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Sample records for newly organized irphep

  1. INTEGRAL BENCHMARK DATA FOR NUCLEAR DATA TESTING THROUGH THE ICSBEP AND THE NEWLY ORGANIZED IRPHEP

    SciTech Connect

    J. Blair Briggs; Lori Scott; Yolanda Rugama; Enrico Satori

    2007-04-01

    The status of the International Criticality Safety Benchmark Evaluation Project (ICSBEP) was last reported in a nuclear data conference at the International Conference on Nuclear Data for Science and Technology, ND-2004, in Santa Fe, New Mexico. Since that time the number and type of integral benchmarks have increased significantly. Included in the ICSBEP Handbook are criticality-alarm / shielding and fundamental physic benchmarks in addition to the traditional critical / subcritical benchmark data. Since ND 2004, a reactor physics counterpart to the ICSBEP, the International Reactor Physics Experiment Evaluation Project (IRPhEP) was initiated. The IRPhEP is patterned after the ICSBEP, but focuses on other integral measurements, such as buckling, spectral characteristics, reactivity effects, reactivity coefficients, kinetics measurements, reaction-rate and power distributions, nuclide compositions, and other miscellaneous-type measurements in addition to the critical configuration. The status of these two projects is discussed and selected benchmarks highlighted in this paper.

  2. Newly Available Reactor Physics Benchmark data in the March 2011 Edition of the IRPhEP Handbook

    SciTech Connect

    John D. Bess; J. Blair Briggs; Jim Gulliford

    2011-06-01

    The International Reactor Physics Experiment Evaluation Project (IRPhEP) was established to preserve integral reactor physics experimental data, including separate or special effects data for nuclear energy and technology applications. Numerous experiments that have been performed worldwide, represent a large investment of infrastructure, expertise, and cost, and are valuable resources of data for present and future research. These valuable assets provide the basis for recording, development, and validation of methods. If the data are compromised, it is unlikely that any of these measurements would be repeated in the future. The purpose of the IRPhEP is to provide an extensively peer-reviewed set of reactor physics-related integral data that can be used by reactor designers and safety analysts to validate the analytical tools used to design next-generation reactors and establish the safety basis for operation of these reactors. Contributors from around the world collaborate in the evaluation and review of selected benchmark experiments for inclusion in the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook). Several new evaluations have been prepared for inclusion in the March 2011 edition of the IRPhEP Handbook.

  3. Benchmark Data Through The International Reactor Physics Experiment Evaluation Project (IRPHEP)

    SciTech Connect

    J. Blair Briggs; Dr. Enrico Sartori

    2005-09-01

    The International Reactor Physics Experiments Evaluation Project (IRPhEP) was initiated by the Organization for Economic Cooperation and Development (OECD) Nuclear Energy Agency’s (NEA) Nuclear Science Committee (NSC) in June of 2002. The IRPhEP focus is on the derivation of internationally peer reviewed benchmark models for several types of integral measurements, in addition to the critical configuration. While the benchmarks produced by the IRPhEP are of primary interest to the Reactor Physics Community, many of the benchmarks can be of significant value to the Criticality Safety and Nuclear Data Communities. Benchmarks that support the Next Generation Nuclear Plant (NGNP), for example, also support fuel manufacture, handling, transportation, and storage activities and could challenge current analytical methods. The IRPhEP is patterned after the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and is closely coordinated with the ICSBEP. This paper highlights the benchmarks that are currently being prepared by the IRPhEP that are also of interest to the Criticality Safety Community. The different types of measurements and associated benchmarks that can be expected in the first publication and beyond are described. The protocol for inclusion of IRPhEP benchmarks as ICSBEP benchmarks and for inclusion of ICSBEP benchmarks as IRPhEP benchmarks is detailed. The format for IRPhEP benchmark evaluations is described as an extension of the ICSBEP format. Benchmarks produced by the IRPhEP add new dimension to criticality safety benchmarking efforts and expand the collection of available integral benchmarks for nuclear data testing. The first publication of the "International Handbook of Evaluated Reactor Physics Benchmark Experiments" is scheduled for January of 2006.

  4. The International Reactor Physics Experiment Evaluation Project (IRPhEP)

    SciTech Connect

    Blair Briggs, J.; Sartori, E.; Scott, L.

    2006-07-01

    Since the beginning of the Nuclear Power industry, numerous experiments concerned with nuclear energy and technology have been performed at different research laboratories, worldwide. These experiments required a large investment in terms of infrastructure, expertise, and cost; however, many were performed without a high degree of attention to archival of results for future use. The degree and quality of documentation varies greatly. There is an urgent need to preserve integral reactor physics experimental data, including measurement methods, techniques, and separate or special effects data for nuclear energy and technology applications and the knowledge and competence contained therein. If the data are compromised, it is unlikely that any of these experiments will be repeated again in the future. The International Reactor Physics Evaluation Project (IRPhEP) was initiated, as a pilot activity in 1999 by the by the Organization of Economic Cooperation and Development (OECD) Nuclear Energy Agency (NEA) Nuclear Science Committee (NSC). The project was endorsed as an official activity of the NSC in June of 2003. The purpose of the IRPhEP is to provide an extensively peer reviewed set of reactor physics related integral benchmark data that can be used by reactor designers and safety analysts to validate the analytical tools used to design next generation reactors and establish the safety basis for operation of these reactors. A short history of the IRPhEP is presented and its purposes are discussed in this paper. Accomplishments of the IRPhEP, including the first publication of the IRPhEP Handbook, are highlighted and the future of the project outlined. (authors)

  5. The International Reactor Physics Experiment Evaluation Project (IRPHEP)

    SciTech Connect

    J. Blair Briggs; Enrico Sartori; Lori Scott

    2006-09-01

    Since the beginning of the Nuclear Power industry, numerous experiments concerned with nuclear energy and technology have been performed at different research laboratories, worldwide. These experiments required a large investment in terms of infrastructure, expertise, and cost; however, many were performed without a high degree of attention to archival of results for future use. The degree and quality of documentation varies greatly. There is an urgent need to preserve integral reactor physics experimental data, including measurement methods, techniques, and separate or special effects data for nuclear energy and technology applications and the knowledge and competence contained therein. If the data are compromised, it is unlikely that any of these experiments will be repeated again in the future. The International Reactor Physics Evaluation Project (IRPhEP) was initiated, as a pilot activity in 1999 by the by the Organization of Economic Cooperation and Development (OECD) Nuclear Energy Agency (NEA) Nuclear Science Committee (NSC). The project was endorsed as an official activity of the NSC in June of 2003. The purpose of the IRPhEP is to provide an extensively peer reviewed set of reactor physics related integral benchmark data that can be used by reactor designers and safety analysts to validate the analytical tools used to design next generation reactors and establish the safety basis for operation of these reactors. A short history of the IRPhEP is presented and its purposes are discussed in this paper. Accomplishments of the IRPhEP, including the first publication of the IRPhEP Handbook, are highlighted and the future of the project outlined.

  6. Integral Benchmark Data for Nuclear Data Testing Through the ICSBEP & IRPhEP

    SciTech Connect

    J. Blair Briggs; John D. Bess; Jim Gulliford; Ian Hill

    2013-10-01

    The status of the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and International Reactor Physics Experiment Evaluation Project (IRPhEP) was last discussed directly with the nuclear data community at ND2007. Since ND2007, integral benchmark data that are available for nuclear data testing have increased significantly. The status of the ICSBEP and the IRPhEP is discussed and selected benchmark configurations that have been added to the ICSBEP and IRPhEP Handbooks since ND2007 are highlighted.

  7. Overview of the 2014 Edition of the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook)

    SciTech Connect

    John D. Bess; J. Blair Briggs; Jim Gulliford; Ian Hill

    2014-10-01

    The International Reactor Physics Experiment Evaluation Project (IRPhEP) is a widely recognized world class program. The work of the IRPhEP is documented in the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook). Integral data from the IRPhEP Handbook is used by reactor safety and design, nuclear data, criticality safety, and analytical methods development specialists, worldwide, to perform necessary validations of their calculational techniques. The IRPhEP Handbook is among the most frequently quoted reference in the nuclear industry and is expected to be a valuable resource for future decades.

  8. 40 CFR 268.38 - Waste specific prohibitions-newly identified organic toxicity characteristic wastes and newly...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Waste specific prohibitions-newly identified organic toxicity characteristic wastes and newly listed coke by-product and chlorotoluene production wastes. 268.38 Section 268.38 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND...

  9. Growth and Expansion of the International Criticality Safety Benchmark Evaluation Project and the Newly Organized International Reactor Physics Experiment Evaluation Project

    SciTech Connect

    J. Blair Briggs; Lori Scott; Yolanda Rugama; Enrico Satori

    2007-05-01

    Since ICNC 2003, the International Criticality Safety Benchmark Evaluation Project (ICSBEP) has continued to expand its efforts and broaden its scope. Criticality-alarm / shielding type benchmarks and fundamental physics measurements that are relevant to criticality safety applications are not only included in the scope of the project, but benchmark data are also included in the latest version of the handbook. A considerable number of improvements have been made to the searchable database, DICE and the criticality-alarm / shielding benchmarks and fundamental physics measurements have been included in the database. There were 12 countries participating on the ICSBEP in 2003. That number has increased to 18 with recent contributions of data and/or resources from Brazil, Czech Republic, Poland, India, Canada, and China. South Africa, Germany, Argentina, and Australia have been invited to participate. Since ICNC 2003, the contents of the “International Handbook of Evaluated Criticality Safety Benchmark Experiments” have increased from 350 evaluations (28,000 pages) containing benchmark specifications for 3070 critical or subcritical configurations to 442 evaluations (over 38,000 pages) containing benchmark specifications for 3957 critical or subcritical configurations, 23 criticality-alarm-placement / shielding configurations with multiple dose points for each, and 20 configurations that have been categorized as fundamental physics measurements that are relevant to criticality safety applications in the 2006 Edition of the ICSBEP Handbook. Approximately 30 new evaluations and 250 additional configurations are expected to be added to the 2007 Edition of the Handbook. Since ICNC 2003, a reactor physics counterpart to the ICSBEP, The International Reactor Physics Experiment Evaluation Project (IRPhEP) was initiated. Beginning in 1999, the IRPhEP was conducted as a pilot activity by the by the Organization of Economic Cooperation and Development (OECD) Nuclear Energy

  10. New Reactor Physics Benchmark Data in the March 2012 Edition of the IRPhEP Handbook

    SciTech Connect

    John D. Bess; J. Blair Briggs; Jim Gulliford

    2012-11-01

    The International Reactor Physics Experiment Evaluation Project (IRPhEP) was established to preserve integral reactor physics experimental data, including separate or special effects data for nuclear energy and technology applications. Numerous experiments that have been performed worldwide, represent a large investment of infrastructure, expertise, and cost, and are valuable resources of data for present and future research. These valuable assets provide the basis for recording, development, and validation of methods. If the experimental data are lost, the high cost to repeat many of these measurements may be prohibitive. The purpose of the IRPhEP is to provide an extensively peer-reviewed set of reactor physics-related integral data that can be used by reactor designers and safety analysts to validate the analytical tools used to design next-generation reactors and establish the safety basis for operation of these reactors. Contributors from around the world collaborate in the evaluation and review of selected benchmark experiments for inclusion in the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook) [1]. Several new evaluations have been prepared for inclusion in the March 2012 edition of the IRPhEP Handbook.

  11. [Comprehensive evaluation of improving effects of different organic wastes on a newly reclaimed cultivated land].

    PubMed

    Xu, Qiu-tong; Kong, Zhang-liang; Zhang, Ming-kui

    2016-02-01

    There are many problems such as low soil organic matter, available nutrients and microbial activity, compaction, and poor tillage properties for a newly reclaimed cultivated land, and the establishment of a fast, effective measure for improving soil fertility quality is of importance to enhance the quality and production performance of the newly cultivated land. A field experiment was carried out to observe the effect of organic wastes on soil fertility of a newly reclaimed cultivated land, and compared the differences of different types of urban organic wastes. The field experiment included nine treatments, i.e., pig manure, chicken manure, rice straw, vegetable harvest residue, urban sludge, biogas residue, manure+rice straw compost, garbage compost and control without organic fertilizer at annual application rate of 30 t . hm-2, and ran for three consecutive years. The results showed that the application of each type of the eight organic wastes had obvious effects on improving soil fertility. Among them, pig manure, chicken manure, pig manure+rice straw compost, rice straw and biogas residue were the most effective to enhance the carbon pool management index of soil. The addition of pig manure+rice straw compost and biogas residue had the best effect on increasing the soil water stable aggregates and decreasing soil bulk density. Sewage sludge, pig manure+rice straw compost and garbage compost could enhance soil water holding capacity. Pig manure, chicken manure and pig manure+rice straw compost had most obvious effect on increasing soil available nutrients. All kinds of organic wastes increased the number of soil microorganisms and the activity of enzymes. There were some risk of soil heavy metals pollution.for the long-term application of sludge, garbage compost and manure. However, the impact of short-term application of the wastes on soil environmental quality was not obvious. Overall, effects of organic wastes on soil fertility decreased in the order of pig

  12. Measurements of Volatile Organic Compounds in a Newly Built Daycare Center

    PubMed Central

    Noguchi, Miyuki; Mizukoshi, Atsushi; Yanagisawa, Yukio; Yamasaki, Akihiro

    2016-01-01

    We measured temporal changes in concentrations of total volatile organic compounds (TVOCs) and individual volatile organic compounds in a newly built daycare center. The temporal changes of the TVOC concentrations were monitored with a photo ionization detector (PID), and indoor air was sampled and analyzed by Gas Chromatography/Mass Spectrometry (GC/MS) and high performance liquid chromatography (HPLC) to determine the concentrations of the constituent VOCs. The measurements were performed just after completion of the building and again 3 months after completion. The TVOC concentration exceeded 1000 µg·m−3 for all the sampling locations just after completion of building, and decreased almost one tenth after 3 months, to below the guideline values of the TVOC in Japan at 400 µg·m−3. The concentrations of the target VOCs of which the indoor concentrations are regulated in Japan were below the guideline values for all the cases. The air-exchange rates were determined based on the temporal changes of the TVOC concentrations, and it was found that the countermeasure to increase the air exchange rate successfully decrease the TVOC concentration level in the rooms. PMID:27455290

  13. Measurements of Volatile Organic Compounds in a Newly Built Daycare Center.

    PubMed

    Noguchi, Miyuki; Mizukoshi, Atsushi; Yanagisawa, Yukio; Yamasaki, Akihiro

    2016-01-01

    We measured temporal changes in concentrations of total volatile organic compounds (TVOCs) and individual volatile organic compounds in a newly built daycare center. The temporal changes of the TVOC concentrations were monitored with a photo ionization detector (PID), and indoor air was sampled and analyzed by Gas Chromatography/Mass Spectrometry (GC/MS) and high performance liquid chromatography (HPLC) to determine the concentrations of the constituent VOCs. The measurements were performed just after completion of the building and again 3 months after completion. The TVOC concentration exceeded 1000 µg·m(-3) for all the sampling locations just after completion of building, and decreased almost one tenth after 3 months, to below the guideline values of the TVOC in Japan at 400 µg·m(-3). The concentrations of the target VOCs of which the indoor concentrations are regulated in Japan were below the guideline values for all the cases. The air-exchange rates were determined based on the temporal changes of the TVOC concentrations, and it was found that the countermeasure to increase the air exchange rate successfully decrease the TVOC concentration level in the rooms. PMID:27455290

  14. Benchmark Development in Support of Generation-IV Reactor Validation (IRPhEP 2010 Handbook)

    SciTech Connect

    John D. Bess; J. Blair Briggs

    2010-06-01

    The March 2010 edition of the International Reactor Physics Experiment Evaluation Project (IRPhEP) Handbook includes additional benchmark data that can be implemented in the validation of data and methods for Generation IV (GEN-IV) reactor designs. Evaluations supporting sodium-cooled fast reactor (SFR) efforts include the initial isothermal tests of the Fast Flux Test Facility (FFTF) at the Hanford Site, the Zero Power Physics Reactor (ZPPR) 10B and 10C experiments at the Idaho National Laboratory (INL), and the burn-up reactivity coefficient of Japan’s JOYO reactor. An assessment of Russia’s BFS-61 assemblies at the Institute of Physics and Power Engineering (IPPE) provides additional information for lead-cooled fast reactor (LFR) systems. Benchmarks in support of the very high temperature reactor (VHTR) project include evaluations of the HTR-PROTEUS experiments performed at the Paul Scherrer Institut (PSI) in Switzerland and the start-up core physics tests of Japan’s High Temperature Engineering Test Reactor. The critical configuration of the Power Burst Facility (PBF) at the INL which used ternary ceramic fuel, U(18)O2-CaO-ZrO2, is of interest for fuel cycle research and development (FCR&D) and has some similarities to “inert-matrix” fuels that are of interest in GEN-IV advanced reactor design. Two additional evaluations were revised to include additional evaluated experimental data, in support of light water reactor (LWR) and heavy water reactor (HWR) research; these include reactor physics experiments at Brazil’s IPEN/MB-01 Research Reactor Facility and the French High Flux Reactor (RHF), respectively. The IRPhEP Handbook now includes data from 45 experimental series (representing 24 reactor facilities) and represents contributions from 15 countries. These experimental measurements represent large investments of infrastructure, experience, and cost that have been evaluated and preserved as benchmarks for the validation of methods and collection of

  15. 29 CFR 452.14 - Newly formed or merged labor organizations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... prescribed in these regulations must be held within a reasonable period after the organization begins to... formation or consolidation of the labor organization, a regular election subject to title IV may not be deferred longer than the statutory period provided for that type of organization. However, when a...

  16. Dissolved organic matter in newly formed sea ice and surface seawater

    NASA Astrophysics Data System (ADS)

    Longnecker, Krista

    2015-12-01

    Changes in sea ice in the Arctic will have ramifications on regional and global carbon cycling. Research to date has primarily focused on the regional impacts to biological activity and global impacts on atmospheric processes. The current project considers the molecular-level composition of organic carbon within sea ice compared to the organic matter in seawater. The project revealed that the composition of organic matter within sea ice was more variable than the composition of organic matter within the surface ocean. Furthermore, sea ice samples presented two distinct patterns in the composition of organic matter with a portion of the sea ice samples containing protein-like organic matter. Yet, the samples were collected in the early winter period when little biological activity is expected. Thus, one hypothesis is that physical processes acting during the formation of sea ice selectively transferred organic matter from seawater into sea ice. The present project expands our understanding of dissolved organic matter in sea ice and surface seawater and thereby increases our knowledge of carbon cycling in polar regions.

  17. The development of the olfactory organs in newly hatched monotremes and neonate marsupials.

    PubMed

    Schneider, Nanette Yvette

    2011-08-01

    Olfactory cues are thought to play a crucial role in the detection of the milk source at birth in mammals. It has been shown that a marsupial, the tammar wallaby, can detect olfactory cues from its mother's pouch at birth. This study investigates whether the main olfactory and accessory olfactory system are similarly well developed in other marsupials and monotremes at birth/hatching as in the tammar. Sections of the head of various marsupial and two monotreme species were investigated by light microscopy. Both olfactory systems were less well developed in the kowari and Eastern quoll. No olfactory or vomeronasal or terminal nerves could be observed; the main olfactory bulb (MOB) had only two layers while no accessory olfactory bulb or ganglion terminale were visible. All other investigated marsupials and monotremes showed further developed olfactory systems with olfactory, vomeronasal and terminal nerves, a three-layered MOB, and in the marsupials a prominent ganglion terminale. The main olfactory system was further developed than the accessory olfactory system in all species investigated. The olfactory systems were the least developed in species in which the mother's birth position removed most of the difficulty in reaching the teat, placing the neonate directly in the pouch. In monotremes they were the furthest developed as Bowman glands were found underlying the main olfactory epithelium. This may reflect the need to locate the milk field each time they drink as they cannot permanently attach to it, unlike therian mammals. While it still needs to be determined how an odour signal could be further processed in the brain, this study suggests that marsupials and monotremes possess well enough developed olfactory systems to be able to detect an odour cue from the mammary area at birth/hatching. It is therefore likely that neonate marsupials and newly hatched monotremes find their way to the milk source using olfactory cues, as has been previously suggested for the

  18. The development of the olfactory organs in newly hatched monotremes and neonate marsupials

    PubMed Central

    Schneider, Nanette Yvette

    2011-01-01

    Olfactory cues are thought to play a crucial role in the detection of the milk source at birth in mammals. It has been shown that a marsupial, the tammar wallaby, can detect olfactory cues from its mother's pouch at birth. This study investigates whether the main olfactory and accessory olfactory system are similarly well developed in other marsupials and monotremes at birth/hatching as in the tammar. Sections of the head of various marsupial and two monotreme species were investigated by light microscopy. Both olfactory systems were less well developed in the kowari and Eastern quoll. No olfactory or vomeronasal or terminal nerves could be observed; the main olfactory bulb (MOB) had only two layers while no accessory olfactory bulb or ganglion terminale were visible. All other investigated marsupials and monotremes showed further developed olfactory systems with olfactory, vomeronasal and terminal nerves, a three-layered MOB, and in the marsupials a prominent ganglion terminale. The main olfactory system was further developed than the accessory olfactory system in all species investigated. The olfactory systems were the least developed in species in which the mother's birth position removed most of the difficulty in reaching the teat, placing the neonate directly in the pouch. In monotremes they were the furthest developed as Bowman glands were found underlying the main olfactory epithelium. This may reflect the need to locate the milk field each time they drink as they cannot permanently attach to it, unlike therian mammals. While it still needs to be determined how an odour signal could be further processed in the brain, this study suggests that marsupials and monotremes possess well enough developed olfactory systems to be able to detect an odour cue from the mammary area at birth/hatching. It is therefore likely that neonate marsupials and newly hatched monotremes find their way to the milk source using olfactory cues, as has been previously suggested for the

  19. Treatability and characterization of Natural Organic Matter (NOM) in South African waters using newly developed methods

    NASA Astrophysics Data System (ADS)

    Nkambule, T. I.; Krause, R. W. M.; Haarhoff, J.; Mamba, B. B.

    Managing the removal of Natural Organic Matter (NOM) or problematic components from water has become increasingly important. NOM is a heterogeneous mixture of organic compounds of human origin and derived from plant and microbial residues. The inadequate removal of NOM has a bearing on the capacity of the other treatment processes to remove organic micro-pollutants or inorganic species that may be present in the water. In addition the action of certain disinfection processes has been shown to lead to the formation of harmful disinfection by-products (DBPs). Owing to the complexity, in composition and structure, of NOM, the techniques currently employed for its characterization have a number of limitations, both in terms of quantification and removal of the NOM within short periods of time. The dissolved organic carbon (DOC), biodegradable dissolved organic carbon (BDOC) and Fluorescence Emission Excitation Matrices (FEEM) were used to characterize NOM from various water samples collected around South Africa. Characterization results gave an indication of the character of NOM present in all the water samples. FEEM and UV-Vis results indicated that most of the water samples were aromatic in nature, since they had high hydrophobic and humic acid-like materials content. Generally, the characterization data indicated a varying composition of NOM amongst the various sampling points. The polarity rapid assessment method (PRAM) was then employed as a rapid NOM characterization tool. The characterization under PRAM is based on preferential adsorption of dissolved organic matter (DOM) fractions onto solid phase extraction (SPE) sorbents. The PRAM also allows the separation of DOM into fractions by polarity, hence reducing the molecular heterogeneity of NOM and thus aiding the removal of specific NOM fractions from water. The PRAM provided a quick characterization of the NOM character. However, DOC quantification by the PRAM analysis was hindered by excessive carbon leaching

  20. Purification and Characterization of Haloalkaline, Organic Solvent Stable Xylanase from Newly Isolated Halophilic Bacterium-OKH

    PubMed Central

    Sanghvi, Gaurav; Jivrajani, Mehul; Patel, Nirav; Jivrajani, Heta; Bhaskara, Govinal Badiger; Patel, Shivani

    2014-01-01

    A novel, alkali-tolerant halophilic bacterium-OKH with an ability to produce extracellular halophilic, alkali-tolerant, organic solvent stable, and moderately thermostable xylanase was isolated from salt salterns of Mithapur region, Gujarat, India. Identification of the bacterium was done based upon biochemical tests and 16S rRNA sequence. Maximum xylanase production was achieved at pH 9.0 and 37°C temperature in the medium containing 15% NaCl and 1% (w/v) corn cobs. Sugarcane bagasse and wheat straw also induce xylanase production when used as carbon source. The enzyme was active over a range of 0–25% sodium chloride examined in culture broth. The optimum xylanase activity was observed at 5% sodium chloride. Xylanase was purified with 25.81%-fold purification and 17.1% yield. Kinetic properties such as Km and Vmax were 4.2 mg/mL and 0.31 μmol/min/mL, respectively. The enzyme was stable at pH 6.0 and 50°C with 60% activity after 8 hours of incubation. Enzyme activity was enhanced by Ca2+, Mn2+, and Mg2+ but strongly inhibited by heavy metals such as Hg2+, Fe3+, Ni2+, and Zn2+. Xylanase was found to be stable in organic solvents like glutaraldehyde and isopropanol. The purified enzyme hydrolysed lignocellulosic substrates. Xylanase, purified from the halophilic bacterium-OKH, has potential biotechnological applications. PMID:27350996

  1. Purification and characterization of organic solvent stable serine alkaline protease from newly isolated Bacillus circulans M34.

    PubMed

    Sari, Esma; Loğoğlu, Elif; Öktemer, Atilla

    2015-09-01

    A protease from newly isolated Bacillus circulans M34 was purified by Q-Sepharose anion exchange chromatography and Sepharose-bacitracin affinity chromatography followed by (NH4)2SO4 precipitation. The molecular mass of the purified enzyme was determined using SDS-PAGE. The optimum pH and temperature for protease activity were 11 and 50°C, respectively. The effect of various metal ions on protease activity was investigated. Alkaline protease from Bacillus circulans M34 wase activated by Zn(2+), Cu(2+) and Co(2+) up to 31%. The purified protease was found to be stable in the organic solvents, surfactants and oxidizing agent. The substrate specificity of purified protease was investigated towards different substrates. The protease was almost completely inhibited by the serine protease inhibitor phenylmethanesulfonyl fluoride. The kinetic parameters of the purified protease, maximum rate (Vmax) and Michaelis constant (Km), were determined using a Lineweaver-Burk plot. PMID:25677873

  2. Characterisation of clinical and newly fabricated meshes for pelvic organ prolapse repair.

    PubMed

    Edwards, Sharon L; Werkmeister, Jerome A; Rosamilia, Anna; Ramshaw, John A M; White, Jacinta F; Gargett, Caroline E

    2013-07-01

    Clinical meshes used in pelvic organ prolapse (POP) repair are predominantly manufactured from monofilament polypropylene (PP). Complications from the use of these meshes in transvaginal kits, including mesh exposure and pain, have prompted two public health notifications by the FDA. The aim of this study was to compare several clinical PP POP meshes to new fabricated POP meshes, knitted from alternative polymers, for their mechanical properties using standard and clinically relevant multi-axial testing methods. Five new meshes were warp knitted to different architectures and weights from polyamide and polyetheretherketone monofilaments. A composite mesh of a polyamide mesh incorporating a gelatin layer was also fabricated to enable the potential delivery of cells on these meshes. Meshes were assessed for their structural characteristics and mechanical properties, using uniaxial stiffness, permanent strain, bending rigidity and multi-axial burst strength methods. Results were compared to three clinical urogynaecological polypropylene meshes: Polyform®, Gynemesh(TM)PS, and IntePro®. New fabricated meshes were uniaxially less stiff (less than 0.24 N/mm and 1.20 N/mm in toe and linear regions, respectively) than the Gynemesh (0.48 N/mm and 2.08 N/mm in toe and linear regions, respectively) and IntePro (0.57 N/mm in toe region) clinical meshes, with the gelatin coated PA mesh exhibiting lower permanent strain than Polyform clinical mesh (8.1% vs. 23.5%). New meshes had lower burst stiffness than Polyform (less than 16.9 N/mm for new meshes and 26.6N/mm for Polyform). Within the new mesh prototypes, the PA meshes, either uncoated (4.7-5.7 μN m) or with gelatin coating (16.7 μN m) possessed lower bending rigidity than both Polyform and Gynemesh (46.2 μN m and 36.4 μN m, respectively). The new fabricated mesh designs were of similar architecture, but with some improved mechanical properties, compared to clinical POP meshes. Multi-axial analysis of new and clinical

  3. Newly Diagnosed?

    MedlinePlus

    ... Suggestions Examine Your Skin Newly Diagnosed? Understanding Your Pathology Biopsy: The First Step Sentinel Node Biopsy Melanoma ... start this journey: Get a copy of your pathology report. We can help you understand the report ...

  4. Volatile organic compound concentrations, emission rates, and source apportionment in newly-built apartments at pre-occupancy stage.

    PubMed

    Shin, Seung H; Jo, Wan K

    2012-10-01

    The present study investigated the indoor concentrations of selected volatile organic compounds (VOCs) and formaldehyde and their indoor emission characteristics in newly-built apartments at the pre-occupancy stage. In total, 107 apartments were surveyed for indoor and outdoor VOC concentrations in two metropolitan cities and one rural area in Korea. A mass balanced model was used to estimate surface area-specific emission rates of individual VOCs and formaldehyde. Seven (benzene, ethyl benzene, toluene, m,p-xylene, o-xylene, n-hexane, and n-heptane) of 40 target compounds were detectable in all indoor air samples, whereas the first five were detected in all outdoor air samples. Formaldehyde was also predominant in the indoor air samples, with a high detection frequency of 96%. The indoor concentrations were significantly higher than the outdoor concentrations for aromatics, alcohols, terpenes, and ketones. However, six halogenated VOCs exhibited similar concentrations for indoor and outdoor air samples, suggesting that they are not major components emitted from building materials. It was also suggested that a certain portion of the apartments surveyed were constructed by not following the Korean Ministry of Environment guidelines for formaldehyde emissions. Toluene exhibited the highest emission rate with a median value of 138 μg m(-2) h(-1). The target compounds with median emission rates greater than 20 μg m(-2) h(-1) were toluene, 1-propanol, formaldehyde, and 2-butanone. The wood panels/vinyl floor coverings were the largest indoor pollutant source, followed by floorings, wall coverings, adhesives, and paints. The wood panels/vinyl floor coverings contributed nearly three times more to indoor VOC concentrations than paints. PMID:22698369

  5. How Newcomers Learn the Social Norms of an Organization: A Case Study of the Socialization of Newly Hired Engineers

    ERIC Educational Resources Information Center

    Korte, Russell F.

    2009-01-01

    Current scholarship views organizational socialization as a learning process that is primarily the responsibility of the newcomer. Yet recent learning research recognizes the importance of the social interactions in the learning process. This study investigated how newly hired engineers at a large manufacturing company learned job-related tasks…

  6. Orchard floor management effects on nitrogen fertility and soil biological activity in a newly established organic apple orchard

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Nutrient supply in organic systems is dependent on mineralization of organic matter; however, the intensive cultivation commonly used to control weeds can disrupt biological processes and cause undue loss of organic matter. Here we address the often-competing goals of organic fertility and weed con...

  7. Dynamic Escherichia coli SeqA complexes organize the newly replicated DNA at a considerable distance from the replisome

    PubMed Central

    Helgesen, Emily; Fossum-Raunehaug, Solveig; Sætre, Frank; Schink, Kay Oliver; Skarstad, Kirsten

    2015-01-01

    The Escherichia coli SeqA protein binds to newly replicated, hemimethylated DNA behind replication forks and forms structures consisting of several hundred SeqA molecules bound to about 100 kb of DNA. It has been suggested that SeqA structures either direct the new sister DNA molecules away from each other or constitute a spacer that keeps the sisters together. We have developed an image analysis script that automatically measures the distance between neighboring foci in cells. Using this tool as well as direct stochastic optical reconstruction microscopy (dSTORM) we find that in cells with fluorescently tagged SeqA and replisome the sister SeqA structures were situated close together (less than about 30 nm apart) and relatively far from the replisome (on average 200–300 nm). The results support the idea that newly replicated sister molecules are kept together behind the fork and suggest the existence of a stretch of DNA between the replisome and SeqA which enjoys added stabilization. This could be important in facilitating DNA transactions such as recombination, mismatch repair and topoisomerase activity. In slowly growing cells without ongoing replication forks the SeqA protein was found to reside at the fully methylated origins prior to initiation of replication. PMID:25722374

  8. Impact of floor management strategies on nitrogen fertility and biological soil quality in newly established organic apple orchards

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Sustainable methods of nitrogen (N) fertility and weed management are a challenge in organic orchard management systems. Nutrient supply is dependent on decomposition and mineralization of organic matter, yet intensive cultivation commonly used to control weeds can disrupt biological processes cont...

  9. Cazymes Analysis Toolkit (CAT): Webservice for searching and analyzing carbohydrateactive enzymes in a newly sequenced organism using CAZy database

    SciTech Connect

    Karpinets, Tatiana V; Park, Byung; Syed, Mustafa H; Uberbacher, Edward C; Leuze, Michael Rex

    2010-01-01

    The Carbohydrate-Active Enzyme (CAZy) database provides a rich set of manually annotated enzymes that degrade, modify, or create glycosidic bonds. Despite rich and invaluable information stored in the database, software tools utilizing this information for annotation of newly sequenced genomes by CAZy families are limited. We have employed two annotation approaches to fill the gap between manually curated high-quality protein sequences collected in the CAZy database and the growing number of other protein sequences produced by genome or metagenome sequencing projects. The first approach is based on a similarity search against the entire non-redundant sequences of the CAZy database. The second approach performs annotation using links or correspondences between the CAZy families and protein family domains. The links were discovered using the association rule learning algorithm applied to sequences from the CAZy database. The approaches complement each other and in combination achieved high specificity and sensitivity when cross-evaluated with the manually curated genomes of Clostridium thermocellum ATCC 27405 and Saccharophagus degradans 2-40. The capability of the proposed framework to predict the function of unknown protein domains (DUF) and of hypothetical proteins in the genome of Neurospora crassa is demonstrated. The framework is implemented as a Web service, the CAZymes Analysis Toolkit (CAT), and is available at http://cricket.ornl.gov/cgi-bin/cat.cgi.

  10. Inorganic nitrogen leaching from organic and conventional rice production on a newly claimed calciustoll in Central Asia.

    PubMed

    Meng, Fanqiao; Olesen, Jørgen E; Sun, Xiangping; Wu, Wenliang

    2014-01-01

    Characterizing the dynamics of nitrogen (N) leaching from organic and conventional paddy fields is necessary to optimize fertilization and to evaluate the impact of these contrasting farming systems on water bodies. We assessed N leaching in organic versus conventional rice production systems of the Ili River Valley, a representative aquatic ecosystem of Central Asia. The N leaching and overall performance of these systems were measured during 2009, using a randomized block experiment with five treatments. PVC pipes were installed at soil depths of 50 and 180 cm to collect percolation water from flooded organic and conventional paddies, and inorganic N (NH4-N+NO3-N) was analyzed. Two high-concentration peaks of NH4-N were observed in all treatments: one during early tillering and a second during flowering. A third peak at the mid-tillering stage was observed only under conventional fertilization. NO3-N concentrations were highest at transplant and then declined until harvest. At the 50 cm soil depth, NO3-N concentration was 21-42% higher than NH4-N in percolation water from organic paddies, while NH4-N and NO3-N concentrations were similar for the conventional and control treatments. At the depth of 180 cm, NH4-N and NO3-N were the predominant inorganic N for organic and conventional paddies, respectively. Inorganic N concentrations decreased with soil depth, but this attenuation was more marked in organic than in conventional paddies. Conventional paddies leached a higher percentage of applied N (0.78%) than did organic treatments (0.32-0.60%), but the two farming systems leached a similar amount of inorganic N per unit yield (0.21-0.34 kg N Mg(-1) rice grains). Conventional production showed higher N utilization efficiency compared to fertilized organic treatments. These results suggest that organic rice production in the Ili River Valley is unlikely to reduce inorganic N leaching, if high crop yields similar to conventional rice production are to be maintained

  11. Tracking the monthly changes of dissolved organic matter composition in a newly constructed reservoir and its tributaries during the initial impounding period.

    PubMed

    Chen, Meilian; He, Wei; Choi, Ilhwan; Hur, Jin

    2016-01-01

    Understanding the roles of inland reservoirs becomes increasingly important with respect to global carbon cycling as well as water resource management due to the unprecedented demand for construction in recent decades. In this study, the dissolved organic matter (DOM) quantity and quality in a newly constructed dam reservoir and its tributaries were monitored monthly during the initial impounding period (July to November 2014) using a size exclusion chromatography (SEC) with online organic carbon detector (OCD). The highest values were observed in the month of August with the highest precipitation for the bulk dissolved organic carbon (DOC), specific UV absorbance (SUVA), and most of the assigned size fractions (except for biopolymers) in the tributaries, indicating that allochthonous sources of DOM were dominant in the feeding stream waters of the reservoir. The bulk DOC and high molecular weight humic substance fraction (∼1 kDa) were generally co-varied with the monthly precipitation in the tributaries, while building blocks (350-500 Da), and low molecular weight (LMW) acids and neutrals showed different trends. In a dam site, the smaller molecular fractions became more abundant during the dry season (September to November), presumably due to the in-reservoir processes such as photo- and bio-degradation. Our results also revealed that storms mobilized a large amount of highly aromatic soil-derived DOM to the reservoir. A depth profile at the dam site showed the water is well mixed up to a depth of ∼20 m. The SEC-OCD data coupled with non-metric multidimensional scaling provided a clear visualization of the spatiotemporal variations in DOM composition, which shed new light on the DOM composition formed in a newly constructed dam reservoir and also on the strategies for future water treatment options. PMID:26358212

  12. Organic aerosol components derived from 25 AMS datasets across Europe using a newly developed ME-2 based source apportionment strategy

    NASA Astrophysics Data System (ADS)

    Crippa, M.; Canonaco, F.; Lanz, V. A.; Äijälä, M.; Allan, J. D.; Carbone, S.; Capes, G.; Dall'Osto, M.; Day, D. A.; DeCarlo, P. F.; Di Marco, C. F.; Ehn, M.; Eriksson, A.; Freney, E.; Hildebrandt Ruiz, L.; Hillamo, R.; Jimenez, J.-L.; Junninen, H.; Kiendler-Scharr, A.; Kortelainen, A.-M.; Kulmala, M.; Mensah, A. A.; Mohr, C.; Nemitz, E.; O'Dowd, C.; Ovadnevaite, J.; Pandis, S. N.; Petäjä, T.; Poulain, L.; Saarikoski, S.; Sellegri, K.; Swietlicki, E.; Tiitta, P.; Worsnop, D. R.; Baltensperger, U.; Prévôt, A. S. H.

    2013-09-01

    Organic aerosols (OA) represent one of the major constituents of submicron particulate matter (PM1) and comprise a huge variety of compounds emitted by different sources. Three intensive measurement field campaigns to investigate the aerosol chemical composition all over Europe were carried out within the framework of EUCAARI and the intensive campaigns of EMEP during 2008 (May-June and September-October) and 2009 (February-March). In this paper we focus on the identification of the main organic aerosol sources and we propose a standardized methodology to perform source apportionment using positive matrix factorization (PMF) with the multilinear engine (ME-2) on Aerodyne aerosol mass spectrometer (AMS) data. Our source apportionment procedure is tested and applied on 25 datasets accounting for urban, rural, remote and high altitude sites and therefore it is likely suitable for the treatment of AMS-related ambient datasets. For most of the sites, four organic components are retrieved, improving significantly previous source apportionment results where only a separation in primary and secondary OA sources was possible. Our solutions include two primary OA sources, i.e. hydrocarbon-like OA (HOA) and biomass burning OA (BBOA) and two secondary OA components, i.e. semi-volatile oxygenated OA (SV-OOA) and low-volatility oxygenated OA (LV-OOA). For specific sites cooking-related (COA) and marine-related sources (MSA) are also separated. Finally, our work provides a large overview of organic aerosol sources in Europe and an interesting set of highly time resolved data for modeling evaluation purposes.

  13. Compound-specific 15N analysis of amino acids in 15N tracer experiments provide an estimate of newly synthesised soil protein from inorganic and organic substrates

    NASA Astrophysics Data System (ADS)

    Charteris, Alice; Michaelides, Katerina; Evershed, Richard

    2015-04-01

    Organic N concentrations far exceed those of inorganic N in most soils and despite much investigation, the composition and cycling of this complex pool of SOM remains poorly understood. A particular problem has been separating more recalcitrant soil organic N from that actively cycling through the soil system; an important consideration in N cycling studies and for the soil's nutrient supplying capacity. The use of 15N-labelled substrates as stable isotope tracers has contributed much to our understanding of the soil system, but the complexity and heterogeneity of soil organic N prevents thorough compound-specific 15N analyses of organic N compounds and makes it difficult to examine any 15N-labelled organic products in any detail. As a result, a significant proportion of previous work has either simply assumed that since the majority of soil N is organic, all of the 15N retained in the soil is organic N (e.g. Sebilo et al., 2013) or subtracted 15N-labelled inorganic compounds from bulk values (e.g. Pilbeam et al., 1997). While the latter approach is more accurate, these methods only provide an estimate of the bulk 15N value of an extremely complex and non-uniformly labelled organic pool. A more detailed approach has been to use microbial biomass extraction (Brookes et al., 1985) and subsequent N isotopic analysis to determine the 15N value of biomass-N, representing the fraction of 15N assimilated by microbes or the 15N cycling through the 'living' or 'active' portion of soil organic N. However, this extraction method can only generate estimates and some lack of confidence in its validity and reliability remains. Here, we present an alternative technique to obtain a measure of the assimilation of an applied 15N substrate by the soil microbial biomass and an estimate of the newly synthesized soil protein, which is representative of the magnitude of the active soil microbial biomass. The technique uses a stable isotope tracer and compound-specific 15N analysis, but

  14. Fission product retention in newly discovered organic-rich natural fission reactors at Oklo and Bangombe, Gabon

    SciTech Connect

    Nagy, B.; Rigali, M.J. )

    1993-01-01

    The discovery of naturally occurring fission reactors in the rock strata of the Paleoproterozoic Francevillian Basin in the Republic of Gabon in equatorial West Africa led to several programs to define migration and/or retention of uranium and fissiogenic isotopes from/in the natural reactor zones. Although much understanding has been gained, new insight is needed regarding the chemical and physical parameters that control movement and retention of fission products over almost two billion years from/in the natural reactors. Seventeen known natural fission reactors sustained criticality for 0.1 to 1 million years in hydrothermally altered sedimentary rocks 1968 +/- 50 million years ago. These natural nuclear reactors attained criticality because of high concentrations of uranium in small pockets in uranium ores, the lack of neutron poisons, and because at the time they reached criticality, the abundance of [sup 235]U was five times greater than it is today. Water acted as a moderator, and temperature in the natural reactors was between 160 and 360[degrees]C. Both the uranium-rich pockets and the uranium ore bodies in which these pockets are located were formed when aqueous solutions moving through highly fractured zones in the Francevillian sedimentary rocks met organic-rich sediments. This resulted in the reduction of U(VI) in the dissolved uranyl ions to U(IV), causing the precipitation of pitchblende and uraninite. It has been proposed that between 2.2 and 1.9 billion years ago, the earth's atmosphere experienced a remarkable temporary rise in O[sub 2] content; this event may account for the uranium-bearing, oxidizing aqueous solutions in the Francevillian rocks.

  15. Temporal dynamics of the carbon isotope composition in a Pinus sylvestris stand: from newly assimilated organic carbon to respired carbon dioxide.

    PubMed

    Kodama, Naomi; Barnard, Romain L; Salmon, Yann; Weston, Christopher; Ferrio, Juan Pedro; Holst, Jutta; Werner, Roland A; Saurer, Matthias; Rennenberg, Heinz; Buchmann, Nina; Gessler, Arthur

    2008-07-01

    The (13)C isotopic signature (C stable isotope ratio; delta(13)C) of CO(2) respired from forest ecosystems and their particular compartments are known to be influenced by temporal changes in environmental conditions affecting C isotope fractionation during photosynthesis. Whereas most studies have assessed temporal variation in delta(13)C of ecosystem-respired CO(2) on a day-to-day scale, not much information is available on its diel dynamics. We investigated environmental and physiological controls over potential temporal changes in delta(13)C of respired CO(2) by following the short-term dynamics of the (13)C signature from newly assimilated organic matter pools in the needles, via phloem-transported organic matter in twigs and trunks, to trunk-, soil- and ecosystem-respired CO(2). We found a strong 24-h periodicity in delta(13)C of organic matter in leaf and twig phloem sap, which was strongly dampened as carbohydrates were transported down the trunk. Periodicity reappeared in the delta(13)C of trunk-respired CO(2), which seemed to originate from apparent respiratory fractionation rather than from changes in delta(13)C of the organic substrate. The diel patterns of delta(13)C in soil-respired CO(2) are partly explained by soil temperature and moisture and are probably due to changes in the relative contribution of heterotrophic and autotrophic CO(2) fluxes to total soil efflux in response to environmental conditions. Our study shows that direct relations between delta(13)C of recent assimilates and respired CO(2) may not be present on a diel time scale, and other factors lead to short-term variations in delta(13)C of ecosystem-emitted CO(2). On the one hand, these variations complicate ecosystem CO(2) flux partitioning, but on the other hand they provide new insights into metabolic processes underlying respiratory CO(2) emission. PMID:18392642

  16. Integral Reactor Physics Benchmarks - the International Criticality Safety Benchmark Evaluation Project (icsbep) and the International Reactor Physics Experiment Evaluation Project (irphep)

    NASA Astrophysics Data System (ADS)

    Briggs, J. Blair; Nigg, David W.; Sartori, Enrico

    2006-04-01

    Since the beginning of the nuclear industry, thousands of integral experiments related to reactor physics and criticality safety have been performed. Many of these experiments can be used as benchmarks for validation of calculational techniques and improvements to nuclear data. However, many were performed in direct support of operations and thus were not performed with a high degree of quality assurance and were not well documented. For years, common validation practice included the tedious process of researching integral experiment data scattered throughout journals, transactions, reports, and logbooks. Two projects have been established to help streamline the validation process and preserve valuable integral data: the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and the International Reactor Physics Experiment Evaluation Project (IRPhEP). The two projects are closely coordinated to avoid duplication of effort and to leverage limited resources to achieve a common goal. A short history of these two projects and their common purpose are discussed in this paper. Accomplishments of the ICSBEP are highlighted and the future of the two projects outlined.

  17. Evaluation of Volatile Organic Compounds and Carbonyl Compounds Present in the Cabins of Newly Produced, Medium- and Large-Size Coaches in China

    PubMed Central

    Lu, Yan-Yang; Lin, Yi; Zhang, Han; Ding, Dongxiao; Sun, Xia; Huang, Qiansheng; Lin, Lifeng; Chen, Ya-Jie; Chi, Yu-Lang; Dong, Sijun

    2016-01-01

    An air-conditioned coach is an important form of transportation in modern motorized society; as a result, there is an increasing concern of in-vehicle air pollution. In this study, we aimed to identify and quantify the levels of volatile organic compounds (VOCs) and carbonyl compounds (CCs) in air samples collected from the cabins of newly produced, medium- and large-size coaches. Among the identified VOCs and CCs, toluene, ethylbenzene, xylene, formaldehyde, acetaldehyde, acrolein/acetone, and isovaleraldehyde were relatively abundant in the cabins. Time was found to affect the emissions of the contaminants in the coaches. Except for benzaldehyde, valeraldehyde and benzene, the highest in-vehicle concentrations of VOCs and CCs were observed on the 15th day after coming off the assembly line, and the concentrations exhibited an approximately inverted U-shaped pattern as a function of time. Interestingly, this study also showed that the interior temperature of the coaches significantly affected the VOCs emissions from the interior materials, whereas the levels of CCs were mainly influenced by the relative humidity within the coaches. In China, guidelines and regulations for the in-vehicle air quality assessment of the coaches have not yet been issued. The results of this study provide further understanding of the in-vehicle air quality of air-conditioned coaches and can be used in the development of both specific and general rules regarding medium- and large-size coaches. PMID:27314375

  18. Evaluation of Volatile Organic Compounds and Carbonyl Compounds Present in the Cabins of Newly Produced, Medium- and Large-Size Coaches in China.

    PubMed

    Lu, Yan-Yang; Lin, Yi; Zhang, Han; Ding, Dongxiao; Sun, Xia; Huang, Qiansheng; Lin, Lifeng; Chen, Ya-Jie; Chi, Yu-Lang; Dong, Sijun

    2016-01-01

    An air-conditioned coach is an important form of transportation in modern motorized society; as a result, there is an increasing concern of in-vehicle air pollution. In this study, we aimed to identify and quantify the levels of volatile organic compounds (VOCs) and carbonyl compounds (CCs) in air samples collected from the cabins of newly produced, medium- and large-size coaches. Among the identified VOCs and CCs, toluene, ethylbenzene, xylene, formaldehyde, acetaldehyde, acrolein/acetone, and isovaleraldehyde were relatively abundant in the cabins. Time was found to affect the emissions of the contaminants in the coaches. Except for benzaldehyde, valeraldehyde and benzene, the highest in-vehicle concentrations of VOCs and CCs were observed on the 15th day after coming off the assembly line, and the concentrations exhibited an approximately inverted U-shaped pattern as a function of time. Interestingly, this study also showed that the interior temperature of the coaches significantly affected the VOCs emissions from the interior materials, whereas the levels of CCs were mainly influenced by the relative humidity within the coaches. In China, guidelines and regulations for the in-vehicle air quality assessment of the coaches have not yet been issued. The results of this study provide further understanding of the in-vehicle air quality of air-conditioned coaches and can be used in the development of both specific and general rules regarding medium- and large-size coaches. PMID:27314375

  19. Short-Chain Flavor Ester Synthesis in Organic Media by an E. coli Whole-Cell Biocatalyst Expressing a Newly Characterized Heterologous Lipase

    PubMed Central

    Brault, Guillaume; Shareck, François; Hurtubise, Yves; Lépine, François; Doucet, Nicolas

    2014-01-01

    Short-chain aliphatic esters are small volatile molecules that produce fruity and pleasant aromas and flavors. Most of these esters are artificially produced or extracted from natural sources at high cost. It is, however, possible to ‘naturally’ produce these molecules using biocatalysts such as lipases and esterases. A gene coding for a newly uncovered lipase was isolated from a previous metagenomic study and cloned into E. coli BL21 (DE3) for overexpression using the pET16b plasmid. Using this recombinant strain as a whole-cell biocatalyst, short chain esters were efficiently synthesized by transesterification and esterification reactions in organic media. The recombinant lipase (LipIAF5-2) showed good affinity toward glyceryl trioctanoate and the highest conversion yields were obtained for the transesterification of glyceryl triacetate with methanol. Using a simple cetyl-trimethylammonium bromide pretreatment increased the synthetic activity by a six-fold factor and the whole-cell biocatalyst showed the highest activity at 40°C with a relatively high water content of 10% (w/w). The whole-cell biocatalyst showed excellent tolerance to alcohol and short-chain fatty acid denaturation. Substrate affinity was equally effective with all primary alcohols tested as acyl acceptors, with a slight preference for methanol. The best transesterification conversion of 50 mmol glyceryl triacetate into isoamyl acetate (banana fragrance) provided near 100% yield after 24 hours using 10% biocatalyst loading (w/w) in a fluidized bed reactor, allowing recycling of the biocatalyst up to five times. These results show promising potential for an industrial approach aimed at the biosynthesis of short-chain esters, namely for natural flavor and fragrance production in micro-aqueous media. PMID:24670408

  20. How Newcomers Learn the Social Norms of an Organization: A Case Study of the Socialization of Newly Hired Engineers. Research Brief

    ERIC Educational Resources Information Center

    Korte, Russel

    2009-01-01

    Current scholarship views organizational socialization as a learning process that is primarily the responsibility of the newcomer. Yet recent learning research recognizes the importance of the social interactions in the learning process. This study investigated how newly hired engineers at a large manufacturing company learned job-related tasks…

  1. CAZymes Analysis Toolkit (CAT): web service for searching and analyzing carbohydrate-active enzymes in a newly sequenced organism using CAZy database.

    PubMed

    Park, Byung H; Karpinets, Tatiana V; Syed, Mustafa H; Leuze, Michael R; Uberbacher, Edward C

    2010-12-01

    The Carbohydrate-Active Enzyme (CAZy) database provides a rich set of manually annotated enzymes that degrade, modify, or create glycosidic bonds. Despite rich and invaluable information stored in the database, software tools utilizing this information for annotation of newly sequenced genomes by CAZy families are limited. We have employed two annotation approaches to fill the gap between manually curated high-quality protein sequences collected in the CAZy database and the growing number of other protein sequences produced by genome or metagenome sequencing projects. The first approach is based on a similarity search against the entire nonredundant sequences of the CAZy database. The second approach performs annotation using links or correspondences between the CAZy families and protein family domains. The links were discovered using the association rule learning algorithm applied to sequences from the CAZy database. The approaches complement each other and in combination achieved high specificity and sensitivity when cross-evaluated with the manually curated genomes of Clostridium thermocellum ATCC 27405 and Saccharophagus degradans 2-40. The capability of the proposed framework to predict the function of unknown protein domains and of hypothetical proteins in the genome of Neurospora crassa is demonstrated. The framework is implemented as a Web service, the CAZymes Analysis Toolkit, and is available at http://cricket.ornl.gov/cgi-bin/cat.cgi. PMID:20696711

  2. Generational differences among newly licensed registered nurses.

    PubMed

    Keepnews, David M; Brewer, Carol S; Kovner, Christine T; Shin, Juh Hyun

    2010-01-01

    Responses of 2369 newly licensed registered nurses from 3 generational cohorts-Baby Boomers, Generation X, and Generation Y-were studied to identify differences in their characteristics, work-related experiences, and attitudes. These responses revealed significant differences among generations in: job satisfaction, organizational commitment, work motivation, work-to-family conflict, family-to-work conflict, distributive justice, promotional opportunities, supervisory support, mentor support, procedural justice, and perceptions of local job opportunities. Health organizations and their leaders need to anticipate intergenerational differences among newly licensed nurses and should provide for supportive working environments that recognize those differences. Orientation and residency programs for newly licensed nurses should be tailored to the varying needs of different generations. Future research should focus on evaluating the effectiveness of orientation and residency programs with regard to different generations so that these programs can be tailored to meet the varying needs of newly licensed nurses at the start of their careers. PMID:20494691

  3. Corrosion inhibition of mild steel in acidic media using newly synthesized heterocyclic organic molecules: Correlation between inhibition efficiency and chemical structure

    NASA Astrophysics Data System (ADS)

    Ouici, H. B.; Benali, O.; Guendouzi, A.

    2015-03-01

    The corrosion inhibition of mild steel in 5% HCl solutions by some new synthesized organic compounds namely 3-(2-methoxyphenyl) 5-mercapto-1. 2. 4-triazole (2-MMT), 3-(3-methoxyphenyl) 5-mercapto-1. 2. 4-triazole (3-MMT) and 3-(2-hydroxyphenyl) 5-mercapto-1. 2. 4-triazole (2-HMT) was investigated using weight loss and potentiostatic polarization techniques. These measurements reveal that the inhibition efficiency obtained by these compounds increased by increasing their concentration. The inhibition efficiency follows the order 2-MMT >3-MMT >2-HMT. Polarization studies show that these compounds are of the mixed type but dominantly act as a cathodic inhibitors for mild steel in 5% HCl solutions. These inhibitors function through adsorption following Langmuir isotherm. Activation energy and Gibbs free energy for adsorption of inhibitors are calculated. Molecular modeling has been conducted to correlate the corrosion inhibition properties with the calculated quantum chemical parameters.

  4. Corrosion inhibition of mild steel in acidic media using newly synthesized heterocyclic organic molecules: Correlation between inhibition efficiency and chemical structure

    SciTech Connect

    Ouici, H. B. Guendouzi, A.; Benali, O.

    2015-03-30

    The corrosion inhibition of mild steel in 5% HCl solutions by some new synthesized organic compounds namely 3-(2-methoxyphenyl) 5-mercapto-1. 2. 4-triazole (2-MMT), 3-(3-methoxyphenyl) 5-mercapto-1. 2. 4-triazole (3-MMT) and 3-(2-hydroxyphenyl) 5-mercapto-1. 2. 4-triazole (2-HMT) was investigated using weight loss and potentiostatic polarization techniques. These measurements reveal that the inhibition efficiency obtained by these compounds increased by increasing their concentration. The inhibition efficiency follows the order 2-MMT >3-MMT >2-HMT. Polarization studies show that these compounds are of the mixed type but dominantly act as a cathodic inhibitors for mild steel in 5% HCl solutions. These inhibitors function through adsorption following Langmuir isotherm. Activation energy and Gibbs free energy for adsorption of inhibitors are calculated. Molecular modeling has been conducted to correlate the corrosion inhibition properties with the calculated quantum chemical parameters.

  5. An organic solvent-stable lipase from a newly isolated Staphylococcus aureus ALA1 strain with potential for use as an industrial biocatalyst.

    PubMed

    Ben Bacha, Abir; Moubayed, Nadine Ms; Al-Assaf, Alaa

    2016-05-01

    In this study, a new strain, ALA1, was identified as Staphylococcus aureus by biochemical tests, and its 16S ribosomal DNA sequence was isolated from dromedary milk. ALA1 lipase production was optimized in shake flask experiments and measured with varying pH (3-11), temperature (20-55 °C) and substrate concentrations. The maximum lipase production was recorded at pH 8 and 30 °C for up to 30 H of culture period for the S. aureus ALA1 strain. Among the substrates tested, selected carbon sources, xylose, nitrogen source, yeast extract, and olive oil (1%) were suitable for maximizing lipase production. The effects of surfactants were investigated and showed that Tween 20, Tween 80, and Triton X-100 prevented lipase production. Interestingly, isolate ALA1 was able to grow in high concentrations of benzene or toluene (up to 50% (v/v)). Moreover, the lipolytic activity of the S. aureus ALA1 lipase was stimulated by diethyl ether, whereas almost 100% of S. aureus ALA1 lipase activity was retained in 25% acetone, acetonitrile, benzene, 2-propanol, ethanol, methanol, or toluene. Because of its stability in organic solvent, the S. aureus ALA1 lipase was used as a biocatalyst to synthesize high levels of added value molecules. S. aureus ALA1 lipase could be considered as an ideal choice for applications in detergent formulations because of its high stability and compatibility with various surfactants, oxidizing agents, and commercial detergents. PMID:25828848

  6. Emission Rates of Volatile Organic Compounds Released from Newly Produced Household Furniture Products Using a Large-Scale Chamber Testing Method

    PubMed Central

    Ho, Duy Xuan; Kim, Ki-Hyun; Ryeul Sohn, Jong; Hee Oh, Youn; Ahn, Ji-Won

    2011-01-01

    The emission rates of volatile organic compounds (VOCs) were measured to investigate the emission characteristics of five types of common furniture products using a 5 m3 size chamber at 25°C and 50% humidity. The results indicated that toluene and α-pinene are the most dominant components. The emission rates of individual components decreased constantly through time, approaching the equilibrium emission level. The relative ordering of their emission rates, if assessed in terms of total VOC (TVOC), can be arranged as follows: dining table > sofa > desk chair > bedside table > cabinet. If the emission rates of VOCs are examined between different chemical groups, they can also be arranged in the following order: aromatic (AR) > terpenes (TER) > carbonyl (CBN) > others > paraffin (PR) > olefin (HOL) > halogenated paraffin (HPR). In addition, if emission strengths are compared between coated and uncoated furniture, there is no significant difference in terms of emission magnitude. Our results indicate that the emission characteristics of VOC are greatly distinguished between different furniture products in terms of relative dominance between different chemicals. PMID:22125421

  7. Understanding Prostate Cancer: Newly Diagnosed

    MedlinePlus

    ... Wellness PCF Spotlight Glossary African American Men Understanding Prostate Cancer Newly Diagnosed Newly Diagnosed Staging the Disease Issues ... you care about has recently been diagnosed with prostate cancer, this section will help guide you through the ...

  8. Newly Deployed Sojourner Rover

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This 8-image mosaic was acquired during the late afternoon (near 5pm LST, note the long shadows) on Sol 2 as part of the predeploy 'insurance panorama' and shows the newly deployed rover sitting on the Martian surface. This color image was generated from images acquired at 530,600, and 750 nm. The insurance panorama was designed as 'insurance' against camera failure upon deployment. Had the camera failed, the losslessly-compressed, multispectral insurance panorama would have been the main source of image data from the IMP.

    However, the camera deployment was successful, leaving the insurance panorama to be downlinked to Earth several weeks later. Ironically enough, the insurance panorama contains some of the best quality image data because of the lossless data compression and relatively dust-free state of the camera and associated lander/rover hardware on Sol 2.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal investigator.

  9. Newly discovered quick, non-invasive screening method of bone marrow malignancies including various leukemias, Hodgkin's lymphoma, non-Hodgkin's lymphoma, & multiple myeloma by abnormality of small rectangular area within bone marrow organ representation areas of the face.

    PubMed

    Omura, Yoshiaki; O'Young, Brian; Jones, Marilyn; Nihrane, Abdalla; Duvvi, Harsha; Paluch, Kamila; Shimotsuura, Yasuhiro; Ohki, Motomu

    2012-01-01

    Diagnoses of bone marrow associated malignancies such as Acute & Chronic Lymphocytic Leukemia, Acute & Chronic Myelogenous (Myeloid) Leukemia, Hodgkin's Lymphoma & Non-Hodgkin's Lymphoma, and Multiple Myeloma are often missed without a blood test. However, in 2008, Omura Y reported several newly discovered organ representation areas that exist between the lower end of the eyebrows and upper end of the upper eyelid. This space was divided into 5 organ representation areas. The first space (more than 1/4 of entire space) near the side of the face (temple) is the bone marrow representation area (BMRA). Therefore, we examined the bone marrow representation areas non-invasively using the Bi-Digital O-Ring Test (BDORT). When the small rectangular shaped part of the BMRA is strong negative (-) with more than -2, often there is a malignancy associated with bone marrow. In this area, we found 1) Integrin alpha5beta1 & Oncogen C-fos Ab2 increased very significantly between 125-300 ng BDORT units; 2) very high Chrysotile Asbestos (0.11-0.14 mg); 3) markedly reduced Acetylcholine of less than 1 ng; 4) significantly reduced telomere of less than 1 yg (= 10(-24) g); and 5) Increased 8-OH-dG (often more than 5 ng). Once the abnormal small rectangular area is localized by BDORT, by detecting the specific microscope slide which produces EMF (electromagnetic field) resonance, one can diagnose these malignancies non-invasively in about 10 minutes. When a subject has any one of the above 7 types of bone marrow associated malignancies, the 5 aforementioned abnormal parameters can be detected. When Acetylcholine is markedly reduced to 0.25 ng or less, 8-OH-dG is 10 ng or higher, and Sirtuin 1 (one of the 7 mammalian longevity genes products) in both the Hippocampus and the body is 0.025 pg or less, most of the patients have a very poor prognosis. However, we found that increasing normal cell telomere & longevity gene product Sirtuin 1 can often improve both pathology & prognosis. All

  10. Impact of weed barriers on newly planted peach trees

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Newly planted (Feb. 2005) ‘Sunracer’ and ‘Sunhome’ nectarine and ‘Tropic Snow’ peach (Prunus persica (L.) Batsch) trees were subjected to conventional and four 'organic' weed control methods. Two of the 'organic' methods used weed barriers of white plastic (WP) or landscape fabric (LF). A third co...

  11. Chthonomonas calidirosea gen. nov., sp. nov., an aerobic, pigmented, thermophilic micro-organism of a novel bacterial class, Chthonomonadetes classis nov., of the newly described phylum Armatimonadetes originally designated candidate division OP10.

    PubMed

    Lee, Kevin C-Y; Dunfield, Peter F; Morgan, Xochitl C; Crowe, Michelle A; Houghton, Karen M; Vyssotski, Mikhail; Ryan, Jason L J; Lagutin, Kirill; McDonald, Ian R; Stott, Matthew B

    2011-10-01

    An aerobic, saccharolytic, obligately thermophilic, motile, non-spore-forming bacterium, strain T49(T), was isolated from geothermally heated soil at Hell's Gate, Tikitere, New Zealand. On the basis of 16S rRNA gene sequence similarity, T49(T) is the first representative of a new class in the newly described phylum Armatimonadetes, formerly known as candidate division OP10. Cells of strain T49(T) stained Gram-negative and were catalase-positive and oxidase-negative. Cells possessed a highly corrugated outer membrane. The major fatty acids were 16 : 0, i17 : 0 and ai17 : 0. The G+C content of the genomic DNA was 54.6 mol%. Strain T49(T) grew at 50-73 °C with an optimum temperature of 68 °C, and at pH 4.7-5.8 with an optimum growth pH of 5.3. A growth rate of 0.012 h(-1) was observed under optimal temperature and pH conditions. The primary respiratory quinone was MK-8. Optimal growth was achieved in the absence of NaCl, although growth was observed at NaCl concentrations as high as 2 % (w/v). Strain T49(T) was able to utilize mono- and disaccharides such as cellobiose, lactose, mannose and glucose, as well as branched or amorphous polysaccharides such as starch, CM-cellulose, xylan and glycogen, but not highly linear polysaccharides such as crystalline cellulose or cotton. On the basis of its phylogenetic position and phenotypic characteristics, we propose that strain T49(T) represents a novel bacterial genus and species within the new class Chthonomonadetes classis nov. of the phylum Armatimonadetes. The type strain of Chthonomonas calidirosea gen. nov., sp. nov. is T49(T) ( = DSM 23976(T) = ICMP 18418(T)). PMID:21097641

  12. Organizations.

    ERIC Educational Resources Information Center

    Aviation/Space, 1980

    1980-01-01

    This is a list of aerospace organizations and other groups that provides educators with assistance and information in specific areas. Both government and nongovernment organizations are included. (Author/SA)

  13. Newly Installed S-1 Truss

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Launched October 7, 2002 aboard the Space Shuttle Orbiter Atlantis, the STS-112 mission lasted 11 days and performed three sessions of Extra Vehicular Activity (EVA). Its primary mission was to install the Starboard (S1) Integrated Truss Structure and Equipment Translation Aid (CETA) Cart to the International Space Station (ISS). The S1 truss provides structural support for the orbiting research facility's radiator panels, which use ammonia to cool the Station's complex power system. The S1 truss, attached to the S0 (S Zero) truss installed by the previous STS-110 mission, flows 637 pounds of anhydrous ammonia through three heat rejection radiators. The truss is 45-feet long, 15-feet wide, 10-feet tall, and weighs approximately 32,000 pounds. The CETA is the first of two human-powered carts that will ride along the International Space Station's railway providing a mobile work platform for future extravehicular activities by astronauts. This is a view of the newly installed S1 Truss as photographed during the mission's first scheduled EVA. The Station's Canadarm2 is in the foreground. Visible are astronauts Piers J. Sellers (lower left) and David A. Wolf (upper right), both STS-112 mission specialists.

  14. Newly Diagnosed Acute Promyelocytic Leukemia

    PubMed Central

    Avvisati, Giuseppe

    2011-01-01

    Acute promyelocytic leukemia (APL) represents a medical emergency with a high rate of early mortality. As a consequence, as soon as the diagnosis is suspected based upon cytologic criteria, it is necessary to start all- trans retinoic acid (ATRA) treatment without delay. For patients with newly diagnosed APL, induction therapy with ATRA plus anthracycline based chemotherapy is recommended. At present the combination of arsenic trioxide plus ATRA should be considered for patients who are not candidates for anthracycline-based therapy. For pediatric and adult patients with APL aged < 60 years who achieve a CR with induction, I recommend 3 intensive courses of consolidation chemotherapy associated to ATRA, targeted on the basis of the risk group at diagnosis. In patients treated with a very intensive consolidation chemotherapy maintenance treatment can be omitted. However If a maintenance treatment has to be adopted I suggest the use of intermittent ATRA for 15 days every 3 months for a period of 2 years, rather than ATRA associated to chemotherapy. Moreover, taking into account the medical literature, a reduced dosage of ATRA ( 25 mg/m2) in pediatric patients and a consolidation chemotherapy of reduced intensity in elderly patients is recommended. Furthermore, in order to maximize survival, careful attention should be reserved to the coagulopathy and to the appearance of the differentiation syndrome. Finally, PCR for the PML/RARA fusion gene on a bone marrow specimen every three months for two years, and then every six months for additional three years are needed during the follow-up. PMID:22220261

  15. Organizers.

    ERIC Educational Resources Information Center

    Callison, Daniel

    2000-01-01

    Focuses on "organizers," tools or techniques that provide identification and classification along with possible relationships or connections among ideas, concepts, and issues. Discusses David Ausubel's research and ideas concerning advance organizers; the implications of Ausubel's theory to curriculum and teaching; "webbing," a specific…

  16. Organics.

    ERIC Educational Resources Information Center

    Chian, Edward S. K.; DeWalle, Foppe B.

    1978-01-01

    Presents water analysis literature for 1978. This review is concerned with organics, and it covers: (1) detergents and surfactants; (2) aliphatic and aromatic hydrocarbons; (3) pesticides and chlorinated hydrocarbons; and (4) naturally occurring organics. A list of 208 references is also presented. (HM)

  17. The Florida Survey of Newly Legalized Persons.

    ERIC Educational Resources Information Center

    Schilit, Jeffrey; Nimnicht, Glen

    This study was conducted to gather more definitive information about aliens who were newly legalized under the Immigration Reform and Control Act of 1986. Two groups of eligible legal aliens were interviewed in Florida: those residing in the United States before 1982 (PRE-82s) and special agricultural workers (SAWs). The 1,300 subjects were asked…

  18. Anxiety and the Newly Returned Adult Student

    ERIC Educational Resources Information Center

    Cleary, Michelle Navarre

    2012-01-01

    Based on interviews with students who had recently returned to school, this essay demonstrates the need for, challenges of, and ways to respond to the writing anxiety many adults bring with them back to school. Jessica and Sam were two of twenty-five newly returned adult students whom the author spent over sixty hours interviewing in the fall of…

  19. Rice blast evaluation of newly introduced germplasm

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genetic resistance to the rice blast fungus, Magnaporthe oryzae (anamorph Pyricularia grisea oryzae) was identified in newly introduced rice germplasm through quarantine when tested in artificially inoculated greenhouse and field nursery tests during the 2007 growing season. Of 229 accessions, 31 we...

  20. Magnetospheric substorms - A newly emerging model

    NASA Astrophysics Data System (ADS)

    Akasofu, S.-I.

    1981-10-01

    A surge of progress in magnetospheric substorm studies is expected by the following three recent developments: (1) the finding of the solar wind-magnetosphere energy coupling function epsilon, (2) the determination of the Pedersen current distribution over the entire polar region, and (3) a new understanding of the auroral potential structure. In this paper, the significance of the three developments and the newly emerging model of magnetospheric substorms is described.

  1. Magnetospheric substorms - A newly emerging model

    NASA Technical Reports Server (NTRS)

    Akasofu, S.-I.

    1981-01-01

    A surge of progress in magnetospheric substorm studies is expected by the following three recent developments: (1) the finding of the solar wind-magnetosphere energy coupling function epsilon, (2) the determination of the Pedersen current distribution over the entire polar region, and (3) a new understanding of the auroral potential structure. In this paper, the significance of the three developments and the newly emerging model of magnetospheric substorms is described.

  2. May we practise endotracheal intubation on the newly dead?

    PubMed Central

    Ardagh, M

    1997-01-01

    Endotracheal intubation (ETI) is a valuable procedure which must be learnt and practised, and performing ETI on cadavers is probably the best way to do this, although lesser alternatives do exist. Performing ETI on a cadaver is viewed with a real and reasonable repugnance and if it is done without proper authorisation it might be illegal. Some form of consent is required. Presumed consent would preferably be governed by statute and should only occur if the community is well informed and therefore in a position of being able to decline. Currently neither statute nor adequate informing exists. Endotracheal intubation on the newly dead may be justifiable according to a Guttman scale if the patient has already consented to organ donation and if further research supports the relevance of the Guttman scale to this question. A "mandated choice" with prior individual consent as a matter of public policy is the best of these solutions, however until such a solution is in place we may not practise endotracheal intubation on the newly dead. PMID:9358348

  3. Operational and financial performance of newly established hospices.

    PubMed

    McCue, Michael J; Thompson, Jon M

    2006-01-01

    The objective of the study was to examine the financial and operating performance of newly established, free- standing hospices relative to existing, freestanding hospices. A nonparametric median test was used to compare the median values of operating and financial performance measures between newly established hospices and existing hospices. Operating and financial data were measured for the 2 groups using cost report data from the Centers for Medicare and Medicaid Services. The authors sampled 44 new, freestanding hospices and selected 312 freestanding existing hospices and analyzed their data over 2 years from 2002 to 2003. The study found that 91% of these new hospices were owned by for-profit organizations and were located in the southern region of the United States. New hospices served fewer patients; however, they had a longer length of stay compared to existing hospices. They offered fewer imaging services and radiation therapy services. New hospices generated significantly higher revenue but incurred significantly higher expenses. The results suggest that longer lengths of stay allow these newer hospices to increase revenue and improve overall profitability. PMID:17060288

  4. The Newly Qualified Teacher: A Leader and a Professional? A Norwegian Study

    ERIC Educational Resources Information Center

    Grimsath, Gerd; Nordvik, Grete; Bergsvik, Eli

    2008-01-01

    This article is based on a Norwegian study. The focus is two-fold, including the views of both new teachers and leaders on the issue of leadership and professionalism. First, the focus is on the way newly qualified teachers describe how they function in the school and kindergarten organizations. The discussion explores how new teachers' meetings…

  5. Newly hatched chicks solve the visual binding problem.

    PubMed

    Wood, Justin N

    2014-07-01

    For an organism to perceive coherent and unified objects, its visual system must bind color and shape features into integrated color-shape representations in memory. However, the origins of this ability have not yet been established. To examine whether newborns can build an integrated representation of the first object they see, I raised newly hatched chicks (Gallus gallus) in controlled-rearing chambers that contained a single virtual object. This object rotated continuously, revealing a different color and shape combination on each of its two faces. Chicks were able to build an integrated representation of this object. For example, they reliably distinguished an object defined by a purple circle and yellow triangle from an object defined by a purple triangle and yellow circle. This result shows that newborns can begin binding color and shape features into integrated representations at the onset of their experience with visual objects. PMID:24840718

  6. Newly described or emerging human species of nontuberculous mycobacteria.

    PubMed

    Brown-Elliott, Barbara A; Griffith, David E; Wallace, Richard J

    2002-03-01

    The advent of molecular testing in the laboratory has brought about the recognition of multiple newly characterized mycobacterial species not previously recognizable with most standard techniques. Some of the species are nonpathogenic, but the majority may cause clinical disease. Each is likely to have its own biology, drug susceptibility pattern, and response to drug/surgical therapy. Thus, it is important to try to recognize these new species in the laboratory. A study of the phenotypic and genotypic characteristics of these new species also may help to elucidate the epidemiology and pathogenesis of these organisms. In addition, there are multiple emerging species of nontuberculous mycobacteria including M. ulcerans, M. haemophilum, M. xenopi, and M. malmoense. [table: see text] These species are being recognized increasingly as a cause of human disease and recovered within the laboratory. The clinician must learn about these new pathogens to recognize them clinically and assist the laboratory in their recovery. PMID:11917813

  7. How I treat newly diagnosed chronic myeloid leukemia in 2015.

    PubMed

    Gambacorti-Passerini, Carlo; Piazza, Rocco

    2015-02-01

    The initial treatment for chronic myeloid leukemia in chronic phase (CP-CML) represents a complex process, which includes a prompt and precise diagnosis, the choice among three available tyrosine kinase inhibitors (TKIs), and the initial management of care for these patients, which will protract over a very long period of time. This manuscript summarizes different data on activity, side effects, and supportive measures available for each TKI, the need for particular care in the logistical organization of CML management, the scenario which will be opened by the future availability of generic imatinib. The opinion of the authors is that imatinib remains the first-line treatment for CP-CML; this strategy, accompanied by intensive monitoring and possible dose modification/drug switch after the initial 3-12 months of treatment presently assures a normal life expectancy to the population of newly diagnosed patients with CP-CML. PMID:25370814

  8. Value of a newly sequenced bacterial genome.

    PubMed

    Barbosa, Eudes Gv; Aburjaile, Flavia F; Ramos, Rommel Tj; Carneiro, Adriana R; Le Loir, Yves; Baumbach, Jan; Miyoshi, Anderson; Silva, Artur; Azevedo, Vasco

    2014-05-26

    Next-generation sequencing (NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft (partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the "scientific value" of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. PMID:24921006

  9. Dibenzothiophene desulfurization capability and evolutionary divergence of newly isolated bacteria.

    PubMed

    Akhtar, Nasrin; Ghauri, Muhammad A; Akhtar, Kalsoom

    2016-08-01

    Metabolically microorganisms are diverse, and they are capable of transforming almost every known group of chemical compounds present in coal and oil in various forms. In this milieu, one of the important microbial metabolic processes is the biodesulfurization [cleavage of carbon-sulfur (C-S) bond] of thiophenic compounds, such as dibenzothiophene (DBT), which is the most abundant form of organic sulfur present in fossil fuels. In the current study, ten newly isolated bacterial isolates, designated as species of genera Gordonia, Amycolatopsis, Microbacterium and Mycobacterium, were enriched from different samples in the presence of DBT as a sole source of organic sulfur. The HPLC analysis of the DBT grown cultures indicated the consumption of DBT and accumulation of 2-hydroxybiphenyl (2-HBP). Detection of 2-HBP, a marker metabolite of 4S (sulfoxide-sulfone-sulfinate-sulfate) pathway, suggested that the newly isolated strains harbored metabolic activity for DBT desulfurization through the cleavage of C-S bond. The maximum 2-HBP formation rate was 3.5 µmol/g dry cell weight (DCW)/h. The phylogenetic analysis of the new isolates showed that they had diverse distribution within the phylogenetic tree and formed distinct clusters, suggesting that they might represent strains of already reported species or they were altogether new species. Estimates of evolutionary divergence showed high level of nucleotide divergence between the isolates within the same genus. The new isolates were able to use a range of heterocyclic sulfur compounds, thus making them suitable candidates for a robust biodesulfurization system for fossil fuels. PMID:26973057

  10. The newly-found Rheticus lectures.

    NASA Astrophysics Data System (ADS)

    Kraai, J.

    This article discusses a hitherto unknown set of lectures presumably given by Georg Joachim Rheticus, and taken down by several students in Wittenberg. These lectures offer considerable insight into Rheticus' teaching activities shortly before the publication of De Revolutionibus (1543). The most salient aspects of this newly-found text may be summarized as follows: a) Rheticus was known among the students in Wittenberg as Joachimus Heliopolitanus, i.e. Joachim of the City of the Sun - a clear reference to Rheticus' stay in Frauenburg with Copernicus, b) Rheticus returned from his stay with Copernicus to Wittenberg for a short period of time in 1540 to fulfill his professorial obligations, and c) we have 155 folio pages which document Rheticus' introductory lectures on astronomy.

  11. Understanding the newly observed heavy pentaquark candidates

    NASA Astrophysics Data System (ADS)

    Liu, Xiao-Hai; Wang, Qian; Zhao, Qiang

    2016-06-01

    We find that several thresholds can contribute to the enhancements of the newly observed heavy pentaquark candidates Pc+ (4380) and Pc+ (4450) via the anomalous triangle singularity (ATS) transitions in the specific kinematics of Λb → J / ψK- p. Apart from the observed two peaks we find that another peaks around 4.5 GeV can also be produced by the ATS. We also show that the Σc(*) can be produced at leading order in Λb decay. This process is different from the triangle diagram and its threshold enhancement only appears as CUSP effects if there is no pole structure or the ATS involved. The threshold interaction associated with the presence of the ATS turns out to be a general phenomenon and plays a crucial role in the understanding of candidates for exotic states.

  12. Michael Maier--nine newly discovered letters.

    PubMed

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony. PMID:25241502

  13. Arsenic behavior in newly drilled wells

    USGS Publications Warehouse

    Kim, M.-J.; Nriagu, J.; Haack, S.

    2003-01-01

    In the present paper, inorganic arsenic species and chemical parameters in groundwater were determined to investigate the factors related to the distribution of arsenic species and their dissolution from rock into groundwater. For the study, groundwater and core samples were taken at different depths of two newly drilled wells in Huron and Lapeer Counties, Michigan. Results show that total arsenic concentrations in the core samples varied, ranging from 0.8 to 70.7 mg/kg. Iron concentration in rock was about 1800 times higher than that of arsenic, and there was no correlation between arsenic and iron occurrences in the rock samples. Arsenic concentrations in groundwater ranged from <1 to 171 ??g/l. The arsenic concentration in groundwater depended on the amount of arsenic in aquifer rocks, and as well decreased with increasing depth. Over 90% of arsenic existed in the form of As(III), implying that the groundwater systems were in the reduced condition. The results such as high ferrous ion, low redox potential and low dissolved oxygen supported the observed arsenic species distribution. There was no noticeable difference in the total arsenic concentration and arsenic species ratio between unfiltered and filtered (0.45 ??m) waters, indicating that the particulate form of arsenic was negligible in the groundwater samples. There were correlations between water sampling depth and chemical parameters, and between arsenic concentration and chemical parameters, however, the trends were not always consistent in both wells. ?? 2003 Elsevier Science Ltd. All rights reserved.

  14. 40 CFR 268.38 - Waste specific prohibitions-newly identified organic toxicity characteristic wastes and newly...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CFR 261.32 as EPA Hazardous Waste numbers K141, K142, K143, K144, K145, K147, K148, K149, K150, and... following wastes that are specified in 40 CFR 261.24, Table 1 as EPA Hazardous Waste numbers: D012, D013... covered by the extension. (e) To determine whether a hazardous waste identified in this section...

  15. 40 CFR 268.38 - Waste specific prohibitions-newly identified organic toxicity characteristic wastes and newly...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CFR 261.32 as EPA Hazardous Waste numbers K141, K142, K143, K144, K145, K147, K148, K149, K150, and... following wastes that are specified in 40 CFR 261.24, Table 1 as EPA Hazardous Waste numbers: D012, D013... covered by the extension. (e) To determine whether a hazardous waste identified in this section...

  16. 40 CFR 268.38 - Waste specific prohibitions-newly identified organic toxicity characteristic wastes and newly...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CFR 261.32 as EPA Hazardous Waste numbers K141, K142, K143, K144, K145, K147, K148, K149, K150, and... following wastes that are specified in 40 CFR 261.24, Table 1 as EPA Hazardous Waste numbers: D012, D013... covered by the extension. (e) To determine whether a hazardous waste identified in this section...

  17. 40 CFR 268.38 - Waste specific prohibitions-newly identified organic toxicity characteristic wastes and newly...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CFR 261.32 as EPA Hazardous Waste numbers K141, K142, K143, K144, K145, K147, K148, K149, K150, and... following wastes that are specified in 40 CFR 261.24, Table 1 as EPA Hazardous Waste numbers: D012, D013... production wastes. 268.38 Section 268.38 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...

  18. Dynamics of newly established elk populations

    USGS Publications Warehouse

    Sargeant, G.A.; Oehler, M.W., Sr.

    2007-01-01

    The dynamics of newly established elk (Cervus elaphus) populations can provide insights about maximum sustainable rates of reproduction, survival, and increase. However, data used to estimate rates of increase typically have been limited to counts and rarely have included complementary estimates of vital rates. Complexities of population dynamics cannot be understood without considering population processes as well as population states. We estimated pregnancy rates, survival rates, age ratios, and sex ratios for reintroduced elk at Theodore Roosevelt National Park, North Dakota, USA; combined vital rates in a population projection model; and compared model projections with observed elk numbers and population ratios. Pregnancy rates in January (early in the second trimester of pregnancy) averaged 54.1% (SE = 5.4%) for subadults and 91.0% (SE = 1.7%) for adults, and 91.6% of pregnancies resulted in recruitment at 8 months. Annual survival rates of adult females averaged 0.96 (95% CI = 0.94-0.98) with hunting included and 0.99 (95% CI = 0.97-0.99) with hunting excluded from calculations. Our fitted model explained 99.8% of past variation in population estimates and represents a useful new tool for short-term management planning. Although we found no evidence of temporal variation in vital rates, variation in population composition caused substantial variation in projected rates of increase (??=1.20-1.36). Restoring documented hunter harvests and removals of elk by the National Park Service led to a potential rate of ?? = 1.26. Greater rates of increase substantiated elsewhere were within the expected range of chance variation, given our model and estimates of vital rates. Rates of increase realized by small elk populations are too variable to support inferences about habitat quality or density dependence.

  19. Newly Identified Pathogens Associated with Periodontitis

    PubMed Central

    Pérez-Chaparro, P.J.; Gonçalves, C.; Figueiredo, L.C.; Faveri, M.; Lobão, E.; Tamashiro, N.; Duarte, P.; Feres, M.

    2014-01-01

    There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of independent-culture diagnostic methods introduced about a decade ago have pointed to the existence of new periodontal pathogens. However, the data of these studies have not been evaluated together, which may generate some misunderstanding on the actual role of these microorganisms in the etiology of periodontitis. The aim of this systematic review was to determine the current weight of evidence for newly identified periodontal pathogens based on the results of “association” studies. This review was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE, and Cochrane databases were searched up to September 2013 for studies (1) comparing microbial data of subgingival plaque samples collected from subjects with periodontitis and periodontal health and (2) evaluating at least 1 microorganism other than the already-known periodontal pathogens. From 1,450 papers identified, 41 studies were eligible. The data were extracted and registered in predefined piloted forms. The results suggested that there is moderate evidence in the literature to support the association of 17 species or phylotypes from the phyla Bacteroidetes, Candidatus Saccharibacteria, Firmicutes, Proteobacteria, Spirochaetes, and Synergistetes. The phylum Candidatus Saccharibacteria and the Archaea domain also seem to have an association with disease. These data point out the importance of previously unidentified species in the etiology of periodontitis and might guide future investigations on the actual role of these suspected new pathogens in the onset and progression of this infection. PMID:25074492

  20. Vitamin C nutriture in newly diagnosed diabetes.

    PubMed

    Shim, Jae Eun; Paik, Hee Young; Shin, Chan Soo; Park, Kyong Soo; Lee, Hong Kyu

    2010-01-01

    This study was performed to investigate the relationship between serum L-ascorbic acid, vitamin C intake, and diabetes in a nested case-control study. A cross-sectional survey of diet and health was conducted in 2,048 adults with an age of 30 y or older in Yonchon County, Korea. An oral glucose tolerance test was administered to all participants. One hundred cases of newly diagnosed diabetes were identified. Two healthy controls for each case matched with age, gender, drinking status, and smoking status were selected among the survey participants. L-Ascorbic acid levels were analyzed in fasting serum samples and one 24-h dietary recall was performed. Dietary vitamin C intake of persons with diabetes was 50.1±47.6 mg/d and that of controls was 55.1±41.1 mg/d. People with diabetes (22.3±16.8 µmol/L) have lower serum ascorbic acid levels than their controls (26.3±17.0 µmol/L) and the difference was significant by paired t-test (p<0.01). The association between diabetes and serum ascorbic acid level was still significant in non-smokers (24.2±17.8 µmol/L for the diabetes group and 29.5±16.7 µmol/L for the control group, p<0.01) but not in smokers (19.4±15.7 µmol/L for the diabetes group and 21.2±16.0 µmol/L for the control group). Our results suggest that diabetes and smoking interactively affect serum ascorbic acid levels. Since this population had poor nutritional status of vitamin C, further investigation of association between serum ascorbic acid level and diabetes and smoking by the level of vitamin C consumption is warranted. PMID:20924142

  1. Newly Identified Rydberg Emission Lines in Novae

    NASA Astrophysics Data System (ADS)

    Lynch, David K.; Rudy, R. J.; Bernstein, L. S.

    2008-09-01

    Newly Identified Rydberg Emission Lines in Novae David K. Lynch, Richard. J. Rudy (The Aerospace Corporation) & Lawrence S. Bernstein (Spectral Sciences, Inc.) Novae spectra in the near infrared frequently show a set of six emission lines that have not been positively identified (Williams, Longmore, & Geballe 1996, MNRAS, 279, 804; Lynch et al. 2001, AJ, 122, 2013; Rudy et al. 2002 ApJ, 573, 794; Lynch et al. 2004 Astron. J. 127, 1089-1097). These lines are at 0.8926, 1.1114, 1.1901, 1.5545, 2.0996 and 2.425 µm ± 0.005 µm. Krautter et al. (1984 A&A 137, 304) suggested that three of the lines were due to rydberg (hydrogenic) transitions in an unspecified atomic species that was in the 4th or 5th ionization stage (core charge = 4 & 5). We believe that Krautter et al.'s explanation is correct based on 4 additional lines that we have identified in the visible and near infrared spectrum of V723 Cassiopeiae. The observed Rydberg lines appear to originate from high angular momentum states with negligible quantum defects. The species cannot be determined with any certainty because in rydberg states, the outer electron sees a nucleus shielded by the inner electrons and together the inner atom appears to have a charge of +1, like hydrogen. As a result, the atom looks hydrogenic and species such as CV, NV, OV, MgV, SiV, etc. have their rydberg transitions at very similar wavelengths. All the lines represent permitted transitions, most likely formed by recombination. Atoms with core charges 4, 5 & 6 are rarely seen in the astrophysical environment because an extremely hot radiation field is necessary to ionize them. Thermonuclear runaways on the surface of a white dwarf can reach millions of degrees K, and thus there are enough X-ray photons available to achieve the necessary high ionization levels.

  2. Disclosure obligations of the newly public healthcare company: practical strategies for the company and its counsel.

    PubMed

    Horton, W W; McFadden, F H

    1999-01-01

    Founders of healthcare companies, like entrepreneurs in general, dream of the opportunity to take their companies public. The benefits flowing from access to the public markets, however, carry with them additional responsibilities that are enforceable both by the regulatory authorities and the well-organized plaintiffs' securities bar. The authors of this Article provide the newly public company and its counsel extensive guidance for the navigation of this regulatory maze. PMID:10569844

  3. Legionnaires' disease organism, legionella (image)

    MedlinePlus

    ... an outbreak of fatal pneumonia at a Legionnaires convention. The newly described organism which caused the disease was named Legionella pneumophila, shown in this picture. (Image courtesy of the Centers for Disease Control and Prevention.)

  4. [Newly developed nomenclature (Neuroscience-based Nomenclature)].

    PubMed

    Uchida, Hiroyuki; Yamawaki, Shigeto

    2016-06-01

    The current nomenclature is based on clinical indications; for example, drugs used for mania and psychosis are classified as "mood stabilizers" and "antipsychotic drugs", respectively. This discrepancy between their names and indications often confuses patients and their caregivers and sometimes leads to a misunderstanding of the effects of prescribed medications. In addition, up-to-date scientific knowledge on these drugs has not been reflected in the current nomenclature. To overcome these limitations of the current nomenclature, following an initiative of the European Congress of Neuropsychopharmacology (ECNP), a taskforce for psychotropic nomenclature was established with representatives from 5 international organizations, including the Asian College of Neuropsychopharmacology (AsCNP). The mission of this taskforce is to provide a pharmacologically-driven (rather than indication-based) nomenclature, which is now referred to as Neuroscience-based Nomenclature (NbN). The NbN project has just started. Since it always takes time to change the culture, we understand the transition will likely involve some expected and unexpected responses from the field. However, we believe that such responses and feedback will surely improve the quality of the NbN, which in turn will be beneficial for clinicians, researchers, and patients as well as their caregivers. PMID:27506083

  5. Newly Released Inmates Account for 1 in 10 Fatal ODs

    MedlinePlus

    ... fullstory_159858.html Newly Released Inmates Account for 1 in 10 Fatal ODs Many may not realize ... the general population," Persaud added. Not only did one in 10 overdose deaths involve a recently released ...

  6. Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins

    PubMed Central

    Gimber, Niclas; Tadeus, Georgi; Maritzen, Tanja; Schmoranzer, Jan; Haucke, Volker

    2015-01-01

    Neurotransmission relies on the calcium-triggered exocytic fusion of non-peptide neurotransmitter-containing small synaptic vesicles (SVs) with the presynaptic membrane at active zones (AZs) followed by compensatory endocytic retrieval of SV membranes. Here, we study the diffusional fate of newly exocytosed SV proteins in hippocampal neurons by high-resolution time-lapse imaging. Newly exocytosed SV proteins rapidly disperse within the first seconds post fusion until confined within the presynaptic bouton. Rapid diffusional spread and confinement is followed by slow reclustering of SV proteins at the periactive endocytic zone. Confinement within the presynaptic bouton is mediated in part by SV protein association with the clathrin-based endocytic machinery to limit diffusional spread of newly exocytosed SV proteins. These data suggest that diffusion, and axonal escape of newly exocytosed vesicle proteins, are counteracted by the clathrin-based endocytic machinery together with a presynaptic diffusion barrier. PMID:26399746

  7. Higher Education, Democracy, and Development: Implications for Newly Industrialized Countries.

    ERIC Educational Resources Information Center

    Altbach, Philip G.

    1992-01-01

    Discusses the university's role in emerging economies of the Pacific Rim's Newly Industrialized Countries, noting that universities are central to educating people for technologically oriented societies, providing a voice to emerging democracies. (SM)

  8. Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins

    NASA Astrophysics Data System (ADS)

    Gimber, Niclas; Tadeus, Georgi; Maritzen, Tanja; Schmoranzer, Jan; Haucke, Volker

    2015-09-01

    Neurotransmission relies on the calcium-triggered exocytic fusion of non-peptide neurotransmitter-containing small synaptic vesicles (SVs) with the presynaptic membrane at active zones (AZs) followed by compensatory endocytic retrieval of SV membranes. Here, we study the diffusional fate of newly exocytosed SV proteins in hippocampal neurons by high-resolution time-lapse imaging. Newly exocytosed SV proteins rapidly disperse within the first seconds post fusion until confined within the presynaptic bouton. Rapid diffusional spread and confinement is followed by slow reclustering of SV proteins at the periactive endocytic zone. Confinement within the presynaptic bouton is mediated in part by SV protein association with the clathrin-based endocytic machinery to limit diffusional spread of newly exocytosed SV proteins. These data suggest that diffusion, and axonal escape of newly exocytosed vesicle proteins, are counteracted by the clathrin-based endocytic machinery together with a presynaptic diffusion barrier.

  9. Chemoradiotherapy of Newly Diagnosed Glioblastoma With Intensified Temozolomide

    SciTech Connect

    Weiler, Markus; Hartmann, Christian; Wiewrodt, Dorothee; Herrlinger, Ulrich

    2010-07-01

    Purpose: To evaluate the toxicity and efficacy of chemoradiotherapy with temozolomide (TMZ) administered in an intensified 1-week on/1-week off schedule plus indomethacin in patients with newly diagnosed glioblastoma. Patients and Methods: A total of 41 adult patients (median Karnofsky performance status, 90%; median age, 56 years) were treated with preirradiation TMZ at 150 mg/m{sup 2} (1 week on/1 week off), involved-field radiotherapy combined with concomitant low-dose TMZ (50 mg/m{sup 2}), maintenance TMZ starting at 150 mg/m{sup 2} using a 1-week on/1-week off schedule, plus maintenance indomethacin (25 mg twice daily). Results: The median follow-up interval was 21.7 months. Grade 4 hematologic toxicity was observed in 15 patients (36.6%). Treatment-related nonhematologic Grade 4-5 toxicity was reported for 2 patients (4.9%). The median progression-free survival was 7.6 months (95% confidence interval, 6.2-10.4). The 1-year survival rate was 73.2% (95% confidence interval, 56.8-84.2%). The presence of O{sup 6}-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation in the tumor tissue was associated with significantly superior progression-free survival. Conclusion: The dose-dense regimen of TMZ administered in a 1-week on/1-week off schedule resulted in acceptable nonhematologic toxicity. Compared with data from the European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada trial 26981-22981/CE.3, patients with an unmethylated MGMT gene promoter appeared not to benefit from intensifying the TMZ schedule regarding the median progression-free survival and overall survival. In contrast, data are promising for patients with a methylated MGMT promoter.

  10. In-vehicle VOCs composition of unconditioned, newly produced cars.

    PubMed

    Brodzik, Krzysztof; Faber, Joanna; Łomankiewicz, Damian; Gołda-Kopek, Anna

    2014-05-01

    The in-vehicle volatile organic compounds (VOCs) concentrations gains the attention of both car producers and users. In the present study, an attempt was made to determine if analysis of air samples collected from an unconditioned car cabin can be used as a quality control measure. The VOCs composition of in-vehicle air was analyzed by means of active sampling on Carbograph 1TD and Tenax TA sorbents, followed by thermal desorption and simultaneous analysis on flame ionization and mass detector (TD-GC/FID-MS). Nine newly produced cars of the same brand and model were chosen for this study. Within these, four of the vehicles were equipped with identical interior materials and five others differed in terms of upholstery and the presence of a sunroof; one car was convertible. The sampling event took place outside of the car assembly plant and the cars tested left the assembly line no later than 24 hr before the sampling took place. More than 250 compounds were present in the samples collected; the identification of more than 160 was confirmed by comparative mass spectra analysis and 80 were confirmed by both comparison with single/multiple compounds standards and mass spectra analysis. In general, aliphatic hydrocarbons represented more than 60% of the total VOCs (TVOC) determined. Depending on the vehicle, the concentration of aromatic hydrocarbons varied from 12% to 27% of total VOCs. The very short period between car production and sampling of the in-vehicle air permits the assumption that the entire TVOC originates from off-gassing of interior materials. The results of this study expand the knowledge of in-vehicle pollution by presenting information about car cabin air quality immediately after car production. PMID:25079635

  11. Direct visualization of identified and newly synthesized proteins in situ

    PubMed Central

    Dieck, Susanne tom; Kochen, Lisa; Hanus, Cyril; Bartnik, Ina; Nassim-Assir, Belquis; Merk, Katrin; Mosler, Thorsten; Garg, Sakshi; Bunse, Stefanie; Tirrell, David A.; Schuman, Erin M.

    2015-01-01

    Protein synthesis is a dynamic process to tune the cellular proteome to internal and external demands. Metabolic labeling approaches identify the general proteomic response but missing is a tool to visualize within cells specific newly synthesized proteins. Here we describe a technique that couples non-canonical amino acid tagging or puromycylation with the proximity-ligation assay to visualize identified newly synthesized proteins and monitor their origin, redistribution and turnover in situ. PMID:25775042

  12. Advances in the treatment of newly diagnosed glioblastoma.

    PubMed

    Theeler, Brett J; Gilbert, Mark R

    2015-01-01

    Glioblastoma is a refractory malignancy with limited treatment options at tumor recurrence. Only a small proportion of patients survive 2 years or longer with the current standard of care. Gene expression profiling can segregate newly diagnosed patients into groups with different prognoses, and these biomarkers are being incorporated into a new generation of personalized clinical trials. Using the experience from recently completed large scale, multi-faceted, randomized glioblastoma clinical trials, a new clinical trial paradigm is being established to move promising therapies forward into the newly diagnosed treatment setting. Upcoming trials using the immune check-point inhibitors are an example of this changing paradigm and these and other immunotherapies have potential as promising new treatment modalities for newly diagnosed GB patients. PMID:26646075

  13. [Principles of nutrition in patients with newly appointed stoma].

    PubMed

    Pachocka, Lucyna Małgorzata; Urbanik, Anna

    2016-01-01

    The treatment of intestinal stoma is often a difficult experience for patients and results in numerous problems in the physical, psychological and social aspects. Therefore, post-operative care of the patient with the newly appointed stoma should be taken by therapeutic team consisting of doctors, nurses, physiotherapists, dieticians, psychologists and social workers. Appropriate nutritional education of patients aims to improve their quality of life and to prevent from unpleasant ailments formed after the operation. The specific type of stoma may decide about certain dietary recommendations. The presented work provides a practical dietary recommendations for patients with newly appointed stoma. PMID:27162293

  14. Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines.

    PubMed

    Filho, Edismauro Garcia Freitas; da Silva, Elaine Zayas Marcelino; Zanotto, Camila Ziliotto; Oliver, Constance; Jamur, Maria Célia

    2016-01-01

    Mast cells are immunoregulatory cells that participate in inflammatory processes. Cross-linking mast cell specific GD1b derived gangliosides by mAbAA4 results in partial activation of mast cells without the release of preformed mediators. The present study examines the release of newly formed and newly synthesized mediators following ganglioside cross-linking. Cross-linking the gangliosides with mAbAA4 released the newly formed lipid mediators, prostaglandins D2 and E2, without release of leukotrienes B4 and C4. The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2. Translocation of 5-lipoxygenase from the cytosol to the nucleus was not induced by ganglioside cross-linking. Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-α. The effect of cross-linking the gangliosides on the MAP kinase pathway was then investigated. Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. Therefore, cross-linking the mast cell specific GD1b derived gangliosides results in the activation of signaling pathways that culminate with the release of newly formed and newly synthesized mediators. PMID:27578923

  15. Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines

    PubMed Central

    Zanotto, Camila Ziliotto

    2016-01-01

    Mast cells are immunoregulatory cells that participate in inflammatory processes. Cross-linking mast cell specific GD1b derived gangliosides by mAbAA4 results in partial activation of mast cells without the release of preformed mediators. The present study examines the release of newly formed and newly synthesized mediators following ganglioside cross-linking. Cross-linking the gangliosides with mAbAA4 released the newly formed lipid mediators, prostaglandins D2 and E2, without release of leukotrienes B4 and C4. The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2. Translocation of 5-lipoxygenase from the cytosol to the nucleus was not induced by ganglioside cross-linking. Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-α. The effect of cross-linking the gangliosides on the MAP kinase pathway was then investigated. Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. Therefore, cross-linking the mast cell specific GD1b derived gangliosides results in the activation of signaling pathways that culminate with the release of newly formed and newly synthesized mediators. PMID:27578923

  16. 26. View of fully flooded drydock with caisson opened. Newly ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. View of fully flooded drydock with caisson opened. Newly arrived submarine is being placed in position. Berthed submarine on right is same as that seen in photo WA-116-25. Camera is pointed S from bulkhead. - Puget Sound Naval Shipyard, Drydock No. 3, Farragut Avenue, Bremerton, Kitsap County, WA

  17. Field Performance of a Newly Developed Upflow Filtration Device

    EPA Science Inventory

    The objective of this research is to examine the removal capacities of a newly developed Upflow filtration device for treatment of stormwater. The device was developed by engineers at the University of Alabama through a Small Business Innovative Research (SBIR) grant from the U....

  18. Creating a Positive School Culture in Newly Opened Schools

    ERIC Educational Resources Information Center

    Holmes, Michael Todd

    2009-01-01

    The purpose of this study was to determine the most effective practices by school administrators when creating school culture in newly opened schools. Using semi-structured interviews, four principals who opened a new school were interviewed individually and in a focus group. The constant comparative method was used to analyze the data. Two themes…

  19. Death Concerns among Individuals Newly Diagnosed with Lung Cancer

    ERIC Educational Resources Information Center

    Lehto, Rebecca; Therrien, Barbara

    2010-01-01

    Confronting the reality of death is an important challenge for individuals facing life-threatening illness such as lung cancer, the leading cause of cancer death. Few studies, however, document the nature of death-related concerns in individuals newly diagnosed with lung cancer. The aims of this exploratory study were to examine unsolicited…

  20. Who Is Doing Well? A Typology of Newly Homeless Adolescents

    ERIC Educational Resources Information Center

    Milburn, Norweeta; Liang, Li-Jung; Lee, Sung-Jae; Rotheram-Borus, Mary Jane; Rosenthal, Doreen; Mallett, Shelley; Lightfoot, Marguerita; Lester, Patricia

    2009-01-01

    There is growing evidence to support developing new typologies for homeless adolescents. Current typologies focus on the risks associated with being homeless, with less consideration of the positive attributes of homeless adolescents. The authors examined both risk and protective factors in a sample of newly homeless adolescents. Using cluster…

  1. Recontextualising Professional Knowledge--Newly Qualified Nurses and Physicians

    ERIC Educational Resources Information Center

    Smeby, Jens-Christian; Vagan, Andre

    2008-01-01

    This article examines the discrepancy between newly qualified nurses' and physicians' assessment of acquired knowledge in education and their assessment of the knowledge demands in occupational practice. Knowledge learned in educational institutions is traditionally conceived as general and decontextualised with great potential for transmission…

  2. Dilemmas of a Newly Recruited Academic Qualified Professor: A Case

    ERIC Educational Resources Information Center

    Agrawal, Anand

    2015-01-01

    This case describes the situation of a newly recruited academic professor who volunteered to teach a course on Research Methods to first-term MBA students in a practitioner-oriented case method Business School. Research Methods is a unique course due to its relevance not only in business but also across all graduate programs. Instructional and…

  3. Enhancing the Employability of Newly Qualified Nurses: A Pilot Study

    ERIC Educational Resources Information Center

    Dray, Beattie; Burke, Linda; Hurst, Heather M.; Ferguson, Anne; Marks-Maran, Diane

    2011-01-01

    Vocationally based higher education programmes are meant to prepare people for employment in their chosen fields of study. In nursing, historically, employment after qualifying has been almost assured, with sufficient vacancies available for newly qualified nurses. Recently, however, for a number of reasons, primarily related to economic…

  4. Triadic Interaction among Newly Acquainted 2-Year-Olds

    ERIC Educational Resources Information Center

    Ishikawa, Fumiko; Hay, Dale F.

    2006-01-01

    Are children as young as 2 years old able to interact in groups of three? The study applied the family triad model first introduced by Parke, Power, and Gottman (1979) to the case of peer interaction. In Experiment 1, the model was refined for use in studies of peer interaction and applied to an existing dataset of 16 triads of newly acquainted…

  5. 30 CFR 46.6 - Newly hired experienced miner training.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Newly hired experienced miner training. 46.6 Section 46.6 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND RETRAINING OF MINERS ENGAGED IN SHELL DREDGING OR EMPLOYED AT SAND, GRAVEL,...

  6. 30 CFR 46.6 - Newly hired experienced miner training.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Newly hired experienced miner training. 46.6 Section 46.6 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND RETRAINING OF MINERS ENGAGED IN SHELL DREDGING OR EMPLOYED AT SAND, GRAVEL,...

  7. 30 CFR 46.6 - Newly hired experienced miner training.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Newly hired experienced miner training. 46.6 Section 46.6 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND RETRAINING OF MINERS ENGAGED IN SHELL DREDGING OR EMPLOYED AT SAND, GRAVEL,...

  8. 30 CFR 46.6 - Newly hired experienced miner training.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Newly hired experienced miner training. 46.6 Section 46.6 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND RETRAINING OF MINERS ENGAGED IN SHELL DREDGING OR EMPLOYED AT SAND, GRAVEL,...

  9. 30 CFR 46.6 - Newly hired experienced miner training.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Newly hired experienced miner training. 46.6 Section 46.6 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING TRAINING AND RETRAINING OF MINERS ENGAGED IN SHELL DREDGING OR EMPLOYED AT SAND, GRAVEL,...

  10. Newly Generated Liquid Waste Processing Alternatives Study, Volume 1

    SciTech Connect

    Landman, William Henry; Bates, Steven Odum; Bonnema, Bruce Edward; Palmer, Stanley Leland; Podgorney, Anna Kristine; Walsh, Stephanie

    2002-09-01

    This report identifies and evaluates three options for treating newly generated liquid waste at the Idaho Nuclear Technology and Engineering Center of the Idaho National Engineering and Environmental Laboratory. The three options are: (a) treat the waste using processing facilities designed for treating sodium-bearing waste, (b) treat the waste using subcontractor-supplied mobile systems, or (c) treat the waste using a special facility designed and constructed for that purpose. In studying these options, engineers concluded that the best approach is to store the newly generated liquid waste until a sodium-bearing waste treatment facility is available and then to co-process the stored inventory of the newly generated waste with the sodium-bearing waste. After the sodium-bearing waste facility completes its mission, two paths are available. The newly generated liquid waste could be treated using the subcontractor-supplied system or the sodium-bearing waste facility or a portion of it. The final decision depends on the design of the sodium-bearing waste treatment facility, which will be completed in coming years.

  11. Nuclear reaction effects in use of newly recommended quality factor

    NASA Technical Reports Server (NTRS)

    Shinn, Judy L.; Wilson, John W.

    1991-01-01

    The biological risk for energetic ion exposure cannot be reliably estimated exclusive of the target nuclear reaction products produced within the local tissue. A theoretical basis is derived for evaluating target fragment contributions that are evaluated for the newly proposed quality factor.

  12. The Newly Qualified Teacher in the Working Community

    ERIC Educational Resources Information Center

    Nyman, Tarja

    2014-01-01

    Focusing on the working community, this article concentrates on the newly qualified foreign language teachers' (NQT) experiences and on factors that promoted or prevented the development of professional expertise at the outset of their working life. It draws on a qualitative longitudinal study conducted at the University of Jyväskylä,…

  13. Resume Writing in Russia and the Newly Independent States

    ERIC Educational Resources Information Center

    Bowen, Betsy; Sapp, David Alan; Sargsyan, Nelly

    2006-01-01

    This article examines the teaching of resume writing at one university in Russia and several institutions in the Newly Independent States (NIS). The authors explore challenges including variable cultural norms for written versus oral communication, severe financial and material hardship in the educational sector, cultural discomfort with the norms…

  14. Why does A&E attract newly qualified registered nurses?

    PubMed

    Cronin, Gerard; Cronin, Camille

    2006-04-01

    Workforce planning is a particular buzzword that nurse managers must grapple with and now must understand. They must develop strategies to ensure the life and growth of a department while incorporating numerous government targets to ensure the service reaches quality, achieves and meets predetermined goals. To do all this that manager needs a workforce. The recruitment of nursing staff to a specialist area such as Accident & Emergency (A&E) requires a level of creativity and sustained effort. Newly qualified registered nurse working in A&E have, in the past, been considered to be an unusual group of staff to apply to work in A&E. However, many health service managers receive applications from staff in this category and are often encouraged to recruit newly qualified registered nurse's rather than pay for agency workers. Using a qualitative approach this paper explores the key reasons why newly qualified registered nurses choose to work in an Accident & Emergency environment. Data was collected from a sample of 25 newly qualified registered nurses and analysed thematically. Five themes are presented: challenge, teamwork, diversity, support, and learning. These themes have implications for Accident and Emergency units and human resource and workforce planning departments. PMID:16464593

  15. Oral Definitions of Newly Learned Words: An Error Analysis

    ERIC Educational Resources Information Center

    Steele, Sara C.

    2012-01-01

    This study examined and compared patterns of errors in the oral definitions of newly learned words. Fifteen 9- to 11-year-old children with language learning disability (LLD) and 15 typically developing age-matched peers inferred the meanings of 20 nonsense words from four novel reading passages. After reading, children provided oral definitions…

  16. Self-Regulation in Newly Arrived International Adoptees

    ERIC Educational Resources Information Center

    Tirella, Linda Grey; Miller, Laurie C.

    2011-01-01

    Many newly arrived international adoptees (IA) have difficulties with eating, sleeping, and self-soothing/self-stimulating (SS) behaviors. However, to date the prevalence of these problems and associated risk factors have not been clearly identified. Therefore, we proposed to evaluate 387 IA for the presence of these self-regulation and behavioral…

  17. Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The role of increased gluconeogenesis as an important contributor to fasting hyperglycaemia at diabetes onset is not known. We evaluated the contribution of gluconeogenesis and glycogenolysis to fasting hyperglycaemia in newly diagnosed youths with type 2 diabetes following an overnight fast. Basal ...

  18. Insights into the growth of newly formed particles in a subtropical urban environment

    NASA Astrophysics Data System (ADS)

    Salimi, F.; Crilley, L. R.; Stevanovic, S.; Ristovski, Z.; Mazaheri, M.; He, C.; Johnson, G.; Ayoko, G.; Morawska, L.

    2015-12-01

    The role of different chemical compounds, particularly organics, involved in the new particle formation (NPF) and its consequent growth are not fully understood. Therefore, this study was conducted to investigate the chemical composition of aerosol particles during NPF events in an urban subtropical environment. Aerosol chemical composition was measured along with particle number size distribution (PNSD) and several other air quality parameters at five sites across an urban subtropical environment. An Aerodyne compact Time-of-Flight Aerosol Mass Spectrometer (c-ToF-AMS) and a TSI Scanning Mobility Particle Sizer (SMPS) measured aerosol chemical composition (particles above 50 nm in vacuum aerodynamic diameter) and PNSD (particles within 9-414 nm in mobility diameter), respectively. Five NPF events, with growth rates in the range 3.3-4.6 nm, were detected at two of the sites. The NPF events happened on relatively warmer days with lower condensation sink (CS). Temporal percent fractions of organics increased after the particles grew enough to have a significant contribution to particle volume, while the mass fraction of ammonium and sulfate decreased. This uncovered the important role of organics in the growth of newly formed particles. Three organic markers, factors f43, f44 and f57, were calculated and the f44 vs. f43 trends were compared between nucleation and non-nucleation days. K-means cluster analysis was performed on f44 vs. f43 data and it was found that they follow different patterns on nucleation days compared to non-nucleation days, whereby f43 decreased for vehicle-emission-generated particles, while both f44 and f43 decreased for NPF-generated particles. It was found for the first time that vehicle-generated and newly formed particles cluster in different locations on f44 vs. f43 plot, and this finding can be potentially used as a tool for source apportionment of measured particles.

  19. Flagellation of Pseudomonas aeruginosa in newly divided cells

    NASA Astrophysics Data System (ADS)

    Zhao, Kun; Lee, Calvin; Anda, Jaime; Wong, Gerard

    2015-03-01

    For monotrichous bacteria, Pseudomonas aeruginosa, after cell division, one daughter cell inherits the old flagellum from its mother cell, and the other grows a new flagellum during or after cell division. It had been shown that the new flagellum grows at the distal pole of the dividing cell when the two daughter cells haven't completely separated. However, for those daughter cells who grow new flagella after division, it still remains unknown at which pole the new flagellum will grow. Here, by combining our newly developed bacteria family tree tracking techniques with genetic manipulation method, we showed that for the daughter cell who did not inherit the old flagellum, a new flagellum has about 90% chances to grow at the newly formed pole. We proposed a model for flagellation of P. aeruginosa.

  20. Visualisation of newly synthesised collagen in vitro and in vivo

    PubMed Central

    Oostendorp, Corien; Uijtdewilligen, Peter J.E.; Versteeg, Elly M.; Hafmans, Theo G.; van den Bogaard, Ellen H.; de Jonge, Paul K.J.D.; Pirayesh, Ali; Von den Hoff, Johannes W.; Reichmann, Ernst; Daamen, Willeke F.; van Kuppevelt, Toin H.

    2016-01-01

    Identifying collagen produced de novo by cells in a background of purified collagenous biomaterials poses a major problem in for example the evaluation of tissue-engineered constructs and cell biological studies to tumor dissemination. We have developed a universal strategy to detect and localize newly deposited collagen based on its inherent association with dermatan sulfate. The method is applicable irrespective of host species and collagen source. PMID:26738984

  1. The Circulation of Newly Formed Deep Water in the Atlantic

    NASA Astrophysics Data System (ADS)

    Rhein, M.; Kieke, D.; Steinfeldt, R.

    2012-04-01

    The circulation of newly formed deep water masses (Labrador Sea Water, LSW, and Denmark Strait Overflow Water, DSOW) is examined by discussing the distribution of two parameters (age τ and fraction F of young water) calculated from the chlorofluorocarbon data measured between 1980 and 2005 in the Atlantic. Compared to previous studies, a much larger data set was used with an improved gridding procedure, allowing to resolve the distributions in more detail.

  2. 35. LOW OBLIQUE AERIAL VIEW LOOKING EAST OVER THE NEWLY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. LOW OBLIQUE AERIAL VIEW LOOKING EAST OVER THE NEWLY CONSTRUCTED NAVAL SUPPLY CENTER. NORTH TRAINING WALL AND FEDERAL CHANNEL ARE AT FAR RIGHT. Dated 23 April 1942. U.S. Navy photograph from the Fleet Industrial Supply Center archive (FISCO; Naval Supply Center, Oakland). Original print on file at the Port of Oakland, California. - Oakland Harbor Training Walls, Mouth of Federal Channel to Inner Harbor, Oakland, Alameda County, CA

  3. Prevalence of and risk factors for pulmonary tuberculosis among newly diagnosed HIV-1 infected Nigerian children

    PubMed Central

    Ebonyi, Augustine O.; Oguche, Stephen; Ejeliogu, Emeka U.; Agbaji, Oche O.; Shehu, Nathan Y.; Abah, Isaac O.; Sagay, Atiene S.; Ugoagwu, Placid O.; Okonkwo, Prosper I.; Idoko, John A.; Kanki, Phyllis J.

    2016-01-01

    Introduction Studies on the prevalence of and risk factors for tuberculosis (TB) among newly diagnosed human immunodeficiency virus (HIV)-infected children in sub-Saharan Africa are scarce and in Nigeria there is paucity of reported data. We determined the prevalence of and risk factors for pulmonary TB (PTB) in newly diagnosed (treatment-naïve) HIV-1 infected children at the pediatric HIV clinic of the Jos University Teaching Hospital (JUTH) in Nigeria. Methods We performed a retrospective analysis of 876 children, aged 2 months – 13 years, diagnosed with HIV-1 infection between July 2005 and December 2012, of which 286 were diagnosed with PTB at presentation after TB screening. The study site was the AIDS Prevention Initiative in Nigeria (APIN)-supported Pediatric HIV clinic at JUTH, Jos. A multivariate forward logistic regression modelling was used to identify risk factors for PTB-HIV co-infection. Results The prevalence of PTB-HIV co-infection was 32% (286/876). Severe immunosuppression (SI) and World Health Organization (WHO) HIV clinical stage 3/4 were identified as independent risk factors for PTB-HIV co-infection in HIV infected children. The odds of PTB-HIV co-infection was increased two-fold in HIV-infected children with WHO clinical stage 3/4 compared to those with stage 1/2 (adjusted odds ratio (AOR) 1.76 [1.31-2.37], p<0.001) and 1.5-fold in children with SI compared to those without SI (AOR 1.52 [1.12-2.06], p=0.007). Conclusion In our setting, the burden of PTB was high among newly diagnosed HIV-infected children, and late WHO HIV clinical stage and severe immunosuppression were associated with PTB-HIV co-infection. Therefore there is a clear need to improve strategies for early diagnosis of both HIV and PTB to optimize clinical outcomes. PMID:27019829

  4. Chromosome 1 abnormalities in elderly patients with newly diagnosed multiple myeloma treated with novel therapies.

    PubMed

    Caltagirone, Simona; Ruggeri, Marina; Aschero, Simona; Gilestro, Milena; Oddolo, Daniela; Gay, Francesca; Bringhen, Sara; Musolino, Caterina; Baldini, Luca; Musto, Pellegrino; Petrucci, Maria T; Gaidano, Gianluca; Passera, Roberto; Bruno, Benedetto; Palumbo, Antonio; Boccadoro, Mario; Omedè, Paola

    2014-10-01

    Multiple myeloma is a plasma cell disorder characterized by malignant plasma cell infiltration in the bone marrow, serum and/or urine monoclonal protein and organ damage. The aim of this study was to investigate the impact of chromosome 1 abnormalities in a group of elderly patients (>65 years) with newly diagnosed multiple myeloma enrolled in the GIMEMA-MM-03-05 trial and treated with bortezomib, melphalan and prednisone or bortezomib, melphalan, prednisone and thalidomide followed by bortezomib and thalidomide maintenance. We also evaluated the link between chromosome 1 abnormalities and other clinical, genetic and immunophenotypic features by a multivariate logistic regression model. Interphase fluorescence in situ hybridization on immunomagnetically purified plasma cells and bone marrow multiparameter flow cytometry were employed. A multivariate Cox model showed that chromosome 1 abnormalities, age >75 years and a CD19(+)/CD117(-) immunophenotype of bone marrow plasma cells were independent risk factors for overall survival in elderly patients with newly diagnosed multiple myeloma. Moreover, a detrimental effect of thalidomide, even when administered in association with bortezomib, was observed in patients with abnormal chromosome 1 as well as in those with 17p deletion, while the benefit of adding thalidomide to the bortezomib-melphalan-prednisone regimen was noted in patients carrying an aggressive CD19(+)/CD117(-) bone marrow plasma cell immunophenotype. This trial was registered at www.clinicaltri-als.gov as #NCT01063179. PMID:25015938

  5. Learning beyond graduation: exploring newly qualified specialists' entrance into daily practice from a learning perspective.

    PubMed

    Cuyvers, Katrien; Donche, Vincent; Van den Bossche, Piet

    2016-05-01

    The entrance of newly qualified medical specialists into daily practice is considered to be a stressful period in which curriculum support is absent. Although engaging in both personal and professional learning and development activities is recognized fundamental for lifelong professional competence, research on medical professionals' entrance into practice is scarce. This research aims to contribute to the framework of medical professionals' informal learning and outlines the results of an exploratory study on the nature of learning in daily practice beyond postgraduate training. Eleven newly qualified physicians from different specialized backgrounds participated in a phenomenographic study, using a critical incident method and a grounded theory approach. Results demonstrated that learning in the workplace is, to a large extent, informal and associated with a variety of learning experiences. Analysis shows that experiences related to diagnostics and treatments are important sources for learning. Furthermore, incidents related to communication, changing roles, policy and organization offer learning opportunities, and therefore categorized as learning experiences. A broad range of learning activities are identified in dealing with these learning experiences. More specifically, actively engaging in actions and interactions, especially with colleagues of the same specialty, are the most mentioned. Observing others, consulting written sources, and recognizing uncertainties, are also referred to as learning activities. In the study, interaction, solely or combined with other learning activities, are deemed as very important by specialists in the initial entrance into practice. These insights can be used to develop workplace structures to support the entrance into practice following postgraduate training. PMID:26395113

  6. Executive onboarding: ensuring the success of the newly hired department chair.

    PubMed

    Ross, Warren E; Huang, Karen H C; Jones, Greg H

    2014-05-01

    The success of newly recruited medical school department chairs has become increasingly important for achievement of organizational goals. An effective onboarding program for these chairs can greatly facilitate early success, as well as satisfaction of the new hire with the position and the school. Onboarding programs can include traditional orientation items such as payroll signup and parking details, but should focus heavily on sharing organizational structure, culture, and how things get done. The goals of onboarding will be well served by implementation of three roles in the process. An Orientation Navigator can assist the new chair in the orientation phase, completing new employee documents and navigating the day-to-day challenges of working at the location. A Peer Mentor, generally a sitting chair, serves as both "buddy" and mentor, providing moral support as well as ensuring that the new chair gains an understanding of the people and processes important for getting things done. A Transition Mentor serves over a longer term as a sounding board and coach outside the peer group, assisting in a variety of ways to promote the chair's growth, development, and success as a leader. Finally, any onboarding process is significantly compromised without the active participation of the dean, meeting regularly with the chair to clarify expectations, promote assimilation, and solve problems. Successful onboarding begins with a mindfulness of the needs of the newly hired chair, and a well-designed and well-implemented plan will have wide-ranging benefits for the chair and the organization. PMID:24667516

  7. Deamination of newly-formed dopamine in rat renal tissues.

    PubMed Central

    Fernandes, M. H.; Pestana, M.; Soares-da-Silva, P.

    1991-01-01

    1. The present study has examined the formation of dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) in slices of the rat renal cortex and the renal medulla loaded with exogenous L-beta-3,4-dihydroxyphenylalanine (L-DOPA). The effects of pargyline and of two selective inhibitors of monoamine oxidase (MAO) types A and B, respectively Ro 41-1049 and Ro 19-6327, on the deamination of newly-synthesized dopamine in kidney slices incubated with exogenous L-DOPA were also tested. The assay of L-DOPA, dopamine, noradrenaline and DOPAC was performed by means of h.p.l.c. with electrochemical detection. 2. Incubation of renal slices with exogenous L-DOPA resulted in a concentration-dependent accumulation of dopamine and DOPAC; the tissue levels of newly-formed dopamine and DOPAC in slices of the renal medulla were 6-8% of those in cortical slices. 3. Pargyline (0.1 mM) produced a marked decrease (84% reduction) in the formation of DOPAC in kidney slices loaded with 1.0 mM L-DOPA; this effect was accompanied by a 17% increase in the accumulation of dopamine. Similar effects were obtained at higher concentrations of pargyline (0.5 and 1.0 mM). At 5.0 and 10.0 mM pargyline, a marked decrease (46 and 76% reduction) in the accumulation of newly-formed dopamine was observed. 4. The accumulation of dopamine and DOPAC was found to be time-dependent in experiments in which tissues were incubated with 5 and 10 microM L-DOPA for 5, 10, 20 and 30 min. Pargyline (0.1 mM) produced an increase in the accumulation of dopamine at all incubation periods and decreased the formation of DOPAC.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1364853

  8. Surgical Outcomes of Newly Trained ShangRing Circumcision Providers

    PubMed Central

    Lee, Richard K.; Li, Philip S.; Zulu, Robert; Agot, Kawango; Combes, Stephanie; Simba, Raymond O.; Hart, Catherine; Lai, Jaim Jou; Zyambo, Zude; Goldstein, Marc; Feldblum, Paul J.; Barone, Mark A.

    2016-01-01

    Background: Devices can potentially accelerate scale-up of voluntary medical male circumcision in sub-Saharan Africa. Studies have demonstrated advantages of the ShangRing device over conventional circumcision. With the need to train providers rapidly for scale-up, concerns arise about the transferability of techniques and the expertise of new trainees. Methods: We compared outcomes of ShangRing circumcisions conducted in Kenya by experienced providers (experience with more than 100 ShangRing circumcisions) and newly trained providers (trained in Kenya by the experienced providers before the study began). During training, trainees performed at least 7 ShangRing circumcisions and 3 removals. Newly trained providers received intermittent clinical mentoring initially during the study but otherwise conducted circumcisions on their own. Results: Four hundred six and 115 ShangRing procedures were performed by the new trainees and the experienced providers, respectively. The mean duration of circumcisions was 6.2 minutes for both trained and experienced provider groups (P = 0.45), whereas the mean pain score (on an 11-point scale) was 2.5 and 3.2, respectively (P = 0.65). There was no difference in the proportion of participants healed by the day 42 visit (P = 0.13) nor in the incidence of moderate and severe adverse events observed (P = 0.16). Participants in both groups were equally satisfied with final wound cosmesis. Discussion: Results demonstrate that the ShangRing circumcision technique is easy to learn and master. Newly trained providers can safely conduct ShangRing circumcisions in routine service settings. The ShangRing can facilitate rapid rollout of voluntary medical male circumcision for HIV prevention in sub-Saharan Africa. PMID:27331584

  9. Newly licensed registered nurse job turnover and turnover intent.

    PubMed

    Unruh, Lynn Y; Zhang, Ning Jackie

    2014-01-01

    Through survey data, this study examines job leaving behaviors of newly licensed registered nurses and identifies educational and managerial issues that need to be addressed to retain them. Within 1.5-2.5 years of graduating, one third of all respondents had left their first job, most for work-related reasons. Predictors of job leaving or intentions to leave included not having had a good orientation, information issues, having difficulties doing a good job, not being rewarded fairly, and low job satisfaction. PMID:25237913

  10. Certification document for newly generated contact-handled transuranic waste

    SciTech Connect

    Box, W.D.; Setaro, J.

    1984-01-01

    The US Department of Energy has requested that all national laboratories handling defense waste develop and augment a program whereby all newly generated contact-handled transuranic (TRU) waste be contained, stored, and then shipped to the Waste Isolation Pilot Plant (WIPP) in accordance with the requirements set forth in WIPP-DOE-114. The program described in this report delineates how Oak Ridge National Laboratory intends to comply with these requirements and lists the procedures used by each generator to ensure that their TRU wastes are certifiable for shipment to WIPP.

  11. Inverse Association of Serum Docosahexaenoic Acid With Newly Diagnosed Hypertension

    PubMed Central

    Yang, Bo; Ding, Fang; Wang, Feng-Lei; Yu, Wei; Li, Duo

    2016-01-01

    Abstract Observational studies on circulating fatty acid (FA) and primary prevention of hypertension have yielded inconsistent results, and the association among the Chinese population is not fully clear. The aim of the study was to discern important FAs that can discriminate hypertensive patients from normotensive persons, and investigate associations between the important FAs and risk of hypertension. We conducted a case-control study nested within a community-based cohort of 2447 Chinese participants aged 35 to 79 years who completed a baseline assessment between October 2012 and April 2013. In all, 480 patients with newly diagnosed hypertension were identified at baseline and 480 normotensive individuals were randomly selected as matched normotensive controls. Controls were individually matched to cases by age (±2 y), sex, and recruitment center, with a 1:1 case-to-control ratio. Serum FA profile was compared between cases and controls by orthogonal partial least squares-discriminant analyses. Odds ratio (OR) with 95% confidence interval (CI) for newly diagnosed hypertension was estimated by a conditional logistical analysis. After adjustment for body mass index, education, profession, family history of hypertension, salt intake, heart rate, blood lipids, and fasting glucose levels, serum FA profile in hypertensive patients was typically characterized by higher 16:0 and 16:1n-7, and lower 18:2n-6 and 22:6n-3, compared with normotensive controls. Docosahexaenoic acid (22:6n-3) and palmitoleic acid (16:1n-7) were identified as the important FA contributing most to the intergroup separations. When comparing the highest and lowest quartile of FA composition, newly diagnosed hypertension was negatively associated with 22:6n-3 (OR 0.65; 95% CI, 0.45–0.93; P for trend = 0.02), but positively associated with 16:1n-7 (OR 2.14; 95% CI, 1.46–3.12; P for trend < 0.001). The associations remained pronounced after multiple adjustments and in further stratified

  12. Insights into newly discovered marks and readers of epigenetic information.

    PubMed

    Andrews, Forest H; Strahl, Brian D; Kutateladze, Tatiana G

    2016-08-18

    The field of chromatin biology has been advancing at an accelerated pace. Recent discoveries of previously uncharacterized sites and types of post-translational modifications (PTMs) and the identification of new sets of proteins responsible for the deposition, removal, and reading of these marks continue raising the complexity of an already exceedingly complicated biological phenomenon. In this Perspective article we examine the biological importance of new types and sites of histone PTMs and summarize the molecular mechanisms of chromatin engagement by newly discovered epigenetic readers. We also highlight the imperative role of structural insights in understanding PTM-reader interactions and discuss future directions to enhance the knowledge of PTM readout. PMID:27538025

  13. Acute hemolysis in a patient with a newly diagnosed glioblastoma.

    PubMed

    Murphy, Adrian G; Grossman, Stuart A

    2016-07-01

    We describe a 62-year-old of Egyptian origin who presented with sudden, severe and symptomatic anemia requiring hospitalization shortly after beginning concurrent radiation and temozolomide for his newly diagnosed glioblastoma. He had also recently been started on steroids, anticonvulsants and Pneumocystis jirovecii prophylaxis. He was ultimately diagnosed with G6PD deficiency with an acute hemolytic anemia precipitated by dapsone. Screening for G6PD deficiency should be considered in high-risk patient populations where P. jirovecii prophylaxis is planned. PMID:27230975

  14. Knickkopf protein protects and organizes chitin in the newly synthesized insect exoskeleton

    Technology Transfer Automated Retrieval System (TEKTRAN)

    New cuticle synthesis and molting are complex developmental processes that all insects must undergo to allow for growth. However, little is known about how insects regulate the selective degradation of the old cuticle while leaving the new one intact. In this study we show that in the red flour beet...

  15. Newly Licensed RNs Describe What They Like Best about Being a Nurse

    PubMed Central

    Djukic, Maja; Pellico, Linda H.; Kovner, Christine T.; Brewer, Carol S.

    2011-01-01

    About 25% of newly licensed registered nurses (NLRNs) leave their first job within two years, but only 2% leave the nursing profession in this same timeframe. Therefore, the researchers sought to discover what new nurses like best about being a nurse, in hopes of gaining information that might help facilities to reduce turnover rates. Data were collected between January and March 2009 from 1,152 NLRNs licensed in 15 US states. Krippendorff's method was used to analyze survey responses. Five themes emerged: “providing holistic patient care,” “having an autonomous and collaborative practice,” “using diverse knowledge and skills to impact patient outcomes,” “receiving recognition,” and “having a job that is secure and stimulating.” Strategies are discussed that organizations might employ in helping NLRNs to realize what they best like about their work, which might lead to improved retention rates. PMID:22135734

  16. Newly diagnosed immune thrombocytopenia: update on diagnosis and management.

    PubMed

    Bansal, Deepak; Rajendran, Aruna; Singhi, Sunit

    2014-10-01

    Immune thrombocytopenia (ITP) continues to intrigue pediatricians and hematologists alike. Patients can have a dramatic presentation with wide-spread bleeds over a few days. There is an aura and fear of intra-cranial hemorrhage that drives the physician to recommend and the patient's family to accept drug treatment. Difference of opinion among physicians in the recommendations for treatment is not uncommon, even though recent evidence-based guidelines recommend a conservative, observation-based approach for the majority of patients with newly diagnosed childhood ITP. It is important to note that a specific 'platelet cut-off count', is no longer suggested as an indication by itself to recommend drug therapy. The manuscript is an update on newly diagnosed ITP in children. Recent changes in definitions and recommendations for treatment are highlighted. Pros and cons of 1st line drugs, including corticosteroids, intravenous immunoglobulin and anti-D are listed. Adjunctive therapies for the management of epistaxis and menorrhagia are described. Role of splenic artery embolization and emergency splenectomy in the backdrop of severe thrombocytopenia is discussed. Realistic case scenarios, common errors and frequently asked questions are included for a practical and easy reading. PMID:24091868

  17. Effects of a newly designed apparatus on orthodontic skeletal anchorage

    PubMed Central

    Tozlu, Murat; Nalbantgil, Didem; Ozdemir, Fulya

    2013-01-01

    Objective: An appliance was designed to increase the cortical bone surface contact area of miniscrew implants (MSIs). The purpose of this in vitro study was to evaluate the effects of this appliance on the anchorage force resistance and the stability of orthodontic MSIs. Materials and Methods: A total of 48 MSIs were placed into bone specimens prepared from the ilium of bovines. Half were placed with the newly designed apparatus and half were placed conventionally. All the specimens were subjected to tangential force loading perpendicular to the MSI with lateral displacement of 0.6 mm, using an Instron Universal Testing machine. The maximum removal torque of each tested specimen was also recorded. Both study and control groups were divided into two subgroups based on whether they had thin and thick cortical bone. Results: The test group had statistically higher force anchorage resistance and maximum insertion torque values than the control group (P < 0.001). The results were found to be more significant in cases in which the cortical bone was thin (P < 0.001). Conclusions: Within the limits of this in vitro study, the present findings suggest that the newly designed apparatus might have a favorable effect on MSI stability in patients presenting with thin cortical bone. Clinical studies are necessary to confirm the results that were observed in vitro. PMID:24966734

  18. HOW CAN NEWLY BORN RAPIDLY ROTATING NEUTRON STARS BECOME MAGNETARS?

    SciTech Connect

    Cheng, Quan; Yu, Yun-Wei

    2014-05-10

    In a newly born (high-temperature and Keplerian rotating) neutron star, r-mode instability can lead to stellar differential rotation, which winds the seed poloidal magnetic field (∼10{sup 11} G) to generate an ultra-high (∼10{sup 17} G) toroidal field component. Subsequently, by succumbing to the Tayler instability, the toroidal field could be partially transformed into a new poloidal field. Through such dynamo processes, the newly born neutron star with sufficiently rapid rotation could become a magnetar on a timescale of ∼10{sup 2} {sup –} {sup 3} s, with a surface dipolar magnetic field of ∼10{sup 15} G. Accompanying the field amplification, the star could spin down to a period of ∼5 ms through gravitational wave radiation due to the r-mode instability and, in particular, the non-axisymmetric stellar deformation caused by the toroidal field. This scenario provides a possible explanation for why the remnant neutron stars formed in gamma-ray bursts and superluminous supernovae could be millisecond magnetars.

  19. Chemotherapy in newly diagnosed primary central nervous system lymphoma

    PubMed Central

    Hashemi-Sadraei, Nooshin; Peereboom, David M.

    2010-01-01

    Primary central nervous system lymphoma (PCNSL) accounts for only 3% of brain tumors. It can involve the brain parenchyma, leptomeninges, eyes and the spinal cord. Unlike systemic lymphoma, durable remissions remain uncommon. Although phase III trials in this rare disease are difficult to perform, many phase II trials have attempted to define standards of care. Treatment modalities for patients with newly diagnosed PCNSL include radiation and/or chemotherapy. While the role of radiation therapy for initial management of PCNSL is controversial, clinical trials will attempt to improve the therapeutic index of this modality. Routes of chemotherapy administration include intravenous, intraocular, intraventricular or intra-arterial. Multiple trials have outlined different methotrexate-based chemotherapy regimens and have used local techniques to improve drug delivery. A major challenge in the management of patients with PCNSL remains the delivery of aggressive treatment with preservation of neurocognitive function. Because PCNSL is rare, it is important to perform multicenter clinical trials and to incorporate detailed measurements of long-term toxicities. In this review we focus on different chemotherapeutic approaches for immunocompetent patients with newly diagnosed PCNSL and discuss the role of local drug delivery in addition to systemic therapy. We also address the neurocognitive toxicity of treatment. PMID:21789140

  20. Brainstem Evoked Potential in Newly Diagnosed Patients of Subclinical Hypothyroidism

    PubMed Central

    Sharma, Kirti; Behera, Joshil Kumar; Kumar, Naresh; Sood, Sushma; Madan, Harnam Singh; Das, Sibadatta

    2015-01-01

    Background: Hypothyroidism is known to be associated with impairment of hearing. The hearing impairment may be conductive, sensorineural, or mixed. Aims: The aim is to assess the auditory pathway by brainstem auditory evoked potentials (BAEPs) in newly diagnosed patients of subclinical hypothyroidism and healthy sex- and age-matched controls. Materials and Methods: The study included 25 healthy sex- and age-matched controls (Group I) and 25 patients of newly diagnosed subclinical hypothyroidism (Group II). The recording was taken by using RMS EMG EP MK2 equipment. The unpaired Student's t-test was used and a P value <0.05 was considered significant. Results: Wave V of right ear BAEP in group II was prolonged (6 ± 0.62 ms) compared to group I (5.49 ± 0.26 ms), and wave V of left ear BAEP in group II was prolonged (5.84 ± 0.57 ms) compared to group I (5.47 ± 0.35 ms). There was no significant coefficient of correlation between wave V and inter-peak latency (IPL) I-V compared to thyroid-stimulating hormone (TSH) levels of both the ears. Conclusion: The prolongation of wave V in BAEPs of both ears suggests that the central auditory pathway is affected significantly in subclinical hypothyroid patients. PMID:25973399

  1. Determination of Atterberg limits using newly devised mud press machine

    NASA Astrophysics Data System (ADS)

    Kayabali, Kamil; Akturk, Ozgur; Fener, Mustafa; Ozkeser, Ali; Ustun, Ayla Bulut; Dikmen, Orhan; Harputlugil, Furkan; Asadi, Ramin

    2016-04-01

    Consistency limits are one of the most prominent parameters to be determined in geotechnical investigations. While these limits are akin to one another, different tools determine each one. Each method of determining consistency limits has its own uncertainties, the operator dependency being the top source of uncertainty. Liquid limit (LL) and plastic limit (PL) tests have a number of uncertainties affecting the test results. The very speculative nature of the bead-rolling method for the plastic limit has long been known. Besides this, its results can be barely accepted as quantitative. In the past, a number of attempts have been made to eliminate these setbacks for Atterberg limits. The scope of this investigation is to evaluate the potential of newly developed "mud press method (MPM)" to predict the two consistency limits. The material employed for this investigation covers 275 soils, whose liquid limits range from 28 to 166. The log(a) and 1/b parameters obtained from the MPM method were correlated to results of the conventional methods. The PL and LL for each soil were predicted using empirical forms and were compared with the laboratory values. Remarkably good matches were obtained between the conventionally determined test results and the predicted values for the liquid and plastic limits. The newly developed tool is superior in several aspects to the available conventional methods and tools.

  2. Los Alamos Plutonium Facility newly generated TRU waste certification

    SciTech Connect

    Gruetzmacher, K.; Montoya, A.; Sinkule, B.; Maez, M.

    1997-02-01

    This paper presents an overview of the activities being planned and implemented to certify newly generated contact handled transuranic (TRU) waste produced by Los Alamos National Laboratory`s (LANL`s) Plutonium Facility. Certifying waste at the point of generation is the most important cost and labor saving step in the WIPP certification process. The pedigree of a waste item is best known by the originator of the waste and frees a site from expensive characterization activities such as those associated with legacy waste. Through a cooperative agreement with LANLs Waste Management Facility and under the umbrella of LANLs WIPP-related certification and quality assurance documents, the Plutonium Facility will be certifying its own newly generated waste. Some of the challenges faced by the Plutonium Facility in preparing to certify TRU waste include the modification and addition of procedures to meet WIPP requirements, standardizing packaging for TRU waste, collecting processing documentation from operations which produce TRU waste, and developing ways to modify waste streams which are not certifiable in their present form.

  3. Twelve tips for running teaching programmes for newly qualified doctors.

    PubMed

    Kirkham, Deborah; Baker, Paul

    2012-01-01

    A teaching programme for newly qualified doctors is necessary for their continuing professional development and education. However, guidelines for the logistics and content of such teaching programmes are limited. These 12 tips provide advice and guidance for the creation and development of a successful programme. This article is intended for readers who are involved in teaching; programme directors, administrators, tutors and trainee doctors themselves. The principles included will also be useful for those involved in developing other types of teaching programmes. Engagement of trainees, the education department and other staff in the hospital is crucial for the success of teaching programmes. A culture of attendance and feedback may take time and effort to establish but is absolutely essential for long-term programme viability. Innovative approaches to teaching, a range of teaching staff and coverage of varied clinical and non-clinical topics, all contribute to a strong programme. PMID:22509893

  4. Evaluation of newly formulated Dow Corning 321 dry film lubricant

    NASA Technical Reports Server (NTRS)

    Cook, M.

    1989-01-01

    An evaluation of the newly formulated Dow Corning 321 dry film lubricant was performed. The purpose of the evaluation was to compare lubricating characteristics of Dow Corning 321 (STW4-2955, SCN No. 3) to those of Molykote 321R (STW4-2955). Ten igniter bolts were installed and torqued on test plates using the old formulation thread lubricant (Molykote 321R), and 10 bolts were installed using the new formulation (Dow Corning 321). After bolt removal, no signs of galling were found on any of the bolts or test plates threaded holes. Average torque-load values for each formulation were very close. Test results showed there are no significant differences in lubrication abilities between Molykote 321R and Dow Corning 321. It is recommended that, once current supplies of Molykote 321R are depleted, Dow Corning 321 dry film lubricant be used in place of Molykote 321R as a thread lubricant on redesigned solid rocket motor assemblies.

  5. The Newly Identified T Helper 22 Cells Lodge in Leukemia

    PubMed Central

    Azizi, Gholamreza; Rastegar Pouyani, Mohsen; Navabi, Shadi sadat; Yazdani, Reza; Kiaee, Fatemeh; Mirshafiey, Abbas

    2015-01-01

    Leukemia is a hematological tumor in which the malignant myeloid or lymphoid subsets play a pivotal role. Newly identified T helper cell 22 (Th22) is a subset of CD4+ T cells with distinguished gene expression, function and specific properties apart from other known CD4+ T cell subsets.Th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (IL)-22, IL-13, and tumor necrosis factor-α (TNF-α). The levels of Th22 and cytokine IL-22 are increased and positively related to inflammatory and autoimmune disorders. Recently, several studies have reported the changes in frequency and function of Th22 in acute leukemic disorders as AML and ALL. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of leukemic disease. PMID:26261700

  6. Radiation grafted adsorbents for newly emerging environmental applications

    NASA Astrophysics Data System (ADS)

    Mahmoud Nasef, Mohamed; Ting, T. M.; Abbasi, Ali; Layeghi-moghaddam, Alireza; Sara Alinezhad, S.; Hashim, Kamaruddin

    2016-01-01

    Radiation induced grafting (RIG) is acquired to prepare a number of adsorbents for newly emerging environmental applications using a single route involving RIG of glycidymethacrylate (GMA) onto polyethylene-polypropylene (PE-PP) non-woven fabric. The grafted fabric was subjected to one of three functionalization reactions to impart desired ionic characters. This included treatment with (1) N-dimethyl-D-glucamine, (2) triethylamine and (3) triethylamine and alkalisation with KOH. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) were used to study the changes in chemical and physical structures of the obtained fibrous adsorbents. The potential applications of the three adsorbents for removal of boron from solutions, capturing CO2 from CO2/N2 mixtures and catalysing transesterification of triacetin/methanol to methyl acetate (biodiesel) were explored. The obtained fibrous adsorbents provide potential alternatives to granular resins for the investigated applications and require further development.

  7. Scent-marking in lone wolves and newly formed pairs

    USGS Publications Warehouse

    Rothman, R.J.; Mech, L.D.

    1979-01-01

    Scent-marking was studied in wolves (Canis lupus) along 133 km of tracks in northern Minnesota during winters of 1975 to 1976 and 1976 to 1977 and in two captive packs and four captive pairs for various periods. Lone wolves, which possess neither mates nor territories, rarely marked by raised-leg urination and defaecated and urinated less along roads and trails, where territorial pairs and packs generally marked. Newly formed pairs marked the most, eventually decreasing their rates to those of established packs. Generally, wolves that scent-marked also bred, whereas non-marking wolves usually did not breed. Scent-marking apparently is important to the success of courtship in new pairs and to reproductive synchrony in established pairs, as well as serving a territorial function.

  8. Ocular manifestation of lymphoma in newly diagnosed cats.

    PubMed

    Nerschbach, V; Eule, J C; Eberle, N; Höinghaus, R; Betz, D

    2016-03-01

    Ocular manifestations of lymphoma are described in humans and dogs but rarely in cats. In this prospective study, cats with newly diagnosed and treatment-naïve lymphoma were evaluated concerning clinical stage and ophthalmologic findings. Twenty-six cats were included. In 12 cats (48%), ocular changes were documented. Uveitis anterior and posterior were predominant findings, being present in 58% of affected individuals. Other findings included exophthalmos, corneal surface lesions and chemosis. Eight cats received chemotherapy, two of which had ocular involvement. In these two cats, a complete remission of an anterior and a partial remission of a posterior uveitis were documented. Due to the detection of ocular involvement, a stage migration from stage IV to V occurred in four patients. In the light of these findings, an opthalmological examination may be considered as an important part of staging in feline lymphoma as well as of follow-up examination in affected cats. PMID:24102737

  9. Millisecond newly born pulsars as efficient accelerators of electrons.

    PubMed

    Osmanov, Zaza; Mahajan, Swadesh; Machabeli, George; Chkheidze, Nino

    2015-01-01

    The newly born millisecond pulsars are investigated as possible energy sources for creating ultra-high energy electrons. The transfer of energy from the star rotation to high energy electrons takes place through the Landau damping of centrifugally driven (via a two stream instability) electrostatic Langmuir waves. Generated in the bulk magnetosphere plasma, such waves grow to high amplitudes, and then damp, very effectively, on relativistic electrons driving them to even higher energies. We show that the rate of transfer of energy is so efficient that no energy losses might affect the mechanism of particle acceleration; the electrons might achieve energies of the order of 10(18) eV for parameters characteristic of a young star. PMID:26403155

  10. Millisecond newly born pulsars as efficient accelerators of electrons

    PubMed Central

    Osmanov, Zaza; Mahajan, Swadesh; Machabeli, George; Chkheidze, Nino

    2015-01-01

    The newly born millisecond pulsars are investigated as possible energy sources for creating ultra-high energy electrons. The transfer of energy from the star rotation to high energy electrons takes place through the Landau damping of centrifugally driven (via a two stream instability) electrostatic Langmuir waves. Generated in the bulk magnetosphere plasma, such waves grow to high amplitudes, and then damp, very effectively, on relativistic electrons driving them to even higher energies. We show that the rate of transfer of energy is so efficient that no energy losses might affect the mechanism of particle acceleration; the electrons might achieve energies of the order of 1018 eV for parameters characteristic of a young star. PMID:26403155

  11. Subclassification of Newly Diagnosed Glioblastomas through an Immunohistochemical Approach

    PubMed Central

    Conroy, Siobhan; Kruyt, Frank A. E.; Joseph, Justin V.; Balasubramaniyan, Veerakumar; Bhat, Krishna P.; Wagemakers, Michiel; Enting, Roelien H.; Walenkamp, Annemiek M. E.; den Dunnen, Wilfred F. A.

    2014-01-01

    Molecular signatures in Glioblastoma (GBM) have been described that correlate with clinical outcome and response to therapy. The Proneural (PN) and Mesenchymal (MES) signatures have been identified most consistently, but others including Classical (CLAS) have also been reported. The molecular signatures have been detected by array techniques at RNA and DNA level, but these methods are costly and cannot take into account individual contributions of different cells within a tumor. Therefore, the aim of this study was to investigate whether subclasses of newly diagnosed GBMs could be assessed and assigned by application of standard pathology laboratory procedures. 123 newly diagnosed GBMs were analyzed for the tumor cell expression of 23 pre-identified proteins and EGFR amplification, together allowing for the subclassification of 65% of the tumors. Immunohistochemistry (IHC)-based profiling was found to be analogous to transcription-based profiling using a 9-gene transcriptional signature for PN and MES subclasses. Based on these data a novel, minimal IHC-based scheme for subclass assignment for GBMs is proposed. Positive staining for IDH1R132H can be used for PN subclass assignment, high EGFR expression for the CLAS subtype and a combined high expression of PTEN, VIM and/or YKL40 for the MES subclass. The application of the proposed scheme was evaluated in an independent tumor set, which resulted in similar subclass assignment rates as those observed in the training set. The IHC-based subclassification scheme proposed in this study therefore could provide very useful in future studies for stratification of individual patient samples. PMID:25546404

  12. Effectiveness evaluation of simulative workshops for newly licensed drivers.

    PubMed

    Rosenbloom, Tova; Eldror, Ehud

    2014-02-01

    The current study set to examine the effects of simulator use in driving instruction on newly licensed drivers, comparing the road safety knowledge and reported intended behavior, as well as the actual driving performance of new drivers. Participants consisted of 280 newly licensed driver, of which 140 whose drivers license training included additional simulator-based lessons, and 140 drivers whose training precluded simulator-based lessons. All drivers answered questionnaires pertaining to their intended safe driving behaviors (according to Ajzen's (2000) theory of planned behavior), and to their traffic safety knowledge. Of the initial sample, 40 drivers received actual driving performance evaluation by an expert driving instructor, as well as by in-vehicle data recorders (IVDRs). We assumed that safer drivers report safer driving intentions, demonstrate greater traffic safety knowledge, evaluated as safer drivers by the driving instructor, and display lower and stable driving parameters on the IVDRs. We hypothesized that theoretical driving studies combined with practical training on simulators will elevate the safety level of novices driving. Hierarchical regression analyses on driving intentions indicated that drivers who did not receive simulator-based lessons demonstrated safer driving intentions compared to drivers who received simulator-based lessons. This pattern possibly indicating the drivers who received simulator-based lessons felt more confident in their driving abilities compared to drivers who did not receive simulated training. No significant difference was found in traffic safety knowledge, or in the evaluation of the expert driving instructor. IDVR data comparisons indicated drivers who received simulator-based lessons braked more often and were less prone to headway events, suggesting a more responsive driving style. These findings do not point to any significant advantage or disadvantage of the current simulator-based driving training over

  13. Noncanonical Amino Acid Labeling in Vivo to Visualize and Affinity Purify Newly Synthesized Proteins in Larval Zebrafish

    PubMed Central

    2011-01-01

    Protein expression in the nervous system undergoes regulated changes in response to changes in behavioral states, in particular long-term memory formation. Recently, methods have been developed (BONCAT and FUNCAT), which introduce noncanonical amino acids bearing small bio-orthogonal functional groups into proteins using the cells’ own translational machinery. Using the selective “click reaction”, this allows for the identification and visualization of newly synthesized proteins in vitro. Here we demonstrate that noncanonical amino acid labeling can be achieved in vivo in an intact organism capable of simple learning behavior, the larval zebrafish. We show that azidohomoalanine is metabolically incorporated into newly synthesized proteins, in a time- and concentration-dependent manner, but has no apparent toxic effect and does not influence simple behaviors such as spontaneous swimming and escape responses. This enables fluorescent labeling of newly synthesized proteins in whole mount larval zebrafish. Furthermore, stimulation with a GABA antagonist that elicits seizures in the larval zebrafish causes an increase in protein synthesis throughout the proteome, which can also be visualized in intact larvae. PMID:22347535

  14. Phase I Study of Vandetanib With Radiotherapy and Temozolomide for Newly Diagnosed Glioblastoma

    SciTech Connect

    Drappatz, Jan; Norden, Andrew D.; Wong, Eric T.

    2010-09-01

    Purpose: Increasing evidence has suggested that angiogenesis inhibition might potentiate the effects of radiotherapy and chemotherapy in patients with glioblastoma (GBM). In addition, epidermal growth factor receptor inhibition might be of therapeutic benefit, because the epidermal growth factor receptor is upregulated in GBM and contributes to radiation resistance. We conducted a Phase I study of vandetanib, an inhibitor of vascular endothelial growth factor receptor 2 and epidermal growth factor receptor, in patients with newly diagnosed GBM combined with RT and temozolomide (TMZ). Methods and Materials: A total of 13 GBM patients were treated with vandetanib, radiotherapy, and concurrent and adjuvant TMZ, using a standard '3 + 3' dose escalation. The maximal tolerated dose was defined as the dose with <1 of 6 dose-limiting toxicities during the first 12 weeks of therapy. The eligible patients were adults with newly diagnosed GBM, Karnofsky performance status of {>=}60, normal organ function, who were not taking enzyme-inducing antiepileptic drugs. Results: Of the 13 patients, 6 were treated with vandetanib at a dose of 200mg daily. Of the 6 patients, 3 developed dose-limiting toxicities within the first 12 weeks, including gastrointestinal hemorrhage and thrombocytopenia in 1 patient, neutropenia in 1 patient, and diverticulitis with gastrointestinal perforation in 1 patient. The other 7 patients were treated with 100 mg daily, with no dose-limiting toxicities observed, establishing this dose as the maximal tolerated dose combined with TMZ and RT. Conclusion: Vandetanib can be safely combined with RT and TMZ in GBM patients. A Phase II study in which patients are randomized to vandetanib 100 mg daily with RT and TMZ or RT and TMZ alone is underway.

  15. Newly qualified teachers' visions of science learning and teaching

    NASA Astrophysics Data System (ADS)

    Roberts, Deborah L.

    2011-12-01

    This study investigated newly qualified teachers' visions of science learning and teaching. The study also documented their preparation in an elementary science methods course. The research questions were: What educational and professional experiences influenced the instructor's visions of science learning and teaching? What visions of science learning and teaching were promoted in the participants' science methods course? What visions of science learning and teaching did these newly qualified teachers bring with them as they graduated from their teacher preparation program? How did these visions compare with those advocated by reform documents? Data sources included participants' assignments, weekly reflections, and multi-media portfolio finals. Semi-structured interviews provided the emic voice of participants, after graduation but before they had begun to teach. These data were interpreted via a combination of qualitative methodologies. Vignettes described class activities. Assertions supported by excerpts from participants' writings emerged from repeated review of their assignments. A case study of a typical participant characterized weekly reflections and final multi-media portfolio. Four strands of science proficiency articulated in a national reform document provided a framework for interpreting activities, assignments, and interview responses. Prior experiences that influenced design of the methods course included an inquiry-based undergraduate physics course, participation in a reform-based teacher preparation program, undergraduate and graduate inquiry-based science teaching methods courses, participation in a teacher research group, continued connection to the university as a beginning teacher, teaching in diverse Title 1 schools, service as the county and state elementary science specialist, participation in the Carnegie Academy for the Scholarship of Teaching and Learning, service on a National Research Council committee, and experience teaching a

  16. A Newly Adopted Helicopter Platform for Geophysical and Remote Sensing

    NASA Astrophysics Data System (ADS)

    Meyer, Uwe

    2014-05-01

    The Federal Institute for Geosciences and Natural Resources in Hannover owns a Sikorsky S-76B helicopter for geophysical and remote sensing airborne surveys. This platform has been completely refurbished and in parts newly designed to be fit for easy installations of complex geophysical instruments underneath, upon and within the helicopter. The airborne platform is equipped with a modern basic navigation equipment consisting of several GNSS antennae, state of the art inertial navigation systems, laser altimeter and video camera systems. Different other modules can be added to the helicopter as a state of the art gamma spectrometer, a laser scanner, airborne gravity meters etc. within the cabin. Moreover, external sensing systems as a photogrammetric camera, infraread camera or optional mulitspectral systems can be installed on the outer skin of the cabin. Different kinds of bird systems towed underneath the helicopter can be hooked up using standard cabling, glas fibres or wireless LAN. Available birds are equipped for frequency domain electromagnetics or gradient magnetics (IPHT Jena & Supracon, Jena). Besides, large georadar systems can be installed as well. The helicopter is able as well to carry TEM-gear or system in development. Main survey targets are groundwater systems, mineral deposits and natural hazards.

  17. Climate change and the water cycle in newly irrigated areas.

    PubMed

    Abrahão, Raphael; García-Garizábal, Iker; Merchán, Daniel; Causapé, Jesús

    2015-02-01

    Climate change is affecting agriculture doubly: evapotranspiration is increasing due to increments in temperature while the availability of water resources is decreasing. Furthermore, irrigated areas are expanding worldwide. In this study, the dynamics of climate change impacts on the water cycle of a newly irrigated watershed are studied through the calculation of soil water balances. The study area was a 752-ha watershed located on the left side of the Ebro river valley, in Northeast Spain. The soil water balance procedures were carried out throughout 1827 consecutive days (5 years) of hydrological and agronomical monitoring in the study area. Daily data from two agroclimatic stations were used as well. Evaluation of the impact of climate change on the water cycle considered the creation of two future climate scenarios for comparison: 2070 decade with climate change and 2070 decade without climate change. The main indicators studied were precipitation, irrigation, reference evapotranspiration, actual evapotranspiration, drainage from the watershed, and irrigation losses. The aridity index was also applied. The results represent a baseline scenario in which adaptation measures may be included and tested to reduce the impacts of climate change in the studied area and other similar areas. PMID:25626569

  18. Spread of the newly emerging infectious laryngotracheitis viruses in Australia.

    PubMed

    Agnew-Crumpton, Rebecca; Vaz, Paola K; Devlin, Joanne M; O'Rourke, Denise; Blacker-Smith, Hayley Patricia; Konsak-Ilievski, Barbara; Hartley, Carol A; Noormohammadi, Amir H

    2016-09-01

    Infectious laryngotracheitis (ILT) is a significant viral disease of chickens in many countries around the globe. In this report the status of ILT in Australia has been used as a model to evaluate the evolution of the ILT viruses (ILTVs). Due to its geographical isolation, Australia harbored a distinct lineage of ILT viruses (ILTV) up to 2007. However examination of the ILT viruses (ILTV) involved in outbreaks between 2007 and 2009 has revealed that many of the outbreaks were caused by two new viral genotypes, class 8 and class 9. These two recombinant viruses were found to emerge as a result of recombination between previously existing live vaccine strains (SA2 and A20), and another live vaccine strain (Serva) introduced into the country in 2007. The new recombinant ILTVs were also shown to possess significantly higher virulence and replication capacity compared with a previously predominant ILTV, class 2. In the current study, examination of a large number of ILTVs isolated from outbreaks between 2009 and 2015 revealed the emergence of yet another recombinant virus (class 10) that appears to have become a predominant genotype in New South Wales. In Victoria however, the recombinant class 9 gradually became the predominant virus, replacing class 2. Therefore, there was an unusual pattern in geographical spread of the newly emerged viruses in different states of the country. These results suggest that ILTV is fast evolving towards a greater transmissibility and therefore greater capacity to spread into ILTV-free areas. PMID:27223632

  19. Indicators of distress in newly diagnosed breast cancer patients.

    PubMed

    Chirico, Andrea; Lucidi, Fabio; Mallia, Luca; D'Aiuto, Massimiliano; Merluzzi, Thomas V

    2015-01-01

    Background. The diagnosis, treatment, and long-term management of cancer can present individuals with a multitude of stressors at various points in that trajectory. Psychosocial distress may appear early in the diagnostic process and have negative effects on compliance with treatment and subsequent quality of life. Purpose. The aim of the study was to determine early-phase predictors of distress before any medical treatment. Method. Consistent with the goals of the study, 123 newly diagnosed breast cancer patients (20 to 74 years old) completed multiple indicators of knowledge about breast cancer management and treatment, attitudes toward cancer, social support, coping efficacy, and distress. Results. SEM analysis confirmed the hypothesized model. Age was negatively associated with the patient's knowledge (β = - 0.22), which, in turn, was positively associated with both attitudes toward breast cancer (β = 0.39) and coping self-efficacy (β = 0.36). Self-efficacy was then directly related to psychological distress (β = - 0.68). Conclusions. These findings establish indicators of distress in patients early in the cancer trajectory. From a practical perspective, our results have implications for screening for distress and for the development of early interventions that may be followed by healthcare professionals to reduce psychological distress. PMID:26244115

  20. Current management of newly diagnosed acute promyelocytic leukemia.

    PubMed

    Cicconi, L; Lo-Coco, F

    2016-08-01

    The management of acute promyelocytic leukemia (APL) has considerably evolved during the past two decades. The advent of all-trans retinoic acid (ATRA) and its inclusion in combinatorial regimens with anthracycline chemotherapy has provided cure rates exceeding 80%; however, this widely adopted approach also conveys significant toxicity including severe myelosuppression and rare occurrence of secondary leukemias. More recently, the advent of arsenic trioxide (ATO) and its use in association with ATRA with or without chemotherapy has further improved patient outcome by allowing to minimize the intensity of chemotherapy, thus reducing serious toxicity while maintaining high anti-leukemic efficacy. The advantage of ATRA-ATO over ATRA chemotherapy has been recently demonstrated in two large randomized trials and this option has now become the new standard of care in low-risk (i.e. non-hyperleukocytic) patients. In light of its rarity, abrupt onset and high risk of early death and due to specific treatment requirements, APL remains a challenging condition that needs to be managed in highly experienced centers. We review here the results of large clinical studies conducted in newly diagnosed APL as well as the recommendations for appropriate diagnosis, prevention and management of the main complications associated with modern treatment of the disease. PMID:27084953

  1. Two ways to save a newly learned motor pattern

    PubMed Central

    Bastian, Amy J.

    2015-01-01

    Savings, or faster relearning after initial learning, demonstrates humans' remarkable ability to retain learned movements amid changing environments. This is important within the context of locomotion, as the ability of the nervous system to “remember” how to walk in specific environments enables us to navigate changing terrains and progressively improve gait patterns with rehabilitation. Here, we used a split-belt treadmill to study precisely how people save newly learned walking patterns. In Experiment 1, we investigated savings by systematically varying the learning and unlearning environments. Savings was predominantly influenced by 1) previous exposure to similar abrupt changes in the environment and 2) the amount of exposure to the new environment. Relearning was fastest when these two factors coincided, and we did not observe savings after the environment was introduced gradually during initial learning. In Experiment 2, we then studied whether people store explicit information about different walking environments that mirrors savings of a new walking pattern. Like savings, we found that previous exposure to abrupt changes in the environment also drove the ability to recall a previously experienced walking environment accurately. Crucially, the information recalled was extrinsic information about the learning environment (i.e., treadmill speeds) and not intrinsic information about the walking pattern itself. We conclude that simply learning a new walking pattern is not enough for long-term savings; rather, savings of a learned walking pattern involves recall of the environment or extended training at the learned state. PMID:25855699

  2. Making the Bread: Insights from Newly Synthesized Allohexaploid Wheat.

    PubMed

    Li, Ai-li; Geng, Shuai-Feng; Zhang, Lian-quan; Liu, Deng-cai; Mao, Long

    2015-06-01

    Bread wheat (or common wheat, Triticum aestivum) is an allohexaploid (AABBDD, 2n = 6x = 42) that arose by hybridization between a cultivated tetraploid wheat T. turgidum (AABB, 2n = 4x = 28) and the wild goatgrass Aegilops tauschii (DD, 2n = 2x = 14). Polyploidization provided niches for rigorous genome modification at cytogenetic, genetic, and epigenetic levels, rendering a broader spread than its progenitors. This review summarizes the latest advances in understanding gene regulation mechanisms in newly synthesized allohexaploid wheat and possible correlation with polyploid growth vigor and adaptation. Cytogenetic studies reveal persistent association of whole-chromosome aneuploidy with nascent allopolyploids, in contrast to the genetic stability in common wheat. Transcriptome analysis of the euploid wheat shows that small RNAs are driving forces for homoeo-allele expression regulation via genetic and epigenetic mechanisms. The ensuing non-additively expressed genes and those with expression level dominance to the respective progenitor may play distinct functions in growth vigor and adaptation in nascent allohexaploid wheat. Further genetic diploidization of allohexaploid wheat is not random. Regional asymmetrical gene distribution, rather than subgenome dominance, is observed in both synthetic and natural allohexaploid wheats. The combinatorial effects of diverged genomes, subsequent selection of specific gene categories, and subgenome-specific traits are essential for the successful establishment of common wheat. PMID:25747845

  3. Psychosocial problems among newly diagnosed rheumatoid arthritis patients.

    PubMed

    Gåfvels, C; Hägerström, M; Nordmark, B; Wändell, P E

    2012-03-01

    We identified patients with newly diagnosed rheumatoid arthritis (RA) in the ages 18-65 years who needed psychosocial interventions. A total of 123 patients (90 women) were asked to participate, but 19 declined and 4 dropped out early in the study, leaving a total of 100 patients (75 women) in the sample. Questionnaires used were the Epidemiological Investigation on Rheumatoid Arthritis study questionnaire, the Hospital Anxiety and Depression Scale, the Sense of Coherence (SOC) scale, and the General Coping Questionnaire. Interviews showed that 46% of the included 100 patients had psychosocial problems (PSP). One third of them had problems directly related to RA. The rest had problems with their life situation in general, without or reinforced by RA. Compared to patients without psychosocial problems, PSP patients lived in more strained social situations, especially regarding personal finances and social support. More of the PSP patients were anxious, showed lower SOC scores, and also used more emotion-based coping strategies (resignation, protest, isolation and intrusion) and less problem-oriented (minimization). They also had higher scores on depression and more frequently expected that RA would negatively affect their future. PSP patients also experienced a more negative impact of the disease, a finding not confirmed by the sickness activity score judged by the rheumatologist. Thus, early in the course of RA, screening instruments should be used to identify PSP patients. Psychosocial treatment and support by medical social workers skilled in RA care should be offered. PMID:22089162

  4. Nanoformulation and antimicrobial evaluation of newly synthesized thiouracil derivatives.

    PubMed

    Fadda, Ahmed A; Bayoumy, Nesma M; El-Sherbiny, Ibrahim M

    2016-07-01

    The present work reports the synthesis of a new series of pyridopyrimidine derivatives. The newly synthesized compounds were characterized by various analytical and spectral techniques. In addition, their antimicrobial activity was evaluated as well as modeling studies were performed to investigate their ability to recognize and bind to the biotin carboxylase (BC)-active site. The results showed a broad spectrum antibacterial and antifungal profile of the synthesized derivatives. Docking results demonstrated that all members of this class of new derivatives were able to recognize the active site of Escherichia coli BC and form different types of bonding interactions with key active site amino acid residues. Besides the compounds with promising antimicrobial activity in addition to 6-aminothiouracil, as control, were incorporated into polycaprolactone nanoparticles to improve their water solubility, permeability through physiological barriers and consequently enhanced therapeutic efficacy. The compounds-loaded nanoparticles were prepared using single emulsion-solvent evaporation technique, and their diameters were found to be in the range 136 ± 30 to 213 ± 28 nm. Transmission electron microscopy (TEM) showed a spherical and dense morphology of the nanoparticles. The results also showed high entrapment efficiency of the synthesized bioactive compounds in the nanoparticles (85 ± 5% to 91 ± 2%) with a desirable in vitro biodegradation and release profiles. PMID:26559404

  5. Indicators of distress in newly diagnosed breast cancer patients

    PubMed Central

    Lucidi, Fabio; Mallia, Luca; D’Aiuto, Massimiliano; Merluzzi, Thomas V.

    2015-01-01

    Background. The diagnosis, treatment, and long-term management of cancer can present individuals with a multitude of stressors at various points in that trajectory. Psychosocial distress may appear early in the diagnostic process and have negative effects on compliance with treatment and subsequent quality of life. Purpose. The aim of the study was to determine early-phase predictors of distress before any medical treatment. Method. Consistent with the goals of the study, 123 newly diagnosed breast cancer patients (20 to 74 years old) completed multiple indicators of knowledge about breast cancer management and treatment, attitudes toward cancer, social support, coping efficacy, and distress. Results. SEM analysis confirmed the hypothesized model. Age was negatively associated with the patient’s knowledge (β = − 0.22), which, in turn, was positively associated with both attitudes toward breast cancer (β = 0.39) and coping self-efficacy (β = 0.36). Self-efficacy was then directly related to psychological distress (β = − 0.68). Conclusions. These findings establish indicators of distress in patients early in the cancer trajectory. From a practical perspective, our results have implications for screening for distress and for the development of early interventions that may be followed by healthcare professionals to reduce psychological distress. PMID:26244115

  6. Structural confirmation of oligosaccharides newly isolated from sugar beet molasses

    PubMed Central

    2012-01-01

    Background Sugar beet molasses is a viscous by-product of the processing of sugar beets into sugar. The molasses is known to contain sucrose and raffinose, a typical trisaccharide, with a well-established structure. Although sugar beet molasses contains various other oligosaccharides as well, the structures of those oligosaccharides have not been examined in detail. The purpose of this study was isolation and structural confirmation of these other oligosaccharides found in sugar beet molasses. Results Four oligosaccharides were newly isolated from sugar beet molasses using high-performance liquid chromatography (HPLC) and carbon-Celite column chromatography. Structural confirmation of the saccharides was provided by methylation analysis, matrix-assisted laser desorption/ionaization time of flight mass spectrometry (MALDI-TOF-MS), and nuclear magnetic resonance (NMR) measurements. Conclusion The following oligosaccharides were identified in sugar beet molasses: β-D-galactopyranosyl-(1- > 6)-β-D-fructofuranosyl-(2 <-> 1)-α-D-glucopyranoside (named β-planteose), α-D-galactopyranosyl-(1- > 1)-β-D-fructofuranosyl-(2 <-> 1)-α-D-glucopyranoside (named1-planteose), α-D-glucopyranosyl-(1- > 6)-α-D-glucopyranosyl-(1 <-> 2)-β-D-fructofuranoside (theanderose), and β-D-glucopyranosyl-(1- > 3)-α-D-glucopyranosyl-(1 <-> 2)-β-D-fructofuranoside (laminaribiofructose). 1-planteose and laminaribiofructose were isolated from natural sources for the first time. PMID:22925105

  7. Dispersion of fine phosphor particles by newly developed beads mill

    NASA Astrophysics Data System (ADS)

    Joni, I. Made; Panatarani, C.; Maulana, Dwindra W.

    2016-02-01

    Fine phosphor Y2O3:Eu3+ particles has advanced properties compare to conventional particles applied for compact fluorescent lamp (CFL) as three band phosphor. However, suspension of fine particles easily agglomerated during preparation of spray coating of the CFL tube. Therefore, it is introduced newly developed beads mill system to disperse fine phosphor. The beads mill consist of glass beads, dispersing chamber (impellers), separator chamber, slurry pump and motors. The first important performance of beads mill is the performance of the designed on separating the beads with the suspended fine particles. We report the development of beads mill and its separation performance vary in flow rate and separator rotation speeds. The 27 kg of glass beads with 30 µm in size was poured into dispersing chamber and then water was pumped continuously through the slurry pump. The samples for the separation test was obtained every 1 hours vary in rotation speed and slurry flow rate. The results shows that the separation performance was 99.99 % obtained for the rotation speed of >1000 rpm and flow rate of 8 L/minute. The performances of the system was verified by dispersing fine phosphor Y2O3:Eu3+ particles with concentration 1 wt.%. From the observed size distribution of particles after beads mill, it is concluded that the current design of bead mill effectively dispersed fine phosphor Y2O3:Eu3+.

  8. Newly Commissioned Green Bank Telescope Bags New Pulsars

    NASA Astrophysics Data System (ADS)

    2002-01-01

    Astronomers using the National Science Foundation's newly commissioned Robert C. Byrd Green Bank Telescope (GBT) have discovered a windfall of three previously undetected millisecond pulsars in a dense cluster of stars in the Milky Way Galaxy. The Green Bank Telescope The Robert C. Byrd Green Bank Telescope "This globular cluster, known as Messier 62, has been very well studied, and it would have been an exciting discovery to find just one new pulsar. The fact that we were able to detect three new pulsars at one time is simply remarkable," said Bryan Jacoby, a graduate student at the California Institute of Technology who led the research team. Results of the discovery were recently announced in an International Astronomical Union Circular. Jacoby and his colleague Adam Chandler, also a graduate student at Caltech, used the GBT to search for new pulsars in addition to the three already known in this cluster. Their research was part of the GBT's Early Science Program, which allows scientific investigations during the testing and commissioning of the telescope. The researchers used the Berkeley-Caltech Pulsar Machine, a new instrument whose development was overseen by Donald Backer at the University of California at Berkeley, to process the signals from the GBT and record them for later analysis. After their data were analyzed, the researchers discovered the telltale signatures of three additional pulsars and their white dwarf companion stars. Pulsars are rapidly rotating neutron stars that emit intense beams of radio waves along their misaligned magnetic axes. When these beams intersect the Earth, we see the pulsar flash on and off. Due to their exquisitely steady rotation, pulsars allow astronomers to study the basic laws of physics and the ways in which these dense clusters and exotic stellar systems are formed. Astronomers study globular clusters because they are among the oldest building blocks of our Galaxy. With their very dense stellar populations, these

  9. Hα Surges Initiated by Newly-emerging Satellite Magnetic Fields

    NASA Astrophysics Data System (ADS)

    Wang, Jun-feng; Zhou, Tuan-hui; Ji, Hai-sheng

    2014-01-01

    On July 22, 2011 and in the active region NOAA 11259 there ap- peared the event of the ejection of solar atmospheric Hα surges. According to the full-disc Hα observations of the Big Bear Solar Observatory in United States, three consecutive surges at one and the same place in the north of the main spot of the active region were discovered. The trajectories of these three surges exhib- ited the figure of straight lines, and their integral configuration is like an inverted Eiffel Tower. The first two surges are quite similar, and in each of them there appeared two bright points in the northern part of the main spot. After several minutes, the surges appeared in the midst of bright points. When the bright- ness of the bright points attained the maximum value, the surges spouted out from the midst of bright points. And after reaching the maximum altitude, they quickly vanished. Before the ejection of the third surge took place, no bright points appeared. Besides, its maximal altitude is merely one half of that of the first two surges. Via a comparison with the SDO/HMI (Solar Dynamics Obser- vatory/Helioseismic and Magnetic Imager) data of radial magnetic fields, it is found that in more than one hour before the appearance of the first surge there emerged bipolar magnetic fields in the region of ejection. Besides, in several min- utes before the ejection of each Hα surge the magnetic fluxes of positive polarity diminished. Via our analysis it is found that there appeared reconnections be- tween the newly emerging satellite magnetic fields and the preexisting magnetic fields in the spot, and this caused the continuous ejections of Hα surges.

  10. Clinical Features of Newly Diagnosed Cytomegalovirus Retinitis in Northern Thailand

    PubMed Central

    Ausayakhun, Somsanguan; Keenan, Jeremy D; Ausayakhun, Sakarin; Jirawison, Choeng; Khouri, Claire M; Skalet, Alison H; Heiden, David; Holland, Gary N; Margolis, Todd P

    2011-01-01

    Purpose To characterize the clinical manifestations of cytomegalovirus (CMV) retinitis in northern Thailand. Design Prospective, observational cross-sectional study. Methods We recorded characteristics of 52 consecutive patients newly diagnosed with CMV retinitis at a tertiary university-based medical center in northern Thailand. Indirect ophthalmoscopy by experienced ophthalmologists was supplemented with fundus photography to determine the proportion of eyes with various clinical features of CMV retinitis. Results Of the 52 patients with CMV retinitis, 55.8% were female. All were HIV-positive. The vast majority (90.4%) had started antiretroviral therapy. CMV retinitis was bilateral in 46.2% of patients. Bilateral visual acuity worse than 20/60 was observed in 23.1% of patients. Of 76 eyes with CMV retinitis, 61.8% had zone I disease and 21.6% had lesions involving the fovea. Lesions larger than 25% of the retinal area were observed in 57.5% of affected eyes. CMV retinitis lesions commonly had marked or severe border opacity (47.4% of eyes). Vitreous haze was often present (46.1% of eyes). Visual impairment was more common in eyes with larger retinitis lesions. Retinitis lesion size, used as a proxy for duration of disease, was associated with fulminant appearance (OR 1.24 [1.01 – 1.51]), and marked or severe border opacity (OR 1.36 [1.11 – 1.67]). Based on lesion size, retinitis preceded antiretroviral treatment in each patient. Conclusions Patients presenting to a tertiary medical center in northern Thailand have advanced CMV retinitis, possibly due to delayed diagnosis. Earlier screening and treatment of CMV retinitis may limit progression of disease and prevent visual impairment in this population. PMID:22265148

  11. Hyperinsulinemia in newly diagnosed patients with multiple sclerosis.

    PubMed

    Penesova, Adela; Vlcek, Miroslav; Imrich, Richard; Vernerova, Lucia; Marko, Andrea; Meskova, Milada; Grunnerova, Lucia; Turcani, Peter; Jezova, Daniela; Kollar, Branislav

    2015-08-01

    There are limited data regarding glucose metabolism dysregulation in multiple sclerosis (MS). Present study investigates glucose and insulin response during oral glucose tolerance test (oGTT) in MS patients. We examined 19 MS patients and 19 age, sex and body mass index (BMI) matched healthy controls. MS patients were newly diagnosed, untreated and with low Expanded Disability Status Scale (EDSS) score (1.1 ± 0.7). Plasma glucose, lactate, insulin and GLP-1 during oGTT, and fasting adipokines, lipid and inflammatory parameters were analyzed. Insulin sensitivity indices (ISI) were calculated. MS patients had comparable fasting (5.2 ± 0.3 vs. 5.0 ± 0.4 mmol/l, p = 0.05) and post-load glucose concentrations as controls. Insulin response to oral glucose load in MS was increased (p = 0.022). Insulin sensitivity was lower in MS compared to controls [ISI(Matsuda) 6.95 ± 3.44 vs. 10.60 ± 4.81, p = 0.011 and ISI(Cederholm) 49.9 ± 15.3 vs. 61.3 ± 16.3, p = 0.032]. We did not find any difference in lactate, GLP-1, total, HDL and LDL cholesterol, triglycerides, interleukin 6, tumor necrosis factor, C-reactive protein, resistin, leptin, adiponectin levels between groups. We found decreased insulin sensitivity with postprandial hyperinsulinemia in MS patients, which seems not to be related to chronic inflammation or physical inactivity. The role of hyperinsulinemia in CNS function impairment should be further investigated. PMID:25809135

  12. CAMS newly detected meteor showers and the sporadic background

    NASA Astrophysics Data System (ADS)

    Jenniskens, P.; Nénon, Q.; Gural, P. S.; Albers, J.; Haberman, B.; Johnson, B.; Morales, R.; Grigsby, B. J.; Samuels, D.; Johannink, C.

    2016-03-01

    The Cameras for Allsky Meteor Surveillance (CAMS) video-based meteoroid orbit survey adds 60 newly identified showers to the IAU Working List of Meteor Showers (numbers 427, 445-446, 506-507, and part of 643-750). 28 of these are also detected in the independent SonotaCo survey. In total, 230 meteor showers and shower components are identified in CAMS data, 177 of which are detected in at least two independent surveys. From the power-law size frequency distribution of detected showers, we extrapolate that 36% of all CAMS-observed meteors originated from ∼700 showers above the N = 1 per 110,000 shower limit. 71% of mass falling to Earth from streams arrives on Jupiter-family type orbits. The transient Geminids account for another 15%. All meteoroids not assigned to streams form a sporadic background with highest detected numbers from the apex source, but with 98% of mass falling in from the antihelion source. Even at large ∼7-mm sizes, a Poynting-Robertson drag evolved population is detected, which implies that the Grün et al. collisional lifetimes at these sizes are underestimated by about a factor of 10. While these large grains survive collisions, many fade on a 104-y timescale, possibly because they disintegrate into smaller particles by processes other than collisions, leaving a more resilient population to evolve. The meteors assigned to the various showers are identified in the CAMS Meteoroid Orbit Database 2.0 submitted to the IAU Meteor Data Center, and can be accessed also at

  13. Health status of newly arrived refugees in Toronto, Ont

    PubMed Central

    Redditt, Vanessa J.; Janakiram, Praseedha; Graziano, Daniela; Rashid, Meb

    2015-01-01

    Abstract Objective To determine the prevalence of selected infectious diseases among newly arrived refugee patients and whether there is variation by key demographic factors. Design Retrospective chart review. Setting Primary care clinic for refugee patients in Toronto, Ont. Participants A total of 1063 refugee patients rostered at the clinic from December 2011 to June 2014. Main outcome measures Demographic information (age, sex, and region of birth); prevalence of HIV, hepatitis B, hepatitis C, Strongyloides, Schistosoma, intestinal parasites, gonorrhea, chlamydia, and syphilis infections; and varicella immune status. Results The median age of patients was 29 years and 56% were female. Refugees were born in 87 different countries. Approximately 33% of patients were from Africa, 28% were from Europe, 14% were from the Eastern Mediterranean Region, 14% were from Asia, and 8% were from the Americas (excluding 4% born in Canada or the United States). The overall rate of HIV infection was 2%. The prevalence of hepatitis B infection was 4%, with a higher rate among refugees from Asia (12%, P < .001). Hepatitis B immunity was 39%, with higher rates among Asian refugees (64%, P < .001) and children younger than 5 years (68%, P < .001). The rate of hepatitis C infection was less than 1%. Strongyloides infection was found in 3% of tested patients, with higher rates among refugees from Africa (6%, P = .003). Schistosoma infection was identified in 15% of patients from Africa. Intestinal parasites were identified in 16% of patients who submitted stool samples. Approximately 8% of patients were varicella nonimmune, with higher rates in patients from the Americas (21%, P < .001). Conclusion This study highlights the importance of screening for infectious diseases among refugee patients to provide timely preventive and curative care. Our data also point to possible policy and clinical implications, such as targeted screening approaches and improved access to vaccinations and

  14. Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome

    PubMed Central

    Weller, Michael; Nabors, Louis Burt; Gorlia, Thierry; Leske, Henning; Rushing, Elisabeth; Bady, Pierre; Hicking, Christine; Perry, James; Hong, Yong-Kil; Roth, Patrick; Wick, Wolfgang; Goodman, Simon L.; Hegi, Monika E.; Picard, Martin; Moch, Holger; Straub, Josef; Stupp, Roger

    2016-01-01

    Integrins αvβ3 and αvβ5 regulate angiogenesis and invasiveness in cancer, potentially by modulating activation of the transforming growth factor (TGF)-β pathway. The randomized phase III CENTRIC and phase II CORE trials explored the integrin inhibitor cilengitide in patients with newly diagnosed glioblastoma with versus without O6-methylguanine DNA methyltransferase (MGMT) promoter methylation. These trials failed to meet their primary endpoints. Immunohistochemistry was used to assess the levels of the target integrins of cilengitide, αvβ3 and αvβ5 integrins, of αvβ8 and of their putative target, phosphorylation of SMAD2, in tumor tissues from CENTRIC (n=274) and CORE (n=224). αvβ3 and αvβ5 expression correlated well in tumor and endothelial cells, but showed little association with αvβ8 or pSMAD2 levels. In CENTRIC, there was no interaction between the biomarkers and treatment for prediction of outcome. In CORE, higher αvβ3 levels in tumor cells were associated with improved progression-free survival by central review and with improved overall survival in patients treated with cilengitide. Integrins αvβ3, αvβ5 and αvβ8 are differentially expressed in glioblastoma. Integrin levels do not correlate with the activation level of the canonical TGF-β pathway. αvβ3 integrin expression may predict benefit from integrin inhibition in patients with glioblastoma lacking MGMT promoter methylation. PMID:26918452

  15. Microleakage of newly developed glass carbomer cement in primary teeth

    PubMed Central

    Cehreli, Sevi Burcak; Tirali, R. Ebru; Yalcinkaya, Zeynep; Cehreli, Zafer C.

    2013-01-01

    Objective: Glass carbomer cement represents a new generation of dental material, which mineralizes gradually into fluorapatite. The aim of this study was to evaluate the microleakage and marginal integrity of newly developed glass carbomer cement with and without protective surface coating (SC) in primary molars. Methods: Standardized cavities were prepared on extracted human primary molars, and the teeth were randomly assigned into the following groups (n = 10/each): (1) conventional glass ionomer cement (GIC) without SC; (2) GIC with SC; (3) glass carbomer cement without SC; (4) glass carbomer cement with SC; and (5) compomer without SC. Following thermocycling (5 ± 2°C–55 ± 2°C, dwell time 15 s, 2000×), the specimens were immersed in 0.5% basic fuchsin solution, sectioned, and digitally photographed. Microleakage was evaluated quantitatively by using open-source image analysis toolkit (ImageJ), and the data were analyzed statistically by using Kruskal-Wallis and Conover’s Multiple Comparison tests (P=.05). Results: The greatest amount of dye leakage was observed in the uncoated glass carbomer specimens, followed by the uncoated glass ionomer group (P<.05). There was no significant difference between the microleakage values of coated glass ionomer, coated glass carbomer, and the compomer (P>.05). The following statistical ranking was observed among microleakage of the test materials: uncoated glass carbomer > uncoated glass ionomer > coated glass ionomer ≈ coated glass carbomer ≈ compomer. Uncoated glass carbomer exhibited severe internal ice crack-like lines. Conclusion: The use of the new glass carbomer cement without SC results in severe microleakage and catastrophic internal cracks. PMID:23408469

  16. Ethical issues in organ transplantation.

    PubMed

    Freeman, Richard B; Bernat, James L

    2012-01-01

    We discuss ethical issues of organ transplantation including the stewardship tension between physicians' duty to do everything possible for their patients and their duty to serve society by encouraging organ donation. We emphasize consideration of the role of the principles of justice, utility and equity in the just distribution of transplantable organ as scarce resources. We then consider ethical issues of determining death of the organ donor including the remaining controversies in brain death determination and the new controversies raised by circulatory death determination. We need uniformity in standards of death determination, agreement on the duration of asystole before death is declared, and consensus on the allowable circulatory interventions on the newly declared organ donor that are intended to improve organ function. We discuss the importance of maintaining the dead donor rule, despite the argument of some scholars to abandon it. PMID:23217432

  17. Immigration enhances fast growth of a newly established source population.

    PubMed

    Santoro, Simone; Green, Andy J; Figuerola, Jordi

    2016-04-01

    Abstract. Immigration and local recruitment play a central role in determining the growth rate of breeding populations. Unraveling these processes in newly established pop- ulations is of great importance to increase our understanding of how species change their distributions in response to global change. We studied the largest colony of glossy ibis (Plegadis falcinellus) in Western Europe (established in 1996 in Doñana, SW-Spain) by using capture-recapture methods, count estimates, and projection matrix modeling to: (1) test the effect of resource availability and competition on local recruitment dynamics, (2) investigate the contribution of local recruitment vs. immigration on population growth, and (3) assess the role of this population in source/sink dynamics. We found different dynamics before and after the establishment of satellite colonies in Doñana in 2004. Between 1996 and 2003, the population increased rapidly, fueled by immigrants (≈ 58 breeding females/ yr). Between 2003 and 2007, however, both colony size increase and immigration were negligible. Immigration played a major role in colony growth, but simultaneously this colony was a source population driving expansion of the species range as suggested by (1) absolute and relative estimates of the observed growth rate relative to that predicted by self-recruitment, and (2) numerous observations of Doñana-born individuals breeding elsewhere. Local recruitment, which was particularly high for first-year individuals (probability > 0.8 for the early study years), was not directly related to resource availability or previous-year breeding success. Local recruitment decreased rapidly at a threshold population size, however, when other satellite colonies became established at Dofiana. Our study suggests that even when recruitment at an early age and high productivity are observed, immigration can still play a pivotal role in promoting the fast growth of new populations at the edge of a species range, at

  18. Pharmacotherapy of epilepsy: newly approved and developmental agents.

    PubMed

    Stephen, Linda J; Brodie, Martin J

    2011-02-01

    This article discusses seven newly available antiepileptic drugs (AEDs) and agents in phase III development. Lacosamide, licensed as an adjunctive treatment for partial-onset seizures, primarily acts by enhancing sodium channel slow inactivation. At daily doses of 200-600 mg, the drug significantly reduced partial-onset seizures in adults with refractory epilepsy. The most common adverse effects are CNS related. Rufinamide, available as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome, has an unclear mechanism of action, although it does block voltage-dependent sodium channels. Coadministration of valproic acid significantly increases rufinamide circulating concentrations. The drug has been shown to have efficacy for partial-onset, primary generalized tonic-clonic, tonic-atonic, absence and atypical absence seizures. Adverse effects are mainly somnolence, nausea and vomiting. Eslicarbazepine acetate, a carbamazepine analogue, was recently licensed as adjunctive treatment for partial-onset seizures. Eslicarbazepine acetate acts at voltage-gated sodium channels, although the precise mechanism of action is unclear. The drug had efficacy for partial-onset seizures in three randomized, double-blind, placebo-controlled studies, using 400, 800 or 1200 mg/day. Adverse effects include dizziness and somnolence. Retigabine (ezogabine) exerts its anticonvulsant effect through the opening of neuronal voltage-gated potassium channels. Following significant seizure reduction rates at dosages of 600, 900 and 1200 mg/day, license applications have been submitted for its use as adjunctive treatment for patients with partial-onset seizures. Dose-related adverse effects include somnolence, confusion and dizziness. Brivaracetam is the n-propyl analogue of levetiracetam. Mixed results have been obtained in phase III studies in patients with partial-onset seizures, and further trials in children, patients with photosensitive epilepsy and patients with partial

  19. Geomorphological evolution of a newly restored upland temporary stream

    NASA Astrophysics Data System (ADS)

    Marteau, Baptiste; Batalla, Ramon J.; Gibbins, Chris N.; Green, David R.; Vericat, Damià

    2015-04-01

    The river Ehen, NW England, has been designated as a Special Area of Conservation (SAC) as it hosts England's largest population of freshwater pearl mussels (M. margaritifera). One of the Ehen's main headwater tributary, Ben Gill, was diverted to Ennerdale Lake in the 1970s to help increase the volume of water available for abstraction. Concerns over this diversion on the hydrology and sediment dynamics of the Ehen has led to the reconnection of this temporary stream as part of a project designed to improve habitat conditions for mussels in the Ehen. The reconnection has involved the construction of a new section of channel, following the natural (pre-diversion) course of Ben Gill. This paper presents findings of research designed to track the morphological evolution of the newly created Ben Gill channel. The work follows a previous research in which fluvial dynamics in the Ehen were studied before the reconnection of Ben Gill. Morpho-sedimentary dynamics are analysed at multiple scales: from the movement of individual particles, to changes on channel morphology following competent flow events. Changes in the channel's grain size distributions have been investigated in different sections, while bed mobility has been assessed using a combination of radio frequency identification (RFID) tags inserted into representative particles and painted bed patches. Additionally, digital elevation models (DEMs) of the entire new channel have been constructed by means of automatic digital photogrammetry using high resolution aerial photography taken by an unmanned aerial vehicle (UAV). DEMs of difference (DoD) between major flow events have been used to track lateral and longitudinal changes in the channel at a spatial resolution of less than 5cm. Finally, in order to link sedimentological changes in the new channel to its impact on the main stem Ehen, morpho-sedimentary changes of a gravel bar at the confluence have been monitored combining tracers (i.e. RFID) and repeated

  20. Sediment macroinvertebrate community functioning in impacted and newly-created tidal freshwater habitats

    NASA Astrophysics Data System (ADS)

    Beauchard, Olivier; Jacobs, Sander; Ysebaert, Tom; Meire, Patrick

    2013-03-01

    Although experiencing strong anthropogenic pressures in many estuaries, the ecology of tidal freshwater areas remains largely undocumented. As part of a restoration project in the freshwater zone of the Schelde estuary (Belgium), a new tidal habitat restoration technique (Controlled Reduced Tide system, CRT) was hypothesised to successfully compensate for the impairment of contemporary habitats. The suitability of this newly-created habitat (CRT) and the estuary was investigated over a period of three years for its macroinvertebrate community development. In both the estuary and the CRT, habitats along a flooding gradient were monitored. Differences between the CRT and reference sites in community functioning were explored according to environmental characteristics and organism biological attributes using the RLQ ordination analysis together with the fourth-corner method. Frequently flooded reference sites exhibited environmental characteristics resulting from a hydrological shear stress. In the CRT, after a rapid removal of the terrestrial fauna at low and mid elevations, the low-energy hydrology led to taxonomic and functional enrichment. The RLQ analysis produced significant environmental filtering of biological attributes mainly related to the terrestrial-aquatic transition and to the environmental stressors. This provides an example of life history modification via estuarine ecosystem management.

  1. Rhizoxin analogs contribute to the biocontrol activity of a newly isolated pseudomonas strain.

    PubMed

    Takeuchi, Kasumi; Noda, Naomi; Katayose, Yuichi; Mukai, Yoshiyuki; Numa, Hisataka; Yamada, Kosumi; Someya, Nobutaka

    2015-03-01

    Two strains of Pseudomonas sp., Os17 and St29, were newly isolated from the rhizosphere of rice and potato, respectively, by screening for 2,4-diacetylphloroglucinol producers. These strains were found to be the same species and were the closest to but different from Pseudomonas protegens among the sequenced pseudomonads, based on 16S ribosomal RNA gene and whole-genome analyses. Strain Os17 was as effective a biocontrol agent as reported for P. protegens Cab57, whereas strain St29 was less effective. The whole-genome sequences of these strains were obtained: the genomes are organized into a single circular chromosome with 6,885,464 bp, 63.5% G+C content, and 6,195 coding sequences for strain Os17; and with 6,833,117 bp, 63.3% G+C content, and 6,217 coding sequences for strain St29. Comparative genome analysis of these strains revealed that the complete rhizoxin analog biosynthesis gene cluster (approximately 79 kb) found in the Os17 genome was absent from the St29 genome. In an rzxB mutant, which lacks the polyketide synthase essential for the production of rhizoxin analogs, the growth inhibition activity against fungal and oomycete pathogens and the plant protection efficacy were attenuated compared with those of wild-type Os17. These findings suggest that rhizoxin analogs are important biocontrol factors of this strain. PMID:25496595

  2. Changes in concentration levels of selected VOCs in newly erected and remodelled building in Gdansk.

    PubMed

    Zabiegała, B; Namieśnik, J; Przyk, E; Przyjazny, A

    1999-11-01

    Volatile organic compounds such as benzene, toluene, butyl acetate, ethylbenzene, m-xylene, styrene and m-dichlorobenzene were measured in three newly erected and remodelled dwellings. The present study also attempted to examine the time dependence of concentrations of selected VOCs in each investigated dwelling. This was accomplished by at least triplicate measurements of the IAQ. To collect a series of air samples the active and passive methods were used. In both cases activated charcoal was applied as a sorption medium. The samples were recovered by solvent extraction, and analysed by capillary column gas chromatography, employing a flame ionisation detector. The experimental results showed that MAC values for analysed VOCs were exceeded (even a few orders of magnitude) for the measurements made before inhabiting of the occupants, in every investigated dwelling. The concentrations of the investigated VOCs decreased significantly with time, which should be expected, although in some cases the levels of selected VOCs remained still high. Our experience indicates that parallel application of two different indoor air sampling techniques to determine analytes of interest, though more laborious and time consuming, can lead to significant conclusions concerning indoor air quality in monitored spaces. PMID:10576105

  3. Individual consistency in the behaviors of newly-settled reef fish.

    PubMed

    White, James R; Meekan, Mark G; McCormick, Mark I

    2015-01-01

    Flexibility in behavior is advantageous for organisms that transition between stages of a complex life history. However, various constraints can set limits on plasticity, giving rise to the existence of personalities that have associated costs and benefits. Here, we document a field and laboratory experiment that examines the consistency of measures of boldness, activity, and aggressive behavior in the young of a tropical reef fish, Pomacentrus amboinensis (Pomacentridae) immediately following their transition between pelagic larval and benthic juvenile habitats. Newly-settled fish were observed in aquaria and in the field on replicated patches of natural habitat cleared of resident fishes. Seven behavioral traits representing aspects of boldness, activity and aggression were monitored directly and via video camera over short (minutes), medium (hours), and long (3 days) time scales. With the exception of aggression, these behaviors were found to be moderately or highly consistent over all time scales in both laboratory and field settings, implying that these fish show stable personalities within various settings. Our study is the first to examine the temporal constancy of behaviors in both field and laboratory settings in over various time scales at a critically important phase during the life cycle of a reef fish. PMID:26020013

  4. Performance and characterization of a newly developed self-agitated anaerobic reactor with biological desulfurization.

    PubMed

    Kobayashi, Takuro; Li, Yu-You

    2011-05-01

    The continuous operation of a newly developed methane fermentation reactor, which requires no electricity for the agitation of the fermentation liquid was investigated, and the extent of the biological desulfurization was monitored. Inside the reactor, the continual change in the liquid level and the self-agitation, occurring between 5 and 16 times every day, distributed the organic load near the inlet port of the reactor, as well as providing a nutrient supply to the hydrogen sulfide oxidizing bacteria. At different COD(Cr) loading rates (5, 7, 10 kg m(3)d(-1)), the reactor achieved a biogas production yield of 0.72-0.82 m(3)g(-1)-TS, a COD(Cr) reduction of 79.4-85.5% and an average of 99% hydrogen sulfide removal. This investigation demonstrated that the self-agitated reactor is comparable in digestion performance to the completely stirred tank reactor (CSTR) investigated in a previous study, and that the desulfurization performance was significantly enhanced compared to the CSTR. PMID:21398119

  5. Individual consistency in the behaviors of newly-settled reef fish

    PubMed Central

    Meekan, Mark G.; McCormick, Mark I.

    2015-01-01

    Flexibility in behavior is advantageous for organisms that transition between stages of a complex life history. However, various constraints can set limits on plasticity, giving rise to the existence of personalities that have associated costs and benefits. Here, we document a field and laboratory experiment that examines the consistency of measures of boldness, activity, and aggressive behavior in the young of a tropical reef fish, Pomacentrus amboinensis (Pomacentridae) immediately following their transition between pelagic larval and benthic juvenile habitats. Newly-settled fish were observed in aquaria and in the field on replicated patches of natural habitat cleared of resident fishes. Seven behavioral traits representing aspects of boldness, activity and aggression were monitored directly and via video camera over short (minutes), medium (hours), and long (3 days) time scales. With the exception of aggression, these behaviors were found to be moderately or highly consistent over all time scales in both laboratory and field settings, implying that these fish show stable personalities within various settings. Our study is the first to examine the temporal constancy of behaviors in both field and laboratory settings in over various time scales at a critically important phase during the life cycle of a reef fish. PMID:26020013

  6. PROGRESS REPORT ON THE DSSTOX DATABASE NETWORK: NEWLY LAUNCHED WEBSITE, APPLICATIONS, FUTURE PLANS

    EPA Science Inventory

    Progress Report on the DSSTox Database Network: Newly Launched Website, Applications, Future Plans

    Progress will be reported on development of the Distributed Structure-Searchable Toxicity (DSSTox) Database Network and the newly launched public website that coordinates and...

  7. A national surveillance system for newly acquired HIV infection in Australia. National HIV Surveillance Committee.

    PubMed Central

    McDonald, A M; Gertig, D M; Crofts, N; Kaldor, J M

    1994-01-01

    OBJECTIVES. The purpose of this study was to describe the establishment of a national surveillance system for newly acquired human immunodeficiency virus (HIV) infection and present the first 3 years' results. METHODS. All new cases of diagnosed HIV infection were reported to the national HIV surveillance center through state and territory health authorities. Information sought on each case included evidence of whether the infection had been newly acquired, defined by the diagnosis of HIV seroconversion illness or by the report of a negative or indeterminate HIV antibody test result occurring within the 12 months prior to diagnosis of infection. RESULTS. Of 3602 reported cases of HIV infection in adults and adolescents newly diagnosed in Australia between 1991 and 1993, 11.4% were identified as newly acquired. The majority (85%) of cases of newly diagnosed HIV infection occurred among men who reported homosexual contact, and 15% of these cases were identified as newly acquired. Average age at diagnosis was 31 years for cases of newly acquired infection and 34 years for other cases. CONCLUSIONS. Surveillance for newly acquired HIV infection has been established at a national level in Australia and provides valuable information for planning primary HIV prevention programs. PMID:7998631

  8. 13 CFR 120.812 - Probationary period for newly certified CDCs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Probationary period for newly certified CDCs. 120.812 Section 120.812 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) Certification Procedures to Become A Cdc § 120.812 Probationary period for newly certified CDCs....

  9. Prospective Study of Posttraumatic Stress Disorder in Parents of Children with Newly Diagnosed Type 1 Diabetes.

    ERIC Educational Resources Information Center

    Landolt, Markus A.; Vollrath, Margarete; Laimbacher, Joseph; Gnehm, Hanspeter E.; Sennhauser, Felix H.

    2005-01-01

    Objective: To determine the prevalence, course, and predictors of posttraumatic stress disorder (PTSD) in mothers and fathers of children with newly diagnosed type 1 diabetes. Method: Forty-nine mothers and 48 fathers of 52 children (response rate 65%) with newly diagnosed diabetes (age 6.5-15 years) were assessed at 6 weeks, 6 months, and 12…

  10. 40 CFR 148.17 - Waste specific prohibitions; newly listed wastes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Waste specific prohibitions; newly listed wastes. 148.17 Section 148.17 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) HAZARDOUS WASTE INJECTION RESTRICTIONS Prohibitions on Injection § 148.17 Waste specific prohibitions; newly...

  11. 5 CFR 531.211 - Setting pay for a newly appointed employee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Setting pay for a newly appointed... REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay Setting Pay When Appointment Or Position Changes § 531.211 Setting pay for a newly appointed employee. (a) First appointment. An...

  12. Career Motivation in Newly Licensed Registered Nurses: What Makes Them Remain

    ERIC Educational Resources Information Center

    Banks, Zarata Mann; Bailey, Jessica H.

    2010-01-01

    Despite vast research on newly licensed registered nurses (RNs), we don't know why some newly licensed registered nurses remain in their current jobs and others leave the nursing profession early in their career. Job satisfaction, the most significant factor emerging from the literature, plays a significant role in nurses' decisions to remain in…

  13. Plurilinguism in Teachers' Professionalization: Views of Newly Qualified Pedagogues of Social Work

    ERIC Educational Resources Information Center

    Zascerinskis, Mihails; Aleksejeva, Ludmila; Zascerinska, Jelena

    2012-01-01

    Teachers' professionalization is promoted by language education that includes mother tongue across the curriculum, foreign languages and professional language. Aim of the research is to analyze views of newly qualified pedagogues of social work on languages of professionalization. The object of the present research is views of newly qualified…

  14. Newly Discovered Clouds Found Floating High Above Milky Way

    NASA Astrophysics Data System (ADS)

    2002-10-01

    GREEN BANK, WV -- New studies with the National Science Foundation's Robert C. Byrd Green Bank Telescope (GBT) have revealed a previously unknown population of discrete hydrogen clouds in the gaseous halo that surrounds the Milky Way Galaxy. These clouds were discovered in the transition zone between the Milky Way and intergalactic space, and provide tantalizing evidence that supernova-powered "galactic fountains" continually blast superheated hydrogen gas into our Galactic suburbs. Hydrogen Clouds Graphic Artist's Rendering of the Milky Way (background) with insert showing GBT image of newly-discovered clouds of Hydrogen gas above the plane of the Galaxy. Credit: Kirk Woellert/National Science Foundation. Extending far above the star-filled disk of the Milky Way is an atmosphere, or halo, of hydrogen gas. "By studying this halo, we can learn a great deal about the processes that are going on inside our Galaxy as well as beyond its borders," said Jay Lockman, an astronomer with the National Radio Astronomy Observatory (NRAO) in Green Bank, West Virginia. "It has remained a mystery, however, how this halo formed and what has prevented gravitational forces from collapsing the gas into a thin layer long ago." Some astronomers have speculated that this gas is distributed as a diffuse mist held up by either magnetic fields or cosmic rays streaming out of the plane of the Milky Way. Others believed that it is made of innumerable long-lived hydrogen clouds bobbing up and down like balls tossed by a juggler. Early observations with other telescopes discovered that there was some neutral hydrogen gas floating far above the Galaxy's plane, but these instruments were not sensitive enough to reveal any structure or resolve questions about its origin. Lockman's studies for the first time show a clear picture of the structure of the gas. Rather than a mist, the halo is in fact full of discrete clouds, each containing 50-to-100 solar masses of hydrogen and averaging about 100

  15. Quality of groundwater on the newly dry bottom of the Aral Sea

    NASA Astrophysics Data System (ADS)

    Medeu, A.; Turtabayev, S.; Kurbaniyazov, A.

    2010-05-01

    Anthropogenic impacts on the groundwater can be quantified through the concentrations of non-organic and organic pollutants. We report results of chemical analyses of the water samples collected recently from groundwater wells on the newly dry bottom of the Aral Sea, a well as the Sea itself, and Amudarya River deltaic region. Of all the contaminants, the most important role in the Aral Sea region belongs to nitrates. The content of nitrates in the groundwater generally spans between 50 and 155 mg/l. At the same time, the water of the Aral Sea itself at different locations contained from 93 to 136 mg/l, while the tributary river (Amudarya) water was characterized by concentrations from 181 to 248 mg/l. The highest concentrations of nitrates were observed in the water sample collected from the nearby Sudochye Lake, i.e., 620 mg/l. These figures point towards very significant pollution resulting from agricultural fertilization. The level of pollution in the groundwater appears to be somewhat lower than that in the surface waters. Pollution of groundwater is also manifested in contents of some microcomponents, namely, Co, Cd, Pb, Mn, and Sr. The respective average contents of these elements in the analyzed groundwater samples were 1.7 mg/l, 0.9 mg/l, 0.16 mg/l, 0.2 mg/l, and 10.0 mg/l. The average mineralization of the groundwater was 65 g/l. The accumulation of heavy metals is likely to have been mainly associated with agricultural chemicals and/or mineral fertilizers. The more mobile components, such as Co and Sr, apparently migrated following the retreat of the Sea's shoreline, while the less mobile ones were mainly accumulated in the areas of irrigation and agriculture.

  16. Phase II Trial of Hypofractionated IMRT With Temozolomide for Patients With Newly Diagnosed Glioblastoma Multiforme

    SciTech Connect

    Reddy, Krishna; Damek, Denise; Gaspar, Laurie E.; Ney, Douglas; Waziri, Allen; Lillehei, Kevin; Stuhr, Kelly; Kavanagh, Brian D.; Chen Changhu

    2012-11-01

    Purpose: To report toxicity and overall survival (OS) in patients with newly diagnosed glioblastoma multiforme (GBM) treated with hypofractionated intensity-modulated radiotherapy (hypo-IMRT) with concurrent and adjuvant temozolomide (TMZ). Methods and Materials: Patients with newly diagnosed GBM after biopsy or resection and with adequate performance status and organ or bone marrow function were eligible for this study. Patients received postoperative hypo-IMRT to the surgical cavity and residual tumor seen on T1-weighted brain MRI with a 5-mm margin to a total dose of 60 Gy in 10 fractions (6 Gy/fraction) and to the T2 abnormality on T2-weighted MRI with 5-mm margin to 30 Gy in 10 fractions (3 Gy/fraction). Concurrent TMZ was given at 75 mg/m{sup 2}/day for 28 consecutive days. Adjuvant TMZ was given at 150 to 200 mg/m{sup 2}/day for 5 days every 28 days. Toxicities were defined using Common Terminology Criteria for Adverse Events version 3.0. Results: Twenty-four patients were treated, consisting of 14 men, 10 women; a median age of 60.5 years old (range, 27-77 years); and a median Karnofsky performance score of 80 (range, 60-90). All patients received hypo-IMRT and concurrent TMZ according to protocol, except for 2 patients who received only 14 days of concurrent TMZ. The median number of adjuvant TMZ cycles was 6.5 (range, 0-14).With a median follow-up of 14.8 months (range, 2.7-34.2 months) for all patients and a minimum follow-up of 20.6 months for living patients, no instances of grade 3 or higher nonhematologic toxicity were observed. The median OS was 16.6 months (range, 4.1-35.9 months). Six patients underwent repeated surgery for suspected tumor recurrence; necrosis was found in 50% to 100% of the resected specimens. Conclusion: In selected GBM patients, 60 Gy hypo-IMRT delivered in 6-Gy fractions over 2 weeks with concurrent and adjuvant TMZ is safe. OS in this small cohort of patients was comparable to that treated with current standard of care

  17. Dynamics of photochemical and microbial processing of newly exposed terrestrial DOM in arctic surface waters (Invited)

    NASA Astrophysics Data System (ADS)

    Cory, R. M.; Kling, G. W.

    2010-12-01

    Surface freshwaters act as conduits of terrestrially derived carbon to the atmosphere, and are susceptible to climate change impacts on the water and carbon cycles. For example, climate change in the Arctic is causing melting permafrost, thermokarst failures, and increased fire, all of which will release previously frozen or buried carbon to surface waters as dissolved organic matter (DOM). As previously-frozen DOM is released into relatively warm sunlit surface waters, photodegradation is expected to enhance the rates of DOM processing by bacteria. This close-coupled synergism between photo and bio-oxidation of the DOM is likely particularly important in the Arctic where photochemical interactions abound in the shallow, unshaded streams that transport DOM across the landscape. To test this, we manipulated the UV light exposure of freshly exposed DOM and measured the responses in bacterial production and respiration and characterized the DOM with parallel factor analysis (PARAFAC) of fluorescence spectra. Exposure to light significantly enhanced bacterial processing of DOM, and the magnitude of the positive response was greater for recently exposed DOM compared to resident surface water DOM. These results suggest that turnover rates of newly released DOM depend on water residence time in sunlit surface waters. However, how water movement from soils to small streams and lakes controls the coupled photo- and bio-degradation of DOM is too poorly known to predict the fate of DOM, either to the atmosphere as CO2 or to the ocean as altered, recalcitrant carbon. As a first step in evaluating these hydro-bio-photo linkages and controls, we used DOM fluorescence as a proxy to trace the source and estimate the lability of the DOM in natural and thermokarst-disturbed environments. Results showed that the chemistry and reactivity of DOM was altered by both light exposure (as expected) and also by microbial processing even over short time periods similar to water residence

  18. Generalization of visual regularities in newly hatched chicks (Gallus gallus).

    PubMed

    Santolin, Chiara; Rosa-Salva, Orsola; Regolin, Lucia; Vallortigara, Giorgio

    2016-09-01

    Evidence of learning and generalization of visual regularities in a newborn organism is provided in the present research. Domestic chicks have been trained to discriminate visual triplets of simultaneously presented shapes, implementing AAB versus ABA (Experiment 1), AAB versus ABB and AAB versus BAA (Experiment 2). Chicks distinguished pattern-following and pattern-violating novel test triplets in all comparisons, showing no preference for repetition-based patterns. The animals generalized to novel instances even when the patterns compared were not discriminable by the presence or absence of reduplicated elements or by symmetry (e.g., AAB vs. ABB). These findings represent the first evidence of learning and generalization of regularities at the onset of life in an animal model, revealing intriguing differences with respect to human newborns and infants. Extensive prior experience seems to be unnecessary to drive the process, suggesting that chicks are predisposed to detect patterns characterizing the visual world. PMID:27287627

  19. Clinical, electrocardiographic and echocardiographic abnormalities in Latin American migrants with newly diagnosed Chagas disease 2005-2009, Barcelona, Spain.

    PubMed

    Valerio, L; Roure, S; Sabria, M; Balanzo, X; Valles, X; Seres, L

    2011-01-01

    Following Latin American migration, Chagas disease has inevitably appeared in non-endemic countries in Europe and elsewhere. New policies are necessary to prevent transmission in those countries but the long, often undetected chronic period of the early stages of the disease also renders epidemiological studies important. The main objective of our study was to determine the presence of clinical, electrocardiogram (ECG) and echocardiographic abnormalities in a population of Latin American migrants infected with Trypanosoma cruzi at the moment of diagnosis. We performed a hospital-based observational study of 100 adult patients with newly diagnosed Chagas infection between January 2005 and December 2009. Thirty-seven patients were classified within the Brazilian Consensus on Chagas cardiomyopathy early cardiac stages (A or B1) and 49 presented pathological findings (stage B2) according to the Panamerican Health Organization Classification. Overall, 49 patients showed ECG and/or echocardiographic alterations. The presence of ECG and ecocardiographic alterations were significantly associated (p=0.038). The most frequent ECG and echocardiographic findings were right bundle branch block (12 cases) and impaired left ventricular wall relaxation (24 cases), respectively. In conclusion, ECG and echocardiographic alterations coherent with Chagas cardiomyopathy were found in a large proportion of newly diagnosed Latin American migrants infected with T. cruzi. In the mid-term, Chagas disease might become an important cause of chronic cadiomyopathy in our attendance area. PMID:21958530

  20. Organ Donation

    MedlinePlus

    Organ donation takes healthy organs and tissues from one person for transplantation into another. Experts say that the organs ... and bone marrow Cornea Most organ and tissue donations occur after the donor has died. But some ...

  1. Matching Organs

    MedlinePlus

    ... UNet electronically links all transplant hospitals and organ procurement organizations in a secure, real-time environment. Because ... is identified, a transplant coordinator from an organ procurement organization accesses the UNet system and enters necessary ...

  2. Evaluation of Three Porous Pavement Systems in a Newly Constructed Parking Lot

    EPA Science Inventory

    This project examines porous pavement systems in a newly constructed parking lot next to Building 205 at the Edison Environmental Center. Porous pavement systems are one means of promoting environmental sustainability through stormwater runoff reduction. This project examines t...

  3. Indothrix Krombein, 1957 (Hymenoptera, Chrysididae) newly recorded genus from China, with description of one new species.

    PubMed

    Li, Shuang-Shuang; Xu, Zai-Fu

    2016-01-01

    The genus Indothrix Krombein, 1957 is newly recorded from China. Indothrix brevicornis Li & Xu, sp. nov. (China: Zhejiang) is described and illustrated. Key to the three world species of the genus is given. PMID:27515605

  4. Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes.

    PubMed

    Efficace, Fabio; Gaidano, Gianluca; Breccia, Massimo; Criscuolo, Marianna; Cottone, Francesco; Caocci, Giovanni; Bowen, David; Lübbert, Michael; Angelucci, Emanuele; Stauder, Reinhard; Selleslag, Dominik; Platzbecker, Uwe; Sanpaolo, Grazia; Jonasova, Anna; Buccisano, Francesco; Specchia, Giorgina; Palumbo, Giuseppe A; Niscola, Pasquale; Wan, Chonghua; Zhang, Huiyong; Fenu, Susanna; Klimek, Virginia; Beyne-Rauzy, Odile; Nguyen, Khanh; Mandelli, Franco

    2015-02-01

    The primary objective of this study was to investigate factors associated with fatigue severity in newly diagnosed patients with higher-risk myelodysplastic syndromes (MDS). The secondary objectives were to assess symptom prevalence and to examine the relationships between fatigue, quality of life (QoL) and overall symptom burden in these patients. The analyses were conducted in 280 higher-risk MDS patients. Pre-treatment patient-reported fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale and QoL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Female gender (P = 0·018), poor performance status (i.e., ECOG of 2-4) (P < 0·001) and lower levels of haemoglobin (Hb) (P = 0·026) were independently associated with higher fatigue severity. The three most prevalent symptoms were as follows: fatigue (92%), dyspnoea (63%) and pain (55%). Patients with higher levels of fatigue also had greater overall symptom burdens. The mean global QoL scores of patients with the highest versus those with the lowest levels of fatigue were 29·2 [standard deviation (SD), 18·3] and 69·0 (SD, 18·8), respectively and this difference was four times the magnitude of a clinically meaningful difference. Patient-reported fatigue severity revealed the effects of disease burden on overall QoL more accurately than did degree of anaemia. Special attention should be given to the female patients in the management of fatigue. PMID:25272332

  5. Describing a residency program developed for newly graduated nurse practitioners employed in retail health settings.

    PubMed

    Thabault, Paulette; Mylott, Laura; Patterson, Angela

    2015-01-01

    Retail health clinics are an expanding health care delivery model and an emerging new practice site for nurse practitioners (NPs). Critical thinking skills, clinical competence, interprofessional collaboration, and business savvy are necessary for successful practice in this highly independent and autonomous setting. This article describes a pilot residency partnership program aimed at supporting new graduate NP transition to practice, reducing NP turnover, and promoting academic progression. Eight new graduate NPs were recruited to the pilot and paired with experienced clinical NP preceptors for a 12-month program that focused on increasing clinical and business competence in the retail health setting. The residency program utilized technology to facilitate case conferences and targeted Webinars to enhance learning and peer-to-peer sharing and support. An on-line doctoral-level academic course that focused on interprofessional collaboration in health care, population health, and business concepts was offered. Both NPs and preceptors were highly satisfied with the academic-service residency program between MinuteClinic and Northeastern University School of Nursing in Boston, MA. New NPs particularly valued the preceptor model, the clinical case conferences, and business Webinars. Because their priority was in gaining clinical experience and learning the business acumen relevant to managing the processes of care, they did not feel ready for the doctoral course and would have preferred to take later in their practice. The preceptors valued the academic course and felt that it enhanced their precepting and leadership skills. At the time of this article, 6 months post completion of the residency program, there has been no turnover. Our experience supports the benefits for residency programs for newly graduated NPs in retail settings. The model of partnering with academia by offering a course within a service organization's educational programs can enable academic

  6. Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets.

    PubMed

    Højberg, Ole; Canibe, Nuria; Poulsen, Hanne Damgaard; Hedemann, Mette Skou; Jensen, Bent Borg

    2005-05-01

    Dietary doses of 2,500 ppm ZnO-Zn reduced bacterial activity (ATP accumulation) in digesta from the gastrointestinal tracts of newly weaned piglets compared to that in animals receiving 100 ppm ZnO-Zn. The amounts of lactic acid bacteria (MRS counts) and lactobacilli (Rogosa counts) were reduced, whereas coliforms (MacConkey counts) and enterococci (Slanetz counts, red colonies) were more numerous in animals receiving the high ZnO dose. Based on 16S rRNA gene sequencing, the colonies on MRS were dominated by three phylotypes, tentatively identified as Lactobacillus amylovorus (OTU171), Lactobacillus reuteri (OTU173), and Streptococcus alactolyticus (OTU180). The colonies on Rogosa plates were dominated by the two Lactobacillus phylotypes only. Terminal restriction fragment length polymorphism analysis supported the observations of three phylotypes of lactic acid bacteria dominating in piglets receiving the low ZnO dose and of coliforms and enterococci dominating in piglets receiving the high ZnO dose. Dietary doses of 175 ppm CuSO(4)-Cu also reduced MRS and Rogosa counts of stomach contents, but for these animals, the numbers of coliforms were reduced in the cecum and the colon. The influence of ZnO on the gastrointestinal microbiota resembles the working mechanism suggested for some growth-promoting antibiotics, namely, the suppression of gram-positive commensals rather than potentially pathogenic gram-negative organisms. Reduced fermentation of digestible nutrients in the proximal part of the gastrointestinal tract may render more energy available for the host animal and contribute to the growth-promoting effect of high dietary ZnO doses. Dietary CuSO(4) inhibited the coliforms and thus potential pathogens as well, but overall the observed effect of CuSO(4) was limited compared to that of ZnO. PMID:15870311

  7. CHHBP: a newly identified receptor of crustacean hyperglycemic hormone.

    PubMed

    Li, Ran; Tian, Jin-Ze; Zhuang, Cui-Heng; Zhang, Yi-Chen; Geng, Xu-Yun; Zhu, Li-Na; Sun, Jin-Sheng

    2016-04-15

    Crustacean hyperglycemic hormone (CHH) is a neurohormone found only in arthropods that plays a pivotal role in the regulation of hemolymph glucose levels, molting and stress responses. Although it was determined that a membrane guanylyl cyclase (GC) acts as the CHH receptor in the Y-organ during ecdysteroidogenesis, the identity of the CHH receptor in the hepatopancreas has not been established. In this study, we identified CHH binding protein (CHHBP), as a potential receptor by screening the annotated unigenes from the transcriptome of ITALIC! Eriocheir sinensis, after removal of the eyestalk. Analysis of the binding affinity between CHH and CHHBP provided direct evidence that CHH interacts with CHHBP in a specific binding mode. Subsequent analysis showed that CHHBP is expressed primarily in the hepatopancreas where it localizes to the cell membrane. In addition, real-time PCR analysis showed that ITALIC! CHHBPtranscript levels gradually increase in the hepatopancreas following eyestalk ablation. RNAi-mediated suppression of ITALIC! CHHBPexpression resulted in decreased glucose levels. Furthermore, the reduction of blood glucose induced by ITALIC! CHHBPRNAi reached the same level as that observed in the eyestalk ablation group, suggesting that CHHBP is involved in glucose metabolism regulated by CHH. In addition, compared with the control group, injection of CHH was unable to rescue the decreased glucose levels in ITALIC! CHHBPRNAi crabs. CHH induced transport of 2-NBDG to the outside of cells, with indispensable assistance from CHHBP. Taken together, these findings suggest that CHHBP acts as one type of the primary signal processor of CHH-mediated regulation of cellular glucose metabolism. PMID:26896539

  8. Tentative identification of a newly discovered class of material on Io

    NASA Technical Reports Server (NTRS)

    Trafton, L.

    1991-01-01

    A newly discovered absorption feature in Io's spectrum at 2.1253 microns promises to reveal significant insights in the nature of the interaction among Io's surface, atmosphere, and volcanoes. The most likely candidate for this feature appears to be clusters of CO2 molecules. Observations are underway on a current series of occultations and eclipses of Io by other Galilean satellites in order to locate the source of this newly discovered material on Io, which should provide further clues to its origin.

  9. The stereoconfiguration of newly formed molecules of bis(monoacylglycero)phosphate in BHK cells.

    PubMed

    Joutti, A

    1979-10-26

    Newly formed molecules of bis(monoacylglycero)phosphate (known also as lysobisphosphatidic acid), which were labeled with 32Pi in cultured BHK cells during relatively short pulses, were subjected to stereoanalysis. In contrast to the high proportion of sn-1-glycerophosphate residues in the bulk of the bis(monoacylglycero)phosphate molecules, the newly formed molecules were rich in sn-3-glycerophosphate residues. PMID:508774

  10. Surviving at a distance: organ specific metastasis

    PubMed Central

    Obenauf, Anna C.; Massagué, Joan

    2015-01-01

    The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer related mortality. Once established, metastasis is devastating, yet only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ specific and consequently demand distinct mechanisms for metastatic colonization. Here we review the metastatic traits that allow cancer cells to colonize distinct organ sites. PMID:26693180

  11. How Will This Help Me? Evaluating an Accredited Programme to Enhance the Early Professional Development of Newly Qualified Teachers

    ERIC Educational Resources Information Center

    Rhodes, Christopher; Nevill, Alan; Allan, Jo

    2005-01-01

    This article reports on the evaluation of an accredited programme to enhance the early professional development of newly qualified teachers within the Black Country region of the English West Midlands. Newly qualified teachers participating in the accredited programme, their induction tutors, newly qualified teachers not participating in the…

  12. Additions to the ICSBEP and IRPhEP Handbooks since NCSD 2009

    SciTech Connect

    John D. Bess; J. Blair Briggs; Jim Gulliford; Ian Hill

    2013-10-01

    High-quality integral benchmark experiments have always been a priority for criticality safety. However, interest in integral benchmark data is increasing as efforts to quantify and reduce calculational uncertainties accelerate to meet the demands of future criticality safety needs to support next generation reactor and advanced fuel cycle concepts. The importance of drawing upon existing benchmark data is becoming more apparent because of dwindling availability of critical facilities worldwide and the high cost of performing new experiments. Integral benchmark data from the International Handbook of Evaluated Criticality Safety Benchmark Experiments and the International Handbook of Reactor Physics Benchmark Experiments are widely used. Significant Benchmark data have been added to those two handbooks since the last Nuclear Criticality Safety Division Topical Meeting in Richland, Washington (September 2009). This paper highlights those additions.

  13. RECENT ADDITIONS OF CRITICALITY SAFETY RELATED INTEGRAL BENCHMARK DATA TO THE ICSBEP AND IRPHEP HANDBOOKS

    SciTech Connect

    J. Blair Briggs; Lori Scott; Yolanda Rugama; Enrico Sartori

    2009-09-01

    High-quality integral benchmark experiments have always been a priority for criticality safety. However, interest in integral benchmark data is increasing as efforts to quantify and reduce calculational uncertainties accelerate to meet the demands of future criticality safety needs to support next generation reactor and advanced fuel cycle concepts. The importance of drawing upon existing benchmark data is becoming more apparent because of dwindling availability of critical facilities worldwide and the high cost of performing new experiments. Integral benchmark data from the International Handbook of Evaluated Criticality Safety Benchmark Experiments and the International Handbook of Reactor Physics Benchmark Experiments are widely used. Benchmark data have been added to these two handbooks since the last Nuclear Criticality Safety Division Topical Meeting in Knoxville, Tennessee (September 2005). This paper highlights these additions.

  14. ORGANIC CONTAMINANTS

    EPA Science Inventory

    Organic pollutants may constitute the most widespread waste loadings into the waters of Lake Superior. There are essentially three categories of organic contaminants. The first grouping consists of those organic compounds that readily degrade biologically or chemically. The secon...

  15. Transitioning organic synthesis from organic solvents to water. What's your E Factor?

    PubMed Central

    Lipshutz, Bruce H.; Ghorai, Subir

    2014-01-01

    Traditional organic chemistry, and organic synthesis in particular, relies heavily on organic solvents, as most reactions involve organic substrates and catalysts that tend to be water-insoluble. Unfortunately, organic solvents make up most of the organic waste created by the chemical enterprise, whether from academic, industrial, or governmental labs. One alternative to organic solvents follows the lead of Nature: water. To circumvent the solubility issues, newly engineered “designer” surfactants offer an opportunity to efficiently enable many of the commonly used transition metal-catalyzed and related reactions in organic synthesis to be run in water, and usually at ambient temperatures. This review focuses on recent progress in this area, where such amphiphiles spontaneously self-aggregate in water. The resulting micellar arrays serve as nanoreactors, obviating organic solvents as the reaction medium, while maximizing environmental benefits. PMID:25170307

  16. Newly-formed emotional memories guide selective attention processes: Evidence from event-related potentials.

    PubMed

    Schupp, Harald T; Kirmse, Ursula; Schmälzle, Ralf; Flaisch, Tobias; Renner, Britta

    2016-01-01

    Emotional cues can guide selective attention processes. However, emotional stimuli can both activate long-term memory representations reflecting general world knowledge and engage newly formed memory representations representing specific knowledge from the immediate past. Here, the self-completion feature of associative memory was utilized to assess the regulation of attention processes by newly-formed emotional memory. First, new memory representations were formed by presenting pictures depicting a person either in an erotic pose or as a portrait. Afterwards, to activate newly-built memory traces, edited pictures were presented showing only the head region of the person. ERP recordings revealed the emotional regulation of attention by newly-formed memories. Specifically, edited pictures from the erotic compared to the portrait category elicited an early posterior negativity and late positive potential, similar to the findings observed for the original pictures. A control condition showed that the effect was dependent on newly-formed memory traces. Given the large number of new memories formed each day, they presumably make an important contribution to the regulation of attention in everyday life. PMID:27321471

  17. Newly-formed emotional memories guide selective attention processes: Evidence from event-related potentials

    PubMed Central

    Schupp, Harald T.; Kirmse, Ursula; Schmälzle, Ralf; Flaisch, Tobias; Renner, Britta

    2016-01-01

    Emotional cues can guide selective attention processes. However, emotional stimuli can both activate long-term memory representations reflecting general world knowledge and engage newly formed memory representations representing specific knowledge from the immediate past. Here, the self-completion feature of associative memory was utilized to assess the regulation of attention processes by newly-formed emotional memory. First, new memory representations were formed by presenting pictures depicting a person either in an erotic pose or as a portrait. Afterwards, to activate newly-built memory traces, edited pictures were presented showing only the head region of the person. ERP recordings revealed the emotional regulation of attention by newly-formed memories. Specifically, edited pictures from the erotic compared to the portrait category elicited an early posterior negativity and late positive potential, similar to the findings observed for the original pictures. A control condition showed that the effect was dependent on newly-formed memory traces. Given the large number of new memories formed each day, they presumably make an important contribution to the regulation of attention in everyday life. PMID:27321471

  18. Organization and management of space grant programs

    NASA Technical Reports Server (NTRS)

    Sheppard, Sallie; Nichols, Steve

    1990-01-01

    The 21 Space Grant Programs represent a broad range of organizational structures which operate programs ranging in size from single university organizations to organizations including up to 41 members involving a composite of industrial organizations such as state agencies, and universities. Some of the space grant awards were made to organizations already in existence with on-going programs while other awards were made to consortia newly formed for the purpose of applying to the Space Grant Program. The workshop on organization and management of Space Grant Programs provided an opportunity for directors and program representatives to discuss and compare the relative advantages and disadvantages of the various models being used. This paper offers examples of the diversity of organizations, summarizes the common concerns to be met by each organizational model, and provides a case study of the Texas Space Grant Consortium organization.

  19. Organ Facts

    MedlinePlus

    ... Donation Home / Before The Transplant / Organ Facts Organ Facts Heart Lung Heart/Lung Kidney Pancreas Kidney/Pancreas Liver ... Receiving "the call" About the Operation Heart Lung Heart/Lung Kidney Pancreas Kidney/Pancreas Liver Intestine Organ Facts Here you can find valuable information about organs ...

  20. Organ Donation

    MedlinePlus

    ... healthy organs and tissues from one person for transplantation into another. Experts say that the organs from one donor can save or help as many as 50 people. Organs you can donate include Internal organs: Kidneys, heart, liver, pancreas, intestines, lungs Skin Bone and bone marrow ...

  1. Matching Organs

    MedlinePlus

    ... Donor Organs With Transplant Candidates When a deceased organ donor is identified, a transplant coordinator from an organ ... transplant candidate, you are registered on the national organ transplant waiting list. A living donor may also be identified and evaluated for living ...

  2. Heterogeneity of newly inserted and preexisting murein in the sacculus of Escherichia coli.

    PubMed Central

    de Pedro, M A; Schwarz, U

    1981-01-01

    In vivo studies of murein biosynthesis show that newly synthesized murein unexpectedly differs in its chemical composition from preexisting murein. New murein is loosely crosslinked with the preexisting sacculus; in a maturation process involving further transpeptidation, the final stage of crosslinkage in murein is achieved. Newly inserted murein initially carries pentapeptide subunits, which are the donor of the secondary transpeptidation reaction. In mutants with defective penicillin-binding protein 4 the secondary transpeptidation step is abolished. Uncoupling of the secondary transpeptidation reaction from crosslink formation during the initial insertion of new murein was also found in a mutant with a defect in lipoprotein biosynthesis. We conclude that the initial transpeptidation of murein and crosslink formation during the maturation of newly inserted murein are catalyzed by two different enzyme systems. PMID:7029548

  3. Macrobenthic diversity in protected, disturbed, and newly formed intertidal wetlands of a subtropical estuary in China.

    PubMed

    Lv, Weiwei; Ma, Chang-an; Huang, Youhui; Yang, Yang; Yu, Ji; Zhang, Mingqing; Zhao, Yunlong

    2014-12-15

    In this study, intertidal macrobenthic diversity in protected, disturbed, and newly formed wetlands of Yangtze estuary was assessed using PRIMER 5.2 based on species diversity and species relatedness. We observed high diversity in nature reserves and low diversity in adjacent disturbed and newly formed wetlands. These diversity data were then integrated with historical data to detect the variation in macrobenthic diversity over the past two decades. The integrated data indicated that the intertidal macrobenthic diversity sharply decreased in heavy reclamation tidal flats whereas markedly increased in non-disturbed nature reserve and newly formed wetland. Benthic health was observed with the departure degree of average taxonomic distinctness (Δ(+)) and variation in taxonomic distinctness (Λ(+)) from the simulated 95% confidence funnel. All the habitats were subjected to different levels of human interference, except Jiuduansha and Beigangbeisha. The degradation of intertidal wetland in Yangtze estuary was mainly attributed to land reclamation, overgrazing, and overfishing. PMID:25319191

  4. Landscape heterogeneity shapes predation in a newly restored predator-prey system

    USGS Publications Warehouse

    Kauffman, M.J.; Varley, N.; Smith, D.W.; Stahler, D.R.; MacNulty, D.R.; Boyce, M.S.

    2007-01-01

    Because some native ungulates have lived without top predators for generations, it has been uncertain whether runaway predation would occur when predators are newly restored to these systems. We show that landscape features and vegetation, which influence predator detection and capture of prey, shape large-scale patterns of predation in a newly restored predator-prey system. We analysed the spatial distribution of wolf (Canis lupus) predation on elk (Cervus elaphus) on the Northern Range of Yellowstone National Park over 10 consecutive winters. The influence of wolf distribution on kill sites diminished over the course of this study, a result that was likely caused by territorial constraints on wolf distribution. In contrast, landscape factors strongly influenced kill sites, creating distinct hunting grounds and prey refugia. Elk in this newly restored predator-prey system should be able to mediate their risk of predation by movement and habitat selection across a heterogeneous risk landscape. ?? 2007 Blackwell Publishing Ltd/CNRS.

  5. HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.

    PubMed

    Sayan, Murat; Sargin, Fatma; Inan, Dilara; Sevgi, Dilek Y; Celikbas, Aysel K; Yasar, Kadriye; Kaptan, Figen; Kutlu, Selda; Fisgin, Nuriye T; Inci, Ayse; Ceran, Nurgul; Karaoglan, Ilkay; Cagatay, Atahan; Celen, Mustafa K; Koruk, Suda T; Ceylan, Bahadir; Yildirmak, Taner; Akalın, Halis; Korten, Volkan; Willke, Ayse

    2016-01-01

    HIV-1 replication is rapid and highly error-prone. Transmission of a drug-resistant HIV-1 strain is possible and occurs within the HIV-1-infected population. In this study, we aimed to determine the prevalence of transmitted drug resistance mutations (TDRMs) in 1,306 newly diagnosed untreated HIV-1-infected patients from 21 cities across six regions of Turkey between 2010 and 2015. TDRMs were identified according to the criteria provided by the World Health Organization's 2009 list of surveillance drug resistance mutations. The HIV-1 TDRM prevalence was 10.1% (133/1,306) in Turkey. Primary drug resistance mutations (K65R, M184V) and thymidine analogue-associated mutations (TAMs) were evaluated together as nucleos(t)ide reverse transcriptase inhibitor (NRTI) mutations. NRTI TDRMs were found in 8.1% (107/1,306) of patients. However, TAMs were divided into three categories and M41L, L210W, and T215Y mutations were found for TAM1 in 97 (7.4%) patients, D67N, K70R, K219E/Q/N/R, T215F, and T215C/D/S mutations were detected for TAM2 in 52 (3.9%) patients, and M41L + K219N and M41L + T215C/D/S mutations were detected for the TAM1 + TAM2 profile in 22 (1.7%) patients, respectively. Nonnucleoside reverse transcriptase inhibitor-associated TDRMs were detected in 3.3% (44/1,306) of patients (L100I, K101E/P, K103N/S, V179F, Y188H/L/M, Y181I/C, and G190A/E/S) and TDRMs to protease inhibitors were detected in 2.3% (30/1,306) of patients (M46L, I50V, I54V, Q58E, L76V, V82A/C/L/T, N83D, I84V, and L90M). In conclusion, long-term and large-scale monitoring of regional levels of HIV-1 TDRMs informs treatment guidelines and provides feedback on the success of HIV-1 prevention and treatment efforts. PMID:26414663

  6. [Variation in indoor air pollutant concentrations with time in a newly constructed private house].

    PubMed

    Minami, Tamae; Matsumoto, Hiroshi; Kondo, Fumio; Yamada, Seiji; Matsumura, Toshiro; Ando, Masanori; Miyazaki, Yutaka

    2002-03-01

    An indoor air quality research project was conducted in a new private house built in January 1997 to investigate time course changes in formaldehyde concentrations during an 11-month period from April 1997 to February 1998. Indoor and outdoor concentrations of volatile organic compounds (VOCs) and nitrogen dioxide were also measured in August 1997 and February 1998. Indoor formaldehyde concentrations were measured 14 times (48 hrs sampling for each measurement) for 28 days in the living room, a bedroom and the kitchen in April '97. The concentrations exceeded the Japanese Government's guideline value of 0.08 ppm in 34 of the 42 (81.0%). Day to day variation in the formaldehyde concentration was found to be substantial, the range being between 0.073 and 0.232 ppm for the bedroom, for example. In June and August '97, values for 20 of 21 measurements exceeded the guideline, the results suggesting that indoor formaldehyde concentrations remain high until 7 months after the completion of construction. There were positive correlations between the formaldehyde concentrations in the living room and the kitchen and personal exposure levels to formaldehyde, the result indicating a direct influence of the home environment. The formaldehyde concentration in the living room also exhibited a positive correlation with the room temperature. Natural ventilation by opening windows was found to be effective for decreasing the concentration of formaldehyde in the indoor air. Indoor VOC concentrations decreased rapidly after the completion of construction except for that of toluene, which was higher than the outdoor concentration even after 7 months. Indoor concentrations of all of the VOCs were, however, found to be almost the same as those outdoor at the 13 month time point. Indoor nitrogen dioxide concentrations measured in the bedroom in winter (February '98) exceeded the Environmental Air Quality Standard in Japan, this result being considered due to use of an oil fan heater

  7. Co-translational Protein Processing, Folding, Targeting, and Membrane Insertion of Newly Synthesized Proteins

    NASA Astrophysics Data System (ADS)

    Boehringer, Daniel; Ban, Nenad

    Newly synthesized proteins leave the ribosome through the nascent polypeptide tunnel. Through the coordinated action of the ribosome associated chaperones, nascent chain processing enzymes, the signal recognition particle, and the protein insertion machinery newly synthesized proteins are brought into their native state and proper cellular localization. The interplay of these factors during ongoing synthesis requires spatial and temporal control of their interactions with the ribosome. We used electron microscopy in combination with crystallography and biochemical methods to study the structure of bacterial ribosomes and nascent chain interacting factors.

  8. A retention strategy for newly graduated nurses: an integrative review of orientation programs.

    PubMed

    Park, Mihyun; Jones, Cheryl B

    2010-01-01

    To address nurse recruitment and retention issues, hospitals have increased the number of newly graduated nurses in their hiring pools and have simultaneously established orientation programs for those nurses. Structured orientation programs facilitate newly graduated nurse transition from novice to advanced beginner. The outcome of these programs is twofold: First, they promote the confidence and competency level of new nurses in providing patient care, and second, they increase nurse retention. This literature review presents the most useful interventions used in the programs that reported positive affects on new nurses. PMID:20683297

  9. Newly Paralyzed

    MedlinePlus

    ... are available to answer your questions. Call toll-free 1-800-539-7309 Mon-Fri, 9am-5pm ... are people living with or impacted by paralysis. Free services and downloads > Paralysis Resource Guide Our free ...

  10. Newly Diagnosed

    MedlinePlus

    ... Video Games Video Sharing Sites Webcasts/ Webinars Widgets Wikis Follow Us on New Media Virtual Office Hours ... is good news: by getting linked to HIV medical care early, starting antiretroviral therapy (ART), adhering to ...

  11. Circulation of Newly-Acquired Materials at the Juniata College Library.

    ERIC Educational Resources Information Center

    Eyman, David H.

    Using circulation data to determine whether materials specifically acquired for the circulation collections of libraries at undergraduate institutions show heavy use, this study examined the first 3 years of shelf life of one year's book acquisitions at a small liberal arts college. Contrary to expectations of a high rate of use for newly acquired…

  12. Superintendents' Perceptions of the Effectiveness of Newly Hired Principals

    ERIC Educational Resources Information Center

    Lehman, Lynn E.; Boyland, Lori G.; Sriver, Shawn K.

    2014-01-01

    This study investigates the frequency of research-based leadership strategies utilized by newly hired school principals in the workplace. Public school superintendents in Indiana were asked to respond to two open-ended research questions. Through the use of content analysis, their comments were coded for the occurrence of effective leadership…

  13. Ethics seminars: the ethical debate on practicing procedures on the newly dead.

    PubMed

    Schmidt, Terri A; Abbott, Jean T; Geiderman, Joel M; Hughes, Jason A; Johnson, Catherine X; McClure, Katie B; McKay, Mary P; Razzak, Junaid A; Salo, David; Schears, Raquel M; Solomon, Robert C

    2004-09-01

    Emergency medicine and its academic teaching programs face an ethical dilemma surrounding the question of practicing procedures on the newly dead. For many years, procedures have been practiced on the newly dead, but few institutions have had policies addressing the practice. This article considers the ethical arguments both for and against practicing procedures on the newly dead without consent, reviews the empirical studies on the subject, and presents the positions of other professional societies, before concluding with the position of the Society for Academic Emergency Medicine (SAEM). SAEM strongly encourages all emergency medicine training programs to develop a policy and make that policy available to the institution, educators, trainees, and the public. The practice should not occur behind closed doors or on an ad hoc basis without clearly articulated guidelines. With improvements in technology, including patient simulation and virtual reality, the need for the practice may decrease, but there is no current evidence that is compelling regarding the best methods of teaching procedural skills. Given the importance of protecting trust in the profession of medicine and the existing evidence that the public would expect that consent be obtained, SAEM recommends that families be asked for consent prior to practicing procedures on the newly dead. PMID:15347547

  14. PRODUCTION OF D-ARABITOL BY A NEWLY ISOLATED ZYGOSACCHAROMYCES ROUXII

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A newly isolated Zygosaccharomyces rouxii NRRL 27,624 produced D-arabitol as the main metabolic product from glucose. In addition, it also produced ethanol and glycerol. The optimal conditions were: temperature 30 deg C, pH 5.0, 350 rpm, and 5% inoculum. The yeast produced 83.4 ± 1.1 g D-arabito...

  15. A new species in the newly recorded genus Trachyusa (Hymenoptera: Braconidae: Alysiinae) from China

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Trachyusa whartoni Yao sp. nov. from Dalian, Liaoning, China is described and illustrated. Trachyusa is a newly recorded genus in China. A key to the species of Trachyusa is provided based on the keys of Belokobylskij (1998), Papp (1967), and van Achterberg and O'Connor (1990). Type specimens of the...

  16. Colonization of a Newly Constructed Commercial Chicken Further Processing Plant with Listeria monocytogenes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study was undertaken to determine potential sources of Listeria monocytogenes in a newly constructed chicken further processing plant and document the eventual colonization of the facility by this pathogen. To ascertain the colonization status of the plant, floor drains were sampled after a pr...

  17. Identifying the Training Needs of Heads of Department in a Newly Established University in Vietnam

    ERIC Educational Resources Information Center

    Nguyen, Thi Lan Huong

    2012-01-01

    Although middle-level academic managers really need training in order to perform their roles adequately in the very changing context of higher education, little formal training is provided, particularly in less developed countries. This paper identifies the training needs of Heads of Department in a newly established university in Vietnam as a…

  18. The newly recognised limb/pelvis-hypoplasia/aplasia syndrome: report of a Bedouin patient and review.

    PubMed Central

    Farag, T I; al-Awadi, S A; Marafie, M J; Bastaki, L; al-Othman, S A; Mohammed, F M; AlSuliman, I S; Murthy, D S

    1993-01-01

    A Bedouin infant born to consanguineous parents and grandparents is reported. She had Müllerian aplasia and the phenotypic features of the limb/pelvis-hypoplasia/aplasia syndrome (MIM 276820). Phenotypic variability of this newly recognised syndrome is briefly discussed. Images PMID:8423610

  19. A Behavioral Investigation of Preference in a Newly Designed New Zealand Playground

    ERIC Educational Resources Information Center

    Bourke, Tina M.; Sargisson, Rebecca J.

    2014-01-01

    Playgrounds with spaces that attract children increase the likelihood children will use them, the authors note, and playgrounds offer an opportunity for children to experience the risks of outdoor play. The authors used natural observation to study the children at play in a newly built New Zealand playground where such an important kind of…

  20. Using Narrative to Make Sense of Transitions: Supporting Newly Arrived Children and Young People

    ERIC Educational Resources Information Center

    Hulusi, Halit; Oland, Louise

    2010-01-01

    Immigration is currently high on the political agenda, yet there is a lack of information regarding the number of children who migrate to the UK and how their needs can be best met. There are many claims in the media that the influx of immigrants from newly endorsed EU countries is becoming a drain on resources, in terms of education and health…

  1. Diabetes education improves depressive state in newly diagnosed patients with type 2 diabetes

    PubMed Central

    Chen, Bin; Zhang, Xiyao; Xu, Xiuping; Lv, Xiaofeng; Yao, Lu; Huang, Xu; Guo, Xueying; Liu, Baozhu; Li, Qiang; Cui, Can

    2013-01-01

    Objectives: The prevalence of depression is relatively high in individuals with diabetes. However, screening and monitoring of depressive state in patients with diabetes is still neglected in developing countries and the treatment of diabetes-related depression is rarely performed in these countries. In this study, our aim was to study the role of diabetes education in the improvement of depressive state in newly diagnosed patients with type 2 diabetes. Methods: The Dutch version of the center for epidemiological studies depression scale (CES-D scale) and the problem areas in diabetes (PAID) questionnaire were used to assess depression and diabetes-specific emotional distress in 1200 newly diagnosed male adult patients with type 2 diabetes before and after a two-week diabetes education by professionally trained nurses. Pearson correlation and regression analysis were used to analyze the factors related to depression in patients with type 2 diabetes. Results: The incidence of depression in newly diagnosed patients with type 2 diabetes was 28%, and the rate of diabetes-specific emotional distress was 65.5%. High education levels, low income were correlated to depression in individuals with diabetes. After two weeks of diabetes education, the incidence of depression and diabetes-specific emotional distress decreased significantly to 20.5% (P < 0.05) and 11% (P < 0.001), respectively. Conclusions: The incidence of depression, especially diabetes-specific emotional distress, was relatively high in newly diagnosed patients with type 2 diabetes. The depression state could be improved by diabetes education. PMID:24353709

  2. Polymorphic SSR markers for Plasmopara obducens (Peronosporaceae), the newly emergent downy mildew pathogen of Impatiens (Balsaminaceae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Premise of the study: Microsatellite markers were developed for Plasmopara obducens, the causal agent of the newly emergent downy mildew disease of Impatiens walleriana. Methods and Results: A 151.2 Mb draft genome assembly was generated from P. obducens using Illumina technology and mined to identi...

  3. The Importance of Networks for Newly Qualified Teachers in Upper Secondary Education

    ERIC Educational Resources Information Center

    Engvik, Gunnar

    2014-01-01

    Background and purpose: The interest in raising the competence of teachers through networks and network activities is increasing. This article is based on the voices of four newly qualified teachers who give us the opportunity to listen to experiences in authentic surroundings. The purpose of this article is to gain better insight into the type of…

  4. Newly Qualifying Teachers' Perspectives of Diversity and Inclusion: "Understanding through Visual Representations"

    ERIC Educational Resources Information Center

    Phillipson, Sivanes; Forlin, Chris

    2011-01-01

    This research explores the use of visual imagery as a strategy for gaining a greater understanding of diversity and inclusion within regular schools as perceived from the perspective of 118 newly qualifying teachers in Hong Kong. Dyads or small groups of teachers participating in a teacher education course were asked to represent their…

  5. Rapid progression to gummatous syphilitic hepatitis and neurosyphilis in a patient with newly-diagnosed HIV.

    PubMed

    Pilozzi-Edmonds, Laura; Kong, Ling Yuan; Szabo, Jason; Birnbaum, Leora M

    2015-11-01

    We review the literature on hepatic involvement in patients with HIV and syphilis co-infection and describe a case of rapid progression to neurosyphilis and presumed gummatous syphilitic hepatitis in a patient newly diagnosed with HIV. To our knowledge, this is the first case of syphilitic hepatitis with gummas described in the HIV population. PMID:25525055

  6. 33 CFR 106.262 - Security measures for newly-hired employees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... accordance with 49 CFR part 1572 by completing the full enrollment process, paying the user fee, and is not... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Security measures for newly-hired... SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES Outer...

  7. 33 CFR 106.262 - Security measures for newly-hired employees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... accordance with 49 CFR part 1572 by completing the full enrollment process, paying the user fee, and is not... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Security measures for newly-hired... SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES Outer...

  8. 10 CFR 1045.18 - Newly generated information in a previously declassified subject area.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Newly generated information in a previously declassified subject area. 1045.18 Section 1045.18 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Identification of Restricted Data and Formerly Restricted Data...

  9. 10 CFR 1045.18 - Newly generated information in a previously declassified subject area.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Newly generated information in a previously declassified subject area. 1045.18 Section 1045.18 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Identification of Restricted Data and Formerly Restricted Data...

  10. 10 CFR 1045.18 - Newly generated information in a previously declassified subject area.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Newly generated information in a previously declassified subject area. 1045.18 Section 1045.18 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Identification of Restricted Data and Formerly Restricted Data...