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Sample records for nonbinary quantum cyclic

  1. Nonlinear, nonbinary cyclic group codes

    NASA Technical Reports Server (NTRS)

    Solomon, G.

    1992-01-01

    New cyclic group codes of length 2(exp m) - 1 over (m - j)-bit symbols are introduced. These codes can be systematically encoded and decoded algebraically. The code rates are very close to Reed-Solomon (RS) codes and are much better than Bose-Chaudhuri-Hocquenghem (BCH) codes (a former alternative). The binary (m - j)-tuples are identified with a subgroup of the binary m-tuples which represents the field GF(2 exp m). Encoding is systematic and involves a two-stage procedure consisting of the usual linear feedback register (using the division or check polynomial) and a small table lookup. For low rates, a second shift-register encoding operation may be invoked. Decoding uses the RS error-correcting procedures for the m-tuple codes for m = 4, 5, and 6.

  2. Constructions of new families of nonbinary quantum codes

    SciTech Connect

    La Guardia, Giuliano G.

    2009-10-15

    Three code constructions generating new families of good nonbinary quantum codes are presented in this paper. The first two ones are derived from Hermitian self-orthogonal non-narrow-sense Bose-Chaudhuri-Hocquenghem (BCH) codes. The third one is derived from q-ary (q{ne}2 is a prime power) Steane's enlargement of Calderbank-Shor-Steane codes applied to Euclidean self-orthogonal non-narrow-sense BCH codes. The quantum nonbinary BCH codes presented here have parameters better than the ones available in the literature.

  3. Non-binary unitary error bases and quantum codes

    SciTech Connect

    Knill, E.

    1996-06-01

    Error operator bases for systems of any dimension are defined and natural generalizations of the bit-flip/ sign-change error basis for qubits are given. These bases allow generalizing the construction of quantum codes based on eigenspaces of Abelian groups. As a consequence, quantum codes can be constructed form linear codes over {ital Z}{sub {ital n}} for any {ital n}. The generalization of the punctured code construction leads to many codes which permit transversal (i.e. fault tolerant) implementations of certain operations compatible with the error basis.

  4. Cyclic universe from Loop Quantum Gravity

    NASA Astrophysics Data System (ADS)

    Cianfrani, Francesco; Kowalski-Glikman, Jerzy; Rosati, Giacomo

    2016-02-01

    We discuss how a cyclic model for the flat universe can be constructively derived from Loop Quantum Gravity. This model has a lower bounce, at small values of the scale factor, which shares many similarities with that of Loop Quantum Cosmology. We find that Quantum Gravity corrections can be also relevant at energy densities much smaller than the Planckian one and that they can induce an upper bounce at large values of the scale factor.

  5. Quantum diffusion on a cyclic one-dimensional lattice

    NASA Astrophysics Data System (ADS)

    de La Torre, A. C.; Mártin, H. O.; Goyeneche, D.

    2003-09-01

    The quantum diffusion of a particle in an initially localized state on a cyclic lattice with N sites is studied. Diffusion and reconstruction time are calculated. Strong differences are found for even or odd number of sites and the limit N→∞ is studied. The predictions of the model could be tested with microtechnology and nanotechnology devices.

  6. Reconciliation with Non-Binary Species Trees

    PubMed Central

    Vernot, Benjamin; Stolzer, Maureen; Goldman, Aiton

    2008-01-01

    Abstract Reconciliation extracts information from the topological incongruence between gene and species trees to infer duplications and losses in the history of a gene family. The inferred duplication-loss histories provide valuable information for a broad range of biological applications, including ortholog identification, estimating gene duplication times, and rooting and correcting gene trees. While reconciliation for binary trees is a tractable and well studied problem, there are no algorithms for reconciliation with non-binary species trees. Yet a striking proportion of species trees are non-binary. For example, 64% of branch points in the NCBI taxonomy have three or more children. When applied to non-binary species trees, current algorithms overestimate the number of duplications because they cannot distinguish between duplication and incomplete lineage sorting. We present the first algorithms for reconciling binary gene trees with non-binary species trees under a duplication-loss parsimony model. Our algorithms utilize an efficient mapping from gene to species trees to infer the minimum number of duplications in O(|VG| · (kS + hS)) time, where |VG| is the number of nodes in the gene tree, hS is the height of the species tree and kS is the size of its largest polytomy. We present a dynamic programming algorithm which also minimizes the total number of losses. Although this algorithm is exponential in the size of the largest polytomy, it performs well in practice for polytomies with outdegree of 12 or less. We also present a heuristic which estimates the minimal number of losses in polynomial time. In empirical tests, this algorithm finds an optimal loss history 99% of the time. Our algorithms have been implemented in Notung, a robust, production quality, tree-fitting program, which provides a graphical user interface for exploratory analysis and also supports automated, high-throughput analysis of large data sets. PMID:18808330

  7. Non-binary or genderqueer genders.

    PubMed

    Richards, Christina; Bouman, Walter Pierre; Seal, Leighton; Barker, Meg John; Nieder, Timo O; T'Sjoen, Guy

    2016-01-01

    Some people have a gender which is neither male nor female and may identify as both male and female at one time, as different genders at different times, as no gender at all, or dispute the very idea of only two genders. The umbrella terms for such genders are 'genderqueer' or 'non-binary' genders. Such gender identities outside of the binary of female and male are increasingly being recognized in legal, medical and psychological systems and diagnostic classifications in line with the emerging presence and advocacy of these groups of people. Population-based studies show a small percentage--but a sizable proportion in terms of raw numbers--of people who identify as non-binary. While such genders have been extant historically and globally, they remain marginalized, and as such--while not being disorders or pathological in themselves--people with such genders remain at risk of victimization and of minority or marginalization stress as a result of discrimination. This paper therefore reviews the limited literature on this field and considers ways in which (mental) health professionals may assist the people with genderqueer and non-binary gender identities and/or expressions they may see in their practice. Treatment options and associated risks are discussed. PMID:26753630

  8. Advanced GF(32) nonbinary LDPC coded modulation with non-uniform 9-QAM outperforming star 8-QAM.

    PubMed

    Liu, Tao; Lin, Changyu; Djordjevic, Ivan B

    2016-06-27

    In this paper, we first describe a 9-symbol non-uniform signaling scheme based on Huffman code, in which different symbols are transmitted with different probabilities. By using the Huffman procedure, prefix code is designed to approach the optimal performance. Then, we introduce an algorithm to determine the optimal signal constellation sets for our proposed non-uniform scheme with the criterion of maximizing constellation figure of merit (CFM). The proposed nonuniform polarization multiplexed signaling 9-QAM scheme has the same spectral efficiency as the conventional 8-QAM. Additionally, we propose a specially designed GF(32) nonbinary quasi-cyclic LDPC code for the coded modulation system based on the 9-QAM non-uniform scheme. Further, we study the efficiency of our proposed non-uniform 9-QAM, combined with nonbinary LDPC coding, and demonstrate by Monte Carlo simulation that the proposed GF(23) nonbinary LDPC coded 9-QAM scheme outperforms nonbinary LDPC coded uniform 8-QAM by at least 0.8dB. PMID:27410549

  9. Experimental study of non-binary LDPC coding for long-haul coherent optical QPSK transmissions.

    PubMed

    Zhang, Shaoliang; Arabaci, Murat; Yaman, Fatih; Djordjevic, Ivan B; Xu, Lei; Wang, Ting; Inada, Yoshihisa; Ogata, Takaaki; Aoki, Yasuhiro

    2011-09-26

    The performance of rate-0.8 4-ary LDPC code has been studied in a 50 GHz-spaced 40 Gb/s DWDM system with PDM-QPSK modulation. The net effective coding gain of 10 dB is obtained at BER of 10(-6). With the aid of time-interleaving polarization multiplexing and MAP detection, 10,560 km transmission over legacy dispersion managed fiber is achieved without any countable errors. The proposed nonbinary quasi-cyclic LDPC code achieves an uncoded BER threshold at 4×10(-2). Potential issues like phase ambiguity and coding length are also discussed when implementing LDPC in current coherent optical systems. PMID:21996844

  10. Towards Noncommutative Topological Quantum Field Theory - Hodge theory for cyclic cohomology

    NASA Astrophysics Data System (ADS)

    Zois, I. P.

    2014-03-01

    Some years ago we initiated a program to define Noncommutative Topological Quantum Field Theory (see [1]). The motivation came both from physics and mathematics: On the one hand, as far as physics is concerned, following the well-known holography principle of 't Hooft (which in turn appears essentially as a generalisation of the Hawking formula for black hole entropy), quantum gravity should be a topological quantum field theory. On the other hand as far as mathematics is concerned, the motivation came from the idea to replace the moduli space of flat connections with the Gabai moduli space of codim-1 taut foliations for 3 dim manifolds. In most cases the later is finite and much better behaved and one might use it to define some version of Donaldson-Floer homology which, hopefully, would be easier to compute. The use of foliations brings noncommutative geometry techniques immediately into the game. The basic tools are two: Cyclic cohomology of the corresponding foliation C*-algebra and the so called "tangential cohomology" of the foliation. A necessary step towards this goal is to develop some sort of Hodge theory both for cyclic (and Hochschild) cohomology and for tangential cohomology. Here we present a method to develop a Hodge theory for cyclic and Hochschild cohomology for the corresponding C*-algebra of a foliation.

  11. Quantum codes from cyclic codes over F_q+uF_q+vF_q+uvF_q

    NASA Astrophysics Data System (ADS)

    Ashraf, Mohammad; Mohammad, Ghulam

    2016-07-01

    In this paper, we study quantum codes over F_q from cyclic codes over F_q+uF_q+vF_q+uvF_q, where u^2=u,~v^2=v,~uv=vu,~q=p^m , and p is an odd prime. We give the structure of cyclic codes over F_q+uF_q+vF_q+uvF_q and obtain self-orthogonal codes over F_q as Gray images of linear and cyclic codes over F_q+uF_q+vF_q+uvF_q . In particular, we decompose a cyclic code over F_q+uF_q+vF_q+uvF_q into four cyclic codes over F_q to determine the parameters of the corresponding quantum code.

  12. Creation of particles in a cyclic universe driven by loop quantum cosmology

    NASA Astrophysics Data System (ADS)

    Tavakoli, Yaser; Fabris, Júlio C.

    2015-05-01

    We consider an isotropic and homogeneous universe in loop quantum cosmology (LQC). We assume that the matter content of the universe is dominated by dust matter in early time and a phantom matter at late time which constitutes the dark energy component. The quantum gravity modifications to the Friedmann equation in this model indicate that the classical big bang singularity and the future big rip singularity are resolved and are replaced by quantum bounce. It turns out that the big bounce and recollapse in the herein model contribute to a cyclic scenario for the universe. We then study the quantum theory of a massive, nonminimally coupled scalar field undergoing cosmological evolution from primordial bounce towards the late time bounce. In particular, we solve the Klein-Gordon equation for the scalar field in the primordial and late time regions, in order to investigate particle production phenomena at late time. By computing the energy density of created particles at late time, we show that this density is negligible in comparison to the quantum background density at Planck era. This indicates that the effects of quantum particle production do not influence the future bounce.

  13. Error Correction using Quantum Quasi-Cyclic Low-Density Parity-Check(LDPC) Codes

    NASA Astrophysics Data System (ADS)

    Jing, Lin; Brun, Todd; Quantum Research Team

    Quasi-cyclic LDPC codes can approach the Shannon capacity and have efficient decoders. Manabu Hagiwara et al., 2007 presented a method to calculate parity check matrices with high girth. Two distinct, orthogonal matrices Hc and Hd are used. Using submatrices obtained from Hc and Hd by deleting rows, we can alter the code rate. The submatrix of Hc is used to correct Pauli X errors, and the submatrix of Hd to correct Pauli Z errors. We simulated this system for depolarizing noise on USC's High Performance Computing Cluster, and obtained the block error rate (BER) as a function of the error weight and code rate. From the rates of uncorrectable errors under different error weights we can extrapolate the BER to any small error probability. Our results show that this code family can perform reasonably well even at high code rates, thus considerably reducing the overhead compared to concatenated and surface codes. This makes these codes promising as storage blocks in fault-tolerant quantum computation. Error Correction using Quantum Quasi-Cyclic Low-Density Parity-Check(LDPC) Codes.

  14. Cyclic voltammetry as a sensitive method for in situ probing of chemical transformations in quantum dots.

    PubMed

    Osipovich, Nikolai P; Poznyak, Sergei K; Lesnyak, Vladimir; Gaponik, Nikolai

    2016-04-21

    The application of electrochemical methods for the characterization of colloidal quantum dots (QDs) attracts considerable attention as these methods may allow for monitoring of some crucial parameters, such as energetic levels of conduction and valence bands as well as surface traps and ligands under real conditions of colloidal solution. In the present work we extend the applications of cyclic voltammetry (CV) to in situ monitoring of degradation processes of water-soluble CdTe QDs. This degradation occurs under lowering of pH to the values around 5, i.e. under conditions relevant to bioimaging applications of these QDs, and is accompanied by pronounced changes of their photoluminescence. Observed correlations between characteristic features of CV diagrams and the fluorescence spectra allowed us to propose mechanisms responsible for evolution of the photoluminescence properties as well as degradation pathway of CdTe QDs at low pH. PMID:27025663

  15. Big-bounce cosmology from quantum gravity: The case of a cyclical Bianchi I universe

    NASA Astrophysics Data System (ADS)

    Moriconi, Riccardo; Montani, Giovanni; Capozziello, Salvatore

    2016-07-01

    We analyze the classical and quantum dynamics of a Bianchi I model in the presence of a small negative cosmological constant characterizing its evolution in term of the dust-time dualism. We demonstrate that in a canonical metric approach, the cosmological singularity is removed in correspondence to a positive defined value of the dust energy density. Furthermore, the quantum big bounce is connected to the Universe's turning point via a well-defined semiclassical limit. Then we can reliably infer that the proposed scenario is compatible with a cyclical universe picture. We also show how, when the contribution of the dust energy density is sufficiently high, the proposed scenario can be extended to the Bianchi IX cosmology and therefore how it can be regarded as a paradigm for the generic cosmological model. Finally, we investigate the origin of the observed cutoff on the cosmological dynamics, demonstrating how the big-bounce evolution can be mimicked by the same semiclassical scenario, where the negative cosmological constant is replaced via a polymer discretization of the Universe's volume. A direct proportionality law between these two parameters is then established.

  16. Structure of the solution of the time-dependent Schrödinger equation, universal existence of the cyclic quantum evolution, and geometric phases

    NASA Astrophysics Data System (ADS)

    Wu, Lian-Ao

    1994-12-01

    It is shown that the cyclic evolution posed by Aharonov and Anandan [Phys. Rev. Lett. 58, 1593 (1987)] universally exists in any quantum system: cyclic evolution occurs for special initial wave functions, whatever the concrete form of the Hamiltonian. The above results are illustrated and some specific geometric phases are given.

  17. Where Kinsey, Christ, and Tila Tequila meet: discourse and the sexual (non)-binary.

    PubMed

    Callis, April S

    2014-01-01

    Drawing on 80 interviews and 17 months of participant observation in Lexington, Kentucky, this article details how individuals drew on three areas of national and local discourse to conceptualize sexuality. Media, popular science, and religious discourses can be viewed as portraying sexuality bifocally--as both a binary of heterosexual/homosexual and as a non-binary that encompasses fluidity. However, individuals in Lexington drew on each of these areas of discourse differently. Religion was thought to produce a binary vision of sexuality, whereas popular science accounts were understood as both binary and not. The media was understood as portraying non-binary identities that were not viable, thus strengthening the sexual binary. These differing points of view led identities such as bisexual and queer to lack cultural intelligibility. PMID:25089615

  18. Capacity achieving nonbinary LDPC coded non-uniform shaping modulation for adaptive optical communications.

    PubMed

    Lin, Changyu; Zou, Ding; Liu, Tao; Djordjevic, Ivan B

    2016-08-01

    A mutual information inspired nonbinary coded modulation design with non-uniform shaping is proposed. Instead of traditional power of two signal constellation sizes, we design 5-QAM, 7-QAM and 9-QAM constellations, which can be used in adaptive optical networks. The non-uniform shaping and LDPC code rate are jointly considered in the design, which results in a better performance scheme for the same SNR values. The matched nonbinary (NB) LDPC code is used for this scheme, which further improves the coding gain and the overall performance. We analyze both coding performance and system SNR performance. We show that the proposed NB LDPC-coded 9-QAM has more than 2dB gain in symbol SNR compared to traditional LDPC-coded star-8-QAM. On the other hand, the proposed NB LDPC-coded 5-QAM and 7-QAM have even better performance than LDPC-coded QPSK. PMID:27505775

  19. On the correspondence of semiclassical and quantum phases in cyclic evolutions

    SciTech Connect

    Benedict, M.G. ); Schleich, W. )

    1993-03-01

    Based on the exactly solvable case of a harmonic oscillator, the authors show that the direct correspondence between the Bohr-Sommerfeld phase of semiclassical quantum mechanics and the topological phase of Aharonov and Anandan is restricted to the case of a coherent state. For other Gaussian wave packets the geometric quantum phase strongly depends on the amount of squeezing. 12 refs.

  20. Quantum-chemical modeling of energy parameters and vibrational spectra of chain and cyclic clusters of monohydric alcohols

    NASA Astrophysics Data System (ADS)

    Golub, P.; Doroshenko, I.; Pogorelov, V.

    2014-05-01

    The specific peculiarities of alcohols such as heightened viscosity, boiling temperature and surface tension can be explained by the capability of their molecules to form relatively stable associates named clusters due to hydrogen bonding. In present work the stability of different chain-like and cyclic clusters of methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol and 1-hexanol was investigated by means of quantum-chemical simulation and particular by recently developed DFT exchange-correlation functional M06-2X. The relative stability of the cluster structure was evaluated by the total energy per molecule at low temperatures (where all alcohols exist in solid state) and by the changing of the free Gibbs energy upon cluster formation at the room temperature. For the verification of revealed results the conformity of calculated IR spectra of the most stable cluster structures with the experimental IR spectra at different temperatures was analyzed.

  1. Oscillations of the energy, magnetic moment, and current with a period equal to the normal or superconducting flux quantum in cyclic systems

    SciTech Connect

    Svirskii, M.S.

    1985-09-10

    Oscillations with a period equal to the normal or superconducting flux quantum occur in the current density and the orbital parts of the energy and the magnetic moment in cyclic systems. Transitions between these regimes can be induced by changing the number of electrons or by switching between states with different energies.

  2. Inferring duplications, losses, transfers and incomplete lineage sorting with nonbinary species trees

    PubMed Central

    Stolzer, Maureen; Lai, Han; Xu, Minli; Sathaye, Deepa; Vernot, Benjamin; Durand, Dannie

    2012-01-01

    Motivation: Gene duplication (D), transfer (T), loss (L) and incomplete lineage sorting (I) are crucial to the evolution of gene families and the emergence of novel functions. The history of these events can be inferred via comparison of gene and species trees, a process called reconciliation, yet current reconciliation algorithms model only a subset of these evolutionary processes. Results: We present an algorithm to reconcile a binary gene tree with a nonbinary species tree under a DTLI parsimony criterion. This is the first reconciliation algorithm to capture all four evolutionary processes driving tree incongruence and the first to reconcile non-binary species trees with a transfer model. Our algorithm infers all optimal solutions and reports complete, temporally feasible event histories, giving the gene and species lineages in which each event occurred. It is fixed-parameter tractable, with polytime complexity when the maximum species outdegree is fixed. Application of our algorithms to prokaryotic and eukaryotic data show that use of an incomplete event model has substantial impact on the events inferred and resulting biological conclusions. Availability: Our algorithms have been implemented in Notung, a freely available phylogenetic reconciliation software package, available at http://www.cs.cmu.edu/~durand/Notung. Contact: mstolzer@andrew.cmu.edu PMID:22962460

  3. Cyclic Polyynes as Examples of the Quantum Mechanical Particle on a Ring

    ERIC Educational Resources Information Center

    Anderson, Bruce D.

    2012-01-01

    Many quantum mechanical models are discussed as part of the undergraduate physical chemistry course to help students understand the connection between eigenvalue expressions and spectroscopy. Typical examples covered include the particle in a box, the harmonic oscillator, the rigid rotor, and the hydrogen atom. This article demonstrates that…

  4. Quantum routing of single photons with a cyclic three-level system.

    PubMed

    Zhou, Lan; Yang, Li-Ping; Li, Yong; Sun, C P

    2013-09-01

    We propose an experimentally accessible single-photon routing scheme using a △-type three-level atom embedded in quantum multichannels composed of coupled-resonator waveguides. Via the on-demand classical field being applied to the atom, the router can extract a single photon from the incident channel, and then redirect it into another. The efficient function of the perfect reflection of the single-photon signal in the incident channel is rooted in the coherent resonance and the existence of photonic bound states. PMID:25166667

  5. Competitive lithium solvation of linear and cyclic carbonates from quantum chemistry.

    PubMed

    Borodin, Oleg; Olguin, Marco; Ganesh, P; Kent, Paul R C; Allen, Joshua L; Henderson, Wesley A

    2016-01-01

    The composition of the lithium cation (Li(+)) solvation shell in mixed linear and cyclic carbonate-based electrolytes has been re-examined using Born-Oppenheimer molecular dynamics (BOMD) as a function of salt concentration and cluster calculations with ethylene carbonate:dimethyl carbonate (EC:DMC)-LiPF6 as a model system. A coordination preference for EC over DMC to a Li(+) was found at low salt concentrations, while a slightly higher preference for DMC over EC was found at high salt concentrations. Analysis of the relative binding energies of the (EC)n(DMC)m-Li(+) and (EC)n(DMC)m-LiPF6 solvates in the gas-phase and for an implicit solvent (as a function of the solvent dielectric constant) indicated that the DMC-containing Li(+) solvates were stabilized relative to (EC4)-Li(+) and (EC)3-LiPF6 by immersing them in the implicit solvent. Such stabilization was more pronounced in the implicit solvents with a high dielectric constant. Results from previous Raman and IR experiments were reanalyzed and reconciled by correcting them for changes of the Raman activities, IR intensities and band shifts for the solvents which occur upon Li(+) coordination. After these correction factors were applied to the results of BOMD simulations, the composition of the Li(+) solvation shell from the BOMD simulations was found to agree well with the solvation numbers extracted from Raman experiments. Finally, the mechanism of the Li(+) diffusion in the dilute (EC:DMC)LiPF6 mixed solvent electrolyte was studied using the BOMD simulations. PMID:26601903

  6. Competitive lithium solvation of linear and cyclic carbonates from quantum chemistry

    SciTech Connect

    Kent, Paul R. C.; Ganesh, Panchapakesan; Borodin, Oleg; Olguin, Marco; Allen, Joshua L.; Henderson, Wesley A.

    2015-11-17

    The composition of the lithium cation (Li+) solvation shell in mixed linear and cyclic carbonate-based electrolytes has been re-examined using Born–Oppenheimer molecular dynamics (BOMD) as a function of salt concentration and cluster calculations with ethylene carbonate:dimethyl carbonate (EC:DMC)–LiPF6 as a model system. A coordination preference for EC over DMC to a Li+ was found at low salt concentrations, while a slightly higher preference for DMC over EC was found at high salt concentrations. Analysis of the relative binding energies of the (EC)n(DMC)m–Li+ and (EC)n(DMC)m–LiPF6 solvates in the gas-phase and for an implicit solvent (as a function of the solvent dielectric constant) indicated that the DMC-containing Li+ solvates were stabilized relative to (EC4)–Li+ and (EC)3–LiPF6 by immersing them in the implicit solvent. Such stabilization was more pronounced in the implicit solvents with a high dielectric constant. Results from previous Raman and IR experiments were reanalyzed and reconciled by correcting them for changes of the Raman activities, IR intensities and band shifts for the solvents which occur upon Li+ coordination. After these correction factors were applied to the results of BOMD simulations, the composition of the Li+ solvation shell from the BOMD simulations was found to agree well with the solvation numbers extracted from Raman experiments. Finally, the mechanism of the Li+ diffusion in the dilute (EC:DMC)LiPF6 mixed solvent electrolyte was studied using the BOMD simulations.

  7. Competitive lithium solvation of linear and cyclic carbonates from quantum chemistry

    DOE PAGESBeta

    Kent, Paul R. C.; Ganesh, Panchapakesan; Borodin, Oleg; Olguin, Marco; Allen, Joshua L.; Henderson, Wesley A.

    2015-11-17

    The composition of the lithium cation (Li+) solvation shell in mixed linear and cyclic carbonate-based electrolytes has been re-examined using Born–Oppenheimer molecular dynamics (BOMD) as a function of salt concentration and cluster calculations with ethylene carbonate:dimethyl carbonate (EC:DMC)–LiPF6 as a model system. A coordination preference for EC over DMC to a Li+ was found at low salt concentrations, while a slightly higher preference for DMC over EC was found at high salt concentrations. Analysis of the relative binding energies of the (EC)n(DMC)m–Li+ and (EC)n(DMC)m–LiPF6 solvates in the gas-phase and for an implicit solvent (as a function of the solvent dielectricmore » constant) indicated that the DMC-containing Li+ solvates were stabilized relative to (EC4)–Li+ and (EC)3–LiPF6 by immersing them in the implicit solvent. Such stabilization was more pronounced in the implicit solvents with a high dielectric constant. Results from previous Raman and IR experiments were reanalyzed and reconciled by correcting them for changes of the Raman activities, IR intensities and band shifts for the solvents which occur upon Li+ coordination. After these correction factors were applied to the results of BOMD simulations, the composition of the Li+ solvation shell from the BOMD simulations was found to agree well with the solvation numbers extracted from Raman experiments. Finally, the mechanism of the Li+ diffusion in the dilute (EC:DMC)LiPF6 mixed solvent electrolyte was studied using the BOMD simulations.« less

  8. Cyclic multiverses

    NASA Astrophysics Data System (ADS)

    Marosek, Konrad; Da¸browski, Mariusz P.; Balcerzak, Adam

    2016-09-01

    Using the idea of regularization of singularities due to the variability of the fundamental constants in cosmology we study the cyclic universe models. We find two models of oscillating and non-singular mass density and pressure (`non-singular' bounce) regularized by varying gravitational constant G despite the scale factor evolution is oscillating and having sharp turning points (`singular' bounce). Both violating (big-bang) and non-violating (phantom) null energy condition models appear. Then, we extend this idea on to the multiverse containing cyclic individual universes with either growing or decreasing entropy though leaving the net entropy constant. In order to get an insight into the key idea, we consider the doubleverse with the same geometrical evolution of the two `parallel' universes with their physical evolution [physical coupling constants c(t) and G(t)] being different. An interesting point is that there is a possibility to exchange the universes at the point of maximum expansion - the fact which was already noticed in quantum cosmology. Similar scenario is also possible within the framework of Brans-Dicke theory where varying G(t) is replaced by the dynamical Brans-Dicke field φ(t) though these theories are slightly different.

  9. A modified non-binary LDPC scheme based on watermark symbols in high speed optical transmission systems

    NASA Astrophysics Data System (ADS)

    Wang, Liming; Qiao, Yaojun; Yu, Qian; Zhang, Wenbo

    2016-04-01

    We introduce a watermark non-binary low-density parity check code (NB-LDPC) scheme, which can estimate the time-varying noise variance by using prior information of watermark symbols, to improve the performance of NB-LDPC codes. And compared with the prior-art counterpart, the watermark scheme can bring about 0.25 dB improvement in net coding gain (NCG) at bit error rate (BER) of 1e-6 and 36.8-81% reduction of the iteration numbers. Obviously, the proposed scheme shows great potential in terms of error correction performance and decoding efficiency.

  10. FPGA implementation of concatenated non-binary QC-LDPC codes for high-speed optical transport.

    PubMed

    Zou, Ding; Djordjevic, Ivan B

    2015-06-01

    In this paper, we propose a soft-decision-based FEC scheme that is the concatenation of a non-binary LDPC code and hard-decision FEC code. The proposed NB-LDPC + RS with overhead of 27.06% provides a superior NCG of 11.9dB at a post-FEC BER of 10-15. As a result, the proposed NB-LDPC codes represent the strong FEC candidate of soft-decision FEC for beyond 100Gb/s optical transmission systems. PMID:26072810

  11. Non-binary coded modulation for FMF-based coherent optical transport networks

    NASA Astrophysics Data System (ADS)

    Lin, Changyu

    The Internet has fundamentally changed the way of modern communication. Current trends indicate that high-capacity demands are not going to be saturated anytime soon. From Shannon's theory, we know that information capacity is a logarithmic function of signal-to-noise ratio (SNR), but a linear function of the number of dimensions. Ideally, we can increase the capacity by increasing the launch power, however, due to the nonlinear characteristics of silica optical fibers that imposes a constraint on the maximum achievable optical-signal-to-noise ratio (OSNR). So there exists a nonlinear capacity limit on the standard single mode fiber (SSMF). In order to satisfy never ending capacity demands, there are several attempts to employ additional degrees of freedom in transmission system, such as few-mode fibers (FMFs), which can dramatically improve the spectral efficiency. On the other hand, for the given physical links and network equipment, an effective solution to relax the OSNR requirement is based on forward error correction (FEC), as the response to the demands of high speed reliable transmission. In this dissertation, we first discuss the model of FMF with nonlinear effects considered. Secondly, we simulate the FMF based OFDM system with various compensation and modulation schemes. Thirdly, we propose tandem-turbo-product nonbinary byte-interleaved coded modulation (BICM) for next-generation high-speed optical transmission systems. Fourthly, we study the Q factor and mutual information as threshold in BICM scheme. Lastly, an experimental study of the limits of nonlinearity compensation with digital signal processing has been conducted.

  12. Evaluation of four-dimensional nonbinary LDPC-coded modulation for next-generation long-haul optical transport networks.

    PubMed

    Zhang, Yequn; Arabaci, Murat; Djordjevic, Ivan B

    2012-04-01

    Leveraging the advanced coherent optical communication technologies, this paper explores the feasibility of using four-dimensional (4D) nonbinary LDPC-coded modulation (4D-NB-LDPC-CM) schemes for long-haul transmission in future optical transport networks. In contrast to our previous works on 4D-NB-LDPC-CM which considered amplified spontaneous emission (ASE) noise as the dominant impairment, this paper undertakes transmission in a more realistic optical fiber transmission environment, taking into account impairments due to dispersion effects, nonlinear phase noise, Kerr nonlinearities, and stimulated Raman scattering in addition to ASE noise. We first reveal the advantages of using 4D modulation formats in LDPC-coded modulation instead of conventional two-dimensional (2D) modulation formats used with polarization-division multiplexing (PDM). Then we demonstrate that 4D LDPC-coded modulation schemes with nonbinary LDPC component codes significantly outperform not only their conventional PDM-2D counterparts but also the corresponding 4D bit-interleaved LDPC-coded modulation (4D-BI-LDPC-CM) schemes, which employ binary LDPC codes as component codes. We also show that the transmission reach improvement offered by the 4D-NB-LDPC-CM over 4D-BI-LDPC-CM increases as the underlying constellation size and hence the spectral efficiency of transmission increases. Our results suggest that 4D-NB-LDPC-CM can be an excellent candidate for long-haul transmission in next-generation optical networks. PMID:22513641

  13. Polarization-multiplexed rate-adaptive non-binary-quasi-cyclic-LDPC-coded multilevel modulation with coherent detection for optical transport networks.

    PubMed

    Arabaci, Murat; Djordjevic, Ivan B; Saunders, Ross; Marcoccia, Roberto M

    2010-02-01

    In order to achieve high-speed transmission over optical transport networks (OTNs) and maximize its throughput, we propose using a rate-adaptive polarization-multiplexed coded multilevel modulation with coherent detection based on component non-binary quasi-cyclic (QC) LDPC codes. Compared to prior-art bit-interleaved LDPC-coded modulation (BI-LDPC-CM) scheme, the proposed non-binary LDPC-coded modulation (NB-LDPC-CM) scheme not only reduces latency due to symbol- instead of bit-level processing but also provides either impressive reduction in computational complexity or striking improvements in coding gain depending on the constellation size. As the paper presents, compared to its prior-art binary counterpart, the proposed NB-LDPC-CM scheme addresses the needs of future OTNs, which are achieving the target BER performance and providing maximum possible throughput both over the entire lifetime of the OTN, better. PMID:20174010

  14. Cryogenic Spectroscopy and Quantum Molecular Dynamics Determine the Structure of Cyclic Intermediates Involved in Peptide Sequence Scrambling.

    PubMed

    Aseev, Oleg; Perez, Marta A S; Rothlisberger, Ursula; Rizzo, Thomas R

    2015-07-01

    Collision-induced dissociation (CID) is a key technique used in mass spectrometry-based peptide sequencing. Collisionally activated peptides undergo statistical dissociation, forming a series of backbone fragment ions that reflect their amino acid (AA) sequence. Some of these fragments may experience a "head-to-tail" cyclization, which after proton migration, can lead to the cyclic structure opening in a different place than the initially formed bond. This process leads to AA sequence scrambling that may hinder sequencing of the initial peptide. Here we combine cryogenic ion spectroscopy and ab initio molecular dynamics simulations to isolate and characterize the precise structures of key intermediates in the scrambling process. The most stable peptide fragments show intriguing symmetric cyclic structures in which the proton is situated on a C2 symmetry axis and forms exceptionally short H-bonds (1.20 Å) with two backbone oxygens. Other nonsymmetric cyclic structures also exist, one of which is protonated on the amide nitrogen, where ring opening is likely to occur. PMID:26266729

  15. Rotational properties of the binary and non-binary populations in the trans-Neptunian belt

    NASA Astrophysics Data System (ADS)

    Thirouin, A.; Noll, K. S.; Ortiz, J. L.; Morales, N.

    2014-09-01

    We present results for the short-term variability of binary trans-Neptunian objects (BTNOs). We performed CCD photometric observations using the 3.58 m Telescopio Nazionale Galileo (TNG), the 1.5 m Sierra Nevada Observatory (OSN) telescope, and the 1.23 m Centro Astronómico Hispano Alemán (CAHA) telescope at Calar Alto Observatory. We present results based on five years of observations and report the short-term variability of six BTNOs. Our sample contains three classical objects: (174567) 2003 MW12, or Varda, (120347) 2004 SB60, or Salacia, and 2002 VT130; one detached disk object: (229762) 2007 UK126; and two resonant objects: (341520) 2007 TY430 and (38628) 2000 EB173, or Huya. For each target, possible rotational periods and/or photometric amplitudes are reported. We also derived some physical properties from their light curves, such as density, primary and secondary sizes, and albedo. We compiled and analyzed a vast light curve database for TNOs including centaurs to determine the light-curve amplitude and spin frequency distributions for the binary and non-binary populations. The mean rotational periods, from the Maxwellian fits to the frequency distributions, are 8.63 ± 0.52 h for the entire sample, 8.37 ± 0.58 h for the sample without the binary population, and 10.11 ± 1.19 h for the binary population alone. Because the centaurs are collisionally more evolved, their rotational periods might not be so primordial. We computed a mean rotational period, from the Maxwellian fit, of 8.86 ± 0.58 h for the sample without the centaur population, and of 8.64 ± 0.67 h considering a sample without the binary and the centaur populations. According to this analysis, regular TNOs spin faster than binaries, which is compatible with the tidal interaction of the binaries. Finally, we examined possible formation models for several systems studied in this work and by our team in previous papers. Appendix A is available in electronic form at http

  16. QSPR models based on molecular mechanics and quantum chemical calculations. 1. Construction of Boltzmann-averaged descriptors for alkanes, alcohols, diols, ethers and cyclic compounds.

    PubMed

    Dyekjaer, Jane; Rasmussen, Kjeld; Jónsdóttir, Svava

    2002-09-01

    Values for nine descriptors for QSPR (quantitative structure-property relationships) modeling of physical properties of 96 alkanes, alcohols, ethers, diols, triols and cyclic alkanes and alcohols in conjunction with the program Codessa are presented. The descriptors are Boltzmann-averaged by selection of the most relevant conformers out of a set of possible molecular conformers generated by a systematic scheme presented in this paper. Six of these descriptors are calculated with molecular mechanics and three with quantum chemical methods. Especially interesting descriptors are the relative van der Waals energies and the molecular polarizabilities, which correlate very well with boiling points. Five more simple descriptors that only depend on the molecular constitutional formula are also discussed briefly. PMID:12415333

  17. On the strong difference in reactivity of acyclic and cyclic diazodiketones with thioketones: experimental results and quantum-chemical interpretation

    PubMed Central

    Mereshchenko, Andrey S; Ivanov, Alexey V; Baranovskii, Viktor I; Rodina, Ludmila L

    2015-01-01

    Summary The 1,3-dipolar cycloaddition of acyclic 2-diazo-1,3-dicarbonyl compounds (DDC) and thioketones preferably occurs with Z,E-conformers and leads to the formation of transient thiocarbonyl ylides in two stages. The thermodynamically favorable further transformation of C=S ylides bearing at least one acyl group is identified as the 1,5-electrocyclization into 1,3-oxathioles. However, in the case of diazomalonates, the dominating process is 1,3-cyclization into thiiranes followed by their spontaneous desulfurization yielding the corresponding alkenes. Finally, carbocyclic diazodiketones are much less reactive under similar conditions due to the locked cyclic structure and are unfavorable for the 1,3-dipolar cycloaddition due to the Z,Z-conformation of the diazo molecule. This structure results in high, positive values of the Gibbs free energy change for the first stage of the cycloaddition process. PMID:25977725

  18. The Oxygen quantum yield in diverse algae and cyanobacteria is controlled by partitioning of flux between linear and cyclic electron flow within photosystem II.

    PubMed

    Ananyev, Gennady; Gates, Colin; Dismukes, G Charles

    2016-09-01

    We have measured flash-induced oxygen quantum yields (O2-QYs) and primary charge separation (Chl variable fluorescence yield, Fv/Fm) in vivo among phylogenetically diverse microalgae and cyanobacteria. Higher O2-QYs can be attained in cells by releasing constraints on charge transfer at the Photosystem II (PSII) acceptor side by adding membrane-permeable benzoquinone (BQ) derivatives that oxidize plastosemiquinone QB(-) and QBH2. This method allows uncoupling PSII turnover from its natural regulation in living cells, without artifacts of isolating PSII complexes. This approach reveals different extents of regulation across species, controlled at the QB(-) acceptor site. Arthrospira maxima is confirmed as the most efficient PSII-WOC (water oxidizing complex) and exhibits the least regulation of flux. Thermosynechococcus elongatus exhibits an O2-QY of 30%, suggesting strong downregulation. WOC cycle simulations with the most accurate model (VZAD) show that a light-driven backward transition (net addition of an electron to the WOC, distinct from recombination) occurs in up to 25% of native PSIIs in the S2 and S3 states, while adding BQ prevents backward transitions and increases the lifetime of S2 and S3 by 10-fold. Backward transitions occur in PSIIs that have plastosemiquinone radicals in the QB site and are postulated to be physiologically regulated pathways for storing light energy as proton gradient through direct PSII-cyclic electron flow (PSII-CEF). PSII-CEF is independent of classical PSI/cyt-b6f-CEF and provides an alternative proton translocation pathway for energy conversion. PSII-CEF enables variable fluxes between linear and cyclic electron pathways, thus accommodating species-dependent needs for redox and ion-gradient energy sources powered by a single photosystem. PMID:27117512

  19. Challenging cisgenderism in the ageing and aged care sector: Meeting the needs of older people of trans and/or non-binary experience.

    PubMed

    Ansara, Y Gavriel

    2015-10-01

    Recent Australian legislative and policy changes can benefit people of trans and/or non-binary experience (e.g. men assigned female with stereotypically 'female' bodies, women assigned male with stereotypically 'male' bodies, and people who identify as genderqueer, agender [having no gender], bi-gender [having two genders] or another gender option). These populations often experience cisgenderism, which previous research defined as 'the ideology that invalidates people's own understanding of their genders and bodies'. Some documented forms of cisgenderism include pathologising (treating people's genders and bodies as disordered) and misgendering (disregarding people's own understanding and classifications of their genders and bodies). This system of classifying people's lived experiences of gender and body invalidation is called the cisgenderism framework. Applying the cisgenderism framework in the ageing and aged care sector can enhance service providers' ability to meet the needs of older people of trans and/or non-binary experience. PMID:26525440

  20. Combined Quantum Chemical/Raman Spectroscopic Analyses of Li+ Cation Solvation: Cyclic Carbonate Solvents - Ethylene Carbonate and Propylene Earbonate

    SciTech Connect

    Allen, Joshua L.; Borodin, Oleg; Seo, D. M.; Henderson, Wesley A.

    2014-12-01

    Combined computational/Raman spectroscopic analyses of ethylene carbonate (EC) and propylene carbonate (PC) solvation interactions with lithium salts are reported. It is proposed that previously reported Raman analyses of (EC)n-LiX mixtures have utilized faulty assumptions. In the present studies, density functional theory (DFT) calculations have provided corrections in terms of both the scaling factors for the solvent's Raman band intensity variations and information about band overlap. By accounting for these factors, the solvation numbers obtained from two different EC solvent bands are in excellent agreement with one another. The same analysis for PC, however, was found to be quite challenging. Commercially available PC is a racemic mixture of (S)- and (R)-PC isomers. Based upon the quantum chemistry calculations, each of these solvent isomers may exist as multiple conformers due to a low energy barrier for ring inversion, making deconvolution of the Raman bands daunting and inherently prone to significant error. Thus, Raman spectroscopy is able to accurately determine the extent of the EC...Li+ cation solvation interactions using the provided methodology, but a similar analysis of PC...Li+ cation solvation results in a significant underestimation of the actual solvation numbers.

  1. Cyclic Voltammetry.

    ERIC Educational Resources Information Center

    Evans, Dennis H.; And Others

    1983-01-01

    Cyclic voltammetry is a simple experiment that has become popular in chemical research because it can provide useful information about redox reactions in a form which is easily obtained and interpreted. Discusses principles of the method and illustrates its use in the study of four electrode reactions. (Author/JN)

  2. Binary versus non-binary information in real time series: empirical results and maximum-entropy matrix models

    NASA Astrophysics Data System (ADS)

    Almog, Assaf; Garlaschelli, Diego

    2014-09-01

    The dynamics of complex systems, from financial markets to the brain, can be monitored in terms of multiple time series of activity of the constituent units, such as stocks or neurons, respectively. While the main focus of time series analysis is on the magnitude of temporal increments, a significant piece of information is encoded into the binary projection (i.e. the sign) of such increments. In this paper we provide further evidence of this by showing strong nonlinear relations between binary and non-binary properties of financial time series. These relations are a novel quantification of the fact that extreme price increments occur more often when most stocks move in the same direction. We then introduce an information-theoretic approach to the analysis of the binary signature of single and multiple time series. Through the definition of maximum-entropy ensembles of binary matrices and their mapping to spin models in statistical physics, we quantify the information encoded into the simplest binary properties of real time series and identify the most informative property given a set of measurements. Our formalism is able to accurately replicate, and mathematically characterize, the observed binary/non-binary relations. We also obtain a phase diagram allowing us to identify, based only on the instantaneous aggregate return of a set of multiple time series, a regime where the so-called ‘market mode’ has an optimal interpretation in terms of collective (endogenous) effects, a regime where it is parsimoniously explained by pure noise, and a regime where it can be regarded as a combination of endogenous and exogenous factors. Our approach allows us to connect spin models, simple stochastic processes, and ensembles of time series inferred from partial information.

  3. Cyclic transformation of orbital angular momentum modes

    NASA Astrophysics Data System (ADS)

    Schlederer, Florian; Krenn, Mario; Fickler, Robert; Malik, Mehul; Zeilinger, Anton

    2016-04-01

    The spatial modes of photons are one realization of a QuDit, a quantum system that is described in a D-dimensional Hilbert space. In order to perform quantum information tasks with QuDits, a general class of D-dimensional unitary transformations is needed. Among these, cyclic transformations are an important special case required in many high-dimensional quantum communication protocols. In this paper, we experimentally demonstrate a cyclic transformation in the high-dimensional space of photonic orbital angular momentum (OAM). Using simple linear optical components, we show a successful four-fold cyclic transformation of OAM modes. Interestingly, our experimental setup was found by a computer algorithm. In addition to the four-cyclic transformation, the algorithm also found extensions to higher-dimensional cycles in a hybrid space of OAM and polarization. Besides being useful for quantum cryptography with QuDits, cyclic transformations are key for the experimental production of high-dimensional maximally entangled Bell-states.

  4. Theoretical design of the cyclic lipopeptide nanotube as a molecular channel in the lipid bilayer, molecular dynamics and quantum mechanics approach.

    PubMed

    Khavani, Mohammad; Izadyar, Mohammad; Housaindokht, Mohammad Reza

    2015-10-14

    In this article, cyclic peptides (CP) with lipid substituents were theoretically designed. The dynamical behavior of the CP dimers and the cyclic peptide nanotube (CPNT) without lipid substituents in the solution (water and chloroform) during the 50 ns molecular dynamic (MD) simulations has been investigated. As a result, the CP dimers and CPNT in a non-polar solvent are more stable than in a polar solvent and CPNT is a good container for non-polar small molecules such as chloroform. The effect of the lipid substituents on the CP dimers and CPNT has been investigated in the next stage of our studies. Accordingly, these substituents increase the stability of the CP dimers and CPNT, significantly, in polar solvents. MM-PBSA and MM-GBSA calculations confirm that substitution has an important effect on the stability of the CP dimers and CPNT. Finally, the dynamical behavior of CPNT with lipid substituents in a fully hydrated DMPC bilayer shows the high ability of this structure for molecule transmission across the lipid membrane. This structure is stable enough to be used as a molecular channel. DFT calculations on the CP dimers in the gas phase, water and chloroform, indicate that H-bond formation is the driving force for dimerization. CP dimers are more stable in the gas phase in comparison to in solution. HOMO-LUMO orbital analysis indicates that the interaction of the CP units in the dimer structures is due to the molecular orbital interactions between the NH and CO groups. PMID:26366633

  5. General solution of the cyclic Leibniz rule

    NASA Astrophysics Data System (ADS)

    Kadoh, Daisuke; Ukita, Naoya

    2015-10-01

    We study the cyclic Leibniz rule (CLR) which was recently proposed as a new approach to the realization of supersymmetric quantum mechanics on the lattice. The CLR has an infinite number of solutions that give the different definitions of the lattice supersymmetric quantum mechanics. We show the general form of the solution for the naive symmetric difference operator and reveal the differences between the lattice models.

  6. Scale invariant density perturbations from cyclic cosmology

    NASA Astrophysics Data System (ADS)

    Frampton, Paul Howard

    2016-04-01

    It is shown how quantum fluctuations of the radiation during the contraction era of a comes back empty (CBE) cyclic cosmology can provide density fluctuations which re-enter the horizon during the subsequent expansion era and at lowest order are scale invariant, in a Harrison-Zel’dovich-Peebles sense. It is necessary to be consistent with observations of large scale structure.

  7. Plant Cyclic Nucleotide Signalling

    PubMed Central

    Martinez-Atienza, Juliana; Van Ingelgem, Carl; Roef, Luc

    2007-01-01

    The presence of the cyclic nucleotides 3′,5′-cyclic adenyl monophosphate (cAMP) and 3′,5′-cyclic guanyl monophosphate (cGMP) in plants is now generally accepted. In addition, cAMP and cGMP have been implicated in the regulation of important plant processes such as stomatal functioning, monovalent and divalent cation fluxes, chloroplast development, gibberellic acid signalling, pathogen response and gene transcription. However, very little is known regarding the components of cyclic nucleotide signalling in plants. In this addendum, the evidence for specific mechanisms of plant cyclic nucleotide signalling is evaluated and discussed. PMID:19704553

  8. Cyclic phosphonium ionic liquids

    PubMed Central

    Mukhlall, Joshua A; Romeo, Alicia R; Gohdo, Masao; Ramati, Sharon; Berman, Marc; Suarez, Sophia N

    2014-01-01

    Summary Ionic liquids (ILs) incorporating cyclic phosphonium cations are a novel category of materials. We report here on the synthesis and characterization of four new cyclic phosphonium bis(trifluoromethylsulfonyl)amide ILs with aliphatic and aromatic pendant groups. In addition to the syntheses of these novel materials, we report on a comparison of their properties with their ammonium congeners. These exemplars are slightly less conductive and have slightly smaller self-diffusion coefficients than their cyclic ammonium congeners. PMID:24605146

  9. Are Math Grades Cyclical?

    ERIC Educational Resources Information Center

    Adams, Gerald J.; Dial, Micah

    1998-01-01

    The cyclical nature of mathematics grades was studied for a cohort of elementary school students from a large metropolitan school district in Texas over six years (average cohort size of 8495). The study used an autoregressive integrated moving average (ARIMA) model. Results indicate that grades do exhibit a significant cyclical pattern. (SLD)

  10. Affordable Cyclic Voltammetry

    ERIC Educational Resources Information Center

    Stewart, Greg; Kuntzleman, Thomas S.; Amend, John R.; Collins, Michael J.

    2009-01-01

    Cyclic voltammetry is an important component of the undergraduate chemical curriculum. Unfortunately, undergraduate students rarely have the opportunity to conduct experiments in cyclic voltammetry owing to the high cost of potentiostats, which are required to control these experiments. By using MicroLab data acquisition interfaces in conjunction…

  11. Genetics Home Reference: cyclic neutropenia

    MedlinePlus

    ... Understand Genetics Home Health Conditions cyclic neutropenia cyclic neutropenia Enable Javascript to view the expand/collapse boxes. Download PDF Open All Close All Description Cyclic neutropenia is a disorder that causes frequent infections and ...

  12. Cyclic control stick

    DOEpatents

    Whitaker, Charles N.; Zimmermann, Richard E.

    1989-01-01

    A cyclic control stick of the type used in helicopters for reducing the safety hazards associated with such a mechanism in the event of a crewman being thrown violently into contact with the cyclic control stick resulting from a crash or the like. The cyclic control stick is configured to break away upon the exertion of an impact force which exceeds a predetermined value and/or is exerted for more than a momentary time duration. The cyclic control stick is also configured to be adjustable so as to locate the grip thereof as far away from the crewman as possible for safety reasons without comprising the comfort of the crewman or the use of the control stick, and a crushable pad is provided on the top of the grip for impact energy absorbing purposes.

  13. Cyclic steps on ice

    NASA Astrophysics Data System (ADS)

    Yokokawa, M.; Izumi, N.; Naito, K.; Parker, G.; Yamada, T.; Greve, R.

    2016-05-01

    Boundary waves often form at the interface between ice and fluid flowing adjacent to it, such as ripples under river ice covers, and steps on the bed of supraglacial meltwater channels. They may also be formed by wind, such as the megadunes on the Antarctic ice sheet. Spiral troughs on the polar ice caps of Mars have been interpreted to be cyclic steps formed by katabatic wind blowing over ice. Cyclic steps are relatives of upstream-migrating antidunes. Cyclic step formation on ice is not only a mechanical but also a thermodynamic process. There have been very few studies on the formation of either cyclic steps or upstream-migrating antidunes on ice. In this study, we performed flume experiments to reproduce cyclic steps on ice by flowing water, and found that trains of steps form when the Froude number is larger than unity. The features of those steps allow them to be identified as ice-bed analogs of cyclic steps in alluvial and bedrock rivers. We performed a linear stability analysis and obtained a physical explanation of the formation of upstream-migrating antidunes, i.e., precursors of cyclic steps. We compared the results of experiments with the predictions of the analysis and found the observed steps fall in the range where the analysis predicts interfacial instability. We also found that short antidune-like undulations formed as a precursor to the appearance of well-defined steps. This fact suggests that such antidune-like undulations correspond to the instability predicted by the analysis and are precursors of cyclic steps.

  14. Cyclic polymers from alkynes.

    PubMed

    Roland, Christopher D; Li, Hong; Abboud, Khalil A; Wagener, Kenneth B; Veige, Adam S

    2016-08-01

    Cyclic polymers have dramatically different physical properties compared with those of their equivalent linear counterparts. However, the exploration of cyclic polymers is limited because of the inherent challenges associated with their synthesis. Conjugated linear polyacetylenes are important materials for electrical conductivity, paramagnetic susceptibility, optical nonlinearity, photoconductivity, gas permeability, liquid crystallinity and chain helicity. However, their cyclic analogues are unknown, and therefore the ability to examine how a cyclic topology influences their properties is currently not possible. We have solved this challenge and now report a tungsten catalyst supported by a tetraanionic pincer ligand that can rapidly polymerize alkynes to form conjugated macrocycles in high yield. The catalyst works by tethering the ends of the polymer to the metal centre to overcome the inherent entropic penalty of cyclization. Gel-permeation chromatography, dynamic and static light scattering, viscometry and chemical tests are all consistent with theoretical predictions and provide unambiguous confirmation of a cyclic topology. Access to a wide variety of new cyclic polymers is now possible by simply choosing the appropriate alkyne monomer. PMID:27442285

  15. Cyclic polymers from alkynes

    NASA Astrophysics Data System (ADS)

    Roland, Christopher D.; Li, Hong; Abboud, Khalil A.; Wagener, Kenneth B.; Veige, Adam S.

    2016-08-01

    Cyclic polymers have dramatically different physical properties compared with those of their equivalent linear counterparts. However, the exploration of cyclic polymers is limited because of the inherent challenges associated with their synthesis. Conjugated linear polyacetylenes are important materials for electrical conductivity, paramagnetic susceptibility, optical nonlinearity, photoconductivity, gas permeability, liquid crystallinity and chain helicity. However, their cyclic analogues are unknown, and therefore the ability to examine how a cyclic topology influences their properties is currently not possible. We have solved this challenge and now report a tungsten catalyst supported by a tetraanionic pincer ligand that can rapidly polymerize alkynes to form conjugated macrocycles in high yield. The catalyst works by tethering the ends of the polymer to the metal centre to overcome the inherent entropic penalty of cyclization. Gel-permeation chromatography, dynamic and static light scattering, viscometry and chemical tests are all consistent with theoretical predictions and provide unambiguous confirmation of a cyclic topology. Access to a wide variety of new cyclic polymers is now possible by simply choosing the appropriate alkyne monomer.

  16. [Cyclic enteral nutrition].

    PubMed

    Hébuterne, X; Rampal, P

    1996-02-10

    Cyclic enteral nutrition consists in continuous infusion of nutrients with a pump over a 12 to 14 hour period at night. Different reports have demonstrated that cyclic enteral nutrition is well tolerated in malnourished ambulatory patients. The incidence of pneumonia by inhalation in this type of patients is less than 2%. Excepting patients with major amputation of the small intestine and important functional consequences, the increased infusion rate required by cyclic enteral nutrition does not diminish digestive tract absorption making the technique as effective as continuous 24-hour infusion. The main advantages of the cyclic infusion are the preservation of physiological balance between fasting and feeding, improved physical activity during the day with its beneficial effect on protein-energy metabolism, compatibility with oral nutrition during the day in nutrition reeducation programs, and the psychological impact in patients who are free to move about, further improving tolerance. Finally, cyclic enteral nutrition is adapted to enteral nutrition programs conducted in the patient's homes. PMID:8729381

  17. Cyclic membrane separation process

    DOEpatents

    Bowser, John

    2004-04-13

    A cyclic process for controlling environmental emissions of volatile organic compounds (VOC) from vapor recovery in storage and dispensing operations of liquids maintains a vacuum in the storage tank ullage. In one of a two-part cyclic process ullage vapor is discharged through a vapor recovery system in which VOC are stripped from vented gas with a selectively gas permeable membrane. In the other part, the membrane is inoperative while gas pressure rises in the ullage. Ambient air is charged to the membrane separation unit during the latter part of the cycle.

  18. Flow in cyclic cosmology

    SciTech Connect

    Kinney, William H.; Dizgah, Azadeh Moradinezhad

    2010-10-15

    In this paper, we use a known duality between expanding and contracting cosmologies to construct a dual of the inflationary flow hierarchy applicable to contracting cosmologies such as ekpyrotic and cyclic models. We show that the inflationary flow equations are invariant under the duality and therefore apply equally well to inflation or to cyclic cosmology. We construct a self-consistent small-parameter approximation dual to the slow-roll approximation in inflation, and calculate the power spectrum of perturbations in this limit. We also recover the matter-dominated contracting solution of Wands, and the recently proposed adiabatic ekpyrosis solution.

  19. Cyclic membrane separation process

    DOEpatents

    Nemser, Stuart M.

    2005-05-03

    A cyclic process for controlling environmental emissions of volatile organic compounds (VOC) from vapor recovery in storage and dispensing operations of liquids maintains a vacuum in the storage tank ullage. In the first part of a two-part cyclic process ullage vapor is discharged through a vapor recovery system in which VOC are stripped from vented gas with a selectively gas permeable membrane. In the second part, the membrane is inoperative while gas pressure rises in the ullage. In one aspect of this invention, a vacuum is drawn in the membrane separation unit thus reducing overall VOC emissions.

  20. Long distance quantum communication using quantum error correction

    NASA Technical Reports Server (NTRS)

    Gingrich, R. M.; Lee, H.; Dowling, J. P.

    2004-01-01

    We describe a quantum error correction scheme that can increase the effective absorption length of the communication channel. This device can play the role of a quantum transponder when placed in series, or a cyclic quantum memory when inserted in an optical loop.

  1. Cyclic Voltammetry Experiment.

    ERIC Educational Resources Information Center

    Van Benschoten, James J.; And Others

    1983-01-01

    Describes a three-part experiment designed to introduce cyclic voltammetry to graduate/undergraduate students. Part 1 demonstrates formal reduction potential, redox electron transfer, diffusion coefficient, and electrochemical reversibility. Part 2 investigates electrochemical behavior of acetaminophen. Part 3 examines such experimental variables…

  2. Intercalation of cyclic ketones into vanadyl phosphate

    SciTech Connect

    Zima, Vitezslav . E-mail: vitezslav.zima@upce.cz; Melanova, Klara; Benes, Ludvik; Trchova, Miroslava; Dybal, Jiri

    2005-01-15

    Intercalation compounds of vanadyl phosphate with cyclic ketones (cyclopentanone, cyclohexanone, 4-methylcyclohexanone, and 1,4-cyclohexanedione) were prepared from corresponding propanol or ethanol intercalates by a molecular exchange. The intercalates prepared were characterized using powder X-ray diffraction and thermogravimetric analysis. The intercalates are stable in dry environment and decompose slowly in humid air. Infrared and Raman spectra indicate that carbonyl oxygens of the guest molecules are coordinated to the vanadium atoms of the host layers. The local structure and interactions in the cyclopentanone intercalate have been suggested on the basis of quantum chemical calculations.

  3. Cosmic perturbations through the cyclic ages

    SciTech Connect

    Erickson, Joel K.; Gratton, Steven; Steinhardt, Paul J.; Turok, Neil

    2007-06-15

    We analyze the evolution of cosmological perturbations in the cyclic model, paying particular attention to their behavior and interplay over multiple cycles. Our key results are: (1) galaxies and large scale structure present in one cycle are generated by the quantum fluctuations in the preceding cycle without interference from perturbations or structure generated in earlier cycles and without interfering with structure generated in later cycles; (2) the ekpyrotic phase, an epoch of gentle contraction with equation of state w>>1 preceding the hot big bang, makes the universe homogeneous, isotropic and flat within any given observer's horizon; and (3) although the universe is uniform within each observer's horizon, the structure of the cyclic universe on very large scales is more complex, owing to the effects of superhorizon length perturbations, and cannot be described globally as a Friedmann-Robertson-Walker cosmology. In particular, we show that the ekpyrotic contraction phase is so effective in smoothing, flattening and isotropizing the universe within the horizon that this phase alone suffices to solve the horizon and flatness problems even without an extended period of dark energy domination (a kind of low energy inflation). Instead, the cyclic model rests on a genuinely novel, noninflationary mechanism (ekpyrotic contraction) for resolving the classic cosmological conundrums.

  4. An Early Cyclic Universe

    NASA Astrophysics Data System (ADS)

    Duhe, William; Biswas, Tirthibir

    2014-03-01

    We provide a comprehensive numerical study of the Emergent Cyclic Inflation scenario. This is a scenario where instead of traditional monotonic slow roll inflation, the universe expands over numerous short asymmetric cycles due to the production of entropy via interactions among different species. This is one of the very few scenarios of inflation which provides a nonsingular geodesically complete space-time and does not require any ``reheating'' mechanism. A special thanks to Loyola University for an excellent community to help this project grow.

  5. Geometric phases and cyclic isotropic cosmologies

    NASA Astrophysics Data System (ADS)

    Banchi, Leonardo; Caravelli, Francesco

    2016-05-01

    In the present paper we study the evolution of the modes of a scalar field in a cyclic cosmology. In order to keep the discussion clear, we study the features of a scalar field in a toy model, a Friedman-Robertson-Walker Universe with a periodic scale factor, in which the Universe expands, contracts and bounces infinite times, in the approximation in which the dynamic features of this Universe are driven by some external factor, without the backreaction of the scalar field under study. In particular, we show that particle production exhibits features of the cyclic cosmology. Also, by studying the Berry phase of the scalar field, we show that contrary to what is commonly believed, the scalar field carries information from one bounce to another in the form of a global phase which occurs as generically non-zero. The Berry phase is then evaluated numerically in the case of the effective loop quantum cosmology closed Universe. We observe that Berry’s phase is non-zero, but that in the quantum regime the particle content is non-negligible.

  6. Ada and cyclic runtime scheduling

    NASA Technical Reports Server (NTRS)

    Hood, Philip E.

    1986-01-01

    An important issue that must be faced while introducing Ada into the real time world is efficient and prodictable runtime behavior. One of the most effective methods employed during the traditional design of a real time system is the cyclic executive. The role cyclic scheduling might play in an Ada application in terms of currently available implementations and in terms of implementations that might be developed especially to support real time system development is examined. The cyclic executive solves many of the problems faced by real time designers, resulting in a system for which it is relatively easy to achieve approporiate timing behavior. Unfortunately a cyclic executive carries with it a very high maintenance penalty over the lifetime of the software that is schedules. Additionally, these cyclic systems tend to be quite fragil when any aspect of the system changes. The findings are presented of an ongoing SofTech investigation into Ada methods for real time system development. The topics covered include a description of the costs involved in using cyclic schedulers, the sources of these costs, and measures for future systems to avoid these costs without giving up the runtime performance of a cyclic system.

  7. Cyclic AMP in prokaryotes.

    PubMed Central

    Botsford, J L; Harman, J G

    1992-01-01

    Cyclic AMP (cAMP) is found in a variety of prokaryotes including both eubacteria and archaebacteria. cAMP plays a role in regulating gene expression, not only for the classic inducible catabolic operons, but also for other categories. In the enteric coliforms, the effects of cAMP on gene expression are mediated through its interaction with and allosteric modification of a cAMP-binding protein (CRP). The CRP-cAMP complex subsequently binds specific DNA sequences and either activates or inhibits transcription depending upon the positioning of the complex relative to the promoter. Enteric coliforms have provided a model to explore the mechanisms involved in controlling adenylate cyclase activity, in regulating adenylate cyclase synthesis, and in performing detailed examinations of CRP-cAMP complex-regulated gene expression. This review summarizes recent work focused on elucidating the molecular mechanisms of CRP-cAMP complex-mediated processes. For other bacteria, less detail is known. cAMP has been implicated in regulating antibiotic production, phototrophic growth, and pathogenesis. A role for cAMP has been suggested in nitrogen fixation. Often the only data that support cAMP involvement in these processes includes cAMP measurement, detection of the enzymes involved in cAMP metabolism, or observed effects of high concentrations of the nucleotide on cell growth. PMID:1315922

  8. Cyclic Vomiting Syndrome

    PubMed Central

    2009-01-01

    Initially described in children, cyclic vomiting syndrome (CVS) is an idiopathic disorder that affects patients of all ages and is characterized by recurrent episodes of vomiting separated by symptom-free intervals or baseline health. Frequent misdiagnoses and delays in diagnosis often lead to years of recurrent vomiting. Similarities in the clinical features and symptoms of children and adults with CVS are often linked to migraines. Association with mitochondrial disorders and neuroendocrine dysfunction have been described in the pediatric CVS literature, whereas migraines, anxiety, and panic are common in adults with CVS. Various psychological, infectious, and physical stressors commonly precipitate episodes of CVS. Treatment is mostly empiric, with few controlled therapeutic studies conducted thus far. Associations with migraines have aided in developing pharmacologic treatment strategies for prophylaxis as well as abortive therapy during episodes, including the use of trip-tans. Most children outgrow CVS with time, though some children transition to migraine headaches or continue to have CVS as adults. Improved recognition of CVS in adults, along with the emergence of data in the use of anticonvulsants and antiemetics, may help further delineate pathophysiologic connections and therapeutic options for this debilitating disorder.

  9. Quantum image coding with a reference-frame-independent scheme

    NASA Astrophysics Data System (ADS)

    Chapeau-Blondeau, François; Belin, Etienne

    2016-07-01

    For binary images, or bit planes of non-binary images, we investigate the possibility of a quantum coding decodable by a receiver in the absence of reference frames shared with the emitter. Direct image coding with one qubit per pixel and non-aligned frames leads to decoding errors equivalent to a quantum bit-flip noise increasing with the misalignment. We show the feasibility of frame-invariant coding by using for each pixel a qubit pair prepared in one of two controlled entangled states. With just one common axis shared between the emitter and receiver, exact decoding for each pixel can be obtained by means of two two-outcome projective measurements operating separately on each qubit of the pair. With strictly no alignment information between the emitter and receiver, exact decoding can be obtained by means of a two-outcome projective measurement operating jointly on the qubit pair. In addition, the frame-invariant coding is shown much more resistant to quantum bit-flip noise compared to the direct non-invariant coding. For a cost per pixel of two (entangled) qubits instead of one, complete frame-invariant image coding and enhanced noise resistance are thus obtained.

  10. Quantum image coding with a reference-frame-independent scheme

    NASA Astrophysics Data System (ADS)

    Chapeau-Blondeau, François; Belin, Etienne

    2016-04-01

    For binary images, or bit planes of non-binary images, we investigate the possibility of a quantum coding decodable by a receiver in the absence of reference frames shared with the emitter. Direct image coding with one qubit per pixel and non-aligned frames leads to decoding errors equivalent to a quantum bit-flip noise increasing with the misalignment. We show the feasibility of frame-invariant coding by using for each pixel a qubit pair prepared in one of two controlled entangled states. With just one common axis shared between the emitter and receiver, exact decoding for each pixel can be obtained by means of two two-outcome projective measurements operating separately on each qubit of the pair. With strictly no alignment information between the emitter and receiver, exact decoding can be obtained by means of a two-outcome projective measurement operating jointly on the qubit pair. In addition, the frame-invariant coding is shown much more resistant to quantum bit-flip noise compared to the direct non-invariant coding. For a cost per pixel of two (entangled) qubits instead of one, complete frame-invariant image coding and enhanced noise resistance are thus obtained.

  11. On Improvements of Cyclic MUSIC

    NASA Astrophysics Data System (ADS)

    Yan, Huiqin; Fan, H. Howard

    2005-12-01

    Many man-made signals encountered in communications exhibit cyclostationarity. By exploiting cyclostationarity, cyclic MUSIC has been shown to be able to separate signals with different cycle frequencies, thus, to be able to perform signal selective direction of-arrival (DOA) estimation. However, as will be shown in this paper, the DOA estimation of cyclic MUSIC is actually biased. We show in this paper that by properly choosing the frequency for evaluating the steering vector, the bias of DOA estimation can be substantially reduced and the performance can be improved. Furthermore, we propose another algorithm exploiting cyclic conjugate correlation to further improve the performance of DOA estimation. Simulation results show the effectiveness of both of our methods.

  12. Cyclical magnetic field flow fractionation

    NASA Astrophysics Data System (ADS)

    Tasci, T. O.; Johnson, W. P.; Gale, B. K.

    2012-04-01

    In this study, a new magnetic field flow fractionation (FFF) system was designed and modeled by using finite element simulations. Other than current magnetic FFF systems, which use static magnetic fields, our system uses cyclical magnetic fields. Results of the simulations show that our cyclical magnetic FFF system can be used effectively for the separation of magnetic nanoparticles. Cyclical magnetic FFF system is composed of a microfluidic channel (length = 5 cm, height = 30 μm) and 2 coils. Square wave currents of 1 Hz (with 90 deg of phase difference) were applied to the coils. By using Comsol Multiphysics 3.5a, magnetic field profile and corresponding magnetic force exerted on the magnetite nanoparticles were calculated. The magnetic force data were exported from Comsol to Matlab. In Matlab, a parabolic flow profile with maximum flow speed of 0.4 mL/h was defined. Particle trajectories were obtained by the calculation of the particle speeds resulted from both magnetic and hydrodynamic forces. Particle trajectories of the particles with sizes ranging from 10 to 50 nm were simulated and elution times of the particles were calculated. Results show that there is a significant difference between the elution times of the particles so that baseline separation of the particles can be obtained. In this work, it is shown that by the application of cyclical magnetic fields, the separation of magnetic nanoparticles can be done efficiently.

  13. Buffering in cyclic gene networks

    NASA Astrophysics Data System (ADS)

    Glyzin, S. D.; Kolesov, A. Yu.; Rozov, N. Kh.

    2016-06-01

    We consider cyclic chains of unidirectionally coupled delay differential-difference equations that are mathematical models of artificial oscillating gene networks. We establish that the buffering phenomenon is realized in these system for an appropriate choice of the parameters: any given finite number of stable periodic motions of a special type, the so-called traveling waves, coexist.

  14. Color visualization of cyclic magnitudes

    NASA Astrophysics Data System (ADS)

    Restrepo, Alfredo; Estupiñán, Viviana

    2014-02-01

    We exploit the perceptual, circular ordering of the hues in a technique for the visualization of cyclic variables. The hue is thus meaningfully used for the indication of variables such as the azimuth and the units of the measurement of time. The cyclic (or circular) variables may be both of the continuous type or the discrete type; among the first there is azimuth and among the last you find the musical notes and the days of the week. A correspondence between the values of a cyclic variable and the chromatic hues, where the natural circular ordering of the variable is respected, is called a color code for the variable. We base such a choice of hues on an assignment of of the unique hues red, yellow, green and blue, or one of the 8 even permutations of this ordered list, to 4 cardinal values of the cyclic variable, suitably ordered; color codes based on only 3 cardinal points are also possible. Color codes, being intuitive, are easy to remember. A possible low accuracy when reading instruments that use this technique is compensated by fast, ludic and intuitive readings; also, the use of a referential frame makes readings precise. An achromatic version of the technique, that can be used by dichromatic people, is proposed.

  15. Can cyclic HIV protease inhibitors bind in a non-preferred form? An ab initio, DFT and MM-PB(GB)SA study.

    PubMed

    Oehme, Daniel P; Brownlee, Robert T C; Wilson, David J D

    2013-03-01

    X-ray crystallography studies have identified that most cyclic inhibitors of HIV protease (including cyclic ureas) bind in a symmetric manner, however some cyclic inhibitors, such as cyclic sulfamides, bind in a non-symmetric manner. This raises the question as to whether it is possible for cyclic sulfamides to bind symmetrically and conversely for cyclic ureas to bind non-symmetrically. Herein we report an analysis of the conformational preference of cyclic ureas and sulfamides both free in solution and bound to HIV protease, including an investigation of the effect of branching. Quantum chemical calculations (B3LYP, M06-2X, MP2, CCSD(T)) predict the cyclic urea to prefer a symmetric conformation in solution, with a large activation barrier towards inter-conversion to the non-symmetric conformation. This differs from the cyclic sulfamides, which marginally prefer a non-symmetric conformation with a much smaller barrier to inter-conversion making it more likely for a non-preferred conformation to be observed. It is predicted that the cyclic scaffold itself favours a symmetric form, while branching induces a preference for a non-symmetric form. MD simulations on the free inhibitors identified inter-conversion with the cyclic sulfamides but not the cyclic ureas, in support of the quantum chemical results. MM-PB(GB)SA calculations on the cyclic inhibitors bound to HIV protease corroborate the X-ray crystallography studies, identifying the cyclic ureas to bind symmetrically and the cyclic sulfamides in a non-symmetrical manner. While the non-preferred form of the sulfamide may well be present as a free molecule in solution, our results suggest that it is unlikely to bind to HIV protease in a symmetric manner. PMID:23149763

  16. Modulators of cyclic AMP systems.

    PubMed

    Hess, S M; Chasin, M; Free, C A; Harris, D N

    1975-01-01

    On the basis of the data reported here, one may conclude that although many agents that act in the central nervous system are modulators of the action of cyclic AMP, it is difficult to establish a direct connection between the pharmacologic activity and the levels of cyclic AMP in the brain. This lack of interrelation applies to the benzodiazepines as well as to the pyrazolopyridines. The data for members of the latter group are somewhat frustrating in this regard, since an excellent correlation has been shown to exist between the potency of inhibition of PDE and activity in the antianxiety test. In measurements of steroidogenesis in the isolated adrenal cell, the correlation between activity in vito and the conflict assay is even better. The data presented here and reported elsewhere (Shimizu et al., 1974; Kelly et al., 1974; Mayer and King, 1974; King and Mayer, 1974) provide evidence that agents that act as inhibitors of PDE in cell-free systems exert their influence on cyclic AMP in tissue slices of the brain of guinea pigs by mechanisms that seem not to be related to an effect on PDE. Papaverine, and possibly chlordiazepoxide, may act by releasing agonists that, in turn, stimulate the accumulation of cyclic AMP. This activity is blocked bo other inhibitors of PDE, such as theophyline. Results obtained by the use of platelets are refreshingly clear. Inhibition of aggregation has been shown to occur when the level of cyclic AMP is raised, and a suggestive exists that the most potent inhibitors of platelet PDE are the best potentiators of the action of PGE1 in blocking aggregation. The study utilizing drugs collected from a large number of therapeutic classes makes clear that it is difficult to attribute the mechanism of action for any of the classes studied to modulation of cyclic AMP. An unexpected finding of this study, however, was the fact that pharmacologic agents include an unusually large number of inhibitors of PDE as compared with agents chosen at

  17. Supramolecular nesting of cyclic polymers

    NASA Astrophysics Data System (ADS)

    Kondratuk, Dmitry V.; Perdigão, Luís M. A.; Esmail, Ayad M. S.; O'Shea, James N.; Beton, Peter H.; Anderson, Harry L.

    2015-04-01

    Advances in template-directed synthesis make it possible to create artificial molecules with protein-like dimensions, directly from simple components. These synthetic macromolecules have a proclivity for self-organization that is reminiscent of biopolymers. Here, we report the synthesis of monodisperse cyclic porphyrin polymers, with diameters of up to 21 nm (750 C-C bonds). The ratio of the intrinsic viscosities for cyclic and linear topologies is 0.72, indicating that these polymers behave as almost ideal flexible chains in solution. When deposited on gold surfaces, the cyclic polymers display a new mode of two-dimensional supramolecular organization, combining encapsulation and nesting; one nanoring adopts a near-circular conformation, thus allowing a second nanoring to be captured within its perimeter, in a tightly folded conformation. Scanning tunnelling microscopy reveals that nesting occurs in combination with stacking when nanorings are deposited under vacuum, whereas when they are deposited directly from solution under ambient conditions there is stacking or nesting, but not a combination of both.

  18. Quantum Computation and Quantum Information

    NASA Astrophysics Data System (ADS)

    Nielsen, Michael A.; Chuang, Isaac L.

    2010-12-01

    Part I. Fundamental Concepts: 1. Introduction and overview; 2. Introduction to quantum mechanics; 3. Introduction to computer science; Part II. Quantum Computation: 4. Quantum circuits; 5. The quantum Fourier transform and its application; 6. Quantum search algorithms; 7. Quantum computers: physical realization; Part III. Quantum Information: 8. Quantum noise and quantum operations; 9. Distance measures for quantum information; 10. Quantum error-correction; 11. Entropy and information; 12. Quantum information theory; Appendices; References; Index.

  19. Cyclic GMP and Cilia Motility

    PubMed Central

    Wyatt, Todd A.

    2015-01-01

    Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-monophosphate (cGMP). In this review, the history of cGMP action is presented and a survey of the existing data addressing cGMP action in ciliary motility is presented. Nitric oxide (NO)-mediated regulation of cGMP in ciliated cells is presented in the context of alcohol-induced cilia function and dysfunction. PMID:26264028

  20. Fitting curves to cyclic data

    USGS Publications Warehouse

    Langbein, W.B.

    1955-01-01

    A common problem in hydrology is to fit a smooth curve to cyclic or periodic data, either to define the most probable values of the data or to test some principle that one wishes to demonstrate.  This study treats of those problems where the length or period of the cycle is know beforehand - as a day, year, or meander length for example.  Curve-fitting can be made by free-hand drawing, and where the data are closely aligned this method offers the simplest and most direct course.  However, there are many problems where the best fit is far from obvious, and analytical methods may be necessary.

  1. Insights into How Cyclic Peptides Switch Conformations.

    PubMed

    McHugh, Sean M; Rogers, Julia R; Yu, Hongtao; Lin, Yu-Shan

    2016-05-10

    Cyclic peptides have recently emerged as promising modulators of protein-protein interactions. However, it is currently highly difficult to predict the structures of cyclic peptides owing to their rugged conformational free energy landscape, which prevents sampling of all thermodynamically relevant conformations. In this article, we first investigate how a relatively flexible cyclic hexapeptide switches conformations. It is found that, although the circular geometry of small cyclic peptides of size 6-8 may require rare, coherent dihedral changes to sample a new conformation, the changes are rather local, involving simultaneous changes of ϕi and ψi or ψi and ϕi+1. The understanding of how these cyclic peptides switch conformations enables the use of metadynamics simulations with reaction coordinates specifically targeting such coupled two-dihedral changes to effectively sample cyclic peptide conformational space. PMID:27031286

  2. Advances in targeting cyclic nucleotide phosphodiesterases

    PubMed Central

    Maurice, Donald H.; Ke, Hengming; Ahmad, Faiyaz; Wang, Yousheng; Chung, Jay; Manganiello, Vincent C.

    2014-01-01

    Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signalling pathways and, consequently, myriad biological responses in health and disease. Currently, a small number of PDE inhibitors are used clinically for treating the pathophysiological dysregulation of cyclic nucleotide signalling in several disorders, including erectile dysfunction, pulmonary hypertension, acute refractory cardiac failure, intermittent claudication and chronic obstructive pulmonary disease. However, pharmaceutical interest in PDEs has been reignited by the increasing understanding of the roles of individual PDEs in regulating the subcellular compartmentalization of specific cyclic nucleotide signalling pathways, by the structure-based design of novel specific inhibitors and by the development of more sophisticated strategies to target individual PDE variants. PMID:24687066

  3. Advances in targeting cyclic nucleotide phosphodiesterases.

    PubMed

    Maurice, Donald H; Ke, Hengming; Ahmad, Faiyaz; Wang, Yousheng; Chung, Jay; Manganiello, Vincent C

    2014-04-01

    Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signalling pathways and, consequently, myriad biological responses in health and disease. Currently, a small number of PDE inhibitors are used clinically for treating the pathophysiological dysregulation of cyclic nucleotide signalling in several disorders, including erectile dysfunction, pulmonary hypertension, acute refractory cardiac failure, intermittent claudication and chronic obstructive pulmonary disease. However, pharmaceutical interest in PDEs has been reignited by the increasing understanding of the roles of individual PDEs in regulating the subcellular compartmentalization of specific cyclic nucleotide signalling pathways, by the structure-based design of novel specific inhibitors and by the development of more sophisticated strategies to target individual PDE variants. PMID:24687066

  4. Cyclic Imide Dioxime: Formation and Hydrolytic Stability

    SciTech Connect

    Kang, S.O.; Vukovic, Sinisa; Custelcean, Radu; Hay, Benjamin

    2012-01-01

    Poly(acrylamidoximes) play an important role in the uranium extraction from seawater. The present work reports solution studies of simple analogs to address the formation and stability of two binding sites present in these polymers, open-chain amidoximes and cyclic imide dioximes, including: 1) conditions that maximize the formation of the cyclic form, 2) existence of a base-induced conversion from open-chain to cyclic form, and 3) degradation under acid and base conditions.

  5. Cyclic strength of hard metals

    SciTech Connect

    Sereda, N.N.; Gerikhanov, A.K.; Koval'chenko, M.S.; Pedanov, L.G.; Tsyban', V.A.

    1986-02-01

    The authors study the strength of hard-metal specimens and structural elements under conditions of cyclic loading since many elements of processing plants, equipment, and machines are made of hard metals. Fatigue tests were conducted on KTS-1N, KTSL-1, and KTNKh-70 materials, which are titanium carbide hard metals cemented with nickel-molybdenum, nickelcobalt-chromium, and nickel-chromium alloys, respectively. As a basis of comparison, the standard VK-15 (WC+15% Co) alloy was used. Some key physicomechanical characteristics of the materials investigated are presented. On time bases not exceeding 10/sup 6/ cycles, titanium carbide hard metals are comparable in fatigue resistance to the standard tungstencontaining hard metals.

  6. Cell reorientation under cyclic stretching.

    PubMed

    Livne, Ariel; Bouchbinder, Eran; Geiger, Benjamin

    2014-01-01

    Mechanical cues from the extracellular microenvironment play a central role in regulating the structure, function and fate of living cells. Nevertheless, the precise nature of the mechanisms and processes underlying this crucial cellular mechanosensitivity remains a fundamental open problem. Here we provide a novel framework for addressing cellular sensitivity and response to external forces by experimentally and theoretically studying one of its most striking manifestations--cell reorientation to a uniform angle in response to cyclic stretching of the underlying substrate. We first show that existing approaches are incompatible with our extensive measurements of cell reorientation. We then propose a fundamentally new theory that shows that dissipative relaxation of the cell's passively-stored, two-dimensional, elastic energy to its minimum actively drives the reorientation process. Our theory is in excellent quantitative agreement with the complete temporal reorientation dynamics of individual cells measured over a wide range of experimental conditions, thus elucidating a basic aspect of mechanosensitivity. PMID:24875391

  7. Cell reorientation under cyclic stretching

    NASA Astrophysics Data System (ADS)

    Livne, Ariel; Bouchbinder, Eran; Geiger, Benjamin

    2014-05-01

    Mechanical cues from the extracellular microenvironment play a central role in regulating the structure, function and fate of living cells. Nevertheless, the precise nature of the mechanisms and processes underlying this crucial cellular mechanosensitivity remains a fundamental open problem. Here we provide a novel framework for addressing cellular sensitivity and response to external forces by experimentally and theoretically studying one of its most striking manifestations—cell reorientation to a uniform angle in response to cyclic stretching of the underlying substrate. We first show that existing approaches are incompatible with our extensive measurements of cell reorientation. We then propose a fundamentally new theory that shows that dissipative relaxation of the cell’s passively-stored, two-dimensional, elastic energy to its minimum actively drives the reorientation process. Our theory is in excellent quantitative agreement with the complete temporal reorientation dynamics of individual cells measured over a wide range of experimental conditions, thus elucidating a basic aspect of mechanosensitivity.

  8. Cyclic Linearization and Island Repair in Sluicing

    ERIC Educational Resources Information Center

    Qiu, Chunan

    2009-01-01

    Cyclic Linearization is adopted to account for the island repair of Sluicing in English. The extraction of wh-phrase out of certain islands undergoes non-successive-cyclic movement, which yields conflicting ordering statements. The derivation can be rescued by deleting all ordering statements in IP, including those conflicting ones. Two arguments…

  9. Twisted Cyclic Cohomology and Modular Fredholm Modules

    NASA Astrophysics Data System (ADS)

    Rennie, Adam; Sitarz, Andrzej; Yamashita, Makoto

    2013-07-01

    Connes and Cuntz showed in [Comm. Math. Phys. 114 (1988), 515-526] that suitable cyclic cocycles can be represented as Chern characters of finitely summable semifinite Fredholm modules. We show an analogous result in twisted cyclic cohomology using Chern characters of modular Fredholm modules. We present examples of modular Fredholm modules arising from Podleś spheres and from SUq(2).

  10. Phase behaviors of cyclic diblock copolymers.

    PubMed

    Zhang, Guojie; Fan, Zhongyong; Yang, Yuliang; Qiu, Feng

    2011-11-01

    A spectral method of self-consistent field theory has been applied to AB cyclic block copolymers. Phase behaviors of cyclic diblock copolymers, such as order-disorder transition, order-order transition, and domain spacing size, have been studied, showing good consistency with previous experimental and theoretical results. Compared to linear diblocks, cyclic diblocks are harder to phase separate due to the topological constraint of the ring structure. A direct disorder-to-cylinder transition window is observed in the phase diagram, which is significantly different from the mean field phase diagram of linear diblock copolymers. The domain spacing size ratio between cyclic and linear diblock copolymers is typically close to 0.707, indicating in segregation that the cyclic polymer can be considered to be made up of linear diblocks with half of the original chain length. PMID:22070321

  11. The dependence of Escherichia coli asparaginase II formation on cyclic AMP and cyclic AMP receptor protein.

    PubMed

    Russell, L; Yamazaki, H

    1978-05-01

    The amount of asparaginase II in an Escherichia coli wild-type strain (cya+, crp+) markedly increased upon a shift from aerobic to anaerobic growth. However, no such increase occurred in a mutant (cya) lacking cyclic AMP synthesis unless supplemented with exogenous cyclic AMP. Since a mutant (crp) deficient in cyclic AMP receptor protein also did not support the anaerobic formation of this enzyme, it is concluded that the formation of E. coli asparaginase II depends on both cyclic AMP and cyclic AMP receptor protein. PMID:207402

  12. An order-by-disorder process in the cyclic phase of spin-2 condensate with a weak magnetic field

    SciTech Connect

    Zheng, Gong-Ping; Xu, Lei-Kuan; Qin, Shuai-Feng; Jian, Wen-Tian; Liang, J.-Q.

    2013-07-15

    We present in this paper a model study on the “order-by-disorder” process in the cyclic phase of spin-2 condensate, which forms a family of incommensurable, spiral degenerate ground states. On the basis of the ordering mechanism of entropic splitting, it is demonstrated that the energy corrections resulting from quantum fluctuations of disorder lift the accidental degeneracy of the cyclic configurations and thus lead to an eventual spiral order called the cyclic order. The order-by-disorder phenomenon is then realized even if the magnetic field exists. Finally, we show that our theoretic observations can be verified experimentally by direct detection of the cyclic order in the {sup 87}Rb condensate of a spin-2 manifold with a weak magnetic field. -- Highlights: •A model for the order-by-disorder process in the cyclic phase of spin-2 condensate is presented. •The second-order quantum fluctuations of the mean-field states are studied. •The energy corrections lift the accidental degeneracy of the cyclic configurations. •The order-by-disorder phenomenon is realized even if a magnetic field exists. •The theoretic observations can be verified experimentally for {sup 87}Rb condensate.

  13. Hidden observables in neutron quantum interferometry

    NASA Astrophysics Data System (ADS)

    Rauch, Helmut; Baron, Matthias; Filipp, Stefan; Hasegawa, Yuji; Lemmel, Hartmut; Loidl, Rudolf

    2006-11-01

    Neutron interferometry using monolithic perfect single crystals has become an important tool for fundamental, nuclear, and solid-state physics research. New features of quantum mechanics become measurable by means of neutron interferometry. Such features are quantum phases, which provide a more direct access to properties of wave functions and permit wave function reconstruction, and wave function engineering. Most recently, new experiments concerning off-diagonal and non-cyclic geometrical phases, confinement induced phases, and contextuality related experiments have been performed. These experiments show an intrinsic entanglement of different degrees of freedom of a single particle. Proper post-selection experiments yield to more quantum complete experiments and may help to make quantum mechanics less mystic. Unavoidable quantum losses may play an important role to explain the transition from the quantum to the classical world. All these investigations concern the heart of quantum mechanics and demonstrate the non-local feature of this theory.

  14. Mixed Strategies in cyclic competition

    NASA Astrophysics Data System (ADS)

    Intoy, Ben; Pleimling, Michel

    2015-03-01

    Physicists have been using evolutionary game theory to model and simulate cyclically competing species, with applications to lizard mating strategies and competing bacterial strains. However these models assume that each agent plays the same strategy, which is called a pure strategy in game theory, until they are beaten by a better strategy which they immediately adopt. We relax this constraint of an agent playing a single strategy by instead letting the agent pick its strategy randomly from a probability distribution, which is called a mixed strategy in game theory. This scheme is very similar to multiple occupancy models seen in the literature, the major difference being that interactions happen between sites rather than within them. Choosing strategies out of a distribution also has applications to economic/social systems such as the public goods game. We simulate a model of mixed strategy and cylic competition on a one-dimensional lattice with three and four strategies and find interesting spatial and stability properties depending on how discretized the choice of strategy is for the agents. This work is supported by the US National Science Foundation through Grant DMR-1205309.

  15. Asymmetric cyclic evolution in polymerised cosmology

    SciTech Connect

    Hrycyna, Orest; Mielczarek, Jakub; Szydłowski, Marek E-mail: jakub.mielczarek@uj.edu.pl

    2009-12-01

    The dynamical systems methods are used to study evolution of the polymerised scalar field cosmologies with the cosmological constant. We have found all evolutional paths admissible for all initial conditions on the two-dimensional phase space. We have shown that the cyclic solutions are generic. The exact solution for polymerised cosmology is also obtained. Two basic cases are investigated, the polymerised scalar field and the polymerised gravitational and scalar field part. In the former the division on the cyclic and non-cyclic behaviour is established following the sign of the cosmological constant. The value of the cosmological constant is upper bounded purely from the dynamical setting.

  16. Processable Cyclic Peptide Nanotubes with Tunable Interiors

    SciTech Connect

    Hourani, Rami; Zhang, Chen; van der Weegen, Rob; Ruiz, Luis; Li, Changyi; Keten, Sinan; Helms, Brett A.; Xu, Ting

    2011-09-06

    A facile route to generate cyclic peptide nanotubes with tunable interiors is presented. By incorporating 3-amino-2-methylbenzoic acid in the d,l-alternating primary sequence of a cyclic peptide, a functional group can be presented in the interior of the nanotubes without compromising the formation of high aspect ratio nanotubes. The new design of such a cyclic peptide also enables one to modulate the nanotube growth process to be compatible with the polymer processing window without compromising the formation of high aspect ratio nanotubes, thus opening a viable approach toward molecularly defined porous membranes.

  17. An order-by-disorder process in the cyclic phase of spin-2 condensate with a weak magnetic field

    NASA Astrophysics Data System (ADS)

    Zheng, Gong-Ping; Xu, Lei-Kuan; Qin, Shuai-Feng; Jian, Wen-Tian; Liang, J.-Q.

    2013-07-01

    We present in this paper a model study on the "order-by-disorder" process in the cyclic phase of spin-2 condensate, which forms a family of incommensurable, spiral degenerate ground states. On the basis of the ordering mechanism of entropic splitting, it is demonstrated that the energy corrections resulting from quantum fluctuations of disorder lift the accidental degeneracy of the cyclic configurations and thus lead to an eventual spiral order called the cyclic order. The order-by-disorder phenomenon is then realized even if the magnetic field exists. Finally, we show that our theoretic observations can be verified experimentally by direct detection of the cyclic order in the 87Rb condensate of a spin-2 manifold with a weak magnetic field.

  18. Geodesically complete analytic solutions for a cyclic universe

    SciTech Connect

    Bars, Itzhak; Chen, Shih-Hung; Turok, Neil

    2011-10-15

    We present analytic solutions to a class of cosmological models described by a canonical scalar field minimally coupled to gravity and experiencing self interactions through a hyperbolic potential. Using models and methods inspired by 2T-physics, we show how analytic solutions can be obtained in flat/open/closed Friedmann-Robertson-Walker universes. Among the analytic solutions, there are many interesting geodesically complete cyclic solutions in which the universe bounces at either zero or finite sizes. When geodesic completeness is imposed, it restricts models and their parameters to a certain parameter subspace, including some quantization conditions on initial conditions in the case of zero-size bounces, but no conditions on initial conditions for the case of finite-size bounces. We will explain the theoretical origin of our model from the point of view of 2T-gravity as well as from the point of view of the colliding branes scenario in the context of M-theory. We will indicate how to associate solutions of the quantum Wheeler-deWitt equation with our classical analytic solutions, mention some physical aspects of the cyclic solutions, and outline future directions.

  19. Synchronization in chaotic oscillators by cyclic coupling

    NASA Astrophysics Data System (ADS)

    Olusola, O. I.; Njah, A. N.; Dana, S. K.

    2013-07-01

    We introduce a type of cyclic coupling to investigate synchronization of chaotic oscillators. We derive analytical solutions of the critical coupling for stable synchronization under the cyclic coupling for the Rössler system and the Lorenz oscillator as paradigmatic illustration. Based on the master stability function (MSF) approach, the analytical results on critical coupling are verified numerically. An enhancing effect in terms of lowering the critical coupling or enlarging the synchronization window in a critical coupling space is noticed. The cyclic coupling is also applied in other models, Hindmarsh-Rose model, Sprott system, Chen system and forced Duffing system to confirm the enhancing effect. The cyclic coupling allows tuning of two coupling constants in reverse directions when an optimal control of synchronization is feasible.

  20. Antimicrobial Cyclic Peptides for Plant Disease Control

    PubMed Central

    Lee, Dong Wan; Kim, Beom Seok

    2015-01-01

    Antimicrobial cyclic peptides derived from microbes bind stably with target sites, have a tolerance to hydrolysis by proteases, and a favorable degradability under field conditions, which make them an attractive proposition for use as agricultural fungicides. Antimicrobial cyclic peptides are classified according to the types of bonds within the ring structure; homodetic, heterodetic, and complex cyclic peptides, which in turn reflect diverse physicochemical features. Most antimicrobial cyclic peptides affect the integrity of the cell envelope. This is achieved through direct interaction with the cell membrane or disturbance of the cell wall and membrane component biosynthesis such as chitin, glucan, and sphingolipid. These are specific and selective targets providing reliable activity and safety for non-target organisms. Synthetic cyclic peptides produced through combinatorial chemistry offer an alternative approach to develop antimicrobials for agricultural uses. Those synthesized so far have been studied for antibacterial activity, however, the recent advancements in powerful technologies now promise to provide novel antimicrobial cyclic peptides that are yet to be discovered from natural resources. PMID:25774105

  1. Quantum correlation via quantum coherence

    NASA Astrophysics Data System (ADS)

    Yu, Chang-shui; Zhang, Yang; Zhao, Haiqing

    2014-06-01

    Quantum correlation includes quantum entanglement and quantum discord. Both entanglement and discord have a common necessary condition—quantum coherence or quantum superposition. In this paper, we attempt to give an alternative understanding of how quantum correlation is related to quantum coherence. We divide the coherence of a quantum state into several classes and find the complete coincidence between geometric (symmetric and asymmetric) quantum discords and some particular classes of quantum coherence. We propose a revised measure for total coherence and find that this measure can lead to a symmetric version of geometric quantum correlation, which is analytic for two qubits. In particular, this measure can also arrive at a monogamy equality on the distribution of quantum coherence. Finally, we also quantify a remaining type of quantum coherence and find that for two qubits, it is directly connected with quantum nonlocality.

  2. Quantum memory Quantum memory

    NASA Astrophysics Data System (ADS)

    Le Gouët, Jean-Louis; Moiseev, Sergey

    2012-06-01

    Interaction of quantum radiation with multi-particle ensembles has sparked off intense research efforts during the past decade. Emblematic of this field is the quantum memory scheme, where a quantum state of light is mapped onto an ensemble of atoms and then recovered in its original shape. While opening new access to the basics of light-atom interaction, quantum memory also appears as a key element for information processing applications, such as linear optics quantum computation and long-distance quantum communication via quantum repeaters. Not surprisingly, it is far from trivial to practically recover a stored quantum state of light and, although impressive progress has already been accomplished, researchers are still struggling to reach this ambitious objective. This special issue provides an account of the state-of-the-art in a fast-moving research area that makes physicists, engineers and chemists work together at the forefront of their discipline, involving quantum fields and atoms in different media, magnetic resonance techniques and material science. Various strategies have been considered to store and retrieve quantum light. The explored designs belong to three main—while still overlapping—classes. In architectures derived from photon echo, information is mapped over the spectral components of inhomogeneously broadened absorption bands, such as those encountered in rare earth ion doped crystals and atomic gases in external gradient magnetic field. Protocols based on electromagnetic induced transparency also rely on resonant excitation and are ideally suited to the homogeneous absorption lines offered by laser cooled atomic clouds or ion Coulomb crystals. Finally off-resonance approaches are illustrated by Faraday and Raman processes. Coupling with an optical cavity may enhance the storage process, even for negligibly small atom number. Multiple scattering is also proposed as a way to enlarge the quantum interaction distance of light with matter. The

  3. Measuring Cyclic Error in Laser Heterodyne Interferometers

    NASA Technical Reports Server (NTRS)

    Ryan, Daniel; Abramovici, Alexander; Zhao, Feng; Dekens, Frank; An, Xin; Azizi, Alireza; Chapsky, Jacob; Halverson, Peter

    2010-01-01

    An improved method and apparatus have been devised for measuring cyclic errors in the readouts of laser heterodyne interferometers that are configured and operated as displacement gauges. The cyclic errors arise as a consequence of mixing of spurious optical and electrical signals in beam launchers that are subsystems of such interferometers. The conventional approach to measurement of cyclic error involves phase measurements and yields values precise to within about 10 pm over air optical paths at laser wavelengths in the visible and near infrared. The present approach, which involves amplitude measurements instead of phase measurements, yields values precise to about .0.1 microns . about 100 times the precision of the conventional approach. In a displacement gauge of the type of interest here, the laser heterodyne interferometer is used to measure any change in distance along an optical axis between two corner-cube retroreflectors. One of the corner-cube retroreflectors is mounted on a piezoelectric transducer (see figure), which is used to introduce a low-frequency periodic displacement that can be measured by the gauges. The transducer is excited at a frequency of 9 Hz by a triangular waveform to generate a 9-Hz triangular-wave displacement having an amplitude of 25 microns. The displacement gives rise to both amplitude and phase modulation of the heterodyne signals in the gauges. The modulation includes cyclic error components, and the magnitude of the cyclic-error component of the phase modulation is what one needs to measure in order to determine the magnitude of the cyclic displacement error. The precision attainable in the conventional (phase measurement) approach to measuring cyclic error is limited because the phase measurements are af-

  4. Cyclic fatigue mechanisms in partially stabilized zirconia

    SciTech Connect

    Hoffman, M.J.; Wakayama, Shuichi; Kawahara, Masanori; Mai, Y.W.; Kishi, Teruo

    1995-12-31

    Cyclic fatigue crack growth rate and crack resistance curve testing were undertaken on 6 different grades of Mg-PSZ. The width of the transformation zone at the flanks of the cracks was determined using Raman spectroscopy and, combined with R-curve toughening values, used to ascertain the level of crack-tip shielding during cyclic fatigue crack growth and hence the crack-tip stress intensity factor amplitude. By normalizing the crack-tip stress intensity factor amplitude with the intrinsic toughness of the material, it was found that the cyclic fatigue threshold stress intensity factor was independent of the extent of crack-tip shielding and a function of the stress intensity factor at the crack tip. In situ SEM observations of cyclic fatigue revealed crack bridging by uncracked ligaments and the precipitate phase. Under cyclic loading the precipitate bridges were postulated to undergo frictional degradation at the precipitate/matrix interface with the degree of degradation determined by the cyclic amplitude. Acoustic emission testing revealed acoustic emissions at three distinct levels during the loading cycle: firstly, near the maximum applied stress intensity factor caused by crack propagation; secondly, at the mid-range of the applied stress intensity factor attributed to crack closure near the crack tip, presumably as a result of transformation induced dilation; and thirdly, intermittently near the base of the loading cycle as a result of fracture surface contact due to surface roughness at a significant distance behind the crack tip. Crack closure near the crack tip due to dilation is proposed to significantly reduce the crack tip stress intensity factor amplitude and hence the degree of cyclic fatigue.

  5. Geometrical Phases in Quantum Mechanics

    NASA Astrophysics Data System (ADS)

    Christian, Joy Julius

    In quantum mechanics, the path-dependent geometrical phase associated with a physical system, over and above the familiar dynamical phase, was initially discovered in the context of adiabatically changing environments. Subsequently, Aharonov and Anandan liberated this phase from the original formulation of Berry, which used Hamiltonians, dependent on curves in a classical parameter space, to represent the cyclic variations of the environments. Their purely quantum mechanical treatment, independent of Hamiltonians, instead used the non-trivial topological structure of the projective space of one-dimensional subspaces of an appropriate Hilbert space. The geometrical phase, in their treatment, results from a parallel transport of the time-dependent pure quantum states along a curve in this space, which is endowed with an abelian connection. Unlike Berry, they were able to achieve this without resort to an adiabatic approximation or to a time-independent eigenvalue equation. Prima facie, these two approaches are conceptually quite different. After a review of both approaches, an exposition bridging this apparent conceptual gap is given; by rigorously analyzing a model composite system, it is shown that, in an appropriate correspondence limit, the Berry phase can be recovered as a special case from the Aharonov-Anandan phase. Moreover, the model composite system is used to show that Berry's correction to the traditional Born-Oppenheimer energy spectra indeed brings the spectra closer to the exact results. Then, an experimental arrangement to measure geometrical phases associated with cyclic and non-cyclic variations of quantum states of an entangled composite system is proposed, utilizing the fundamental ideas of the recently opened field of two-particle interferometry. This arrangement not only resolves the controversy regarding the true nature of the phases associated with photon states, but also unequivocally predicts experimentally accessible geometrical phases in a

  6. Novel pH-Sensitive Cyclic Peptides

    PubMed Central

    Weerakkody, Dhammika; Moshnikova, Anna; El-Sayed, Naglaa Salem; Adochite, Ramona-Cosmina; Slaybaugh, Gregory; Golijanin, Jovana; Tiwari, Rakesh K.; Andreev, Oleg A.; Parang, Keykavous; Reshetnyak, Yana K.

    2016-01-01

    A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical studies revealed the molecular mechanism of peptides action and localization within the lipid bilayer of the membrane at high and low pHs. The symmetric, c[(WE)4WC], and asymmetric, c[E4W5C], cyclic peptides translocated amanitin, a polar cargo molecule of similar size, across the lipid bilayer and induced cell death in a pH- and concentration-dependent manner. Fluorescently-labelled peptides were evaluated for targeting of acidic 4T1 mammary tumors in mice. The highest tumor to muscle ratio (5.6) was established for asymmetric cyclic peptide, c[E4W5C], at 24 hours after intravenous administration. pH-insensitive cyclic peptide c[R4W5C], where glutamic acid residues (E) were replaced by positively charged arginine residues (R), did not exhibit tumor targeting. We have introduced a novel class of cyclic peptides, which can be utilized as a new pH-sensitive tool in investigation or targeting of acidic tissue. PMID:27515582

  7. Cyclic depsipeptides as potential cancer therapeutics.

    PubMed

    Kitagaki, Jirouta; Shi, Genbin; Miyauchi, Shizuka; Murakami, Shinya; Yang, Yili

    2015-03-01

    Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and anti-inflammatory activities, have been identified from fungi, plants, and marine organisms. In particular, the potent effects of cyclic depsipeptides on tumor cells have led to a number of clinical trials evaluating their potential as chemotherapeutic agents. Although many of the trials have not achieved the desired results, romidepsin (FK228), a bicyclic depsipeptide that inhibits histone deacetylase, has been shown to have clinical efficacy in patients with refractory cutaneous T-cell lymphoma and has received Food and Drug Administration approval for use in treatment. In this review, we discuss antitumor cyclic depsipeptides that have undergone clinical trials and focus on their structural features, mechanisms, potential applications in chemotherapy, and pharmacokinetic and toxicity data. The results of this study indicate that cyclic depsipeptides could be a rich source of new cancer therapeutics. PMID:25419631

  8. Novel pH-Sensitive Cyclic Peptides.

    PubMed

    Weerakkody, Dhammika; Moshnikova, Anna; El-Sayed, Naglaa Salem; Adochite, Ramona-Cosmina; Slaybaugh, Gregory; Golijanin, Jovana; Tiwari, Rakesh K; Andreev, Oleg A; Parang, Keykavous; Reshetnyak, Yana K

    2016-01-01

    A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical studies revealed the molecular mechanism of peptides action and localization within the lipid bilayer of the membrane at high and low pHs. The symmetric, c[(WE)4WC], and asymmetric, c[E4W5C], cyclic peptides translocated amanitin, a polar cargo molecule of similar size, across the lipid bilayer and induced cell death in a pH- and concentration-dependent manner. Fluorescently-labelled peptides were evaluated for targeting of acidic 4T1 mammary tumors in mice. The highest tumor to muscle ratio (5.6) was established for asymmetric cyclic peptide, c[E4W5C], at 24 hours after intravenous administration. pH-insensitive cyclic peptide c[R4W5C], where glutamic acid residues (E) were replaced by positively charged arginine residues (R), did not exhibit tumor targeting. We have introduced a novel class of cyclic peptides, which can be utilized as a new pH-sensitive tool in investigation or targeting of acidic tissue. PMID:27515582

  9. Visualization of cyclic nucleotide dynamics in neurons

    PubMed Central

    Gorshkov, Kirill; Zhang, Jin

    2014-01-01

    The second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) transduce many neuromodulatory signals from hormones and neurotransmitters into specific functional outputs. Their production, degradation and signaling are spatiotemporally regulated to achieve high specificity in signal transduction. The development of genetically encodable fluorescent biosensors has provided researchers with useful tools to study these versatile second messengers and their downstream effectors with unparalleled spatial and temporal resolution in cultured cells and living animals. In this review, we introduce the general design of these fluorescent biosensors and describe several of them in more detail. Then we discuss a few examples of using cyclic nucleotide fluorescent biosensors to study regulation of neuronal function and finish with a discussion of advances in the field. Although there has been significant progress made in understanding how the specific signaling of cyclic nucleotide second messengers is achieved, the mechanistic details in complex cell types like neurons are only just beginning to surface. Current and future fluorescent protein reporters will be essential to elucidate the role of cyclic nucleotide signaling dynamics in the functions of individual neurons and their networks. PMID:25538560

  10. Further studies on cyclic erythropoiesis in mice

    SciTech Connect

    Gibson, C.M.; Gurney, C.W.; Simmons, E.L.; Gaston, E.O.

    1985-10-01

    When young adult female W/Wv mice are given 0.5 micro+Ci /sup 89/Sr/g body weight intravenously, their hematocrit values oscillate from nadirs of 26% to zeniths of 42% with a periodicity of 16 days. The response of the W/Wv mouse to an assortment of radioactive and hematologic stresses have been examined in an effort to understand better the pathophysiology of cyclic erythropoiesis. When the dose of /sup 89/Sr is increased, the amplitude of cycling increases as nadirs are lowered, but periodicity is unchanged. When the dose of /sup 89/Sr is lowered to 0.3 microCi or less, cyclic erythropoiesis of substantial amplitude is observed only after five or six microoscillations. A single hematopoietic insult of 80 rad x-irradiation coupled with phlebotomy produces a transient form of cyclic erythropoiesis, namely, a series of dampened oscillations prior to recovery. Finally, we report that Wv/Wv mice exhibit a form of cyclic erythropoiesis in response to 0.5 microCi /sup 89/Sr/g body weight, in which the hematocrit values of successive nadirs gradually increase, and stabilize at about 100 days. /sup 89/Sr does not induce cyclic erythropoiesis in the +/+, W/+, or W/v/+ mice, the Hertwig strain of anemic mice, or in normal BDF1 mice.

  11. Quantacell: powerful charging of quantum batteries

    NASA Astrophysics Data System (ADS)

    Binder, Felix C.; Vinjanampathy, Sai; Modi, Kavan; Goold, John

    2015-07-01

    We study the problem of charging a quantum battery in finite time. We demonstrate an analytical optimal protocol for the case of a single qubit. Extending this analysis to an array of N qubits, we demonstrate that an N-fold advantage in power per qubit can be achieved when global operations are permitted. The exemplary analytic argument for this quantum advantage in the charging power is backed up by numerical analysis using optimal control techniques. It is demonstrated that the quantum advantage for power holds when, with cyclic operation in mind, initial and final states are required to be separable.

  12. Cyclic and low temperature effects on microcircuits

    NASA Technical Reports Server (NTRS)

    Weissflug, V. A.; Sisul, E. V.

    1977-01-01

    Cyclic temperature and low temperature operating life tests, and pre-/post-life device evaluations were used to determine the degrading effects of thermal environments on microcircuit reliability. Low power transistor-transistor-logic gates and linear devices were included in each test group. Device metallization systems included aluminum metallization/aluminum wire, aluminum metallization/gold wire, and gold metallization/gold wire. Fewer than 2% electrical failures were observed during the cyclic and low temperature life tests and the post-life evaluations revealed approximately 2% bond pull failures. Reconstruction of aluminum die metallization was observed in all devices and the severity of the reconstruction appeared to be directly related to the magnitude of the temperature excursion. All types of bonds except the gold/gold bonds were weakened by exposure to repeated cyclic temperature stress.

  13. Quantum simulation

    NASA Astrophysics Data System (ADS)

    Georgescu, I. M.; Ashhab, S.; Nori, Franco

    2014-01-01

    Simulating quantum mechanics is known to be a difficult computational problem, especially when dealing with large systems. However, this difficulty may be overcome by using some controllable quantum system to study another less controllable or accessible quantum system, i.e., quantum simulation. Quantum simulation promises to have applications in the study of many problems in, e.g., condensed-matter physics, high-energy physics, atomic physics, quantum chemistry, and cosmology. Quantum simulation could be implemented using quantum computers, but also with simpler, analog devices that would require less control, and therefore, would be easier to construct. A number of quantum systems such as neutral atoms, ions, polar molecules, electrons in semiconductors, superconducting circuits, nuclear spins, and photons have been proposed as quantum simulators. This review outlines the main theoretical and experimental aspects of quantum simulation and emphasizes some of the challenges and promises of this fast-growing field.

  14. Asymmetric catalytic aziridination of cyclic enones.

    PubMed

    De Vincentiis, Francesco; Bencivenni, Giorgio; Pesciaioli, Fabio; Mazzanti, Andrea; Bartoli, Giuseppe; Galzerano, Patrizia; Melchiorre, Paolo

    2010-07-01

    The first catalytic method for the asymmetric aziridination of cyclic enones is described. The presented organocatalytic strategy is based on the use of an easily available organocatalyst that is able to convert a wide range of cyclic enones into the desired aziridines with very high enantiomeric purity and good chemical yield. Such a method may very well open up new opportunities to stereoselectively prepare complex chiral molecules that possess an indane moiety, a framework that is found in a large number of bioactive and pharmaceutically important molecules. PMID:20512797

  15. Perturbations in bouncing and cyclic models

    NASA Astrophysics Data System (ADS)

    Biswas, Tirthabir; Mayes, Riley; Lattyak, Colleen

    2016-03-01

    Being able to reliably track perturbations across bounces and turnarounds in cyclic and bouncing cosmology lies at the heart of being able to compare the predictions of these models with the cosmic microwave background observations. This has been a challenging task due to the unknown nature of the physics involved during the bounce as well as the technical challenge of matching perturbations precisely between the expansion and contraction phases. In this paper, we present some general techniques (analytical and numerical) that can be applied to understand the physics of the fluctuations, especially those with "long" wavelengths, and apply our techniques to nonsingular cosmological models such as the bounce inflation and cyclic inflation.

  16. Vasopressin treatment for cyclic antidepressant overdose.

    PubMed

    Barry, James David; Durkovich, David W; Williams, Saralyn R

    2006-07-01

    Due to neurotransmitter reuptake inhibition, peripheral alpha receptor blocking effects, and sodium channel blockade, severe cyclic antidepressant poisoning may lead to intractable hypotension. We report a case of severe amitriptyline toxicity, with hypotension unresponsive to direct alpha receptor agonists after pH manipulation, but improved with intravenous vasopressin. Vasopressin use in the setting of cyclic antidepressant toxicity has not been previously reported. Vasopressin may be a beneficial agent in the treatment of recalcitrant hypotension associated with poisoning or overdose. The anecdotal nature of this report must be emphasized and the use of vasopressin requires further research to define efficacy, dose, and potential side effects. PMID:16798158

  17. Generalized Coefficients for Hopf Cyclic Cohomology

    NASA Astrophysics Data System (ADS)

    Hassanzadeh, Mohammad; Kucerovsky, Dan; Rangipour, Bahram

    2014-09-01

    A category of coefficients for Hopf cyclic cohomology is defined. It is shown that this category has two proper subcategories of which the smallest one is the known category of stable anti Yetter-Drinfeld modules. The middle subcategory is comprised of those coefficients which satisfy a generalized SAYD condition depending on both the Hopf algebra and the (co)algebra in question. Some examples are introduced to show that these three categories are different. It is shown that all components of Hopf cyclic cohomology work well with the new coefficients we have defined.

  18. Cyclical rectal bleeding in colorectal endometriosis.

    PubMed

    Levitt, M D; Hodby, K J; van Merwyk, A J; Glancy, R J

    1989-12-01

    Three case reports of cyclical rectal bleeding in endometriosis affecting rectum and sigmoid colon emphasize the close relationship between such cyclical bleeding and intestinal endometriosis. The cause of bleeding, however, is still unclear. The predilection of endometriotic deposits for the outer layers of the bowel wall suggests that mucosal involvement is not a prerequisite for rectal bleeding. The frequent absence of identifiable intramural haemorrhage casts doubt on the premise that intestinal endometriotic deposits 'menstruate'. The cause may simply be a transient tear in normal mucosa due to swelling of an underlying endometriotic deposit at the time of menstruation. PMID:2597100

  19. Quantum networks reveal quantum nonlocality.

    PubMed

    Cavalcanti, Daniel; Almeida, Mafalda L; Scarani, Valerio; Acín, Antonio

    2011-01-01

    The results of local measurements on some composite quantum systems cannot be reproduced classically. This impossibility, known as quantum nonlocality, represents a milestone in the foundations of quantum theory. Quantum nonlocality is also a valuable resource for information-processing tasks, for example, quantum communication, quantum key distribution, quantum state estimation or randomness extraction. Still, deciding whether a quantum state is nonlocal remains a challenging problem. Here, we introduce a novel approach to this question: we study the nonlocal properties of quantum states when distributed and measured in networks. We show, using our framework, how any one-way entanglement distillable state leads to nonlocal correlations and prove that quantum nonlocality is a non-additive resource, which can be activated. There exist states, local at the single-copy level, that become nonlocal when taking several copies of them. Our results imply that the nonlocality of quantum states strongly depends on the measurement context. PMID:21304513

  20. Cyclic unequal error protection codes constructed from cyclic codes of composite length

    NASA Technical Reports Server (NTRS)

    Lin, Shu

    1987-01-01

    The distance structure of cyclic codes of composite length was investigated. A lower bound on the minimum distance for this class of codes is derived. In many cases, the lower bound gives the true minimum distance of a code. Then the distance structure of the direct sum of two cyclic codes of composite length were investigated. It was shown that, under certain conditions, the direct-sum code provides two levels of error correcting capability, and hence is a two-level unequal error protection (UEP) code. Finally, a class of two-level UEP cyclic direct-sum codes and a decoding algorithm for a subclass of these codes are presented.

  1. Quantum ontologies

    SciTech Connect

    Stapp, H.P.

    1988-12-01

    Quantum ontologies are conceptions of the constitution of the universe that are compatible with quantum theory. The ontological orientation is contrasted to the pragmatic orientation of science, and reasons are given for considering quantum ontologies both within science, and in broader contexts. The principal quantum ontologies are described and evaluated. Invited paper at conference: Bell's Theorem, Quantum Theory, and Conceptions of the Universe, George Mason University, October 20-21, 1988. 16 refs.

  2. An Experimental Test of Phonemic Cyclicity.

    ERIC Educational Resources Information Center

    Gierut, Judith A.

    1996-01-01

    Evaluates the principle of laryngeal-supralaryngeal cyclicity by manipulating the domain cycle and phase relationship of the cycle as independent variables and by monitoring longitudinally the order of emergent phonemic distinctions in the sound systems of seven children with phonological delays as the dependent variable. Findings are discussed.…

  3. One pot solution synthesis of cyclic oligodeoxyribonucleotides.

    PubMed Central

    Capobianco, M L; Carcuro, A; Tondelli, L; Garbesi, A; Bonora, G M

    1990-01-01

    Several cyclic oligodeoxynucleotides with different base composition and size have been prepared from 5',3'-unprotected linear precursors, using a bifunctional phosphorylating reagent. The final deprotected oligomers have been characterized by 1H- and 31P-NMR. The present procedure is particularly useful for millimolar scale syntheses. PMID:2339055

  4. One pot solution synthesis of cyclic oligodeoxyribonucleotides.

    PubMed

    Capobianco, M L; Carcuro, A; Tondelli, L; Garbesi, A; Bonora, G M

    1990-05-11

    Several cyclic oligodeoxynucleotides with different base composition and size have been prepared from 5',3'-unprotected linear precursors, using a bifunctional phosphorylating reagent. The final deprotected oligomers have been characterized by 1H- and 31P-NMR. The present procedure is particularly useful for millimolar scale syntheses. PMID:2339055

  5. Cyclic Cratonic Carbonates and Phanerozoic Calcite Seas.

    ERIC Educational Resources Information Center

    Wilkinson, Bruce H.

    1982-01-01

    Discusses causes of cyclicity in cratonic carbonate sequences and evidence for and potential significance of postulated primary calcite sediment components in past Paleozoic seas, outlining problems, focusing on models explaining existing data, and identifying background. Future sedimentary geologists will need to address these and related areas…

  6. Quantum Computer Games: Quantum Minesweeper

    ERIC Educational Resources Information Center

    Gordon, Michal; Gordon, Goren

    2010-01-01

    The computer game of quantum minesweeper is introduced as a quantum extension of the well-known classical minesweeper. Its main objective is to teach the unique concepts of quantum mechanics in a fun way. Quantum minesweeper demonstrates the effects of superposition, entanglement and their non-local characteristics. While in the classical…

  7. The geometric phase in quantum physics

    SciTech Connect

    Bohm, A.

    1993-03-01

    After an explanatory introduction, a quantum system in a classical time-dependent environment is discussed; an example is a magnetic moment in a classical magnetic field. At first, the general abelian case is discussed in the adiabatic approximation. Then the geometric phase for nonadiabatic change of the environment (Anandan--Aharonov phase) is introduced, and after that general cyclic (nonadiabatic) evolution is discussed. The mathematics of fiber bundles is introduced, and some of its results are used to describe the relation between the adiabatic Berry phase and the geometric phase for general cyclic evolution of a pure state. The discussion is restricted to the abelian, U(1) phase.

  8. Cyclic hardening in copper described in terms of combined monotonic and cyclic stress-strain curves

    SciTech Connect

    Chandler, H.D. . School of Mechanical Engineering)

    1995-01-01

    Hardening of polycrystalline copper subjected to tension-compression loading cycles in the plastic region is discussed with reference to changes in flow stress determined from equations describing dislocation glide. It is suggested that hardening is as a result of the accumulation of strain on a monotonic stress-strain curve. On initial loading, the behavior is monotonic. On stress reversal, a characteristic cyclic stress-strain curve is followed until the stress reaches a value in reverse loading corresponding to the maximum attained during the preceding half cycle. Thereafter, the monotonic path is followed until strain reversal occurs at completion of the half cycle. Repetition of the process results in cyclic hardening. Steady state cyclic behavior is reached when a stress associated with the monotonic stress-strain curve is reached which is equal to the stress associated with the cyclic stress-strain curve corresponding to the imposed strain amplitude.

  9. Theoretical predictions of chemical degradation reaction mechanisms of RDX and other cyclic nitramines derived from their molecular structures.

    PubMed

    Qasim, M; Fredrickson, H; McGrath, C; Furey, J; Bajpai, R

    2005-06-01

    Analysis of environmental degradation pathways of contaminants is aided by predictions of likely reaction mechanisms and intermediate products derived from computational models of molecular structure. Quantum mechanical methods and force-field molecular mechanics were used to characterize cyclic nitramines. Likely degradation mechanisms for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) include hydroxylation utilizing addition of hydroxide ions to initiate proton abstraction via 2nd order rate elimination (E2) or via nucleophilic substitution of nitro groups, reductive chemical and biochemical degradation, and free radical oxidation. Due to structural similarities, it is predicted that, under homologous circumstances, certain RDX environmental degradation pathways should also be effective for octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) and similar cyclic nitramines. Computational models provided a theoretical framework whereby likely transformation mechanisms and transformation products of cyclic nitramines were predicted and used to elucidate in situ degradation pathways. PMID:15804809

  10. Quantum memristors

    NASA Astrophysics Data System (ADS)

    Pfeiffer, P.; Egusquiza, I. L.; di Ventra, M.; Sanz, M.; Solano, E.

    2016-07-01

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantum regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. The proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems.

  11. Quantum memristors.

    PubMed

    Pfeiffer, P; Egusquiza, I L; Di Ventra, M; Sanz, M; Solano, E

    2016-01-01

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantum regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. The proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems. PMID:27381511

  12. Quantum memristors

    PubMed Central

    Pfeiffer, P.; Egusquiza, I. L.; Di Ventra, M.; Sanz, M.; Solano, E.

    2016-01-01

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantum regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. The proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems. PMID:27381511

  13. Quantum Primitives

    NASA Astrophysics Data System (ADS)

    Spring, Joseph

    2009-04-01

    We explore possible characterisations of entanglement classes which may be interpreted as gates acting on globally distributed systems. The cyclic nature of a selection of entanglement gates, primitives, is explored commencing with gates for generating Bell, GHZ and W states.

  14. Quantum model of light transmission in array waveguide gratings.

    PubMed

    Capmany, J; Mora, J; Fernández-Pousa, C R; Muñoz, P

    2013-06-17

    We develop, to the best of our knowledge, the first model for an array waveguide grating (AWG) device subject to quantum inputs and analyze its basic transformation functionalities for single-photon states. A commercial, cyclic AWG is experimentally characterized with weak input coherent states as a means of exploring its behaviour under realistic quantum detection. In particular it is shown the existence of a cutoff value of the average photon number below which quantum crosstalk between AWG ports is negligible with respect to dark counts. These results can be useful when considering the application of AWG devices to integrated quantum photonic systems. PMID:23787671

  15. 40 CFR 721.3440 - Haloalkyl substituted cyclic ethers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Haloalkyl substituted cyclic ethers... Substances § 721.3440 Haloalkyl substituted cyclic ethers. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances haloalkyl substituted cyclic ethers (PMN P-85-368 and...

  16. 40 CFR 721.3440 - Haloalkyl substituted cyclic ethers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Haloalkyl substituted cyclic ethers... Substances § 721.3440 Haloalkyl substituted cyclic ethers. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances haloalkyl substituted cyclic ethers (PMN P-85-368 and...

  17. Synthesis of cyclic sulfones by ring-closing metathesis.

    PubMed

    Yao, Qingwei

    2002-02-01

    A general and highly efficient synthesis of cyclic sulfones based on ring-closing metathesis has been developed. The synthetic utility of the resulting cyclic sulfones was demonstrated by their participation in stereoselective Diels-Alder reactions and transformation to cyclic dienes by the Ramberg-Bäcklund reaction. PMID:11820896

  18. Cyclic nucleotide signalling in kidney fibrosis

    PubMed Central

    Schinner, Elisabeth; Wetzl, Veronika; Schlossmann, Jens

    2015-01-01

    Kidney fibrosis is an important factor for the progression of kidney diseases, e.g., diabetes mellitus induced kidney failure, glomerulosclerosis and nephritis resulting in chronic kidney disease or end-stage renal disease. Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) were implicated to suppress several of the above mentioned renal diseases. In this review article, identified effects and mechanisms of cGMP and cAMP regarding renal fibrosis are summarized. These mechanisms include several signalling pathways of nitric oxide/ANP/guanylyl cyclases/cGMP-dependent protein kinase and cAMP/Epac/adenylyl cyclases/cAMP-dependent protein kinase. Furthermore, diverse possible drugs activating these pathways are discussed. From these diverse mechanisms it is expected that new pharmacological treatments will evolve for the therapy or even prevention of kidney failure. PMID:25622251

  19. Cyclic ethers adsorbed on Ru(001)

    NASA Astrophysics Data System (ADS)

    Walczak, M. M.; Thiel, P. A.

    1990-11-01

    The three cyclic ethers 1,3-dioxane. 1,4-dioxane and 1,3,5-trioxane all exhibit multiple desorption states from Ru(001) between 200 and 310 K, in addition to the multilayer and metastable states at lower temperature. Most distinctive are the two low-temperature α-states. which are similar in shape, position, and relative population for all three compounds. This suggests that these states are associated with configurations which are accessible to all three molecules. The data also indicate that there is some molecular decomposition to gaseous CO and H 2. 1,4-Dioxane yields the largest amounts of these decomposition products, suggesting that this molecule is most susceptible to surface-catalyzed decomposition. The desorption data for the three cyclic ethers are grossly similar to each other, and also to the straight-chain diethers which we have previously studied.

  20. Combustion oscillation control by cyclic fuel injection

    SciTech Connect

    Richards, G.A.; Yip, M.J.; Robey, E.; Cowell, L.; Rawlins, D.

    1997-04-01

    A number of recent articles have demonstrated the use of active control to mitigate the effects of combustion instability in afterburner and dump combustor applications. In these applications, cyclic injection of small quantities of control fuel has been proposed to counteract the periodic heat release that contributes to undesired pressure oscillations. This same technique may also be useful to mitigate oscillations in gas turbine combustors, especially in test rig combustors characterized by acoustic modes that do not exist in the final engine configuration. To address this issue, the present paper reports on active control of a subscale, atmospheric pressure nozzle.combustor arrangement. The fuel is natural gas. Cyclic injection of 14 percent control fuel in a premix fuel nozzle is shown to reduce oscillating pressure amplitude by a factor of 0.30 (i.e., {minus}10 dB) at 300 Hz. Measurement of the oscillating heat release is also reported.

  1. Cyclic debonding of adhesively bonded composites

    NASA Technical Reports Server (NTRS)

    Mall, S.; Johnson, W. S.; Everett, R. A., Jr.

    1982-01-01

    The fatigue behavior of a simple composite to composite bonded joint was analyzed. The cracked lap shear specimen subjected to constant amplitude cyclic loading was studied. Two specimen geometries were tested for each bonded system: (1) a strap adherend of 16 plies bonded to a lap adherend of 8 plies; and (2) a strap adherend of 8 plies bonded to a lap adherend of 16 plies. In all specimens the fatigue failure was in the form of cyclic debonding with some 0 deg fiber pull off from the strap adherend. The debond always grew in the region of adhesive that had the highest mode (peel) loading and that region was close to the adhesive strap interface.

  2. Separation of isotopes by cyclical processes

    DOEpatents

    Hamrin, Jr., Charles E.; Weaver, Kenny

    1976-11-02

    Various isotopes of hydrogen are separated by a cyclic sorption process in which a gas stream containing the isotopes is periodically passed through a high pressure column containing a palladium sorbent. A portion of the product from the high pressure column is passed through a second column at lower pressure to act as a purge. Before the sorbent in the high pressure column becomes saturated, the sequence is reversed with the stream flowing through the former low-pressure column now at high pressure, and a portion of the product purging the former high pressure column now at low pressure. The sequence is continued in cyclic manner with the product being enriched in a particular isotope.

  3. Combustion oscillation control by cyclic fuel injection

    SciTech Connect

    Richards, G.A.; Yip, M.J.; Robey, E.; Cowell, L.; Rawlins, D.

    1995-04-01

    A number of recent articles have demonstrated the use of active control to mitigate the effects of combustion instability in afterburner and dump combustor applications. In these applications, cyclic injection of small quantities of control fuel has been proposed to counteract the periodic heat release that contributes to undesired pressure oscillations. This same technique may also be useful to mitigate oscillations in gas turbine combustors, especially in test rig combustors characterized by acoustic modes that do not exist in the final engine configuration. To address this issue, the present paper reports on active control of a subscale, atmospheric pressure nozzle/combustor arrangement. The fuel is natural gas. Cyclic injection of 14% control fuel in a premix fuel nozzle is shown to reduce oscillating pressure amplitude by a factor of 0.30 (i.e., {approximately}10 dB) at 300 Hz. Measurement of the oscillating heat release is also reported.

  4. Universal Cyclic Topology in Polymer Networks.

    PubMed

    Wang, Rui; Alexander-Katz, Alfredo; Johnson, Jeremiah A; Olsen, Bradley D

    2016-05-01

    Polymer networks invariably possess topological defects: loops of different orders which have profound effects on network properties. Here, we demonstrate that all cyclic topologies are a universal function of a single dimensionless parameter characterizing the conditions for network formation. The theory is in excellent agreement with both experimental measurements of hydrogel loop fractions and Monte Carlo simulations without any fitting parameters. We demonstrate the superposition of the dilution effect and chain-length effect on loop formation. The one-to-one correspondence between the network topology and primary loop fraction demonstrates that the entire network topology is characterized by measurement of just primary loops, a single chain topological feature. Different cyclic defects cannot vary independently, in contrast to the intuition that the densities of all topological species are freely adjustable. Quantifying these defects facilitates studying the correlations between the topology and properties of polymer networks, providing a key step in overcoming an outstanding challenge in polymer physics. PMID:27203346

  5. Canine infectious cyclic thrombocytopenia found in Taiwan.

    PubMed

    Chang, A C; Chang, W L; Lin, C T; Pan, M J; Lee, S C

    1996-05-01

    Here were report the first canine infectious cyclic thrombocytopenia (CICT) found in Taiwan. Platelet-specific inclusions were detected in the blood smear of a military working dog. To identify the etiologic agent, the patient's blood was transmitted to three six-month-old German Shepherd dogs. The Ehrlichia platys-like inclusions were observed six to eight days after inoculation. Indirect fluorescent antibody test showed that the serum from the patient reacted specifically with the microorganisms within the platelets. Typical hematologic manifestations of E. platys infection, cyclic parasitemia and concomitant thrombocytopenia, were observed in these dogs. The prevalence of CICT in north Taiwan was also studied, and the incidence was 8.9% (4 out of 45) in civilian dogs and 97.1% (34 out of 35) in dogs from a heavily tick infested kennel. PMID:8741613

  6. Universal Cyclic Topology in Polymer Networks

    NASA Astrophysics Data System (ADS)

    Wang, Rui; Alexander-Katz, Alfredo; Johnson, Jeremiah A.; Olsen, Bradley D.

    2016-05-01

    Polymer networks invariably possess topological defects: loops of different orders which have profound effects on network properties. Here, we demonstrate that all cyclic topologies are a universal function of a single dimensionless parameter characterizing the conditions for network formation. The theory is in excellent agreement with both experimental measurements of hydrogel loop fractions and Monte Carlo simulations without any fitting parameters. We demonstrate the superposition of the dilution effect and chain-length effect on loop formation. The one-to-one correspondence between the network topology and primary loop fraction demonstrates that the entire network topology is characterized by measurement of just primary loops, a single chain topological feature. Different cyclic defects cannot vary independently, in contrast to the intuition that the densities of all topological species are freely adjustable. Quantifying these defects facilitates studying the correlations between the topology and properties of polymer networks, providing a key step in overcoming an outstanding challenge in polymer physics.

  7. Cyclic Oxidation Modeling and Life Prediction

    NASA Technical Reports Server (NTRS)

    Smialek, James L.

    2004-01-01

    The cyclic oxidation process can be described as an iterative scale growth and spallation sequence by a number of similar models. Model input variable include oxide scale type and growth parameters, spalling geometry, spall constant, and cycle duration. Outputs include net weight change, the amounts of retained and spalled oxide, the total oxygen and metal consumed, and the terminal rates of weight loss and metal consumption. All models and their variations produce a number of similar characteristic features. In general, spalling and material consumption increase to a steady state rate, at which point the retained scale approaches a constant and the rate of weight loss becomes linear. For one model, this regularity was demonstrated as dimensionless, universal expressions, obtained by normalizing the variables by critical performance factors. These insights were enabled through the use of the COSP for Windows cyclic oxidation spalling program.

  8. Quantum robots and quantum computers

    SciTech Connect

    Benioff, P.

    1998-07-01

    Validation of a presumably universal theory, such as quantum mechanics, requires a quantum mechanical description of systems that carry out theoretical calculations and systems that carry out experiments. The description of quantum computers is under active development. No description of systems to carry out experiments has been given. A small step in this direction is taken here by giving a description of quantum robots as mobile systems with on board quantum computers that interact with different environments. Some properties of these systems are discussed. A specific model based on the literature descriptions of quantum Turing machines is presented.

  9. Quantum hair and quantum gravity

    SciTech Connect

    Coleman, S. ); Krauss, L.M. ); Preskill, J. ); Wilczek, F. )

    1992-01-01

    A black hole may carry quantum numbers that are not associated with massless gauge fields, contrary to the spirit of the 'no-hair' theorems. The 'quantum hair' is invisible in the classical limit, but measurable via quantum interference experiments. Quantum hair alters the temperature of the radiation emitted by a black hole. It also induces non-zero expectation values for fields outside the event horizon; these expectation values are non-perturbative in [Dirac h], and decay exponentially far from the hole. The existence of quantum hair demonstrates that a black hole can have an intricate quantum-mechanical structure that is completely missed by standard semiclassical theory.

  10. Quantum Darwinism

    SciTech Connect

    Zurek, Wojciech H

    2008-01-01

    Quantum Darwinism - proliferation, in the environment, of multiple records of selected states of the system (its information-theoretic progeny) - explains how quantum fragility of individual state can lead to classical robustness of their multitude.

  11. Quantum Orbifolds

    NASA Astrophysics Data System (ADS)

    Harju, Antti J.

    2016-06-01

    This is a study of orbifold-quotients of quantum groups (quantum orbifolds {Θ } rightrightarrows Gq). These structures have been studied extensively in the case of the quantum S U 2 group. A generalized theory of quantum orbifolds over compact simple and simply connected quantum groups is developed. Associated with a quantum orbifold there is an invariant subalgebra and a crossed product algebra. For each spin quantum orbifold, there is a unitary equivalence class of Dirac spectral triples over the invariant subalgebra, and for each effective spin quantum orbifold associated with a finite group action, there is a unitary equivalence class of Dirac spectral triples over the crossed product algebra. A Hopf-equivariant Fredholm index problem is studied as an application.

  12. Quantum memristors

    DOE PAGESBeta

    Pfeiffer, P.; Egusquiza, I. L.; Di Ventra, M.; Sanz, M.; Solano, E.

    2016-07-06

    Technology based on memristors, resistors with memory whose resistance depends on the history of the crossing charges, has lately enhanced the classical paradigm of computation with neuromorphic architectures. However, in contrast to the known quantized models of passive circuit elements, such as inductors, capacitors or resistors, the design and realization of a quantum memristor is still missing. Here, we introduce the concept of a quantum memristor as a quantum dissipative device, whose decoherence mechanism is controlled by a continuous-measurement feedback scheme, which accounts for the memory. Indeed, we provide numerical simulations showing that memory effects actually persist in the quantummore » regime. Our quantization method, specifically designed for superconducting circuits, may be extended to other quantum platforms, allowing for memristor-type constructions in different quantum technologies. As a result, the proposed quantum memristor is then a building block for neuromorphic quantum computation and quantum simulations of non-Markovian systems.« less

  13. [Cyclic esotropia (alternate day squint) (author's transl)].

    PubMed

    Aichmair, H

    1977-02-10

    One case of the extremely rare conditioning of cyclic esotropia is reported following a short review of the literature and clinical features of this form of strabism. According to our experience the only effective treatment is operative correction on the day of the squint. It is not advisable to wait until the alternate day squint cycle breaks down and a permanent convergent squint develops. PMID:836616

  14. Asymmetric Redox-Annulation of Cyclic Amines

    PubMed Central

    2015-01-01

    Cyclic amines such as 1,2,3,4-tetrahydroisoquinoline undergo regiodivergent annulation reactions with 4-nitrobutyraldehydes. These redox-neutral transformations enable the asymmetric synthesis of highly substituted polycyclic ring systems in just two steps from commercial materials. The utility of this process is illustrated in a rapid synthesis of (−)-protoemetinol. Computational studies provide mechanistic insights and implicate the elimination of acetic acid from an ammonium nitronate intermediate as the rate-determining step. PMID:26348653

  15. Cyclic nucleotide phosphodiesterase 1 and vascular aging.

    PubMed

    Yan, Chen

    2015-12-01

    VSMCs (vascular smooth muscle cells) play critical roles in arterial remodelling with aging, hypertension and atherosclerosis. VSMCs exist in diverse phenotypes and exhibit phenotypic plasticity, e.g. changing from a quiescent/contractile phenotype to an active myofibroblast-like, often called 'synthetic', phenotype. Synthetic VSMCs are able to proliferate, migrate and secrete ECM (extracellular matrix) proteinases and ECM proteins. In addition, they produce pro-inflammatory molecules, providing an inflammatory microenvironment for leucocyte penetration, accumulation and activation. The aging VSMCs have also shown changes in cellular phenotype, responsiveness to contracting and relaxing mediators, replicating potential, matrix synthesis, inflammatory mediators and intracellular signalling. VSMC dysfunction plays a key role in age-associated vascular remodelling. Cyclic nucleotide PDEs (phosphodiesterases), by catalysing cyclic nucleotide hydrolysis, play a critical role in regulating the amplitude, duration and compartmentalization of cyclic nucleotide signalling. Abnormal alterations of PDEs and subsequent changes in cyclic nucleotide homoeostasis have been implicated in a number of different diseases. In the study published in the latest issue of Clinical Science, Bautista Niño and colleagues have shown that, in cultured senescent human VSMCs, PDE1A and PDE1C mRNA levels are significantly up-regulated and inhibition of PDE1 activity with vinpocetine reduced cellular senescent makers in senescent VSMCs. Moreover, in the premature aging mice with genomic instability (Ercc1(d/-)), impaired aortic ring relaxation in response to SNP (sodium nitroprusside), an NO (nitric oxide) donor, was also largely improved by vinpocetine. More interestingly, using data from human GWAS (genome-wide association studies), it has been found that PDE1A single nucleotide polymorphisms is significantly associated with diastolic blood pressure and carotid intima-media thickening, two

  16. Cyclic degassing of Erebus volcano, Antarctica

    NASA Astrophysics Data System (ADS)

    Ilanko, Tehnuka; Oppenheimer, Clive; Burgisser, Alain; Kyle, Philip

    2015-06-01

    Field observations have previously identified rapid cyclic changes in the behaviour of the lava lake of Erebus volcano. In order to understand more fully the nature and origins of these cycles, we present here a wavelet-based frequency analysis of time series measurements of gas emissions from the lava lake, obtained by open-path Fourier transform infrared spectroscopy. This reveals (i) a cyclic change in total gas column amount, a likely proxy for gas flux, with a period of about 10 min, and (ii) a similarly phased cyclic change in proportions of volcanic gases, which can be explained in terms of chemical equilibria and pressure-dependent solubilities. Notably, the wavelet analysis shows a persistent periodicity in the CO2/CO ratio and strong periodicity in H2O and SO2 degassing. The `peaks' of the cycles, defined by maxima in H2O and SO2 column amounts, coincide with high CO2/CO ratios and proportionally smaller increases in column amounts of CO2, CO, and OCS. We interpret the cycles to arise from recharge of the lake by intermittent pulses of magma from shallow depths, which degas H2O at low pressure, combined with a background gas flux that is decoupled from this very shallow magma degassing.

  17. Cyclic viscoelastoplasticity of polypropylene/nanoclay composites

    NASA Astrophysics Data System (ADS)

    Drozdov, A. D.; deC. Christiansen, J.

    2012-11-01

    Observations are reported on isotactic polypropylene/organically modified nanoclay hybrids with concentrations of filler ranging from 0 to 5 wt.% in cyclic tensile tests with a stress-controlled program (oscillations between various maximum stresses and the zero minimum stress). A pronounced effect of nanofiller is demonstrated: reinforcement with 2 wt.% of clay results in strong reduction of maximum and minimum strains per cycle and growth of number of cycles to failure compared with neat polypropylene. To rationalize these findings, a constitutive model is developed in cyclic viscoelasticity and viscoplasticity of polymer nanocomposites. Adjustable parameters in the stress-strain relations are found by fitting experimental data. The model correctly describes the growth of the ratcheting strain and shows that fatigue failure is driven by a pronounced increase in plastic strain in the crystalline phase. To assess the influence of loading conditions on the changes in the material parameters, experimental data on polypropylene are studied in cyclic tests with a strain-controlled program (oscillations between fixed maximum and minimum strains) and a mixed program (oscillations between various maximum strains and the zero minimum stress). Numerical simulation confirms the ability of the model to predict the evolution of stress-strain diagrams with the number of cycles.

  18. Cyclic energy harvesting from pyroelectric materials.

    PubMed

    Mane, Poorna; Xie, Jingsi; Leang, Kam K; Mossi, Karla

    2011-01-01

    A method of continuously harvesting energy from pyroelectric materials is demonstrated using an innovative cyclic heating scheme. In traditional pyroelectric energy harvesting methods, static heating sources are used, and most of the available energy has to be harvested at once. A cyclic heating system is developed such that the temperature varies between hot and cold regions. Although the energy harvested during each period of the heating cycle is small, the accumulated total energy over time may exceed traditional methods. Three materials are studied: a commonly available soft lead zirconate titanate (PZT), a pre-stressed PZT composite, and single-crystal PMN-30PT. Radiation heating and natural cooling are used such that, at smaller cyclic frequencies, the temporal rate of change in temperature is large enough to produce high power densities. The maximum power density of 8.64 μW/cm3 is generated with a PMN-30PT single crystal at an angular velocity of 0.64 rad/s with a rate of 8.5°C/s. The pre-stressed PZT composite generated a power density of 6.31 μW/cm(3), which is 40% larger than the density of 4.48 μW/cm3 obtained from standard PZT. PMID:21244970

  19. High-affinity Cyclic Peptide Matriptase Inhibitors*

    PubMed Central

    Quimbar, Pedro; Malik, Uru; Sommerhoff, Christian P.; Kaas, Quentin; Chan, Lai Y.; Huang, Yen-Hua; Grundhuber, Maresa; Dunse, Kerry; Craik, David J.; Anderson, Marilyn A.; Daly, Norelle L.

    2013-01-01

    The type II transmembrane serine protease matriptase is a key activator of multiple signaling pathways associated with cell proliferation and modification of the extracellular matrix. Deregulated matriptase activity correlates with a number of diseases, including cancer and hence highly selective matriptase inhibitors may have therapeutic potential. The plant-derived cyclic peptide, sunflower trypsin inhibitor-1 (SFTI-1), is a promising drug scaffold with potent matriptase inhibitory activity. In the current study we have analyzed the structure-activity relationships of SFTI-1 and Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II), a structurally divergent trypsin inhibitor from Momordica cochinchinensis that also contains a cyclic backbone. We show that MCoTI-II is a significantly more potent matriptase inhibitor than SFTI-1 and that all alanine mutants of both peptides, generated using positional scanning mutagenesis, have decreased trypsin affinity, whereas several mutations either maintain or result in enhanced matriptase inhibitory activity. These intriguing results were used to design one of the most potent matriptase inhibitors known to date with a 290 pm equilibrium dissociation constant, and provide the first indication on how to modulate affinity for matriptase over trypsin in cyclic peptides. This information might be useful for the design of more selective and therapeutically relevant inhibitors of matriptase. PMID:23548907

  20. Cyclic dominance in evolutionary games: a review

    PubMed Central

    Szolnoki, Attila; Mobilia, Mauro; Jiang, Luo-Luo; Szczesny, Bartosz; Rucklidge, Alastair M.; Perc, Matjaž

    2014-01-01

    Rock is wrapped by paper, paper is cut by scissors and scissors are crushed by rock. This simple game is popular among children and adults to decide on trivial disputes that have no obvious winner, but cyclic dominance is also at the heart of predator–prey interactions, the mating strategy of side-blotched lizards, the overgrowth of marine sessile organisms and competition in microbial populations. Cyclical interactions also emerge spontaneously in evolutionary games entailing volunteering, reward, punishment, and in fact are common when the competing strategies are three or more, regardless of the particularities of the game. Here, we review recent advances on the rock–paper–scissors (RPS) and related evolutionary games, focusing, in particular, on pattern formation, the impact of mobility and the spontaneous emergence of cyclic dominance. We also review mean-field and zero-dimensional RPS models and the application of the complex Ginzburg–Landau equation, and we highlight the importance and usefulness of statistical physics for the successful study of large-scale ecological systems. Directions for future research, related, for example, to dynamical effects of coevolutionary rules and invasion reversals owing to multi-point interactions, are also outlined. PMID:25232048

  1. Cyclic steaming in heavy oil diatomite

    SciTech Connect

    Kumar, M.; Beatty, F.D.

    1995-12-31

    Chevron currently uses cyclic steaming as a recovery method to produce economically its heavy oil diatomite resource in the Cymric field, San Joaquin Valley, California. A highly instrumented, cyclically steaming well from this field was simulated in this study to delineate important production mechanisms, to optimize operations, and to improve reservoir management. The model was constrained, as much as possible, by the available measured data. Results show that fluid flow from the well to the reservoir is primarily through the hydraulic fracture induced by the injected steam. Parameters with unique importance to modeling cyclic steaming in diatomites are: (1) induced fracture dimension (length and height), (2) matrix permeability, (3) oil/water capillary pressure, (4) grid size perpendicular to fracture face, and (5) producing bottomhole pressures. Additionally, parameters important for conventional steam injection processes, such as relative permeabilities and injected steam volume, quality, and rate, are important for diatomites also. Oil production rates and steam/oil ratios calculated by this model compare reasonably with field data.

  2. Cyclic dominance in evolutionary games: a review.

    PubMed

    Szolnoki, Attila; Mobilia, Mauro; Jiang, Luo-Luo; Szczesny, Bartosz; Rucklidge, Alastair M; Perc, Matjaž

    2014-11-01

    Rock is wrapped by paper, paper is cut by scissors and scissors are crushed by rock. This simple game is popular among children and adults to decide on trivial disputes that have no obvious winner, but cyclic dominance is also at the heart of predator-prey interactions, the mating strategy of side-blotched lizards, the overgrowth of marine sessile organisms and competition in microbial populations. Cyclical interactions also emerge spontaneously in evolutionary games entailing volunteering, reward, punishment, and in fact are common when the competing strategies are three or more, regardless of the particularities of the game. Here, we review recent advances on the rock-paper-scissors (RPS) and related evolutionary games, focusing, in particular, on pattern formation, the impact of mobility and the spontaneous emergence of cyclic dominance. We also review mean-field and zero-dimensional RPS models and the application of the complex Ginzburg-Landau equation, and we highlight the importance and usefulness of statistical physics for the successful study of large-scale ecological systems. Directions for future research, related, for example, to dynamical effects of coevolutionary rules and invasion reversals owing to multi-point interactions, are also outlined. PMID:25232048

  3. A criterion for lattice supersymmetry: cyclic Leibniz rule

    NASA Astrophysics Data System (ADS)

    Kato, Mitsuhiro; Sakamoto, Makoto; So, Hiroto

    2013-05-01

    It is old folklore that the violation of Leibniz rule on a lattice is an obstruction for constructing a lattice supersymmetric model. While it is still true for full supersymmetry, we show that a slightly modified form of the Leibniz rule, which we call cyclic Leibniz rule (CLR), is actually a criterion for the existence of partial lattice supersymmetry. In one dimension, we find sets of lattice difference operator and field multiplication smeared over lattice which satisfy the CLR under some natural assumptions such as translational invariance and locality. Thereby we construct a model of supersymmetric lattice quantum mechanics without spoiling locality. The CLR relation is coincident with the condition that the vanishing of the so-called surface term in the construction by lattice Nicolai map. We can construct superfield formalism with arbitrary superpotential. This also enables us to apply safely a localization technique to our model, because the kinetic term and the interaction terms of our model are independently invariant under the supersymmetry transformation. A preliminary attempt in finding a solution for the higher dimensional case is also discussed.

  4. Cyclic steady state stress-strain behavior of UHMW polyethylene.

    PubMed

    Krzypow, D J; Rimnac, C M

    2000-10-01

    To increase the long-term performance of total joint replacements, finite element analyses of ultra high molecular weight polyethylene (UHMWPE) components have been conducted to predict the effect of load on the stress and strain distributions occurring on and within these components. Early models incorporated the monotonic behavior of UHMWPE without considering the unloading and cyclic loading behavior. However, UHMWPE components undergo cyclic loading during use and at least two wear damage modes (pitting and delamination) are thought to be associated with the fatigue fracture properties of UHMWPE. The objective of this study was to examine the fully reversed uniaxial tension/compression cyclic steady state stress-strain behavior of UHMWPE as a first step towards developing a cyclic constitutive relationship for UHMWPE. The hypothesis that cycling results in a permanent change in the stress-strain relationship, that is, that the cyclic steady state represents a new cyclically stabilized state, was examined. It was found that, like other ductile polymers, UHMWPE substantially cyclically softens under fully reversed uniaxial straining. More cyclic softening occurred in tension than in compression. Furthermore, cyclic steady state was attained, but not cyclic stability. It is suggested that it may be more appropriate to base a material constitutive relationship for UHMWPE for finite element analyses of components upon a cyclically modified stress-strain relationship. PMID:10966018

  5. Reduced models of multi-stage cyclic structures using cyclic symmetry reduction and component mode synthesis

    NASA Astrophysics Data System (ADS)

    Tran, Duc-Minh

    2014-10-01

    Reduced models of multi-stage cyclic structures such as bladed-disk assemblies are developed by using the multi-stage cyclic symmetry reduction and/or component mode synthesis methods. The multi-stage cyclic symmetry reduction consists in writing the equations of the bladed disks, the inter-disk structures, the inter-disk constraints and the whole multi-stage coupled system in terms of the traveling wave coordinates for all the phase indexes of the reference sectors and for all the bladed disks. Several reduced coupled systems are then solved by selecting at each time only one or a few phase indexes for each bladed disk and by applying the cyclic symmetry boundary conditions. On the other hand, component mode synthesis methods are used either independently or in combination with the multi-stage cyclic symmetry reduction to obtain reduced models of the multi-stage structure. Two of them are particularly efficient, that are firstly component mode synthesis methods with interface modes applied on the bladed disks and secondly component mode synthesis methods with traveling wave coordinates applied on the reference sectors.

  6. The conformations of cyclic polymers in bidisperse blends of cyclic polymers

    NASA Astrophysics Data System (ADS)

    Lang, Michael

    2013-03-01

    The size of cyclic polymers in bidisperse blends of chemically identical molecules is analyzed by computer simulations. The compression of entangled rings can be explained by the changes in the penetrable fraction of the surface bounded by the ring. Corrections for small rings can be approximated by a concatenation probability 1 -POO that a cyclic polymer entraps at least one other cyclic polymer. Both results are in line with a previous work on the compression of entangled cyclic polymers in monodisperse melts. For entangled cyclic polymers, bond-bond correlations show a constant anti-correlation peak at a curvilinear distance of about ten segments that coincides with a horizontal tangent in the normalized mean square internal distances along the ring for sufficiently large degrees of polymerization. In consequence, the length scale of topological interactions must be considered as constant in contrast to a recent proposal by Sakaue. Our data is not in accord with an extension of the model of Cates and Deutsch to bidiperse blends of ring polymers.

  7. Quantum cheques

    NASA Astrophysics Data System (ADS)

    Moulick, Subhayan Roy; Panigrahi, Prasanta K.

    2016-06-01

    We propose the idea of a quantum cheque scheme, a cryptographic protocol in which any legitimate client of a trusted bank can issue a cheque, that cannot be counterfeited or altered in anyway, and can be verified by a bank or any of its branches. We formally define a quantum cheque and present the first unconditionally secure quantum cheque scheme and show it to be secure against any no-signalling adversary. The proposed quantum cheque scheme can been perceived as the quantum analog of Electronic Data Interchange, as an alternate for current e-Payment Gateways.

  8. Quantum cheques

    NASA Astrophysics Data System (ADS)

    Moulick, Subhayan Roy; Panigrahi, Prasanta K.

    2016-03-01

    We propose the idea of a quantum cheque scheme, a cryptographic protocol in which any legitimate client of a trusted bank can issue a cheque, that cannot be counterfeited or altered in anyway, and can be verified by a bank or any of its branches. We formally define a quantum cheque and present the first unconditionally secure quantum cheque scheme and show it to be secure against any no-signalling adversary. The proposed quantum cheque scheme can been perceived as the quantum analog of Electronic Data Interchange, as an alternate for current e-Payment Gateways.

  9. Quantum frames

    NASA Astrophysics Data System (ADS)

    Brown, Matthew J.

    2014-02-01

    The framework of quantum frames can help unravel some of the interpretive difficulties i the foundation of quantum mechanics. In this paper, I begin by tracing the origins of this concept in Bohr's discussion of quantum theory and his theory of complementarity. Engaging with various interpreters and followers of Bohr, I argue that the correct account of quantum frames must be extended beyond literal space-time reference frames to frames defined by relations between a quantum system and the exosystem or external physical frame, of which measurement contexts are a particularly important example. This approach provides superior solutions to key EPR-type measurement and locality paradoxes.

  10. Average diagonal entropy in nonequilibrium isolated quantum systems.

    PubMed

    Giraud, Olivier; García-Mata, Ignacio

    2016-07-01

    The diagonal entropy was introduced as a good entropy candidate especially for isolated quantum systems out of equilibrium. Here we present an analytical calculation of the average diagonal entropy for systems undergoing unitary evolution and an external perturbation in the form of a cyclic quench. We compare our analytical findings with numerical simulations of various quantum systems. Our calculations elucidate various heuristic relations proposed recently in the literature. PMID:27575092

  11. Efficient Synthesis of Cyclic Block Copolymers by Rotaxane Protocol by Linear/Cyclic Topology Transformation.

    PubMed

    Valentina, Stephanie; Ogawa, Takahiro; Nakazono, Kazuko; Aoki, Daisuke; Takata, Toshikazu

    2016-06-20

    High-yielding synthesis of cyclic block copolymer (CBC) using the rotaxane protocol by linear-cyclic polymer topology transformation was first demonstrated. Initial complexation of OH-terminated sec-ammonium salt and a crown ether was followed by the successive living ring-opening polymerizations of two lactones to a linear block copolymer having a rotaxane structure by the final capping of the propagation end. CBC was obtained in a high yield by an exploitation of the mechanical linkage through the translational movement of the rotaxane component to transform polymer structure from linear to cyclic. Furthermore, the change of the polymer topology was translated into a macroscopic change in crystallinity of the block copolymer. PMID:27037975

  12. Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS.

    PubMed Central

    Butt, E.; Pöhler, D.; Genieser, H. G.; Huggins, J. P.; Bucher, B.

    1995-01-01

    1. The modulation of the guanosine 3':5'-cyclic monophosphate (cyclic GMP)- and adenosine 3':5'-cyclic monophosphate (cyclic AMP)-dependent protein kinase activities by the diastereomers of 8-bromo-beta phenyl-1, N2-ethenoguanosine 3':5'-cyclic monophosphorothioate, ((Rp)- and (Sp)-8-bromo-PET-cyclic GMPS) was investigated by use of purified protein kinases. In addition, the effects of (Rp)-8-bromo-PET-cyclic GMPS on protein phosphorylation in intact human platelets and on [3H]-noradrenaline release and neurogenic vasoconstriction in electrical field stimulated rat tail arteries were also studied. 2. Kinetic analysis with purified cyclic GMP-dependent protein kinase (PKG) type I alpha and I beta, which are expressed in the rat tail artery, revealed that (Rp)-8-bromo-PET-cyclic GMPS is a competitive inhibitor with an apparent Ki of 0.03 microM. The activation of purified cyclic AMP-dependent protein kinase (PKA) type II was antagonized with an apparent Ki of 10 microM. 3. In human platelets, (Rp)-8-bromo-PET-cyclic GMPS (0.1 mM) antagonized the activation of the PKG by the selective activator 8-(4-chlorophenylthio)-guanosine 3':5'-cyclic monophosphate (8-pCPT-cyclic GMP; 0.2 mM) without affecting the activation of PKA by (Sp)-5, 6-dichloro-1-beta-D-ribofurano-sylbenzimidazole- 3':5'-cyclic monophosphorothioate ((Sp)-5,6-DCl-cyclic BiMPS; 0.1 mM). 4. (Rp)-8-bromo-PET-cyclic GMPS was not hydrolysed by the cyclic GMP specific phosphodiesterase (PDE) type V from bovine aorta but potently inhibited this PDE. 5. The corresponding sulphur free cyclic nucleotide of the two studied phosphorothioate derivatives, 8-bromo-beta-phenyl-1, N2-ethenoguanosine-3':5'-cyclic monophosphate (8-bromo-PET-cyclic GMP), had no effect on electrically-induced [3H]-noradrenaline release but concentration-dependently decreased the stimulation-induced vasoconstriction. (Rp)-8-bromo-PET-cyclic GMPS (3 microM) shifted the vasoconstriction response to the right without affecting stimulation evoked

  13. Cyclic AMP Receptor Protein-Aequorin Molecular Switch for Cyclic AMP

    PubMed Central

    Scott, Daniel; Hamorsky, Krystal Teasley; Ensor, C. Mark; Anderson, Kimberly W.; Daunert, Sylvia

    2011-01-01

    Molecular switches are designer molecules that combine the functionality of two individual proteins into one, capable of manifesting an “on/off” signal in response to a stimulus. These switches have unique properties and functionalities and thus, can be employed as nanosensors in a variety of applications. To that end, we have developed a bioluminescent molecular switch for cyclic AMP. Bioluminescence offers many advantages over fluorescence and other detection methods including the fact that there is essentially zero background signal in physiological fluids, allowing for more sensitive detection and monitoring. The switch was created by combining the properties of the cyclic AMP receptor protein (CRP), a transcriptional regulatory protein from E. coli that binds selectively to cAMP with those of aequorin, a bioluminescent photoprotein native of the jellyfish Aequorea victoria. Genetic manipulation to split the genetic coding sequence of aequorin in two and genetically attach the fragments to the N and C termini of CRP, resulted in a hybrid protein molecular switch. The conformational change experienced by CRP upon the binding of cyclic AMP is suspected to result in the observed loss of bioluminescent signal from aequorin. The “on/off” bioluminescence can be modulated by cyclic AMP over a range of several orders of magnitude in a linear fashion in addition to the capacity to detect changes in cellular cyclic AMP of intact cells exposed to different external stimuli without the need to lyse the cells. We envision that the molecular switch could find applications in vitro as well as in vivo cyclic AMP detection and/or imaging. PMID:21329338

  14. Universal quantum computation with unlabelled qubits

    NASA Astrophysics Data System (ADS)

    Severini, Simone

    2006-06-01

    We show that an nth root of the Walsh-Hadamard transform (obtained from the Hadamard gate and a cyclic permutation of the qubits), together with two diagonal matrices, namely a local qubit-flip (for a fixed but arbitrary qubit) and a non-local phase-flip (for a fixed but arbitrary coefficient), can do universal quantum computation on n qubits. A quantum computation, making use of n qubits and based on these operations, is then a word of variable length, but whose letters are always taken from an alphabet of cardinality three. Therefore, in contrast with other universal sets, no choice of qubit lines is needed for the application of the operations described here. A quantum algorithm based on this set can be interpreted as a discrete diffusion of a quantum particle on a de Bruijn graph, corrected on-the-fly by auxiliary modifications of the phases associated with the arcs.

  15. A classification of finite quantum kinematics

    NASA Astrophysics Data System (ADS)

    Tolar, J.

    2014-10-01

    Quantum mechanics in Hilbert spaces of finite dimension N is reviewed from the number theoretic point of view. For composite numbers N possible quantum kinematics are classified on the basis of Mackey's Imprimitivity Theorem for finite Abelian groups. This yields also a classification of finite Weyl-Heisenberg groups and the corresponding finite quantum kinematics. Simple number theory gets involved through the fundamental theorem describing all finite discrete Abelian groups of order N as direct products of cyclic groups, whose orders are powers of not necessarily distinct primes contained in the prime decomposition of N. The representation theoretic approach is further compared with the algebraic approach, where the basic object is the corresponding operator algebra. The consideration of fine gradings of this associative algebra then brings a fresh look on the relation between the mathematical formalism and physical realizations of finite quantum systems.

  16. Interactions of cyclic and non-cyclic naphthalene diimide derivatives with different nucleic acids.

    PubMed

    Czerwinska, Izabella; Sato, Shinobu; Juskowiak, Bernard; Takenaka, Shigeori

    2014-05-01

    Recently, strategy based on stabilization of G-quadruplex telomeric DNA by small organic molecule has been realized by naphthalene diimide derivatives (NDIs). At the same time NDIs bind to DNA duplex as threading intercalators. Here we present cyclic derivative of naphthalene diimide (ligand 1) as DNA-binding ligand with ability to recognition of different structures of telomeric G-quadruplexes and ability to bis-intercalate to double-stranded helixes. The results have been compared to non-cyclic derivative (ligand 2) and revealed that preferential binding of ligands to nucleic acids strongly depends on their topology and structural features of ligands. PMID:24726302

  17. Spectroscopic and Computational Study of Acetic Acid and Its Cyclic Dimer in the Near-Infrared Region.

    PubMed

    Beć, Krzysztof B; Futami, Yoshisuke; Wójcik, Marek J; Nakajima, Takahito; Ozaki, Yukihiro

    2016-08-11

    Anharmonic vibrational analysis of near-infrared (NIR) spectra of acetic acid was carried out by anharmonic quantum chemical calculation in a wide concentration range of its CCl4 solution. By predicting vibrational spectra of acetic acid for the first time over a wide NIR region, it was possible to elucidate the influence of the formation of acetic acid cyclic dimer on its NIR spectrum. Quantum chemical simulations were based on coupled cluster and density functional theory quantum methods. Additionally, Møller-Plesset perturbation theory was employed for the additional calculation of hydrogen bonding stabilization energies. An anharmonic vibrational analysis was performed with the use of generalized second-order vibrational perturbation theory (GVPT2). A hybrid approach was assumed, in which monomeric species was treated by CCSD(T)/aug-cc-pVDZ (harmonic approximation) and B3LYP/SNSD (anharmonic approximation) methods. For the cyclic dimer, B3LYP and B2PLYP single and double hybrid functionals, paired with an SNSD basis set, were employed. DFT calculations were augmented with additional empirical dispersion correction. It was found that quantum chemically calculated vibrational modes in the NIR region are in a good agreement with experimental data. The results of anharmonic vibrational analysis were supported by a harmonic shift analysis, for elucidating the very strong anharmonic coupling observed between stretching modes of hydrogen bonded bridge in the cyclic dimer. However, the calculated wavenumbers for combination modes of double hydrogen bonded bridge in the cyclic dimer, which are very sensitive to the formation of hydrogen bonding, were found to be underestimated by quantum chemical methods. Therefore, by band fitting, the wavenumbers and shape parameters for these bands were found, and the modeled spectra were adjusted accordingly. A high accuracy of simulated spectra was achieved, and a detailed analysis of the experimental NIR spectra of acetic acid

  18. Modelling water molecules inside cyclic peptide nanotubes

    NASA Astrophysics Data System (ADS)

    Tiangtrong, Prangsai; Thamwattana, Ngamta; Baowan, Duangkamon

    2016-03-01

    Cyclic peptide nanotubes occur during the self-assembly process of cyclic peptides. Due to the ease of synthesis and ability to control the properties of outer surface and inner diameter by manipulating the functional side chains and the number of amino acids, cyclic peptide nanotubes have attracted much interest from many research areas. A potential application of peptide nanotubes is their use as artificial transmembrane channels for transporting ions, biomolecules and waters into cells. Here, we use the Lennard-Jones potential and a continuum approach to study the interaction of a water molecule in a cyclo[(- D-Ala- L-Ala)_4-] peptide nanotube. Assuming that each unit of a nanotube comprises an inner and an outer tube and that a water molecule is made up of a sphere of two hydrogen atoms uniformly distributed over its surface and a single oxygen atom at the centre, we determine analytically the interaction energy of the water molecule and the peptide nanotube. Using this energy, we find that, independent of the number of peptide units, the water molecule will be accepted inside the nanotube. Once inside the nanotube, we show that a water molecule prefers to be off-axis, closer to the surface of the inner nanotube. Furthermore, our study of two water molecules inside the peptide nanotube supports the finding that water molecules form an array of a 1-2-1-2 file inside peptide nanotubes. The theoretical study presented here can facilitate thorough understanding of the behaviour of water molecules inside peptide nanotubes for applications, such as artificial transmembrane channels.

  19. Cyclical konzo epidemics and climate variability.

    PubMed

    Oluwole, Olusegun Steven A

    2015-03-01

    Konzo epidemics have occurred during droughts in the Democratic Republic of Congo (DR Congo) for >70 years, but also in Mozambique, Tanzania, and the Central African Republic. The illness is attributed to exposure to cyanide from cassava foods, on which the population depends almost exclusively during droughts. Production of cassava, a drought-resistant crop, has been shown to correlate with cyclical changes in precipitation in konzo-affected countries. Here we review the epidemiology of konzo as well as models of its pathogenesis. A spectral analysis of precipitation and konzo is performed to determine whether konzo epidemics are cyclical and whether there is spectral coherence. Time series of environmental temperature, precipitation, and konzo show cyclical changes. Periodicities of dominant frequencies in the spectra of precipitation and konzo range from 3 to 6 years in DR Congo. There is coherence of the spectra of precipitation and konzo. The magnitude squared coherence of 0.9 indicates a strong relationship between variability of climate and konzo epidemics. Thus, it appears that low precipitation phases of climate variability reduce the yield of food crops except cassava, upon which the population depends for supply of calories during droughts. Presence of very high concentrations of thiocyanate (SCN(-) ), the major metabolite of cyanide, in the bodily fluids of konzo subjects is a consequence of dietary exposure to cyanide, which follows intake of poorly processed cassava roots. Because cyanogens and minor metabolites of cyanide have not induced konzo-like illnesses, SCN(-) remains the most likely neurotoxicant of konzo. Public health control of konzo will require food and water programs during droughts. [Correction added on 26 February 2015, after first online publication: abstract reformatted per journal style] PMID:25523348

  20. Universal Behavior of a Cyclic Oxidation Model

    NASA Technical Reports Server (NTRS)

    Smialek, James L.

    2003-01-01

    A mathematical model has been generated to represent the iterative, discrete growth and spallation processes associated with cyclic oxidation. Parabolic growth kinetics (k(sub p)) over and a constant spall area (F(sub A)) were assumed, with spalling occurring interfacially at the thickest regions of the scale. Although most models require numerical techniques, the regularity and simplicity of this progression permitted an approximation by algebraic expressions. Normalization could now be performed to reflect all parametric effects, and a universal cyclic oxidation response was generated: W(sub u) = 1/2 {3J(sub u)(sup 1/2)+ J(sub u)(sup 3/2)} where W, is weight change normalized by the maximum and J(sub u) is the cycle number normalized by the number to reach maximum. Similarly, the total amount of metal consumed was represented by a single normalized curve. The factor [(S(sub c)-l)(raised dot)sqrt(F(sub A)k(sub p)DELTAt)] was identified as a general figure of merit, where S(sub c) is the mass ratio of oxide to oxygen and DELTAt is the cycle duration. A cyclic oxidation failure map was constructed, in normalized k(sub p)-F(sub A) space, as defined by the locus of points corresponding to a critical amount of metal consumption in a given time. All three constructions describe behavior for every value of growth rate, spall fraction, and cycle duration by means of single curves, but with two branches corresponding to the times before and after steady state is achieved.

  1. Recurrence of cyclic esotropia after surgical correction.

    PubMed

    Cahill, M; Walsh, J; McAleer, A

    1999-12-01

    Cyclic esotropia is a rare form of strabismus in which a convergent squint appears and disappears typically, but not always, in a regular 48-hour cycle. Characteristically, the convergent squint, when present, has a large angle with associated suppression and no binocular function. On normal or "nonsquinting" days, no manifest deviation is detectable (although in some cases there may be an esophoria). Physiologic diplopia is appreciated, whereas fusion and stereopsis are all normal. Amblyopia may occur in up to 20% of cases. PMID:10613585

  2. A cyclic universe approach to fine tuning

    NASA Astrophysics Data System (ADS)

    Alexander, Stephon; Cormack, Sam; Gleiser, Marcelo

    2016-06-01

    We present a closed bouncing universe model where the value of coupling constants is set by the dynamics of a ghost-like dilatonic scalar field. We show that adding a periodic potential for the scalar field leads to a cyclic Friedmann universe where the values of the couplings vary randomly from one cycle to the next. While the shuffling of values for the couplings happens during the bounce, within each cycle their time-dependence remains safely within present observational bounds for physically-motivated values of the model parameters. Our model presents an alternative to solutions of the fine tuning problem based on string landscape scenarios.

  3. Quantum Computing

    NASA Astrophysics Data System (ADS)

    Steffen, Matthias

    2013-03-01

    Quantum mechanics plays a crucial role in many day-to-day products, and has been successfully used to explain a wide variety of observations in Physics. While some quantum effects such as tunneling limit the degree to which modern CMOS devices can be scaled to ever reducing dimensions, others may potentially be exploited to build an entirely new computing architecture: The quantum computer. In this talk I will review several basic concepts of a quantum computer. Why quantum computing and how do we do it? What is the status of several (but not all) approaches towards building a quantum computer, including IBM's approach using superconducting qubits? And what will it take to build a functional machine? The promise is that a quantum computer could solve certain interesting computational problems such as factoring using exponentially fewer computational steps than classical systems. Although the most sophisticated modern quantum computing experiments to date do not outperform simple classical computations, it is increasingly becoming clear that small scale demonstrations with as many as 100 qubits are beginning to be within reach over the next several years. Such a demonstration would undoubtedly be a thrilling feat, and usher in a new era of controllably testing quantum mechanics or quantum computing aspects. At the minimum, future demonstrations will shed much light on what lies ahead.

  4. Quantum volume

    NASA Astrophysics Data System (ADS)

    Ryabov, V. A.

    2015-08-01

    Quantum systems in a mechanical embedding, the breathing mode of a small particles, optomechanical system, etc. are far not the full list of examples in which the volume exhibits quantum behavior. Traditional consideration suggests strain in small systems as a result of a collective movement of particles, rather than the dynamics of the volume as an independent variable. The aim of this work is to show that some problem here might be essentially simplified by introducing periodic boundary conditions. At this case, the volume is considered as the independent dynamical variable driven by the internal pressure. For this purpose, the concept of quantum volume based on Schrödinger’s equation in 𝕋3 manifold is proposed. It is used to explore several 1D model systems: An ensemble of free particles under external pressure, quantum manometer and a quantum breathing mode. In particular, the influence of the pressure of free particle on quantum oscillator is determined. It is shown also that correction to the spectrum of the breathing mode due to internal degrees of freedom is determined by the off-diagonal matrix elements of the quantum stress. The new treatment not using the “force” theorem is proposed for the quantum stress tensor. In the general case of flexible quantum 3D dynamics, quantum deformations of different type might be introduced similarly to monopole mode.

  5. Quantum games as quantum types

    NASA Astrophysics Data System (ADS)

    Delbecque, Yannick

    In this thesis, we present a new model for higher-order quantum programming languages. The proposed model is an adaptation of the probabilistic game semantics developed by Danos and Harmer [DH02]: we expand it with quantum strategies which enable one to represent quantum states and quantum operations. Some of the basic properties of these strategies are established and then used to construct denotational semantics for three quantum programming languages. The first of these languages is a formalisation of the measurement calculus proposed by Danos et al. [DKP07]. The other two are new: they are higher-order quantum programming languages. Previous attempts to define a denotational semantics for higher-order quantum programming languages have failed. We identify some of the key reasons for this and base the design of our higher-order languages on these observations. The game semantics proposed in this thesis is the first denotational semantics for a lambda-calculus equipped with quantum types and with extra operations which allow one to program quantum algorithms. The results presented validate the two different approaches used in the design of these two new higher-order languages: a first one where quantum states are used through references and a second one where they are introduced as constants in the language. The quantum strategies presented in this thesis allow one to understand the constraints that must be imposed on quantum type systems with higher-order types. The most significant constraint is the fact that abstraction over part of the tensor product of many unknown quantum states must not be allowed. Quantum strategies are a new mathematical model which describes the interaction between classical and quantum data using system-environment dialogues. The interactions between the different parts of a quantum system are described using the rich structure generated by composition of strategies. This approach has enough generality to be put in relation with other

  6. Quantum flywheel

    NASA Astrophysics Data System (ADS)

    Levy, Amikam; Diósi, Lajos; Kosloff, Ronnie

    2016-05-01

    In this work we present the concept of a quantum flywheel coupled to a quantum heat engine. The flywheel stores useful work in its energy levels, while additional power is extracted continuously from the device. Generally, the energy exchange between a quantum engine and a quantized work repository is accompanied by heat, which degrades the charging efficiency. Specifically when the quantum harmonic oscillator acts as a work repository, quantum and thermal fluctuations dominate the dynamics. Quantum monitoring and feedback control are applied to the flywheel in order to reach steady state and regulate its operation. To maximize the charging efficiency one needs a balance between the information gained by measuring the system and the information fed back to the system. The dynamics of the flywheel are described by a stochastic master equation that accounts for the engine, the external driving, the measurement, and the feedback operations.

  7. Quantum Groupoids

    NASA Astrophysics Data System (ADS)

    Xu, Ping

    We introduce a general notion of quantum universal enveloping algebroids (QUE algebroids), or quantum groupoids, as a unification of quantum groups and star-products. Some basic properties are studied including the twist construction and the classical limits. In particular, we show that a quantum groupoid naturally gives rise to a Lie bialgebroid as a classical limit. Conversely, we formulate a conjecture on the existence of a quantization for any Lie bialgebroid, and prove this conjecture for the special case of regular triangular Lie bialgebroids. As an application of this theory, we study the dynamical quantum groupoid , which gives an interpretation of the quantum dynamical Yang-Baxter equation in terms of Hopf algebroids.

  8. Quantifying Quantumness

    NASA Astrophysics Data System (ADS)

    Braun, Daniel; Giraud, Olivier; Braun, Peter A.

    2010-03-01

    We introduce and study a measure of ``quantumness'' of a quantum state based on its Hilbert-Schmidt distance from the set of classical states. ``Classical states'' were defined earlier as states for which a positive P-function exists, i.e. they are mixtures of coherent states [1]. We study invariance properties of the measure, upper bounds, and its relation to entanglement measures. We evaluate the quantumness of a number of physically interesting states and show that for any physical system in thermal equilibrium there is a finite critical temperature above which quantumness vanishes. We then use the measure for identifying the ``most quantum'' states. Such states are expected to be potentially most useful for quantum information theoretical applications. We find these states explicitly for low-dimensional spin-systems, and show that they possess beautiful, highly symmetric Majorana representations. [4pt] [1] Classicality of spin states, Olivier Giraud, Petr Braun, and Daniel Braun, Phys. Rev. A 78, 042112 (2008)

  9. Investigation of Cyclic Deformation and Fatigue of Polycrystalline Cu under Pure Compression Cyclic Loading Conditions

    NASA Astrophysics Data System (ADS)

    Hsu, Tzu-Yin Jean

    It is commonly accepted that fatigue crack is initiated under tensile fatigue stresses. However, practical examples demonstrate that cracks may also initiate under pure compressive fluctuating loads such as the failures observed in aircraft landing gear frames. However, the mechanism of such failures is rarely investigated. Furthermore, knowledge on cyclic deformation response under pure compressive fatigue condition is also very limited or non-existent. Our recent work already verified that fatigue cracks may nucleate from stress concentration sites under pure compression fatigue, but whether or not a form of stress concentration is always needed to initiate a crack under pure compression fatigue remains uncertain. In this study, compression fatigue tests under different peak stresses were carried out on smooth bars of fully annealed OFHC Copper. The purpose of these tests is to investigate not only the cyclic deformation response but also the possibility of crack nucleation without the stress concentrator. Results showed that overall the cyclic stress-strain response and microstructural evolution of OFHC Copper under pure compression fatigue exhibits rather dissimilar behaviour compared to those under symmetrical fatigue. The specimens hardened rapidly within 10 cycles under pure compression fatigue unlike the gradual cyclic hardening behaviour in symmetrical fatigue with the same peak stress amplitude. Compressive cyclic creep behaviour was also observed under the same testing conditions. Moreover, unlike conventional tension-compression fatigue, only moderate slip activity was detectable on the surface instead of typical PSB features detected from TEM observations. The surface observations has revealed that surface slip bands did not increase in number nor did they become more pronounced in height with increasing number of cycles. In addition, surface roughening by grain boundary extrusion was detected to become more severe as the cycling progressed. Therefore

  10. Rf cavity primer for cyclic proton accelerators

    NASA Astrophysics Data System (ADS)

    Griffin, J. E.

    1988-04-01

    The electrical and mechanical properities of particle accelerator rf cavities are described in a manner which will be useful to physics and engineering graduates entering the accelerator field. The discussion is limited to proton (or antiproton) synchrotron accelerators or storage rings operating roughly in the range of 20 to 200 MHz. The very high gradient, fixed frequency UHF or microwave devices appropriate for electron machines and the somewhat lower frequency and broader bandwidth devices required for heavy ion accelerators are discussed extensively in other papers in this series. While it is common practice to employ field calculation programs such as SUPERFISH, URMEL, or MAFIA as design aids in the development of rf cavities, we attempt here to elucidate various of the design parameters commonly dealt with in proton machines through the use of simple standing wave coaxial resonator expressions. In so doing, we treat only standing wave structures. Although low-impedance, moderately broad pass-band travelling wave accelerating systems are used in the CERN SPS, such systems are more commonly found in linacs, and they have not been used widely in large cyclic accelerators. Two appendices providing useful supporting material regarding relativistic particle dynamics and synchrotron motion in cyclic accelerators are added to supplement the text.

  11. Cyclical components of local rainfall data

    NASA Astrophysics Data System (ADS)

    Mentz, R. P.; D'Urso, M. A.; Jarma, N. M.; Mentz, G. B.

    2000-02-01

    This paper reports on the use of a comparatively simple statistical methodology to study local short time series rainfall data. The objective is to help in agricultural planning, by diminishing the risks associated with some uncertainties affecting this business activity.The analysis starts by assuming a model of unobservable components, trend, cycle, seasonal and irregular, that is well known in many areas of application. When series are in the realm of business and economics, the statistical methods popularized by the US Census Bureau US National Bureau of Economic Research are used for seasonal and cyclical estimation, respectively. The flexibility of these methods makes them good candidates to be applied in the meteorological context, and this is done in this paper for a selection of monthly rainfall time series.Use of the results to help in analysing and forecasting cyclical components is emphasized. The results are interesting. An agricultural entrepreneur, or a group of them located in a single geographical region, will profit by systematically collecting information (monthly in our work) about rainfall, and adopting the scheme of analysis described in this paper.

  12. Superplastic deformation induced by cyclic hydrogen charging

    SciTech Connect

    Choe, Heeman; Schuh, Christopher A.; Dunand, David C.

    2008-05-15

    Deformation under the combined action of external stress and cyclic hydrogen charging/discharging is studied in a model material, titanium. Cyclic charging with hydrogen is carried out at 860 deg. C, which repeatedly triggers the transformation between hydrogen-lean {alpha}-Ti and hydrogen-rich {beta}-Ti. Due to bias from the externally applied tensile stress, the internal mismatch strains produced by this isothermal {alpha}-{beta} transformation accumulate preferentially along the loading axis. These strain increments are linearly proportional to the applied stress, i.e., flow is ideally Newtonian, at small stress levels (below {approx}2 MPa). Therefore, after multiple chemical cycles, a tensile engineering strain of 100% is achieved without fracture, with an average strain rate of 10{sup -5} s{sup -1}, which demonstrates for the first time that superplastic elongations can be achieved by chemical cycling. The effect of hydrogen partial pressure, cycle time, and external stress on the value of the superplastic strain increments is experimentally measured and discussed in light of a diffusional phase transformation model. Special attention is paid to understanding the two contributions to the internal mismatch strains from the phase transformation and lattice swelling.

  13. Strain gradient effects on cyclic plasticity

    NASA Astrophysics Data System (ADS)

    Niordson, Christian F.; Legarth, Brian Nyvang

    2010-04-01

    Size effects on the cyclic shear response are studied numerically using a recent higher order strain gradient visco-plasticity theory accounting for both dissipative and energetic gradient hardening. Numerical investigations of the response under cyclic pure shear and shear of a finite slab between rigid platens have been carried out, using the finite element method. It is shown for elastic-perfectly plastic solids how dissipative gradient effects lead to increased yield strength, whereas energetic gradient contributions lead to increased hardening as well as a Bauschinger effect. For linearly hardening materials it is quantified how dissipative and energetic gradient effects promote hardening above that of conventional predictions. Usually, increased hardening is attributed to energetic gradient effects, but here it is found that also dissipative gradient effects lead to additional hardening in the presence of conventional material hardening. Furthermore, it is shown that dissipative gradient effects can lead to both an increase and a decrease in the dissipation per load cycle depending on the magnitude of the dissipative length parameter, whereas energetic gradient effects lead to decreasing dissipation for increasing energetic length parameter. For dissipative gradient effects it is found that dissipation has a maximum value for some none zero value of the material length parameter, which depends on the magnitude of the deformation cycles.

  14. Effect of Registration on Cyclical Kinematic Data

    PubMed Central

    Crane, Elizabeth A.; Cassidy, Ruth B.; Rothman, Edward D.; Gerstner, Geoffrey E.

    2010-01-01

    Given growing interest in Functional Data Analysis (FDA) as a useful method for analyzing human movement data, it is critical to understand the effects of standard FDA procedures, including registration, on biomechanical analyses. Registration is used to reduce phase variability between curves while preserving the individual curves shape and amplitude. The application of three methods available to assess registration could benefit those in the biomechanics community using FDA techniques: comparison of mean curves, comparison of average RMS values, and assessment of time-warping functions. Therefore, the present study has two purposes. First, the necessity of registration applied to cyclical data after time normalization is assessed. Second, we illustrate the three methods for evaluating registration effects. Masticatory jaw movements of 22 healthy adults (2 males, 21 females) were tracked while subjects chewed a gum-based pellet for 20 seconds. Motion data were captured at 60 Hz with two gen-locked video cameras. Individual chewing cycles were time normalized and then transformed into functional observations. Registration did not affect mean curves and warping functions were linear. Although registration decreased the RMS, indicating a decrease in inter-subject variability, the difference was not statistically significant. Together these results indicate that registration may not always be necessary for cyclical chewing data. An important contribution of this paper is the illustration of three methods for evaluating registration that are easy to apply and useful for judging whether the extra data manipulation is necessary. PMID:20537335

  15. Energy Storage of Linear and Cyclic Electron Flows in Photosynthesis 1

    PubMed Central

    Cha, Yuan; Mauzerall, David C.

    1992-01-01

    The energy storage of photosynthesis in the green alga Chlorella vulgaris was determined by pulsed, time-resolved photoacoustics. The energy storage of the linear electron transfer process in photosynthesis, of cyclic photosystem (PS) I, and possibly of PSII was determined by selection of excitation wavelength and of flash interval. At 695 nm excitation, a rather large cyclic PSI energy storage of 0.68 ± 0.04 eV/quantum of energy at 8 ms after a 1-μs flash was obtained. This energy remained the same at flash intervals of 0.35 to 60 s and was independent of the presence of 3-(3,4-dichlorophenyl)-1,1-dimethylurea. We tentatively assign this energy to the ferredoxin-NADP-reductase-ferredoxin and oxidized cytochrome b6/f complexes. An efficient distribution of energy between cyclic and linear systems is obtained with the simple assumption that the turnover time of the cyclic system is slower than that of the linear system. The energy storage of linear electron flow was determined by 655 nm excitation of Chlorella with a short flash interval of 0.35 s per flash. It was calculated to be 0.50 ± 0.03 eV/hv, close to that expected for oxygen and NADPH formation. The energy storage of PSII is determined by excitation of Chlorella at 655 nm with a long flash interval of 60 s per flash. It was calculated to be 1.07 ± 0.05 eV/hv, consistent with the energy storage being in S-states and the secondary electron acceptor of PSII with a calculated redox energy of 1.03 eV/hv. In the presence of 1 μm 3-(3,4-dichlorophenyl)-1,1-dimethylurea, the calculated energy storage in PSII is still significant, 0.53 ± 0.04 eV/hv. This probably indicates a significant cyclic electron flow around PSII. These cyclic flows may contribute considerably to energy storage in photosynthesis. PMID:16653211

  16. Abstract Algebra, Projective Geometry and Time Encoding of Quantum Information

    NASA Astrophysics Data System (ADS)

    Planat, Michel; Saniga, Metod

    2005-10-01

    Algebraic geometrical concepts are playing an increasing role in quantum applications such as coding, cryptography, tomography and computing. We point out here the prominent role played by Galois fields viewed as cyclotomic extensions of the integers modulo a prime characteristic p. They can be used to generate efficient cyclic encoding, for transmitting secrete quantum keys, for quantum state recovery and for error correction in quantum computing. Finite projective planes and their generalization are the geometric counterpart to cyclotomic concepts, their coordinatization involves Galois fields, and they have been used repetitively for enciphering and coding. Finally, the characters over Galois fields are fundamental for generating complete sets of mutually unbiased bases, a generic concept of quantum information processing and quantum entanglement. Gauss sums over Galois fields ensure minimum uncertainty under such protocols. Some Galois rings which are cyclotomic extensions of the integers modulo 4 are also becoming fashionable for their role in time encoding and mutual unbiasedness.

  17. Quantum criticality.

    PubMed

    Coleman, Piers; Schofield, Andrew J

    2005-01-20

    As we mark the centenary of Albert Einstein's seminal contribution to both quantum mechanics and special relativity, we approach another anniversary--that of Einstein's foundation of the quantum theory of solids. But 100 years on, the same experimental measurement that puzzled Einstein and his contemporaries is forcing us to question our understanding of how quantum matter transforms at ultra-low temperatures. PMID:15662409

  18. Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides.

    PubMed

    Liu, Wei-Ting; Ng, Julio; Meluzzi, Dario; Bandeira, Nuno; Gutierrez, Marcelino; Simmons, Thomas L; Schultz, Andrew W; Linington, Roger G; Moore, Bradley S; Gerwick, William H; Pevzner, Pavel A; Dorrestein, Pieter C

    2009-06-01

    Natural and non-natural cyclic peptides are a crucial component in drug discovery programs because of their considerable pharmaceutical properties. Cyclosporin, microcystins, and nodularins are all notable pharmacologically important cyclic peptides. Because these biologically active peptides are often biosynthesized nonribosomally, they often contain nonstandard amino acids, thus increasing the complexity of the resulting tandem mass spectrometry data. In addition, because of the cyclic nature, the fragmentation patterns of many of these peptides showed much higher complexity when compared to related counterparts. Therefore, at the present time it is still difficult to annotate cyclic peptides MS/MS spectra. In this current work, an annotation program was developed for the annotation and characterization of tandem mass spectra obtained from cyclic peptides. This program, which we call MS-CPA is available as a web tool (http://lol.ucsd.edu/ms-cpa_v1/Input.py). Using this program, we have successfully annotated the sequence of representative cyclic peptides, such as seglitide, tyrothricin, desmethoxymajusculamide C, dudawalamide A, and cyclomarins, in a rapid manner and also were able to provide the first-pass structure evidence of a newly discovered natural product based on predicted sequence. This compound is not available in sufficient quantities for structural elucidation by other means such as NMR. In addition to the development of this cyclic annotation program, it was observed that some cyclic peptides fragmented in unexpected ways resulting in the scrambling of sequences. In summary, MS-CPA not only provides a platform for rapid confirmation and annotation of tandem mass spectrometry data obtained with cyclic peptides but also enables quantitative analysis of the ion intensities. This program facilitates cyclic peptide analysis, sequencing, and also acts as a useful tool to investigate the uncommon fragmentation phenomena of cyclic peptides and aids the

  19. Synthesis of cyclic oligonucleotides by a modified phosphotriester approach.

    PubMed Central

    de Vroom, E; Broxterman, H J; Sliedregt, L A; van der Marel, G A; van Boom, J H

    1988-01-01

    Evidence will be presented to show that the allyl group is suitable for the protection of a 3'-terminal phosphodiester function. The latter will be demonstrated by the synthesis, via a phosphotriester approach, of two cyclic tetraribonucleotides [r(AAAA) and r(UAMe2UAMe2)], two cyclic hexadeoxyribonucleotides [d(CGCGCG) and d(TAAAAA)] and a cyclic octadeoxyribonucleotide [d(CGTGCGTG)]. PMID:3380690

  20. Quantum Dots

    NASA Astrophysics Data System (ADS)

    Tartakovskii, Alexander

    2012-07-01

    Part I. Nanostructure Design and Structural Properties of Epitaxially Grown Quantum Dots and Nanowires: 1. Growth of III/V semiconductor quantum dots C. Schneider, S. Hofling and A. Forchel; 2. Single semiconductor quantum dots in nanowires: growth, optics, and devices M. E. Reimer, N. Akopian, M. Barkelid, G. Bulgarini, R. Heeres, M. Hocevar, B. J. Witek, E. Bakkers and V. Zwiller; 3. Atomic scale analysis of self-assembled quantum dots by cross-sectional scanning tunneling microscopy and atom probe tomography J. G. Keizer and P. M. Koenraad; Part II. Manipulation of Individual Quantum States in Quantum Dots Using Optical Techniques: 4. Studies of the hole spin in self-assembled quantum dots using optical techniques B. D. Gerardot and R. J. Warburton; 5. Resonance fluorescence from a single quantum dot A. N. Vamivakas, C. Matthiesen, Y. Zhao, C.-Y. Lu and M. Atature; 6. Coherent control of quantum dot excitons using ultra-fast optical techniques A. J. Ramsay and A. M. Fox; 7. Optical probing of holes in quantum dot molecules: structure, symmetry, and spin M. F. Doty and J. I. Climente; Part III. Optical Properties of Quantum Dots in Photonic Cavities and Plasmon-Coupled Dots: 8. Deterministic light-matter coupling using single quantum dots P. Senellart; 9. Quantum dots in photonic crystal cavities A. Faraon, D. Englund, I. Fushman, A. Majumdar and J. Vukovic; 10. Photon statistics in quantum dot micropillar emission M. Asmann and M. Bayer; 11. Nanoplasmonics with colloidal quantum dots V. Temnov and U. Woggon; Part IV. Quantum Dot Nano-Laboratory: Magnetic Ions and Nuclear Spins in a Dot: 12. Dynamics and optical control of an individual Mn spin in a quantum dot L. Besombes, C. Le Gall, H. Boukari and H. Mariette; 13. Optical spectroscopy of InAs/GaAs quantum dots doped with a single Mn atom O. Krebs and A. Lemaitre; 14. Nuclear spin effects in quantum dot optics B. Urbaszek, B. Eble, T. Amand and X. Marie; Part V. Electron Transport in Quantum Dots Fabricated by

  1. May Cyclic Nucleotides Be a Source for Abiotic RNA Synthesis?

    NASA Astrophysics Data System (ADS)

    Costanzo, Giovanna; Pino, Samanta; Botta, Giorgia; Saladino, Raffaele; di Mauro, Ernesto

    2011-12-01

    Nucleic bases are obtained by heating formamide in the presence of various catalysts. Formamide chemistry also allows the formation of acyclonucleosides and the phosphorylation of nucleosides in every possible position, also affording 2',3' and 3',5' cyclic forms. We have reported that 3',5' cyclic GMP and 3',5' cyclic AMP polymerize in abiotic conditions yielding short oligonucleotides. The characterization of this reaction is being pursued, several of its parameters have been determined and experimental caveats are reported. The yield of non-enzymatic polymerization of cyclic purine nucleotides is very low. Polymerization is strongly enhanced by the presence of base-complementary RNA sequences.

  2. Dissipative quantum computing with open quantum walks

    SciTech Connect

    Sinayskiy, Ilya; Petruccione, Francesco

    2014-12-04

    An open quantum walk approach to the implementation of a dissipative quantum computing scheme is presented. The formalism is demonstrated for the example of an open quantum walk implementation of a 3 qubit quantum circuit consisting of 10 gates.

  3. Quantum Cryptography Without Quantum Uncertainties

    NASA Astrophysics Data System (ADS)

    Durt, Thomas

    2002-06-01

    Quantum cryptography aims at transmitting a random key in such a way that the presence of a spy eavesdropping the communication would be revealed by disturbances in the transmission of the message. In standard quantum cryptography, this unavoidable disturbance is a consequence of the uncertainty principle of Heisenberg. We propose in this paper to replace quantum uncertainties by generalised, technological uncertainties, and discuss the realisability of such an idea. The proposed protocol can be considered as a simplification, but also as a generalisation of the standard quantum cryptographic protocols.

  4. Quantum computer games: quantum minesweeper

    NASA Astrophysics Data System (ADS)

    Gordon, Michal; Gordon, Goren

    2010-07-01

    The computer game of quantum minesweeper is introduced as a quantum extension of the well-known classical minesweeper. Its main objective is to teach the unique concepts of quantum mechanics in a fun way. Quantum minesweeper demonstrates the effects of superposition, entanglement and their non-local characteristics. While in the classical minesweeper the goal of the game is to discover all the mines laid out on a board without triggering them, in the quantum version there are several classical boards in superposition. The goal is to know the exact quantum state, i.e. the precise layout of all the mines in all the superposed classical boards. The player can perform three types of measurement: a classical measurement that probabilistically collapses the superposition; a quantum interaction-free measurement that can detect a mine without triggering it; and an entanglement measurement that provides non-local information. The application of the concepts taught by quantum minesweeper to one-way quantum computing are also presented.

  5. Investigation of Cyclic Deformation and Fatigue of Polycrystalline Cu under Pure Compression Cyclic Loading Conditions

    NASA Astrophysics Data System (ADS)

    Hsu, Tzu-Yin Jean

    It is commonly accepted that fatigue crack is initiated under tensile fatigue stresses. However, practical examples demonstrate that cracks may initiate under pure compressive fluctuating loads, e.g. the failures observed in aircraft landing gear frames. As the mechanism of such failures is rarely investigated, there is very limited or non-existent knowledge pool on cyclic deformation response under pure compressive fatigue condition. Our recent work verified that fatigue cracks may nucleate from stress concentration sites under pure compression fatigue, but whether or not a form of stress concentration is always needed to initiate a crack remains uncertain. In this study, compression fatigue tests under different peak stresses were carried out on smooth bars of fully annealed OFHC Copper. The purpose of these tests is to investigate not only the cyclic deformation response but also the possibility of crack nucleation without the stress concentrator. Results showed that overall the cyclic stress-strain response and microstructural evolution of OFHC Copper under pure compression fatigue exhibits rather dissimilar behaviour compared to those under symmetrical fatigue. The specimens hardened rapidly within 10 cycles under pure compression fatigue unlike the gradual cyclic hardening behaviour in symmetrical fatigue with the same peak stress amplitude. Compressive cyclic creep behaviour was also observed. Moreover, TEM observation showed that only moderate slip activity was detectable on the surface instead of typical PSB features. The surface observations revealed that surface slip bands did not increase in number nor height as cycling progressed. In addition, surface roughening by grain boundary extrusion was detected to become more severe with further cycling. Therefore, the plastic strain accommodated within the samples was not mainly related to dislocation activities. Instead, the mechanism of cyclic creep response for pure compression fatigue was correlated and

  6. Quantum metrology

    NASA Technical Reports Server (NTRS)

    Lee, H.; Kok, P.; Dowling, J. P.

    2002-01-01

    This paper addresses the formal equivalence between the Mach-Zehnder interferometer, the Ramsey spectroscope, and a specific quantum logical gate. Based on this equivalence we introduce the quantum Rosetta Stone, and we describe a projective measurement scheme for generating the desired correlations between the interferometric input states in order to achieve Heisenberg-limited sensitivity.

  7. Quantum microbiology.

    PubMed

    Trevors, J T; Masson, L

    2011-01-01

    During his famous 1943 lecture series at Trinity College Dublin, the reknown physicist Erwin Schrodinger discussed the failure and challenges of interpreting life by classical physics alone and that a new approach, rooted in Quantum principles, must be involved. Quantum events are simply a level of organization below the molecular level. This includes the atomic and subatomic makeup of matter in microbial metabolism and structures, as well as the organic, genetic information code of DNA and RNA. Quantum events at this time do not elucidate, for example, how specific genetic instructions were first encoded in an organic genetic code in microbial cells capable of growth and division, and its subsequent evolution over 3.6 to 4 billion years. However, due to recent technological advances, biologists and physicists are starting to demonstrate linkages between various quantum principles like quantum tunneling, entanglement and coherence in biological processes illustrating that nature has exerted some level quantum control to optimize various processes in living organisms. In this article we explore the role of quantum events in microbial processes and endeavor to show that after nearly 67 years, Schrödinger was prophetic and visionary in his view of quantum theory and its connection with some of the fundamental mechanisms of life. PMID:21368338

  8. Cyclic Vomiting Presentations Following Marijuana Liberalization in Colorado

    PubMed Central

    Kim, Howard S.; Anderson, John D.; Saghafi, Omeed; Heard, Kennon J.; Monte, Andrew A.

    2015-01-01

    Objectives Case reports have described a syndrome of cyclic vomiting associated with chronic marijuana use, termed cannabinoid hyperemesis syndrome. The primary objective was to determine the prevalence of patients presenting with cyclic vomiting before and after the liberalization of medical marijuana in Colorado in 2009. The secondary objective was to describe the odds of marijuana use among cyclic vomiting visits in these same time periods. Methods This was a cross-sectional study of cyclic vomiting visits to the emergency department (ED) before and after marijuana liberalization. ED visits with International Classification of Diseases, ninth revision, coding for cyclic vomiting or that met diagnostic criteria for cyclic vomiting by the Rome III criteria were included. Results The authors reviewed 2,574 visits and identified 36 patients diagnosed with cyclic vomiting over 128 visits. The prevalence of cyclic vomiting visits increased from 41 per 113,262 ED visits to 87 per 125,095 ED visits after marijuana liberalization, corresponding to a prevalence ratio of 1.92 (95% confidence interval [CI] = 1.33 to 2.79). Patients with cyclic vomiting in the postliberalization period were more likely to have marijuana use documented than patients in the preliberalization period (odds ratio = 3.59, 95% CI = 1.44 to 9.00). Conclusions The prevalence of cyclic vomiting presentations nearly doubled after the liberalization of medical marijuana. Patients presenting with cyclic vomiting in the postliberalization period were more likely to endorse marijuana use, although it is unclear whether this was secondary to increased marijuana use, more accurate marijuana reporting, or both. PMID:25903855

  9. Quantum picturalism

    NASA Astrophysics Data System (ADS)

    Coecke, Bob

    2010-01-01

    Why did it take us 50 years since the birth of the quantum mechanical formalism to discover that unknown quantum states cannot be cloned? Yet, the proof of the 'no-cloning theorem' is easy, and its consequences and potential for applications are immense. Similarly, why did it take us 60 years to discover the conceptually intriguing and easily derivable physical phenomenon of 'quantum teleportation'? We claim that the quantum mechanical formalism doesn't support our intuition, nor does it elucidate the key concepts that govern the behaviour of the entities that are subject to the laws of quantum physics. The arrays of complex numbers are kin to the arrays of 0s and 1s of the early days of computer programming practice. Using a technical term from computer science, the quantum mechanical formalism is 'low-level'. In this review we present steps towards a diagrammatic 'high-level' alternative for the Hilbert space formalism, one which appeals to our intuition. The diagrammatic language as it currently stands allows for intuitive reasoning about interacting quantum systems, and trivialises many otherwise involved and tedious computations. It clearly exposes limitations such as the no-cloning theorem, and phenomena such as quantum teleportation. As a logic, it supports 'automation': it enables a (classical) computer to reason about interacting quantum systems, prove theorems, and design protocols. It allows for a wider variety of underlying theories, and can be easily modified, having the potential to provide the required step-stone towards a deeper conceptual understanding of quantum theory, as well as its unification with other physical theories. Specific applications discussed here are purely diagrammatic proofs of several quantum computational schemes, as well as an analysis of the structural origin of quantum non-locality. The underlying mathematical foundation of this high-level diagrammatic formalism relies on so-called monoidal categories, a product of a fairly

  10. COSP - A computer model of cyclic oxidation

    NASA Technical Reports Server (NTRS)

    Lowell, Carl E.; Barrett, Charles A.; Palmer, Raymond W.; Auping, Judith V.; Probst, Hubert B.

    1991-01-01

    A computer model useful in predicting the cyclic oxidation behavior of alloys is presented. The model considers the oxygen uptake due to scale formation during the heating cycle and the loss of oxide due to spalling during the cooling cycle. The balance between scale formation and scale loss is modeled and used to predict weight change and metal loss kinetics. A simple uniform spalling model is compared to a more complex random spall site model. In nearly all cases, the simpler uniform spall model gave predictions as accurate as the more complex model. The model has been applied to several nickel-base alloys which, depending upon composition, form Al2O3 or Cr2O3 during oxidation. The model has been validated by several experimental approaches. Versions of the model that run on a personal computer are available.

  11. Statistical cyclicity of the supercontinent cycle

    NASA Astrophysics Data System (ADS)

    Rolf, T.; Coltice, N.; Tackley, P. J.

    2014-04-01

    Supercontinents like Pangea impose a first-order control on Earth's evolution as they modulate global heat loss, sea level, climate, and biodiversity. In a traditional view, supercontinents form and break up in a regular, perhaps periodic, manner in a cycle lasting several 100 Myr as reflected in the assembly times of Earth's major continental aggregations: Columbia, Rodinia, and Pangea. However, modern views of the supercontinent cycle propose a more irregular evolution on the basis of an improved understanding of the Precambrian geologic record. Here we use fully dynamic spherical mantle convection models featuring plate-like behavior and continental drift to investigate supercontinent formation and breakup. We further dismiss the concept of regularity but suggest a statistical cyclicity in which the supercontinent cycle may have a characteristic period imposed by mantle and lithosphere properties, but this is hidden in immense fluctuations between different cycles that arise from the chaotic nature of mantle flow.

  12. Monitoring thermoplastic composites under cyclic bending tests

    NASA Astrophysics Data System (ADS)

    Boccardi, Simone; Meola, Carosena; Carlomagno, Giovanni Maria; Simeoli, Giorgio; Acierno, Domenico; Russo, Pietro

    2016-05-01

    This work is concerned with the use of infrared thermography to visualize temperature variations linked to thermo-elastic effects developing over the surface of a specimen undergoing deflection under bending tests. Several specimens are herein considered, which involve change of matrix and/or reinforcement. More specifically, the matrix is either a pure polypropylene, or a polypropylene added with a certain percentage of compatibilizing agent; the reinforcement is made of glass, or jute. Cyclic bending tests are carried out by the aid of an electromechanical actuator. Each specimen is viewed, during deflection, from one surface by an infrared imaging device. As main finding the different specimens display surface temperature variations which depend on the type of material in terms of both matrix and reinforcement.

  13. Stability of fuses under cyclic load

    NASA Astrophysics Data System (ADS)

    Namitokov, K. K.; Shklovskiy, I. G.

    1984-05-01

    Thermal stresses in fuses, stimulated by the high degree of mechanical stiffness and the cause of low stability under cyclic current loads, can be reduced by reducing the stiffness of the fuse element, which is typically a strap welded to contact caps at both ends. It is indicated that the stiffness can be reduced by increasing the length and decreasing the cross section. A thin strap consists of flat and bend segments. Simple bending and multiple bending were evaluated. It is indicated that bent fuse segments are less stiff than straight segments, that the relation between stiffness and amplitude of the bend is an inverse power law with the amplitude to a power much higher than squared, that the decrease of overall stiffness is approximately proportional to the number of bends, and that rectangular or circular bending reduce the stiffness most efficiently, inasmuch as such contours envelop the largest areas on the basis of fixed length.

  14. Cyclic steps incised on experimental bedrock

    NASA Astrophysics Data System (ADS)

    Yokokawa, M.; Kyogoku, A.; Kotera, A.; Izumi, N.

    2013-12-01

    In rivers flowing in mountain areas, a series of steps are often observed on bedrock. They are thought to be cyclic steps formed due to erosion of bedrock, which should be driven by abrasion due to bedload sediment transport. We demonstrated a series of flume experiments of the formation of cyclic steps on bedrock by abrasion due to bedload transportation using weak mortar as the model bedrock. We also compared the shapes of the steps reproduced in the experiments with those obtained in the analysis. The experiments were conducted using a 1.5 m long, 2 cm wide, and 20 cm deep flume made of glass in Osaka Institute of Technology. The flume has 10-cm-high weirs at both ends, so that there is a 10-cm-deep reservoir. We put mortar into the reservoir and hardened it. In order to make a highly erodible mortar, we casted the mortar with extremely low amount of cement. The ratio of cement, sand (0.2 mm in diameter), and water is x:150:50 (x ranges 1-3). The flume is tilted by 10 degrees. The water and colored sand is supplied from a head tank to the upstream end of the flume, flows on 'model bedrock' in the flume, and was dropped from the downstream end. We observed morphological changes of the surface of the bedrock by photos. We also used a laser displacement sensor to measure the surface topography of the 'model bedrock' before and after each run. The configuration of steps largely depends on the hardness of model bedrocks. In the case of the softest model bedrock (cement-sand-water ratio is 1:150:50) with small amount of sand, long-drawn potholes tend to be formed. Clear cyclic steps are formed on harder model bedrocks with large cement-sand-water ratios such as 2:150:50 and 3:150:50. When a series of steps are formed on the bed, typical wavelength and wave height are approximately 20 cm, and 2 - 3 cm, respectively. The general shape of a step is characterized by a relatively long downward-inclined slope just upstream of a short upward-inclined slope. The feature of

  15. Synthesis of N-substituted Cyclic Hydrocarbons, such as Pyrimidine, in The Ionosphere of Titan

    NASA Astrophysics Data System (ADS)

    Bera, P. P.; Peverati, R.; Head-Gordon, M.; Lee, T. J.

    2014-12-01

    The instruments on board the CASSINI spacecraft observed large carbonaceous molecules in the upper atmosphere of Titan. How these large polyatomic molecules are synthesized in such exotic conditions is, thus far, unknown. Molecular ions, including positive and negative ions, are in relative abundance in the ionosphere of Titan. Hence, barrierless ion-molecule interactions may play a major role in guiding molecules towards each other and initiating reactions. We study these condensation pathways to determine whether they are a viable means of forming large pure hydrocarbon molecules, and nitrogen-containing carbonaceous chains, stacks, and even cyclic compounds. By employing accurate quantum chemical methods we have investigated the processes of growth, structures, nature of bonding, mechanisms, and spectroscopic properties of the ensuing ionic products after pairing small carbon, hydrogen, and nitrogen-containing molecules with major ions observed in the upper atmosphere of Titan, e.g. C2H5+ and HCNH+. We have also studied the ion-neutral association pathways involving pure-carbon molecules e.g. acetylene, ethylene and other hydrocarbons, and their dissociation fragments in a plasma discharge. We have investigated how nitrogen atoms are incorporated into the carbon ring during growth. Specifically, we explored the mechanisms by which the synthesis of pyrimidine will be feasible in the atmosphere of Titan in conjunction with ion-mobility experiments. We have used accurate ab initio coupled cluster theory, Møller-Plesset perturbation theory, density functional theory, and coupled cluster theory quantum chemical methods together with large correlation consistent basis sets in these investigations. We found that a series of hydrocarbons with a specific stoichiometric composition prefers cyclic molecule formation rather than chains. Some of the association products we investigated have large oscillator strengths for charge-transfer type electronic excitations in the

  16. Globally synchronized oscillations in complex cyclic games

    NASA Astrophysics Data System (ADS)

    Rulquin, Charlotte; Arenzon, Jeferson J.

    2014-03-01

    The rock-paper-scissors game and its generalizations with S >3 species are well-studied models for cyclically interacting populations. Four is, however, the minimum number of species that, by allowing other interactions beyond the single, cyclic loop, breaks both the full intransitivity of the food graph and the one-predator, one-prey symmetry. Lütz et al. [J. Theor. Biol. 317, 286 (2013), 10.1016/j.jtbi.2012.10.024] have shown the existence, on a square lattice, of two distinct phases, with either four or three coexisting species. In both phases, each agent is eventually replaced by one of its predators, but these strategy oscillations remain localized as long as the interactions are short ranged. Distant regions may be either out of phase or cycling through different food-web subloops (if any). Here we show that upon replacing a minimum fraction Q of the short-range interactions by long-range ones, there is a Hopf bifurcation, and global oscillations become stable. Surprisingly, to build such long-distance, global synchronization, the four-species coexistence phase requires fewer long-range interactions than the three-species phase, while one would naively expect the opposite to be true. Moreover, deviations from highly homogeneous conditions (χ =0 or 1) increase Qc, and the more heterogeneous is the food web, the harder the synchronization is. By further increasing Q, while the three-species phase remains stable, the four-species one has a transition to an absorbing, single-species state. The existence of a phase with global oscillations for S >3, when the interaction graph has multiple subloops and several possible local cycles, leads to the conjecture that global oscillations are a general characteristic, even for large, realistic food webs.

  17. Presence of quantum correlations results in a nonvanishing ergotropic gap

    NASA Astrophysics Data System (ADS)

    Mukherjee, Amit; Roy, Arup; Bhattacharya, Some Sankar; Banik, Manik

    2016-05-01

    The paradigm of extracting work from an isolated quantum system through a cyclic Hamiltonian process is a topic of immense research interest. The optimal work extracted under such a process is termed ergotropy [Europhys. Lett. 67, 565 (2004)]. Here, in a multiparty scenario, we consider only a class of such cyclic processes that can be implemented locally, giving rise to the concept of local ergotropy. Eventually, the presence of quantum correlations results in a nonvanishing thermodynamic quantity called an ergotropic gap, measured by the difference between global and local ergotropy. However, the converse does not hold in general, i.e., its nonzero value does not necessarily imply the presence of quantum correlations. For arbitrary multiparty states, we quantify this gap. We also evaluate the difference between maximum global and local extractable work for arbitrary states when the system is no longer isolated but put in contact with a bath of the same local temperature.

  18. Theoretical Modeling of the Chirality Discrimination of Enantiomers by Nanotubular Cyclic Peptides using Gas-Phase Photoelectron Spectroscopy: An ONIOM Spectroscopic Calculations.

    PubMed

    Farrokhpour, H; Karachi, S; Chermahini, A Najafi

    2016-09-01

    In the present work, the chirality recognition of the enantiomers of a chiral molecule (1-phenyl-1-propanol) interacting with a nanotubular cyclic peptide (E-type cyclic decapeptide) was investigated by their ionization in the gas phase, theoretically. The absolute energy difference between the interaction of the S- and R-enantiomer with the cyclic peptide, calculated at the M06-2X/6-311++G(d, p) level of theory, was 4.70 kcal·mol(-1). Two different schemes of "Our own N-layered Integrated molecular Orbital and molecular Mechanics (ONIOM)" method such as (quantum mechanics (QM):molecular mechanics (MM)) and (QM:QM) were employed to study the effect of the interaction on the gas-phase ionization energies of the enantiomers and cyclic peptide, separately. The symmetry-adapted cluster/configuration interaction (SAC-CI) methodology was used for the calculation of the ionization energies. It was found that the difference between the interactions of R- and S-enantiomer with the cyclic peptide caused different changes in the photoelectron spectrum of each enantiomer so that these changes could be used for the chirality discrimination of the enantiomers in the gas phase. Similarly, the photoelectron spectrum of the cyclic peptide interacting with the R and S-enantiomer were calculated, separately, and it was observed that the difference in the interaction with the R- and S-enantiomer created different changes in the spectrum of cyclic peptide. Finally, it was shown that the difference in the interaction of cyclic peptide with the enantiomers of a chiral molecule in the gas phase can be used for the identification of enantiomers in the gas phase by the direct ionization. PMID:27500312

  19. Quantum Chaos

    NASA Astrophysics Data System (ADS)

    Casati, Giulio; Chirikov, Boris

    2006-11-01

    Preface; Acknowledgments; Introduction: 1. The legacy of chaos in quantum mechanics G. Casati and B. V. Chirikov; Part I. Classical Chaos and Quantum Localization: 2. Stochastic behaviour of a quantum pendulum under a periodic perturbation G. Casati, B. V. Chirikov, F. M. Izrailev and J. Ford; 3. Quantum dynamics of a nonintegrable system D. R. Grempel, R. E. Prange and S. E. Fishman; 4. Excitation of molecular rotation by periodic microwave pulses. A testing ground for Anderson localization R. Blümel, S. Fishman and U. Smilansky; 5. Localization of diffusive excitation in multi-level systems D. K. Shepelyansky; 6. Classical and quantum chaos for a kicked top F. Haake, M. Kus and R. Scharf; 7. Self-similarity in quantum dynamics L. E. Reichl and L. Haoming; 8. Time irreversibility of classically chaotic quantum dynamics K. Ikeda; 9. Effect of noise on time-dependent quantum chaos E. Ott, T. M. Antonsen Jr and J. D. Hanson; 10. Dynamical localization, dissipation and noise R. F. Graham; 11. Maximum entropy models and quantum transmission in disordered systems J.-L. Pichard and M. Sanquer; 12. Solid state 'atoms' in intense oscillating fields M. S. Sherwin; Part II. Atoms in Strong Fields: 13. Localization of classically chaotic diffusion for hydrogen atoms in microwave fields J. E. Bayfield, G. Casati, I. Guarneri and D. W. Sokol; 14. Inhibition of quantum transport due to 'scars' of unstable periodic orbits R. V. Jensen, M. M. Sanders, M. Saraceno and B. Sundaram; 15. Rubidium Rydberg atoms in strong fields G. Benson, G. Raithel and H. Walther; 16. Diamagnetic Rydberg atom: confrontation of calculated and observed spectra C.-H. Iu, G. R. Welch, M. M. Kash, D. Kleppner, D. Delande and J. C. Gay; 17. Semiclassical approximation for the quantum states of a hydrogen atom in a magnetic field near the ionization limit M. Y. Kuchiev and O. P. Sushkov; 18. The semiclassical helium atom D. Wintgen, K. Richter and G. Tanner; 19. Stretched helium: a model for quantum chaos

  20. Quantum Chaos

    NASA Astrophysics Data System (ADS)

    Casati, Giulio; Chirikov, Boris

    1995-04-01

    Preface; Acknowledgments; Introduction: 1. The legacy of chaos in quantum mechanics G. Casati and B. V. Chirikov; Part I. Classical Chaos and Quantum Localization: 2. Stochastic behaviour of a quantum pendulum under a periodic perturbation G. Casati, B. V. Chirikov, F. M. Izrailev and J. Ford; 3. Quantum dynamics of a nonintegrable system D. R. Grempel, R. E. Prange and S. E. Fishman; 4. Excitation of molecular rotation by periodic microwave pulses. A testing ground for Anderson localization R. Blümel, S. Fishman and U. Smilansky; 5. Localization of diffusive excitation in multi-level systems D. K. Shepelyansky; 6. Classical and quantum chaos for a kicked top F. Haake, M. Kus and R. Scharf; 7. Self-similarity in quantum dynamics L. E. Reichl and L. Haoming; 8. Time irreversibility of classically chaotic quantum dynamics K. Ikeda; 9. Effect of noise on time-dependent quantum chaos E. Ott, T. M. Antonsen Jr and J. D. Hanson; 10. Dynamical localization, dissipation and noise R. F. Graham; 11. Maximum entropy models and quantum transmission in disordered systems J.-L. Pichard and M. Sanquer; 12. Solid state 'atoms' in intense oscillating fields M. S. Sherwin; Part II. Atoms in Strong Fields: 13. Localization of classically chaotic diffusion for hydrogen atoms in microwave fields J. E. Bayfield, G. Casati, I. Guarneri and D. W. Sokol; 14. Inhibition of quantum transport due to 'scars' of unstable periodic orbits R. V. Jensen, M. M. Sanders, M. Saraceno and B. Sundaram; 15. Rubidium Rydberg atoms in strong fields G. Benson, G. Raithel and H. Walther; 16. Diamagnetic Rydberg atom: confrontation of calculated and observed spectra C.-H. Iu, G. R. Welch, M. M. Kash, D. Kleppner, D. Delande and J. C. Gay; 17. Semiclassical approximation for the quantum states of a hydrogen atom in a magnetic field near the ionization limit M. Y. Kuchiev and O. P. Sushkov; 18. The semiclassical helium atom D. Wintgen, K. Richter and G. Tanner; 19. Stretched helium: a model for quantum chaos

  1. Advanced Developments in Cyclic Polymers: Synthesis, Applications, and Perspectives

    PubMed Central

    Zhu, Yinghuai; Hosmane, Narayan S

    2015-01-01

    Due to the topological effect, cyclic polymers demonstrate different and unique physical and biological properties in comparison with linear counterparts having the same molecular-weight range. With advanced synthetic and analytic technologies, cyclic polymers with different topologies, e.g. multicyclic polymers, have been reported and well characterized. For example, various cyclic DNA and related structures, such as cyclic duplexes, have been prepared conveniently by click chemistry. These types of DNA have increased resistance to enzymatic degradation and have high thermodynamic stability, and thus, have potential therapeutic applications. In addition, cyclic polymers have also been used to prepare organic–inorganic hybrids for applications in catalysis, e.g. catalyst supports. Due to developments in synthetic technology, highly pure cyclic polymers could now be produced in large scale. Therefore, we anticipate discovering more applications in the near future. Despite their promise, cyclic polymers are still less explored than linear polymers like polyolefins and polycarbonates, which are widely used in daily life. Some critical issues, including controlling the molecular weight and finding suitable applications, remain big challenges in the cyclic-polymer field. This review briefly summarizes the commonly used synthetic methodologies and focuses more on the attractive functional materials and their biological properties and potential applications. PMID:26478835

  2. Dietary cyclic dipeptides, apoptosis and psychiatric disorders: a hypothesis.

    PubMed

    Semon, Bruce A

    2014-06-01

    Cyclic dipeptides from food and intestinal yeast cyclic dipeptides may play a role in causing psychiatric disorders such as schizophrenia. From cancer research, cyclic dipeptides such as cyclo (proline-phenylalanine) have been found to activate the pathways of apoptosis and to cause programmed cell death. Activation of such pathways is also thought to be important in causing the neurodevelopmental abnormalities seen in disorders such as schizophrenia and autistic disorder, and also may be important in Alzheimer's. Cyclic dipeptides are found in foods such as malt and cocoa and beer. The intestinal yeast Candida albicans also synthesizes cyclic dipeptides. These dipeptides may be activating apoptosis pathways throughout fetal development and postnatal development, leading to some of the changes seen in brain in schizophrenia and in other psychiatric disorders. These compounds should be researched further to see if they play a role in causing these brain changes. In addition, these cyclic dipeptides are considered within the larger context of research on amino acids and other cyclic dipeptides in neurotransmission and neurophysiology. A better understanding of the role of these cyclic dipeptides in psychiatric disorders could lead to strategies for prevention and treatment of these disorders. PMID:24717821

  3. MICROWAVE-ASSISTED PREPARATION OF CYCLIC UREAS FROM DIAMINES

    EPA Science Inventory

    Rajender S. Varma* and Yong-Jin Kim
    Cyclic ureas are useful intermediates for a variety of pharmaceuticals and pesticides. One of the attractive approaches for the synthesis of cyclic ureas uses condensation of diamines with urea as a carbonyl source under dynamic evacuation. ...

  4. High-Temperature Cyclic Oxidation Data, Volume 1

    NASA Technical Reports Server (NTRS)

    Barrett, C. A.; Garlick, R. G.; Lowell, C. E.

    1984-01-01

    This first in a series of cyclic oxidation handbooks contains specific-weight-change-versus-time data and X-ray diffraction results derived from high-temperature cyclic tests on high-temperature, high-strength nickel-base gamma/gamma' and cobalt-base turbine alloys. Each page of data summarizes a complete test on a given alloy sample.

  5. Quantum strategies of quantum measurements

    NASA Astrophysics Data System (ADS)

    Li, Chuan-Feng; Zhang, Yong-Sheng; Huang, Yun-Feng; Guo, Guang-Can

    2001-03-01

    In the classical Monty Hall problem, one player can always win with probability 2/3. We generalize the problem to the quantum domain and show that a fair two-party zero-sum game can be carried out if the other player is permitted to adopt quantum measurement strategy.

  6. Sequencing by Cyclic Ligation and Cleavage (CycLiC) directly on a microarray captured template

    PubMed Central

    Mir, Kalim U.; Qi, Hong; Salata, Oleg; Scozzafava, Giuseppe

    2009-01-01

    Next generation sequencing methods that can be applied to both the resequencing of whole genomes and to the selective resequencing of specific parts of genomes are needed. We describe (i) a massively scalable biochemistry, Cyclical Ligation and Cleavage (CycLiC) for contiguous base sequencing and (ii) apply it directly to a template captured on a microarray. CycLiC uses four color-coded DNA/RNA chimeric oligonucleotide libraries (OL) to extend a primer, a base at a time, along a template. The cycles comprise the steps: (i) ligation of OLs, (ii) identification of extended base by label detection, and (iii) cleavage to remove label/terminator and undetermined bases. For proof-of-principle, we show that the method conforms to design and that we can read contiguous bases of sequence correctly from a template captured by hybridization from solution to a microarray probe. The method is amenable to massive scale-up, miniaturization and automation. Implementation on a microarray format offers the potential for both selection and sequencing of a large number of genomic regions on a single platform. Because the method uses commonly available reagents it can be developed further by a community of users. PMID:19015154

  7. Ground-state information geometry and quantum criticality in an inhomogeneous spin model

    NASA Astrophysics Data System (ADS)

    Ma, Yu-Quan

    2015-09-01

    We investigate the ground-state Riemannian metric and the cyclic quantum distance of an inhomogeneous quantum spin-1/2 chain in a transverse field. This model can be diagonalized by using a general canonical transformation to the fermionic Hamiltonian mapped from the spin system. The ground-state Riemannian metric is derived exactly on a parameter manifold ring S1, which is introduced by performing a gauge transformation to the spin Hamiltonian through a twist operator. The cyclic ground-state quantum distance and the second derivative of the ground-state energy are studied in different exchange coupling parameter regions. Particularly, we show that, in the case of exchange coupling parameter Ja = Jb, the quantum ferromagnetic phase can be characterized by an invariant quantum distance and this distance will decay to zero rapidly in the paramagnetic phase. Project supported by the National Natural Science Foundation of China (Grant Nos. 11404023 and 11347131).

  8. Spatial Non-Cyclic Geometric Phase in Neutron Interferometry

    PubMed Central

    Filipp, Stefan; Hasegawa, Yuji; Loidl, Rudolf; Rauch, Helmut

    2005-01-01

    We present a split-beam neutron interferometric experiment to test the non-cyclic geometric phase tied to the spatial evolution of the system: the subjacent two-dimensional Hilbert space is spanned by the two possible paths in the interferometer and the evolution of the state is controlled by phase shifters and absorbers. A related experiment was reported previously by some of the authors to verify the cyclic spatial geometric phase. The interpretation of this experiment, namely to ascribe a geometric phase to this particular state evolution, has met severe criticism. The extension to non-cyclic evolution manifests the correctness of the interpretation of the previous experiment by means of an explicit calculation of the non-cyclic geometric phase in terms of paths on the Bloch-sphere. The theoretical treatment comprises the cyclic geometric phase as a special case, which is confirmed by experiment. PMID:27308131

  9. Automated mass spectrometric sequence determination of cyclic peptide library members.

    PubMed

    Redman, James E; Wilcoxen, Keith M; Ghadiri, M Reza

    2003-01-01

    Cyclic peptides have come under scrutiny as potential antimicrobial therapeutic agents. Combinatorial split-and-pool synthesis of cyclic peptides can afford single compound per well libraries for antimicrobial screening, new lead identification, and construction of quantitative structure-activity relationships (QSAR). Here, we report a new sequencing protocol for rapid identification of the members of a cyclic peptide library based on automated computer analysis of mass spectra, obviating the need for library encoding/decoding strategies. Furthermore, the software readily integrates with common spreadsheet and database packages to facilitate data visualization and archiving. The utility of the new MS-sequencing approach is demonstrated using sonic spray ionization ion trap MS and MS/MS spectrometry on a single compound per bead cyclic peptide library and validated with individually synthesized pure cyclic D,L-alpha-peptides. PMID:12523832

  10. Quantum Pendulum.

    ERIC Educational Resources Information Center

    Aldrovandi, R.: Ferreira, P. Leal

    1980-01-01

    Discusses the problem of the mathematical pendulum in its classical, semiclassical, and quantum aspects. The energy spectrum and its eigenfunctions are presented under the usual requirement of single valuedness of the solutions. (Author/CS)

  11. Quantum Heterostructures

    NASA Astrophysics Data System (ADS)

    Mitin, Vladimir; Kochelap, Viacheslav; Stroscio, Michael A.

    1999-07-01

    Quantum Heterostructures provides a detailed description of the key physical and engineering principles of quantum semiconductor heterostructures. Blending important concepts from physics, materials science, and electrical engineering, it also explains clearly the behavior and operating features of modern microelectronic and optoelectronic devices. The authors begin by outlining the trends that have driven development in this field, most importantly the need for high-performance devices in computer, information, and communications technologies. They then describe the basics of quantum nanoelectronics, including various transport mechanisms. In the latter part of the book, they cover novel microelectronic devices, and optical devices based on quantum heterostructures. The book contains many homework problems and is suitable as a textbook for undergraduate and graduate courses in electrical engineering, physics, or materials science. It will also be of great interest to those involved in research or development in microelectronic or optoelectronic devices.

  12. Quantum Locality?

    NASA Astrophysics Data System (ADS)

    Stapp, Henry P.

    2012-05-01

    Robert Griffiths has recently addressed, within the framework of a `consistent quantum theory' that he has developed, the issue of whether, as is often claimed, quantum mechanics entails a need for faster-than-light transfers of information over long distances. He argues that the putative proofs of this property that involve hidden variables include in their premises some essentially classical-physics-type assumptions that are not entailed by the precepts of quantum mechanics. Thus whatever is proved is not a feature of quantum mechanics, but is a property of a theory that tries to combine quantum theory with quasi-classical features that go beyond what is entailed by quantum theory itself. One cannot logically prove properties of a system by establishing, instead, properties of a system modified by adding properties alien to the original system. Hence Griffiths' rejection of hidden-variable-based proofs is logically warranted. Griffiths mentions the existence of a certain alternative proof that does not involve hidden variables, and that uses only macroscopically described observable properties. He notes that he had examined in his book proofs of this general kind, and concluded that they provide no evidence for nonlocal influences. But he did not examine the particular proof that he cites. An examination of that particular proof by the method specified by his `consistent quantum theory' shows that the cited proof is valid within that restrictive version of quantum theory. An added section responds to Griffiths' reply, which cites general possibilities of ambiguities that might make what is to be proved ill-defined, and hence render the pertinent `consistent framework' ill defined. But the vagaries that he cites do not upset the proof in question, which, both by its physical formulation and by explicit identification, specify the framework to be used. Griffiths confirms the validity of the proof insofar as that pertinent framework is used. The section also shows

  13. Quantum correlations and distinguishability of quantum states

    SciTech Connect

    Spehner, Dominique

    2014-07-15

    A survey of various concepts in quantum information is given, with a main emphasis on the distinguishability of quantum states and quantum correlations. Covered topics include generalized and least square measurements, state discrimination, quantum relative entropies, the Bures distance on the set of quantum states, the quantum Fisher information, the quantum Chernoff bound, bipartite entanglement, the quantum discord, and geometrical measures of quantum correlations. The article is intended both for physicists interested not only by collections of results but also by the mathematical methods justifying them, and for mathematicians looking for an up-to-date introductory course on these subjects, which are mainly developed in the physics literature.

  14. Targeting Cyclic Nucleotide Phosphodiesterase in the Heart: Therapeutic Implications

    PubMed Central

    Miller, Clint L.

    2010-01-01

    The second messengers, cAMP and cGMP, regulate a number of physiological processes in the myocardium, from acute contraction/relaxation to chronic gene expression and cardiac structural remodeling. Emerging evidence suggests that multiple spatiotemporally distinct pools of cyclic nucleotides can discriminate specific cellular functions from a given cyclic nucleotide-mediated signal. Cyclic nucleotide phosphodiesterases (PDEs), by hydrolyzing intracellular cyclic AMP and/or cyclic GMP, control the amplitude, duration, and compartmentation of cyclic nucleotide signaling. To date, more than 60 different isoforms have been described and grouped into 11 broad families (PDE1–PDE11) based on differences in their structure, kinetic and regulatory properties, as well as sensitivity to chemical inhibitors. In the heart, PDE isozymes from at least six families have been investigated. Studies using selective PDE inhibitors and/or genetically manipulated animals have demonstrated that individual PDE isozymes play distinct roles in the heart by regulating unique cyclic nucleotide signaling microdomains. Alterations of PDE activity and/or expression have also been observed in various cardiac disease models, which may contribute to disease progression. Several family-selective PDE inhibitors have been used clinically or pre-clinically for the treatment of cardiac or vascular-related diseases. In this review, we will highlight both recent advances and discrepancies relevant to cardiovascular PDE expression, pathophysiological function, and regulation. In particular, we will emphasize how these properties influence current and future development of PDE inhibitors for the treatment of pathological cardiac remodeling and dysfunction. PMID:20632220

  15. Phorbol esters modulate cyclic AMP accumulation in porcine thyroid cells

    SciTech Connect

    Emoto, T.; Kasai, K.; Hiraiwa, M.; Shimoda, S.

    1988-01-01

    In cultured porcine thyroid cells, during 60 min incubation phorbol 12-myristate 13-acetate (PMA) had no effect on basal cyclic AMP accumulation and slightly stimulated cyclic AMP accumulation evoked by thyroid stimulating hormone (TSH) or forskolin. Cholera toxin-induced cyclic AMP accumulation was significantly stimulated by PMA. On the other hand, cyclic AMP accumulation evoked by prostaglandin E/sub 1/ or E/sub 2/ (PGE/sub 1/ and PGE/sub 2/) was markedly depressed by simultaneous addition of PMA. These opposing effects of PMA on cyclic AMP accumulation evoked by PGE and cholera toxin were observed in a dose-related fashion, with half-maximal effect of around 10/sup -9/ M in either case. The almost same effects of PMA on cyclic AMP accumulation in basal and stimulated conditions were also observed in freshly prepared thyroid cells. The present study was performed in the presence of phosphodiesterase inhibitor, 3-iso-butyl-1-methylxanthine (IBMX), indicating that PMA affected adenylate cyclase activity. Therefore, it is suggested that PMA may modulate the production of cyclic AMP in response to different stimuli, possibly by affecting several sites in the adenylate cyclase complex in thyroid cells.

  16. Cyclic AMP-dependent protein kinase activity in Trypanosoma cruzi.

    PubMed Central

    Ulloa, R M; Mesri, E; Esteva, M; Torres, H N; Téllez-Iñón, M T

    1988-01-01

    A cyclic AMP-dependent protein kinase activity from epimastigote forms of Trypanosoma cruzi was characterized. Cytosolic extracts were chromatographed on DEAE-cellulose columns, giving two peaks of kinase activity, which were eluted at 0.15 M- and 0.32 M-NaCl respectively. The second activity peak was stimulated by nanomolar concentrations of cyclic AMP. In addition, a cyclic AMP-binding protein co-eluted with the second kinase activity peak. Cyclic AMP-dependent protein kinase activity was further purified by gel filtration, affinity chromatography on histone-agarose and cyclic AMP-agarose, as well as by chromatography on CM-Sephadex. The enzyme ('holoenzyme') could be partially dissociated into two different components: 'catalytic' and 'regulatory'. The 'regulatory' component had specific binding for cyclic AMP, and it inhibited phosphotransferase activity of the homologous 'catalytic component' or of the 'catalytic subunit' from bovine heart. Cyclic AMP reversed these inhibitions. A 'holoenzyme preparation' was phosphorylated in the absence of exogenous phosphate acceptor and analysed by polyacrylamide-gel electrophoresis. A 56 kDa band was phosphorylated. The same preparation was analysed by Western blotting, by using polyclonal antibodies to the regulatory subunits of protein kinases type I or II. Both antibodies reacted with the 56 kDa band. Images Fig. 7. Fig. 8. PMID:2848508

  17. Collagen network strengthening following cyclic tensile loading.

    PubMed

    Susilo, Monica E; Paten, Jeffrey A; Sander, Edward A; Nguyen, Thao D; Ruberti, Jeffrey W

    2016-02-01

    The bulk mechanical properties of tissues are highly tuned to the physiological loads they experience and reflect the hierarchical structure and mechanical properties of their constituent parts. A thorough understanding of the processes involved in tissue adaptation is required to develop multi-scale computational models of tissue remodelling. While extracellular matrix (ECM) remodelling is partly due to the changing cellular metabolic activity, there may also be mechanically directed changes in ECM nano/microscale organization which lead to mechanical tuning. The thermal and enzymatic stability of collagen, which is the principal load-bearing biopolymer in vertebrates, have been shown to be enhanced by force suggesting that collagen has an active role in ECM mechanical properties. Here, we ask how changes in the mechanical properties of a collagen-based material are reflected by alterations in the micro/nanoscale collagen network following cyclic loading. Surprisingly, we observed significantly higher tensile stiffness and ultimate tensile strength, roughly analogous to the effect of work hardening, in the absence of network realignment and alterations to the fibril area fraction. The data suggest that mechanical loading induces stabilizing changes internal to the fibrils themselves or in the fibril-fibril interactions. If such a cell-independent strengthening effect is operational in vivo, then it would be an important consideration in any multiscale computational approach to ECM growth and remodelling. PMID:26855760

  18. Hot embossing of cyclic olefin copolymers

    NASA Astrophysics Data System (ADS)

    Leech, P. W.

    2009-05-01

    The hot embossing properties of cyclic olefin copolymer (COC) have been examined as a function of comonomer content. Six standard grades of COC with varying norbornene content (61-82 wt%) were used in these experiments in order to provide a range of glass transition temperatures, Tg. All grades of COC exhibited sharp increases in embossed depth over a critical range of temperature. The transition temperature in embossed depth increased linearly with norbornene content for both 35 and 70 µm deep structures. At temperatures above this transition, the dimensions of the embossed patterns were essentially independent of the COC grade, the applied pressure and duration of loading. Channels formed above the transition in a regime of viscous liquid flow were extremely smooth in morphology for all grades. The average surface roughness, Ra, measured at the base of the channels decreased sharply at the transition temperature, with a levelling off at higher temperatures. Grades of COC with a higher norbornene content exhibited extensive micro-cracking during embossing at temperatures close to the transition temperature.

  19. Cyclic Game Dynamics Driven by Iterated Reasoning

    PubMed Central

    Frey, Seth; Goldstone, Robert L.

    2013-01-01

    Recent theories from complexity science argue that complex dynamics are ubiquitous in social and economic systems. These claims emerge from the analysis of individually simple agents whose collective behavior is surprisingly complicated. However, economists have argued that iterated reasoning–what you think I think you think–will suppress complex dynamics by stabilizing or accelerating convergence to Nash equilibrium. We report stable and efficient periodic behavior in human groups playing the Mod Game, a multi-player game similar to Rock-Paper-Scissors. The game rewards subjects for thinking exactly one step ahead of others in their group. Groups that play this game exhibit cycles that are inconsistent with any fixed-point solution concept. These cycles are driven by a “hopping” behavior that is consistent with other accounts of iterated reasoning: agents are constrained to about two steps of iterated reasoning and learn an additional one-half step with each session. If higher-order reasoning can be complicit in complex emergent dynamics, then cyclic and chaotic patterns may be endogenous features of real-world social and economic systems. PMID:23441191

  20. Cyclicity of some symmetric nilpotent centers

    NASA Astrophysics Data System (ADS)

    García, Isaac A.

    2016-03-01

    In this work we present techniques for bounding the cyclicity of a wide class of monodromic nilpotent singularities of symmetric polynomial planar vector fields. The starting point is identifying a broad family of nilpotent symmetric fields for which existence of a center is equivalent to existence of a local analytic first integral, which, unlike the degenerate case, is not true in general for nilpotent singularities. We are able to relate so-called "focus quantities" to the "Poincaré-Lyapunov quantities" arising from the Poincaré first return map. When we apply the method to concrete examples, we show in some cases that the upper bound is sharp. Our approach is based on computational algebra methods for determining a minimal basis (constructed by focus quantities instead of by Poincaré-Lyapunov quantities because of the easier computability of the former) of the associated polynomial Bautin ideal in the parameter space of the family. The case in which the Bautin ideal is not radical is also treated.

  1. Cyclic Vomiting Syndrome: A Functional Disorder

    PubMed Central

    Kaul, Kanwar K.

    2015-01-01

    Cyclic vomiting syndrome (CVS) is a functional disorder characterized by stereotypical episodes of intense vomiting separated by weeks to months. Although it can occur at any age, the most common age at presentation is 3-7 years. There is no gender predominance. The precise pathophysiology of CVS is not known but a strong association with migraine headaches, in the patient as well as the mother indicates that it may represent a mitochondriopathy. Studies have also suggested the role of an underlying autonomic neuropathy involving the sympathetic nervous system in its pathogenesis. CVS has known triggers in many individuals and avoiding these triggers can help prevent the onset of the episodes. It typically presents in four phases: a prodrome, vomiting phase, recovery phase and an asymptomatic phase until the next episode. Complications such as dehydration and hematemesis from Mallory Wise tear of the esophageal mucosa may occur in more severe cases. Blood and urine tests and abdominal imaging may be indicated depending upon the severity of symptoms. Brain magnetic resonance imaging and upper gastrointestinal endoscopy may also be indicated in certain circumstances. Management of an episode after it has started ('abortive treatment') includes keeping the patient in a dark and quiet room, intravenous hydration, ondansetron, sumatriptan, clonidine, and benzodiazepines. Prophylactic treatment includes cyproheptadine, propranolol and amitriptyline. No mortality has been reported as a direct result of CVS and many children outgrow it over time. A subset may develop other functional disorders like irritable bowel syndrome and migraine headaches. PMID:26770896

  2. Cyclic Vomiting Syndrome: A Functional Disorder.

    PubMed

    Kaul, Ajay; Kaul, Kanwar K

    2015-12-01

    Cyclic vomiting syndrome (CVS) is a functional disorder characterized by stereotypical episodes of intense vomiting separated by weeks to months. Although it can occur at any age, the most common age at presentation is 3-7 years. There is no gender predominance. The precise pathophysiology of CVS is not known but a strong association with migraine headaches, in the patient as well as the mother indicates that it may represent a mitochondriopathy. Studies have also suggested the role of an underlying autonomic neuropathy involving the sympathetic nervous system in its pathogenesis. CVS has known triggers in many individuals and avoiding these triggers can help prevent the onset of the episodes. It typically presents in four phases: a prodrome, vomiting phase, recovery phase and an asymptomatic phase until the next episode. Complications such as dehydration and hematemesis from Mallory Wise tear of the esophageal mucosa may occur in more severe cases. Blood and urine tests and abdominal imaging may be indicated depending upon the severity of symptoms. Brain magnetic resonance imaging and upper gastrointestinal endoscopy may also be indicated in certain circumstances. Management of an episode after it has started ('abortive treatment') includes keeping the patient in a dark and quiet room, intravenous hydration, ondansetron, sumatriptan, clonidine, and benzodiazepines. Prophylactic treatment includes cyproheptadine, propranolol and amitriptyline. No mortality has been reported as a direct result of CVS and many children outgrow it over time. A subset may develop other functional disorders like irritable bowel syndrome and migraine headaches. PMID:26770896

  3. Cyclic oxidation evaluation - Approaching application conditions.

    NASA Technical Reports Server (NTRS)

    Barrett, C. A.; Evans, E. B.

    1973-01-01

    Review of 1000 to 1200 C cyclic oxidation testing conducted on potential aircraft gas turbine Ni-, Co-, and Fe-base alloys. Furnace and burner rig testing are discussed, and the results are compared for selected alloys. The alloys fall into two groups, depending on their Cr and Al contents. One group forms mainly Cr2O3/chromite spinel scale(s), while the other forms alpha Al2O3/aluminate spinel scale(s). Spalling on thermal cycling leading to increased metal consumption is associated with the appearance of a chromite spinel. In the case of high-velocity burner rig tests this chromite forming tendency is reinforced by Cr2O3 vaporization depleting Cr in the alloy. In both types of tests, specific weight change is used as an indirect indicator of metal attack, since direct metal loss measurements require destructive analysis. An alternative nondestructive metal loss estimating parameter, based on a tentative mass balance gravimetric approach, shows some potential.

  4. Cyclic flow underground coal gasification process

    DOEpatents

    Bissett, Larry A.

    1978-01-01

    The present invention is directed to a method of in situ coal gasification for providing the product gas with an enriched concentration of carbon monoxide. The method is practiced by establishing a pair of combustion zones in spaced-apart boreholes within a subterranean coal bed and then cyclically terminating the combustion in the first of the two zones to establish a forward burn in the coal bed so that while an exothermic reaction is occurring in the second combustion zone to provide CO.sub.2 -laden product gas, an endothermic CO-forming reaction is occurring in the first combustion zone between the CO.sub.2 -laden gas percolating thereinto and the hot carbon in the wall defining the first combustion zone to increase the concentration of CO in the product gas. When the endothermic reaction slows to a selected activity the roles of the combustion zones are reversed by re-establishing an exothermic combustion reaction in the first zone and terminating the combustion in the second zone.

  5. Copper regulates cyclic-AMP-dependent lipolysis.

    PubMed

    Krishnamoorthy, Lakshmi; Cotruvo, Joseph A; Chan, Jefferson; Kaluarachchi, Harini; Muchenditsi, Abigael; Pendyala, Venkata S; Jia, Shang; Aron, Allegra T; Ackerman, Cheri M; Wal, Mark N Vander; Guan, Timothy; Smaga, Lukas P; Farhi, Samouil L; New, Elizabeth J; Lutsenko, Svetlana; Chang, Christopher J

    2016-08-01

    Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as sodium, potassium, calcium and zinc, but their redox-active transition metal counterparts such as copper and iron have been studied primarily as static enzyme cofactors. Here we report that copper is an endogenous regulator of lipolysis, the breakdown of fat, which is an essential process in maintaining body weight and energy stores. Using a mouse model of genetic copper misregulation, in combination with pharmacological alterations in copper status and imaging studies in a 3T3-L1 white adipocyte model, we found that copper regulates lipolysis at the level of the second messenger, cyclic AMP (cAMP), by altering the activity of the cAMP-degrading phosphodiesterase PDE3B. Biochemical studies of the copper-PDE3B interaction establish copper-dependent inhibition of enzyme activity and identify a key conserved cysteine residue in a PDE3-specific loop that is essential for the observed copper-dependent lipolytic phenotype. PMID:27272565

  6. A low-power arcjet cyclic lifetest

    NASA Technical Reports Server (NTRS)

    Curran, Francis M.; Hardy, Terry L.; Haag, Thomas W.

    1987-01-01

    A cyclic lifetest of a low power dc arcjet thruster using a hydrogen/nitrogen propellant mixture simulating hydrazine is currently in progress. Over 300 hr of operation have been accumulated to date in 2 hr duty cycles at a power level of about 1.15 kW, approximating that available on commercial communications satellites. A burn-in period was carried out before consistent operation was attained. After this period, the arcjet operated in a very stable fashion from cycle to cycle. At the beginning of each cycle, there was a brief starting transient followed by a rapid rise to a steady-state voltage. The steady-state voltage increased by about 5 V over the first 95 cycles. After this, it increased by only 1 V through the remainder of the test. Thrust measurements taken before the life test and again after the completion of the 144th cycle showed that both thrust, specific impulse, and arc voltage had increased over this period of operation. No life limiting mechanisms were observed during the course of the testing.

  7. Automated Search for new Quantum Experiments

    NASA Astrophysics Data System (ADS)

    Krenn, Mario; Malik, Mehul; Fickler, Robert; Lapkiewicz, Radek; Zeilinger, Anton

    2016-03-01

    Quantum mechanics predicts a number of, at first sight, counterintuitive phenomena. It therefore remains a question whether our intuition is the best way to find new experiments. Here, we report the development of the computer algorithm Melvin which is able to find new experimental implementations for the creation and manipulation of complex quantum states. Indeed, the discovered experiments extensively use unfamiliar and asymmetric techniques which are challenging to understand intuitively. The results range from the first implementation of a high-dimensional Greenberger-Horne-Zeilinger state, to a vast variety of experiments for asymmetrically entangled quantum states—a feature that can only exist when both the number of involved parties and dimensions is larger than 2. Additionally, new types of high-dimensional transformations are found that perform cyclic operations. Melvin autonomously learns from solutions for simpler systems, which significantly speeds up the discovery rate of more complex experiments. The ability to automate the design of a quantum experiment can be applied to many quantum systems and allows the physical realization of quantum states previously thought of only on paper.

  8. Automated Search for new Quantum Experiments.

    PubMed

    Krenn, Mario; Malik, Mehul; Fickler, Robert; Lapkiewicz, Radek; Zeilinger, Anton

    2016-03-01

    Quantum mechanics predicts a number of, at first sight, counterintuitive phenomena. It therefore remains a question whether our intuition is the best way to find new experiments. Here, we report the development of the computer algorithm Melvin which is able to find new experimental implementations for the creation and manipulation of complex quantum states. Indeed, the discovered experiments extensively use unfamiliar and asymmetric techniques which are challenging to understand intuitively. The results range from the first implementation of a high-dimensional Greenberger-Horne-Zeilinger state, to a vast variety of experiments for asymmetrically entangled quantum states-a feature that can only exist when both the number of involved parties and dimensions is larger than 2. Additionally, new types of high-dimensional transformations are found that perform cyclic operations. Melvin autonomously learns from solutions for simpler systems, which significantly speeds up the discovery rate of more complex experiments. The ability to automate the design of a quantum experiment can be applied to many quantum systems and allows the physical realization of quantum states previously thought of only on paper. PMID:26991161

  9. The mycotoxin definition reconsidered towards fungal cyclic depsipeptides.

    PubMed

    Taevernier, Lien; Wynendaele, Evelien; De Vreese, Leen; Burvenich, Christian; De Spiegeleer, Bart

    2016-04-01

    Currently, next to the major classes, cyclic depsipeptides beauvericin and enniatins are also positioned as mycotoxins. However, as there are hundreds more fungal cyclic depsipeptides already identified, should these not be considered as mycotoxins as well? The current status of the mycotoxin definition revealed a lack of consistency, leading to confusion about what compounds should be called mycotoxins. Because this is of pivotal importance in risk assessment prioritization, a clear and quantitatively expressed mycotoxin definition is proposed, based on data of widely accepted mycotoxins. Finally, this definition is applied to a set of fungal cyclic depsipeptides, revealing that some of these should indeed be considered as mycotoxins. PMID:26963720

  10. Cyclic plasticity models and application in fatigue analysis

    NASA Technical Reports Server (NTRS)

    Kalev, I.

    1981-01-01

    An analytical procedure for prediction of the cyclic plasticity effects on both the structural fatigue life to crack initiation and the rate of crack growth is presented. The crack initiation criterion is based on the Coffin-Manson formulae extended for multiaxial stress state and for inclusion of the mean stress effect. This criterion is also applied for the accumulated damage ahead of the existing crack tip which is assumed to be related to the crack growth rate. Three cyclic plasticity models, based on the concept of combination of several yield surfaces, are employed for computing the crack growth rate of a crack plane stress panel under several cyclic loading conditions.

  11. Quantum Particles From Quantum Information

    NASA Astrophysics Data System (ADS)

    Görnitz, T.; Schomäcker, U.

    2012-08-01

    Many problems in modern physics demonstrate that for a fundamental entity a more general conception than quantum particles or quantum fields are necessary. These concepts cannot explain the phenomena of dark energy or the mind-body-interaction. Instead of any kind of "small elementary building bricks", the Protyposis, an abstract and absolute quantum information, free of special denotation and open for some purport, gives the solution in the search for a fundamental substance. However, as long as at least relativistic particles are not constructed from the Protyposis, such an idea would remain in the range of natural philosophy. Therefore, the construction of relativistic particles without and with rest mass from quantum information is shown.

  12. Quantum algorithms

    NASA Astrophysics Data System (ADS)

    Abrams, Daniel S.

    This thesis describes several new quantum algorithms. These include a polynomial time algorithm that uses a quantum fast Fourier transform to find eigenvalues and eigenvectors of a Hamiltonian operator, and that can be applied in cases (commonly found in ab initio physics and chemistry problems) for which all known classical algorithms require exponential time. Fast algorithms for simulating many body Fermi systems are also provided in both first and second quantized descriptions. An efficient quantum algorithm for anti-symmetrization is given as well as a detailed discussion of a simulation of the Hubbard model. In addition, quantum algorithms that calculate numerical integrals and various characteristics of stochastic processes are described. Two techniques are given, both of which obtain an exponential speed increase in comparison to the fastest known classical deterministic algorithms and a quadratic speed increase in comparison to classical Monte Carlo (probabilistic) methods. I derive a simpler and slightly faster version of Grover's mean algorithm, show how to apply quantum counting to the problem, develop some variations of these algorithms, and show how both (apparently distinct) approaches can be understood from the same unified framework. Finally, the relationship between physics and computation is explored in some more depth, and it is shown that computational complexity theory depends very sensitively on physical laws. In particular, it is shown that nonlinear quantum mechanics allows for the polynomial time solution of NP-complete and #P oracle problems. Using the Weinberg model as a simple example, the explicit construction of the necessary gates is derived from the underlying physics. Nonlinear quantum algorithms are also presented using Polchinski type nonlinearities which do not allow for superluminal communication. (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  13. Apparent Endless Extraction of Energy from the Vacuum by Cyclic Manipulation of Casimir Cavity Dimensions

    NASA Technical Reports Server (NTRS)

    Forward, Robert L.

    1999-01-01

    In 1983, Ambjorn and Wolfram produced plots of the energy density of the quantum mechanical electromagnetic fluctuations in a volume of vacuum bounded by perfectly conducting walls in the shape of a rectangular cavity of dimensions a(1), a(2), and a(3), as a function of the ratios a(2)/a(1) and a(3)/a(1). Portions of these plots are double-valued, in that they allow rectangular cavities with the same, value of a(2)/a(1), but different values of a(3)/a(1), to have the saint total energy. Using these double-valued regions of the plots, I show that it is possible to define a "Casimir Vacuum Energy Extraction Cycle" which apparently would allow for the endless extraction of energy from the vacuum in the Casimir cavity by cyclic manipulation of the Casimir cavity dimensions.

  14. Introduction to Quantum Simulation

    NASA Technical Reports Server (NTRS)

    Williams, Colin P.

    2005-01-01

    This viewgraph presentation addresses the problem of efficiently simulating the evolution of a quantum system. The contents include: 1) Quantum Simulation; 2) Extracting Answers from Quantum Simulations; 3) Quantum Fourier Transform; 4) Eigenvalue Estimation; 5) Fermionic Simulations.

  15. Quantum Physics for Beginners.

    ERIC Educational Resources Information Center

    Strand, J.

    1981-01-01

    Suggests a new approach for teaching secondary school quantum physics. Reviews traditional approaches and presents some characteristics of the three-part "Quantum Physics for Beginners" project, including: quantum physics, quantum mechanics, and a short historical survey. (SK)

  16. Quantum Statistical Mechanics

    NASA Astrophysics Data System (ADS)

    Schieve, William C.; Horwitz, Lawrence P.

    2009-04-01

    1. Foundations of quantum statistical mechanics; 2. Elementary examples; 3. Quantum statistical master equation; 4. Quantum kinetic equations; 5. Quantum irreversibility; 6. Entropy and dissipation: the microscopic theory; 7. Global equilibrium: thermostatics and the microcanonical ensemble; 8. Bose-Einstein ideal gas condensation; 9. Scaling, renormalization and the Ising model; 10. Relativistic covariant statistical mechanics of many particles; 11. Quantum optics and damping; 12. Entanglements; 13. Quantum measurement and irreversibility; 14. Quantum Langevin equation: quantum Brownian motion; 15. Linear response: fluctuation and dissipation theorems; 16. Time dependent quantum Green's functions; 17. Decay scattering; 18. Quantum statistical mechanics, extended; 19. Quantum transport with tunneling and reservoir ballistic transport; 20. Black hole thermodynamics; Appendix; Index.

  17. Cyclical Regolith Processes on Hydrous Asteroids

    NASA Astrophysics Data System (ADS)

    Zolensky, M. E.

    1995-09-01

    could have occurred during impacts or "volcanic" venting of gas and heat from the interior (this assumes internal heating). Thus, there should have been multiple wet-dry cycles involved in the genesis of these materials. It is well-known to soil scientists that conditions of radically alternating humidity can have important morphologic and petrologic consequences. Grains and lithic clasts can become rotated, crushed and drawn out into linear features (shearing). Porosity (including contraction and shearing cracks) and other bulk physical properties will vary in dramatic manner. These effects would be most pronounced for the CI and CR chondrites, as well as the Kaidun CM1 lithology, where the swelling clay saponite is found in abundance. Easily altered materials will be dissolved while more resistant materials will be pulverized and mixed into matrix [5]. Another important process to be considered is periodic growth and melting of ice crystals in the regolith [6]. The positive molal volume change during crystallization of water will induce oriented microfabrics to develop in the regolith, normal to the direction of ice crystal growth. Thus, platy grains (such as phyllosilicates) will develop a pronounced compaction and preferred alignment. Since the orientation of the growing ice mass will vary for each succeeding generation of growth, the eventual result will be to impart a particular, invasive, regolith fabric consisting of anastomosing strings of phyllosilicates with roughly aligned basal directions for each string. Such textures are common in the wettest chondrites: CIs and CMs. Growth and collapse of these asteroidal icicles will also impart cyclical changes in bulk regolith porosity, induce rotation and movement of crystals and lithic fragments through frost heaving, and consequent shearing. This process could also account, to some degree, for the flattened chondrules. We therefore suggest that cyclical, indigenous environmental processes, rather than impact

  18. A New Interstellar Cyclic Molecule, Ethylene Oxide

    NASA Astrophysics Data System (ADS)

    Dickens, J. E.; Irvine, W. M.; Ohishi, M.; Ikeda, M.; Ishikawa, S.; Nummelin, A.; Hjalmarson, A.

    1997-12-01

    Ethylene oxide (c-C2H4O) is only the fourth known ring molecule identified in the interstellar medium, detected in the Galactic Center cloud SgrB2(N) by Dickens et al. (1997). It is the higher energy isomer of both the more familiar interstellar species acetaldehyde (CH3CHO) and the as yet undetected molecule vinyl alcohol (CH2CHOH). Dickens et al. (1997) reported a c-C2H4O molecular column density about an order of magnitude less than that reported for CH3CHO in SgrB2(N). This is a factor of 200 larger than the predictions of the new standard gas phase chemistry model of Lee, Bettens, and Herbst (1996), suggesting that the formation of c-C2H4O may be related to molecular formation on interstellar grains. We present observations of the c-C2H4O to CH3CHO abundance ratio in 5 additional molecular clouds. The data were taken in October 1997 with the Swedish-European Submillimeter Telescope in Chile. The confirmation of ethylene oxide in molecular clouds provides an appealing scenario for the first link in the chain of reactions leading to the origin of life, since it has been suggested as a possible pathway to the formation of the related cyclic molecule oxiranecarbonitrile (c-C3H3NO; cf., Dickens et al. 1996), a precursor to the synthesis of sugar phosphates which comprise the backbone of our molecular genetic structure. References: Dickens, J.E., Irvine, W.M., Ohishi, M., Ikeda, M., Ishikawa, S., Nummelin, A., and Hjalmarson, A. 1997, Astrophys. J., 489 (in press). Dickens, J.E. et al. 1996, Orig. Life Evol. Biosphere, 26, 97. Lee, H.-H., Bettens, R.P.A., and Herbst, E. 1996, Astron. Astrophys. Supp., 119, 111.

  19. Cyclic Peptidomimetics and Pseudopeptides from Multicomponent Reactions

    NASA Astrophysics Data System (ADS)

    Wessjohann, Ludger A.; Rhoden, Cristiano R. B.; Rivera, Daniel G.; Vercillo, Otilie Eichler

    Multicomponent reactions (MCRs) that provide in the final product amides are suitable to produce peptides and peptide-like moieties. The Passerini and Staudinger reactions provide one amide bond, and the Ugi-four-component reaction generates two amides from three or even four (or more) components, respectively. The Ugi-reaction thus is most important to produce peptides and peptoids while the Passerini reaction is useful to generate depsipeptoid moieties. In order to produce cyclic peptides and pseudopeptides, the linear peptidic MCR products have to be cyclized, usually with the help of bifunctional or activatable building blocks. Orthogonal but cyclizable secondary functionalities that need no protection in isonitrile MCRs commonly include alkenes (for ring closing metathesis), azide/alkyne (for Huisgen click reactions) or dienes and enoates (Diels-Alder) etc. If MCR-reactive groups are to be used also for the cyclisation, monoprotected bifunctional building blocks are used and deprotected after the MCR, e.g. for Ugi reactions as Ugi-Deprotection-Cyclisation (UDC). Alternatively one of the former building blocks or functional groups generated by the MCR can be activated. Most commonly these are activated amides (from so-called convertible isonitriles) which can be used e.g. for Ugi-Activation-Cyclisation (UAC) protocols, or most recently for a simultaneous use of both strategies Ugi-Deprotection/Activation-Cyclisation (UDAC). These methods mostly lead to small, medicinally relevant peptide turn mimics. In an opposing strategy, the MCR is rather used as ring-closing reaction, thereby introducing a (di-)peptide moiety. Most recently these processes have been combined to use MCRs for both, linear precursor synthesis and cyclisation. These multiple MCR approaches allow the most efficient and versatile one pot synthesis of macrocyclic pseudopeptides known to date.

  20. Cyclic di-AMP mediates biofilm formation.

    PubMed

    Peng, Xian; Zhang, Yang; Bai, Guangchun; Zhou, Xuedong; Wu, Hui

    2016-03-01

    Cyclic di-AMP (c-di-AMP) is an emerging second messenger in bacteria. It has been shown to play important roles in bacterial fitness and virulence. However, transduction of c-di-AMP signaling in bacteria and the role of c-di-AMP in biofilm formation are not well understood. The level of c-di-AMP is modulated by activity of di-adenylyl cyclase that produces c-di-AMP and phosphodiesterase (PDE) that degrades c-di-AMP. In this study, we determined that increased c-di-AMP levels by deletion of the pdeA gene coding for a PDE promoted biofilm formation in Streptococcus mutans. Deletion of pdeA upregulated expression of gtfB, the gene coding for a major glucan producing enzyme. Inactivation of gtfB blocked the increased biofilm by the pdeA mutant. Two c-di-AMP binding proteins including CabPA (SMU_1562) and CabPB (SMU_1708) were identified. Interestingly, only CabPA deficiency inhibited both the increased biofilm formation and the upregulated expression of GtfB observed in the pdeA mutant. In addition, CabPA but not CabPB interacted with VicR, a known transcriptional factor that regulates expression of gtfB, suggesting that a signaling link between CabPA and GtfB through VicR. Increased biofilm by the pdeA deficiency also enhanced bacterial colonization of Drosophila in vivo. Taken together, our studies reveal a new role of c-di-AMP in mediating biofilm formation through a CabPA/VicR/GtfB signaling network in S. mutans. PMID:26564551

  1. Steam turbine control valve for cyclic duty

    SciTech Connect

    Dawawala, S.K.; La Coste, B.L.

    1987-07-14

    This patent describes a turbine control valve comprising: a body having a cavity with an elongated generally round first opening on one side. The first opening has a circumferential sealing surface adjacent. A generally round second opening with a valve seat disposes on a side opposite the first opening, and a third opening for admitting steam to the cavity; a valve plug which mates with the valve seat to close off the second opening; a bonnet having a generally cylindrical portion with an integral flange on one end of the cylindrical portion, the flange has a circumferential seal surface which mates with the circumferential sealing surface adjacent the first opening; the bonnet has a centrally disposed bore extending with two counter bores inwardly from the end without the flange; the first counter bore is long and terminates with a large fillet radius; the second counter bore is sufficiently deep to receive the plug and also terminates with a fillet radius. The cylindrical portion has a first raised land on the outer surface adjacent the flange and a second raised land on the outer surface and spaced from the first land and the first raised land is larger in diameter than the second raised land. A plug guide is slidably disposed in the hardened sleeve and on the valve stem and affixed to the valve plug so that the sliding motion between the valve stem and the plug guide is small; the valve plug has a centrally disposed port extending which cooperates with the valve stem to provide means for reducing the force required to remove the plug from the seat to form a control valve operable for cyclic duty where large temperature changes occur at the plug.

  2. Highly Efficient Protein Misfolding Cyclic Amplification

    PubMed Central

    Ostapchenko, Valeriy G.; Savtchenk, Regina; Alexeeva, Irina; Rohwer, Robert G.; Baskakov, Ilia V.

    2011-01-01

    Protein misfolding cyclic amplification (PMCA) provides faithful replication of mammalian prions in vitro and has numerous applications in prion research. However, the low efficiency of conversion of PrPC into PrPSc in PMCA limits the applicability of PMCA for many uses including structural studies of infectious prions. It also implies that only a small sub-fraction of PrPC may be available for conversion. Here we show that the yield, rate, and robustness of prion conversion and the sensitivity of prion detection are significantly improved by a simple modification of the PMCA format. Conducting PMCA reactions in the presence of Teflon beads (PMCAb) increased the conversion of PrPC into PrPSc from ∼10% to up to 100%. In PMCAb, a single 24-hour round consistently amplified PrPSc by 600-700-fold. Furthermore, the sensitivity of prion detection in one round (24 hours) increased by 2-3 orders of magnitude. Using serial PMCAb, a 1012-fold dilution of scrapie brain material could be amplified to the level detectible by Western blotting in 3 rounds (72 hours). The improvements in amplification efficiency were observed for the commonly used hamster 263K strain and for the synthetic strain SSLOW that otherwise amplifies poorly in PMCA. The increase in the amplification efficiency did not come at the expense of prion replication specificity. The current study demonstrates that poor conversion efficiencies observed previously have not been due to the scarcity of a sub-fraction of PrPC susceptible to conversion nor due to limited concentrations of essential cellular cofactors required for conversion. The new PMCAb format offers immediate practical benefits and opens new avenues for developing fast ultrasensitive assays and for producing abundant quantities of PrPSc in vitro. PMID:21347353

  3. Safety Discrete Event Models for Holonic Cyclic Manufacturing Systems

    NASA Astrophysics Data System (ADS)

    Ciufudean, Calin; Filote, Constantin

    In this paper the expression “holonic cyclic manufacturing systems” refers to complex assembly/disassembly systems or fork/join systems, kanban systems, and in general, to any discrete event system that transforms raw material and/or components into products. Such a system is said to be cyclic if it provides the same sequence of products indefinitely. This paper considers the scheduling of holonic cyclic manufacturing systems and describes a new approach using Petri nets formalism. We propose an approach to frame the optimum schedule of holonic cyclic manufacturing systems in order to maximize the throughput while minimize the work in process. We also propose an algorithm to verify the optimum schedule.

  4. Cyclic Segregation State in Vertically Vibrated Binary Granular Mixtures

    NASA Astrophysics Data System (ADS)

    Shi, Qingfan; Pan, Beicheng; Lu, Changhong; Sun, Gang

    2014-01-01

    In this paper, the vertically vibrated binary granular mixtures at atmospheric pressure are studied experimentally. We find a nonstationary segregation state, of which the structure changes with time cyclically. The period of the cyclic segregation is measured and its variation with the vibration conditions is shown. The transition between the segregation states is also discussed, and a phase diagram on the plot of frequency against acceleration amplitude is given. In order to observe the effect of air flow in the segregation process, an alternative container with ventilated bottom is designed. Our experiments show that both regions of the Brazil nut segregation state and the cyclic segregation state shrink obviously by use of the latter container and disappear completely if the whole system is placed in vacuum. These results testify that the air pressure plays a positive role in both the Brazil nut effect and cyclic segregation.

  5. The Cyclical Relationship Approach in Teaching Basic Accounting Principles.

    ERIC Educational Resources Information Center

    Golen, Steven

    1981-01-01

    Shows how teachers can provide a more meaningful presentation of various accounting principles by illustrating them through a cyclical relationship approach. Thus, the students see the entire accounting relationship as a result of doing business. (CT)

  6. Rapid purification of iodinated ligands for cyclic nucleotide radioimmunoassays

    SciTech Connect

    Wilson, S.P.

    1988-01-01

    The tyrosine methyl esters of succinyl cyclic AMP and succinyl cyclic GMP were iodinated by the chloramine T method and individually applied to C18 cartridges. A solution of 1-propanol/0.1 M sodium acetate pH 4.75 (17.5:82.5) was then pumped onto each cartridge and the eluate collected. A large peak of radioactivity, containing primarily the monoiodo and diiodo derivatives, was eluted. Radioactivity in peak fractions was greater than or equal to 95% the monoiodo derivative and represented 20 to 25% of the starting radioactivity. Contamination by the native cyclic nucleotide analogs was less than 5%. These peak fractions containing primarily monoiodinated products worked well in cyclic nucleotide radioimmunoassays. This fractionation required less than 30 min.

  7. [On the subject of the cyclic vomiting syndrome].

    PubMed

    Faucher, S; Le Heuzey, M-F; Rouyer, V; Mouren-Simeoni, M-Ch

    2003-04-01

    The cyclic vomiting syndrome is defined by episodes of vomiting lasting from hours to days with free intervals between episodes. Various symptoms can be associated with vomiting: nausea, abdominal pain, photophobia, fever, pallor, dehydratation, excess salivation, social withdrawal. Some factors often precipitate the crisis: infection, psychological stresses, menstruation. Excluding a medical condition, especially a gastro-intestinal or a neurological disease is compulsory for the diagnostic of cyclic vomiting syndrome. The cyclic vomiting syndrome shares many common features with migraine including treatment. Due to negative paraclinical testing, a psychiatric disease is often suspected in these children. Pathophysiology of cyclic vomiting syndrome is unknown. As for migraine, mitochondrial and ionic channels abnormalities are thought to play a role. Overactivation of hypothalamic-pituitary-adrenal axis and autonomic dysfunction seem to be involved too. Three clinical vignets will illustrate these aspects. PMID:12818770

  8. Inducing coproporphyria in rat hepatocyte cultures using cyclic AMP and cyclic AMP-releasing agents.

    PubMed

    De Matteis, Francesco; Harvey, Carolyn

    2005-07-01

    Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was blocked, even though no inhibition of the relevant enzyme, coproporphyrinogen oxidase, could be demonstrated. Preferential accumulation of coproporphyrin could also be produced in cultures of rat hepatocytes by agents that raise the cellular levels of cyclic AMP, such as glucagon. The effect of supplementing the culture medium with triiodothyronine (T3) on the response of rat hepatocytes to c-AMP was also investigated. T3, which is known to stimulate mitochondrial respiration, uncoupling O2 consumption from ATP synthesis, produced a c-AMP-like effect when given on its own and potentiated the effect of c-AMP, with an apparent increase in the severity of the metabolic block. It is suggested that an oxidative mechanism may be activated in c-AMP and T3-induced coproporphyria, preferentially involving the mitochondrial compartment, leading to oxidation of porphyrinogen intermediates of haem biosynthesis, especially coproporphyrinogen. Coproporphyin, the fully oxidized aromatic derivative produced, cannot be metabolized and will therefore accumulate. PMID:15902420

  9. Unified constitutive modeling for proportional and nonproportional cyclic plasticity responses

    NASA Astrophysics Data System (ADS)

    Krishna, Shree

    Several features of cyclic plasticity, e.g. cyclic hardening/softening, ratcheting, relaxation, and their dependence on strain range, nonproportionality of loading, time, and temperature determine the stress-strain responses of materials under cyclic loading. Numerous efforts have been made in the past decades to characterize and model these responses. Many of these responses can be simulated reasonably by the existing constitutive models, but the same models would fail in simulating the structural responses, local stress-strain or global deformation. One of the reasons for this deficiency is that the constitutive models are not robust enough to simulate the cyclic plasticity responses when they interact with each other. This deficiency can be understood better or resolved by developing and validating constitutive models against a broad set of experimental responses and two or more of the responses interacting with each other. This dissertation develops a unified constitutive model by studying the cyclic plasticity features in an integrated manner and validating the model by simulating a broad set of proportional and nonproportional cyclic plasticity responses. The study demonstrates the drawbacks of the existing nonlinear kinematic hardening model originally developed by Chaboche and then develop and incorporate novel ideas into the model for improving its cyclic response simulations. The Chaboche model is modified by incorporating strain-range dependent cyclic hardening/softening through the kinematic hardening rule parameters, in addition to the conventional method of using only the isotropic hardening parameters. The nonproportional loading memory parameters of Tanaka and of Benallal and Marquis are incorporated to study the influence of nonproportionality. The model is assessed by simulating hysteresis loop shape, cyclic hardening-softening, cross-effect, cyclic relaxation, subsequent cyclic softening, and finally a series of ratcheting responses under

  10. Quantum walk computation

    SciTech Connect

    Kendon, Viv

    2014-12-04

    Quantum versions of random walks have diverse applications that are motivating experimental implementations as well as theoretical studies. Recent results showing quantum walks are “universal for quantum computation” relate to algorithms, to be run on quantum computers. We consider whether an experimental implementation of a quantum walk could provide useful computation before we have a universal quantum computer.

  11. Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

    PubMed Central

    Koopmanschap, Gijs; Ruijter, Eelco

    2014-01-01

    Summary In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certain receptor. Moreover, these cyclic mimics force the molecule into a well-defined secondary structure. Constraint structural and conformational features are often found in biological active peptides. For the synthesis of cyclic constrained peptidomimetics usually a sequence of multiple reactions has been applied, which makes it difficult to easily introduce structural diversity necessary for fine tuning the biological activity. A promising approach to tackle this problem is the use of multicomponent reactions (MCRs), because they can introduce both structural diversity and molecular complexity in only one step. Among the MCRs, the isocyanide-based multicomponent reactions (IMCRs) are most relevant for the synthesis of peptidomimetics because they provide peptide-like products. However, these IMCRs usually give linear products and in order to obtain cyclic constrained peptidomimetics, the acyclic products have to be cyclized via additional cyclization strategies. This is possible via incorporation of bifunctional substrates into the initial IMCR. Examples of such bifunctional groups are N-protected amino acids, convertible isocyanides or MCR-components that bear an additional alkene, alkyne or azide moiety and can be cyclized via either a deprotection–cyclization strategy, a ring-closing metathesis, a 1,3-dipolar cycloaddition or even via a sequence of multiple multicomponent reactions. The sequential IMCR-cyclization reactions can afford small cyclic peptide mimics (ranging from four- to seven-membered rings), medium-sized cyclic constructs or peptidic macrocycles

  12. Self-assembly of cyclic rod-coil diblock copolymers.

    PubMed

    He, Linli; Chen, Zenglei; Zhang, Ruifen; Zhang, Linxi; Jiang, Zhouting

    2013-03-01

    The phase behavior of cyclic rod-coil diblock copolymer melts is investigated by the dissipative particle dynamics simulation. In order to understand the effect of chain topological architecture better, we also study the linear rod-coil system. The comparison of the calculated phase diagrams between the two rod-coil copolymers reveals that the order-disorder transition point (χN)ODT for cyclic rod-coil diblock copolymers is always higher than that of equivalent linear rod-coil diblocks. In addition, the phase diagram for cyclic system is more "symmetrical," due to the topological constraint. Moreover, there are significant differences in the self-assembled overall morphologies and the local molecular arrangements. For example, frod = 0.5, both lamellar structures are formed while rod packing is different greatly in cyclic and linear cases. The lamellae with rods arranged coplanarly into bilayers occurs in cyclic rod-coil diblocks, while the lamellar structure with rods arranged end by end into interdigitated bilayers appears in linear counterpart. In both the lamellar phases, the domain size ratio of cyclic to linear diblocks is ranged from 0.63 to 0.70. This is attributed to that the cyclic architecture with the additional junction increases the contacts between incompatible blocks and prevents the coil chains from expanding as much as the linear cases. As frod = 0.7, the hexagonally packed cylinder is observed for cyclic rod-coil diblocks, while liquid-crystalline smectic A lamellar phase is formed in linear system. As a result, the cyclization of a linear rod-coil block copolymer can induce remarkable differences in the self-assembly behavior and also diversify its physical properties and applications greatly. PMID:23485326

  13. Phantom energy accretion onto black holes in a cyclic universe

    SciTech Connect

    Sun Chengyi

    2008-09-15

    Black holes pose a serious problem in cyclic or oscillating cosmology. It is speculated that, in the cyclic universe with phantom turnarounds, black holes will be torn apart by phantom energy prior to turnaround before they can create any problems. In this paper, using the mechanism of phantom accretion onto black holes, we find that black holes do not disappear before phantom turnaround. But the remanent black holes will not cause any problems due to Hawking evaporation.

  14. New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge

    PubMed Central

    Hoye, Thomas R.; Alarif, Walied M.; Basaif, Salim S.; Abo-Elkarm, Mohamed; Hamann, Mark T.; Wahba, Amir E.; Ayyad, Seif-Eldin N.

    2016-01-01

    Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines. PMID:26835518

  15. Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors†

    PubMed Central

    Rudick, Jonathan G.; Laakso, Meg M.; Schloss, Ashley C.; DeGrado, William F.

    2013-01-01

    Template-constrained cyclic sulfopeptides that inhibit HIV-1 entry were rationally designed based on a loop from monoclonal antibody (mAb) 412d. A focused set of sulfopeptides was synthesized using Fmoc-Tyr(SO3DCV)-OH (DCV = 2,2-dichlorovinyl). Three cyclic sulfopeptides that inhibit entry of HIV-1 and complement the activity of known CCR5 antagonists were identified. PMID:24065278

  16. A computer program for cyclic plasticity and structural fatigue analysis

    NASA Technical Reports Server (NTRS)

    Kalev, I.

    1980-01-01

    A computerized tool for the analysis of time independent cyclic plasticity structural response, life to crack initiation prediction, and crack growth rate prediction for metallic materials is described. Three analytical items are combined: the finite element method with its associated numerical techniques for idealization of the structural component, cyclic plasticity models for idealization of the material behavior, and damage accumulation criteria for the fatigue failure.

  17. The Nature's Clever Trick for Making Cyclic Dinucleotide.

    PubMed

    Fang, Pengfei; Guo, Min

    2015-05-01

    Ever since their initial discovery few years ago, cyclic dinucleotides (cDNs), their biosynthesis, and their biological function have been in focus of intense research efforts. In this issue, Kato et al. (2015) present strong evidence that the key enzyme in cDN biosynthesis, DncV, is poised on a tipping point such that, given a nudge, the enzyme, can link the nucleotides into a distinct cyclic loop, leading to a specific innate immune response. PMID:25955098

  18. Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics

    PubMed Central

    Berhanu, Workalemahu M; Ibrahim, Mohamed A; Pillai, Girinath G; Oliferenko, Alexander A; Khelashvili, Levan; Jabeen, Farukh; Mirza, Bushra; Ansari, Farzana Latif; ul-Haq, Ihsan; El-Feky, Said A

    2012-01-01

    Summary The chemical similarity of antibacterial cyclic peptides and peptidomimetics was studied in order to identify new promising cyclic scaffolds. A large descriptor space coupled with cluster analysis was employed to digitize known antibacterial structures and to gauge the potential of new peptidomimetic macrocycles, which were conveniently synthesized by acylbenzotriazole methodology. Some of the synthesized compounds were tested against an array of microorganisms and showed antibacterial activity against Bordetella bronchistepica, Micrococcus luteus, and Salmonella typhimurium. PMID:23019443

  19. Synthesis and Structure of Cyclic Trisaccharide with Expanded Glycosidic Linkages.

    PubMed

    Maiti, Krishnagopal; Jayaraman, Narayanaswamy

    2016-06-01

    A new cyclic trisaccharide is synthesized by cycloglycosylation of a linear trisaccharide, modified with hydroxymethyl moiety at C4 of glucopyranose moiety. The cyclic trisaccharide possesses a rarely observed perfect trigonal symmetry in the P3 space group, in a narrow cone shape, and a brick-wall type arrangement of molecules in the solid state, and exhibits a significantly enhanced binding affinity to 1-aminoadamantane in aqueous solution. PMID:27182797

  20. Quantum Cryptography

    NASA Astrophysics Data System (ADS)

    Bruß, D.; Meyer, T.

    The Greek words "kryptos" ≡ "hidden" and "logos" ≡ "word" are the etymological sources for "cryptology," the science of secure communication. Within cryptology, one distinguishes cryptography (or "code-making") and cryptanalysis (or "code-breaking"). The aim of cryptography is to ensure secret or "secure" communication between a sender, traditionally called Alice, and a receiver, called Bob. The encryption and decryption of a so-called plain text into a cipher text and back is achieved using a certain key (not necessarily the same for Alice and Bob), as illustrated in Fig. 1. Here, "secure" means that an eavesdropper, called Eve, has no information on the message. In this chapter we will show that in classical cryptography (using classical signals), security relies on the assumed difficulty to solve certain mathematical tasks, whereas in quantum cryptography (using quantum signals), security arises from the laws of quantum physics.

  1. Quantum spirals

    NASA Astrophysics Data System (ADS)

    Yoshida, Z.; Mahajan, S. M.

    2016-02-01

    Quantum systems often exhibit fundamental incapability to entertain vortex. The Meissner effect, a complete expulsion of the magnetic field (the electromagnetic vorticity), for instance, is taken to be the defining attribute of the superconducting state. Superfluidity is another, close-parallel example; fluid vorticity can reside only on topological defects with a limited (quantized) amount. Recent developments in the Bose-Einstein condensates produced by particle traps further emphasize this characteristic. We show that the challenge of imparting vorticity to a quantum fluid can be met through a nonlinear mechanism operating in a hot fluid corresponding to a thermally modified Pauli-Schrödinger spinor field. The thermal baroclinic effect is represented by a nonlinear, non-Hermitian Hamiltonian, which, in conjunction with spin vorticity, leads to new interesting quantum states; a spiral solution is explicitly worked out in a simple field-free model.

  2. Are Submarine Cyclic Steps Present on the Surface of Mars?

    NASA Astrophysics Data System (ADS)

    Kostic, Svetlana; Covault, Jacob A.; Smith, Isaac

    2015-04-01

    Cyclic steps emplaced by turbidity currents are common features on the ocean floor of Earth. Recent observations and modeling studies have indicated that cyclic steps exist on Mars as well. The spiral troughs of Mars North Polar Layered Deposits have been interpreted as cyclic steps. Their formation and evolution can be tied to atmospheric processes, including Coriolis steered katabatic winds and asymmetric ice accumulation that is caused by katabatic jumps. The objective of this research is to evaluate whether cyclic steps emplaced by turbidity currents are present on the surface of Mars. The presence of deep-sea cyclic steps on the surface of Mars might favor the existence of a Martian ocean, analogous to Earth. We have started our search by looking at surface data collected by Mars Orbiter Laser Altimeter (MOLA) topography with the Context Imager (CTX), High Resolution Imaging Science Experiment (HiRISE), and Mars Orbiter Camera (MOC) images and literature on Martian bedforms. Preliminary results of our search highlight potential remnants of cyclic steps on several fluvial delta deposits spreading along a proposed shoreline of the shallow primordial ocean.

  3. Quantum diffusion

    SciTech Connect

    Habib, S.

    1994-10-01

    We consider a simple quantum system subjected to a classical random force. Under certain conditions it is shown that the noise-averaged Wigner function of the system follows an integro-differential stochastic Liouville equation. In the simple case of polynomial noise-couplings this equation reduces to a generalized Fokker-Planck form. With nonlinear noise injection new ``quantum diffusion`` terms rise that have no counterpart in the classical case. Two special examples that are not of a Fokker-Planck form are discussed: the first with a localized noise source and the other with a spatially modulated noise source.

  4. Quantum Uniqueness

    NASA Astrophysics Data System (ADS)

    Sych, Denis; Leuchs, Gerd

    2015-12-01

    Classical physics allows for the existence of pairs of absolutely identical systems. Pairwise application of identical measurements to each of those systems always leads to exactly alike results irrespectively of the choice of measurements. Here we ask a question how the picture looks like in the quantum domain. Surprisingly, we get a counterintuitive outcome. Pairwise application of identical (but a priori unknown) measurements cannot always lead to exactly alike results. We interpret this as quantum uniqueness—a feature that has no classical analog.

  5. Quantum Foam

    SciTech Connect

    Lincoln, Don

    2014-10-24

    The laws of quantum mechanics and relativity are quite perplexing however it is when the two theories are merged that things get really confusing. This combined theory predicts that empty space isn’t empty at all – it’s a seething and bubbling cauldron of matter and antimatter particles springing into existence before disappearing back into nothingness. Scientists call this complicated state of affairs “quantum foam.” In this video, Fermilab’s Dr. Don Lincoln discusses this mind-bending idea and sketches some of the experiments that have convinced scientists that this crazy prediction is actually true.

  6. Quantum Finance

    NASA Astrophysics Data System (ADS)

    Baaquie, Belal E.

    2007-09-01

    Foreword; Preface; Acknowledgements; 1. Synopsis; Part I. Fundamental Concepts of Finance: 2. Introduction to finance; 3. Derivative securities; Part II. Systems with Finite Number of Degrees of Freedom: 4. Hamiltonians and stock options; 5. Path integrals and stock options; 6. Stochastic interest rates' Hamiltonians and path integrals; Part III. Quantum Field Theory of Interest Rates Models: 7. Quantum field theory of forward interest rates; 8. Empirical forward interest rates and field theory models; 9. Field theory of Treasury Bonds' derivatives and hedging; 10. Field theory Hamiltonian of forward interest rates; 11. Conclusions; Appendix A: mathematical background; Brief glossary of financial terms; Brief glossary of physics terms; List of main symbols; References; Index.

  7. Quantum Computation

    NASA Astrophysics Data System (ADS)

    Ekert, Artur

    1994-08-01

    As computers become faster they must become smaller because of the finiteness of the speed of light. The history of computer technology has involved a sequence of changes from one type of physical realisation to another - from gears to relays to valves to transistors to integrated circuits and so on. Quantum mechanics is already important in the design of microelectronic components. Soon it will be necessary to harness quantum mechanics rather than simply take it into account, and at that point it will be possible to give data processing devices new functionality.

  8. Cyclic Versus Linear Isomers Produced by Reaction of the Methylidyne Radical (CH) with Small Unsaturated Hydrocarbons

    SciTech Connect

    Goulay, Fabien; Trevitt, Adam J.; Meloni, Giovanni; Selby, Talitha M.; Osborn, David L.; Taatjes, Craig A.; Vereecken, Luc; Leone, Stephen R.

    2008-12-05

    The reactions of the methylidyne radical (CH) with ethylene, acetylene, allene, and methylacetylene are studied at room temperature using tunable vacuum ultraviolet (VUV) photoionization and time-resolved mass spectrometry. The CH radicals are prepared by 248 nm multiphoton photolysis of CHBr3 at 298 K and react with the selected hydrocarbon in a helium gas flow. Analysis of photoionization efficiency versus VUV photon wavelength permits isomer-specific detection of the reaction products and allows estimation of the reaction product branching ratios. The reactions proceed by either CH insertion or addition followed by H atom elimination from the intermediate adduct. In the CH + C2H4 reaction the C3H5 intermediate decays by H atom loss to yield 70(+-8)percent allene, 30(+-8)percent methylacetylene and less than 10percent cyclopropene, in agreement with previous RRKM results. In the CH + acetylene reaction, detection of mainly the cyclic C3H2 isomer is contrary to a previous RRKM calculation that predicted linear triplet propargylene to be 90percent of the total H-atom co-products. High-level CBS-APNO quantum calculations and RRKM calculation for the CH + C2H2 reaction presented in this manuscript predict a higher contribution of the cyclic C3H2 (27.0percent) versus triplet propargylene (63.5percent) than these earlier predictions. Extensive calculations on the C3H3 and C3H2D system combined with experimental isotope ratios for the CD + C2H2 reaction indicate that H-atom assisted isomerization in the present experiments is responsible for the discrepancy between the RRKM calculations and the experimental results. Cyclic isomers are also found to represent 30(+-6)percent of the detected products in the case of CH + methylacetylene, together with 33(+-6)percent 1,2,3-butatriene and 37(+-6)percent vinylacetylene. The CH + allene reaction gives 23(+-5)percent 1,2,3-butatriene and 77(+-5)percent vinylacetylene, whereas cyclic isomers are produced below the detection limit

  9. 8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist

    PubMed Central

    Kirchberger, Tanja; Moreau, Christelle; Wagner, Gerd K.; Fliegert, Ralf; Siebrands, Cornelia C.; Nebel, Merle; Schmid, Frederike; Harneit, Angelika; Odoardi, Francesca; Flügel, Alexander; Potter, Barry V. L.; Guse, Andreas H.

    2009-01-01

    cADPR (cyclic ADP-ribose) is a universal Ca2+ mobilizing second messenger. In T-cells cADPR is involved in sustained Ca2+ release and also in Ca2+ entry. Potential mechanisms for the latter include either capacitative Ca2+ entry, secondary to store depletion by cADPR, or direct activation of the non-selective cation channel TRPM2 (transient receptor potential cation channel, subfamily melastatin, member 2). Here we characterize the molecular target of the newly-described membrane-permeant cADPR agonist 8-Br-N1-cIDPR (8-bromo-cyclic IDP-ribose). 8-Br-N1-cIDPR evoked Ca2+ signalling in the human T-lymphoma cell line Jurkat and in primary rat T-lymphocytes. Ca2+ signalling induced by 8-Br-N1-cIDPR consisted of Ca2+ release and Ca2+ entry. Whereas Ca2+ release was sensitive to both the RyR (ryanodine receptor) blocker RuRed (Ruthenium Red) and the cADPR antagonist 8-Br-cADPR (8-bromo-cyclic ADP-ribose), Ca2+ entry was inhibited by the Ca2+ entry blockers Gd3+ (gadolinium ion) and SKF-96365, as well as by 8-Br-cADPR. To unravel a potential role for TRPM2 in sustained Ca2+ entry evoked by 8-Br-N1-cIDPR, TRPM2 was overexpressed in HEK (human embryonic kidney)-293 cells. However, though activation by H2O2 was enhanced dramatically in those cells, Ca2+ signalling induced by 8-Br-N1-cIDPR was almost unaffected. Similarly, direct analysis of TRPM2 currents did not reveal activation or co-activation of TRPM2 by 8-Br-N1-cIDPR. In summary, the sensitivity to the Ca2+ entry blockers Gd3+ and SKF-96365 is in favour of the concept of capacitative Ca2+ entry, secondary to store depletion by 8-Br-N1-cIDPR. Taken together, 8-Br-N1-cIDPR appears to be the first cADPR agonist affecting Ca2+ release and secondary Ca2+ entry, but without effect on TRPM2. PMID:19492987

  10. Quantum learning without quantum memory

    PubMed Central

    Sentís, G.; Calsamiglia, J.; Muñoz-Tapia, R.; Bagan, E.

    2012-01-01

    A quantum learning machine for binary classification of qubit states that does not require quantum memory is introduced and shown to perform with the minimum error rate allowed by quantum mechanics for any size of the training set. This result is shown to be robust under (an arbitrary amount of) noise and under (statistical) variations in the composition of the training set, provided it is large enough. This machine can be used an arbitrary number of times without retraining. Its required classical memory grows only logarithmically with the number of training qubits, while its excess risk decreases as the inverse of this number, and twice as fast as the excess risk of an “estimate-and-discriminate” machine, which estimates the states of the training qubits and classifies the data qubit with a discrimination protocol tailored to the obtained estimates. PMID:23050092

  11. 7 CFR 1412.33 - Payment yield for counter-cyclical payments for covered commodities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Payment yield for counter-cyclical payments for... CROP YEARS Establishment of Yields for Direct and Counter-Cyclical Payments § 1412.33 Payment yield for counter-cyclical payments for covered commodities. The counter-cyclical payment yield for...

  12. 7 CFR 1412.33 - Payment yield for counter-cyclical payments for covered commodities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Payment yield for counter-cyclical payments for... CROP YEARS Establishment of Yields for Direct and Counter-Cyclical Payments § 1412.33 Payment yield for counter-cyclical payments for covered commodities. The counter-cyclical payment yield for...

  13. Quantum Interferometry

    NASA Technical Reports Server (NTRS)

    Dowling, Jonathan P.

    2000-01-01

    Recently, several researchers, including yours truly, have been able to demonstrate theoretically that quantum photon entanglement has the potential to also revolutionize the entire field of optical interferometry, by providing many orders of magnitude improvement in interferometer sensitivity. The quantum entangled photon interferometer approach is very general and applies to many types of interferometers. In particular, without nonlocal entanglement, a generic classical interferometer has a statistical-sampling shot-noise limited sensitivity that scales like 1/Sqrt[N], where N is the number of particles (photons, electrons, atoms, neutrons) passing through the interferometer per unit time. However, if carefully prepared quantum correlations are engineered between the particles, then the interferometer sensitivity improves by a factor of Sqrt[N] (square root of N) to scale like 1/N, which is the limit imposed by the Heisenberg Uncertainty Principle. For optical (laser) interferometers operating at milliwatts of optical power, this quantum sensitivity boost corresponds to an eight-order-of-magnitude improvement of signal to noise. Applications are to tests of General Relativity such as ground and orbiting optical interferometers for gravity wave detection, Laser Interferometer Gravity Observatory (LIGO) and the European Laser Interferometer Space Antenna (LISA), respectively.

  14. Quantum abacus

    NASA Astrophysics Data System (ADS)

    Cheon, Taksu; Tsutsui, Izumi; Fülöp, Tamás

    2004-09-01

    We show that the point interactions on a line can be utilized to provide U(2) family of qubit operations for quantum information processing. Qubits are realized as states localized in either side of the point interaction which represents a controllable gate. The qubit manipulation proceeds in a manner analogous to the operation of an abacus.

  15. Quantum wormholes

    SciTech Connect

    Visser, M. )

    1991-01-15

    This paper presents an application of quantum-mechanical principles to a microscopic variant of the traversable wormholes recently introduced by Morris and Thorne. The analysis, based on the surgical grafting of two Reissner-Nordstroem spacetimes, proceeds by using a minisuperspace model to approximate the geometry of these wormholes. The thin shell'' formalism is applied to this minisuperspace model to extract the effective Lagrangian appropriate to this one-degree-of-freedom system. This effective Lagrangian is then quantized and the wave function for the wormhole is explicitly exhibited. A slightly more general class of wormholes---corresponding to the addition of some dust'' to the wormhole throat---is analyzed by recourse to WKB techniques. In all cases discussed in this paper, the expectation value of the wormhole radius is calculated to be of the order of the Planck length. Accordingly, though these quantum wormholes are of considerable theoretical interest they do not appear to be useful as a means for interstellar travel. The results of this paper may also have a bearing on the question of topological fluctuations in quantum gravity. These calculations serve to suggest that topology-changing effects might in fact be {ital suppressed} by quantum-gravity effects.

  16. Quantum warming

    NASA Astrophysics Data System (ADS)

    2009-01-01

    The demonstration in this issue that strong magnetic confinement of electrons can dramatically increase the operating temperature of terahertz quantum cascade lasers is good news for the dream of reaching room temperature. Nature Photonics spoke with Qing Hu about the result and the future prospects.

  17. Quantum dice

    SciTech Connect

    Sassoli de Bianchi, Massimiliano

    2013-09-15

    In a letter to Born, Einstein wrote [42]: “Quantum mechanics is certainly imposing. But an inner voice tells me that it is not yet the real thing. The theory says a lot, but does not really bring us any closer to the secret of the ‘old one.’ I, at any rate, am convinced that He does not throw dice.” In this paper we take seriously Einstein’s famous metaphor, and show that we can gain considerable insight into quantum mechanics by doing something as simple as rolling dice. More precisely, we show how to perform measurements on a single die, to create typical quantum interference effects, and how to connect (entangle) two identical dice, to maximally violate Bell’s inequality. -- Highlights: •Rolling a die is a quantum process admitting a Hilbert space representation. •Rolling experiments with a single die can produce interference effects. •Two connected dice can violate Bell’s inequality. •Correlations need to be created by the measurement, to violate Bell’s inequality.

  18. Quantum Gambling

    NASA Astrophysics Data System (ADS)

    Goldenberg, Lior; Vaidman, Lev; Wiesner, Stephen

    1999-04-01

    We present a two-party protocol for ``quantum gambling,'' a new task closely related to coin tossing. The protocol allows two remote parties to play a gambling game such that in a certain limit it becomes a fair game. No unconditionally secure classical method is known to accomplish this task.

  19. Quantum rendering

    NASA Astrophysics Data System (ADS)

    Lanzagorta, Marco O.; Gomez, Richard B.; Uhlmann, Jeffrey K.

    2003-08-01

    In recent years, computer graphics has emerged as a critical component of the scientific and engineering process, and it is recognized as an important computer science research area. Computer graphics are extensively used for a variety of aerospace and defense training systems and by Hollywood's special effects companies. All these applications require the computer graphics systems to produce high quality renderings of extremely large data sets in short periods of time. Much research has been done in "classical computing" toward the development of efficient methods and techniques to reduce the rendering time required for large datasets. Quantum Computing's unique algorithmic features offer the possibility of speeding up some of the known rendering algorithms currently used in computer graphics. In this paper we discuss possible implementations of quantum rendering algorithms. In particular, we concentrate on the implementation of Grover's quantum search algorithm for Z-buffering, ray-tracing, radiosity, and scene management techniques. We also compare the theoretical performance between the classical and quantum versions of the algorithms.

  20. Optimal evolution models for quantum tomography

    NASA Astrophysics Data System (ADS)

    Czerwiński, Artur

    2016-02-01

    The research presented in this article concerns the stroboscopic approach to quantum tomography, which is an area of science where quantum physics and linear algebra overlap. In this article we introduce the algebraic structure of the parametric-dependent quantum channels for 2-level and 3-level systems such that the generator of evolution corresponding with the Kraus operators has no degenerate eigenvalues. In such cases the index of cyclicity of the generator is equal to 1, which physically means that there exists one observable the measurement of which performed a sufficient number of times at distinct instants provides enough data to reconstruct the initial density matrix and, consequently, the trajectory of the state. The necessary conditions for the parameters and relations between them are introduced. The results presented in this paper seem to have considerable potential applications in experiments due to the fact that one can perform quantum tomography by conducting only one kind of measurement. Therefore, the analyzed evolution models can be considered optimal in the context of quantum tomography. Finally, we introduce some remarks concerning optimal evolution models in the case of n-dimensional Hilbert space.

  1. Cyclical Regolith Processes on Hydrous Asteroids

    NASA Astrophysics Data System (ADS)

    Zolensky, M. E.

    1995-09-01

    could have occurred during impacts or "volcanic" venting of gas and heat from the interior (this assumes internal heating). Thus, there should have been multiple wet-dry cycles involved in the genesis of these materials. It is well-known to soil scientists that conditions of radically alternating humidity can have important morphologic and petrologic consequences. Grains and lithic clasts can become rotated, crushed and drawn out into linear features (shearing). Porosity (including contraction and shearing cracks) and other bulk physical properties will vary in dramatic manner. These effects would be most pronounced for the CI and CR chondrites, as well as the Kaidun CM1 lithology, where the swelling clay saponite is found in abundance. Easily altered materials will be dissolved while more resistant materials will be pulverized and mixed into matrix [5]. Another important process to be considered is periodic growth and melting of ice crystals in the regolith [6]. The positive molal volume change during crystallization of water will induce oriented microfabrics to develop in the regolith, normal to the direction of ice crystal growth. Thus, platy grains (such as phyllosilicates) will develop a pronounced compaction and preferred alignment. Since the orientation of the growing ice mass will vary for each succeeding generation of growth, the eventual result will be to impart a particular, invasive, regolith fabric consisting of anastomosing strings of phyllosilicates with roughly aligned basal directions for each string. Such textures are common in the wettest chondrites: CIs and CMs. Growth and collapse of these asteroidal icicles will also impart cyclical changes in bulk regolith porosity, induce rotation and movement of crystals and lithic fragments through frost heaving, and consequent shearing. This process could also account, to some degree, for the flattened chondrules. We therefore suggest that cyclical, indigenous environmental processes, rather than impact

  2. Quantum ellipsometry

    NASA Astrophysics Data System (ADS)

    Toussaint, Kimani Christopher, Jr.

    Ellipsometry is a technique in which the polarization of light is used to determine the optical properties of a material (sample) and infer information such as the thickness of a thin film. Traditional ellipsometric measurements are limited in their accuracy because of the use of an external reference sample for calibration, and because of the quantum noise inherent in the source that becomes important at low light levels. A new technique called quantum ellipsometry is investigated, and is shown to circumvent these limitations by using a non-classical source of light, namely, twin photons generated by the process of spontaneous parametric downconversion (SPDC), in conjunction with a novel polarization interferometer and coincidence-counting detection scheme. Quantum ellipsometry comes in two forms: correlated-photon and entangled-photon ellipsometry. Both ellipsometric techniques yield estimated of the sample reflectance/transmittance with accuracy greater than conventional ellipsometry. Specifically, when the quantum efficiencies of the detectors used are above a certain threshold the signal-to-noise ratio of the measured ellipsometric parameters is larger for quantum ellipsometry than for conventional ellipsometry. This is because the photon pairs generated by SPDC have a fully correlated joint photon counting distribution. Furthermore, both correlated-photon and entangled-photon ellipsometry have the added advantage that they do not require calibration by an external reference sample, which is another limitation on the accuracy for most conventional ellipsometry. Quantum ellipsometry exploits the property of photon number correlation and polarization entanglement. The entanglement property, inherent in entangled-photon ellipsometry, is shown to allow for the movement of the optical elements that precede the sample to the sample-free optical channel in the setup. A theoretical and experimental investigation of quantum ellipsometry was conducted. Both correlated

  3. Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose.

    PubMed

    Hammerschmidt, Andreas; Chatterji, Bijon; Zeiser, Johannes; Schröder, Anke; Genieser, Hans-Gottfried; Pich, Andreas; Kaever, Volkhard; Schwede, Frank; Wolter, Sabine; Seifert, Roland

    2012-01-01

    The bacterial adenylyl cyclase toxins CyaA from Bordetella pertussis and edema factor from Bacillus anthracis as well as soluble guanylyl cyclase α(1)β(1) synthesize the cyclic pyrimidine nucleotide cCMP. These data raise the question to which effector proteins cCMP binds. Recently, we reported that cCMP activates the regulatory subunits RIα and RIIα of cAMP-dependent protein kinase. In this study, we used two cCMP agarose matrices as novel tools in combination with immunoblotting and mass spectrometry to identify cCMP-binding proteins. In agreement with our functional data, RIα and RIIα were identified as cCMP-binding proteins. These data corroborate the notion that cAMP-dependent protein kinase may serve as a cCMP target. PMID:22808067

  4. The Behaviour of Reinforced Concrete Subjected to Reversed Cyclic Shear

    NASA Astrophysics Data System (ADS)

    Ruggiero, David Michael Volpe

    Reversed cyclic loading, as may occur during seismic events, can cause sudden and brittle shear failures in reinforced concrete structural members. This thesis presents both experimental and analytical investigations into the behaviour of members subjected to reversed cyclic shear loading, and culminates in the development of a new, rational model to describe this behaviour. In the experimental phase of the research, ten reinforced concrete shell elements were tested under reversed cyclic in-plane shear loads. Data collected by means of several acquisition systems allowed extensive analysis of the experiments, and provided insight into the behaviour of the crack interfaces. In comparison with existing models, such as the Modified Compression Field Theory, it was found that the shear strengths of these reversed cyclically loaded specimens were as much as 25% lower than monotonic predictions. The results of the experimental program informed the development of a new analytical model, the General Crack Component Model (GCCM). The central concept of the GCCM is that the reversed cyclic behaviour of a shear panel depends on the behaviour of multiple crack systems, each with its own constitutive properties. A rigorous framework based on the principles of compatibility and equilibrium was formulated in order to allow for the appropriate combination of the stiffnesses of the three components of the model: concrete, steel, and cracks. The GCCM was validated for reversed cyclic and monotonic loading by comparison with the experimental results as well as data from other researchers. It was shown that the model provides good estimates of the behaviour of reinforced concrete subjected to reversed cyclic loads, and that it can be used as part of a larger structural analysis, ultimately helping engineers to design safer structures and more accurately assess the safety of existing construction.

  5. Quantum state and quantum entanglement protection using quantum measurements

    NASA Astrophysics Data System (ADS)

    Wang, Shuchao; Li, Ying; Wang, Xiangbin; Kwek, Leong Chuan; Yu, Zongwen; Zou, Wenjie

    2015-03-01

    The time evolution of some quantum states can be slowed down or even stopped under frequent measurements. This is the usual quantum Zeno effect. Here we report an operator quantum Zeno effect, in which the evolution of some physical observables is slowed down through measurements even though thequantum state changes randomly with time. Based on the operator quantum Zeno effect, we show how we can protect quantum information from decoherence with two-qubit measurements, realizable with noisy two-qubit interactions. Besides, we report the quantum entanglement protection using weak measurement and measurement reversal scheme. Exposed in the nonzero temperature environment, a quantum system can both lose and gain excitations by interacting with the environment. In this work, we show how to optimally protect quantum states and quantum entanglement in such a situation based on measurement reversal from weak measurement. In particular, we present explicit formulas of protection. We find that this scheme can circumvent the entanglement sudden death in certain conditions.

  6. Anti-de Sitter universe dynamics in loop quantum cosmology

    SciTech Connect

    Bentivegna, Eloisa; Pawlowski, Tomasz

    2008-06-15

    A model for a flat isotropic universe with a negative cosmological constant {lambda} and a massless scalar field as sole matter content is studied within the framework of loop quantum cosmology. By application of the methods introduced for the model with {lambda}=0, the physical Hilbert space and the set of Dirac observables are constructed. As in that case, the scalar field plays here the role of an emergent time. The properties of the system are found to be similar to those of the k=1 Friedmann-Robertson-Walker (FRW) model: for small energy densities, the quantum dynamics reproduces the classical one, whereas, due to modifications at near-Planckian densities, the big bang and big crunch singularities are replaced by a quantum bounce connecting deterministically the large semiclassical epochs. Thus in loop quantum cosmology the evolution is qualitatively cyclic.

  7. Anti-de Sitter universe dynamics in loop quantum cosmology

    NASA Astrophysics Data System (ADS)

    Bentivegna, Eloisa; Pawlowski, Tomasz

    2008-06-01

    A model for a flat isotropic universe with a negative cosmological constant Λ and a massless scalar field as sole matter content is studied within the framework of loop quantum cosmology. By application of the methods introduced for the model with Λ=0, the physical Hilbert space and the set of Dirac observables are constructed. As in that case, the scalar field plays here the role of an emergent time. The properties of the system are found to be similar to those of the k=1 Friedmann-Robertson-Walker (FRW) model: for small energy densities, the quantum dynamics reproduces the classical one, whereas, due to modifications at near-Planckian densities, the big bang and big crunch singularities are replaced by a quantum bounce connecting deterministically the large semiclassical epochs. Thus in loop quantum cosmology the evolution is qualitatively cyclic.

  8. PSI-driven cyclic electron flow allows intertidal macro-algae Ulva sp. (Chlorophyta) to survive in desiccated conditions.

    PubMed

    Gao, Shan; Shen, Songdong; Wang, Guangce; Niu, Jianfeng; Lin, Apeng; Pan, Guanghua

    2011-05-01

    Ulva sp. (Chlorophyta) is a representative species of the intertidal macro-algae responsible for the green tides that occurred along the shores of Qingdao in 2008 and had detrimental effects on the preparation for the 2008 Beijing Olympic Games sailing competition. In view of its significance, we have investigated the photosynthetic performance of the photosystems and the changes in photosynthetic electron transport that occur during desiccation and rehydration of Ulva sp. The PSII activity in Ulva sp. declined gradually during the course of desiccation, which was reflected by the decreased maximum quantum yield and effective quantum yield, whereas the PSI activity fluctuated significantly. In contrast, the electron transport rates of PSII approached zero at severe levels of desiccation, but the electron transport of PSI, which still operated, could be suppressed effectively by a specific inhibitor. Furthermore, the electron transport of PSI during rehydration of desiccated thalli was recovered faster than that of PSII. All these results implied that the linear electron flow was abolished in desiccated Ulva sp., whereas the cyclic PSI activity was significantly elevated, was still active at severe levels of desiccation and could be restored faster than PSII activity. Based on these results, we concluded the PSI-driven cyclic electron flow might provide desiccation tolerance and additional flexibility for the cell physiology of Ulva sp. under desiccation conditions, which might be one of the most important factors that make Ulva sp. well suited to experience daily cycles of desiccation at low tide and rehydration at high tide. PMID:21471121

  9. Efficient quantum walk on a quantum processor.

    PubMed

    Qiang, Xiaogang; Loke, Thomas; Montanaro, Ashley; Aungskunsiri, Kanin; Zhou, Xiaoqi; O'Brien, Jeremy L; Wang, Jingbo B; Matthews, Jonathan C F

    2016-01-01

    The random walk formalism is used across a wide range of applications, from modelling share prices to predicting population genetics. Likewise, quantum walks have shown much potential as a framework for developing new quantum algorithms. Here we present explicit efficient quantum circuits for implementing continuous-time quantum walks on the circulant class of graphs. These circuits allow us to sample from the output probability distributions of quantum walks on circulant graphs efficiently. We also show that solving the same sampling problem for arbitrary circulant quantum circuits is intractable for a classical computer, assuming conjectures from computational complexity theory. This is a new link between continuous-time quantum walks and computational complexity theory and it indicates a family of tasks that could ultimately demonstrate quantum supremacy over classical computers. As a proof of principle, we experimentally implement the proposed quantum circuit on an example circulant graph using a two-qubit photonics quantum processor. PMID:27146471

  10. Quantum Secure Dialogue with Quantum Encryption

    NASA Astrophysics Data System (ADS)

    Ye, Tian-Yu

    2014-09-01

    How to solve the information leakage problem has become the research focus of quantum dialogue. In this paper, in order to overcome the information leakage problem in quantum dialogue, a novel approach for sharing the initial quantum state privately between communicators, i.e., quantum encryption sharing, is proposed by utilizing the idea of quantum encryption. The proposed protocol uses EPR pairs as the private quantum key to encrypt and decrypt the traveling photons, which can be repeatedly used after rotation. Due to quantum encryption sharing, the public announcement on the state of the initial quantum state is omitted, thus the information leakage problem is overcome. The information-theoretical efficiency of the proposed protocol is nearly 100%, much higher than previous information leakage resistant quantum dialogue protocols. Moreover, the proposed protocol only needs single-photon measurements and nearly uses single photons as quantum resource so that it is convenient to implement in practice.

  11. Efficient quantum walk on a quantum processor

    PubMed Central

    Qiang, Xiaogang; Loke, Thomas; Montanaro, Ashley; Aungskunsiri, Kanin; Zhou, Xiaoqi; O'Brien, Jeremy L.; Wang, Jingbo B.; Matthews, Jonathan C. F.

    2016-01-01

    The random walk formalism is used across a wide range of applications, from modelling share prices to predicting population genetics. Likewise, quantum walks have shown much potential as a framework for developing new quantum algorithms. Here we present explicit efficient quantum circuits for implementing continuous-time quantum walks on the circulant class of graphs. These circuits allow us to sample from the output probability distributions of quantum walks on circulant graphs efficiently. We also show that solving the same sampling problem for arbitrary circulant quantum circuits is intractable for a classical computer, assuming conjectures from computational complexity theory. This is a new link between continuous-time quantum walks and computational complexity theory and it indicates a family of tasks that could ultimately demonstrate quantum supremacy over classical computers. As a proof of principle, we experimentally implement the proposed quantum circuit on an example circulant graph using a two-qubit photonics quantum processor. PMID:27146471

  12. Efficient quantum walk on a quantum processor

    NASA Astrophysics Data System (ADS)

    Qiang, Xiaogang; Loke, Thomas; Montanaro, Ashley; Aungskunsiri, Kanin; Zhou, Xiaoqi; O'Brien, Jeremy L.; Wang, Jingbo B.; Matthews, Jonathan C. F.

    2016-05-01

    The random walk formalism is used across a wide range of applications, from modelling share prices to predicting population genetics. Likewise, quantum walks have shown much potential as a framework for developing new quantum algorithms. Here we present explicit efficient quantum circuits for implementing continuous-time quantum walks on the circulant class of graphs. These circuits allow us to sample from the output probability distributions of quantum walks on circulant graphs efficiently. We also show that solving the same sampling problem for arbitrary circulant quantum circuits is intractable for a classical computer, assuming conjectures from computational complexity theory. This is a new link between continuous-time quantum walks and computational complexity theory and it indicates a family of tasks that could ultimately demonstrate quantum supremacy over classical computers. As a proof of principle, we experimentally implement the proposed quantum circuit on an example circulant graph using a two-qubit photonics quantum processor.

  13. Quantum pumping induced by disorder in one dimension

    NASA Astrophysics Data System (ADS)

    Qin, Jihong; Guo, Huaiming

    2016-07-01

    The topological property in one dimension is protected by symmetry. Based on a concrete model, we study the effect of disorder preserving or breaking the symmetry and show the nature of symmetry protecting in the one dimensional topological phase. A stable quantum pumping can be constructed within the topological model. It is shown that an integer charge is pumped across a periodic chain in a cyclic process. Furthermore we find that not only the quantum pumping is stable to on-site disorder, but also can be induced by it. These results may be realized experimentally using quasicrystals.

  14. Controlled cyclic stretch bioreactor for tissue-engineered heart valves.

    PubMed

    Syedain, Zeeshan H; Tranquillo, Robert T

    2009-09-01

    A tissue-engineered heart valve (TEHV) represents the ultimate valve replacement, especially for juvenile patients given its growth potential. To date, most TEHV bioreactors have been developed based on pulsed flow of culture medium through the valve lumen to induce strain in the leaflets. Using a strategy for controlled cyclic stretching of tubular constructs reported previously, we developed a controlled cyclic stretch bioreactor for TEHVs that leads to improved tensile and compositional properties. The TEHV is mounted inside a latex tube, which is then cyclically pressurized with culture medium. The root and leaflets stretch commensurately with the latex, the stretching being dictated by the stiffer latex and thus controllable. Medium is also perfused through the lumen at a slow rate in a flow loop to provide nutrient delivery. Fibrin-based TEHVs prepared with human dermal fibroblasts were subjected to three weeks of cyclic stretching with incrementally increasing strain amplitude. The TEHV possessed the tensile stiffness and stiffness anisotropy of leaflets from sheep pulmonary valves and could withstand cyclic pulmonary pressures with similar distension as for a sheep pulmonary artery. PMID:19473698

  15. Cyclic beta-glucans of members of the family Rhizobiaceae.

    PubMed Central

    Breedveld, M W; Miller, K J

    1994-01-01

    Cyclic beta-glucans are low-molecular-weight cell surface carbohydrates that are found almost exclusively in bacteria of the Rhizobiaceae family. These glucans are major cellular constituents, and under certain culture conditions their levels may reach up to 20% of the total cellular dry weight. In Agrobacterium and Rhizobium species, these molecules contain between 17 and 40 glucose residues linked solely by beta-(1,2) glycosidic bonds. In Bradyrhizobium species, the cyclic beta-glucans are smaller (10 to 13 glucose residues) and contain glucose linked by both beta-(1,6) and beta-(1,3) glycosidic bonds. In some rhizobial strains, the cyclic beta-glucans are unsubstituted, whereas in other rhizobia these molecules may become highly substituted with moieties such as sn-1-phosphoglycerol. To date, two genetic loci specifically associated with cyclic beta-glucan biosynthesis have been identified in Rhizobium (ndvA and ndvB) and Agrobacterium (chvA and chvB) species. Mutants with mutations at these loci have been shown to be impaired in their ability to grow in hypoosmotic media, have numerous alterations in their cell surface properties, and are also impaired in their ability to infect plants. The present review will examine the structure and occurrence of the cyclic beta-glucans in a variety of species of the Rhizobiaceae. The possible functions of these unique molecules in the free-living bacteria as well as during plant infection will be discussed. PMID:8078434

  16. Cyclic material properties tests supporting elastic-plastic analysis development

    SciTech Connect

    Hodge, S.C.; Minicucci, J.M.

    1996-11-01

    Correlation studies have shown that hardening models currently available in the ABAQUS finite element code (isotropic, kinematic) do not accurately capture the inelastic strain reversals that occur due to structural rebounding from a rapidly applied transient dynamic load. The purpose of the Cyclic Material properties Test program was to obtain response data for the first several cycles of inelastic strain reversal from a cyclic properties test. This data is needed to develop elastic-plastic analysis methods that can accurately predict strains and permanent sets in structures due to rapidly applied transient dynamic loading. Test specimens were cycled at inelastic strain levels typical of rapidly applied transient dynamic analyses (0.5% to 4.0%). In addition to the inelastic response data, cyclic material properties for high yield strength (80 ksi) steel were determined including a cyclic stress-strain curve for a stabilized specimen. Two test methods, the Incremental Step method and the Companion specimen Method, were sued to determine cyclic properties. The incrementally decreasing strain amplitudes in the first loading block of the Incremental Step method test is representative of the response of structures subjected to rapidly applied transient dynamic loads. The inelastic strain history data generated by this test program will be used to support development of a material model that can accurately predict inelastic material behavior including inelastic strain reversals. Additionally, this data can be used to verify material model enhancements to elastic-plastic finite element analysis codes.

  17. Temperature Dependent Cyclic Deformation Mechanisms in Haynes 188 Superalloy

    NASA Technical Reports Server (NTRS)

    Rao, K. Bhanu Sankara; Castelli, Michael G.; Allen, Gorden P.; Ellis, John R.

    1995-01-01

    The cyclic deformation behavior of a wrought cobalt-base superalloy, Haynes 188, has been investigated over a range of temperatures between 25 and 1000 C under isothermal and in-phase thermomechanical fatigue (TMF) conditions. Constant mechanical strain rates (epsilon-dot) of 10(exp -3)/s and 10(exp -4)/s were examined with a fully reversed strain range of 0.8%. Particular attention was given to the effects of dynamic strain aging (DSA) on the stress-strain response and low cycle fatigue life. A correlation between cyclic deformation behavior and microstructural substructure was made through detailed transmission electron microscopy. Although DSA was found to occur over a wide temperature range between approximately 300 and 750 C the microstructural characteristics and the deformation mechanisms responsible for DSA varied considerably and were dependent upon temperature. In general, the operation of DSA processes led to a maximum of the cyclic stress amplitude at 650 C and was accompanied by pronounced planar slip, relatively high dislocation density, and the generation of stacking faults. DSA was evidenced through a combination of phenomena, including serrated yielding, an inverse dependence of the maximum cyclic hardening with epsilon-dot, and an instantaneous inverse epsilon-dot sensitivity verified by specialized epsilon-dot -change tests. The TMF cyclic hardening behavior of the alloy appeared to be dictated by the substructural changes occuring at the maximum temperature in the TMF cycle.

  18. Prolonged cyclic strain inhibits human endothelial cell growth.

    PubMed

    Peyton, Kelly J; Liu, Xiao-ming; Durante, William

    2016-01-01

    The vascular endothelium is continuously exposed to cyclic mechanical strain due to the periodic change in vessel diameter as a result of pulsatile blood flow. Since emerging evidence indicates the cyclic strain plays an integral role in regulating endothelial cell function, the present study determined whether application of a physiologic regimen of cyclic strain (6% at 1 hertz) influences the proliferation of human arterial endothelial cells. Prolonged exposure of human dermal microvascular or human aortic endothelial cells to cyclic strain for up to 7 days resulted in a marked decrease in cell growth. The strain-mediated anti-proliferative effect was associated with the arrest of endothelial cells in the G2/M phase of the cell cycle, did not involve cell detachment or cytotoxicity, and was due to the induction of p21. Interestingly, the inhibition in endothelial cell growth was independent of the strain regimen since prolonged application of constant or intermittent 6% strain was also able to block endothelial cell proliferation. The ability of chronic physiologic cyclic strain to inhibit endothelial cell growth represents a previously unrecognized mechanism by which hemodynamic forces maintain these cells in a quiescent, non-proliferative state. PMID:26709656

  19. Analysis of cyclic pyrolysis products formed from amino acid monomer.

    PubMed

    Choi, Sung-Seen; Ko, Ji-Eun

    2011-11-18

    Amino acid was mixed with silica and tetramethylammonium hydroxide (TMAH) to favor pyrolysis of amino acid monomer. The pyrolysis products formed from amino acid monomer were using GC/MS and GC. 20 amino acids of alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine were analyzed. The pyrolysis products were divided into cyclic and non-cyclic products. Among the 20 amino acids, arginine, asparagine, glutamic acid, glutamine, histidine, lysine, and phenylalanine generated cyclic pyrolysis products of the monomer. New cyclic pyrolysis products were formed by isolation of amino acid monomers. They commonly had polar side functional groups to 5-, 6-, or 7-membered ring structure. Arginine, asparagine, glutamic acid, glutamine, histidine, and phenylalanine generated only 5- or 6-membered ring products. However, lysine generated both 6- and 7-membered ring compounds. Variations of the relative intensities of the cyclic pyrolysis products with the pyrolysis temperature and amino acid concentration were also investigated. PMID:21993510

  20. Cyclic mechanical reinforcement of integrin–ligand interactions

    PubMed Central

    Kong, Fang; Li, Zhenhai; Parks, William M.; Dumbauld, David W.; García, Andrés J.; Mould, A. Paul; Humphries, Martin J.; Zhu, Cheng

    2013-01-01

    Summary Cells regulate adhesion in response to internally-generated and externally-applied forces. Integrins connect the extracellular matrix to the cytoskeleton and provide cells with mechanical anchorages and signaling platforms. Here we show that cyclic forces applied to a fibronectin–integrin α5β1 bond switch the bond from a short-lived state with 1-s lifetime to a long-lived state with 100-s lifetime. We term this phenomenon “cyclic mechanical reinforcement” as the bond strength remembers the history of force application, accumulates over repeated cycles, but does not require force to be sustained. Cyclic mechanical reinforcement strengthens the fibronectin–integrin α5β1 bond through the RGD binding site of the ligand with the synergy binding site greatly facilitating the process. A flexible integrin hybrid domain is also important for cyclic mechanical reinforcement. Our results reveal a mechanical regulation of receptor–ligand interactions and identify a molecular mechanism for cell adhesion strengthening by cyclic forces. PMID:23416109

  1. Mechanical annealing under low-amplitude cyclic loading in micropillars

    NASA Astrophysics Data System (ADS)

    Cui, Yi-nan; Liu, Zhan-li; Wang, Zhang-jie; Zhuang, Zhuo

    2016-04-01

    Mechanical annealing has been demonstrated to be an effective method for decreasing the overall dislocation density in submicron single crystal. However, simultaneously significant shape change always unexpectedly happens under extremely high monotonic loading to drive the pre-existing dislocations out of the free surfaces. In the present work, through in situ TEM experiments it is found that cyclic loading with low stress amplitude can drive most dislocations out of the submicron sample with virtually little change of the shape. The underlying dislocation mechanism is revealed by carrying out discrete dislocation dynamic (DDD) simulations. The simulation results indicate that the dislocation density decreases within cycles, while the accumulated plastic strain is small. By comparing the evolution of dislocation junction under monotonic, cyclic and relaxation deformation, the cumulative irreversible slip is found to be the key factor of promoting junction destruction and dislocation annihilation at free surface under low-amplitude cyclic loading condition. By introducing this mechanics into dislocation density evolution equations, the critical conditions for mechanical annealing under cyclic and monotonic loadings are discussed. Low-amplitude cyclic loading which strengthens the single crystal without seriously disturbing the structure has the potential applications in the manufacture of defect-free nano-devices.

  2. Analysis of cyclic combustion of the coal-water suspension

    NASA Astrophysics Data System (ADS)

    Kijo-Kleczkowska, Agnieszka

    2011-04-01

    Combustion technology of the coal-water suspension creates a number of new possibilities to organize the combustion process fulfilling contemporary requirements, e.g. in the environment protection. Therefore the in-depth analysis is necessary to examine the technical application of coal as a fuel in the form of suspension. The research undertakes the complex investigations of the continuous coal-water suspension as well as cyclic combustion. The cyclic nature of fuel combustion results from the movement of the loose material in the flow contour of the circulating fluidized bed (CFB): combustion chamber, cyclone and downcomer. The experimental results proved that the cyclic change of oxygen concentration around fuel, led to the vital change of both combustion mechanisms and combustion kinetics. The mathematical model of the process of fuel combustion has been presented. Its original concept is based on the allowance for cyclic changes of concentrations of oxygen around the fuel. It enables the prognosis for change of the surface and the centre temperatures as well as mass loss of the fuel during combustion in air, in the fluidized bed and during the cyclic combustion.

  3. Cyclic stretch of airway epithelium inhibits prostanoid synthesis.

    PubMed

    Savla, U; Sporn, P H; Waters, C M

    1997-11-01

    Airway epithelial cells (AEC) metabolize arachidonic acid (AA) to biologically active eicosanoids, which contribute to regulation of airway smooth muscle tone and inflammatory responses. Although in vivo the airways undergo cyclical stretching during ventilation, the effect of cyclic stretch on airway epithelial AA metabolism is unknown. In this study, cat and human AEC were grown on flexible membranes and were subjected to cyclic stretch using the Flexercell strain unit. Cyclic stretch downregulated synthesis of prostaglandin (PG) E2, PGI2, and thromboxane A2 by both cell types in a frequency-dependent manner. The percent inhibition of prostanoid synthesis in both cell types ranged from 53 +/- 7 to 75 +/- 8% (SE; n = 4 and 5, respectively). Treatment of cat AEC with exogenous AA (10 micrograms/ml) had no effect on the stretch-induced inhibition of PGE2 synthesis, whereas treatment with exogenous PGH2 (10 micrograms/ml) overcame the stretch-induced decrease in PGE2 production. These results indicate that stretch inhibits prostanoid synthesis by inactivating cyclooxygenase. When cells were pretreated with the antioxidants catalase (100 micrograms/ml, 150 U/ml) and N-acetylcysteine (1 mM), there was a partial recovery of eicosanoid production, suggesting that cyclic stretch-induced inactivation of cyclooxygenase is oxidant mediated. These results may have important implications for inflammatory diseases in which airway mechanics are altered. PMID:9374729

  4. Quantum nonlocality

    SciTech Connect

    Stapp, H.P.

    1988-04-01

    It is argued that the validity of the predictions of quantum theory in certain spin-correlation experiments entails a violation of Einstein's locality idea that no causal influence can act outside the forward light cone. First, two preliminary arguments suggesting such a violation are reviewed. They both depend, in intermediate stages, on the idea that the results of certain unperformed experiments are physically determinate. The second argument is entangled also with the problem of the meaning of physical reality. A new argument having neither of these characteristics is constructed. It is based strictly on the orthodox ideas of Bohr and Heisenberg, and has no realistic elements, or other ingredients, that are alien to orthodox quantum thinking.

  5. Quantum oligopoly

    NASA Astrophysics Data System (ADS)

    Lo, C. F.; Kiang, D.

    2003-12-01

    Based upon a modification of Li et al.'s "minimal" quantization rules (Phys. Lett. A306(2002) 73), we investigate the quantum version of the Cournot and Bertrand oligopoly. In the Cournot oligopoly, the profit of each of the N firms at the Nash equilibrium point rises monotonically with the measure of the quantum entanglement. Only at maximal entanglement, however, does the Nash equilibrium point coincide with the Pareto optimal point. In the Bertrand case, the Bertrand Paradox remains for finite entanglement (i.e., the perfectly competitive stage is reached for any N>=2), whereas with maximal entanglement each of the N firms will still have a non-zero shared profit. Hence, the Bertrand Paradox is completely resolved. Furthermore, a perfectly competitive market is reached asymptotically for N → ∞ in both the Cournot and Bertrand oligopoly.

  6. Geometric quantum phase for displaced states for a particle with an induced electric dipole moment

    NASA Astrophysics Data System (ADS)

    Lemos de Melo, J.; Bakke, K.; Furtado, C.

    2016-07-01

    Basing on the analogue Landau levels for a neutral particle possessing an induced electric dipole moment, we show that displaced states can be built in the presence of electric and magnetic fields. Besides, the Berry phase associated with these displaced quantum states is obtained by performing an adiabatic cyclic evolution in series of paths in parameter space.

  7. Adiabatically implementing quantum gates

    SciTech Connect

    Sun, Jie; Lu, Songfeng Liu, Fang

    2014-06-14

    We show that, through the approach of quantum adiabatic evolution, all of the usual quantum gates can be implemented efficiently, yielding running time of order O(1). This may be considered as a useful alternative to the standard quantum computing approach, which involves quantum gates transforming quantum states during the computing process.

  8. Quantum English auctions

    NASA Astrophysics Data System (ADS)

    Piotrowski, Edward W.; Sładkowski, Jan

    2003-02-01

    We continue the analysis of quantum-like description of markets and economics. The approach has roots in the recently developed quantum game theory and quantum computing. The present paper is devoted to quantum English auction which we consider as a special class of quantum market games. The approach allows to calculate profit intensities for various possible strategies.

  9. Quantum Mechanics

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    A development of quantum theory that was initiated in the 1920s by Werner Heisenberg (1901-76) and Erwin Schrödinger (1887-1961). The theory drew on a proposal made in 1925 Prince Louis de Broglie (1892-1987), that particles have wavelike properties (the wave-particle duality) and that an electron, for example, could in some respects be regarded as a wave with a wavelength that depended on its mo...

  10. Quantum Physics

    NASA Astrophysics Data System (ADS)

    Rae, Alastair

    2012-03-01

    Preface to the second edition; Preface to the first edition; 1. Quantum physics; 2. Which way are the photons pointing?; 3. What can be hidden in a pair of photons?; 4. Wonderful Copenhagen?; 5. Is it all in the mind?; 6. Many worlds; 7. Is it a matter of size?; 8. Backwards and forwards; 9. Only one way forward?; 10. Can we be consistent?; 11. Illusion or reality?; Further reading.

  11. Cyclicity in the fossil record mirrors rock outcrop area

    PubMed Central

    Smith, Andrew B; McGowan, Alistair J

    2005-01-01

    In a recent article, Rohde & Muller (Rohde & Muller 2005 Nature 434, 208–210) identified a strong 62 Myr cyclicity in the history of marine diversity through the Phanerozoic. The data they presented were highly convincing, yet they were unable to explain what process might have generated this pattern. A significant correlation between observed genus-level diversity (after removal of long-term trends) and the amount of marine sedimentary rock measured at a surface outcrop in Western Europe is demonstrated. This suggests that cyclicity originates from long-term changes in sedimentary depositional and erosional regimes, and raises the strong possibility that the cyclicity apparent in the record of marine fossils is not a biological signal but a sampling signal. PMID:17148228

  12. Application Of Shakedown Analysis To Cyclic Creep Damage Limits

    SciTech Connect

    Carter, Peter; Jetter, Robert I; Sham, Sam

    2012-01-01

    Shakedown analysis may be used to provide a conservative estimate of local rupture and hence cyclic creep damage for use in a creep-fatigue assessment. The shakedown analysis is based on an elastic-perfectly plastic material with a temperature-dependent pseudo yield stress defined to guarantee that a shakedown solution exists which does not exceed rupture stress and temperature for a defined life. The ratio of design life to the estimated maximum cyclic life is the shakedown creep damage. The methodology does not require stress classification and is also applicable to cycles over the full range of temperature above and below the creep regime. Full cyclic creep and damage analysis is the alternative when shakedown analysis appears to be excessively conservative.

  13. Saddle-Shaped Cyclic Indole Tetramers: 3D Electroactive Molecules.

    PubMed

    Ruiz, Constanza; Monge, Ángeles; Gutiérrez-Puebla, Enrique; Alkorta, Ibon; Elguero, José; Navarrete, Juan T López; Ruiz Delgado, M Carmen; Gómez-Lor, Berta

    2016-07-18

    We present a joint theoretical and experimental study of a series of cyclic indole tetramers aimed at understanding the fundamental electronic properties of this 3D platform and evaluating its potential in the construction of new semiconductors. To this end, we combined absorption and Raman spectroscopy, cyclic voltammetry, and spectroelectrochemistry with DFT calculations. Our results suggest that this platform can be easily and reversibly oxidized. Additionally, it has a HOMO that matches very well with the workfunction of gold, therefore charge injection from a gold electrode is expected to occur without significant barriers. Interestingly, the cyclic tetraindoles allow for good electron delocalization in spite of their saddle-shaped structures. The steric constraints introduced by N-substitution significantly inhibits ring inversion of the central cyclooctatetraene unit, whereas it only barely affects the optical and electrochemical properties (a slightly higher oxidation potential and a blueshifted absorption upon alkylation are observed). PMID:27320301

  14. Low Severity Coal Liquefaction Promoted by Cyclic Olefins

    SciTech Connect

    Christine W. Curtis

    1998-04-09

    The development of the donor solvent technology for coal liquefaction has drawn a good deal of attention over the last three decades. The search for better hydrogen donors led investigators to a class of compounds known as cyclic olefins. Cyclic olefins are analogues of the conventional hydroaromatic donor species but do not contain aromatic rings. The cyclic olefins are highly reactive compounds which readily release their hydrogen at temperatures of 200 C or higher. Considerable effort has been o expended toward understanding the process of hydrogen donation. Most of this work was conducted in bomb reactors, with product analysis being carried out after the reaction was complete. Efforts directed towards fundamental studies of these reactions in situ are rare. The current work employs a high temperature and high pressure infrared cell to monitor in situ the concentrations of reactants and products during hydrogen release from hydrogen donor compounds.

  15. Fatigue crack growth under general-yielding cyclic-loading

    NASA Technical Reports Server (NTRS)

    Minzhong, Z.; Liu, H. W.

    1986-01-01

    In low cycle fatigue, cracks are initiated and propagated under general yielding cyclic loading. For general yielding cyclic loading, Dowling and Begley have shown that fatigue crack growth rate correlates well with the measured delta J. The correlation of da/dN with delta J was also studied by a number of other investigators. However, none of thse studies have correlated da/dN with delta J calculated specifically for the test specimens. Solomon measured fatigue crack growth in specimens in general yielding cyclic loading. The crack tips fields for Solomon's specimens are calculated using the finite element method and the J values of Solomon's tests are evaluated. The measured crack growth rate in Solomon's specimens correlates very well with the calculated delta J.

  16. On the connection between multigrid and cyclic reduction

    NASA Technical Reports Server (NTRS)

    Merriam, M. L.

    1984-01-01

    A technique is shown whereby it is possible to relate a particular multigrid process to cyclic reduction using purely mathematical arguments. This technique suggest methods for solving Poisson's equation in 1-, 2-, or 3-dimensions with Dirichlet or Neumann boundary conditions. In one dimension the method is exact and, in fact, reduces to cyclic reduction. This provides a valuable reference point for understanding multigrid techniques. The particular multigrid process analyzed is referred to here as Approximate Cyclic Reduction (ACR) and is one of a class known as Multigrid Reduction methods in the literature. It involves one approximation with a known error term. It is possible to relate the error term in this approximation with certain eigenvector components of the error. These are sharply reduced in amplitude by classical relaxation techniques. The approximation can thus be made a very good one.

  17. A fluorescence polarization assay for cyclic nucleotide phosphodiesterases.

    PubMed

    Huang, Wei; Zhang, Yan; Sportsman, J Richard

    2002-06-01

    Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of the 3'-ester bond of cyclic AMP (cAMP) and cyclic GMP (cGMP), important second messengers in the transduction of a variety of extracellular signals. There is growing interest in the study of PDEs as drug targets for novel therapeutics. We describe the development of a homogeneous fluorescence polarization assay for PDEs based on the strong binding of PDE reaction products (i.e., AMP or GMP) onto modified nanoparticles through interactions with immobilized trivalent metal cations. This assay technology (IMAP) is applicable to both cAMP- and cGMP-specific PDEs. Results of the assay in 384- and 1536-well microplates are presented. PMID:12097184

  18. Development of a viscoelastic continuum damage model for cyclic loading

    NASA Astrophysics Data System (ADS)

    Sullivan, R. W.

    2008-12-01

    A previously developed spectrum model for linear viscoelastic behavior of solids is used to describe the rate-dependent damage growth of a time dependent material under cyclic loading. Through the use of the iterative solution of a special Volterra integral equation, the cyclic strain history is described. The spectrum-based model is generalized for any strain rate and any uniaxial load history to formulate the damage function. Damage evolution in the body is described through the use of a rate-type evolution law which uses a pseudo strain to express the viscoelastic constitutive equation with damage. The resulting damage function is used to formulate a residual strength model. The methodology presented is demonstrated by comparing the peak values of the computed cyclic strain history as well as the residual strength model predictions to the experimental data of a polymer matrix composite.

  19. Cyclic AMP system in muscle tissue during prolonged hypokinesia

    NASA Technical Reports Server (NTRS)

    Antipenko, Y. A.; Bubeyev, Y. A.; Korovkin, B. F.; Mikhaleva, N. P.

    1980-01-01

    Components of the cyclic Adenosine-cyclic-35-monophosphate (AMP) system in the muscle tissue of white rats were studied during 70-75 days of hypokinesia, created by placing the animals in small booths which restricted their movements, and during the readaptation period. In the initial period, cyclic AMP levels and the activities of phosphodiesterase and adenylate cyclase in muscle tissue were increased. The values for these indices were roughly equal for controls and experimental animals during the adaptation period, but on the 70th day of the experiment cAMP levels dropped, phosphodiesterase activity increased, and the stimulative effect of epinephrine on the activity of adenylate cyclase decreased. The indices under study normalized during the readaptation period.

  20. Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles

    SciTech Connect

    Screen, Hazel R.C. . E-mail: H.R.C.Screen@qmul.ac.uk; Shelton, Julia C.; Bader, Dan L.; Lee, David A.

    2005-10-21

    Mechanical stimulation has been implicated as an important regulatory factor in tendon homeostasis. In this study, a custom-designed tensile loading system was used to apply controlled mechanical stimulation to isolated tendon fascicles, in order to examine the effects of 5% cyclic tensile strain at 1 Hz on cell proliferation and matrix synthesis. Sample viability and gross structural composition were maintained over a 24 h loading period. Data demonstrated no statistically significant differences in cell proliferation or glycosaminoglycan production, however, collagen synthesis was upregulated with the application of cyclic tensile strain over the 24 h period. Moreover, a greater proportion of the newly synthesised matrix was retained within the sample after loading. These data provide evidence of altered anabolic activity within tendon in response to mechanical stimuli, and suggest the importance of cyclic tensile loading for the maintenance of the collagen hierarchy within tendon.

  1. Efficient Quantum Information Processing via Quantum Compressions

    NASA Astrophysics Data System (ADS)

    Deng, Y.; Luo, M. X.; Ma, S. Y.

    2016-01-01

    Our purpose is to improve the quantum transmission efficiency and reduce the resource cost by quantum compressions. The lossless quantum compression is accomplished using invertible quantum transformations and applied to the quantum teleportation and the simultaneous transmission over quantum butterfly networks. New schemes can greatly reduce the entanglement cost, and partially solve transmission conflictions over common links. Moreover, the local compression scheme is useful for approximate entanglement creations from pre-shared entanglements. This special task has not been addressed because of the quantum no-cloning theorem. Our scheme depends on the local quantum compression and the bipartite entanglement transfer. Simulations show the success probability is greatly dependent of the minimal entanglement coefficient. These results may be useful in general quantum network communication.

  2. Quantum Information Theory for Quantum Communication

    NASA Astrophysics Data System (ADS)

    Koashi, Masato

    This chapter gives a concise description of the fundamental concepts of quantum information and quantum communication, which is pertinent to the discussions in the subsequent chapters. Beginning with the basic set of rules that dictate quantum mechanics, the chapter explains the most general ways to describe quantum states, measurements, and state transformations. Convenient mathematical tools are also presented to provide an intuitive picture of a qubit, which is the simplest unit of quantum information. The chapter then elaborates on the distinction between quantum communication and classical communication, with emphasis on the role of quantum entanglement as a communication resource. Quantum teleportation and dense coding are then explained in the context of optimal resource conversions among quantum channels, classical channels, and entanglement.

  3. Quantum Locality?

    SciTech Connect

    Stapp, Henry

    2011-11-10

    Robert Griffiths has recently addressed, within the framework of a ‘consistent quantum theory’ (CQT) that he has developed, the issue of whether, as is often claimed, quantum mechanics entails a need for faster-than-light transfers of information over long distances. He argues, on the basis of his examination of certain arguments that claim to demonstrate the existence of such nonlocal influences, that such influences do not exist. However, his examination was restricted mainly to hidden-variable-based arguments that include in their premises some essentially classical-physics-type assumptions that are fundamentally incompatible with the precepts of quantum physics. One cannot logically prove properties of a system by attributing to the system properties alien to that system. Hence Griffiths’ rejection of hidden-variable-based proofs is logically warranted. Griffiths mentions the existence of a certain alternative proof that does not involve hidden variables, and that uses only macroscopically described observable properties. He notes that he had examined in his book proofs of this general kind, and concluded that they provide no evidence for nonlocal influences. But he did not examine the particular proof that he cites. An examination of that particular proof by the method specified by his ‘consistent quantum theory’ shows that the cited proof is valid within that restrictive framework. This necessary existence, within the ‘consistent’ framework, of long range essentially instantaneous influences refutes the claim made by Griffiths that his ‘consistent’ framework is superior to the orthodox quantum theory of von Neumann because it does not entail instantaneous influences. An added section responds to Griffiths’ reply, which cites a litany of ambiguities that seem to restrict, devastatingly, the scope of his CQT formalism, apparently to buttress his claim that my use of that formalism to validate the nonlocality theorem is flawed. But the

  4. Post-cyclic transmission in Acanthocephalus tumescens (Acanthocephala: Echinorhynchidae).

    PubMed

    Rauque, Carlos A; Semenas, Liliana G; Viozzi, Gustavo P

    2002-01-01

    The aim of this study was to investigate the post-cyclic transmission of Acanthocephalus tumescens (von Linstow, 1896) from Galaxias maculatus Jenyns to Oncorhynchus mykiss (Walbaum). Wild G. maculatus naturally infected with A. tumescens were fed to cultured rainbow trout, which were sacrificed at the second, third and fourth weeks post infection. Normally attached male and female acanthocephalans were recovered alive from the intestine of rainbow trout. Parasites survive at least four weeks post infection, growing and attaining full sexual maturity. Prevalence and mean intensity generally decreased after infection. A. tumescens is the eighth acanthocephalan species in which post-cyclic transmission has been proven. PMID:12194485

  5. Monotonic and cyclic fatigue properties of automotive aluminum alloys

    SciTech Connect

    Wong, W.A.

    1984-01-01

    Monotonic and strain-controlled fatigue tests were conducted on 2014-T6, 6061-T6 and 7175-T73 hand-forgings, 5052-H32 and 6061-T6 sheet, and a 1983/84 production Chevrolet Corvette upper-control-arm-pivot shaft (UCAPS) cold-forged from 5454-H12 and 6061-T4 rolled rod (the 6061 UCAPS was artificially-aged to the -T6 temper, after forging). Various monotonic and cyclic fatigue stress-strain material properties are presented. The responses of the various alloys and product-forms in terms of cyclic hardening or softening are described.

  6. Cyclic behavior of turbine disk alloys at 650 C

    NASA Technical Reports Server (NTRS)

    Cowles, B. A.; Sims, D. L.; Warren, J. R.; Miner, R. V., Jr.

    1980-01-01

    Five gas turbine disk alloys representing a range of strengths and processing methods were tested for resistance to both cyclic crack initiation and propagation at 650 C using a 0.33 Hz fatigue cycle and a cycle incorporating a 900 s tensile dwell. At the low strain ranges pertinent to disks, resistance to crack initiation increased with increasing tensile yield strength among the alloys, though the advantage was somewhat smaller for the creep fatigue cycle. Cyclic crack growth resistance, however, decreased with increasing strength and very markedly so for the dwell cycle.

  7. Comparison of continuous and cyclic pumping from a well.

    PubMed

    Kawecki, M W

    2001-01-01

    Two practically applicable pumping patterns for wells are: (1) continuous pumping at a sustainable constant rate; and (2) pumping at a sustainable constant rate for a fixed period every day (cyclic pumping). Theoretical analysis shows that with the cyclic pumping pattern the pump can be run at a higher rate than with continuous pumping. However continuous pumping at the maximum continuously sustainable constant rate produces considerably more water. If the objective is to produce as much water as possible, it is important to use a pump designed for running at the maximum continuously sustainable rate. PMID:11447863

  8. Polymerization of the cyclic pyrophosphates of nucleosides and their analogues

    NASA Technical Reports Server (NTRS)

    Tohidi, Mahrokh; Orgel, Leslie E.

    1990-01-01

    When 2-prime-deoxythymidine 3-prime, 5-prime-cyclic diphosphate, or the cyclic pyrophosphates of the acyclic nucleoside analogs II and IV are heated to 65-85 C in the presence of imidazole, oligomers with lengths up to 20-30 are formed in excellent yield. This reaction provides a useful source of oligomers for use as templates in aqueous condensation reactions. In the absence of evidence to the contrary, it is assumed that the oligomers are atactic. The potential significance of this reaction in prebiotic chemistry is discussed.

  9. The Cyclic AMP Phenotype of Fragile X and Autism

    PubMed Central

    Kelley, Daniel J; Bhattacharyya, Anita; Lahvis, Garet P; Yin, Jerry CP; Malter, Jim; Davidson, Richard J

    2008-01-01

    Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism. PMID:18601949

  10. Nonlinear behavior of shells of revolution under cyclic loading.

    NASA Technical Reports Server (NTRS)

    Levine, H. S.; Armen, H., Jr.; Winter, R.; Pifko, A.

    1973-01-01

    A large deflection elastic-plastic analysis is presented applicable to orthotropic axisymmetric plates and shells of revolution subjected to monotonic and cyclic loading conditions. The analysis is based on the finite-element method. It employs a new higher order, fully compatible, doubly curved orthotropic shell-of-revolution element using cubic Hermitian expansions for both meridional and normal displacements. Both perfectly plastic and strain hardening behavior are considered. Strain hardening is incorporated through use of the Prager-Ziegler kinematic hardening theory, which predicts an ideal Bauschinger effect. Numerous sample problems involving monotonic and cyclic loading conditions are analyzed.

  11. Controls on Precambrian sea level change and sedimentary cyclicity

    NASA Astrophysics Data System (ADS)

    Eriksson, P. G.; Catuneanu, O.; Nelson, D. R.; Popa, M.

    2005-04-01

    Although uniformitarianism applies in a general sense to the controls on relative and global sea level change, some influences thereon were more prominent in the Precambrian. Short-term base level change due to waves and tides may have been enhanced due to possibly more uniform circulation systems on wide, low gradient Precambrian shelves. The lack of evidence for global glacial events in the Precambrian record implies that intraplate stresses and cyclic changes to Earth's geoid were more likely explanations for third-order sea level change than glacio-eustasy. Higher heat flow in the earlier Precambrian may have led to more rapid tectonic plate formation, transport and destruction, along with an increased role for hot spots, aseismic ridges and mantle plumes (superplumes), all of which may have influenced cyclic sedimentation within the ocean basins. A weak cyclicity in the occurrence of plume events has an approximate duration comparable to that of first-order (supercontinental cycle) sea level change. Second-order cyclicity in the Precambrian largely reflects the influences of thermal epeirogeny, changes to mid-ocean ridge volume as well as to ridge growth and decay rates, and cratonic marginal downwarping concomitant with either sediment loading or extensional tectonism. Third-order cycles of sea level change in the Precambrian also reflected cyclic loading/unloading within flexural foreland basin settings, and filling/deflation of magma chambers associated with island arc evolution. The relatively limited number of studies of Precambrian sequence stratigraphy allows some preliminary conclusions to be drawn on duration of the first three orders of cyclicity. Archaean greenstone basins appear to have had first- and second-order cycle durations analogous to Phanerozoic equivalents, supporting steady state tectonics throughout Earth history. In direct contrast, however, preserved basin-fills from Neoarchaean-Palaeoproterozoic cratonic terranes have first- and

  12. Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety.

    PubMed

    Beer, B; Chasin, M; Clody, D E; Vogel, J R

    1972-04-28

    Drugs that reduce anxiety may be mediated by cyclic adenosine monophosphate in the brain because (i) potent anxiety-reducing drugs are also potent inhibitors of brain phosphodiesterase activity; (ii) dibutyryl cyclic adenosine monophosphate has the ability to reduce anxiety; (iii) the methylxanthines show significant anxiety-reducing effects; (iv) theophylline and chlordiazepoxide produce additive anxiety-reducing activity; and (v) there is a significant correlation between the anxiety-reducing property of drugs and their ability to inhibit phosphodiesterase activity in the brain. PMID:4402069

  13. The Vomiting Patient: Small Bowel Obstruction, Cyclic Vomiting, and Gastroparesis.

    PubMed

    Nagarwala, Jumana; Dev, Sharmistha; Markin, Abraham

    2016-05-01

    Vomiting and abdominal pain are common in patients in the emergency department. This article focuses on small bowel obstruction (SBO), cyclic vomiting, and gastroparesis. Through early diagnosis and appropriate management, the morbidity and mortality associated with SBOs can be significantly reduced. Management of SBOs involves correction of physiologic and electrolyte disturbances, bowel rest and removing the source of the obstruction. Treatment of acute cyclic vomiting is primarily directed at symptom control, volume and electrolyte repletion, and appropriate specialist follow-up. The mainstay of therapy for gastroparesis is metoclopramide. PMID:27133244

  14. Quantum probability and quantum decision-making.

    PubMed

    Yukalov, V I; Sornette, D

    2016-01-13

    A rigorous general definition of quantum probability is given, which is valid not only for elementary events but also for composite events, for operationally testable measurements as well as for inconclusive measurements, and also for non-commuting observables in addition to commutative observables. Our proposed definition of quantum probability makes it possible to describe quantum measurements and quantum decision-making on the same common mathematical footing. Conditions are formulated for the case when quantum decision theory reduces to its classical counterpart and for the situation where the use of quantum decision theory is necessary. PMID:26621989

  15. Interpreting quantum discord through quantum state merging

    SciTech Connect

    Madhok, Vaibhav; Datta, Animesh

    2011-03-15

    We present an operational interpretation of quantum discord based on the quantum state merging protocol. Quantum discord is the markup in the cost of quantum communication in the process of quantum state merging, if one discards relevant prior information. Our interpretation has an intuitive explanation based on the strong subadditivity of von Neumann entropy. We use our result to provide operational interpretations of other quantities like the local purity and quantum deficit. Finally, we discuss in brief some instances where our interpretation is valid in the single-copy scenario.

  16. Quantum coherence and correlations in quantum system

    PubMed Central

    Xi, Zhengjun; Li, Yongming; Fan, Heng

    2015-01-01

    Criteria of measure quantifying quantum coherence, a unique property of quantum system, are proposed recently. In this paper, we first give an uncertainty-like expression relating the coherence and the entropy of quantum system. This finding allows us to discuss the relations between the entanglement and the coherence. Further, we discuss in detail the relations among the coherence, the discord and the deficit in the bipartite quantum system. We show that, the one-way quantum deficit is equal to the sum between quantum discord and the relative entropy of coherence of measured subsystem. PMID:26094795

  17. Twisted Quantum Toroidal Algebras

    NASA Astrophysics Data System (ADS)

    Jing, Naihuan; Liu, Rongjia

    2014-09-01

    We construct a principally graded quantum loop algebra for the Kac-Moody algebra. As a special case a twisted analog of the quantum toroidal algebra is obtained together with the quantum Serre relations.

  18. Quantum differential cryptanalysis

    NASA Astrophysics Data System (ADS)

    Zhou, Qing; Lu, Songfeng; Zhang, Zhigang; Sun, Jie

    2015-06-01

    In this paper, we propose a quantum version of the differential cryptanalysis which offers a quadratic speedup over the existing classical one and show the quantum circuit implementing it. The quantum differential cryptanalysis is based on the quantum minimum/maximum-finding algorithm, where the values to be compared and filtered are obtained by calling the quantum counting algorithm. Any cipher which is vulnerable to the classical differential cryptanalysis based on counting procedures can be cracked more quickly under this quantum differential attack.

  19. Relativistic quantum cryptography

    SciTech Connect

    Molotkov, S. N.

    2011-03-15

    A new protocol of quantum key distribution is proposed to transmit keys through free space. Along with quantum-mechanical restrictions on the discernibility of nonorthogonal quantum states, the protocol uses additional restrictions imposed by special relativity theory. Unlike all existing quantum key distribution protocols, this protocol ensures key secrecy for a not strictly one-photon source of quantum states and an arbitrary length of a quantum communication channel.

  20. Discrete Symmetries and 1/3-Quantum Vortices in Condensates of F=2 Cold Atoms

    SciTech Connect

    Semenoff, Gordon W.; Zhou, Fei

    2007-03-09

    In this Letter we study discrete symmetries of mean field manifolds of condensates of F=2 cold atoms, and various unconventional quantum vortices. Discrete quaternion symmetries result in two species of spin defects that can only appear in integer vortices while cyclic symmetries are found to result in a phase shift of 2{pi}/3 (or 4{pi}/3) and therefore 1/3- (or 2/3-) quantum vortices in condensates. We also briefly discuss 1/3-quantum vortices in condensates of trimers.

  1. Parametric analysis of a passive cyclic control device for helicopters

    NASA Technical Reports Server (NTRS)

    Kumagai, H.

    1984-01-01

    A parametric study of a passive device which provides a cyclic longitudinal control moment for a helicopter rotor was performed. It utilizes a rotor blade tip which is structurally decoupled from the blade inboard section. This rotor configuration is generally called the Free-Tip Rotor. A two dimensional numerical model was used to review the Constant Lift Tip Rotor, a predecessor of the current configuration, and then the same model was applied to the Passive Cyclic Control Device. The Constant Lift Tip was proven to have the ability to suppress the vibratory lift loading on the tip around the azimuth and to eliminate a significant negative lift peak on the advancing tip. The Passive Cyclic Control Device showed a once-per-revolution lift oscillation with a large amplitude, while minimizing the higher harmonic terms of the lift oscillation. This once-per-revolution oscillation results in the cyclic moment to trim the rotor longitudinally. A rotor performance analysis was performed by a three dimensional numerical model. It indicated that the vortices shed from the junction between the tip and the inboard section has a strong influence on the tip, and it may severely limit the tip performance. It was also shown that the Free-Tip allows the inboard section to have a larger twist, which results in a better performance.

  2. Serinocyclins A and B, Cyclic Heptapeptides from Metarhizium anisopliae

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Two new cyclic heptapeptides, serinocyclins A (1) and B (2), were isolated from conidia of the entomopathogenic fungus Metarhizium anisopliae. Structures were elucidated by a combination of mass spectrometric, NMR, and X-ray diffraction techniques. Serinocyclin A (1) contains three serine units, a...

  3. Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Screening natural product extracts from National Cancer Institute Open Repository for antifungal discovery afforded hits for bioassay-guided fractionation. Upon LC-MS analysis of column fractions with antifungal activities to generate information on chemical structure, two new cyclic hexapeptides, m...

  4. Skill Retention and Relearning--A Proposed Cyclical Model.

    ERIC Educational Resources Information Center

    Ginzburg, S.; Dar-El, E. M.

    2000-01-01

    The relationship between relearning and retention was examined during refresher training for 53 Israeli soldiers operating an electronic system. The longer the training interval, the lower the operator's performance level. Partial simulation was suitable for retraining in complex tasks. A cyclical behavior model of learning, forgetting, and…

  5. Syntheses of Cyclic Guanidine-Containing Natural Products

    PubMed Central

    Ma, Yuyong; De, Saptarshi; Chen, Chuo

    2014-01-01

    Naturally occurring guanidine derivatives frequently display medicinally useful properties. Among them, the higher order pyrrole-imidazole alkaloids, the dragmacidins, the crambescidins/batzelladines, and the saxitoxins/tetradotoxins have stimulated the development of many new synthetic methods over the past decades. We provide here an overview of the syntheses of these cyclic guanidine-containing natural products. PMID:25684829

  6. Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness.

    PubMed

    Li, Dan; Paterson, David J

    2016-07-15

    Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are now recognized as important intracellular signalling molecules that modulate cardiac sympatho-vagal balance in the progression of heart disease. Recent studies have identified that a significant component of autonomic dysfunction associated with several cardiovascular pathologies resides at the end organ, and is coupled to impairment of cyclic nucleotide targeted pathways linked to abnormal intracellular calcium handling and cardiac neurotransmission. Emerging evidence also suggests that cyclic nucleotide coupled phosphodiesterases (PDEs) play a key role limiting the hydrolysis of cAMP and cGMP in disease, and as a consequence this influences the action of the nucleotide on its downstream biological target. In this review, we illustrate the action of nitric oxide-CAPON signalling and brain natriuretic peptide on cGMP and cAMP regulation of cardiac sympatho-vagal transmission in hypertension and ischaemic heart disease. Moreover, we address how PDE2A is now emerging as a major target that affects the efficacy of soluble/particulate guanylate cyclase coupling to cGMP in cardiac dysautonomia. PMID:26915722

  7. Geometric angles in cyclic evolutions of a classical system

    NASA Technical Reports Server (NTRS)

    Bhattacharjee, A.; Sen, Tanaji

    1988-01-01

    A perturbative method, using Lie transforms, is given for calculating the Hannay angle for slow, cyclic evolutions of a classical system, taking into account the finite rate of change of the Hamiltonian. The method is applied to the generalized harmonic oscillator. The classical Aharonov-Anandan angle is also calculated. The interpretational ambiguity in the definitions of geometrical angles is discussed.

  8. Unfolding the fold of cyclic cysteine-rich peptides

    PubMed Central

    Shehu, Amarda; Kavraki, Lydia E.; Clementi, Cecilia

    2008-01-01

    We propose a method to extensively characterize the native state ensemble of cyclic cysteine-rich peptides. The method uses minimal information, namely, amino acid sequence and cyclization, as a topological feature that characterizes the native state. The method does not assume a specific disulfide bond pairing for cysteines and allows the possibility of unpaired cysteines. A detailed view of the conformational space relevant for the native state is obtained through a hierarchic multi-resolution exploration. A crucial feature of the exploration is a geometric approach that efficiently generates a large number of distinct cyclic conformations independently of one another. A spatial and energetic analysis of the generated conformations associates a free-energy landscape to the explored conformational space. Application to three long cyclic peptides of different folds shows that the conformational ensembles and cysteine arrangements associated with free energy minima are fully consistent with available experimental data. The results provide a detailed analysis of the native state features of cyclic peptides that can be further tested in experiment. PMID:18287281

  9. How turbulence regulates biodiversity in systems with cyclic competition

    NASA Astrophysics Data System (ADS)

    Grošelj, Daniel; Jenko, Frank; Frey, Erwin

    2015-03-01

    Cyclic, nonhierarchical interactions among biological species represent a general mechanism by which ecosystems are able to maintain high levels of biodiversity. However, species coexistence is often possible only in spatially extended systems with a limited range of dispersal, whereas in well-mixed environments models for cyclic competition often lead to a loss of biodiversity. Here we consider the dispersal of biological species in a fluid environment, where mixing is achieved by a combination of advection and diffusion. In particular, we perform a detailed numerical analysis of a model composed of turbulent advection, diffusive transport, and cyclic interactions among biological species in two spatial dimensions and discuss the circumstances under which biodiversity is maintained when external environmental conditions, such as resource supply, are uniform in space. Cyclic interactions are represented by a model with three competitors, resembling the children's game of rock-paper-scissors, whereas the flow field is obtained from a direct numerical simulation of two-dimensional turbulence with hyperviscosity. It is shown that the space-averaged dynamics undergoes bifurcations as the relative strengths of advection and diffusion compared to biological interactions are varied.

  10. Synethesis of cyclic ketal from soybean oil and fatty esters

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this work we have shown a facile and environmentally friendly reaction to form a cyclic ketal out of soybean oil, methyl soyate, methyl linoleate, and methyl oleate. There are many advantages of this reaction. First, the ketal reaction produces a branched fatty acid moiety and is reversible. S...

  11. Analysis and optimization of cyclic methods in orbit computation

    NASA Technical Reports Server (NTRS)

    Pierce, S.

    1973-01-01

    The mathematical analysis and computation of the K=3, order 4; K=4, order 6; and K=5, order 7 cyclic methods and the K=5, order 6 Cowell method and some results of optimizing the 3 backpoint cyclic multistep methods for solving ordinary differential equations are presented. Cyclic methods have the advantage over traditional methods of having higher order for a given number of backpoints while at the same time having more free parameters. After considering several error sources the primary source for the cyclic methods has been isolated. The free parameters for three backpoint methods were used to minimize the effects of some of these error sources. They now yield more accuracy with the same computing time as Cowell's method on selected problems. This work is being extended to the five backpoint methods. The analysis and optimization are more difficult here since the matrices are larger and the dimension of the optimizing space is larger. Indications are that the primary error source can be reduced. This will still leave several parameters free to minimize other sources.

  12. A Cyclic Voltammetry Experiment for the Instrumental Analysis Laboratory.

    ERIC Educational Resources Information Center

    Baldwin, Richard P.; And Others

    1984-01-01

    Background information and procedures are provided for experiments that illustrate the nature of cyclic voltammetry and its application in the characterization of organic electrode processes. The experiments also demonstrate the concepts of electrochemical reversibility and diffusion-controlled mass transfer. (JN)

  13. A Simulation of Counter-Cyclical Intervention: Some Practical Lessons

    ERIC Educational Resources Information Center

    Grawe, Nathan D.; Watts, Michael, Ed.

    2007-01-01

    The author introduces a simulation of counter-cyclical interventions that highlights important issues surrounding the practice of government intervention. The simulation provides experiential insight as to why economists have long debated the degree of persistence exhibited by disequilibrating shocks and connects this debate to discussions about…

  14. 21 CFR 862.1230 - Cyclic AMP test system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Cyclic AMP test system. 862.1230 Section 862.1230 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems §...

  15. 21 CFR 862.1230 - Cyclic AMP test system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Cyclic AMP test system. 862.1230 Section 862.1230 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems §...

  16. 21 CFR 862.1230 - Cyclic AMP test system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Cyclic AMP test system. 862.1230 Section 862.1230 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems §...

  17. 21 CFR 862.1230 - Cyclic AMP test system.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cyclic AMP test system. 862.1230 Section 862.1230 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems §...

  18. 21 CFR 862.1230 - Cyclic AMP test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Cyclic AMP test system. 862.1230 Section 862.1230 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems §...

  19. Revisiting the formation of cyclic clusters in liquid ethanol.

    PubMed

    Balanay, Mannix P; Kim, Dong Hee; Fan, Haiyan

    2016-04-21

    The liquid phase of ethanol in pure and in non-polar solvents was studied at room temperature using Fourier transform infrared (FT-IR) and (1)H nuclear magnetic resonance (NMR) spectroscopies together with theoretical approach. The FT-IR spectra for pure ethanol and solution in cyclohexane at different dilution stages are consistent with (1)H NMR results. The results from both methods were best explained by the results of the density functional theory based on a multimeric model. It is suggested that cyclic trimers and tetramers are dominated in the solution of cyclohexane/hexane with the concentration greater than 0.5M at room temperature. In liquid ethanol, while the primary components at room temperature are cyclic trimers and tetramers, there is a certain amount (∼14%) of open hydroxide group representing the existence of chain like structures in the equilibria. The cyclic cluster model in the liquid and concentrated solution phase (>0.5M) can be used to explain the anomalously lower freezing point of ethanol (159 K) than that of water (273 K) at ambient conditions. In addition, (1)H NMR at various dilution stages reveals the dynamics for the formation of cyclic clusters. PMID:27389215

  20. Characteristics of cyclic AMP transport by marine bacteria

    SciTech Connect

    Ammerman, J.W.; Azam, F.

    1987-12-01

    Uptake and autoradiography experiments with natural populations of marine bacteria, sea water cultures, and cultured isolates showed that the high-affinity cyclic AMP transport system in marine bacteria has stringent structural requirements, is found in a minority of cells in mixed bacterial assemblages, and appears to be related to the culture growth state.

  1. Cyclic Oxidation Testing and Modelling: A NASA Lewis Perspective

    NASA Technical Reports Server (NTRS)

    Smialek, J. L.; Nesbitt, J. A.; Barrett, C. A.; Lowell, C. E.

    2000-01-01

    The Materials Division of the NASA Lewis Research Center has been heavily involved in the cyclic oxidation of high temperature materials for 30 years. Cyclic furnace and burner rig apparati have been developed, refined, and replicated to provide a large scale facility capable of evaluating many materials by a standard technique. Material behavior is characterized by weight change data obtained throughout the test, which has been modelled in a step-wise process of scale growth and spallation. This model and a coupled diffusion model have successfully described cyclic behavior for a number of systems and have provided insights regarding life prediction and variations in the spalling process. Performance ranking and mechanistic studies are discussed primarily for superalloys and coating alloys. Similar cyclic oxidation studies have been performed on steels, intermetallic compounds, thermal barrier coatings, ceramics, and ceramic composites. The most common oxidation test was performed in air at temperatures ranging from 800 deg. to 1600 C, for times up to 10000 h, and for cycle durations of 0.1 to 1000 h. Less controlled, but important, test parameters are the cooling temperature and humidity level. Heating and cooling rates are not likely to affect scale spallation. Broad experience has usually allowed for considerable focus and simplification of these test parameters, while still revealing the principal aspects of material behavior and performance. Extensive testing has been performed to statistically model the compositional effects of experimental alloys and to construct a comprehensive database of complex commercial alloys.

  2. High temperature cyclic oxidation data. Part 1: Turbine alloys

    NASA Technical Reports Server (NTRS)

    Barrett, Charles A.; Garlick, Ralph G.; Lowell, Carl E.

    1989-01-01

    Specific-weight-change-versus-time data and x ray diffraction results are presented derived from high temperature cyclic tests on high temperature, high strength nickel-base gamma/gamma prime and cobalt-base turbine alloys. Each page of data summarizes a complete test on a given alloy sample.

  3. Multigrid and cyclic reduction applied to the Helmholtz equation

    NASA Technical Reports Server (NTRS)

    Brackenridge, Kenneth

    1993-01-01

    We consider the Helmholtz equation with a discontinuous complex parameter and inhomogeneous Dirichlet boundary conditions in a rectangular domain. A variant of the direct method of cyclic reduction (CR) is employed to facilitate the design of improved multigrid (MG) components, resulting in the method of CR-MG. We demonstrate the improved convergence properties of this method.

  4. The Demographic Composition of Cyclical Variations in Employment.

    ERIC Educational Resources Information Center

    Clark, Kim B.; Summers, Lawrence H.

    This paper analyzes the demographic patterns of cyclical swings in the labor market by decomposing movement in employment into changes in unemployment and participation. The focus is on the interrelations among participation, employment and unemployment, with particular emphasis on the participation rate as a prime determinant of the labor market…

  5. Passive cyclic pitch control for horizontal axis wind turbines

    NASA Technical Reports Server (NTRS)

    Bottrell, G. W.

    1981-01-01

    A flexible rotor concept, called the balanced pitch rotor, is described. The system provides passive adjustment of cyclic pitch in response to unbalanced pitching moments across the rotor disk. Various applications are described and performance predictions are made for wind shear and cross wind operating conditions. Comparisons with the teetered hub are made and significant cost savings are predicted.

  6. Crystalline hydrogen-bonded nanocolumns of cyclic thiourea octamers

    SciTech Connect

    Custelcean, Radu; Engle, Nancy L; Bonnesen, Peter V

    2007-01-01

    A bis(thiourea) containing the 1,3-dimethyl-adamantane linker and t-Bu end groups self-assembles in the solid state into crystalline columnar aggregates made of hydrogen-bonded cyclic thiourea octamers with 2 nm diameters.

  7. High-temperature cyclic oxidation data. Part 2: Turbine alloys

    NASA Technical Reports Server (NTRS)

    Barrett, Charles A.; Garlick, Ralph G.

    1989-01-01

    Specific-weight-change-versus-time data and x ray diffraction results are presented derived from high temperature cyclic tests on high temperature, high strength nickel-base gamma/gamma prime and cobalt-base turbine alloys. Each page of data summarizes a complete test on a given alloy sample.

  8. SYNERGISTIC DEGRADATION OF DENTIN BY CYCLIC STRESS AND BUFFER AGITATION

    PubMed Central

    Orrego, Santiago; Romberg, Elaine; Arola, Dwayne

    2015-01-01

    Secondary caries and non-carious lesions develop in regions of stress concentrations and oral fluid movement. The objective of this study was to evaluate the influence of cyclic stress and fluid movement on material loss and subsurface degradation of dentin within an acidic environment. Rectangular specimens of radicular dentin were prepared from caries-free unrestored 3rd molars. Two groups were subjected to cyclic cantilever loading within a lactic acid solution (pH=5) to achieve compressive stresses on the inner (pulpal) or outer sides of the specimens. Two additional groups were evaluated in the same solution, one subjected to movement only (no stress) and the second held stagnant (control: no stress or movement). Exterior material loss profiles and subsurface degradation were quantified on the two sides of the specimens. Results showed that under cyclic stress material loss was significantly greater (p≤0.0005) on the pulpal side than on the outer side and significantly greater (p≤0.05) under compression than tension. However, movement only caused significantly greater material loss (p≤0.0005) than cyclic stress. Subsurface degradation was greatest at the location of highest stress, but was not influenced by stress state or movement. PMID:25637823

  9. Analysis on sheet cyclic plastic deformation using mixed hardening model

    NASA Astrophysics Data System (ADS)

    Li, Qun; Jin, Miao; Yuxin, Zhu

    2013-05-01

    Treating the cyclic deformation problem of sheet flowing through drawbead as the object of the research, using HILL anisotropy yield criterion and mixed hardening model, the cyclic plastic deformation mechanism of sheet was studied, the deformation characteristics of sheet subjected to cyclic loads were revealed, and the influence of Bauschinger effect on stress-strain circulating relationship and the influence of bending neutral layer migration on the stress of sheet's intermediate integral point were analyzed as well. The effectiveness of the model was verified by experiments. The results of analysis were showed that the stress values influenced by Bauschinger effect were different at the yield point of reverse loading and the point of unloading during the cyclic deformation. The stress rate at the yield point of reverse loading and the point of unloading in different loading branches was also different. The stress-strain circulating relationship in different loading branches can be approximately treated as bilinear. The tangent modulus of each loading branch showed a significant downward trend as the times of the reverse loading increased. The tangent modulus calculated by the mixed hardening model after the second loading branch reduced to less than 21% of the first loading tangent modulus. Effected by the neutral layer migration, the stress-strain curve of integral point of sheet's intermediate layer showed alternating transition phenomenon of the tensile stress and compressive stress.

  10. A Geometric Construction of Cyclic Cocycles on Twisted Convolution Algebras

    NASA Astrophysics Data System (ADS)

    Angel, Eitan

    2010-09-01

    In this thesis we give a construction of cyclic cocycles on convolution algebras twisted by gerbes over discrete translation groupoids. In his seminal book, Connes constructs a map from the equivariant cohomology of a manifold carrying the action of a discrete group into the periodic cyclic cohomology of the associated convolution algebra. Furthermore, for proper étale groupoids, J.-L. Tu and P. Xu provide a map between the periodic cyclic cohomology of a gerbe twisted convolution algebra and twisted cohomology groups. Our focus will be the convolution algebra with a product defined by a gerbe over a discrete translation groupoid. When the action is not proper, we cannot construct an invariant connection on the gerbe; therefore to study this algebra, we instead develop simplicial notions related to ideas of J. Dupont to construct a simplicial form representing the Dixmier-Douady class of the gerbe. Then by using a JLO formula we define a morphism from a simplicial complex twisted by this simplicial Dixmier-Douady form to the mixed bicomplex of certain matrix algebras. Finally, we define a morphism from this complex to the mixed bicomplex computing the periodic cyclic cohomology of the twisted convolution algebras.

  11. Methods and systems for the formation of cyclic carbonates

    DOEpatents

    Hatton, Trevor Alan; Jamison, Timothy F; Kozak, Jennifer Aiden; Simeon, Fritz; Wu, Jie

    2014-12-30

    Described herein are inventive methods for synthesis of cyclic carbonates from CO.sub.2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.

  12. Synergistic degradation of dentin by cyclic stress and buffer agitation.

    PubMed

    Orrego, Santiago; Romberg, Elaine; Arola, Dwayne

    2015-04-01

    Secondary caries and non-carious lesions develop in regions of stress concentrations and oral fluid movement. The objective of this study was to evaluate the influence of cyclic stress and fluid movement on material loss and subsurface degradation of dentin within an acidic environment. Rectangular specimens of radicular dentin were prepared from caries-free unrestored 3rd molars. Two groups were subjected to cyclic cantilever loading within a lactic acid solution (pH = 5) to achieve compressive stresses on the inner (pulpal) or outer sides of the specimens. Two additional groups were evaluated in the same solution, one subjected to movement only (no stress) and the second held stagnant (control: no stress or movement). Exterior material loss profiles and subsurface degradation were quantified on the two sides of the specimens. Results showed that under cyclic stress material loss was significantly greater (p ≤ 0.0005) on the pulpal side than on the outer side and significantly greater (p ≤ 0.05) under compression than tension. However, movement only caused significantly greater material loss (p ≤ 0.0005) than cyclic stress. Subsurface degradation was greatest at the location of highest stress, but was not influenced by stress state or movement. PMID:25637823

  13. Finite element forced vibration analysis of rotating cyclic structures

    NASA Technical Reports Server (NTRS)

    Elchuri, V.; Smith, G. C. C.

    1981-01-01

    A capability was added to the general purpose finite element program NASTRAN Level 17.7 to conduct forced vibration analysis of tuned cyclic structures rotating about their axes of symmetry. The effects of Coriolis and centripetal accelerations together with those due to linear acceleration of the axis of rotation were included. The theoretical development of this capability is presented.

  14. Revisiting the formation of cyclic clusters in liquid ethanol

    NASA Astrophysics Data System (ADS)

    Balanay, Mannix P.; Kim, Dong Hee; Fan, Haiyan

    2016-04-01

    The liquid phase of ethanol in pure and in non-polar solvents was studied at room temperature using Fourier transform infrared (FT-IR) and 1H nuclear magnetic resonance (NMR) spectroscopies together with theoretical approach. The FT-IR spectra for pure ethanol and solution in cyclohexane at different dilution stages are consistent with 1H NMR results. The results from both methods were best explained by the results of the density functional theory based on a multimeric model. It is suggested that cyclic trimers and tetramers are dominated in the solution of cyclohexane/hexane with the concentration greater than 0.5M at room temperature. In liquid ethanol, while the primary components at room temperature are cyclic trimers and tetramers, there is a certain amount (˜14%) of open hydroxide group representing the existence of chain like structures in the equilibria. The cyclic cluster model in the liquid and concentrated solution phase (>0.5M) can be used to explain the anomalously lower freezing point of ethanol (159 K) than that of water (273 K) at ambient conditions. In addition, 1H NMR at various dilution stages reveals the dynamics for the formation of cyclic clusters.

  15. Synthesis of glycophostones: cyclic phosphonate analogues of biologically relevant sugars

    PubMed

    Hanessian; Rogel

    2000-05-01

    Analogues of L-fucose, N-acetyl-D-glucosamine, N-acetyl-D-mannosamine, and N-acetyl neuraminic acid in which the anomeric carbon atom was replaced by a phosphonyl group (phostones or cyclic phosphonates) were synthesized by stereocontrolled methods relying on the Abramov reaction. PMID:10808439

  16. Counting Subgroups in a Direct Product of Finite Cyclic Groups

    ERIC Educational Resources Information Center

    Petrillo, Joseph

    2011-01-01

    We calculate the number of subgroups in a direct product of finite cyclic groups by applying the fundamental theorem of finite abelian groups and a well-known structure theorem due to Goursat. We also suggest ways in which the results can be generalized to a direct product of arbitrary finite groups.

  17. Morphodynamics of cyclic steps: a depth-resolved numerical model

    NASA Astrophysics Data System (ADS)

    Vellinga, Age; Cartigny, Matthieu; Eggenhuisen, Joris; Hansen, Ernst

    2015-04-01

    Although the majority of sediment transport is associated to high-discharge events, and such events are prone to Froude-supercritical flow conditions, there are only limited outcrop examples of supercritical-flow deposits. These low numbers of outcrop examples are often explained as being the result of poor preservation potential of upper-stage flow-regime deposits, due to reworking by subcritical flows in the waning stages of these high-discharge events. However, an alternative explanation for this might be that there is not enough knowledge on supercritical-flow deposits to recognise these deposits. This last argument is supported by the fact that numerical and physical experiments in recent years have strongly increased the number of recognised supercritical-flow deposits. Although large progress has been made in the study of the architecture of supercritical-flow deposits, using experimental data and depth-averaged models, scaling issues and measurement difficulties in experiments, and the limitations of depth-averaged models, are impeding further insights in the interaction between the flow and the bed development. Froude-supercritical flows can lead to the formation of bedforms such as antidunes, chutes-and-pools and cyclic steps, the last of which will be focussed of this study. Cyclic steps are described as a series of upstream migrating steps, each step is characterized by a lee-side of the bedform which is eroded by a Froude-supercritical flow and depositional stoss-side of the bedform associated with subcritical flow. The transition between the two flow-regimes is characterized by a hydraulic jump which is located roughly in the trough of a cyclic step bedform. The deposits of cyclic steps can be characterised by backset laminations terminating upstream against the erosional or transportational lee-side of the cyclic step, the backsets can also be eroded by the lee-side of the next upstream-migrating bedform on the downstream end. A novel approach is

  18. Factors associated with early cyclicity in postpartum dairy cows.

    PubMed

    Vercouteren, M M A A; Bittar, J H J; Pinedo, P J; Risco, C A; Santos, J E P; Vieira-Neto, A; Galvão, K N

    2015-01-01

    The objective of this study was to evaluate factors associated with resumption of ovarian cyclicity within 21 days in milk (DIM) in dairy cows. Cows (n=768) from 2 herds in north Florida had their ovaries scanned at 17±3, 21±3, and 24±3 DIM. Cows that had a corpus luteum ≥20mm at 17±3 or at 21±3 DIM or that had a corpus luteum <20mm in 2 consecutive examinations were determined to be cyclic by 21±3 DIM. The following information was collected for up to 14 DIM: calving season, parity, calving problems, metabolic problems, metritis, mastitis, digestive problems, lameness, body weight loss, dry period length, and average daily milk yield. Body condition was scored at 17±3 DIM. Multivariable mixed logistic regression analysis was performed using the GLIMMIX procedure of SAS. Variables with P≤0.2 were considered in each model. Herd was included as a random variable. Three models were constructed: model 1 included all cows, model 2 included only cows from dairy 1 that had daily body weights available, and model 3 included only multiparous cows with a previous dry period length recorded. In model 1, variables associated with greater cyclicity by 21±3 DIM were calving in the summer and fall rather than in the winter or spring, being multiparous rather than primiparous, and not having metabolic or digestive problems. In model 2, variables associated with greater cyclicity by 21±3 DIM were calving in the summer and fall, not having metritis or digestive problems and not losing >28 kg of BW within 14 DIM. In model 3, variables associated with greater cyclicity by 21±3 DIM were absence of metabolic problems and dry period ≤76 d. In summary, cyclicity by 21±3 DIM was negatively associated with calving in winter or spring, primiparity, metritis, metabolic or digestive problems, loss of >28 kg of body weight, and a dry period >76d. Strategies preventing extended dry period length and loss of BW, together with reductions in the incidence of metritis as well as

  19. Cyclic nucleotide phosphodiesterases in heart and vessels: A therapeutic perspective.

    PubMed

    Bobin, Pierre; Belacel-Ouari, Milia; Bedioune, Ibrahim; Zhang, Liang; Leroy, Jérôme; Leblais, Véronique; Fischmeister, Rodolphe; Vandecasteele, Grégoire

    2016-01-01

    Cyclic nucleotide phosphodiesterases (PDEs) degrade the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), thereby regulating multiple aspects of cardiac and vascular muscle functions. This highly diverse class of enzymes encoded by 21 genes encompasses 11 families that are not only responsible for the termination of cyclic nucleotide signalling, but are also involved in the generation of dynamic microdomains of cAMP and cGMP, controlling specific cell functions in response to various neurohormonal stimuli. In the myocardium and vascular smooth muscle, the PDE3 and PDE4 families predominate, degrading cAMP and thereby regulating cardiac excitation-contraction coupling and smooth muscle contractile tone. PDE3 inhibitors are positive inotropes and vasodilators in humans, but their use is limited to acute heart failure and intermittent claudication. PDE5 is particularly important for the degradation of cGMP in vascular smooth muscle, and PDE5 inhibitors are used to treat erectile dysfunction and pulmonary hypertension. There is experimental evidence that these PDEs, as well as other PDE families, including PDE1, PDE2 and PDE9, may play important roles in cardiac diseases, such as hypertrophy and heart failure, as well as several vascular diseases. After a brief presentation of the cyclic nucleotide pathways in cardiac and vascular cells, and the major characteristics of the PDE superfamily, this review will focus on the current use of PDE inhibitors in cardiovascular diseases, and the recent research developments that could lead to better exploitation of the therapeutic potential of these enzymes in the future. PMID:27184830

  20. Cyclic Oxidation Modeling Program Rewritten for MS Windows

    NASA Technical Reports Server (NTRS)

    Smialek, James L.; Auping, Judith V.

    2002-01-01

    Turbine superalloy components are subject to high-temperature oxidation during operation. Protection is often conferred by coatings designed to form slow-growing, adherent oxide scales. Degradation by oxidation is exacerbated by the thermal cycling encountered during normal aircraft operations. Cooling has been identified as the major contributor to stresses in the oxidation scales, and it may often cause some oxide scale spallation with a proportional loss of protective behavior. Overall oxidation resistance is, thus, studied by the weight change behavior of alloy coupons during high-temperature cyclic oxidation in furnace or burner rig tests. The various characteristics of this behavior are crucial in understanding the performance of alloys at high temperatures. This new modeling effort helps in the understanding of the major factors involved in the cyclic oxidation process. Weight change behavior in cyclic oxidation is typified by an initial parabolic weight gain response curve that eventually exhibits a maximum, then transitions into a linear rate of weight loss due to spalling. The overall shape and magnitude of the curve are determined by the parabolic growth rate, kp, the cycle duration, the type of oxide scale, and the regular, repetitive spalling process. This entire process was modeled by a computer program called the Cyclic Oxidation Spalling Program (COSP) previously developed at the NASA Glenn Research Center. Thus, by supplying appropriate oxidation input parameters, one can determine the best fit to the actual data. These parameters describe real behavior and can be used to compare alloys and project cyclic oxidation behavior for longer times or under different cycle frequencies.

  1. Structures and Surface Properties of "Cyclic" Polyoxyethylene Alkyl Ethers: Unusual Behavior of Cyclic Surfactants in Water.

    PubMed

    Hirose, Yuki; Taira, Toshiaki; Sakai, Kenichi; Sakai, Hideki; Endo, Akira; Imura, Tomohiro

    2016-08-23

    The cyclization of amphiphiles has emerged as an attractive strategy for inducing remarkable properties in these materials without changing their chemical composition. In this study, we successfully synthesized three cyclic polyoxyethylene dodecyl ethers (c-POEC12's) with different ring sizes and explored the effects of their topology on their surface and self-assembly properties related to their function, comparing them with those of their linear counterparts (l-POEC12's). The surface activity of the c-POEC12's remained almost constant despite the change in their hydrophobic and hydrophilic balance (HLB) value, while that of the l-POEC12's decreased with an increase in the HLB value as general surfactants. In contrast to the normal micelles seen in the case of the l-POEC12's (3.4-9.7 nm), the cyclization of the POEC12's resulted in the formation of large spherical structures 72.8-256.8 nm in size. It also led to a dramatic decrease of 28 °C in the cloud point temperature. Furthermore, the cyclization of the POEC12's markedly suppressed the rate of protease hydrolysis caused by the surfactants. The initial rate of reduction of a detergent enzyme from Bacillus licheniformis was increased by more than 40% in the case of c-POE600C12 and c-POE1000C12, even though they exhibited surface activities almost equal to or higher than those of their linear counterparts. These results suggest that cyclization induces unusual aqueous behaviors in POEC12, making the surfactant milder with respect to detergent enzymes while ensuring it exhibits increased surface activity. PMID:27462805

  2. Counting surface-kernel epimorphisms from a co-compact Fuchsian group to a cyclic group with motivations from string theory and QFT

    NASA Astrophysics Data System (ADS)

    Bibak, Khodakhast; Kapron, Bruce M.; Srinivasan, Venkatesh

    2016-09-01

    Graphs embedded into surfaces have many important applications, in particular, in combinatorics, geometry, and physics. For example, ribbon graphs and their counting is of great interest in string theory and quantum field theory (QFT). Recently, Koch et al. (2013) [12] gave a refined formula for counting ribbon graphs and discussed its applications to several physics problems. An important factor in this formula is the number of surface-kernel epimorphisms from a co-compact Fuchsian group to a cyclic group. The aim of this paper is to give an explicit and practical formula for the number of such epimorphisms. As a consequence, we obtain an 'equivalent' form of Harvey's famous theorem on the cyclic groups of automorphisms of compact Riemann surfaces. Our main tool is an explicit formula for the number of solutions of restricted linear congruence recently proved by Bibak et al. using properties of Ramanujan sums and of the finite Fourier transform of arithmetic functions.

  3. Quantum Steganography and Quantum Error-Correction

    ERIC Educational Resources Information Center

    Shaw, Bilal A.

    2010-01-01

    Quantum error-correcting codes have been the cornerstone of research in quantum information science (QIS) for more than a decade. Without their conception, quantum computers would be a footnote in the history of science. When researchers embraced the idea that we live in a world where the effects of a noisy environment cannot completely be…

  4. Quantum Hall effect in quantum electrodynamics

    SciTech Connect

    Penin, Alexander A.

    2009-03-15

    We consider the quantum Hall effect in quantum electrodynamics and find a deviation from the quantum-mechanical prediction for the Hall conductivity due to radiative antiscreening of electric charge in an external magnetic field. A weak dependence of the universal von Klitzing constant on the magnetic field strength, which can possibly be observed in a dedicated experiment, is predicted.

  5. Cyclic nucleotide responses and radiation-induced mitotic delay in Physarum polycephalum

    SciTech Connect

    Daniel, J.W.; Oleinick, N.L.

    1984-02-01

    The response of the plasmodial levels of cyclic AMP and cyclic GMP in Physarum polycephalum to several putative phosphodiesterase inhibitors and to ionizing radiation has been measured. Isobutylmethylxanthine (2 mM) induces a rapid transient threefold elevation of cyclic AMP alone, with maximum response in about 10 min and return to the base line in about 30 min. Theophylline (2 mM) induces a rapid, sustained twofold elevation of cyclic GMP only. Caffeine (2mM) and Ro-20-1724 (18 ..mu..M) both elicit a rapid transient rise in cyclic AMP, resembling the isobutylmethylxanthine response, and a slow transient elevation of the cyclic GMP level. Of particular interest is the rapid threefold transient elevation of the cyclic AMP, but not of the cyclic GMP, level by ..gamma.. radiation.

  6. Effects of cadmium on the activities of photosystems of Chlorella pyrenoidosa and the protective role of cyclic electron flow.

    PubMed

    Wang, Shuzhi; Zhang, Daoyong; Pan, Xiangliang

    2013-09-01

    Cadmium (Cd) shows high toxicity to aquatic microalgae. Many studies showed that Cd inhibited activities of photosystem II (PSII) but the effects of heavy metals on photosystem I (PSI) and cyclic electron flow (CEF) were still controversial and unclear. The effects of CdCl2 on the activities of PSI, PSII and CEF in Chlorella pyrenoidosa was measured simultaneously in the present study. In presence of 200μM of Cd, ultrastructure of some cells was strongly modified. Cd exposure led to decrease of the activities of photosynthetic oxygen evolution and respiration. PSII was more sensitive to Cd treatment than PSI. Cd treatment showed significant inhibition on the photochemical quantum yield and electron transport rate of PSII. Cd increased the quantum yield of non-light-induced non-photochemical fluorescence quenching, indicating the damage of PSII. The activity of PSI showed tolerance to Cd treatment with concentration less than 100μM in the experiment. Linear electron flow (LEF) made significant contribution to the photochemical quantum yield of PSI of the untreated cells, but decreased with increasing Cd concentration. The contribution of CEF to the yield of PSI increased with increasing Cd concentration. The activation of CEF after exposure to Cd played an essential role for the protection of PSI. PMID:23726885

  7. Entanglement and Quantum Optics with Quantum Dots

    NASA Astrophysics Data System (ADS)

    Burgers, A. P.; Schaibley, J. R.; Steel, D. G.

    2015-06-01

    Quantum dots (QDs) exhibit many characteristics of simpler two-level (or few level) systems, under optical excitation. This makes atomic coherent optical spectroscopy theory and techniques well suited for understanding the behavior of quantum dots. Furthermore, the combination of the solid state nature of quantum dots and their close approximation to atomic systems makes them an attractive platform for quantum information based technologies. In this chapter, we will discuss recent studies using direct detection of light emitted from a quantum dot to investigate coherence properties and confirm entanglement between the emitted photon and an electron spin qubit confined to the QD.

  8. Quantum algorithms for quantum field theories.

    PubMed

    Jordan, Stephen P; Lee, Keith S M; Preskill, John

    2012-06-01

    Quantum field theory reconciles quantum mechanics and special relativity, and plays a central role in many areas of physics. We developed a quantum algorithm to compute relativistic scattering probabilities in a massive quantum field theory with quartic self-interactions (φ(4) theory) in spacetime of four and fewer dimensions. Its run time is polynomial in the number of particles, their energy, and the desired precision, and applies at both weak and strong coupling. In the strong-coupling and high-precision regimes, our quantum algorithm achieves exponential speedup over the fastest known classical algorithm. PMID:22654052

  9. Approaches to Quantum Gravity

    NASA Astrophysics Data System (ADS)

    Oriti, Daniele

    2009-03-01

    Preface; Part I. Fundamental Ideas and General Formalisms: 1. Unfinished revolution C. Rovelli; 2. The fundamental nature of space and time G. 't Hooft; 3. Does locality fail at intermediate length scales R. Sorkin; 4. Prolegomena to any future quantum gravity J. Stachel; 5. Spacetime symmetries in histories canonical gravity N. Savvidou; 6. Categorical geometry and the mathematical foundations of quantum gravity L. Crane; 7. Emergent relativity O. Dreyer; 8. Asymptotic safety R. Percacci; 9. New directions in background independent quantum gravity F. Markopoulou; Questions and answers; Part II: 10. Gauge/gravity duality G. Horowitz and J. Polchinski; 11. String theory, holography and quantum gravity T. Banks; 12. String field theory W. Taylor; Questions and answers; Part III: 13. Loop Quantum Gravity T. Thiemann; 14. Covariant loop quantum gravity? E. LIvine; 15. The spin foam representation of loop quantum gravity A. Perez; 16. 3-dimensional spin foam quantum gravity L. Freidel; 17. The group field theory approach to quantum gravity D. Oriti; Questions and answers; Part IV. Discrete Quantum Gravity: 18. Quantum gravity: the art of building spacetime J. Ambjørn, J. Jurkiewicz and R. Loll; 19. Quantum Regge calculations R. Williams; 20. Consistent discretizations as a road to quantum gravity R. Gambini and J. Pullin; 21. The causal set approach to quantum gravity J. Henson; Questions and answers; Part V. Effective Models and Quantum Gravity Phenomenology: 22. Quantum gravity phenomenology G. Amelino-Camelia; 23. Quantum gravity and precision tests C. Burgess; 24. Algebraic approach to quantum gravity II: non-commutative spacetime F. Girelli; 25. Doubly special relativity J. Kowalski-Glikman; 26. From quantum reference frames to deformed special relativity F. Girelli; 27. Lorentz invariance violation and its role in quantum gravity phenomenology J. Collins, A. Perez and D. Sudarsky; 28. Generic predictions of quantum theories of gravity L. Smolin; Questions and

  10. Quantum algorithms for quantum field theories

    NASA Astrophysics Data System (ADS)

    Jordan, Stephen

    2015-03-01

    Ever since Feynman's original proposal for quantum computers, one of the primary applications envisioned has been efficient simulation of other quantum systems. In fact, it has been conjectured that quantum computers would be universal simulators, which can simulate all physical systems using computational resources that scale polynomially with the system's number of degrees of freedom. Quantum field theories have posed a challenge in that the set of degrees of freedom is formally infinite. We show how quantum computers, if built, could nevertheless efficiently simulate certain quantum field theories at bounded energy scales. Our algorithm includes a new state preparation technique which we believe may find additional applications in quantum algorithms. Joint work with Keith Lee and John Preskill.

  11. Universal quantum computation by discontinuous quantum walk

    SciTech Connect

    Underwood, Michael S.; Feder, David L.

    2010-10-15

    Quantum walks are the quantum-mechanical analog of random walks, in which a quantum ''walker'' evolves between initial and final states by traversing the edges of a graph, either in discrete steps from node to node or via continuous evolution under the Hamiltonian furnished by the adjacency matrix of the graph. We present a hybrid scheme for universal quantum computation in which a quantum walker takes discrete steps of continuous evolution. This ''discontinuous'' quantum walk employs perfect quantum-state transfer between two nodes of specific subgraphs chosen to implement a universal gate set, thereby ensuring unitary evolution without requiring the introduction of an ancillary coin space. The run time is linear in the number of simulated qubits and gates. The scheme allows multiple runs of the algorithm to be executed almost simultaneously by starting walkers one time step apart.

  12. Secure quantum signatures using insecure quantum channels

    NASA Astrophysics Data System (ADS)

    Amiri, Ryan; Wallden, Petros; Kent, Adrian; Andersson, Erika

    2016-03-01

    Digital signatures are widely used in modern communication to guarantee authenticity and transferability of messages. The security of currently used classical schemes relies on computational assumptions. We present a quantum signature scheme that does not require trusted quantum channels. We prove that it is unconditionally secure against the most general coherent attacks, and show that it requires the transmission of significantly fewer quantum states than previous schemes. We also show that the quantum channel noise threshold for our scheme is less strict than for distilling a secure key using quantum key distribution. This shows that "direct" quantum signature schemes can be preferable to signature schemes relying on secret shared keys generated using quantum key distribution.

  13. Human lower oesophageal sphincter relaxation is associated with raised cyclic nucleotide content.

    PubMed Central

    Barnette, M S; Barone, F C; Fowler, P J; Grous, M; Price, W J; Ormsbee, H S

    1991-01-01

    Increases in cyclic adenosine monophosphate and cyclic guanosine monophosphate content accompany relaxation of isolated strips of opossum and canine lower oesophageal sphincter muscle. The aim of this investigation was to characterise these responses in isolated muscle from the human lower oesophageal sphincter. Electrical stimulation of enteric neurons produced a frequency dependent relaxation of the human lower oesophageal sphincter that was sensitive to tetrodotoxin. Furthermore, as previously shown in the opossum and canine lower oesophageal sphincter, cyclic guanosine monophosphate content was significantly raised in muscle strips frozen during maximum electrical field stimulation whereas cyclic adenosine monophosphate content was unchanged. In addition, sodium nitroprusside (EC50 = 0.1 microM) produced a concentration dependent relaxation of human lower oesophageal sphincter, significantly increased cyclic guanosine monophosphate content, but did not alter cyclic adenosine monophosphate content. Zaprinast (M&B 22948) and SK&F 94120, selective inhibitors of cyclic guanosine monophosphate and cyclic adenosine monophosphate phosphodiesterases, respectively, both relaxed human lower oesophageal sphincter with a potency similar to that seen in the dog or opossum lower oesophageal sphincter. Finally, the 8-bromo analogues of both cyclic adenosine monophosphate (EC50 = 420 microM) and cyclic guanosine monophosphate (EC50 = 100 microM) relaxed the human lower oesophageal sphincter. These studies suggest that in the human, as well as the canine and opossum lower oesophageal sphincter, increases in cyclic nucleotide content are associated with relaxation and increases in cyclic guanosine monophosphate are associated with the relaxation induced by stimulation of enteric neurons. PMID:1846837

  14. 40 CFR 721.10570 - Cyclic amine reaction product with acetophenone and formaldehyde acid salt (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.10570 Cyclic amine reaction product... subject to reporting. (1) The chemical substance identified generically as cyclic amine reaction product... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Cyclic amine reaction product...

  15. 40 CFR 721.10570 - Cyclic amine reaction product with acetophenone and formaldehyde acid salt (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.10570 Cyclic amine reaction product... subject to reporting. (1) The chemical substance identified generically as cyclic amine reaction product... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Cyclic amine reaction product...

  16. A Theoretical Note on Concepts and the Need for Cyclic Concept Maps

    ERIC Educational Resources Information Center

    Safayeni, Frank; Derbentseva, Natalia; Canas, Alberto J.

    2005-01-01

    This article examines concepts and propositions from a theoretical perspective, and establishes the need for and develops an extension to Concept Maps (CMaps), called Cyclic Concept Maps (Cyclic CMaps). Cyclic CMaps are considered to be an appropriate tool for representing knowledge of functional or dynamical relationships between concepts. CMaps,…

  17. Cyclic Material Properties Test to Determine Hardening/Softening Characteristics of HY-80 Steel

    SciTech Connect

    S.C. Hodge; J.M. Minicucci; T.F. Trimble

    2003-04-30

    The Cyclic Material Properties Test was structured to obtain and provide experimental data for determining cyclic hardening/softening characteristics of HY-80 steel. The inelastic strain history data generated by this test program and the resulting cyclic stress-strain curve will be used to enhance material models in the finite element codes used to perform nonlinear elastic-plastic analysis.

  18. Properties of Tangential and Cyclic Polygons: An Application of Circulant Matrices

    ERIC Educational Resources Information Center

    Leung, Allen; Lopez-Real, Francis

    2003-01-01

    In this paper, the properties of tangential and cyclic polygons proposed by Lopez-Real are proved rigorously using the theory of circulant matrices. In particular, the concepts of slippable tangential polygons and conformable cyclic polygons are defined. It is shown that an n-sided tangential (or cyclic) polygon P[subscript n] with n even is…

  19. Diagrammatic quantum mechanics

    NASA Astrophysics Data System (ADS)

    Kauffman, Louis H.; Lomonaco, Samuel J.

    2015-05-01

    This paper explores how diagrams of quantum processes can be used for modeling and for quantum epistemology. The paper is a continuation of the discussion where we began this formulation. Here we give examples of quantum networks that represent unitary transformations by dint of coherence conditions that constitute a new form of non-locality. Local quantum devices interconnected in space can form a global quantum system when appropriate coherence conditions are maintained.

  20. Quantum Discord as a Resource in Quantum Communication

    NASA Astrophysics Data System (ADS)

    Madhok, Vaibhav; Datta, Animesh

    2013-01-01

    As quantum technologies move from the issues of principle to those of practice, it is important to understand the limitations on attaining tangible quantum advantages. In the realm of quantum communication, quantum discord captures the damaging effects of a decoherent environment. This is a consequence of quantum discord quantifying the advantage of quantum coherence in quantum communication. This establishes quantum discord as a resource for quantum communication processes. We discuss this progress, which derives a quantitative relation between the yield of the fully quantum Slepian-Wolf (FQSW) protocol in the presence of noise and the quantum discord of the state involved. The significance of quantum discord in noisy versions of teleportation, super-dense coding, entanglement distillation and quantum state merging are discussed. These results lead to open questions regarding the tradeoff between quantum entanglement and discord in choosing the optimal quantum states for attaining palpable quantum advantages in noisy quantum protocols.

  1. Quantum Discord as a Resource in Quantum Communication

    NASA Astrophysics Data System (ADS)

    Madhok, Vaibhav; Datta, Animesh

    2012-06-01

    As quantum technologies move from the issues of principle to those of practice, it is important to understand the limitations on attaining tangible quantum advantages. In the realm of quantum communication, quantum discord captures the damaging effects of a decoherent environment. This is a consequence of quantum discord quantifying the advantage of quantum coherence in quantum communication. This establishes quantum discord as a resource for quantum communication processes. We discuss this progress, which derives a quantitative relation between the yield of the fully quantum Slepian-Wolf (FQSW) protocol in the presence of noise and the quantum discord of the state involved. The significance of quantum discord in noisy versions of teleportation, super-dense coding, entanglement distillation and quantum state merging are discussed. These results lead to open questions regarding the tradeoff between quantum entanglement and discord in choosing the optimal quantum states for attaining palpable quantum advantages in noisy quantum protocols.

  2. Probabilistic Cloning and Quantum Computation

    NASA Astrophysics Data System (ADS)

    Gao, Ting; Yan, Feng-Li; Wang, Zhi-Xi

    2004-06-01

    We discuss the usefulness of quantum cloning and present examples of quantum computation tasks for which the cloning offers an advantage which cannot be matched by any approach that does not resort to quantum cloning. In these quantum computations, we need to distribute quantum information contained in the states about which we have some partial information. To perform quantum computations, we use a state-dependent probabilistic quantum cloning procedure to distribute quantum information in the middle of a quantum computation.

  3. Quantum interference in thermoelectric molecular junctions: A toy model perspective

    SciTech Connect

    Nozaki, Daijiro E-mail: research@nano.tu-dresden.de; Avdoshenko, Stas M.; Sevinçli, Hâldun; Cuniberti, Gianaurelio

    2014-08-21

    Quantum interference (QI) phenomena between electronic states in molecular circuits offer a new opportunity to design new types of molecular devices such as molecular sensors, interferometers, and thermoelectric devices. Controlling the QI effect is a key challenge for such applications. For the development of single molecular devices employing QI effects, a systematic study of the relationship between electronic structure and the quantum interference is needed. In order to uncover the essential topological requirements for the appearance of QI effects and the relationship between the QI-affected line shape of the transmission spectra and the electronic structures, we consider a homogeneous toy model where all on-site energies are identical and model four types of molecular junctions due to their topological connectivities. We systematically analyze their transmission spectra, density of states, and thermoelectric properties. Even without the degree of freedom for on-site energies an asymmetric Fano peak could be realized in the homogeneous systems with the cyclic configuration. We also calculate the thermoelectric properties of the model systems with and without fluctuation of on-site energies. Even under the fluctuation of the on-site energies, the finite thermoelectrics are preserved for the Fano resonance, thus cyclic configuration is promising for thermoelectric applications. This result also suggests the possibility to detect the cyclic configuration in the homogeneous systems and the presence of the QI features from thermoelectric measurements.

  4. Quantum interference in thermoelectric molecular junctions: A toy model perspective

    NASA Astrophysics Data System (ADS)

    Nozaki, Daijiro; Avdoshenko, Stas M.; Sevinçli, Hâldun; Cuniberti, Gianaurelio

    2014-08-01

    Quantum interference (QI) phenomena between electronic states in molecular circuits offer a new opportunity to design new types of molecular devices such as molecular sensors, interferometers, and thermoelectric devices. Controlling the QI effect is a key challenge for such applications. For the development of single molecular devices employing QI effects, a systematic study of the relationship between electronic structure and the quantum interference is needed. In order to uncover the essential topological requirements for the appearance of QI effects and the relationship between the QI-affected line shape of the transmission spectra and the electronic structures, we consider a homogeneous toy model where all on-site energies are identical and model four types of molecular junctions due to their topological connectivities. We systematically analyze their transmission spectra, density of states, and thermoelectric properties. Even without the degree of freedom for on-site energies an asymmetric Fano peak could be realized in the homogeneous systems with the cyclic configuration. We also calculate the thermoelectric properties of the model systems with and without fluctuation of on-site energies. Even under the fluctuation of the on-site energies, the finite thermoelectrics are preserved for the Fano resonance, thus cyclic configuration is promising for thermoelectric applications. This result also suggests the possibility to detect the cyclic configuration in the homogeneous systems and the presence of the QI features from thermoelectric measurements.

  5. Evaluation of flawed composite structure under static and cyclic loading

    NASA Technical Reports Server (NTRS)

    Porter, T. R.

    1977-01-01

    This paper presents the results of a program investigating the effects of initial defects on the fatigue and fracture response of composite laminates. The structural laminates investigated were a typical angle-ply laminate, a polar/hoop-wound pressure vessel laminate, and a typical engine fan blade laminate. Defects investigated were full- and half-penetration circular holes, full- and half-penetration slits, and countersink holes. Results are presented showing the effects of the defect size and type on the static fracture strength, fatigue performance, and residual static strength. The results of inspection procedures are shown, describing the effect of cyclic and static loadings on damage propagation in composite laminates. The data in this study were used to define proof test levels as a qualification procedure in composite structure subjected to cyclic loading.

  6. Study of quinones reactions with wine nucleophiles by cyclic voltammetry.

    PubMed

    Oliveira, Carla M; Barros, António S; Ferreira, António C S; Silva, Artur M S

    2016-11-15

    Quinones are electrophilic species which can react with various nucleophiles, like wine antioxidants, such as sulfur dioxide or ascorbic acid, thiols, amino acids, and numerous polyphenols. These reactions are very important in wine aging because they mediate oxygen reactions during both production and bottle aging phases. In this work, the major challenge was to determine the interaction between ortho-quinones and wine nucleophiles (amino acids, thiols, and the antioxidants SO2 and ascorbic acid), by cyclic voltammetry. Wine-model solutions with gallic acid, caffeic acid, or (+)-catechin and nucleophilic compounds were used. To understand the effect of nucleophilic addition in wine, a white wine with the same added nucleophiles was also analysed. Cyclic voltammograms were taken with glassy carbon electrode or screen-printed carbon electrodes, respectively, for wine-model and white wines solutions, in the absence and in the presence of nucleophiles. A nucleophilic order profile related to the cathodic current intensity decrease was observed. PMID:27283600

  7. Cyclic di-AMP: another second messenger enters the fray.

    PubMed

    Corrigan, Rebecca M; Gründling, Angelika

    2013-08-01

    Nucleotide signalling molecules contribute to the regulation of cellular pathways in all forms of life. In recent years, the discovery of new signalling molecules in bacteria and archaea, as well as the elucidation of the pathways they regulate, has brought insights into signalling mechanisms not only in bacterial and archaeal cells but also in eukaryotic host cells. Here, we provide an overview of the synthesis and regulation of cyclic di-AMP (c-di-AMP), one of the latest cyclic nucleotide second messengers to be discovered in bacteria. We also discuss the currently known receptor proteins and pathways that are directly or indirectly controlled by c-di-AMP, the domain structure of the enzymes involved in its production and degradation, and the recognition of c-di-AMP by the eukaryotic host. PMID:23812326

  8. Evaluation of Cyclic Behavior of Aircraft Turbine Disk Alloys

    NASA Technical Reports Server (NTRS)

    Shahani, V.; Popp, H. G.

    1978-01-01

    An evaluation of the cyclic behavior of three aircraft engine turbine disk materials was conducted to compare their relative crack initiation and crack propagation resistance. The disk alloys investigated were Inconel 718, hot isostatically pressed and forged powder metallurgy Rene '95, and as-hot-isostatically pressed Rene '95. The objective was to compare the hot isostatically pressed powder metallurgy alloy forms with conventionally processed superalloys as represented by Inconel 718. Cyclic behavior was evaluated at 650 C both under continuously cycling and a fifteen minute tensile hold time cycle to simulate engine conditions. Analysis of the test data were made to evaluate the strain range partitioning and energy exhaustion concepts for predicting hold time effects on low cycle fatigue.

  9. Engine cyclic durability by analysis and material testing

    NASA Technical Reports Server (NTRS)

    Kaufman, A.; Halford, G. R.

    1983-01-01

    The problem of calculating turbine engine component durability is addressed. Nonlinear, finite-element structural analyses, cyclic constitutive behavior models, and an advanced creep-fatigue life prediction method called strainrange partitioning were assessed for their applicability to the solution of durability problems in hot-section components of gas turbine engines. Three different component or subcomponent geometries are examined: a stress concentration in a turbine disk; a louver lip of a half-scale combustor liner; and a squealer tip of a first-stage high-pressure turbine blade. Cyclic structural analyses were performed for all three problems. The computed strain-temperature histories at the critical locations of the combustor linear and turbine blade components were imposed on smooth specimens in uniaxial, strain-controlled, thermomechanical fatigue tests of evaluate the structural and life analysis methods.

  10. Application of cyclic fluorocarbon/argon discharges to device patterning

    DOE PAGESBeta

    Metzler, Dominik; Uppiredi, Kishore; Bruce, Robert L.; Miyazoe, Hiroyuki; Zhu, Yu; Price, William; Sikorski, Ed S.; Li, Chen; Engelmann, Sebastian U.; Joseph, Eric A.; et al

    2015-11-13

    With increasing demands on device patterning to achieve smaller critical dimensions and pitches for the 5nm node and beyond, the need for atomic layer etching (ALE) is steadily increasing. In this study, a cyclic fluorocarbon/Ar plasma is successfully used for ALE patterning in a manufacturing scale reactor. Self-limited etching of silicon oxide is observed. The impact of various process parameters on the etch performance is established. The substrate temperature has been shown to play an especially significant role, with lower temperatures leading to higher selectivity and lower etch rates, but worse pattern fidelity. The cyclic ALE approach established with thismore » work is shown to have great potential for small scale device patterning, showing self-limited etching, improved uniformity and resist mask performance.« less

  11. On the modeling of nonproportional cyclic plasticity of Waspaloy

    SciTech Connect

    Abdul-Latif, A.; Clavel, M.; Ferney, V.; Saanouni, K. )

    1994-01-01

    The isotropic hardening is known to play an effective role in the overhardening of materials under nonproportional cyclic loading. However, the behavior of the two states of Waspaloy (namely overaged and underaged states) under these loading conditions, shows that the kinematic hardening has also a considerable role in the overhardening. Experimental tests were carried out on these two states under various proportional and nonproportional cyclic loading conditions at room temperature. The effect of loading paths on micro-mechanisms of deformation was studied. From a microstructural point of view, it was shown that the deformation modes (quantitatively and qualitatively) depends on the loading path and the heat treatment. A constitutive model is proposed to describe the effect of overhardening, under the nonproportional loading conditions, on the kinematic hardening. The predicted response are in good agreement with experimental results.

  12. Cyclic Peptides Made by Linking Synthetic and Genetically Encoded Fragments.

    PubMed

    Palei, Shubhendu; Mootz, Henning D

    2016-03-01

    Cyclic peptides can be highly valuable as bioactive molecules, both for biomedical applications and in basic research. We introduce a new fragment-based approach to access cyclic peptide structures in which one fragment is of synthetic origin and the other is genetically encoded. The synthetic peptide, which can contain one or more non-proteinogenic building blocks, is coupled to the recombinantly expressed peptide through two bonds, one formed by protein trans-splicing with a split intein and the other by oxime ligation. Semisynthetic macrocycles were obtained with high efficiency for various sequences and ring sizes; they can be prepared in quantities sufficient for initial bioactivity tests. We also prepared lipidated and d-amino-acid-containing peptides that were inspired by the peptide antibiotic daptomycin. Such structures are not accessible by other methods that harness the power of simple genetic diversification in the DNA-encoded part of the peptide. PMID:26691013

  13. Strain rate change transients during cyclic deformation of copper

    SciTech Connect

    Kaschner, G.C.; Gibeling, J.C.

    1996-12-15

    In the present study, the authors have undertaken to apply the strain rate change method to mechanically probe the mechanisms of cyclic deformation in copper. The goals of this work were twofold: to carefully explore differences in results obtained under conventional displacement control with those recorded under plastic strain control and to apply the formalism for monotonic deformation described above to cyclic deformation. To achieve these goals, it has been necessary to utilize computed-variable servo-hydraulic control to develop a new test technique incorporating strain rate change tests performed during low cycle fatigue. Plastic strain is used as the control variable to ensure a constant plastic strain rate between pre-determined plastic strain limits.

  14. Application of cyclic fluorocarbon/argon discharges to device patterning

    SciTech Connect

    Metzler, Dominik; Uppiredi, Kishore; Bruce, Robert L.; Miyazoe, Hiroyuki; Zhu, Yu; Price, William; Sikorski, Ed S.; Li, Chen; Engelmann, Sebastian U.; Joseph, Eric A.; Oehrlein, Gottlieb S.

    2015-11-13

    With increasing demands on device patterning to achieve smaller critical dimensions and pitches for the 5nm node and beyond, the need for atomic layer etching (ALE) is steadily increasing. In this study, a cyclic fluorocarbon/Ar plasma is successfully used for ALE patterning in a manufacturing scale reactor. Self-limited etching of silicon oxide is observed. The impact of various process parameters on the etch performance is established. The substrate temperature has been shown to play an especially significant role, with lower temperatures leading to higher selectivity and lower etch rates, but worse pattern fidelity. The cyclic ALE approach established with this work is shown to have great potential for small scale device patterning, showing self-limited etching, improved uniformity and resist mask performance.

  15. Cyclic creep analysis from elastic finite-element solutions

    NASA Technical Reports Server (NTRS)

    Kaufman, A.; Hwang, S. Y.

    1986-01-01

    A uniaxial approach was developed for calculating cyclic creep and stress relaxation at the critical location of a structure subjected to cyclic thermomechanical loading. This approach was incorporated into a simplified analytical procedure for predicting the stress-strain history at a crack initiation site for life prediction purposes. An elastic finite-element solution for the problem was used as input for the simplified procedure. The creep analysis includes a self-adaptive time incrementing scheme. Cumulative creep is the sum of the initial creep, the recovery from the stress relaxation and the incremental creep. The simplified analysis was exercised for four cases involving a benchmark notched plate problem. Comparisons were made with elastic-plastic-creep solutions for these cases using the MARC nonlinear finite-element computer code.

  16. NASTRAN forced vibration analysis of rotating cyclic structures

    NASA Technical Reports Server (NTRS)

    Elchuri, V.; Smith, G. C. C.; Gallo, A. M.

    1983-01-01

    Theoretical aspects of a new capability, developed and added to the general purpose finite element program NASTRAN Level 17.7, to conduct forced vibration analysis of turned cyclic structures rotating about their axis of symmetry, are presented. The effects of Coriolis and centripetal accelerations as well as those due to the translational acceleration of the axis of rotation, are included. The equations of motion are first derived for an arbitrary grid point of the cyclic sector finite element model and then extended for the complete model. The equations are solved by four principal steps: (1) transformation of applied loads at frequency-dependent circumferential harmonic components; (2) application of circumferential harmonic-dependent intersegment compatibility constraints; (3) solution of frequency-dependent circumferential harmonic components of displacements; and (4) recovery of frequency-dependent response in various segments of the total structure. Five interrelated examples are presented to illustrate the various features of the development.

  17. Cyclic silylated onium ions of group 15 elements.

    PubMed

    Reissmann, Matti; Schäfer, André; Panisch, Robin; Schmidtmann, Marc; Bolte, Michael; Müller, Thomas

    2015-03-01

    Five- and six-membered cyclic silylated onium ions of group 15 elements I were synthesized by intramolecular cyclization of transient silylium ions II. Silylium ions II were prepared by the hydride transfer reaction from silanes III using trityl cation as hydride acceptor. It was found that smaller ring systems could not be obtained by this approach. In these cases tritylphosphonium ions IV were isolated instead. Cations I and IV were isolated in the form of their tetrakispentafluorphenyl borates and characterized by multinuclear NMR spectroscopy and, in two cases, by X-ray diffraction analysis. Cyclic onium ions I showed no reactivity similar to that of isoelectronic intramolecular borane/phosphane frustrated Lewis pairs (FLPs). The results of DFT computations at the M05-2X level suggest that the strength of the newly formed Si-E linkage is the major reason for inertness of I[B(C6F5)4] versus molecular hydrogen. PMID:25664605

  18. Cyclic Plasticity under Shock Loading in an HCP Metal

    SciTech Connect

    Prime, Michael B.; Hunter, Abigail; Canfield, Thomas R.; Adams, Chris D.

    2012-06-08

    Plate impact experiments with pressures from 2 to 20 GPa, including one shock-partial release-reshock experiment, were performed on vacuum hot-pressed S-200F Beryllium. This hexagonal close-packed (HCP) metal shows significant plasticity effects in such conditions. The experiments were modeled in a Lagrangian hydrocode using an experimentally calibrated Preston-Tonks-Wallace (PTW) constitutive model. By using the shock data to constrain a high rate portion of PTW, the model was able to generally match plasticity effects on the measured wave profile (surface velocity) during the shock loading, but not unloading. A backstress-based cyclic plasticity model to capture the quasi-elastic release (Bauschinger-type effect) was explored in order to match the unloading and reloading portions of the measured wave profiles. A comparison is made with other approaches in the literature to capture the cyclic plasticity in shock conditions.

  19. Medicinal chemistry of fluorinated cyclic and acyclic nucleoside phosphonates.

    PubMed

    Baszczyňski, Ondřej; Janeba, Zlatko

    2013-11-01

    The fluorine atom plays an important role in medicinal chemistry because fluorine substitution has a strong impact on the physical, chemical, and biological properties of bioactive compounds. Such fluorine modifications have also been extensively studied among the pharmaceutically important class of nucleoside phosphonates, nucleotide analogues in which the phosphate group is replaced by the enzymatically and chemically stable phosphonate moiety. The fluorinated nucleoside phosphonates abound with antiviral, antiparasitic, and anticancer properties because they are able to act as inhibitors of important enzymes of nucleoside/nucleotide metabolism. In this paper, we review the biological properties of cyclic and acyclic nucleoside phosphonates modified by the attachment of one or more fluorine atoms to various parts of the molecule, namely to nucleobases, alkylphosphonate groups, cyclic or acyclic linkers, or to prodrug moieties. PMID:23893552

  20. Cyclic variations of the period and luminosity of SV Camelopardalis

    NASA Astrophysics Data System (ADS)

    Manzoori, D.

    2016-07-01

    New standardized V-band light curves (LCs) for the eclipsing binary SV Cam have been modeled using the PHOEBE program (v. 0.31a). Absolute parameters of the stellar components were then determined, enabling them to be positioned on the mass-radius diagram. Analysis of eclipse minima timing data (O-C diagrams) indicated two cyclic periods of 48.0 and 23.3 yr. These cyclic variations of the orbital period are interpreted in terms of motion of a third body around the system and magnetic activity cycle modulating the orbital period of SV Cam via the Applegate (1992) mechanism. The use of the Applegate model for SV Cam has been checked by examining the long term brightness variation and calculating some important parameters of this system. The results of these calculations favor the modulation of the orbital period by the Applegate mechanism.

  1. Matrix cracking in laminated composites under monotonic and cyclic loadings

    NASA Technical Reports Server (NTRS)

    Allen, David H.; Lee, Jong-Won

    1991-01-01

    An analytical model based on the internal state variable (ISV) concept and the strain energy method is proposed for characterizing the monotonic and cyclic response of laminated composites containing matrix cracks. A modified constitution is formulated for angle-ply laminates under general in-plane mechanical loading and constant temperature change. A monotonic matrix cracking criterion is developed for predicting the crack density in cross-ply laminates as a function of the applied laminate axial stress. An initial formulation for a cyclic matrix cracking criterion for cross-ply laminates is also discussed. For the monotonic loading case, a number of experimental data and well-known models are compared with the present study for validating the practical applicability of the ISV approach.

  2. A kinematic model for Bayesian tracking of cyclic human motion

    NASA Astrophysics Data System (ADS)

    Greif, Thomas; Lienhart, Rainer

    2010-01-01

    We introduce a two-dimensional kinematic model for cyclic motions of humans, which is suitable for the use as temporal prior in any Bayesian tracking framework. This human motion model is solely based on simple kinematic properties: the joint accelerations. Distributions of joint accelerations subject to the cycle progress are learned from training data. We present results obtained by applying the introduced model to the cyclic motion of backstroke swimming in a Kalman filter framework that represents the posterior distribution by a Gaussian. We experimentally evaluate the sensitivity of the motion model with respect to the frequency and noise level of assumed appearance-based pose measurements by simulating various fidelities of the pose measurements using ground truth data.

  3. Quantum Cosmology

    NASA Astrophysics Data System (ADS)

    Bojowald, Martin

    The universe, ultimately, is to be described by quantum theory. Quantum aspects of all there is, including space and time, may not be significant for many purposes, but are crucial for some. And so a quantum description of cosmology is required for a complete and consistent worldview. At any rate, even if we were not directly interested in regimes where quantum cosmology plays a role, a complete physical description could not stop at a stage before the whole universe is reached. Quantum theory is essential in the microphysics of particles, atoms, molecules, solids, white dwarfs and neutron stars. Why should one expect this ladder of scales to end at a certain size? If regimes are sufficiently violent and energetic, quantum effects are non-negligible even on scales of the whole cosmos; this is realized at least once in the history of the universe: at the big bang where the classical theory of general relativity would make energy densities diverge. 1.Lachieze-Rey, M., Luminet, J.P.: Phys. Rept. 254,135 (1995), gr-qc/9605010 2.BSDeWitt1967Phys. Rev.160511131967PhRv..160.1113D0158.4650410.1103/PhysRev.160.1113DeWitt, B.S.: Phys. Rev. 160(5), 1113 (1967) 3.Wiltshire, D.L.: In: Robson B., Visvanathan N., Woolcock W.S. (eds.) Cosmology: The Physics of the Universe, pp. 473-531. World Scientific, Singapore (1996

  4. Apoptotic Cell Localization in Preantral and Antral Follicles in Relation to Non-cyclic and Cyclic Gilts.

    PubMed

    Phoophitphong, D; Srisuwatanasagul, S; Koonjaenak, S; Tummaruk, P

    2016-06-01

    The objective of this study was to determine apoptotic cell localization in preantral and antral follicles of porcine ovaries. Additionally, the proportion of cells undergoing apoptosis was also compared between delayed puberty gilts and normal cyclic gilts. Ovarian tissues were obtained from 34 culled gilts with age and weight of 270.1 ± 3.9 days and 143.8 ± 2.4 kg, respectively. The gilts were classified according to their ovarian appearance as 'non-cyclic' (n = 7) and 'cyclic' (n = 27) gilts. The terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) assay was used to determine apoptotic cell expression in different compartments of the ovarian tissue sections. All apparent preantral (n = 110) and antral (n = 262) follicles were evaluated using image analysis software. It was found that apoptotic cells were expressed in both granulosa (22.2%) and theca cell layers (21.3%) of the follicles in the porcine ovaries. The proportion of apoptotic cells in the granulosa layer in the follicles was positively correlated with that in the theca layer (r = 0.90, p < 0.001). Apoptosis did not differ significantly between preantral and antral follicles in either granulosa (27.8% and 26.4%, p > 0.05) or theca cell layers (28.6% and 26.5%, p > 0.05). The proportion of apoptotic cells in non-cyclic gilts was higher than cyclic gilts in both granulosa (31.7% and 22.6%, p < 0.001) and theca cell layers (34.8% and 20.2%, p < 0.001). This study indicated that apoptosis of the granulosa and theca cell layers in the follicles was more pronounced in the ovarian tissue of delayed puberty gilts than cyclic gilts. This implied that apoptosis could be used as a biologic marker for follicular development/function and also that apoptosis was significantly associated with anoestrus or delayed puberty in gilts, commonly observed in tropical climates. PMID:27080320

  5. Isolation of a Cyclic (Alkyl)(amino)germylene.

    PubMed

    Wang, Liliang; Lim, Yi Shan; Li, Yongxin; Ganguly, Rakesh; Kinjo, Rei

    2016-01-01

    A 1,4-addition of a dichlorogermylene dioxane complex with α,β-unsaturated imine 1 gave a dichlorogermane derivative 2 bearing a GeC₃N five-membered ring skeleton. By reducing 2 with KC₈, cyclic (alkyl)(amino)germylene 3 was synthesized and fully characterized. Germylene 3 readily reacted with TEMPO, N₂O and S₈, producing the 1:2 adduct 4, the oxo-bridged dimer 5 and the sulfido-bridged dimer 6, respectively. PMID:27483223

  6. Analysis Of The Interface Behavior Under Cyclic Loading

    SciTech Connect

    Mortara, Giuseppe

    2008-07-08

    This paper analyses the frictional behavior between soil and structures under cyclic loading conditions. In particular, the attention is focused on the stress degradation occurring in sand-metal interface tests and on the relevant parameters playing a role in such kind of tests. Also, the paper reports the analysis of the experimental data from the constitutive point of view with a two-surface elastoplastic model.

  7. Cyclic nucleotides in tissues during long-term hypokinesia

    NASA Technical Reports Server (NTRS)

    Makeyeva, V. F.; Komolova, G. S.; Yegorov, I. A.; Serova, L. V.; Chelnaya, N. A.

    1981-01-01

    Male Wistar rates were kept hypokinetic by placing them in small containers for 22 days. Blood plasma cAMP content was subsequently found increased, and cGMP content decreased, in the experimental animals. Liver and thymus cAMP content was similar in the control and experimental animals. There was a 20 and 38% decrease of cAMP content in the kidneys and spleen, respectively. Hypokinesia's reduction of cyclic nucleotides seems to inhibit RNA and protein synthesis.

  8. Enhanced catalyst stability for cyclic co methanation operations

    DOEpatents

    Risch, Alan P.; Rabo, Jule A.

    1983-01-01

    Carbon monoxide-containing gas streams are passed over a catalyst to deposit a surface layer of active surface carbon thereon essentially without the formation of inactive coke. The active carbon is thereafter reacted with steam or hydrogen to form methane. Enhanced catalyst stability for long term, cyclic operation is obtained by the incorporation of an alkali or alkaline earth dopant in a silica binding agent added to the catalyst-support additive composition.

  9. Forced vibration analysis of rotating cyclic structures in NASTRAN

    NASA Technical Reports Server (NTRS)

    Elchuri, V.; Gallo, A. M.; Skalski, S. C.

    1981-01-01

    A new capability was added to the general purpose finite element program NASTRAN Level 17.7 to conduct forced vibration analysis of tuned cyclic structures rotating about their axis of symmetry. The effects of Coriolis and centripetal accelerations together with those due to linear acceleration of the axis of rotation were included. The theoretical, user's, programmer's and demonstration manuals for this new capability are presented.

  10. Area, Diagonals, and Circumcircle of a Cyclic Quadrilateral

    ERIC Educational Resources Information Center

    Ayoub, Ayoub B.

    2006-01-01

    In the seventh century, around 650 A.D., the Indian mathematician Brahmagupta came up with a remarkable formula expressing the area E of a cyclic quadrilateral in terms of the lengths a, b, c, d of its sides. In his formula E = [square root](s-a)(s-b)(s-c)(s-d), s stands for the semiperimeter 1/2(a+b+c+d). The fact that Brahmagupta's formula is…

  11. Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity.

    PubMed

    Kaneda, Toshio; Yoshida, Haruka; Nakajima, Yuki; Toishi, Minako; Nugroho, Alfarius Eko; Morita, Hiroshi

    2016-04-01

    Flaxseed (Linum usitatissimum seed) is widely used in food and natural health products. In our search for osteoclast differentiation inhibitors, some cyclic peptides isolated from flaxseed, known as the cyclolinopeptides, were discovered to have osteoclast differentiation inhibition activity. The osteoclast differentiation inhibition activity of cyclolinopeptides A-I (1-9) and their related derivatives (10-14) are described herein. Cyclolinopeptides F, H and I (6, 8 and 9), in particular, showed potent osteoclast differentiation inhibition activity. PMID:26923696

  12. Higher Genus Abelian Functions Associated with Cyclic Trigonal Curves

    NASA Astrophysics Data System (ADS)

    England, Matthew

    2010-03-01

    We develop the theory of Abelian functions associated with cyclic trigonal curves by considering two new cases. We investigate curves of genus six and seven and consider whether it is the trigonal nature or the genus which dictates certain areas of the theory. We present solutions to the Jacobi inversion problem, sets of relations between the Abelian function, links to the Boussinesq equation and a new addition formula.

  13. Nicral ternary alloy having improved cyclic oxidation resistance

    NASA Technical Reports Server (NTRS)

    Barrett, C. A.; Lowell, C. E.; Khan, A. S.

    1982-01-01

    NiCrAl alloys are improved by the addition of zirconium. These alloys are in the Beta or gamma/gamma' + Beta region of the ternary system. Zirconium is added in a very low amount between 0.06 and 0.20 weight percent. There is a narrow optimum zirconium level at the low value of 0.13 weight percent. Maximum resistance to cyclic oxidation is achieved when the zirconium addition is at the optimum value.

  14. Quantum optics, cavity QED, and quantum optomechanics

    NASA Astrophysics Data System (ADS)

    Meystre, Pierre

    2013-05-01

    Quantum optomechanics provides a universal tool to achieve the quantum control of mechanical motion. It does that in devices spanning a vast range of parameters, with mechanical frequencies from a few Hertz to GHz, and with masses from 10-20 g to several kilos. Its underlying ideas can be traced back to the study of gravitational wave antennas, quantum optics, cavity QED and laser cooling which, when combined with the recent availability of advanced micromechanical and nanomechanical devices, opens a path to the realization of macroscopic mechanical systems that operate deep in the quantum regime. At the fundamental level this development paves the way to experiments that will lead to a more profound understanding of quantum mechanics; and from the point of view of applications, quantum optomechanical techniques will provide motion and force sensing near the fundamental limit imposed by quantum mechanics (quantum metrology) and significantly expand the toolbox of quantum information science. After a brief summary of key historical developments, the talk will give a broad overview of the current state of the art of quantum optomechanics, and comment on future prospects both in applied and in fundamental science. Work supported by NSF, ARO and the DARPA QuASAR and ORCHID programs.

  15. Cyclic Dinucleotide-Controlled Regulatory Pathways in Streptomyces Species

    PubMed Central

    2015-01-01

    The cyclic dinucleotides cyclic 3′,5′-diguanylate (c-di-GMP) and cyclic 3′,5′-diadenylate (c-di-AMP) have emerged as key components of bacterial signal transduction networks. These closely related second messengers follow the classical general principles of nucleotide signaling by integrating diverse signals into regulatory pathways that control cellular responses to changing environments. They impact distinct cellular processes, with c-di-GMP having an established role in promoting bacterial adhesion and inhibiting motility and c-di-AMP being involved in cell wall metabolism, potassium homeostasis, and DNA repair. The involvement of c-dinucleotides in the physiology of the filamentous, nonmotile streptomycetes remained obscure until recent discoveries showed that c-di-GMP controls the activity of the developmental master regulator BldD and that c-di-AMP determines the level of the resuscitation-promoting factor A(RpfA) cell wall-remodelling enzyme. Here, I summarize our current knowledge of c-dinucleotide signaling in Streptomyces species and highlight the important roles of c-di-GMP and c-di-AMP in the biology of these antibiotic-producing, multicellular bacteria. PMID:26216850

  16. Modeling of viscoplastic cyclic loading behavior of polymers

    NASA Astrophysics Data System (ADS)

    Spathis, G.; Kontou, E.

    2015-08-01

    A new theoretical approach, analyzed in previous works, is employed for the description of the nonlinear viscoelastic/viscoplastic response of high density polyethylene under tensile cyclic loading, experimentally studied elsewhere. The proposed analysis, developed for a 3-D problem, is applied for a uniaxial cyclic deformation, in a strain-controlled program, where tensile loading up to maximum strain is followed by unloading to zero stress. This procedure is repeated for ten cycles. The same model is also applied for the simulation of a stress-controlled program, where cyclic loading takes place between a and engineering stress. The hysteresis loops of both programs could be adequately captured, with a number of model parameters, related to both, nonlinear viscoelasticity and viscoplasticity. The simulated ratcheting strain as well as its evolution with number of cycles is a very good approximation of the experimental one. A systematic study of the values of the adjustable parameters has been performed in order to monitor the effect of every specific internal variable, responsible for either the nonlinear viscoelastic or viscoplastic path in the simulations. It was found that in the proposed analysis a rather low number of model parameters are required, compared to the works existing in the literature.

  17. Continuous cellulosic bioethanol fermentation by cyclic fed-batch cocultivation.

    PubMed

    Jiang, He-Long; He, Qiang; He, Zhili; Hemme, Christopher L; Wu, Liyou; Zhou, Jizhong

    2013-03-01

    Cocultivation of cellulolytic and saccharolytic microbial populations is a promising strategy to improve bioethanol production from the fermentation of recalcitrant cellulosic materials. Earlier studies have demonstrated the effectiveness of cocultivation in enhancing ethanolic fermentation of cellulose in batch fermentation. To further enhance process efficiency, a semicontinuous cyclic fed-batch fermentor configuration was evaluated for its potential in enhancing the efficiency of cellulose fermentation using cocultivation. Cocultures of cellulolytic Clostridium thermocellum LQRI and saccharolytic Thermoanaerobacter pseudethanolicus strain X514 were tested in the semicontinuous fermentor as a model system. Initial cellulose concentration and pH were identified as the key process parameters controlling cellulose fermentation performance in the fixed-volume cyclic fed-batch coculture system. At an initial cellulose concentration of 40 g liter(-1), the concentration of ethanol produced with pH control was 4.5-fold higher than that without pH control. It was also found that efficient cellulosic bioethanol production by cocultivation was sustained in the semicontinuous configuration, with bioethanol production reaching 474 mM in 96 h with an initial cellulose concentration of 80 g liter(-1) and pH controlled at 6.5 to 6.8. These results suggested the advantages of the cyclic fed-batch process for cellulosic bioethanol fermentation by the cocultures. PMID:23275517

  18. NASTRAN forced vibration analysis of rotating cyclic structures

    NASA Technical Reports Server (NTRS)

    Elchuri, V.; Smith, G. C. C.; Gallo, A. M.

    1983-01-01

    Theoretical aspects of a new capability developed and implemented in NASTRAN level 17.7 to analyze forced vibration of a cyclic structure rotating about its axis of symmetry are presented. Fans, propellers, and bladed shrouded discs of turbomachines are some examples of such structures. The capability includes the effects of Coriolis and centripetal accelerations on the rotating structure which can be loaded with: (1) directly applied loads moving with the structure and (2) inertial loas due to the translational acceleration of the axis of rotation (''base' acceleration). Steady-state sinusoidal or general periodic loads are specified to represent: (1) the physical loads on various segments of the complete structure, or (2) the circumferential harmonic components of the loads in (1). The cyclic symmetry feature of the rotating structure is used in deriving and solving the equations of forced motion. Consequently, only one of the cyclic sectors is modelled and analyzed using finite elements, yielding substantial savings in the analysis cost. Results, however, are obtained for the entire structure. A tuned twelve bladed disc example is used to demonstrate the various features of the capability.

  19. 32P-postlabelling methods for cyclic DNA adducts.

    PubMed

    Watson, W P; Crane, A E; Steiner, S

    1993-01-01

    32P-Postlabelling procedures coupled with HPLC have been developed to detect and measure a range of cyclic DNA adducts formed by bifunctional genotoxic agents. The methods are based on reverse-phase HPLC, particularly column-switching HPLC, to enrich adduct 3'-monophosphates before labelling. Following 3'-dephosphorylation of the 3'5'-[5'-32P]bisphosphates with nuclease P1, the resulting 5'-[32P]monophosphate adducts are resolved, identified and characterized by co-chromatography with synthetic reference standards. The procedures have been applied to a number of cyclic adducts including those formed by chloroacetaldehyde, glycidaldehyde and malonaldehyde. In general, labelling efficiencies measured as chromatographed 5'-[32P]monophosphates were in the range 30-40%. However, the values for the malonaldehyde deoxyguanosine adduct were much lower. The techniques have been applied to studies on the formation of DNA adducts in the skin of male C3H mice treated cutaneously with glycidaldehyde. The HPLC-32P-postlabelling analysis of epidermal DNA hydrolysates indicated that a single major cyclic adduct was formed by reaction with deoxyadenosine residues in mouse skin DNA. The adduct was identified as a hydroxymethyl ethenodeoxyadenosine adduct by comparison with a synthetic standard. This adduct was highly fluorescent and it was possible to make quantitative comparisons of the amounts of adduct determined by either HPLC-32P-postlabelling or HPLC-fluorescence detection. PMID:8225493

  20. Modeling Step-Strain Relaxation and Cyclic Deformations of Elastomers

    NASA Technical Reports Server (NTRS)

    Johnson, A.R.; Mead, J. L.

    2000-01-01

    Data for step-strain relaxation and cyclic compressive deformations of highly viscous short elastomer cylinders are modeled using a large strain rubber viscoelastic constitutive theory with a rate-independent friction stress term added. In the tests, both small and large amplitude cyclic compressive strains, in the range of 1% to 10%, were superimposed on steady state compressed strains, in the range of 5% to 20%, for frequencies of 1 and 10 Hz. The elastomer cylinders were conditioned prior to each test to soften them. The constants in the viscoclastic-friction constitutive theory are determined by employing a nonlinear least-squares method to fit the analytical stresses for a Maxwell model, which includes friction, to measured relaxation stresses obtained from a 20% step-strain compression test. The simulation of the relaxation data with the nonlinear model is successful at compressive strains of 5%, 10%, 15%, and 20%. Simulations of hysteresis stresses for enforced cyclic compressive strains of 20% +/- 5% are made with the model calibrated by the relaxation data. The predicted hysteresis stresses are lower than the measured stresses.

  1. Cyclic sediment deposition within Amazon deep-sea fan

    SciTech Connect

    Manley, P.L.; Flood, R.D.

    1988-08-01

    The Upper and middle Amazon Fan has grown in a cyclic fashion. An individual deposition cycle consists of (1) a widespread basal, acoustically transparent seismic unit (interpreted as debris-flow deposits) that fills and levels preexisting topographic lows, and (2) a levee complex built of overlapping channel-levee systems. Two and possibly three cycles have been identified within the Amazon Fan. The levee complex beneath one debris flow originated from a different submarine canyon than did the levee complex above the debris flow, suggesting that these levee complexes formed during different sea level lowstands. Calculations based on present sediment discharge of the Amazon River suggest that an entire levee complex can form within the time span of a single glacial stage, such as the Wisconsin; however, the levee complex probably could not have formed during the relatively short time interval when sea level rose rapidly at the end of a glacial stage. The basal seismic units (debris-flow deposits) may have been deposited at any time during sea level fluctuations. Although seismic evidence suggests that this cyclic sedimentation pattern may be related to glacio-eustatic sea level variations, cyclic fan growth may be attributed to other processes as well. For example, a bottom-simulating reflector (BSR) observed within the upper fan appears to be a gas hydrate. Migration of the hydrate phase boundary during sea level fluctuations and diapiric activity may be mechanisms for initiating widespread debris flows. 10 figs.

  2. Cyclic Compressive Loading Facilitates Recovery after Eccentric Exercise

    PubMed Central

    BUTTERFIELD, TIMOTHY A.; ZHAO, YI; AGARWAL, SUDHA; HAQ, FURQAN; BEST, THOMAS M.

    2016-01-01

    Purpose To assess the biologic basis of massage therapies, we developed an experimental approach to mimic Swedish massage and evaluate this approach on recovery from eccentric exercise-induced muscle damage using a well-controlled animal model. Methods Tibialis anterior muscles of six New Zealand White rabbits were subjected to one bout of damaging, eccentric contractions. One muscle was immediately subjected to cyclic compressive loads, and the contralateral served as the exercised control. Results We found that commencing 30 min of cyclic compressive loading to the muscle, immediately after a bout of eccentric exercise, facilitated recovery of function and attenuated leukocyte infiltration. In addition, fiber necrosis and wet weight of the tissue were also reduced by compressive loading. Conclusion We conclude that subjecting muscle to compressive loads immediately after exercise leads to an enhanced recovery of muscle function and attenuation of the damaging effects of inflammation in the rabbit model. Although these observations suggest that skeletal muscle responds to cyclic compressive forces similar to those generated by clinical approaches, such as therapeutic massage, further research is needed to assess the translational efficacy of these findings. PMID:18580410

  3. Low severity coal liquefaction promoted by cyclic olefins

    SciTech Connect

    Curtis, C.W.

    1992-07-27

    Low severity coal liquefaction allows for solubilization of coal with reduced gas make. These lower severity conditions may result in some selective bond rupture. Promotion of coal solubilization through hydrogen transfer using highly active and effective hydrogen donors is the objective of this study. The highly effective donors being tested are cyclic olefins. Representative cyclic olefins are isotetralin, which is 1,4,5,8-tetrahydronaphthalene, and 1,4,5,8,9,10-hexahydroanthracene. These compounds are hydroaromatics without aromatic rings and have been shown to be highly effective donors. The objective of the work performed in this study during this quarter was to evaluate reaction parameters for low severity liquefaction reactions using the cyclic olefin, hexahydroanthracene, and the aromatic, anthracene. These model compounds were reacted under a variety of conditions to evaluate their reactivity without coal. The reactions were performed under both thermal and catalytic conditions. Finely divided catalysts from different molybdenum precursors were used to determine their activity in promoting hydrogenation and hydrogen transfer at low severity conditions. The catalysts used were Molyvan L, sulfurized oxymolybdenum dithiocarbamate, molybdenum naphthenate, and Molyvan 822, organo molybdenum dithiocarbamate.

  4. Therapeutic cyclic lipopeptides mining from microbes: latest strides and hurdles.

    PubMed

    Patel, Seema; Ahmed, Shadab; Eswari, J Satya

    2015-08-01

    Infectious diseases impose serious public health burdens and often have devastating consequences. The cyclic lipopeptides elaborated by bacteria Bacillus, Paenibacillus, Pseudomonas, Streptomyces, Serratia, Propionibacterium and fungus Fusarium are very crucial in restraining the pathogens. Composed of a peptide and a fatty acyl moiety these amphiphilic metabolites exhibit broad spectrum antimicrobial effects. Among the plethora of cyclic lipopeptides, only selective few have emerged as robust antibiotics. For their functional vigor, polymyxin, daptomycin, surfactin, iturin, fengysin, paenibacterin and pseudofactin have been integrated in mainstream healthcare. Daptomycin has been a significant part of antimicrobial arsenal since the past decade. As the magnitude of drug resistance rises in unprecedented manner, the urgency of prospecting novel cyclic lipopeptides is being perceived. Intense research has revealed the implication of these bioactive compounds stretching beyond antibacterial and antifungal. Anticancer, immunomodulatory, prosthetic parts disinfection and vaccine adjuvancy are some of the validated prospects. This review discusses the emerging applications, mechanisms governing the biological actions, role of genomics in refining structure and function, semi-synthetic analog discovery, novel strain isolation, setbacks etc. Though its beyond the scope of the current topic, for holistic purpose, the role of lipopeptides in bioremediation and crop biotechnology has been briefly outlined. This updated critique is expected to galvanize innovations and diversify therapeutic recruitment of microbial lipopeptides. PMID:26041368

  5. Cyclic process for producing methane with catalyst regeneration

    DOEpatents

    Frost, Albert C.; Risch, Alan P.

    1980-01-01

    Carbon monoxide-containing gas streams are passed over a catalyst capable of catalyzing the disproportionation of carbon monoxide so as to deposit a surface layer of active surface carbon on the catalyst essentially without formation of inactive coke thereon. The surface layer is contacted with steam and is thus converted to methane and CO.sub.2, from which a relatively pure methane product may be obtained. For practical commercial operations utilizing the two-step process of the invention of a cyclic basis, nickel, cobalt, ruthenium, thenium and alloys thereof are especially prepared for use in a metal state, with CO disproportionation being carried out at temperatures up to about 350.degree. C. and with the conversion of active surface carbon to methane being carried out by reaction with steam. The catalyst is employed in such cyclic operations without the necessity for employing a regeneration step as part of each processing cycle. Inactive carbon or coke that tends to form on the catalyst over the course of continuous operations utilizing such cyclic process is effectively and advantageously removed, on a periodic basis, in place of conventional burn off with an inert stream containing a low concentration of oxygen.

  6. Development of novel cyclic peptides as pro-apoptotic agents.

    PubMed

    Brindisi, Margherita; Maramai, Samuele; Brogi, Simone; Fanigliulo, Emanuela; Butini, Stefania; Guarino, Egeria; Casagni, Alice; Lamponi, Stefania; Bonechi, Claudia; Nathwani, Seema M; Finetti, Federica; Ragonese, Francesco; Arcidiacono, Paola; Campiglia, Pietro; Valenti, Salvatore; Novellino, Ettore; Spaccapelo, Roberta; Morbidelli, Lucia; Zisterer, Daniela M; Williams, Clive D; Donati, Alessandro; Baldari, Cosima; Campiani, Giuseppe; Ulivieri, Cristina; Gemma, Sandra

    2016-07-19

    Our recent finding that paclitaxel behaves as a peptidomimetic of the endogenous protein Nur77 inspired the design of two peptides (PEP1 and PEP2) reproducing the effects of paclitaxel on Bcl-2 and tubulin, proving the peptidomimetic nature of paclitaxel. Starting from these peptide-hits, we herein describe the synthesis and the biological investigation of linear and cyclic peptides structurally related to PEP2. While linear peptides (2a,b, 3a,b, 4, 6a-f) were found inactive in cell-based assays, biological analysis revealed a pro-apoptotic effect for most of the cyclic peptides (5a-g). Cellular permeability of 5a (and also of 2a,b) on HL60 cells was assessed through confocal microscopy analysis. Further cellular studies on a panel of leukemic cell lines (HL60, Jurkat, MEC, EBVB) and solid tumor cell lines (breast cancer MCF-7 cells, human melanoma A375 and 501Mel cells, and murine melanoma B16F1 cells) confirmed the pro-apoptotic effect of the cyclic peptides. Cell cycle analysis revealed that treatment with 5a, 5c, 5d or 5f resulted in an increase in the number of cells in the sub-G0/G1 peak. Direct interaction with tubulin (turbidimetric assay) and with microtubules (immunostaining experiments) was assessed in vitro for the most promising compounds. PMID:27150036

  7. Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets

    PubMed Central

    Ahmad, Faiyaz; Murata, Taku; Simizu, Kasumi; Degerman, Eva; Maurice, Donald; Manganiello, Vincent

    2014-01-01

    By catalyzing hydrolysis of cAMP and cGMP, cyclic nucleotide phosphodiesterases are critical regulators of their intracellular concentrations and their biological effects. Since these intracellular second messengers control many cellular homeostatic processes, dysregulation of their signals and signaling pathways initiate or modulate pathophysiological pathways related to various disease states, including erectile dysfunction, pulmonary hypertension, acute refractory cardiac failure, intermittent claudication, chronic obstructive pulmonary disease, and psoriasis. Alterations in expression of PDEs and PDE-gene mutations (especially mutations in PDE6, PDE8B, PDE11A and PDE4) have been implicated in various diseases and cancer pathologies. PDEs also play important role in formation and function of multi-molecular signaling/regulatory complexes called signalosomes. At specific intracellular locations, individual PDEs, together with pathway-specific signaling molecules, regulators, and effectors, are incorporated into specific signalosomes, where they facilitate and regulate compartmentalization of cyclic nucleotide signaling pathways and specific cellular functions. Currently, only a limited number of PDE inhibitors (PDE3, PDE4, PDE5 inhibitors) are used in clinical practice. Future paths to novel drug discovery include the crystal structure-based design approach, which has resulted in generation of more effective family-selective inhibitors, as well as burgeoning development of strategies to alter compartmentalized cyclic nucleotide signaling pathways by selectively targeting individual PDEs and their signalosome partners. PMID:25056711

  8. Nitrated cyclic GMP modulates guard cell signaling in Arabidopsis.

    PubMed

    Joudoi, Takahiro; Shichiri, Yudai; Kamizono, Nobuto; Akaike, Takaaki; Sawa, Tomohiro; Yoshitake, Jun; Yamada, Naotaka; Iwai, Sumio

    2013-02-01

    Nitric oxide (NO) is a ubiquitous signaling molecule involved in diverse physiological processes, including plant senescence and stomatal closure. The NO and cyclic GMP (cGMP) cascade is the main NO signaling pathway in animals, but whether this pathway operates in plant cells, and the mechanisms of its action, remain unclear. Here, we assessed the possibility that the nitrated cGMP derivative 8-nitro-cGMP functions in guard cell signaling. Mass spectrometry and immunocytochemical analyses showed that abscisic acid and NO induced the synthesis of 8-nitro-cGMP in guard cells in the presence of reactive oxygen species. 8-Nitro-cGMP triggered stomatal closure, but 8-bromoguanosine 3',5'-cyclic monophosphate (8-bromo-cGMP), a membrane-permeating analog of cGMP, did not. However, in the dark, 8-bromo-cGMP induced stomatal opening but 8-nitro-cGMP did not. Thus, cGMP and its nitrated derivative play different roles in the signaling pathways that lead to stomatal opening and closure. Moreover, inhibitor and genetic studies showed that calcium, cyclic adenosine-5'-diphosphate-ribose, and SLOW ANION CHANNEL1 act downstream of 8-nitro-cGMP. This study therefore demonstrates that 8-nitro-cGMP acts as a guard cell signaling molecule and that a NO/8-nitro-cGMP signaling cascade operates in guard cells. PMID:23396828

  9. Confinement Effects on Molten Thin Cyclic Polystyrene Films

    NASA Astrophysics Data System (ADS)

    He, Qiming; Narayanan, Suresh; Wu, David; Foster, Mark

    2014-03-01

    The surface fluctuations of melt film of 6k cyclic polystyrene (CPS) and its linear analog were measured using X-ray photon correlation spectroscopy (XPCS) for films of various thicknesses. The surface fluctuations of the 6k linear PS melt films 17 nm and thicker and the 6k cyclic melt films 28 nm and thicker can be described using a hydrodynamic continuum theory (HCT) that assumes the film is characterized only by the bulk viscosity. When a film of CPS is 24 nm or thinner, the behavior can no longer be captured using the HCT with bulk viscosity. The surface fluctuations behave as though the film has an effective viscosity higher than the bulk value. There is no evidence of an effective modulus in the very thin films of cyclic chains. The thickness at which confinement effects are seen for the 6k CPS chains is larger than that for the linear analogs. Use of the Advanced Photon Source at Argonne National Laboratory was supported by the DOE's Office of Science under Contract DE-AC02-06-CH11357. This work was supported by NSF Grants No CBET-0730692 and CBET-0731319.

  10. Cyanobacterial Alkanes Modulate Photosynthetic Cyclic Electron Flow to Assist Growth under Cold Stress

    PubMed Central

    Berla, Bertram M.; Saha, Rajib; Maranas, Costas D.; Pakrasi, Himadri B.

    2015-01-01

    All cyanobacterial membranes contain diesel-range C15-C19 hydrocarbons at concentrations similar to chlorophyll. Recently, two universal but mutually exclusive hydrocarbon production pathways in cyanobacteria were discovered. We engineered a mutant of Synechocystis sp. PCC 6803 that produces no alkanes, which grew poorly at low temperatures. We analyzed this defect by assessing the redox kinetics of PSI. The mutant exhibited enhanced cyclic electron flow (CEF), especially at low temperature. CEF raises the ATP:NADPH ratio from photosynthesis and balances reductant requirements of biosynthesis with maintaining the redox poise of the electron transport chain. We conducted in silico flux balance analysis and showed that growth rate reaches a distinct maximum for an intermediate value of CEF equivalent to recycling 1 electron in 4 from PSI to the plastoquinone pool. Based on this analysis, we conclude that the lack of membrane alkanes causes higher CEF, perhaps for maintenance of redox poise. In turn, increased CEF reduces growth by forcing the cell to use less energy-efficient pathways, lowering the quantum efficiency of photosynthesis. This study highlights the unique and universal role of medium-chain hydrocarbons in cyanobacterial thylakoid membranes: they regulate redox balance and reductant partitioning in these oxygenic photosynthetic cells under stress. PMID:26459862

  11. Catalytic Mechanism of Nitrile Hydratase Subsequent to Cyclic Intermediate Formation: A QM/MM Study.

    PubMed

    Kayanuma, Megumi; Shoji, Mitsuo; Yohda, Masafumi; Odaka, Masafumi; Shigeta, Yasuteru

    2016-04-01

    The catalytic mechanism of an Fe-containing nitrile hydratase (NHase) subsequent to the formation of a cyclic intermediate was investigated using a hybrid quantum mechanics/molecular mechanics (QM/MM) method. We identified the following mechanism: (i) proton transfer from βTyr72 to the substrate via αSer113, and cleavage of the S-O bond of αCys114-SO(-) and formation of a disulfide bond between αCys109 and αCys114; (ii) direct attack of a water molecule on the sulfur atom of αCys114, which resulted in the generation of both an imidic acid and a renewed sulfenic cysteine; and (iii) isomerization of the imidic acid to the amide. In addition, to clarify the role of βArg56K, which is one of the essential amino residues in the enzyme, we analyzed a βR56K mutant in which βArg56 was replaced by Lys. The results suggest that βArg56 is necessary for the formation of disulfide intermediate by stabilizing the cleavage of the S-O bond via a hydrogen bond with the oxygen atom of αCys114-SO(-). PMID:27007978

  12. Cyanobacterial Alkanes Modulate Photosynthetic Cyclic Electron Flow to Assist Growth under Cold Stress.

    PubMed

    Berla, Bertram M; Saha, Rajib; Maranas, Costas D; Pakrasi, Himadri B

    2015-01-01

    All cyanobacterial membranes contain diesel-range C15-C19 hydrocarbons at concentrations similar to chlorophyll. Recently, two universal but mutually exclusive hydrocarbon production pathways in cyanobacteria were discovered. We engineered a mutant of Synechocystis sp. PCC 6803 that produces no alkanes, which grew poorly at low temperatures. We analyzed this defect by assessing the redox kinetics of PSI. The mutant exhibited enhanced cyclic electron flow (CEF), especially at low temperature. CEF raises the ATP:NADPH ratio from photosynthesis and balances reductant requirements of biosynthesis with maintaining the redox poise of the electron transport chain. We conducted in silico flux balance analysis and showed that growth rate reaches a distinct maximum for an intermediate value of CEF equivalent to recycling 1 electron in 4 from PSI to the plastoquinone pool. Based on this analysis, we conclude that the lack of membrane alkanes causes higher CEF, perhaps for maintenance of redox poise. In turn, increased CEF reduces growth by forcing the cell to use less energy-efficient pathways, lowering the quantum efficiency of photosynthesis. This study highlights the unique and universal role of medium-chain hydrocarbons in cyanobacterial thylakoid membranes: they regulate redox balance and reductant partitioning in these oxygenic photosynthetic cells under stress. PMID:26459862

  13. Role of Heavy Atom Tunneling in Myers-Saito Cyclization of Cyclic Enyne-Cumulene Systems.

    PubMed

    Karmakar, Sharmistha; Datta, Ayan

    2016-02-11

    Direct dynamics calculation using canonical variational transtition state theory (CVT) inclusive of small curvature tunneling (SCT) reveals heavy atom tunneling in Myers-Saito cyclization of 10- and 9-membered cyclic enyne-cumulene systems like 1,6-didehydro[10]annulene and derivative of neocarzinostatin, respectively. The pure density functional theory functional, BLYP at a 6-31+G (d,p) basis set reproduce the observed reaction energies and barriers within 1.0 kcal/mol. The calculated rate constants of cyclization inclusive of heavy atom tunneling (k(CVT+SCT) = 3.26 × 10(-4) s(-1) at 222 K; t1/2 = 35 min) are in excellent agreement with experiments (t1/2 ∼ 21-31 min). Both primary and secondary kinetic isotope effect (KIE) become enhanced significantly upon inclusion of quantum mechanical tunneling. An Arrhenius plot of KIE shows measurable curvature at the experimental temperature of 222 K. The translation vector for the cyclization reactions in the transition-states (TS) show significant motion of primary and secondary carbon atoms explaining the origin of large KIE. PMID:26785136

  14. Electron Correlation Effects and Nonlinear Optical Properties of Conjugated Linear and Cyclic Chains.

    NASA Astrophysics Data System (ADS)

    Cai, Yong-Ming

    Reduced dimensionality and quantum confinement place special constraints on electronic excitations that result in unusually large nonlinear optical responses. One major purpose of this study is to provide an experimental basis for the development of a comprehensive microscopic description of the many-electron origin of the second order virtual excitation processes in quasi-one dimensional linear and cyclic chain structures. The experimental results were compared with the calculated results from configuration interaction theory for the magnitude, sign, and dispersion of beta_{rm ijk}( omega_3; omega_1,omega _2). DC field induced second harmonic generation (DCSHG) measurements of molecular units in liquid and gas phases have been performed over a broad frequency range extending from the near infrared through the visible. An infinite dilution extrapolation method which required combined experimental studies of DCSHG, dielectric constant, index of refraction, and specific volume has been employed. Theoretical gas phase values of beta_{rm ijk} can then be compared to experimental infinite dilution values. The DCSHG experimental methodology and techniques receive extensive review in this thesis in addition to the description of a new gas phase measurement.

  15. Quantum Chromodynamics

    NASA Astrophysics Data System (ADS)

    Fried, H. M.; Müller, B.; Gabellini, Y.

    2000-11-01

    The Table of Contents for the full book PDF is as follows: * Preface * Basic Concepts and Consequences of a Stochastic Vacuum Model * The Role of the QCD Vacuum in the Heavy-Quark Bound State Dynamics * Stochastic Vacuum Model and High Energy Scattering * Variational Approximations for Correlation Functions in Quantum Field Theories * Long-Range Vacuum Correlations? * Unitary Gauge Theories in Singlet Coordinates * SU(2) Gauge Theory in Covariant (Maximal) Abelian Gauges * Dynamics and Topology of the Gauge-Invariant Gauge Field in Two-Color QCD * The Vacuum Wave Function in Supersymmetric Matrix Theory * Analytic Models for the Forward Scattering Amplitude at High Energies * Extending the Frontiers -- Reconciling Accelerator and Cosmic Ray p - p Cross Sections * HERA Results on Elastic Hadronic and Sub-Hadronic Diffraction * Small-x Structure Functions and QCD Pomeron * AdS/CFT Correspondence for QCD and Pomeron Intercept at Strong Coupling * Short Introduction to QGP Dynamics * Effective Theories for Hot Non-Abelian Dynamics * Non-Perturbative Gluodynamics of High Enerry Heavy-Ion Collisions * Deriving Effective Transport Equations for Non-Abelian Plasmas * Ergodic Properties of Non-Abelian Gauge Theories * String from Large Nc Gauge Fields via Graph Summation on a P+ - x+ Lattice * Aspects of Non-Commutativity in ADS/CFT * Eikonal Scattering of Monopoles and Dyons in Dual QED * Gluon Reggeization and Sudakov Suppression via The Fock-Feynman-Schwinger Approach to QCD * Nonperturbative Gluon Radiation and Energy Dependence of Elastic Scattering * Thermal Field Theory in Equilibrium * Puzzling Aspects of Hot Quantum Fields * Color Superconductivity in Cold, Dense Quark Matter * DIS Results from HERA * Electroproduction of Vector Mesons * Probing the QED and QCD Vacua * New Developments in Cosmology * Duality and SU(1,1) coherent states in the Calogero-Moser Model * pp Elastic scattering at LHC and Signature of Chiral Phase Transition at Large |t| * A New Basis

  16. The Forbidden Quantum Adder

    NASA Astrophysics Data System (ADS)

    Alvarez-Rodriguez, U.; Sanz, M.; Lamata, L.; Solano, E.

    2015-07-01

    Quantum information provides fundamentally different computational resources than classical information. We prove that there is no unitary protocol able to add unknown quantum states belonging to different Hilbert spaces. This is an inherent restriction of quantum physics that is related to the impossibility of copying an arbitrary quantum state, i.e., the no-cloning theorem. Moreover, we demonstrate that a quantum adder, in absence of an ancillary system, is also forbidden for a known orthonormal basis. This allows us to propose an approximate quantum adder that could be implemented in the lab. Finally, we discuss the distinct character of the forbidden quantum adder for quantum states and the allowed quantum adder for density matrices.

  17. Advances in quantum teleportation

    NASA Astrophysics Data System (ADS)

    Pirandola, S.; Eisert, J.; Weedbrook, C.; Furusawa, A.; Braunstein, S. L.

    2015-10-01

    Quantum teleportation is one of the most important protocols in quantum information. By exploiting the physical resource of entanglement, quantum teleportation serves as a key primitive across a variety of quantum information tasks and represents an important building block for quantum technologies, with a pivotal role in the continuing progress of quantum communication, quantum computing and quantum networks. Here we summarize the basic theoretical ideas behind quantum teleportation and its variant protocols. We focus on the main experiments, together with the technical advantages and disadvantages associated with the use of the various technologies, from photonic qubits and optical modes to atomic ensembles, trapped atoms and solid-state systems. After analysing the current state-of-the-art, we finish by discussing open issues, challenges and potential future implementations.

  18. The Forbidden Quantum Adder.

    PubMed

    Alvarez-Rodriguez, U; Sanz, M; Lamata, L; Solano, E

    2015-01-01

    Quantum information provides fundamentally different computational resources than classical information. We prove that there is no unitary protocol able to add unknown quantum states belonging to different Hilbert spaces. This is an inherent restriction of quantum physics that is related to the impossibility of copying an arbitrary quantum state, i.e., the no-cloning theorem. Moreover, we demonstrate that a quantum adder, in absence of an ancillary system, is also forbidden for a known orthonormal basis. This allows us to propose an approximate quantum adder that could be implemented in the lab. Finally, we discuss the distinct character of the forbidden quantum adder for quantum states and the allowed quantum adder for density matrices. PMID:26153134

  19. Quantum junction solar cells.

    PubMed

    Tang, Jiang; Liu, Huan; Zhitomirsky, David; Hoogland, Sjoerd; Wang, Xihua; Furukawa, Melissa; Levina, Larissa; Sargent, Edward H

    2012-09-12

    Colloidal quantum dot solids combine convenient solution-processing with quantum size effect tuning, offering avenues to high-efficiency multijunction cells based on a single materials synthesis and processing platform. The highest-performing colloidal quantum dot rectifying devices reported to date have relied on a junction between a quantum-tuned absorber and a bulk material (e.g., TiO(2)); however, quantum tuning of the absorber then requires complete redesign of the bulk acceptor, compromising the benefits of facile quantum tuning. Here we report rectifying junctions constructed entirely using inherently band-aligned quantum-tuned materials. Realizing these quantum junction diodes relied upon the creation of an n-type quantum dot solid having a clean bandgap. We combine stable, chemically compatible, high-performance n-type and p-type materials to create the first quantum junction solar cells. We present a family of photovoltaic devices having widely tuned bandgaps of 0.6-1.6 eV that excel where conventional quantum-to-bulk devices fail to perform. Devices having optimal single-junction bandgaps exhibit certified AM1.5 solar power conversion efficiencies of 5.4%. Control over doping in quantum solids, and the successful integration of these materials to form stable quantum junctions, offers a powerful new degree of freedom to colloidal quantum dot optoelectronics. PMID:22881834

  20. Reliable quantum communication over a quantum relay channel

    SciTech Connect

    Gyongyosi, Laszlo; Imre, Sandor

    2014-12-04

    We show that reliable quantum communication over an unreliable quantum relay channels is possible. The coding scheme combines the results on the superadditivity of quantum channels and the efficient quantum coding approaches.

  1. Expected number of quantum channels in quantum networks

    PubMed Central

    Chen, Xi; Wang, He-Ming; Ji, Dan-Tong; Mu, Liang-Zhu; Fan, Heng

    2015-01-01

    Quantum communication between nodes in quantum networks plays an important role in quantum information processing. Here, we proposed the use of the expected number of quantum channels as a measure of the efficiency of quantum communication for quantum networks. This measure quantified the amount of quantum information that can be teleported between nodes in a quantum network, which differs from classical case in that the quantum channels will be consumed if teleportation is performed. We further demonstrated that the expected number of quantum channels represents local correlations depicted by effective circles. Significantly, capacity of quantum communication of quantum networks quantified by ENQC is independent of distance for the communicating nodes, if the effective circles of communication nodes are not overlapped. The expected number of quantum channels can be enhanced through transformations of the lattice configurations of quantum networks via entanglement swapping. Our results can shed lights on the study of quantum communication in quantum networks. PMID:26173556

  2. Expected number of quantum channels in quantum networks.

    PubMed

    Chen, Xi; Wang, He-Ming; Ji, Dan-Tong; Mu, Liang-Zhu; Fan, Heng

    2015-01-01

    Quantum communication between nodes in quantum networks plays an important role in quantum information processing. Here, we proposed the use of the expected number of quantum channels as a measure of the efficiency of quantum communication for quantum networks. This measure quantified the amount of quantum information that can be teleported between nodes in a quantum network, which differs from classical case in that the quantum channels will be consumed if teleportation is performed. We further demonstrated that the expected number of quantum channels represents local correlations depicted by effective circles. Significantly, capacity of quantum communication of quantum networks quantified by ENQC is independent of distance for the communicating nodes, if the effective circles of communication nodes are not overlapped. The expected number of quantum channels can be enhanced through transformations of the lattice configurations of quantum networks via entanglement swapping. Our results can shed lights on the study of quantum communication in quantum networks. PMID:26173556

  3. Quantum thermodynamics of general quantum processes

    NASA Astrophysics Data System (ADS)

    Binder, Felix; Vinjanampathy, Sai; Modi, Kavan; Goold, John

    2015-03-01

    Accurately describing work extraction from a quantum system is a central objective for the extension of thermodynamics to individual quantum systems. The concepts of work and heat are surprisingly subtle when generalizations are made to arbitrary quantum states. We formulate an operational thermodynamics suitable for application to an open quantum system undergoing quantum evolution under a general quantum process by which we mean a completely positive and trace-preserving map. We derive an operational first law of thermodynamics for such processes and show consistency with the second law. We show that heat, from the first law, is positive when the input state of the map majorizes the output state. Moreover, the change in entropy is also positive for the same majorization condition. This makes a strong connection between the two operational laws of thermodynamics.

  4. Quantum thermodynamics of general quantum processes.

    PubMed

    Binder, Felix; Vinjanampathy, Sai; Modi, Kavan; Goold, John

    2015-03-01

    Accurately describing work extraction from a quantum system is a central objective for the extension of thermodynamics to individual quantum systems. The concepts of work and heat are surprisingly subtle when generalizations are made to arbitrary quantum states. We formulate an operational thermodynamics suitable for application to an open quantum system undergoing quantum evolution under a general quantum process by which we mean a completely positive and trace-preserving map. We derive an operational first law of thermodynamics for such processes and show consistency with the second law. We show that heat, from the first law, is positive when the input state of the map majorizes the output state. Moreover, the change in entropy is also positive for the same majorization condition. This makes a strong connection between the two operational laws of thermodynamics. PMID:25871066

  5. A model of quantum communication device for quantum hashing

    NASA Astrophysics Data System (ADS)

    Vasiliev, A.

    2016-02-01

    In this paper we consider a model of quantum communications between classical computers aided with quantum processors, connected by a classical and a quantum channel. This type of communications implying both classical and quantum messages with moderate use of quantum processing is implicitly used in many quantum protocols, such as quantum key distribution or quantum digital signature. We show that using the model of a quantum processor on multiatomic ensembles in the common QED cavity we can speed up quantum hashing, which can be the basis of quantum digital signature and other communication protocols.

  6. Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein.

    PubMed

    Underwood, Adam J; Zhang, Yang; Metzger, Dennis W; Bai, Guangchun

    2014-12-01

    Cyclic di-AMP (c-di-AMP) is a recently recognized bacterial signaling molecule. In this study, a competitive enzyme-linked immunosorbent assay (ELISA) for the quantification of c-di-AMP was developed using a novel pneumococcal c-di-AMP binding protein (CabP). With this method, c-di-AMP concentrations in biological samples can be quickly and accurately quantified. PMID:25239824

  7. Correlation between cyclic fatigue and the bending properties of nickel titanium endodontic instruments.

    PubMed

    Piao, Jindan; Miyara, Kana; Ebihara, Arata; Nomura, Naoyuki; Hanawa, Takao; Suda, Hideaki

    2014-01-01

    The effects of cyclic fatigue on bending properties of NiTi endodontic instruments were investigated. Sixteen Profiles(®) were divided into two groups (A, and B). The sequence of cantilever bending test and cyclic fatigue test was alternated repeatedly until file separation occurred. In the cyclic fatigue test, the instrument curvature was 19° in group A and 38° in group B. Fractographic examination was performed to determine fracture patterns. In group A, there were significant differences between the bending load values measured before the cyclic fatigue test and the last cantilever bending test before instrument fracture at each deflection (p<0.05). Fractographic examination showed the specific patterns of cyclic fatigue fracture. The stress required to induce martensitic transformation might be reduced due to the softening behavior caused by the cyclic fatigue under the relaxation condition of the superelasticity range (group A). The SEM images were able to display specific patterns indicating cyclic fatigue fracture. PMID:25087661

  8. Activation of the adenylyl cyclase/cyclic AMP/protein kinase A pathway in endothelial cells exposed to cyclic strain

    NASA Technical Reports Server (NTRS)

    Cohen, C. R.; Mills, I.; Du, W.; Kamal, K.; Sumpio, B. E.

    1997-01-01

    The aim of this study was to assess the involvement of the adenylyl cyclase/cyclic AMP/protein kinase A pathway (AC) in endothelial cells (EC) exposed to different levels of mechanical strain. Bovine aortic EC were seeded to confluence on flexible membrane-bottom wells. The membranes were deformed with either 150 mm Hg (average 10% strain) or 37.5 mm Hg (average 6% strain) vacuum at 60 cycles per minute (0.5 s strain; 0.5 s relaxation) for 0-60 min. The results demonstrate that at 10% average strain (but not 6% average strain) there was a 1.5- to 2.2-fold increase in AC, cAMP, and PKA activity by 15 min when compared to unstretched controls. Further studies revealed an increase in cAMP response element binding protein in EC subjected to the 10% average strain (but not 6% average strain). These data support the hypothesis that cyclic strain activates the AC/cAMP/PKA signal transduction pathway in EC which may occur by exceeding a strain threshold and suggest that cyclic strain may stimulate the expression of genes containing cAMP-responsive promoter elements.

  9. Evaluation of the gas production economics of the gas hydrate cyclic thermal injection model. [Cyclic thermal injection

    SciTech Connect

    Kuuskraa, V.A.; Hammersheimb, E.; Sawyer, W.

    1985-05-01

    The objective of the work performed under this directive is to assess whether gas hydrates could potentially be technically and economically recoverable. The technical potential and economics of recovering gas from a representative hydrate reservoir will be established using the cyclic thermal injection model, HYDMOD, appropriately modified for this effort, integrated with economics model for gas production on the North Slope of Alaska, and in the deep offshore Atlantic. The results from this effort are presented in this document. In Section 1, the engineering cost and financial analysis model used in performing the economic analysis of gas production from hydrates -- the Hydrates Gas Economics Model (HGEM) -- is described. Section 2 contains a users guide for HGEM. In Section 3, a preliminary economic assessment of the gas production economics of the gas hydrate cyclic thermal injection model is presented. Section 4 contains a summary critique of existing hydrate gas recovery models. Finally, Section 5 summarizes the model modification made to HYDMOD, the cyclic thermal injection model for hydrate gas recovery, in order to perform this analysis.

  10. Almost quantum correlations.

    PubMed

    Navascués, Miguel; Guryanova, Yelena; Hoban, Matty J; Acín, Antonio

    2015-01-01

    Quantum theory is not only successfully tested in laboratories every day but also constitutes a robust theoretical framework: small variations usually lead to implausible consequences, such as faster-than-light communication. It has even been argued that quantum theory may be special among possible theories. Here we report that, at the level of correlations among different systems, quantum theory is not so special. We define a set of correlations, dubbed 'almost quantum', and prove that it strictly contains the set of quantum correlations but satisfies all-but-one of the proposed principles to capture quantum correlations. We present numerical evidence that the remaining principle is satisfied too. PMID:25697645

  11. A multiplexed quantum memory.

    PubMed

    Lan, S-Y; Radnaev, A G; Collins, O A; Matsukevich, D N; Kennedy, T A; Kuzmich, A

    2009-08-01

    A quantum repeater is a system for long-distance quantum communication that employs quantum memory elements to mitigate optical fiber transmission losses. The multiplexed quantum memory (O. A. Collins, S. D. Jenkins, A. Kuzmich, and T. A. B. Kennedy, Phys. Rev. Lett. 98, 060502 (2007)) has been shown theoretically to reduce quantum memory time requirements. We present an initial implementation of a multiplexed quantum memory element in a cold rubidium gas. We show that it is possible to create atomic excitations in arbitrary memory element pairs and demonstrate the violation of Bell's inequality for light fields generated during the write and read processes. PMID:19654771

  12. Quantum chimera states

    NASA Astrophysics Data System (ADS)

    Viennot, David; Aubourg, Lucile

    2016-02-01

    We study a theoretical model of closed quasi-hermitian chain of spins which exhibits quantum analogues of chimera states, i.e. long life classical states for which a part of an oscillator chain presents an ordered dynamics whereas another part presents a disordered dynamics. For the quantum analogue, the chimera behaviour deals with the entanglement between the spins of the chain. We discuss the entanglement properties, quantum chaos, quantum disorder and semi-classical similarity of our quantum chimera system. The quantum chimera concept is novel and induces new perspectives concerning the entanglement of multipartite systems.

  13. Pulsed quantum optomechanics

    PubMed Central

    Vanner, M. R.; Pikovski, I.; Cole, G. D.; Kim, M. S.; Brukner, Č.; Hammerer, K.; Milburn, G. J.; Aspelmeyer, M.

    2011-01-01

    Studying mechanical resonators via radiation pressure offers a rich avenue for the exploration of quantum mechanical behavior in a macroscopic regime. However, quantum state preparation and especially quantum state reconstruction of mechanical oscillators remains a significant challenge. Here we propose a scheme to realize quantum state tomography, squeezing, and state purification of a mechanical resonator using short optical pulses. The scheme presented allows observation of mechanical quantum features despite preparation from a thermal state and is shown to be experimentally feasible using optical microcavities. Our framework thus provides a promising means to explore the quantum nature of massive mechanical oscillators and can be applied to other systems such as trapped ions. PMID:21900608

  14. Quantum information causality.

    PubMed

    Pitalúa-García, Damián

    2013-05-24

    How much information can a transmitted physical system fundamentally communicate? We introduce the principle of quantum information causality, which states the maximum amount of quantum information that a quantum system can communicate as a function of its dimension, independently of any previously shared quantum physical resources. We present a new quantum information task, whose success probability is upper bounded by the new principle, and show that an optimal strategy to perform it combines the quantum teleportation and superdense coding protocols with a task that has classical inputs. PMID:23745844

  15. Quantum code for quantum error characterization

    NASA Astrophysics Data System (ADS)

    Omkar, S.; Srikanth, R.; Banerjee, Subhashish

    2015-05-01

    A quantum error-correcting code is a subspace C such that allowed errors acting on any state in C can be corrected. A quantum code for which state recovery is only required up to a logical rotation within C can be used for the detection of errors, but not for quantum error correction. Such a code with a stabilizer structure, which we call an "ambiguous stabilizer code" (ASC), can nevertheless be useful for the characterization of quantum dynamics (CQD). The use of ASCs can help lower the size of CQD probe states used, but at the cost of an increased number of operations.

  16. Feasible quantum engineering of quantum multiphoton superpositions

    NASA Astrophysics Data System (ADS)

    Stobińska, Magdalena

    2015-02-01

    We examine an experimental setup implementing a family of quantum non-Gaussian filters. The filters can be applied to an arbitrary two-mode input state. We assume realistic photodetection in the filtering process and explore two different models of inefficient detections: a beam splitter of a small reflectivity located in front of a perfect detector and a Weierstrass transform applied to the unperturbed measurement outcomes. We explicitly give an operator which describes the coherent action of the filters in the realistic experimental conditions. The filtered states may find applications in quantum metrology, quantum communication and other quantum tasks.

  17. The Quantum Underground: Early quantum theory textbooks

    NASA Astrophysics Data System (ADS)

    Gearhart, Clayton

    2011-04-01

    Quantum theory had its beginnings in 1900, when Max Planck derived his famous formula for the energy density of black-body radiation. But the early quantum theory textbooks we remember today--for example, those of Arnold Summerfeld (1919), Fritz Reiche (1921), and a shorter Report by James Jeans (1914), did not appear until some years later, and all were written by physicists who were themselves active participants in early quantum theory. Surprisingly, not all early texts fit this pattern. Reiche himself had written a review article on quantum theory for general readers in Die Naturwissenschaften in 1913, long before his research had shifted to quantum topics. And a year later, textbooks by Hermann Sieveking and Sigfried Valentiner treated quantum theory for students and non-specialists, although neither was active in quantum theoretical research. A third and better known author, Owen Richardson, also treated quantum theory in a 1914 book on electromagnetism. I will describe these early and little-known treatments of quantum theory, all of which were written by physicists whose primary research and professional interests lay elsewhere.

  18. Quantum Kolmogorov complexity and bounded quantum memory

    SciTech Connect

    Miyadera, Takayuki

    2011-04-15

    The effect of bounded quantum memory in a primitive information protocol has been examined using the quantum Kolmogorov complexity as a measure of information. We employed a toy two-party protocol in which Bob, by using a bounded quantum memory and an unbounded classical memory, estimates a message that was encoded in qubits by Alice in one of the bases X or Z. Our theorem gave a nontrivial effect of the memory boundedness. In addition, a generalization of the uncertainty principle in the presence of quantum memory has been obtained.

  19. Quantum optics. Gravity meets quantum physics

    SciTech Connect

    Adams, Bernhard W.

    2015-02-27

    Albert Einstein’s general theory of relativity is a classical formulation but a quantum mechanical description of gravitational forces is needed, not only to investigate the coupling of classical and quantum systems but simply to give a more complete description of our physical surroundings. In this issue of Nature Photonics, Wen-Te Liao and Sven Ahrens reveal a link between quantum and gravitational physics. They propose that in the quantum-optical effect of superradiance, the world line of electromagnetic radiation is changed by the presence of a gravitational field.

  20. Work and quantum phase transitions: quantum latency.

    PubMed

    Mascarenhas, E; Bragança, H; Dorner, R; França Santos, M; Vedral, V; Modi, K; Goold, J

    2014-06-01

    We study the physics of quantum phase transitions from the perspective of nonequilibrium thermodynamics. For first-order quantum phase transitions, we find that the average work done per quench in crossing the critical point is discontinuous. This leads us to introduce the quantum latent work in analogy with the classical latent heat of first order classical phase transitions. For second order quantum phase transitions the irreversible work is closely related to the fidelity susceptibility for weak sudden quenches of the system Hamiltonian. We demonstrate our ideas with numerical simulations of first, second, and infinite order phase transitions in various spin chain models. PMID:25019721