving forty-five or fewer DoD civilian employees...13 CAs involving forty-five or fewer DoD civilian employees...involving more than forty-five employees be modified, reorganized...cost-effective organization analysis certification is required...

  16. 32 CFR 169a.13 - CAs involving forty-five or fewer DoD civilian employees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...false CAs involving forty-five or fewer DoD civilian employees...13 CAs involving forty-five or fewer DoD civilian employees...involving more than forty-five employees be modified, reorganized...cost-effective organization analysis certification is required...

  17. 32 CFR 169a.13 - CAs involving forty-five or fewer DoD civilian employees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...false CAs involving forty-five or fewer DoD civilian employees...13 CAs involving forty-five or fewer DoD civilian employees...involving more than forty-five employees be modified, reorganized...cost-effective organization analysis certification is required...

  18. 32 CFR 169a.13 - CAs involving forty-five or fewer DoD civilian employees.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...false CAs involving forty-five or fewer DoD civilian employees...13 CAs involving forty-five or fewer DoD civilian employees...involving more than forty-five employees be modified, reorganized...cost-effective organization analysis certification is required...

  19. On-demand pulsatile intracerebral delivery of carisbamate with closed-loop direct neurostimulation therapy in an electrically induced self-sustained focal-onset epilepsy rat model.

    PubMed

    Mangubat, Erwin Z; Kellogg, Robert G; Harris, Timothy J; Rossi, Marvin A

    2015-06-01

    OBJECT The authors evaluated the preclinical feasibility of acutely stabilizing an active bihemispheric limbic epileptic circuit using closed-loop direct neurostimulation therapy in tandem with "on-demand'" convection-enhanced intracerebral delivery of the antiepileptic drug (AED) carisbamate. A rat model of electrically induced self-sustained focal-onset epilepsy was employed. METHODS A 16-contact depth-recording microelectrode was implanted bilaterally in the dentate gyrus (DG) of the hippocampus of Fischer 344 rats. The right microelectrode array included an integrated microcatheter for drug delivery at the distal tip. Bihemispheric spontaneous self-sustained limbic status epilepticus (SSLSE) was induced in freely moving rats using a 90-minute stimulation paradigm delivered to the right medial perforant white matter pathway. Immediately following SSLSE induction, closed-loop right PP stimulation therapy concurrent with on-demand nanoboluses of the AED [(14)C]-carisbamate (n = 4), or on-demand [(14)C]-carisbamate alone (n = 4), was introduced for a mean of 10 hours. In addition, 2 reference groups received either closed-loop stimulation therapy alone (n = 4) or stimulation therapy with saline vehicle only (n = 4). All animals were sacrificed after completing the specified therapy regimen. In situ [(14)C]-autoradiography was used to determine AED distribution. RESULTS Closed-loop direct stimulation therapy delivered unilaterally in the right PP aborted ictal runs detected in either ipsi- or contralateral hippocampi. Freely moving rats receiving closed-loop direct stimulation therapy with ondemand intracerebral carisbamate delivery experienced a significant reduction in seizure frequency (p < 0.001) and minimized seizure frequency variability during the final 50% of the therapy/recording session compared with closed-loop stimulation therapy alone. CONCLUSIONS Unilateral closed-loop direct stimulation therapy delivered to afferent hippocampal white matter pathways concurrent with on-demand ipsilateral intracerebral delivery of nano-bolused carisbamate can rapidly decrease the frequency of electrographic seizures in an active bihemispheric epileptic network. Additionally, direct pulsatile delivery of carisbamate can stabilize seizure frequency variability compared with direct stimulation therapy alone. PMID:25723302

  20. Apoptosis Governs the Elimination of Schistosoma japonicum from the Non-Permissive Host Microtus fortis

    PubMed Central

    Peng, Jinbiao; Gobert, Geoffrey N.; Hong, Yang; Jiang, Weibin; Han, Hongxiao; McManus, Donald P.; Wang, Xinzhi; Liu, Jinming; Fu, Zhiqiang; Shi, Yaojun; Lin, Jiaojiao

    2011-01-01

    The reed vole, Microtus fortis, is the only known mammalian host in which schistosomes of Schistosoma japonicum are unable to mature and cause significant pathogenesis. However, little is known about how Schistosoma japonicum maturation (and, therefore, the development of schistosomiasis) is prevented in M. fortis. In the present study, the ultrastructure of 10 days post infection schistosomula from BALB/c mice and M. fortis were first compared using scanning electron microscopy and transmission electron microscopy. Electron microscopic investigations showed growth retardation and ultrastructural differences in the tegument and sub-tegumental tissues as well as in the parenchymal cells of schistosomula from M. fortis compared with those in BALB/c mice. Then, microarray analysis revealed significant differential expression between the schistosomula from the two rodents, with 3,293 down-regulated (by ?2-fold) and 71 up-regulated (?2 fold) genes in schistosomula from the former. The up-regulated genes included a proliferation-related gene encoding granulin (Grn) and tropomyosin. Genes that were down-regulated in schistosomula from M. fortis included apoptosis-inhibited genes encoding a baculoviral IAP repeat-containing protein (SjIAP) and cytokine-induced apoptosis inhibitor (SjCIAP), genes encoding molecules involved in insulin metabolism, long-chain fatty acid metabolism, signal transduction, the transforming growth factor (TGF) pathway, the Wnt pathway and in development. TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) and PI/Annexin V-FITC assays, caspase 3/7 activity analysis, and flow cytometry revealed that the percentages of early apoptotic and late apoptotic and/or necrotic cells, as well as the level of caspase activity, in schistosomula from M. fortis were all significantly higher than in those from BALB/c mice. PMID:21731652

  1. Draft Genome Sequence of Vibrio fortis Dalian14 Isolated from Diseased Sea Urchin (Strongylocentrotus intermedius)

    PubMed Central

    Ding, Jun; Dou, Yan; Wang, Yinan

    2014-01-01

    Here, we report the draft genome sequence of Vibrio fortis Dalian14 isolated from diseased sea urchin (Strongylocentrotus intermedius) during disease outbreaks in North China. The availability of this genome sequence will facilitate the study of the mechanisms of pathogenicity and evolution of Vibrio species. PMID:24994792

  2. Ecoimmunity in Darwin's Finches: Invasive Parasites Trigger Acquired Immunity in the Medium Ground Finch (Geospiza fortis)

    Microsoft Academic Search

    Sarah K. Huber; Jeb P. Owen; Jennifer A. H. Koop; Marisa O. King; Peter R. Grant; B. Rosemary Grant; Dale H. Clayton

    2010-01-01

    Background: Invasive parasites are a major threat to island populations of animals. Darwin's finches of the Galapagos Islands are under attack by introduced pox virus (Poxvirus avium) and nest flies (Philornis downsi). We developed assays for parasite-specific antibody responses in Darwin's finches (Geospiza fortis), to test for relationships between adaptive immune responses to novel parasites and spatial-temporal variation in the

  3. FORTY "STRANGE" COMPUTER-DISCOVERED [and COMPUTER-PROVED (of course!)

    E-print Network

    Zeilberger, Doron

    of this article is in its form. A computer discoveri* *ng ab initio, humanly- nice results, worthy of the name FORTY "STRANGE" COMPUTER-DISCOVERED [and COMPUTER* * and annotated Zeilberger algorithm, implemented in the Maple package twoFone. Foreword (by Human Doron

  4. CHLORINATION, WATER HARDNESS, AND SERUM CHOLESTEROL IN FORTY-SIX WISCONSIN COMMUNITIES

    EPA Science Inventory

    The Wisconsin Heart Health Research Program measured serum lipids and other clinical parameters among residents of forty-six neighboring small communities in central Wisconsin. he purpose of the study was to determine whether distribution of serum lipids, blood pressure or thyroi...

  5. Neurostimulation using subnanosecond electric pulses

    NASA Astrophysics Data System (ADS)

    Xiao, Shu; Pakhomov, Andrei; Guo, Fei; Polisetty, Swetha; Schoenbach, Karl H.

    2013-02-01

    We have for the first time recorded action potentials in rat hippocampus neurons when they were stimulated by subnanosecond electric pulses. The preliminary results show that applying a series of pulses allowed the accumulation of depolarization before activating the voltage gated channels. The depolarization only occurred when the electric pulses were applied. It is unclear whether the depolarization is caused by the charge accumulation across the membrane or the cation influx due to the membrane permeabilization. We have also conducted an electromagnetic simulation of delivering subnanosecond pulses to tissues using an impulse radiating antenna. The results show that the pulses can be confined in the deep region in the brain but the amplitude is reduced significantly due to the attenuation of the tissues. A partially lossy dielectric lens may be used to reverse the decreasing trend of the electric field.

  6. Neutron capture therapy: Years of experimentation---Years of reflection

    SciTech Connect

    Farr, L.E.

    1991-12-16

    This report describes early research on neutron capture therapy over a number of years, beginning in 1950, speaking briefly of patient treatments but dwelling mostly on interpretations of our animal experiments. This work carried out over eighteen years, beginning over forty years ago. Yet, it is only fitting to start by relating how neutron capture therapy became part of Brookhaven's Medical Research Center program.

  7. First report of genotyping of Toxoplasma gondii in free-living Microtus fortis in northeastern China.

    PubMed

    Zhang, Xiao-Xuan; Huang, Si-Yang; Zhang, Ying-Guang; Zhang, Yuan; Zhu, Xing-Quan; Liu, Quan

    2014-10-01

    Toxoplasma gondii is an intracellular protozoan parasite which imperils the health of almost all warm-blooded animals, including humans. The objective of this study was to determine genetic characterization of T. gondii in free-living Microtus fortis (reed vole) in Jilin province, northeastern China. A total of 104 DNA samples, 74 from Gongzhuling and 30 from Baicheng, were extracted from lung tissues of M. fortis , and 56 (53.8%) of them were positive for T. gondii by semi-nested polymerase chain reaction of the B1 gene. These positive DNA samples were typed at 10 genetic markers including SAG1, 5'- and 3'-SAG2, alternative SAG2, BUTB, GRA6, L358, PK1, c22-8, c29-2, and Apico. Four samples were successfully genotyped at all genetic loci and grouped to 2 distinct genotypes; 2 samples belonged to ToxoDB Genotype no. 10 (Type I) and the other 2 presented ToxoDB Genotype no. 9 ( http://toxodb.org/toxo/ ); 4 samples were genotyped at 8 genetic loci, in which 2 samples belonged to ToxoDB Genotype no. 10 and 2 presented ToxoDB Genotype no. 9. To our knowledge, this is the first report of genetic typing of T. gondii from free-living M. fortis in northeast China. The results suggest that the Type I and ToxoDB Genotype no. 9 could be a potential risk factor for transmission through the reed vole in this region. PMID:24684624

  8. Survey of Yucca Mountain, Forty-Mile Canyon, and Jackass Flats in Nye County, Nevada for desert tortoise, Gopherus agassizii

    SciTech Connect

    Medica, P.A.; O`Farrell, T.P.; Collins, E.

    1981-10-01

    The objective of this brief survey was to determine if G. agassizii is present west of Forty-Mile Canyon in the Yucca Mountain.. area, or along the major access roads which lead through Jackass Flats to Forty-Mile Canyon and Yucca Mountain

  9. Forty-eight-hour ph monitoring increases sensitivity in detecting abnormal esophageal acid exposure

    Microsoft Academic Search

    Daniel Tseng; Adnan Z. Rizvi; M. Brian Fennerty; Blair A. Jobe; Brian S. Diggs; Brett C. Sheppard; Steven C. Gross; Lee L. Swanstrom; Nicole B. White; Ralph W. Aye; John G. Hunter

    2005-01-01

    Ambulatory 24-hour esophageal pH measurement is the standard for detecting abnormal esophageal acid exposure (AEAE), but it\\u000a has a false negative rate of 15% to 30%. Wireless 48-hour pH monitoring (Bravo; Medtronic, Shoreview, MN) may allow more accurate\\u000a detection of AEAE versus 24-hour pH monitoring. Forty-eight-hour wireless data were reviewed from 209 patients at three different\\u000a tertiary care referral centers

  10. Reform Under Attack--Forty Years of Working on Better Mathematics Education Thrown on the Scrapheap? No Way!

    ERIC Educational Resources Information Center

    van den Heuvel-Panhuizen, Marja

    2010-01-01

    This paper addresses the reform of mathematics education in the Netherlands and the attacks that presently take place against this reform. The attacks concentrate on primary education and criticize in particular the program for teaching calculation skills with long division as a case in point. The paper gives an overview of what Realistic…

  11. La Matematica e la sua didattica, quarant'anni di impegno Mathematics and its didactics, forty years of commitment

    E-print Network

    Spagnolo, Filippo

    Benini, Alberto Bertoni, Luis Ángel Bohórquez Arenas (Colombia), Giorgio Bolondi, Umberto Bottazzini, Guy), Colette Laborde (Francia), Olga Lucía León Corredor (Colombia), Salvador Llinares (Spagna), Daniela Peres, Michele Pertichino, Monika Porkertova (Slovacchia), Demetris Portides (Cipro), Luis Radford

  12. A Forty-Year Retrospective 1950-1990: The Metropolitan Toronto and Region Conservation Authority's Conservation Education Programmes.

    ERIC Educational Resources Information Center

    Carr, Allen Terry

    1996-01-01

    Recounts the growth of Conservation Authorities in Ontario from the first partnerships between schools and conservation in the 1950s, to the opening of a pioneer village, flood control dam, nature trails, and residential conservation education centers through the 1960s and 1970s. Increased public environmental concern sparked more growth in the…

  13. Forty-two years of succession following strip clearcutting in a northern hardwoods forest in northwestern Massachusetts

    Microsoft Academic Search

    Taber D. Allison; Henry W. Art; Frank E. Cunningham; Rebecca Teed

    2003-01-01

    We investigated the effects of strip width, slope position, and soil scarification in a split–split plot design on the regeneration of northern hardwoods in northwestern Massachusetts. Whole plots of 20 and 40m in width were cut in 1954 in a second growth forest dominated by Betula papyrifera. Slope position and soil scarification were the split and split–split plot treatments, respectively.

  14. Effect of population density on reproduction in Microtus fortis under laboratory conditions.

    PubMed

    Han, Qunhua; Zhang, Meiwen; Guo, Cong; Shen, Guo; Wang, Yong; Li, Bo; Xu, Zhenggang

    2014-06-01

    Between December 2011 and March 2012, the reproductive characteristics of Microtus fortis reared in the laboratory at different population densities were assessed. In all, 258 male and female voles were randomly divided into 4 groups and reared at densities of 2, 4, 6, and 8 animals per cage (sex ratio: 1:1). The results showed that the pregnancy rate (?2 = 21.671, df = 3, P < 0.001) and first farrowing interval (F = 12.355, df = 3, P < 0.001) were significantly different among the different population density groups, but the mean litter size (mean ± SD) was not (F = 2.669, df = 3, P > 0.05). In particular, the reproductive index and sex hormone levels showed a significant difference among the different density groups studied. PMID:24873906

  15. Forty- Versus 20-Minute Trials of the Maintenance of Wakefulness Test Regimen for Licensing of Drivers

    PubMed Central

    Arzi, Limor; Shreter, Roni; El-Ad, Baruch; Peled, Ron; Pillar, Giora

    2009-01-01

    Study Objectives: Objective assessment of the ability to maintain wakefulness, although very important, is still equivocal. A recent study from our lab has shown that the Maintenance of Wakefulness Test (MWT), when performed with the 20-minute protocol (MWT20), is unreliable in assessing patients who are highly motivated to maintain wakefulness. In this study, we sought to examine whether the 40-minute protocol (MWT40) is a better tool in assessing such individuals. Methods: One hundred sixty-four consecutive subjects referred to our sleep lab by the Medical Institute for Driving Safety were studied. All subjects underwent a full-night polysomnogram followed by an MWT, 4 trials of 40 minutes each. All subjects knew that if they failed the wakefulness test their driving license would be revoked. Results: Forty-one subjects out of 164 (25%) fell asleep at least once. Of 39 subjects with severe obstructive sleep apnea, (respiratory disturbance index > 40/h), 19 fell asleep (48.7%). Of 13 subjects with a minimum oxygen saturation level below 65%, 7 fell asleep (53%). In the MWT20, only 7% of patients with severe obstructive sleep apnea fell asleep at least once. Conclusions: We conclude that the MWT40 is superior to the MWT20 in detecting difficulties maintaining wakefulness in a highly motivated population. However, our results yield a significantly lower detection of difficulties maintaining wakefulness than those reported in healthy subjects, suggesting that the MWT40 is also highly affected by motivation. We believe that, for a highly motivated population (such as for a driver’s license validation), different average sleep-latency threshold should be used than in general population. Citation: Arzi L; Shreter R; El-Ad B; Peled R; Pillar G. Forty- versus 20-minute trials of the Maintenance of Wakefulness Test regimen for licensing of drivers. J Clin Sleep Med 2009;5(1):57-62. PMID:19317382

  16. Differential Expression of microRNAs in the Non-Permissive Schistosome Host Microtus fortis under Schistosome Infection

    PubMed Central

    Han, Yanhui; Zhang, Min; Hong, Yang; Fu, Zhiqiang; Yang, Jianmei; Tao, Jianping; Lin, Jiaojiao

    2013-01-01

    The reed vole Microtus fortis is the only mammal known in China in which the growth, development and maturation of schistosomes (Schistosoma japonicum) is prevented. It might be that the anti-schistosomiasis mechanisms of M. fortis associate with microRNA-mediated gene expression, given that the latter has been found to be involved in gene regulation in eukaryotes. In the present study, the difference between pathological changes in tissues of M. fortis and of mice (Mus musculus) post-schistosome infection were observed by using hematoxylin-eosin staining. In addition, microarray technique was applied to identify differentially expressed miRNAs in the same tissues before and post-infection to analyze the potential roles of miRNAs in schistosome infection in these two different types of host. Histological analyses showed that S. japonicum infection in M. fortis resulted in a more intensive inflammatory response and pathological change than in mice. The microarray analysis revealed that 162 miRNAs were expressed in both species, with 12 in liver, 32 in spleen and 34 in lung being differentially expressed in M. fortis. The functions of the differentially expressed miRNAs were mainly revolved in nutrient metabolism, immune regulation, etc. Further analysis revealed that important signaling pathways were triggered after infection by S. japonicum in M. fortis but not in the mice. These results provide new insights into the general mechanisms of regulation in the non-permissive schistosome host M. fortis that exploits potential miRNA regulatory networks. Such information will help improve current understanding of schistosome development and host–parasite interactions. PMID:24391986

  17. Neutron capture therapy: Years of experimentation---Years of reflection

    SciTech Connect

    Farr, L.E.

    1991-12-16

    This report describes early research on neutron capture therapy over a number of years, beginning in 1950, speaking briefly of patient treatments but dwelling mostly on interpretations of our animal experiments. This work carried out over eighteen years, beginning over forty years ago. Yet, it is only fitting to start by relating how neutron capture therapy became part of Brookhaven`s Medical Research Center program.

  18. "Fortis/Lenis" Revisited One More Time: The Aerodynamics of Some Oral Stop Contrasts in Three Continents

    ERIC Educational Resources Information Center

    Butcher, Andrew

    2004-01-01

    The terms "fortis" and "lenis" are variously regarded as having one single underlying phonetic correlate or many. An exploratory analysis of acoustic and aerodynamic data on contrasting stop series in a number of European and non-European languages confirms that a significant variation in peak intra-oral pressure and in articulatory stricture…

  19. Far-UV observations of comet C/2012 S1 (ISON) with FORTIS

    NASA Astrophysics Data System (ADS)

    McCandliss, Stephan R.; Feldman, Paul D.; Weaver, Harold A.; Fleming, Brian; Redwine, Keith; Li, Mary J.; Kutyrev, Alexander; Moseley, Samuel H.

    2015-01-01

    Far-UV imagery and objective grating spectroscopy of comet C/2012 S1 (ISON) were acquired from NASA sounding rocket 36.296 UG, launched on 20 November 2013 at 04:40 MST (20.48 Nov 2013 UT), 8.32 days pre-perihelion, from the White Sands Missile Range, NM. The comet was 0.1° below ground horizon, 0.44 AU from the Sun, 0.86 AU from the Earth, and at a solar elongation of 26.3°. The payload reached an apogee of 279 km and the total time pointed at the comet was 353 s. At the time of launch ISON was undergoing a factor of 5 increase in water production rate, going from 3.5e29 to 19.6e29 molecules s-1between 19.6 and 21.6 Nov (Combi et al. 2014), marking what is thought to be a final fragmentation event (Sekanina & Kracht 2014). Our instrument, a wide-field multi-object spectro-telescope called FORTIS (Far-UV Off Rowland-circle Telescope for Imaging and Spectroscopy), observed Ly? emissions in an objective grating mode through an open microshutter array, developed at the Goddard Space Flight Center, over a (1/2°)2 field-of-view. After accounting for slit losses and deadtime corrections we find a preliminary lower limit to the Ly? surface brightness of ~ 400 kilorayleighs, yielding a hydrogen production rate of QH ~ 5e29 atoms s-1, in reasonable agreement with the Combi result. We also acquired a broadband image of the comet in the 1280 to 1900 Å bandpass. This image shows a drop in count rate proportional to altitude caused by increased absorption of cometary emissions by terrestrial O2 located in the lower thermosphere. O2 absorption acts as a selective time dependent filter that attenuates cometary emissions from different atomic and molecular species at different rates during descent. Preliminary analysis suggests that the dominant species in a (1e5 km)2 nuclear region is neutral carbon. The radial profile in comparison to a Haser model suggests that the C parent molecule had a lifetime (at 1 AU) ~ 105 s; much shorter than the expected lifetime of CO. We conclude there was little CO produced from the interior volume that was exposed during the final fragmentation of this dynamically new comet, in accord with the low CO production rate derived from HST/COS spectra obtained on 1 November 2013 (Weaver et al. 2014).

  20. The Forty-Eight-Hour Rule: Emotional Engagement and the Student Athlete

    ERIC Educational Resources Information Center

    Mueller, Alan C. R.

    2009-01-01

    Several years ago, the author taught a course called First-Year experience. A student named Sean mentioned that he played "water pong." Sean, a high-achieving student who was also a member of the lacrosse team, explained that water pong was a game with the rules of beer pong, using water rather than beer. Sean volunteered an explanation of his…

  1. Acute myeloid leukemia with two philadelphia chromosomes in forty-six stemline

    Microsoft Academic Search

    M. Hussein Khan; Zentrum der Inneren; Medizin der Johann; Wolfgang Goethe-Universitgt

    1973-01-01

    Serial cytogenetic studies of bone marrow in a 59-year-old male with a 14-month history of acute myeloid leukemia revealed a Ph1 disomic diploid clone (46, XY, 2Ph1). This clone responded to a cytostatic drug regimen of prednisone, vincristine and daunomycine. A dual population of normal and leukemic cells was observed during the course the disease.

  2. 40 years of neutrino physics

    NASA Astrophysics Data System (ADS)

    Reines, Frederick

    Wolfgang Pauli and Enrico Fermi pioneered the hypothesis and characteristics of the weak interaction and the elementary particle called the neutrino. Since its discovery some forty years ago the neutrino has been shown to be a fundamental constituent of matter with a surprisingly rich, and in very many ways unexpected, set of characteristics ranging from basic roles in the generation of energy in the sun to supernovæ.

  3. Effective Management of Trigeminal Neuralgia by Neurostimulation

    PubMed Central

    Abd-Elsayed, Alaa A.; Grandhi, Ravi; Sachdeva, Harsh

    2015-01-01

    Background Treatment of trigeminal neuralgia can be challenging for many physicians; patients who do not respond to conventional treatments and traditional surgical approaches often continue to suffer with pain. The peripheral nerve stimulator (PNS) has been used to treat many chronic pain conditions, but few reports exist about its use to treat trigeminal neuralgia. Case Report We present the case of a patient with trigeminal neuralgia resistant to conventional techniques of pain management. Conservative pain management was attempted but was ineffective. As a result, a PNS was placed with minimally invasive surgery. Pain scores were recorded before and after the procedure, and the patient reported complete resolution of her pain. Conclusion PNS implantation can be a safe and effective method to treat trigeminal neuralgia. More research is needed to define its mechanism of action.

  4. Sexual Complaints, Pelvic Floor Symptoms, and Sexual Distress in Women over Forty

    PubMed Central

    Knoepp, Leise R.; Shippey, Stuart H.; Chen, Chi Chiung Grace; Cundiff, Geoffrey W.; Derogatis, Leonard R.; Handa, Victoria L.

    2011-01-01

    Introduction The American Psychiatric Association recommends considering sexually related personal distress when assessing female sexual dysfunction. Currently, there is little data regarding the impact of sexual complaints on sexual distress. Aim To investigate the association between sexual complaints and perceived sexual distress in a population of ambulatory adult women. Methods Using the short forms of the Personal Experiences Questionnaire and Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire, we assessed sexual complaints among 305 women seeking outpatient gynecologic care. Depressive symptoms were quantified using the Center for Epidemiologic Studies Depression (CESD) score. Sexual distress was measured using the Female Sexual Distress Scale (FSDS). Using multivariable logistic regression, we compared sexual complaints between distressed and nondistressed women. Main Outcome Measures Sexual distress, defined by FSDS score ?15. Results FSDS scores were available for 292/305 participants. Seventy-six (26%) scores reflected distress. Distressed women were more likely to be younger (55.2 ± 1.0 years vs. 56.7 ± 0.8 years, P = 0.017); have higher CESD scores (16.6 vs. 9.5, P = 0.001); and report decreased arousal (56.8% vs. 25.1%, P = 0.001), infrequent orgasm (54% vs. 28.8%, P = 0.001), and dyspareunia (39.7% vs. 10.6%, P = 0.001). Women with sexual distress were also more likely to report sexual difficulty related to pelvic floor symptoms, including urinary incontinence with sexual activity (9% vs. 1.3%, P = 0.005), sexual avoidance due to vaginal prolapse (13.9% vs. 1%, P = 0.001), or sexual activity restriction due to fear of urinary incontinence (14.9% vs. 0.5%, P = 0.001). After multivariate analysis, sexual distress was significantly associated with dyspareunia (odds ratio [OR] 3.11, P = 0.008) and depression score (OR 1.05, P = 0.006), and inversely associated with feelings of arousal during sex (OR 0.19, P = 0.001). Conclusion Our results indicate that sexually related personal distress is significantly associated with dyspareunia, depressive symptoms, and decreased arousal during sexual activity. This contributes to our understanding of how sexual complaints may adversely affect women’s quality of life. PMID:20704643

  5. Forty-Fourth Annual Report of the National Advisory Committee for Aeronautics Administrative Report Including Technical Reports Nos. 1342 to 1392

    NASA Technical Reports Server (NTRS)

    1959-01-01

    In accordance with act of Congress, approved March 3, 1915, as amended (U.S.C., title 50, .sw 151), which established the National Advisory Committee for Aeronautics, the Committee submits its Forty-fourth Annual Report for the fiscal year 1958. This is the Committee's final report to the Congress. The National Aeronautics and Space Act of 1958 (Public Law 85-568) provides in section 301 that the NACA "shall cease to exist" and "all functions, powers, duties, and obligations, and all real and personal property, personnel (other than members of the Committee), funds, and records of the NACA shall be transferred to the National Aeronautics and Space Administration. The aforesaid act provides that "this section shall take effect 90 days after the date of the enactment of this act, or on any earlier date on which the Administrator shall determining and announce by proclamation published in the Federal Register, that the Administration has been organized and is prepared to discharge the duties and exercise the power conferred upon it by this act." The Administrator, Hon. T. Keith Glennan has advised the Committee of his intention to issue such proclamation, effective October 1,1958.

  6. Digital Archives - Thomas M. Bown's Bighorn Basin Maps: The Suite of Forty-Four Office Master Copies

    USGS Publications Warehouse

    McKinney, Kevin C.

    2001-01-01

    This CD-ROM is a digitally scanned suite of master 'locality' maps produced by Dr. Thomas M. Bown. The maps are archived in the US Geological Survey Field Records. The maps feature annual compilations of newly established fossil (nineteen 7.5 degree maps) of central basin data collections. This master suite of forty-four maps represents a considerably broader geographic range within the basin. Additionally, three field seasons of data were compiled into the master suite of maps after the final editing of the Professional Paper. These maps are the culmination of Dr. Bown's Bighorn Basin research as a vertebrate paleontologist for the USGS. Data include Yale, Wyoming, Duke, Michigan and USGS localities. Practical topographic features are also indicated, such as jeep=trail access, new reservoirs, rerouted roadbeds, measured sections, fossil reconnaissance evaluations (G=good, NG=no good and H=hideous), faults, palcosol stages, and occasionally 'camp' vernacular for locality names.

  7. Forty Years of Excellence and Beyond. Proceedings of the Annual North East Association for Institutional Research (NEAIR) Conference (40th, Newport, Rhode Island, November 9-12, 2013)

    ERIC Educational Resources Information Center

    Parker, Tiffany, Ed.

    2013-01-01

    The NEAIR 2013 Conference Proceedings is a compilation of papers presented at the Newport, Rhode Island, conference. Papers in this document include: (1) Aspiring to the Role of "Data Badass:" Some Thoughts on the Political Context of IR (Mark Freeman); (2) Data-Driven Internal Benchmarks and Successful Learning Outcomes (Mamta Saxena…

  8. MD Management Ltd, a Canadian Medical Association (CMA) company, has been assisting Medical Students and Residents for the last forty years by providing objective

    E-print Network

    MacMillan, Andrew

    MD Management Ltd, a Canadian Medical Association (CMA) company, has been assisting Medical as a benefit of being a CMA member. Common issues & concerns during Medical School & Residency: Debt Financial Consultant any time at: E-mail: abel.tsang@cma.ca Phone: (780) 436-1333 Toll-free: 1 877 434

  9. Treatment of Failed Back Surgery Syndrome in a Forty-Three-Year-Old Man With High-Dose Oxycodone/Naloxone

    PubMed Central

    Bujedo, Borja Mugabure

    2015-01-01

    Introduction: Failed back surgery syndrome (FBSS) is an increasing cause of chronic pain in most countries. This poses high costs to both patients and National Health Organizations. Case Presentation: In this report, multimodal pain management based on daily high-dose oxycodone/naloxone (OXN 180/90 mg) led to reduced patient's pain score and improved quality of life. Conclusions: Oxycodone/naloxone can be a good alternative for the management of FBSS when other interventional or pharmacologic strategies have failed. In this case report, higher doses than those recommended as a maximum daily ceiling (80/40 mg) were safely used in one selected patient with noncancer severe pain. PMID:25893186

  10. Puzzlemaking and Part-Whole Perception of Two-Year-Old and Four-Year-Old Children

    ERIC Educational Resources Information Center

    Montford, Emily I. Purvis; Readdick, Christine A.

    2008-01-01

    The relationship between preschoolers' puzzlemaking strategies and part-whole perception was investigated in the present study. Forty-eight two year olds and 48 four year olds were randomly selected from eight licensed childcare centers. Puzzlemaking strategies (image, form, color, and trial and error) were measured by performance in the…

  11. Kainji resettlement housing: 40 years later

    Microsoft Academic Search

    Ruth Shinenge Gyuse; Timothy Terver Gyuse

    2008-01-01

    Nigeria's Kainji Dam, completed in 1968, displaced 44,000 people from 239 settlements. Three housing forms were designed to provide for urban, semi?urban, and rural settings, respectively. Forty years later, the urban and semi?urban forms are integrated into the community while the rural form, modeled after a grain storage structure (rumbu) has been less successful. Five lessons are derived from this

  12. Revisiting First-Year Teacher Burnout: New South Carolina Educators in the Era of Accountability

    ERIC Educational Resources Information Center

    Ilagan, Daniel J.

    2010-01-01

    Forty-six percent of the nation's teachers are expected to leave the profession by their fifth year in the classroom. This alarming statistic has grabbed the attention of federal, state, and local leaders. In South Carolina alone, 28,500 teachers left the profession in the last five years, or an average of 5,700 per year. This translates to a…

  13. Early prediction of renal allograft loss beyond one year

    Microsoft Academic Search

    David Nicol; Allan S. MacDonald; Joseph Lawen; Philip Belitsky

    1993-01-01

    Despite significant improvements in the results of renal transplantation since the introduction of cyclosporin, graft loss beyond the 1st year remains a significant and unresolved problem. In a retrospective analysis, 348 cyclosporin-treated renal transplant recipients with a functioning graft at 12 months were studied. Forty-eight patients in whom graft failure occurred in the 2nd and 3rd years were compared to

  14. Commitment to the Core: A Longitudinal Analysis of Humanities Degree Production in Four-Year Colleges

    ERIC Educational Resources Information Center

    Hearn, James C.; Belasco, Andrew S.

    2015-01-01

    As many national commissions and observers have noted, the past forty years have brought unprecedented declines in humanities enrollments and programs in U.S. higher education. These changes are particularly striking in the iconic academic heart of the enterprise, the four-year college sector, where many institutions have diversified curricular…

  15. Reduction of the nosocomial meticillin-resistant Staphylococcus aureus incidence density by a region-wide search and follow-strategy in forty German hospitals of the EUREGIO, 2009 to 2011.

    PubMed

    Jurke, A; Kock, R; Becker, K; Thole, S; Hendrix, R; Rossen, J; Daniels-Haardt, I; Friedrich, Aw

    2013-01-01

    Meticillin-resistant Staphylococcus aureus (MRSA) disseminates between hospitals serving one patient catchment area. Successful prevention and control requires concerted efforts and regional surveillance. Forty hospitals located in the German EUREGIO have established a network for combating MRSA. In 2007 they agreed upon a synchronised strategy for screening of risk patients and a standard for transmissionbased precautions (search and follow). The same year, the hospitals started synchronised MRSA prevention and annually reporting MRSA-data to the public health authorities. The median rate of screening cultures per 100 patients admitted increased from 4.38 in 2007 to 34.4 in 2011 (p<0.0001). Between 2007 and 2011, the overall incidence density of MRSA (0.87 MRSA cases/1,000 patient days vs 1.54; p<0.0001) increased significantly. In contrast, both the incidence density of nosocomial MRSA cases (0.13 nosocomial MRSA cases/1,000 patient days in 2009 vs 0.08 in 2011; p=0.0084) and the MRSA-days-associated nosocomial MRSA rate (5.51 nosocomial MRSA cases/1,000 MRSA days in 2009 vs 3.80 in 2011; p=0.0437) decreased significantly after the second year of the project. We documented adherence to the regional screening strategy resulting in improved detection of MRSA carriers at admission. Subsequently, after two years the nosocomial MRSA-incidence density was reduced. Regional surveillance data, annually provided as benchmarking to the regional hospitals and public health authorities, indicated successful prevention. PMID:24079380

  16. Brown at Forty: Six Visions.

    ERIC Educational Resources Information Center

    Neuborne, Burt

    1995-01-01

    "Brown v. Board of Education of Topeka, Kansas" called the United States to a new level of moral consciousness. Current efforts to denigrate "Brown" as a failure overlook its effect as a social catalyst for movement toward equality. Six visions of "Brown" examine its contemporary meaning (triumph, aspiration, catalyst, failure, challenge, and…

  17. FORTY-FIFTH DOCTORAL COMMENCEMENT

    E-print Network

    Dennehy, John

    chapters. His early work focused on the South, examining slavery as an economic and social system; Slavery and Freedom: An Interpretation of the Old South; and The Radical and the Republican: Frederick. Uh-oh, I thought. I write about slavery and antislavery and the comin

  18. A Century of Change: The History of Two-Year Education in the State of Alabama, 1866-1963

    ERIC Educational Resources Information Center

    Smith, Dustin P.

    2012-01-01

    Much has been written about two-year education in Alabama during the governorships of George C. Wallace, but little about two-year education prior to his first inauguration in 1963. Yet nearly a third of the forty-three junior, technical, and community college institutions that eventually formed the Alabama Community College System had been…

  19. Light Years

    NSDL National Science Digital Library

    2007-08-09

    This video segment adapted from Shedding Light on Science describes how astronomical distances can be measured in units of light-years, and how the finite speed of light allows astronomers to study how the universe looked long ago.

  20. Integrating Geographic Information Systems and Remote Sensing for Technical Workforce Training at Two-Year Colleges

    ERIC Educational Resources Information Center

    National Council for Geographic Education (NJ1), 2006

    2006-01-01

    This report examines the outcomes of a workshop held at the National Science Foundation on August 15-16, 2005. Forty-six participants, representing academia, industry, government agencies, professional associations, and special projects met to: (1) discuss how geospatial technology training at two-year colleges can address workforce needs; and…

  1. A Study of First-Year Chemistry Students' Understanding of Solution Concentration at the Tertiary Level

    ERIC Educational Resources Information Center

    de Berg, Kevin

    2012-01-01

    This paper reports on students' understanding of sugar concentration in aqueous solutions presented in two different modes: a visual submicroscopic mode for particles and a verbal mode referring to macroscopic amounts of sugar. One hundred and forty-five tertiary college students studying some form of first-year chemistry participated in the…

  2. RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life

    Microsoft Academic Search

    U. Schauer; S. Hoffjan; J. Bittscheidt; A. Kochling; S. Hemmis; S. Bongartz; V. Stephan

    2002-01-01

    Severe respiratory syncytial virus (RSV) infection has been hypothesised to be a risk factor for the development of allergy and asthma, but epidemiological studies in older children have been inconclusive. The current study hypothesises that the effect of RSV bronchiolitis might be most prominent during the first year after bronchiolitis. Forty-two infants had experienced RSV bronchiolitis severe enough to cause

  3. Counselling for prenatal diagnosis of sickle cell disease and beta thalassaemia major: a four year experience

    Microsoft Academic Search

    E N Anionwu; N Patel; G Kanji; H Renges; M Brozovi?

    1988-01-01

    A non-directive programme of prenatal counselling was used during a four year period. Forty-three couples at risk for having a baby with a haemoglobinopathy were identified. Prenatal diagnosis was offered in 19 pregnancies to 14 couples at risk of having a baby with sickle cell anaemia and in two pregnancies in two couples at risk of a baby with beta

  4. Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator

    E-print Network

    Theogarajan, Luke

    A wirelessly operated, minimally invasive retinal prosthesis was developed for preclinical chronic implantation studies in Yucatan minipig models. The implant conforms to the outer wall of the eye and drives a microfabricated ...

  5. Comparison of two neurostimulation techniques for axillary brachial plexus blockade

    Microsoft Academic Search

    D. M. Coventry; K. F. Barker; M. Thomson

    2001-01-01

    This prospective, randomized, double-blind study compared two techniques of axillary brachial plexus block using a peripheral nerve stimulator. Both groups received initial musculo- cutaneous nerve block followed by either a single injection on median nerve stimulation (group 1) or a double injection divided between median and radial nerves (group 2). All 60 patients received a total of 30 ml of

  6. Years ago

    Microsoft Academic Search

    Karen V. H. Parshall

    1991-01-01

    It is now 60 years since Kurt G6del published his remarkable discoveries on incompleteness. These discoveries changed the face of mathematical logic and, in large measure, discredited two of the three philosophies of mathematics that were prominent at the time: Hilbert's formalism and Russell's logicism. Hilbert's program was discredited by showing that to prove an axiom system consistent requires a

  7. Partnering To Build a Quality Workforce: Critical Issues in Environmental Technology Education at Two-Year Colleges. A Report of the National Forum on Critical Issues in Environmental Technology Education at Two-Year Colleges (Washington, D.C., March 2-4, 1995).

    ERIC Educational Resources Information Center

    Kabat, Ellen J.; Friedel, Janice Nahra; Senew, Mike

    The National Forum on Critical Issues in Environmental Technology Education at Two-Year Colleges addressed critical issues relevant to environmental technology education in the United States. Forty-three participants from across the country who attended the 1995 Forum represented business and industry, two-year colleges, four-year colleges and…

  8. Padian, K. and Olsen, P.E., 1989, Baird's two axioms of vertebrate paleoichnology. Abstract of Papers, Forty-Ninth Annual Meeting Society of Vertebrate Paleontology, Journal of Vertebrate Paleontology, Vol. 9, No. 3, Supplement., p. 34A-35A.

    E-print Network

    Olsen, Paul E.

    of Papers, Forty-Ninth Annual Meeting Society of Vertebrate Paleontology, Journal of Vertebrate Paleontology OF VERTEBRATE SCALES AND TEETII: CONODONTS AS THE FIRST CRANlATES NELMS, L Gayle, Dept. of Paleontology, Univ NELMS, L. Gayle, Dept. of Paleontology, Univ. of California, Berkeley, CA 94720 Vertebrate fossils from

  9. Physiological and Behavioral Regulation in Two-Year-Old Children with Aggressive\\/Destructive Behavior Problems

    Microsoft Academic Search

    Susan D. Calkins; Susan E. Dedmon

    2000-01-01

    A sample of 99 two-year-old children was selected on the basis of parents' responses to two administrations of the Child Behavior Checklist for two- to three-year-olds. Forty-nine of these children displayed symptoms of aggressive\\/destructive (externalizing) problems that were in the borderline clinical range (labelled “high risk”) and 50 children displayed few such symptoms (“low risk”). The children were assessed in

  10. Endoscopic excision of an eroding calcified mesh sling, 10 years after primary surgery

    Microsoft Academic Search

    Bassem S. Wadie

    2009-01-01

    Management of urethral erosion typically entails two options: sling incision (in the early postoperative period) or excision\\u000a of the suburethral part of the sling (urethrolysis). This paper describes a different endoscopic technique. A forty-year-old\\u000a woman with a synthetic sling implanted 10 years prior presented with persistent lower urinary tract symptoms. A kidney ureter\\u000a bladder X-ray showed a stone at the level

  11. A 600-year tree-ring fire history from Norra Kvills National Park, southern Sweden: implications for conservation strategies in the hemiboreal zone

    Microsoft Academic Search

    Mats Niklasson; Börje Drakenberg

    2001-01-01

    The fire history of Norra Kvills National Park in southeastern hemiboreal Sweden was reconstructed for the last 600 years by cross-dating of fire scars in trees, stumps and snags of Scots pine (Pinus sylvestris). Between 1401 and 1770 forty different fires were recorded; fire frequency at point scale was 20 years, which is 3–4 times more frequent than in northern

  12. Cardiopulmonary resuscitation performance of subjects over forty is better following half-hour video self-instruction compared to traditional four-hour classroom training

    Microsoft Academic Search

    Anne M. Batcheller; Robert T. Brennan; Allan Braslow; Alejando Urrutia; William Kaye

    2000-01-01

    Cardiopulmonary resuscitation (CPR) training is not well targeted to family members of individuals at highest risk of cardiac arrest. Participants in traditional CPR classes (TRAD) average 31 years of age, while family members of cardiac patients average 55 years. Video self-instruction (VSI) can reach older individuals and others who do not participate in TRAD classes. VSI is a combination of

  13. 26 CFR 7.48-2 - Election of forty-percent method of determining investment credit for movie and television films...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...investment credit for movie and television films placed in service in a taxable year beginning...investment credit for movie and television films placed in service in a taxable year beginning...taxpayers who placed movie or television films (here- inafter referred to as...

  14. 26 CFR 7.48-2 - Election of forty-percent method of determining investment credit for movie and television films...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...investment credit for movie and television films placed in service in a taxable year beginning...investment credit for movie and television films placed in service in a taxable year beginning...taxpayers who placed movie or television films (here- inafter referred to as...

  15. 26 CFR 7.48-2 - Election of forty-percent method of determining investment credit for movie and television films...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...investment credit for movie and television films placed in service in a taxable year beginning...investment credit for movie and television films placed in service in a taxable year beginning...taxpayers who placed movie or television films (here- inafter referred to as...

  16. Changing Parent Attitudes and Improving Language and Intellectual Abilities of Culturally Disadvantaged Four-Year-Old Children Through Parent Involvement.

    ERIC Educational Resources Information Center

    McCarthy, Janet Lee Gorrell

    The purposes of this study were to analyze parent involvement as it related to (1) the development of language abilities of culturally disadvantaged preschool children and (2) the intelligence test scores of these children and to analyze parent attitudes resulting from involvement. Nine hypotheses were tested. Forty-one 4-year-old Head Starters in…

  17. W.K.H. Panofsky Prize in Experimental Particle Physics Talk: 40 Years of Neutrino Physics--A Personal History

    NASA Astrophysics Data System (ADS)

    Beier, Eugene

    2010-02-01

    In the past forty years neutrino physics has made great advances. Some of the steps and missteps that were taken on the path from the 1960's to the present will be discussed. Particular attention will be given to the development of solar neutrino physics. )

  18. Lone atrial fibrillation: Prognostic differences between paroxysmal and chronic forms after 10 years of follow-up

    Microsoft Academic Search

    Sabino Scardi; Carmine Mazzone; Claudio Pandullo; Daniela Goldstein; Angela Poletti; Franco Humar

    1999-01-01

    Background Lone atrial fibrillation (LAF) is defined by the presence of atrial fibrillation unassociated with other evidence of organic heart disease. There are conflicting data concerning the prognostic importance, rate of embolic complications, and survival in subjects affected by this arrhythmia. Methods and Results One hundred forty-five patients younger than 50 years at the time of the first diagnosis were

  19. Faculty Academic Advising: An Examination of Students' and Faculty Members' Perception of a First-Year Experience.

    ERIC Educational Resources Information Center

    Jones, Gwendolyn

    Spring 1998 surveys of faculty and students at University of Akron, Community and Technical (C&T) College (Ohio) queried respondents regarding their first-year experience with a faculty academic advising project. Forty of the 72 (55%) full-time C&T faculty responded, and 279 of 400 (70%) student surveys were returned. Faculty findings included:…

  20. Where "Sign Language Studies" Has Led Us in Forty Years: Opening High School and University Education for Deaf People in Viet Nam through Sign Language Analysis, Teaching, and Interpretation

    ERIC Educational Resources Information Center

    Woodward, James; Hoa, Nguyen Thi

    2012-01-01

    This paper discusses how the Nippon Foundation-funded project "Opening University Education to Deaf People in Viet Nam through Sign Language Analysis, Teaching, and Interpretation," also known as the Dong Nai Deaf Education Project, has been implemented through sign language studies from 2000 through 2012. This project has provided deaf adults in…

  1. Revision of the Agathidinae (Hymenoptera, Braconidae) of Vietnam, with the description of forty-two new species and three new genera

    PubMed Central

    van Achterberg, Cornelis; Long, Khuat Dang

    2010-01-01

    Abstract The species of seventeen genera of Agathidinae (Braconidae) from Vietnam are revised: Agathis Latreille, 1804, Bassus Fabricius, 1804; Biroia Szépligeti, 1900; Braunsia Kriechbaumer, 1894; Camptothlipsis Enderlein, 1920; Coccygidium de Saussure, 1892; Coronagathis gen. n. (type species: Coronagathis cornifera sp. n.); Cremnops Foerster, 1862; Disophrys Foerster, 1862; Earinus Wesmael, 1837; Euagathis Szépligeti, 1900; Gyragathis gen. n. (type species: Gyragathis quyi sp. n.), Gyrochus Enderlein, 1920; Lytopylus Foerster, 1862; Therophilus Wesmael, 1837; Troticus Brullé, 1846, and Zelodia gen. n. (type species: Zelomorpha varipes van Achterberg & Maetô, 1990). Keys to the Vietnamese species are given. Sixty-five species are recognised, of which twelve species are newly recorded for Vietnam: Bassus albifasciatus (Watanabe, 1934), Coccygidium angostura (Bhat & Gupta, 1977), Cremnops atricornis (Smith, 1874), stat. n., Disophrys erythrocephala Cameron, 1900, Gyrochus yunnanensis Wang, 1984, Lytopylus romani (Shestakov, 1940), comb. n., Therophilus festivus (Muesebeck, 1953), comb. n., Therophilus javanus (Bhat & Gupta, 1977), comb. n., Therophilus lienhuachihensis (Chou & Sharkey, 1989), comb. n., Therophilus marshi (Bhat & Gupta, 1977), comb. n., Zelodia absoluta (Chen & Yang, 1998), comb. n. and Zelodia longidorsata (Bhat & Gupta, 1977), comb. n. Forty-two species are new to science: Agathis citrinisoma sp. n., Bassus albobasalis sp. n., Bassus albozonatus sp. n., Biroia soror sp. n., Braunsia bicolorata sp. n., Braunsia devriesi sp. n., Braunsia maculifera sp. n., Braunsia nigrapiculata sp. n., Braunsia pumatica sp. n., Camptothlipsis hanoiensis sp. n., Coronagathis cornifera sp. n., Earinus aurantius sp. n., Earinus brevistigmus sp. n., Euagathis flavosoma sp. n., Disophrys maculifera sp. n., Disophrys quymanhi sp. n., Disophrys rhinoides sp. n., Gyragathis quyi sp. n., Therophilus annuliferus sp. n., Therophilus cattienensis sp. n., Therophilus contrastus sp. n., Therophilus crenulisulcatus sp. n., Therophilus depressiferus sp. n., Therophilus elongator sp. n., Therophilus levisoma sp. n., Therophilus marucae sp. n., Therophilus mellisoma sp. n., Therophilus nigrolineatus sp. n., Therophilus nuichuaensis sp. n., Therophilus parasper sp. n., Therophilus planifrons sp. n., Therophilus punctiscutum sp. n., Therophilus robustus sp. n., Therophilus rugosiferus sp. n., Therophilus scutellatus sp. n., Troticus alloflavus sp. n., Troticus giganteus sp. n., Zelodia albobasalis sp. n., Zelodia anginota sp. n., Zelodia bicoloristigma sp. n., Zelodia brevifemoralis sp. n. and Zelodia flavistigma sp. n. The following new synonyms are proposed: Euagathis nigrithorax Bhat & Gupta, 1977, Euagathis variabilis Enderlein, 1920, Euagathis variabilis var. tibialis Enderlein, 1920, Euagathis variabilis var. melanopleura Enderlein, 1920 and Euagathis variabilis var. sucarandana Enderlein, 1920 with Euagathis abbotti (Ashmead, 1900); Euagathis jinshanensis Chen & Yang, 2006 and Euagathis sharkeyi Chen & Yang, 2006, with Euagathis forticarinata (Cameron, 1899). The genus Amputostypos Sharkey, 2009, is synonymised with Coccygidium de Saussure, 1892, syn. n. The following new combinations are given: Bassus subrasa (Enderlein, 1920), comb. n., Gyragathis angulosa (Bhat & Gupta, 1977), comb. n., Lytopylus romani (Shestakov, 1940), comb. n., Therophilus annulus (Chou & Sharkey, 1989), comb. n., Therophilus asper (Chou & Sharkey, 1989), comb. n., Therophilus cingulipes (Nees, 1812), comb. n., Therophilus daanyuanensis (Chen & Yang, 2006), comb. n., Therophilus fujianicus (Chen & Yang, 2006), comb. n., Therophilus javanus (Bhat & Gupta, 1977), comb. n., Therophilus lanyuensis (Chou & Sharkey, 1989), comb. n., Therophilus luzonicus (Bhat & Gupta, 1977), comb. n., Therophilus muesebecki (Bhat & Gupta, 1977), comb. n., Therophilus rudimentarius (Enderlein, 1920), comb. n., Therophilus similis (Bhat & Gupta, 1977), comb. n., Therophilus sungkangensis (Chou & Sharkey, 1989), comb. n., Therophilus tanycoleosus (Chen & Yang, 2006

  2. Persistence/Attrition: A Longitudinal Study of the Freshman Class of 1974. Indiana Studies in Higher Education Number Forty-One.

    ERIC Educational Resources Information Center

    Brigman, S. Leellen; Jacobs, Lucy Cheser

    The persistence of the freshman class (5,052 students) of 1974 at Indiana University's Bloomington campus was investigated. The students were classified into three groups according to their enrollment status in the fall of 1976. Two-thirds were persisters who were enrolled for their third academic year. Among the students who were no longer…

  3. The Economic Benefits of Reducing the Dropout Rate for Students of Color in the Nation's Forty-Five Largest Metropolitan Areas. Summary of Findings

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    Years of data have consistently underscored the persistent graduation gap between America's students of color and their peers. The most recent estimate shows that high school graduation rates for African American, Latino, and American Indian students hover only slightly higher than 50 percent. This is more than 20 percentage points lower than that…

  4. 15 Years of Terra, 14 Years of Application Usage

    NASA Astrophysics Data System (ADS)

    Schmaltz, J. E.; Alarcon, C.; Boller, R. A.; Cechini, M. F.; Davies, D.; Fu, G.; Gunnoe, T.; Hall, J. R.; Huang, T.; Ilavajhala, S.; Jackson, M.; King, J.; McGann, M.; Murphy, K. J.; Roberts, J. T.; Thompson, C. K.; Ye, G.

    2014-12-01

    The instruments onboard the Terra spacecraft were designed for long-term Earth science research but not long after launch it became apparent that this data and imagery could be made available in near real-time for applications users. During the year 2000 fire season in the western United States, the US Forest Service approached NASA with a request to expedite MODIS fire detections. The Rapid Response system was created to generate fire detections as well as true color imagery in both swath and geo-referenced formats. This imagery was used by a wide variety of applications, such as NASA's AERONET program, the USDA Foreign Agricultural Service, Antarctic resupply shipping, flood mapping for relief agencies, Deepwater Horizon monitoring, volcanic ash monitoring, as well as print, televised, and Internet media. From 2004, the University of Maryland's Web Fire Mapper helped distribute fire detection information in a variety of formats. However, the applications community expressed the need for near-real time access to the underlying data. This requirement led to the development of the Land Atmosphere Near real-time Capability for EOS (Earth Observing System) (LANCE) in 2009. To achieve the latency requirements, many components of the EOS satellite operations, ground and science processing systems had to be made more efficient. In addition, products that require ancillary data were modified to use alternate inputs. Forty Terra MODIS data products are currently available from LANCE. LANCE also includes data from other instruments including AIRS, AMSR-E, MLS, and OMI. To help near-real time users navigate this large data offering, a new imagery service was begun in 2011 - Global Imagery Browse Services (GIBS). This service provides very responsive viewing using the Web Map Tile Service protocol. These programs will continue to support and expand the use of Terra data for near-real time applications well into the future.

  5. Normative Data for the Words-in-Noise Test for 6- to 12-Year-Old Children

    ERIC Educational Resources Information Center

    Wilson, Richard H.; Farmer, Nicole M.; Gandhi, Avni; Shelburne, Emily; Weaver, Jamie

    2010-01-01

    Purpose: To establish normative data for children on the Words-in-Noise Test (WIN; R. H. Wilson, 2003; R. H. Wilson & R. McArdle, 2007). Method: Forty-two children in each of 7 age groups, ranging in age from 6 to 12 years (n = 294), and 24 young adults (age range: 18-27 years) with normal hearing for pure tones participated. All listeners were…

  6. Effects of the Emphasis on Achieving Adequate Yearly Progress on Teachers and Administrators at Schools under the Constraints of No Child Left Behind

    ERIC Educational Resources Information Center

    Fisher, Cathy Ann Burnett

    2010-01-01

    The purpose of this research was to study the effects of the emphasis on achieving Adequate Yearly Progress at elementary schools under the regulations of the No Child Left Behind legislation. Qualitative data were gathered through interviews with fifty educators: forty-three teachers and seven administrators. All of the educators worked at six…

  7. [Acute myocardial infarction in octogenarians treated by primary coronary angioplasty: in hospital outcome, social evolution and long-term mortality. About a forty-seven consecutive patients study].

    PubMed

    Jacquemin, L; Dezfouli, M-H; El Belghiti, R; Roth, O; Calatan, A; Levy, J; Monassier, J-P

    2007-11-01

    This study evaluated the hospital outcome of octogenarian patients treated by primary angioplasty for acute myocardial infarction less than 12 hours. The long-term mortality and social outcome were evaluated, social outcome was based on IADL and IADL-E scales corresponding to physical autonomy and level of dependence. We included from 1999 to 2005 47 old patients of 83.5+/-3.2 years. The reperfusion of the obstructed coronary artery was obtained in 45 patients (95.7%) with TIMI 3 flow. Hospital mortality was 25.5% and 4.2% without hemodynamic complication. A multivariate analysis identified a Killip score>1 as predictive factor of hospital mortality (OR=8.9 and p=0.05). The long-term survival without death with a follow-up of 26.3+/-18.3 months was 82.2% at 24 months and 70.6% at 48 months according to the Kaplan-Meier method. In an multivariate analysis, hospitalization exit without aspirine was associated with a higher long term mortality (OR=34.8 and p=0.04). According to the evolution of scores of IADL and IADL-E scales, patients had an excellent autonomy and good capacities before the infarction and they kept them on the long term. Thus octogenarians with acute myocardial infarction treated by primary angioplasty have a high in hospital and long term mortality but the survivors preserve an excellent daily autonomy. PMID:17920560

  8. Sustained suppression of neointimal proliferation by sirolimus-eluting stents: one-year angiographic and intravascular ultrasound follow-up

    Microsoft Academic Search

    J. E. Sousa; Langenhove van G. J. J; A. G. M. R. Sousa; R. Falotico; J. J. Popma; J. Jaeger; M. A. Costa; A. C. Abizaid; B. J. W. M. Rensing; L. F. Tanajura; K. Kozuma; P. W. J. C. Serruys

    2001-01-01

    BACKGROUND: We have previously reported a virtual absence of neointimal hyperplasia 4 months after implantation of sirolimus-eluting stents. The aim of the present investigation was to determine whether these results are sustained over a period of 1 year. METHODS AND RESULTS: Forty-five patients with de novo coronary disease were successfully treated with the implantation of a single sirolimus-eluting Bx VELOCITY

  9. Sustained Suppression of Neointimal Proliferation by Sirolimus-Eluting Stents One-Year Angiographic and Intravascular Ultrasound Follow-Up

    Microsoft Academic Search

    J. Eduardo Sousa; Marco A. Costa; Alexandre C. Abizaid; Benno J. Rensing; Andrea S. Abizaid; Luiz F. Tanajura; Ken Kozuma; Glenn Van Langenhove; Amanda G. M. R. Sousa; Robert Falotico; Judith Jaeger; Jeffrey J. Popma; Patrick W. Serruys

    Background—We have previously reported a virtual absence of neointimal hyperplasia 4 months after implantation of sirolimus-eluting stents. The aim of the present investigation was to determine whether these results are sustained over a period of 1 year. Methods and Results—Forty-five patients with de novo coronary disease were successfully treated with the implantation of a single sirolimus-eluting Bx VELOCITY stent in

  10. Foundation Year Aguideforstudents

    E-print Network

    Anderson, Jim

    Foundation Year Aguideforstudents #12;2 Contents TheFoundationYears 5 Engineering/Physics/Geophysics FoundationYear 6 ScienceFoundationYear 7 EntryRequirements 8 Moneymatters 10 Universitylife 10 TheUniversity 10 Thecity 10 Accommodation 10 Studentaccommodation MontefioreHouse4.. #12;3 OurFoundation

  11. Foundation Year Aguideforinternationalstudents

    E-print Network

    Molinari, Marc

    Foundation Year Aguideforinternationalstudents #12;2 Contents TheFoundationYears 5 Engineering/Physics/Geophysics FoundationYear 6 ScienceFoundationYear 7 EntryRequirements 8 Moneymatters 10 Universitylife 10 The-termcommitmentandabig investmentinyourfuture.OurFoundationYearsare designedtoprepareyouforundergraduatestudyandto

  12. One-year delayed recall performance of the Rey-Osterrieth Complex Figure in a healthy young adult sample.

    PubMed

    Yamashita, Hikari

    2009-01-01

    This study investigated the performance of the very long-term delayed recall trial (1 year) of the Rey-Osterrieth Complex Figure Test (ROCF) in a healthy young adult sample. Forty-one healthy university students were given the delayed recall trial, one year after receiving the copy and the 3-minutes delayed recall trial of the ROCF. Although a significant decrease of the recall score was shown by comparison with the 3-minutes delayed recall trial, all the participants were able to draw a certain figure including the main features of the ROCF on the 1-year delayed recall trial. PMID:19430996

  13. Georgio Forti Photosynthesis Research 60: 99110, 1999.

    E-print Network

    Govindjee "Gov"

    ; photophosphorylation; photosynthetic electron transport; thylakoids flavopro- tein Abstract The major theme of my work in photosynthesis has been electron transport in green plant thylakoids. In particular, we investigated the properties and the role of the NADP-reducing flavoprotein and its possible function in cyclic electron

  14. Forty five nanoseconds superconducting delay lines

    NASA Astrophysics Data System (ADS)

    Hohenwarter, G. K. G.; Track, E. K.; Drake, R. E.; Patt, R.

    1993-03-01

    The authors report on the design, simulation, fabrication, and measurement of very long superconducting coplanar waveguide delay lines on 3-in-diameter LaAlO3 substrates. Variations of the design involving the addition of a ground plane on the backside of the substrate and/or the use of gold wire-bond bridges to electrically connect the in-plane ground planes were investigated. A delay of 45 ns was measured for a line length of 4.3 m. The best response was obtained with wire-bond connections and no backside ground plane. A resonance-free insertion loss of less than 0.01 dB/ns was obtained with a 1.7-GHz bandwidth for NbN at 4.2 K. This is to be compared with a loss of 0.1 dB/ns for a 50-ns 0.141-in O.D. (outer diameter) copper coaxial delay line that weighs 1.5 lb and 0.02 dB/ns for a 60-ns 1-in O.D. copper coaxial delay line that weighs 45 lb.

  15. Life begins at forty: Microwave tubes

    Microsoft Academic Search

    J. M. Osepchuk

    1977-01-01

    The history of microwave tubes is reviewed from a philosophical viewpoint. An interesting part of this historical assessment is an examination of roles of technical forecasting and management planning. The definition of the microwave frequency range is presented and shown to support the primacy of tubes, or electron-beam devices, in a frequency range between those dominated by discrete solid-state devices

  16. Forty Meters from Entry to Victoria Crater

    NASA Technical Reports Server (NTRS)

    2007-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view is presented as a cylindrical projection with geometric seam correction.

  17. Ten-year prognosis for generalized infantile eczema.

    PubMed

    Linna, O; Kokkonen, J; Lahtela, P; Tammela, O

    1992-12-01

    Forty children treated in our hospital for generalized infantile eczema were re-examined at 11-13 years of age. In 7 (18%) children the eczema had disappeared and in 26 (65%) it had become less severe. Unrelated to dermatological status or gender, allergic rhinitis was diagnosed in 31 (78%) and asthma in 21 (53%) children. Only 8 children continued without either of these two conditions. All 32 children with allergic rhinitis and/or asthma showed at least one positive skin test reaction in a test panel of 11 common inhalant and food allergens compared with only 4 of 8 children without either allergic rhinitis or asthma (p < 0.001). Our results showed an improvement of dermatological status in most children with generalized infantile eczema but there was a high risk of a concomitant respiratory allergy and development of allergic rhinitis or asthma. PMID:1290844

  18. Seasons of the Year

    NSDL National Science Digital Library

    Miss Thompson

    2010-03-25

    What are the differences in the weather in each season? Students will identify the seasons of the year. Also, describing the seasonal changes in the weather. All 4 Season of the Year. Spring. Summer. Fall. Winter. ...

  19. EDITORIAL: 80 Years of Plasma 80 Years of Plasma

    NASA Astrophysics Data System (ADS)

    Franklin, R. N.; Braithwaite, N. St J.

    2009-02-01

    Irving Langmuir proposed the term 'plasma' in a paper in 1928 (Proc. Natl Acad. Sci. USA 14 627-637) to describe a 'region containing balanced charges of ions and electrons'. There does not appear to be any record of the thinking behind this proposal, so it is difficult to be definitive. One idea is that since the Greek word 'plasma' was used to describe a mouldable fluid, 'neon' lighting, with its almost limitless ability to provide colourful shapes, provided the inspiration. Another relates to the prior medical use in relation to blood with its variety of different 'corpuscles' and that the essential description of the positive column required one to recognize at least the role of the separate species of electrons, ions and gas atoms. Tonks, when questioned thirty years later, was inclined to the latter idea, but it is unlikely that we shall ever know for certain. (See postscript added December 2008.) Forty years ago most of the interest in terrestrial plasmas was centred on fusion and the prospect of thus solving the world's energy problems; the quest continues. However, since then a whole new industry has developed. It emerged in the 1970s as an imaginative way to remove the photoresist layers used in patterning semiconductor wafers. Slowly but steadily, plasma-based 'dry' processes began to displace the traditional wet chemistry processes of cleaning, etching and depositing by which the first generation of integrated circuits had been made. Plasma technology offered higher yields while accommodating the complexity of ever-shrinking feature size, driving the microelectronic revolution for almost four decades. Langmuir certainly ushered in an exciting branch of physics when he introduced the term plasma. We have included as Appendix I a condensed CV for Irving Langmuir to show, amongst other things, the early influences on his subsequent life. An interlude in Paris gave him a taste of the wider world of Europe. His subsequent schooling in the United States led to admission to Columbia University where he studied metallurgical engineering. After graduation, as was common at that time for able students, he was encouraged to go abroad for his doctoral work. He went to Göttingen, which was then one of the leading European universities in science, and studied under Nernst. Returning to the United States he obtained a post as a teaching assistant at the Stevens Institute of Technology, Hoboken, but the atmosphere proved too hierarchical and uncongenial for a scientist who was wanting to spread his wings. Fortunately the General Electric Company (GEC) recognized his potential; he was recruited in 1909, and remained associated with the GEC for the next 48 years. He quickly established his credentials as a research scientist and was soon given the freedom to pursue his interests wherever they took him, consistent with the overall strategy of the company. His appointment as an Associate Director at the GEC came in the same year that he introduced the term 'plasma'. Interestingly, while the term gained rapid acceptance in Europe, the associated word 'sheath', which Langmuir had already been using for several years, was translated into French, German and Russian and suffered from confusion. That confusion was there in Langmuir's writings because this ion-rich region sometimes was a region with barely any electrons and sometimes it contained a significant quantity of negative charge. The structure of the plasma-sheath and its elucidation had to await new mathematical techniques and the impact of computers as evidenced by papers in this volume and those quoted therein. It is clear that Langmuir inspired and benefited from collaboration with co-workers at the GEC, notably Kingdon, Taylor, Mott-Smith, Compton, Jones, Found, Tonks and Blodgett. In several ways he was ahead of his time in his understanding of gas discharges, and a particular example is what has since come to be known as the Bohm criterion. More than once in his plasma papers published in the early 1930s Langmuir stated in words what was needed for a sheath to develop

  20. Effect of Affective Temperaments Assessed by the TEMPS-A on the Relationship between Work-Related Stressors and Depressive Symptoms among Workers in Their Twenties to Forties in Japan

    PubMed Central

    Tei-Tominaga, Maki; Akiyama, Tsuyoshi; Sakai, Yoshie

    2012-01-01

    Relatively recently in Japan, immature-type depression, frequently classified in the bipolar II spectrum, has increased among workers in their twenties to forties. This study explored whether affective temperaments moderate the relationship between work-related stressors and depressive symptoms among this age group. In July 2004, self-administered questionnaires were distributed to all employees of a Japanese company. Eight hundred seventy-four employees (63%) returned the questionnaires, with 728 completed. Questionnaires included the 12-item General Health Questionnaire for assessing depressive symptoms, the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire version for assessing affective temperaments, the Effort-Reward Imbalance Questionnaire to assess work-related stressors and overcommitment, and questions regarding individual attributes and employment characteristics. Multivariate logistic regression analysis showed that affective temperaments moderated the relationship between work-related stressors and depressive symptoms. Effort (OR = 1.078), which represents job demands and/or obligations imposed on employees, and the upper tertile of overcommitment (OR = 1.589), which represents hyperadaptation to the workplace, were risk factors for depressive symptoms. Additionally, the results for cyclothymic (OR = 11.404) and anxious temperaments (OR = 1.589) suggested that depressive symptoms among this age group may be related to immature-type depression. PMID:22991659

  1. Effect of Affective Temperaments Assessed by the TEMPS-A on the Relationship between Work-Related Stressors and Depressive Symptoms among Workers in Their Twenties to Forties in Japan.

    PubMed

    Tei-Tominaga, Maki; Akiyama, Tsuyoshi; Sakai, Yoshie

    2012-01-01

    Relatively recently in Japan, immature-type depression, frequently classified in the bipolar II spectrum, has increased among workers in their twenties to forties. This study explored whether affective temperaments moderate the relationship between work-related stressors and depressive symptoms among this age group. In July 2004, self-administered questionnaires were distributed to all employees of a Japanese company. Eight hundred seventy-four employees (63%) returned the questionnaires, with 728 completed. Questionnaires included the 12-item General Health Questionnaire for assessing depressive symptoms, the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire version for assessing affective temperaments, the Effort-Reward Imbalance Questionnaire to assess work-related stressors and overcommitment, and questions regarding individual attributes and employment characteristics. Multivariate logistic regression analysis showed that affective temperaments moderated the relationship between work-related stressors and depressive symptoms. Effort (OR = 1.078), which represents job demands and/or obligations imposed on employees, and the upper tertile of overcommitment (OR = 1.589), which represents hyperadaptation to the workplace, were risk factors for depressive symptoms. Additionally, the results for cyclothymic (OR = 11.404) and anxious temperaments (OR = 1.589) suggested that depressive symptoms among this age group may be related to immature-type depression. PMID:22991659

  2. Management of isolated splenic injuries after blunt trauma: an institution's experience over 6 years.

    PubMed

    Tan, K K; Chiu, M T; Vijayan, A

    2010-12-01

    Forty-two patients with traumatic blunt splenic injuries were admitted over a six year period. Vehicular-related collisions and fall from height accounted for the injuries in 38 (90.5%) of them. Eleven (26.2%) underwent immediate surgery (7 splenectomy and 4 splenorrhaphy), while the remaining 31 patients were treated nonoperatively of which 3 underwent angio-embolisation. Twenty seven patients had either grade III or IV splenic injuries. Operative management was more likely in patients with lower haemoglobin or with more severe splenic injury. Nonoperative management can be adopted in patients with blunt isolated splenic injuries but operative management is still indispensable in certain instances. PMID:21901951

  3. Pulmonary metastases from colorectal cancer: 25 years of experience

    PubMed Central

    Irshad, Kashif; Ahmad, Faiz; Morin, Jean E.; Mulder, David S.

    2001-01-01

    Objective To examine the experience of pulmonary resections for colorectal metastases at the McGill University Health Centre. Design A chart review. Patients Forty-nine patients treated surgically between 1975 and 1998 for pulmonary metastases from colorectal cancer. Intervention Thoracotomy with pulmonary resection. Outcome measures Survival of patients with various preoperative and postoperative clinical variables. Results The perioperative death rate was 4%. Overall 5- and 10-year survival rates were 55% and 40% respectively. The mean interval between the initial colonic resection and resection of pulmonary metastases (disease-free interval) was 36 months. The 7 patients who also underwent resection of extrapulmonary metastases had a 5-year survival rate of 52%. Significant preoperative variables that carried a poor prognosis included the following: more than one pulmonary lesion, a disease-free interval of less than 2 years, and moderately or poorly differentiated colorectal cancer. The 16 patients who received chemotherapy after their thoracotomy had a 5-year survival rate of 51% compared with 54% for the 33 patients who did not receive chemotherapy. Recurrent resections of pulmonary lesions did not reduce survival. Conclusions Pulmonary resection for metastatic colorectal cancer is both effective and safe. Resectable extrapulmonary metastases and pulmonary recurrence should not preclude lung resection. Postoperative chemotherapy has no survival benefit. Preoperative variables should guide the clinician when considering surgical intervention. PMID:11407833

  4. Replicability and 40-Year Predictive Power of Childhood ARC Types

    PubMed Central

    Chapman, Benjamin P.; Goldberg, Lewis R.

    2011-01-01

    We examined three questions surrounding the Undercontrolled, Overcontrolled, and Resilient--or Asendorpf-Robins-Caspi (ARC)--personality types originally identified by Block (1971). In analyses of the teacher personality assessments of over 2,000 children in 1st through 6th grade in 1959-1967, and follow-up data on general and cardiovascular health outcomes in over 1,100 adults recontacted 40 years later, we found: (1) Bootstrapped internal replication clustering suggested that Big Five scores were best characterized by a tripartite cluster structure corresponding to the ARC types; (2) this cluster structure was fuzzy, rather than discrete, indicating that ARC constructs are best represented as gradients of similarity to three prototype Big Five profiles; and (3) ARC types and degrees of ARC prototypicality showed associations with multiple health outcomes 40 years later. ARC constructs were more parsimonious, but neither better nor more consistent predictors than the dimensional Big Five traits. Forty-year incident cases of heart disease could be correctly identified with 68% accuracy by personality information alone, a figure approaching the 12-year accuracy of a leading medical cardiovascular risk model. Findings support the theoretical validity of ARC constructs, their treatment as continua of prototypicality rather than discrete categories, and the need for further understanding the robust predictive power of childhood personality traits for mid-life health. PMID:21744975

  5. Ten year neurocognitive trajectories in first-episode psychosis

    PubMed Central

    Barder, Helene E.; Sundet, Kjetil; Rund, Bjørn R.; Evensen, Julie; Haahr, Ulrik; Ten Velden Hegelstad, Wenche; Joa, Inge; Johannessen, Jan O.; Langeveld, Johannes; Larsen, Tor K.; Melle, Ingrid; Opjordsmoen, Stein; Røssberg, Jan I.; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas; Friis, Svein

    2013-01-01

    Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory. Method: Forty-three FEP subjects (51% male, 28 ± 9 years) were followed-up neurocognitively over five assessments spanning 10 years. The test battery was divided into four neurocognitive indices; Executive Function, Verbal Learning, Motor Speed, and Verbal Fluency. The sample was grouped into those relapsing or not within the first, second and fifth year. Results: The four neurocognitive indices showed overall stability over the 10 year period. Significant relapse by index interactions were found for all indices except Executive Function. Follow-up analyses identified a larger significant decrease over time for the encoding measure within Verbal Memory for patients with psychotic relapse in the first year [F(4, 38) = 5.8, p = 0.001, ?2 = 0.40]. Conclusions: Main findings are long-term stability in neurocognitive functioning in FEP patients, with the exception of verbal memory in patients with psychotic relapse or non-remission early in the course of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that the majority of patients do not show significant change in cognitive performance during the first 10 years after being diagnosed. PMID:24109449

  6. Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age

    PubMed Central

    Kuban, Karl C. K.; Allred, Elizabeth N.; O’Shea, T. Michael; Paneth, Nigel; Pagano, Marcello; Dammann, Olaf; Leviton, Alan; Du Plessis, Adré; Westra, Sjirk J.; Miller, Cindy R.; Bassan, Haim; Krishnamoorthy, Kalpathy; Junewick, Joseph; Olomu, Nicholas; Romano, Elaine; Seibert, Joanna; Engelke, Steve; Karna, Padmani; Batton, Daniel; O’Connor, Sunila E.; Keller, Cecelia E.

    2009-01-01

    Our prospective cohort study of extremely low gestational age newborns evaluated the association of neonatal head ultrasound abnormalities with cerebral palsy at age 2 years. Cranial ultrasounds in 1053 infants were read with respect to intraventricular hemorrhage, ventriculomegaly, and echolucency, by multiple sonologists. Standardized neurological examinations classified cerebral palsy, and functional impairment was assessed. Forty-four percent with ventriculomegaly and 52% with echolucency developed cerebral palsy. Compared with no ultrasound abnormalities, children with echolucency were 24 times more likely to have quadriparesis and 29 times more likely to have hemiparesis. Children with ventriculomegaly were 17 times more likely to have quadriparesis or hemiparesis. Forty-three percent of children with cerebral palsy had normal head ultrasound. Focal white matter damage (echolucency) and diffuse damage (late ventriculomegaly) are associated with a high probability of cerebral palsy, especially quadriparesis. Nearly half the cerebral palsy identified at 2 years is not preceded by a neonatal brain ultrasound abnormality. PMID:19168819

  7. Seasons of the Year

    NSDL National Science Digital Library

    Miss Dobbin

    2010-03-24

    How does each season of the year effect what you wear? 1. Review the seasons of the year Four Seasons Review 2. Play a winter weather clothes matching game Game 3. Use the next 4 pictures to fill out your chart. Winter Spring Summer Fall ...

  8. Final Year Project Report

    SciTech Connect

    Hubsch, Tristan [Howard University

    2013-06-20

    In the last years of this eighteen-year grant project, the research efforts have focused mostly on the study of off-shell representations of supersymmetry, both on the worldline and on the world- sheet, i.e., both in supersymmetric quantum mechanics and in supersymmetric field theory in 1+1-dimensional spacetime.

  9. Gap year volunteer tourism

    Microsoft Academic Search

    Stephen Wearing; John Neil

    The valorisation of cross-cultural understanding and promotion of an ethic of global citizenship are at the forefront of the recent development and proliferation of international ‘gap year’ travel programs and policies. Governments and industry alike promote gap year travel uncritically as a guaranteed pathway to the development of inclusive ideologies associated with global citizenship. In this paper we examine how

  10. The year's new drugs.

    PubMed

    Graul, Ann I

    2004-01-01

    Inaugurated 16 years ago, this annual article provides the opportunity to present from both a historical and a research perspective those molecular entities and biologic drugs that were launched or approved in various countries for the first time during the past year. According to our records, 30 new chemical entities and biologic drugs and two diagnostic agents reached their first markets in 2003. Another six new products were approved for the first time in 2003 but were not launched before year-end. During the past year, Endocrine and Metabolic Drugs was the most active therapeutic group in terms of new launches, with six market introductions. The United States was again the most active market for new products, with a total of 20 new launches in 2003, constituting 66.6% of the total of new introductions for the year. PMID:14993934

  11. Pictures of the Year

    NSDL National Science Digital Library

    One of the oldest and most prestigious photojournalism competitions, Pictures of the Year was established 58 years ago by a University of Missouri-Columbia photojournalism professor. This year's overall winners will be announced on April 19, but in the meantime, readers can view the winning photos and those that received the Award of Excellence in the three major categories: Newspaper, Magazine, and General. These images were selected from over 32,000 entries, and they run the full gamut of subject matter and emotion. Visitors will find images that are amusing, inspiring, beautiful, and heartbreaking. Highly recommended and well worth a visit.

  12. Endoscopic excision of an eroding calcified mesh sling, 10 years after primary surgery.

    PubMed

    Wadie, Bassem S

    2009-02-01

    Management of urethral erosion typically entails two options: sling incision (in the early postoperative period) or excision of the suburethral part of the sling (urethrolysis). This paper describes a different endoscopic technique. A forty-year-old woman with a synthetic sling implanted 10 years prior presented with persistent lower urinary tract symptoms. A kidney ureter bladder X-ray showed a stone at the level of the bladder neck. Disintegration of the stone revealed eroding mesh embedded in the urethral wall. Complete resection of the mesh using an electrocautery knife was performed. Two months since the procedure, the patient has had an uneventful course. Both vaginal and urethral walls are intact, and she is capable of normal voiding with some stress incontinence. Although it is unusual, a sling eroding the urethra is a diagnosis that needs to be considered even 10 years after surgery. Endoscopic management is feasible and can be successful. PMID:18758681

  13. Double Spring Year

    E-print Network

    Hacker, Randi; Tsutsui, William; von Holten, Leslie

    2006-12-13

    Broadcast Transcript: South Korean fiancés are under pressure and the country's esteemed fortune tellers are turning up the heat. Why? Because this lunar year has two first days of spring--one last January, and another next February...

  14. 5 Year Rate Changes

    Cancer.gov

    Close Window State Cancer Profiles Quick Reference Guides ? Quick Reference Guides Index 5 Year Rate Changes Send to Printer Text description of this image. Site Home Policies Accessibility Viewing Files FOIA Contact Us U.S. Department of Health and

  15. MoonYear Applet

    NSDL National Science Digital Library

    Juergen Giesen

    This Java applet displays the phases of the Moon for calendar years 1971-2052 by month. Clicking on the day and phase gives the phase and lumination at local noon. A downloadable version is also available.

  16. Seasons of the Year

    NSDL National Science Digital Library

    2012-04-05

    What are the seasons of the year? First, watch this video about seasons. Video on seasons Next, paint a picture about the seasons. painting the seasons After you have painted a picture, play a game to identify the seasons. Game about seasons Now, go through a step by step guide about the seasons. Different seasons in a year Next, watch another video about the seasons. Video on seasons Last, fill out this chart about the seasons. In each block, ...

  17. Fiscal Year 2003

    Cancer.gov

    The Nation’s Investment in Cancer Research A Plan and Budget Proposal for Fiscal Year 2003 P re p a r ed by the Dir e c t o r National Cancer Institute National Institutes of Health A Plan and Budget Proposal for Fiscal Year 2003 . . . bringing together the resources to stimulate and support scientific discovery and its application to achieve a future when all cancers are uncommon and easily treated.

  18. Yearly Arctic Temperature Anomaly

    NSDL National Science Digital Library

    Cindy Starr

    2003-10-23

    This animation shows the yearly temperature anomaly over the Arctic region from 1981-82 through 2002-03. Years run from August 1 through July 31. Blue hues indicate cooling regions; red hues depict warming. Light regions indicate less change while darker regions indicate more. The temperature scale used ranges from -7.0 to +7.0 degrees Celsius in increments of .25 degrees. (See color bar below)

  19. Natural history of herpes zoster: late follow-up of 3.9 years (n=43) and 7.7 years (n=10).

    PubMed

    Reda, Haatem; Greene, Kaitlin; Rice, Frank L; Rowbotham, Michael C; Petersen, Karin L

    2013-10-01

    Postherpetic neuralgia (PHN) is a common complication after herpes zoster (HZ). Subjects who completed a longitudinal observational 6-month study (4 visits) of the natural history of HZ were recontacted for 2 additional follow-up visits that included pain and sensory symptom assessment, quantitative sensory testing, capsaicin response test, and 3-mm punch skin biopsies in HZ-affected, mirror-image, and control skin sites. Forty-three subjects (14 with PHN at 6 months) of the original 94 subjects in the cohort were comprehensively assessed at a median 3.9 years after HZ onset (visit 5), and 10 subjects underwent a final assessment at a median 7.7 years after HZ onset (visit 6). At 3.9 years, none of the 29 subjects who had been pain free at 6 months had a recurrence of pain. Only 2 of the 14 subjects with PHN at 6 months still had pain at 3.9 years. One subject with PHN at 6 months was free of symptoms at 3.9 years but had very mild pain at 7.7 years. Sensory function continued on a path toward normalization, but was still abnormal in many subjects, especially those who met criteria for PHN at 6 months. Even at 7.7 years, reinnervation of HZ-affected skin was not apparent. PMID:23719573

  20. Congress passes space year

    NASA Astrophysics Data System (ADS)

    The year 1992 will mark the 500th anniversary of Christopher Columbus' arrival in America and the 35th anniversary of both the International Geophysical Year and the launch of Sputnik. The U.S. Senate passed a joint resolution (S.J.Res. 177) on November 21 recommending that the President endorse an International Space Year (ISY) in 1992. A similar resolution introduced in the House of Representatives was incorporated into the conference report (House Report 99-379) accompanying the authorization bill for the National Aeronautics and Space Administration (NASA) and approved by both houses, also on November 21. As Eos went to press, the NASA authorization bill (H.R. 1714) awaited President Ronald Reagan's signature.

  1. Seasons of the Year

    NSDL National Science Digital Library

    David Stern

    This lesson demonstrates the link between the tilt of the Earth's axis to the plane of the ecliptic and seasons of the year, length of day, effectiveness of sunlight, and polar day and night. It discusses how the inclination of the Earth's rotation axis causes seasons of the year, by varying the length of the local day and the angle at which the Sun's rays arrive on the surface of the Earth, and to recognize that seasons in the southern hemisphere (at middle latitudes) occur at opposite parts of the year from seasons in the US and Europe. The student will also realize that the seasons in the middle-latitudes in US and Europe are quite different from seasons experienced near the equator and also know about the polar day, when the Sun never sets but just marches around the horizon, and the polar night, when it never rises.

  2. Emergent technologies: 25 years

    NASA Astrophysics Data System (ADS)

    Rising, Hawley K.

    2013-03-01

    This paper will talk about the technologies that have been emerging over the 25 years since the Human Vision and Electronic Imaging conference began that the conference has been a part of, and that have been a part of the conference, and will look at those technologies that are emerging today, such as social networks, haptic technologies, and still emerging imaging technologies, and what we might look at for the future.Twenty-five years is a long time, and it is not without difficulty that we remember what was emerging in the late 1980s. Yet to be developed: The first commercial digital still camera was not yet on the market, although there were hand held electronic cameras. Personal computers were not displaying standardized images, and image quality was not something that could be talked about in a standardized fashion, if only because image compression algorithms were not standardized yet for several years hence. Even further away were any standards for movie compression standards, there was no personal computer even on the horizon which could display them. What became an emergent technology and filled many sessions later, image comparison and search, was not possible, nor the current emerging technology of social networks- the world wide web was still several years away. Printer technology was still devising dithers and image size manipulations which would consume many years, as would scanning technology, and image quality for both was a major issue for dithers and Fourier noise.From these humble beginnings to the current moves that are changing computing and the meaning of both electronic devices and human interaction with them, we will see a course through the changing technology that holds some features constant for many years, while others come and go.

  3. GAP PROGRAM SIX YEAR REVIEW

    E-print Network

    Ronquist, Fredrik

    GAP PROGRAM SIX YEAR REVIEW Background for $250,000 request for FY 2011-12 budget year 10/1/2013 1 to take 10-15 years. #12;GAP HISTORY ­ 6 years in · 11 Competitions (69 proposals). 6 years · 37 Projects down by GAP committee #12;Learning As We Go · Members of GAP Committee Assigned as Year Long Mentor

  4. Annual Review of the Year

    E-print Network

    Annual Review Review of the Year 2006-2007 #12;2 | Review of the Year Review of the Year 2006-2007 #12;Review of the Year | 3 Foreword by Dr Calum MacDonald, Chair of the National Committee 4 #12;4 | Review of the Year Forewordby the Chair of the National Committee During this past year, my

  5. A rural emergency medical retrieval service: the first year

    PubMed Central

    Corfield, A R; Thomas, L; Inglis, A; Hearns, S

    2006-01-01

    Introduction We describe the first year of operation of a rural emergency medical retrieval service (EMRS), staffed by emergency medicine and anaesthetic consultants and providing air based retrieval of critically ill and injured patients from general practitioner led community hospitals in rural west Scotland. Methods Data were collected on all patients referred to the service, both those subsequently transported and those where transport by the service was not indicated, for a period of 1?year from 1 October 2004 to 30 September 2005. Data collected included information on demographics, physiology, and medical interventions. Detailed data were collected regarding advanced airway care and any complications relating to transfer. Results Forty patients were attended and advice was given on a further 21 patients. Twenty one of the 40 patients (53%) required rapid sequence intubation prior to transfer. The median Injury Severity Score (ISS) for trauma patients was 26 (range 2–59). The median Acute Physiology and Chronic Health Evaluation (APACHE) II score for all patients was 11 (range 2–37). Conclusion Our data show a high level of acuity among this patient group and a need for advanced medical intervention to ensure safe transfer. PMID:16921078

  6. Understanding Early Years Policy

    ERIC Educational Resources Information Center

    Baldock, Peter; Fitzgerald, Damien; Kay, Janet

    2005-01-01

    The book is about policy in the area of early years services and that phrase may need some clarification. For the most part, therefore, this book deals with nursery schools and classes and with services provided by full day care nurseries, pre-schools, creches, childminders, after-school clubs and holiday play schemes. This book begins with…

  7. European Music Year 1985.

    ERIC Educational Resources Information Center

    Alexanderson, Thomas; And Others

    1984-01-01

    Articles concerning music are included in this newsletter dedicated to cultural venture to be jointly carried out by the Council of Europe and the European communities. Many events will mark Music Year 1985, including concerts, dance performances, operas, publications, recordings, festivals, exhibitions, competitions, and conferences on musical…

  8. Project Year Project Team

    E-print Network

    Gray, Jeffrey J.

    and development of haptic (touch-based) human-computer interface hardware and software. A simple, single Project Title Haptic Display of Dynamic Systems Audience 30 to 40 students per year, enrolled-axis haptic interface, called the haptic paddle, will enable students to assemble, model, connect

  9. Project Year Project Team

    E-print Network

    Gray, Jeffrey J.

    Project Year 2003 Project Team Faculty: Kevin Yarema, Biomedical Engineering, Whiting School of Engineering Fellow: Lee McDaniel, Biomedical Engineering, Whiting School of Engineering Project Title Interactive Model of Biosynthetic Metabolic Pathways Audience Students enrolled in the Topics in Cell

  10. Interlochen: The Earliest Years.

    ERIC Educational Resources Information Center

    McClure, Theron

    1997-01-01

    Provides a personal reminiscence of the first two years (1928-29) of the now famous Interlochen Arts Camp. Profiles the camp's two founders, Joseph E. Maddy and Thaddeus P. Giddings. Early participants performed carpentry and landscaping duties and learned a classical music repertoire. Includes photographs of Maddy and Giddings. (MJP)

  11. Project Year Project Title

    E-print Network

    Gray, Jeffrey J.

    and Organic Chemistry courses, while others have not had biology since their freshmen year of high school traditional molecular biology courses we also aim to improve the quality of the course by integrating of Molecules and Cells in high school through classroom and lab experiences. Consequently, students who have

  12. Time [year] -normalized

    E-print Network

    Seehafer, Norbert

    Time [year] -normalized Southern Oscillation Index 1880 1900 1920 1940 1960 1980 2000 -4 -2 0 2 4 and increases during the La Niña phase. The ENSO is mostly characterized by an index called Southern Oscillation-precipi- tation (red colour intensity of varved lake sediments EP160) and Southern Oscillation Index we have found

  13. Redesigning the Senior Year

    ERIC Educational Resources Information Center

    Dreis, Janice R.; Rehage, Larry D.

    2011-01-01

    The senior year by all reason should be the capstone of an individual's time in the K-12 system. It should carry not only academic rigor, but also a spirit of unrivaled engagement if it is truly going to be an appropriate culminating experience. For many 12th graders across the country, it is far from that. How can educators create an educational…

  14. PROGRAM REPORT ACADEMIC YEAR

    E-print Network

    Meng, Ellis

    PROGRAM REPORT ACADEMIC YEAR 2008-2009 WOMEN IN SCIENCE AND ENGINEERING (WiSE) PROGRAM and Creative Work 2009 #12;1 Executive Summary The Women in Science and Engineering (WiSE) Program continues joining USC in 09-10 have already been successful. WiSE serves as an advocate for women in science

  15. The Turbulent Years.

    ERIC Educational Resources Information Center

    Scanlon, John, Ed.

    This summary of the Fourth Annual Conference on Major Transitions in the Human Life Cycle contains a preface, introductory section on adolescence and young adulthood (ages 14 through 24 years), and the following presentations, complete with discussion text: (1) "Historical Treatment of the Age Group" (John Demos); (2) "Demographic Considerations"…

  16. Eleventh Year Mathematics.

    ERIC Educational Resources Information Center

    Buchman, Aaron; Zimmerman, Robert

    This outline for Eleventh Year Mathematics in New York adheres closely to the recommendations of The Commission of Mathematics of the College Entrance Examination Board and thus presents a unified development of certain aspects of algebra, trigonometry, and analytic geometry. Its aim is both as a terminal course in mathematics and as a solid…

  17. Books of the Year

    ERIC Educational Resources Information Center

    Adults Learning, 2004

    2004-01-01

    It's that time of year again and "Adults Learning" has once more asked some of the outstanding authors who have contributed to the journal over the past 12 months to nominate their best and most valuable reads of 2004. The authors are: (1) Judith Summers; (2) Thomas Sticht; (3) Alison Wolf; (4) Tom Schuller; (5) Linden West; (6) Brian Groombridge;…

  18. Year Up Program Key Components of the Year Up Program

    E-print Network

    Wolfe, Patrick J.

    JUNE 2013 Year Up Program Key Components of the Year Up Program Year Up's mission is to close them to reach their potential through professional careers and higher education. Year Up is a nonprofit of hands-on skill development and workplace apprenticeship opportunities. Year Up Benefits to FAS

  19. Longitudinal posturography and rotational testing in children 3-9 years of age: Normative data

    PubMed Central

    Casselbrant, Margaretha L.; Mandel, Ellen M.; Sparto, Patrick J; Perera, Subashan; Redfern, Mark S.; Fall, Patricia A.; Furman, Joseph M.

    2010-01-01

    Objective To obtain normative longitudinal vestibulo-ocular and balance test data in children from ages 3 to 9 with normal middle-ear status. Study Design Prospective, longitudinal cohort Setting Tertiary care pediatric hospital Subjects and Methods Three-year-old children were entered and tested yearly. Subjects underwent earth vertical axis rotation testing using sinusoidal and constant velocity stimuli and performed the Sensory Organization Test. Results One hundred forty-eight children were entered and usable data were collected on 127 children. A linear increase in the vestibulo-ocular reflex gain as children aged was found, without a change in the phase of the response. An age-related linear increase in Equilibrium Scores, indicating reduced postural sway, was also observed. Conclusion These normative data can be used in the evaluation of dizziness and balance disorders in children. PMID:20416461

  20. Projects of the year

    Microsoft Academic Search

    2007-01-01

    The Peabody Hotel, Orlando, Florida was the site of Power Engineering magazine's 2006 Projects of the Year Awards Banquet, which kicked-off the Power-Gen International conference and exhibition. The Best Coal-fired Project was awarded to Tri-State Generation and Transmission Association Inc., owner of Springenville Unit 3. This is a 400 MW pulverized coal plant in Springeville, AZ, sited with two existing

  1. Publications through Twentifive Years

    E-print Network

    Sinha, Nirmal C.; Rechung, Jampal Kunzang

    1983-01-01

    PUBLICATIONS THROUGH TWENTIFIVE YEARS - JKR : NCS A quarter of a century is a fragment in the history of letters. In . modern period, particularly in the current century, learning finds speedy expression in wide and varied forms. Number... . In 1976 we decioed to produce important Tibetan works' diirect from' the original prints. The practice of' transfer into Calligraph Copy, ·and thereafter into print" on palm, leaUormat" is not free from errOrs' and: omissions in copying process...

  2. Fifty years later.

    PubMed

    Mangan, Terry L; Benedetti, Kathleen A; Starzl, Thomas E

    2013-01-01

    That concludes my remarks. If I have not made my purpose clear, let me summarize simply. I, like all others gathered here, have come to pay homage to Paul Terasaki, a man who bent in the winds of his time but never broke. Over the last 50 years, I have worked with many people. No collaboration has been dearer than that with Paul (Fig. 7). PMID:25095497

  3. NUCLEAR ENGINEERING Four Year Plan

    E-print Network

    Tullos, Desiree

    15 Term 16 CUM 15 CUM 30 CUM 46 FALL Year 2 Credits WINTER Year 2 Credits SPRING Year 3 Credits ENGR @ 4 MTH 306 4 Biological Science 4 Term 15 Term 15 Term 14 CUM 61 CUM 76 CUM 90 FALL Year 3 Credits 14 Term 16 CUM 104 CUM 118 CUM 134 FALL Year 4 Credits WINTER Year 4 Credits SPRING Year 4 Credits NE

  4. Five Year Flashlight

    NASA Technical Reports Server (NTRS)

    1978-01-01

    An ultra-reliable flashlight, initially developed for rescue signaling and utility use by NASA astronauts and military aircrews, has attracted a broad commercial market. Called the Five Year Light, it has a shelf life at least that long because there is no power drain on the batteries when the flashlight is not in use. The NASA version of the light was developed under contract with Langley Research Center by ACR Electronics, Inc., now known as the Chromalloy Electronics Division of Chromalloy American Corporation, Hollywood, Florida. NASA wanted a light that had long shelf life and assured reliability in case it was needed in an emergency. Reliability was designed into the flashlight by means of a unique switch. Instead of the customary thumb-button, the Five Year Light is turned on by rotating its collar to make contact with the battery terminal; the turning motion wipes away any corrosion that might be present and makes contact virtually certain. The Five Year Light available commercially is a repackaged version of the NASA light. It is sold for car, home, industrial, police, firefighting, recreational and a variety of other uses, and sales have topped two million units.

  5. A vertical micro-scale light guiding silicon dioxide tube array for optical neurostimulator

    Microsoft Academic Search

    M. Sakata; A. Goryu; A. Ikedo; T. Harimoto; M. Ishida; T. Kawano

    2011-01-01

    In this paper, we present out-of-plane micro-scale diameter light guiding silicon dioxide tube arrays for use in optical stimulation of neurons. An optical propagation through the dioxide tube was calculated by using finite-difference time-domain (FDTD) simulation. Based on the calculated result, we designed and fabricated 3-µm-inner diameter 24-µm-height silicon dioxide tube arrays with the wall thickness of 0.5 µm, using

  6. Addressable Floating Light Activated Micro-Electrical Stimulators for Wireless Neurostimulation

    E-print Network

    Member, IEEE Abstract-- Stimulation of the central nervous system can be useful for treating neurological. INTRODUCTION Electrical stimulation of the central nervous system (CNS) has been used as a treatment larger than 2mm. These RF stimulators are attractive for use in the peripheral nervous system

  7. A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation

    PubMed Central

    Balan, Puiu F.; Gerits, Annelies; Vanduffel, Wim

    2014-01-01

    The exponential growth in publications represents a major challenge for researchers. Many scientific domains, including neuroscience, are not yet fully engaged in exploiting large bodies of publications. In this paper, we promote the idea to partially automate the processing of scientific documents, specifically using text mining (TM), to efficiently review big corpora of publications. The “cognitive advantage” given by TM is mainly related to the automatic extraction of relevant trends from corpora of literature, otherwise impossible to analyze in short periods of time. Specifically, the benefits of TM are increased speed, quality and reproducibility of text processing, boosted by rapid updates of the results. First, we selected a set of TM-tools that allow user-friendly approaches of the scientific literature, and which could serve as a guide for researchers willing to incorporate TM in their work. Second, we used these TM-tools to obtain basic insights into the relevant literature on cognitive rehabilitation (CR) and cognitive enhancement (CE) using transcranial magnetic stimulation (TMS). TM readily extracted the diversity of TMS applications in CR and CE from vast corpora of publications, automatically retrieving trends already described in published reviews. TMS emerged as one of the important non-invasive tools that can both improve cognitive and motor functions in numerous neurological diseases and induce modulations/enhancements of many fundamental brain functions. TM also revealed trends in big corpora of publications by extracting occurrence frequency and relationships of particular subtopics. Moreover, we showed that CR and CE share research topics, both aiming to increase the brain's capacity to process information, thus supporting their integration in a larger perspective. Methodologically, despite limitations of a simple user-friendly approach, TM served well the reviewing process. PMID:25309356

  8. Translumbar and Transsacral Magnetic Neuro-Stimulation for the Assessment of Neuropathy in Fecal Incontinence

    PubMed Central

    Rao, Satish SC; Coss-Adame, Enrique; Tantiphlachiva, Kasaya; Attaluri, Ashok; Remes-Troche, Jose

    2014-01-01

    Background Neurological dysfunction causes fecal incontinence, but current techniques for its assessment are limited and controversial. Objective To investigate spino-rectal and spino-anal motor evoked potentials simultaneously using lumbar and sacral magnetic stimulation in fecal incontinence and healthy subjects, and to compare motor evoked potentials and pudendal nerve terminal motor latency in fecal incontinence subjects. Design Prospective observational study. Settings Two Tertiary Care Centers. Patients Adult fecal incontinence and healthy subjects. Interventions Translumbar and transsacral magnetic stimulations performed bilaterally by applying a magnetic coil to the lumbar and sacral regions in 50 fecal incontinence (? 1 episode/week) and 20 healthy subjects. Both motor evoked potentials and pudendal nerve terminal motor latency were assessed in 30 fecal incontinence patients. Stimulation-induced motor evoked potentials were recorded simultaneously from rectum and anus with two pairs of bipolar ring electrodes. Main Outcome Measurements Latency and amplitude of motor evoked potentials after lumbosacral magnetic stimulation and agreement with pudendal nerve terminal motor latency. Results When compared to controls, one or more lumbo-anal, lumbo-rectal, sacro-anal, or sacro-rectal motor evoked potentials were significantly prolonged (p<0.01) and were abnormal in 44/50 (88%) fecal incontinence subjects. Positive agreement between abnormal motor evoked potentials and pudendal nerve terminal motor latency was 63% whereas negative agreement was 13%. motor evoked potentials were abnormal in more (p <0.05) fecal incontinence patients than pudendal nerve terminal motor latency, 26/30 (87%) versus 19/30 (63%) respectively, and in 24% of patients with normal pudendal nerve terminal motor latency. No adverse events. Limitations Anal electromyography was not performed. Conclusions Translumbar and transsacral magnetic stimulation–induced motor evoked potentials provide objective evidence for rectal or anal neuropathy in fecal incontinence patients and could be useful. Test was superior to pudendal nerve terminal motor latency and appears to be safe and well tolerated. PMID:24819106

  9. Clinical utility of implantable neurostimulation devices in the treatment of chronic migraine

    PubMed Central

    Freeman, John A; Trentman, Terrance L

    2013-01-01

    Chronic migraine is a disabling disorder that is costly to individuals and society. Occipital nerve stimulation has been used to treat refractory cases of primary headache disorders including drug-resistant chronic cluster headaches and chronic migraine. The Food and Drug Administration (FDA) off-labeled application of equipment used for peripheral nerve (occipital) stimulation is borrowed from FDA-labeled spinal cord stimulation. Manufacturer-sponsored randomized trials include a feasibility study (ONSTIM-Medtronic) and a safety and efficacy study (St Jude). A non-industry sponsored prospective, randomized crossover study by Serra and Marchiotretto suggests improved quality of life and a significant reduction in medication use. Though preliminary studies suggest occipital nerve stimulation is safe and efficacious in treating chronic migraine headache, complication rates, including lead migration, lead fracture, and surgical site infections remain high. Further studies are needed to demonstrate long-term outcomes, while improved surgical techniques and site-specific equipment are needed to minimize complications. PMID:24348076

  10. Implementation of a biocircuit implants for neurotransmitter release during neuro-stimulation.

    PubMed

    Ly, Suw Young; Choi, Dal woong

    2013-08-01

    Neurotransmitter assay of epinephrine (EP) was sought using a modified carbon nanotube paste electrode (PE). Using optimum conditions, cyclic voltammetry (CV) and the square wave (SW) stripping voltammetric working ranges were attained to 10-100 mgL(-1) (CV) and 20-140 ngL(-1) (SW). The relative standard deviation of 0.0549 (n=15) was obtained at 20.0 mgL(-1) EP constant. Here, the analytical detection limit (S/N) was reached with 4.60 ngL(-1) (2.5×10(-11) molL(-1)) EP. The hand-made electrode was implanted into the in-vivo brain core of the animals and was used in chronoamperometric neurodetection. The results obtained are applicable in neurosensing, physiological control, and other neuroscience fields. PMID:23782097

  11. Applications of Neurostimulation for Urinary Storage and Voiding Dysfunction in Neurological Patients

    Microsoft Academic Search

    F. S. Van Rey; J. P. F. A. Heesakkers

    2008-01-01

    The application of various forms of electrical stimulation is considered a therapeutic option to manage different types of lower urinary tract dysfunction. However, even though lower urinary tract dysfunction is common in patients with neurological disease, apart from patients with spinal cord injury, electrostimulation is still not widely applied in a neurological patient population. Urologists frequently encounter patients with neurogenic

  12. Two-Year Follow-up of the Collision Auto Repair Safety Study (CARSS).

    PubMed

    Bejan, Anca; Parker, David L; Brosseau, Lisa M; Xi, Min; Skan, Maryellen

    2015-06-01

    This paper presents an evaluation of the sustainability of health and safety improvements in small auto collision shops 1 year after the implementation of a year-long targeted intervention. During the first year (active phase), owners received quarterly phone calls, written reminders, safety newsletters, and access to online services and in-person assistance with creating safety programs and respirator fit testing. During the second year (passive phase), owners received up to three postcard reminders regarding the availability of free health and safety resources. Forty-five shops received an evaluation at baseline and at the end of the first year (Y1). Of these, 33 were evaluated at the end of the second year (Y2), using the same 92-item assessment tool. At Y1, investigators found that between 70 and 81% of the evaluated items were adequate in each business (mean = 73% items, SD = 11%). At Y2, between 63 and 89% of items were deemed adequate (mean = 73% items, SD = 9.5%). Three safety areas demonstrated statistically significant (P < 0.05) changes: compressed gasses (8% improvement), personal protective equipment (7% improvement), and respiratory protection (6% decline). The number of postcard reminders sent to each business did not affect the degree to which shops maintained safety improvements made during the first year of the intervention. However, businesses that received more postcards were more likely to request assistance services than those receiving fewer. PMID:25539646

  13. 500 years after Columbus.

    PubMed

    Imbach, A

    1992-01-01

    The astonishing range of plants and animals of Central America's 7 countries (Guatemala, Belize, Honduras, El Salvador, Nicaragua, Costa Rica and Panama) is disappearing, as 60% of its forests have been cut for lumber and firewood as well as for cotton, cattle, or subsistence crops. Up to 5 million Mayans lived sustainably for thousands of years in an area now being destroyed by a few hundred thousand inhabitants. The Spanish colonization that started 500 years ago was concentrated in Panama, Nicaragua, and Guatemala. The majority of the English-speaking country of Belize are descended from the black slave population whose culture spread down the coast to Central America. Panama's service economy is based on the Panama Canal and trade and finance. Costa Rica benefits from a tourist industry based on its natural beauty, however, it also has the highest rate of deforestation and its fast population growth could jeopardize earlier social and economic progress. In El Salvador and Guatemala long periods of civil conflict have taken their toll on the economy and the environment. El Salvador has a mountainous territory and limited natural resources and industrialization, while the best land is in the hands of a few families. Honduras and Nicaragua retain the highest proportion of forest cover of the countries in the region, despite Nicaragua's years of tyranny, then revolution and the Contra war, and Honduras's own turmoils. Belize has achieved some stability, and is now strengthening its Central American links. Its coral reefs and coastal areas offer potential for sustainable development through fishing and tourism. Central American countries face the challenges of their fragile environments and major social problems. PMID:12317700

  14. TRMM 3-Year Anniversary

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Ever wonder about the rain? Beyond the practicality of needing an umbrella, climate researchers have wondered about the science of rainfall for a long time. But it's only in the past few years that they've begun to roll back some of its secrets. One of their tools for doing so is a powerful satellite called the Tropical Rainfall Measuring Mission, or TRMM. Now, after three years of continual operation, project scientists have released dramatic new maps of rainfall patterns gathered across a wide band of the Earth. And with measurements from one of the satellite's advanced sensors, meteorologists are now able to calibrate ground-based rain monitoring systems with greater precision than ever before. A complete accounting of the world's total rainfall has long been a major goal of climate researchers. Rain acts as the atmosphere's fundamental engine for heat exchange; every time a raindrop falls, the atmosphere gets churned up and latent heat flows back into the total climate system. Considering that rainfall is the primary driving force of heat in the atmosphere, and that two thirds of all rain falls in the tropics, these measurements are significant for our understanding of overall climate. The above image shows a one month average of rainfall measurements taken by the TRMM's unique precipitation radar during January of 1998. Areas of low rainfall are colored light blue, while regions with heavy rainfal are colored orange and red. TRMM began collecting data in December of 1997, and continues today. For more information about TRMM's 3-year anniversary, read Maps of Falling Water To learn more about the TRMM mission or order TRMM data, see the TRMM Home Page. Image courtesy TRMM Science team and the NASA GSFC Scientific Visualization Studio.

  15. Seasons of the Year

    NSDL National Science Digital Library

    Ms. Larrimore

    2012-04-11

    You are going to watch some videos of the seasons of the year.Use your worksheet to help you remember the types of weather and the clothes we wear during the different seasons. What is different about each season? Seasons Chart 1. This is what you will click on to watch the video on winter. Winter Video 2. In the spring video make sure you notice the changes in weather Spring Video 3. Now watch the summer video Summer Video 4.This is what you will click on to watch the video on fall. Fall Video 5. Click here to watch a video ...

  16. Helsinki 50 years on.

    PubMed

    Petrini, C

    2014-01-01

    Ever since its adoption the Declaration of Helsinki has been universally recognised as a key landmark in the ethics of medical research involving human subjects. Over fifty years it has been revised seven times and supplemented twice with explanatory notes. The debate surrounding its contents and organisation continues unabated and becomes particularly lively every time the text is reviewed. One of the most controversial issues is recourse to the placebo: the conditions laid down for its use are held by many to offer insufficient guarantees for the protection of those receiving it. PMID:25203329

  17. Publications through Twentyfive Years

    E-print Network

    Sinha, Nirmal C.; Rechung, Jampal Kunzang

    1984-01-01

    PUBLICA TIONS THROUGH TWENTYFIVE YEARS - JKR: NCS A quarter of a century is. a fragment in the history of letters. In modern period, particularly in the current century, learning finds speedy expression in wide and varied forms. Numb... , on palm leaf format, is not free from errors and omissions in copying proc('Ss. For authentication of the text a direct photo-mechanic reproduction of the original is thus indispensable, ev<:n though this may be costlier. So in 1976 a pro­ gramme...

  18. Developmental milestones record - 5 years

    MedlinePLUS

    Normal childhood growth milestones - 5 years; Childhood growth milestones - 5 years; Growth milestones for children - 5 years ... both the time and content of television and computer viewing Visiting local areas of interest Encouraging the ...

  19. International Heliophysical Year

    NASA Technical Reports Server (NTRS)

    Davila, Joseph, M.

    2005-01-01

    The International Heliophysical Year (IHY), an international program of scientific collaboration to understand the external drivers of planetary environments, will be conducted in 2007. This will be a major international event of great interest to the member States. The M Y will involve the deployment of new instrumentation, new observations from the ground and in space, and an education component. The IHY 2007 will coincide with the fiftieth anniversary of the International Geophysical Year (IGY) in 1957. The IGY was organized to study global phenomena of the Earth and Geospace involving about 60,000 scientists from 66 nations, working at thousands of stations, around the world to obtain simultaneous, global observations from the ground and space. Building on results obtained during IGY 1957, the IHY will expand to the study of universal processes in the solar system that affect the interplanetary and terrestrial environments. The study of energetic events in the solar system will pave the way for safe human space travel to the Moon and planets in the future, and it will serve to inspire the next generation of space physicists.

  20. Broadcast Education Curricula in 2-Year and 4-Year Colleges.

    ERIC Educational Resources Information Center

    Koch, Erin; Kang, Jong G.; Allen, David S.

    1999-01-01

    Compares broadcasting curricula of two-year and four-year colleges. Finds that most broadcast programs implement a blend of practical and theoretical courses, and that students at two-year and four-year schools are subjected to comparable course work and internship/practicum experience. Suggests that many students are not receiving enough…

  1. Electroencephalography 60 years later.

    PubMed

    Kugler, J

    1991-03-01

    The birthday of Electroencephalography (EEG) is dated back to the 22nd of April 1929. On this date Hans Berger submitted the first of his 14 contributions "Uber das Elektrenkephalogramm des Menschen" to the "Archiv für Psychiatrie und Nervenkrankheiten" for publication. Therefore in 1989 Electroencephalography was 60 years of age. In spite of controversy over its usefulness during this period, Electroencephalography substantially contributed to progress in medicine. Today is the beginning of its Renaissance due to a dramatic diversification of Clinical Electroencephalography into applied neurophysiological specialties. Progress became possible by the introduction of new techniques. However it will become obvious that new instrumentations cannot replace intelligence and human understanding. The dispute of importance and nonsense, use and misuse of Electroencephalography is without doubt useful and stimulates new orientations. PMID:2047558

  2. All Year Long

    NSDL National Science Digital Library

    In this activity, each student will keep a science journal during each of the four seasons. Students will record observations of the general outdoor environment they visit and then will make observations of one specific item from the habitat in each season. At the end of the school year, students will compare their seasonal drawings and share their results with the class. This is the 1st of 3 sets of learning activities that are part of a unit on seasons that are companion activities to the Elementary GLOBE children's book, "Mystery of the Missing Hummingbirds." Includes a teacher implementation guide. GLOBE (Global Learning and Observation to Benefit the Environment) is a worldwide, hands-on, K-12 school-based science education program.

  3. Sustained linear growth and preserved renal function in 10-year survivors of pediatric liver transplantation.

    PubMed

    Lee, Sanghoon; Kim, Jong-Man; Choi, Gyu-Seong; Kwon, Choon Hyuck D; Choe, Yon-Ho; Joh, Jae-Won; Lee, Suk-Koo

    2015-07-01

    The aim of this study was to characterize the clinical outcomes of children and adolescents who achieved survival of more than 10 years following liver transplantation (LT) in a single center in Korea. From June 1996 to October 2003, 57 pediatric LTs were performed. The medical records of 44 patients who had survived more than 10 years were reviewed retrospectively. Median age of patients at LT was 0.8 years. Forty-one patients received living donor LT, and three patients received deceased donor LT. Biliary atresia was the most common indication (65.9%). Thirty-five patients were on tacrolimus monotherapy at 10 years post-LT with a mean trough level of 2.73 ng/ml, and five patients were maintaining stable graft function without any immunosuppression. There were no patients receiving antihypertensive medication and one case of diabetes mellitus. Renal dysfunction was seen in two patients (4.5%), while none required renal replacement therapy. Mean height z-score prior to LT was -1.35 and at 10 years post-transplant was 0.05. Good linear growth was sustained in this cohort throughout the 10 years, approaching the 50th percentile. Also, there were remarkably low incidences of renal dysfunction and patients requiring medications for glycemic or hypertensive control, all hallmarks of continued use of immunosuppressive agents. PMID:25711921

  4. PERSISTENCE RATES --FRESHMAN COHORT BY ORIGINAL TUITION CLASSIFICATION FALL COHORT YEAR 2 YEAR 3 YEAR 4 YEAR 5

    E-print Network

    2009 SOPHOMORE TO JUNIOR PERSISTENCE RATES TOTAL RES NON #12;4 GRADUATION RATES -- FRESHMAN COHORT FALL GRADUATION RATES -- FRESHMAN COHORT YEAR 4 YEAR 5 YEAR 6 TOTAL #12;5 GRADUATION RATES BY GENDER -- FRESHMAN COHORT GRADUATION RATES -- FRESHMAN COHORT MALES FALL END OF END OF END OF GRADRATE TERM COHORT YEAR 4

  5. The International Heliophysical Year

    NASA Technical Reports Server (NTRS)

    Davila, Joseph M.; Gopalswamy, Nat; Thompson, Barbara

    2008-01-01

    It is now widely recognized that evolution in the solar system proceeds through a set of Universal Processes, i.e. reconnection, particle acceleration, plasma wave generation and propagation, etc. By studying these Universal Processes together, in diverse environments, and in a comparative way, new scientific insights will be gained. This is perhaps best understood by citing a few examples: (I) Shocks are observed in situ in the interplanetary medium, shocks are believed to play a role in the acceleration of particles in the solar corona, and standing bow shocks and termination shocks separate the major regions in the heliosphere. Shock formation, and particle acceleration are universal processes. (2) Aurorae are observed on Earth, Saturn, and Jupiter, and Jovian auroral "footprints" have been observed on 10, Ganymede and Europa. The formation of aurorae is observed to be the universal response of a magnetized body in the solar wind. The International Heliophysical Year (IHY) specifically highlights the cross-disciplinary study of universal physical processes in the solar system, observed in a variety of settings. The study of these processes will provide new insights that will lead to a better understanding of the universal processes in the solar system that affect the interplanetary and planetary environments, and pave the way for safe human space travel to the Moon and planets in the future, and it will serve to inspire the next generation of space physicists.

  6. [Sixty years of autism].

    PubMed

    van Berckelaer-Onnes, I A

    2004-05-22

    The concept of autism has been broadened the last few years from 'early infantile autism' to 'an autistic spectrum'. Autism and related contact disorders are grouped together under 'pervasive developmental disorders' or 'autistic spectrum disorders'. The autistic disorder, Asperger's syndrome, pervasive developmental disorder not otherwise specified (PDD-NOS), Rett's disorder and the childhood disintegrative disorder all belong to this group. People with an autistic spectrum disorder have severe difficulties in the integration of perceived stimuli into a meaningful entity. More than two-thirds of the people with the autistic disorder (classical autism) are also mentally retarded. Although autism can still only be diagnosed at the behavioural level, there is considerable consensus regarding an underlying organic aetiology. Autism is clearly a multifactorial condition. Autism cannot be cured, but adequate intervention can significantly improve the quality of life of people with this disorder. Diagnosis and intervention are highly interrelated. In the intervention, a distinction is made between family-oriented and child-oriented strategies. Augmentative communication plays a key role in the treatment. People with autism need a lot of structure, clarity and predictability, also when they have become adults. PMID:15185436

  7. WMAP First Year Results

    E-print Network

    E. L. Wright

    2003-06-05

    The Wilkinson Microwave Anisotropy Probe (WMAP) science team has released results from the first year of operation at the Earth-Sun L2 Lagrange point. The maps are consistent with previous observations but have much better sensitivity and angular resolution than the COBE DMR maps, and much better calibration accuracy and sky coverage than ground-based and balloon-borne experiments. The angular power spectra from these ground-based and balloon-borne experiments are consistent within their systematic and statistical uncertainties with the WMAP results. WMAP detected the large angular-scale correlation between the temperature and polarization anisotropies of the CMB caused by electron scattering since the Universe became reionized after the "Dark Ages", giving a value for the electron scattering optical depth of 0.17+/-0.04. The simplest Lambda-CDM model with n=1 and Omega_tot=1 provides an adequate fit to the WMAP data and gives parameters which are consistent with determinations of the Hubble constant and observations of the accelerating Universe using supernovae. The time-ordered data, maps, and power spectra from WMAP can be found at http://lambda.gsfc.nasa.gov along with 13 papers by the WMAP science team describing the results in detail.

  8. Thalidomide: 40 years on.

    PubMed

    Diggle, G E

    2001-11-01

    Thalidomide was marketed in the late-1950s as a sedative and tranquilliser of exceptionally low general toxicity, but in 1961 it was implicated separately by Lenz and MacBride as the cause of the epidemic of congenital malformations that had been puzzling the world for some years. It is a very potent teratogen in humans, but in few other mammalian species; damage to the embryo is produced at specific stages of gestation, but the mechanism of embryopathic action is still not understood. Following the withdrawal of the drug worldwide, it was consigned to the history of medical tragedies. In 1965, however, Sheskin discovered that it was effective in treating erythema nodosum leprosum, a distressing complication of leprosy. As the drug is neither an antibiotic nor an analgesic, its action was assumed to be immunosuppressive. In Brazil the drug was used widely with few regulatory controls, since when more than 100 cases of congenital malformation have appeared. Sheskin's discovery led to the experimental use of thalidomide in many other indications thought to possess some immunological component. In some cases, e.g. Behçet's syndrome, graft-versus-host disease and aphthous ulceration in HIV-positive patients, the drug has been shown to possess some efficacy. And there is some evidence that it inhibits the replication of one of the immunodeficiency viruses. The AIDS community in the US has exerted much pressure on the FDA to allow the drug on to the market, although the use of a potent immunosuppressive drug of unknown mechanism in an immunodeficiency condition raises further questions. Thalidomide is not always beneficial; its use is associated with an increased mortality in epidermal necrolysis. In 1991, D'Amato confirmed it possessed antiangiogenic properties and this led to further trials in malignant conditions. Results were mixed, but those in multiple myeloma gave some grounds for optimism. In 1998, the FDA announced its extraordinary decision to grant marketing approval for thalidomide. PMID:11770361

  9. 50 Year Mark Guidelines Primary 50 Year Mark

    E-print Network

    Rose, Michael R.

    ciencies of all materials executed with the UCI brand name. Adherence to the UCI 50 Year Mark and Color Primary and Secondary master brand logo. For all materials (digital and print) where the UCI 50 Year Mark will appear with the UCI Primary and Secondary master brand logo. Note: The Secondary UCI 50 Year Mark should

  10. A Modified School Year: Perspectives from the Early Years

    ERIC Educational Resources Information Center

    Winter, Eileen C.

    2005-01-01

    A balanced or modified school year is a rearrangement of the traditional school calendar to provide more continuous learning throughout the school year. Students receive the same amount of instructional time as those on the traditional calendar but in-school time is more evenly balanced with out-of-school time throughout the year. It has been the…

  11. Nepal Migration Year Book 2011 Migration Year Book

    E-print Network

    Richner, Heinz

    Nepal Migration Year Book 2011 1 #12;Nepal Migration Year Book 2011 NIDS NCCR North-South #12;Book Nepal Migration Year Book 2011 Publishers Nepal Institute of Development Studies (NIDS) G.P.O. Box: 7647, Kathmandu, Nepal Email: nids@mail.com.np Web: www.nids.org.np National Centre of Competence in Research

  12. 2004 YEAR IN TORNADOES: WHAT A YEAR IT WAS!

    E-print Network

    2004 YEAR IN TORNADOES: WHAT A YEAR IT WAS! Daniel McCarthy and Joseph Schaefer NOAA/NWS Storm Prediction Center, Norman, OK 1. INTRODUCTION 2004 will be known as the biggest tornado year since recordkeeping began in 1950. The sheer numbers of tornadoes were unprecedented: 1,819. This number eclipsed

  13. Second-generation proximally coated titanium femoral component: minimum 7-year results.

    PubMed

    Lachiewicz, Paul F; Soileau, Elizabeth S; Bryant, Paul

    2007-12-01

    It is unclear whether resurfacing or fully porous-coated or proximally coated stems are the best femoral components for young patients. First-generation proximally coated titanium fiber-metal femoral components had a high rate of failure. We prospectively followed 56 patients (70 hips) whom we believed were at high risk for loosening of a cemented femoral component; all patients were implanted with one second-generation proximally coated titanium femoral component. Ten patients (11 hips) died and three patients (four hips) were lost to minimum followup. Three models of titanium fiber-metal acetabular component were implanted with screws. Patients were clinically evaluated using the Harris hip score. We used standardized radiographs to assess fixation status and osteolysis. Forty-four patients (55 hips) with a mean age of 45 years were followed for a minimum of 7 years (mean, 10.5 years; range, 7-15 years). No femoral component had been revised for any reason. Bone ingrowth (spot welding) was seen in 41 hips (75%) and proximal femoral osteolysis in only four hips. Reoperations for polyethylene wear were performed in seven patients (12.7%) and two patients had liner exchange for recurrent dislocation. Even with an articulating surface with considerable polyethylene wear debris, these second-generation proximally coated titanium fiber-metal femoral components had a survival rate of 100% at a mean 10.5-year followup. PMID:17621229

  14. 20 Years of RECONS

    NASA Astrophysics Data System (ADS)

    Henry, Todd J.; RECONS

    2014-01-01

    RECONS (REsearch Consortium On Nearby Stars, www.recons.org) turns 20 in 2014, so we take this opportunity to review some of the highlights of the RECONS effort over the past two decades. Through comprehensive searches for new nearby stars, as well as characterization of the stars and exploration of their environments, the RECONS team has made significant contributions to our understanding of the solar neighborhood, and of our own place in the Universe. Here we highlight results detailed in more than 30 papers in The Solar Neighborhood series published in The Astronomical Journal, including: (1) a census indicating that at least 75% of all stars are red dwarfs, which have more real estate available for habitable planets than any other type of star, (2) more than 300 new stellar systems with accurate trigonometric parallaxes placing them within 25 pc, including 12 of the nearest 100 systems, (3) thousands of additional nearby star candidates identified through traditional proper motion searches and novel photometric searches for stars exhibiting minimal proper motions, (4) increases of more than 20% in the nearest white dwarf and cool subdwarf populations, (5) discovery of the nearest star, AP Col, younger than 100 million years, (6) knowledge that more than half of stellar systems contain only one star, dominated by the red dwarf multiplicity rate of only about 30%, (7) definition of the smallest main sequence star, with a radius only 9% that of the Sun (smaller than Jupiter) and a temperature of 2100K, and (8) a revelation that the smallest stars are rarely orbited by giant planets, including the elimination of planets down to half a Jupiter mass orbiting Proxima Centauri. As RECONS enters its third decade, we continue our reconnaissance of the solar neighborhood via a comprehensive survey to understand the nature of star formation by determining accurate luminosity and mass functions for the nearest stars. In addition, we are taking an inventory of nearby planets, including an astrometric search of several hundred of the nearest red dwarfs for planetary systems. This effort is supported by the NSF through grants AST-0908402 and AST-1109445, and via observations made possible by the SMARTS Consortium.

  15. Five years of sentinel node biopsy for melanoma: the St George's Melanoma Unit experience.

    PubMed

    Topping, Adam; Dewar, Donald; Rose, Victoria; Cavale, Naveen; Allen, Rosemary; Cook, Martin; Powell, Barry

    2004-03-01

    Sentinel node biopsy has become an integral part of the management of malignant melanoma. Here, the authors describe the technique that is used at the St George's Hospital Melanoma Unit. Results obtained over the past 5 years on a cohort of patients are presented. Three hundred and forty seven patients were entered in the study. Population demographics were analysed for both the primary melanoma and for sentinel node positive status. Histological features of the primary, particularly regression were noted and, in addition to metastatic disease, the presence of capsular naevus cells within the node also recorded. Complications associated with the procedure have been presented along with the specificity and sensitivity of the technique. The relative influence of both Breslow thickness and sentinel node positivity were analysed statistically and Kaplan-Meier survival curves produced for the cohort as a whole. This confirmed the accuracy of sentinel node biopsy and its role as a prognostic indicator. PMID:15037163

  16. Ground-penetrating radar investigations conducted in the 100 areas, Hanford Site: Fiscal Year 1992

    SciTech Connect

    Bergstrom, K.A.

    1994-10-01

    During Fiscal Year 1992, the Geophysics Group conducted forty- five Ground-Penetrating Radar (GPR) surveys in the 100 Areas (Figure 1) - Objectives for the investigations varied, from locating cribs, trenches and septic systems to helping site boreholes. The results of each investigation were delivered to clients in the form of a map that summarized the interpretation of a given site. No formal reports were prepared. The purpose of this document is to show where and why each of the surveys was conducted. The data and interpretation of each survey are available by contacting the Westinghouse Hanford Company, Geophysics Group. A map showing the location and basic parameters of each survey can be found in the Appendices of this report.

  17. Trends in joint arthroplasty litigation over five years: the British experience

    PubMed Central

    Bhutta, MA; Arshad, MS; Hassan, S; Henderson, JJ

    2011-01-01

    INTRODUCTION Increasing numbers of joint arthroplasty are performed in Britain. While associated complications are well documented, it is not known which of those initiate malpractice claims. METHOD A five-year period was assessed for trends to highlight areas for further improvement in patient information and surgical management. RESULTS The National Health Service paid out almost £14 million for 598 claims. Forty per cent of this was for legal costs. The number of claims increased over time while the rate of successful claims decreased. CONCLUSIONS A failure to consent adequately and to adhere to policies and standard practice can result in a successful malpractice claim. Protecting patients intrao-peratively and maintaining high technical expertise while implementing policies and obtaining informed consent decreases the litigation burden. PMID:21929916

  18. Pharmaceuticals: pharmaceutical cost controls--2005. End of Year Issue Brief.

    PubMed

    Seay, Melicia; Varma, Priya

    2005-12-31

    The enactment of the Omnibus Budget Reconciliation Act of 1990 (OBRA '90) gave states the option of offering pharmaceutical benefits within their Medicaid programs. But the law placed restrictions on states' flexibility to control what prescriptions they would cover and required the states to reimburse outpatient prescription drugs from manufacturers that signed rebate agreements with the U.S. Department of Health and Human Services. Forty-nine states--Arizona is excluded, based on its program structure--and the District of Columbia currently offer prescription drug coverage under the Medicaid Drug Rebate Program. During the past four years, states all over the country have been plagued with revenue shortfalls in their state Medicaid budgets. While the fiscal situation improved for most states in the 2004 legislative session, many states still face budget pressures in 2005. Compounding existing budget pressures are threats from the Bush Administration to shift increased costs of the Medicaid program on to the states. All things considered, the economic pressure of funding Medicaid is at the top of legislative agendas in 2005. As in previous years, states are attempting to reduce costs to their Medicaid programs by seeking savings in their pharmaceutical programs. Prescription drug costs are highly attributed as a contributing factor to the fiscal climate of state Medicaid programs. Currently, prescription drug spending outpaces that of every other category of health care and drug prices are rising faster than inflation. In response, states are instituting a variety of pharmaceutical cost control measures such as creating preferred drug lists (PDLs), negotiating supplemental rebates, forming bulk purchasing pools, promoting generic drug substitution and implementing price controls. As prescription drug cost containment tools have gained acceptance and momentum, they continue to be controversial. This issue brief explores the debate, history, methodology, utilization and 2005 legislative activity surrounding the most commonly used and emerging pharmaceutical cost control measures. PMID:16708455

  19. Emotional Development: 1 Year Olds

    MedlinePLUS

    ... Español Text Size Email Print Share Emotional Development: 1 Year Olds Article Body Throughout her second year, your ... for shelter. She may seem to change from one moment to the next, or she may seem ...

  20. YEAR 2 BIOMASS UTILIZATION

    SciTech Connect

    Christopher J. Zygarlicke

    2004-11-01

    This Energy & Environmental Research Center (EERC) Year 2 Biomass Utilization Final Technical Report summarizes multiple projects in biopower or bioenergy, transportation biofuels, and bioproducts. A prototype of a novel advanced power system, termed the high-temperature air furnace (HITAF), was tested for performance while converting biomass and coal blends to energy. Three biomass fuels--wood residue or hog fuel, corn stover, and switchgrass--and Wyoming subbituminous coal were acquired for combustion tests in the 3-million-Btu/hr system. Blend levels were 20% biomass--80% coal on a heat basis. Hog fuel was prepared for the upcoming combustion test by air-drying and processing through a hammer mill and screen. A K-Tron biomass feeder capable of operating in both gravimetric and volumetric modes was selected as the HITAF feed system. Two oxide dispersion-strengthened (ODS) alloys that would be used in the HITAF high-temperature heat exchanger were tested for slag corrosion rates. An alumina layer formed on one particular alloy, which was more corrosion-resistant than a chromia layer that formed on the other alloy. Research activities were completed in the development of an atmospheric pressure, fluidized-bed pyrolysis-type system called the controlled spontaneous reactor (CSR), which is used to process and condition biomass. Tree trimmings were physically and chemically altered by the CSR process, resulting in a fuel that was very suitable for feeding into a coal combustion or gasification system with little or no feed system modifications required. Experimental procedures were successful for producing hydrogen from biomass using the bacteria Thermotoga, a deep-ocean thermal vent organism. Analytical procedures for hydrogen were evaluated, a gas chromatography (GC) method was derived for measuring hydrogen yields, and adaptation culturing and protocols for mutagenesis were initiated to better develop strains that can use biomass cellulose. Fly ash derived from cofiring coal with waste paper, sunflower hulls, and wood waste showed a broad spectrum of chemical and physical characteristics, according to American Society for Testing and Materials (ASTM) C618 procedures. Higher-than-normal levels of magnesium, sodium, and potassium oxide were observed for the biomass-coal fly ash, which may impact utilization in cement replacement in concrete under ASTM requirements. Other niche markets for biomass-derived fly ash were explored. Research was conducted to develop/optimize a catalytic partial oxidation-based concept for a simple, low-cost fuel processor (reformer). Work progressed to evaluate the effects of temperature and denaturant on ethanol catalytic partial oxidation. A catalyst was isolated that had a yield of 24 mole percent, with catalyst coking limited to less than 15% over a period of 2 hours. In biodiesel research, conversion of vegetable oils to biodiesel using an alternative alkaline catalyst was demonstrated without the need for subsequent water washing. In work related to biorefinery technologies, a continuous-flow reactor was used to react ethanol with lactic acid prepared from an ammonium lactate concentrate produced in fermentations conducted at the EERC. Good yields of ester were obtained even though the concentration of lactic acid in the feed was low with respect to the amount of water present. Esterification gave lower yields of ester, owing to the lowered lactic acid content of the feed. All lactic acid fermentation from amylose hydrolysate test trials was completed. Management activities included a decision to extend several projects to December 31, 2003, because of delays in receiving biomass feedstocks for testing and acquisition of commercial matching funds. In strategic studies, methods for producing acetate esters for high-value fibers, fuel additives, solvents, and chemical intermediates were discussed with several commercial entities. Commercial industries have an interest in efficient biomass gasification designs but are waiting for economic incentives. Utility, biorefinery, pulp and paper, or o

  1. Comparison of the effects block and traditional schedules have on the number of students who are proficient on the Biology End-of-Course Test in forty public high schools in the state of North Carolina

    NASA Astrophysics Data System (ADS)

    Bonner, Tonia Anita

    This study examined the difference between the number of overall students, African-American students, and students with disabilities on a semester 4 x 4 block schedule who were proficient on the North Carolina Biology End-of-Course Test and the number of the same group of students on a traditional 45-50 minute yearlong schedule who were proficient on the NC Biology End-of-Course Test in the state of North Carolina during the 2009--2010 school year. A causal-comparative design was used and three null hypotheses were tested using chi-square analysis. Archival data was used. The results showed that there was a significant association between the number of the overall students and African-American students who were proficient on the NC Biology EOC Test when taught biology on a 4 x 4 semester block versus a traditional schedule. However, no statistically significant relationship existed between the number of students with disabilities who were educated on 4 x 4 semester block schedule and those students with disabilities who were educated on a six or seven period traditional schedule in biology. Suggestions for further research are included.

  2. Health information science at the University of Victoria: the first ten years.

    PubMed

    Protti, D J

    1994-06-01

    The University of Victoria has the only program in Canada offering a Bachelor of Science degree in Health Information Science. To meet the requirements of the degree, students must complete 40 courses and 4 CO-OP work terms over 4.3 years. The School admits 30 students each September of which 60% are normally female. Seventy-five percent of the students come from British Columbia, ranging in age from 18 to 42 with the average age being 26 years. In addition to recent high school graduates, over 40% have previous degrees or diplomas, and 65% have over 5 years of work experience. The School's teaching team consists of 5 full-time faculty, 3 professional staff and 4 part-time faculty. The majority of the faculty have health backgrounds, totalling 135 person-years of practising health care experience. As of November 1992, the School had 113 graduates; 75% are employed in British Columbia, 18% are in other parts of Canada and 7% outside the country. Forty-five percent of the graduates work in government departments including community health agencies; 29% work in hospitals; 26% work in management consulting firms, software houses, or computer hardware firms. They work as systems/project analysts, systems consultants, research assistants, planning analysts, system-support staff, trainers/developers and client account representatives. Some are already in senior management positions. PMID:8072413

  3. Changes in Exercise Capacity of Cardiac Asymptomatic Hereditary Hemochromatosis Subjects over 5-Year Follow up

    PubMed Central

    Shizukuda, Yukitaka; Smith, Kevin P.; Tripodi, Dorothy J.; Arena, Ross; Yau, Yu-Ying; Bolan, Charles D.; Waclawiw, Myron A.; Leitman, Susan F.; Rosing, Douglas R.

    2012-01-01

    Objective A long-term effect of hereditary hemochromatosis (HH) on aerobic exercise capacity (AEC) has not been well described. Design Forty-three HH and 21 volunteer control (VC) subjects who were asymptomatic underwent cardiopulmonary exercise testing using the Bruce protocol. AEC was assessed with minute ventilation (VE), oxygen uptake (VO2), and carbon dioxide production (VCO2) at baseline (BL) at a 5-year follow up (5Y) assessment. A paired t-test was used for analyses of normality data; otherwise, a Wilcoxon singed rank sum test was used. Results Thirty-three HH subjects and 18 VC subjects returned for a repeat CPX at 5Y (80% overall return rate). At 5Y, AEC was not different between the two groups. As compared with BL measurements, exercise time, peak VO2, and the VE/VCO2 slope did not differ statistically at 5Y between both groups. Iron depletion by phlebotomy for 5 years did not significantly affect AEC in newly diagnosed HH subjects at baseline (n=14) and cardiac arrhythmias during exercise tended to decrease after 5 years of therapy in this group. Conclusions The AEC of asymptomatic HH subjects treated with conventional therapy is not statistically affected by the disease over a 5-year period. PMID:22311055

  4. ADS on WWW: Doubling Yearly for Five Years

    Microsoft Academic Search

    M. J. Kurtz; G. Eichhorn; A. Accomazzi; C. S. Grant; S. S. Murray

    1998-01-01

    It is now five years since the NASA ADS Abstract Service became available on the World Wide Web, in late winter of 1994. Following the explosive growth of the service (when compared with the old propriatory network access system) in the early months of WWW service, ADS growth has settled to doubling yearly. Currently ADS users make 440,000 queries per

  5. ANNA: 20 years of progress.

    PubMed

    Jordan, P S

    1989-05-01

    Editor's note--The year 1989 marks the 20th year of progress for the American Nephrology Nurses' Association (ANNA). In this special anniversary issue, Journal staff and advisors have taken time to reflect back on the historical events and leaders who helped form the association. This article examines ANNA's history year by year, from the struggles and visions of a small group of nephrology nurses who founded the organization in Atlantic City, New Jersey in April 1969 to the association's position today as a leader in professional nursing and as a promoter of quality care to nephrology patients. PMID:2658868

  6. First Quarter Hanford Seismic Report for Fiscal Year 2008

    SciTech Connect

    Rohay, Alan C.; Sweeney, Mark D.; Hartshorn, Donald C.; Clayton, Ray E.; Devary, Joseph L.

    2008-03-21

    The Hanford Seismic Assessment Program (HSAP) provides an uninterrupted collection of high-quality raw and processed seismic data from the Hanford Seismic Network for the U.S. Department of Energy and its contractors. The Hanford Seismic Assessment Team locates and identifies sources of seismic activity and monitors changes in the historical pattern of seismic activity at the Hanford Site. The data are compiled, archived, and published for use by the Hanford Site for waste management, natural phenomena hazards assessments, and engineering design and construction. In addition, the seismic monitoring organization works with the Hanford Site Emergency Services Organization to provide assistance in the event of a significant earthquake on the Hanford Site. The Hanford Seismic Network and the Eastern Washington Regional Network consist of 41 individual sensor sites and 15 radio relay sites maintained by the Hanford Seismic Assessment Team. For the Hanford Seismic Network, forty-four local earthquakes were recorded during the first quarter of fiscal year 2008. A total of thirty-one micro earthquakes were recorded within the Rattlesnake Mountain swarm area at depths in the 5-8 km range, most likely within the pre-basalt sediments. The largest event recorded by the network during the first quarter (November 25, 2007 - magnitude 1.5 Mc) was located within this swarm area at a depth of 4.3 km. With regard to the depth distribution, three earthquakes occurred at shallow depths (less than 4 km, most likely in the Columbia River basalts), thirty-six earthquakes at intermediate depths (between 4 and 9 km, most likely in the pre-basalt sediments), and five earthquakes were located at depths greater than 9 km, within the crystalline basement. Geographically, thirty-eight earthquakes occurred in swarm areas and six earth¬quakes were classified as random events.

  7. Outlook: The Next Twenty Years

    SciTech Connect

    Murayama, Hitoshi

    2003-12-07

    I present an outlook for the next twenty years in particle physics. I start with the big questions in our field, broken down into four categories: horizontal, vertical, heaven, and hell. Then I discuss how we attack the bigquestions in each category during the next twenty years. I argue for a synergy between many different approaches taken in our field.

  8. Kyoto University 1 Year Contents

    E-print Network

    Takada, Shoji

    1949 Reorganized on four-year schooling basis (with the exception of six years for medicine) under the new education system. Faculty of Education established. Branch School established for general education of freshmen and sophomores. 1951 Disaster Prevention Research Institute established. 1953 Graduate

  9. Kyoto University 1 Year Contents

    E-print Network

    Takada, Shoji

    Renamed Kyoto University 1949 Reorganized on four-year schooling basis (with the exception of six years for medicine) under the new education system. Faculty of Education established. Branch School established for general education of freshmen and sophomores. 1951 Disaster Prevention Research Institute established

  10. Reaching First Year College Students

    Microsoft Academic Search

    Mary Kate Boyd-Byrnes; Dona McDermott

    2007-01-01

    In light of the new emphasis on information literacy, this research updates previous studies and explores current practices in first year library instruction and programming. Academic librarians are reaching out to freshmen seminar programs, first year orientations, Introduction to College courses, and English composition courses to integrate information-literacy instruction into the curriculum of these programs. This study will examine how

  11. Language Development: 2 Year Olds

    MedlinePLUS

    ... Stages Listen Español Text Size Email Print Share Language Development: 2 Year Olds Article Body Your two-year-old not only understands most of what you say to him, but also speaks with a rapidly growing vocabulary of fifty ... how he also is using language to describe ideas and information and to express ...

  12. Language Development: 1 Year Olds

    MedlinePLUS

    ... Stages Listen Español Text Size Email Print Share Language Development: 1 Year Olds Article Body Early in the second year, your toddler will ... Teach him the correct names of objects and body parts, and stop using cute substitutes ... By providing a good language model, you’ll help him learn to talk ...

  13. FISCAL YEAR 20032004 FINANCIAL REPORT

    E-print Network

    FISCAL YEAR 2003­2004 FINANCIAL REPORT to the board of overseers of HARVARD COLLEGE #12;2 Letter's fiscal 2004 financial report. This past year the University has made significant progress in examining from the President 4 Letter to the Board of Overseers 8 Analysis of financial results 16 Review

  14. Vaccination coverage among children in kindergarten - United States, 2012-13 school year.

    PubMed

    2013-08-01

    State and local school vaccination requirements are implemented to maintain high vaccination coverage and minimize the risk from vaccine preventable diseases. To assess school vaccination coverage and exemptions, CDC annually analyzes school vaccination coverage data from federally funded immunization programs. These awardees include 50 states and the District of Columbia (DC), five cities, and eight U.S.-affiliated jurisdictions. This report summarizes vaccination coverage from 48 states and DC and exemption rates from 49 states and DC for children entering kindergarten for the 2012-13 school year. Forty-eight states and DC reported vaccination coverage, with medians of 94.5% for 2 doses of measles, mumps, and rubella (MMR) vaccine; 95.1% for local requirements for diphtheria, tetanus toxoid, and acellular pertussis (DTaP) vaccination; and 93.8% for 2 doses of varicella vaccine among awardees with a 2-dose requirement. Forty-nine states and DC reported exemption rates, with the median total of 1.8%. Although school entry coverage for most awardees was at or near national Healthy People 2020 targets of maintaining 95% vaccination coverage levels for 2 doses of MMR vaccine, 4 doses of DTaP† vaccine, and 2 doses of varicella vaccine, low vaccination and high exemption levels can cluster within communities, increasing the risk for disease. Reports to CDC are aggregated at the state level; however, local reporting of school vaccination coverage might be accessible by awardees. These local-level data can be used to create evidence-based health communication strategies to help parents understand the risks for vaccine-preventable diseases and the benefits of vaccinations to the health of their children and other kindergarteners. PMID:23903595

  15. Stress among First and Third Year Medical Students at University Kebangsaan Malaysia

    PubMed Central

    Salam, Abdus; Mahadevan, Raynuha; Abdul Rahman, Amir; Abdullah, Norsyafiqah; Abd Harith, Aimi Aqilah; Shan, Chu Pei

    2015-01-01

    Objective: To identify the stress-prevalence and coping-strategies among University Kebangsaan Malaysia (UKM) medical students. Methods: This was an observational study conducted among 234 UKM first and third year medical students. Standardized questionnaire on stress and coping strategies was used. Stress data was related to subjective experiences on some positive and negative adjectives such as tense, relaxed etc. Positive adjectives were measured by sign “++” and “+” scoring “1” while stress-negative adjectives were measured by sign “?” and “–“ scoring “0”. Forty-eight coping items under task, emotion and avoidance strategies were measured using 5-point Likert-scale. Results: Overall stress-prevalence was 49%. Female and Malay respondents were more stressed. Significant differences of stress-level was observed between Malays and non Malays in first year (p=0.04) and in third year (p=0.01). Most common strategies used to cope stress was task-oriented while emotion oriented was least. Conclusion: Stress-prevalence and stress-level in UKM medical students was high. Most of the respondents coped stress using task-oriented strategies. Stressor and its effective management must be ensured. Educational institutions should act as a creative designer of learning environment to get relieve from educational stressor. PMID:25878637

  16. Number of mammography cases read per year is a strong predictor of sensitivity

    PubMed Central

    Suleiman, Wasfi I.; Lewis, Sarah J.; Georgian-Smith, Dianne; Evanoff, Michael G.; McEntee, Mark F.

    2014-01-01

    Abstract. Early detection of breast cancers affects the 5-year recurrence rates and treatment options for diagnosed patients, and consequently, many countries have instituted nationwide screening programs. This study compared the performance of expert radiologists from Australia and the United States in detection of breast cancer. Forty-one radiologists, 21 from Australia and 20 from the United States, reviewed 30 mammographic cases containing two-view mammograms. Twenty cases had abnormal findings and 10 cases had normal findings. Radiologists were asked to locate malignancies and assign a level of confidence. A jackknife free-response receiver operating characteristic, figure of merit (JAFROC, FOM), inferred receiver operating characteristic, area under curve (ROC, AUC), specificity, sensitivity, and location sensitivity were calculated using Ziltron software and JAFROC v4.1. A Mann-Whitney U test was used to compare the performance of Australian and U.S. radiologists. The results showed that when experience and the number of mammograms read per year were taken into account, the Australian radiologists sampled showed significantly higher sensitivity and location sensitivity (p?0.001). JAFROC (FOM) and inferred ROC (AUC) analysis showed no difference between the overall performance of the two countries. ROC (AUC) and location sensitivity were higher for the Australian radiologists who read the most cases per year.

  17. Visualizing Twenty Years of Applications

    SciTech Connect

    Potel, Mike; Wong, Pak C.

    2014-11-01

    This issue of IEEE Computer Graphics and Applications marks the 20th anniversary of the Applications department as a regular feature of the magazine. We thought it might be interesting to look back at the 20 years of Applications department articles to assess its evolution over that time. By aggregating all twenty years of articles and applying a little statistical and visual analytics, we’ve uncovered some interesting characteristics and trends we thought we’d share to mark this 20 year milestone.

  18. Social Development:: 2 Year Olds

    MedlinePLUS

    ... Stages Listen Español Text Size Email Print Share Social Development: 2 Year Olds Article Body By nature, ... and they serve as valuable rehearsals for future social encounters. They’ll also help you appreciate the ...

  19. Today's Date_______/________/________ (Month) (Day) (Year)

    E-print Network

    Massachusetts at Amherst, University of

    Today's Date_______/________/________ (Month) (Day) (Year) Private Swim Instruction Fees/Packages **Registrant must have current recreation membership to participate in private swim lessons** 1 Lesson $25 3_____________________________________________________________________________________ (Last) (First) (MI) UCard# __________________________________________ Age________________ Male Female

  20. First Year: Clear, cold day

    E-print Network

    Chapman, Michael S.

    First Year: A Gap [I] Clear, cold day Girl sitting on the corner Pile of stained napkins Bright red is invading my brain But Somewhere between the Knowing and Helping There is a gap. By Julia Armendariz, MS1

  1. Neurodevelopmental Consequences of Early Traumatic Brain Injury in 3-Year-Old Children

    PubMed Central

    Keenan, Heather T.; Hooper, Stephen R.; Wetherington, Crista E.; Nocera, Maryalice; Runyan, Desmond K.

    2008-01-01

    OBJECTIVES The purpose of this work was to determine cognitive and adaptive behavioral outcomes of children with traumatic brain injury acquired before age 2 years and to compare outcomes between inflicted versus noninflicted brain injury. PATIENTS AND METHODS All of the North Carolina children hospitalized in an ICU for a traumatic brain injury before age 2 years between the years 2000 and 2001 were eligible for study entry. A total of 112 surviving children were prospectively identified, 52 (46%) of whom had complete follow-up. Thirty-one control children were recruited from preschool settings. Control subjects were chosen to be demographically similar to case subjects. Child measures of cognition and adaptive behavior at age 3 years were measured and compared between children with and without traumatic brain injury and children with inflicted and noninflicted traumatic brain injury. RESULTS Sixty percent of injured children were >1 SD below normal on cognitive testing. Forty percent of injured children scored >1 SD below normal on adaptive behavior testing. Children with inflicted traumatic brain injury performed more poorly on tests of cognition and adaptive behavior. Glasgow Coma Scale ?13, absence of seizures, income above twice the poverty guidelines, and high social capital were associated with improved outcomes. Injured children had lower scores than uninjured control children after adjustment for socioeconomic status. CONCLUSIONS Very young children with mild-to-severe traumatic brain injury as measured by the Glasgow Coma Scale are at risk for global cognitive deficits more than a year after the time of injury. Inflicted brain injury is associated with more severe injury and worse outcomes. This is less optimistic than findings in this same cohort 1 year after injury. Family characteristics seem to play a role in recovery after injury. PMID:17332181

  2. Welcome to the New Year!

    Microsoft Academic Search

    Damian P Hampshire

    2008-01-01

    I have the privilege of taking over from Professor Gordon Donaldson as Editor-in-Chief of Superconductor Science and Technology (SuST) for the next two years. During the last ten years, he has refereed several thousand papers and ensured that SuST has the highest impact factor of any specialist journal in the field. It is a pleasure to take this opportunity to

  3. Vagus nerve stimulation and magnet use: Optimizing benefits

    Microsoft Academic Search

    William O. Tatum IV; Sandra L. Helmers

    2009-01-01

    More than 10years ago, the vagus nerve stimulator became the first device approved by the Food and Drug Administration for use in persons with epilepsy. The vagus nerve stimulator has subsequently served to spearhead the concept of neurostimulation for seizures. Chronic intermittent electrical stimulation of the left vagus nerve is the foundation for vagus nerve stimulation, yet little is known

  4. Power of the metaphor: forty signs on brain imaging.

    PubMed

    Gocmen, Rahsan; Guler, Ezgi; Kose, Ilgaz Cagatay; Oguz, Kader K

    2015-01-01

    We retrospectively reviewed neuroradiology database at our tertiary-care hospital to search for patients with metaphoric or descriptive signs on brain computed tomography or magnetic resonance imaging. Only patients who had clinical or pathological definitive diagnosis were included in this review. PMID:24593052

  5. Mental Health and Teacher Education. Forty-Sixth Yearbook, 1967.

    ERIC Educational Resources Information Center

    Association for Student Teaching, Washington, DC.

    Ten papers constitute the major portion of this book: "The Classroom Teacher, Mental Health, and Learning," Robert E. Bills; "The Development of Selected Aspects of the Mental Health Movement in Teacher Education," Ralph H. Ojemann; "What Psychology Has To Offer to Teacher Education," Carl R. Rogers; "Conceptual Framework for Teacher Education,"…

  6. Sibling incest: reports from forty-one survivors.

    PubMed

    Carlson, Bonnie E; Maciol, Katherine; Schneider, Joanne

    2006-01-01

    An exploratory study was conducted with a convenience sample of 41 adult survivors of sibling incest using a retrospective survey design. Participants were interviewed about their childhood sexual experiences with a sibling. Most participants reported vaginal or oral intercourse and coercive experiences. Half of the sample reported sexual experiences with family members, as well as other child abuse. Half of the participants showed evidence of distorted beliefs about child sexual abuse. Disclosure of the incest during childhood was rare. doi:10.1300/ J070v15n04_02. PMID:17200052

  7. Sibling Incest: Reports from Forty-One Survivors

    ERIC Educational Resources Information Center

    Carlson, Bonnie E.; Maciol, Katherine; Schneider, Joanne

    2006-01-01

    An exploratory study was conducted with a convenience sample of 41 adult survivors of sibling incest using a retrospective survey design. Participants were interviewed about their childhood sexual experiences with a sibling. Most participants reported vaginal or oral intercourse and coercive experiences. Half of the sample reported sexual…

  8. Naive (Bayes) at forty: The independence assumption in information retrieval

    Microsoft Academic Search

    David D. Lewis

    1998-01-01

    The naive Bayes classifier, currently experiencing a\\u000a renaissance in machine learning, has long been a core\\u000a technique in information retrieval. We review some of the\\u000a variations of naive Bayes models used for text retrieval\\u000a and classification, focusing on the distributional\\u000a assumptions made about word occurrences in documents.

  9. Multivariate statistical analyses of groundwater surrounding Forty mile wash

    SciTech Connect

    Woocay, A.; Walton, J.C. [El Paso Univ. of Texas, Environmental Science and Engineering, TX (United States)

    2007-07-01

    Groundwater chemistry data from 211 sampling locations in the vicinity of Yucca Mountain, Nevada are analyzed using multivariate statistical methods in order to better understand groundwater chemical evolution, ascertain potential flow paths and determine hydrochemical facies. Correspondence analysis of the major ion chemistry is used to define relationships between and among major ions and sampling locations. A k-means cluster analysis is used to determine hydrochemical facies based on correspondence analysis dimensions. The derived dimensions and hydrochemical facies are presented as bi-plots and overlaid on a digital elevation model of the region giving a visual picture of potential interactions and flow paths. A distinct signature of the groundwater chemistry along the extended flow path of Fortymile Wash can be observed along with some potential interaction at possible fault lines near Highway I-95. The signature from Fortymile Wash is believed to represent the relict of water that infiltrated during past pluvial periods when the amount of runoff in the wash was significantly larger than during the current drier period. This hypothesis appears to be supported by hydrogen-2 and oxygen-18 data which indicate that younger groundwater is found in the upper part of the wash near Yucca Mountain and older groundwater is found in the lower region of the wash near Amargosa River. The range of the hydrogen-2 data corresponds to precipitation in a period of relatively cold climate and has a similar spatial signature to the oxygen-18 data. If the hypothesis that current groundwater chemistry primarily reflects past focused infiltration of surface runoff rather than regional groundwater migration is correct, then saturated zone transport from Yucca Mountain may be much slower than is currently anticipated. (authors)

  10. Warner-Bratzler Shear evaluations of forty bovine muscles 

    E-print Network

    Belew, Jason Burl

    2000-01-01

    one-inch (2.54 cm) steaks as possible. Each steak was numbered to identify muscle and location within muscle. Steaks were packaged, allowed to age for fourteen days, then frozen until cooked. Steaks were thawed, cooked, chilled and evaluated...

  11. [Pregnancy in the adolescent: report on forty-six cases].

    PubMed

    Madi, J M; Chiaradia, A; Lunardi, P V

    1986-01-01

    46 pregnant teenagers were analyzed from the obstetric viewpoint, and the findings were correlated with an evaluation of theier newborns in their 1st days of life. The low index of concomitant pathologies shown in this Brazilian study could be related to the process of seeking prenatal care and the perceptual changes in the teenager's psychosocial profile. It was surprise to find that this group was seeking prenatal care; few adverse situation were observed. It is believed that in this clinic basic information on birth-related diet, hygiene, and physiology could be, and was, given to the pregnant teenager. Prenatal care is the most important factor in the evolution of pregnancy in this type of patient. The changes in the psychosocial patterns are created by those who are in contact with and influence the groups' school of thought on a daily basis. This small casuistry characterizes an important social situation that in some ways can contribute to new considerations. Prenatal care needs to be encouraged to combat the negative results arising from a lack of these services. The gap created between pediatricians and gynecologists, in which these teenagers find themselves, will be closed as these 2 professions are geared by training to care for the pregnant teenagers. PMID:12268685

  12. Forty Meters from Entry to Victoria Crater (Stereo)

    NASA Technical Reports Server (NTRS)

    2007-01-01

    [figure removed for brevity, see original site] Left-eye view of a color stereo pair for PIA09972 [figure removed for brevity, see original site] Right-eye view of a color stereo pair for PIA09972

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this stereo view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view combines a stereo pair and appears three-dimensional when seen through blue-red glasses. It is presented as a cylindrical-perspective projection with geometric seam correction.

  13. Forty Meters from Entry to Victoria Crater (Polar)

    NASA Technical Reports Server (NTRS)

    2007-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view is presented as a polar projection with geometric seam correction.

  14. Forty Meters from Entry to Victoria Crater (Vertical)

    NASA Technical Reports Server (NTRS)

    2007-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view is presented as a vertical projection with geometric seam correction.

  15. BBN Report-8528 Forty Data Communications Research Questions

    E-print Network

    Partridge, Craig

    This report was approved for public distribution per BBN policy on 11 January 2011, Dave Clark has periodically observed that other fields sometimes find it useful to create a list's a loss, as pursuing less pressing problems sometimes yields results that can help with immediate needs

  16. Condensed Matter Physics in Colombia is in its forties

    NASA Astrophysics Data System (ADS)

    Camacho, Angela

    2015-03-01

    Physics in Colombia started to develop in the 70's as a research part of basic sciences with the acquisition, at that time, of large research equipments such as x-rays and EPR. Experimental work was soon supplemented by theoretical investigations, which led to the formation of research groups in condensed matter. In the early 80's existed such groups in five universities. In this report we present, after a short history of the main steps that guided the initial research subjects, the major areas already developed and the minor research groups that are in the stage of consolidation. Currently this type of work is done at least in 20 universities. We also show the actual numbers of researchers, publications, PhD students and laboratories discriminated in gender to complete an overview of Condensed Matter Physics in Colombia. Finally, we present a short review of the main theoretical issues that have been worked in the last decade focusing on low dimensional systems, their structural and optical properties

  17. Consistency of children's dietary choices: annual repeat measures from 5 to 13 years (EarlyBird 49).

    PubMed

    Frémeaux, Alissa E; Hosking, Joanne; Metcalf, Brad S; Jeffery, Alison N; Voss, Linda D; Wilkin, Terence J

    2011-09-01

    The objective of the present study was to explore the consistency of dietary choices made by children as they grow up. The dietary habits of 342 healthy children were reported annually from 5 to 13 years on a forty-five-item FFQ and analysed by factor analysis. The same two principal dietary patterns--'Healthy' and 'Unhealthy'--emerged each year, and their consistency was assessed using Tucker's congruence coefficient (?). Individual dietary z-scores for both of these patterns were then calculated every year for each child, and their consistency was measured by Pearson's correlation coefficient (r). Linear mixed-effects modelling was used to investigate individual trends and to quantify reliability of the individual dietary z-scores. Dietary patterns were moderately consistent and systematic over time (0·65 ? ?Healthy ? 0·76; 0·62 ? ?Unhealthy ? 0·78). Individual choices were also consistent year-on-year (0·64 ? rHealthy ? 0·71; 0·57 ? rUnhealthy ? 0·68). Reliability rose from 70 % with a single measure to over 90 % with four consecutive measures. The quality of diet diminished over time in 29 % of the children and improved in only 14 %. Dietary habits appear to be set early and seldom improve spontaneously. PMID:21736842

  18. Acute Otitis Media during the First Two Years of Life in a Rural Community in Bangladesh: A Prospective Cohort Study

    PubMed Central

    Roy, Eliza; Hasan, Zahid; Haque, Fazlul; Siddique, A.K.M.; Sack, Richard Bradley

    2007-01-01

    The study investigated the burden of acute otitis media (AOM) during the first two years of life in a cohort of 252 newborns in rural Bangladesh using data collected on occurrences of AOM. Trained community health workers (CHWs) conducted household surveillance and picked up cases of AOM using the study algorithm. The incidence rate was 0.9 episodes per child-year observed. Forty-six percent (n=115) of the 252 subjects developed AOM: 36% (n=91) during the first year of life and 10% (n=24) during the second year of life (p<0.001). The age-specific incidence rates of AOM varied; peaks occurred in the 6-12-month age-group and the lowest in the first three months of life. In total, 20% (n=49) of the study subjects had single, 26% (n=66) recurrent, and 54% (n=137) no episode of AOM. Perforation with discharge developed in 85% (n=322) of 375 episodes. The duration of discharge from the ears was ?6 weeks in 95% of the episodes, but in 5% of the episodes, discharge from the ears continued for >6 weeks. The incidence of AOM was higher in the monsoon season compared to the summer season (p<0.003). The study documented AOM as an important cause of morbidity among rural children up to two years of age in Bangladesh and should be addressed with strategies to overcome the burden of disease. PMID:18402184

  19. Trochanteric fixation using a third-generation cable device--minimum follow-up of 3 years.

    PubMed

    Patel, Shelain; Soler, Juan A; El-Husseiny, Moataz; Pegg, Derek J; Witt, Johan D; Haddad, Fares S

    2012-03-01

    Third-generation trochanteric fixation cable systems are designed to overcome implant breakage, nonunion, and bony escape. The study prospectively assessed the functional and radiologic outcomes using such an implant. Forty-seven trochanteric fixations in 46 patients were performed over 4 years at 2 institutions using the Accord Cable Plate system (Smith and Nephew, Memphis, Tenn). Serial evaluation at a mean follow-up of 57 months demonstrated that the mean Harris hip scores improved from 52.3 preoperatively to 88.2 postoperatively (P < .001), and the mean pain score improved from 6.2 to 2.3, respectively (P < .001). No cable breakage, fretting, or fraying occurred. There were 2 cases of nonunion. A third-generation cable system appears to improve upon early-generation implants and provide favorable outcomes for reattachment of a trochanteric fragment in a variety of clinical scenarios. PMID:21908164

  20. 35 years of DEB research

    NASA Astrophysics Data System (ADS)

    van der Meer, Jaap; Klok, Chris; Kearney, Michael R.; Wijsman, Jeroen W. M.; Kooijman, Sebastiaan A. L. M.

    2014-11-01

    Research on the Dynamic Energy Budget (DEB) theory started 35 years ago. Initially much emphasis was put on the development of a consistent theory. During recent years attention was paid on parameterizing DEB models for a huge collection of species. This enables the search for patterns in parameter values in an ecological and evolutionary context. This special issue presents some of the results of this quest, among other things focusing on the development of metabolic acceleration, combined with various applications of DEB theory in fisheries, aquaculture, climate science and ecotoxicology.

  1. Adoption of a wiki within a large internal medicine residency program: a 3-year experience

    PubMed Central

    Mostaghimi, Arash; Reynolds, Eileen E

    2011-01-01

    Objective To describe the creation and evaluate the use of a wiki by medical residents, and to determine if a wiki would be a useful tool for improving the experience, efficiency, and education of housestaff. Materials and methods In 2008, a team of medical residents built a wiki containing institutional knowledge and reference information using Microsoft SharePoint. We tracked visit data for 3?years, and performed an audit of page views and updates in the second year. We evaluated the attitudes of medical residents toward the wiki using a survey. Results Users accessed the wiki 23?218, 35?094, and 40?545 times in each of three successive academic years from 2008 to 2011. In the year two audit, 85 users made a total of 1082 updates to 176 pages and of these, 91 were new page creations by 17 users. Forty-eight percent of residents edited a page. All housestaff felt the wiki improved their ability to complete tasks, and 90%, 89%, and 57% reported that the wiki improved their experience, efficiency, and education, respectively, when surveyed in academic year 2009–2010. Discussion A wiki is a useful and popular tool for organizing administrative and educational content for residents. Housestaff felt strongly that the wiki improved their workflow, but a smaller educational impact was observed. Nearly half of the housestaff edited the wiki, suggesting broad buy-in among the residents. Conclusion A wiki is a feasible and useful tool for improving information retrieval for house officers. PMID:22140210

  2. Long-term Changes in Pulmonary Function After Incidental Lung Irradiation for Breast Cancer: A Prospective Study With 7-Year Follow-up

    SciTech Connect

    Jaen, Javier, E-mail: javier.jaen.sspa@juntadeandalucia.es [Unidad de Atencion Integral al Cancer, Hospital Universitario Puerta del Mar, Cadiz (Spain)] [Unidad de Atencion Integral al Cancer, Hospital Universitario Puerta del Mar, Cadiz (Spain); Vazquez, Gonzalo [Servicio de Oncologia Radioterapica, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (Spain)] [Servicio de Oncologia Radioterapica, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (Spain); Alonso, Enrique; De Las Penas, Maria D.; Diaz, Laura [Unidad de Atencion Integral al Cancer, Hospital Universitario Puerta del Mar, Cadiz (Spain)] [Unidad de Atencion Integral al Cancer, Hospital Universitario Puerta del Mar, Cadiz (Spain); De Las Heras, Manuel [Servicio de Oncologia Radioterapica, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (Spain)] [Servicio de Oncologia Radioterapica, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), Madrid (Spain); Perez-Regadera, Jose F. [Servicio de Oncologia Radioterapica, Hospital Universitario Doce de Octubre, Madrid (Spain)] [Servicio de Oncologia Radioterapica, Hospital Universitario Doce de Octubre, Madrid (Spain)

    2012-12-01

    Purpose: To evaluate late pulmonary function changes after incidental pulmonary irradiation for breast cancer. Methods and Materials: Forty-three consecutive female patients diagnosed with breast carcinoma and treated with postoperative radiation therapy (RT) at the same dose (50 Gy) and fractionation (2 Gy/fraction, 5 days/week) were enrolled. Pulmonary function tests (PFT) and ventilation/perfusion scans were performed before RT and 6, 12, 24, and 84 months afterward. Results: Forty-one patients, mean age 55 years, were eligible for the analysis. No differences were found in the baseline PFT values for age, smoking status and previous chemotherapy; women undergoing mastectomy showed baseline spirometric PFT values lower than did women treated with conservative surgery. The mean pulmonary dose was 10.9 Gy, being higher in women who also received lymph node RT (15.8 vs 8.6, P<.01). Only 1 patient experienced symptomatic pneumonitis. All PFT values showed a reduction at 6 months. From then on, the forced vital capacity and forced expiratory volume in 1 second began their recovery until reaching, and even exceeding, their baseline values at 7 years. Diffusing capacity of the lungs for carbon monoxide and ventilation/perfusion scans continued to reduce for 24 months and then partially recovered their baseline values (-3.5%, -3.8%, and -5.5%, respectively). Only the percentage difference at 7 years in the ventilation scan correlated with the dosimetric parameters studied. Other variables, such as age, smoking status, previous chemotherapy, and concomitant tamoxifen showed no significant relation with changes in PFT ({Delta}PFT) values at 7 years. Conclusions: The study of reproducible subclinical parameters, such as PFT values, shows how their figures decrease in the first 2 years but practically recover their baseline values in the long term. The extent of the reduction in PFT values was small, and there was no clear association with several dosimetric and clinical parameters.

  3. Nature of the clinical difficulties of first-year family medicine residents under direct observation.

    PubMed Central

    Beaumier, A; Bordage, G; Saucier, D; Turgeon, J

    1992-01-01

    OBJECTIVE: To determine and classify the difficulties of first-year family medicine residents observed during clinical interviews. DESIGN: Retrospective, descriptive study. SETTING: Family practice unit at a teaching hospital. PARTICIPANTS: Forty-seven of the 56 first-year family medicine residents during their 2-month compulsory rotation in ambulatory family medicine, between July 1983 and December 1988, and 4 physicians who supervised the residents. MAIN OUTCOME MEASURE: The residents' difficulties noted on the observation forms. MAIN RESULTS: A total of 1500 difficulties were observed during 194 interviews, an average of 7.7 (standard deviation 5.2) per interview. There were 167 different difficulties, which were classified into seven categories (introduction, initial contract, body of the interview, techniques and organization, interpersonal aspects, final contract and miscellaneous) and 20 subcategories. The 17 most frequently noted difficulties accounted for 40% of the total. CONCLUSIONS: The results constitute a useful starting point for developing a classification of residents' difficulties during clinical interviews. We believe that the list of difficulties is applicable to residents at all levels and in other specialties, especially in ambulatory settings. The list can be used to develop learning materials for supervisors and residents. PMID:1737313

  4. Associations between teacher emotional support and depressive symptoms in Australian adolescents: a 5-year longitudinal study.

    PubMed

    Pössel, Patrick; Rudasill, Kathleen Moritz; Sawyer, Michael G; Spence, Susan H; Bjerg, Annie C

    2013-11-01

    Approximately 1/5 of adolescents develop depressive symptoms. Given that youths spend a good deal of their lives at school, it seems plausible that supportive relationships with teachers could benefit their emotional well-being. Thus, the purpose of this study is to examine the association between emotionally supportive teacher relationships and depression in adolescence. The so-called principle-effect and stress-buffer models could explain relationships between teacher emotional support and depressive symptoms, yet no study has used both models to test bidirectional relationships between teacher support and depressive symptoms in students separately by sex. Four-thousand three-hundred forty-one students (boys: n = 2,063; girls: n = 2,278) from Grades 8 to 12 completed the Center for Epidemiological Studies Depression Scale (CES-D), List of Threatening Experiences Questionnaire (LTEQ), and an instrument developed for the study to measure teacher support annually for 5 years. Results support neither of the 2 proposed models. Instead, they indicate that in the 1st years of high school, students of both sexes with average and high numbers of stressful events benefit from teacher support, while teacher support might have iatrogenic effects on students experiencing low numbers of stressful events. Possible explanations for the findings and future research are discussed. PMID:23379297

  5. Usage of removable partial dentures in Saudi male patients after 1 year telephone interview

    PubMed Central

    Akeel, Riyadh

    2010-01-01

    Objective The success of removable partial dentures (RPDs) is partly dependent on patients’ acceptance and compliance in using them. The purpose of this study was to describe the usage of removable partial dentures (RPDs) by patients 1 year after insertion and to evaluate the factors that influence their denture usage. Methods Forty-seven patients who received 75 new RPDs at the undergraduate clinic of College of Dentistry, King Saud University, were contacted by telephone 1 year later for an interview. The questions covered denture usage, patient’s satisfaction and reasons for non-use. Results Results showed that 36% of patients discarded or occasionally used their RPDs. There was no significant association between denture usage and RPD experience, location or Kennedy classification. A significantly more RPD rejection was found when it was opposed by natural teeth or complete denture. The most quoted reason for RPD rejection was pain and discomfort. Conclusion Despite the short follow-up period, RPDs were poorly accepted by patients treated by undergraduate students. PMID:23960487

  6. Quinton-Scribner Cannulas for Hemodialysis—Review of Four Years' Experience

    PubMed Central

    Foran, Robert F.; Golding, Arthur L.; Treiman, Richard L.; De Palma, John R.

    1970-01-01

    Data on a study group of 52 maintenance hemodialysis patients cannulated with Quinton-Scribner cannula in a four-year period were analyzed. The average period of dialysis was 11.8 months with either a pumped coil or a pumpless Kiil artificial kidney system. One hundred and forty-five cannulations were performed. The mean arterial cannula survival was 7.8 months and the mean venous cannula survival was 7.2 months. The exceptional longevity of cannula survival occurred despite the high incidence of atherosclerotic changes at operation and the advanced mean age (47 years) of the patients. The cannula longevity may be partially related to the technique used and to meticulous surgical care given the patient before and after cannulation. Complications from cannulation included two deaths, one from septic pulmonary embolism of Staphylococcus origin, and one from acute Pseudomonas endocarditis. A total of 36 infections of cannulas were recognized, the majority being due to Staphylococcus aureus, but 28 percent being secondary to Gram-negative bacteria. PMID:5451620

  7. Employment Initiatives. Third Year Report.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Human Resources, Baltimore.

    The third operational year of the Employment Initiatives (EI) saw expansion throughout Maryland with the addition of new projects in Anne Arundel, Allegany, Dorchester, Frederick, and Harford counties during October 1984. In July 1985, other projects were funded in Baltimore City, Southern Maryland, and Montgomery County. EI offered a package of…

  8. Employment Initiatives. Second Year Report.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Human Resources, Baltimore.

    During its second year, Maryland's Employment Initiatives (EI) program continued to help Aid for Dependent Children applicants and recipients obtain unsubsidized employment. It provided employment and training opportunities to Work Incentive Demonstration Program participants at two sites: Baltimore City (OPTIONS) and Wicomico County (Basic…

  9. EDITORIAL: Chernobyl20 years on

    Microsoft Academic Search

    Richard Wakeford

    2006-01-01

    Twenty years ago on 26 April 2006, the Chernobyl nuclear reactor accident occurred (or, more precisely, the explosion that marked the start of the accident occurred - the resultant fire lasted several days). This is by far the largest unintentional release of radioactive material into the environment and caused widespread contamination in Europe, which was sufficiently great in the vicinity

  10. Fifty Years of Aeronautical Research.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This booklet contains a detailed review of the aeronautical research conducted at Langley Research Center during the 50 years after its construction in 1917 as the first research laboratory for the National Advisory Committee for Aeronautics. The research is discussed in five parts, by decades: 1917-27, 1928-37, 1938-47, 1948-57, 1958-67.…

  11. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 01400 GENERAL BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 01300 GENERAL BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY

  12. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIOL 117 + BIOL 118 GENERAL BIOLOGY II and LAB Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIOL 115 + BIOL 116 GENERAL BIOLOGY I and LAB Introductory Chemistry

  13. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BI 202 GENERAL BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BI 201 GENERAL BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY CHEMISTRY

  14. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 152 / BY 52 MODERN BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 150 / BY 50 MODERN BIOLOGY I Introductory Chemistry with labs Chemistry 107

  15. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY SC 139 INTRODUCTORY BIOLOGY: ANIMALS AND PLANTS Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY SC 135 INTRODUCTORY BIOLOGY: MOLECULES AND CELLS Introductory Chemistry

  16. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 156 GENERAL BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 155 GENERAL BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY

  17. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 116 GENERAL BIOLOGY 2 Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 115 GENERAL BIOLOGY 1 Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY

  18. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIOL 102 GENERAL BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIOL 101 GENERAL BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY

  19. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 220 BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 210 BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY CHEMISTRY I CHE 201

  20. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 110 PRINCIPLES OF BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 109 PRINCIPLES OF BIOLOGY I Introductory Chemistry with labs Chemistry 107

  1. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIOL 1520 GENERAL BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIOL 1510 GENERAL BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY

  2. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 1580 PRINCIPLES OF BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 1570 PRINCIPLES OF BIOLOGY I Introductory Chemistry with labs Chemistry 107

  3. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIOL 105 GENERAL BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIOL 104 GENERAL BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY

  4. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 132 PRINCIPLES OF BIOLOGY 2 Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 131 PRINCIPLES OF BIOLOGY 1 Introductory Chemistry with labs Chemistry 107

  5. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 152 GENERAL BIOLOGY I Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 151 GENERAL BIOLOGY II Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY

  6. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BI 102 GENERAL BIOLOGY 2 Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BI 101 GENERAL BIOLOGY 1 Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY CHEMISTRY

  7. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 102 GENERAL BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 101 GENERAL BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY

  8. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 117 PRINCIPLES OF BIOLOGY I Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BIO 118 PRINCIPLES OF BIOLOGY II Introductory Chemistry with labs Chemistry 107

  9. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BIO 106H GENERAL BIOLOGY II HONORS Biology 118 INTRODUCTION TO CELLULAR AND MOLECULAR BIOLOGY BIO 105H GENERAL BIOLOGY I HONORS Introductory Chemistry with labs Chemistry 107

  10. BIOLOGY MAJOR First two years

    E-print Network

    Suzuki, Masatsugu

    BIOLOGY MAJOR First two years Introductory Biology with labs Biology 117 AND INTRODUCTION TO ORGANISMAL AND POPULATION BIOLOGY BI 102 GENERAL BIOLOGY II Biology 118 INTRODUCTION TO CELL AND MOLECULAR BIOLOGY BI 101 GENERAL BIOLOGY I Introductory Chemistry with labs Chemistry 107 AND INTRODUCTORY CHEMISTRY

  11. Intestinal amoebiasis for 36 years

    Microsoft Academic Search

    J. H. Johnston; J. B. Stewart; D. M. Roberts

    1980-01-01

    A case is reported of amoebic dysentery in a former soldier who had symptoms of Entamoeba histolytica infection for 36 years. It emphasizes the need for careful search for parasites in the stools of any patient with bowel symptoms because the consequences of wrong diagnosis are potentially catastrophic.

  12. CEC Teacher of the Year.

    ERIC Educational Resources Information Center

    Voyles, Lynda

    1995-01-01

    This interview with Brenda Jean Robbins, a Florida music therapist and teacher selected as 1995 Teacher of the Year by the Council for Exceptional Children, reveals her views about music therapy, goals, relationship of music therapy to the special education classroom, musical performance, and getting parents involved. (DB)

  13. Extramural Activities, Fiscal Year 1969.

    ERIC Educational Resources Information Center

    National Inst. of Child Health and Human Development (NIH), Bethesda, MD.

    The Adult Development and Aging Branch of the National Institute of Child Health and Human Development supports research and training relevant to the biological and behavioral changes that occur in humans with increasing age from the adult years through maturity and old age. Supported are research projects, training projects, special and…

  14. Children's Order 10 Years on

    ERIC Educational Resources Information Center

    Kerr, Linda

    2006-01-01

    Ten years ago I wrote an article on the Children's Order, which was coming into force in Northern Ireland in October 1996. I examined the principles behind the Children's Order and considered how these principles interacted with the practice of family mediation (at that stage I was Coordinator of the Family Mediation service). Since that date…

  15. Annual Report Fiscal Year 2013

    E-print Network

    Mission The Graduate Program in Genetics provides students with a working knowledge of human functionalAnnual Report Fiscal Year 2013 LSU Health Sciences Center Department of Genetics #12;DEPARTMENT OF GENETICS ANNUAL REPORT FY 2013 Table of Contents Mission Department of Genetics Mission

  16. Cryptographic technology: fifteen year forecast

    Microsoft Academic Search

    Whitfield Diffie

    1982-01-01

    This paper examines the forces driving public development of cryptography today and projects the course of the field over the next fifteen years with attention to the possible influence of government regulation.This paper was prepared, under contractual arrangements to CRC Systems, in support of the Commerce Department (National Telecommunications and Information Administration, Special Projects Office) response to a White House

  17. Yearbook 1988. IWGIA: 20 Years.

    ERIC Educational Resources Information Center

    Gray, Andrew

    The theme of this yearbook is the work of the International Work Group for Indigenous Affairs (IWGIA) during the 20 years of its existence and the enormous growth of the indigenous movement in that time. Section 1 traces IWGIA's history and includes the annual report for 1988. Section 2 is a global view of the main events in the indigenous world…

  18. Objectives Meds Year 2 Neurophysiology

    E-print Network

    Vilis, Tutis

    in Parkinson and Huntington's disease. · Compare the motor deficits in cerebellar diseases and those of the basal ganglia in Parkinson disease. 7. Auditory Physiology · What are the functions of the middle earObjectives Meds Year 2 Neurophysiology Tutis Vilis 1. The Eye · List at least four factors that can

  19. Columbine High: Five Years Later

    ERIC Educational Resources Information Center

    Hurst, Marianne D.

    2004-01-01

    A few weeks before the fifth anniversary of the Columbine High School shootings on April 20, 1999, Principal Frank DeAngelis reflects on how his school has changed over the past five years. Much like the September 11, 2001 terrorist attacks against the United States, "Columbine" carries a chilling meaning that resonates across the country. That…

  20. Fuel ethanol after 25 years

    Microsoft Academic Search

    Alan E Wheals; Luiz C Basso; Denise M. G Alves; Henrique V Amorim

    1999-01-01

    After 25 years, Brazil and North America are still the only two regions that produce large quantities of fuel ethanol, from sugar cane and maize, respectively. The efficiency of ethanol production has steadily increased and valuable co-products are produced, but only tax credits make fuel ethanol commercially viable because oil prices are at an all-time low. The original motivation for

  1. financial report fiscal year 2013

    E-print Network

    financial report fiscal year 2013 #12;tableofcontents 2 message from the president 3 financial overview 8 message from the ceo of harvard management company 13 independent auditor's report 14 financial statements 18 notes to financial statements #12;2 harvarduniversitymessagefromthepresident I write to report

  2. Bisphosphonates: The first 40 years

    Microsoft Academic Search

    R. Graham G. Russell

    2011-01-01

    The first full publications on the biological effects of the diphosphonates, later renamed bisphosphonates, appeared in 1969, so it is timely after 40years to review the history of their development and their impact on clinical medicine.This special issue of BONE contains a series of review articles covering the basic science and clinical aspects of these drugs, written by some of

  3. Joint Honours BA in Communication and Political Science 120 credits (4 years) Total 1st year 2nd year 3rd year 4th year

    E-print Network

    Sankoff, David

    Joint Honours BA in Communication and Political Science ­ 120 credits (4 years) Total 1st year 2nd Research Methods in Communication POL2156 Foundations of Research in Political Science CMN3105 Media Ethics CMN3109 Theories of Communication CMN3130 Communication Planning CMN3133 Political Communication 3

  4. The International Year of Statistics

    NSDL National Science Digital Library

    2013-01-01

    Statistics is a subject for all seasons and years, but 2013 is the International Year of Statistics, a designation supported by almost 1,850 organizations. The primary movers behind this noble activity include the American Statistical Association, the International Biometric Society, and the Royal Statistical Society. The goal of this initiative is to promote "the importance of statistics to the scientific community, business and government data users, the media," and a range of other users. On the website, visitors can make their way through four main sections, including What is Statistics?, Statistics as a Career, Teacher Resources, and Statistics 2013 Posters. The Teacher Resources area is a real pip, as it features teacher resources for over two dozen countries, along with statistics education videos from the United States and Mexico. The site also includes a Statistic of the Day, a quote of the week, and a most efficacious Statistical Word of the Week.

  5. Quantum Tomography twenty years later

    NASA Astrophysics Data System (ADS)

    Asorey, M.; Ibort, A.; Marmo, G.; Ventriglia, F.

    2015-06-01

    We show a sample of some relevant developments in classical and quantum tomography that have taken place over the last twenty years. We will present a general conceptual framework that provides a simple unifying mathematical picture for them and, as an effective use of it, three subjects have been chosen that offer a wide panorama of the scope of classical and quantum tomography: tomography along lines and submanifolds, coherent state tomography and tomography in the abstract algebraic setting of quantum systems.

  6. 5-Year Rate Changes Graph

    Cancer.gov

    This graph provides a quick look at which cancer sites have rising rates and which have falling rates over the most recent 5 years of data. The goal is for every cancer site to have falling mortality. Incidence is a more complex story that requires local knowledge and interpretation. For example, a successful screening program will result in a short term rise in incidence. The Historical Trends graph can be used to look at the trends in rates.

  7. Light Year (l.y.)

    Microsoft Academic Search

    P. Murdin

    2000-01-01

    A unit of distance measurement equal to the distance traveled by a ray of light in vacuo in one year. Since light travels at a speed of 299 792 458 m s-1 (186 282 miles s-1), this distance is equivalent to 9.46×1012 km (i.e. 9.46 million million km) or 63 240 astronomical units. The unit is commonly used to express

  8. Spirit Begins Third Martian Year

    NASA Technical Reports Server (NTRS)

    2007-01-01

    As it finished its second Martian year on Mars, NASA's Mars Exploration Rover Spirit was beginning to examine a group of angular rocks given informal names corresponding to peaks in the Colorado Rockies. A Martian year the amount of time it takes Mars to complete one orbit around the sun lasts for 687 Earth days. Spirit completed its second Martian year on the rover's 1,338th Martian day, or sol, corresponding to Oct. 8, 2007.

    Two days later, on sol 1,340 (Oct. 10, 2007), Spirit used its front hazard-identification camera to capture this wide-angle view of its robotic arm extended to a rock informally named 'Humboldt Peak.' For the rocks at this site on the southern edge of the 'Home Plate' platform in the inner basin of the Columbia Hills inside Gusev Crater, the rover team decided to use names of Colorado peaks higher than 14,000 feet. The Colorado Rockies team of the National League is the connection to the baseball-theme nomenclature being used for features around Home Plate.

    The tool facing Spirit on the turret at the end of the robotic arm is the Moessbauer spectrometer.

  9. Earth: 15 Million Years Ago

    E-print Network

    Masataka Mizushima

    2008-10-13

    In Einstein's general relativity theory the metric component gxx in the direction of motion (x-direction) of the sun deviates from unity due to a tensor potential caused by the black hole existing around the center of the galaxy. Because the solar system is orbiting around the galactic center at 200 km/s, the theory shows that the Newtonian gravitational potential due to the sun is not quite radial. At the present time, the ecliptic plane is almost perpendicular to the galactic plane, consistent with this modification of the Newtonian gravitational force. The ecliptic plane is assumed to maintain this orientation in the galactic space as it orbits around the galactic center, but the rotational angular momentum of the earth around its own axis can be assumed to be conserved. The earth is between the sun and the galactic center at the summer solstice all the time. As a consequence, the rotational axis of the earth would be parallel to the axis of the orbital rotation of the earth 15 million years ago, if the solar system has been orbiting around the galactic center at 200 km/s. The present theory concludes that the earth did not have seasons 15 million years ago. Therefore, the water on the earth was accumulated near the poles as ice and the sea level was very low. Geological evidence exists that confirms this effect. The resulting global ice-melting started 15 million years ago and is ending now.

  10. Thirty years through vanadium chemistry.

    PubMed

    Costa Pessoa, J

    2015-06-01

    The relevance of vanadium in biological systems is known for many years and vanadium-based catalysts have important industrial applications, however, till the beginning of the 80s research on vanadium chemistry and biochemistry did not receive much attention from the scientific community. The understanding of the broad bioinorganic implications resulting from the similarities between phosphate and vanadate(V) and the discovery of vanadium dependent enzymes gave rise to an enormous increase in interest in the chemistry and biological relevance of vanadium. Thereupon the last 30years corresponded to a period of enormous research effort in these fields, as well as in medicinal applications of vanadium and in the development of catalysts for use in fine-chemical synthesis, some of these inspired by enzymatic active sites. Since the 80s my group in collaboration with others made contributions, described throughout this text, namely in the understanding of the speciation of vanadium compounds in aqueous solution and in biological fluids, and to the transport of vanadium compounds in blood plasma and their uptake by cells. Several new types of vanadium compounds were also synthesized and characterized, with applications either as prospective therapeutic drugs or as homogeneous or heterogenized catalysts for the production of fine chemicals. The developments made are described also considering the international context of the evolution of the knowledge in the chemistry and bioinorganic chemistry of vanadium compounds during the last 30years. This article was compiled based on the Vanadis Award presentation at the 9th International Vanadium Symposium. PMID:25843361

  11. International Year of Freshwater 2003

    NSDL National Science Digital Library

    2003-01-01

    Near the conclusion of the year 2000, the United Nations General Assembly created a resolution to proclaim 2002 as the International Year of Freshwater. Given the importance of freshwater to all human, plant, and animal life, this designation seems altogether fitting and timely. As the resolution notes, it is hoped that many governments and political actors will use the year to increase awareness of the importance of sustainable freshwater use, management, and protection. To this end, this helpful Web site provides a host of online resources designed to educate the web-browsing public about various events related to this overriding theme, along with presenting an online library of publications about freshwater. Visitors can read the online newsletter, Splash, along with browsing a water library, organized by themes (such as water and society and ecosystems), and geographic regions. Another compelling feature are the water proverbs taken from a number of areas, including the Middle East and Latin America. Given the global mission of the site it is refreshing to note that many of the materials are also available in French and Spanish. [KMG

  12. The International Polar Year, 2007-2008, an opportunity to focus on infectious diseases in Arctic regions.

    PubMed

    Parkinson, Alan J

    2008-01-01

    On 3 occasions over the past 125 years, scientists from around the world have worked together to organize scientific and exploration activities in polar regions (www.ipy.org). The first International Polar Year (IPY) in 1881-1884 marked the first major coordinated international scientific initiative to collect standardized meteorological and geophysical data in polar regions. Fifteen expeditions led by 12 nations amassed a large amount of data, but the scientific value was diminished by disjointed publication efforts and lack of long-term institutional commitment; lessons were learned and corrected in subsequent polar years. The second IPY began in 1932. Forty-four nations led expeditions in the Arctic and Antarctic, resulting in greater understanding of the aurora, magnetism, and meteorology. Air and marine navigation, radio operations, and weather forecasting were greatly improved as a result. The third IPY, in 1957-58, was renamed the International Geophysical Year and capitalized on technologic advances developed during World War II. Technologic and scientific momentum was redirected toward research, particularly to studies of the upper atmosphere, a legacy that continues to the present day. Notable achievements included launching the first satellite, measurement of atmospheric greenhouse gases, delineating the system of mid-ocean ridges, and confirming the theory of plate tectonics. PMID:18258069

  13. AIDS epidemiology: the past ten years, the next ten years.

    PubMed

    Crocchiolo, P R

    1991-01-01

    This article assesses the current seroprevalence of HIV worldwide, examines the patterns of infection over the past 10 years, and discusses the future impact of HIV. According to the World Health Organization (WHO), 8 million people have become infected with HIV since the early 1980s. As of November 1990, WHO estimates that some 800,000 people have developed AIDS. 54% of the HIV infections have occurred in Africa, 35% in the Americas, and 8% in Western Europe. The main HIV transmission routes are: 1) sexual intercourse with an infected partner (accounting for 75% of all infections); 2) HIV-infected blood or blood products, which include blood transfusions (5%), IV drug use (10%), and other needle (0.1%); and 3) perinatal transmission from infected mother to infant (10%). The article describes the 3 patterns of HIV infection so far: 1) In industrialized countries and in Latin America, HIV infections appeared in the early 1980s among homosexual men or IV drug users and then spread to the heterosexual population; 2) In Eastern and Central Africa, where heterosexual sex has been the main transmission route, infections began in the late 1970s; 3) In the rest of the world, HIV was not introduced until the mid-1980s, and because of the low prevalence rate, the main transmission route has not yet been determined. By the year 2000, WHO expects some 15-20 million HIV infections among adults and some 5-6 million AIDS cases among adults. In some industrialized countries, AIDS could become the leading cause of death among 20-40 year olds during the 1990s. At the same time, AIDS will have a devastating effect on sub-Saharan Africa's urban population, which will see a great increase in child mortality rates and in the number of orphaned children. PMID:12284242

  14. Epidemiological Follow-up 15 Years after the Breast Cancer Scandal in Essen

    PubMed Central

    Hauth, E. A. M.; Berkemeyer, S.; Jaeger, H.; Forsting, M.; Hoffmann, B.; Jöckel, K.-H.

    2012-01-01

    Purpose: In the years 1993–1996 a number of presumably false-positive breast cancer diagnoses were made by a pathologist in Essen. A follow-up, undertaken 15 years later, investigated how many women had tumour recurrence and/or metastasis or had died from breast cancer. Material and Methods: A total of 151 (68?%) out of 222 women could be traced. One hundred and forty-seven (66.2?%) of the 222 women were alive. The observed survival rate, number of recurrences and/or metastases, and number of deaths from breast cancer were compared with data from the Munich Tumour Registry. The number of breast cancer cases among daughters of the affected women was ascertained. Results: The total observed survival rate at follow-up after 15 years was 93?%, a much higher figure than the survival rate of 45?% given by the Munich Tumour Registry. Recurrence and/or metastasis or death from breast cancer occurred in 9/222 cases (4.1?%). The incidence for these events calculated according to data from the Munich Tumour Registry is 13?%. Two daughters (2.2?%) out of a total of 90 were diagnosed with breast cancer whereas, according to the German Cancer Research Centre, the expected rate would have been between 5 and 10?%. Conclusions: The results of our follow-up after 15 years show that more women survived than expected and that the number of recurrences and/or metastases and deaths due to breast cancer was lower than expected. Fewer daughters of affected women were diagnosed with breast cancer than expected. These results support our suspicion that not all women diagnosed with breast cancer by a pathologist in Essen actually had breast cancer. PMID:25284840

  15. CTIO: The Next 50 Years

    NASA Astrophysics Data System (ADS)

    Smith, R. C.

    2015-05-01

    After 50 years of solid scientific productivity, CTIO has established a strong reputation as a world-leading international observatory. The next 50 years are filled with opportunities to build on this foundation, continuing to put CTIO at the forefront of astronomy. In the near term (the next 10 years) we will be taking advantage of the power of the Dark Energy Camera (DECam) to map the southern skies, both as part of Dark Energy Survey (DES) and as part of a wide variety of community projects spanning scientific areas from near-earth asteroids to the most distant gravitationally-lensed galaxies. In addition, we will add new spectroscopic capabilities, both in the optical, with COSMOS, and the near-infrared, with TripleSpec. With the combination of these new facilities with those coming to SOAR, including SAM, SIFS, and STELES, CTIO will provide a highly-efficient suite of capabilities to support astronomers for this decade. And of course we will be preparing for the next decade, which will be the decade of the Large Synoptic Survey Telescope (LSST). CTIO continues to play a central role in supporting the development of LSST during its construction on Cerro Pachón over the next 5 years. However, even more important will be the role CTIO facilities will play in the science of the LSST era. While astronomers will certainly be able to do many new and innovative projects with only the LSST database, a significant fraction of the scientific potential of LSST relies upon optical and infrared followup. The telescopes and instruments of CTIO, from the tenant 1m telescopes to the instruments on the Blanco and SOAR, will be a critical part of the newly rebalanced observing "system". Given that cutting-edge instrumentation can take 5-10 years to move from conception to first light, today is not too early to decide which new instruments we must start developing now in order to fulfill the needs of the community in the next decade.

  16. Investigating First Year Education Students' Stress Level

    ERIC Educational Resources Information Center

    Geng, Gretchen; Midford, Richard

    2015-01-01

    This paper investigated the stress levels of first-year education students who undertake teaching practicum and theory units during their first year of teacher education program. First, 139 first-year and 143 other years' education students completed the PSS-10 scale, which measures perceived level of stress. Then, 147 first-year education…

  17. Fall Semester Year 1 required coursework for

    E-print Network

    Thomas, David D.

    Year One Year Two Year Three Fall Semester Year 1 required coursework for PharmD, 18 credits PMBA 2100, 2 credits PMBA 2200, 2 credits Total semester credits = 20 Fall Semester Year 2 required coursework for PharmD, 18.5 credits MBA 8211, 2 credits PMBA 2400, 2 credits Total semester credits = 22

  18. Vancomycin Revisited – 60 Years Later

    PubMed Central

    Rubinstein, Ethan; Keynan, Yoav

    2014-01-01

    Vancomycin is one of the older antibiotics that has been now in clinical use close to 60?years. Earlier on, vancomycin was associated with many side effects including vestibular and renal, most likely due to impurities contained in early vancomycin lots. Over the years, the impurities have been removed and the compound has now far less vestibular adverse effects, but still possesses renal toxicity if administered at higher doses rendering trough serum levels of >15?mcg/mL or if administered for prolonged periods of time. Vancomycin is effective against most Gram-positive cocci and bacilli with the exception of rare organisms as well as enterococci that became vancomycin resistant, mostly Enterococcus faecium. The major use of vancomycin today is for infections caused by methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE) and amoxicillin-resistant enterococci. In its oral form, vancomycin is used to treat diarrhea caused by Clsotridium difficile. With S. aureus, there are only a handful of vancomycin-resistant strains. Nevertheless, a “vancomycin creep” that is slow upward trending of vancomycin MIC from <1?mcg/mL to higher values has been noted in several parts of the world, but not globally, and strains that have MIC’s of 1.5–2?mcg/mL are associated with high therapeutic failure rates. This phenomenon has also been recently recognized in methicillin-susceptible S. aureus (MSSA). While vancomycin is relatively a safe agent adverse events include the “red man” syndrome, allergic reactions, and various bone marrow effects as well as nephrotoxicity. Vancomycin has been a very important tool in our therapeutic armamentarium that remained effective for many years, it is likely remain effective as long as resistance to vancomycin remains controlled. PMID:25401098

  19. Fifty years with nuclear fission

    SciTech Connect

    Behrens, J.W.; Carlson, A.D. (eds.) (National Institute of Standards and Technology, Gaithersburg, MD (United States))

    1989-01-01

    The news of the discovery of nuclear fission, by Otto Hahn and Fritz Strassmann in Germany, was brought to the United States by Niels Bohr in January 1939. Since its discovery, the United States, and the world for that matter, has never been the same. It therefore seemed appropriate to acknowledge the fifieth anniversary of its discovery by holding a topical meeting entitled, Fifty Years with Nuclear Fission,'' in the United States during the year 1989. The objective of the meeting was to bring together pioneers of the nuclear industry and other scientists and engineers to report on reminiscences of the past and on the more recent development in fission science and technology. The conference highlighted the early pioneers of the nuclear industry by dedicated a full day (April 26), consisting of two plenary sessions, at the National Academy of Sciences (NAS) in Washington, DC. More recent developments in fission science and technology in addition to historical reflections were topics for two fully days of sessions (April 27 and 28) at the main site of the NIST in Gaithersburg, Maryland. The wide range of topics covered in this Volume 1 by this topical meeting included plenary invited, and contributed sessions entitled: Preclude to the First Chain Reaction -- 1932 to 1942; Early Fission Research -- Nuclear Structure and Spontaneous Fission; 50 Years of Fission, Science, and Technology; Nuclear Reactors, Secure Energy for the Future; Reactors 1; Fission Science 1; Safeguards and Space Applications; Fission Data; Nuclear Fission -- Its Various Aspects; Theory and Experiments in Support of Theory; Reactors and Safeguards; and General Research, Instrumentation, and By-Product. The individual papers have been cataloged separately.

  20. AFI's 100 Years 100 Laughs

    NSDL National Science Digital Library

    On June 13, the American Film Institute (AFI) revealed its list of the 100 funniest movies as chosen by "leaders of the entertainment community" from a list of 500 nominated movies. At this site, users can view both the top 100 list and the 500 nominated films. Each listing links to a short description with principal cast, director, producer, and screenwriter. The list of the 500 nominated films may also be keyword searched by title, cast, director, producer, screenwriter, year, or description. Users can also make their own top ten list and submit it to the site.

  1. Fiscal Year 2009 Revegetation Assessment

    SciTech Connect

    Michael Lewis

    2009-10-01

    This report summarizes the Fiscal Year 2009 Revegetation Assessment by Battelle Energy Alliance, LLC. This assessment was conducted to supplement documentation related to the Storm Water Pollution Prevention Plan for Construction Activities and to ensure that disturbed vegetation and soil at various locations are being restored. This report provides the following information for each site being monitored by the Idaho National Laboratory Environmental Support and Services: • Summary of each site • Assessment of vegetation status and site stabilization at each location • Recommendation(s) for each site.

  2. Fuel ethanol after 25 years.

    PubMed

    Wheals, A E; Basso, L C; Alves, D M; Amorim, H V

    1999-12-01

    After 25 years, Brazil and North America are still the only two regions that produce large quantities of fuel ethanol, from sugar cane and maize, respectively. The efficiency of ethanol production has steadily increased and valuable co-products are produced, but only tax credits make fuel ethanol commercially viable because oil prices are at an all-time low. The original motivation for fuel-ethanol production was to become more independent of oil imports; now, the emphasis is on its use as an oxygenated gasoline additive. There will only be sufficient, low-cost ethanol if lignocellulose feedstock is also used. PMID:10557161

  3. Exercise During the Childbearing Year

    PubMed Central

    Hammer, Roger L.; Perkins, Jan; Parr, Richard

    2000-01-01

    Many women wish to continue to pursue an active lifestyle during pregnancy, while the pregnancy itself may provide the motivation for other more sedentary women to begin an exercise program for the sake of improved health/fitness. Also, female competitive athletes, upon becoming pregnant, may wish to continue sports performance and require careful monitoring to assure maternal-fetal safety. This review is designed to assist the perinatal educator who is in the position to advise the pregnant patient on the risks and benefits of physical activity during the childbearing year and provide suggestions for developing individualized exercise programs. PMID:17273187

  4. Systematic analysis and experiment of inductive coupling and induced voltage for inductively coupled wireless implantable neurostimulator application

    Microsoft Academic Search

    Ning Xue; Sung-Hoon Cho; Sung-Pil Chang; Jeong-Bong Lee

    2012-01-01

    The main strategy for wireless power transfer to implantable devices is to use inductive coupling technology. The induced voltage of implanted devices highly depends on factors such as mutual inductance between the external transmitter coil and the receiver coil, quality factor of the receiver circuit and operation frequency. In this paper, the mutual inductance under a variety of geometries of

  5. Teenagers (15-17 years of age)

    MedlinePLUS

    ... message, please visit this page: About CDC.gov . Child Development Facts Developmental Screening Screening for Professionals Positive Parenting Tips Infants (0-1 year) Toddlers (1-2 years) Toddlers (2-3 years) Preschoolers ( ...

  6. Middle Childhood (6-8 Years Old)

    MedlinePLUS

    ... message, please visit this page: About CDC.gov . Child Development Facts Developmental Screening Screening for Professionals Positive Parenting Tips Infants (0-1 year) Toddlers (1-2 years) Toddlers (2-3 years) Preschoolers ( ...

  7. Fifty years with nuclear fission

    SciTech Connect

    Behrens, J.W.; Carlson, A.D. (eds.) (National Institute of Standards and Technology, Gaithersburg, MD (United States))

    1989-01-01

    The news of the discovery of nucler fission, by Otto Hahn and Fritz Strassmann in Germany, was brought to the United States by Niels Bohr in January 1939. Since its discovery, the United States, and the world for that matter, has never been the same. It therefore seemed appropriate to acknowledge the fiftieth anniversary of its discovery by holding a topical meeting entitled, Fifty years with nuclear fission,'' in the United States during the year 1989. The objective of the meeting was to bring together pioneers of the nuclear industry and other scientists and engineers to report on reminiscences of the past and on the more recent developments in fission science and technology. The conference highlighted the early pioneers of the nuclear industry by dedicating a full day (April 26), consisting of two plenary sessions, at the National Academy of Sciences (NAS) in Washington, DC. More recent developments in fission science and technology in addition to historical reflections were topics for two full days of sessions (April 27 and 28) at the main sites of the NIST in Gaithersburg, Maryland. The wide range of topics covered by Volume 2 of this topical meeting included plenary invited, and contributed sessions entitled, Nuclear fission -- a prospective; reactors II; fission science II; medical and industrial applications by by-products; reactors and safeguards; general research, instrumentation, and by-products; and fission data, astrophysics, and space applications. The individual papers have been cataloged separately.

  8. International Heliophysical Year: European Activities

    NASA Astrophysics Data System (ADS)

    Briand, C.

    2007-08-01

    The First European General Assembly of the "International Heliophysical Year" (IHY) took place at the headquarters of the Centre Nationial de la Recherche Scientifique (CNRS) in Paris, France, 10-13 January 2006. There were 113 participants representing 27 nations. The science concerned with the International Heliophysical Year programme was first illustrated. Then, the status of current instruments as well as practical information on the campaign management policy was given. Twenty European National Coordinators described the progress of their IHY activities. Representatives from Egypt, Angola and the coordinator of the Balkan, Black and Caspian Sea Region also reported on the progress of IHY activities in their respective regions. People from the IHY Secretariat provided a summary of the global IHY efforts including the United Nations Basic Space Sciences Program. In the education and public outreach front, a variety of activities have been planned: TV and radio shows, board games on space weather, specific programmes for schools and universities, workshops for teachers are some of the actions that were presented by the delegates. Beyond of these national and individual initiatives, specific activities requiring European coordination were discussed. This paper provides an extended summary of the main talks and discussions that held during the meeting.

  9. International Year of Rice 2004

    NSDL National Science Digital Library

    The importance of rice as a basic foodstuff to over half of the world's populations can not be underestimated, and it was with this fact in mind that the International Rice Research Institute first developed the idea for the International Year of Rice in 1999. Working in tandem with the United Nations General Assembly, the Institute set up a number of partnerships, conferences, lectures, and research agendas to take place throughout the year 2004 and beyond. The site contains links to numerous important papers, such as the collection available here from the recent conference titled Rice in Global Markets and Sustainable Production Systems, which was held in Rome. Beyond various scholarly and policy-oriented resources, visitors can learn about the rice photography contest, submit recipes to a forthcoming rice-themed cookbook, and explore a kids section that offers some basic facts about rice, along with a short quiz. The site is available in a number of different languages, including Italian, Spanish, French, Arabic, and Japanese.

  10. [HTLV research 30th year].

    PubMed

    Koyanagi, Yoshio

    2011-12-01

    This year is 30th year since HTLV was first reported as a causative agent for ATL. From a series of extensive studies especially by Japanese researches, a variety of information is now available, such as characteristics of the virus, regulation of viral and/or cell gene expression by HTLV-encoded protein Tax and Rex, the pathway of activation machinery on cell growth, the mechanism of cell-to-cell transmission, and prevalence of HTLV carries. However, it remains unsolved how HIV-1 invades and enters into human, how HIV-1 replicates in vivo, how the tumor cells are selected during course of infection, and which cellular molecules contribute disease onset and progression. It was thought the mechanism of HTLV-related diseases, ATL and HAM, would be quickly revealed earlier time after HTLV discovery since the HTLV-related diseases show unique characteristics. Nevertheless, we do not have yet satisfied knowledge of the pathogenesis mechanism as well as the treatment. I describe the history and perspective. PMID:22916564

  11. Year 2000 (Y2K) News Clippings

    NSDL National Science Digital Library

    The Year 2000 Archives and news clippings site contains many useful articles on the Year 2000 problem. The Year 2000 problem is caused by the fact that most computer systems only recognize the last two digits of a year. As a result, when the year 2000 comes around, it will be stored as year "00." This will give rise to mathematical and logical errors in computer systems resulting in incorrect results or even system failures.

  12. Respiratory Syncytial Virus Bronchiolitis in Children up to 5 Years of Age in Spain: Epidemiology and Comorbidities: An Observational Study.

    PubMed

    Gil-Prieto, Ruth; Gonzalez-Escalada, Alba; Marín-García, Patricia; Gallardo-Pino, Carmen; Gil-de-Miguel, Angel

    2015-05-01

    This epidemiological survey in Spain estimates the burden of respiratory syncytial virus (RSV) infection in children up to 5 year of age during a 15-year period (1997-2011).Observational retrospective survey was conducted by reviewing data of the National Surveillance System for Hospital Data, including >98% of Spanish hospitals. All hospitalizations related to RSV infection for children up to 5 years, reported during 1997-2011 period, were analyzed. Codes were selected by using the International Classification of Diseases 9th Clinical Modification 466.0-466.19, 480.1, and 079.6.A total of 326,175 and 286,007 hospital discharges for children up to 5 and 2 years of age were reported during the study period. The annual incidence was 1072 and 2413 patients per 100,000, respectively. The average length of hospital stay was 5.7 (standard deviation 8.2) days. Four hundred forty-six deaths were reported; of those, 403 occurred in children <2 years and 355 (80%) occurred in children <12 months of age.Hospitalization and mortality rates were significantly higher in boys and decrease significantly with age. The higher rate of hospitalization and mortality rates were found in the first year of life.Annual average cost for National Health Care System was &OV0556; 47 M with a mean hospitalization cost of &OV0556;2162. The average length of hospitalization and costs were significantly higher in high-risk children.RSV infections in children up to 5 year of age still pose a significant health threat in Spain, especially in the infants. The development of preventive, diagnostic, and therapeutic guidelines focused in children with comorbidities may help reduce the hospital and economic burden of the disease. PMID:26020386

  13. 7 CFR 1205.320 - Marketing year.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Definitions § 1205.320 Marketing year. Marketing year means a consecutive...

  14. 7 CFR 1205.320 - Marketing year.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Definitions § 1205.320 Marketing year. Marketing year means a consecutive...

  15. 7 CFR 1205.320 - Marketing year.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Definitions § 1205.320 Marketing year. Marketing year means a consecutive...

  16. 7 CFR 1205.320 - Marketing year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Definitions § 1205.320 Marketing year. Marketing year means a consecutive...

  17. ADS on WWW: Doubling Yearly for Five Years

    NASA Astrophysics Data System (ADS)

    Kurtz, M. J.; Eichhorn, G.; Accomazzi, A.; Grant, C. S.; Murray, S. S.

    1998-12-01

    It is now five years since the NASA ADS Abstract Service became available on the World Wide Web, in late winter of 1994. Following the explosive growth of the service (when compared with the old propriatory network access system) in the early months of WWW service, ADS growth has settled to doubling yearly. Currently ADS users make 440,000 queries per month, and receive 8,000,000 bibliographic references and 70,000 full-text articles, as well as abstracts, citation histories, links to data, and links to other data centers. Of the 70,000 full-text articles accessed through ADS each month, already 30% are via pointers to the electronic journals. This number is certain to increase. It is difficult to determine the exact number of ADS users. We track usage by the number of unique ``cookies'' which access ADS, and by the number of unique IP addresses. There are difficulties with each technique. In addition many non-astronomers find ADS through portal sites like Yahoo, which skews the statistics. 10,000 unique cookies access the full-text articles each month, 17,000 make queries, and 30,000 visit the site. 91% of full-text users have cookies, but only 65% of site visitors. From another perspective the number of IP addresses from a single typical research site (STScI) which access the full-text data is within 5% of the number of unique cookies assiociated with full-text use from stsci.edu, and also within 5% of the number of AAS members listing an STScI address. The number of unique IP addresses from STScI which make any sort of query to ADS is 40% higher than this. Those who access the full-text average one article per day, those who make queries average two per day. We believe nearly all active astronomy researchers, as well as students and affiliated professionals use ADS on a regular basis.

  18. Twenty Years of Tevatron Operation

    SciTech Connect

    Theilacker, J.C. [Fermi National Accelerator Laboratory, Batavia, IL, 60510 (United States)

    2004-06-23

    The superconducting Tevatron accelerator at Fermi National Accelerator Laboratory (Fermilab) has surpassed twenty years of operation. The Tevatron is still the highest energy particle accelerator in the world and will remain so until the commissioning of the LHC in Europe later this decade. The Tevatron has operated in a Fixed Target mode, accelerating a proton beam into stationary targets/detectors, as well as a Colliding Beam mode, continuously colliding counter rotating beams of protons and antiprotons. Upon completion, the Tevatron cryogenic system became the world's largest helium refrigeration system. In 1993, the Tevatron cryogenic system was given the designation of International Historic Mechanical Engineering Landmark by the American Society of Mechanical Engineers. The operational history, experiences and statistics of the Tevatron, with an emphasis on the cryogenic system, is presented. Improvements, upgrades and current challenges of the cryogenic system are discussed.

  19. Civil partnerships five years on.

    PubMed

    Ross, Helen; Gask, Karen; Berrington, Ann

    2011-01-01

    The Civil Partnership Act 2004, which came into force in December 2005 allowing same-sex couples in the UK to register their relationship for the first time, celebrated its fifth anniversary in December 2010. This article examines civil partnership in England and Wales, five years on from its introduction. The characteristics of those forming civil partnerships between 2005 and 2010 including age, sex and previous marital/civil partnership status are examined. These are then compared with the characteristics of those marrying over the same period. Further comparisons are also made between civil partnership dissolutions and divorce. The article presents estimates of the number of people currently in civil partnerships and children of civil partners. Finally the article examines attitudes towards same-sex and civil partner couples both in the UK and in other countries across Europe. PMID:21987019

  20. [50 years of molecular biology].

    PubMed

    Trgovcevi?, Z

    1994-01-01

    In 1865, Johann Gregor Mendel laid the mathematical foundation of the science of genetics. His "elements of heredity" (later called genes) were postulated as pure algebraic units. At about the same time (1868), Friedrich Miescher extracted a gelationous substance from the nuclei of white blood cells found in pus. This substance was called nuclein; later it became known as nucleic acid. Fifty years ago, Oswald T. Avery and his colleagues showed that one type of nucleic acid--DNA mediates genetic transformation in pneumococci. This was the first demonstration that Miescher's nuclein is the repository of Mendel's hypothetical elements of heredity. The genes thus "materialized". Although not recognized by contemporaries, Avery's discovery may be considered as a landmark in the history of biology. The molecular era of genetics and biology has begun. Other events associated with the beginning of this new era (bacteriophage research, work on nutritional mutants in Neurospora) are also described in the present review. PMID:7715413

  1. [Pediatric aids, 30 years later].

    PubMed

    Blanche, S; Dollfus, C; Faye, A; Rouzioux, C; Mandelbrot, L; Tubiana, R; Warszawski, J

    2013-08-01

    Thirty years after the first descriptions of AIDS in children in May 1983, the risk of viral transmission from mother to child has been reduced to almost zero and the disease in infected children has become an asymptomatic condition, stable in the long-term, thanks to antiretroviral drugs. Unbelievable though it may have seemed until the mid-1990s, children infected during the perinatal period are now growing up to be adults in a chronic, stable, asymptomatic medical condition with often satisfactory personal, family, and social lives. The French perinatal epidemiological cohort, which was set up in 1984 and has included more than 18,000 mother-child pairs to date, traces the steps in this extraordinary revolution in the prevention and treatment of HIV-1 infection in children. PMID:23850051

  2. Two-year outcome with the AperFix system for ACL reconstruction.

    PubMed

    Uribe, John W; Arango, Dillon; Frank, Jeremy; Kiebzak, Gary M

    2013-02-01

    The purpose of the study was to assess the fixation durability of the AperFix System (Cayenne Medical, Inc, Scottsdale, Arizona) used in arthroscopic reconstruction of the anterior cruciate ligament. The AperFix System consists of a femoral and tibial component designed to secure either allograft or autograft. The outcomes of 185 knees (180 patients) were retrospectively reviewed at a minimum of 2 years postoperatively. Mean age at surgery was 31±12 years (range, 16-68 years). Of these, a convenience sample was seen prospectively to obtain radiographs and to assess functional status. No cases occurred of fixation failure involving loss of graft positioning or pullout. No patients required revision anterior cruciate ligament reconstruction. In 2 knees, the tip of the central fixation pin had to be modified as a result of hardware prominence and soft tissue irritation at 434 and 159 days postoperatively, respectively. In 4 knees, tibial screw removal occurred secondary to local discomfort (mean, 239 days; range, 105-371 days). No other recurring adverse events or problems associated with the implants were identified. Forty-four patients were evaluated prospectively at a mean follow-up of 32±7 months. Lysholm scores and patient satisfaction scores were positively and significantly correlated with Tegner activity scores (r=0.61; P<.0001). Eighty-two (82%) patients had a KT-1000 (Medmetric Corp, San Diego, California) side-to-side difference of less than 3 mm (average, 0.4 mm). No indications of femoral device migration existed when comparing follow-up and immediate postoperative radiographs. The AperFix System provides durable femoral aperture fixation during anterior cruciate ligament reconstruction with excellent clinical outcome scores and a low complication rate. PMID:23379927

  3. Atrial septal defects: Pattern, clinical profile, surgical techniques and outcome at Innova heart hospital: A 4-year review

    PubMed Central

    Adiele, Daberechi K.; Chinawa, Josephat M.; Arodiwe, Ijeoma O.; Gouthami, V.; Murthy, K. S.; Eze, John C.; Obidike, Egbuna. O.; Ujunwa, Fortune A.

    2014-01-01

    Background: Atrial septal defect (ASD) is a congenital heart defect that leads to shunting of blood between left and right atria. It may be asymptomatic and sometimes may present with heart failure. Surgical repair is definitive, but currently non-surgical procedure is used to close the defect. Materials and Methods: It is a retrospective study of patients who underwent transcatheter closure of ASD at Innova Heart Hospital, Hyderabad, India. Echocardiography was repeated at intervals of 24 hours, then at 1, 3 and 6 months after the procedure to assess complications. The morphological characteristics of the ASD, including its diameter, location, shape and the width of surrounding septal margins, were also evaluated. Results: From April 2007 to June 2011, 69 consecutive children (29 males, 40 females) with a median age of 9.0 years (range = 3.2–19 years) registered with diagnosis of ASD. The median weight was 31.5 kg (range = 7.5–39.0 kg). Five patients (7.2%) were young children aged 3–5 years. Forty-four (63.8%) of these children presented with symptoms of heart failure, whereas 47 (68.1%) of the cases repaired with device were large-sized ASD. The most common interventional procedures done were Searcare Heart® and Amplatzer® technique with a highest success rate obtained in 2010. Conclusions: ASD is a common congenital heart disease with a high success rate for those who undergo intervention. PMID:24791045

  4. Long term effects of one or two doses of hepatitis B vaccine in adults after five years.

    PubMed

    Ghorbani, Gholam Ali; Alavian, Seyed Moaied; Ghadimi, Hamid Reza

    2008-02-15

    The aim of this study is to evaluate hepatitis B vaccine protection in those adults who have taken one or two does of vaccine before. It was a retrospective cross sectional study was conducted on fifty-six military personnel in Tehran, Iran in the spring 2007. Demographic data such as age, marital status, education level, number of vaccine doses injected and, type of vaccine and date of last vaccination was collected. Their serum was tested for HBs Ab, HBc Ab and HBs Ag and finally the results were analyzed by SPSS software. All individuals were male with the mean age of 33.9+/-8.9 years. Twelve individuals who had only received one dose of injected vaccine had no antibody against HBsAg and no protection against hepatitis B virus. Of forty-four individuals that had received two doses of injected vaccine, 27 persons (61.4%) were protected and had serum HBsAb more than 10 MIU mL(-1). In conclusion one dose of HBV vaccine cannot produce immunity for five years but two doses of HBV vaccine can produce immunity for five years. However, HBsAb should be tested to make sure of immunity. PMID:18817145

  5. Surgery versus prolonged conservative treatment for sciatica: 5-year results of a randomised controlled trial

    PubMed Central

    Lequin, Michiel B; Verbaan, Dagmar; Jacobs, Wilco C H; Brand, Ronald; Bouma, Gerrit J; Vandertop, William P; Peul, Wilco C

    2013-01-01

    Objective This study describes the 5?years’ results of the Sciatica trial focused on pain, disability, (un)satisfactory recovery and predictors for unsatisfactory recovery. Design A randomised controlled trial. Setting Nine Dutch hospitals. Participants Five years’ follow-up data from 231 of 283 patients (82%) were collected. Intervention Early surgery or an intended 6?months of conservative treatment. Main outcome measures Scores from Roland disability questionnaire, visual analogue scale (VAS) for leg and back pain and a Likert self-rating scale of global perceived recovery were analysed. Results There were no significant differences between groups on the 5?years’ primary outcome scores. Despite at least 6?months of conservative treatment 46% of the conservatively allocated patients were treated surgically because of severe leg pain and disability. Forty-nine (21%) patients had an unsatisfactory recovery at 5?years and the recovery pattern showed that there was a variable group of 66 patients (31%) with at least one unsatisfactory outcome at 1, 2 or 5?years of follow-up. Multivariate logistic regression showed that age (>40; OR 2.42 (95% CI 1.16 to 5.02)), severity of leg pain (VAS >70; OR 3.32 (95% CI 1.69 to 6.54)) and the Mc Gill affective score (score >3; OR 6.23 (95% CI 2.23 to 17.38)) were the only significant predictors for an unsatisfactory outcome at 5?years. Conclusions In the long term, 8% of the patients with sciatica never showed any recovery and in at least 23%, sciatica appears to result in ongoing complaints, which fluctuate over time, irrespective of treatment. Prolonged conservative care might give patients a fair chance for pain and disability to resolve without surgery, but with the risk to receive delayed surgery after prolonged suffering of sciatica. Age above 40?years, severe leg pain at baseline and a higher affective Mc Gill pain score were predictors for unsatisfactory recovery. Trial Registry ISRCT No 26872154. PMID:23793663

  6. Cementless Metasul metal-on-metal total hip arthroplasties at 13 years.

    PubMed

    Randelli, Filippo; Banci, Lorenzo; D'Anna, Alessandro; Visentin, Ornella; Randelli, Gianni

    2012-02-01

    Second-generation metal-on-metal bearings have been used since the late 1980s as alternative bearings to eliminate aseptic loosening due to polyethylene wear. The aim of the present study was to evaluate the long-term results of a series of Metasul (Zimmer GmbH, Winterthur, Switzerland) metal-on-metal total hip arthroplasty (THA). One hundred forty-nine cementless THAs with a 28-mm Metasul articulation were performed in 111 consecutive patients. The results were retrospectively reviewed at 13 years postoperatively. Clinical and radiographic evaluations and implant survivorship were performed. Seven hips (4.7%) were revised. The overall survivorship with revision for any reason as the end point was 0.94. The average Harris hip score was 91.4. Expansive osteolysis was found adjacent to the stem in 4 hips. Metal wear-related aseptic loosening was not the major reason for failure in our Metasul metal-on-metal THAs. Recurrent dislocation was the main reason for revision in our series. PMID:21621954

  7. Effect of Parental Bereavement on Health Risk Behaviors in Youth: A 3-Year Follow-up

    PubMed Central

    Hamdan, Sami; Mazariegos, David; Melhem, Nadine M.; Porta, Giovanna; Payne, Monica Walker; Brent, David A.

    2013-01-01

    Objective To examine the course of health risk behaviors (HRBs) during a 3-year period after a parent’s death in bereaved youth compared with nonbereaved youth (control subjects). Design A longitudinal population-based study. Setting Bereaved families were recruited through coroner records and by advertisement. Control families were recruited using random-digit dialing and by advertisement. Participants Two hundred forty parentally bereaved offspring were compared with 183 nonbereaved control offspring. Main Exposure Sudden parental death due to accident, suicide, or sudden disease-related (natural) death. Main Outcome Measures The sum of the total number of HRBs at a clinically significant frequency threshold assessed 9, 21, and 33 months after the parent’s death. Results The bereaved group showed a higher number of HRBs over time compared with the nonbereaved group (univariate effect sizes, 0.22–0.52; P<.04), even after taking into account correlates of bereavement and of HRBs, such as youth aggression, as well as antisocial and anxiety disorders of the deceased parent. Conclusions Parental bereavement is associated with higher HRBs in youth over time, even after controlling for other covariates associated with bereavement and HRBs. Clinicians should be aware that bereaved youth may be vulnerable to HRBs. Further work is warranted on interventions to attenuate the negative effect of bereavement on HRBs. PMID:22393180

  8. Predictors of Institutionalization of Dementia Patients in Mild and Moderate Stages: A 4-Year Prospective Analysis

    PubMed Central

    Eska, Kathrin; Graessel, Elmar; Donath, Carolin; Schwarzkopf, Larissa; Lauterberg, Joerg; Holle, Rolf

    2013-01-01

    Background Institutionalization is the most important milestone in the care of dementia patients. This study was aimed at identifying relevant predictors of institutionalization in a broad empirical context and interpreting them on the basis of the predictor model proposed by Luppa et al. [Dement Geriatr Cogn Disord 2008;26:65-78]. Methods At the start of this study, 357 patients with mild to moderate dementia were examined by their general practitioners, and a telephone interview was conducted with their caregivers. Four years later, the outcomes ‘institutionalization’ and ‘death’ were determined from health insurance data. Forty-one variables were examined for their predictive influence by univariate and multivariate Cox regression. Results The risk of institutionalization increased significantly (p ? 0.05) with older ages of patients [hazard ratio (HR) = 1.05] and caregivers (HR = 1.03), a higher educational level of the caregiver (HR = 1.83), greater use of community health services (HR = 1.59), greater caregiver burden (HR = 1.02), and when the caregiver and patient lived apart (HR = 1.97). Conclusion The results show that there is a multifactorial influence on institutionalization of dementia patients by sociodemographic, health-related, and psychological aspects as well as the care situation, thus validating the predictor model by Luppa et al. [Dement Geriatr Cogn Disord 2008;26:65-78]. Caregiver burden was found to be the strongest predictor accessible to interventions. PMID:24348504

  9. One-year clinical evaluation of a Glass Carbomer fissure sealant, a preliminary study.

    PubMed

    Gorseta, K; Glavina, D; Borzabadi-Farahani, A; Van Duinen, R N; Skrinjaric, I; Hill, R G; Lynch, E

    2014-06-01

    Glass Carbomer is a new generation of restorative material developed from glass-ionomer cements with possibility of gradual mineralization into fluorapatite. The aim of this clinical trial was to investigate the retention of Glass Carbomer fissure sealant after 12 months, in comparison to a commonly used conventional resin-based sealant. Forty-eight teeth in 24 patients [mean (SD) = 8 (2.3) years] with well-delineated fissure morphology were randomly divided into two equal groups and sealed with Bis-GMA resin-based Helioseal F (group A, Ivoclar Vivadent, Liechtenstein) and Glass Carbomer (group B, Glass Carbomer Sealant, Glass Carbomer Products, Leiden, Netherlands) using the split mouth design. Materials were placed and set according to the manufacturer's instructions using a polymerization unit Bluephase 16i (Vivadent, Liechtenstein). Complete sealant retentions in both groups were 100% and 75% after 6 and 12 months of clinical service, respectively. There were there were no secondary caries lesions in both groups after 6 months; two new carious lesions were detected in both groups after 12 months. The Mann-Whitney U test revealed no significant difference between the two groups at both evaluations points (P > 0.05). Glass Carbomer material showed a similar retention rate when compared with a resin-based sealant. Future studies are required to examine the long-term performance of Glass Carbomer sealants. PMID:25134364

  10. 1st year Requirements 2nd year requirements 3rd year requirements 4th year requirements Course Grade Credits Course Grade Credits Course Grade Credits Course Grade Credits

    E-print Network

    Dyer, Bill

    Name: GID: Catalog: 1st year Requirements 2nd year requirements 3rd year requirements 4th year requirements Course Grade Credits Course Grade Credits Course Grade Credits Course Grade Credits ARCH 121IA Requirements Non ARCH Requirements Non ARCH Requirements Non ARCH Requirements Category Course Grade Credits

  11. FLY Program (Freshers' Leave Year Program)

    E-print Network

    Miyashita, Yasushi

    and values by themselves. Program overview This program is based on the gap year system of universitiesFLY Program (Freshers' Leave Year Program) The University of Tokyo introduces the new FLY Program (Freshers' Leave Year Program), starting from the 2013 academic year. This program enables undergraduate

  12. AMRA's golden years: 1979-1988.

    PubMed

    Buckland, A

    1988-10-01

    Ten years ago AMRA had a golden anniversary celebrating 50 years of existence. Today, in 1988, we have accumulated 60 years of service to our members, to health record science, to the world of allied health, and to the protection of patients' confidentiality rights. Inasmuch as the first years of AMRA were chronicled in articles appearing in Medical Record News, August 1978 and February 1979, this article will review only the golden years, the period following our 50th anniversary. PMID:10302852

  13. [Pediamécum: one year of experience].

    PubMed

    Piñeiro Pérez, R; Martínez Fernández-Llamazares, C; Calvo Rey, C; Piñeiro Pérez, A P; Criado Vega, E A; Bravo Acuña, J; Cabrera García, L; Mellado Peña, M J

    2014-10-01

    In 2011, the Spanish Association of Pediatrics decided to support the most ambitious project of its newly created Committee for Medicinal Products: Pediamécum. This is the first free on-line database with information on medicinal products for pediatric use in Spain. The web page http://pediamecum.es/ started on December 17 December 2012. One year later, Pediamécum includes 580 registered drugs. The website achieved more than one million page views by the end of 2013. Because of the first anniversary of Pediamécum, a survey was performed to request the feeling of users. Four hundred eighty-three responses were obtained. Ninety-five percent believed that it is easy to navigate through the web, and 74% said that their doubts about the use of medicines in children were always resolved. The overall rating of Pediamécum is 7.5/10. The aims of Pediamécum are being accomplished; which is reflected essentially due to it becoming a useful tool for all professionals who care for children in their daily clinical practice. PMID:24857432

  14. Thirteen years of pair production

    SciTech Connect

    Strayer, M.R.

    1994-12-31

    This talk surveys a thirteen-year collaboration with Chris Bottcher on various aspects of strong field electrodynamics. Most of the work centers on the atomic physics associated with the peripheral collisions of ultrarelativistic heavy atoms. The earliest, beginning in about 1979, dealt with the spontaneous emission of positrons from nuclear quasimolecules and touched briefly on the formation of axions as a possible explanation of the anomalous peaks in the spectrum. This work stimulated the extensive studies of particle production from coherent fields that laid the foundations for investigations of nuclear form factors, structure functions, and production mechanisms for the Higgs and other exotic particles. Chris conjectured that the strong fields that are present in these collisions would give rise to nonperturbative effects. Thus, during this time, Chris also worked to develop basis-spline collocation methods for solving dynamical relativistic fermions in super strong fields. This was perhaps one of the best of times for Chris; on these problems alone, he co-authored fifty articles with more than twenty different collaborators.

  15. Cloning: eight years after Dolly.

    PubMed

    Campbell, K H S; Alberio, R; Choi, I; Fisher, P; Kelly, R D W; Lee, J-H; Maalouf, W

    2005-08-01

    It is now 8 years since the birth of Dolly, the first animal produced by nuclear transfer using a donor cell population established from an adult animal. During this time, the technique of nuclear transfer has been successfully applied to a range of mammalian species for the production of offspring using a plethora of donor cell types derived from both foetal and adult tissues. In addition, when coupled with genetic manipulation of the donor cells, transgenic offspring have been produced with a range of genetic modifications including gene knockouts and gene knockings. Despite the apparent successes of the technology, the efficiency of development to live offspring has remained low and developmental abnormalities still occur. The objectives of this paper are to review some of the successes and failures of the nuclear transfer procedure since the production of Dolly. In particular, we will review the major steps in the procedure and discuss studies from our laboratory and others which have modified the procedure in ways which may impact on development. PMID:16008756

  16. The Year in Cognitive Neuroscience

    PubMed Central

    Fitch, W Tecumseh; Martins, Mauricio D

    2014-01-01

    Sixty years ago, Karl Lashley suggested that complex action sequences, from simple motor acts to language and music, are a fundamental but neglected aspect of neural function. Lashley demonstrated the inadequacy of then-standard models of associative chaining, positing a more flexible and generalized “syntax of action” necessary to encompass key aspects of language and music. He suggested that hierarchy in language and music builds upon a more basic sequential action system, and provided several concrete hypotheses about the nature of this system. Here, we review a diverse set of modern data concerning musical, linguistic, and other action processing, finding them largely consistent with an updated neuroanatomical version of Lashley's hypotheses. In particular, the lateral premotor cortex, including Broca's area, plays important roles in hierarchical processing in language, music, and at least some action sequences. Although the precise computational function of the lateral prefrontal regions in action syntax remains debated, Lashley's notion—that this cortical region implements a working-memory buffer or stack scannable by posterior and subcortical brain regions—is consistent with considerable experimental data. PMID:24697242

  17. Donor age and factors related to endothelial cell loss ten years after penetrating keratoplasty: Specular Microscopy Ancillary Study

    PubMed Central

    Lass, Jonathan H.; Benetz, Beth Ann; Gal, Robin L.; Kollman, Craig; Raghinaru, Dan; Dontchev, Mariya; Mannis, Mark J.; Holland, Edward J; Chow, Christopher; McCoy, Kristen; Price, Francis W.; Sugar, Alan; Verdier, David D.; Beck, Roy W.

    2013-01-01

    Objective To examine the effect of donor age and other perioperative factors on long term endothelial cell loss after penetrating keratoplasty (PKP) Design Multi-center, prospective, double-masked clinical trial Participants 176 participants from the Cornea Donor Study cohort who had not experienced graft failure 10 or more years after PKP for a moderate risk condition (principally Fuchs’ dystrophy or pseudophakic/aphakic corneal edema) Methods Corneas from donors 12 to 75 years old were assigned to participants using a randomized approach, without respect to recipient factors. Surgery and post-operative care were performed according to the surgeons’ usual routines. Images of the central endothelium were obtained preoperatively and at intervals for ten years postoperatively. Images were analyzed by a central image analysis reading center to determine endothelial cell density (ECD). Main Outcome Measure Endothelial cell density at 10 years Results Among study participants with a clear graft at 10 years, the 125 who received a cornea from a donor 12 to 65 years old experienced a median cell loss of 76%, resulting in a 10-year median ECD of 628 cells/mm2 (interquartile range, 522-850), whereas the 51 who received a cornea from a donor 66 to 75 years old experienced a cell loss of 79%, resulting in a median 10-year ECD of 550 cells/mm2 (interquartile range, 483-694) (P adjusted for baseline ECD=0.03). In addition to younger donor age, higher ECD values were significantly associated with higher baseline ECD (P<0.001) and larger donor tissue size (P<0.001). Forty-two (24%) of the 176 participants had an ECD below 500 cells/mm2 at 10 years and only 24 (14%) had an ECD above 1,000 cells/mm2. Conclusions Substantial cell loss occurs in eyes with a clear graft 10 years after PKP, with the rate of cell loss being slightly higher with older donor age. Higher pre-operative ECD and larger donor tissue size are associated with higher ECD at 10 years. Trial Registration NCT00006411 PMID:24246826

  18. Vannevar Bush: Fifty Years Later

    NASA Astrophysics Data System (ADS)

    Lagowski, J. J.

    1995-12-01

    It is ironic that the 50th anniversary year of Vannevar Bush's Report to President Truman entitled "Science the Endless Frontier", which put into motion the eminently successful current system of education of scientists in this country occurs at a time when serious questions are being asked about the usefulness of that very system. Bush viewed his proposal to establish a national research foundation (later to be called the National Science Foundation) as a "social compact." Judgment of scientific merit would be delegated to expert peers in return for scientific progress, which would ultimately benefit the nation in terms of scientific needs--military security, economic productivity, and enhanced quality of life. Bush wanted the funding of basic research intertwined with training, and preferred to use universities for this purpose rather than industrial or national labs. Bush viewed college and university scientists as teachers and investigators. He believed university-based research would uniquely encourage and engage the next generation of scientists as no other institutional arrangement could. Bush did not trust industry's commitment to basic research, an instinct that proved prophetic. The academic reserve of scientists (PhD's in training and postdoctoral students) that existed before World War II, and upon which the United States could draw for its needs, which were primarily associated with defense efforts, was probably one of the defining factors in Bush's suggested strategy. Currently, that reserve of talent has gotten so large that it is the obvious throttle in the pipeline slowing the continued development of the university research enterprise. Since 1977, the rate at which we have trained new scientists exceeds an average of 4% annually. Since 1987, the "science work force"--PhD's--has grown at three times the rate of the general labor supply. Temporary positions for postdoctoral scientists have grown even faster (over 5% per year since 1989). To compound the problem, the 1990 Immigration Reform Act resulted in a tripling of job-based visas, with scientists representing nearly one-third of the total. In 1979, two of every three postdoctoral scientists were U.S.-born; in 1992, the ratio was about one to one. Over that period, the cohort of postdoctoral scientists grew from 18,000 to 33,000. Adding to the coincidence of events that have compounded one another is the admission of 20,000 Chinese scientists in a ten-year period, the sudden and unexpected availability of Russian scientists, the elimination of many industrial laboratories as a result of downsizing, changes in the mandatory retirement age for faculty, and the disappearance of the Cold War, which all but eliminated the need for scientists for national security purposes. Is it any wonder that postdoctoral scientists have been called the migrant workers of today's high-tech society? What once was a reservoir of enthusiastic talent is becoming a dumping ground for credentialed and capable scientists exiled from the main stream of their disciplines. From a broader point of view, the problems facing U.S. science are those of our society: an imposing deficit that is shrinking discretionary funding; the end of the Cold War, which has refocused spending for national security; and a robust science work force that can no longer expand. The business world's response to these societal problems is, basically, downsizing, which often means the elimination of large segments of the work force, usually at the middle-management level. The initial academic response to these same problems is either to insist on more resources being made available, usually through federal agencies, in an attempt to maintain the status quo, or to engage in some form of "academic birth control." The former strategy is unrealistic because it just perpetuates the problem; there will never be enough research professorships in the academic world for every aspiring PhD produced in a discipline. The latter strategy will invariably decrease the flow of truly n

  19. Trends in Instructional Programs: Missouri Public Four-Year Colleges and Universities. Fiscal Year 1983-Fiscal Year 1987.

    ERIC Educational Resources Information Center

    Sweet, Arleene, Ed.

    An overview of changes related to instructional programs that have occurred at Missouri's public four-year institutions between fiscal year (FY) 1983 and FY 1987 is provided. This updates a similar report published in 1983 for the years 1972-1982. It is part of an effort to employ an analysis of enrollment patterns, program mix, and institutional…

  20. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures

    PubMed Central

    Bergey, Gregory K.; Mizrahi, Eli M.; Goldman, Alica; King-Stephens, David; Nair, Dileep; Srinivasan, Shraddha; Jobst, Barbara; Gross, Robert E.; Shields, Donald C.; Barkley, Gregory; Salanova, Vicenta; Olejniczak, Piotr; Cole, Andrew; Cash, Sydney S.; Noe, Katherine; Wharen, Robert; Worrell, Gregory; Murro, Anthony M.; Edwards, Jonathan; Duchowny, Michael; Spencer, David; Smith, Michael; Geller, Eric; Gwinn, Ryder; Skidmore, Christopher; Eisenschenk, Stephan; Berg, Michel; Heck, Christianne; Van Ness, Paul; Fountain, Nathan; Rutecki, Paul; Massey, Andrew; O'Donovan, Cormac; Labar, Douglas; Duckrow, Robert B.; Hirsch, Lawrence J.; Courtney, Tracy; Sun, Felice T.; Seale, Cairn G.

    2015-01-01

    Objective: The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures. Methods: All participants were treated with a cranially implanted responsive neurostimulator that delivers stimulation to 1 or 2 seizure foci via chronically implanted electrodes when specific electrocorticographic patterns are detected (RNS System). Participants had completed a 2-year primarily open-label safety study (n = 65) or a 2-year randomized blinded controlled safety and efficacy study (n = 191); 230 participants transitioned into an ongoing 7-year study to assess safety and efficacy. Results: The average participant was 34 (±11.4) years old with epilepsy for 19.6 (±11.4) years. The median preimplant frequency of disabling partial or generalized tonic-clonic seizures was 10.2 seizures a month. The median percent seizure reduction in the randomized blinded controlled trial was 44% at 1 year and 53% at 2 years (p < 0.0001, generalized estimating equation) and ranged from 48% to 66% over postimplant years 3 through 6 in the long-term study. Improvements in quality of life were maintained (p < 0.05). The most common serious device-related adverse events over the mean 5.4 years of follow-up were implant site infection (9.0%) involving soft tissue and neurostimulator explantation (4.7%). Conclusions: The RNS System is the first direct brain responsive neurostimulator. Acute and sustained efficacy and safety were demonstrated in adults with medically refractory partial onset seizures arising from 1 or 2 foci over a mean follow-up of 5.4 years. This experience supports the RNS System as a treatment option for refractory partial seizures. Classification of evidence: This study provides Class IV evidence that for adults with medically refractory partial onset seizures, responsive direct cortical stimulation reduces seizures and improves quality of life over a mean follow-up of 5.4 years. PMID:25616485

  1. A Survey of Interventional Radiology Awareness Among Final-Year Medical Students in a European Country

    SciTech Connect

    Leong, Sum; Keeling, Aoife N.; Lee, Michael J., E-mail: mlee@rcsi.i [Beaumont Hospital, Department of Academic Radiology (Ireland)

    2009-07-15

    Interventional radiology (IR) is a rapidly expanding specialty that is facing the challenges of turf wars and personnel shortages. Appropriate exposure of medical students to this field can be vital to recruitment of potential future trainees or referring physicians. The aim of this study was to determine the knowledge and views of final-year medical students in a single EU country regarding various aspects of IR. An electronic survey was sent via e-mail to all final-year medical students in a European country. The students were given a month to respond to the questionnaire. A total of 234 students of 675 (34.5%) replied to the survey. Of the respondents, 35% had previously completed an attachment to the radiology department. The majority of students (63%) thought their knowledge in radiology in general was poor. The percentage of students who correctly identified procedures performed by interventional radiologists was 69% for Hickman line insertion, 79% for fibroid embolization, and 67.5% for lower limb angioplasty. Sixty percent, 30%, and 47% thought that interventional radiologists perform cardiac angioplasties, perform arterial bypasses, and create AV fistulas, respectively. Forty-nine percent felt that interventional radiologists are surgically trained. Eighty-three percent of students were first made aware of angioplasty by a cardiologist. Thirty-one percent thought that interventional radiologists do ward rounds, 24% thought that interventional radiologists have admitting rights, and 26% felt that interventional radiologists run an outpatient practice. A significant number of students (76%) thought that the job prospects in IR are good or excellent but only 40.5% were willing to consider a career in IR. In conclusion, this study indicates that IR remains a nascent but attractive specialty to the majority of medical students. Further development of the existing informal undergraduate curriculum to address shortcomings will ensure that IR continues to attract the brightest talents to the field.

  2. Quality of surface-water supplies in the Triangle area of North Carolina, water year 2009

    USGS Publications Warehouse

    Pfeifle, C. A.; Giorgino, M. J.; Rasmussen, R. B.

    2014-01-01

    Surface-water supplies are important sources of drinking water for residents in the Triangle area of North Carolina, which is located within the upper Cape Fear and Neuse River Basins. Since 1988, the U.S. Geological Survey and a consortium of governments have tracked water-quality conditions and trends in several of the area’s water-supply lakes and streams. This report summarizes data collected through this cooperative effort, known as the Triangle Area Water Supply Monitoring Project, during October 2008 through September 2009. Major findings for this period include: - Annual precipitation was approximately 20 percent below the long-term mean (average) annual precipitation. - Streamflow was below the long-term mean at the 10 project streamgages during most of the year. - More than 7,000 individual measurements of water quality were made at a total of 26 sites—15 in the Neuse River Basin and 11 in the Cape Fear River Basin. Forty-seven water-quality properties and constituents were measured. - All observations met North Carolina water-quality standards for water temperature, pH, hardness, chloride, fluoride, sulfate, nitrate, arsenic, cadmium, chromium, lead, nickel, and selenium. - North Carolina water-quality standards were exceeded one or more times for dissolved oxygen, dissolved oxygen percent saturation, chlorophyll a, mercury, copper, iron, manganese, silver, and zinc. Exceedances occurred at 23 sites—13 in the Neuse River Basin and 10 in the Cape Fear River Basin. - Stream samples collected during storm events contained elevated concentrations of 18 water-quality constituents compared to samples collected during non-storm events. - Concentrations of nitrogen and phosphorus were within ranges observed during previous years. - Five reservoirs had chlorophyll a concentrations in excess of 40 micrograms per liter at least once during 2009: Little River Reservoir, Falls Lake, Cane Creek Reservoir, University Lake, and Jordan Lake.

  3. Stability of employment after brain injury: a 7-year follow-up study.

    PubMed

    Pössl, J; Jürgensmeyer, S; Karlbauer, F; Wenz, C; Goldenberg, G

    2001-01-01

    Forty-three patients with severe traumatic brain injury (n = 24), cerebrovascular diseases (n = 15), or other acquired brain damage (n = 4) were followed-up 7-8 years after neuropsychological rehabilitation including a vocational re-entry programme. Current vocational status and work history since rehabilitation were investigated by means of a structured interview. Before interview, the patients were classified on the basis of medical records into four groups: (A) patients with minor residual neuropsychological impairments, (B) patients with minor impairments but psychopathological symptoms, (C) patients with persistent neuropsychological impairments showing no psychopathological symptoms, and (D) patients with persistent impairments and psychopathological symptoms. For patients in group A, a good, and for those in group D, a poor long-term employment outcome was predicted, while no predictions were made for the intermediate groups. Of the 43 interviewed subjects, 16 (37%) reported a stable return to work at pre-morbid level and seven (16%) at a lower level. In eight patients (19%), persisting difficulties in maintaining work were documented. Twelve subjects (28%) had retired within a period of 2 years after work trial. The relationship between patient classification and long-term employment outcome was only weak. Four out of 11 patients with a good prognosis (group A) experienced vocational adjustment problems or had retired. Three out of 10 patients with a poor prognosis (group D) were able to continue successfully with their previous jobs. These cases are described in detail. The employment outcome of the intermediate groups was very heterogeneous. The results suggest that particular attention should be paid to the long-term consequences of a reduced capacity for work, even if minor in degree. The success of patients despite a poor prognosis illustrate unsolved problems in relation to the ecological validity of neuropsychological measures of executive dysfunctions. PMID:11201311

  4. Ocular manifestations of graft-versus-host disease: 10 years’ experience

    PubMed Central

    Lin, Xihui; Cavanagh, Harrison Dwight

    2015-01-01

    Purpose To evaluate the ocular presentation, treatment, and clinical course of graft-versus-host disease (GVHD). Design Retrospective case series. Participants Two hundred and forty-nine patients with systemic GVHD were included in the study. Methods Ocular and systemic data were collected from 2003 to 2013. Main outcome measures Mortality, visual acuity, and response of ocular symptoms. Results Sixty-four patients had ocular manifestations (25.7%). At presentation, the mean age was 44.5 years and mean latency was 16.4 months. The most common presentations were keratoconjunctivitis sicca, cataract, blepharitis, ocular hypertension, and filamentary keratitis. Visual acuity at presentation was 20/49; at the worst point in the disease was 20/115; and at most recent visit was 20/63. When topical anti-inflammatory drops were used in addition to tears, 54.3% of patients’ ocular symptoms stabilized. When autologous serum was used in addition, 80% stabilized. The overall 10-year mortality of GVHD was 29.7%. For those with ocular involvement, it was 21.9%. Conclusion Systemic GVHD has a high mortality rate, but ocular involvement does not suggest a worse prognosis. The main ocular presentations were keratoconjunctivitis sicca, cataracts, and ocular hypertension. Dry eyes in this population were very severe with overall worsening in visual acuity. However, with a step-wise approach involving topical anti-inflammatory medications and autologous serum tears, ocular symptoms do improve. It is important to monitor these patients closely, as they are prone to serious ocular complications such as corneal perforation and endophthalmitis.

  5. Academic Plan Year One: Progress and Achievements

    E-print Network

    Academic Plan ­ Year One: Progress and Achievements Faculty of Applied Science & Engineering University of Toronto December 2012 #12; Faculty of Applied Science & Engineering Academic Plan -- Year One: Progress and Achievements 2 of 21 Table of Contents Executive Summary

  6. Budget estimates, fiscal years 1994--1995

    SciTech Connect

    Not Available

    1993-04-01

    This report contains the fiscal year budget justification to Congress. The budget provides estimates for salaries and expenses and for the Office of the Inspector General for fiscal years 1994 and 1995.

  7. Fun Ideas for Being Active All Year

    MedlinePLUS

    ... nih.gov/Go4Life Fun Ideas for Being Active All Year January: Start the new year by trying ... in your garden. Bending, lifting, and stretching are all great exercises. May: Build your endurance and strength ...

  8. Au Boulot! First-Year French

    E-print Network

    Dinneen, David A.; Christiansen, Hope; Kernen, Madeleine; Pensec, Herve

    1995-01-01

    Au boulot! is a two-year college French program consisting of: two textbooks, one for each year; four workbooks, one for each semester; four cassette sets to accompany the four workbooks; and a reference grammar, to be ...

  9. 50 CFR 622.7 - Fishing years.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...September 30. (b) King and Spanish mackerel. The fishing year for the king and Spanish mackerel bag limits specified in § 622.382 is...years apply only for the king and Spanish mackerel quotas specified in § 622.384:...

  10. 50 CFR 622.7 - Fishing years.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...September 30. (b) King and Spanish mackerel. The fishing year for the king and Spanish mackerel bag limits specified in § 622.382 is...years apply only for the king and Spanish mackerel quotas specified in § 622.384:...

  11. 50 CFR 622.30 - Fishing years.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...September 30. (b) King and Spanish mackerel. The fishing year for the king and Spanish mackerel bag limits specified in § 622.39...years apply only for the king and Spanish mackerel quotas specified in §...

  12. On the Rule for Leap Year.

    PubMed

    Wylie, C C

    1956-05-11

    Harold F. Gray, of Corning, Calif., has called my attention to an error in the note "On the rule for leap year" [Science 123, 544 (30 Mar. 1956)]. In the sixth paragraph of the article (page 545), the end of the second sentence should read ". . . the century years 1800, 1900, and 2100 are not divisible by 400 and, hence, are not leap years; but 2000 is divisible by 400 and, hence, is a leap year." PMID:17821655

  13. Perceptions of Teachers in Their First Year of School Restructuring: Failure to Make Adequate Yearly Progress

    ERIC Educational Resources Information Center

    Moser, Sharon

    2010-01-01

    The 2007-2008 school year marked the first year Florida's Title I schools that did not made Adequate Yearly Progress (AYP) for five consecutive years entered into restructuring as mandated by the "No Child Left Behind Act" of 2001. My study examines the perceptions of teacher entering into their first year of school restructuring due to failure to…

  14. 2014 ACADEMIC CALENDAR (YEAR 2: CLINICAL) 1 New Year's Day observed. Administrative offices closed

    E-print Network

    Dennett, Daniel

    2014 ACADEMIC CALENDAR (YEAR 2: CLINICAL) JANUARY 1 New Year's Day observed. Administrative offices on this calendar, and classes are not held for first year PA students. Observation of all holidays by second year responsibilities. Holidays observed on the TUSM school calendar do not define holidays for second year students

  15. 29 CFR 548.306 - Average earnings for year or quarter year preceding the current quarter.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...earnings for year or quarter year preceding the current quarter. 548.306 Section 548...for year or quarter year preceding the current quarter. (a) Section 548.3(f...employee's regular rates of pay during the current quarter year, and (ii) such...

  16. 29 CFR 548.306 - Average earnings for year or quarter year preceding the current quarter.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...earnings for year or quarter year preceding the current quarter. 548.306 Section 548...for year or quarter year preceding the current quarter. (a) Section 548.3(f...employee's regular rates of pay during the current quarter year, and (ii) such...

  17. 29 CFR 548.306 - Average earnings for year or quarter year preceding the current quarter.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...earnings for year or quarter year preceding the current quarter. 548.306 Section 548...for year or quarter year preceding the current quarter. (a) Section 548.3(f...employee's regular rates of pay during the current quarter year, and (ii) such...

  18. 29 CFR 548.306 - Average earnings for year or quarter year preceding the current quarter.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...earnings for year or quarter year preceding the current quarter. 548.306 Section 548...for year or quarter year preceding the current quarter. (a) Section 548.3(f...employee's regular rates of pay during the current quarter year, and (ii) such...

  19. Year in Industry Scheme The Year in Industry Scheme allows you to spend

    E-print Network

    Haase, Markus

    Year in Industry Scheme The Year in Industry Scheme allows you to spend your third year in full-time paid employment, returning to the University for a final fourth year. You are awarded a BSc (Industry and generally expect to earn an annual salary of £15,000-25,000, but it can be higher. The Industrial year

  20. Year in Industry Scheme The Year in Industry Scheme allows you to spend

    E-print Network

    Haase, Markus

    Year in Industry Scheme The Year in Industry Scheme allows you to spend your third year in full not (and often will not) involve university-level mathematics. The Industrial year is assessed on a pass indicates that, when recruiting, most employers look favourably upon a year spent in industry. Highlights

  1. HMS Second-Year Financial Aid Update

    E-print Network

    Goodrich, Lisa V.

    Application Deadline Third Year Financial Aid Process Five Year Plans Debt Profiles Repayment Options HMSHMS Second-Year Financial Aid Update February 2014 #12;Today's Agenda 2014-15 Financial Aid Loan Forgiveness & Repayment Programs AAMC FIRST Tools Financial Literacy Session ­ Mr. Thomas Murphy

  2. Early Years: Where Does Science Fit In?

    ERIC Educational Resources Information Center

    Rogers, Victoria

    2012-01-01

    Science provides foundations for people to understand what is happening around them, supplies information for developments to be made and explains why things happen. As a science and early years specialist, the author often wondered how early years and science can be combined. Where is the place of science within the Early Years Foundation Stage…

  3. Kepler: 400 years later Jonas Karlsson

    E-print Network

    Weinberger, Hans

    Kepler: 400 years later #12;Outline Kepler's laws Proof that closed orbits are ellipses The hydrogen atom Geodesic ow and the Kepler manifold Jonas Karlsson Kepler: 400 years later #12;Kepler's laws Johannes Kepler (1571 - 1630) Jonas Karlsson Kepler: 400 years later #12;Kepler's laws First law (1609

  4. BA: Art History Fall--First Year

    E-print Network

    Gering, Jon C.

    BA: Art History Fall--First Year · ART 127 New Major Seminar · ART 222 Caves to Cathedrals · Liberal Studies Program (LSP) coursework Fall--Second Year · ART 101 Art Studio Foundations I · ART 324 Renaissance Art · Liberal Studies Program (LSP) coursework Fall--Third Year · ART 328 Art of Greece & Rome

  5. Year-Round versus Traditional Schools

    ERIC Educational Resources Information Center

    Lyttle, LeighAnne

    2011-01-01

    This document serves as a literature review for the practicality and cost effectiveness of traditional versus year-round school systems. The differences in year-round and traditional schools are many, as the debate lingers on which type is best for students' learning. Generally conclusive, the literature indicates that year-round schools' benefits…

  6. FISHERIES LOAN FUND fiscal year 1957

    E-print Network

    FISHERIES LOAN FUND fiscal year 1957 FISH AND WILDLIFE CIRCULAR 103 UNITED STATE DEPARTMENT REPORT OF FISHERIES LOAN FUND FISCAL YEAR 1957 For many years commercial fishermen of the United States loans on fishing vessels except in exceptional cases. Maintenance of fishing vessels and gear suffered

  7. Year 1 Academic Student Handbook 2013 2014

    E-print Network

    Myers, Lawrence C.

    calendar 12 Year 1 master schedules vs. course schedules 13 Class starting and ending times/breaks 13 Year If you have a question regarding: Please contact: Year 1 overall program policies Dr. Virginia Lyons policy) Virginia Lyons Request to delay a final exam Virginia Lyons Conditions in the lecture hall

  8. Negotiating the Curriculum: Surviving the First Year

    ERIC Educational Resources Information Center

    Poland, Molly

    2013-01-01

    Molly Poland is a first year English and Home Economics teacher who began her career in a small Far North Queensland town. In this article, she writes about her first year teaching and the last year of her degree and the challenges she faced as both teacher and student. Reading Boomer's "Negotiating the Curriculum" forced her to…

  9. Acute mastoiditis: a 10 year retrospective study

    Microsoft Academic Search

    V. Tarantino; R D'Agostino; G. Taborelli; A. Melagrana; A. Porcu; M. Stura

    2002-01-01

    This retrospective study reviews our experience in the management of acute otomastoiditis over 10 years. During the study period we identified 40 cases in children aged 3 months–15 years with a peak incidence in the second year of life. Sixty per cent of them had a history of acute otitis media (AOM). All the children were already receiving oral antibiotic

  10. 11 Years Engineering Geology Fieldwork in

    E-print Network

    Hack, Robert

    ;14 dec 2001 11 years engineering geology in Falset - science from fieldwork - hack 2 What did we Produce ? Why did we ? #12;14 dec 2001 11 years engineering geology in Falset - science from fieldwork - hack 3 happy #12;14 dec 2001 11 years engineering geology in Falset - science from fieldwork - hack 4 Why keep

  11. Foundation Year Programmes: AGuideforParents

    E-print Network

    Anderson, Jim

    Foundation Year Programmes: AGuideforParents #12;Welcometo Southampton Studying in the UK is a long exciting adventures of their life. Our foundation year courses are designed to help your son or daughter, foundation year students who meet the required criteria are guaranteed a place on an undergraduate course

  12. A New Take on New Year Celebrations

    ERIC Educational Resources Information Center

    Montgomery, Sarah E.; Christie, Erica M.

    2011-01-01

    People all over the world relish the opportunity to count down the final moments of the year and welcome an exciting New Year full of opportunities and fresh beginnings. Different cultures have historical traditions of welcoming in the New Year, from eating black-eyed peas in the American South to creating geometric "Rangoli" (a form of…

  13. Vegetation management 1994 fiscal year end report

    SciTech Connect

    Rodriguez, J.M.

    1995-02-01

    This year-end report evaluates vegetation management operations on the Hanford reservation conducted during fiscal year (FY) 1994 and proposed control methods to be used in FY 1995 and following years. The 1995 control methods proposed are based on an evaluation of past and current ALARA principles, employee safety, environmental impacts, applicable regulations, site esthetics, and other site-specific factors.

  14. Energy, Incandescent Lighting, and 100 Years

    Microsoft Academic Search

    Kao Chen; William A. Murray

    1980-01-01

    1979 was the centennial year of light. 100 years ago Edison invented the first practical incandescent lamp. Since then the lamp industry has taken giant steps in developing and perfecting more efficient and diverse light sources. However, the incandescent light source 100 years after its invention continues to keep pace with the industry, providing the backbone to the lighting industry.

  15. Fiscal Year 2005 Performance and Accountability Report

    ERIC Educational Resources Information Center

    US Department of Education, 2005

    2005-01-01

    As the Department looks back on FY 2005, it reflects on successes like the national sample of 9-year-olds whose reading scores are higher this year than in any previous assessment year and challenges like those with collecting reliable, valid, and timely data. This report presents complete, reliable information that demonstrates the Department's…

  16. 40 years later, France debates, dissects, and disagrees about the legacy of student protest

    NSDL National Science Digital Library

    Grinnell, Max

    2008-05-02

    France Still Divided Over Lessons of 1968 Unrest [Free registration may be required]http://www.nytimes.com/2008/04/29/world/europe/30france.html?_r=1&oref=sloginVisiting the ghosts of Paris 1968http://news.bbc.co.uk/2/hi/programmes/from_our_own_correspondent/7354335.stmTime: Battle of the Sorbonnehttp://www.time.com/time/magazine/article/0,9171,838353,00.htmlBBC Radio 4: 1968, the Year of Revolutions [Real Player]http://www.bbc.co.uk/radio4/1968/yearofrevolutions.shtmlEchoes of 1968 [Real Player]http://www.npr.org/templates/story/story.php?storyId=89372462Revolution was certainly nothing new to France in 1968, but a series of student protests that began at Nanterre University in March that year continues to be a polarizing subject of conversation throughout the country. Eventually the university was closed in May, and students began a widespread attack on the outdated rules imposed on them by the university system across France. Demonstrations and riots soon engulfed the Latin Quarter and the Sorbonne and forty years later, the country remains deeply divided about the legacy of these events. Even the language used by different factions within French society reflects the stark differences, as the right refers to the protests as "the events", while the left refers to these protests as "the movement". One person who has not minced any words about his feelings on the matter is French president Nicolas Sarkozy, who has stated that May 1968 represents anarchy and moral relativism. A student activist from that period, Andre Glucksmann, recently commented, "Sarkozy is the first post-'68 president. To liquidate '68 is to liquidate himself." The first link leads to an excellent article from this Tuesday's The Age (Melbourne), which discusses the legacy of the student protests and demonstrations in France 40 years ago. The second link will whisk users away to an article from the New York Times about the legacy of the protests and general perceptions about these events in contemporary France. The third link will take visitors to a personal reflection on the protests offered by BBC correspondent John Pickford. Moving on, the fourth link leads to a piece on the protests that originally appeared in the May 17, 1968 edition of Time magazine. The fifth link whisks users away to a four-part series from the BBC on the "year of revolutions" conducted by Sir John Tusa. The final link will lead visitors to a nice series from National Public Radio on the various social and political upheavals going on in the United States during 1968.

  17. Lexical-semantic body knowledge in 5- to 11-year-old children: How spatial body representation influences body semantics.

    PubMed

    Auclair, Laurent; Jambaqué, Isabelle

    2015-07-01

    This study addresses the relation between lexico-semantic body knowledge (i.e., body semantics) and spatial body representation (i.e., structural body representation) by analyzing naming performances as a function of body structural topography. One hundred and forty-one children ranging from 5 years 2 months to 10 years 5 months old were asked to provide a lexical label for isolated body part pictures. We compared the children's naming performances according to the location of the body parts (body parts vs. head features and also upper vs. lower limbs) or to their involvement in motor skills (distal segments, joints, and broader body parts). The results showed that the children's naming performance was better for facial body parts than for other body parts. Furthermore, it was found that the naming of body parts was better for body parts related to action. These findings suggest that the development of a spatial body representation shapes the elaboration of semantic body representation processing. Moreover, this influence was not limited to younger children. In our discussion of these results, we focus on the important role of action in the development of body representations and semantic organization. PMID:24814800

  18. Urinary tract re-functionalization after long-term diversion. A 20-year experience with 177 patients.

    PubMed Central

    Hendren, W H

    1990-01-01

    From 1969 to 1990, previously diverted urinary tracts were 'undiverted' in 177 patients whose ages ranged from 1 to 31 years. Fifty-six of the patients (32%) had been diverted for 10 years or longer. There were 67 female and 110 male patients. Forty-four patients had only one kidney and in two of those patients it was a previous renal transplant. One patient was anephric at the time of reconstruction, having had two unsuccessful transplants. Most of the diversions had been considered permanent. Types of diversions that were reversed include ileal loop, colon conduit, loop ureterostomy or pyelostomy, end ureterostomy, cystostomy or vesicostomy, long-term nephrostomy, and ureterosigmoidostomy. Images Fig. 6. Figs. 8A and B. Figs 10A and B. Figs. 12A and B. Figs. 14A and B. Figs. 16A-D. Figs 20A and B. Figs.22A and B. Figs. 24A and B. Figs. 25A and B. Figs. 28A-D. PMID:2222014

  19. PHMC Year 2000 handbook: Volume 1

    SciTech Connect

    Layfield, K.A.

    1998-09-02

    The PHMC [Project Hanford Management Contract] Year 2000 Project involves the effective cooperation and participation of the Year 2000 Project Office, FDH Project Direction, FDH Chief Information Officer, major subcontractors and DynCorp. The primary responsibilities of the Year 2000 Project Office is to develop and facilitate a Year 2000 approach, provide an awareness program, report status, and perform compliance assurance reviews. The primary responsibility of the FDH Project Directors is to direct the major subcontractors, and DynCorp toward the successful completion of Year 2000 activities.

  20. The Effect of Donor Age on Penetrating Keratoplasty for Endothelial Disease: Graft Survival after 10 Years in the Cornea Donor Study

    PubMed Central

    Mannis, Mark J.; Holland, Edward J; Gal, Robin L.; Dontchev, Mariya; Kollman, Craig; Raghinaru, Dan; Dunn, Steven P.; Schultze, Robert L.; Verdier, David D.; Lass, Jonathan H.; Raber, Irving M.; Sugar, Joel; Gorovoy, Mark S.; Sugar, Alan; Stulting, R. Doyle; Montoya, Monty M.; Penta, Jeffrey G.; Benetz, Beth Ann; Beck, Roy W.

    2013-01-01

    Objective To determine whether the 10-year success rate of penetrating keratoplasty for corneal endothelial disorders is associated with donor age. Design Multi-center, prospective, double-masked clinical trial Participants 1090 participants undergoing penetrating keratoplasty at 80 sites for Fuchs’ dystrophy (62%), pseudophakic/aphakic corneal edema (34%) or another corneal endothelial disorder (4%) and followed for up to 12 years. Methods Forty-three eye banks provided corneas from donors 12 to 75 years old, using a randomized approach to assign donor corneas to study participants, without respect to recipient factors. Surgery and postoperative care were performed according to the surgeons’ usual routines. Main Outcome Measure Graft failure defined as a regraft or in the absence of a regraft, a cloudy cornea that was sufficiently opaque to compromise vision for 3 consecutive months. Results In the primary analysis, the 10-year success rate was 77% for 707 corneas from donors 12 to 65 years old compared with 71% for 383 donors 66 to 75 years old (difference = +6%, 95% confidence interval = ?1% to +12%, P=0.11). When analyzed as a continuous variable, higher donor age was associated with lower graft success after the first 5 years (P<0.001). Exploring this association further, we observed that the 10-year success rate was relatively constant for donors 34 to 71 years old (75%). The success rate was higher for 80 donors 12 to 33 (96%) and lower for 130 donors 72 to 75 years old (62%). The relative drop in the success rate with donor ages 72 to 75 years was not observed until after year 6. Conclusions Although the primary analysis did not show a significant difference in 10-year success rates comparing donor ages 12 to 65 and 66 to 75 years, there was evidence of a donor age effect at the extremes of the age range. Since we observed a fairly constant 10-year success rate for donors age 34 to 71 years, which account for approximately 75% of corneas in the United States available for transplant, the Cornea Donor Study results indicate that donor age is not an important factor in most penetrating keratoplasties for endothelial disease. PMID:24246825