Astrophysical applications of gravitational microlensing

NASA Astrophysics Data System (ADS)

Mao, Shude

2012-08-01

Since the first discovery of microlensing events nearly two decades ago, gravitational microlensing has accumulated tens of TBytes of data and developed into a powerful astrophysical technique with diverse applications. The review starts with a theoretical overview of the field and then proceeds to discuss the scientific highlights. (1) Microlensing observations toward the Magellanic Clouds rule out the Milky Way halo being dominated by MAssive Compact Halo Objects (MACHOs). This confirms most dark matter is non-baryonic, consistent with other observations. (2) Microlensing has discovered about 20 extrasolar planets (16 published), including the first two Jupiter-Saturn like systems and the only five “cold Neptunes" yet detected. They probe a different part of the parameter space and will likely provide the most stringent test of core accretion theory of planet formation. (3) Microlensing provides a unique way to measure the mass of isolated stars, including brown dwarfs and normal stars. Half a dozen or so stellar mass black hole candidates have also been proposed. (4) High-resolution, target-of-opportunity spectra of highly-magnified dwarf stars provide intriguing “age" determinations which may either hint at enhanced helium enrichment or unusual bulge formation theories. (5) Microlensing also measured limb-darkening profiles for close to ten giant stars, which challenges stellar atmosphere models. (6) Data from surveys also provide strong constraints on the geometry and kinematics of the Milky Way bar (through proper motions); the latter indicates predictions from current models appear to be too anisotropic compared with observations. The future of microlensing is bright given the new capabilities of current surveys and forthcoming new telescope networks from the ground and from space. Some open issues in the field are identified and briefly discussed.

GERLUMPH Data Release 2: 2.5 Billion Simulated Microlensing Light Curves

NASA Astrophysics Data System (ADS)

Vernardos, G.; Fluke, C. J.; Bate, N. F.; Croton, D.; Vohl, D.

2015-04-01

In the upcoming synoptic all-sky survey era of astronomy, thousands of new multiply imaged quasars are expected to be discovered and monitored regularly. Light curves from the images of gravitationally lensed quasars are further affected by superimposed variability due to microlensing. In order to disentangle the microlensing from the intrinsic variability of the light curves, the time delays between the multiple images have to be accurately measured. The resulting microlensing light curves can then be analyzed to reveal information about the background source, such as the size of the quasar accretion disk. In this paper we present the most extensive and coherent collection of simulated microlensing light curves; we have generated \\gt 2.5 billion light curves using the GERLUMPH high resolution microlensing magnification maps. Our simulations can be used to train algorithms to measure lensed quasar time delays, plan future monitoring campaigns, and study light curve properties throughout parameter space. Our data are openly available to the community and are complemented by online eResearch tools, located at http://gerlumph.swin.edu.au.

The Next Generation Transit Survey (NGTS)

NASA Astrophysics Data System (ADS)

Wheatley, Peter J.; West, Richard G.; Goad, Michael R.; Jenkins, James S.; Pollacco, Don L.; Queloz, Didier; Rauer, Heike; Udry, Stéphane; Watson, Christopher A.; Chazelas, Bruno; Eigmüller, Philipp; Lambert, Gregory; Genolet, Ludovic; McCormac, James; Walker, Simon; Armstrong, David J.; Bayliss, Daniel; Bento, Joao; Bouchy, François; Burleigh, Matthew R.; Cabrera, Juan; Casewell, Sarah L.; Chaushev, Alexander; Chote, Paul; Csizmadia, Szilárd; Erikson, Anders; Faedi, Francesca; Foxell, Emma; Gänsicke, Boris T.; Gillen, Edward; Grange, Andrew; Günther, Maximilian N.; Hodgkin, Simon T.; Jackman, James; Jordán, Andrés; Louden, Tom; Metrailler, Lionel; Moyano, Maximiliano; Nielsen, Louise D.; Osborn, Hugh P.; Poppenhaeger, Katja; Raddi, Roberto; Raynard, Liam; Smith, Alexis M. S.; Soto, Maritza; Titz-Weider, Ruth

2018-04-01

We describe the Next Generation Transit Survey (NGTS), which is a ground-based project searching for transiting exoplanets orbiting bright stars. NGTS builds on the legacy of previous surveys, most notably WASP, and is designed to achieve higher photometric precision and hence find smaller planets than have previously been detected from the ground. It also operates in red light, maximizing sensitivity to late K and early M dwarf stars. The survey specifications call for photometric precision of 0.1 per cent in red light over an instantaneous field of view of 100 deg2, enabling the detection of Neptune-sized exoplanets around Sun-like stars and super-Earths around M dwarfs. The survey is carried out with a purpose-built facility at Cerro Paranal, Chile, which is the premier site of the European Southern Observatory (ESO). An array of twelve 20 cm f/2.8 telescopes fitted with back-illuminated deep-depletion CCD cameras is used to survey fields intensively at intermediate Galactic latitudes. The instrument is also ideally suited to ground-based photometric follow-up of exoplanet candidates from space telescopes such as TESS, Gaia and PLATO. We present observations that combine precise autoguiding and the superb observing conditions at Paranal to provide routine photometric precision of 0.1 per cent in 1 h for stars with I-band magnitudes brighter than 13. We describe the instrument and data analysis methods as well as the status of the survey, which achieved first light in 2015 and began full-survey operations in 2016. NGTS data will be made publicly available through the ESO archive.

Challenges in Timeseries Analysis from Microlensing

NASA Astrophysics Data System (ADS)

Street, R. A.

2017-06-01

Despite a flood of discoveries over the last ~ 20 years, our knowledge of the exoplanet population is incomplete owing to a gap between the sensitivities of different detection techniques. However, a census of exoplanets at all separations from their host stars is essential to fully understand planet formation mechanisms. Microlensing offers an effective way to bridge the gap around 1-10 AU and is therefore one of the major science goals of the Wide Field Infrared Survey Telescope (WFIRST) mission. WFIRST's survey of the Galactic Bulge is expected to discover ~ 20,000 microlensing events, including ~ 3000 planets, which represents a substantial data analysis challenge with the modeling software currently available. This paper highlights areas where further work is needed. The community is encouraged to join new software development efforts aimed at making the modeling of microlensing events both more accessible and rigorous.

Accurately Mapping M31's Microlensing Population

NASA Astrophysics Data System (ADS)

Crotts, Arlin

2004-07-01

We propose to augment an existing microlensing survey of M31 with source identifications provided by a modest amount of ACS {and WFPC2 parallel} observations to yield an accurate measurement of the masses responsible for microlensing in M31, and presumably much of its dark matter. The main benefit of these data is the determination of the physical {or "einstein"} timescale of each microlensing event, rather than an effective {"FWHM"} timescale, allowing masses to be determined more than twice as accurately as without HST data. The einstein timescale is the ratio of the lensing cross-sectional radius and relative velocities. Velocities are known from kinematics, and the cross-section is directly proportional to the {unknown} lensing mass. We cannot easily measure these quantities without knowing the amplification, hence the baseline magnitude, which requires the resolution of HST to find the source star. This makes a crucial difference because M31 lens m ass determinations can be more accurate than those towards the Magellanic Clouds through our Galaxy's halo {for the same number of microlensing events} due to the better constrained geometry in the M31 microlensing situation. Furthermore, our larger survey, just completed, should yield at least 100 M31 microlensing events, more than any Magellanic survey. A small amount of ACS+WFPC2 imaging will deliver the potential of this large database {about 350 nights}. For the whole survey {and a delta-function mass distribution} the mass error should approach only about 15%, or about 6% error in slope for a power-law distribution. These results will better allow us to pinpoint the lens halo fraction, and the shape of the halo lens spatial distribution, and allow generalization/comparison of the nature of halo dark matter in spiral galaxies. In addition, we will be able to establish the baseline magnitude for about 50, 000 variable stars, as well as measure an unprecedentedly deta iled color-magnitude diagram and luminosity

Polarimetry Microlensing of Close-in Planetary Systems

NASA Astrophysics Data System (ADS)

Sajadian, Sedighe; Hundertmark, Markus

2017-04-01

A close-in giant planetary (CGP) system has a net polarization signal whose value varies depending on the orbital phase of the planet. This polarization signal is either caused by the stellar occultation or by reflected starlight from the surface of the orbiting planet. When the CGP system is located in the Galactic bulge, its polarization signal becomes too weak to be measured directly. One method for detecting and characterizing these weak polarization signatures due to distant CGP systems is gravitational microlensing. In this work, we focus on potential polarimetric observations of highly magnified microlensing events of CGP systems. When the lens is passing directly in front of the source star with its planetary companion, the polarimetric signature caused by the transiting planet is magnified. As a result, some distinct features in the polarimetry and light curves are produced. In the same way, microlensing amplifies the reflection-induced polarization signal. While the planet-induced perturbations are magnified whenever these polarimetric or photometric deviations vanish for a moment, the corresponding magnification factor of the polarization component(s) is related to the planet itself. Finding these exact times in the planet-induced perturbations helps us to characterize the planet. In order to evaluate the observability of such systems through polarimetric or photometric observations of high-magnification microlensing events, we simulate these events by considering confirmed CGP systems as their source stars and conclude that the efficiency for detecting the planet-induced signal with the state-of-the-art polarimetric instrument (FORS2/VLT) is less than 0.1%. Consequently, these planet-induced polarimetry perturbations can likely be detected under favorable conditions by the high-resolution and short-cadence polarimeters of the next generation.

Deep Generative Models of Galaxy Images for the Calibration of the Next Generation of Weak Lensing Surveys

NASA Astrophysics Data System (ADS)

Lanusse, Francois; Ravanbakhsh, Siamak; Mandelbaum, Rachel; Schneider, Jeff; Poczos, Barnabas

2017-01-01

Weak gravitational lensing has long been identified as one of the most powerful probes to investigate the nature of dark energy. As such, weak lensing is at the heart of the next generation of cosmological surveys such as LSST, Euclid or WFIRST.One particularly crititcal source of systematic errors in these surveys comes from the shape measurement algorithms tasked with estimating galaxy shapes. GREAT3, the last community challenge to assess the quality of state-of-the-art shape measurement algorithms has in particular demonstrated that all current methods are biased to various degrees and, more importantly, that these biases depend on the details of the galaxy morphologies. These biases can be measured and calibrated by generating mock observations where a known lensing signal has been introduced and comparing the resulting measurements to the ground-truth. Producing these mock observations however requires input galaxy images of higher resolution and S/N than the simulated survey, which typically implies acquiring extremely expensive space-based observations.The goal of this work is to train a deep generative model on already available Hubble Space Telescope data which can then be used to sample new galaxy images conditioned on parameters such as magnitude, size or redshift and exhibiting complex morphologies. Such model can allow us to inexpensively produce large set of realistic realistic images for calibration purposes.We implement a conditional generative model based on state-of-the-art deep learning methods and fit it to deep galaxy images from the COSMOS survey. The quality of the model is assessed by computing an extensive set of galaxy morphology statistics on the generated images. Beyond simple second moment statistics such as size and ellipticity, we apply more complex statistics specifically designed to be sensitive to disturbed galaxy morphologies. We find excellent agreement between the morphologies of real and model generated galaxies.Our results

pyLIMA : an open source microlensing software

NASA Astrophysics Data System (ADS)

Bachelet, Etienne

2017-01-01

Planetary microlensing is a unique tool to detect cold planets around low-mass stars which is approaching a watershed in discoveries as near-future missions incorporate dedicated surveys. NASA and ESA have decided to complement WFIRST-AFTA and Euclid with microlensing programs to enrich our statistics about this planetary population. Of the nany challenges in- herent in these missions, the data analysis is of primary importance, yet is often perceived as time consuming, complex and daunting barrier to participation in the field. We present the first open source modeling software to conduct a microlensing analysis. This software is written in Python and use as much as possible existing packages.

Spitzer Parallax Observations of Long Duration Gaia Microlensing Events

NASA Astrophysics Data System (ADS)

Carey, Sean; Calchi-Novati, Sebastiano; Wyrzykowski, Lukasz; Kruszynska, Katarzyna; Gromadzki, Mariusz; Rybicki, Krzysztof

2018-05-01

We proposed to observe of order ten long duration (>100 day) microlensing events identified in Gaia survey data with the Spitzer Space Telescope. The long duration events are likely due to massive lenses, hence they could be isolated black holes. These observations could make defintive mass measurements for the first time of isolated stellar remanant black holes in our Galaxy. The Spitzer data provide a key component to making an umabiguous mass measurement by providing the microlensing parallax (as has been done for >500 event by Spitzer so far). The Gaia data is used for the detection of the events and measurement of the astrometric motion caused by the microlensing event. From the astrometric microlensing signature, the Einstein radius of the lens can be measured and combined with the microlensing parallax yields the lens mass and distance.

Probing primordial features with next-generation photometric and radio surveys

NASA Astrophysics Data System (ADS)

Ballardini, M.; Finelli, F.; Maartens, R.; Moscardini, L.

2018-04-01

We investigate the possibility of using future photometric and radio surveys to constrain the power spectrum of primordial fluctuations that is predicted by inflationary models with a violation of the slow-roll phase. We forecast constraints with a Fisher analysis on the amplitude of the parametrized features on ultra-large scales, in order to assess whether these could be distinguishable over the cosmic variance. We find that the next generation of photometric and radio surveys has the potential to test these models at a sensitivity better than current CMB experiments and that the synergy between galaxy and CMB observations is able to constrain models with many extra parameters. In particular, an SKA continuum survey with a huge sky coverage and a flux threshold of a few μJy could confirm the presence of a new phase in the early Universe at more than 3σ.

RoboTAP: Target priorities for robotic microlensing observations

NASA Astrophysics Data System (ADS)

Hundertmark, M.; Street, R. A.; Tsapras, Y.; Bachelet, E.; Dominik, M.; Horne, K.; Bozza, V.; Bramich, D. M.; Cassan, A.; D'Ago, G.; Figuera Jaimes, R.; Kains, N.; Ranc, C.; Schmidt, R. W.; Snodgrass, C.; Wambsganss, J.; Steele, I. A.; Mao, S.; Ment, K.; Menzies, J.; Li, Z.; Cross, S.; Maoz, D.; Shvartzvald, Y.

2018-01-01

Context. The ability to automatically select scientifically-important transient events from an alert stream of many such events, and to conduct follow-up observations in response, will become increasingly important in astronomy. With wide-angle time domain surveys pushing to fainter limiting magnitudes, the capability to follow-up on transient alerts far exceeds our follow-up telescope resources, and effective target prioritization becomes essential. The RoboNet-II microlensing program is a pathfinder project, which has developed an automated target selection process (RoboTAP) for gravitational microlensing events, which are observed in real time using the Las Cumbres Observatory telescope network. Aims: Follow-up telescopes typically have a much smaller field of view compared to surveys, therefore the most promising microlensing events must be automatically selected at any given time from an annual sample exceeding 2000 events. The main challenge is to select between events with a high planet detection sensitivity, with the aim of detecting many planets and characterizing planetary anomalies. Methods: Our target selection algorithm is a hybrid system based on estimates of the planet detection zones around a microlens. It follows automatic anomaly alerts and respects the expected survey coverage of specific events. Results: We introduce the RoboTAP algorithm, whose purpose is to select and prioritize microlensing events with high sensitivity to planetary companions. In this work, we determine the planet sensitivity of the RoboNet follow-up program and provide a working example of how a broker can be designed for a real-life transient science program conducting follow-up observations in response to alerts; we explore the issues that will confront similar programs being developed for the Large Synoptic Survey Telescope (LSST) and other time domain surveys.

Adventures in the microlensing cloud: Large datasets, eResearch tools, and GPUs

NASA Astrophysics Data System (ADS)

Vernardos, G.; Fluke, C. J.

2014-10-01

As astronomy enters the petascale data era, astronomers are faced with new challenges relating to storage, access and management of data. A shift from the traditional approach of combining data and analysis at the desktop to the use of remote services, pushing the computation to the data, is now underway. In the field of cosmological gravitational microlensing, future synoptic all-sky surveys are expected to bring the number of multiply imaged quasars from the few tens that are currently known to a few thousands. This inflow of observational data, together with computationally demanding theoretical modeling via the production of microlensing magnification maps, requires a new approach. We present our technical solutions to supporting the GPU-Enabled, High Resolution cosmological MicroLensing parameter survey (GERLUMPH). This extensive dataset for cosmological microlensing modeling comprises over 70 000 individual magnification maps and ˜106 related results. We describe our approaches to hosting, organizing, and serving ˜ 30 TB of data and metadata products. We present a set of online analysis tools developed with PHP, JavaScript and WebGL to support access and analysis of GELRUMPH data in a Web browser. We discuss our use of graphics processing units (GPUs) to accelerate data production, and we release the core of the GPU-D direct inverse ray-shooting code (Thompson et al., 2010, 2014) used to generate the magnification maps. All of the GERLUMPH data and tools are available online from http://gerlumph.swin.edu.au. This project made use of gSTAR, the GPU Supercomputer for Theoretical Astrophysical Research.

WFIRST Microlensing Exoplanet Characterization with HST Follow up

NASA Astrophysics Data System (ADS)

Bhattacharya, Aparna; David Bennett, Jay Anderson, J.P. Beaulieu.

2018-01-01

More than 50 planets are discovered with the different ground based telescopes available for microlensing. But the analysis of ground based data fails to provide a complete solution. To fulfill that gap, space based telescopes, like Hubble space telescope and Spitzer are used. My research work focuses on extracting the planet mass, host star mass, their separation and their distance in physical units from HST Follow-up observations. I will present the challenges faced in developing this method.This is the primary method to be used for NASA's top priority project (according to 2010 decadal survey) Wide Field InfraRed Survey Telescope (WFIRST) Exoplanet microlensing space observatory, to be launched in 2025. The unique ability of microlensing is that with WFIRST it can detect sub-earth- mass planets beyond the reach of Kepler at separation 1 AU to infinity. This will provide us the necessary statistics to study the formation and evolution of planetary systems. This will also provide us with necessary initial conditions to model the formation of planets and the habitable zones around M dwarf stars.

A Spectroscopic and Photometric Study of Gravitational Microlensing Events

NASA Astrophysics Data System (ADS)

Kane, Stephen R.

2000-08-01

Gravitational microlensing has generated a great deal of scientific interest over recent years. This has been largely due to the realization of its wide-reaching applications, such as the search for dark matter, the detection of planets, and the study of Galactic structure. A significant observational advance has been that most microlensing events can be identified in real-time while the source is still being lensed. More than 400 microlensing events have now been detected towards the Galactic bulge and Magellanic Clouds by the microlensing survey teams EROS, MACHO, OGLE, DUO, and MOA. The real-time detection of these events allows detailed follow-up observations with much denser sampling, both photometrically and spectroscopically. The research undertaken in this project on photometric studies of gravitational microlensing events has been performed as a member of the PLANET (Probing Lensing Anomalies NETwork) collaboration. This is a worldwide collaboration formed in the early part of 1995 to study microlensing anomalies - departures from an achromatic point source, point lens light curve - through rapidly-sampled, multi-band, photometry. PLANET has demonstrated that it can achieve 1% photometry under ideal circumstances, making PLANET observations sensitive to detection of Earth-mass planets which require characterization of 1%--2% deviations from a standard microlensing light curve. The photometric work in this project involved over 5 months using the 1.0 m telescope at Canopus Observatory in Australia, and 3 separate observing runs using the 0.9 m telescope at the Cerro Tololo Inter-American Observatory (CTIO) in Chile. Methods were developed to reduce the vast amount of photometric data using the image analysis software MIDAS and the photometry package DoPHOT. Modelling routines were then written to analyse a selection of the resulting light curves in order to detect any deviation from an achromatic point source - point lens light curve. The photometric

The influence of microlensing on spectral line shapes generated by a relativistic accretion disc

NASA Astrophysics Data System (ADS)

Popović, L. Č; Mediavilla, E. G.; Muñoz, J. A.

2001-10-01

We study the influence of gravitational microlensing on the spectral line profiles originating from a relativistic accretion disc. Using the Chen & Halpern model for the disc, we show the noticeable changes that microlensing can induce in the line shape when the Einstein radius associated with the microlens is of a size comparable to that of the accretion disc. Of special interest is the relative enhancement between the blue and red peaks of the line when an off-center microlens affects the approaching and receding parts of the accretion disc asymmetrically. In an AGN formed by a super-massive binary in which the accretion disc is located around one of the super-massive companions (the primary), we discuss the possibility of microlensing by the secondary. In this case the ratio between the blue and red peaks of the line profile would depend on the orbital phase. We have also considered the more standard configuration of microlensing by a star-sized object in an intervening galaxy and find that microlensing may also be detected in the broad emission lines of multiply imaged QSOs. The changes observed in the line profile of Arp 102 B are taken as a reference for exploring both scenarios.

pyLIMA: An Open-source Package for Microlensing Modeling. I. Presentation of the Software and Analysis of Single-lens Models

NASA Astrophysics Data System (ADS)

Bachelet, E.; Norbury, M.; Bozza, V.; Street, R.

2017-11-01

Microlensing is a unique tool, capable of detecting the “cold” planets between ˜1 and 10 au from their host stars and even unbound “free-floating” planets. This regime has been poorly sampled to date owing to the limitations of alternative planet-finding methods, but a watershed in discoveries is anticipated in the near future thanks to the planned microlensing surveys of WFIRST-AFTA and Euclid's Extended Mission. Of the many challenges inherent in these missions, the modeling of microlensing events will be of primary importance, yet it is often time-consuming, complex, and perceived as a daunting barrier to participation in the field. The large scale of future survey data products will require thorough but efficient modeling software, but, unlike other areas of exoplanet research, microlensing currently lacks a publicly available, well-documented package to conduct this type of analysis. We present version 1.0 of the python Lightcurve Identification and Microlensing Analysis (pyLIMA). This software is written in Python and uses existing packages as much as possible to make it widely accessible. In this paper, we describe the overall architecture of the software and the core modules for modeling single-lens events. To verify the performance of this software, we use it to model both real data sets from events published in the literature and generated test data produced using pyLIMA's simulation module. The results demonstrate that pyLIMA is an efficient tool for microlensing modeling. We will expand pyLIMA to consider more complex phenomena in the following papers.

Brainstorming about next-generation computer-based documentation: an AMIA clinical working group survey.

PubMed

Johnson, Kevin B; Ravich, William J; Cowan, John A

2004-09-01

Computer-based software to record histories, physical exams, and progress or procedure notes, known as computer-based documentation (CBD) software, has been touted as an important addition to the electronic health record. The functionality of CBD systems has remained static over the past 30 years, which may have contributed to the limited adoption of these tools. Early users of this technology, who have tried multiple products, may have insight into important features to be considered in next-generation CBD systems. We conducted a cross-sectional, observational study of the clinical working group membership of the American Medical Informatics Association (AMIA) to generate a set of features that might improve adoption of next-generation systems. The study was conducted online over a 4-month period; 57% of the working group members completed the survey. As anticipated, CBD tool use was higher (53%) in this population than in the US physician offices. The most common methods of data entry employed keyboard and mouse, with agreement that these modalities worked well. Many respondents had experience with pre-printed data collection forms before interacting with a CBD system. Respondents noted that CBD improved their ability to document large amounts of information, allowed timely sharing of information, enhanced patient care, and enhanced medical information with other clinicians (all P < 0.001). Respondents also noted some important but absent features in CBD, including the ability to add images, get help, and generate billing information. The latest generation of CBD systems is being used successfully by early adopters, who find that these tools confer many advantages over the approaches to documentation that they replaced. These users provide insights that may improve successive generations of CBD tools. Additional surveys of CBD non-users and failed adopters will be necessary to provide other useful insights that can address barriers to the adoption of CBD by less

GRAVITATIONAL MICROLENSING EVENTS AS A TARGET FOR THE SETI PROJECT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rahvar, Sohrab, E-mail: rahvar@sharif.edu

2016-09-01

The detection of signals from a possible extrasolar technological civilization is one of the most challenging efforts of science. In this work, we propose using natural telescopes made of single or binary gravitational lensing systems to magnify leakage of electromagnetic signals from a remote planet that harbors Extraterrestrial Intelligent (ETI) technology. Currently, gravitational microlensing surveys are monitoring a large area of the Galactic bulge to search for microlensing events, finding more than 2000 events per year. These lenses are capable of playing the role of natural telescopes, and, in some instances, they can magnify radio band signals from planets orbitingmore » around the source stars in gravitational microlensing systems. Assuming that the frequency of electromagnetic waves used for telecommunication in ETIs is similar to ours, we propose follow-up observation of microlensing events with radio telescopes such as the Square Kilometre Array (SKA), the Low Frequency Demonstrators, and the Mileura Wide-Field Array. Amplifying signals from the leakage of broadcasting by an Earth-like civilization will allow us to detect them as far as the center of the Milky Way galaxy. Our analysis shows that in binary microlensing systems, the probability of amplification of signals from ETIs is more than that in single microlensing events. Finally, we propose the use of the target of opportunity mode for follow-up observations of binary microlensing events with SKA as a new observational program for searching ETIs. Using optimistic values for the factors of the Drake equation provides detection of about one event per year.« less

Gravitational Microlensing Events as a Target for the SETI project

NASA Astrophysics Data System (ADS)

Rahvar, Sohrab

2016-09-01

The detection of signals from a possible extrasolar technological civilization is one of the most challenging efforts of science. In this work, we propose using natural telescopes made of single or binary gravitational lensing systems to magnify leakage of electromagnetic signals from a remote planet that harbors Extraterrestrial Intelligent (ETI) technology. Currently, gravitational microlensing surveys are monitoring a large area of the Galactic bulge to search for microlensing events, finding more than 2000 events per year. These lenses are capable of playing the role of natural telescopes, and, in some instances, they can magnify radio band signals from planets orbiting around the source stars in gravitational microlensing systems. Assuming that the frequency of electromagnetic waves used for telecommunication in ETIs is similar to ours, we propose follow-up observation of microlensing events with radio telescopes such as the Square Kilometre Array (SKA), the Low Frequency Demonstrators, and the Mileura Wide-Field Array. Amplifying signals from the leakage of broadcasting by an Earth-like civilization will allow us to detect them as far as the center of the Milky Way galaxy. Our analysis shows that in binary microlensing systems, the probability of amplification of signals from ETIs is more than that in single microlensing events. Finally, we propose the use of the target of opportunity mode for follow-up observations of binary microlensing events with SKA as a new observational program for searching ETIs. Using optimistic values for the factors of the Drake equation provides detection of about one event per year.

OGLE-2016-BLG-0168 Binary Microlensing Event: Prediction and Confirmation of the Microlens Parallax Effect from Space-based Observations

NASA Astrophysics Data System (ADS)

Shin, I.-G.; Udalski, A.; Yee, J. C.; Calchi Novati, S.; Han, C.; Skowron, J.; Mróz, P.; Soszyński, I.; Poleski, R.; Szymański, M. K.; Kozłowski, S.; Pietrukowicz, P.; Ulaczyk, K.; Pawlak, M.; OGLE Collaboration; Albrow, M. D.; Gould, A.; Chung, S.-J.; Hwang, K.-H.; Jung, Y. K.; Ryu, Y.-H.; Zhu, W.; Cha, S.-M.; Kim, D.-J.; Kim, H.-W.; Kim, S.-L.; Lee, C.-U.; Lee, Y.; Park, B.-G.; Pogge, R. W.; KMTNet Group; Beichman, C.; Bryden, G.; Carey, S.; Gaudi, B. S.; Henderson, C. B.; Shvartzvald, Y.; Spitzer Team

2017-11-01

The microlens parallax is a crucial observable for conclusively identifying the nature of lens systems in microlensing events containing or composed of faint (even dark) astronomical objects such as planets, neutron stars, brown dwarfs, and black holes. With the commencement of a new era of microlensing in collaboration with space-based observations, the microlens parallax can be routinely measured. In addition, space-based observations can provide opportunities to verify the microlens parallax measured from ground-only observations and to find a unique solution to the lensing light-curve analysis. Furthermore, since most space-based observations cannot cover the full light curves of lensing events, it is also necessary to verify the reliability of the information extracted from fragmentary space-based light curves. We conduct a test based on the microlensing event OGLE-2016-BLG-0168, created by a binary lens system consisting of almost equal mass M-dwarf stars, to demonstrate that it is possible to verify the microlens parallax and to resolve degeneracies using the space-based light curve even though the observations are fragmentary. Since space-based observatories will frequently produce fragmentary light curves due to their short observing windows, the methodology of this test will be useful for next-generation microlensing experiments that combine space-based and ground-based collaboration.

REVIEWS OF TOPICAL PROBLEMS: Gravitational microlensing

NASA Astrophysics Data System (ADS)

Zakharov, Aleksandr F.; Sazhin, Mikhail V.

1998-10-01

The foundations of standard microlensing theory are discussed as applied to stars in the Galactic bulge, Magellanic Clouds or other nearby galaxies and gravitational microlenses assumed to lie in-between these stars and the terrestrial observer. In contrast to the review article by Gurevich et al. [48], microlensing by compact objects is mainly considered. Criteria for the identification of microlensing events are discussed as also are microlensing events not satisfying these criteria, such as non-symmetrical light curves and chromatic and polarization effects. The Large Magellanic Cloud (LMC) and Galactic bulge microlensing data of the MACHO group are discussed in detail and also the LMC data of EROS and the Galactic bulge data of OGLE are presented. A detailed comparison of theoretical predictions and observations is given.

Machine learning and next-generation asteroid surveys

NASA Astrophysics Data System (ADS)

Nugent, Carrie R.; Dailey, John; Cutri, Roc M.; Masci, Frank J.; Mainzer, Amy K.

2017-10-01

Next-generation surveys such as NEOCam (Mainzer et al., 2016) will sift through tens of millions of point source detections daily to detect and discover asteroids. This requires new, more efficient techniques to distinguish between solar system objects, background stars and galaxies, and artifacts such as cosmic rays, scattered light and diffraction spikes.Supervised machine learning is a set of algorithms that allows computers to classify data on a training set, and then apply that classification to make predictions on new datasets. It has been employed by a broad range of fields, including computer vision, medical diagnoses, economics, and natural language processing. It has also been applied to astronomical datasets, including transient identification in the Palomar Transient Factory pipeline (Masci et al., 2016), and in the Pan-STARRS1 difference imaging (D. E. Wright et al., 2015).As part of the NEOCam extended phase A work we apply machine learning techniques to the problem of asteroid detection. Asteroid detection is an ideal application of supervised learning, as there is a wealth of metrics associated with each extracted source, and suitable training sets are easily created. Using the vetted NEOWISE dataset (E. L. Wright et al., 2010, Mainzer et al., 2011) as a proof-of-concept of this technique, we applied the python package sklearn. We report on reliability, feature set selection, and the suitability of various algorithms.

Campaign 9 of the K2 Mission: Observational Parameters, Scientific Drivers, and Community Involvement for a Simultaneous Space- and Ground-based Microlensing Survey

NASA Technical Reports Server (NTRS)

Henderson, Calen B.; Poleski, Radoslaw; Penny, Matthew; Street, Rachel A.; Bennett, David P.; Hogg, David W.; Gaudi, B. Scott; Zhu, W.; Barclay, T.; Barentsen, G.;

A Window Into Clinical Next-Generation Sequencing-Based Oncology Testing Practices.

PubMed

Nagarajan, Rakesh; Bartley, Angela N; Bridge, Julia A; Jennings, Lawrence J; Kamel-Reid, Suzanne; Kim, Annette; Lazar, Alexander J; Lindeman, Neal I; Moncur, Joel; Rai, Alex J; Routbort, Mark J; Vasalos, Patricia; Merker, Jason D

2017-12-01

- Detection of acquired variants in cancer is a paradigm of precision medicine, yet little has been reported about clinical laboratory practices across a broad range of laboratories. - To use College of American Pathologists proficiency testing survey results to report on the results from surveys on next-generation sequencing-based oncology testing practices. - College of American Pathologists proficiency testing survey results from more than 250 laboratories currently performing molecular oncology testing were used to determine laboratory trends in next-generation sequencing-based oncology testing. - These presented data provide key information about the number of laboratories that currently offer or are planning to offer next-generation sequencing-based oncology testing. Furthermore, we present data from 60 laboratories performing next-generation sequencing-based oncology testing regarding specimen requirements and assay characteristics. The findings indicate that most laboratories are performing tumor-only targeted sequencing to detect single-nucleotide variants and small insertions and deletions, using desktop sequencers and predesigned commercial kits. Despite these trends, a diversity of approaches to testing exists. - This information should be useful to further inform a variety of topics, including national discussions involving clinical laboratory quality systems, regulation and oversight of next-generation sequencing-based oncology testing, and precision oncology efforts in a data-driven manner.

BINARY ASTROMETRIC MICROLENSING WITH GAIA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sajadian, Sedighe, E-mail: sajadian@ipm.ir; Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran

2015-04-15

We investigate whether or not Gaia can specify the binary fractions of massive stellar populations in the Galactic disk through astrometric microlensing. Furthermore, we study whether or not some information about their mass distributions can be inferred via this method. In this regard, we simulate the binary astrometric microlensing events due to massive stellar populations according to the Gaia observing strategy by considering (i) stellar-mass black holes, (ii) neutron stars, (iii) white dwarfs, and (iv) main-sequence stars as microlenses. The Gaia efficiency for detecting the binary signatures in binary astrometric microlensing events is ∼10%–20%. By calculating the optical depth duemore » to the mentioned stellar populations, the numbers of the binary astrometric microlensing events being observed with Gaia with detectable binary signatures, for the binary fraction of about 0.1, are estimated to be 6, 11, 77, and 1316, respectively. Consequently, Gaia can potentially specify the binary fractions of these massive stellar populations. However, the binary fraction of black holes measured with this method has a large uncertainty owing to a low number of the estimated events. Knowing the binary fractions in massive stellar populations helps with studying the gravitational waves. Moreover, we investigate the number of massive microlenses for which Gaia specifies masses through astrometric microlensing of single lenses toward the Galactic bulge. The resulting efficiencies of measuring the mass of mentioned populations are 9.8%, 2.9%, 1.2%, and 0.8%, respectively. The numbers of their astrometric microlensing events being observed in the Gaia era in which the lens mass can be inferred with the relative error less than 0.5 toward the Galactic bulge are estimated as 45, 34, 76, and 786, respectively. Hence, Gaia potentially gives us some information about the mass distribution of these massive stellar populations.« less

OGLE-2016-BLG-0168 Binary Microlensing Event: Prediction and Confirmation of the Microlens Parallax Effect from Space-based Observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shin, I.-G.; Yee, J. C.; Jung, Y. K.

The microlens parallax is a crucial observable for conclusively identifying the nature of lens systems in microlensing events containing or composed of faint (even dark) astronomical objects such as planets, neutron stars, brown dwarfs, and black holes. With the commencement of a new era of microlensing in collaboration with space-based observations, the microlens parallax can be routinely measured. In addition, space-based observations can provide opportunities to verify the microlens parallax measured from ground-only observations and to find a unique solution to the lensing light-curve analysis. Furthermore, since most space-based observations cannot cover the full light curves of lensing events, itmore » is also necessary to verify the reliability of the information extracted from fragmentary space-based light curves. We conduct a test based on the microlensing event OGLE-2016-BLG-0168, created by a binary lens system consisting of almost equal mass M-dwarf stars, to demonstrate that it is possible to verify the microlens parallax and to resolve degeneracies using the space-based light curve even though the observations are fragmentary. Since space-based observatories will frequently produce fragmentary light curves due to their short observing windows, the methodology of this test will be useful for next-generation microlensing experiments that combine space-based and ground-based collaboration.« less

OGLE 2003-BLG-235/MOA 2003-BLG-53: A Planetary Microlensing Event

NASA Astrophysics Data System (ADS)

Bond, I. A.; Udalski, A.; Jaroszyński, M.; Rattenbury, N. J.; Paczyński, B.; Soszyński, I.; Wyrzykowski, L.; Szymański, M. K.; Kubiak, M.; Szewczyk, O.; Żebruń, K.; Pietrzyński, G.; Abe, F.; Bennett, D. P.; Eguchi, S.; Furuta, Y.; Hearnshaw, J. B.; Kamiya, K.; Kilmartin, P. M.; Kurata, Y.; Masuda, K.; Matsubara, Y.; Muraki, Y.; Noda, S.; Okajima, K.; Sako, T.; Sekiguchi, T.; Sullivan, D. J.; Sumi, T.; Tristram, P. J.; Yanagisawa, T.; Yock, P. C. M.; OGLE Collaboration

2004-05-01

We present observations of the unusual microlensing event OGLE 2003-BLG-235/MOA 2003-BLG-53. In this event, a short-duration (~7 days) low-amplitude deviation in the light curve due to a single-lens profile was observed in both the MOA (Microlensing Observations in Astrophysics) and OGLE (Optical Gravitational Lensing Experiment) survey observations. We find that the observed features of the light curve can only be reproduced using a binary microlensing model with an extreme (planetary) mass ratio of 0.0039+11-07 for the lensing system. If the lens system comprises a main-sequence primary, we infer that the secondary is a planet of about 1.5 Jupiter masses with an orbital radius of ~3 AU.

Modeling Spectral Variations of Dusty Circumstellar Envelopes During Microlensing Events

NASA Astrophysics Data System (ADS)

Bunker, Christina; Ignace, R.; Bjorkman, J. E.

2007-12-01

Microlensing surveys have proven to be tremendously fruitful in providing valuable data products for many fields of astrophysics, from eclipse lightcurves for substellar candidates to limb darkening in stellar atmospheres. We report on a program of modeling observables from microlensing of circumstellar envelopes, particularly those of red giant stars that are the most likely to show finite source effects. Recent modeling results for the time dependent spectral energy distributions from microlensing of dusty winds are presented. In effect, wavelength-dependent continuum variations that occur as the lens-star separation changes can provide information about the emissivity distribution of dust in the wind. This project was funded by a partnership between the National Science Foundation (NSF AST-0552798), Research Experiences for Undergraduates (REU), and the Department of Defense (DoD) ASSURE (Awards to Stimulate and Support Undergraduate Research Experiences) programs.

Primordial black hole detection through diffractive microlensing

NASA Astrophysics Data System (ADS)

Naderi, T.; Mehrabi, A.; Rahvar, S.

2018-05-01

Recent observations of gravitational waves motivate investigations for the existence of primordial black holes (PBHs). We propose the observation of gravitational microlensing of distant quasars for the range of infrared to the submillimeter wavelengths by sublunar PBHs as lenses. The advantage of observations in the longer wavelengths, comparable to the Schwarzschild radius of the lens (i.e., Rsch≃λ ) is the detection of the wave optics features of the gravitational microlensing. The observation of diffraction pattern in the microlensing light curve of a quasar can break the degeneracy between the lens parameters and determine directly the lens mass as well as the distance of the lens from the observer. We estimate the wave optics optical-depth, also calculate the rate of ˜0.1 to ˜0.3 event per year per a quasar, assuming that hundred percent of dark matter is made of sublunar PBHs. Also, we propose a long-term survey of quasars with the cadence of almost one hour to few days to resolve the wave optics features of the light curves to discover PBHs and determine the fraction of dark matter made of sublunar PBHs as well as their mass function.

Searching for the QCD Axion with Gravitational Microlensing

NASA Astrophysics Data System (ADS)

Fairbairn, Malcolm; Marsh, David J. E.; Quevillon, Jérémie

2017-07-01

The phase transition responsible for axion dark matter (DM) production can create large amplitude isocurvature perturbations, which collapse into dense objects known as axion miniclusters. We use microlensing data from the EROS survey and from recent observations with the Subaru Hyper Suprime Cam to place constraints on the minicluster scenario. We compute the microlensing event rate for miniclusters, treating them as spatially extended objects. Using the published bounds on the number of microlensing events, we bound the fraction of DM collapsed into miniclusters fMC. For an axion with temperature-dependent mass consistent with the QCD axion, we find fMC<0.083 (ma/100 μ eV )0.12 , which represents the first observational constraint on the minicluster fraction. We forecast that a high-efficiency observation of around ten nights with Subaru would be sufficient to constrain fMC≲0.004 over the entire QCD axion mass range. We make various approximations to derive these constraints, and dedicated analyses by the observing teams of EROS and Subaru are necessary to confirm our results. If accurate theoretical predictions for fMC can be made in the future, then microlensing can be used to exclude or discover the QCD axion. Further details of our computations are presented in a companion paper [M. Fairbairn, D. J. E. Marsh, J. Quevillon, and S. Rozier (to be published)].

Extended source effect on microlensing light curves by an Ellis wormhole

NASA Astrophysics Data System (ADS)

Tsukamoto, Naoki; Gong, Yungui

2018-04-01

We can survey an Ellis wormhole which is the simplest Morris-Thorne wormhole in our Galaxy with microlensing. The light curve of a point source microlensed by the Ellis wormhole shows approximately 4% demagnification while the total magnification of images lensed by a Schwarzschild lens is always larger than unity. We investigate an extended source effect on the light curves microlensed by the Ellis wormhole. We show that the depth of the gutter of the light curves of an extended source is smaller than the one of a point source since the magnified part of the extended source cancels the demagnified part out. We can, however, distinguish between the light curves of the extended source microlensed by the Ellis wormhole and the ones by the Schwarzschild lens in their shapes even if the size of the source is a few times larger than the size of an Einstein ring on a source plane. If the relative velocity of a star with the radius of 1 06 km at 8 kpc in the bulge of our Galaxy against an observer-lens system is smaller than 10 km /s on a source plane, we can detect microlensing of the star lensed by the Ellis wormhole with the throat radius of 1 km at 4 kpc.

Microlensing Signature of Binary Black Holes

NASA Technical Reports Server (NTRS)

Schnittman, Jeremy; Sahu, Kailash; Littenberg, Tyson

2012-01-01

We calculate the light curves of galactic bulge stars magnified via microlensing by stellar-mass binary black holes along the line-of-sight. We show the sensitivity to measuring various lens parameters for a range of survey cadences and photometric precision. Using public data from the OGLE collaboration, we identify two candidates for massive binary systems, and discuss implications for theories of star formation and binary evolution.

Gravitational microlensing of gamma-ray bursts

NASA Technical Reports Server (NTRS)

Mao, Shude

1993-01-01

A Monte Carlo code is developed to calculate gravitational microlensing in three dimensions when the lensing optical depth is low or moderate (not greater than 0.25). The code calculates positions of microimages and time delays between the microimages. The majority of lensed gamma-ray bursts should show a simple double-burst structure, as predicted by a single point mass lens model. A small fraction should show complicated multiple events due to the collective effects of several point masses (black holes). Cosmological models with a significant fraction of mass density in massive compact objects can be tested by searching for microlensing events in the current BATSE data. Our catalog generated by 10,000 Monte Carlo models is accessible through the computer network. The catalog can be used to take realistic selection effects into account.

Liquid Tunable Microlenses based on MEMS techniques

PubMed Central

Zeng, Xuefeng; Jiang, Hongrui

2013-01-01

The recent rapid development in microlens technology has provided many opportunities for miniaturized optical systems, and has found a wide range of applications. Of these microlenses, tunable-focus microlenses are of special interest as their focal lengths can be tuned using micro-scale actuators integrated with the lens structure. Realization of such tunable microlens generally relies on the microelectromechanical system (MEMS) technologies. Here, we review the recent progress in tunable liquid microlenses. The underlying physics relevant to these microlenses are first discussed, followed by description of three main categories of tunable microlenses involving MEMS techniques, mechanically driven, electrically driven, and those integrated within microfluidic systems. PMID:24163480

Precise Time Delays from Strongly Gravitationally Lensed Type Ia Supernovae with Chromatically Microlensed Images

NASA Astrophysics Data System (ADS)

Goldstein, Daniel A.; Nugent, Peter E.; Kasen, Daniel N.; Collett, Thomas E.

2018-03-01

Time delays between the multiple images of strongly gravitationally lensed Type Ia supernovae (glSNe Ia) have the potential to deliver precise cosmological constraints, but the effects of microlensing on time delay extraction have not been studied in detail. Here we quantify the effect of microlensing on the glSN Ia yield of the Large Synoptic Survey Telescope (LSST) and the effect of microlensing on the precision and accuracy of time delays that can be extracted from LSST glSNe Ia. Microlensing has a negligible effect on the LSST glSN Ia yield, but it can be increased by a factor of ∼2 over previous predictions to 930 systems using a novel photometric identification technique based on spectral template fitting. Crucially, the microlensing of glSNe Ia is achromatic until three rest-frame weeks after the explosion, making the early-time color curves microlensing-insensitive time delay indicators. By fitting simulated flux and color observations of microlensed glSNe Ia with their underlying, unlensed spectral templates, we forecast the distribution of absolute time delay error due to microlensing for LSST, which is unbiased at the sub-percent level and peaked at 1% for color curve observations in the achromatic phase, while for light-curve observations it is comparable to state-of-the-art mass modeling uncertainties (4%). About 70% of LSST glSN Ia images should be discovered during the achromatic phase, indicating that microlensing time delay uncertainties can be minimized if prompt multicolor follow-up observations are obtained. Accounting for microlensing, the 1–2 day time delay on the recently discovered glSN Ia iPTF16geu can be measured to 40% precision, limiting its cosmological utility.

Precise Time Delays from Strongly Gravitationally Lensed Type Ia Supernovae with Chromatically Microlensed Images

DOE PAGES

Goldstein, Daniel A.; Nugent, Peter E.; Kasen, Daniel N.; ...

2018-03-01

Time delays between the multiple images of strongly gravitationally lensed Type Ia supernovae (glSNe Ia) have the potential to deliver precise cosmological constraints, but the effects of microlensing on time delay extraction have not been studied in detail. Here we quantify the effect of microlensing on the glSN Ia yield of the Large Synoptic Survey Telescope (LSST) and the effect of microlensing on the precision and accuracy of time delays that can be extracted from LSST glSNe Ia. Microlensing has a negligible effect on the LSST glSN Ia yield, but it can be increased by a factor of ~2 overmore » previous predictions to 930 systems using a novel photometric identification technique based on spectral template fitting. Crucially, the microlensing of glSNe Ia is achromatic until three rest-frame weeks after the explosion, making the early-time color curves microlensing-insensitive time delay indicators. By fitting simulated flux and color observations of microlensed glSNe Ia with their underlying, unlensed spectral templates, we forecast the distribution of absolute time delay error due to microlensing for LSST, which is unbiased at the sub-percent level and peaked at 1% for color curve observations in the achromatic phase, while for light-curve observations it is comparable to state-of-the-art mass modeling uncertainties (4%). About 70% of LSST glSN Ia images should be discovered during the achromatic phase, indicating that microlensing time delay uncertainties can be minimized if prompt multicolor follow-up observations are obtained. Lastly, accounting for microlensing, the 1-2 day time delay on the recently discovered glSN Ia iPTF16geu can be measured to 40% precision, limiting its cosmological utility.« less

Precise Time Delays from Strongly Gravitationally Lensed Type Ia Supernovae with Chromatically Microlensed Images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldstein, Daniel A.; Nugent, Peter E.; Kasen, Daniel N.

Time delays between the multiple images of strongly gravitationally lensed Type Ia supernovae (glSNe Ia) have the potential to deliver precise cosmological constraints, but the effects of microlensing on time delay extraction have not been studied in detail. Here we quantify the effect of microlensing on the glSN Ia yield of the Large Synoptic Survey Telescope (LSST) and the effect of microlensing on the precision and accuracy of time delays that can be extracted from LSST glSNe Ia. Microlensing has a negligible effect on the LSST glSN Ia yield, but it can be increased by a factor of ~2 overmore » previous predictions to 930 systems using a novel photometric identification technique based on spectral template fitting. Crucially, the microlensing of glSNe Ia is achromatic until three rest-frame weeks after the explosion, making the early-time color curves microlensing-insensitive time delay indicators. By fitting simulated flux and color observations of microlensed glSNe Ia with their underlying, unlensed spectral templates, we forecast the distribution of absolute time delay error due to microlensing for LSST, which is unbiased at the sub-percent level and peaked at 1% for color curve observations in the achromatic phase, while for light-curve observations it is comparable to state-of-the-art mass modeling uncertainties (4%). About 70% of LSST glSN Ia images should be discovered during the achromatic phase, indicating that microlensing time delay uncertainties can be minimized if prompt multicolor follow-up observations are obtained. Lastly, accounting for microlensing, the 1-2 day time delay on the recently discovered glSN Ia iPTF16geu can be measured to 40% precision, limiting its cosmological utility.« less

Accelerating gravitational microlensing simulations using the Xeon Phi coprocessor

NASA Astrophysics Data System (ADS)

Chen, B.; Kantowski, R.; Dai, X.; Baron, E.; Van der Mark, P.

2017-04-01

Recently Graphics Processing Units (GPUs) have been used to speed up very CPU-intensive gravitational microlensing simulations. In this work, we use the Xeon Phi coprocessor to accelerate such simulations and compare its performance on a microlensing code with that of NVIDIA's GPUs. For the selected set of parameters evaluated in our experiment, we find that the speedup by Intel's Knights Corner coprocessor is comparable to that by NVIDIA's Fermi family of GPUs with compute capability 2.0, but less significant than GPUs with higher compute capabilities such as the Kepler. However, the very recently released second generation Xeon Phi, Knights Landing, is about 5.8 times faster than the Knights Corner, and about 2.9 times faster than the Kepler GPU used in our simulations. We conclude that the Xeon Phi is a very promising alternative to GPUs for modern high performance microlensing simulations.

GERLUMPH DATA RELEASE 1: HIGH-RESOLUTION COSMOLOGICAL MICROLENSING MAGNIFICATION MAPS AND eResearch TOOLS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vernardos, G.; Fluke, C. J.; Croton, D.

2014-03-01

As synoptic all-sky surveys begin to discover new multiply lensed quasars, the flow of data will enable statistical cosmological microlensing studies of sufficient size to constrain quasar accretion disk and supermassive black hole properties. In preparation for this new era, we are undertaking the GPU-Enabled, High Resolution cosmological MicroLensing parameter survey (GERLUMPH). We present here the GERLUMPH Data Release 1, which consists of 12,342 high resolution cosmological microlensing magnification maps and provides the first uniform coverage of the convergence, shear, and smooth matter fraction parameter space. We use these maps to perform a comprehensive numerical investigation of the mass-sheet degeneracy,more » finding excellent agreement with its predictions. We study the effect of smooth matter on microlensing induced magnification fluctuations. In particular, in the minima and saddle-point regions, fluctuations are enhanced only along the critical line, while in the maxima region they are always enhanced for high smooth matter fractions (≈0.9). We describe our approach to data management, including the use of an SQL database with a Web interface for data access and online analysis, obviating the need for individuals to download large volumes of data. In combination with existing observational databases and online applications, the GERLUMPH archive represents a fundamental component of a new microlensing eResearch cloud. Our maps and tools are publicly available at http://gerlumph.swin.edu.au/.« less

Korea Microlensing Telescope Network Microlensing Events from 2015: Event-finding Algorithm, Vetting, and Photometry

NASA Astrophysics Data System (ADS)

Kim, D.-J.; Kim, H.-W.; Hwang, K.-H.; Albrow, M. D.; Chung, S.-J.; Gould, A.; Han, C.; Jung, Y. K.; Ryu, Y.-H.; Shin, I.-G.; Yee, J. C.; Zhu, W.; Cha, S.-M.; Kim, S.-L.; Lee, C.-U.; Lee, D.-J.; Lee, Y.; Park, B.-G.; Pogge, R. W.; The KMTNet Collaboration

2018-02-01

We present microlensing events in the 2015 Korea Microlensing Telescope Network (KMTNet) data and our procedure for identifying these events. In particular, candidates were detected with a novel “completed-event” microlensing event-finder algorithm. The algorithm works by making linear fits to a ({t}0,{t}{eff},{u}0) grid of point-lens microlensing models. This approach is rendered computationally efficient by restricting u 0 to just two values (0 and 1), which we show is quite adequate. The implementation presented here is specifically tailored to the commission-year character of the 2015 data, but the algorithm is quite general and has already been applied to a completely different (non-KMTNet) data set. We outline expected improvements for 2016 and future KMTNet data. The light curves of the 660 “clear microlensing” and 182 “possible microlensing” events that were found in 2015 are presented along with our policy for their public release.

The Near-Earth Object Camera: A Next-Generation Minor Planet Survey

NASA Astrophysics Data System (ADS)

Mainzer, Amy K.; Wright, Edward L.; Bauer, James; Grav, Tommy; Cutri, Roc M.; Masiero, Joseph; Nugent, Carolyn R.

2015-11-01

The Near-Earth Object Camera (NEOCam) is a next-generation asteroid and comet survey designed to discover, characterize, and track large numbers of minor planets using a 50 cm infrared telescope located at the Sun-Earth L1 Lagrange point. Proposed to NASA's Discovery program, NEOCam is designed to carry out a comprehensive inventory of the small bodies in the inner regions of our solar system. It address three themes: 1) quantify the potential hazard that near-Earth objects may pose to Earth; 2) study the origins and evolution of our solar system as revealed by its small body populations; and 3) identify the best destinations for future robotic and human exploration. With a dual channel infrared imager that observes at 4-5 and 6-10 micron bands simultaneously through the use of a beamsplitter, NEOCam enables measurements of asteroid diameters and thermal inertia. NEOCam complements existing and planned visible light surveys in terms of orbital element phase space and wavelengths, since albedos can be determined for objects with both visible and infrared flux measurements. NEOCam was awarded technology development funding in 2011 to mature the necessary megapixel infrared detectors.

NASA's Next Generation Space Geodesy Program

NASA Technical Reports Server (NTRS)

Pearlman, M. R.; Frey, H. V.; Gross, R. S.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry J. F.; Merkowitz, S. M.; Noll, C. E.; Pavilis, E. C.;

NASA's Next Generation Space Geodesy Program

NASA Technical Reports Server (NTRS)

Merkowitz, S. M.; Desai, S. D.; Gross, R. S.; Hillard, L. M.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Murphy, D.; Noll, C. E.;

Probing Extragalactic Planets Using Quasar Microlensing

NASA Astrophysics Data System (ADS)

Dai, Xinyu; Guerras, Eduardo

2018-02-01

Previously, planets have been detected only in the Milky Way galaxy. Here, we show that quasar microlensing provides a means to probe extragalactic planets in the lens galaxy, by studying the microlensing properties of emission close to the event horizon of the supermassive black hole of the background quasar, using the current generation telescopes. We show that a population of unbound planets between stars with masses ranging from Moon to Jupiter masses is needed to explain the frequent Fe Kα line energy shifts observed in the gravitationally lensed quasar RXJ 1131–1231 at a lens redshift of z = 0.295 or 3.8 billion lt-yr away. We constrain the planet mass-fraction to be larger than 0.0001 of the halo mass, which is equivalent to 2000 objects ranging from Moon to Jupiter mass per main-sequence star.

Quasar microlensing models with constraints on the Quasar light curves

NASA Astrophysics Data System (ADS)

Tie, S. S.; Kochanek, C. S.

2018-01-01

Quasar microlensing analyses implicitly generate a model of the variability of the source quasar. The implied source variability may be unrealistic yet its likelihood is generally not evaluated. We used the damped random walk (DRW) model for quasar variability to evaluate the likelihood of the source variability and applied the revized algorithm to a microlensing analysis of the lensed quasar RX J1131-1231. We compared estimates of the size of the quasar disc and the average stellar mass of the lens galaxy with and without applying the DRW likelihoods for the source variability model and found no significant effect on the estimated physical parameters. The most likely explanation is that unreliastic source light-curve models are generally associated with poor microlensing fits that already make a negligible contribution to the probability distributions of the derived parameters.

Generation of maximally entangled states and coherent control in quantum dot microlenses

NASA Astrophysics Data System (ADS)

Bounouar, Samir; de la Haye, Christoph; Strauß, Max; Schnauber, Peter; Thoma, Alexander; Gschrey, Manuel; Schulze, Jan-Hindrik; Strittmatter, André; Rodt, Sven; Reitzenstein, Stephan

2018-04-01

The integration of entangled photon emitters in nanophotonic structures designed for the broadband enhancement of photon extraction is a major challenge for quantum information technologies. We study the potential of quantum dot (QD) microlenses as efficient emitters of maximally entangled photons. For this purpose, we perform quantum tomography measurements on InGaAs QDs integrated deterministically into microlenses. Even though the studied QDs show non-zero excitonic fine-structure splitting (FSS), polarization entanglement can be prepared with a fidelity close to unity. The quality of the measured entanglement is only dependent on the temporal resolution of the applied single-photon detectors compared to the period of the excitonic phase precession imposed by the FSS. Interestingly, entanglement is kept along the full excitonic wave-packet and is not affected by decoherence. Furthermore, coherent control of the upper biexcitonic state is demonstrated.

WFIRST: Microlensing Parallax Observations from K2 in the Exoplanet Microlensing Field

NASA Astrophysics Data System (ADS)

Ranc, Clement; Radek Poleski, David Bennett, K2C9 Microlensing Science Experiment Team

2018-01-01

The recent explosion in our understanding of exoplanetary systems has been driven primarily by the Kepler mission, which has replaced radial velocities as our main planet discovery method. While Kepler has provided a large sample of planets that will allow a robust statistical determination of the properties of exoplanets in close orbits about their host stars, the Kepler mission was stopped shortly after the start of its 5th year. This led to the Kepler 2 (K2) mission, which could observe up to 18 different fields in the ecliptic plane, including a fraction of the WFIRST microlensing field. The K2 mission has focused on lower mass host stars and spending one observing campaign in the Galactic bulge to make use of Kepler’s orbit to determine the masses and distances to microlensing systems via the microlensing parallax effect. These K2 Campaign 9 observations help to develop the microlensing planet detection method, which will be employed by the WFIRST mission that will extend the statistical census of exoplanets to include low-mass planets in wide orbits. While the photometric light curve of a microlensing event observed from the ground provides important constraints on the lens physical parameters, in many cases the lens mass and distance from Earth remain degenerated. The poster will show how simultaneous space- and ground-based observations can break this mass-distance degeneracy. This method will be used for a fraction of the events observed by WFIRST. Finally, the poster will present a new method to correct the K2 photometry from the correlated systematic noise. This investigation helps in characterizing the properties of the lens stars and source stars in one WFIRST field with high extinction.

NASA's Next Generation Space Geodesy Network

NASA Technical Reports Server (NTRS)

Desai, S. D.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Merkowitz, S. M.; Murphy, D.; Noll, C. E.;

WFIRST: Searching for Microlens Planets in Very Wide Orbits and the MOA Microlensing Data Release

NASA Astrophysics Data System (ADS)

Hirao, Yuki; Bennett, David; Sumi, Takahiro; MOA Collaboration

2018-01-01

Gravitational microlensing is an unique technique to detect exoplanets down to low mass planets beyond the snow line because it is sensitive to planets orbiting near the Einstein ring radius of a few AU away from its host star, which is complementary to the other methods. Detecting such planets are important for understanding the formation of our solar system because gas giants and ice giants planets are believed to be formed beyond the snow line, where the protoplanetary disk is cold enough for ice to condense, in the core accretion theory. Microlensing Observations in Astrophysics (MOA) group has conducted high cadence survey observations towards the Galactic bulge to detect exoplanets since 2006 at Mt.John University Observatory in NZ using MOA-II 1.8 meter telescope equipped with a very wide field-of-view MOA-cam3 CCD camera. MOA has alerted about 600 microlensing events every year and detected dozens of exoplanets in wide orbits. Future space telescope, WFIRST will conduct survey observations towards the Galactic bulge and is expected to detect thousands of planets in wide orbit via microlensing to complete the census of exoplanets begun by Kepler Space telescope which found planets in close orbits via transit method. To contribute to the WFIRST and make the microlensing community larger, MOA will open its data from 2006 to 2014 to the public. Through the off-line analysis, we have found some short binary events which were not detected in the real time analysis. Short-timescale microlensing events are important because they are candidates of free-floating or wide-separation planets. The poster will present the data release and some results of the analysis of short-timescale binary events.

WFIRST: Microlensing Analysis Data Challenge

NASA Astrophysics Data System (ADS)

Street, Rachel; WFIRST Microlensing Science Investigation Team

2018-01-01

WFIRST will produce thousands of high cadence, high photometric precision lightcurves of microlensing events, from which a wealth of planetary and stellar systems will be discovered. However, the analysis of such lightcurves has historically been very time consuming and expensive in both labor and computing facilities. This poses a potential bottleneck to deriving the full science potential of the WFIRST mission. To address this problem, the WFIRST Microlensing Science Investigation Team designing a series of data challenges to stimulate research to address outstanding problems of microlensing analysis. These range from the classification and modeling of triple lens events to methods to efficiently yet thoroughly search a high-dimensional parameter space for the best fitting models.

New Self-lensing Models of the Small Magellanic Cloud: Can Gravitational Microlensing Detect Extragalactic Exoplanets?

NASA Astrophysics Data System (ADS)

Mróz, Przemek; Poleski, Radosław

2018-04-01

We use three-dimensional distributions of classical Cepheids and RR Lyrae stars in the Small Magellanic Cloud (SMC) to model the stellar density distribution of a young and old stellar population in that galaxy. We use these models to estimate the microlensing self-lensing optical depth to the SMC, which is in excellent agreement with the observations. Our models are consistent with the total stellar mass of the SMC of about 1.0× {10}9 {M}ȯ under the assumption that all microlensing events toward this galaxy are caused by self-lensing. We also calculate the expected event rates and estimate that future large-scale surveys, like the Large Synoptic Survey Telescope (LSST), will be able to detect up to a few dozen microlensing events in the SMC annually. If the planet frequency in the SMC is similar to that in the Milky Way, a few extragalactic planets can be detected over the course of the LSST survey, provided significant changes in the SMC observing strategy are devised. A relatively small investment of LSST resources can give us a unique probe of the population of extragalactic exoplanets.

Astrometric Observation of MACHO Gravitational Microlensing

NASA Technical Reports Server (NTRS)

Boden, A. F.; Shao, M.; Van Buren, D.

1997-01-01

This paper discusses the prospects for astrometric observation of MACHO gravitational microlensing events. We derive the expected astrometric observables for a simple microlensing event assuming a dark MACHO, and demonstrate that accurate astrometry can determine the lens mass, distance, and proper motion in a very general fashion.

Next generation initiation techniques

NASA Technical Reports Server (NTRS)

Warner, Tom; Derber, John; Zupanski, Milija; Cohn, Steve; Verlinde, Hans

1993-01-01

Four-dimensional data assimilation strategies can generally be classified as either current or next generation, depending upon whether they are used operationally or not. Current-generation data-assimilation techniques are those that are presently used routinely in operational-forecasting or research applications. They can be classified into the following categories: intermittent assimilation, Newtonian relaxation, and physical initialization. It should be noted that these techniques are the subject of continued research, and their improvement will parallel the development of next generation techniques described by the other speakers. Next generation assimilation techniques are those that are under development but are not yet used operationally. Most of these procedures are derived from control theory or variational methods and primarily represent continuous assimilation approaches, in which the data and model dynamics are 'fitted' to each other in an optimal way. Another 'next generation' category is the initialization of convective-scale models. Intermittent assimilation systems use an objective analysis to combine all observations within a time window that is centered on the analysis time. Continuous first-generation assimilation systems are usually based on the Newtonian-relaxation or 'nudging' techniques. Physical initialization procedures generally involve the use of standard or nonstandard data to force some physical process in the model during an assimilation period. Under the topic of next-generation assimilation techniques, variational approaches are currently being actively developed. Variational approaches seek to minimize a cost or penalty function which measures a model's fit to observations, background fields and other imposed constraints. Alternatively, the Kalman filter technique, which is also under investigation as a data assimilation procedure for numerical weather prediction, can yield acceptable initial conditions for mesoscale models. The

Candidate Binary Microlensing Events from the MACHO Project

NASA Astrophysics Data System (ADS)

Becker, A. C.; Alcock, C.; Allsman, R. A.; Alves, D. R.; Axelrod, T. S.; Bennett, D. P.; Cook, K. H.; Drake, A. J.; Freeman, K. C.; Griest, K.; King, L. J.; Lehner, M. J.; Marshall, S. L.; Minniti, D.; Peterson, B. A.; Popowski, P.; Pratt, M. R.; Quinn, P. J.; Rodgers, A. W.; Stubbs, C. W.; Sutherland, W.; Tomaney, A.; Vandehei, T.; Welch, D. L.; Baines, D.; Brakel, A.; Crook, B.; Howard, J.; Leach, T.; McDowell, D.; McKeown, S.; Mitchell, J.; Moreland, J.; Pozza, E.; Purcell, P.; Ring, S.; Salmon, A.; Ward, K.; Wyper, G.; Heller, A.; Kaspi, S.; Kovo, O.; Maoz, D.; Retter, A.; Rhie, S. H.; Stetson, P.; Walker, A.; MACHO Collaboration

1998-12-01

We present the lightcurves of 22 gravitational microlensing events from the first six years of the MACHO Project gravitational microlensing survey which are likely examples of lensing by binary systems. These events were selected from a total sample of ~ 300 events which were either detected by the MACHO Alert System or discovered through retrospective analyses of the MACHO database. Many of these events appear to have undergone a caustic or cusp crossing, and 2 of the events are well fit with lensing by binary systems with large mass ratios, indicating secondary companions of approximately planetary mass. The event rate is roughly consistent with predictions based upon our knowledge of the properties of binary stars. The utility of binary lensing in helping to solve the Galactic dark matter problem is demonstrated with analyses of 3 binary microlensing events seen towards the Magellanic Clouds. Source star resolution during caustic crossings in 2 of these events allows us to estimate the location of the lensing systems, assuming each source is a single star and not a short period binary. * MACHO LMC-9 appears to be a binary lensing event with a caustic crossing partially resolved in 2 observations. The resulting lens proper motion appears too small for a single source and LMC disk lens. However, it is considerably less likely to be a single source star and Galactic halo lens. We estimate the a priori probability of a short period binary source with a detectable binary character to be ~ 10 %. If the source is also a binary, then we currently have no constraints on the lens location. * The most recent of these events, MACHO 98-SMC-1, was detected in real-time. Follow-up observations by the MACHO/GMAN, PLANET, MPS, EROS and OGLE microlensing collaborations lead to the robust conclusion that the lens likely resides in the SMC.

78 FR 64404 - Next Generation 911; Text-to-911; Next Generation 911 Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-29

... preamble, the Federal Communications Commission amends 47 CFR part 20 as follows: PART 20--COMMERCIAL... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 20 [PS Docket Nos. 11-153 and 10-255; FCC 13-127] Next Generation 911; Text-to-911; Next Generation 911 Applications AGENCY: Federal Communications...

Light-focusing human micro-lenses generated from pluripotent stem cells model lens development and drug-induced cataract in vitro

PubMed Central

Murphy, Patricia; Kabir, Md Humayun; Srivastava, Tarini; Mason, Michele E.; Dewi, Chitra U.; Lim, Seakcheng; Yang, Andrian; Djordjevic, Djordje; Killingsworth, Murray C.; Ho, Joshua W. K.; Harman, David G.

2018-01-01

ABSTRACT Cataracts cause vision loss and blindness by impairing the ability of the ocular lens to focus light onto the retina. Various cataract risk factors have been identified, including drug treatments, age, smoking and diabetes. However, the molecular events responsible for these different forms of cataract are ill-defined, and the advent of modern cataract surgery in the 1960s virtually eliminated access to human lenses for research. Here, we demonstrate large-scale production of light-focusing human micro-lenses from spheroidal masses of human lens epithelial cells purified from differentiating pluripotent stem cells. The purified lens cells and micro-lenses display similar morphology, cellular arrangement, mRNA expression and protein expression to human lens cells and lenses. Exposing the micro-lenses to the emergent cystic fibrosis drug Vx-770 reduces micro-lens transparency and focusing ability. These human micro-lenses provide a powerful and large-scale platform for defining molecular disease mechanisms caused by cataract risk factors, for anti-cataract drug screening and for clinically relevant toxicity assays. PMID:29217756

Light-focusing human micro-lenses generated from pluripotent stem cells model lens development and drug-induced cataract in vitro.

PubMed

Murphy, Patricia; Kabir, Md Humayun; Srivastava, Tarini; Mason, Michele E; Dewi, Chitra U; Lim, Seakcheng; Yang, Andrian; Djordjevic, Djordje; Killingsworth, Murray C; Ho, Joshua W K; Harman, David G; O'Connor, Michael D

2018-01-09

Cataracts cause vision loss and blindness by impairing the ability of the ocular lens to focus light onto the retina. Various cataract risk factors have been identified, including drug treatments, age, smoking and diabetes. However, the molecular events responsible for these different forms of cataract are ill-defined, and the advent of modern cataract surgery in the 1960s virtually eliminated access to human lenses for research. Here, we demonstrate large-scale production of light-focusing human micro-lenses from spheroidal masses of human lens epithelial cells purified from differentiating pluripotent stem cells. The purified lens cells and micro-lenses display similar morphology, cellular arrangement, mRNA expression and protein expression to human lens cells and lenses. Exposing the micro-lenses to the emergent cystic fibrosis drug Vx-770 reduces micro-lens transparency and focusing ability. These human micro-lenses provide a powerful and large-scale platform for defining molecular disease mechanisms caused by cataract risk factors, for anti-cataract drug screening and for clinically relevant toxicity assays. © 2018. Published by The Company of Biologists Ltd.

Launching the Next Generation IODP Site Survey Data Bank

NASA Astrophysics Data System (ADS)

Miller, S. P.; Helly, J.; Clark, D.; Eakins, B.; Sutton, D.; Weatherford, J.; Thatch, G.; Miville, B.; Zelt, B.

2005-12-01

The next generation all-digital Site Survey Data Bank (SSDB) became operational on August 15, 2005 as an online resource for Integrated Ocean Drilling Program (IODP) proponents, reviewers, panels and operations, worldwide. There are currently 123 active proposals for drilling at sites distributed across the globe, involving nearly 1000 proponents from more than 40 countries. The goal is to provide an authoritative, persistent, secure, password-controlled and easily-used home for contributed data objects, as proposals evolve through their life cycle from preliminary phases to planned drilling expeditions. Proposal status can be monitored graphically by proposal number, data type or date. A Java SSDBviewer allows discovery of all proposal data objects, displayed over a basemap of global topography, crustal age or other custom maps. Data can be viewed or downloaded under password control. Webform interfaces assist with the uploading of data and metadata. Thirty four different standard data types are currently supported. The system was designed as a fully functioning digital library, not just a database or a web archive, drawing upon the resources of the SIOExplorer Digital Library project. Blocks of metadata are organized to support discovery and use, as appropriate for each data type. The SSDB has been developed by a UCSD team of researchers and computer scientists at the Scripps Institution of Oceanography and the San Diego Supercomputer Center, under contract with IODP Management International Inc., supported by NSF OCE 0432224.

Binary Microlensing Events from the MACHO Project

NASA Astrophysics Data System (ADS)

Alcock, C.; Allsman, R. A.; Alves, D.; Axelrod, T. S.; Baines, D.; Becker, A. C.; Bennett, D. P.; Bourke, A.; Brakel, A.; Cook, K. H.; Crook, B.; Crouch, A.; Dan, J.; Drake, A. J.; Fragile, P. C.; Freeman, K. C.; Gal-Yam, A.; Geha, M.; Gray, J.; Griest, K.; Gurtierrez, A.; Heller, A.; Howard, J.; Johnson, B. R.; Kaspi, S.; Keane, M.; Kovo, O.; Leach, C.; Leach, T.; Leibowitz, E. M.; Lehner, M. J.; Lipkin, Y.; Maoz, D.; Marshall, S. L.; McDowell, D.; McKeown, S.; Mendelson, H.; Messenger, B.; Minniti, D.; Nelson, C.; Peterson, B. A.; Popowski, P.; Pozza, E.; Purcell, P.; Pratt, M. R.; Quinn, J.; Quinn, P. J.; Rhie, S. H.; Rodgers, A. W.; Salmon, A.; Shemmer, O.; Stetson, P.; Stubbs, C. W.; Sutherland, W.; Thomson, S.; Tomaney, A.; Vandehei, T.; Walker, A.; Ward, K.; Wyper, G.

2000-09-01

We present the light curves of 21 gravitational microlensing events from the first six years of the MACHO Project gravitational microlensing survey that are likely examples of lensing by binary systems. These events were manually selected from a total sample of ~350 candidate microlensing events that were either detected by the MACHO Alert System or discovered through retrospective analyses of the MACHO database. At least 14 of these 21 events exhibit strong (caustic) features, and four of the events are well fit with lensing by large mass ratio (brown dwarf or planetary) systems, although these fits are not necessarily unique. The total binary event rate is roughly consistent with predictions based upon our knowledge of the properties of binary stars, but a precise comparison cannot be made without a determination of our binary lens event detection efficiency. Toward the Galactic bulge, we find a ratio of caustic crossing to noncaustic crossing binary lensing events of 12:4, excluding one event for which we present two fits. This suggests significant incompleteness in our ability to detect and characterize noncaustic crossing binary lensing. The distribution of mass ratios, N(q), for these binary lenses appears relatively flat. We are also able to reliably measure source-face crossing times in four of the bulge caustic crossing events, and recover from them a distribution of lens proper motions, masses, and distances consistent with a population of Galactic bulge lenses at a distance of 7+/-1 kpc. This analysis yields two systems with companions of ~0.05 Msolar.

The advantages of using a Lucky Imaging camera for observations of microlensing events

NASA Astrophysics Data System (ADS)

Sajadian, Sedighe; Rahvar, Sohrab; Dominik, Martin; Hundertmark, Markus

2016-05-01

In this work, we study the advantages of using a Lucky Imaging camera for the observations of potential planetary microlensing events. Our aim is to reduce the blending effect and enhance exoplanet signals in binary lensing systems composed of an exoplanet and the corresponding parent star. We simulate planetary microlensing light curves based on present microlensing surveys and follow-up telescopes where one of them is equipped with a Lucky Imaging camera. This camera is used at the Danish 1.54-m follow-up telescope. Using a specific observational strategy, for an Earth-mass planet in the resonance regime, where the detection probability in crowded fields is smaller, Lucky Imaging observations improve the detection efficiency which reaches 2 per cent. Given the difficulty of detecting the signal of an Earth-mass planet in crowded-field imaging even in the resonance regime with conventional cameras, we show that Lucky Imaging can substantially improve the detection efficiency.

Theory of dispersive microlenses

NASA Technical Reports Server (NTRS)

Herman, B.; Gal, George

1993-01-01

A dispersive microlens is a miniature optical element which simultaneously focuses and disperses light. Arrays of dispersive mircolenses have potential applications in multicolor focal planes. They have a 100 percent optical fill factor and can focus light down to detectors of diffraction spot size, freeing up areas on the focal plane for on-chip analog signal processing. Use of dispersive microlenses allows inband color separation within a pixel and perfect scene registration. A dual-color separation has the potential for temperature discrimination. We discuss the design of dispersive microlenses and present sample results for efficient designs.

Time Delay in Microlensing Event

NASA Image and Video Library

2015-04-14

This plot shows data obtained from NASA's Spitzer Space Telescope and the Optical Gravitational Lensing Experiment, or OGLE, telescope located in Chile, during a "microlensing" event. Microlensing events occur when one star passes another, and the gravity of the foreground star causes the distant star's light to magnify and brighten. This magnification is evident in the plot, as both Spitzer and OGLE register an increase in the star's brightness. If the foreground star is circled by a planet, the planet's gravity can alter the magnification over a shorter period, seen in the plot in the form of spikes and a dip. The great distance between Spitzer, in space, and OGLE, on the ground, meant that Spitzer saw this particular microlensing event before OGLE. The offset in the timing can be used to measure the distance to the planet. In this case, the planet, called OGLE-2014-BLG-0124L, was found to be 13,000 light-years away, near the center of our Milky Way galaxy. The finding was the result of fortuitous timing because Spitzer's overall program to observe microlensing events was only just starting up in the week before the planet's effects were visible from Spitzer's vantage point. While Spitzer sees infrared light of 3.6 microns in wavelength, OGLE sees visible light of 0.8 microns. http://photojournal.jpl.nasa.gov/catalog/PIA19331

Unbound or distant planetary mass population detected by gravitational microlensing.

PubMed

2011-05-19

Since 1995, more than 500 exoplanets have been detected using different techniques, of which 12 were detected with gravitational microlensing. Most of these are gravitationally bound to their host stars. There is some evidence of free-floating planetary-mass objects in young star-forming regions, but these objects are limited to massive objects of 3 to 15 Jupiter masses with large uncertainties in photometric mass estimates and their abundance. Here, we report the discovery of a population of unbound or distant Jupiter-mass objects, which are almost twice (1.8(+1.7)(-0.8)) as common as main-sequence stars, based on two years of gravitational microlensing survey observations towards the Galactic Bulge. These planetary-mass objects have no host stars that can be detected within about ten astronomical units by gravitational microlensing. However, a comparison with constraints from direct imaging suggests that most of these planetary-mass objects are not bound to any host star. An abrupt change in the mass function at about one Jupiter mass favours the idea that their formation process is different from that of stars and brown dwarfs. They may have formed in proto-planetary disks and subsequently scattered into unbound or very distant orbits.

Brown Dwarf Microlensing Diagram

NASA Image and Video Library

2016-11-10

For the first time, two space-based telescopes have teamed up with ground-based observatories to observe a microlensing event, a magnification of the light of a distant star due to the gravitational effects of an unseen object in the foreground. In this case, the cause of the microlensing event was a brown dwarf, dubbed OGLE-2015-BLG-1319, orbiting a star. In terms of mass, brown dwarfs fall somewhere between the size of the largest planets and the smallest stars. Curiously, scientists have found that, for stars roughly the mass of our sun, less than 1 percent have a brown dwarf orbiting within 3 AU (1 AU is the distance between Earth and the sun). This newly discovered brown dwarf may fall in that distance range. This microlensing event was observed by ground-based telescopes looking for these uncommon events, and subsequently seen by NASA's Spitzer and Swift space telescopes. As the diagram shows, Spitzer and Swift offer additional vantage points for viewing this chance alignment. While Swift orbits close to Earth, and saw (blue diamonds) essentially the same change in light that the ground-based telescopes measured (grey markers), Spitzer's location much farther away from Earth gave it a very different perspective on the event (red circles). In particular, Spitzer's vantage point resulted in a time lag in the microlensing event it observed, compared to what was seen by Swift and the ground-based telescope. This offset allowed astronomers to determine the distance to OGLE-2015-BLG-1319 as well as its mass: around 30-65 times that of Jupiter. http://photojournal.jpl.nasa.gov/catalog/PIA21077

Hubble's Next Generation Spectral Library

NASA Astrophysics Data System (ADS)

Heap, Sara R.; Lindler, D.

2008-03-01

Spectroscopic surveys of galaxies at z 1 or more bring the rest-frame ultraviolet into view of large, ground-based telescopes. This spectral region is rich in diagnostics, but these diagnostics have not yet been calibrated in terms of the properties of the responsible stellar population(s). Such calibrations are now possible with Hubble's Next Generation Spectral Library (NGSL). This library contains UV-optical spectra (0.2-1.0 microns) of 378 stars having a wide range in temperature, luminosity, and metallicity. We have derived the basic stellar parameters from the optical spectral region (0.35 - 1.0 microns) and are using them to calibrate UV spectral diagnostic indices and colors.

Synthesizing exoplanet demographics from radial velocity and microlensing surveys. II. The frequency of planets orbiting M dwarfs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clanton, Christian; Gaudi, B. Scott, E-mail: clanton@astronomy.ohio-state.edu

2014-08-20

In contrast to radial velocity (RV) surveys, results from microlensing surveys indicate that giant planets with masses greater than the critical mass for core accretion (∼0.1 M {sub Jup}) are relatively common around low-mass stars. Using the methodology developed in the first paper, we predict the sensitivity of M-dwarf RV surveys to analogs of the population of planets inferred by microlensing. We find that RV surveys should detect a handful of super-Jovian (>M {sub Jup}) planets at the longest periods being probed. These planets are indeed found by RV surveys, implying that the demographic constraints inferred from these two methodsmore » are consistent. Finally, we combine the results from both methods to estimate planet frequencies spanning wide regions of parameter space. We find that the frequency of Jupiters and super-Jupiters (1 ≲ m{sub p} sin i/M {sub Jup} ≲ 13) with periods 1 ≤ P/days ≤ 10{sup 4} is f{sub J}=0.029{sub −0.015}{sup +0.013}, a median factor of 4.3 (1.5-14 at 95% confidence) smaller than the inferred frequency of such planets around FGK stars of 0.11 ± 0.02. However, we find the frequency of all giant planets with 30 ≲ m{sub p} sin i/M {sub ⊕} ≲ 10{sup 4} and 1 ≤ P/days ≤ 10{sup 4} to be f{sub G}=0.15{sub −0.07}{sup +0.06}, only a median factor of 2.2 (0.73-5.9 at 95% confidence) smaller than the inferred frequency of such planets orbiting FGK stars of 0.31 ± 0.07. For a more conservative definition of giant planets (50 ≲ m{sub p} sin i/M {sub ⊕} ≲ 10{sup 4}), we find f{sub G{sup ′}}=0.11±0.05, a median factor of 2.2 (0.73-6.7 at 95% confidence) smaller than that inferred for FGK stars of 0.25 ± 0.05. Finally, we find the frequency of all planets with 1 ≤ m{sub p} sin i/M {sub ⊕} ≤ 10{sup 4} and 1 ≤ P/days ≤ 10{sup 4} to be f{sub p} = 1.9 ± 0.5.« less

A Survey on Next-generation Power Grid Data Architecture

DOE Office of Scientific and Technical Information (OSTI.GOV)

You, Shutang; Zhu, Dr. Lin; Liu, Yong

2015-01-01

The operation and control of power grids will increasingly rely on data. A high-speed, reliable, flexible and secure data architecture is the prerequisite of the next-generation power grid. This paper summarizes the challenges in collecting and utilizing power grid data, and then provides reference data architecture for future power grids. Based on the data architecture deployment, related research on data architecture is reviewed and summarized in several categories including data measurement/actuation, data transmission, data service layer, data utilization, as well as two cross-cutting issues, interoperability and cyber security. Research gaps and future work are also presented.

Optimal survey strategies and predicted planet yields for the Korean microlensing telescope network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Henderson, Calen B.; Gaudi, B. Scott; Skowron, Jan

2014-10-10

The Korean Microlensing Telescope Network (KMTNet) will consist of three 1.6 m telescopes each with a 4 deg{sup 2} field of view (FoV) and will be dedicated to monitoring the Galactic Bulge to detect exoplanets via gravitational microlensing. KMTNet's combination of aperture size, FoV, cadence, and longitudinal coverage will provide a unique opportunity to probe exoplanet demographics in an unbiased way. Here we present simulations that optimize the observing strategy for and predict the planetary yields of KMTNet. We find preferences for four target fields located in the central Bulge and an exposure time of t {sub exp} = 120more » s, leading to the detection of ∼2200 microlensing events per year. We estimate the planet detection rates for planets with mass and separation across the ranges 0.1 ≤ M{sub p} /M {sub ⊕} ≤ 1000 and 0.4 ≤ a/AU ≤ 16, respectively. Normalizing these rates to the cool-planet mass function of Cassan et al., we predict KMTNet will be approximately uniformly sensitive to planets with mass 5 ≤ M{sub p} /M {sub ⊕} ≤ 1000 and will detect ∼20 planets per year per dex in mass across that range. For lower-mass planets with mass 0.1 ≤ M{sub p} /M {sub ⊕} < 5, we predict KMTNet will detect ∼10 planets per year. We also compute the yields KMTNet will obtain for free-floating planets (FFPs) and predict KMTNet will detect ∼1 Earth-mass FFP per year, assuming an underlying population of one such planet per star in the Galaxy. Lastly, we investigate the dependence of these detection rates on the number of observatories, the photometric precision limit, and optimistic assumptions regarding seeing, throughput, and flux measurement uncertainties.« less

Technology Needs for the Next Generation of NASA Science Missions

NASA Technical Reports Server (NTRS)

Anderson, David J.

2013-01-01

In-Space propulsion technologies relevant to Mars presentation is for the 14.03 Emerging Technologies for Mars Exploration panel. The talk will address propulsion technology needs for future Mars science missions, and will address electric propulsion, Earth entry vehicles, light weight propellant tanks, and the Mars ascent vehicle. The second panel presentation is Technology Needs for the Next Generation of NASA Science Missions. This talk is for 14.02 Technology Needs for the Next Generation of NASA Science Missions panel. The talk will summarize the technology needs identified in the NAC's Planetary Science Decadal Survey, and will set the stage for the talks for the 4 other panelist.

Domestic and foreign trends in the prevalence of heart failure and the necessity of next-generation artificial hearts: a survey by the Working Group on Establishment of Assessment Guidelines for Next-Generation Artificial Heart Systems.

PubMed

Tatsumi, Eisuke; Nakatani, Takeshi; Imachi, Kou; Umezu, Mitsuo; Kyo, Shun-Ei; Sase, Kazuhiro; Takatani, Setsuo; Matsuda, Hikaru

2007-01-01

A series of guidelines for development and assessment of next-generation medical devices has been drafted under an interagency collaborative project by the Ministry of Health, Labor and Welfare and the Ministry of Economy, Trade and Industry. The working group for assessment guidelines of next-generation artificial hearts reviewed the trend in the prevalence of heart failure and examined the potential usefulness of such devices in Japan and in other countries as a fundamental part of the process of establishing appropriate guidelines. At present, more than 23 million people suffer from heart failure in developed countries, including Japan. Although Japan currently has the lowest mortality from heart failure among those countries, the number of patients is gradually increasing as our lifestyle becomes more Westernized; the associated medical expenses are rapidly growing. The number of heart transplantations, however, is limited due to the overwhelming shortage of donor hearts, not only in Japan but worldwide. Meanwhile, clinical studies and surveys have revealed that the major causes of death in patients undergoing long-term use of ventricular assist devices (VADs) were infection, thrombosis, and mechanical failure, all of which are typical of VADs. It is therefore of urgent and universal necessity to develop next-generation artificial hearts that have excellent durability to provide at least 2 years of event-free operation with a superior quality of life and that can be used for destination therapy to save patients with irreversible heart failure. It is also very important to ensure that an environment that facilitates the development, testing, and approval evaluation processes of next-generation artificial hearts be established as soon as possible.

Influence of TESG layer viscoelasticity on the imaging properties of microlenses

NASA Astrophysics Data System (ADS)

Vasiljević, Darko; Murić, Branka; Pantelić, Dejan; Panić, Bratimir

2012-05-01

Microlenses were produced by the irradiation of a layer of tot'hema and eosin sensitized gelatin (TESG) with laser light (second harmonic Nd:YAG, 532 nm). For this research, eight microlenses were written on a dog-bone-shaped TESG layer. After production, microlenses were uniaxially stretched on a tensile testing machine. Each microlens had different amounts of strain (0, 30, 60, 80, 120, 140, 180 and 240% strain). The influence of TESG layer extensibility on the imaging properties of microlenses was characterized by calculating the root mean square wavefront aberration, the modulation transfer function and the geometrical spot diagram. All microlenses had very good imaging properties and the microlens with 0% strain had diffraction-limited performance.

Next generation sequencers: methods and applications in food-borne pathogens

USDA-ARS?s Scientific Manuscript database

Next generation sequencers are able to produce millions of short sequence reads in a high-throughput, low-cost way. The emergence of these technologies has not only facilitated genome sequencing but also started to change the landscape of life sciences. This chapter will survey their methods and app...

Exploring Hitherto Uncharted Planet Territory with Lucky-imaging Microlensing Observations

NASA Astrophysics Data System (ADS)

Dominik, Martin; Jørgensen, U. G.; Hessman, F. V.; Horne, K.; Harpsøe, K.; Skottfelt, J.; MiNDSTEp Consortium

2011-09-01

Leading the agenda for pushing the planet sensitivity limit towards the mass of the Moon, we will report first results from our 2011 MiNDSTEp (Microlensing Network for the Detection of Small Terrestrial Exoplanets) lucky-imaging microlensing follow-up campaign with the Danish 1.54m at ESO La Silla. It serves as a precursor to observations with a global network comprising the LCOGT/SUPAscope, SONG, and MONET 1m-class robotic telescope networks gradually deployed from 2011 to 2014. As for observations from space, the lucky-imaging technique allows us to get around the atmospheric image blurring and to obtain a resolution near the diffraction limit. This enables high-precision photometry on considerably fainter (smaller) stars in the crowded fields towards the Galactic bulge than obtainable from ground-based surveys. Monitoring smaller source stars in turn provides sensitivity to planets with smaller masses orbiting the lens star. M.D. is supported by a Royal Society University Research Fellowship

Microlensing of an extended source by a power-law mass distribution

NASA Astrophysics Data System (ADS)

Congdon, Arthur B.; Keeton, Charles R.; Osmer, S. J.

2007-03-01

Microlensing promises to be a powerful tool for studying distant galaxies and quasars. As the data and models improve, there are systematic effects that need to be explored. Quasar continuum and broad-line regions may respond differently to microlensing due to their different sizes; to understand this effect, we study microlensing of finite sources by a mass function of stars. We find that microlensing is insensitive to the slope of the mass function but does depend on the mass range. For negative-parity images, diluting the stellar population with dark matter increases the magnification dispersion for small sources and decreases it for large sources. This implies that the quasar continuum and broad-line regions may experience very different microlensing in negative-parity lensed images. We confirm earlier conclusions that the surface brightness profile and geometry of the source have little effect on microlensing. Finally, we consider non-circular sources. We show that elliptical sources that are aligned with the direction of shear have larger magnification dispersions than sources with perpendicular alignment, an effect that becomes more prominent as the ellipticity increases. Elongated sources can lead to more rapid variability than circular sources, which raises the prospect of using microlensing to probe source shape.

Next Generation NASA Initiative for Space Geodesy

NASA Technical Reports Server (NTRS)

Merkowitz, S. M.; Desai, S.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry J. F.; Murphy, D.; Noll, C. E.;

Augmenting WFIRST Microlensing with a Ground-Based Telescope Network

NASA Astrophysics Data System (ADS)

Zhu, Wei; Gould, Andrew

2016-06-01

Augmenting the Wide Field Infrared Survey Telescope (WFIRST) microlensing campaigns with intensive observations from a ground-based network of wide-field survey telescopes would have several major advantages. First, it would enable full two-dimensional (2-D) vector microlens parallax measurements for a substantial fraction of low-mass lenses as well as planetary and binary events that show caustic crossing features. For a significant fraction of the free-floating planet (FFP) events and all caustic-crossing planetary/binary events, these 2-D parallax measurements directly lead to complete solutions (mass, distance, transverse velocity) of the lens object (or lens system). For even more events, the complementary ground-based observations will yield 1-D parallax measurements. Together with the 1-D parallaxes from WFIRST alone, they can probe the entire mass range M > M_Earth. For luminous lenses, such 1-D parallax measurements can be promoted to complete solutions (mass, distance, transverse velocity) by high-resolution imaging. This would provide crucial information not only about the hosts of planets and other lenses, but also enable a much more precise Galactic model. Other benefits of such a survey include improved understanding of binaries (particularly with low mass primaries), and sensitivity to distant ice-giant and gas-giant companions of WFIRST lenses that cannot be detected by WFIRST itself due to its restricted observing windows. Existing ground-based microlensing surveys can be employed if WFIRST is pointed at lower-extinction fields than is currently envisaged. This would come at some cost to the event rate. Therefore the benefits of improved characterization of lenses must be weighed against these costs.

Next-Generation Telemetry Workstation

NASA Technical Reports Server (NTRS)

2008-01-01

A next-generation telemetry workstation has been developed to replace the one currently used to test and control Range Safety systems. Improving upon the performance of the original system, the new telemetry workstation uses dual-channel telemetry boards for better synchronization of the two uplink telemetry streams. The new workstation also includes an Interrange Instrumentation Group/Global Positioning System (IRIG/GPS) time code receiver board for independent, local time stamping of return-link data. The next-generation system will also record and play back return-link data for postlaunch analysis.

Generation Next

ERIC Educational Resources Information Center

Hawkins, B. Denise

2010-01-01

There is a shortage of accounting professors with Ph.D.s who can prepare the next generation. To help reverse the faculty deficit, the American Institute of Certified Public Accountants (CPAs) has created the new Accounting Doctoral Scholars program by pooling more than $17 million and soliciting commitments from more than 70 of the nation's…

A Likely Detection of a Two-planet System in a Low-magnification Microlensing Event

NASA Astrophysics Data System (ADS)

Suzuki, D.; Bennett, D. P.; Udalski, A.; Bond, I. A.; Sumi, T.; Han, C.; Kim, Ho-il.; Abe, F.; Asakura, Y.; Barry, R. K.; Bhattacharya, A.; Donachie, M.; Freeman, M.; Fukui, A.; Hirao, Y.; Itow, Y.; Koshimoto, N.; Li, M. C. A.; Ling, C. H.; Masuda, K.; Matsubara, Y.; Muraki, Y.; Nagakane, M.; Onishi, K.; Oyokawa, H.; Ranc, C.; Rattenbury, N. J.; Saito, To.; Sharan, A.; Sullivan, D. J.; Tristram, P. J.; Yonehara, A.; MOA Collaboration; Poleski, R.; Mróz, P.; Skowron, J.; Szymański, M. K.; Soszyński, I.; Kozłowski, S.; Pietrukowicz, P.; Wyrzykowski, Ł.; Ulaczyk, K.; OGLE Collaboration

2018-06-01

We report on the analysis of a microlensing event, OGLE-2014-BLG-1722, that showed two distinct short-term anomalies. The best-fit model to the observed light curves shows that the two anomalies are explained with two planetary mass ratio companions to the primary lens. Although a binary-source model is also able to explain the second anomaly, it is marginally ruled out by 3.1σ. The two-planet model indicates that the first anomaly was caused by planet “b” with a mass ratio of q=({4.5}-0.6+0.7)× {10}-4 and projected separation in units of the Einstein radius, s = 0.753 ± 0.004. The second anomaly reveals planet “c” with a mass ratio of {q}2=({7.0}-1.7+2.3)× {10}-4 with Δχ 2 ∼ 170 compared to the single-planet model. Its separation has two degenerated solutions: the separation of planet c is s 2 = 0.84 ± 0.03 and 1.37 ± 0.04 for the close and wide models, respectively. Unfortunately, this event does not show clear finite-source and microlensing parallax effects; thus, we estimated the physical parameters of the lens system from Bayesian analysis. This gives the masses of planets b and c as {m}{{b}}={56}-33+51 and {m}{{c}}={85}-51+86 {M}\\oplus , respectively, and they orbit a late-type star with a mass of {M}host} ={0.40}-0.24+0.36 {M}ȯ located at {D}{{L}}={6.4}-1.8+1.3 {kpc} from us. The projected distances between the host and planets are {r}\\perp ,{{b}}=1.5+/- 0.6 {au} for planet b and {r}\\perp ,{{c}}={1.7}-0.6+0.7 {au} and {r}\\perp ,{{c}}={2.7}-1.0+1.1 {au} for the close and wide models of planet c. If the two-planet model is true, then this is the third multiple-planet system detected using the microlensing method and the first multiple-planet system detected in low-magnification events, which are dominant in the microlensing survey data. The occurrence rate of multiple cold gas giant systems is estimated using the two such detections and a simple extrapolation of the survey sensitivity of the 6 yr MOA microlensing survey combined with the

Predicting the 4th caustic crossing in Gaia16aye binary microlensing event

NASA Astrophysics Data System (ADS)

Mroz, P.; Wyrzykowski, L.; Rybicki, K.; Altavilla, G.; Bakis, V.; Bendjoya, P.; Birenbaum, G.; Blagorodnova, N.; Blanco-Cuaresma, S.; Bonanos, A.; Bozza, V.; Britavskiy, N.; Burgaz, U.; Butterley, T.; Capuozzo, P.; Carrasco, J. M.; Chruslinska, M.; Damljanovic, G.; Dennefeld, M.; Dhillon, V. S.; Dominik, M.; Esenoglu, H.; Fossey, S.; Gomboc, A.; Hallokoun, N.; Hamanowicz, A.; Hardy, L. K.; Hudec, R.; Khamitov, I.; Klencki, J.; Kolaczkowski, Z.; Kolb, U.; Leonini, S.; Leto, G.; Lewis, F.; Liakos, A.; Littlefair, S. P.; Maoz, D.; Maund, J. R.; Mikolajczyk, P.; Palaversa, L.; Pawlak, M.; Penny, M.; Piascik, A.; Reig, P.; Rhodes, L.; Russell, D.; Sanchez, R. Z.; Shappee, B.; Shvartzvald, Y.; Sitek, M.; Sniegowska, M.; Sokolovsky, K.; Steele, I.; Street, R.; Tomasella, L.; Trascinelli, L.; Wiersema, K.; Wilson, R. W.; Zharkov, I.; Zola, S.; Zubareva, A.

2016-11-01

Gaia16aye, nicknamed Ayers Rock (19:40:01.13 +30:07:53.4, J2000) is a spectacular binary microlensing event in the Northern Galactic Plane. The event has been observed by Gaia, ASAS-SN survey and a network of follow-up telescopes, coordinated by the Time Domain WP of the EC's OPTICON grant.

Stellar, remnant, planetary, and dark-object masses from astrometric microlensing

NASA Technical Reports Server (NTRS)

Boden, A.; Gould, A. P.; Bennett, D. P.; Depoy, D. L.; Gaudi, S. B.; Griest, K.; Han, C.; Paczynski, B.; Reid, I. N.

2002-01-01

With SIM, we will break the microlensing degeneracy, and allow detailed interpretation of individual microlensing events. We will thus develop a detailed census of the dark and luminous stellar population of the Galaxy.

The next generation Antarctic digital magnetic anomaly map

USGS Publications Warehouse

von Frese, R.R.B; Golynsky, A.V.; Kim, H.R.; Gaya-Piqué, L.; Thébault, E.; Chiappinii, M.; Ghidella, M.; Grunow, A.; ,

2007-01-01

S (Golynsky et al., 2001). This map synthesized over 7.1 million line-kms of survey data available up through 1999 from marine, airborne and Magsat satellite observations. Since the production of the initial map, a large number of new marine and airborne surveys and improved magnetic observations from the Ørsted and CHAMP satellite missions have become available. In addition, an improved core field model for the Antarctic has been developed to better isolate crustal anomalies in these data. The next generation compilation also will likely represent the magnetic survey observations of the region in terms of a high-resolution spherical cap harmonic model. In this paper, we review the progress and problems of developing an improved magnetic anomaly map to facilitate studies of the Antarctic crustal magnetic field

A survey of tools for variant analysis of next-generation genome sequencing data

PubMed Central

Pabinger, Stephan; Dander, Andreas; Fischer, Maria; Snajder, Rene; Sperk, Michael; Efremova, Mirjana; Krabichler, Birgit; Speicher, Michael R.; Zschocke, Johannes

2014-01-01

Recent advances in genome sequencing technologies provide unprecedented opportunities to characterize individual genomic landscapes and identify mutations relevant for diagnosis and therapy. Specifically, whole-exome sequencing using next-generation sequencing (NGS) technologies is gaining popularity in the human genetics community due to the moderate costs, manageable data amounts and straightforward interpretation of analysis results. While whole-exome and, in the near future, whole-genome sequencing are becoming commodities, data analysis still poses significant challenges and led to the development of a plethora of tools supporting specific parts of the analysis workflow or providing a complete solution. Here, we surveyed 205 tools for whole-genome/whole-exome sequencing data analysis supporting five distinct analytical steps: quality assessment, alignment, variant identification, variant annotation and visualization. We report an overview of the functionality, features and specific requirements of the individual tools. We then selected 32 programs for variant identification, variant annotation and visualization, which were subjected to hands-on evaluation using four data sets: one set of exome data from two patients with a rare disease for testing identification of germline mutations, two cancer data sets for testing variant callers for somatic mutations, copy number variations and structural variations, and one semi-synthetic data set for testing identification of copy number variations. Our comprehensive survey and evaluation of NGS tools provides a valuable guideline for human geneticists working on Mendelian disorders, complex diseases and cancers. PMID:23341494

Microlensing and Intrinsic Variability of the Broad Emission Lines of Lensed Quasars

NASA Astrophysics Data System (ADS)

Fian, C.; Guerras, Eduardo; Mediavilla, E.; Jiménez-Vicente, J.; Muñoz, J. A.; Falco, E. E.; Motta, V.; Hanslmeier, A.

2018-05-01

We study the broad emission lines in a sample of 11 gravitationally lensed quasars with at least two epochs of observation to identify intrinsic variability and to disentangle it from microlensing. To improve our statistical significance and emphasize trends, we also include 15 lens systems with single-epoch spectra. Mg II and C III] emission lines are only weakly affected by microlensing, but C IV shows strong microlensing in some cases, even for regions of the line core, presumably associated with small projected velocities. However, excluding the strongly microlensed cases, there is a strikingly good match, on average, between the red wings of the C IV and C III] profiles. Analysis of these results supports the existence of two regions in the broad-line region (BLR), one that is insensitive to microlensing (of size ≳50 lt-day and kinematics not confined to a plane) and another that shows up only when it is magnified by microlensing (of size of a few light-days, comparable to the accretion disk). Both regions can contribute in different proportions to the emission lines of different species and, within each line profile, to different velocity bins, all of which complicates detailed studies of the BLR based on microlensing size estimates. The strength of the microlensing indicates that some spectral features that make up the pseudo-continuum, such as the shelf-like feature at λ1610 or several Fe III blends, may in part arise from an inner region of the accretion disk. In the case of Fe II, microlensing is strong in some blends but not in others. This opens up interesting possibilities to study quasar accretion disk kinematics. Intrinsic variability seems to affect the same features prone to microlensing, with similar frequency and amplitude, but does not induce outstanding profile asymmetries. We measure intrinsic variability (≲20%) of the wings with respect to the cores in the C IV, C III], and Mg II lines consistent with reverberation mapping studies.

Structure formation and microlensing with axion miniclusters

NASA Astrophysics Data System (ADS)

Fairbairn, Malcolm; Marsh, David J. E.; Quevillon, Jérémie; Rozier, Simon

2018-04-01

If the symmetry breaking responsible for axion dark matter production occurs during the radiation-dominated epoch in the early Universe, then this produces large amplitude perturbations that collapse into dense objects known as axion miniclusters. The characteristic minicluster mass, M0, is set by the mass inside the horizon when axion oscillations begin. For the QCD axion M0˜10-10 M⊙, however, for an axionlike particle, M0 can approach M⊙ or higher. Using the Press-Schechter formalism we compute the mass function of halos formed by hierarchical structure formation from these seeds. We compute the concentrations and collapse times of these halos and show that they can grow to be as massive as 1 06M0. Within the halos, miniclusters likely remain tightly bound, and we compute their gravitational microlensing signal taking the fraction of axion dark matter collapsed into miniclusters, fMC, as a free parameter. A large value of fMC severely weakens constraints on axion scenarios from direct detection experiments. We take into account the non-Gaussian distribution of sizes of miniclusters and determine how this affects the number of microlensing events. We develop the tools to consider microlensing by an extended mass function of nonpointlike objects, and we use microlensing data to place the first observational constraints on fMC. This opens a new window for the potential discovery of the axion.

Identification on HST Images of Microlensed Stars from the MACHO Project

NASA Astrophysics Data System (ADS)

King, L. J.; Alcock, C.; Allsman, R. A.; Alves, D. R.; Axelrod, T. S.; Becker, A. C.; Bennett, D. P.; Cook, K. H.; Drake, A. J.; Freeman, K. C.; Griest, K.; Lehner, M. J.; Marshall, S. L.; Minniti, D.; Peterson, B. A.; Popowski, P.; Pratt, M. R.; Quinn, P. J.; Rodgers, A. W.; Stubbs, C. W.; Sutherland, W.; Tomaney, A.; Vandehei, T.; Welch, D. L.; MACHO Collaboration

1998-12-01

The MACHO collaboration has been searching for microlensing events toward the Galactic Bulge and the Magellanic Clouds. We have used the WFPC2/HST to obtain high resolution images of a number of fields centred on stars that have undergone microlensing events. Ground based optical images typically have a resolution in excess of one arcsecond, so that the microlensed star may be blended with other stars. On HST images the star is unblended. We show that microlensed stars can be identified by comparing the HST images with image subtracted ground based images. The unblended intrinsic magnitudes, lensed magnitudes and magnifications of the stars can be determined, providing invaluable constraints on lens models.

Baryonic Dark Matter: The Results from Microlensing Surveys

NASA Astrophysics Data System (ADS)

Alcock, Charles; Allsman, Robyn A.; Alves, David; Axelrod, Tim S.; Becker, Andrew C.; Bennett, David; Cook, Kem H.; Drake, Andrew J.; Freeman, Ken C.; Griest, Kim; Lehner, Matt; Marshall, Stuart; Minniti, Dante; Peterson, Bruce; Pratt, Mark; Quinn, Peter; Rodgers, Alex; Stubbs, Chris; Sutherland, Will; Tomaney, Austin; Vandehei, Thor; Welch, Doug L.

Baryonic material can exist in several dark forms: ``planets," brown dwarfs, very old degenerate dwarf stars, and neutron stars. (Black holes are frequently added to this list, even though a black hole has no baryon number.) These objects, most of which emit some light but at levels below present day detection thresholds, are collectively known as Machos. Several groups have exploited the gravitational microlens signature to search for Machos in the dark halo of the Milky Way. Over 200 microlensing events have been reported (most by the MACHO Project, which uses the Great Melbourne Telescope near this conference site), of which about 20 are toward the Magellanic Clouds. The most straightforward interpretation of the results is that Machos make up between 20% and 100% of the dark matter in the halo, and that these objects weigh about 0.5 msun. Objects of substellar mass do not comprise much of the dark matter. Many alternative interpretations of these results have been proposed. We will discuss strategies for resolving the differences among these competing explanations.

3D micro-lenses for free space intra-chip coupling in photonic-integrated circuits (Conference Presentation)

NASA Astrophysics Data System (ADS)

Thomas, Robert; Williams, Gwilym I.; Ladak, Sam; Smowton, Peter M.

2017-02-01

The integration of multiple optical elements on a common substrate to create photonic integrated circuits (PIC) has been successfully applied in: fibre-optic communications, photonic computing and optical sensing. The push towards III-Vs on silicon promises a new generation of integrated devices that combine the advantages of both integrated electronics and optics in a single substrate. III-V edge emitting laser diodes offer high efficiency and low threshold currents making them ideal candidates for the optically active elements of the next generation of PICs. Nevertheless, the highly divergent and asymmetric beam shapes intrinsic to these devices limits the efficiency with which optical elements can be free space coupled intra-chip; a capability particularly desirable for optical sensing applications e.g. [1]. Furthermore, the monolithic nature of the integrated approach prohibits the use of macroscopic lenses to improve coupling. However, with the advent of 3D direct laser writing, three dimensional lenses can now be manufactured on a microscopic-scale [2], making the use of micro-lens technology for enhanced free space coupling of integrated optical elements feasible. Here we demonstrate the first use of 3D micro-lenses to improve the coupling efficiency of monolithically integrated lasers. Fabricated from IP-dip photoresist using a Nanoscribe GmbH 3D lithography tool, the lenses are embedded directly onto a structured GaInP/AlGaInP substrate containing arrays of ridge lasers free space coupled to one another via a 200 μm air gap. We compare the coupling efficiency of these lasers with and without micro-lenses through photo-voltage and beam profile measurements and discuss optimisation of lens design.

The Next Generation Virgo Cluster Survey. XX. RedGOLD Background Galaxy Cluster Detections

NASA Astrophysics Data System (ADS)

Licitra, Rossella; Mei, Simona; Raichoor, Anand; Erben, Thomas; Hildebrandt, Hendrik; Muñoz, Roberto P.; Van Waerbeke, Ludovic; Côté, Patrick; Cuillandre, Jean-Charles; Duc, Pierre-Alain; Ferrarese, Laura; Gwyn, Stephen D. J.; Huertas-Company, Marc; Lançon, Ariane; Parroni, Carolina; Puzia, Thomas H.

2016-09-01

We build a background cluster candidate catalog from the Next Generation Virgo Cluster Survey (NGVS) using our detection algorithm RedGOLD. The NGVS covers 104 deg2 of the Virgo cluster in the {u}* ,g,r,I,z-bandpasses to a depth of g ˜ 25.7 mag (5σ). Part of the survey was not covered or has shallow observations in the r band. We build two cluster catalogs: one using all bandpasses, for the fields with deep r-band observations (˜20 deg2), and the other using four bandpasses ({u}* ,g,I,z) for the entire NGVS area. Based on our previous Canada-France-Hawaii Telescope Legacy Survey W1 studies, we estimate that both of our catalogs are ˜100% (˜70%) complete and ˜80% pure, at z ≤ 0.6 (z ≲ 1), for galaxy clusters with masses of M ≳ 1014 M ⊙. We show that when using four bandpasses, though the photometric redshift accuracy is lower, RedGOLD detects massive galaxy clusters up to z ˜ 1 with completeness and purity similar to the five-band case. This is achieved when taking into account the bias in the richness estimation, which is ˜40% lower at 0.5 ≤ z < 0.6 and ˜20% higher at 0.6 < z < 0.8, with respect to the five-band case. RedGOLD recovers all the X-ray clusters in the area with mass M 500 > 1.4 × 1014 M ⊙ and 0.08 < z < 0.5. Because of our different cluster richness limits and the NGVS depth, our catalogs reach lower masses than the published redMaPPer cluster catalog over the area, and we recover ˜90%-100% of its detections.

Reconfigurable and responsive droplet-based compound micro-lenses

PubMed Central

Nagelberg, Sara; Zarzar, Lauren D.; Nicolas, Natalie; Subramanian, Kaushikaram; Kalow, Julia A.; Sresht, Vishnu; Blankschtein, Daniel; Barbastathis, George; Kreysing, Moritz; Swager, Timothy M.; Kolle, Mathias

2017-01-01

Micro-scale optical components play a crucial role in imaging and display technology, biosensing, beam shaping, optical switching, wavefront-analysis, and device miniaturization. Herein, we demonstrate liquid compound micro-lenses with dynamically tunable focal lengths. We employ bi-phase emulsion droplets fabricated from immiscible hydrocarbon and fluorocarbon liquids to form responsive micro-lenses that can be reconfigured to focus or scatter light, form real or virtual images, and display variable focal lengths. Experimental demonstrations of dynamic refractive control are complemented by theoretical analysis and wave-optical modelling. Additionally, we provide evidence of the micro-lenses' functionality for two potential applications—integral micro-scale imaging devices and light field display technology—thereby demonstrating both the fundamental characteristics and the promising opportunities for fluid-based dynamic refractive micro-scale compound lenses. PMID:28266505

Reconfigurable and responsive droplet-based compound micro-lenses.

PubMed

Nagelberg, Sara; Zarzar, Lauren D; Nicolas, Natalie; Subramanian, Kaushikaram; Kalow, Julia A; Sresht, Vishnu; Blankschtein, Daniel; Barbastathis, George; Kreysing, Moritz; Swager, Timothy M; Kolle, Mathias

2017-03-07

Micro-scale optical components play a crucial role in imaging and display technology, biosensing, beam shaping, optical switching, wavefront-analysis, and device miniaturization. Herein, we demonstrate liquid compound micro-lenses with dynamically tunable focal lengths. We employ bi-phase emulsion droplets fabricated from immiscible hydrocarbon and fluorocarbon liquids to form responsive micro-lenses that can be reconfigured to focus or scatter light, form real or virtual images, and display variable focal lengths. Experimental demonstrations of dynamic refractive control are complemented by theoretical analysis and wave-optical modelling. Additionally, we provide evidence of the micro-lenses' functionality for two potential applications-integral micro-scale imaging devices and light field display technology-thereby demonstrating both the fundamental characteristics and the promising opportunities for fluid-based dynamic refractive micro-scale compound lenses.

Low-cost, high-precision micro-lensed optical fiber providing deep-micrometer to deep-nanometer-level light focusing.

PubMed

Wen, Sy-Bor; Sundaram, Vijay M; McBride, Daniel; Yang, Yu

2016-04-15

A new type of micro-lensed optical fiber through stacking appropriate high-refractive microspheres at designed locations with respect to the cleaved end of an optical fiber is numerically and experimentally demonstrated. This new type of micro-lensed optical fiber can be precisely constructed with low cost and high speed. Deep micrometer-scale and submicrometer-scale far-field light spots can be achieved when the optical fibers are multimode and single mode, respectively. By placing an appropriate teardrop dielectric nanoscale scatterer at the far-field spot of this new type of micro-lensed optical fiber, a deep-nanometer near-field spot can also be generated with high intensity and minimum joule heating, which is valuable in high-speed, high-resolution, and high-power nanoscale detection compared with traditional near-field optical fibers containing a significant portion of metallic material.

Application of Compressive Sensing to Gravitational Microlensing Experiments

NASA Technical Reports Server (NTRS)

Korde-Patel, Asmita; Barry, Richard K.; Mohsenin, Tinoosh

2016-01-01

Compressive Sensing is an emerging technology for data compression and simultaneous data acquisition. This is an enabling technique for significant reduction in data bandwidth, and transmission power and hence, can greatly benefit spaceflight instruments. We apply this process to detect exoplanets via gravitational microlensing. We experiment with various impact parameters that describe microlensing curves to determine the effectiveness and uncertainty caused by Compressive Sensing. Finally, we describe implications for spaceflight missions.

Photometric microlensing and stellar mass determination

NASA Astrophysics Data System (ADS)

Samadi, R.

Microlensing was suggested for stellar mass determination of nearby stars by several authors (e.g. Paczynski 1995 and Miralada-Escude 1996). There are two aspects in gravitational microlensing: photometry and astrometry. Here only the photometric aspect -i.e. magnification of a background source by a stellar lens- will be considered. The first study in this domain was done by Paczyński (1995). An attempt to investigate some observational constraints (Alard et al. 1996), takes its origin in this study. It will be shown here that blending of the source by the lens, not only induces a degeneracy which has been pointed out by Wozniak and Paczynski (1997) and can be removed by measuring the flux of the source outside the microlensing event, but also strongly reduces the photometric cross section as well as the duration of microlensing events. The expected number of events decreases strongly with blending. Blending effects can be reduced by selecting faint lens candidates. Unfortunately however, it is difficult to monitor a sufficient number of lens candidates per night, and restricting oneself to nearby and high proper motion objects would lead to a very small number of lens candidates. In the case of short duration events, the light curve must be sampled at short time intervals. When sampling daily, the condition is very strong and the expected rate of events very small. Observing from space would increase significantly the rate, but this gain is still insufficient. We conclude that the event rate will be very small and that the project does not seem to be feasible at least under current observing conditions and even in the near future.

pyLIMA : The first open source microlensing modeling software

NASA Astrophysics Data System (ADS)

Bachelet, Etienne; Street, Rachel; Bozza, Valerio

2018-01-01

Microlensing is highly sensitive to planets beyond the snowline and distributed along the line of sight towards the Galactic Bulge. The WFIRST-AFTA mission should detect about 3000 of these planets and significantly improves our knowledge of planet formation and statistics, complementing results found by transit and radial velocity methods. However, the modeling of microlensing event is challenging on different aspects leading to a highly time consuming analysis. After a quick summarize of these different challenges, I will present pyLIMA, the first open source microlensing modeling software. The aimed goal of this software are to be flexible, powerful and user friendly. This presentation will focus on various case and early results.

Brown Dwarf Microlensing (Illustration)

NASA Image and Video Library

2016-11-10

This illustration depicts a newly discovered brown dwarf, an object that weighs in somewhere between our solar system's most massive planet (Jupiter) and the least-massive-known star. This brown dwarf, dubbed OGLE-2015-BLG-1319, interests astronomers because it may fall in the "desert" of brown dwarfs. Scientists have found that, for stars roughly the mass of our sun, less than 1 percent have a brown dwarf orbiting within 3 AU (1 AU is the distance between Earth and the sun). This brown dwarf was discovered when it and its star passed between Earth and a much more distant star in our galaxy. This created a microlensing event, where the gravity of the system amplified the light of the background star over the course of several weeks. This microlensing was observed by ground-based telescopes looking for these uncommon events, and was the first to be seen by two space-based telescopes: NASA's Spitzer and Swift missions. http://photojournal.jpl.nasa.gov/catalog/PIA21076

Application of Compressive Sensing to Gravitational Microlensing Experiments

NASA Astrophysics Data System (ADS)

Korde-Patel, Asmita; Barry, Richard K.; Mohsenin, Tinoosh

2017-06-01

Compressive Sensing is an emerging technology for data compression and simultaneous data acquisition. This is an enabling technique for significant reduction in data bandwidth, and transmission power and hence, can greatly benefit space-flight instruments. We apply this process to detect exoplanets via gravitational microlensing. We experiment with various impact parameters that describe microlensing curves to determine the effectiveness and uncertainty caused by Compressive Sensing. Finally, we describe implications for space-flight missions.

Formal Verification for a Next-Generation Space Shuttle

NASA Technical Reports Server (NTRS)

Nelson, Stacy D.; Pecheur, Charles; Koga, Dennis (Technical Monitor)

2002-01-01

This paper discusses the verification and validation (V&2) of advanced software used for integrated vehicle health monitoring (IVHM), in the context of NASA's next-generation space shuttle. We survey the current VBCV practice and standards used in selected NASA projects, review applicable formal verification techniques, and discuss their integration info existing development practice and standards. We also describe two verification tools, JMPL2SMV and Livingstone PathFinder, that can be used to thoroughly verify diagnosis applications that use model-based reasoning, such as the Livingstone system.

Next Generation Internet Overview

NASA Technical Reports Server (NTRS)

desJardins, R.

1998-01-01

Various issues associated with next generation Internet are presented in viewgraph form. Specific topics include: 1) Internet architecture; 2) NASA's advanced networking; 3) Internet capability, capacity and applications; and 4) Systems engineering.

Microlensing makes lensed quasar time delays significantly time variable

NASA Astrophysics Data System (ADS)

Tie, S. S.; Kochanek, C. S.

2018-01-01

The time delays of gravitationally lensed quasars are generally believed to be unique numbers whose measurement is limited only by the quality of the light curves and the models for the contaminating contribution of gravitational microlensing to the light curves. This belief is incorrect - gravitational microlensing also produces changes in the actual time delays on the ∼day(s) light-crossing time-scale of the emission region. This is due to a combination of the inclination of the disc relative to the line of sight and the differential magnification of the temperature fluctuations producing the variability. We demonstrate this both mathematically and with direct calculations using microlensing magnification patterns. Measuring these delay fluctuations can provide a physical scale for microlensing observations, removing the need for priors on either the microlens masses or the component velocities. That time delays in lensed quasars are themselves time variable likely explains why repeated delay measurements of individual lensed quasars appear to vary by more than their estimated uncertainties. This effect is also a new important systematic problem for attempts to use time delays in lensed quasars for cosmology or to detect substructures (satellites) in lens galaxies.

Article: Next Generation Compliance

EPA Pesticide Factsheets

The article Next Generation Compliance by Cynthia Giles, Assistant Administrator for OECA was published in The Environmental Forum, Sept-Oct 2013 explains EPA's strategy on using new technologies to improve compliance with environmental laws.

Infographic: Finding Planets With Microlensing

NASA Image and Video Library

2015-04-14

This infographic explains how NASA Spitzer Space Telescope can be used in tandem with a telescope on the ground to measure the distances to planets discovered using the microlensing technique. http://photojournal.jpl.nasa.gov/catalog/PIA19332

Next Generation Inverter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Zilai; Gough, Charles

The goal of this Cooperative Agreement was the development of a Next Generation Inverter for General Motors’ electrified vehicles, including battery electric vehicles, range extended electric vehicles, plug-in hybrid electric vehicles and hybrid electric vehicles. The inverter is a critical electronics component that converts battery power (DC) to and from the electric power for the motor (AC).

Deblending Microlensing Events Using Astrometric Shifts

NASA Astrophysics Data System (ADS)

Goldberg, D. M.; Wozniak, P.; Paczynski, B.

1997-12-01

In this poster, we present the prospect that astrometric shifts can be used to identify blended microlensing events in crowded fields. Moreover, by measuring an astrometric shift, one can determine the position of the true lensed star with respect to the local field with very high precision. We first perform several simulations of microlensing searches in crowded fields and find that if we assume a dark lens, and that the lensed star obeys a power law luminosity function, n(L)~ L(-beta ) , over half the simulated events show a measurable astrometric shift. For simulations of 20000 stars on a 256x 256 Nyquist sampled CCD frame, we found that with beta =2, 58% of the events were significantly blended (F_{*}/Ftot <= 0.9), and of those, 73% had a large astrometric shift (>= 0.5 pixels). For beta =3, we found that 85% were significantly blended, and that 85% of those had a significant shift. Since we expect most blended events to show a significant shift, we look in the OGLE I database (Wozniak & Szymanski 1997), and find measurable and systematic shifts in over half the candidate microlensing events, including OGLE # 5, which was considered to be blended from photometric data.

In situ fabricated 3D micro-lenses for photonic integrated circuits.

PubMed

Thomas, R; Li, J; Ladak, Sam; Barrow, D; Smowton, P M

2018-05-14

Aspheric astigmatic polymer micro-lenses were fabricated directly onto photonic integrated circuits using two-photon lithography. We observed a 12.6 dB improvement in the free space coupling efficiency between integrated ridge laser pairs with micro-lenses to those without.

Get Ready for Generation Next.

ERIC Educational Resources Information Center

Wellner, Alison

1999-01-01

"Generation Next" are the 68 million people born between 1977 and 1994. They are the first generation that has grown up with such technologies as computers, the Internet, compact disks, and microwaves and they have more education than previous generations. They will have an effect on trainers and training methods in the workplace. (JOW)

Size-effect of oligomeric cholesteric liquid-crystal microlenses on the optical specifications.

PubMed

Bayon, Chloé; Agez, Gonzague; Mitov, Michel

2015-10-15

In cholesteric liquid-crystalline microlenses, we have studied the role of the microlens size on the focused light intensity and the focal length. We have found that the intensity is maximized by aiming a specific range for the diameter and the thickness of microlenses and that the focal length is adjusted by controlling the diameter and the annealing time of the optical film. Cholesteric microlenses may be used as wavelength-tunable directional light sources in organic soft-matter circuits.

A next generation microdensitometer?

NASA Technical Reports Server (NTRS)

Monet, D. G.

1984-01-01

Motivations for construction of a next generation microdensitometer (NGM) are presented and their effect on the NGM design is discussed. A prototype of such an engine has been constructed at KPNO. Its design and performance is reviewed.

Measuring the Microlensing Parallax from Various Space Observatories

NASA Astrophysics Data System (ADS)

Bachelet, E.; Hinse, T. C.; Street, R.

2018-05-01

A few observational methods allow the measurement of the mass and distance of the lens-star for a microlensing event. A first estimate can be obtained by measuring the microlensing parallax effect produced by either the motion of the Earth (annual parallax) or the contemporaneous observation of the lensing event from two (or more) observatories (space or terrestrial parallax) sufficiently separated from each other. Further developing ideas originally outlined by Gould as well as Mogavero & Beaulieu, we review the possibility of measuring systematically the microlensing parallax using a telescope based on the Moon surface and other space-based observing platforms, including the upcoming WFIRST space-telescope. We first generalize the Fisher matrix formulation and present results demonstrating the advantage for each observing scenario. We conclude by outlining the limitation of the Fisher matrix analysis when submitted to a practical data modeling process. By considering a lunar-based parallax observation, we find that parameter correlations introduce a significant loss in detection efficiency of the probed lunar parallax effect.

Real-Time Optimization and Control of Next-Generation Distribution

Science.gov Websites

Infrastructure | Grid Modernization | NREL Real-Time Optimization and Control of Next -Generation Distribution Infrastructure Real-Time Optimization and Control of Next-Generation Distribution Infrastructure This project develops innovative, real-time optimization and control methods for next-generation

The Next Generation Virgo Cluster Survey. XXVIII. Characterization of the Galactic White Dwarf Population

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fantin, Nicholas J.; Côté, Patrick; Gwyn, S. D. J.

We use three different techniques to identify hundreds of white dwarf (WD) candidates in the Next Generation Virgo Cluster Survey (NGVS) based on photometry from the NGVS and GUViCS, and proper motions derived from the NGVS and the Sloan Digital Sky Survey (SDSS). Photometric distances for these candidates are calculated using theoretical color–absolute magnitude relations, while effective temperatures are measured by fitting their spectral energy distributions. Disk and halo WD candidates are separated using a tangential velocity cut of 200 km s{sup −1} in a reduced proper motion diagram, which leads to a sample of six halo WD candidates. Coolingmore » ages, calculated for an assumed WD mass of 0.6 M {sub ⊙}, range between 60 Myr and 6 Gyr, although these estimates depend sensitively on the adopted mass. Luminosity functions for the disk and halo subsamples are constructed and compared to previous results from the SDSS and SuperCOSMOS survey. We compute a number density of (2.81 ± 0.52) × 10{sup −3} pc{sup −3} for the disk WD population—consistent with previous measurements. We find (7.85 ± 4.55) × 10{sup −6} pc{sup −3} for the halo, or 0.3% of the disk. Observed stellar counts are also compared to predictions made by the TRILEGAL and Besançon stellar population synthesis models. The comparison suggests that the TRILEGAL model overpredicts the total number of WDs. The WD counts predicted by the Besançon model agree with the observations, although a discrepancy arises when comparing the predicted and observed halo WD populations; the difference is likely due to the WD masses in the adopted model halo.« less

Next-generation air monitoring

EPA Science Inventory

Air pollution measurement technology is advancing rapidly towards smaller-scale and wireless devices, with a potential to significantly change the landscape of air pollution monitoring. EPA is evaluating and developing a range of next-generation air monitoring (NGAM) technologie...

The next generation

NASA Technical Reports Server (NTRS)

Yudkin, Howard

1988-01-01

The next generation of computer systems are studied by examining the processes and methodologies. The present generation is ok for small projects, but not so good for large projects. They are not good for addressing the iterative nature of requirements, resolution, and implementation. They do not address complexity issues of requirements stabilization. They do not explicitly address reuse opportunities, and they do not help with people shortages. Therefore, there is a need to define and automate improved software engineering processes. Some help may be gained by reuse and prototyping, which are two sides of the same coin. Reuse library parts are used to generate good approximations to desired solutions, i.e., prototypes. And rapid prototype composition implies use of preexistent parts, i.e., reusable parts.

Microlensing Discovery of an Earth-Mass Planet

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-04-01

What do we know about planet formation around stars that are so light that they cant fuse hydrogen in their cores? The new discovery of an Earth-mass planet orbiting what is likely a brown dwarf may help us better understand this process.Planets Around Brown Dwarfs?Comparison of the sizes of the Sun, a low-mass star, a brown dwarf, Jupiter, and Earth. [NASA/JPL-Caltech/UCB]Planets are thought to form from the material inprotoplanetary disks around their stellar hosts. But the lowest-mass end of the stellar spectrum brown dwarfs, substellar objects so light that they straddle the boundary between planet and star will have correspondingly light disks. Do brown dwarfs disks typically have enough mass to form Earth-mass planets?To answer this question, scientists have searched for planets around brown dwarfs with marginal success. Thus far, only four such planets have been found and these systems may not be typical, since they were discovered via direct imaging. To build a more representative sample, wed like to discover exoplanets around brown dwarfs via a method that doesnt rely on imaging the faint light of the system.A diagram of how planets are detected via gravitational microlensing. The detectable planet is in orbit around the foreground lens star. [NASA]Lensed Light as a GiveawayConveniently, such a method exists and its recently been used to make a major discovery! The planet OGLE-2016-BLG-1195Lb was detected as a result of a gravitational microlensing event that was observed both from the ground and from space.The discovery of a planet via microlensing occurs when the light of a distant source star is magnified by a passing foreground star hosting a planet. The light curve of the source shows a distinctive magnification signature as a result of the gravitational lensing from the foreground star, and the gravitational field of the lensing stars planet can add its own detectable blip to the curve.OGLE-2016-BLG-1195LbThe magnification curve of OGLE-2016-BLG-1195

Speeding up low-mass planetary microlensing simulations and modeling: The caustic region of influence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Penny, Matthew T., E-mail: penny@astronomy.ohio-state.edu

2014-08-01

Extensive simulations of planetary microlensing are necessary both before and after a survey is conducted: before to design and optimize the survey and after to understand its detection efficiency. The major bottleneck in such computations is the computation of light curves. However, for low-mass planets, most of these computations are wasteful, as most light curves do not contain detectable planetary signatures. In this paper, I develop a parameterization of the binary microlens that is conducive to avoiding light curve computations. I empirically find analytic expressions describing the limits of the parameter space that contain the vast majority of low-mass planetmore » detections. Through a large-scale simulation, I measure the (in)completeness of the parameterization and the speed-up it is possible to achieve. For Earth-mass planets in a wide range of orbits, it is possible to speed up simulations by a factor of ∼30-125 (depending on the survey's annual duty-cycle) at the cost of missing ∼1% of detections (which is actually a smaller loss than for the arbitrary parameter limits typically applied in microlensing simulations). The benefits of the parameterization probably outweigh the costs for planets below 100 M{sub ⊕}. For planets at the sensitivity limit of AFTA-WFIRST, simulation speed-ups of a factor ∼1000 or more are possible.« less

OGLE-2016-BLG-1469L: Microlensing Binary Composed of Brown Dwarfs

NASA Astrophysics Data System (ADS)

Han, C.; Udalski, A.; Sumi, T.; Gould, A.; Albrow, M. D.; Chung, S.-J.; Jung, Y. K.; Ryu, Y.-H.; Shin, I.-G.; Yee, J. C.; Zhu, W.; Cha, S.-M.; Kim, S.-L.; Kim, D.-J.; Lee, C.-U.; Lee, Y.; Park, B.-G.; KMTNet Collaboration; Soszyński, I.; Mróz, P.; Pietrukowicz, P.; Szymański, M. K.; Skowron, J.; Poleski, R.; Kozłowski, S.; Ulaczyk, K.; Pawlak, M.; OGLE Collaboration; Abe, F.; Asakura, Y.; Bennett, D. P.; Bond, I. A.; Bhattacharya, A.; Donachie, M.; Freeman, M.; Fukui, A.; Hirao, Y.; Itow, Y.; Koshimoto, N.; Li, M. C. A.; Ling, C. H.; Masuda, K.; Matsubara, Y.; Muraki, Y.; Nagakane, M.; Ohnishi, K.; Oyokawa, H.; Rattenbury, N. J.; Saito, To.; Sharan, A.; Sullivan, D. J.; Suzuki, D.; Tristram, P. J.; Yamada, T.; Yamada, T.; Yonehara, A.; Barry, R.; MOA Collaboration

2017-07-01

We report the discovery of a binary composed of two brown dwarfs, based on the analysis of the microlensing event OGLE-2016-BLG-1469. Thanks to the detection of both finite-source and microlens-parallax effects, we are able to measure both the masses {M}1˜ 0.05 {M}⊙ and {M}2˜ 0.01 {M}⊙ , and the distance {D}{{L}}˜ 4.5 {kpc}, as well as the projected separation {a}\\perp ˜ 0.33 au. This is the third brown-dwarf binary detected using the microlensing method, demonstrating the usefulness of microlensing in detecting field brown-dwarf binaries with separations of less than 1 au.

Overview of NASA's Next Generation Air Transportation System (NextGen) Research

NASA Technical Reports Server (NTRS)

Swenson, Harry N.

2009-01-01

This slide presentation is an overview of the research for the Next Generation Air Transportation System (NextGen). Included is a review of the current air transportation system and the challenges of air transportation research. Also included is a review of the current research highlights and significant accomplishments.

Planar waveguide microlenses for nonblocking photonic switches and optical interconnects

NASA Astrophysics Data System (ADS)

Glebov, Alexei L.; Huang, Lidu; Lee, Michael; Aoki, Shigenori; Yokouchi, Kishio

2004-09-01

Different types of planar waveguide microlenses are fabricated with PLC technologies from a variety of optical materials such as silica, photo-definable epoxy resins, and a number of other optical polymers. Hybrid microlenses are also fabricated in which the base of the lens, with a double concave gap, is formed from silica and the gap is filled with an optical polymer. The optimized lens structures provide the maximum coupling efficiencies between the input and output channels at distances up to 100 mm with a minimum channel pitch of 0.5-0.7 mm. Experimental and theoretical studies provide results on collimation and focusing properties of single and double microlenses made of silica, polymer, and silica/polymer. The evaluation of the temperature and wavelength effects on the collimation characteristics of the lenses demonstrate that the single lenses are more stable and, thus, more suitable for operations under varying conditions. Examples of the planar waveguide microlens applications are presented. In one application the microlens arrays are integrated in fast electrooptic photonic switching modules. In the other application the microlenses are embedded in the backplanes with nonblocking optical interconnects.

Microlensing observations rapid search for exoplanets: MORSE code for GPUs

NASA Astrophysics Data System (ADS)

McDougall, Alistair; Albrow, Michael D.

2016-02-01

The rapid analysis of ongoing gravitational microlensing events has been integral to the successful detection and characterization of cool planets orbiting low-mass stars in the Galaxy. In this paper, we present an implementation of search and fit techniques on graphical processing unit (GPU) hardware. The method allows for the rapid identification of candidate planetary microlensing events and their subsequent follow-up for detailed characterization.

Stellar, Remnant, Planetary, and Dark-Object Masses from Astrometric Microlensing

NASA Technical Reports Server (NTRS)

Gould, Andrew P.; Bennett, David P.; Boden, Andrew; Depoy, Darren L.; Gaudi, Scott B.; Griest, Kim; Han, Cheongho; Paczynski, Bohdan; Reid, I. Neill

2004-01-01

The primary goal of our project is to make a complete census of the stellar population of the Galaxy. We are broadening the term stellar here to include both ordinary stars and dark stars. Ordinary stars, burning their nuclear fuel and shining, can perhaps best be studied with traditional astronomical techniques, but dark stars, by which we include old brown dwarfs, black holes, old white dwarfs, neutron stars, and perhaps exotic objects such as mirror matter stars or primordial black holes, can only be studied by their gravitational effects. Traditionally, these objects have been probed in binaries, and thus selected in a way that may or may not be representative of their respective field populations. The only way to examine the field population of these stars is through microlensing, the deflection of light from a visible star in the background by an object (dark or not) in the foreground. When lensed, there are two images of the background star. Although these images cannot be resolved when the lens has a stellar mass, the lensing effect can be detected in two ways: photometrically, i.e. by measuring the magnification of the source by the lens, and astrometrically, i.e. by measuring the shift in the centroid of the two images. Photometric microlensing experiments have detected hundreds of microlensing events over the past decade. Despite its successes, photometric microlensing has so far been somewhat frustrating because these events are difficult to interpret. Almost nothing is known about the masses of individual lenses and very little is known about the statistical properties of the lenses treated as a whole, such as their average mass. Although probably over 100 of the lenses are in fact dark objects, we can't determine which they are, let alone investigate finer details such as what their masses are, and where they are in the Galaxy. With SIM, we will break the microlensing degeneracy, and allow detailed interpretation of individual microlensing events. We

Probing the gravitational Faraday rotation using quasar X-ray microlensing

PubMed Central

Chen, Bin

2015-01-01

The effect of gravitational Faraday rotation was predicted in the 1950s, but there is currently no practical method for measuring this effect. Measuring this effect is important because it will provide new evidence for correctness of general relativity, in particular, in the strong field limit. We predict that the observed degree and angle of the X-ray polarization of a cosmologically distant quasar microlensed by the random star field in a foreground galaxy or cluster lens vary rapidly and concurrently with flux during caustic-crossing events using the first simulation of quasar X-ray microlensing polarization light curves. Therefore, it is possible to detect gravitational Faraday rotation by monitoring the X-ray polarization of gravitationally microlensed quasars. Detecting this effect will also confirm the strong gravity nature of quasar X-ray emission. PMID:26574051

Probing the gravitational Faraday rotation using quasar X-ray microlensing.

PubMed

Chen, Bin

2015-11-17

The effect of gravitational Faraday rotation was predicted in the 1950s, but there is currently no practical method for measuring this effect. Measuring this effect is important because it will provide new evidence for correctness of general relativity, in particular, in the strong field limit. We predict that the observed degree and angle of the X-ray polarization of a cosmologically distant quasar microlensed by the random star field in a foreground galaxy or cluster lens vary rapidly and concurrently with flux during caustic-crossing events using the first simulation of quasar X-ray microlensing polarization light curves. Therefore, it is possible to detect gravitational Faraday rotation by monitoring the X-ray polarization of gravitationally microlensed quasars. Detecting this effect will also confirm the strong gravity nature of quasar X-ray emission.

Simulations of the Fe K α Energy Spectra from Gravitationally Microlensed Quasars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krawczynski, H.; Chartas, G., E-mail: krawcz@wustl.edu

The analysis of the Chandra X-ray observations of the gravitationally lensed quasar RX J1131−1231 revealed the detection of multiple and energy-variable spectral peaks. The spectral variability is thought to result from the microlensing of the Fe K α emission, selectively amplifying the emission from certain regions of the accretion disk with certain effective frequency shifts of the Fe K α line emission. In this paper, we combine detailed simulations of the emission of Fe K α photons from the accretion disk of a Kerr black hole with calculations of the effect of gravitational microlensing on the observed energy spectra. Themore » simulations show that microlensing can indeed produce multiply peaked energy spectra. We explore the dependence of the spectral characteristics on black hole spin, accretion disk inclination, corona height, and microlensing amplification factor and show that the measurements can be used to constrain these parameters. We find that the range of observed spectral peak energies of QSO RX J1131−1231 can only be reproduced for black hole inclinations exceeding 70° and for lamppost corona heights of less than 30 gravitational radii above the black hole. We conclude by emphasizing the scientific potential of studies of the microlensed Fe K α quasar emission and the need for more detailed modeling that explores how the results change for more realistic accretion disk and corona geometries and microlensing magnification patterns. A full analysis should furthermore model the signal-to-noise ratio of the observations and the resulting detection biases.« less

Next generation HOM-damping

DOE PAGES

Marhauser, Frank

2017-05-15

Research and development for superconducting radio-frequency cavities has made enormous progress over the last decades from the understanding of theoretical limitations to the industrial mass fabrication of cavities for large-scale particle accelerators. Key technologies remain hot topics due to continuously growing demands on cavity performance, particularly when in pursuit of high quality beams at higher beam currents or higher luminosities than currently achievable. This relates to Higher Order Mode (HOM) damping requirements. Meeting the desired beam properties implies avoiding coupled multi-bunch or beam break-up instabilities depending on the machine and beam parameters that will set the acceptable cavity impedance thresholds.more » The use of cavity HOM-dampers is crucial to absorb the wakefields, comprised by all beam-induced cavity Eigenmodes, to beam-dynamically safe levels and to reduce the heat load at cryogenic temperature. Cavity damping concepts may vary, but are principally based on coaxial and waveguide couplers as well as beam line absorbers or any combination. Next generation Energy Recovery Linacs and circular colliders call for cavities with strong HOM-damping that can exceed the state-of-the-art, while the operating mode efficiency shall not be significantly compromised concurrently. This imposes major challenges given the rather limited damping concepts. A detailed survey of established cavities is provided scrutinizing the achieved damping performance, shortcomings, and potential improvements. The scaling of the highest passband mode impedances is numerically evaluated in dependence on the number of cells for a single-cell up to a nine-cell cavity, which reveals the increased probability of trapped modes. This is followed by simulations for single-cell and five-cell cavities, which incorporate multiple damping schemes to assess the most efficient concepts. The usage and viability of on-cell dampers is elucidated for the single-cell cavity

Next generation HOM-damping

NASA Astrophysics Data System (ADS)

Marhauser, Frank

2017-06-01

Research and development for superconducting radio-frequency cavities has made enormous progress over the last decades from the understanding of theoretical limitations to the industrial mass fabrication of cavities for large-scale particle accelerators. Key technologies remain hot topics due to continuously growing demands on cavity performance, particularly when in pursuit of high quality beams at higher beam currents or higher luminosities than currently achievable. This relates to higher order mode (HOM) damping requirements. Meeting the desired beam properties implies avoiding coupled multi-bunch or beam break-up instabilities depending on the machine and beam parameters that will set the acceptable cavity impedance thresholds. The use of cavity HOM-dampers is crucial to absorb the wakefields, comprised by all beam-induced cavity Eigenmodes, to beam-dynamically safe levels and to reduce the heat load at cryogenic temperature. Cavity damping concepts may vary, but are principally based on coaxial and waveguide couplers as well as beam line absorbers or any combination. Next generation energy recovery linacs and circular colliders call for cavities with strong HOM-damping that can exceed the state-of-the-art, while the operating mode efficiency shall not be significantly compromised concurrently. This imposes major challenges given the rather limited damping concepts. A detailed survey of established cavities is provided scrutinizing the achieved damping performance, shortcomings, and potential improvements. The scaling of the highest passband mode impedances is numerically evaluated in dependence on the number of cells for a single-cell up to a nine-cell cavity, which reveals the increased probability of trapped modes. This is followed by simulations for single-cell and five-cell cavities, which incorporate multiple damping schemes to assess the most efficient concepts. The usage and viability of on-cell dampers is elucidated for the single-cell cavity since it

Development of adaptive liquid microlenses and microlens arrays

NASA Astrophysics Data System (ADS)

Berry, Shaun R.; Stewart, Jason B.; Thorsen, Todd A.; Guha, Ingrid

2013-03-01

We report on the development of sub-millimeter size adaptive liquid microlenses and microlens arrays using two immiscible liquids to form individual lenses. Microlenses and microlens arrays having aperture diameters as small as 50 microns were fabricated on a planar quartz substrate using patterned hydrophobic/hydrophilic regions. Liquid lenses were formed by a self-assembled oil dosing process that created well-defined lenses having a high fill factor. Variable focus was achieved by controlling the lens curvature through electrowetting. Greater than 70° of contact angle change was achieved with less than 20 volts, which results in a large optical power dynamic range.

Discovery of a Jupiter/Saturn analog with gravitational microlensing.

PubMed

Gaudi, B S; Bennett, D P; Udalski, A; Gould, A; Christie, G W; Maoz, D; Dong, S; McCormick, J; Szymanski, M K; Tristram, P J; Nikolaev, S; Paczynski, B; Kubiak, M; Pietrzynski, G; Soszynski, I; Szewczyk, O; Ulaczyk, K; Wyrzykowski, L; Depoy, D L; Han, C; Kaspi, S; Lee, C-U; Mallia, F; Natusch, T; Pogge, R W; Park, B-G; Abe, F; Bond, I A; Botzler, C S; Fukui, A; Hearnshaw, J B; Itow, Y; Kamiya, K; Korpela, A V; Kilmartin, P M; Lin, W; Masuda, K; Matsubara, Y; Motomura, M; Muraki, Y; Nakamura, S; Okumura, T; Ohnishi, K; Rattenbury, N J; Sako, T; Saito, To; Sato, S; Skuljan, L; Sullivan, D J; Sumi, T; Sweatman, W L; Yock, P C M; Albrow, M D; Allan, A; Beaulieu, J-P; Burgdorf, M J; Cook, K H; Coutures, C; Dominik, M; Dieters, S; Fouqué, P; Greenhill, J; Horne, K; Steele, I; Tsapras, Y; Chaboyer, B; Crocker, A; Frank, S; Macintosh, B

2008-02-15

Searches for extrasolar planets have uncovered an astonishing diversity of planetary systems, yet the frequency of solar system analogs remains unknown. The gravitational microlensing planet search method is potentially sensitive to multiple-planet systems containing analogs of all the solar system planets except Mercury. We report the detection of a multiple-planet system with microlensing. We identify two planets with masses of approximately 0.71 and approximately 0.27 times the mass of Jupiter and orbital separations of approximately 2.3 and approximately 4.6 astronomical units orbiting a primary star of mass approximately 0.50 solar mass at a distance of approximately 1.5 kiloparsecs. This system resembles a scaled version of our solar system in that the mass ratio, separation ratio, and equilibrium temperatures of the planets are similar to those of Jupiter and Saturn. These planets could not have been detected with other techniques; their discovery from only six confirmed microlensing planet detections suggests that solar system analogs may be common.

Accessing the dark exciton spin in deterministic quantum-dot microlenses

NASA Astrophysics Data System (ADS)

Heindel, Tobias; Thoma, Alexander; Schwartz, Ido; Schmidgall, Emma R.; Gantz, Liron; Cogan, Dan; Strauß, Max; Schnauber, Peter; Gschrey, Manuel; Schulze, Jan-Hindrik; Strittmatter, Andre; Rodt, Sven; Gershoni, David; Reitzenstein, Stephan

2017-12-01

The dark exciton state in semiconductor quantum dots (QDs) constitutes a long-lived solid-state qubit which has the potential to play an important role in implementations of solid-state-based quantum information architectures. In this work, we exploit deterministically fabricated QD microlenses which promise enhanced photon extraction, to optically prepare and read out the dark exciton spin and observe its coherent precession. The optical access to the dark exciton is provided via spin-blockaded metastable biexciton states acting as heralding states, which are identified by deploying polarization-sensitive spectroscopy as well as time-resolved photon cross-correlation experiments. Our experiments reveal a spin-precession period of the dark exciton of (0.82 ± 0.01) ns corresponding to a fine-structure splitting of (5.0 ± 0.7) μeV between its eigenstates |↑ ⇑ ±↓ ⇓ ⟩. By exploiting microlenses deterministically fabricated above pre-selected QDs, our work demonstrates the possibility to scale up implementations of quantum information processing schemes using the QD-confined dark exciton spin qubit, such as the generation of photonic cluster states or the realization of a solid-state-based quantum memory.

Imprints of the quasar structure in time-delay light curves: Microlensing-aided reverberation mapping

NASA Astrophysics Data System (ADS)

Sluse, D.; Tewes, M.

2014-11-01

The advent of large area photometric surveys has raised a great deal of interest in the possibility of using broadband photometric data, instead of spectra, to measure the size of the broad line region of active galactic nuclei. We describe here a new method that uses time-delay lensed quasars where one or several images are affected by microlensing due to stars in the lensing galaxy. Because microlensing decreases (or increases) the flux of the continuum compared to the broad line region, it changes the contrast between these two emission components. We show that this effect can be used to effectively disentangle the intrinsic variability of those two regions, offering the opportunity to perform reverberation mapping based on single-band photometric data. Based on simulated light curves generated using a damped random walk model of quasar variability, we show that measurement of the size of the broad line region can be achieved using this method, provided one spectrum has been obtained independently during the monitoring. This method is complementary to photometric reverberation mapping and could also be extended to multi-band data. Because the effect described above produces a variability pattern in difference light curves between pairs of lensed images that is correlated with the time-lagged continuum variability, it can potentially produce systematic errors in measurement of time delays between pairs of lensed images. Simple simulations indicate that time-delay measurement techniques that use a sufficiently flexible model for the extrinsic variability are not affected by this effect and produce accurate time delays.

Next Generation Biopharmaceuticals: Product Development.

PubMed

Mathaes, Roman; Mahler, Hanns-Christian

2018-04-11

Therapeutic proteins show a rapid market growth. The relatively young biotech industry already represents 20 % of the total global pharma market. The biotech industry environment has traditionally been fast-pasted and intellectually stimulated. Nowadays the top ten best selling drugs are dominated by monoclonal antibodies (mABs).Despite mABs being the biggest medical breakthrough in the last 25 years, technical innovation does not stand still.The goal remains to preserve the benefits of a conventional mAB (serum half-life and specificity) whilst further improving efficacy and safety and to open new and better avenues for treating patients, e.g., improving the potency of molecules, target binding, tissue penetration, tailored pharmacokinetics, and reduced adverse effects or immunogenicity.The next generation of biopharmaceuticals can pose specific chemistry, manufacturing, and control (CMC) challenges. In contrast to conventional proteins, next-generation biopharmaceuticals often require lyophilization of the final drug product to ensure storage stability over shelf-life time. In addition, next-generation biopharmaceuticals require analytical methods that cover different ways of possible degradation patterns and pathways, and product development is a long way from being straight forward. The element of "prior knowledge" does not exist equally for most novel formats compared to antibodies, and thus the assessment of critical quality attributes (CQAs) and the definition of CQA assessment criteria and specifications is difficult, especially in early-stage development.

Proceedings of the Next Generation Exploration Conference

NASA Technical Reports Server (NTRS)

Schingler, Robbie (Editor); Lynch, Kennda

2006-01-01

The Next Generation Exploration Conference (NGEC) brought together the emerging next generation of space leaders over three intensive days of collaboration and planning. The participants extended the ongoing work of national space agencies to draft a common strategic framework for lunar exploration, to include other destinations in the solar system. NGEC is the first conference to bring together emerging leaders to comment on and contribute to these activities. The majority of the three-day conference looked beyond the moon and focused on the "next destination": Asteroids, Cis-Lunar, Earth 3.0, Mars Science and Exploration, Mars Settlement and Society, and Virtual Worlds and Virtual Exploration.

OGLE-2017-BLG-0482Lb: A Microlensing Super-Earth Orbiting a Low-mass Host Star

NASA Astrophysics Data System (ADS)

Han, C.; Hirao, Y.; Udalski, A.; Lee, C.-U.; Bozza, V.; Gould, A.; and; Abe, F.; Barry, R.; Bond, I. A.; Bennett, D. P.; Bhattacharya, A.; Donachie, M.; Evans, P.; Fukui, A.; Itow, Y.; Kawasaki, K.; Koshimoto, N.; Li, M. C. A.; Ling, C. H.; Matsubara, Y.; Miyazaki, S.; Munakata, H.; Muraki, Y.; Nagakane, M.; Ohnishi, K.; Ranc, C.; Rattenbury, N.; Saito, T.; Sharan, A.; Sullivan, D. J.; Sumi, T.; Suzuki, D.; Tristram, P. J.; Yamada, T.; Yonehara, A.; The MOA Collaboration; Mróz, P.; Poleski, R.; Kozłowski, S.; Soszyński, I.; Pietrukowicz, P.; Skowron, J.; Szymański, M. K.; Ulaczyk, K.; Pawlak, M.; Rybicki, K.; Iwanek, P.; The OGLE Collaboration; Albrow, M. D.; Chung, S.-J.; Hwang, K.-H.; Jung, Y. K.; Kim, D.; Kim, W.-T.; Kim, H.-W.; Ryu, Y.-H.; Shin, I.-G.; Shvartzvald, Y.; Yee, J. C.; Zhu, W.; Cha, S.-M.; Kim, S.-L.; Kim, D.-J.; Lee, D.-J.; Lee, Y.; Park, B.-G.; Pogge, R. W.; The KMTNet Collaboration

2018-05-01

We report the discovery of a planetary system in which a super-Earth orbits a late M-dwarf host. The planetary system was found from the analysis of the microlensing event OGLE-2017-BLG-0482, wherein the planet signal appears as a short-term anomaly to the smooth lensing light curve produced by the host. Despite its weak signal and short duration, the planetary signal was firmly detected from the dense and continuous coverage by three microlensing surveys. We find a planet/host mass ratio of q ∼ 1.4 × 10‑4. We measure the microlens parallax {π }{{E}} from the long-term deviation in the observed lensing light curve, but the angular Einstein radius {θ }{{E}} cannot be measured because the source trajectory did not cross the planet-induced caustic. Using the measured event timescale and the microlens parallax, we find that the masses of the planet and the host are {M}{{p}}={9.0}-4.5+9.0 {M}\\oplus and {M}host}={0.20}-0.10+0.20 {M}ȯ , respectively, and the projected separation between them is {a}\\perp ={1.8}-0.7+0.6 au. The estimated distance to the lens is {D}{{L}}={5.8}-2.1+1.8 kpc. The discovery of the planetary system demonstrates that microlensing provides an important method to detect low-mass planets orbiting low-mass stars.

Next Generation Solar Collectors for CSP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Molnar, Attila; Charles, Ruth

The intent of “Next Generation Solar Collectors for CSP” program was to develop key technology elements for collectors in Phase 1 (Budget Period 1), design these elements in Phase 2 (Budget Period 2) and to deploy and test the final collector in Phase 3 (Budget Period 3). 3M and DOE mutually agreed to terminate the program at the end of Budget Period 1, primarily due to timeline issues. However, significant advancements were achieved in developing a next generation reflective material and panel that has the potential to significantly improve the efficiency of CSP systems.

Chromatic microlensing in HE0047-1756 and SDSS1155+6346

NASA Astrophysics Data System (ADS)

Rojas, K.; Motta, V.; Mediavilla, E.; Falco, E.; Muñoz, J. A.

2014-10-01

The gravitational lens effect occurs when the light is deflected in the presence of a gravitational field, generating multiple images or arcs. Microlensing happens when a compact object, in the lens galaxy halo, passes across a quasar lensed image. We analyzed two double systems: HE0047-1756 and SDSS1155+6346. We used spectra obtained with Magellan/IMACS (2007) and MMT/Blue-Channel (2008). The flux of emission line cores was separated from the continuum flux under them and integrated using DIPSO software. Comparing the magnitude differences in the emission line cores with the magnitude differences in the continuum under the lines (Motta et. al 2012), we found evidence of chromatic microlensing in HE0047-1756 and SDSS1155+6346. Emission line core fluxes are used to model the systems with lensmodel. SIS + γ are the best models in both cases, which are in agreement with literature. SDSS1155+6346 model shows a large shear, due to the presence of MaxBCG J178.81693+63.83446 cluster. We follow Mediavilla et al. 2011, modeling the accretion disk as a Gaussian intensity profile I(R) ∝ exp(-R^{2}/2r_{s}^{2}), with r_s(λ) ∝ λ^{p}, where r_{s} is the accretion disk size and p is the power law related to the temperature of the disk p = 1/β. We estimate the probability of r_{s} and p using the measured microlensing magnification with linear and logarithmic priors on r_{s}. We found within 1σ of uncertainty, sizes between 3 and 15 light days and temperature profiles values between 1 and 1.2. These values are in agreement with the literature and Shakura & Sunyaev (1973) prediction. We acknowledge to FONDECYT 1120741 and Centro de Astrofísica, Universidad de Valparaíso.

Fitting Photometry of Blended Microlensing Events

NASA Astrophysics Data System (ADS)

Thomas, Christian L.; Griest, Kim

2006-03-01

We reexamine the usefulness of fitting blended light-curve models to microlensing photometric data. We find agreement with previous workers (e.g., Woźniak & Paczyński) that this is a difficult proposition because of the degeneracy of blend fraction with other fit parameters. We show that follow-up observations at specific point along the light curve (peak region and wings) of high-magnification events are the most helpful in removing degeneracies. We also show that very small errors in the baseline magnitude can result in problems in measuring the blend fraction and study the importance of non-Gaussian errors in the fit results. The biases and skewness in the distribution of the recovered blend fraction is discussed. We also find a new approximation formula relating the blend fraction and the unblended fit parameters to the underlying event duration needed to estimate microlensing optical depth.

Using Evidence to Create Next Generation High Schools

ERIC Educational Resources Information Center

Office of Planning, Evaluation and Policy Development, US Department of Education, 2016

2016-01-01

Next Generation High Schools are schools that redesign the high school experience to make it more engaging and worthwhile for high school students. In order to create such Next Generation High Schools, schools, districts, and States should utilize evidence-based strategies to transform high schools in ways that engage students and help prepare…

Applications and Case Studies of the Next-Generation Sequencing Technologies in Food, Nutrition and Agriculture.

USDA-ARS?s Scientific Manuscript database

Next-generation sequencing technologies are able to produce high-throughput short sequence reads in a cost-effective fashion. The emergence of these technologies has not only facilitated genome sequencing but also changed the landscape of life sciences. Here I survey their major applications ranging...

THE NEXT GENERATION VIRGO CLUSTER SURVEY. XIX. TOMOGRAPHY OF MILKY WAY SUBSTRUCTURES IN THE NGVS FOOTPRINT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lokhorst, Deborah; Starkenburg, Else; Navarro, Julio F.

2016-03-10

The Next Generation Virgo Cluster Survey (NGVS) is a deep u*giz survey targeting the Virgo Cluster of galaxies at 16.5 Mpc. This survey provides high-quality photometry over an ∼100 deg{sup 2} region straddling the constellations of Virgo and Coma Berenices. This sightline through the Milky Way is noteworthy in that it intersects two of the most prominent substructures in the Galactic halo: the Virgo overdensity (VOD) and Sagittarius stellar stream (close to its bifurcation point). In this paper, we use deep u*gi imaging from the NGVS to perform tomography of the VOD and Sagittarius stream using main-sequence turnoff (MSTO) starsmore » as a halo tracer population. The VOD, whose centroid is known to lie at somewhat lower declinations (α ∼ 190°, δ ∼ −5°) than is covered by the NGVS, is nevertheless clearly detected in the NGVS footprint at distances between ∼8 and 25 kpc. By contrast, the Sagittarius stream is found to slice directly across the NGVS field at distances between 25 and 40 kpc, with a density maximum at ≃35 kpc. No evidence is found for new substructures beyond the Sagittarius stream, at least out to a distance of ∼90 kpc—the largest distance to which we can reliably trace the halo using MSTO stars. We find clear evidence for a distance gradient in the Sagittarius stream across the ∼30° of sky covered by the NGVS and its flanking fields. We compare our distance measurements along the stream with those predicted by leading stream models.« less

Requirements for Next Generation Comprehensive Analysis of Rotorcraft

NASA Technical Reports Server (NTRS)

Johnson, Wayne; Data, Anubhav

2008-01-01

The unique demands of rotorcraft aeromechanics analysis have led to the development of software tools that are described as comprehensive analyses. The next generation of rotorcraft comprehensive analyses will be driven and enabled by the tremendous capabilities of high performance computing, particularly modular and scaleable software executed on multiple cores. Development of a comprehensive analysis based on high performance computing both demands and permits a new analysis architecture. This paper describes a vision of the requirements for this next generation of comprehensive analyses of rotorcraft. The requirements are described and substantiated for what must be included and justification provided for what should be excluded. With this guide, a path to the next generation code can be found.

OGLE-2016-BLG-0263Lb: Microlensing Detection of a Very Low-mass Binary Companion through a Repeating Event Channel

NASA Astrophysics Data System (ADS)

Han, C.; Udalski, A.; Gould, A.; Bond, I. A.; and; Albrow, M. D.; Chung, S.-J.; Jung, Y. K.; Ryu, Y.-H.; Shin, I.-G.; Yee, J. C.; Zhu, W.; Cha, S.-M.; Kim, S.-L.; Kim, D.-J.; Lee, C.-U.; Lee, Y.; Park, B.-G.; KMTNet Collaboration; Skowron, J.; Mróz, P.; Pietrukowicz, P.; Kozłowski, S.; Poleski, R.; Szymański, M. K.; Soszyński, I.; Ulaczyk, K.; Pawlak, M.; OGLE Collaboration; Abe, F.; Asakura, Y.; Barry, R.; Bennett, D. P.; Bhattacharya, A.; Donachie, M.; Evans, P.; Fukui, A.; Hirao, Y.; Itow, Y.; Koshimoto, N.; Li, M. C. A.; Ling, C. H.; Masuda, K.; Matsubara, Y.; Muraki, Y.; Nagakane, M.; Ohnishi, K.; Ranc, C.; Rattenbury, N. J.; Saito, To.; Sharan, A.; Sullivan, D. J.; Sumi, T.; Suzuki, D.; Tristram, P. J.; Yamada, T.; Yamada, T.; Yonehara, A.; The MOA Collaboration

2017-10-01

We report the discovery of a planet-mass companion to the microlens OGLE-2016-BLG-0263L. Unlike most low-mass companions that were detected through perturbations to the smooth and symmetric light curves produced by the primary, the companion was discovered through the channel of a repeating event, in which the companion itself produced its own single-mass light curve after the event produced by the primary had ended. Thanks to the continuous coverage of the second peak by high-cadence surveys, the possibility of the repeating nature due to source binarity is excluded with a 96% confidence level. The mass of the companion estimated by a Bayesian analysis is {M}{{p}}={4.1}-2.5+6.5 {M}{{J}}. The projected primary-companion separation is {a}\\perp ={6.5}-1.9+1.3 au. The ratio of the separation to the snow-line distance of {a}\\perp /{a}{sl}˜ 15.4 corresponds to the region beyond Neptune, the outermost planet of the solar system. We discuss the importance of high-cadence surveys in expanding the range of microlensing detections of low-mass companions and future space-based microlensing surveys.

MICROLENSING OF QUASAR BROAD EMISSION LINES: CONSTRAINTS ON BROAD LINE REGION SIZE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guerras, E.; Mediavilla, E.; Jimenez-Vicente, J.

2013-02-20

We measure the differential microlensing of the broad emission lines between 18 quasar image pairs in 16 gravitational lenses. We find that the broad emission lines are in general weakly microlensed. The results show, at a modest level of confidence (1.8{sigma}), that high ionization lines such as C IV are more strongly microlensed than low ionization lines such as H{beta}, indicating that the high ionization line emission regions are more compact. If we statistically model the distribution of microlensing magnifications, we obtain estimates for the broad line region size of r{sub s} = 24{sup +22} {sub -15} and r{sub s}more » = 55{sup +150} {sub -35} lt-day (90% confidence) for the high and low ionization lines, respectively. When the samples are divided into higher and lower luminosity quasars, we find that the line emission regions of more luminous quasars are larger, with a slope consistent with the expected scaling from photoionization models. Our estimates also agree well with the results from local reveberation mapping studies.« less

Simulator for Microlens Planet Surveys

NASA Astrophysics Data System (ADS)

Ipatov, Sergei I.; Horne, Keith; Alsubai, Khalid A.; Bramich, Daniel M.; Dominik, Martin; Hundertmark, Markus P. G.; Liebig, Christine; Snodgrass, Colin D. B.; Street, Rachel A.; Tsapras, Yiannis

2014-04-01

We summarize the status of a computer simulator for microlens planet surveys. The simulator generates synthetic light curves of microlensing events observed with specified networks of telescopes over specified periods of time. Particular attention is paid to models for sky brightness and seeing, calibrated by fitting to data from the OGLE survey and RoboNet observations in 2011. Time intervals during which events are observable are identified by accounting for positions of the Sun and the Moon, and other restrictions on telescope pointing. Simulated observations are then generated for an algorithm that adjusts target priorities in real time with the aim of maximizing planet detection zone area summed over all the available events. The exoplanet detection capability of observations was compared for several telescopes.

The OGLE view of microlensing towards the Magellanic Clouds - II. OGLE-II Small Magellanic Cloud data

NASA Astrophysics Data System (ADS)

Wyrzykowski, Ł.; Kozłowski, S.; Skowron, J.; Belokurov, V.; Smith, M. C.; Udalski, A.; Szymański, M. K.; Kubiak, M.; Pietrzyński, G.; Soszyński, I.; Szewczyk, O.

2010-09-01

The primary goal of this paper is to provide evidence that can prove true or false the hypothesis that dark matter in the Galactic halo can clump into stellar-mass compact objects. If such objects exist, they would act as lenses to external sources in the Magellanic Clouds, giving rise to an observable effect of microlensing. We present the results of our search for such events, based on data from the second phase of the OGLE survey (1996-2000) towards the Small Magellanic Cloud (SMC). The data set we used comprises 2.1 million monitored sources distributed over an area of 2.4deg2. We found only one microlensing event candidate, however its poor-quality light curve limited our discussion of the exact distance to the lensing object. Given a single event, taking blending (crowding of stars) into account for the detection-efficiency simulations and deriving the Hubble Space Telescope (HST)-corrected number of monitored stars, the microlensing optical depth is τ = (1.55 +/- 1.55) × 10-7. This result is consistent with the expected SMC self-lensing signal, with no need to introduce dark matter microlenses. Rejecting the unconvincing event leads to an upper limit on the fraction of dark matter in the form of massive compact halo objects (MACHOs) of f < 20 per cent for deflector masses around 0.4Msolar and f < 11 per cent for masses between 0.003 and 0.2Msolar (95 per cent confidence limit). Our result indicates that the Milky Way's dark matter is unlikely to be clumpy and to form compact objects in the subsolar-mass range. Based on observations obtained with the 1.3-m Warsaw Telescope at the Las Campanas Observatory of the Carnegie Institution of Washington. E-mail: wyrzykow@ast.cam.ac.uk ‡ Name pronunciation: Woocash Vizhikovsky

Spectroscopic Characterisation of Microlensing Events: Towards a New Interpretation of OGLE-2011-BLG-0417

NASA Technical Reports Server (NTRS)

Santerne, A.; Beaulieu, J.-P.; Rojas Ayala, B.; Boisse, I.; Schlawin, E.; Almenara, J.-M.; Batista, V.; Bennett, D.; Diaz, R. F.; Figueira, P.;

The NASA Next Generation Stirling Technology Program Overview

NASA Astrophysics Data System (ADS)

Schreiber, J. G.; Shaltens, R. K.; Wong, W. A.

2005-12-01

NASAs Science Mission Directorate is developing the next generation Stirling technology for future Radioisotope Power Systems (RPS) for surface and deep space missions. The next generation Stirling convertor is one of two advanced power conversion technologies currently being developed for future NASA missions, and is capable of operating for both planetary atmospheres and deep space environments. The Stirling convertor (free-piston engine integrated with a linear alternator) produces about 90 We(ac) and has a specific power of about 90 We/kg. Operating conditions of Thot at 850 degree C and Trej at 90 degree C results in the Stirling convertor estimated efficiency of about 40 per cent. Using the next generation Stirling convertor in future RPS, the "system" specific power is estimated at 8 We/kg. The design lifetime is three years on the surface of Mars and fourteen years in deep space missions. Electrical power of about 160 We (BOM) is produced by two (2) free-piston Stirling convertors heated by two (2) General Purpose Heat Source (GPHS) modules. This development is being performed by Sunpower, Athens, OH with Pratt & Whitney, Rocketdyne, Canoga Park, CA under contract to Glenn Research Center (GRC), Cleveland, Ohio. GRC is guiding the independent testing and technology development for the next generation Stirling generator.

Rhamnolipids--next generation surfactants?

PubMed

Müller, Markus Michael; Kügler, Johannes H; Henkel, Marius; Gerlitzki, Melanie; Hörmann, Barbara; Pöhnlein, Martin; Syldatk, Christoph; Hausmann, Rudolf

2012-12-31

The demand for bio-based processes and materials in the petrochemical industry has significantly increased during the last decade because of the expected running out of petroleum. This trend can be ascribed to three main causes: (1) the increased use of renewable resources for chemical synthesis of already established product classes, (2) the replacement of chemical synthesis of already established product classes by new biotechnological processes based on renewable resources, and (3) the biotechnological production of new molecules with new features or better performances than already established comparable chemically synthesized products. All three approaches are currently being pursued for surfactant production. Biosurfactants are a very promising and interesting substance class because they are based on renewable resources, sustainable, and biologically degradable. Alkyl polyglycosides are chemically synthesized biosurfactants established on the surfactant market. The first microbiological biosurfactants on the market were sophorolipids. Of all currently known biosurfactants, rhamnolipids have the highest potential for becoming the next generation of biosurfactants introduced on the market. Although the metabolic pathways and genetic regulation of biosynthesis are known qualitatively, the quantitative understanding relevant for bioreactor cultivation is still missing. Additionally, high product titers have been exclusively described with vegetable oil as sole carbon source in combination with Pseudomonas aeruginosa strains. Competitive productivity is still out of reach for heterologous hosts or non-pathogenic natural producer strains. Thus, on the one hand there is a need to gain a deeper understanding of the regulation of rhamnolipid production on process and cellular level during bioreactor cultivations. On the other hand, there is a need for metabolizable renewable substrates, which do not compete with food and feed. A sustainable bioeconomy approach should

Physical Configuration of the Next Generation Home Network

NASA Astrophysics Data System (ADS)

Terada, Shohei; Kakishima, Yu; Hanawa, Dai; Oguchi, Kimio

The number of broadband users is rapidly increasing worldwide. Japan already has over 10 million FTTH users. Another trend is the rapid digitalization of home electrical equipment e. g. digital cameras and hard disc recorders. These trends will encourage the emergence of the next generation home network. In this paper, we introduce the next generation home network image and describe the five domains into which home devices can be classified. We then clarify the optimum medium with which to configure the network given the requirements imposed by the home environment. Wiring cable lengths for three network topologies are calculated. The results gained from the next generation home network implemented on the first phase testbed are shown. Finally, our conclusions are given.

Microlensing for extrasolar planets : improving the photometry

NASA Astrophysics Data System (ADS)

Bajek, David J.

2013-08-01

Gravitational Microlensing, as a technique for detecting Extrasolar Planets, is recognised for its potential in discovering small-mass planets similar to Earth, at a distance of a few Astronomical Units from their host stars. However, analysing the data from microlensing events (which statistically rarely reveal planets) is complex and requires continued and intensive use of various networks of telescopes working together in order to observe the phenomenon. As such the techniques are constantly being developed and refined; this project outlines some steps of the careful analysis required to model an event and ensure the best quality data is used in the fitting. A quantitative investigation into increasing the quality of the original photometric data available from any microlensing event demonstrates that 'lucky imaging' can lead to a marked improvement in the signal to noise ratio of images over standard imaging techniques, which could result in more accurate models and thus the calculation of more accurate planetary parameters. In addition, a simulation illustrating the effects of atmospheric turbulence on exposures was created, and expanded upon to give an approximation of the lucky imaging technique. This further demonstrated the advantages of lucky images which are shown to potentially approach the quality of those expected from diffraction limited photometry. The simulation may be further developed for potential future use as a 'theoretical lucky imager' in our research group, capable of producing and analysing synthetic exposures through customisable conditions.

Next Generation Spacecraft, Crew Exploration Vehicle

NASA Technical Reports Server (NTRS)

2004-01-01

This special bibliography includes research on reusable launch vehicles, aerospace planes, shuttle replacement, crew/cargo transfer vehicle, related X-craft, orbital space plane, and next generation launch technology.

Compact CFB: The next generation CFB boiler

DOE Office of Scientific and Technical Information (OSTI.GOV)

Utt, J.

1996-12-31

The next generation of compact circulating fluidized bed (CFB) boilers is described in outline form. The following topics are discussed: compact CFB = pyroflow + compact separator; compact CFB; compact separator is a breakthrough design; advantages of CFB; new design with substantial development history; KUHMO: successful demo unit; KUHMO: good performance over load range with low emissions; KOKKOLA: first commercial unit and emissions; KOKKOLA: first commercial unit and emissions; compact CFB installations; next generation CFB boiler; grid nozzle upgrades; cast segmented vortex finders; vortex finder installation; ceramic anchors; pre-cast vertical bullnose; refractory upgrades; and wet gunning.

An analytic treatment of gravitational microlensing for sources of finite size at large optical depths

NASA Technical Reports Server (NTRS)

Deguchi, Shuji; Watson, William D.

1988-01-01

Statistical methods are developed for gravitational lensing in order to obtain analytic expressions for the average surface brightness that include the effects of microlensing by stellar (or other compact) masses within the lensing galaxy. The primary advance here is in utilizing a Markoff technique to obtain expressions that are valid for sources of finite size when the surface density of mass in the lensing galaxy is large. The finite size of the source is probably the key consideration for the occurrence of microlensing by individual stars. For the intensity from a particular location, the parameter which governs the importance of microlensing is determined. Statistical methods are also formulated to assess the time variation of the surface brightness due to the random motion of the masses that cause the microlensing.

Chalcogenide glass microlenses by inkjet printing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanchez, Eric A.; Waldmann, Maike; Arnold, Craig B.

We demonstrate micrometer scale mid-IR lenses for integrated optics, using solution-based inkjet printing techniques and subsequent processing. Arsenic sulfide spherical microlenses with diameters of 10-350 {mu}m and focal lengths of 10-700 {mu}m have been fabricated. The baking conditions can be used to tune the precise focal length.

Next generation vaccines.

PubMed

Riedmann, Eva M

2011-07-01

In February this year, about 100 delegates gathered for three days in Vienna (Austria) for the Next Generation Vaccines conference. The meeting held in the Vienna Hilton Hotel from 23rd-25th February 2011 had a strong focus on biotech and industry. The conference organizer Jacob Fleming managed to put together a versatile program ranging from the future generation of vaccines to manufacturing, vaccine distribution and delivery, to regulatory and public health issues. Carefully selected top industry experts presented first-hand experience and shared solutions for overcoming the latest challenges in the field of vaccinology. The program also included several case study presentations on novel vaccine candidates in different stages of development. An interactive pre-conference workshop as well as interactive panel discussions during the meeting allowed all delegates to gain new knowledge and become involved in lively discussions on timely, interesting and sometimes controversial topics related to vaccines.

Can Jupiters be found by monitoring Galactic bulge microlensing events from northern sites?

NASA Astrophysics Data System (ADS)

Tsapras, Yiannis; Street, Rachel A.; Horne, Keith; Penny, Alan; Clarke, Fraser; Deeg, Hans; Garzon, Francisco; Kemp, Simon; Zapatero Osorio, Maria Rosa; Oscoz, Alejandro Abad; Sanchez, Santiago Madruga; Eiroa, Carlos; Mora, Alcione; Alberdi, Antxon; Collier Cameron, Andrew; Davies, John K.; Ferlet, Roger; Grady, Carol; Harris, Allan W.; Palacios, Javier; Quirrenbach, Andreas; Rauer, Heike; Schneider, Jean; de Winter, Dolf; Merin, Bruno; Solano, Enrique

2001-08-01

In 1998 the EXPORT team monitored microlensing event light curves using a charge-coupled device (CCD) camera on the IACQ4 0.8-m telescope on Tenerife to evaluate the prospect of using northern telescopes to find microlens anomalies that reveal planets orbiting the lens stars. The high airmass and more limited time available for observations of Galactic bulge sources make a northern site less favourable for microlensing planet searches. However, there are potentially a large number of northern 1-m class telescopes that could devote a few hours per night to monitor ongoing microlensing events. Our IAC observations indicate that accuracies sufficient to detect planets can be achieved despite the higher airmass.

Survey of Volumetric Grid Generators

NASA Technical Reports Server (NTRS)

Woo, Alex; Volakis, John; Hulbert, Greg; Case, Jeff; Presley, Leroy L. (Technical Monitor)

1994-01-01

This document is the result of an Internet Survey of Volumetric grid generators. As such we have included information from only the responses which were sent to us. After the initial publication and posting of this survey, we would encourage authors and users of grid generators to send further information. Here is the initial query posted to SIGGRID@nas and the USENET group sci.physics.computational.fluid-dynamics. Date: Sun, 30 Jan 94 11:37:52 -0800 From: woo (Alex Woo x6010 227-6 rm 315) Subject: Info Sought for Survey of Grid Generators I am collecting information and reviews of both government sponsored and commercial mesh generators for large scientific calculations, both block structured and unstructured. If you send me a review of a mesh generator, please indicate its availability and cost. If you are a commercial concern with information on a product, please also include references for possible reviewers. Please email to woo@ra-next.arc.nasa.gov. I will post a summary and probably write a short note for the IEEE Antennas and Propagation Magazine. Alex Woo, MS 227-6 woo@ames.arc.nasa.gov NASA Ames Research Center NASAMAIL ACWOO Moffett Field, CA 94035-1000 SPANET 24582::W00 (415) 604-6010 (FAX) 604-4357 fhplabs,decwrl,uunet)!ames!woo Disclaimer: These are not official statements of NASA or EMCC. We did not include all the submitted text here. Instead we have created a database entry in the freely available and widely used BIBTeX format which has an Uniform Resource Locator (URL) field pointing to more details. The BIBTeX database is modeled after those available from the BIBNET project at University of Utah.

The Next Generation Science Standards

ERIC Educational Resources Information Center

Pruitt, Stephen L.

2015-01-01

The Next Generation Science Standards (NGSS Lead States 2013) were released almost two years ago. Work tied to the NGSS, their adoption, and implementation continues to move forward around the country. Stephen L. Pruitt, senior vice president, science, at Achieve, an independent, nonpartisan, nonprofit education reform organization that was a lead…

Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.

PubMed

Shah, Dhaval K

2015-10-01

Increasingly sophisticated protein engineering efforts have been undertaken lately to generate protein therapeutics with desired properties. This has resulted in the discovery of the next generation of protein therapeutics, which include: engineered antibodies, immunoconjugates, bi/multi-specific proteins, antibody mimetic novel scaffolds, and engineered ligands/receptors. These novel protein therapeutics possess unique physicochemical properties and act via a unique mechanism-of-action, which collectively makes their pharmacokinetics (PK) and pharmacodynamics (PD) different than other established biological molecules. Consequently, in order to support the discovery and development of these next generation molecules, it becomes important to understand the determinants controlling their PK/PD. This review discusses the determinants that a PK/PD scientist should consider during the design and development of next generation protein therapeutics. In addition, the role of systems PK/PD models in enabling rational development of the next generation protein therapeutics is emphasized.

Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics

PubMed Central

Shah, Dhaval K.

2015-01-01

Increasingly sophisticated protein engineering efforts have been undertaken lately to generate protein therapeutics with desired properties. This has resulted in the discovery of the next generation of protein therapeutics, which include: engineered antibodies, immunoconjugates, bi/multi-specific proteins, antibody mimetic novel scaffolds, and engineered ligands/receptors. These novel protein therapeutics possess unique physicochemical properties and act via a unique mechanism-of-action, which collectively makes their pharmacokinetics (PK) and pharmacodynamics (PD) different than other established biological molecules. Consequently, in order to support the discovery and development of these next generation molecules, it becomes important to understand the determinants controlling their PK/PD. This review discusses the determinants that a PK/PD scientist should consider during the design and development of next generation protein therapeutics. In addition, the role of systems PK/PD models in enabling rational development of the next generation protein therapeutics is emphasized. PMID:26373957

Sharpening the tools of gravitational microlensing

NASA Astrophysics Data System (ADS)

Poindexter, Shawn D.

We attempt to identify all microlensing parallax events for which the parallax fit improves Deltachi2 > 100 relative to a standard microlensing model. We outline a procedure to identify three types of discrete degeneracies (including a new one that we dub the "ecliptic degeneracy") and find many new degenerate solutions in 16 previously published and 6 unpublished events. Only four events have one unique solution and the other 18 events have a total of 44 solutions. Our sample includes three previously identified black-hole (BH) candidates. We consider the newly discovered degenerate solutions and determine the relative likelihood that each of these is a BH. We find the lens of event MACHO-99-BLG-22 is a strong BH candidate (78%), event MACHO-96-BLG-5 is a marginal BH candidate (37%), and MACHO-98-BLG-6 is a weak BH candidate (2.2%). The lens of event OGLE-2003-BLG-84 may be a Jupiter-mass free-floating planet candidate based on a weak 3sigma detection of finite-source effects. We find that event MACHO-179-A is a brown dwarf candidate within ˜100 pc of the Sun, mostly due to its very small projected Einstein radius, r˜E = 0.23 +/- 0.05 AU. As expected, these microlensing parallax events are biased toward lenses that are heavier and closer than average. These events were examined for xallarap (or binary-source motion), which can mimic parallax. We find that 23% of these events are strongly affected by xallarap. The mid-IR flux ratios FA/F B = 2.84 +/- 0.06 of the two images of the gravitationally lensed quasar HE 1104--1805 show no wavelength dependence to within 3% across 3.6--8.0 mum, no time dependence over 6 months and agree with the broad emission line flux ratios. This indicates that the mid-IR emission likely comes from scales large enough to be little affected by microlensing and that there is little differential extinction between the images. We measure a revised time-delay between these two images of 152.2+2.8-3.0 (1sigma) days from R and V-band data

THE NEXT GENERATION SAFEGUARDS PROFESSIONAL NETWORK: PROGRESS AND NEXT STEPS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhernosek, Alena V; Lynch, Patrick D; Scholz, Melissa A

2011-01-01

President Obama has repeatedly stated that the United States must ensure that the international safeguards regime, as embodied by the International Atomic Energy Agency (IAEA), has 'the authority, information, people, and technology it needs to do its job.' The U.S. Department of Energy (DOE) National Nuclear Security Administration (NNSA) works to implement the President's vision through the Next Generation Safeguards Initiative (NGSI), a program to revitalize the U.S. DOE national laboratories safeguards technology and human capital base so that the United States can more effectively support the IAEA and ensure that it meets current and emerging challenges to the internationalmore » safeguards system. In 2009, in response to the human capital development goals of NGSI, young safeguards professionals within the Global Nuclear Security Technology Division at Oak Ridge National Laboratory launched the Next Generation Safeguards Professional Network (NGSPN). The purpose of this initiative is to establish working relationships and to foster collaboration and communication among the next generation of safeguards leaders. The NGSPN is an organization for, and of, young professionals pursuing careers in nuclear safeguards and nonproliferation - as well as mid-career professionals new to the field - whether working within the U.S. DOE national laboratory complex, U.S. government agencies, academia, or industry or at the IAEA. The NGSPN is actively supported by the NNSA, boasts more than 70 members, maintains a website and newsletter, and has held two national meetings as well as an NGSPN session and panel at the July 2010 Institute of Nuclear Material Management Annual Meeting. This paper discusses the network; its significance, goals and objectives; developments and progress to date; and future plans.« less

Gravitational lens system SDSS J1339+1310: microlensing factory and time delay

NASA Astrophysics Data System (ADS)

Goicoechea, L. J.; Shalyapin, V. N.

2016-12-01

We spectroscopically re-observed the gravitational lens system SDSS J1339+1310 using OSIRIS on the GTC. We also monitored the r-band variability of the two quasar images (A and B) with the LT over 143 epochs in the period 2009-2016. These new data in both the wavelength and time domains have confirmed that the system is an unusual microlensing factory. The C iv emission line is remarkably microlensed, since the microlensing magnification of B relative to that for A, μBA, reaches a value of 1.4 ( 0.4 mag) for its core. Moreover, the B image shows a red wing enhancement of C iv flux (relative to A), and μBA = 2 (0.75 mag) for the C iv broad-line emission. Regarding the nuclear continuum, we find a chromatic behaviour of μBA, which roughly varies from 5 (1.75 mag) at 7000 Å to 6 (1.95 mag) at 4000 Å. We also detect significant microlensing variability in the r band, and this includes a number of microlensing events on timescales of 50-100 d. Fortunately, the presence of an intrinsic 0.7 mag dip in the light curves of A and B, permitted us to measure the time delay between both quasar images. This delay is ΔtAB = 47 d (1σ confidence interval; A is leading), in good agreement with predictions of lens models. Tables 1-3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/596/A77

Next generation biofuel engineering in prokaryotes

PubMed Central

Gronenberg, Luisa S.; Marcheschi, Ryan J.; Liao, James C.

2014-01-01

Next-generation biofuels must be compatible with current transportation infrastructure and be derived from environmentally sustainable resources that do not compete with food crops. Many bacterial species have unique properties advantageous to the production of such next-generation fuels. However, no single species possesses all characteristics necessary to make high quantities of fuels from plant waste or CO2. Species containing a subset of the desired characteristics are used as starting points for engineering organisms with all desired attributes. Metabolic engineering of model organisms has yielded high titer production of advanced fuels, including alcohols, isoprenoids and fatty acid derivatives. Technical developments now allow engineering of native fuel producers, as well as lignocellulolytic and autotrophic bacteria, for the production of biofuels. Continued research on multiple fronts is required to engineer organisms for truly sustainable and economical biofuel production. PMID:23623045

Ground-based Parallax Confirmed by Spitzer: Binary Microlensing Event MOA-2015-BLG-020

NASA Astrophysics Data System (ADS)

Wang, Tianshu; Zhu, Wei; Mao, Shude; Bond, I. A.; Gould, A.; Udalski, A.; Sumi, T.; Bozza, V.; Ranc, C.; Cassan, A.; Yee, J. C.; Han, C.; Abe, F.; Asakura, Y.; Barry, R.; Bennett, D. P.; Bhattacharya, A.; Donachie, M.; Evans, P.; Fukui, A.; Hirao, Y.; Itow, Y.; Kawasaki, K.; Koshimoto, N.; Li, M. C. A.; Ling, C. H.; Masuda, K.; Matsubara, Y.; Miyazaki, S.; Muraki, Y.; Nagakane, M.; Ohnishi, K.; Rattenbury, N.; Saito, To.; Sharan, A.; Shibai, H.; Sullivan, D. J.; Suzuki, D.; Tristram, P. J.; Yamada, T.; Yonehara, A.; MOA Collaboration; KozŁowski, S.; Mróz, P.; Pawlak, M.; Pietrukowicz, P.; Poleski, R.; Skowron, J.; Soszyński, I.; Szymański, M. K.; Ulaczyk, K.; OGLE Collaboration; Beichman, C.; Bryden, G.; Calchi Novati, S.; Carey, S.; Fausnaugh, M.; Gaudi, B. S.; Henderson, C. B.; Shvartzvald, Y.; Wibking, B.; Spitzer Team; Albrow, M. D.; Chung, S.-J.; Hwang, K.-H.; Jung, Y. K.; Ryu, Y.-H.; Shin, I.-G.; Cha, S.-M.; Kim, D.-J.; Kim, H.-W.; Kim, S.-L.; Lee, C.-U.; Lee, Y.; Park, B.-G.; Pogge, R. W.; KMTNet Collaboration; Street, R. A.; Tsapras, Y.; Hundertmark, M.; Bachelet, E.; Dominik, M.; Horne, K.; Figuera Jaimes, R.; Wambsganss, J.; Bramich, D. M.; Schmidt, R.; Snodgrass, C.; Steele, I. A.; Menzies, J.; RoboNet Collaboration

2017-08-01

We present the analysis of the binary gravitational microlensing event MOA-2015-BLG-020. The event has a fairly long timescale (˜63 days) and thus the light curve deviates significantly from the lensing model that is based on the rectilinear lens-source relative motion. This enables us to measure the microlensing parallax through the annual parallax effect. The microlensing parallax parameters constrained by the ground-based data are confirmed by the Spitzer observations through the satellite parallax method. By additionally measuring the angular Einstein radius from the analysis of the resolved caustic crossing, the physical parameters of the lens are determined. It is found that the binary lens is composed of two dwarf stars with masses {M}1=0.606+/- 0.028 {M}⊙ and {M}2=0.125 +/- 0.006 {M}⊙ in the Galactic disk. Assuming that the source star is at the same distance as the bulge red clump stars, we find the lens is at a distance {D}L=2.44+/- 0.10 {kpc}. We also provide a summary and short discussion of all of the published microlensing events in which the annual parallax effect is confirmed by other independent observations.

The Chandra Deep Wide-Field Survey: Completing the new generation of Chandra extragalactic surveys

NASA Astrophysics Data System (ADS)

Hickox, Ryan

2016-09-01

Chandra X-ray surveys have revolutionized our view of the growth of black holes across cosmic time. Recently, fundamental questions have emerged about the connection of AGN to their host large scale structures that clearly demand a wide, deep survey over a large area, comparable to the recent extensive Chandra surveys in smaller fields. We propose the Chandra Deep Wide-Field Survey (CDWFS) covering the central 6 sq. deg in the Bootes field, totaling 1.025 Ms (building on 550 ks from the HRC GTO program). CDWFS will efficiently probe a large cosmic volume, allowing us to carry out accurate new investigations of the connections between black holes and their large-scale structures, and will complete the next generation surveys that comprise a key part of Chandra's legacy.

Next-generation pushbroom filter radiometers for remote sensing

NASA Astrophysics Data System (ADS)

Tarde, Richard W.; Dittman, Michael G.; Kvaran, Geir E.

2012-09-01

Individual focal plane size, yield, and quality continue to improve, as does the technology required to combine these into large tiled formats. As a result, next-generation pushbroom imagers are replacing traditional scanning technologies in remote sensing applications. Pushbroom architecture has inherently better radiometric sensitivity and significantly reduced payload mass, power, and volume than previous generation scanning technologies. However, the architecture creates challenges achieving the required radiometric accuracy performance. Achieving good radiometric accuracy, including image spectral and spatial uniformity, requires creative optical design, high quality focal planes and filters, careful consideration of on-board calibration sources, and state-of-the-art ground test facilities. Ball Aerospace built the Landsat Data Continuity Mission (LDCM) next-generation Operational Landsat Imager (OLI) payload. Scheduled to launch in 2013, OLI provides imagery consistent with the historical Landsat spectral, spatial, radiometric, and geometric data record and completes the generational technology upgrade from the Enhanced Thematic Mapper (ETM+) whiskbroom technology to modern pushbroom technology afforded by advanced focal planes. We explain how Ball's capabilities allowed producing the innovative next-generational OLI pushbroom filter radiometer that meets challenging radiometric accuracy or calibration requirements. OLI will improve the multi-decadal land surface observation dataset dating back to the 1972 launch of ERTS-1 or Landsat 1.

Next-generation Digital Earth

PubMed Central

Goodchild, Michael F.; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J.; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

2012-01-01

A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of “big data” has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public’s access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation. PMID:22723346

Next-generation Digital Earth.

PubMed

Goodchild, Michael F; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

2012-07-10

A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of "big data" has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public's access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation.

PARALLAX AND ORBITAL EFFECTS IN ASTROMETRIC MICROLENSING WITH BINARY SOURCES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nucita, A. A.; Paolis, F. De; Ingrosso, G.

2016-06-01

In gravitational microlensing, binary systems may act as lenses or sources. Identifying lens binarity is generally easy, in particular in events characterized by caustic crossing since the resulting light curve exhibits strong deviations from a smooth single-lensing light curve. In contrast, light curves with minor deviations from a Paczyński behavior do not allow one to identify the source binarity. A consequence of gravitational microlensing is the shift of the position of the multiple image centroid with respect to the source star location — the so-called astrometric microlensing signal. When the astrometric signal is considered, the presence of a binary sourcemore » manifests with a path that largely differs from that expected for single source events. Here, we investigate the astrometric signatures of binary sources taking into account their orbital motion and the parallax effect due to the Earth’s motion, which turn out not to be negligible in most cases. We also show that considering the above-mentioned effects is important in the analysis of astrometric data in order to correctly estimate the lens-event parameters.« less

a Theoretical Calculation of Microlensing Signatures Caused by Free-Floating Planets Towards the Galactic Bulge

NASA Astrophysics Data System (ADS)

Hamolli, L.; Hafizi, M.; Nucita, A. A.

2013-08-01

Free-floating planets (FFPs) are recently drawing a special interest of the scientific community. Gravitational microlensing is up to now the exclusive method for the investigation of FFPs, including their spatial distribution function and mass function. In this paper, we examine the possibility that the future Euclid space-based observatory may allow to discover a substantial number of microlensing events caused by FFPs. Based on latest results about the free-floating planet (FFP) mass function in the mass range [10-5, 10-2]M⊙, we calculate the optical depth towards the Galactic bulge as well as the expected microlensing rate and find that Euclid may be able to detect hundreds to thousands of these events per month. Making use of a synthetic population, we also investigate the possibility of detecting parallax effect in simulated microlensing events due to FFPs and find a significant efficiency for the parallax detection that turns out to be around 30%.

The Next Generation Fornax Survey (NGFS). II. The Central Dwarf Galaxy Population

NASA Astrophysics Data System (ADS)

Eigenthaler, Paul; Puzia, Thomas H.; Taylor, Matthew A.; Ordenes-Briceño, Yasna; Muñoz, Roberto P.; Ribbeck, Karen X.; Alamo-Martínez, Karla A.; Zhang, Hongxin; Ángel, Simón; Capaccioli, Massimo; Côté, Patrick; Ferrarese, Laura; Galaz, Gaspar; Grebel, Eva K.; Hempel, Maren; Hilker, Michael; Lançon, Ariane; Mieske, Steffen; Miller, Bryan; Paolillo, Maurizio; Powalka, Mathieu; Richtler, Tom; Roediger, Joel; Rong, Yu; Sánchez-Janssen, Ruben; Spengler, Chelsea

2018-03-01

We present a photometric study of the dwarf galaxy population in the core region (≲r vir/4) of the Fornax galaxy cluster based on deep u‧g‧i‧ photometry from the Next Generation Fornax Cluster Survey. All imaging data were obtained with the Dark Energy Camera mounted on the 4 m Blanco telescope at the Cerro Tololo Interamerican Observatory. We identify 258 dwarf galaxy candidates with luminosities ‑17 ≲ M g‧ ≲ ‑8 mag, corresponding to typical stellar masses of 9.5≳ {log}{{ \\mathcal M }}\\star /{M}ȯ ≳ 5.5, reaching ∼3 mag deeper in point-source luminosity and ∼4 mag deeper in surface brightness sensitivity compared to the classic Fornax Cluster Catalog. Morphological analysis shows that the dwarf galaxy surface-brightness profiles are well represented by single-component Sérsic models with average Sérsic indices of < n{> }u\\prime ,g\\prime ,i\\prime =(0.78{--}0.83)+/- 0.02 and average effective radii of < {r}e{> }u\\prime ,g\\prime ,i\\prime =(0.67{--}0.70)+/- 0.02 {kpc}. Color–magnitude relations indicate a flattening of the galaxy red sequence at faint galaxy luminosities, similar to the one recently discovered in the Virgo cluster. A comparison with population synthesis models and the galaxy mass–metallicity relation reveals that the average faint dwarf galaxy is likely older than ∼5 Gyr. We study galaxy scaling relations between stellar mass, effective radius, and stellar mass surface density over a stellar mass range covering six orders of magnitude. We find that over the sampled stellar mass range several distinct mechanisms of galaxy mass assembly can be identified: (1) dwarf galaxies assemble mass inside the half-mass radius up to {log}{{ \\mathcal M }}\\star ≈ 8.0, (2) isometric mass assembly occurs in the range 8.0 ≲ {log}{{ \\mathcal M }}\\star /{M}ȯ ≲ 10.5, and (3) massive galaxies assemble stellar mass predominantly in their halos at {log}{{ \\mathcal M }}\\star ≈ 10.5 and above.

Digital holographic characterization of liquid microlenses array fabricated in electrode-less configuration

NASA Astrophysics Data System (ADS)

Miccio, L.; Vespini, V.; Grilli, S.; Paturzo, M.; Finizio, A.; De Nicola, S.; Ferraro, P.

2009-06-01

We show how thin liquid film on polar dielectric substrate can form an array of liquid micro-lenses. The effect is driven by the pyroelectric effect leading to a new concept in electro-wetting (EW). EW is a viable method for actuation of liquids in microfluidic systems and requires the design and fabrication of complex electrodes for suitable actuation of liquids. When compared to conventional electrowetting devices, the pyroelectric effect allowed to have an electrode-less and circuitless configuration. In our case the surface electric charge induced by the thermal stimulus is able to pattern selectively the surface wettability according to geometry of the ferroelectric domains micro-engineered into the lithium niobate crystal. We show that different geometries of liquid microlenses can be obtained showing also a tuneability of the focal lenses down to 1.6 mm. Thousand of liquid microlenses, each with 100 μm diameter, can be formed and actuated. Also different geometries such as hemi-cylindrical and toroidal liquid structures can be easily obtained. By means of a digital holography method, an accurate characterization of the micro-lenses curvature is performed and presented. The preliminary results concerning the imaging capability of the micro-lens array are also reported. Microlens array can find application in medical stereo-endoscopy, imaging, telecommunication and optical data storage too.

Educational Approaches When Implementing the Next Generation Science Standards

NASA Astrophysics Data System (ADS)

Dwyer, Brian

This paper overviews the history of science education from the launch of Sputnik through reform movements and associated legislation to the most recent Next Generation Science Standards (NGSS). The paper also considers stakeholder groups that would need to be involved if NGSS is to be implemented properly, including teachers, parents and unions. Each group holds a responsibility within a school system that needs to be addressed from a practical standpoint to increase the likelihood of the effective adoption of the Next Generation Science Standards. This paper provides background and program information about the Next Generation Science Standards (NGSS). It also considers the educational, philosophical, and instructional approach known as inquiry which is strongly advocated by NGSS and explores where and how other well-studied instructional approaches might have a place within an inquiry-based classroom.

Next-generation fiber lasers enabled by high-performance components

NASA Astrophysics Data System (ADS)

Kliner, D. A. V.; Victor, B.; Rivera, C.; Fanning, G.; Balsley, D.; Farrow, R. L.; Kennedy, K.; Hampton, S.; Hawke, R.; Soukup, E.; Reynolds, M.; Hodges, A.; Emery, J.; Brown, A.; Almonte, K.; Nelson, M.; Foley, B.; Dawson, D.; Hemenway, D. M.; Urbanek, W.; DeVito, M.; Bao, L.; Koponen, J.; Gross, K.

2018-02-01

Next-generation industrial fiber lasers enable challenging applications that cannot be addressed with legacy fiber lasers. Key features of next-generation fiber lasers include robust back-reflection protection, high power stability, wide power tunability, high-speed modulation and waveform generation, and facile field serviceability. These capabilities are enabled by high-performance components, particularly pump diodes and optical fibers, and by advanced fiber laser designs. We summarize the performance and reliability of nLIGHT diodes, fibers, and next-generation industrial fiber lasers at power levels of 500 W - 8 kW. We show back-reflection studies with up to 1 kW of back-reflected power, power-stability measurements in cw and modulated operation exhibiting sub-1% stability over a 5 - 100% power range, and high-speed modulation (100 kHz) and waveform generation with a bandwidth 20x higher than standard fiber lasers. We show results from representative applications, including cutting and welding of highly reflective metals (Cu and Al) for production of Li-ion battery modules and processing of carbon fiber reinforced polymers.

The MACHO Project: Microlensing Results from 5.7 Years of LMC Observations

NASA Astrophysics Data System (ADS)

Becker, A. C.; Alcock, C.; Allsman, R. A.; Alves, D.; Axelrod, T. S.; Bennett, D. P.; Cook, K. H.; Drake, A. J.; Freeman, K. C.; Geha, M.; Griest, K.; Lehner, M. J.; Marshall, S. L.; Minniti, D.; Nelson, C. A.; Peterson, B. A.; Popowski, P.; Pratt, M. R.; Quinn, P. J.; Rodgers, A. W.; Stubbs, C. W.; Sutherland, W.; Tomaney, A. B.; Vandehei, T.; Welch, D. L.; MACHO Collaboration

1999-12-01

We report on our search for microlensing towards the Large Magellanic Cloud (LMC). Analysis of 5.7 years of photometry on 11.9 million stars in the LMC reveals 17 candidate microlensing events. A careful treatment of our detection efficiency shows that this is significantly more than the 2 to 4 events expected from lensing by known stellar populations. The timescales (t) of the events range from 34 to 230 days. The spatial distribution of events is probably inconsistent with LMC/LMC disk self-lensing, but consistent with an extended lens distribution such as a Milky Way or LMC halo. The optical depth results appear consistent with, but are lower than, our previous 2.1 year results. Besides a factor of 3.4 increase in exposure, this new work also includes an improved efficiency determination, improved likelihood analysis, and more thorough testing of robustness and systematic errors, especially in regards to the treatment of potential backgrounds to microlensing, such as supernovae in galaxies behind the LMC.

The Impact of Microlensing on the Standardisation of Strongly Lensed Type Ia Supernovae

NASA Astrophysics Data System (ADS)

Foxley-Marrable, Max; Collett, Thomas E.; Vernardos, Georgios; Goldstein, Daniel A.; Bacon, David

2018-05-01

We investigate the effect of microlensing on the standardisation of strongly lensed Type Ia supernovae (GLSNe Ia). We present predictions for the amount of scatter induced by microlensing across a range of plausible strong lens macromodels. We find that lensed images in regions of low convergence, shear and stellar density are standardisable, where the microlensing scatter is ≲ 0.15 magnitudes, comparable to the intrinsic dispersion of for a typical SN Ia. These standardisable configurations correspond to asymmetric lenses with an image located far outside the Einstein radius of the lens. Symmetric and small Einstein radius lenses (≲ 0.5 arcsec) are not standardisable. We apply our model to the recently discovered GLSN Ia iPTF16geu and find that the large discrepancy between the observed flux and the macromodel predictions from More et al. (2017) cannot be explained by microlensing alone. Using the mock GLSNe Ia catalogue of Goldstein et al. (2017), we predict that ˜ 22% of GLSNe Ia discovered by LSST will be standardisable, with a median Einstein radius of 0.9 arcseconds and a median time-delay of 41 days. By breaking the mass-sheet degeneracy the full LSST GLSNe Ia sample will be able to detect systematics in H0 at the 0.5% level.

Self-aligned process for forming microlenses at the tips of vertical silicon nanowires by atomic layer deposition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dan, Yaping, E-mail: yaping.dan@sjtu.edu.cn; Chen, Kaixiang; Crozier, Kenneth B.

The microlens is a key enabling technology in optoelectronics, permitting light to be efficiently coupled to and from devices such as image sensors and light-emitting diodes. Their ubiquitous nature motivates the development of new fabrication techniques, since existing methods face challenges as microlenses are scaled to smaller dimensions. Here, the authors demonstrate the formation of microlenses at the tips of vertically oriented silicon nanowires via a rapid atomic layer deposition process. The nature of the process is such that the microlenses are centered on the nanowires, and there is a self-limiting effect on the final sizes of the microlenses arisingmore » from the nanowire spacing. Finite difference time domain electromagnetic simulations are performed of microlens focusing properties, including showing their ability to enhance visible-wavelength absorption in silicon nanowires.« less

C2 of Next-Generation Satellites

DTIC Science & Technology

2013-06-01

held 19-21 June, 2013 in Alexandria, VA. 14. ABSTRACT Space systems have come to be used so extensively that it is almost impossible to imagine...Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 1 Abstract for: C2 of Next-Generation Satellites Space systems have come to be used so...satellites and payloads noted above have generated intense demand for EM spectrum bandwidth, which is expected to increase exponentially in the coming

Next Generation Multimedia Distributed Data Base Systems

NASA Technical Reports Server (NTRS)

Pendleton, Stuart E.

1997-01-01

The paradigm of client/server computing is changing. The model of a server running a monolithic application and supporting clients at the desktop is giving way to a different model that blurs the line between client and server. We are on the verge of plunging into the next generation of computing technology--distributed object-oriented computing. This is not only a change in requirements but a change in opportunities, and requires a new way of thinking for Information System (IS) developers. The information system demands caused by global competition are requiring even more access to decision making tools. Simply, object-oriented technology has been developed to supersede the current design process of information systems which is not capable of handling next generation multimedia.

Next generation of preventive interventions.

PubMed

Rotheram-Borus, Mary Jane; Duan, Naihua

2003-05-01

With increasing numbers of efficacious prevention programs, the field needs strategies to disseminate the interventions broadly. The authors examined the life course of prevention programs, identified barriers to dissemination, and outlined an alternative dissemination model. Private enterprise models of product development can be viable strategies for increasing the dissemination of the intervention to the general public. Market principles suggest that the next generation of interventions would be facilitated if interventions are initiated by teams committed to a specific problem and investigators receive training in management; if the acceptability of the program's design features to consumers, providers, and funding agencies is established prior to the development and evaluation of the program; if data from national marketing surveys are used to tailor intervention designs and delivery formats for different subgroups; if essential ingredients of the intervention are identified to facilitate adaptation of the program; if the program is implemented with a goal to maintain change over extended periods of time; if the implementation plan includes program evolution over time, rather than replication with fidelity; and if interventions are branded and certified by a credible agency. Private enterprise models may be useful; however, investigators are likely to be resistant given a priori biases, potential ethical conflicts of interest, and the challenges presented by new technologies (e.g., the Internet and Human Genome Project).

The Next Generation of Personal Computers.

ERIC Educational Resources Information Center

Crecine, John P.

1986-01-01

Discusses factors converging to create high-capacity, low-cost nature of next generation of microcomputers: a coherent vision of what graphics workstation and future computing environment should be like; hardware developments leading to greater storage capacity at lower costs; and development of software and expertise to exploit computing power…

A Next-Generation Sequencing Primer—How Does It Work and What Can It Do?

PubMed Central

Alekseyev, Yuriy O.; Fazeli, Roghayeh; Yang, Shi; Basran, Raveen; Miller, Nancy S.

2018-01-01

Next-generation sequencing refers to a high-throughput technology that determines the nucleic acid sequences and identifies variants in a sample. The technology has been introduced into clinical laboratory testing and produces test results for precision medicine. Since next-generation sequencing is relatively new, graduate students, medical students, pathology residents, and other physicians may benefit from a primer to provide a foundation about basic next-generation sequencing methods and applications, as well as specific examples where it has had diagnostic and prognostic utility. Next-generation sequencing technology grew out of advances in multiple fields to produce a sophisticated laboratory test with tremendous potential. Next-generation sequencing may be used in the clinical setting to look for specific genetic alterations in patients with cancer, diagnose inherited conditions such as cystic fibrosis, and detect and profile microbial organisms. This primer will review DNA sequencing technology, the commercialization of next-generation sequencing, and clinical uses of next-generation sequencing. Specific applications where next-generation sequencing has demonstrated utility in oncology are provided. PMID:29761157

VizieR Online Data Catalog: OGLE-II DIA microlensing events (Wozniak+, 2001)

NASA Astrophysics Data System (ADS)

Wozniak, P. R.; Udalski, A.; Szymanski, M.; Kubiak, M.; Pietrzynski, G.; Soszynski, I.; Zebrun, K.

2002-11-01

We present a sample of microlensing events discovered in the Difference Image Analysis (DIA) of the OGLE-II images collected during three observing seasons, 1997-1999. 4424 light curves pass our criteria on the presence of a brightening episode on top of a constant baseline. Among those, 512 candidate microlensing events were selected visually. We designed an automated procedure, which unambiguously selects up to 237 best events. Including eight candidate events recovered by other means, a total of 520 light curves are presented in this work. (4 data files).

Next Generation Remote Agent Planner

NASA Technical Reports Server (NTRS)

Jonsson, Ari K.; Muscettola, Nicola; Morris, Paul H.; Rajan, Kanna

1999-01-01

In May 1999, as part of a unique technology validation experiment onboard the Deep Space One spacecraft, the Remote Agent became the first complete autonomous spacecraft control architecture to run as flight software onboard an active spacecraft. As one of the three components of the architecture, the Remote Agent Planner had the task of laying out the course of action to be taken, which included activities such as turning, thrusting, data gathering, and communicating. Building on the successful approach developed for the Remote Agent Planner, the Next Generation Remote Agent Planner is a completely redesigned and reimplemented version of the planner. The new system provides all the key capabilities of the original planner, while adding functionality, improving performance and providing a modular and extendible implementation. The goal of this ongoing project is to develop a system that provides both a basis for future applications and a framework for further research in the area of autonomous planning for spacecraft. In this article, we present an introductory overview of the Next Generation Remote Agent Planner. We present a new and simplified definition of the planning problem, describe the basics of the planning process, lay out the new system design and examine the functionality of the core reasoning module.

Next-generation genome-scale models for metabolic engineering.

PubMed

King, Zachary A; Lloyd, Colton J; Feist, Adam M; Palsson, Bernhard O

2015-12-01

Constraint-based reconstruction and analysis (COBRA) methods have become widely used tools for metabolic engineering in both academic and industrial laboratories. By employing a genome-scale in silico representation of the metabolic network of a host organism, COBRA methods can be used to predict optimal genetic modifications that improve the rate and yield of chemical production. A new generation of COBRA models and methods is now being developed--encompassing many biological processes and simulation strategies-and next-generation models enable new types of predictions. Here, three key examples of applying COBRA methods to strain optimization are presented and discussed. Then, an outlook is provided on the next generation of COBRA models and the new types of predictions they will enable for systems metabolic engineering. Copyright © 2014 Elsevier Ltd. All rights reserved.

Implementing the Next Generation Science Standards

ERIC Educational Resources Information Center

Penuel, William R.; Harris, Christopher J.; DeBarger, Angela Haydel

2015-01-01

The Next Generation Science Standards embody a new vision for science education grounded in the idea that science is both a body of knowledge and a set of linked practices for developing knowledge. The authors describe strategies that they suggest school and district leaders consider when designing strategies to support NGSS implementation.

Next Generation Ceramic Substrate Fabricated at Room Temperature.

PubMed

Kim, Yuna; Ahn, Cheol-Woo; Choi, Jong-Jin; Ryu, Jungho; Kim, Jong-Woo; Yoon, Woon-Ha; Park, Dong-Soo; Yoon, Seog-Young; Ma, Byungjin; Hahn, Byung-Dong

2017-07-26

A ceramic substrate must not only have an excellent thermal performance but also be thin, since the electronic devices have to become thin and small in the electronics industry of the next generation. In this manuscript, a thin ceramic substrate (thickness: 30-70 µm) is reported for the next generation ceramic substrate. It is fabricated by a new process [granule spray in vacuum (GSV)] which is a room temperature process. For the thin ceramic substrates, AlN GSV films are deposited on Al substrates and their electric/thermal properties are compared to those of the commercial ceramic substrates. The thermal resistance is significantly reduced by using AlN GSV films instead of AlN bulk-ceramics in thermal management systems. It is due to the removal of a thermal interface material which has low thermal conductivity. In particular, the dielectric strengths of AlN GSV films are much higher than those of AlN bulk-ceramics which are commercialized, approximately 5 times. Therefore, it can be expected that this GSV film is a next generation substrate in thermal management systems for the high power application.

Next-Generation Sequencing Platforms

NASA Astrophysics Data System (ADS)

Mardis, Elaine R.

2013-06-01

Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's founding discovery of dideoxynucleotide sequencing to perform once-unfathomable tasks. Combined with innovative physical mapping approaches that helped to establish long-range relationships between cloned stretches of genomic DNA, fluorescent DNA sequencers produced reference genome sequences for model organisms and for the reference human genome. New types of sequencing instruments that permit amazing acceleration of data-collection rates for DNA sequencing have been developed. The ability to generate genome-scale data sets is now transforming the nature of biological inquiry. Here, I provide an historical perspective of the field, focusing on the fundamental developments that predated the advent of next-generation sequencing instruments and providing information about how these instruments work, their application to biological research, and the newest types of sequencers that can extract data from single DNA molecules.

NASA/NREN: Next Generation Internet (NGI) Activities

NASA Technical Reports Server (NTRS)

desJardins, Richard; Freeman, Ken

1998-01-01

Various issues associated with next generation internet (NGI) and the NREN (NASA Research and Education Network) activities are presented in viewgraph form. Specific topics include: 1) NREN architecture; 2) NREN applications; and 3) NREN applied research.

Unbundling in Current Broadband and Next-Generation Ultra-Broadband Access Networks

NASA Astrophysics Data System (ADS)

Gaudino, Roberto; Giuliano, Romeo; Mazzenga, Franco; Valcarenghi, Luca; Vatalaro, Francesco

2014-05-01

This article overviews the methods that are currently under investigation for implementing multi-operator open-access/shared-access techniques in next-generation access ultra-broadband architectures, starting from the traditional "unbundling-of-the-local-loop" techniques implemented in legacy twisted-pair digital subscriber line access networks. A straightforward replication of these copper-based unbundling-of-the-local-loop techniques is usually not feasible on next-generation access networks, including fiber-to-the-home point-to-multipoint passive optical networks. To investigate this issue, the article first gives a concise description of traditional copper-based unbundling-of-the-local-loop solutions, then focalizes on both next-generation access hybrid fiber-copper digital subscriber line fiber-to-the-cabinet scenarios and on fiber to the home by accounting for the mix of regulatory and technological reasons driving the next-generation access migration path, focusing mostly on the European situation.

Mobile e-Learning for Next Generation Communication Environment

ERIC Educational Resources Information Center

Wu, Tin-Yu; Chao, Han-Chieh

2008-01-01

This article develops an environment for mobile e-learning that includes an interactive course, virtual online labs, an interactive online test, and lab-exercise training platform on the fourth generation mobile communication system. The Next Generation Learning Environment (NeGL) promotes the term "knowledge economy." Inter-networking…

Gravitational microlensing by low-mass objects in the globular cluster M22.

PubMed

Sahu, K C; Casertano, S; Livio, M; Gilliland, R L; Panagia, N; Albrow, M D; Potter, M

2001-06-28

Gravitational microlensing offers a means of determining directly the masses of objects ranging from planets to stars, provided that the distances and motions of the lenses and sources can be determined. A globular cluster observed against the dense stellar field of the Galactic bulge presents ideal conditions for such observations because the probability of lensing is high and the distances and kinematics of the lenses and sources are well constrained. The abundance of low-mass objects in a globular cluster is of particular interest, because it may be representative of the very early stages of star formation in the Universe, and therefore indicative of the amount of dark baryonic matter in such clusters. Here we report a microlensing event associated with the globular cluster M22. We determine the mass of the lens to be 0.13(+0.03)(-0.02) solar masses. We have also detected six events that are unresolved in time. If these are also microlensing events, they imply that a non-negligible fraction of the cluster mass resides in the form of free-floating planetary-mass objects.

REVIEWS OF TOPICAL PROBLEMS: Small-scale structure of dark matter and microlensing

NASA Astrophysics Data System (ADS)

Gurevich, Aleksandr V.; Zybin, Kirill P.; Sirota, V. A.

1997-09-01

It has been revealed using microlensing that a considerable part, possibly more than half, of the dark matter in the halo of our Galaxy consists of objects with a mass spectrum ranging from 0.05 to 0.8 of the solar mass. What is the nature of these objects? There exist two hypotheses. According to one, these are Jupiter type planets or small stars (brown and white dwarfs) consisting of normal baryonic matter. According to the other, these are non-compact objects, i.e., small-scale formations in non-baryonic dark matter. Here, a theory is proposed describing the possibility of the existence of non-compact objects in the halo of our Galaxy, their structure and formation from non-baryonic matter. The theory of microlensing on compact and non-compact objects is considered in detail. The results of microlensing observations are described and compared with theory. Possible astrophysical manifestations of the presence of small-scale structure are pointed out. The field is being extensively studied and is of fundamental interest for cosmology and astrophysics.

Confocal microscopy using variable-focal-length microlenses and an optical fiber bundle.

PubMed

Yang, Lisong; Mac Raighne, Aaron; McCabe, Eithne M; Dunbar, L Andrea; Scharf, Toralf

2005-10-01

The use of variable-focal-length (VFL) microlenses can provide a way to axially scan the foci across a sample by electronic control. We demonstrate an approach to coupling VFL microlenses individually to a fiber bundle as a way to create a high-throughput aperture array with a controllable aperture pattern. It would potentially be applied in real-time confocal imaging in vivo for biological specimens. The VFL microlenses that we used consist of a liquid-crystal film sandwiched between a pair of conductive substrates for which one has a hole-patterned electrode. One obtains the variation of the focal length by changing the applied voltage. The fiber bundle has been characterized by coupling with both coherent and incoherent light sources. We further demonstrate the use of a VFL microlens array in combination with the fiber bundle to build up a confocal system. The axial response of the confocal system has been measured without mechanical movement of the sample or the objective, and the FWHM is estimated to be approximately 16 microm, with asymmetric sidelobes.

Contamination in the MACHO data set and the puzzle of Large Magellanic Cloud microlensing

NASA Astrophysics Data System (ADS)

Griest, Kim; Thomas, Christian L.

2005-05-01

In a recent series of three papers, Belokurov, Evans & Le Du and Evans & Belokurov reanalysed the MACHO collaboration data and gave alternative sets of microlensing events and an alternative optical depth to microlensing towards the Large Magellanic Cloud (LMC). Although these authors examined less than 0.2 per cent of the data, they reported that by using a neural net program they had reliably selected a better (and smaller) set of microlensing candidates. Estimating the optical depth from this smaller set, they claimed that the MACHO collaboration overestimated the optical depth by a significant factor and that the MACHO microlensing experiment is consistent with lensing by known stars in the Milky Way and LMC. As we show below, the analysis by these authors contains several errors, and as a result their conclusions are incorrect. Their efficiency analysis is in error, and since they did not search through the entire MACHO data set, they do not know how many microlensing events their neural net would find in the data nor what optical depth their method would give. Examination of their selected events suggests that their method misses low signal-to-noise ratio events and thus would have lower efficiency than the MACHO selection criteria. In addition, their method is likely to give many more false positives (non-lensing events identified as lensing). Both effects would increase their estimated optical depth. Finally, we note that the EROS discovery that LMC event 23 is a variable star reduces the MACHO collaboration estimates of optical depth and the Macho halo fraction by around 8 per cent, and does open the question of additional contamination.

Effect of Binary Source Companions on the Microlensing Optical Depth Determination toward the Galactic Bulge Field

NASA Astrophysics Data System (ADS)

Han, Cheongho

2005-11-01

Currently, gravitational microlensing survey experiments toward the Galactic bulge field use two different methods of minimizing the blending effect for the accurate determination of the optical depth τ. One is measuring τ based on clump giant (CG) source stars, and the other is using ``difference image analysis'' (DIA) photometry to measure the unblended source flux variation. Despite the expectation that the two estimates should be the same assuming that blending is properly considered, the estimates based on CG stars systematically fall below the DIA results based on all events with source stars down to the detection limit. Prompted by the gap, we investigate the previously unconsidered effect of companion-associated events on τ determination. Although the image of a companion is blended with that of its primary star and thus not resolved, the event associated with the companion can be detected if the companion flux is highly magnified. Therefore, companions work effectively as source stars to microlensing, and thus the neglect of them in the source star count could result in a wrong τ estimation. By carrying out simulations based on the assumption that companions follow the same luminosity function as primary stars, we estimate that the contribution of the companion-associated events to the total event rate is ~5fbi% for current surveys and can reach up to ~6fbi% for future surveys monitoring fainter stars, where fbi is the binary frequency. Therefore, we conclude that the companion-associated events comprise a nonnegligible fraction of all events. However, their contribution to the optical depth is not large enough to explain the systematic difference between the optical depth estimates based on the two different methods.

The impact of large-scale, long-term optical surveys on pulsating star research

NASA Astrophysics Data System (ADS)

Soszyński, Igor

2017-09-01

The era of large-scale photometric variability surveys began a quarter of a century ago, when three microlensing projects - EROS, MACHO, and OGLE - started their operation. These surveys initiated a revolution in the field of variable stars and in the next years they inspired many new observational projects. Large-scale optical surveys multiplied the number of variable stars known in the Universe. The huge, homogeneous and complete catalogs of pulsating stars, such as Cepheids, RR Lyrae stars, or long-period variables, offer an unprecedented opportunity to calibrate and test the accuracy of various distance indicators, to trace the three-dimensional structure of the Milky Way and other galaxies, to discover exotic types of intrinsically variable stars, or to study previously unknown features and behaviors of pulsators. We present historical and recent findings on various types of pulsating stars obtained from the optical large-scale surveys, with particular emphasis on the OGLE project which currently offers the largest photometric database among surveys for stellar variability.

Next-generation mammalian genetics toward organism-level systems biology.

PubMed

Susaki, Etsuo A; Ukai, Hideki; Ueda, Hiroki R

2017-01-01

Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals. In particular, system-level identification and analysis of molecular and cellular networks can be accelerated by next-generation mammalian genetics. Mammalian genetics without crossing, where all production and phenotyping studies of genome-edited animals are completed within a single generation drastically reduce the time, space, and effort of conducting the systems research. Next-generation mammalian genetics is based on recent technological advancements in genome editing and developmental engineering. The process begins with introduction of double-strand breaks into genomic DNA by using site-specific endonucleases, which results in highly efficient genome editing in mammalian zygotes or embryonic stem cells. By using nuclease-mediated genome editing in zygotes, or ~100% embryonic stem cell-derived mouse technology, whole-body knock-out and knock-in mice can be produced within a single generation. These emerging technologies allow us to produce multiple knock-out or knock-in strains in high-throughput manner. In this review, we discuss the basic concepts and related technologies as well as current challenges and future opportunities for next-generation mammalian genetics in organism-level systems biology.

Revealing stellar brightness profiles by means of microlensing fold caustics

NASA Astrophysics Data System (ADS)

Dominik, M.

2004-09-01

With a handful of measurements of limb-darkening coefficients, galactic microlensing has already proven to be a powerful technique for studying atmospheres of distant stars. Survey campaigns such as OGLE-III are capable of providing ~10 suitable target stars per year that undergo microlensing events involving passages over the caustic created by a binary lens, which last from a few hours to a few days and allow us to resolve the stellar atmosphere by frequent broad-band photometry. For a caustic exit lasting 12 h and a photometric precision of 1.5 per cent, a moderate sampling interval of 30 min (corresponding to ~25-30 data points) is sufficient for providing a reliable measurement of the linear limb-darkening coefficient Γ with an uncertainty of ~8 per cent, which reduces to ~3 per cent for a reduced sampling interval of 6 min for the surroundings of the end of the caustic exit. While some additional points over the remaining parts of the light curve are highly valuable, a denser sampling in these regions provides little improvement. Unless an accuracy of less than 5 per cent is desired, limb-darkening coefficients for several filters can be obtained or observing time can be spent on other targets during the same night. The adoption of an inappropriate stellar brightness profile as well as the effect of acceleration between source and caustic yield distinguishable characteristic systematics in the model residuals. Acceleration effects are unlikely to affect the light curve significantly for most events, although a free acceleration parameter blurs the limb-darkening measurement if the passage duration cannot be accurately determined.

Designing the next generation of robotic controllers

NASA Technical Reports Server (NTRS)

Goldstein, David G.

1994-01-01

The use of scenario-based, object-oriented software engineering methodologies in the next generation of robotic controllers is discussed. The controllers are intended to supplant the decades old technology currently embraced by the manufacturing industry of the United States.

Data Analysis and Next Generation Assessments

ERIC Educational Resources Information Center

Pon, Kathy

2013-01-01

For the last decade, much of the work of California school administrators has been shaped by the accountability of the No Child Left Behind Act. Now as they stand at the precipice of Common Core Standards and next generation assessments, it is important to reflect on the proficiency educators have attained in using data to improve instruction and…

Strong Chromatic Microlensing in HE0047-1756 and SDSS1155+6346

NASA Astrophysics Data System (ADS)

Rojas, K.; Motta, V.; Mediavilla, E.; Falco, E.; Jiménez-Vicente, J.; Muñoz, J. A.

2014-12-01

We use spectra of the double-lensed quasars HE0047-1756 and SDSS1155+6346 to study their unresolved structure through the impact of microlensing. There is no significant evidence of microlensing in the emission line profiles except for the Lyα line of SDSS1155+6346, which shows strong differences in the shapes for images A and B. However, the continuum of the B image spectrum in SDSS1155+6346 is strongly contaminated by the lens galaxy, and these differences should be considered with caution. Using the flux ratios of the emission lines for image pairs as a baseline to remove macro-magnification and extinction, we have detected strong chromatic microlensing in the continuum measured by CASTLES (www.cfa.harvard.edu/castles/) in both lens systems, with amplitudes 0.09(λ16000) <~ |Δm| <~ 0.8(λ5439) for HE0047-1756, and 0.2(λ16000) <~ |Δm| <~ 0.8(λ5439) for SDSS1155+6346. Using magnification maps to simulate microlensing and modeling the accretion disk as a Gaussian source (I vprop exp(-R 2/2r ^2_s)) of size r s vprop λ p , we find r s = 2.5-1.4+3.0 \\sqrt{M/0.3M⊙ } lt-day and p = 2.3 ± 0.8 at the rest frame for λ = 2045 for HE0047-1756 (log prior) and r s = 5.5-3.3+8.2 \\sqrt{M/0.3M⊙ } lt-day and p = 1.5 ± 0.6 at the rest frame of λ = 1398 for SDSS1155+6346 (log prior). Contrary to other studied lens systems, the chromaticity detected in HE0047-1756 and SDSS1155+6346 is large enough to fulfill the thin disk prediction. The inferred sizes, however, are very large compared to the predictions of this model, especially in the case of SDSS1155+6346.

Next Generation Drivetrain Development and Test Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Jonathan; Erdman, Bill; Blodgett, Doug

2015-11-03

This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

Assessing Written Communication in Higher Education: Review and Recommendations for Next-Generation Assessment. Research Report. ETS RR-14-37

ERIC Educational Resources Information Center

Sparks, Jesse R.; Song, Yi; Brantley, Wyman; Liu, Ou Lydia

2014-01-01

Written communication is considered one of the most critical competencies for academic and career success, as evident in surveys of stakeholders from higher education and the workforce. Emphasis on writing skills suggests the need for next-generation assessments of writing proficiency to inform curricular and instructional improvement. This…

Implementing Elementary School Next Generation Science Standards

ERIC Educational Resources Information Center

Kennedy, Katheryn B.

2017-01-01

Implementation of the Next Generation Science Standards requires developing elementary teacher content and pedagogical content knowledge of science and engineering concepts. Teacher preparation for this undertaking appears inadequate with little known about how in-service Mid-Atlantic urban elementary science teachers approach this task. The…

Limits on the Mass and Abundance of Primordial Black Holes from Quasar Gravitational Microlensing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mediavilla, E.; Jiménez-Vicente, J.; Calderón-Infante, J.

The idea that dark matter can be made of intermediate-mass primordial black holes (PBHs) in the 10 M {sub ⊙} ≲ M ≲ 200 M {sub ⊙} range has recently been reconsidered, particularly in the light of the detection of gravitational waves by the LIGO experiment. The existence of even a small fraction of dark matter in black holes should nevertheless result in noticeable quasar gravitational microlensing. Quasar microlensing is sensitive to any type of compact objects in the lens galaxy, to their abundance, and to their mass. We have analyzed optical and X-ray microlensing data from 24 gravitationally lensedmore » quasars to estimate the abundance of compact objects in a very wide range of masses. We conclude that the fraction of mass in black holes or any type of compact objects is negligible outside of the 0.05 M {sub ⊙} ≲ M ≲ 0.45 M {sub ⊙} mass range and that it amounts to 20% ± 5% of the total matter, in agreement with the expected masses and abundances of the stellar component. Consequently, the existence of a significant population of intermediate-mass PBHs appears to be inconsistent with current microlensing observations. Therefore, primordial massive black holes are a very unlikely source of the gravitational radiation detected by LIGO.« less

Applications of nanotechnology, next generation sequencing and microarrays in biomedical research.

PubMed

Elingaramil, Sauli; Li, Xiaolong; He, Nongyue

2013-07-01

Next-generation sequencing technologies, microarrays and advances in bio nanotechnology have had an enormous impact on research within a short time frame. This impact appears certain to increase further as many biomedical institutions are now acquiring these prevailing new technologies. Beyond conventional sampling of genome content, wide-ranging applications are rapidly evolving for next-generation sequencing, microarrays and nanotechnology. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted re sequencing and discovery of transcription factor binding sites, noncoding RNA expression profiling and molecular diagnostics. This paper thus discusses current applications of nanotechnology, next-generation sequencing technologies and microarrays in biomedical research and highlights the transforming potential these technologies offer.

Towards Intelligent Control for Next Generation Aircraft

NASA Technical Reports Server (NTRS)

Acosta, Diana Michelle; KrishnaKumar, Kalmanje Srinvas; Frost, Susan Alane

2008-01-01

NASA Aeronautics Subsonic Fixed Wing Project is focused on mitigating the environmental and operation impacts expected as aviation operations triple by 2025. The approach is to extend technological capabilities and explore novel civil transport configurations that reduce noise, emissions, fuel consumption and field length. Two Next Generation (NextGen) aircraft have been identified to meet the Subsonic Fixed Wing Project goals - these are the Hybrid Wing-Body (HWB) and Cruise Efficient Short Take-Off and Landing (CESTOL) aircraft. The technologies and concepts developed for these aircraft complicate the vehicle s design and operation. In this paper, flight control challenges for NextGen aircraft are described. The objective of this paper is to examine the potential of state-of-the-art control architectures and algorithms to meet the challenges and needed performance metrics for NextGen flight control. A broad range of conventional and intelligent control approaches are considered, including dynamic inversion control, integrated flight-propulsion control, control allocation, adaptive dynamic inversion control, data-based predictive control and reinforcement learning control.

[Promising Future in General Internal Medicine for the Next Generation of Physicians].

PubMed

Allenbach, Victoria Perpinias; Rozsnyai, Zsofia; Streit, Sven

2018-06-01

Promising Future in General Internal Medicine for the Next Generation of Physicians Abstract. We are facing a lack of specialists in general internal medicine in general practitioners' practices as well as in hospitals, while at the same time the population ages and usually displays several chronic diseases (multimorbidity). Thanks to more university places, an improved job description for general internal medicine and new further education offers (curricula), interest in general internal medicine increased again, as surveys of students indicate. The young generation of family doctors and generalists in hospitals wishes flexible working conditions in order to reconcile work, family and spare time in the best possible way. Working atmosphere and colleagues have a high priority. These wishes must now be incorporated into attractive further training with flexible curricula and mentoring offers so that young talents can successfully be promoted.

Modular approach to achieving the next-generation X-ray light source

NASA Astrophysics Data System (ADS)

Biedron, S. G.; Milton, S. V.; Freund, H. P.

2001-12-01

A modular approach to the next-generation light source is described. The "modules" include photocathode, radio-frequency, electron guns and their associated drive-laser systems, linear accelerators, bunch-compression systems, seed laser systems, planar undulators, two-undulator harmonic generation schemes, high-gain harmonic generation systems, nonlinear higher harmonics, and wavelength shifting. These modules will be helpful in distributing the next-generation light source to many more laboratories than the current single-pass, high-gain free-electron laser designs permit, due to both monetary and/or physical space constraints.

A method for the microlensed flux variance of QSOs

NASA Astrophysics Data System (ADS)

Goodman, Jeremy; Sun, Ai-Lei

2014-06-01

A fast and practical method is described for calculating the microlensed flux variance of an arbitrary source by uncorrelated stars. The required inputs are the mean convergence and shear due to the smoothed potential of the lensing galaxy, the stellar mass function, and the absolute square of the Fourier transform of the surface brightness in the source plane. The mathematical approach follows previous authors but has been generalized, streamlined, and implemented in publicly available code. Examples of its application are given for Dexter and Agol's inhomogeneous-disc models as well as the usual Gaussian sources. Since the quantity calculated is a second moment of the magnification, it is only logarithmically sensitive to the sizes of very compact sources. However, for the inferred sizes of actual quasi-stellar objects (QSOs), it has some discriminatory power and may lend itself to simple statistical tests. At the very least, it should be useful for testing the convergence of microlensing simulations.

Microlensing of Kepler stars as a method of detecting primordial black hole dark matter.

PubMed

Griest, Kim; Lehner, Matthew J; Cieplak, Agnieszka M; Jain, Bhuvnesh

2011-12-02

If the dark matter consists of primordial black holes (PBHs), we show that gravitational lensing of stars being monitored by NASA's Kepler search for extrasolar planets can cause significant numbers of detectable microlensing events. A search through the roughly 150,000 light curves would result in large numbers of detectable events for PBHs in the mass range 5×10(-10) M(⊙) to 10(-4) M(⊙). Nondetection of these events would close almost 2 orders of magnitude of the mass window for PBH dark matter. The microlensing rate is higher than previously noticed due to a combination of the exceptional photometric precision of the Kepler mission and the increase in cross section due to the large angular sizes of the relatively nearby Kepler field stars. We also present a new formalism for calculating optical depth and microlensing rates in the presence of large finite-source effects. © 2011 American Physical Society

ESO Public Surveys at VISTA: Lessons learned from Cycle 1 Surveys and the start of Cycle 2

NASA Astrophysics Data System (ADS)

Arnaboldi, M.; Delmotte, N.; Gadotti, D.; Hilker, M.; Hussain, G.; Mascetti, L.; Micol, A.; Petr-Gotzens, M.; Rejkuba, M.; Retzlaff, J.; Ivison, R.; Leibundgut, B.; Romaniello, M.

2017-06-01

The ESO Public Surveys on VISTA serve the science goals of the survey teams while increasing the legacy value of ESO programmes, thanks to their homogeneity and the breadth of their sky coverage in multiple bands. These projects address a variety of research areas: from the detection of planets via microlensing, to stars, the Milky Way and Local Group galaxies, to extragalactic astronomy, galaxy evolution, the high-redshift Universe and cosmology. In 2015, as the first generation of imaging surveys was nearing completion, a second call for Public Surveys was opened to define a coherent scientific programme for VISTA until the commissioning of the wide-field multi-fibre spectrograph, 4MOST, in 2020. This article presents the status of the Cycle 1 surveys as well as an overview of the seven new programmes in Cycle 2, including their science goals, coverage on the sky and observing strategies. We conclude with a forward look at the Cycle 2 data releases and the timelines for their release.

Fluorescent sensing with Fresnel microlenses for optofluidic systems

NASA Astrophysics Data System (ADS)

Siudzińska, Anna; Miszczuk, Andrzej; Marczak, Jacek; Komorowska, Katarzyna

2017-05-01

The concept of fluorescent sensing in a microchannel equipped with focusing light Fresnel lenses has been demonstrated. The concept employs a line or array of Fresnel lenses generating a line or array of focused light spots within a microfluidic channel, to increase the sensitivity of fluorescent signal detection in the system. We have presented efficient methods of master mold fabrication based on the lithography method and focused ion beam milling. The flexible microchannel was fabricated by an imprint process with new thiolene-epoxy resin with a good ability to replicate even submicron-size features. For final imprinted lenses, the measured background to peak signal level shows more than nine times the increase in brightness at the center of the focal spot for the green part of the spectrum (532 nm). The effectiveness of the microlenses in fluorescent-marked Escherichia coli bacteria was confirmed in a basic fluoroscope experiment, showing the increase of the sensitivity of the detection by the order of magnitude.

Educating the Next Generation of Agricultural Scientists.

ERIC Educational Resources Information Center

National Academy of Sciences - National Research Council, Washington, DC. Board on Agriculture.

The Committee on Evaluation of Trends in Agricultural Research at the Doctoral and Postdoctoral Level was established to analyze issues related to the next generation of agricultural scientists. This report contains the findings, conclusions, and recommendations regarding the status and future needs of agricultural scientists. This report focuses…

The Next Generation Space Telescope

NASA Technical Reports Server (NTRS)

Mather, John C.; Seery, Bernard (Technical Monitor)

2001-01-01

The Next Generation Space Telescope NGST is an 6-7 m class radiatively cooled telescope, planned for launch to the Lagrange point L2 in 2009, to be built by a partnership of NASA, ESA, and CSA. The NGST science program calls for three core instruments: 1) Near IR camera, 0.6 - 5 micrometer; 2) Near IR multiobject spectrometer, 1 - 5 micrometer, and 3) Mid IR camera and spectrometer, 5 - 28 micrometers. I will report on the scientific goals, project status, and the recent reduction in aperture from the target of 8 m.

Next Generation NASA GA Advanced Concept

NASA Technical Reports Server (NTRS)

Hahn, Andrew S.

2006-01-01

Not only is the common dream of frequent personal flight travel going unfulfilled, the current generation of General Aviation (GA) is facing tremendous challenges that threaten to relegate the Single Engine Piston (SEP) aircraft market to a footnote in the history of U.S. aviation. A case is made that this crisis stems from a generally low utility coupled to a high cost that makes the SEP aircraft of relatively low transportation value and beyond the means of many. The roots of this low value are examined in a broad sense, and a Next Generation NASA Advanced GA Concept is presented that attacks those elements addressable by synergistic aircraft design.

Skyshine study for next generation of fusion devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gohar, Y.; Yang, S.

1987-02-01

A shielding analysis for next generation of fusion devices (ETR/INTOR) was performed to study the dose equivalent outside the reactor building during operation including the contribution from neutrons and photons scattered back by collisions with air nuclei (skyshine component). Two different three-dimensional geometrical models for a tokamak fusion reactor based on INTOR design parameters were developed for this study. In the first geometrical model, the reactor geometry and the spatial distribution of the deuterium-tritium neutron source were simplified for a parametric survey. The second geometrical model employed an explicit representation of the toroidal geometry of the reactor chamber and themore » spatial distribution of the neutron source. The MCNP general Monte Carlo code for neutron and photon transport was used to perform all the calculations. The energy distribution of the neutron source was used explicitly in the calculations with ENDF/B-V data. The dose equivalent results were analyzed as a function of the concrete roof thickness of the reactor building and the location outside the reactor building.« less

Next-Generation Pathology.

PubMed

Caie, Peter D; Harrison, David J

2016-01-01

The field of pathology is rapidly transforming from a semiquantitative and empirical science toward a big data discipline. Large data sets from across multiple omics fields may now be extracted from a patient's tissue sample. Tissue is, however, complex, heterogeneous, and prone to artifact. A reductionist view of tissue and disease progression, which does not take this complexity into account, may lead to single biomarkers failing in clinical trials. The integration of standardized multi-omics big data and the retention of valuable information on spatial heterogeneity are imperative to model complex disease mechanisms. Mathematical modeling through systems pathology approaches is the ideal medium to distill the significant information from these large, multi-parametric, and hierarchical data sets. Systems pathology may also predict the dynamical response of disease progression or response to therapy regimens from a static tissue sample. Next-generation pathology will incorporate big data with systems medicine in order to personalize clinical practice for both prognostic and predictive patient care.

Potential of OFDM for next generation optical access

NASA Astrophysics Data System (ADS)

Fritzsche, Daniel; Weis, Erik; Breuer, Dirk

2011-01-01

This paper shows the requirements for next generation optical access (NGOA) networks and analyzes the potential of OFDM (orthogonal frequency division multiplexing) for the use in such network scenarios. First, we show the motivation for NGOA systems based on the future requirements on FTTH access systems and list the advantages of OFDM in such scenarios. In the next part, the basics of OFDM and different methods to generate and detect optical OFDM signals are explained and analyzed. At the transmitter side the options include intensity modulation and the more advanced field modulation of the optical OFDM signal. At the receiver there is the choice between direct detection and coherent detection. As the result of this discussion we show our vision of the future use of OFDM in optical access networks.

Next-Generation Botnet Detection and Response

DTIC Science & Technology

2008-06-24

REPORT Final Report of "Next-Generation Botnet Detection and Response" 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: In this project, we developed...and Wenke Lee. ?In Proceedings of The 13th Annual Network and Distributed System Security Symposium (NDSS 2006), San Diego, CA, February 2006. 2...In Proceedings of The 16th USENIX Security Symposium ( Security 󈧋), Boston, MA, August 2007. 3. A Taxonomy of Botnet Structures. ?David Dagon, Guofei

Emergency management leadership in 2030: Shaping the next generation meta-leader.

PubMed

Cwiak, Carol L; Campbell, Ronald; Cassavechia, Matthew G; Haynes, Chuck; Lloyd, Lanita A; Brockway, Neil; Navarini, George O; Piatt, Byron E; Senger, Mary

The complexities, interdependencies, and ambiguity that face next generation emergency management meta-leaders in an ever-evolving global community heighten the expectation and need for competencies that far exceed those common in practice today and necessitate the ability to move seamlessly through the dimensions of meta-leadership (ie, the person, the situation, and connectivity) while utilizing scientific-based evidence, information, resources, processes, and tools. The objective of this effort was to examine the recently developed next generation emergency management competencies through a meta-leadership lens by juxtaposing the competencies and the meta-leadership model. This resulted in a new framing of the skills and attributes within the meta-leadership model as they are relevant to each competency. Selected trends, drivers, and challenges were used to provide examples within each competency area of the utility of meta-leadership to next generation emergency management practice. This effort also offers training and education implications for next generation emergency management meta-leaders. The examination of the new framing created in this effort is intended to prompt dialog and research within the emergency management practice and academic communities that furthers the practice and study of emergency management.

THE TRAINING OF NEXT GENERATION DATA SCIENTISTS IN BIOMEDICINE.

PubMed

Garmire, Lana X; Gliske, Stephen; Nguyen, Quynh C; Chen, Jonathan H; Nemati, Shamim; VAN Horn, John D; Moore, Jason H; Shreffler, Carol; Dunn, Michelle

2017-01-01

With the booming of new technologies, biomedical science has transformed into digitalized, data intensive science. Massive amount of data need to be analyzed and interpreted, demand a complete pipeline to train next generation data scientists. To meet this need, the transinstitutional Big Data to Knowledge (BD2K) Initiative has been implemented since 2014, complementing other NIH institutional efforts. In this report, we give an overview the BD2K K01 mentored scientist career awards, which have demonstrated early success. We address the specific trainings needed in representative data science areas, in order to make the next generation of data scientists in biomedicine.

A two-stage flow-based intrusion detection model for next-generation networks.

PubMed

Umer, Muhammad Fahad; Sher, Muhammad; Bi, Yaxin

2018-01-01

The next-generation network provides state-of-the-art access-independent services over converged mobile and fixed networks. Security in the converged network environment is a major challenge. Traditional packet and protocol-based intrusion detection techniques cannot be used in next-generation networks due to slow throughput, low accuracy and their inability to inspect encrypted payload. An alternative solution for protection of next-generation networks is to use network flow records for detection of malicious activity in the network traffic. The network flow records are independent of access networks and user applications. In this paper, we propose a two-stage flow-based intrusion detection system for next-generation networks. The first stage uses an enhanced unsupervised one-class support vector machine which separates malicious flows from normal network traffic. The second stage uses a self-organizing map which automatically groups malicious flows into different alert clusters. We validated the proposed approach on two flow-based datasets and obtained promising results.

A two-stage flow-based intrusion detection model for next-generation networks

PubMed Central

2018-01-01

The next-generation network provides state-of-the-art access-independent services over converged mobile and fixed networks. Security in the converged network environment is a major challenge. Traditional packet and protocol-based intrusion detection techniques cannot be used in next-generation networks due to slow throughput, low accuracy and their inability to inspect encrypted payload. An alternative solution for protection of next-generation networks is to use network flow records for detection of malicious activity in the network traffic. The network flow records are independent of access networks and user applications. In this paper, we propose a two-stage flow-based intrusion detection system for next-generation networks. The first stage uses an enhanced unsupervised one-class support vector machine which separates malicious flows from normal network traffic. The second stage uses a self-organizing map which automatically groups malicious flows into different alert clusters. We validated the proposed approach on two flow-based datasets and obtained promising results. PMID:29329294

What do firefighters desire from the next generation of personal protective equipment? Outcomes from an international survey

PubMed Central

LEE, Joo-Young; PARK, Joonhee; PARK, Huiju; COCA, Aitor; KIM, Jung-Hyun; TAYLOR, Nigel A.S.; SON, Su-Young; TOCHIHARA, Yutaka

2015-01-01

The purpose of this study was to investigate smart features required for the next generation of personal protective equipment (PPE) for firefighters in Australia, Korea, Japan, and the USA. Questionnaire responses were obtained from 167 Australian, 351 Japanese, 413 Korean, and 763 U.S. firefighters (1,611 males and 61 females). Preferences concerning smart features varied among countries, with 27% of Korean and 30% of U.S. firefighters identifying ‘a location monitoring system’ as the most important element. On the other hand, 43% of Japanese firefighters preferred ‘an automatic body cooling system’ while 21% of the Australian firefighters selected equally ‘an automatic body cooling system’ and ‘a wireless communication system’. When asked to rank these elements in descending priority, responses across these countries were very similar with the following items ranked highest: ‘a location monitoring system’, ‘an automatic body cooling system’, ‘a wireless communication system’, and ‘a vision support system’. The least preferred elements were ‘an automatic body warming system’ and ‘a voice recording system’. No preferential relationship was apparent for age, work experience, gender or anthropometric characteristics. These results have implications for the development of the next generation of PPE along with the international standardisation of the smart PPE. PMID:26027710

Next-generation Surface Enhanced Raman Scattering (SERS) Substrates for Hazard Detection

DTIC Science & Technology

2012-09-01

Next-generation Surface Enhanced Raman Scattering (SERS) Substrates for Hazard Detection by Mikella E. Farrell, Ellen L. Holthoff and Paul M...Surface Enhanced Raman Scattering (SERS) Substrates for Hazard Detection Mikella E. Farrell, Ellen L. Holthoff and Paul M. Pellegrino Sensors and...DD-MM-YYYY) September 2012 2. REPORT TYPE Reprint 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Next-generation Surface Enhanced Raman

Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery

PubMed Central

2018-01-01

Paclitaxel and docetaxel are among the most widely used chemotherapeutic drugs against various types of cancer. However, these drugs cause undesirable side effects as well as drug resistance. Therefore, it is essential to develop next-generation taxoid anticancer agents with better pharmacological properties and improved activity especially against drug-resistant and metastatic cancers. The SAR studies by the authors have led to the development of numerous highly potent novel second- and third-generation taxoids with systematic modifications at the C-2, C-10, and C-3′ positions. The third-generation taxoids showed virtually no difference in potency against drug-resistant and drug-sensitive cell lines. Some of the next-generation taxoids also exhibited excellent potency against cancer stem cells. This account summarizes concisely investigations into taxoids over 25 years based on a strong quest for the discovery and development of efficacious next-generation taxoids. Discussed herein are SAR studies on different types of taxoids, a common pharmacophore proposal for microtubule-stabilizing anticancer agents and its interesting history, the identification of the paclitaxel binding site and its bioactive conformation, characteristics of the next-generation taxoids in cancer cell biology, including new aspects of their mechanism of action, and the highly efficacious tumor-targeted drug delivery of potent next-generation taxoids. PMID:29468872

ACES: An Enabling Technology for Next Generation Space Transportation

NASA Astrophysics Data System (ADS)

Crocker, Andrew M.; Wuerl, Adam M.; Andrews, Jason E.; Andrews, Dana G.

2004-02-01

Andrews Space has developed the ``Alchemist'' Air Collection and Enrichment System (ACES), a dual-mode propulsion system that enables safe, economical launch systems that take off and land horizontally. Alchemist generates liquid oxygen through separation of atmospheric air using the refrigeration capacity of liquid hydrogen. The key benefit of Alchemist is that it minimizes vehicle takeoff weight. All internal and NASA-funded activities have shown that ACES, previously proposed for hypersonic combined cycle RLVs, is a higher payoff, lower-risk technology if LOX generation is performed while the vehicle cruises subsonically. Andrews Space has developed the Alchemist concept from a small system study to viable Next Generation launch system technology, conducting not only feasibility studies but also related hardware tests, and it has planned a detailed risk reduction program which employs an experienced, proven contractor team. Andrews also has participated in preliminary studies of an evolvable Next Generation vehicle architecture-enabled by Alchemist ACES-which could meet civil, military, and commercial space requirements within two decades.

A closer look at the quadruply lensed quasar PSOJ0147: spectroscopic redshifts and microlensing effect

NASA Astrophysics Data System (ADS)

Lee, Chien-Hsiu

2018-04-01

I present a timely spectroscopic follow-up of the newly discovered, quadruply lensed quasar PSOJ0147 from the Pan-STARRS 1 survey. The newly acquired optical spectra with GMOS onboard the Gemini North Telescope allow us to pin down the redshifts of both the foreground lensing galaxy and the background lensed quasar to be z = 0.572 and 2.341, providing a firm basis for cosmography with future high-cadence photometric monitoring. I also inspect difference spectra from two of the quasar images, revealing the microlensing effect. Long-term spectroscopic follow-ups will shed lights on the structure of the active galactic nucleus and its environment.

The different origins of high- and low-ionization broad emission lines revealed by gravitational microlensing in the Einstein cross

NASA Astrophysics Data System (ADS)

Braibant, L.; Hutsemékers, D.; Sluse, D.; Anguita, T.

2016-07-01

We investigate the kinematics and ionization structure of the broad emission line region of the gravitationally lensed quasar QSO2237+0305 (the Einstein cross) using differential microlensing in the high- and low-ionization broad emission lines. We combine visible and near-infrared spectra of the four images of the lensed quasar and detect a large-amplitude microlensing effect distorting the high-ionization CIV and low-ionization Hα line profiles in image A. While microlensing only magnifies the red wing of the Balmer line, it symmetrically magnifies the wings of the CIV emission line. Given that the same microlensing pattern magnifies both the high- and low-ionization broad emission line regions, these dissimilar distortions of the line profiles suggest that the high- and low-ionization regions are governed by different kinematics. Since this quasar is likely viewed at intermediate inclination, we argue that the differential magnification of the blue and red wings of Hα favors a flattened, virialized, low-ionization region whereas the symmetric microlensing effect measured in CIV can be reproduced by an emission line formed in a polar wind, without the need of fine-tuned caustic configurations. Based on observations made with the ESO-VLT, Paranal, Chile; Proposals 076.B-0197 and 076.B-0607 (PI: Courbin).

Precision medicine for cancer with next-generation functional diagnostics.

PubMed

Friedman, Adam A; Letai, Anthony; Fisher, David E; Flaherty, Keith T

2015-12-01

Precision medicine is about matching the right drugs to the right patients. Although this approach is technology agnostic, in cancer there is a tendency to make precision medicine synonymous with genomics. However, genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies. Recently, several 'next-generation' functional diagnostic technologies have been reported, including novel methods for tumour manipulation, molecularly precise assays of tumour responses and device-based in situ approaches; these address the limitations of the older generation of chemosensitivity tests. The promise of these new technologies suggests a future diagnostic strategy that integrates functional testing with next-generation sequencing and immunoprofiling to precisely match combination therapies to individual cancer patients.

Next Generation Natural Gas Vehicle (NGNGV) program brochure

DOT National Transportation Integrated Search

2000-10-26

The U.S. Department of Energys (DOE) Office of Transportation Technologies (OTT), is responding to these national concerns. OTT has identified the development of next-generation natural gas vehicles as a strategy to reduce oil imports, vehicle pol...

One or more bound planets per Milky Way star from microlensing observations.

PubMed

Cassan, A; Kubas, D; Beaulieu, J-P; Dominik, M; Horne, K; Greenhill, J; Wambsganss, J; Menzies, J; Williams, A; Jørgensen, U G; Udalski, A; Bennett, D P; Albrow, M D; Batista, V; Brillant, S; Caldwell, J A R; Cole, A; Coutures, Ch; Cook, K H; Dieters, S; Prester, D Dominis; Donatowicz, J; Fouqué, P; Hill, K; Kains, N; Kane, S; Marquette, J-B; Martin, R; Pollard, K R; Sahu, K C; Vinter, C; Warren, D; Watson, B; Zub, M; Sumi, T; Szymański, M K; Kubiak, M; Poleski, R; Soszynski, I; Ulaczyk, K; Pietrzyński, G; Wyrzykowski, L

2012-01-11

Most known extrasolar planets (exoplanets) have been discovered using the radial velocity or transit methods. Both are biased towards planets that are relatively close to their parent stars, and studies find that around 17-30% (refs 4, 5) of solar-like stars host a planet. Gravitational microlensing, on the other hand, probes planets that are further away from their stars. Recently, a population of planets that are unbound or very far from their stars was discovered by microlensing. These planets are at least as numerous as the stars in the Milky Way. Here we report a statistical analysis of microlensing data (gathered in 2002-07) that reveals the fraction of bound planets 0.5-10 AU (Sun-Earth distance) from their stars. We find that 17(+6)(-9)% of stars host Jupiter-mass planets (0.3-10 M(J), where M(J) = 318 M(⊕) and M(⊕) is Earth's mass). Cool Neptunes (10-30 M(⊕)) and super-Earths (5-10 M(⊕)) are even more common: their respective abundances per star are 52(+22)(-29)% and 62(+35)(-37)%. We conclude that stars are orbited by planets as a rule, rather than the exception.

Next generation control system for reflexive aerostructures

NASA Astrophysics Data System (ADS)

Maddux, Michael R.; Meents, Elizabeth P.; Barnell, Thomas J.; Cable, Kristin M.; Hemmelgarn, Christopher; Margraf, Thomas W.; Havens, Ernie

2010-04-01

Cornerstone Research Group Inc. (CRG) has developed and demonstrated a composite structural solution called reflexive composites for aerospace applications featuring CRG's healable shape memory polymer (SMP) matrix. In reflexive composites, an integrated structural health monitoring (SHM) system autonomously monitors the structural health of composite aerospace structures, while integrated intelligent controls monitor data from the SHM system to characterize damage and initiate healing when damage is detected. Development of next generation intelligent controls for reflexive composites were initiated for the purpose of integrating prognostic health monitoring capabilities into the reflexive composite structural solution. Initial efforts involved data generation through physical inspections and mechanical testing. Compression after impact (CAI) testing was conducted on composite-reinforced shape memory polymer samples to induce damage and investigate the effectiveness of matrix healing on mechanical performance. Non-destructive evaluation (NDE) techniques were employed to observe and characterize material damage. Restoration of mechanical performance was demonstrated through healing, while NDE data showed location and size of damage and verified mitigation of damage post-healing. Data generated was used in the development of next generation reflexive controls software. Data output from the intelligent controls could serve as input to Integrated Vehicle Health Management (IVHM) systems and Integrated Resilient Aircraft Controls (IRAC). Reflexive composite technology has the ability to reduce maintenance required on composite structures through healing, offering potential to significantly extend service life of aerospace vehicles and reduce operating and lifecycle costs.

Two novel ALK mutations mediate acquired resistance to the next generation ALK inhibitor alectinib

PubMed Central

Katayama, Ryohei; Friboulet, Luc; Koike, Sumie; Lockerman, Elizabeth L.; Khan, Tahsin M.; Gainor, Justin F.; Iafrate, A. John; Takeuchi, Kengo; Taiji, Makoto; Okuno, Yasushi; Fujita, Naoya; Engelman, Jeffrey A.; Shaw, Alice T.

2014-01-01

Purpose The first-generation ALK tyrosine kinase inhibitor (TKI) crizotinib is a standard therapy for patients with ALK-rearranged NSCLC. Several next-generation ALK-TKIs have entered the clinic and have shown promising activity in crizotinib-resistant patients. As patients still relapse even on these next-generation ALK-TKIs, we examined mechanisms of resistance to the next-generation ALK-TKI alectinib and potential strategies to overcome this resistance. Experimental Design We established a cell line model of alectinib resistance, and analyzed a resistant tumor specimen from a patient who had relapsed on alectinib. We developed Ba/F3 models harboring alectinib-resistant ALK mutations and evaluated the potency of other next-generation ALK-TKIs in these models. We tested the antitumor activity of the next-generation ALK-TKI ceritinib in the patient with acquired resistance to alectinib. To elucidate structure-activity-relationships of ALK mutations, we performed computational thermodynamic simulation with MP-CAFEE. Results We identified a novel V1180L gatekeeper mutation from the cell line model and a second novel I1171T mutation from the patient who developed resistance to alectinib. Both ALK mutations conferred resistance to alectinib as well as to crizotinib, but were sensitive to ceritinib and other next-generation ALK-TKIs. Treatment of the patient with ceritinib led to a marked response. Thermodynamics simulation suggests that both mutations lead to distinct structural alterations that decrease the binding affinity with alectinib. Conclusions We have identified two novel ALK mutations arising after alectinib exposure which are sensitive to other next generation ALK-TKIs. The ability of ceritinib to overcome alectinib-resistance mutations suggests a potential role for sequential therapy with multiple next-generation ALK-TKIs. PMID:25228534

Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.

PubMed

Katayama, Ryohei; Friboulet, Luc; Koike, Sumie; Lockerman, Elizabeth L; Khan, Tahsin M; Gainor, Justin F; Iafrate, A John; Takeuchi, Kengo; Taiji, Makoto; Okuno, Yasushi; Fujita, Naoya; Engelman, Jeffrey A; Shaw, Alice T

2014-11-15

The first-generation ALK tyrosine kinase inhibitor (TKI) crizotinib is a standard therapy for patients with ALK-rearranged non-small cell lung cancer (NSCLC). Several next-generation ALK-TKIs have entered the clinic and have shown promising activity in crizotinib-resistant patients. As patients still relapse even on these next-generation ALK-TKIs, we examined mechanisms of resistance to the next-generation ALK-TKI alectinib and potential strategies to overcome this resistance. We established a cell line model of alectinib resistance, and analyzed a resistant tumor specimen from a patient who had relapsed on alectinib. We developed Ba/F3 models harboring alectinib-resistant ALK mutations and evaluated the potency of other next-generation ALK-TKIs in these models. We tested the antitumor activity of the next-generation ALK-TKI ceritinib in the patient with acquired resistance to alectinib. To elucidate structure-activity relationships of ALK mutations, we performed computational thermodynamic simulation with MP-CAFEE. We identified a novel V1180L gatekeeper mutation from the cell line model and a second novel I1171T mutation from the patient who developed resistance to alectinib. Both ALK mutations conferred resistance to alectinib as well as to crizotinib, but were sensitive to ceritinib and other next-generation ALK-TKIs. Treatment of the patient with ceritinib led to a marked response. Thermodynamics simulation suggests that both mutations lead to distinct structural alterations that decrease the binding affinity with alectinib. We have identified two novel ALK mutations arising after alectinib exposure that are sensitive to other next-generation ALK-TKIs. The ability of ceritinib to overcome alectinib-resistance mutations suggests a potential role for sequential therapy with multiple next-generation ALK-TKIs. ©2014 American Association for Cancer Research.

Revived STIS. II. Properties of Stars in the Next Generation Spectral Library

NASA Technical Reports Server (NTRS)

Heap, Sara R.; Lindler, D.

2010-01-01

Spectroscopic surveys of galaxies at high redshift will bring the rest-frame ultraviolet into view of large, ground-based telescopes. The UV-blue spectral region is rich in diagnostics, but these diagnostics have not yet been calibrated in terms of the properties of the responsible stellar population(s). Such calibrations are now possible with Hubble's Next Generation Spectral Library (NGSL). The NGSL contains UV-optical spectra (0.2 - 1.0 microns) of 374 stars having a wide range in temperature, luminosity, and metallicity. We will describe our work to derive basic stellar parameters from NGSL spectra using modern model spectra and to use these stellar parameters to develop UV-blue spectral diagnostics.

Educating the next generation of nature entrepreneurs

Treesearch

Judith C. Jobse; Loes Witteveen; Judith Santegoets; Daan van der Linde

2015-01-01

With this paper, it is illustrated that a focus on entrepreneurship training in the nature and wilderness sector is relevant for diverse organisations and situations. The first curricula on nature entrepreneurship are currently being developed. In this paper the authors describe a project that focusses on educating the next generation of nature entrepreneurs, reflect...

Next Generation Distributed Computing for Cancer Research

PubMed Central

Agarwal, Pankaj; Owzar, Kouros

2014-01-01

Advances in next generation sequencing (NGS) and mass spectrometry (MS) technologies have provided many new opportunities and angles for extending the scope of translational cancer research while creating tremendous challenges in data management and analysis. The resulting informatics challenge is invariably not amenable to the use of traditional computing models. Recent advances in scalable computing and associated infrastructure, particularly distributed computing for Big Data, can provide solutions for addressing these challenges. In this review, the next generation of distributed computing technologies that can address these informatics problems is described from the perspective of three key components of a computational platform, namely computing, data storage and management, and networking. A broad overview of scalable computing is provided to set the context for a detailed description of Hadoop, a technology that is being rapidly adopted for large-scale distributed computing. A proof-of-concept Hadoop cluster, set up for performance benchmarking of NGS read alignment, is described as an example of how to work with Hadoop. Finally, Hadoop is compared with a number of other current technologies for distributed computing. PMID:25983539

Next generation distributed computing for cancer research.

PubMed

Agarwal, Pankaj; Owzar, Kouros

2014-01-01

Advances in next generation sequencing (NGS) and mass spectrometry (MS) technologies have provided many new opportunities and angles for extending the scope of translational cancer research while creating tremendous challenges in data management and analysis. The resulting informatics challenge is invariably not amenable to the use of traditional computing models. Recent advances in scalable computing and associated infrastructure, particularly distributed computing for Big Data, can provide solutions for addressing these challenges. In this review, the next generation of distributed computing technologies that can address these informatics problems is described from the perspective of three key components of a computational platform, namely computing, data storage and management, and networking. A broad overview of scalable computing is provided to set the context for a detailed description of Hadoop, a technology that is being rapidly adopted for large-scale distributed computing. A proof-of-concept Hadoop cluster, set up for performance benchmarking of NGS read alignment, is described as an example of how to work with Hadoop. Finally, Hadoop is compared with a number of other current technologies for distributed computing.

Sequencing technologies - the next generation.

PubMed

Metzker, Michael L

2010-01-01

Demand has never been greater for revolutionary technologies that deliver fast, inexpensive and accurate genome information. This challenge has catalysed the development of next-generation sequencing (NGS) technologies. The inexpensive production of large volumes of sequence data is the primary advantage over conventional methods. Here, I present a technical review of template preparation, sequencing and imaging, genome alignment and assembly approaches, and recent advances in current and near-term commercially available NGS instruments. I also outline the broad range of applications for NGS technologies, in addition to providing guidelines for platform selection to address biological questions of interest.

Constraining the geometry and kinematics of the quasar broad emission line region using gravitational microlensing. I. Models and simulations

NASA Astrophysics Data System (ADS)

Braibant, L.; Hutsemékers, D.; Sluse, D.; Goosmann, R.

2017-11-01

Recent studies have shown that line profile distortions are commonly observed in gravitationally lensed quasar spectra. Often attributed to microlensing differential magnification, line profile distortions can provide information on the geometry and kinematics of the broad emission line region (BLR) in quasars. We investigate the effect of gravitational microlensing on quasar broad emission line profiles and their underlying continuum, combining the emission from simple representative BLR models with generic microlensing magnification maps. Specifically, we considered Keplerian disk, polar, and equatorial wind BLR models of various sizes. The effect of microlensing has been quantified with four observables: μBLR, the total magnification of the broad emission line; μcont, the magnification of the underlying continuum; as well as red/blue, RBI and wings/core, WCI, indices that characterize the line profile distortions. The simulations showed that distortions of line profiles, such as those recently observed in lensed quasars, can indeed be reproduced and attributed to the differential effect of microlensing on spatially separated regions of the BLR. While the magnification of the emission line μBLR sets an upper limit on the BLR size and, similarly, the magnification of the continuum μcont sets an upper limit on the size of the continuum source, the line profile distortions mainly depend on the BLR geometry and kinematics. We thus built (WCI,RBI) diagrams that can serve as diagnostic diagrams to discriminate between the various BLR models on the basis of quantitative measurements. It appears that a strong microlensing effect puts important constraints on the size of the BLR and on its distance to the high-magnification caustic. In that case, BLR models with different geometries and kinematics are more prone to produce distinctive line profile distortions for a limited number of caustic configurations, which facilitates their discrimination. When the microlensing

Using Adaptive Optics Follow-up to Characterize Microlensing Exoplanets

NASA Astrophysics Data System (ADS)

Henderson, Calen; Beichman, Charles; Shvartzvald, Yossi

2018-01-01

The mass and distance of a microlens are degenerate, thus requiring at least two relations to yield a unique solution. Measuring the finite-source effect from the light curve helps provide one mass-distance relation for the lens system. Currently, the primary avenue for establishing a second relation and thus uniquely solving for the mass and distance of the lens is by measuring the microlens parallax. One specific implementation is the satellite parallax technique, which involves taking observations simultaneously from two locations separated by a significant fraction of an AU, and which has been employed by Spitzer and K2's Campaign 9, transforming this methodology from a cottage industry to a booming economy. However, the majority of microlensing exoplanets to be discovered in the coming decades, up to and including the detections predicted for WFIRST, will not have a measurement of the satellite parallax, requiring another avenue for converting microlensing observables into physical parameters. Enter the lens flux characterization technique, through which a microlensing target is observed with a high-resolution facility, facilitating a constraint on the flux from the lens system. This yields a third mass-distance relation for the lens and can be combined with that from the detection of finite-source effects and/or the microlens parallax to determine the mass of the lens system as well as its distance from Earth. I will highlight recent programs using NIRC2 on Keck that are designed to make lens flux measurements for a myriad of exoplanetary lenses, including: (A) systems with high blend flux, which adaptive optics is perfectly suited to resolve; (B) systems with high relative lens-source proper motion; (C) free-floating planet candidates; and (D) bound exoplanets.

Next-generation sequencing for endocrine cancers: Recent advances and challenges.

PubMed

Suresh, Padmanaban S; Venkatesh, Thejaswini; Tsutsumi, Rie; Shetty, Abhishek

2017-05-01

Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Microarray analyses have provided gene signatures from many cells, tissues, and organs that can differentiate healthy states from diseased ones, and even show patterns that correlate with stages of a disease. Microarray data can also elucidate the responses of endocrine tumors to therapeutic treatments. The rapid progress in next-generation sequencing methods has overcome many of the initial challenges of these technologies, and their advantages over microarray techniques have enabled them to emerge as valuable aids for clinical research applications (prognosis, identification of drug targets, etc.). A comprehensive review describing the recent advances in next-generation sequencing methods and their application in the evaluation of endocrine and endocrine-related cancers is lacking. The main purpose of this review is to illustrate the concepts that collectively constitute our current view of the possibilities offered by next-generation sequencing technological platforms, challenges to relevant applications, and perspectives on the future of clinical genetic testing of patients with endocrine tumors. We focus on recent discoveries in the use of next-generation sequencing methods for clinical diagnosis of endocrine tumors in patients and conclude with a discussion on persisting challenges and future objectives.

Investigation of Next-Generation Earth Radiation Budget Radiometry

NASA Technical Reports Server (NTRS)

Coffey, Katherine L.; Mahan, J. R.

1999-01-01

The current effort addresses two issues important to the research conducted by the Thermal Radiation Group at Virginia Tech. The first research topic involves the development of a method which can properly model the diffraction of radiation as it enters an instrument aperture. The second topic involves the study of a potential next-generation space-borne radiometric instrument concept. Presented are multiple modeling efforts to describe the diffraction of monochromatic radiant energy passing through an aperture for use in the Monte-Carlo ray-trace environment. Described in detail is a deterministic model based upon Heisenberg's uncertainty principle and the particle theory of light. This method is applicable to either Fraunhofer or Fresnel diffraction situations, but is incapable of predicting the secondary fringes in a diffraction pattern. Also presented is a second diffraction model, based on the Huygens-Fresnel principle with a correcting obliquity factor. This model is useful for predicting Fraunhofer diffraction, and can predict the secondary fringes because it keeps track of phase. NASA is planning for the next-generation of instruments to follow CERES (Clouds and the Earth's Radiant Energy System), an instrument which measures components of the Earth's radiant energy budget in three spectral bands. A potential next-generation concept involves modification of the current CERES instrument to measure in a larger number of wavelength bands. This increased spectral partitioning would be achieved by the addition of filters and detectors to the current CERES geometry. The capacity of the CERES telescope to serve for this purpose is addressed in this thesis.

An efficient method to compute microlensed light curves for point sources

NASA Technical Reports Server (NTRS)

Witt, Hans J.

1993-01-01

We present a method to compute microlensed light curves for point sources. This method has the general advantage that all microimages contributing to the light curve are found. While a source moves along a straight line, all micro images are located either on the primary image track or on the secondary image tracks (loops). The primary image track extends from - infinity to + infinity and is made of many sequents which are continuously connected. All the secondary image tracks (loops) begin and end on the lensing point masses. The method can be applied to any microlensing situation with point masses in the deflector plane, even for the overcritical case and surface densities close to the critical. Furthermore, we present general rules to evaluate the light curve for a straight track arbitrary placed in the caustic network of a sample of many point masses.

New limits on primordial black hole dark matter from an analysis of Kepler source microlensing data.

PubMed

Griest, Kim; Cieplak, Agnieszka M; Lehner, Matthew J

2013-11-01

We present new limits on the allowed masses of a dark matter (DM) halo consisting of primordial black holes (PBH) (or any other massive compact halo object). We analyze two years of data from the Kepler satellite, searching for short-duration bumps caused by gravitational microlensing. After removing background events consisting of variable stars, flare events, and comets or asteroids moving through the Kepler field, we find no microlensing candidates. We measure the efficiency of our selection criteria by adding millions of simulated microlensing lensing events into the Kepler light curves. We find that PBH DM with masses in the range 2 × 10(-9) M[Symbol: see text] to 10(-7)M[Symbol: see text] cannot make up the entirety of the DM in the Milky Way. At the low-mass end, this decreases the allowed mass range by more than an order of magnititude.

Gravitational Lensing and Microlensing in Clusters: Clusters as Dark Matter Telescopes

NASA Astrophysics Data System (ADS)

Safonova, Margarita

2018-04-01

Gravitational lensing is brightening of background objects due to deflection of light by foreground sources. Rich clusters of galaxies are very effective lenses because they are centrally concentrated. Such natural Gravitational Telescopes provide us with strongly magnified galaxies at high redshifts otherwise too faint to be detected or analyzed. With a lensing boost, we can study galaxies shining at the end of the “Dark Ages”. We propose to exploit the opportunity provided by the large field of view and depth, to search for sources magnified by foreground clusters in the vicinity of the cluster critical curves, where enhancements can be of several tens in brightness. Another aspect is microlensing (ML), where we would like to continue our survey of a number of Galactic globular clusters over time-scales of weeks to years to search for ML events from planets to hypothesized central intermediate-mass black holes (IMBH).

Next Generation HeliMag UXO Mapping Technology

DTIC Science & Technology

2010-01-01

Ancillary instrumentation records aircraft height above ground and attitude. A fluxgate magnetometer is used to allow for aeromagnetic compensation of... Magnetometer System WWII World War II WAA wide area assessment ACKNOWLEDGEMENTS This Next Generation HeliMag Unexploded Ordnance (UXO) Mapping...for deployment of seven total-field magnetometers on a Kevlar reinforced boom mounted on a Bell 206L helicopter. The objectives of this

Small Next-Generation Atmospheric Probe (SNAP) Concept

NASA Technical Reports Server (NTRS)

Sayanagi, K. M.; Dillman, R. A.; Simon, A. A.; Atkinson, D. H.; Wong, M. H.; Spilker, T. R.; Saikia, S.; Li, J.; Hope, D.

2017-01-01

We present the Small Next-Generation Atmospheric Probe (SNAP) as a secondary payload concept for future missions to giant planets. As a case study, we examine the advantages, cost and risk of adding SNAP to the future Uranus Orbiter and Probe flag-ship mission; in combination with the missions main probe, SNAP would perform atmospheric in-situ measurements at a second location.

NGSS and the Next Generation of Science Teachers

ERIC Educational Resources Information Center

Bybee, Rodger W.

2014-01-01

This article centers on the "Next Generation Science Standards" (NGSS) and their implications for teacher development, particularly at the undergraduate level. After an introduction to NGSS and the influence of standards in the educational system, the article addresses specific educational shifts--interconnecting science and engineering…

78 FR 52941 - Cooperative Research and Development Agreement: Next Generation Arctic Navigational Safety...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... Development Agreement: Next Generation Arctic Navigational Safety Information System AGENCY: Coast Guard, DHS... technology approach to the ``Next Generation Arctic Maritime Navigational Safety Information System,'' which... their voyage risks, as they transit the remote and hostile waters of the U.S. Arctic Exclusive Economic...

Next-generation mid-infrared sources

NASA Astrophysics Data System (ADS)

Jung, D.; Bank, S.; Lee, M. L.; Wasserman, D.

2017-12-01

to provide a survey of the current state of the art for mid-IR sources, but instead looks primarily to provide a picture of potential next-generation optical and optoelectronic materials systems for mid-IR light generation.

Microlensing Constraints on the Mass of Single Stars from HST Astrometric Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kains, N.; Calamida, A.; Sahu, K. C.

Here, we report on the first results from a large-scale observing campaign aiming to use astrometric microlensing to detect and place limits on the mass of single objects, including stellar remnants. We used the Hubble Space Telescope to monitor stars near the Galactic Center for three years, and we measured the brightness and positions of ~2 million stars at each observing epoch. In addition to this, we monitored the same pointings using the VIMOS imager on the Very Large Telescope. The stars we monitored include several bright microlensing events observed from the ground by the OGLE collaboration. In this paper,more » we present the analysis of our photometric and astrometric measurements for six of these events, and derive mass constraints for the lens in each of them. Although these constraints are limited by the photometric precision of ground-based data, and our ability to determine the lens distance, we were able to constrain the size of the Einstein ring radius thanks to our precise astrometric measurements—the first routine measurements of this type from a large-scale observing program. In conclusion, this demonstrates the power of astrometric microlensing as a tool to constrain the masses of stars, stellar remnants, and, in the future, extrasolar planets, using precise ground- and space-based observations.« less

Microlensing Constraints on the Mass of Single Stars from HST Astrometric Measurements

DOE PAGES

Kains, N.; Calamida, A.; Sahu, K. C.; ...

2017-07-14

Here, we report on the first results from a large-scale observing campaign aiming to use astrometric microlensing to detect and place limits on the mass of single objects, including stellar remnants. We used the Hubble Space Telescope to monitor stars near the Galactic Center for three years, and we measured the brightness and positions of ~2 million stars at each observing epoch. In addition to this, we monitored the same pointings using the VIMOS imager on the Very Large Telescope. The stars we monitored include several bright microlensing events observed from the ground by the OGLE collaboration. In this paper,more » we present the analysis of our photometric and astrometric measurements for six of these events, and derive mass constraints for the lens in each of them. Although these constraints are limited by the photometric precision of ground-based data, and our ability to determine the lens distance, we were able to constrain the size of the Einstein ring radius thanks to our precise astrometric measurements—the first routine measurements of this type from a large-scale observing program. In conclusion, this demonstrates the power of astrometric microlensing as a tool to constrain the masses of stars, stellar remnants, and, in the future, extrasolar planets, using precise ground- and space-based observations.« less

Next Generation Space Telescope

NASA Technical Reports Server (NTRS)

Mather, John; Stockman, H. S.; Fisher, Richard R. (Technical Monitor)

2000-01-01

The Next Generation Space Telescope (NGST), planned for launch in 2009, will be an 8-m class radiatively cooled infrared telescope at the Lagrange point L2. It will cover the wavelength range from 0.6 to 28 microns with cameras and spectrometers, to observe the first luminous objects after the Big Bang, and the formation, growth, clustering, and evolution of galaxies, stars, and protoplanetary clouds, leading to better understanding of our own Origins. It will seek evidence of the cosmic dark matter through its gravitational effects. With an aperture three times greater than the Hubble Space Telescope, it will provide extraordinary advances in capabilities and enable the discovery of many new phenomena. It is a joint project of the NASA, ESA, and CSA, and scientific operations will be provided by the Space Telescope Science Institute.

Emerging Definition of Next-Generation of Aeronautical Communications

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.

2006-01-01

Aviation continues to experience rapid growth. In regions such as the United States and Europe air traffic congestion is constraining operations, leading to major new efforts to develop methodologies and infrastructures to enable continued aviation growth through transformational air traffic management systems. Such a transformation requires better communications linking airborne and ground-based elements. Technologies for next-generation communications, the required capacities, frequency spectrum of operation, network interconnectivity, and global interoperability are now receiving increased attention. A number of major planning and development efforts have taken place or are in process now to define the transformed airspace of the future. These activities include government and industry led efforts in the United States and Europe, and by international organizations. This paper will review the features, approaches, and activities of several representative planning and development efforts, and identify the emerging global consensus on requirements of next generation aeronautical communications systems for air traffic control.

Galaxy two-point covariance matrix estimation for next generation surveys

NASA Astrophysics Data System (ADS)

Howlett, Cullan; Percival, Will J.

2017-12-01

We perform a detailed analysis of the covariance matrix of the spherically averaged galaxy power spectrum and present a new, practical method for estimating this within an arbitrary survey without the need for running mock galaxy simulations that cover the full survey volume. The method uses theoretical arguments to modify the covariance matrix measured from a set of small-volume cubic galaxy simulations, which are computationally cheap to produce compared to larger simulations and match the measured small-scale galaxy clustering more accurately than is possible using theoretical modelling. We include prescriptions to analytically account for the window function of the survey, which convolves the measured covariance matrix in a non-trivial way. We also present a new method to include the effects of super-sample covariance and modes outside the small simulation volume which requires no additional simulations and still allows us to scale the covariance matrix. As validation, we compare the covariance matrix estimated using our new method to that from a brute-force calculation using 500 simulations originally created for analysis of the Sloan Digital Sky Survey Main Galaxy Sample. We find excellent agreement on all scales of interest for large-scale structure analysis, including those dominated by the effects of the survey window, and on scales where theoretical models of the clustering normally break down, but the new method produces a covariance matrix with significantly better signal-to-noise ratio. Although only formally correct in real space, we also discuss how our method can be extended to incorporate the effects of redshift space distortions.

Strong chromatic microlensing in HE0047–1756 and SDSS1155+6346

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rojas, K.; Motta, V.; Mediavilla, E.

2014-12-10

We use spectra of the double-lensed quasars HE0047–1756 and SDSS1155+6346 to study their unresolved structure through the impact of microlensing. There is no significant evidence of microlensing in the emission line profiles except for the Lyα line of SDSS1155+6346, which shows strong differences in the shapes for images A and B. However, the continuum of the B image spectrum in SDSS1155+6346 is strongly contaminated by the lens galaxy, and these differences should be considered with caution. Using the flux ratios of the emission lines for image pairs as a baseline to remove macro-magnification and extinction, we have detected strong chromaticmore » microlensing in the continuum measured by CASTLES (www.cfa.harvard.edu/castles/) in both lens systems, with amplitudes 0.09(λ16000) ≲ |Δm| ≲ 0.8(λ5439) for HE0047–1756, and 0.2(λ16000) ≲ |Δm| ≲ 0.8(λ5439) for SDSS1155+6346. Using magnification maps to simulate microlensing and modeling the accretion disk as a Gaussian source (I ∝ exp(–R {sup 2}/2r {sub s}{sup 2})) of size r {sub s} ∝ λ {sup p}, we find r {sub s} = 2.5{sub −1.4}{sup +3.0} √(M/0.3M{sub ⊙}) lt-day and p = 2.3 ± 0.8 at the rest frame for λ = 2045 for HE0047–1756 (log prior) and r {sub s} = 5.5{sub −3.3}{sup +8.2} √(M/0.3M{sub ⊙}) lt-day and p = 1.5 ± 0.6 at the rest frame of λ = 1398 for SDSS1155+6346 (log prior). Contrary to other studied lens systems, the chromaticity detected in HE0047–1756 and SDSS1155+6346 is large enough to fulfill the thin disk prediction. The inferred sizes, however, are very large compared to the predictions of this model, especially in the case of SDSS1155+6346.« less

Adaptive Practice: Next Generation Evidence-Based Practice in Digital Environments.

PubMed

Kennedy, Margaret Ann

2016-01-01

Evidence-based practice in nursing is considered foundational to safe, competent care. To date, rigid traditional perceptions of what constitutes 'evidence' have constrained the recognition and use of practice-based evidence and the exploitation of novel forms of evidence from data rich environments. Advancements such as the conceptualization of clinical intelligence, the prevalence of increasingly sophisticated digital health information systems, and the advancement of the Big Data phenomenon have converged to generate a new contemporary context. In today's dynamic data-rich environments, clinicians have new sources of valid evidence, and need a new paradigm supporting clinical practice that is adaptive to information generated by diverse electronic sources. This opinion paper presents adaptive practice as the next generation of evidence-based practice in contemporary evidence-rich environments and provides recommendations for the next phase of evolution.

Next Generation Sequence Assembly with AMOS

PubMed Central

Treangen, Todd J; Sommer, Dan D; Angly, Florent E; Koren, Sergey; Pop, Mihai

2011-01-01

A Modular Open-Source Assembler (AMOS) was designed to offer a modular approach to genome assembly. AMOS includes a wide range of tools for assembly, including lightweight de novo assemblers Minimus and Minimo, and Bambus 2, a robust scaffolder able to handle metagenomic and polymorphic data. This protocol describes how to configure and use AMOS for the assembly of Next Generation sequence data. Additionally, we provide three tutorial examples that include bacterial, viral, and metagenomic datasets with specific tips for improving assembly quality. PMID:21400694

Next Generation Science Standards: For States, by States

ERIC Educational Resources Information Center

National Academies Press, 2013

2013-01-01

"Next Generation Science Standards" identifies the science all K-12 students should know. These new standards are based on the National Research Council's "A Framework for K-12 Science Education." The National Research Council, the National Science Teachers Association, the American Association for the Advancement of Science,…

Approaches and Strategies in Next Generation Science Learning

ERIC Educational Resources Information Center

Khine, Myint Swe, Ed.; Saleh, Issa M., Ed.

2013-01-01

"Approaches and Strategies in Next Generation Science Learning" examines the challenges involved in the development of modern curriculum models, teaching strategies, and assessments in science education in order to prepare future students in the 21st century economies. This comprehensive collection of research brings together science educators,…

Advanced instrumentation for next-generation aerospace propulsion control systems

NASA Technical Reports Server (NTRS)

Barkhoudarian, S.; Cross, G. S.; Lorenzo, Carl F.

1993-01-01

New control concepts for the next generation of advanced air-breathing and rocket engines and hypersonic combined-cycle propulsion systems are analyzed. The analysis provides a database on the instrumentation technologies for advanced control systems and cross matches the available technologies for each type of engine to the control needs and applications of the other two types of engines. Measurement technologies that are considered to be ready for implementation include optical surface temperature sensors, an isotope wear detector, a brushless torquemeter, a fiberoptic deflectometer, an optical absorption leak detector, the nonintrusive speed sensor, and an ultrasonic triducer. It is concluded that all 30 advanced instrumentation technologies considered can be recommended for further development to meet need of the next generation of jet-, rocket-, and hypersonic-engine control systems.

NASA's Next Generation Launch Technology Program - Strategy and Plans

NASA Technical Reports Server (NTRS)

Hueter, Uwe

2003-01-01

The National Aeronautics and Space Administration established a new program office, Next Generation Launch Technology (NGLT) Program Office, last year to pursue technologies for future space launch systems. NGLT will fund research in key technology areas such as propulsion, launch vehicles, operations and system analyses. NGLT is part of NASA s Integrated Space Technology Plan. The NGLT Program is sponsored by NASA s Office of Aerospace Technology and is part of the Space Launch Initiative theme that includes both NGLT and Orbital Space Plane. NGLT will focus on technology development to increase safety and reliability and reduce overall costs associated with building, flying and maintaining the nation s next-generations of space launch vehicles. These investments will be guided by systems engineering and analysis with a focus on the needs of National customers.

Next Generation Advanced Video Guidance Sensor

NASA Technical Reports Server (NTRS)

Lee, Jimmy; Spencer, Susan; Bryan, Tom; Johnson, Jimmie; Robertson, Bryan

2008-01-01

The first autonomous rendezvous and docking in the history of the U.S. Space Program was successfully accomplished by Orbital Express, using the Advanced Video Guidance Sensor (AVGS) as the primary docking sensor. The United States now has a mature and flight proven sensor technology for supporting Crew Exploration Vehicles (CEV) and Commercial Orbital Transport. Systems (COTS) Automated Rendezvous and Docking (AR&D). AVGS has a proven pedigree, based on extensive ground testing and flight demonstrations. The AVGS on the Demonstration of Autonomous Rendezvous Technology (DART)mission operated successfully in "spot mode" out to 2 km. The first generation rendezvous and docking sensor, the Video Guidance Sensor (VGS), was developed and successfully flown on Space Shuttle flights in 1997 and 1998. Parts obsolescence issues prevent the construction of more AVGS. units, and the next generation sensor must be updated to support the CEV and COTS programs. The flight proven AR&D sensor is being redesigned to update parts and add additional. capabilities for CEV and COTS with the development of the Next, Generation AVGS (NGAVGS) at the Marshall Space Flight Center. The obsolete imager and processor are being replaced with new radiation tolerant parts. In addition, new capabilities might include greater sensor range, auto ranging, and real-time video output. This paper presents an approach to sensor hardware trades, use of highly integrated laser components, and addresses the needs of future vehicles that may rendezvous and dock with the International Space Station (ISS) and other Constellation vehicles. It will also discuss approaches for upgrading AVGS to address parts obsolescence, and concepts for minimizing the sensor footprint, weight, and power requirements. In addition, parts selection and test plans for the NGAVGS will be addressed to provide a highly reliable flight qualified sensor. Expanded capabilities through innovative use of existing capabilities will also be

OGLE-2003-BLG-238: Microlensing Mass Estimate of an Isolated Star

NASA Astrophysics Data System (ADS)

Jiang, Guangfei; DePoy, D. L.; Gal-Yam, A.; Gaudi, B. S.; Gould, A.; Han, C.; Lipkin, Y.; Maoz, D.; Ofek, E. O.; Park, B.-G.; Pogge, R. W.; MuFun Collaboration; Udalski, A.; Kubiak, M.; Szymański, M. K.; Szewczyk, O.; Żebruń, K.; Wyrzykowski, Ł.; Soszyński, I.; Pietrzyński, G.; OGLE Collaboration; Albrow, M. D.; Beaulieu, J.-P.; Caldwell, J. A. R.; Cassan, A.; Coutures, C.; Dominik, M.; Donatowicz, J.; Fouqué, P.; Greenhill, J.; Hill, K.; Horne, K.; Jørgensen, S. F.; Jørgensen, U. G.; Kane, S.; Kubas, D.; Martin, R.; Menzies, J.; Pollard, K. R.; Sahu, K. C.; Wambsganss, J.; Watson, R.; Williams, A.; PLANET Collaboration

2004-12-01

Microlensing is the only known direct method to measure the masses of stars that lack visible companions. In terms of microlensing observables, the mass is given by M=(c2/4G)rEθE and so requires the measurement of both the angular Einstein radius θE and the projected Einstein radius rE. Simultaneous measurement of these two parameters is extremely rare. Here we analyze OGLE-2003-BLG-238, a spectacularly bright (Imin=10.3), high-magnification (Amax=170) microlensing event. Pronounced finite-source effects permit a measurement of θE=650μas. Although the timescale of the event is only tE=38days, one can still obtain weak constraints on the microlens parallax: 4.4AU

Next Generation Science Standards: All Standards, All Students

ERIC Educational Resources Information Center

Lee, Okhee; Miller, Emily C.; Januszyk, Rita

2014-01-01

The Next Generation Science Standards (NGSS) offer a vision of science teaching and learning that presents both learning opportunities and demands for all students, particularly student groups that have traditionally been underserved in science classrooms. The NGSS have addressed issues of diversity and equity from their inception, and the NGSS…

Preparing the Next Generation of Educators for Democracy

ERIC Educational Resources Information Center

Embry-Jenlink, Karen

2018-01-01

In the keynote address of the 42nd annual meeting of the Southeastern Regional Educators Association (SRATE), ATE President Karen Embry-Jenlink examines the critical role of teacher educators in preparing the next generation of citizens and leaders to sustain democracy. Drawing from historic and current events and personal experience,…

Next generation sequence assembly with AMOS.

PubMed

Treangen, Todd J; Sommer, Dan D; Angly, Florent E; Koren, Sergey; Pop, Mihai

2011-03-01

A Modular Open-Source Assembler (AMOS) was designed to offer a modular approach to genome assembly. AMOS includes a wide range of tools for assembly, including the lightweight de novo assemblers Minimus and Minimo, and Bambus 2, a robust scaffolder able to handle metagenomic and polymorphic data. This protocol describes how to configure and use AMOS for the assembly of Next Generation sequence data. Additionally, we provide three tutorial examples that include bacterial, viral, and metagenomic datasets with specific tips for improving assembly quality. © 2011 by John Wiley & Sons, Inc.

Fiber to the home: next generation network

NASA Astrophysics Data System (ADS)

Yang, Chengxin; Guo, Baoping

2006-07-01

Next generation networks capable of carrying converged telephone, television (TV), very high-speed internet, and very high-speed bi-directional data services (like video-on-demand (VOD), Game etc.) strategy for Fiber To The Home (FTTH) is presented. The potential market is analyzed. The barriers and some proper strategy are also discussed. Several technical problems like various powering methods, optical fiber cables, and different network architecture are discussed too.

Next-Generation Sequencing in the Mycology Lab.

PubMed

Zoll, Jan; Snelders, Eveline; Verweij, Paul E; Melchers, Willem J G

New state-of-the-art techniques in sequencing offer valuable tools in both detection of mycobiota and in understanding of the molecular mechanisms of resistance against antifungal compounds and virulence. Introduction of new sequencing platform with enhanced capacity and a reduction in costs for sequence analysis provides a potential powerful tool in mycological diagnosis and research. In this review, we summarize the applications of next-generation sequencing techniques in mycology.

Microlensed dual-fiber probe for depth-resolved fluorescence measurements

NASA Astrophysics Data System (ADS)

Choi, Hae Young; Ryu, Seon Young; Kim, Jae Young; Kim, Geon Hee; Park, Seong Jun; Lee, Byeong Ha; Chang, Ki Soo

2011-07-01

We propose and demonstrate a compact microlensed dual-fiber probe that has a good collection efficiency and a high depth-resolution ability for fluorescence measurements. The probe is formed with a conventional fusion splicer creating a common focusing lens on two fibers placed side by side. The collection efficiency of the fabricated probe was evaluated by measuring the fluorescence signal of a fresh ginkgo leaf. It was shown experimentally that the proposed probe could effectively collect the fluorescence signal with a six-fold increase compared to that of a general flat-tipped probe. The beam propagation method was used to design a probe with an optimized working distance and an improved resolving depth. It was found that the working distance depends mainly on the radius of curvature of the lens, whereas the resolving depth is determined by the core diameters of the illumination and collection fibers. The depth-resolved ability of probes with working distances of ~100 μm and 300 μm was validated by using a two-layer tissue phantom. The experimental results demonstrate that the microlensed dual-fiber probe has the potential to facilitate depth-resolved fluorescence detection of epithelial tissue.

QoS for Real Time Applications over Next Generation Data Networks

NASA Technical Reports Server (NTRS)

Ivancic, William; Atiquzzaman, Mohammed; Bai, Haowei; Su, Hongjun; Chitri, Jyotsna; Ahamed, Faruque

2001-01-01

Viewgraphs on Qualtity of Service (QOS) for real time applications over next generation data networks are presented. The progress to date include: Task 1: QoS in Integrated Services over DiffServ networks (UD); Task 2: Interconnecting ATN with the next generation Internet (UD); Task 3: QoS in DiffServ over ATM (UD); Task 4: Improving Explicit Congestion Notification with the Mark-Front Strategy (OSU); Task 5: Multiplexing VBR over VBR (OSU); and Task 6: Achieving QoS for TCP traffic in Satellite Networks with Differentiated Services (OSU).

The Next Generation Space Telescope

NASA Technical Reports Server (NTRS)

Bely, Pierre-Yves (Editor); Burrows,, Christopher J. (Editor); Illingworth,, Garth D.

1989-01-01

In Space Science in the Twenty-First Century, the Space Science Board of the National Research Council identified high-resolution-interferometry and high-throughput instruments as the imperative new initiatives for NASA in astronomy for the two decades spanning 1995 to 2015. In the optical range, the study recommended an 8 to 16-meter space telescope, destined to be the successor of the Hubble Space Telescope (HST), and to complement the ground-based 8 to 10-meter-class telescopes presently under construction. It might seem too early to start planning for a successor to HST. In fact, we are late. The lead time for such major missions is typically 25 years, and HST has been in the making even longer with its inception dating back to the early 1960s. The maturity of space technology and a more substantial technological base may lead to a shorter time scale for the development of the Next Generation Space Telescope (NGST). Optimistically, one could therefore anticipate that NGST be flown as early as 2010. On the other hand, the planned lifetime of HST is 15 years. So, even under the best circumstances, there will be a five year gap between the end of HST and the start of NGST. The purpose of this first workshop dedicated to NGST was to survey its scientific potential and technical challenges. The three-day meeting brought together 130 astronomers and engineers from government, industry and universities. Participants explored the technologies needed for building and operating the observatory, reviewed the current status and future prospects for astronomical instrumentation, and discussed the launch and space support capabilities likely to be available in the next decade. To focus discussion, the invited speakers were asked to base their presentations on two nominal concepts, a 10-meter telescope in space in high earth orbit, and a 16-meter telescope on the moon. The workshop closed with a panel discussion focused mainly on the scientific case, siting, and the

Next Generation Science Standards: Adoption and Implementation Workbook

ERIC Educational Resources Information Center

Peltzman, Alissa; Rodriguez, Nick

2013-01-01

The Next Generation Science Standards (NGSS) represent the culmination of years of collaboration and effort by states, science educators and experts from across the United States. Based on the National Research Council's "A Framework for K-12 Science Education" and developed in partnership with 26 lead states, the NGSS, when…

Framework for Leading Next Generation Science Standards Implementation

ERIC Educational Resources Information Center

Stiles, Katherine; Mundry, Susan; DiRanna, Kathy

2017-01-01

In response to the need to develop leaders to guide the implementation of the Next Generation Science Standards (NGSS), the Carnegie Corporation of New York provided funding to WestEd to develop a framework that defines the leadership knowledge and actions needed to effectively implement the NGSS. The development of the framework entailed…

Targeted enrichment strategies for next-generation plant biology

Treesearch

Richard Cronn; Brian J. Knaus; Aaron Liston; Peter J. Maughan; Matthew Parks; John V. Syring; Joshua Udall

2012-01-01

The dramatic advances offered by modem DNA sequencers continue to redefine the limits of what can be accomplished in comparative plant biology. Even with recent achievements, however, plant genomes present obstacles that can make it difficult to execute large-scale population and phylogenetic studies on next-generation sequencing platforms. Factors like large genome...

Mobility management techniques for the next-generation wireless networks

NASA Astrophysics Data System (ADS)

Sun, Junzhao; Howie, Douglas P.; Sauvola, Jaakko J.

2001-10-01

The tremendous demands from social market are pushing the booming development of mobile communications faster than ever before, leading to plenty of new advanced techniques emerging. With the converging of mobile and wireless communications with Internet services, the boundary between mobile personal telecommunications and wireless computer networks is disappearing. Wireless networks of the next generation need the support of all the advances on new architectures, standards, and protocols. Mobility management is an important issue in the area of mobile communications, which can be best solved at the network layer. One of the key features of the next generation wireless networks is all-IP infrastructure. This paper discusses the mobility management schemes for the next generation mobile networks through extending IP's functions with mobility support. A global hierarchical framework model for the mobility management of wireless networks is presented, in which the mobility management is divided into two complementary tasks: macro mobility and micro mobility. As the macro mobility solution, a basic principle of Mobile IP is introduced, together with the optimal schemes and the advances in IPv6. The disadvantages of the Mobile IP on solving the micro mobility problem are analyzed, on the basis of which three main proposals are discussed as the micro mobility solutions for mobile communications, including Hierarchical Mobile IP (HMIP), Cellular IP, and Handoff-Aware Wireless Access Internet Infrastructure (HAWAII). A unified model is also described in which the different micro mobility solutions can coexist simultaneously in mobile networks.

Designing Next Generation Massively Multithreaded Architectures for Irregular Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tumeo, Antonino; Secchi, Simone; Villa, Oreste

Irregular applications, such as data mining or graph-based computations, show unpredictable memory/network access patterns and control structures. Massively multi-threaded architectures with large node count, like the Cray XMT, have been shown to address their requirements better than commodity clusters. In this paper we present the approaches that we are currently pursuing to design future generations of these architectures. First, we introduce the Cray XMT and compare it to other multithreaded architectures. We then propose an evolution of the architecture, integrating multiple cores per node and next generation network interconnect. We advocate the use of hardware support for remote memory referencemore » aggregation to optimize network utilization. For this evaluation we developed a highly parallel, custom simulation infrastructure for multi-threaded systems. Our simulator executes unmodified XMT binaries with very large datasets, capturing effects due to contention and hot-spotting, while predicting execution times with greater than 90% accuracy. We also discuss the FPGA prototyping approach that we are employing to study efficient support for irregular applications in next generation manycore processors.« less

Next Generation Summer School

NASA Astrophysics Data System (ADS)

Eugenia, Marcu

2013-04-01

On 21.06.2010 the "Next Generation" Summer School has opened the doors for its first students. They were introduced in the astronomy world by astronomical observations, astronomy and radio-astronomy lectures, laboratory projects meant to initiate them into modern radio astronomy and radio communications. The didactic programme was structure as fallowing: 1) Astronomical elements from the visible spectrum (lectures + practical projects) 2) Radio astronomy elements (lectures + practical projects) 3) Radio communication base (didactic- recreative games) The students and professors accommodation was at the Agroturistic Pension "Popasul Iancului" situated at 800m from the Marisel Observatory. First day (summer solstice day) began with a practical activity: determination of the meridian by measurements of the shadow (the direction of one vertical alignment, when it has the smallest length). The experiment is very instructive and interesting because combines notions of physics, spatial geometry and basic astronomy elements. Next day the activities took place in four stages: the students processed the experimental data obtained on first day (on sheets of millimetre paper they represented the length of the shadow alignments according the time), each team realised its own sun quadrant, point were given considering the design and functionality of these quadrant, the four teams had to mimic important constellations on carton boards with phosphorescent sticky stars and the students, accompanied by the professors took a hiking trip to the surroundings, marking the interest point coordinates, using a GPS to establish the geographical coronations and at the end of the day the students realised a small map of central Marisel area based on the GPS data. On the third day, the students were introduced to basic notions of radio astronomy, the principal categories of artificial Earth satellites: low orbit satellites (LEO), Medium orbit satellites (MEO) and geostationary satellites (GEO

Next Generation Air Monitoring (NGAM) VOC Sensor Evaluation Report

EPA Science Inventory

This report summarizes the results of next generation air monitor (NGAM) volatile organic compound (VOC) evaluations performed using both laboratory as well as field scale settings. These evaluations focused on challenging lower cost (<$2500) NGAM technologies to either controlle...

Standardized Sky Partitioning for the Next Generation Astronomy and Space Science Archives

NASA Technical Reports Server (NTRS)

Lal, Nand (Technical Monitor); McLean, Brian

2004-01-01

The Johns Hopkins University and Space Telescope Science Institute are working together on this project to develop a library of standard software for data archives that will benefit the wider astronomical community. The ultimate goal was to develop and distribute a software library aimed at providing a common system for partitioning and indexing the sky in manageable sized regions and provide complex queries on the objects stored in this system. Whilst ongoing maintenance work will continue the primary goal has been completed. Most of the next generation sky surveys in the different wavelengths like 2MASS, GALEX, SDSS, GSC-II, DPOSS and FIRST have agreed on this common set of utilities. In this final report, we summarize work on the work elements assigned to the STScI project team.

The Next Generation of the Montage Image Mopsaic Engine

NASA Astrophysics Data System (ADS)

Berriman, G. Bruce; Good, John; Rusholme, Ben; Robitaille, Thomas

2016-01-01

We have released a major upgrade of the Montage image mosaic engine (http://montage.ipac.caltech.edu) , as part of a program to develop the next generation of the engine in response to the rapid changes in the data processing landscape in Astronomy, which is generating ever larger data sets in ever more complex formats . The new release (version 4) contains modules dedicated to creating and managing mosaics of data stored as multi-dimensional arrays ("data cubes"). The new release inherits the architectural benefits of portability and scalability of the original design. The code is publicly available on Git Hub and the Montage web page. The release includes a command line tool that supports visualization of large images, and the beta-release of a Python interface to the visualization tool. We will provide examples on how to use these these features. We are generating a mosaic of the Galactic Arecibo L-band Feed Array HI (GALFA-HI) Survey maps of neutral hydrogen in and around our Milky Way Galaxy, to assess the performance at scale and to develop tools and methodologies that will enable scientists inexpert in cloud processing to exploit could platforms for data processing and product generation at scale. Future releases include support for an R-tree based mechanism for fast discovery of and access to large data sets and on-demand access to calibrated SDSS DR9 data that exploits it; support for the Hierarchical Equal Area isoLatitude Pixelization (HEALPix) scheme, now standard for projects investigating cosmic background radiation (Gorski et al 2005); support fort the Tessellated Octahedral Adaptive Subdivision Transform (TOAST), the sky partitioning sky used by the WorldWide Telescope (WWT); and a public applications programming interface (API) in C that can be called from other languages, especially Python.

Multidisciplinary Analysis and Optimization Generation 1 and Next Steps

NASA Technical Reports Server (NTRS)

Naiman, Cynthia Gutierrez

2008-01-01

The Multidisciplinary Analysis & Optimization Working Group (MDAO WG) of the Systems Analysis Design & Optimization (SAD&O) discipline in the Fundamental Aeronautics Program s Subsonic Fixed Wing (SFW) project completed three major milestones during Fiscal Year (FY)08: "Requirements Definition" Milestone (1/31/08); "GEN 1 Integrated Multi-disciplinary Toolset" (Annual Performance Goal) (6/30/08); and "Define Architecture & Interfaces for Next Generation Open Source MDAO Framework" Milestone (9/30/08). Details of all three milestones are explained including documentation available, potential partner collaborations, and next steps in FY09.

Faint-Source-Star Planetary Microlensing: The Discovery of the Cold Gas-Giant Planet OGLE-2014-BLG-0676Lb

NASA Technical Reports Server (NTRS)

Rattenbury, N. J.; Bennett, D. P.; Sumi, T.; Koshimoto, N.; Bond, I. A.; Udalski, A.; Shvartzvald, Y.; Maoz, D.; Jorgensen, U. G.; Barry, R.;

Efficient Cryptography for the Next Generation Secure Cloud

ERIC Educational Resources Information Center

Kupcu, Alptekin

2010-01-01

Peer-to-peer (P2P) systems, and client-server type storage and computation outsourcing constitute some of the major applications that the next generation cloud schemes will address. Since these applications are just emerging, it is the perfect time to design them with security and privacy in mind. Furthermore, considering the high-churn…

Microlensing of Relativistic Knots in the Quasar HE 1104-1805 AB

NASA Astrophysics Data System (ADS)

Schechter, Paul L.; Udalski, A.; Szymański, M.; Kubiak, M.; Pietrzyński, G.; Soszyński, I.; Woźniak, P.; Żebruń, K.; Szewczyk, O.; Wyrzykowski, Ł.

2003-02-01

We present 3 years of photometry of the ``Double Hamburger'' lensed quasar, HE 1104-1805 AB, obtained on 102 separate nights using the Optical Gravitational Lensing Experiment 1.3 m telescope. Both the A and B images show variations, but with substantial differences in the light curves at all time delays. At the 310 day delay reported by Wisotzki and collaborators, the difference light curve has an rms amplitude of 0.060 mag. The structure functions for the A and B images are quite different, with image A more than twice as variable as image B (a factor of 4 in structure function) on timescales of less than a month. Adopting microlensing as a working hypothesis for the uncorrelated variability, the short timescale argues for the relativistic motion of one or more components of the source. We argue that the small amplitude of the fluctuations is due to the finite size of the source with respect to the microlenses.

Next-Generation of Allergen-Specific Immunotherapies: Molecular Approaches.

PubMed

Curin, Mirela; Khaitov, Musa; Karaulov, Alexander; Namazova-Baranova, Leyla; Campana, Raffaela; Garib, Victoria; Valenta, Rudolf

2018-06-09

The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy. AIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the therapeutic antigen preparations which are derived from natural allergen sources. The field of allergy diagnosis is currently undergoing a dramatic improvement through the use of molecular testing with defined, mainly recombinant allergens which allows high-resolution diagnosis. Several studies demonstrate that molecular testing in early childhood can predict the development of symptomatic allergy later on in life. Clinical studies indicate that molecular AIT approaches have the potential to improve therapy of allergic diseases and may be used as allergen-specific forms of secondary and eventually primary prevention for allergy.

Hybrid Network Architectures for the Next Generation NAS

NASA Technical Reports Server (NTRS)

Madubata, Christian

2003-01-01

To meet the needs of the 21st Century NAS, an integrated, network-centric infrastructure is essential that is characterized by secure, high bandwidth, digital communication systems that support precision navigation capable of reducing position errors for all aircraft to within a few meters. This system will also require precision surveillance systems capable of accurately locating all aircraft, and automatically detecting any deviations from an approved path within seconds and be able to deliver high resolution weather forecasts - critical to create 4- dimensional (space and time) profiles for up to 6 hours for all atmospheric conditions affecting aviation, including wake vortices. The 21st Century NAS will be characterized by highly accurate digital data bases depicting terrain, obstacle, and airport information no matter what visibility conditions exist. This research task will be to perform a high-level requirements analysis of the applications, information and services required by the next generation National Airspace System. The investigation and analysis is expected to lead to the development and design of several national network-centric communications architectures that would be capable of supporting the Next Generation NAS.

On the way to the creation of next generation photoactive materials.

PubMed

Emeline, A V; Kuznetsov, V N; Ryabchuk, V K; Serpone, N

2012-11-01

Transition from first- to second-generation photocatalysts has followed the notion that greater absorption of light in the visible region would yield greater spectral sensitivity and greater photoactivity. Though a promising strategy, in practice, it did not meet expectation because of various side issues, which in many cases has led to loss of photoactivity and chemical reactivity. This article examines some earlier notions that arose from applications of different metal oxides (e.g., TiO(2), ZnO, MgO among others) that made these oxides good photocatalysts in many processes. Phenomena that proved relevant in developing next generation photoactive materials are considered: the dependence of the activity of photocatalysts on the band gap energy, the spectral variations of the activity of photoactive materials, and the spectral variations of selectivity of photoactive materials. The tendency to decrease the energy of actinic photons through doping in forming second-generation photocatalysts is completely opposite the fundamental observation in first-generation photocatalysts whereby the activity increased with increasing band gap energy. Extension of spectral sensitivity of second-generation photoactive materials also caused a decrease of their photoactivity; hence, some notions are reconsidered to produce next(third) generation photoactive materials. The article proposes the following concepts to develop next generation photocatalysts: (1) multi(two)-photon excitation of photoactive materials with lower energy photons to achieve the same excited state as with higher energy photons, (2) utilization of heterojunctions to drive electronic processes in the desired direction, and (3) selective photoexcitation of localized electronic states to gain better selectivity.

Next Generation Loading System for Detonators and Primers

DTIC Science & Technology

Designed , fabricated and installed next generation tooling to provide additional manufacturing capabilities for new detonators and other small...prototype munitions on automated, semi-automated and manual machines. Lead design effort, procured and installed a primary explosive Drying Oven for a pilot...facility. Designed , fabricated and installed a Primary Explosives Waste Treatment System in a pilot environmental processing facility. Designed

TWO STARS TWO WAYS: CONFIRMING A MICROLENSING BINARY LENS SOLUTION WITH A SPECTROSCOPIC MEASUREMENT OF THE ORBIT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yee, Jennifer C.; Johnson, John Asher; Eastman, Jason

Light curves of microlensing events involving stellar binaries and planetary systems can provide information about the orbital elements of the system due to orbital modulations of the caustic structure. Accurately measuring the orbit in either the stellar or planetary case requires detailed modeling of subtle deviations in the light curve. At the same time, the natural, Cartesian parameterization of a microlensing binary is partially degenerate with the microlens parallax. Hence, it is desirable to perform independent tests of the predictions of microlens orbit models using radial velocity (RV) time series of the lens binary system. To this end, we presentmore » 3.5 years of RV monitoring of the binary lens system OGLE-2009-BLG-020 L, for which Skowron et al. constrained all internal parameters of the 200–700 day orbit. Our RV measurements reveal an orbit that is consistent with the predictions of the microlens light curve analysis, thereby providing the first confirmation of orbital elements inferred from microlensing events.« less

The Case for Home-Grown, Sustainable, Next Generation Library Services

ERIC Educational Resources Information Center

Haefele, Chad

2011-01-01

While libraries offer next generation public services such as mobile access and e-books, these services are often neither home-grown nor sustainable. Libraries have a history of lending and services built on a simple model: they purchase an item and then provide it to the community. Unfortunately, the latest generation of services offered by…

U.S. Department of Energy awards $200 million for next-generation

Science.gov Websites

build a powerful new next-gen supercomputer, Aurora. The press conference took place at Chicago tech Congress and industry at the announcement of DOE's award of $200 million to Argonne in order to build a accelerate to next-generation exascale computing. DOE earlier announced a $325 million investment to build

Environmental Information for the U.S. Next Generation Air Transportation System (NextGen)

NASA Astrophysics Data System (ADS)

Murray, J.; Miner, C.; Pace, D.; Minnis, P.; Mecikalski, J.; Feltz, W.; Johnson, D.; Iskendarian, H.; Haynes, J.

2009-09-01

It is estimated that weather is responsible for approximately 70% of all air traffic delays and cancellations in the United States. Annually, this produces an overall economic loss of nearly 40B. The FAA and NASA have determined that weather impacts and other environmental constraints on the U.S. National Airspace System (NAS) will increase to the point of system unsustainability unless the NAS is radically transformed. A Next Generation Air Transportation System (NextGen) is planned to accommodate the anticipated demand for increased system capacity and the super-density operations that this transformation will entail. The heart of the environmental information component that is being developed for NextGen will be a 4-dimensional data cube which will include a single authoritative source comprising probabilistic weather information for NextGen Air Traffic Management (ATM) systems. Aviation weather constraints and safety hazards typically comprise meso-scale, storm-scale and microscale observables that can significantly impact both terminal and enroute aviation operations. With these operational impacts in mind, functional and performance requirements for the NextGen weather system were established which require significant improvements in observation and forecasting capabilities. This will include satellite observations from geostationary and/or polar-orbiting hyperspectral sounders, multi-spectral imagers, lightning mappers, space weather monitors and other environmental observing systems. It will also require improved in situ and remotely sensed observations from ground-based and airborne systems. These observations will be used to better understand and to develop forecasting applications for convective weather, in-flight icing, turbulence, ceilings and visibility, volcanic ash, space weather and the environmental impacts of aviation. Cutting-edge collaborative research efforts and results from NASA, NOAA and the FAA which address these phenomena are summarized

OGLE-III Microlensing Events and the Structure of the Galactic Bulge

NASA Astrophysics Data System (ADS)

Wyrzykowski, Łukasz; Rynkiewicz, Alicja E.; Skowron, Jan; Kozłowski, Szymon; Udalski, Andrzej; Szymański, Michał K.; Kubiak, Marcin; Soszyński, Igor; Pietrzyński, Grzegorz; Poleski, Radosław; Pietrukowicz, Paweł; Pawlak, Michał

2015-01-01

We present and study the largest and most comprehensive catalog of microlensing events ever constructed. The sample of standard microlensing events comprises 3718 unique events from 2001-2009 with 1409 events that had not been detected before in real-time by the Early Warning System of the Optical Gravitational Lensing Experiment. The search pipeline uses machine learning algorithms to help find rare phenomena among 150 million objects and to derive the detection efficiency. Applications of the catalog can be numerous, from analyzing individual events to large statistical studies of the Galactic mass, kinematics distributions, and planetary abundances. We derive maps of the mean Einstein ring crossing time of events spanning 31 deg2 toward the Galactic center and compare the observed distributions with the most recent models. We find good agreement within the observed region and we see the signature of the tilt of the bar in the microlensing data. However, the asymmetry of the mean timescales seems to rise more steeply than predicted, indicating either a somewhat different orientation of the bar or a larger bar width. The map of events with sources in the Galactic bulge shows a dependence of the mean timescale on the Galactic latitude, signaling an increasing contribution from disk lenses closer to the plane relative to the height of the disk. Our data present a perfect set for comparing and enhancing new models of the central parts of the Milky Way and creating a three-dimensional picture of the Galaxy. Based on observations obtained with the 1.3 m Warsaw telescope at the Las Campanas Observatory of the Carnegie Institution for Science.

The Next Generation Virgo Cluster Survey. IV. NGC 4216: A Bombarded Spiral in the Virgo Cluster

NASA Astrophysics Data System (ADS)

Paudel, Sanjaya; Duc, Pierre-Alain; Côté, Patrick; Cuillandre, Jean-Charles; Ferrarese, Laura; Ferriere, Etienne; Gwyn, Stephen D. J.; Mihos, J. Christopher; Vollmer, Bernd; Balogh, Michael L.; Carlberg, Ray G.; Boissier, Samuel; Boselli, Alessandro; Durrell, Patrick R.; Emsellem, Eric; MacArthur, Lauren A.; Mei, Simona; Michel-Dansac, Leo; van Driel, Wim

2013-04-01

The final stages of mass assembly of present-day massive galaxies are expected to occur through the accretion of multiple satellites. Cosmological simulations thus predict a high frequency of stellar streams resulting from this mass accretion around the massive galaxies in the Local Volume. Such tidal streams are difficult to observe, especially in dense cluster environments, where they are readily destroyed. We present an investigation into the origins of a series of interlaced narrow filamentary stellar structures, loops and plumes in the vicinity of the Virgo Cluster, edge-on spiral galaxy, NGC 4216 that were previously identified by the Blackbird telescope. Using the deeper, higher-resolution, and precisely calibrated optical CFHT/MegaCam images obtained as part of the Next Generation Virgo Cluster Survey (NGVS), we confirm the previously identified features and identify a few additional structures. The NGVS data allowed us to make a physical study of these low surface brightness features and investigate their origin. The likely progenitors of the structures were identified as either already cataloged Virgo Cluster Catalog dwarfs or newly discovered satellites caught in the act of being destroyed. They have the same g - i color index and likely contain similar stellar populations. The alignment of three dwarfs along an apparently single stream is intriguing, and we cannot totally exclude that these are second-generation dwarf galaxies being born inside the filament from the debris of an original dwarf. The observed complex structures, including in particular a stream apparently emanating from a satellite of a satellite, point to a high rate of ongoing dwarf destruction/accretion in the region of the Virgo Cluster where NGC 4216 is located. We discuss the age of the interactions and whether they occurred in a group that is just falling into the cluster and shows signs of the so-called pre-processing before it gets affected by the cluster environment, or in a

Next-generation digital information storage in DNA.

PubMed

Church, George M; Gao, Yuan; Kosuri, Sriram

2012-09-28

Digital information is accumulating at an astounding rate, straining our ability to store and archive it. DNA is among the most dense and stable information media known. The development of new technologies in both DNA synthesis and sequencing make DNA an increasingly feasible digital storage medium. We developed a strategy to encode arbitrary digital information in DNA, wrote a 5.27-megabit book using DNA microchips, and read the book by using next-generation DNA sequencing.

Next-Generation Sequencing of Antibody Display Repertoires

PubMed Central

Rouet, Romain; Jackson, Katherine J. L.; Langley, David B.; Christ, Daniel

2018-01-01

In vitro selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high affinity binders can be selected from diverse repertoires. Here, we review strategies for the next-generation sequencing (NGS) of phage- and other antibody-display libraries, as well as NGS platforms and analysis tools. Moreover, we discuss recent examples relating to the use of NGS to assess library diversity, clonal enrichment, and affinity maturation. PMID:29472918

Popular Imagination and Identity Politics: Reading the Future in "Star Trek: The Next Generation."

ERIC Educational Resources Information Center

Ott, Brian L.; Aoki, Eric

2001-01-01

Analyzes the television series "Star Trek: The Next Generation." Theorizes the relationship between collective visions of the future and the identity politics of the present. Argues that "The Next Generation" invites audiences to participate in a shared sense of the future that constrains human agency and (re)produces the…

Advancing Next-Generation Energy in Indian Country (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This fact provides information on the Strategic Technical Assistance Response Team (START) Program, a U.S. Department of Energy Office of Indian Energy Policy and Programs (DOE-IE) initiative to provide technical expertise to support the development of next-generation energy projects in Indian Country.

Development of the Next Generation Air Quality Modeling System

EPA Science Inventory

A next generation air quality modeling system is being developed at the U.S. EPA to enable modeling of air quality from global to regional to (eventually) local scales. We envision that the system will have three configurations: 1. Global meteorology with seamless mesh refinemen...

Quality of Service for Real-Time Applications Over Next Generation Data Networks

NASA Technical Reports Server (NTRS)

Ivancic, William; Atiquzzaman, Mohammed; Bai, Haowei; Su, Hongjun; Jain, Raj; Duresi, Arjan; Goyal, Mukyl; Bharani, Venkata; Liu, Chunlei; Kota, Sastri

2001-01-01

This project, which started on January 1, 2000, was funded by NASA Glenn Research Center for duration of one year. The deliverables of the project included the following tasks: Study of QoS mapping between the edge and core networks envisioned in the Next Generation networks will provide us with the QoS guarantees that can be obtained from next generation networks. Buffer management techniques to provide strict guarantees to real-time end-to-end applications through preferential treatment to packets belonging to real-time applications. In particular, use of ECN to help reduce the loss on high bandwidth-delay product satellite networks needs to be studied. Effect of Prioritized Packet Discard to increase goodput of the network and reduce the buffering requirements in the ATM switches. Provision of new IP circuit emulation services over Satellite IP backbones using MPLS will be studied. Determine the architecture and requirements for internetworking ATN and the Next Generation Internet for real-time applications.

Global Adjoint Tomography: Next-Generation Models

NASA Astrophysics Data System (ADS)

Bozdag, Ebru; Lefebvre, Matthieu; Lei, Wenjie; Orsvuran, Ridvan; Peter, Daniel; Ruan, Youyi; Smith, James; Komatitsch, Dimitri; Tromp, Jeroen

2017-04-01

The first-generation global adjoint tomography model GLAD-M15 (Bozdag et al. 2016) is the result of 15 conjugate-gradient iterations based on GPU-accelerated spectral-element simulations of 3D wave propagation and Fréchet kernels. For simplicity, GLAD-M15 was constructed as an elastic model with transverse isotropy confined to the upper mantle. However, Earth's mantle and crust show significant evidence of anisotropy as a result of its composition and deformation. There may be different sources of seismic anisotropy affecting both body and surface waves. As a first attempt, we initially tackle with surface-wave anisotropy and proceed iterations using the same 253 earthquake data set used in GLAD-M15 with an emphasize on upper-mantle. Furthermore, we explore new misfits, such as double-difference measurements (Yuan et al. 2016), to better deal with the possible artifacts of the uneven distribution of seismic stations globally and minimize source uncertainties in structural inversions. We will present our observations with the initial results of azimuthally anisotropic inversions and also discuss the next generation global models with various parametrizations. Meanwhile our goal is to use all available seismic data in imaging. This however requires a solid framework to perform iterative adjoint tomography workflows with big data on supercomputers. We will talk about developments in adjoint tomography workflow from the need of defining new seismic and computational data formats (e.g., ASDF by Krischer et al. 2016, ADIOS by Liu et al. 2011) to developing new pre- and post-processing tools together with experimenting workflow management tools, such as Pegasus (Deelman et al. 2015). All our simulations are performed on Oak Ridge National Laboratory's Cray XK7 "Titan" system. Our ultimate aim is to get ready to harness ORNL's next-generation supercomputer "Summit", an IBM with Power-9 CPUs and NVIDIA Volta GPU accelerators, to be ready by 2018 which will enable us to

Next Generation Clustered Heat Maps | Informatics Technology for Cancer Research (ITCR)

Cancer.gov

Next-Generation (Clustered) Heat Maps are interactive heat maps that enable the user to zoom and pan across the heatmap, alter its color scheme, generate production quality PDFs, and link out from rows, columns, and individual heatmap entries to related statistics, databases and other information.

Next-generation Sequencing-based genomic profiling: Fostering innovation in cancer care?

PubMed

Fernandes, Gustavo S; Marques, Daniel F; Girardi, Daniel M; Braghiroli, Maria Ignez F; Coudry, Renata A; Meireles, Sibele I; Katz, Artur; Hoff, Paulo M

2017-10-01

With the development of next-generation sequencing (NGS) technologies, DNA sequencing has been increasingly utilized in clinical practice. Our goal was to investigate the impact of genomic evaluation on treatment decisions for heavily pretreated patients with metastatic cancer. We analyzed metastatic cancer patients from a single institution whose cancers had progressed after all available standard-of-care therapies and whose tumors underwent next-generation sequencing analysis. We determined the percentage of patients who received any therapy directed by the test, and its efficacy. From July 2013 to December 2015, 185 consecutive patients were tested using a commercially available next-generation sequencing-based test, and 157 patients were eligible. Sixty-six patients (42.0%) were female, and 91 (58.0%) were male. The mean age at diagnosis was 52.2 years, and the mean number of pre-test lines of systemic treatment was 2.7. One hundred and seventy-seven patients (95.6%) had at least one identified gene alteration. Twenty-four patients (15.2%) underwent systemic treatment directed by the test result. Of these, one patient had a complete response, four (16.7%) had partial responses, two (8.3%) had stable disease, and 17 (70.8%) had disease progression as the best result. The median progression-free survival time with matched therapy was 1.6 months, and the median overall survival was 10 months. We identified a high prevalence of gene alterations using an next-generation sequencing test. Although some benefit was associated with the matched therapy, most of the patients had disease progression as the best response, indicating the limited biological potential and unclear clinical relevance of this practice.

Faint-source-star planetary microlensing: the discovery of the cold gas-giant planet OGLE-2014-BLG-0676Lb

NASA Astrophysics Data System (ADS)

Rattenbury, N. J.; Bennett, D. P.; Sumi, T.; Koshimoto, N.; Bond, I. A.; Udalski, A.; Shvartzvald, Y.; Maoz, D.; Jørgensen, U. G.; Dominik, M.; Street, R. A.; Tsapras, Y.; Abe, F.; Asakura, Y.; Barry, R.; Bhattacharya, A.; Donachie, M.; Evans, P.; Freeman, M.; Fukui, A.; Hirao, Y.; Itow, Y.; Li, M. C. A.; Ling, C. H.; Masuda, K.; Matsubara, Y.; Muraki, Y.; Nagakane, M.; Ohnishi, K.; Oyokawa, H.; Saito, To.; Sharan, A.; Sullivan, D. J.; Suzuki, D.; Tristram, P. J.; Yonehara, A.; Poleski, R.; Skowron, J.; Mróz, P.; Szymański, M. K.; Soszyński, I.; Pietrukowicz, P.; Kozłowski, S.; Ulaczyk, K.; Wyrzykowski, Ł.; Friedmann, M.; Kaspi, S.; Alsubai, K.; Browne, P.; Andersen, J. M.; Bozza, V.; Calchi Novati, S.; Damerdji, Y.; Diehl, C.; Dreizler, S.; Elyiv, A.; Giannini, E.; Hardis, S.; Harpsøe, K.; Hinse, T. C.; Liebig, C.; Hundertmark, M.; Juncher, D.; Kains, N.; Kerins, E.; Korhonen, H.; Mancini, L.; Martin, R.; Mathiasen, M.; Rabus, M.; Rahvar, S.; Scarpetta, G.; Skottfelt, J.; Snodgrass, C.; Surdej, J.; Taylor, J.; Tregloan-Reed, J.; Vilela, C.; Wambsganss, J.; Williams, A.; D'Ago, G.; Bachelet, E.; Bramich, D. M.; Figuera Jaimes, R.; Horne, K.; Menzies, J.; Schmidt, R.; Steele, I. A.

2017-04-01

We report the discovery of a planet - OGLE-2014-BLG-0676Lb- via gravitational microlensing. Observations for the lensing event were made by the following groups: Microlensing Observations in Astrophysics; Optical Gravitational Lensing Experiment; Wise Observatory; RoboNET/Las Cumbres Observatory Global Telescope; Microlensing Network for the Detection of Small Terrestrial Exoplanets; and μ-FUN. All analyses of the light-curve data favour a lens system comprising a planetary mass orbiting a host star. The most-favoured binary lens model has a mass ratio between the two lens masses of (4.78 ± 0.13) × 10-3. Subject to some important assumptions, a Bayesian probability density analysis suggests the lens system comprises a 3.09_{-1.12}^{+1.02} MJ planet orbiting a 0.62_{-0.22}^{+0.20} M⊙ host star at a deprojected orbital separation of 4.40_{-1.46}^{+2.16} au. The distance to the lens system is 2.22_{-0.83}^{+0.96} kpc. Planet OGLE-2014-BLG-0676Lb provides additional data to the growing number of cool planets discovered using gravitational microlensing against which planetary formation theories may be tested. Most of the light in the baseline of this event is expected to come from the lens and thus high-resolution imaging observations could confirm our planetary model interpretation.

Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines.

PubMed

Petrie, Joshua G; Gordon, Aubree

2018-03-26

The National Institute of Allergy and Infectious Diseases recently published a strategic plan for the development of a universal influenza vaccine. This plan focuses on improving understanding of influenza infection, the development of influenza immunity, and rational design of new vaccines. Epidemiological studies such as prospective, longitudinal cohort studies are essential to the completion of these objectives. In this review, we discuss the contributions of epidemiological studies to our current knowledge of vaccines and correlates of immunity, and how they can contribute to the development and evaluation of the next generation of influenza vaccines. These studies have been critical in monitoring the effectiveness of current influenza vaccines, identifying issues such as low vaccine effectiveness, reduced effectiveness among those who receive repeated vaccination, and issues related to egg adaptation during the manufacturing process. Epidemiological studies have also identified population-level correlates of protection that can inform the design and development of next generation influenza vaccines. Going forward, there is an enduring need for epidemiological studies to continue advancing knowledge of correlates of protection and the development of immunity, to evaluate and monitor the effectiveness of next generation influenza vaccines, and to inform recommendations for their use.

Recent progress in nanostructured next-generation field emission devices

NASA Astrophysics Data System (ADS)

Mittal, Gaurav; Lahiri, Indranil

2014-08-01

Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40-50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices.

Next Generation Advanced Video Guidance Sensor Development and Test

NASA Technical Reports Server (NTRS)

Howard, Richard T.; Bryan, Thomas C.; Lee, Jimmy; Robertson, Bryan

2009-01-01

The Advanced Video Guidance Sensor (AVGS) was the primary docking sensor for the Orbital Express mission. The sensor performed extremely well during the mission, and the technology has been proven on orbit in other flights too. Parts obsolescence issues prevented the construction of more AVGS units, so the next generation of sensor was designed with current parts and updated to support future programs. The Next Generation Advanced Video Guidance Sensor (NGAVGS) has been tested as a breadboard, two different brassboard units, and a prototype. The testing revealed further improvements that could be made and demonstrated capability beyond that ever demonstrated by the sensor on orbit. This paper presents some of the sensor history, parts obsolescence issues, radiation concerns, and software improvements to the NGAVGS. In addition, some of the testing and test results are presented. The NGAVGS has shown that it will meet the general requirements for any space proximity operations or docking need.

OPAC: The Next Generation Placing an Encore Front End onto a SirsiDynix ILS

ERIC Educational Resources Information Center

Marcin, Susan; Morris, Peter

2008-01-01

Over the last few years, there has been a wealth of materials written and presented on next-generation library catalogs. These next-generation interfaces strive to turn "standard" integrated library systems (ILSs) into more nimble and robust search platforms that offer more user-friendly 2.0 enhancements for users. Rather than abandoning…

Development of 3D out-of-plane SU-8 microlenses using modified micromolding in capillaries (MIMIC) technology

NASA Astrophysics Data System (ADS)

Llobera, A.; Wilke, R.; Johnson, D. W.; Büttgenbach, S.

2006-04-01

This paper describes a modification of the standard MIMIC technology, solving its main drawbacks, to define arrays of spherical or ellipsoidal microlenses. Perfectly symmetrical meniscuses have been obtained by using a XP SU-8 NO-2 layer beneath the PDMS mold. Moreover, the photostructurable properties of this polymer allow obtaining self-alignment structures for adequate fiber optics positioning. Microchannels ended with these meniscuses have been filled with standard SU-8 to obtain 3D microlenses. Agreement between theory and experimental results allows confirming the validity of the proposed technology.

Genetic diagnosis of familial hypercholesterolaemia by targeted next-generation sequencing

PubMed Central

Maglio, C; Mancina, R M; Motta, B M; Stef, M; Pirazzi, C; Palacios, L; Askaryar, N; Borén, J; Wiklund, O; Romeo, S

2014-01-01

Maglio C., Mancina R. M., Motta B. M., Stef M., Pirazzi C., Palacios L., Askaryar N., Borén J., Wiklund O., Romeo S. (University of Gothenburg, Gothenburg, Sweden; University Magna Graecia of Catanzaro, Italy; University of Milan, Italy; Progenika Biopharma SA, Derio, Spain). Genetic diagnosis of familial hypercholesterolaemia by targeted next-generation sequencing. Objectives The aim of this study was to combine clinical criteria and next-generation sequencing (pyrosequencing) to establish a diagnosis of familial hypercholesterolaemia (FH). Design, setting and subjects A total of 77 subjects with a Dutch Lipid Clinic Network score of ≥3 (possible, probable or definite FH clinical diagnosis) were recruited from the Lipid Clinic at Sahlgrenska Hospital, Gothenburg, Sweden. Next-generation sequencing was performed in all subjects using SEQPRO LIPO RS, a kit that detects mutations in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), proprotein convertase subtilisin/kexin type 9 (PCSK9) and LDLR adapter protein 1 (LDLRAP1) genes; copy-number variations in the LDLR gene were also examined. Results A total of 26 mutations were detected in 50 subjects (65% success rate). Amongst these, 23 mutations were in the LDLR gene, two in the APOB gene and one in the PCSK9 gene. Four mutations with unknown pathogenicity were detected in LDLR. Of these, three mutations (Gly505Asp, Ile585Thr and Gln660Arg) have been previously reported in subjects with FH, but their pathogenicity has not been proved. The fourth, a mutation in LDLR affecting a splicing site (exon 6–intron 6) has not previously been reported; it was found to segregate with high cholesterol levels in the family of the proband. Conclusions Using a combination of clinical criteria and targeted next-generation sequencing, we have achieved FH diagnosis with a high success rate. Furthermore, we identified a new splicing-site mutation in the LDLR gene. PMID:24785115

Next Generation Antibody Therapeutics Using Bispecific Antibody Technology.

PubMed

Igawa, Tomoyuki

2017-01-01

Nearly fifty monoclonal antibodies have been approved to date, and the market for monoclonal antibodies is expected to continue to grow. Since global competition in the field of antibody therapeutics is intense, we need to establish novel antibody engineering technologies to provide true benefit for patients, with differentiated product values. Bispecific antibodies are among the next generation of antibody therapeutics that can bind to two different target antigens by the two arms of immunoglobulin G (IgG) molecule, and are thus believed to be applicable to various therapeutic needs. Until recently, large scale manufacturing of human IgG bispecific antibody was impossible. We have established a technology, named asymmetric re-engineering technology (ART)-Ig, to enable large scale manufacturing of bispecific antibodies. Three examples of next generation antibody therapeutics using ART-Ig technology are described. Recent updates on bispecific antibodies against factor IXa and factor X for the treatment of hemophilia A, bispecific antibodies against a tumor specific antigen and T cell surface marker CD3 for cancer immunotherapy, and bispecific antibodies against two different epitopes of soluble antigen with pH-dependent binding property for the elimination of soluble antigen from plasma are also described.

Advanced Applications of Next-Generation Sequencing Technologies to Orchid Biology.

PubMed

Yeh, Chuan-Ming; Liu, Zhong-Jian; Tsai, Wen-Chieh

2018-01-01

Next-generation sequencing technologies are revolutionizing biology by permitting, transcriptome sequencing, whole-genome sequencing and resequencing, and genome-wide single nucleotide polymorphism profiling. Orchid research has benefited from this breakthrough, and a few orchid genomes are now available; new biological questions can be approached and new breeding strategies can be designed. The first part of this review describes the unique features of orchid biology. The second part provides an overview of the current next-generation sequencing platforms, many of which are already used in plant laboratories. The third part summarizes the state of orchid transcriptome and genome sequencing and illustrates current achievements. The genetic sequences currently obtained will not only provide a broad scope for the study of orchid biology, but also serves as a starting point for uncovering the mystery of orchid evolution.

A survey of tools and resources for the next generation analyst

NASA Astrophysics Data System (ADS)

Hall, David L.; Graham, Jake; Catherman, Emily

2015-05-01

We have previously argued that a combination of trends in information technology (IT) and changing habits of people using IT provide opportunities for the emergence of a new generation of analysts that can perform effective intelligence, surveillance and reconnaissance (ISR) on a "do it yourself" (DIY) or "armchair" approach (see D.L. Hall and J. Llinas (2014)). Key technology advances include: i) new sensing capabilities including the use of micro-scale sensors and ad hoc deployment platforms such as commercial drones, ii) advanced computing capabilities in mobile devices that allow advanced signal and image processing and modeling, iii) intelligent interconnections due to advances in "web N" capabilities, and iv) global interconnectivity and increasing bandwidth. In addition, the changing habits of the digital natives reflect new ways of collecting and reporting information, sharing information, and collaborating in dynamic teams. This paper provides a survey and assessment of tools and resources to support this emerging analysis approach. The tools range from large-scale commercial tools such as IBM i2 Analyst Notebook, Palantir, and GeoSuite to emerging open source tools such as GeoViz and DECIDE from university research centers. The tools include geospatial visualization tools, social network analysis tools and decision aids. A summary of tools is provided along with links to web sites for tool access.

Constraining Galaxy Evolution With Hubble's Next Generation Spectral Library

NASA Astrophysics Data System (ADS)

Heap, S.; Lindler, D. J.

2009-03-01

We present Hubble's Next Generation Spectral Library, a library of UV-optical spectra (0.2-1.0 μ) of 378 stars. We show that the mid-UV spectrum can be used to constrain the ages and metallicities of high-redshift galaxies presently being observed with large, ground-based telescopes.

The "Next Generation Science Standards" and the Life Sciences

ERIC Educational Resources Information Center

Bybee, Rodger W.

2013-01-01

Publication of the "Next Generation Science Standards" will be just short of two decades since publication of the "National Science Education Standards" (NRC 1996). In that time, biology and science education communities have advanced, and the new standards will reflect that progress (NRC 1999, 2007, 2009; Kress and Barrett…

Gaia16aye binary microlensing event is rising for the 5th time

NASA Astrophysics Data System (ADS)

Wyrzykowski, L.; Mroz, P.; Rybicki, K.; Altavilla, G.; Bakis, V.; Bendjoya, P.; Birenbaum, G.; Blagorodnova, N.; Blanco-Cuaresma, S.; Bonanos, A.; Bozza, V.; Britavskiy, N.; Burgaz, U.; Butterley, T.; Capuozzo, P.; Carrasco, J. M.; Chruslinska, M.; Damljanovic, G.; Dapergolas, T.; Dennefeld, M.; Dhillon, V. S.; Dominik, M.; Esenoglu, H.; Fossey, S.; Gomboc, A.; Hallokoun, N.; Hamanowicz, A.; Hardy, L. K.; Hudec, R.; Khamitov, I.; Klencki, J.; Kolaczkowski, Z.; Kolb, U.; Leonini, S.; Leto, G.; Lewis, F.; Liakos, A.; Littlefair, S. P.; Maoz, D.; Maund, J. R.; Mikolajczyk, P.; Palaversa, L.; Pawlak, M.; Penny, M.; Piascik, A.; Reig, P.; Rhodes, L.; Russell, D.; Sanchez, R. Z.; Shappee, B.; Shvartzvald, Y.; Sitek, M.; Sniegowska, M.; Sokolovsky, K.; Steele, I.; Street, R.; Tomasella, L.; Trascinelli, L.; Wiersema, K.; Wilson, R. W.; Zharkov, I.; Zola, S.; Zubareva, A.

2017-05-01

Gaia16aye, nicknamed Ayers Rock (19:40:01.13 +30:07:53.4, J2000) was detected in August 2016 and continue on-going, becoming the longest microlensing event found in the Galactic Disk (ATEL #9376, #9507).

TriG: Next Generation Scalable Spaceborne GNSS Receiver

NASA Technical Reports Server (NTRS)

Tien, Jeffrey Y.; Okihiro, Brian Bachman; Esterhuizen, Stephan X.; Franklin, Garth W.; Meehan, Thomas K.; Munson, Timothy N.; Robison, David E.; Turbiner, Dmitry; Young, Lawrence E.

2012-01-01

TriG is the next generation NASA scalable space GNSS Science Receiver. It will track all GNSS and additional signals (i.e. GPS, GLONASS, Galileo, Compass and Doris). Scalable 3U architecture and fully software and firmware recofigurable, enabling optimization to meet specific mission requirements. TriG GNSS EM is currently undergoing testing and is expected to complete full performance testing later this year.

Towards Intelligent Control for Next Generation CESTOL Aircraft

NASA Technical Reports Server (NTRS)

Acosta, Diana Michelle

2008-01-01

This talk will present the motivation, research approach and status of intelligent control research for Next Generation Cruise Efficient Short Take Off and Landing (CESTOL) aircraft. An introduction to the challenges of CESTOL control will be given, leading into an assessment of potential control solutions. The approach of the control research will be discussed, including a brief overview of the technical aspects of the research.

ASAS-SN Confirmation of the Bright Microlensing Event TCP J05074264+2447555

NASA Astrophysics Data System (ADS)

Jayasinghe, T.; Dong, Subo; Stanek, K. Z.; Kochanek, C. S.; Thompson, T. A.; Prieto, J. L.; Shappee, B. J.; Holoien, T. W.-S.

2017-11-01

The transient TCP J05074264+2447555 was first discovered by T. Kojima on UT 2017-10-25.688. The ASAS-SN Sky Patrol light curve (Shappee et al. 2014; Kochanek et al. 2017) and follow-up spectroscopy (ATel #10919) suggested this to be a probable microlensing event.

DARK MATTER MASS FRACTION IN LENS GALAXIES: NEW ESTIMATES FROM MICROLENSING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiménez-Vicente, J.; Mediavilla, E.; Kochanek, C. S.

2015-02-01

We present a joint estimate of the stellar/dark matter mass fraction in lens galaxies and the average size of the accretion disk of lensed quasars based on microlensing measurements of 27 quasar image pairs seen through 19 lens galaxies. The Bayesian estimate for the fraction of the surface mass density in the form of stars is α = 0.21 ± 0.14 near the Einstein radius of the lenses (∼1-2 effective radii). The estimate for the average accretion disk size is R{sub 1/2}=7.9{sub −2.6}{sup +3.8}√(M/0.3 M{sub ⊙}) light days. The fraction of mass in stars at these radii is significantly largermore » than previous estimates from microlensing studies assuming quasars were point-like. The corresponding local dark matter fraction of 79% is in good agreement with other estimates based on strong lensing or kinematics. The size of the accretion disk inferred in the present study is slightly larger than previous estimates.« less

Next Generation Wiring

NASA Technical Reports Server (NTRS)

Medelius, Petro; Jolley, Scott; Fitzpatrick, Lilliana; Vinje, Rubiela; Williams, Martha; Clayton, LaNetra; Roberson, Luke; Smith, Trent; Santiago-Maldonado, Edgardo

2007-01-01

Wiring is a major operational component on aerospace hardware that accounts for substantial weight and volumetric space. Over time wire insulation can age and fail, often leading to catastrophic events such as system failure or fire. The next generation of wiring must be reliable and sustainable over long periods of time. These features will be achieved by the development of a wire insulation capable of autonomous self-healing that mitigates failure before it reaches a catastrophic level. In order to develop a self-healing insulation material, three steps must occur. First, methods of bonding similar materials must be developed that are capable of being initiated autonomously. This process will lead to the development of a manual repair system for polyimide wire insulation. Second, ways to initiate these bonding methods that lead to materials that are similar to the primary insulation must be developed. Finally, steps one and two must be integrated to produce a material that has no residues from the process that degrades the insulating properties of the final repaired insulation. The self-healing technology, teamed with the ability to identify and locate damage, will greatly improve reliability and safety of electrical wiring of critical systems. This paper will address these topics, discuss the results of preliminary testing, and remaining development issues related to self-healing wire insulation.

A framework to apply ICT for bequeathing the cultural heritage to next generation

NASA Astrophysics Data System (ADS)

Syah, R.; E Nuradi, T.; Nasution, M. K. M.

2017-01-01

Of course, preservation of cultural heritage is a task given by UNISCO charter, but bequeath the cultural heritage to the next generation is most important. The cultural heritage contains the lost intelligence, displaced by modernization and globalization, but ICT can be a way out although ICT has a negative effect. Based on the component we apply ICT, we derive a framework for applying ICT as core and next generation as consideration scope.

Next generation science standards available for comment

NASA Astrophysics Data System (ADS)

Asher, Pranoti

2012-05-01

The first public draft of the Next Generation Science Standards (NGSS) is now available for public comment. Feedback on the standards is sought from people who have a stake in science education, including individuals in the K-12, higher education, business, and research communities. Development of NGSS is a state-led effort to define the content and practices students need to learn from kindergarten through high school. NGSS will be based on the U.S. National Research Council's reportFramework for K-12 Science Education.

Design Principles of Next-Generation Digital Gaming for Education.

ERIC Educational Resources Information Center

Squire, Kurt; Jenkins, Henry; Holland, Walter; Miller, Heather; O'Driscoll, Alice; Tan, Katie Philip; Todd, Katie.

2003-01-01

Discusses the rapid growth of digital games, describes research at MIT that is exploring the potential of digital games for supporting learning, and offers hypotheses about the design of next-generation educational video and computer games. Highlights include simulations and games; and design principles, including context and using information to…

Building Next Generation Video Game Collections in Academic Libraries

ERIC Educational Resources Information Center

Laskowski, Mary; Ward, David

2009-01-01

Most academic libraries do not yet have gaming collections, let alone gaming services and facilities that support the unique and growing teaching and research needs of campus environments. Academic libraries in particular need to start thinking about developing the next generation of gaming collections and services. This article examines the…

Identification and Characterization of Key Human Performance Issues and Research in the Next Generation Air Transportation System (NextGen)

NASA Technical Reports Server (NTRS)

Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.

2010-01-01

This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.

The Next Generation Virgo Cluster Survey (NGVS). XVIII. Measurement and Calibration of Surface Brightness Fluctuation Distances for Bright Galaxies in Virgo (and Beyond)

NASA Astrophysics Data System (ADS)

Cantiello, Michele; Blakeslee, John P.; Ferrarese, Laura; Côté, Patrick; Roediger, Joel C.; Raimondo, Gabriella; Peng, Eric W.; Gwyn, Stephen; Durrell, Patrick R.; Cuillandre, Jean-Charles

2018-04-01

We describe a program to measure surface brightness fluctuation (SBF) distances to galaxies observed in the Next Generation Virgo Cluster Survey (NGVS), a photometric imaging survey covering 104 deg2 of the Virgo cluster in the u*, g, i, and z bandpasses with the Canada–France–Hawaii Telescope. We describe the selection of the sample galaxies, the procedures for measuring the apparent i-band SBF magnitude {\\overline{m}}i, and the calibration of the absolute Mibar as a function of observed stellar population properties. The multiband NGVS data set provides multiple options for calibrating the SBF distances, and we explore various calibrations involving individual color indices as well as combinations of two different colors. Within the color range of the present sample, the two-color calibrations do not significantly improve the scatter with respect to wide-baseline, single-color calibrations involving u*. We adopt the ({u}* -z) calibration as a reference for the present galaxy sample, with an observed scatter of 0.11 mag. For a few cases that lack good u* photometry, we use an alternative relation based on a combination of (g-i) and (g-z) colors, with only a slightly larger observed scatter of 0.12 mag. The agreement of our measurements with the best existing distance estimates provides confidence that our measurements are accurate. We present a preliminary catalog of distances for 89 galaxies brighter than B T ≈ 13.0 mag within the survey footprint, including members of the background M and W Clouds at roughly twice the distance of the main body of the Virgo cluster. The extension of the present work to fainter and bluer galaxies is in progress.

Interpreting the Strongly Lensed Supernova iPTF16geu: Time Delay Predictions, Microlensing, and Lensing Rates

DOE Office of Scientific and Technical Information (OSTI.GOV)

More, Anupreeta; Oguri, Masamune; More, Surhud

2017-02-01

We present predictions for time delays between multiple images of the gravitationally lensed supernova, iPTF16geu, which was recently discovered from the intermediate Palomar Transient Factory (iPTF). As the supernova is of Type Ia where the intrinsic luminosity is usually well known, accurately measured time delays of the multiple images could provide tight constraints on the Hubble constant. According to our lens mass models constrained by the Hubble Space Telescope F814W image, we expect the maximum relative time delay to be less than a day, which is consistent with the maximum of 100 hr reported by Goobar et al. but placesmore » a stringent upper limit. Furthermore, the fluxes of most of the supernova images depart from expected values suggesting that they are affected by microlensing. The microlensing timescales are small enough that they may pose significant problems to measure the time delays reliably. Our lensing rate calculation indicates that the occurrence of a lensed SN in iPTF is likely. However, the observed total magnification of iPTF16geu is larger than expected, given its redshift. This may be a further indication of ongoing microlensing in this system.« less

Next Generation * Natural Gas (NG)2 Information Requirements--Executive Summary

EIA Publications

2000-01-01

The Energy Information Administration (EIA) has initiated the Next Generation * Natural Gas (NG)2 project to design and implement a new and comprehensive information program for natural gas to meet customer requirements in the post-2000 time frame.

HLA genotyping by next-generation sequencing of complementary DNA.

PubMed

Segawa, Hidenobu; Kukita, Yoji; Kato, Kikuya

2017-11-28

Genotyping of the human leucocyte antigen (HLA) is indispensable for various medical treatments. However, unambiguous genotyping is technically challenging due to high polymorphism of the corresponding genomic region. Next-generation sequencing is changing the landscape of genotyping. In addition to high throughput of data, its additional advantage is that DNA templates are derived from single molecules, which is a strong merit for the phasing problem. Although most currently developed technologies use genomic DNA, use of cDNA could enable genotyping with reduced costs in data production and analysis. We thus developed an HLA genotyping system based on next-generation sequencing of cDNA. Each HLA gene was divided into 3 or 4 target regions subjected to PCR amplification and subsequent sequencing with Ion Torrent PGM. The sequence data were then subjected to an automated analysis. The principle of the analysis was to construct candidate sequences generated from all possible combinations of variable bases and arrange them in decreasing order of the number of reads. Upon collecting candidate sequences from all target regions, 2 haplotypes were usually assigned. Cases not assigned 2 haplotypes were forwarded to 4 additional processes: selection of candidate sequences applying more stringent criteria, removal of artificial haplotypes, selection of candidate sequences with a relaxed threshold for sequence matching, and countermeasure for incomplete sequences in the HLA database. The genotyping system was evaluated using 30 samples; the overall accuracy was 97.0% at the field 3 level and 98.3% at the G group level. With one sample, genotyping of DPB1 was not completed due to short read size. We then developed a method for complete sequencing of individual molecules of the DPB1 gene, using the molecular barcode technology. The performance of the automatic genotyping system was comparable to that of systems developed in previous studies. Thus, next-generation sequencing of

AgMIP: Next Generation Models and Assessments

NASA Astrophysics Data System (ADS)

Rosenzweig, C.

2014-12-01

Next steps in developing next-generation crop models fall into several categories: significant improvements in simulation of important crop processes and responses to stress; extension from simplified crop models to complex cropping systems models; and scaling up from site-based models to landscape, national, continental, and global scales. Crop processes that require major leaps in understanding and simulation in order to narrow uncertainties around how crops will respond to changing atmospheric conditions include genetics; carbon, temperature, water, and nitrogen; ozone; and nutrition. The field of crop modeling has been built on a single crop-by-crop approach. It is now time to create a new paradigm, moving from 'crop' to 'cropping system.' A first step is to set up the simulation technology so that modelers can rapidly incorporate multiple crops within fields, and multiple crops over time. Then the response of these more complex cropping systems can be tested under different sustainable intensification management strategies utilizing the updated simulation environments. Model improvements for diseases, pests, and weeds include developing process-based models for important diseases, frameworks for coupling air-borne diseases to crop models, gathering significantly more data on crop impacts, and enabling the evaluation of pest management strategies. Most smallholder farming in the world involves integrated crop-livestock systems that cannot be represented by crop modeling alone. Thus, next-generation cropping system models need to include key linkages to livestock. Livestock linkages to be incorporated include growth and productivity models for grasslands and rangelands as well as the usual annual crops. There are several approaches for scaling up, including use of gridded models and development of simpler quasi-empirical models for landscape-scale analysis. On the assessment side, AgMIP is leading a community process for coordinated contributions to IPCC AR6

The Next Generation Science Standards: The Features and Challenges

ERIC Educational Resources Information Center

Pruitt, Stephen L.

2014-01-01

Beginning in January of 2010, the Carnegie Corporation of New York funded a two-step process to develop a new set of state developed science standards intended to prepare students for college and career readiness in science. These new internationally benchmarked science standards, the Next Generation Science Standards (NGSS) were completed in…

International Cooperation. The Next Generation. Report of the DSMC 1990 - 1991 Military Research Fellows

DTIC Science & Technology

1991-09-01

Maintaining Goal Congruence International Cooperation-the Next Generation ENDNOTES 1. Wolfgang Flume and David Swa, "British Aerospace-Leading...Program Management Questionnaire Report. Michael G. Krause , DSMC internal document, May 1989- 10. Bonn Seminar on Armaments cooperation, proceedings, w...Appendix K 154 International Cooperation-the Next Generation Dudney, Robert S., "The Electronics Industry Flume, Wolfgang , "Electronics for the Ger- Is

DOE/NREL Next Generation Natural Gas Vehicle Program : an overview

DOT National Transportation Integrated Search

2001-05-14

This paper summarizes the Next Generation Natural Gas Vehicle (NG-NGV) Program that is led by the U.S. Department Of Energys (DOEs) Office of Heavy Vehicle Technologies (OHVT) through the National Renewable Energy Laboratory (NREL). The goal of...

Career Advancement: Meeting the Challenges Confronting the Next Generation of Endocrinologists and Endocrine Researchers.

PubMed

Santen, Richard J; Joham, Anju; Fishbein, Lauren; Vella, Kristen R; Ebeling, Peter R; Gibson-Helm, Melanie; Teede, Helena

2016-12-01

Challenges and opportunities face the next generation (Next-Gen) of endocrine researchers and clinicians, the lifeblood of the field of endocrinology for the future. A symposium jointly sponsored by The Endocrine Society and the Endocrine Society of Australia was convened to discuss approaches to addressing the present and future Next-Gen needs. Data collection by literature review, assessment of previously completed questionnaires, commissioning of a new questionnaire, and summarization of symposium discussions were studied. Next-Gen endocrine researchers face diminishing grant funding in inflation-adjusted terms. The average age of individuals being awarded their first independent investigator funding has increased to age 45 years. For clinicians, a workforce gap exists between endocrinologists needed and those currently trained. Clinicians in practice are increasingly becoming employees of integrated hospital systems, resulting in greater time spent on nonclinical issues. Workforce data and published reviews identify challenges specifically related to early career women in endocrinology. Strategies to Address Issues: Recommendations encompassed the areas of grant support for research, mentoring, education, templates for career development, specific programs for Next-Gen members by senior colleagues as outlined in the text, networking, team science, and life/work integration. Endocrine societies focusing on Next-Gen members provide a powerful mechanism to support these critical areas. A concerted effort to empower, train, and support the next generation of clinical endocrinologists and endocrine researchers is necessary to ensure the viability and vibrancy of our discipline and to optimize our contributions to improving health outcomes. Collaborative engagement of endocrine societies globally will be necessary to support our next generation moving forward.

"ASTRO 101" Course Materials 2.0: Next Generation Lecture Tutorials and Beyond

NASA Astrophysics Data System (ADS)

Slater, Stephanie; Grazier, Kevin

2015-01-01

Early efforts to create course materials were often local in scale and were based on "gut instinct," and classroom experience and observation. While subsequent efforts were often based on those same instincts and observations of classrooms, they also incorporated the results of many years of education research. These "second generation" course materials, such as lecture tutorials, relied heavily on research indicating that instructors need to actively engage students in the learning process. While imperfect, these curricular innovations, have provided evidence that research-based materials can be constructed, can easily be disseminated to a broad audience, and can provide measureable improvement in student learning across many settings. In order to improve upon this prior work, next generation materials must build upon the strengths of these innovations while engineering in findings from education research, cognitive science, and instructor feedback. A next wave of materials, including a set of next generation lecture tutorials, have been constructed with attention to the body of research on student motivation, and cognitive load; and they are responsive to our body of knowledge on learning difficulties related to specific content in the domain. From instructor feedback, these materials have been constructed to have broader coverage of the materials typically taught in an ASTRO 101 course, to take less class time, and to be more affordable for students. This next generation of lecture tutorials may serve as a template of the ways in which course materials can be reengineered to respond to current instructor and student needs.

Next generation 9-1-1 system : preliminary concept of operations.

DOT National Transportation Integrated Search

2005-12-01

The purpose of this document is to provide a preliminary Concept of Operations for the : Next Generation (NG9-1-1) system (or system of systems). The U.S. Department of : Transportation (DOT) understands that access to emergency services provid...

Tablet—next generation sequence assembly visualization

PubMed Central

Milne, Iain; Bayer, Micha; Cardle, Linda; Shaw, Paul; Stephen, Gordon; Wright, Frank; Marshall, David

2010-01-01

Summary: Tablet is a lightweight, high-performance graphical viewer for next-generation sequence assemblies and alignments. Supporting a range of input assembly formats, Tablet provides high-quality visualizations showing data in packed or stacked views, allowing instant access and navigation to any region of interest, and whole contig overviews and data summaries. Tablet is both multi-core aware and memory efficient, allowing it to handle assemblies containing millions of reads, even on a 32-bit desktop machine. Availability: Tablet is freely available for Microsoft Windows, Apple Mac OS X, Linux and Solaris. Fully bundled installers can be downloaded from http://bioinf.scri.ac.uk/tablet in 32- and 64-bit versions. Contact: tablet@scri.ac.uk PMID:19965881

Next Generation CAD/CAM/CAE Systems

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler); Malone, John B. (Compiler)

1997-01-01

This document contains presentations from the joint UVA/NASA Workshop on Next Generation CAD/CAM/CAE Systems held at NASA Langley Research Center in Hampton, Virginia on March 18-19, 1997. The presentations focused on current capabilities and future directions of CAD/CAM/CAE systems, aerospace industry projects, and university activities related to simulation-based design. Workshop attendees represented NASA, commercial software developers, the aerospace industry, government labs, and academia. The workshop objectives were to assess the potential of emerging CAD/CAM/CAE technology for use in intelligent simulation-based design and to provide guidelines for focused future research leading to effective use of CAE systems for simulating the entire life cycle of aerospace systems.

Insulating Material for Next-Generation Spacecraft

NASA Technical Reports Server (NTRS)

White, Susan; Johnson, Sylvia; Salerno, Louis; Kittel, Peter; Roach, Pat; Helvensteijn, Ben; Kashani, Ali

2006-01-01

A report discusses the development of a flexible thermal-insulation material for cryogenic tanks in next-generation spacecraft. This material is denoted Advanced Reusable All-temperature Multimode Insulation System (ARAMIS). The report begins by describing the need for ARAMIS and the technological challenges of developing a single material that is useable throughout the temperature range from storage of liquid hydrogen (20 K) to atmospheric-reentry heating (>2,000 K), has the requisite low thermal conductivity, resists condensation of moisture without need for a gas purge, and withstands reentry heating for a 400-mission lifetime. The report then discusses laboratory apparatuses for testing materials that have been and will be considered as candidates for the development of ARAMIS.

OGLE-2015-BLG-1459L: The Challenges of Exo-moon Microlensing

NASA Astrophysics Data System (ADS)

Hwang, K.-H.; Udalski, A.; Bond, I. A.; Albrow, M. D.; Chung, S.-J.; Gould, A.; Han, C.; Jung, Y. K.; Ryu, Y.-H.; Shin, I.-G.; Yee, J. C.; Zhu, W.; Cha, S.-M.; Kim, D.-J.; Kim, H.-W.; Kim, S.-L.; Lee, C.-U.; Lee, D.-J.; Lee, Y.; Park, B.-G.; Pogge, R. W.; KMTNet Collaboration; Pawlak, M.; Poleski, R.; Szymański, M. K.; Skowron, J.; Soszyński, I.; Mróz, P.; Kozłowski, S.; Pietrukowicz, P.; Ulaczyk, K.; OGLE Collaboration; Abe, F.; Asakura, Y.; Barry, R.; Bennett, D. P.; Bhattacharya, A.; Donachie, M.; Evans, P.; Fukui, A.; Hirao, Y.; Itow, Y.; Kawasaki, K.; Koshimoto, N.; Li, M. C. A.; Ling, C. H.; Masuda, K.; Matsubara, Y.; Miyazaki, S.; Muraki, Y.; Nagakane, M.; Ohnishi, K.; Ranc, C.; Rattenbury, N. J.; Saito, To.; Sharan, A.; Sullivan, D. J.; Sumi, T.; Suzuki, D.; Tristram, P. J.; Yamada, T.; Yamada, T.; Yonehara, A.; MOA Collaboration

2018-06-01

We show that dense OGLE and KMTNet I-band survey data require four bodies (sources plus lenses) to explain the microlensing light curve of OGLE-2015-BLG-1459. However, these can equally well consist of three lenses and one source (3L1S), two lenses and two sources (2L2S), or one lens and three sources (1L3S). In the 3L1S and 2L2S interpretations, the host is a brown dwarf and the dominant companion is a Neptune-class planet, with the third body (in the 3L1S case) being a Mars-class object that could have been a moon of the planet. In the 1L3S solution, the light curve anomalies are explained by a tight (five stellar radii) low-luminosity binary source that is offset from the principal source of the event by ∼ 0.17 {au}. These degeneracies are resolved in favor of the 1L3S solution by color effects derived from comparison to MOA data, which are taken in a slightly different (R/I) passband. To enable current and future (WFIRST) surveys to routinely characterize exo-moons and distinguish among such exotic systems requires an observing strategy that includes both a cadence faster than 9 minute‑1 and observations in a second band on a similar timescale.

Advancing Next-Generation Energy in Indian Country (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2012-08-01

This fact sheet provides information on the Alaska Native governments selected to receive assistance from the Strategic Technical Assistance Response Team (START) Program, a U.S. Department of Energy Office of Indian Energy Policy and Programs (DOE-IE) initiative to provide technical expertise to support the development of next-generation energy projects in Indian Country.

Promising Practices: Building the Next Generation of School Leaders

ERIC Educational Resources Information Center

Bryant, Jennifer Edic; Escalante, Karen; Selva, Ashley

2017-01-01

This study applies transformational leadership theory practices to examine the purposeful ways in which principals work to build the next generation of teacher leaders in response to the shortage of K-12 principals. Given the impact principals have on student development and the shortage of those applying for the principalship, the purpose of this…

The Next Generation Space Telescope (NGST): Science and technology

NASA Technical Reports Server (NTRS)

Mather, John C.; Seery, Bernard D.; Stockman, Hervey S.; Bely, Pierre, Y.

1997-01-01

The scientific requirements and implications for the instruments and telescope design for the Next Generation Space Telescope (NGST) are described. A candidate concept is a deployable, 8 m diameter telescope, optimized for the near infrared region, but featuring instruments capable of observing up to 30 micrometers. The observatory is radiatively cooled to approximately 30 K.

Next-generation optical wireless communications for data centers

NASA Astrophysics Data System (ADS)

Arnon, Shlomi

2015-01-01

Data centers collect and process information with a capacity that has been increasing from year to year at an almost exponential pace. Traditional fiber/cable data center network interconnections suffer from bandwidth overload, as well as flexibility and scalability issues. Therefore, a technology-shift from the fiber and cable to wireless has already been initiated in order to meet the required data-rate, flexibility and scalability demands for next-generation data center network interconnects. In addition, the shift to wireless reduces the volume allocated to the cabling/fiber and increases the cooling efficiency. Optical wireless communication (OWC), or free space optics (FSO), is one of the most effective wireless technologies that could be used in future data centers and could provide ultra-high capacity, very high cyber security and minimum latency, due to the low index of refraction of air in comparison to fiber technologies. In this paper we review the main concepts and configurations for next generation OWC for data centers. Two families of technologies are reviewed: the first technology regards interconnects between rack units in the same rack and the second technology regards the data center network that connects the server top of rack (TOR) to the switch. A comparison between different network technologies is presented.

Standardization and quality management in next-generation sequencing.

PubMed

Endrullat, Christoph; Glökler, Jörn; Franke, Philipp; Frohme, Marcus

2016-09-01

DNA sequencing continues to evolve quickly even after > 30 years. Many new platforms suddenly appeared and former established systems have vanished in almost the same manner. Since establishment of next-generation sequencing devices, this progress gains momentum due to the continually growing demand for higher throughput, lower costs and better quality of data. In consequence of this rapid development, standardized procedures and data formats as well as comprehensive quality management considerations are still scarce. Here, we listed and summarized current standardization efforts and quality management initiatives from companies, organizations and societies in form of published studies and ongoing projects. These comprise on the one hand quality documentation issues like technical notes, accreditation checklists and guidelines for validation of sequencing workflows. On the other hand, general standard proposals and quality metrics are developed and applied to the sequencing workflow steps with the main focus on upstream processes. Finally, certain standard developments for downstream pipeline data handling, processing and storage are discussed in brief. These standardization approaches represent a first basis for continuing work in order to prospectively implement next-generation sequencing in important areas such as clinical diagnostics, where reliable results and fast processing is crucial. Additionally, these efforts will exert a decisive influence on traceability and reproducibility of sequence data.

Next generation sequencing applications for breast cancer research

PubMed Central

PETRIC, ROXANA COJOCNEANU; POP, LAURA-ANCUTA; JURJ, ANCUTA; RADULY, LAJOS; DUMITRASCU, DAN; DRAGOS, NICOLAE; NEAGOE, IOANA BERINDAN

2015-01-01

For some time, cancer has not been thought of as a disease, but as a multifaceted, heterogeneous complex of genotypic and phenotypic manifestations leading to tumorigenesis. Due to recent technological progress, the outcome of cancer patients can be greatly improved by introducing in clinical practice the advantages brought about by the development of next generation sequencing techniques. Biomedical suppliers have come up with various applications which medical researchers can use to characterize a patient’s disease from molecular and genetic point of view in order to provide caregivers with rapid and relevant information to guide them in choosing the most appropriate course of treatment, with maximum efficiency and minimal side effects. Breast cancer, whose incidence has risen dramatically, is a good candidate for these novel diagnosis and therapeutic approaches, particularly when referring to specific sequencing panels which are designed to detect germline or somatic mutations in genes that are involved in breast cancer tumorigenesis and progression. Benchtop next generation sequencing machines are becoming a more common presence in the clinical setting, empowering physicians to better treat their patients, by offering early diagnosis alternatives, targeted remedies, and bringing medicine a step closer to achieving its ultimate goal, personalized therapy. PMID:26609257

Commercialization and internationalization of the next-generation launch system

NASA Astrophysics Data System (ADS)

Bille, Matthew A.; Richie, George E.; Bille, Deborah A.

1996-03-01

The United States, ESA, Russia, and Japan are all pursuing the goal of a next-generation launch system. However, economic constraints may ground these programs, as they did hypersonic spaceplane efforts. In today's constrained fiscal environment, engineering is secondary unless the most practical economic and political approach is also found. While international efforts face national concerns over jobs and competitiveness, low-cost access to orbit will open up space to whole new industries. In the long run, all involved nations will gain economically if a next-generation launcher is built, and all will lose if individual efforts fail. An international consortium is most likely to amass the resources needed. The consortium would not be dedicated to any single technical concept, but would select from industry proposals to design and build the technology demonstrator. The goal is to get one working system built: after that, it is not critical whether we have one cooperative operational system or a dozen competing ones. What is critical is not to miss another chance to launch the era of space commercialization.

An Open-Source Galaxy Redshift Survey Simulator for next-generation Large Scale Structure Surveys

NASA Astrophysics Data System (ADS)

Seijak, Uros

Galaxy redshift surveys produce three-dimensional maps of the galaxy distribution. On large scales these maps trace the underlying matter fluctuations in a relatively simple manner, so that the properties of the primordial fluctuations along with the overall expansion history and growth of perturbations can be extracted. The BAO standard ruler method to measure the expansion history of the universe using galaxy redshift surveys is thought to be robust to observational artifacts and understood theoretically with high precision. These same surveys can offer a host of additional information, including a measurement of the growth rate of large scale structure through redshift space distortions, the possibility of measuring the sum of neutrino masses, tighter constraints on the expansion history through the Alcock-Paczynski effect, and constraints on the scale-dependence and non-Gaussianity of the primordial fluctuations. Extracting this broadband clustering information hinges on both our ability to minimize and subtract observational systematics to the observed galaxy power spectrum, and our ability to model the broadband behavior of the observed galaxy power spectrum with exquisite precision. Rapid development on both fronts is required to capitalize on WFIRST's data set. We propose to develop an open-source computational toolbox that will propel development in both areas by connecting large scale structure modeling and instrument and survey modeling with the statistical inference process. We will use the proposed simulator to both tailor perturbation theory and fully non-linear models of the broadband clustering of WFIRST galaxies and discover novel observables in the non-linear regime that are robust to observational systematics and able to distinguish between a wide range of spatial and dynamic biasing models for the WFIRST galaxy redshift survey sources. We have demonstrated the utility of this approach in a pilot study of the SDSS-III BOSS galaxies, in which we

Advancing Next-Generation Energy in Indian Country (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2012-08-01

This fact sheet provides information on Tribes in the lower 48 states selected to receive assistance from the Strategic Technical Assistance Response Team (START) Program, a U.S. Department of Energy Office of Indian Energy Policy and Programs (DOE-IE) initiative to provide technical expertise to support the development of next-generation energy projects in Indian Country.

Coinfection of Fusobacterium nucleatum and Actinomyces israelii in Mastoiditis Diagnosed by Next-Generation DNA Sequencing

PubMed Central

Hoogestraat, Daniel R.; Abbott, April N.; SenGupta, Dhruba J.; Cummings, Lisa A.; Butler-Wu, Susan M.; Stephens, Karen; Cookson, Brad T.; Hoffman, Noah G.

2014-01-01

Some bacterial infections involve potentially complex mixtures of species that can now be distinguished using next-generation DNA sequencing. We present a case of mastoiditis where Gram stain, culture, and molecular diagnosis were nondiagnostic or discrepant. Next-generation sequencing implicated coinfection of Fusobacterium nucleatum and Actinomyces israelii, resolving these diagnostic discrepancies. PMID:24574281

Novel CAD/CAM rapid prototyping of next-generation biomedical devices

NASA Astrophysics Data System (ADS)

Doraiswamy, Anand

An aging population with growing healthcare needs demands multifaceted tools for diagnosis and treatment of health conditions. In the near-future, drug-administration devices, implantable devices/sensors, enhanced prosthesis, artificial and unique functional tissue constructs will become increasingly significant. Conventional technologies for mass-produced implants do not adequately take individual patient anatomy into consideration. Development of novel CAD/CAM rapid prototyping techniques may significantly accelerate progress of these devices for next-generation patient-care. In this dissertation, several novel rapid prototyping techniques have been introduced for next-generation biomedical applications. Two-photon polymerization was developed to microfabricate scaffolds for tissue engineering, microneedles for drug-delivery and ossicular replacement prostheses. Various photoplymers were evaluated for feasibility, mechanical properties, cytotoxicity, and surface properties. Laser direct write using MDW was utilized for developing microstructures of bioceramics such as hydroxyapatite, and viable mammalian osteosarcoma cells. CAD/CAM laser micromachining (CLM) was developed to engineer biointerfaces as surface recognition regions for differential adherence of cells and growth into tissue-like networks. CLM was also developed for engineering multi-cellular vascular networks. Cytotoxic evaluations and growth studies demonstrated VEGF-induced proliferation of HAAE-1 human aortic endothelial cells with inhibition of HA-VSMC human aortic smooth muscle cells. Finally, piiezoelectric inkjet printing was developed for controlled administration of natural and synthetic adhesives to overcome several problems associated with conventional tissue bonding materials, and greatly improve wound-repair in next generation eye repair, fracture fixation, organ fixation, wound closure, tissue engineering, and drug delivery devices.

Screening for SNPs with Allele-Specific Methylation based on Next-Generation Sequencing Data.

PubMed

Hu, Bo; Ji, Yuan; Xu, Yaomin; Ting, Angela H

2013-05-01

Allele-specific methylation (ASM) has long been studied but mainly documented in the context of genomic imprinting and X chromosome inactivation. Taking advantage of the next-generation sequencing technology, we conduct a high-throughput sequencing experiment with four prostate cell lines to survey the whole genome and identify single nucleotide polymorphisms (SNPs) with ASM. A Bayesian approach is proposed to model the counts of short reads for each SNP conditional on its genotypes of multiple subjects, leading to a posterior probability of ASM. We flag SNPs with high posterior probabilities of ASM by accounting for multiple comparisons based on posterior false discovery rates. Applying the Bayesian approach to the in-house prostate cell line data, we identify 269 SNPs as candidates of ASM. A simulation study is carried out to demonstrate the quantitative performance of the proposed approach.

Screening for SNPs with Allele-Specific Methylation based on Next-Generation Sequencing Data

PubMed Central

Hu, Bo; Xu, Yaomin

2013-01-01

Allele-specific methylation (ASM) has long been studied but mainly documented in the context of genomic imprinting and X chromosome inactivation. Taking advantage of the next-generation sequencing technology, we conduct a high-throughput sequencing experiment with four prostate cell lines to survey the whole genome and identify single nucleotide polymorphisms (SNPs) with ASM. A Bayesian approach is proposed to model the counts of short reads for each SNP conditional on its genotypes of multiple subjects, leading to a posterior probability of ASM. We flag SNPs with high posterior probabilities of ASM by accounting for multiple comparisons based on posterior false discovery rates. Applying the Bayesian approach to the in-house prostate cell line data, we identify 269 SNPs as candidates of ASM. A simulation study is carried out to demonstrate the quantitative performance of the proposed approach. PMID:23710259

76 FR 2109 - Next Generation Risk Assessment Public Dialogue Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9246-7] Next Generation Risk Assessment Public Dialogue Conference Correction In notice document 2010-32977 appearing on page 82387 in the issue of Thursday, December 30, 2010, make the following correction: In the second column, below the signature date, the...

Gravitational Microlensing Observations of Two New Exoplanets Using the Deep Impact High Resolution Instrument

NASA Astrophysics Data System (ADS)

Barry, Richard K.; Bennett, D. P.; Klaasen, K.; Becker, A. C.; Christiansen, J.; Albrow, M.

2014-01-01

We have worked to characterize two exoplanets newly detected from the ground: OGLE-2012-BLG-0406 and OGLE-2012-BLG-0838, using microlensing observations of the Galactic Bulge recently obtained by NASA’s Deep Impact (DI) spacecraft, in combination with ground data. These observations of the crowded Bulge fields from Earth and from an observatory at a distance of ~1 AU have permitted the extraction of a microlensing parallax signature - critical for breaking exoplanet model degeneracies. For this effort, we used DI’s High Resolution Instrument, launched with a permanent defocus aberration due to an error in cryogenic testing. We show how the effects of a very large, chromatic PSF can be reduced in differencing photometry. We also compare two approaches to differencing photometry - one of which employs the Bramich algorithm and another using the Fruchter & Hook drizzle algorithm.

Adaptive liquid microlenses activated by stimuli-responsive hydrogels.

PubMed

Dong, Liang; Agarwal, Abhishek K; Beebe, David J; Jiang, Hongrui

2006-08-03

Despite its compactness, the human eye can easily focus on different distances by adjusting the shape of its lens with the help of ciliary muscles. In contrast, traditional man-made optical systems achieve focusing by physical displacement of the lenses used. But in recent years, advances in miniaturization technology have led to optical systems that no longer require complicated mechanical systems to tune and adjust optical performance. These systems have found wide use in photonics, displays and biomedical systems. They are either based on arrays of microlenses with fixed focal lengths, or use external control to adjust the microlens focal length. An intriguing example is the tunable liquid lens, where electrowetting or external pressure manipulates the shape of a liquid droplet and thereby adjusts its optical properties. Here we demonstrate a liquid lens system that allows for autonomous focusing. The central component is a stimuli-responsive hydrogel integrated into a microfluidic system and serving as the container for a liquid droplet, with the hydrogel simultaneously sensing the presence of stimuli and actuating adjustments to the shape--and hence focal length--of the droplet. By working at the micrometre scale where ionic diffusion and surface tension scale favourably, we can use pinned liquid-liquid interfaces to obtain stable devices and realize response times of ten to a few tens of seconds. The microlenses, which can have a focal length ranging from -infinity to +infinity (divergent and convergent), are also readily integrated into arrays that may find use in applications such as sensing, medical diagnostics and lab-on-a-chip technologies.

Adaptive liquid microlenses activated by stimuli-responsive hydrogels

NASA Astrophysics Data System (ADS)

Dong, Liang; Agarwal, Abhishek K.; Beebe, David J.; Jiang, Hongrui

2006-08-01

Despite its compactness, the human eye can easily focus on different distances by adjusting the shape of its lens with the help of ciliary muscles. In contrast, traditional man-made optical systems achieve focusing by physical displacement of the lenses used. But in recent years, advances in miniaturization technology have led to optical systems that no longer require complicated mechanical systems to tune and adjust optical performance. These systems have found wide use in photonics, displays and biomedical systems. They are either based on arrays of microlenses with fixed focal lengths, or use external control to adjust the microlens focal length. An intriguing example is the tunable liquid lens, where electrowetting or external pressure manipulates the shape of a liquid droplet and thereby adjusts its optical properties. Here we demonstrate a liquid lens system that allows for autonomous focusing. The central component is a stimuli-responsive hydrogel integrated into a microfluidic system and serving as the container for a liquid droplet, with the hydrogel simultaneously sensing the presence of stimuli and actuating adjustments to the shape-and hence focal length-of the droplet. By working at the micrometre scale where ionic diffusion and surface tension scale favourably, we can use pinned liquid-liquid interfaces to obtain stable devices and realize response times of ten to a few tens of seconds. The microlenses, which can have a focal length ranging from -∞ to +∞ (divergent and convergent), are also readily integrated into arrays that may find use in applications such as sensing, medical diagnostics and lab-on-a-chip technologies.

Possible Nuclear Safeguards Applications: Workshop on Next-Generation Laser Compton Gamma Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durham, J. Matthew

2016-11-17

These are a set of slides for the development of a next-generation photon source white paper. The following topics are covered in these slides: Nuclear Safeguards; The Nuclear Fuel Cycle; Precise isotopic determination via NRF; UF 6 Enrichment Assay; and Non-Destructive Assay of Spent Nuclear Fuel. In summary: A way to non-destructively measure precise isotopics of ~kg and larger samples has multiple uses in nuclear safeguards; Ideally this is a compact, fieldable device that can be used by international inspectors. Must be rugged and reliable; A next-generation source can be used as a testing ground for these techniques as technologymore » develops.« less

Next generation locomotive cab task 5 summary report : control stand design.

DOT National Transportation Integrated Search

2010-07-01

This report discusses the development of a user-centered control stand for the Federal Railroad Administrations Next Generation Locomotive Cab Demonstration Program. A modified Association of American Railroads 105 side-mounted control stand...

Next generation platforms for high-throughput biodosimetry

PubMed Central

Repin, Mikhail; Turner, Helen C.; Garty, Guy; Brenner, David J.

2014-01-01

Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of biodosimetry assays was described. These platforms can be used at different stages of biodosimetry assays starting from blood collection into microtubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multiwell and multichannel plates. Robotically friendly platforms can be used for different biodosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems. PMID:24837249

RED NOISE VERSUS PLANETARY INTERPRETATIONS IN THE MICROLENSING EVENT OGLE-2013-BLG-446

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bachelet, E.; Bramich, D. M.; AlSubai, K.

2015-10-20

For all exoplanet candidates, the reliability of a claimed detection needs to be assessed through a careful study of systematic errors in the data to minimize the false positives rate. We present a method to investigate such systematics in microlensing data sets using the microlensing event OGLE-2013-BLG-0446 as a case study. The event was observed from multiple sites around the world and its high magnification (A{sub max} ∼ 3000) allowed us to investigate the effects of terrestrial and annual parallax. Real-time modeling of the event while it was still ongoing suggested the presence of an extremely low-mass companion (∼3M{sub ⨁})more » to the lensing star, leading to substantial follow-up coverage of the light curve. We test and compare different models for the light curve and conclude that the data do not favor the planetary interpretation when systematic errors are taken into account.« less

Practical applications of next-generation sequencing for food-safety research

USDA-ARS?s Scientific Manuscript database

Next-generation sequencing (NGS) is a transformative technology that is revolutionizing the biological sciences. However, many researchers remain uncertain as to the best ways to harness the power of NGS and apply it to their own research questions. Here we highlight three case studies of how NGS ...

Next-generation all-silica coatings for UV applications

NASA Astrophysics Data System (ADS)

Melninkaitis, A.; Grinevičiūtė, L.; Abromavičius, G.; Mažulė, L.; Smalakys, L.; Pupka, E.; Š čiuka, M.; Buzelis, R.; Kičas, S.

2017-11-01

Band-gap and refractive index are known as fundamental properties determining intrinsic optical resistance of multilayer dielectric coatings. By considering this fact we propose novel approach to manufacturing of interference thin films, based on artificial nano-structures of modulated porosity embedded in high band-gap matrix. Next generation all-silica mirrors were prepared by GLancing Angle Deposition (GLAD) using electron beam evaporation. High reflectivity (HR) was achieved by tailoring the porosity of highly resistant silica material during the thin film deposition process. Furthermore, the proposed approach was also demonstrated to work well in case of anti-reflection (AR) coatings. Conventional HR HfO2 and SiO2 as well as AR Al2O3 and SiO2 multilayers produced by Ion Beam Sputtering (IBS) were used as reference coatings. Damage performance of experimental coatings was also analyzed. All-silica based GLAD approach resulted in significant improvement of intrinsic laser damage resistance properties if compared to conventional coatings. Besides laser damage testing, other characteristics of experimental coatings are analyzed and discussed - reflectance, surface roughness and optical scattering. We believe that reported concept can be expanded to virtually any design of thin film coatings thus opening a new way of next generation highly resistant thin films well suited for high power and UV laser applications.

Spitzer Opens New Path to Break Classic Degeneracy for Jupiter-mass Microlensing Planet OGLE-2017-BLG-1140Lb

NASA Astrophysics Data System (ADS)

Calchi Novati, S.; Skowron, J.; Jung, Y. K.; Beichman, C.; Bryden, G.; Carey, S.; Gaudi, B. S.; Henderson, C. B.; Shvartzvald, Y.; Yee, J. C.; Zhu, W.; Spitzer Team; Udalski, A.; Szymański, M. K.; Mróz, P.; Poleski, R.; Soszyński, I.; Kozłowski, S.; Pietrukowicz, P.; Ulaczyk, K.; Pawlak, M.; Rybicki, K.; Iwanek, P.; OGLE Collaboration; Albrow, M. D.; Chung, S.-J.; Gould, A.; Han, C.; Hwang, K.-H.; Ryu, Y.-H.; Shin, I.-G.; Zang, W.; Cha, S.-M.; Kim, D.-J.; Kim, H.-W.; Kim, S.-L.; Lee, C.-U.; Lee, D.-J.; Lee, Y.; Park, B.-G.; Pogge, R. W.; KMTNet Collaboration

2018-06-01

We analyze the combined Spitzer and ground-based data for OGLE-2017-BLG-1140 and show that the event was generated by a Jupiter-class ({m}p≃ 1.6 {M}{{J}{{u}}{{p}}}) planet orbiting a mid-late M dwarf (M≃ 0.2 {M}ȯ ) that lies {D}LS}≃ 1.0 {kpc} in the foreground of the microlensed Galactic-bar source star. The planet–host projected separation is {a}\\perp ≃ 1.0 {au}, i.e., well beyond the snow line. By measuring the source proper motion {{\\boldsymbol{μ }}}s from ongoing long-term OGLE imaging and combining this with the lens-source relative proper motion {{\\boldsymbol{μ }}}rel} derived from the microlensing solution, we show that the lens proper motion {{\\boldsymbol{μ }}}l={{\\boldsymbol{μ }}}rel}+{{\\boldsymbol{μ }}}s is consistent with the lens lying in the Galactic disk, although a bulge lens is not ruled out. We show that while the Spitzer and ground-based data are comparably well fitted by planetary (i.e., binary-lens (2L1S)) and binary-source (1L2S) models, the combination of Spitzer and ground-based data decisively favors the planetary model. This is a new channel to resolve the 2L1S/1L2S degeneracy, which can be difficult to break in some cases.

SNAP: Small Next-generation Atmospheric Probe Concept

NASA Astrophysics Data System (ADS)

Sayanagi, K. M.; Dillman, R. A.; Atkinson, D. H.; Li, J.; Saikia, S.; Simon, A. A.; Spilker, T. R.; Wong, M. H.; Hope, D.

2017-12-01

We present a concept for a small, atmospheric probe that could be flexibly added to future missions that orbit or fly-by a giant planet as a secondary payload, which we call the Small Next-generation Atmospheric Probe (SNAP). SNAP's main scientific objectives are to determine the vertical distribution of clouds and cloud-forming chemical species, thermal stratification, and wind speed as a function of depth. As a case study, we present the advantages, cost and risk of adding SNAP to the future Uranus Orbiter and Probe flagship mission; in combination with the mission's main probe, SNAP would perform atmospheric in-situ measurements at a second location, and thus enable and enhance the scientific objectives recommended by the 2013 Planetary Science Decadal Survey and the 2014 NASA Science Plan to determine atmospheric spatial variabilities. We envision that the science objectives can be achieved with a 30-kg entry probe 0.5m in diameter (less than half the size of the Galileo probe) that reaches 5-bar pressure-altitude and returns data to Earth via the carrier spacecraft. As the baseline instruments, the probe will carry an Atmospheric Structure Instrument (ASI) that measures the temperature, pressure and acceleration, a carbon nanotube-based NanoChem atmospheric composition sensor, and an Ultra-Stable Oscillator (USO) to conduct a Doppler Wind Experiment (DWE). We also catalog promising technologies currently under development that will strengthen small atmospheric entry probe missions in the future. While SNAP is applicable to multiple planets, we examine the feasibility, benefits and impacts of adding SNAP to the Uranus Orbiter and Probe flagship mission. Our project is supported by NASA PSDS3 grant NNX17AK31G.

Targeted next generation sequencing for the detection of ciprofloxacin resistance markers using molecular inversion probes

DTIC Science & Technology

2016-07-06

1 Targeted next-generation sequencing for the detection of ciprofloxacin resistance markers using molecular inversion probes Christopher P...development and evaluation of a panel of 44 single-stranded molecular inversion probes (MIPs) coupled to next-generation sequencing (NGS) for the...padlock and molecular inversion probes as upfront enrichment steps for use with NGS showed the specificity and multiplexability of these techniques

Compact 2100 nm laser diode module for next-generation DIRCM

NASA Astrophysics Data System (ADS)

Dvinelis, Edgaras; Greibus, Mindaugas; TrinkÅ«nas, Augustinas; NaujokaitÄ--, Greta; Vizbaras, Augustinas; Vizbaras, Dominykas; Vizbaras, Kristijonas

2017-10-01

Compact high-power 2100 nm laser diode module for next-generation directional infrared countermeasure (DIRCM) systems is presented. Next-generation DIRCM systems require compact, light-weight and robust laser modules which could provide intense IR light emission capable of disrupting the tracking sensor of heat-seeking missile. Currently used solid-state and fiber laser solutions for mid-IR band are bulky and heavy making them difficult to implement in smaller form-factor DIRCM systems. Recent development of GaSb laser diode technology greatly improved optical output powers and efficiencies of laser diodes working in 1900 - 2450 nm band [1] while also maintaining very attractive size, weight, power consumption and cost characteristics. 2100 nm laser diode module presented in this work performance is based on high-efficiency broad emitting area GaSb laser diode technology. Each laser diode emitter is able to provide 1 W of CW output optical power with working point efficiency up to 20% at temperature of 20 °C. For output beam collimation custom designed fast-axis collimator and slow-axis collimator lenses were used. These lenses were actively aligned and attached using UV epoxy curing. Total 2 emitters stacked vertically were used in 2100 nm laser diode module. Final optical output power of the module goes up to 2 W at temperature of 20 °C. Total dimensions of the laser diode module are 35 x 25 x 16 mm (L x W x H) with a weight of 28 grams. Finally output beam is bore-sighted to mechanical axes of the module housing allowing for easy integration into next-generation DIRCM systems.

Next Generation Virgo Cluster Survey. XXI. The Weak Lensing Masses of the CFHTLS and NGVS RedGOLD Galaxy Clusters and Calibration of the Optical Richness

NASA Astrophysics Data System (ADS)

Parroni, Carolina; Mei, Simona; Erben, Thomas; Van Waerbeke, Ludovic; Raichoor, Anand; Ford, Jes; Licitra, Rossella; Meneghetti, Massimo; Hildebrandt, Hendrik; Miller, Lance; Côté, Patrick; Covone, Giovanni; Cuillandre, Jean-Charles; Duc, Pierre-Alain; Ferrarese, Laura; Gwyn, Stephen D. J.; Puzia, Thomas H.

2017-10-01

We measured stacked weak lensing cluster masses for a sample of 1323 galaxy clusters detected by the RedGOLD algorithm in the Canada-France-Hawaii Telescope Legacy Survey W1 and the Next Generation Virgo Cluster Survey at 0.2< z< 0.5, in the optical richness range 10< λ < 70. This is the most comprehensive lensing study of a ˜ 100 % complete and ˜ 80 % pure optical cluster catalog in this redshift range. We test different mass models, and our final model includes a basic halo model with a Navarro Frenk and White profile, as well as correction terms that take into account cluster miscentering, non-weak shear, the two-halo term, the contribution of the Brightest Cluster Galaxy, and an a posteriori correction for the intrinsic scatter in the mass-richness relation. With this model, we obtain a mass-richness relation of {log}{M}200/{M}⊙ =(14.46+/- 0.02)+(1.04+/- 0.09){log}(λ /40) (statistical uncertainties). This result is consistent with other published lensing mass-richness relations. We give the coefficients of the scaling relations between the lensing mass and X-ray mass proxies, L X and T X, and compare them with previous results. When compared to X-ray masses and mass proxies, our results are in agreement with most previous results and simulations, and consistent with the expected deviations from self-similarity.

JVM: Java Visual Mapping tool for next generation sequencing read.

PubMed

Yang, Ye; Liu, Juan

2015-01-01

We developed a program JVM (Java Visual Mapping) for mapping next generation sequencing read to reference sequence. The program is implemented in Java and is designed to deal with millions of short read generated by sequence alignment using the Illumina sequencing technology. It employs seed index strategy and octal encoding operations for sequence alignments. JVM is useful for DNA-Seq, RNA-Seq when dealing with single-end resequencing. JVM is a desktop application, which supports reads capacity from 1 MB to 10 GB.

Chromaticity of gravitational microlensing events

NASA Astrophysics Data System (ADS)

Han, Cheongho; Park, Seong-Hong; Jeong, Jang-Hae

2000-07-01

In this paper, we investigate the colour changes of gravitational microlensing events caused by the two different mechanisms of differential amplification for a limb-darkened extended source and blending. From this investigation, we find that the colour changes of limb-darkened extended source events (colour curves) have dramatically different characteristics depending on whether the lens transits the source star or not. We show that for a source transit event, the lens proper motion can be determined by simply measuring the turning time of the colour curve instead of fitting the overall colour or light curves. We also find that even for a very small fraction of blended light, the colour changes induced by blending are equivalent to those induced by limb darkening, causing serious distortion in the observed colour curve. Therefore, to obtain useful information about the lens and source star from the colour curve of an event, it will be essential to correct for blending. We discuss various methods of blending correction.

Genome survey of pistachio (Pistacia vera L.) by next generation sequencing: Development of novel SSR markers and genetic diversity in Pistacia species.

PubMed

Ziya Motalebipour, Elmira; Kafkas, Salih; Khodaeiaminjan, Mortaza; Çoban, Nergiz; Gözel, Hatice

2016-12-07

Pistachio (Pistacia vera L.) is one of the most important nut crops in the world. There are about 11 wild species in the genus Pistacia, and they have importance as rootstock seed sources for cultivated P. vera and forest trees. Published information on the pistachio genome is limited. Therefore, a genome survey is necessary to obtain knowledge on the genome structure of pistachio by next generation sequencing. Simple sequence repeat (SSR) markers are useful tools for germplasm characterization, genetic diversity analysis, and genetic linkage mapping, and may help to elucidate genetic relationships among pistachio cultivars and species. To explore the genome structure of pistachio, a genome survey was performed using the Illumina platform at approximately 40× coverage depth in the P. vera cv. Siirt. The K-mer analysis indicated that pistachio has a genome that is about 600 Mb in size and is highly heterozygous. The assembly of 26.77 Gb Illumina data produced 27,069 scaffolds at N50 = 3.4 kb with a total of 513.5 Mb. A total of 59,280 SSR motifs were detected with a frequency of 8.67 kb. A total of 206 SSRs were used to characterize 24 P. vera cultivars and 20 wild Pistacia genotypes (four genotypes from each five wild Pistacia species) belonging to P. atlantica, P. integerrima, P. chinenesis, P. terebinthus, and P. lentiscus genotypes. Overall 135 SSR loci amplified in all 44 cultivars and genotypes, 41 were polymorphic in six Pistacia species. The novel SSR loci developed from cultivated pistachio were highly transferable to wild Pistacia species. The results from a genome survey of pistachio suggest that the genome size of pistachio is about 600 Mb with a high heterozygosity rate. This information will help to design whole genome sequencing strategies for pistachio. The newly developed novel polymorphic SSRs in this study may help germplasm characterization, genetic diversity, and genetic linkage mapping studies in the genus Pistacia.

The Next Generation Virgo Cluster Survey. XII. Stellar Populations and Kinematics of Compact, Low-mass Early-type Galaxies from Gemini GMOS-IFU Spectroscopy

NASA Astrophysics Data System (ADS)

Guérou, Adrien; Emsellem, Eric; McDermid, Richard M.; Côté, Patrick; Ferrarese, Laura; Blakeslee, John P.; Durrell, Patrick R.; MacArthur, Lauren A.; Peng, Eric W.; Cuillandre, Jean-Charles; Gwyn, Stephen

2015-05-01

We present Gemini Multi Object Spectrograph integral-field unit (GMOS-IFU) data of eight compact, low-mass early-type galaxies (ETGs) in the Virgo cluster. We analyze their stellar kinematics and stellar population and present two-dimensional maps of these properties covering the central 5″ × 7″ region. We find a large variety of kinematics, from nonrotating to highly rotating objects, often associated with underlying disky isophotes revealed by deep images from the Next Generation Virgo Cluster Survey. In half of our objects, we find a centrally concentrated younger and more metal-rich stellar population. We analyze the specific stellar angular momentum through the λR parameter and find six fast rotators and two slow rotators, one having a thin counterrotating disk. We compare the local galaxy density and stellar populations of our objects with those of 39 more extended low-mass Virgo ETGs from the SMAKCED survey and 260 massive (M > 1010 {{M}⊙ }) ETGs from the ATLAS3D sample. The compact low-mass ETGs in our sample are located in high-density regions, often close to a massive galaxy, and have, on average, older and more metal-rich stellar populations than less compact low-mass galaxies. We find that the stellar population parameters follow lines of constant velocity dispersion in the mass-size plane, smoothly extending the comparable trends found for massive ETGs. Our study supports a scenario where low-mass compact ETGs have experienced long-lived interactions with their environment, including ram-pressure stripping and gravitational tidal forces, that may be responsible for their compact nature.

The Laser Communications Relay and the Path to the Next Generation Near Earth Relay

NASA Technical Reports Server (NTRS)

Israel, David J.

2015-01-01

NASA Goddard Space Flight Center is currently developing the Laser Communications Relay Demonstration (LCRD) as a Path to the Next Generation Near Earth Space Communication Network. The current NASA Space Network or Tracking and Data Relay Satellite System is comprised of a constellation of Tracking and Data Relay Satellites (TDRS) in geosynchronous orbit and associated ground stations and operation centers. NASA is currently targeting a next generation of relay capability on orbit in the 2025 timeframe.

Computational Tools and Facilities for the Next-Generation Analysis and Design Environment

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler); Malone, John B. (Compiler)

1997-01-01

This document contains presentations from the joint UVA/NASA Workshop on Computational Tools and Facilities for the Next-Generation Analysis and Design Environment held at the Virginia Consortium of Engineering and Science Universities in Hampton, Virginia on September 17-18, 1996. The presentations focused on the computational tools and facilities for analysis and design of engineering systems, including, real-time simulations, immersive systems, collaborative engineering environment, Web-based tools and interactive media for technical training. Workshop attendees represented NASA, commercial software developers, the aerospace industry, government labs, and academia. The workshop objectives were to assess the level of maturity of a number of computational tools and facilities and their potential for application to the next-generation integrated design environment.

Genetic counselors’ (GC) knowledge, awareness, and understanding of clinical next-generation sequencing (NGS) genomic testing

PubMed Central

Boland, PM; Ruth, K; Matro, JM; Rainey, KL; Fang, CY; Wong, YN; Daly, MB; Hall, MJ

2014-01-01

Genomic tests are increasingly complex, less expensive, and more widely available with the advent of next-generation sequencing (NGS). We assessed knowledge and perceptions among genetic counselors pertaining to NGS genomic testing via an online survey. Associations between selected characteristics and perceptions were examined. Recent education on NGS testing was common, but practical experience limited. Perceived understanding of clinical NGS was modest, specifically concerning tumor testing. Greater perceived understanding of clinical NGS testing correlated with more time spent in cancer-related counseling, exposure to NGS testing, and NGS-focused education. Substantial disagreement about the role of counseling for tumor-based testing was seen. Finally, a majority of counselors agreed with the need for more education about clinical NGS testing, supporting this approach to optimizing implementation. PMID:25523111

Fabrication of optical microlenses by a new inkjet printing technique based on pyro-electrohydrodynamic (PEHD) effect

NASA Astrophysics Data System (ADS)

Coppola, S.; Vespini, V.; Grimaldi, I. A.; Loffredo, F.; Villani, F.; Miccio, L.; Grilli, S.; Ferraro, P.

2012-06-01

Here the pyroelectric functionality of a Lithium Niobate (LN) substrate is used for non-contact manipulation of liquids. In this work we introduced the use of a pyro-electrohydrodynamc (PEHD) dispenser for the manipulation of high viscous polymer materials leading to the fabrication of arrays of microlenses. The set-up used for the experiment is described and the fabricated microlenses are analyzed by means of the Digital Holography (DH) set-up in transmission mode and through profilometric analysis. PMMA based ink was employed for the realization of optical quality microsctructures whose geometrical properties and, hence, the focal lengths were controlled by modifying the printing configuration of the PEHD method. The profilometric results are in agreement with those calculated using the digital holography technique.

Generation After Next Propulsor Research: Robust Design for Embedded Engine Systems

NASA Technical Reports Server (NTRS)

Arend, David J.; Tillman, Gregory; O'Brien, Walter F.

2012-01-01

The National Aeronautics and Space Administration, United Technologies Research Center and Virginia Polytechnic and State University have contracted to pursue multi-disciplinary research into boundary layer ingesting (BLI) propulsors for generation after next environmentally responsible subsonic fixed wing aircraft. This Robust Design for Embedded Engine Systems project first conducted a high-level vehicle system study based on a large commercial transport class hybrid wing body aircraft, which determined that a 3 to 5 percent reduction in fuel burn could be achieved over a 7,500 nanometer mission. Both pylon-mounted baseline and BLI propulsion systems were based on a low-pressure-ratio fan (1.35) in an ultra-high-bypass ratio engine (16), consistent with the next generation of advanced commercial turbofans. An optimized, coupled BLI inlet and fan system was subsequently designed to achieve performance targets identified in the system study. The resulting system possesses an inlet with total pressure losses less than 0.5%, and a fan stage with an efficiency debit of less than 1.5 percent relative to the pylon-mounted, clean-inflow baseline. The subject research project has identified tools and methodologies necessary for the design of next-generation, highly-airframe-integrated propulsion systems. These tools will be validated in future large-scale testing of the BLI inlet / fan system in NASA's 8 foot x 6 foot transonic wind tunnel. In addition, fan unsteady response to screen-generated total pressure distortion is being characterized experimentally in a JT15D engine test rig. These data will document engine sensitivities to distortion magnitude and spatial distribution, providing early insight into key physical processes that will control BLI propulsor design.

Looking ahead to our next generation of nurse leaders: Generation X Nurse Managers.

PubMed

Keys, Yolanda

2014-01-01

The present inquiry identifies elements of professional success, and personal and professional fulfilment as defined by Generation X Nurse Managers. Although work concerning Nurse Manager preparation has been documented, there is a paucity of research specific to the generation of nurses next in line to assume leadership roles. For the purposes of this study, a qualitative approach was used to develop insight regarding Generation X Nurse Managers and their perspectives on professional success, personal and professional fulfilment, and organisational environments that are conducive to loyalty and long-term professional commitment. Findings from this study reinforced those identified in the original study in that inflexible organisational cultures, a lack of opportunities for upward mobility, the need to be available at all times, feeling stereotyped or undervalued can all be barriers to members of Generation X perceptions of professional success and professional and personal fulfilment. Study findings suggest that Generation X Nurse Managers would benefit from initiatives focused on better preparation for the Nurse Manager role, openness to innovative scheduling alternatives and tailored support and feedback. © 2014 John Wiley & Sons Ltd.

Next generation and biosimilar monoclonal antibodies

PubMed Central

2011-01-01

The Next Generation and Biosimilar Monoclonal Antibodies: Essential Considerations Towards Regulatory Acceptance in Europe workshop, organized by the European Centre of Regulatory Affairs Freiburg (EUCRAF), was held February 3–4, 2011 in Freiburg, Germany. The workshop attracted over 100 attendees from 15 countries, including regulators from 11 agencies, who interacted over the course of two days. The speakers presented their authoritative views on monoclonal antibodies (mAbs) as attractive targets for development, the experience to date with the regulatory process for biosimilar medicinal products, the European Medicines Agency draft guideline on biosimilar mAbs, as well as key elements in the development of mAbs. Participants engaged in many lively discussions, and much speculation on the nature of the quality, non-clinical and clinical requirements for authorization of biosimilar mAbs. PMID:21487235

Design of association studies with pooled or un-pooled next-generation sequencing data.

PubMed

Kim, Su Yeon; Li, Yingrui; Guo, Yiran; Li, Ruiqiang; Holmkvist, Johan; Hansen, Torben; Pedersen, Oluf; Wang, Jun; Nielsen, Rasmus

2010-07-01

Most common hereditary diseases in humans are complex and multifactorial. Large-scale genome-wide association studies based on SNP genotyping have only identified a small fraction of the heritable variation of these diseases. One explanation may be that many rare variants (a minor allele frequency, MAF <5%), which are not included in the common genotyping platforms, may contribute substantially to the genetic variation of these diseases. Next-generation sequencing, which would allow the analysis of rare variants, is now becoming so cheap that it provides a viable alternative to SNP genotyping. In this paper, we present cost-effective protocols for using next-generation sequencing in association mapping studies based on pooled and un-pooled samples, and identify optimal designs with respect to total number of individuals, number of individuals per pool, and the sequencing coverage. We perform a small empirical study to evaluate the pooling variance in a realistic setting where pooling is combined with exon-capturing. To test for associations, we develop a likelihood ratio statistic that accounts for the high error rate of next-generation sequencing data. We also perform extensive simulations to determine the power and accuracy of this method. Overall, our findings suggest that with a fixed cost, sequencing many individuals at a more shallow depth with larger pool size achieves higher power than sequencing a small number of individuals in higher depth with smaller pool size, even in the presence of high error rates. Our results provide guidelines for researchers who are developing association mapping studies based on next-generation sequencing. (c) 2010 Wiley-Liss, Inc.

Quality of Service for Real-Time Applications Over Next Generation Data Networks

NASA Technical Reports Server (NTRS)

Atiquzzaman, Mohammed; Jain, Raj

2001-01-01

This project, which started on January 1, 2000, was funded by the NASA Glenn Research Center for duration of one year. The deliverables of the project included the following tasks: (1) Study of QoS mapping between the edge and core networks envisioned in the Next Generation networks will provide us with the QoS guarantees that can be obtained from next generation networks; (2) Buffer management techniques to provide strict guarantees to real-time end-to-end applications through preferential treatment to packets belonging to real-time applications. In particular, use of ECN to help reduce the loss on high bandwidth-delay product satellite networks needs to be studied; (3) Effect of Prioritized Packet Discard to increase goodput of the network and reduce the buffering requirements in the ATM switches; (4) Provision of new IP circuit emulation services over Satellite IP backbones using MPLS will be studied; and (5) Determine the architecture and requirements for internetworking ATN and the Next Generation Internet for real-time applications. The project has been completed on time. All the objectives and deliverables of the project have been completed. Research results obtained from this project have been published in a number of papers in journals, conferences, and technical reports, included in this document.

Jet printing of convex and concave polymer micro-lenses.

PubMed

Blattmann, M; Ocker, M; Zappe, H; Seifert, A

2015-09-21

We describe a novel approach for fabricating customized convex as well as concave micro-lenses using substrates with sophisticated pinning architecture and utilizing a drop-on-demand jet printer. The polymeric lens material deposited on the wafer is cured by UV light irradiation yielding lenses with high quality surfaces. Surface shape and roughness of the cured polymer lenses are characterized by white light interferometry. Their optical quality is demonstrated by imaging an USAF1951 test chart. The evaluated modulation transfer function is compared to Zemax simulations as a benchmark for the fabricated lenses.

CRISPR-engineered genome editing for the next generation neurological disease modeling.

PubMed

Feng, Weijun; Liu, Hai-Kun; Kawauchi, Daisuke

2018-02-02

Neurological disorders often occur because of failure of proper brain development and/or appropriate maintenance of neuronal circuits. In order to understand roles of causative factors (e.g. genes, cell types) in disease development, generation of solid animal models has been one of straight-forward approaches. Recent next generation sequencing studies on human patient-derived clinical samples have identified various types of recurrent mutations in individual neurological diseases. While these discoveries have prompted us to evaluate impact of mutated genes on these neurological diseases, a feasible but flexible genome editing tool had remained to be developed. An advance of genome editing technology using the clustered regularly interspaced short palindromic repeats (CRISPR) with the CRISPR-associated protein (Cas) offers us a tremendous potential to create a variety of mutations in the cell, leading to "next generation" disease models carrying disease-associated mutations. We will here review recent progress of CRISPR-based brain disease modeling studies and discuss future requirement to tackle current difficulties in usage of these technologies. Copyright © 2017 Elsevier Inc. All rights reserved.

Review of the evolution of display technologies for next-generation aircraft

NASA Astrophysics Data System (ADS)

Tchon, Joseph L.; Barnidge, Tracy J.

2015-05-01

Advancements in electronic display technologies have provided many benefits for military avionics. The modernization of legacy tanker transport aircraft along with the development of next-generation platforms, such as the KC-46 aerial refueling tanker, offers a timeline of the evolution of avionics display approaches. The adaptation of advanced flight displays from the Boeing 787 for the KC-46 flight deck also provides examples of how avionics display solutions may be leveraged across commercial and military flight decks to realize greater situational awareness and improve overall mission effectiveness. This paper provides a review of the display technology advancements that have led to today's advanced avionics displays for the next-generation KC-46 tanker aircraft. In particular, progress in display operating modes, backlighting, packaging, and ruggedization will be discussed along with display certification considerations across military and civilian platforms.

The First Simultaneous Microlensing Observations by Two Space Telescopes: Spitzer and Swift Reveal a Brown Dwarf in Event OGLE-2015-BLG-1319

NASA Technical Reports Server (NTRS)

Shvartzvald, Y.; Li, Z.; Udalski, A.; Gould, A.; Sumi, T.; Street, R. A.; Calchi Novati, S.; Hundertmark, M.; Bozza, V.; Beichman, C.;

NextGEOSS: The Next Generation Data Hub For Earth Observations

NASA Astrophysics Data System (ADS)

Lilja Bye, Bente; De Lathouwer, Bart; Catarino, Nuno; Concalves, Pedro; Trijssenaar, Nicky; Grosso, Nuno; Meyer-Arnek, Julian; Goor, Erwin

2017-04-01

The Group on Earth observation embarked on the next 10 year phase with an ambition to streamline and further develop its achievements in building the Global Earth Observing System of Systems (GEOSS). The NextGEOSS project evolves the European vision of GEOSS data exploitation for innovation and business, relying on the three main pillars of engaging communities, delivering technological developments and advocating the use of GEOSS, in order to support the creation and deployment of Earth observation based innovative research activities and commercial services. In this presentation we will present the NextGEOSS concept, a concept that revolves around providing the data and resources to the users communities, together with Cloud resources, seamlessly connected to provide an integrated ecosystem for supporting applications. A central component of NextGEOSS is the strong emphasis put on engaging the communities of providers and users, and bridging the space in between.

The NASA Education Enterprise: Inspiring the Next Generation of Explorers

NASA Technical Reports Server (NTRS)

2003-01-01

On April 12, 2002, NASA Administrator Sean O Keefe opened a new window to the future of space exploration with these words in his Pioneering the Future address. Thus began the conceptual framework for structuring the new Education Enterprise. The Agency s mission is to understand and protect our home planet; to explore the universe in search for life; and to inspire the next generation of explorers as only NASA can. In adopting this mission, education became a core element and is now a vital part of every major NASA research and development mission. NASA s call to inspire the next generation of explorers is now resounding throughout the NASA community and schools of all levels all around the country. The goal is to capture student interest, nurture their natural curiosities, and intrigue their minds with new and exciting scientific research; as well as to provide educators with the creative tools they need to improve America s scientific literacy. The future of NASA begins with America s youngest scholars. According to Administrator O Keefe s address, if NASA does not motivate the youngest generation now, there is little prospect this generation will choose to pursue scientific disciplines later. Since embracing Administrator O Keefe s educational mandate over a year ago, NASA has been fully devoted to broadening its roadmap to motivation. The efforts have generated a whole new showcase of thoughtprovoking and fun learning opportunities, through printed material, Web sites and Webcasts, robotics, rocketry, aerospace design contests, and various other resources as only NASA can.

Next Generation Sequencing at the University of Chicago Genomics Core

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faber, Pieter

2013-04-24

The University of Chicago Genomics Core provides University of Chicago investigators (and external clients) access to State-of-the-Art genomics capabilities: next generation sequencing, Sanger sequencing / genotyping and micro-arrays (gene expression, genotyping, and methylation). The current presentation will highlight our capabilities in the area of ultra-high throughput sequencing analysis.

The "Next Generation Science Standards": A Focus on Physical Science

ERIC Educational Resources Information Center

Krajcik, Joe

2013-01-01

What should all students know about the physical sciences? Why should all students have a basic understanding of these ideas? An amazing number of new scientific breakthroughs have occurred in the last 20 years that impact daily lives. This article focuses on the "Next Generation Science Standards" (NGSS) disciplinary core ideas in…

The Next Generation of Science Standards: Implications for Biology Education

ERIC Educational Resources Information Center

Bybee, Rodger W.

2012-01-01

The release of A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (NRC, 2012) provides the basis for the next generation of science standards. This article first describes that foundation for the life sciences; it then presents a draft standard for natural selection and evolution. Finally, there is a…

Process Improvement for Next Generation Space Flight Vehicles: MSFC Lessons Learned

NASA Technical Reports Server (NTRS)

Housch, Helen

2008-01-01

This viewgraph presentation reviews the lessons learned from process improvement for Next Generation Space Flight Vehicles. The contents include: 1) Organizational profile; 2) Process Improvement History; 3) Appraisal Preparation; 4) The Appraisal Experience; 5) Useful Tools; and 6) Is CMMI working?

Towards the next generation of simplified Dark Matter models

NASA Astrophysics Data System (ADS)

Albert, Andreas; Bauer, Martin; Brooke, Jim; Buchmueller, Oliver; Cerdeño, David G.; Citron, Matthew; Davies, Gavin; de Cosa, Annapaola; De Roeck, Albert; De Simone, Andrea; Du Pree, Tristan; Flaecher, Henning; Fairbairn, Malcolm; Ellis, John; Grohsjean, Alexander; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Khoze, Valentin V.; Landsberg, Greg; McCabe, Christopher; Penning, Bjoern; Sanz, Veronica; Schwanenberger, Christian; Scott, Pat; Wardle, Nicholas

2017-06-01

This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete examples, we show how existing SDMM can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we review important aspects of supersymmetric models for DM and use them to propose how to develop more complete SDMMs. This White Paper is a summary of the brainstorming meeting "Next generation of simplified Dark Matter models" that took place at Imperial College, London on May 6, 2016, and corresponding follow-up studies on selected subjects.

Gravitational microlensing by double stars and planetary systems

NASA Technical Reports Server (NTRS)

Mao, Shunde; Paczynski, Bohdan

1991-01-01

Almost all stars are in binary systems. When the separation between the two components is comparable to the Einstein ring radius corresponding to the combined mass of the binary acting as a gravitational lens, then an extra pair of images can be created, and the light curve of a lensed source becomes complicated. It is estimated that about 10 percent of all lensing episodes of the Galactic bulge stars will strongly display the binary nature of the lens. The effect is strong even if the companion is a planet. A massive search for microlensing of the Galactic bulge stars may lead to a discovery of the first extrasolar planetary systems.

Bringing Next-Generation Sequencing into the Classroom through a Comparison of Molecular Biology Techniques

ERIC Educational Resources Information Center

Bowling, Bethany; Zimmer, Erin; Pyatt, Robert E.

2014-01-01

Although the development of next-generation (NextGen) sequencing technologies has revolutionized genomic research and medicine, the incorporation of these topics into the classroom is challenging, given an implied high degree of technical complexity. We developed an easy-to-implement, interactive classroom activity investigating the similarities…

Engineered CRISPR Systems for Next Generation Gene Therapies.

PubMed

Pineda, Michael; Moghadam, Farzaneh; Ebrahimkhani, Mo R; Kiani, Samira

2017-09-15

An ideal in vivo gene therapy platform provides safe, reprogrammable, and precise strategies which modulate cell and tissue gene regulatory networks with a high temporal and spatial resolution. Clustered regularly interspaced short palindromic repeats (CRISPR), a bacterial adoptive immune system, and its CRISPR-associated protein 9 (Cas9), have gained attention for the ability to target and modify DNA sequences on demand with unprecedented flexibility and precision. The precision and programmability of Cas9 is derived from its complexation with a guide-RNA (gRNA) that is complementary to a desired genomic sequence. CRISPR systems open-up widespread applications including genetic disease modeling, functional screens, and synthetic gene regulation. The plausibility of in vivo genetic engineering using CRISPR has garnered significant traction as a next generation in vivo therapeutic. However, there are hurdles that need to be addressed before CRISPR-based strategies are fully implemented. Some key issues center on the controllability of the CRISPR platform, including minimizing genomic-off target effects and maximizing in vivo gene editing efficiency, in vivo cellular delivery, and spatial-temporal regulation. The modifiable components of CRISPR systems: Cas9 protein, gRNA, delivery platform, and the form of CRISPR system delivered (DNA, RNA, or ribonucleoprotein) have recently been engineered independently to design a better genome engineering toolbox. This review focuses on evaluating CRISPR potential as a next generation in vivo gene therapy platform and discusses bioengineering advancements that can address challenges associated with clinical translation of this emerging technology.

Direct target NOTES: prospective applications for next generation robotic platforms.

PubMed

Atallah, S; Hodges, A; Larach, S W

2018-05-01

A new era in surgical robotics has centered on alternative access to anatomic targets and next generation designs include flexible, single-port systems which follow circuitous rather than straight pathways. Such systems maintain a small footprint and could be utilized for specialized operations based on direct organ target natural orifice transluminal endoscopic surgery (NOTES), of which transanal total mesorectal excision (taTME) is an important derivative. During two sessions, four direct target NOTES operations were conducted on a cadaveric model using a flexible robotic system to demonstrate proof-of-concept of the application of a next generation robotic system to specific types of NOTES operations, all of which required removal of a direct target organ through natural orifice access. These four operations were (a) robotic taTME, (b) robotic transvaginal hysterectomy in conjunction with (c) robotic transvaginal salpingo-oophorectomy, and in an ex vivo model, (d) trans-cecal appendectomy. Feasibility was demonstrated in all cases using the Flex ® Robotic System with Colorectal Drive. During taTME, the platform excursion was 17 cm along a non-linear path; operative time was 57 min for the transanal portion of the dissection. Robotic transvaginal hysterectomy was successfully completed in 78 min with transvaginal extraction of the uterus, although laparoscopic assistance was required. Robotic transvaginal unilateral salpingo-oophorectomy with transvaginal extraction of the ovary and fallopian tube was performed without laparoscopic assistance in 13.5 min. In an ex vivo model, a robotic trans-cecal appendectomy was also successfully performed for the purpose of demonstrating proof-of-concept only; this was completed in 24 min. A flexible robotic system has the potential to access anatomy along circuitous paths, making it a suitable platform for direct target NOTES. The conceptual operations posed could be considered suitable for next generation robotics once

The Next Generation Science Standards: A Focus on Physical Science

ERIC Educational Resources Information Center

Krajcik, Joe

2013-01-01

This article describes ways to adapt U.S. science curriculum to the U.S. National Research Council (NRC) "Framework for K-12 Science Education" and "Next Generation of Science Standards" (NGSS), noting their focus on teaching the physical sciences. The overall goal of the Framework and NGSS is to help all learners develop the…

NOAA's weather forecasts go hyper-local with next-generation weather

Science.gov Websites

model NOAA HOME WEATHER OCEANS FISHERIES CHARTING SATELLITES CLIMATE RESEARCH COASTS CAREERS with next-generation weather model New model will help forecasters predict a storm's path, timing and intensity better than ever September 30, 2014 This is a comparison of two weather forecast models looking

Research and Development Supporting a Next Generation Germanium Double Beta Decay Experiment

NASA Astrophysics Data System (ADS)

Rielage, Keith; Elliott, Steve; Chu, Pinghan; Goett, Johnny; Massarczyk, Ralph; Xu, Wenqin

2015-10-01

To improve the search for neutrinoless double beta decay, the next-generation experiments will increase in source mass and continue to reduce backgrounds in the region of interest. A promising technology for the next generation experiment is large arrays of Germanium p-type point contact detectors enriched in 76-Ge. The experience, expertise and lessons learned from the MAJORANA DEMONSTRATOR and GERDA experiments naturally lead to a number of research and development activities that will be useful in guiding a future experiment utilizing Germanium. We will discuss some R&D activities including a hybrid cryostat design, background reduction in cabling, connectors and electronics, and modifications to reduce assembly time. We acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program.

Genetic counselors' (GC) knowledge, awareness, understanding of clinical next-generation sequencing (NGS) genomic testing.

PubMed

Boland, P M; Ruth, K; Matro, J M; Rainey, K L; Fang, C Y; Wong, Y N; Daly, M B; Hall, M J

2015-12-01

Genomic tests are increasingly complex, less expensive, and more widely available with the advent of next-generation sequencing (NGS). We assessed knowledge and perceptions among genetic counselors pertaining to NGS genomic testing via an online survey. Associations between selected characteristics and perceptions were examined. Recent education on NGS testing was common, but practical experience limited. Perceived understanding of clinical NGS was modest, specifically concerning tumor testing. Greater perceived understanding of clinical NGS testing correlated with more time spent in cancer-related counseling, exposure to NGS testing, and NGS-focused education. Substantial disagreement about the role of counseling for tumor-based testing was seen. Finally, a majority of counselors agreed with the need for more education about clinical NGS testing, supporting this approach to optimizing implementation. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Next Generation Workload Management and Analysis System for Big Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

De, Kaushik

We report on the activities and accomplishments of a four-year project (a three-year grant followed by a one-year no cost extension) to develop a next generation workload management system for Big Data. The new system is based on the highly successful PanDA software developed for High Energy Physics (HEP) in 2005. PanDA is used by the ATLAS experiment at the Large Hadron Collider (LHC), and the AMS experiment at the space station. The program of work described here was carried out by two teams of developers working collaboratively at Brookhaven National Laboratory (BNL) and the University of Texas at Arlingtonmore » (UTA). These teams worked closely with the original PanDA team – for the sake of clarity the work of the next generation team will be referred to as the BigPanDA project. Their work has led to the adoption of BigPanDA by the COMPASS experiment at CERN, and many other experiments and science projects worldwide.« less

Next-generation sequencing for targeted discovery of rare mutations in rice

USDA-ARS?s Scientific Manuscript database

Advances in DNA sequencing (i.e., next-generation sequencing, NGS) have greatly increased the power and efficiency of detecting rare mutations in large mutant populations. Targeting Induced Local Lesions in Genomes (TILLING) is a reverse genetics approach for identifying gene mutations resulting fro...

ESUPPO: Next Generation

DTIC Science & Technology

2017-12-01

sessions were correlated quantitatively by the web-based survey , identifying the need to update eSUPPO with specific icons such as Innovation...focus groups and surveys , assesses how well the mobile app meets the needs of the Supply Corps community. The analysis begins by understanding the...the app. After a complete analysis of eSUPPO’s current “As-Is” processes, the study takes the information gathered from both the survey and focus

Controls concepts for next generation reuseable rocket engines

NASA Technical Reports Server (NTRS)

Lorenzo, Carl F.; Merrill, Walter C.; Musgrave, Jefferey L.; Ray, Asok

1995-01-01

Three primary issues will drive the design and control used in next generation reuseable rocket engines. In addition to steady-state and dynamic performance, the requirements for increased durability, reliability and operability (with faults) will dictate which new controls and design technologies and features will be brought to bear. An array of concepts which have been brought forward will be tested against the measures of cost and benefit as reflected in the above 'ilities'. This paper examines some of the new concepts and looks for metrics to judge their value.

NGSS and the Next Generation of Science Teachers

NASA Astrophysics Data System (ADS)

Bybee, Rodger W.

2014-03-01

This article centers on the Next Generation Science Standards (NGSS) and their implications for teacher development, particularly at the undergraduate level. After an introduction to NGSS and the influence of standards in the educational system, the article addresses specific educational shifts—interconnecting science and engineering practices, disciplinary core ideas, crosscutting concepts; recognizing learning progressions; including engineering; addressing the nature of science, coordinating with Common Core State Standards. The article continues with a general discussion of reforming teacher education programs and a concluding discussion of basic competencies and personal qualities of effective science teachers.

Next Generation Lithium-Ion Cell For Satellite Applications

NASA Astrophysics Data System (ADS)

Inoue, Takefumi; Segawa, Masazumi; Yoshida, Hiroaki; Takeda, Koichi

2011-10-01

GS Yuasa Technology has standard line up cells for satellite applications since 1999. The design of these cells is not changed and their production will continue. GS Yuasa is now developing higher performance Next Generation Lithium-ion cells. These cells have an improved positive material, negative material, electrolyte, and separator and have demonstrated excellent capacity retention with very low DC resistance growth during life testing. The new cell has approximately 40% more EOL energy (Wh/kg), and slightly lighter weight while using the same size components as our existing products.

Airframe Technology Development for Next Generation Launch Vehicles

NASA Technical Reports Server (NTRS)

Glass, David E.

2004-01-01

The Airframe subproject within NASA's Next Generation Launch Technology (NGLT) program has the responsibility to develop airframe technology for both rocket and airbreathing vehicles for access to space. The Airframe sub-project pushes the state-of-the-art in airframe technology for low-cost, reliable, and safe space transportation. Both low and medium technology readiness level (TRL) activities are being pursued. The key technical areas being addressed include design and integration, hot and integrated structures, cryogenic tanks, and thermal protection systems. Each of the technologies in these areas are discussed in this paper.

Semantic e-Learning: Next Generation of e-Learning?

NASA Astrophysics Data System (ADS)

Konstantinos, Markellos; Penelope, Markellou; Giannis, Koutsonikos; Aglaia, Liopa-Tsakalidi

Semantic e-learning aspires to be the next generation of e-learning, since the understanding of learning materials and knowledge semantics allows their advanced representation, manipulation, sharing, exchange and reuse and ultimately promote efficient online experiences for users. In this context, the paper firstly explores some fundamental Semantic Web technologies and then discusses current and potential applications of these technologies in e-learning domain, namely, Semantic portals, Semantic search, personalization, recommendation systems, social software and Web 2.0 tools. Finally, it highlights future research directions and open issues of the field.

Controls concepts for next generation reuseable rocket engines

NASA Astrophysics Data System (ADS)

Lorenzo, Carl F.; Merrill, Walter C.; Musgrave, Jefferey L.; Ray, Asok

1995-04-01

Three primary issues will drive the design and control used in next generation reuseable rocket engines. In addition to steady-state and dynamic performance, the requirements for increased durability, reliability and operability (with faults) will dictate which new controls and design technologies and features will be brought to bear. An array of concepts which have been brought forward will be tested against the measures of cost and benefit as reflected in the above 'ilities'. This paper examines some of the new concepts and looks for metrics to judge their value.

Toxicogenomics and Cancer Susceptibility: Advances with Next-Generation Sequencing

PubMed Central

Ning, Baitang; Su, Zhenqiang; Mei, Nan; Hong, Huixiao; Deng, Helen; Shi, Leming; Fuscoe, James C.; Tolleson, William H.

2017-01-01

The aim of this review is to comprehensively summarize the recent achievements in the field of toxicogenomics and cancer research regarding genetic-environmental interactions in carcinogenesis and detection of genetic aberrations in cancer genomes by next-generation sequencing technology. Cancer is primarily a genetic disease in which genetic factors and environmental stimuli interact to cause genetic and epigenetic aberrations in human cells. Mutations in the germline act as either high-penetrance alleles that strongly increase the risk of cancer development, or as low-penetrance alleles that mildly change an individual’s susceptibility to cancer. Somatic mutations, resulting from either DNA damage induced by exposure to environmental mutagens or from spontaneous errors in DNA replication or repair are involved in the development or progression of the cancer. Induced or spontaneous changes in the epigenome may also drive carcinogenesis. Advances in next-generation sequencing technology provide us opportunities to accurately, economically, and rapidly identify genetic variants, somatic mutations, gene expression profiles, and epigenetic alterations with single-base resolution. Whole genome sequencing, whole exome sequencing, and RNA sequencing of paired cancer and adjacent normal tissue present a comprehensive picture of the cancer genome. These new findings should benefit public health by providing insights in understanding cancer biology, and in improving cancer diagnosis and therapy. PMID:24875441

Diagnosis of local hepatic tuberculosis through next-generation sequencing: Smarter, faster and better.

PubMed

Ai, Jing-Wen; Li, Yang; Cheng, Qi; Cui, Peng; Wu, Hong-Long; Xu, Bin; Zhang, Wen-Hong

2018-06-01

A 45-year-old man who complained of continuous fever and multiple hepatic masses was admitted to our hospital. Repeated MRI manifestations were similar while each radiological report suggested contradictory diagnosis pointing to infections or malignances respectively. Pathologic examination of the liver tissue showed no direct evidence of either infections or tumor. We performed next-generation sequencing on the liver tissue and peripheral blood to further investigate the possible etiology. High throughput sequencing was performed on the liver lesion tissues using BGISEQ-100 platform, and data was mapped to the Microbial Genome Databases after filtering low quality data and human reads. We identified a total of 299 sequencing reads of Mycobacterium tuberculosis (M. tuberculosis) complex sequences from the liver tissue, including 8, 229 of 4,424,435 of the M. tuberculosis nucleotide sequences, and Mycobacterium africanum, Mycobacterium bovis, and Mycobacterium canettii were also detected due to the 99.9% identical rate among these strains. No specific Mycobacterial tuberculosis nucleotide sequence was detected in the sample of peripheral blood. Patient's symptom quickly recovered after anti-tuberculosis treatment and repeated Ziehl-Neelsen staining of the liver tissue finally identified small numbers of positive bacillus. The diagnosis of this patient was difficult to establish before the next-generation sequencing because of contradictive radiological results and negative pathological findings. More sensitive diagnostic methods are urgently needed. This is the first case reporting hepatic tuberculosis confirmed by the next-generation sequencing, and marks the promising potential of the application of the next-generation sequencing in the diagnosis of hepatic lesions with unknown etiology. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Statistical improvement in detection level of gravitational microlensing events from their light curves

NASA Astrophysics Data System (ADS)

Ibrahim, Ichsan; Malasan, Hakim L.; Kunjaya, Chatief; Timur Jaelani, Anton; Puannandra Putri, Gerhana; Djamal, Mitra

2018-04-01

In astronomy, the brightness of a source is typically expressed in terms of magnitude. Conventionally, the magnitude is defined by the logarithm of received flux. This relationship is known as the Pogson formula. For received flux with a small signal to noise ratio (S/N), however, the formula gives a large magnitude error. We investigate whether the use of Inverse Hyperbolic Sine function (hereafter referred to as the Asinh magnitude) in the modified formulae could allow for an alternative calculation of magnitudes for small S/N flux, and whether the new approach is better for representing the brightness of that region. We study the possibility of increasing the detection level of gravitational microlensing using 40 selected microlensing light curves from the 2013 and 2014 seasons and by using the Asinh magnitude. Photometric data of the selected events are obtained from the Optical Gravitational Lensing Experiment (OGLE). We found that utilization of the Asinh magnitude makes the events brighter compared to using the logarithmic magnitude, with an average of about 3.42 × 10‑2 magnitude and an average in the difference of error between the logarithmic and the Asinh magnitude of about 2.21 × 10‑2 magnitude. The microlensing events OB140847 and OB140885 are found to have the largest difference values among the selected events. Using a Gaussian fit to find the peak for OB140847 and OB140885, we conclude statistically that the Asinh magnitude gives better mean squared values of the regression and narrower residual histograms than the Pogson magnitude. Based on these results, we also attempt to propose a limit in magnitude value for which use of the Asinh magnitude is optimal with small S/N data.

Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft)

EPA Science Inventory

Next Generation of Risk Assessment (External Review Draft)" vspace = "5" hspace="5" align="right" border="1" /> EPA is releasing a draft report "Next Generation Risk Assessment: I...

[Application of targeted capture technology and next generation sequencing in molecular diagnosis of inherited myopathy].

PubMed

Fu, Xiaona; Liu, Aijie; Yang, Haipo; Wei, Cuijie; Ding, Juan; Wang, Shuang; Wang, Jingmin; Yuan, Yun; Jiang, Yuwu; Xiong, Hui

2015-10-01

To elucidate the usefulness of next generation sequencing for diagnosis of inherited myopathy, and to analyze the relevance between clinical phenotype and genotype in inherited myopathy. Related genes were selected for SureSelect target enrichment system kit (Panel Version 1 and Panel Version 2). A total of 134 patients who were diagnosed as inherited myopathy clinically underwent next generation sequencing in Department of Pediatrics, Peking University First Hospital from January 2013 to June 2014. Clinical information and gene detection result of the patients were collected and analyzed. Seventy-seven of 134 patients (89 males and 45 females, visiting ages from 6-month-old to 26-year-old, average visiting age was 6 years and 1 month) underwent next generation sequencing by Panel Version 1 in 2013, and 57 patients underwent next generation sequencing by Panel Version 2 in 2014. The gene detection revealed that 74 patients had pathogenic gene mutations, and the positive rate of genetic diagnosis was 55.22%. One patient was diagnosed as metabolic myopathy. Five patients were diagnosed as congenital myopathy; 68 were diagnosed as muscular dystrophy, including 22 with congenital muscular dystrophy 1A (MDC1A), 11 with Ullrich congenital muscular dystrophy (UCMD), 6 with Bethlem myopathy (BM), 12 with Duchenne muscular dystrophy (DMD) caused by point mutations in DMD gene, 5 with LMNA-related congenital muscular dystrophy (L-CMD), 1 with Emery-Dreifuss muscular dystrophy (EDMD), 7 with alpha-dystroglycanopathy (α-DG) patients, and 4 with limb-girdle muscular dystrophy (LGMD) patients. Next generation sequencing plays an important role in diagnosis of inherited myopathy. Clinical and biological information analysis was essential for screening pathogenic gene of inherited myopathy.

Evaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data

NASA Astrophysics Data System (ADS)

Sandmann, Sarah; de Graaf, Aniek O.; Karimi, Mohsen; van der Reijden, Bert A.; Hellström-Lindberg, Eva; Jansen, Joop H.; Dugas, Martin

2017-02-01

Valid variant calling results are crucial for the use of next-generation sequencing in clinical routine. However, there are numerous variant calling tools that usually differ in algorithms, filtering strategies, recommendations and thus, also in the output. We evaluated eight open-source tools regarding their ability to call single nucleotide variants and short indels with allelic frequencies as low as 1% in non-matched next-generation sequencing data: GATK HaplotypeCaller, Platypus, VarScan, LoFreq, FreeBayes, SNVer, SAMtools and VarDict. We analysed two real datasets from patients with myelodysplastic syndrome, covering 54 Illumina HiSeq samples and 111 Illumina NextSeq samples. Mutations were validated by re-sequencing on the same platform, on a different platform and expert based review. In addition we considered two simulated datasets with varying coverage and error profiles, covering 50 samples each. In all cases an identical target region consisting of 19 genes (42,322 bp) was analysed. Altogether, no tool succeeded in calling all mutations. High sensitivity was always accompanied by low precision. Influence of varying coverages- and background noise on variant calling was generally low. Taking everything into account, VarDict performed best. However, our results indicate that there is a need to improve reproducibility of the results in the context of multithreading.

Next generation: In-space transportation system(s)

NASA Technical Reports Server (NTRS)

Huffaker, Fredrick; Redus, Jerry; Kelley, David L.

1991-01-01

The development of the next generation In-Space Transportation System presents a unique challenge to the design of a propulsion system for the Space Exploration Initiative (SEI). Never before have the requirements for long-life, multiple mission use, space basing, high reliability, man-rating, and minimum maintenance come together with performance in one system that must protect the lives of space travelers, support the mission logistics needs, and do so at an acceptable cost. The challenge that is presented is to quantify the bounds of these requirements. The issue is one of degree. The length of acceptable life in space, the time it takes for reuse to pay off, and the degree to which space basing is practical (full, partial, or expended) are the issues that determine the reusable bounds of a design and include dependability, contingency capabilities, resilency, and minimum dependence on a maintenance node in preparation for and during a mission. Missions to planet earth, other non-NASA missions, and planetary missions will provide important but less demanding requirements for the transportation systems of the future. The mission proposed for the SEI require a family of transportation vehicles to meet the requirements for establishing a permanent human presence on the Moon and eventually on Mars. Specialized vehicles are needed to accomplish the different phases of each mission. These large scale missions require assembly in space and will provide the greatest usage of the planned integrated transportation system. The current approach to defining the In-Space Transportation System for the SEI Moon missions with later Mars mission applications is presented. Several system development options, propulsion concepts, current/proposed activities are reviewed, and key propulsion design criteria, issues, and technology challenges for the next generation In-Space Transportation System(s) are outlined.

Microlensing optical depth towards the Galactic Bulge using bright sources from OGLE-II

NASA Astrophysics Data System (ADS)

Sumi, T.; Woźniak, P.; Udalski, A.; Szymański, M.; Kubiak, M.; Pietrzyński, G.; Soszyński, I.; Zebruń, K.; Szewczyk, O.; Wyrzykowski, L.

2004-12-01

We present a measurement of the microlensing optical depth towards the Galactic Bulge by using bright stars as sources from the central 20 OGLE-II Galactic bulge fields covering a range of 0o microlensing candidates on source stars in an Extended Red Clump Giant (RCG) Region in the Colour Magnitude Diagram, where an extinction corrected I-band magnitude is brighter than about 15.5 mag. We find that a half of their source stars which are actually lensed are fainter blended stars. By using the 32 candidates whose actually lensed source stars are still in Extended RCG Region, we estimate the preliminary optical depth τ ˜ 2± 0.4 × 10-6 at (l,b)=(1.16, -2.75) for events with timescales 1< tE <200 days. This value is smaller than previous results with all sources but consistent with previous results with RCG sources and recent theoretical predictions.

TIME DELAY AND ACCRETION DISK SIZE MEASUREMENTS IN THE LENSED QUASAR SBS 0909+532 FROM MULTIWAVELENGTH MICROLENSING ANALYSIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hainline, Laura J.; Morgan, Christopher W.; MacLeod, Chelsea L.

2013-09-01

We present three complete seasons and two half-seasons of Sloan Digital Sky Survey (SDSS) r-band photometry of the gravitationally lensed quasar SBS 0909+532 from the U.S. Naval Observatory, as well as two seasons each of SDSS g-band and r-band monitoring from the Liverpool Robotic Telescope. Using Monte Carlo simulations to simultaneously measure the system's time delay and model the r-band microlensing variability, we confirm and significantly refine the precision of the system's time delay to {Delta}t{sub AB} = 50{sub -4}{sup +2} days, where the stated uncertainties represent the bounds of the formal 1{sigma} confidence interval. There may be a conflictmore » between the time delay measurement and a lens consisting of a single galaxy. While models based on the Hubble Space Telescope astrometry and a relatively compact stellar distribution can reproduce the observed delay, the models have somewhat less dark matter than we would typically expect. We also carry out a joint analysis of the microlensing variability in the r and g bands to constrain the size of the quasar's continuum source at these wavelengths, obtaining log {l_brace}(r{sub s,r}/cm)[cos i/0.5]{sup 1/2}{r_brace} = 15.3 {+-} 0.3 and log {l_brace}(r{sub s,g}/cm)[cos i/0.5]{sup 1/2}{r_brace} = 14.8 {+-} 0.9, respectively. Our current results do not formally constrain the temperature profile of the accretion disk but are consistent with the expectations of standard thin disk theory.« less

Molecular Characterization of Transgene Integration by Next-Generation Sequencing in Transgenic Cattle

PubMed Central

Zhang, Ran; Yin, Yinliang; Zhang, Yujun; Li, Kexin; Zhu, Hongxia; Gong, Qin; Wang, Jianwu; Hu, Xiaoxiang; Li, Ning

2012-01-01

As the number of transgenic livestock increases, reliable detection and molecular characterization of transgene integration sites and copy number are crucial not only for interpreting the relationship between the integration site and the specific phenotype but also for commercial and economic demands. However, the ability of conventional PCR techniques to detect incomplete and multiple integration events is limited, making it technically challenging to characterize transgenes. Next-generation sequencing has enabled cost-effective, routine and widespread high-throughput genomic analysis. Here, we demonstrate the use of next-generation sequencing to extensively characterize cattle harboring a 150-kb human lactoferrin transgene that was initially analyzed by chromosome walking without success. Using this approach, the sites upstream and downstream of the target gene integration site in the host genome were identified at the single nucleotide level. The sequencing result was verified by event-specific PCR for the integration sites and FISH for the chromosomal location. Sequencing depth analysis revealed that multiple copies of the incomplete target gene and the vector backbone were present in the host genome. Upon integration, complex recombination was also observed between the target gene and the vector backbone. These findings indicate that next-generation sequencing is a reliable and accurate approach for the molecular characterization of the transgene sequence, integration sites and copy number in transgenic species. PMID:23185606

Copy number variation of individual cattle genomes using next-generation sequencing

USDA-ARS?s Scientific Manuscript database

Copy number variations (CNVs) affect a wide range of phenotypic traits; however, CNVs in or near segmental duplication regions are often intractable. Using a read depth approach based on next-generation sequencing, we examined genome-wide copy number differences among five taurine (three Angus, one ...

The "Next Generation Science Standards" and the Earth and Space Sciences

ERIC Educational Resources Information Center

Wysession, Michael E.

2013-01-01

The "Next Generation Science Standards" ("NGSS"), due to be released this spring, represents a revolutionary step toward establishing modern, national K-12 science education standards. Based on the recommendations of the National Research Council's "A Framework for K-12 Science Education: Practices, Crosscutting…

Sibling Communication in "Star Trek: The Next Generation": Conflicts between Brothers.

ERIC Educational Resources Information Center

Fuss-Reineck, Marilyn

"Star Trek: The Next Generation" depicts sibling relationships between Data and Lore (android), Worf and Kurn (Klingon) and Jean-Luc and Robert (human) that illustrate conflictual communication and suggest teaching applications. The most disturbing empirical communication research on conflict between brothers reports that male sibling…

Using next generation sequencing for multiplexed trait-linked markers in wheat

USDA-ARS?s Scientific Manuscript database

With the advent of next generation sequencing (NGS) technologies, single nucleotide polymorphisms (SNPs) have become the major type of marker for genotyping in many crops. However, the availability of SNP markers for important traits of bread wheat (Triticum aestivum L.) that can be effectively used...

2016 ASMS Workshop Review: Next Generation LC/MS: Critical Insights and Future Perspectives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Hongying; Makarov, Alexander; Smith, Richard D.

The pilot workshop on BNext Generation LC/MS: Critical Insights and Future Perspectives was held on the evening of June 6, 2016 at the 64th ASMS Conference on Mass Spectrometry and Allied Topics held in San Antonio, TX. The workshop, chaired by Hongying Gao (Pfizer), consisted of stimulating talks from distinguished speakers and open discussion among the audience and invited presenters.The objectives of this workshop were to better understand the advances and limitations of current technologies; to exchange perspectives on the next generation LC/MS; and to discuss/debate the features of next generation LC/MS focusing on the following three questions: (1) Whatmore » would the next generation LC/MS look like? (2) How would it change the way we do analysis? and (3) What fundamental issues need to be resolved? A real-world case in the biopharmaceutical industry was presented by Hongying Gao on the needs by industry for LC/MS innovation and technology advancements. The primary invited speakers were Alexander Makarov (Thermo Fisher Scientific) and Richard (Dick) Smith (Pacific Northwest National Laboratory). The open discussions started with Q&A and comments for Alexander Makarov and Dick Smith, followed by insights and perspectives from members of the audience and other invited presenters who shared their thoughts addressing the above questions.« less

Next Generation Science Partnerships

NASA Astrophysics Data System (ADS)

Magnusson, J.

2016-02-01

I will provide an overview of the Next Generation Science Standards (NGSS) and demonstrate how scientists and educators can use these standards to strengthen and enhance their collaborations. The NGSS are rich in content and practice and provide all students with an internationally-benchmarked science education. Using these state-led standards to guide outreach efforts can help develop and sustain effective and mutually beneficial teacher-researcher partnerships. Aligning outreach with the three dimensions of the standards can help make research relevant for target audiences by intentionally addressing the science practices, cross-cutting concepts, and disciplinary core ideas of the K-12 science curriculum that drives instruction and assessment. Collaborations between researchers and educators that are based on this science framework are more sustainable because they address the needs of both scientists and educators. Educators are better able to utilize science content that aligns with their curriculum. Scientists who learn about the NGSS can better understand the frameworks under which educators work, which can lead to more extensive and focused outreach with teachers as partners. Based on this model, the International Ocean Discovery Program (IODP) develops its education materials in conjunction with scientists and educators to produce accurate, standards-aligned activities and curriculum-based interactions with researchers. I will highlight examples of IODP's current, successful teacher-researcher collaborations that are intentionally aligned with the NGSS.

The Next Generation Virgo Cluster Survey (NGVS). XXV. Fiducial Panchromatic Colors of Virgo Core Globular Clusters and Their Comparison to Model Predictions

NASA Astrophysics Data System (ADS)

Powalka, Mathieu; Lançon, Ariane; Puzia, Thomas H.; Peng, Eric W.; Liu, Chengze; Muñoz, Roberto P.; Blakeslee, John P.; Côté, Patrick; Ferrarese, Laura; Roediger, Joel; Sánchez-Janssen, Rúben; Zhang, Hongxin; Durrell, Patrick R.; Cuillandre, Jean-Charles; Duc, Pierre-Alain; Guhathakurta, Puragra; Gwyn, S. D. J.; Hudelot, Patrick; Mei, Simona; Toloba, Elisa

2016-11-01

The central region of the Virgo Cluster of galaxies contains thousands of globular clusters (GCs), an order of magnitude more than the number of clusters found in the Local Group. Relics of early star formation epochs in the universe, these GCs also provide ideal targets to test our understanding of the spectral energy distributions (SEDs) of old stellar populations. Based on photometric data from the Next Generation Virgo Cluster Survey (NGVS) and its near-infrared counterpart NGVS-IR, we select a robust sample of ≈ 2000 GCs with excellent photometry and tha span the full range of colors present in the Virgo core. The selection exploits the well-defined locus of GCs in the uiK diagram and the fact that the GCs are marginally resolved in the images. We show that the GCs define a narrow sequence in five-dimensional color space, with limited but real dispersion around the mean sequence. The comparison of these SEDs with the predictions of 11 widely used population synthesis models highlights differences between the models and also shows that no single model adequately matches the data in all colors. We discuss possible causes for some of these discrepancies. Forthcoming papers of this series will examine how best to estimate photometric metallicities in this context, and compare the Virgo GC colors with those in other environments.

Copy number variation of individual cattle genomes using next-generation sequencing

USDA-ARS?s Scientific Manuscript database

Copy Number Variations (CNVs) affect a wide range of phenotypic traits; however, CNVs in or near segmental duplication regions are often difficult to track. Using a read depth approach based on next generation sequencing, we examined genome-wide copy number differences among five taurine (three Angu...

The "Next Generation Science Standards" and the Earth and Space Sciences

ERIC Educational Resources Information Center

Wysession, Michael E.

2013-01-01

In this article, Michael E. Wysession comments on the "Next Generation Science Standards" (NGSS), which are based on the recommendations of the National Research Council and represent a revolutionary step toward establishing modern, national K-12 science education standards. The NGSS involves significant changes from traditional…

Methods for rapidly processing angular masks of next-generation galaxy surveys

NASA Astrophysics Data System (ADS)

Swanson, M. E. C.; Tegmark, Max; Hamilton, Andrew J. S.; Hill, J. Colin

2008-07-01

As galaxy surveys become larger and more complex, keeping track of the completeness, magnitude limit and other survey parameters as a function of direction on the sky becomes an increasingly challenging computational task. For example, typical angular masks of the Sloan Digital Sky Survey contain about N = 300000 distinct spherical polygons. Managing masks with such large numbers of polygons becomes intractably slow, particularly for tasks that run in time with a naive algorithm, such as finding which polygons overlap each other. Here we present a `divide-and-conquer' solution to this challenge: we first split the angular mask into pre-defined regions called `pixels', such that each polygon is in only one pixel, and then perform further computations, such as checking for overlap, on the polygons within each pixel separately. This reduces tasks to , and also reduces the important task of determining in which polygon(s) a point on the sky lies from to , resulting in significant computational speedup. Additionally, we present a method to efficiently convert any angular mask to and from the popular HEALPIX format. This method can be generically applied to convert to and from any desired spherical pixelization. We have implemented these techniques in a new version of the MANGLE software package, which is freely available at http://space.mit.edu/home/tegmark/mangle/, along with complete documentation and example applications. These new methods should prove quite useful to the astronomical community, and since MANGLE is a generic tool for managing angular masks on a sphere, it has the potential to benefit terrestrial mapmaking applications as well.

Fiscal Year 2014 Annual Report on BNLs Next Generation Safeguards Initiative Human Capital Development Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pepper, Susan E.

2014-10-10

Brookhaven National Laboratory’s (BNL’s) Nonproliferation and National Security Department contributes to the National Nuclear Security Administration Office of Nonproliferation and International Security Next Generation Safeguards Initiative (NGSI) through university engagement, safeguards internships, safeguards courses, professional development, recruitment, and other activities aimed at ensuring the next generation of international safeguards professionals is adequately prepared to support the U.S. safeguards mission. This report is a summary of BNL s work under the NGSI program in Fiscal Year 2014.

A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2

PubMed Central

Alsina, Jorge; Alsina, Raul; Gulec, Seza

2017-01-01

The next-generation sequencing technology allows high out-put genomic analysis. An innovative assay in thyroid cancer, ThyroSeq® was developed for targeted mutation detection by next generation sequencing technology in fine needle aspiration and tissue samples. ThyroSeq v.2 next generation sequencing panel offers simultaneous sequencing and detection in >1000 hotspots of 14 thyroid cancer-related genes and for 42 types of gene fusions known to occur in thyroid cancer. ThyroSeq is being increasingly used to further narrow the indeterminate category defined by cytology for thyroid nodules. From a surgical perspective, genomic profiling also provides prognostic and predictive information and closely relates to determination of surgical strategy. Both the genomic analysis technology and the informatics for the cancer genome data base are rapidly developing. In this paper, we have gathered existing information on the thyroid cancer-related genes involved in the initiation and progression of thyroid cancer. Our goal is to assemble a glossary for the current ThyroSeq genomic panel that can help elucidate the role genomics play in thyroid cancer oncogenesis. PMID:28117295

High-Oriented Polypyrrole Nanotubes for Next-Generation Gas Sensor.

PubMed

Xue, Mianqi; Li, Fengwang; Chen, Dong; Yang, Zhanhai; Wang, Xiaowei; Ji, Junhui

2016-10-01

Highly oriented PPy nanotubes are grown by in situ vapor phase polymerization within a nanoscale template under low temperature. As-fabricated PPy nanotubes are used for gas sensing, where an ultralow detection limit (0.05 ppb) and very fast response are achieved. Such an in situ mass-productive method for synthesizing highly oriented conducting polymers may pave a new step toward next-generation gas sensors. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Next Generation Qualification: Nanometrics T120PH Seismometer Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merchant, Bion J.; Slad, George William

2017-10-01

Sandia National Laboratories has tested and evaluated three seismometers, the Trillium 120PH, manufactured by Nanometrics. These seismometers measure broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self- noise, dynamic range, and self-calibration ability. The Nanometrics Trillium 120PH seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

Next Generation P-Band Planetary Synthetic Aperture Radar

NASA Technical Reports Server (NTRS)

Rincon, Rafael; Carter, Lynn; Lu, Dee Pong Daniel

2016-01-01

The Space Exploration Synthetic Aperture Radar (SESAR) is an advanced P-band beamforming radar instrument concept to enable a new class of observations suitable to meet Decadal Survey science goals for planetary exploration. The radar operates at full polarimetry and fine (meter scale) resolution, and achieves beam agility through programmable waveform generation and digital beamforming. The radar architecture employs a novel low power, lightweight design approach to meet stringent planetary instrument requirements. This instrument concept has the potential to provide unprecedented surface and near- subsurface measurements applicable to multiple DecadalSurvey Science Goals.

Next Generation P-Band Planetary Synthetic Aperture Radar

NASA Technical Reports Server (NTRS)

Rincon, Rafael; Carter, Lynn; Lu, Dee Pong Daniel

2017-01-01

The Space Exploration Synthetic Aperture Radar (SESAR) is an advanced P-band beamforming radar instrument concept to enable a new class of observations suitable to meet Decadal Survey science goals for planetary exploration. The radar operates at full polarimetry and fine (meter scale) resolution, and achieves beam agility through programmable waveform generation and digital beamforming. The radar architecture employs a novel low power, lightweight design approach to meet stringent planetary instrument requirements. This instrument concept has the potential to provide unprecedented surface and near- subsurface measurements applicable to multiple Decadal Survey Science Goals.

Fusion 2.0: The Next Generation of Fusion in California: Aligning State and Regional Fusion Centers

DTIC Science & Technology

2010-03-01

bible ” for fusion center management, as evidenced by the theme of the 2009 National Fusion Center Conference; appropriately called “Achieving Baseline...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS FUSION 2.0: THE NEXT GENERATION OF FUSION IN CALIFORNIA: ALIGNING STATE AND...Master’s Thesis 4. TITLE AND SUBTITLE Fusion 2.0: The Next Generation of Fusion in California: Aligning State and Regional Fusion

Preparing the Next Generation of School Administrators: Advice from Veteran Leaders

ERIC Educational Resources Information Center

Michael, Christine N.; Young, Nicholas D.

2006-01-01

The purpose of this study was to systematically gather advice and insights from veteran school leaders on how to prepare and support the next generation of educational administrators through professional development and mentoring programs. Two hundred school administrators who were members of the American Association of School Administrators were…

Teaching the "Geo" in Geography with the Next Generation Science Standards

ERIC Educational Resources Information Center

Wysession, Michael E.

2016-01-01

The Next Generation Science Standards (NGSS; Achieve 2014, 532; Figure 1A) represent a new approach to K-12 science education that involves the interweaving of three educational dimensions: Science and Engineering Practices (SEPs), Disciplinary Core Ideas (DCIs), and Crosscutting Concepts (CCCs). Unlike most preexisting state science standards for…

Overview of TPC Benchmark E: The Next Generation of OLTP Benchmarks

NASA Astrophysics Data System (ADS)

Hogan, Trish

Set to replace the aging TPC-C, the TPC Benchmark E is the next generation OLTP benchmark, which more accurately models client database usage. TPC-E addresses the shortcomings of TPC-C. It has a much more complex workload, requires the use of RAID-protected storage, generates much less I/O, and is much cheaper and easier to set up, run, and audit. After a period of overlap, it is expected that TPC-E will become the de facto OLTP benchmark.

The Next Generation Fornax Survey (NGFS). IV. Mass and Age Bimodality of Nuclear Clusters in the Fornax Core Region

NASA Astrophysics Data System (ADS)

Ordenes-Briceño, Yasna; Puzia, Thomas H.; Eigenthaler, Paul; Taylor, Matthew A.; Muñoz, Roberto P.; Zhang, Hongxin; Alamo-Martínez, Karla; Ribbeck, Karen X.; Grebel, Eva K.; Ángel, Simón; Côté, Patrick; Ferrarese, Laura; Hilker, Michael; Lançon, Ariane; Mieske, Steffen; Miller, Bryan W.; Rong, Yu; Sánchez-Janssen, Ruben

2018-06-01

We present the analysis of 61 nucleated dwarf galaxies in the central regions (≲R vir/4) of the Fornax galaxy cluster. The galaxies and their nuclei are studied as part of the Next Generation Fornax Survey using optical imaging obtained with the Dark Energy Camera mounted at Blanco/Cerro Tololo Inter-American Observatory and near-infrared data obtained with VIRCam at VISTA/ESO. We decompose the nucleated dwarfs in nucleus and spheroid, after subtracting the surface brightness profile of the spheroid component and studying the nucleus using point source photometry. In general, nuclei are consistent with colors of confirmed metal-poor globular clusters, but with significantly smaller dispersion than other confirmed compact stellar systems in Fornax. We find a bimodal nucleus mass distribution with peaks located at {log}({{ \\mathcal M }}* /{M}ȯ )≃ 5.4 and ∼6.3. These two nucleus subpopulations have different stellar population properties: the more massive nuclei are older than ∼2 Gyr and have metal-poor stellar populations (Z ≤ 0.02 Z ⊙), while the less massive nuclei are younger than ∼2 Gyr with metallicities in the range 0.02 < Z/Z ⊙ ≤ 1. We find that the nucleus mass ({{ \\mathcal M }}nuc}) versus galaxy mass ({{ \\mathcal M }}gal}) relation becomes shallower for less massive galaxies starting around 108 M ⊙, and the mass ratio {η }n={{ \\mathcal M }}nuc}/{{ \\mathcal M }}gal} shows a clear anticorrelation with {{ \\mathcal M }}gal} for the lowest masses, reaching 10%. We test current theoretical models of nuclear cluster formation and find that they cannot fully reproduce the observed trends. A likely mixture of in situ star formation and star cluster mergers seems to be acting during nucleus growth over cosmic time.

Molecular Diagnostics in Pathology: Time for a Next-Generation Pathologist?

PubMed

Fassan, Matteo

2018-03-01

- Comprehensive molecular investigations of mainstream carcinogenic processes have led to the use of effective molecular targeted agents in most cases of solid tumors in clinical settings. - To update readers regarding the evolving role of the pathologist in the therapeutic decision-making process and the introduction of next-generation technologies into pathology practice. - Current literature on the topic, primarily sourced from the PubMed (National Center for Biotechnology Information, Bethesda, Maryland) database, were reviewed. - Adequate evaluation of cytologic-based and tissue-based predictive diagnostic biomarkers largely depends on both proper pathologic characterization and customized processing of biospecimens. Moreover, increased requests for molecular testing have paralleled the recent, sharp decrease in tumor material to be analyzed-material that currently comprises cytology specimens or, at minimum, small biopsies in most cases of metastatic/advanced disease. Traditional diagnostic pathology has been completely revolutionized by the introduction of next-generation technologies, which provide multigene, targeted mutational profiling, even in the most complex of clinical cases. Combining traditional and molecular knowledge, pathologists integrate the morphological, clinical, and molecular dimensions of a disease, leading to a proper diagnosis and, therefore, the most-appropriate tailored therapy.

High-performance ferroelectric and magnetoresistive materials for next-generation thermal detector arrays

NASA Astrophysics Data System (ADS)

Todd, Michael A.; Donohue, Paul P.; Watton, Rex; Williams, Dennis J.; Anthony, Carl J.; Blamire, Mark G.

2002-12-01

This paper discusses the potential thermal imaging performance achievable from thermal detector arrays and concludes that the current generation of thin-film ferroelectric and resistance bolometer based detector arrays are limited by the detector materials used. It is proposed that the next generation of large uncooled focal plane arrays will need to look towards higher performance detector materials - particularly if they aim to approach the fundamental performance limits and compete with cooled photon detector arrays. Two examples of bolometer thin-film materials are described that achieve high performance from operating around phase transitions. The material Lead Scandium Tantalate (PST) has a paraelectric-to-ferroelectric phase transition around room temperature and is used with an applied field in the dielectric bolometer mode for thermal imaging. PST films grown by sputtering and liquid-source CVD have shown merit figures for thermal imaging a factor of 2 to 3 times higher than PZT-based pyroelectric thin films. The material Lanthanum Calcium Manganite (LCMO) has a paramagnetic to ferromagnetic phase transition around -20oC. This paper describes recent measurements of TCR and 1/f noise in pulsed laser-deposited LCMO films on Neodymium Gallate substrates. These results show that LCMO not only has high TCR's - up to 30%/K - but also low 1/f excess noise, with bolometer merit figures at least an order of magnitude higher than Vanadium Oxide, making it ideal for the next generation of microbolometer arrays. These high performance properties come at the expense of processing complexities and novel device designs will need to be introduced to realize the potential of these materials in the next generation of thermal detectors.

Next generation platforms for high-throughput biodosimetry.

PubMed

Repin, Mikhail; Turner, Helen C; Garty, Guy; Brenner, David J

2014-06-01

Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of biodosimetry assays was described. These platforms can be used at different stages of biodosimetry assays starting from blood collection into microtubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multiwell and multichannel plates. Robotically friendly platforms can be used for different biodosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Next Generation Emission Measurements for Fugitive, Area Source, and Fence Line Applications?

EPA Science Inventory

Next generation emissions measurements (NGEM) is an EPA term for the rapidly advancing field of air pollutant sensor technologies, data integration concepts, and associated geospatial modeling strategies for source emissions measurements. Ranging from low coat sensors to satelli...

The next generation rocket engines

NASA Astrophysics Data System (ADS)

Beichel, Rudi; O'Brien, Charles J.; Taylor, James P.

This paper examines propulsion system technologies for earth-to-orbit vehicles, and describes several propulsion system concepts which could support the recommendations of the Commission for Space Development for the year 2000. The hallmark of that system must and will be reliability. Reliability will be obtained through a very structured design approach, coupled with a rational, cost effective, development and qualification program. To improve the next generation space transportation propulsion systems we need to select the very best of alternative power and performance cycles and engine physical concepts with a rigid requirement to achieve a robust, dependable, affordable propulsion system. For example, engine concepts using either propellants or non-propellant fluids for cooling and/or power drive offer the potential to provide smooth, controlled engine starts, low turbine temperatures, etc. as required for long life turbomachinery. Concepts examined are LOX/LH 2, |LOX/LH 2 + hydrocarbon, and LOX/LH 2 + hydrocarbon + Al dual expander engines, separate LOX/LH 2 and LOX/hydrocarbon engines, and variable mixture ratio engines. A fully reusable propulsion system that is perceived to be very low risk and low in operation cost is described.

NOAO's next-generation optical spectrograph

NASA Astrophysics Data System (ADS)

Barden, Samuel C.; Harmer, Charles F.; Blakley, Rick D.; Parks, Rachel J.

2000-08-01

The National Optical Astronomy Observatory is developing a new, wide-field, imaging spectrograph for use on its existing 4-meter telescopes. This Next Generation Optical Spectrograph (NGOS) will utilize volume-phase holographic grating technology and will have a mosaiced detector array to image the spectra over a field of view that will be something like 10.5 by 42 arc-minutes on the sky. The overall efficiency of the spectrograph should be quite high allowing it to outperform the current RC spectrograph by factors of 10 to 20 and the Hydra multi-fiber instrument by a facto of fiber to ten per object. The operational range of the instrument will allow observations within the optical and near-IR regions. Spectral resolutions will go from R equals 1000 to at least R equals 5000 with 1.4 arc-second slits. The large size of this instrument, with a beam diameter of 200 mm and an overall length of nearly 3 meters, presents a significant challenge in mounting it at the Cassegrain location of the telescope. Design trades and options that allow it to fit are discussed.

NNSA Program Develops the Next Generation of Nuclear Security Experts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brim, Cornelia P.; Disney, Maren V.

2015-09-02

NNSA is fostering the next generation of nuclear security experts is through its successful NNSA Graduate Fellowship Program (NGFP). NGFP offers its Fellows an exceptional career development opportunity through hands-on experience supporting NNSA mission areas across policy and technology disciplines. The one-year assignments give tomorrow’s leaders in global nuclear security and nonproliferation unparalleled exposure through assignments to Program Offices across NNSA.

NREL Next Generation Drivetrain: Mechanical Design and Test Plan (Poster)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, J.; Halse, C.

The Department of Energy and industry partners are sponsoring a $3m project for design and testing of a 'Next Generation' wind turbine drivetrain at the National Renewable Energy Laboratory (NREL). This poster focuses on innovative aspects of the gearbox design, completed as part of an end-to-end systems engineering approach incorporating innovations that increase drivetrain reliability, efficiency, torque density and minimize capital cost.

Next Generation Qualification: Kinemetrics STS-5A Seismometer Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merchant, Bion John; Slad, George William

2017-10-01

Sandia National Laboratories has tested and evaluated two seismometers, the STS-5A, manufactured by Kinemetrics. These seismometers measure three axes of broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self-noise, dynamic range, and self-calibration ability. The Kinemetrics STS-5A seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

X-ray microlensing in the quadruply lensed quasar Q2237+0305

NASA Astrophysics Data System (ADS)

Zimmer, F.; Schmidt, R. W.; Wambsganss, J.

2011-05-01

We use archival data of NASA's Chandra X-ray telescope to compile an X-ray light curve of all four images of the quadruply lensed quasar Q2237+0305 (zQ= 1.695) from 2006 January to 2007 January. We fit simulated point spread functions to the four individual quasar images using Cash's C-statistic to account for the Poissonian nature of the X-ray signal. The quasar images display strong flux variations up to a factor of ˜4 within one month. We can disentangle the intrinsic quasar variability from flux variations due to gravitational microlensing by looking at the flux ratios of the individual quasar images. Doing this, we find evidence for microlensing in image A. In particular, the time sequence of the flux ratio A/B in the X-ray regime correlates with the corresponding sequence in the optical monitoring by OGLE in the V band. The amplitudes in the X-ray light curve are larger. For the most prominent peak, the increase of the X-ray ratio A/B is larger by a factor of ˜1.6 compared to the signal in the optical. In agreement with theory and other observations of multiply-imaged quasars, this suggests that the X-ray emission region of this quasar is significantly smaller than the optical emission region.

Next Generation Air Measurements for Fugitive, Area Source, and Fence Line Applications

EPA Science Inventory

Next generation air measurements (NGAM) is an EPA term for the advancing field of air pollutant sensor technologies, data integration concepts, and geospatial modeling strategies. Ranging from personal sensors to satellite remote sensing, NGAM systems may provide revolutionary n...

Next generation agricultural system data, models and knowledge products: Introduction.

PubMed

Antle, John M; Jones, James W; Rosenzweig, Cynthia E

2017-07-01

Agricultural system models have become important tools to provide predictive and assessment capability to a growing array of decision-makers in the private and public sectors. Despite ongoing research and model improvements, many of the agricultural models today are direct descendants of research investments initially made 30-40 years ago, and many of the major advances in data, information and communication technology (ICT) of the past decade have not been fully exploited. The purpose of this Special Issue of Agricultural Systems is to lay the foundation for the next generation of agricultural systems data, models and knowledge products. The Special Issue is based on a "NextGen" study led by the Agricultural Model Intercomparison and Improvement Project (AgMIP) with support from the Bill and Melinda Gates Foundation.

Next Generation Agricultural System Data, Models and Knowledge Products: Introduction

NASA Technical Reports Server (NTRS)

Antle, John M.; Jones, James W.; Rosenzweig, Cynthia E.

2016-01-01

Agricultural system models have become important tools to provide predictive and assessment capability to a growing array of decision-makers in the private and public sectors. Despite ongoing research and model improvements, many of the agricultural models today are direct descendants of research investments initially made 30-40 years ago, and many of the major advances in data, information and communication technology (ICT) of the past decade have not been fully exploited. The purpose of this Special Issue of Agricultural Systems is to lay the foundation for the next generation of agricultural systems data, models and knowledge products. The Special Issue is based on a 'NextGen' study led by the Agricultural Model Intercomparison and Improvement Project (AgMIP) with support from the Bill and Melinda Gates Foundation.

Social Intelligence: Next Generation Business Intelligence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Troy Hiltbrand

In order for Business Intelligence to truly move beyond where it is today, a shift in approach must occur. Currently, much of what is accomplished in the realm of Business Intelligence relies on reports and dashboards to summarize and deliver information to end users. As we move into the future, we need to get beyond these reports and dashboards to a point where we break out the individual metrics that are embedded in these reports and interact with these components independently. Breaking these pieces of information out of the confines of reports and dashboards will allow them to be dynamicallymore » assembled for delivery in the way that makes most sense to each consumer. With this change in ideology, Business Intelligence will move from the concept of collections of objects, or reports and dashboards, to individual objects, or information components. The Next Generation Business Intelligence suite will translate concepts popularized in Facebook, Flickr, and Digg into enterprise worthy communication vehicles.« less

Astro Data Science: The Next Generation

NASA Astrophysics Data System (ADS)

Mentzel, Chris

2018-01-01

Astronomers have been at the forefront of data-driven discovery since before the days of Kepler. Using data in the scientific inquiry into the workings of the the universe is the lifeblood of the field. This said, data science is considered a new thing, and researchers from every discipline are rushing to learn data science techniques, train themselves on data science tools, and even leaving academia to become data scientists. It is undeniable that our ability to harness new computational and statistical methods to make sense of today’s unprecedented size, complexity, and fast streaming data is helping scientists make new discoveries. The question now is how to ensure that researchers can employ these tools and use them appropriately. This talk will cover the state of data science as it relates to scientific research and the role astronomers play in its development, use, and training the next generation of astro-data scientists.

Comparison of Next-Generation Sequencing Systems

PubMed Central

Liu, Lin; Li, Yinhu; Li, Siliang; Hu, Ni; He, Yimin; Pong, Ray; Lin, Danni; Lu, Lihua; Law, Maggie

2012-01-01

With fast development and wide applications of next-generation sequencing (NGS) technologies, genomic sequence information is within reach to aid the achievement of goals to decode life mysteries, make better crops, detect pathogens, and improve life qualities. NGS systems are typically represented by SOLiD/Ion Torrent PGM from Life Sciences, Genome Analyzer/HiSeq 2000/MiSeq from Illumina, and GS FLX Titanium/GS Junior from Roche. Beijing Genomics Institute (BGI), which possesses the world's biggest sequencing capacity, has multiple NGS systems including 137 HiSeq 2000, 27 SOLiD, one Ion Torrent PGM, one MiSeq, and one 454 sequencer. We have accumulated extensive experience in sample handling, sequencing, and bioinformatics analysis. In this paper, technologies of these systems are reviewed, and first-hand data from extensive experience is summarized and analyzed to discuss the advantages and specifics associated with each sequencing system. At last, applications of NGS are summarized. PMID:22829749

Automotive Radar and Lidar Systems for Next Generation Driver Assistance Functions

NASA Astrophysics Data System (ADS)

Rasshofer, R. H.; Gresser, K.

2005-05-01

Automotive radar and lidar sensors represent key components for next generation driver assistance functions (Jones, 2001). Today, their use is limited to comfort applications in premium segment vehicles although an evolution process towards more safety-oriented functions is taking place. Radar sensors available on the market today suffer from low angular resolution and poor target detection in medium ranges (30 to 60m) over azimuth angles larger than ±30°. In contrast, Lidar sensors show large sensitivity towards environmental influences (e.g. snow, fog, dirt). Both sensor technologies today have a rather high cost level, forbidding their wide-spread usage on mass markets. A common approach to overcome individual sensor drawbacks is the employment of data fusion techniques (Bar-Shalom, 2001). Raw data fusion requires a common, standardized data interface to easily integrate a variety of asynchronous sensor data into a fusion network. Moreover, next generation sensors should be able to dynamically adopt to new situations and should have the ability to work in cooperative sensor environments. As vehicular function development today is being shifted more and more towards virtual prototyping, mathematical sensor models should be available. These models should take into account the sensor's functional principle as well as all typical measurement errors generated by the sensor.

The next generation of Palapa satellite (Palapa-C)

NASA Astrophysics Data System (ADS)

Setiawan, Bambang

The Indonesian Palapa Communication Satellite System was established in Aug. 1976 when the first satellite of Palapa A series (Palapa A1) began operation. The system is owned and operated by PT. Telekomunikasi Indonesia (Telkom), which is a state owned company. The purpose of the system was to unify the telecommunications of the nation. Many years of operation have shown that satellite technology is the best solution for improving telecommunications in Indonesia. The system was started with 2 (two) satellites, each with 12 transponders (for a total of 24), and 40 earth stations. Now the system has 3 (three) satellites, each with 24 transponders (for a total of 72 transponders), and thousands of earth stations. The services have been extended to satisfy the requirements of the region as well as the original objectives. The use of satellite transponders in the region is increasing rapidly. In the next ten years, opportunities in the satellite communications business will become even more attractive. The next generation Palapa-C will incorporate improvements in capacity, quality, and coverage. The new frequency bands (ku- and Extended-C Band) will be used to meet the new transponder capacity requirements.

Generation of a novel next-generation sequencing-based method for the isolation of new human papillomavirus types.

PubMed

Brancaccio, Rosario N; Robitaille, Alexis; Dutta, Sankhadeep; Cuenin, Cyrille; Santare, Daiga; Skenders, Girts; Leja, Marcis; Fischer, Nicole; Giuliano, Anna R; Rollison, Dana E; Grundhoff, Adam; Tommasino, Massimo; Gheit, Tarik

2018-05-07

With the advent of new molecular tools, the discovery of new papillomaviruses (PVs) has accelerated during the past decade, enabling the expansion of knowledge about the viral populations that inhabit the human body. Human PVs (HPVs) are etiologically linked to benign or malignant lesions of the skin and mucosa. The detection of HPV types can vary widely, depending mainly on the methodology and the quality of the biological sample. Next-generation sequencing is one of the most powerful tools, enabling the discovery of novel viruses in a wide range of biological material. Here, we report a novel protocol for the detection of known and unknown HPV types in human skin and oral gargle samples using improved PCR protocols combined with next-generation sequencing. We identified 105 putative new PV types in addition to 296 known types, thus providing important information about the viral distribution in the oral cavity and skin. Copyright © 2018. Published by Elsevier Inc.

Late-time high-resolution images of the black hole candidate microlensing events, MACHO-96-BLG-5 and MACHO-98-BLG-6

NASA Astrophysics Data System (ADS)

Forest Stephens, Haynes; Lu, Jessica

2018-01-01