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1

todasuvida: Las personas con diabetes son ms  

E-print Network

diabetes Controlesu todasuvida: Las personas con diabetes son más propensas a padecer de enfermedades del corazón que quienes no tienen diabetes. Boletín 631 D Las personas con diabetes tienen mayor- res relacionados con la diabetes, como derrame cerebral, mala circulación en las piernas y pies e

2

con Diabetes Su diabetes s se puede controlar!  

E-print Network

Do Well, Be Well con Diabetes ¡Su diabetes sí se puede controlar! Educational programs of the Texas, and the County Commissioners Courts of Texas Cooperating. to develop diabetes self-care skills, to improve eating habits and maintain good nutrition, to increase physical activity, to prevent diabetes complications

3

Do Well, Be Well with Diabetes 2013 1 Formulario de Registro para Personas con Diabetes Formulario de Registro para Personas con Diabetes 2013  

E-print Network

Do Well, Be Well with Diabetes ­ 2013 1 Formulario de Registro para Personas con Diabetes Formulario de Registro para Personas con Diabetes ­ 2013 Si usted NO TIENE diabetes, por favor NO LLENE este sobre diabetes en el Condado de _______________. D. El código postal en mi casa es __ __ __ __ __. E

4

Do Well, Be Well with Diabetes 2013 1 Formulario de Conclusin para Personas con Diabetes Formulario de Conclusin para Personas con Diabetes 201  

E-print Network

Do Well, Be Well with Diabetes ­ 2013 1 Formulario de Conclusión para Personas con Diabetes Formulario de Conclusión para Personas con Diabetes ­ 201 Si usted NO TIENE diabetes, por favor NO LLENE este últimos cuatro números de mi número telefónico son __ __ __ __. C. Marque todas las clases sobre diabetes

5

Meal Planning for People with Diabetes, 2nd Edition = Planificacion de Comidas para Personas con Diabetes, 2 Edicion.  

ERIC Educational Resources Information Center

This booklet provides information about diabetes and meal planning particularly designed for migrant individuals. The first section defines diabetes, explains different types of diabetes, lists results of uncontrolled diabetes, and describes the goals and components of a diabetic meal plan. The second section explains the exchange system of

National Migrant Resource Program, Inc., Austin, TX.

6

Niveles de Depresin y Sintomatologa caracterstica en pacientes adultos con Diabetes Mellitus tipo 2  

Microsoft Academic Search

Adults with Diabetes are twice more likely to suffer depression, and for this reason is important to know the relationship between depression, diabetes and how this affects an individuals quality of life. The aim of this study was to determine in adult type 2 diabetic patients, depression levels and its main symptoms. 40 type 2 diabetic patients, between 30 and

N Pineda; V Bermdez; C Cano; Flix Gmez

7

Diabetes  

NSDL National Science Digital Library

Diabetes, in a variety of forms, affects many Americans and is the 4th leading cause of death by disease in the US. Diabetes is fundamentally a disease in which the body cannot produce or effectively use a critical hormone called insulin. Untreated / unmanaged diabetes can lead to blindness, kidney failure, heart disease, loss of limbs and stroke.

Dr. Leslie Nader (MSMR)

1993-04-14

8

Apego al tratamiento farmacolgico en pacientes con diagnstico de diabetes mellitus tipo 2  

Microsoft Academic Search

Objective. To establish the frequency of compliance to pharmacological therapy, and to identify non-compliance factors, in relation to metabolic control on patients with type-II diabetes mellitus. Material and methods. A com- parative cross-sectional study was conducted between 1997 and 1998, among 150 type-II diabetic patients, at the Family Medicine Unit No. 33, of the Mexican Institute of Social Security, in

Blanca Rosa Durn-Varela; Blanca Rivera-Chavira; Ernesto Franco-Gallegos

2001-01-01

9

[Diabetes].  

PubMed

The new recommendations on the pharmacological treatment of type 2 diabetes have introduced two important changes. The first is to have common strategies between European and American diabetes societies. The second, which is certainly the most significant, is to develop a patient centred approach suggesting therapies that take into account the patient's preferences and use of decision support tools. The individual approach integrates six factors: the capacity and motivation of the patient to manage his illness and its treatment, the risks of hypoglycemia, the life expectancy, the presence of co-morbidities and vascular complications, as well as the financial resources of the patient and the healthcare system. Treatment guidelines for cardiovascular risk reduction in diabetic remains the last point to develop. PMID:23409644

Ruiz, J

2013-01-16

10

DIABETES  

PubMed Central

Limited options for clinical management of patients with juvenile-onset diabetes mellitus call for a novel therapeutic paradigm. Two innovative studies support endoplasmic reticulum as an emerging target for combating both autoimmune and heritable forms of this disease. PMID:24393784

Urano, Fumihiko

2014-01-01

11

Stay at a Healthy Weight. Tips for Kids with Type 2 Diabetes = Mantente en un Peso Saludable. Consejos Para Muchachos con Diabetes Tipo 2  

ERIC Educational Resources Information Center

A healthy weight means you are not too fat or too thin. Your doctor may have said that you should not gain more weight or that you need to lose a few pounds. If you have diabetes and are overweight, you are not alone. The steps you take to manage your weight will help you feel better and may improve your blood sugar or glucose (GLOO-kos) levels.

US Department of Health and Human Services, 2005

2005-01-01

12

Coste-efectividad de la insulina de accin intermedia o larga contra Exenatide en pacientes con diabetes mellitus tipo 2 no ptimamente controlados con antidiabticos orales Cost-effectiveness of intermediate or long-acting insulin versus Exenatide in type 2 diabetes mellitus patients not optimally controlled on dual oral diabetes medications  

Microsoft Academic Search

Objective: To better understand exenatide's role in the treatment of type 2 diabetes, this analysis assessed its cost-effectiveness in comparison to an intermediate (NPH) and long-acting insulin (glargine). Exenatide is a recently approved medication for the treatment of type 2 diabetes for use in addition to frequently used oral diabetes medications. Methods: Two studies were identified by a Medline search

Krystal L. EDWARDS; Brian K. IRONS; Tom XU

13

with Diabetes With Diabetes  

E-print Network

with Diabetes Dining A Program For People With Diabetes And Their Families Now is the time to take charge of your diabetes. What is diabetes? Diabetes is a common, serious, and costly disease. The Centers for Disease Control and Prevention (CDC) has reported that diabetes is the 6th leading cause of death

14

Women and Diabetes -- Diabetes Medicines  

MedlinePLUS

... Sold Diabetes Treatments Women's Health Publications Women and Diabetes - Diabetes Medicines Diabetes can make it hard to control ... 1-800-332-1088 to request a form. Diabetes Medicines The different kinds of diabetes medicines are ...

15

[Treatment of type 2 diabetes mellitus in patients with chronic kidney disease. Grupo de Trabajo para el Documento de Consenso sobre el tratamiento de la diabetes tipo 2 en el paciente con enfermedad renal crnica].  

PubMed

Chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) are highly prevalent chronic diseases, which represent an important public health problem and require a multidisciplinary management. T2DM is the main cause of CKD and it also causes a significant comorbidity with regard to non-diabetic nephropathy. Patients with diabetes and kidney disease represent a special risk group as they have higher morbi-mortality as well as higher risk of hypoglycemia than diabetic individuals with a normal kidney function. Treatment of T2DM in patients with CKD is controversial because of the scarcity of available evidence. The current consensus report aims to ease the appropriate selection and dosage of antidiabetic treatments as well as the establishment of safety objectives of glycemic control in patients with CKD. PMID:24268912

Gmez-Huelgas, Ricardo; Martnez-Castelao, Alberto; Artola, Sara; Grriz, Jos Luis; Menndez, Edelmiro

2014-01-21

16

Diabetic Neuropathy  

MedlinePLUS

NINDS Diabetic Neuropathy Information Page Table of Contents (click to jump to sections) What is Diabetic Neuropathy? Is there ... Trials Organizations Additional resources from MedlinePlus What is Diabetic Neuropathy? Diabetic neuropathy is a peripheral nerve disorder ...

17

Diabetes Medicines  

MedlinePLUS

Diabetes means your blood glucose, or blood sugar, levels are too high. If you can't control your diabetes with wise food choices and physical activity, you may need diabetes medicines. The kind of medicine you take depends ...

18

Monogenic Diabetes  

MedlinePLUS

... types are Permanent neonatal diabetes, a lifelong condition Transient neonatal diabetes, which goes away during infancy but ... a sulfonylurea but others require insulin. Infants with transient neonatal diabetes may require insulin at first but ...

19

Diabetic Dermopathy  

MedlinePLUS

newsletter | contact Share | Diabetic Dermopathy Information for adults A A A Brown, scar-like, slightly elevated lesions on the legs are typical in long-standing diabetics. Overview Diabetic dermopathy, also known as shin spots ...

20

Diabetic ketoacidosis  

MedlinePLUS

Diabetic ketoacidosis is a life-threatening problem that affects people with diabetes . It occurs when the body ... are poisonous. This condition is known as ketoacidosis. Diabetic ketoacidosis is sometimes the first sign of type ...

21

Canadian Diabetes Association National Nutrition Committee Technical Review: Nonnutritive Intense Sweeteners in Diabetes Management  

Microsoft Academic Search

The current Canadian Diabetes Association Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada state that up to 10% of daily calories can be derived from sugars. However, individuals with diabetes may also be relying on alternative, low-calorie sweetening agents (providing little or no calories along with sweet taste) to con- trol carbohydrate intake, blood glucose, weight

Rjeanne Gougeon; Mark Spidel; Kristy Lee; Catherine J. Field

2004-01-01

22

Diabetes Travel Tips Video  

MedlinePLUS

... Resources > Diabetes Travel Tips Video Diabetes Travel Tips Video Diabetes doesnt keep David from traveling. But ... Subtitle Diabetes Travel Tips Transcript Diabetes Travel Tips Video (MP4) Keywords: self-management , behavior change , National Diabetes ...

23

Diabetes Insipidus  

MedlinePLUS

Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This ... is almost all water. DI is different from diabetes mellitus (DM), which involves insulin problems and high ...

24

Diabetes Complications  

MedlinePLUS

If you have diabetes, your blood glucose, or blood sugar, levels are too high. Over time, this can cause problems with other body ... as your kidneys, nerves, feet, and eyes. Having diabetes can also put you at a higher risk ...

25

Diabetic Retinopathy  

MedlinePLUS

... Prevalence Rates for Diabetic Retinopathy by Age, and Race/Ethnicity Age White Black Hispanic Other All 40- ... 0558 2010 Prevalence Rates of Diabetic Retinopathy by Race All White Black Hispanic Other Prevalence 0.054 ...

26

Diabetes Complications  

MedlinePLUS

... the potential complications of type 1 diabetes are: Cardiovascular disease Cardiovascular disease, a range of blood vessel system diseases that ... with diabetes. The two most common types of cardiovascular disease are coronary heart disease, caused by fatty deposits ...

27

Diabetes - Introduction  

MedlinePLUS Videos and Cool Tools

... affects millions of Americans every year. Your health care provider may have informed you that you have ... Of Diabetes Diabetes is detected when your health care provider finds a high level of sugar in ...

28

Diabetic Emergencies  

MedlinePLUS

... PDF What to do in a Medical Emergency Diabetic Emergencies It is estimated that more than 20 ... they have it. The best way to prevent diabetic emergencies is to effectively manage the disease through ...

29

Diabetes insipidus - nephrogenic  

MedlinePLUS

Nephrogenic diabetes insipidus; Acquired nephrogenic diabetes insipidus; Congenital diabetes insipidus ... be removed and returned to the blood. Nephrogenic diabetes insipidus (NDI) occurs when the kidney tubules do ...

30

Diabetes and kidney disease  

MedlinePLUS

Diabetic nephropathy; Nephropathy - diabetic; Diabetic glomerulosclerosis; Kimmelstiel-Wilson disease ... blood pressure. This is because if you have diabetic nephropathy, you likely also have high blood pressure. ...

31

Diabetes Education Program INTRODUCTION TO DIABETES  

E-print Network

Diabetes Education Program INTRODUCTION TO DIABETES If you have just learned that you have diabetes or already have diabetes and have been told that a change in therapy is needed, you may feel frightened you to learn how to better manage your diabetes. WHAT IS DIABETES? Diabetes is a condition in which

Oliver, Douglas L.

32

[Diabetic neuopathy].  

PubMed

In view of increasing number of elderly diabetic patients and their westernized lifestyle, diabetic foot and fractures due to fall attributable to diabetic neuropathy may be common diseases which disturb patients' QOL. Since any therapeutic drugs for patients with diabetic neuropathy have not been fully accepted, much attention should be paid to intensification of self-care for foot lesion and exercise and balance training through education. Some of them may show orthostatic hypotension, gastroparesis, etc. Others may complain of pain in limbs. Taken together, management for elderly diabetic patients may well be achieved through education and with symptomatic therapy. PMID:24397176

Yasuda, Hitoshi

2013-11-01

33

The Diabetes EDUCATOR Volume 37, Number 6, November/December 2011  

E-print Network

The Diabetes EDUCATOR 770 Volume 37, Number 6, November/December 2011 Ninfa C. Peña-Purcell, Ph Controlar Mi Diabetes! program (formerly Do Well, Be Well con Diabetes program) was supported by the US-46100-05910). DOI: 10.1177/0145721711423319 © 2011 The Author(s) An Empowerment-Based Diabetes Self

Boggess, May M.

34

Genetics of Diabetes  

MedlinePLUS

... A A A Listen En Espaol Genetics of Diabetes You've probably wondered how you developed diabetes. ... to develop diabetes than others. What Leads to Diabetes? Type 1 and type 2 diabetes have different ...

35

Diabetes Mellitus  

Microsoft Academic Search

Diabetic nephropathy is a complication of diabetes mellitus (DM) that can be prevented or slowed by medical and nutritional\\u000a interventions. Glycemic control coupled with the management of hypertension and dyslipidemia can alter the progression of\\u000a chronic kidney disease (CKD) in stages 1 through 4. Careful management of carbohydrate (CHO) intake is essential to diabetes\\u000a meal planning, emphasizing how much and

Joni J. Pagenkemper

36

Preventing Diabetes  

MedlinePLUS

... percent of their body weight significantly reduce their risk of type 2 diabetes. For example, if you weigh 200 pounds, losing only 10 pounds could make a difference. Avoid crash diets. Instead, eat less of the foods you ...

37

Diabetic Nephropathy  

MedlinePLUS

... in your urine, this could mean that your diabetes has damaged the holes in the blood vessels of your kidneys. This makes the holes big enough for protein and other nutrients your body needs to leak ...

38

Gestational diabetes  

MedlinePLUS

... baby is more likely to have periods of low blood sugar ( hypoglycemia ) during the first few days of life. Mothers with gestational diabetes have an increased risk for high blood pressure during pregnancy. There is a slightly increased risk ...

39

Diabetic Neuropathies  

Microsoft Academic Search

Diabetic neuropathies (DN) are a heterogeneous group of disorders that include a wide range of abnormalities. They can be\\u000a focal or diffuse, proximal or distal, affecting both peripheral and autonomic nervous systems, causing morbidity with significant\\u000a impact on the quality of life of the person with diabetes, resulting in early mortality. Distal symmetric polyneuropathy,\\u000a the most common form of DN,

Aaron I. Vinik

40

Women and Diabetes  

MedlinePLUS Videos and Cool Tools

... Food Safety for People with Diabetes Your Glucose Meter - easy-to-read booklet for women Other FDA ... on Diabetes How to Report Problems with Glucose Meters Diabetes Treatments Some people with diabetes need to ...

41

Diabetes and Pregnancy  

MedlinePLUS

Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. When ... pregnant women in the United States get gestational diabetes. Gestational diabetes is diabetes that happens for the ...

42

Diabetic Heart Disease  

MedlinePLUS

... from the NHLBI on Twitter. What Is Diabetic Heart Disease? The term "diabetic heart disease" (DHD) refers to ... Kidney Diseases' Introduction to Diabetes Web page. What Heart Diseases Are Involved in Diabetic Heart Disease? DHD may ...

43

Diabetic dyslipidemia.  

PubMed

Diabetic dyslipidemia is characterized by elevated fasting and postprandial triglycerides, low HDL-cholesterol, elevated LDL-cholesterol and the predominance of small dense LDL particles. These lipid changes represent the major link between diabetes and the increased cardiovascular risk of diabetic patients. The underlying pathophysiology is only partially understood. Alterations of insulin sensitive pathways, increased concentrations of free fatty acids and low grade inflammation all play a role and result in an overproduction and decreased catabolism of triglyceride rich lipoproteins of intestinal and hepatic origin. The observed changes in HDL and LDL are mostly sequence to this. Lifestyle modification and glucose control may improve the lipid profile but statin therapy mediates the biggest benefit with respect to cardiovascular risk reduction. Therefore most diabetic patients should receive statin therapy. The role of other lipid lowering drugs, such as ezetimibe, fibrates, omega-3 fatty acids, niacin and bile acid sequestrants is less well defined as they are characterized by largely negative outcome trials. This review examines the pathophysiology of diabetic dyslipidemia and its relationship to cardiovascular diseases. Management approaches will also be discussed. PMID:25242435

Wu, Liya; Parhofer, Klaus G

2014-12-01

44

Diabetic mastopathy.  

PubMed

Diabetic mastopathy is an uncommon condition found in patients with long-standing diabetic mellitus (DM). Although benign in nature, it can sometimes not be distinguishable from breast carcinoma, and may lead to unnecessary anxiety or intervention. Clinicopathologic features of 10 patients were reviewed in detail. Only three of the 10 patients had type I DM. All patients had over a 10-year history of DM, and presented with unilateral, solitary, palpable breast mass, ranging in size from 1.5 to 5 cm. Radiologic and pathologic features of each patient were described. None of the patients in our series developed malignancy during the follow-up period. Diabetic mastopathy is a benign condition and not unique to type I DM. Surgeons should be aware of this distinct fibroinflammatory breast condition and its association with long-standing DM. PMID:23895671

Chan, Chiu-lung Richie; Ho, Ronnie S L; Shek, Tony W H; Kwong, Ava

2013-01-01

45

[Diabetics travelling].  

PubMed

As anyone else, diabetic patients are confronted to professional or private travels. This article is meant to gather some practical recommendations to allow patients to travel safely. All travels must be thoroughly prepared and diabetes must stabilised at best before departure. To avoid severe hypoglycaemias and ketosis are the medical objectives. It is therefore essential that patients take with them their injection material and a sufficient carbohydrate back up. The prevention of diarrheas and vomiting, as well as the adaptation of treatment to jet-lag and all kind of physical activity are necessary to have a nice travel. Some specific aspects of travelling by car, boat or plane are discussed. PMID:15962625

Aebi, A; Golay, A

2005-05-11

46

Diabetes Experience Spring 2014 Interprofessional Diabetes Experience  

E-print Network

Diabetes Experience Spring 2014 Interprofessional Diabetes Experience Phar 6226/Nurs 5011 Spring the opportunity to learn in-depth knowledge of diabetes mellitus through active, hands-on learning experience of living with diabetes, in which they will give "insulin" injections and check blood glucoses

Thomas, David D.

47

Effects of Cottonseed Dietary Fiber on Metabolic Parameters in Diabetic Rats and Non-Insulin-Dependent Diabetic Humans1  

Microsoft Academic Search

The objective of this study was to evaluate the effect of gland cottonseed dietary fiber (CSDF) con taining 86% dietary fiber (mainly cellulose) on serum glu cose levels in diabetic rats and in non-insulin-dependent diabetes mellitus (NIDDM) patients. A diet containing 15% CSDF given to streptozotocin-induced diabetic rats for 30 d tended to reduce the postprandial plasma glucose level curve.

ZECHARIA MADAR; MICHAL NIR; Diabetic Unit Netania

48

Monogenic Diabetes  

MedlinePLUS

... diabetes. Instead, they are considered together, along with blood test results. Genetic testing A health care provider can best determine whether genetic testing is needed. Testing of the genetic information in a blood sample can determine whether a person has a ...

49

Tips for Teens with Diabetes: What Is Diabetes?  

MedlinePLUS

... NDEP Home > Teens > What is Diabetes? Tips for Teens with Diabetes: What is Diabetes? Download This Publication ( ... and for getting type 2 diabetes. Why do teens get diabetes? Both genes and things like viruses ...

50

Diabetes Health Concerns  

MedlinePLUS

... necessary screening tests. Top of Page How can diabetes affect cardiovascular health? Cardiovascular disease is the leading ... triglyceride, weight, and blood pressure problems related to diabetes? People with type 2 diabetes have high rates ...

51

Tuberculosis and Diabetes  

MedlinePLUS

TUBERCULOSIS & DIABETES COLLABORATIVE FRAMEWORK FOR CARE AND CONTROL OF TUBERCULOSIS AND DIABETES WHO Sept 2011 For more information: ... Recommended collaborative activities for prevention and care of diabetes and tuberculosis Indicators for evaluating collaborative activities Implementing collaborative activities ...

52

Weight and Diabetes  

MedlinePLUS

... a difference in a person's diabetes management plan. Weight and Type 1 Diabetes If a person has ... keep their blood sugar levels under control. Continue Weight and Type 2 Diabetes Most people are overweight ...

53

Diabetes - Foot Care  

MedlinePLUS Videos and Cool Tools

Diabetes - Foot Care Introduction People with diabetes are more likely than others to have problems with their feet. These problems can ... help prevent or delay foot complications. Daily Foot Care If you are a person with diabetes, checking ...

54

Diabetic hyperglycemic hyperosmolar syndrome  

MedlinePLUS

Diabetic hyperglycemic hyperosmolar syndrome (HHS) is a complication of type 2 diabetes . It involves extremely high blood ... Diabetic hyperglycemic hyperosmolar syndrome is a condition of: Extremely high blood sugar (glucose) level Extreme lack of ...

55

Diabetic Nerve Problems  

MedlinePLUS

... at the wrong times. This damage is called diabetic neuropathy. Over half of people with diabetes get ... you change positions quickly Your doctor will diagnose diabetic neuropathy with a physical exam and nerve tests. ...

56

Type 2 Diabetes Mellitus  

MedlinePLUS

... 35102, 69000, insulin,diabetes,type 2 diabetes,blood sugar,glucose,medication,heart,atherosclerosis,blood glucose,diet,high blood pressure,liver,cholesterol,digestion,exercise,kidney disease,obesity,retinopathy,aspirin,blindness,dehydration,diabetics,diarrhea

57

Diabetes and Dietary Supplements  

MedlinePLUS

... Kidney Diseases. Diabetes Overview . National Diabetes Information Clearinghouse Web site. Accessed at www.diabetes.niddk.nih.gov/dm/pubs/overview on January 15, 2013. Smith DM, Pickering RM, Lewith GT. A systematic review ...

58

Healthy Eating with Diabetes Video  

MedlinePLUS Videos and Cool Tools

... Eating with Diabetes Video Healthy Eating with Diabetes Video Making changes in the way you eat can ... Eating with Diabetes Transcript Healthy Eating with Diabetes Video (MP4) Keywords: self-management , healthy eating , National Diabetes ...

59

Diabetes Diagnosis  

NSDL National Science Digital Library

In this inquiry-based lesson, students learn about diabetes mellitus and explore techniques for diagnosing and monitoring the disease. Students must propose a plan for testing two different case study patients, then carry out their plan using artificial samples from each patient. This teaching resource was developed by a K-12 science teacher in the American Physiological Society?s 1999 Frontiers in Physiology Program. For more information on this program, please visit www.frontiersinphys.org.

Ms. Marcy Hotchkiss (Landsdowne High School)

1999-12-01

60

Diabetic Encephalopathy  

Microsoft Academic Search

Diabetes and its treatment are associated with functional and structural disturbances in the brain. Acute disturbances are\\u000a related to acute hypoglycemia or severe hyperglycemia and stroke. These acute metabolic and vascular insults to the brain\\u000a are well known and beyond the scope of this chapter, which will focus on changes in cerebral function and structure that develop\\u000a more insidiously. These

Geert Jan Biessels

61

Diabetic Neuropathies  

Microsoft Academic Search

Clinical trials of agents for the treatment of diabetic neuropathy have been confronted with a lack of agreement on appropriate\\u000a endpoints and have generated controversy on why ample demonstration of efficacy of an agent in animal studies has not been\\u000a readily translated into success in human clinical trials. There has been a failure to recognize that the relief of symptoms

Aaron I. Vinik

62

Oral Diabetes Drugs (Treating Type 2 Diabetes)  

MedlinePLUS

If You Have Type 2 Diabetes When you have diabetes, you have too much glucose, or sugar, in your blood. Th is can cause serious health problems, ... as heart disease, stroke, and blindness. People with diabetes who do not lower their blood sugar usually ...

63

Vanadium and diabetes  

Microsoft Academic Search

We demonstrated in 1985 that vanadium administered in the drinking water to streptozotocin (STZ) diabetic rats restored elevated blood glucose to normal. Subsequent studies have shown that vanadyl sulfate can lower elevated blood glucose, cholesterol and triglycerides in a variety of diabetic models including the STZ diabetic rat, the Zucker fatty rat and the Zucker diabetic fatty rat. Long-term studies

Patrick Poucheret; Subodh Verma; Marc D. Grynpas; John H. McNeill

1998-01-01

64

Diabetes and Pregnancy  

Microsoft Academic Search

Diabetes mellitus is the most common complication in pregnancy, affecting nearly 8% of all pregnancies. Nearly 90% of women\\u000a with diabetes develop the condition during pregnancy; diabetes in the other 10% antedated the pregnancy. Since the discovery\\u000a of insulin, perinatal mortality rates for women with diabetes have decreased, however, infant morbidity remains higher than\\u000a in the nondiabetes pregnant population.\\u000a \\u000a Diabetes

Alyce M. Thomas

65

Children and Diabetes: SEARCH for Diabetes in Youth  

MedlinePLUS

... Diabetes Public Health Resource Share Compartir Children and Diabetes On this Page SEARCH Facts Implications SEARCH Research Centers For More Information SEARCH Publications SEARCH for Diabetes in Youth Diabetes is one of the most ...

66

Diabetes and pancreatic cancer.  

PubMed

The relationship between diabetes and pancreatic cancer is complex. Diabetes or impaired glucose tolerance is present in more than 2/3rd of pancreatic cancer patients. Epidemiological studies have consistently shown a modest increase in the risk of pancreatic cancer in type 2 diabetes, with an inverse relationship to duration of disease. Additionally, recent studies suggest that anti-diabetic medications may modulate the risk of pancreatic cancer in type 2 diabetes. Subjects >50 years of age with new onset diabetes are at higher risk of having pancreatic cancer. However, to screen new-onset diabetes for pancreatic cancer, additional markers are needed that can distinguish pancreatic cancer-associated diabetes from type 2 diabetes. PMID:23207610

Muniraj, T; Chari, S T

2012-12-01

67

Diabetes and pancreatic cancer  

PubMed Central

The relationship between diabetes and pancreatic cancer is complex. Diabetes or impaired glucose tolerance is present in more than 2/3rd of pancreatic cancer patients. Epidemiological studies have consistently shown a modest increase in the risk of pancreatic cancer in type 2 diabetes, with an inverse relationship to duration of disease. Additionally, recent studies suggest that anti-diabetic medications may modulate the risk of pancreatic cancer in type 2 diabetes. Subjects >50 years of age with new onset diabetes are at higher risk of having pancreatic cancer. However, to screen new-onset diabetes for pancreatic cancer, additional markers are needed that can distinguish pancreatic cancer-associated diabetes from type 2 diabetes. PMID:23207610

MUNIRAJ, T.; CHARI, S. T.

2014-01-01

68

Diabetes: What's True and False?  

MedlinePLUS

... Body Works Main Page The Pink Locker Society Diabetes: What's True and False? KidsHealth > Kids > Diabetes Center > ... True or False: Eating Too Much Sugar Causes Diabetes False: When kids get type 1 diabetes , it's ...

69

"Control Your Diabetes. For Life."  

MedlinePLUS

... Javascript on. Feature: Diabetes "Control Your Diabetes. For Life." Past Issues / Fall 2009 Table of Contents For information about "Control Your Diabetes. For Life" campaign, visit www.YourDiabetesInfo.org or call toll- ...

70

Type 1 Diabetes: What Is It?  

MedlinePLUS

Type 1 Diabetes: What Is It? KidsHealth > Parents > Diabetes Center > Diabetes Basics > Type 1 Diabetes: What Is It? Print A A ... in learning to live with the disease. About Diabetes Diabetes is a disease that affects how the ...

71

Type 1 Diabetes: What Is It?  

MedlinePLUS

Type 1 Diabetes: What Is It? KidsHealth > Kids > Diabetes Center > What's Diabetes? > Type 1 Diabetes: What Is It? Print A A ... What is it? Let's find out. What Is Diabetes? Diabetes is a disease that affects how the ...

72

[Diabetes and hearing impairment due to mitochondrial mutation.  

PubMed

Mutations in the mitochondrial genome can cause mitochondrial diabetes. We present two cases in which the same mutation, mtDNA3243A>G, caused two different phenotypes: maternally inherited diabetes and deafness and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. Mitochondrial disease can imitate a variety of common con-ditions and should be considered in the case of multisystem disease, complex neurological symptoms or neurological symptoms combined with symptoms of other organ systems. PMID:25294200

Lauterlein, Jens-Jacob; Olsen, Inger; Yderstrde, Knud; Nielsen, Morten Frost

2014-09-15

73

Diabetes food pyramid (image)  

MedlinePLUS

The Diabetes Food Pyramid divides food into six groups, which vary in size to show relative amounts of servings for ... Guide Pyramid released by the USDA. In the Diabetes Food Pyramid, the groups are based on protein content ...

74

Epidemiology of diabetes  

PubMed Central

The disease burden related to diabetes is high and rising in every country, fuelled by the global rise in the prevalence of obesity and unhealthy lifestyles. The latest estimates show a global prevalence of 382 million people with diabetes in 2013, expected to rise to 592 million by 2035. The aetiological classification of diabetes has now been widely accepted. Type 1 and type 2 diabetes are the two main types, with type 2 diabetes accounting for the majority (>85%) of total diabetes prevalence. Both forms of diabetes can lead to multisystem complications of microvascular endpoints, including retinopathy, nephropathy and neuropathy, and macrovascular endpoints including ischaemic heart disease, stroke and peripheral vascular disease. The premature morbidity, mortality, reduced life expectancy and financial and other costs of diabetes make it an important public health condition.

Forouhi, Nita Gandhi; Wareham, Nicholas J.

2014-01-01

75

Diabetes Diagnosis Dilemma  

MedlinePLUS Videos and Cool Tools

... the lower right-hand corner of the player. Diabetes Diagnosis Dilemma HealthDay November 18, 2014 Related MedlinePlus Pages Diabetes Health Screening Transcript Approximately three out of every ...

76

Staying Healthy with Diabetes  

MedlinePLUS

... Public Health Resource Share Compartir Staying Healthy with Diabetes On this Page What routine medical examinations and ... examinations and tests are needed for people with diabetes? Your doctors should Measure your blood pressure at ...

77

Diabetes and Celiac Disease  

MedlinePLUS

... in every 133 people in the United States. Diabetes and celiac disease: The link There is a ... blood sugar control. Signs of a malabsorption problem Diabetes Celiac Disease Weight Loss X X GI symptoms ( ...

78

Cardiovascular Disease and Diabetes  

MedlinePLUS

Cardiovascular Disease & Diabetes Updated:Jan 31,2013 The following statistics speak loud and clear that there is a strong correlation between cardiovascular disease (CVD) and diabetes. Heart diseases and stroke are ...

79

Diabetic Kidney Problems  

MedlinePLUS

... too high. Over time, this can damage your kidneys. Your kidneys clean your blood. If they are damaged, waste ... in your blood instead of leaving your body. Kidney damage from diabetes is called diabetic nephropathy. It ...

80

Diabetes and Memory  

MedlinePLUS Videos and Cool Tools

... right-hand corner of the player. Diabetes and Memory HealthDay December 2, 2014 Related MedlinePlus Pages Diabetes Exercise and Physical Fitness Memory Nutrition Transcript Another big reason to eat healthy ...

81

Diabetic Ulcer (Neurogenic Ulcer)  

MedlinePLUS

newsletter | contact Share | Diabetic Ulcer (Neurogenic Ulcer) Information for adults A A A A neurogenic ulcer begins with thickening and a callus on ... the right. Overview Neurogenic ulcers, also known as diabetic ulcers, are ulcers that occur most commonly on ...

82

Diabetic Eye Disease  

MedlinePLUS

... de los Ojos Cmo hablarle a su oculista Diabetic Eye Disease Listen View this module and educate yourself, family, and friends about diabetic eye disease. This module includes descriptive audio and ...

83

Diabetes and Insulin  

MedlinePLUS

... and preventing hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose), they may reduce the risk of diabetic health ... monitor your blood glucose to avoid high or low blood glucose. You can manage your diabetes with diet, exercise, ...

84

Have Diabetes. Will Travel.  

MedlinePLUS

Have Diabetes. Will Travel. By the National Diabetes Education Program Heading out of town? Leaving your troubles behind? Off on an ... not stop you from traveling in style, you will need to do some careful planning. Here are ...

85

Air Travel and Diabetes  

MedlinePLUS

... diabetes. We work with the Transportation Security Administration (TSA) to ensure that passengers with diabetes have access ... difficulties so that we can provide feedback to TSA. If, at the end of your travels, you ...

86

Diabetes Movie (For Parents)  

MedlinePLUS Videos and Cool Tools

... Crisp Choosing Safe Toys Checkups: What to Expect Ebola: What to Know Diabetes Movie KidsHealth > Parents > Diabetes ... purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor. 1995- The Nemours Foundation. All ...

87

Diabetes and Cardiovascular Disease  

Microsoft Academic Search

Diabetes has been shown to be increasing at a rapid rate in the United States. There estimates of 23.6 million individuals with diabetes with 1.6 million new cases being diagnosed annually. [1] Diabetes has long been known as a risk factor for the development of cardiovascular disease. Experts indicate 38% of patients admitted to the hospital are diabetic.[2] Therefore one

Barbara Bobbi Leeper; Dl Mcgee

1979-01-01

88

[Prokinetics and diabetes mellitus].  

PubMed

Dyspeptic upper gastrointestinal symptoms and delayed gastric emptying occur frequently in patients with diabetes mellitus. Prokinetics are drugs which are used in medical treatment of motility disorders in patients with diabetes. Itopride hydrochloride is the optimal drug for the therapy of motility disorders in diabetics. PMID:15305632

Keil, R

2004-05-01

89

Kidney Disease of Diabetes  

E-print Network

Kidney Disease of Diabetes National Kidney and Urologic Diseases Information Clearinghouse is the final stage of chronic kidney disease (CKD). Diabetes is the most common cause of kidney failure, accounting for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD

Baker, Chris I.

90

Diabetes Type 2  

MedlinePLUS

Diabetes means your blood glucose, or blood sugar, levels are too high. With type 2 diabetes, the more common type, your body does not ... You have a higher risk of type 2 diabetes if you are older, obese, have a family ...

91

the Student with Diabetes  

E-print Network

Helping the Student with Diabetes Succeed AGuide for School Personnel Updated Edition 2010 U for Disease Control and Prevention #12;ii www.YourDiabetesInfo.org Supporting Organizations This guide was produced by the National Diabetes Education Program (NDEP), a federally sponsored partnership

Rau, Don C.

92

Psychosocial aspects of diabetes  

Microsoft Academic Search

This article discusses the dilemmas that patients and health care professionals face as they attempt to deal with the psychologic issues inherent in diabetes care. It includes discussions of assessment of psychosocial functioning; type I and type II diabetes assess ment ; adherence and motivation; empowerment; and specific recommendations geared to help health care professionals care for the diabetic patient

Joseph B. Nelson

1992-01-01

93

The Student with Diabetes.  

ERIC Educational Resources Information Center

Since nearly one million students suffer from diabetes, most teachers are likely to have a diabetic child in class at some time. Though most diabetic children are not likely to require an insulin injection during the day, it is necessary that every teacher be aware of the occasional problems which might arise. (JN)

Wentworth, Samuel M.; Hoover, Joan

1981-01-01

94

Diabetes and Hispanic Americans  

MedlinePLUS

... prev/national/menuage.htm Age-adjusted percentage of visual impairment per 100 adults with diabetes (2011) Hispanics/Latinos White Hispanic/ White Ratio Men and Women 15.6 17.1 0.9 ... Diabetes Surveillance System. http://www.cdc.gov/diabetes/statistics/visual/fig5.htm Rate of initiation of treatment for ...

95

Diabetes Reunion Celebrating Sensibly with Diabetes  

E-print Network

of food at each meal. If the meal includes reasonable amounts of starches, fiber and sugar, even people with diabetes may enjoy a small dessert. We also learned that we can reduce the sugar in certain recipes and modify recipes with noncaloric sweeteners to prepare desserts that fit into diabetes meal plans

96

Year in Diabetes 2012: The Diabetes Tsunami  

PubMed Central

Diabetes affects more than 300 million individuals globally, contributing to significant morbidity and mortality worldwide. As the incidence and prevalence of diabetes continue to escalate with the force of an approaching tsunami, it is imperative that we better define the biological mechanisms causing both obesity and diabetes and identify optimal prevention and treatment strategies that will enable a healthier environment and calmer waters. New guidelines from the American Diabetes Association/European Association of the Study of Diabetes and The Endocrine Society encourage individualized care for each patient with diabetes, both in the outpatient and inpatient setting. Recent data suggest that restoration of normal glucose metabolism in people with prediabetes may delay progression to type 2 diabetes (T2DM). However, several large clinical trials have underscored the limitations of current treatment options once T2DM has developed, particularly in obese children with the disease. Prospects for reversing new-onset type 1 diabetes also appear limited, although recent clinical trials indicate that immunotherapy can delay the loss of ?-cell function, suggesting potential benefits if treatment is initiated earlier. Research demonstrating a role for the central nervous system in the development of obesity and T2DM, the identification of a new hormone that simulates some of the benefits of exercise, and the development of new ?-cell imaging techniques may provide novel therapeutic targets and biomarkers of early diabetes detection for optimization of interventions. Today's message is that a diabetes tsunami is imminent, and the only way to minimize the damage is to create an early warning system and improve interventions to protect those in its path. PMID:23185035

Jastreboff, A. M.

2012-01-01

97

Built environment and diabetes  

PubMed Central

Development of type 2 diabetes mellitus is influenced by built environment, which is, the environments that are modified by humans, including homes, schools, workplaces, highways, urban sprawls, accessibility to amenities, leisure, and pollution. Built environment contributes to diabetes through access to physical activity and through stress, by affecting the sleep cycle. With globalization, there is a possibility that western environmental models may be replicated in developing countries such as India, where the underlying genetic predisposition makes them particularly susceptible to diabetes. Here we review published information on the relationship between built environment and diabetes, so that appropriate modifications can be incorporated to reduce the risk of developing diabetes mellitus. PMID:20535308

Pasala, Sudhir Kumar; Rao, Allam Appa; Sridhar, G. R.

2010-01-01

98

Survival Benefit of Nephrologic Care in Patients With Diabetes Mellitus and Chronic Kidney Disease  

Microsoft Academic Search

Background: The association of nephrologic care and survival in patients with diabetes mellitus and chronic kidney disease is unknown. Methods: Using data from 1997 to 2000, we con- ducted a retrospective cohort study of Veterans Health Administration clinic users having diabetes mellitus and stage 3 or 4 chronic kidney disease. The baseline period was 12 months and median follow-up was

Chin-Lin Tseng; Elizabeth F. O. Kern; Donald R. Miller; Anjali Tiwari; Miriam Maney; Mangala Rajan; Leonard Pogach

2008-01-01

99

Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment1-3  

Microsoft Academic Search

Background: Type 2 diabetes is an epidemic that is affecting an ever-increasing proportion of the US population. Although con- sumption of refined carbohydrates has increased and is thought to be related to the increased risk of type 2 diabetes, the ecologic effect of changes in the quality of carbohydrates in the food supply on the risk of type 2 diabetes

Lee S Gross; Earl S Ford; Simin Liu

100

The Diabetic Foot  

PubMed Central

The diabetic foot presents a complex interplay of neuropathic, macrovascular, and microvascular disease on an abnormal metabolic background, complicated by an increased susceptibility to mechanical, thermal, and chemical injury and decreased healing ability. The abnormalities of diabetes, once present, are not curable. But most severe foot abnormalities in the diabetic are due to neglect of injury and are mostly preventable. The physician must ensure that the diabetic patient learns the principles of good foot care. If time for teaching is limited, this task must be delegated to a podiatrist or a diabetes nurse educator in a diabetes day centre. It is the physician's responsibility to confirm foot care by personal inspection of the feet of all diabetic patients at every visit. PMID:21234002

Hunt, J.A.

1990-01-01

101

Harold Schnitzer Diabetes Health Center Type 1 Diabetes  

E-print Network

Harold Schnitzer Diabetes Health Center Type 1 Diabetes Support Group Our support group is dedicated to adults of all ages (16 years and older) with type 1 diabetes. Each month most our time Schnitzer Diabetes Health Center will also present a short diabetes-related topic to get the discussion

Chapman, Michael S.

102

Harold Schnitzer Diabetes Health Center Type 1 Diabetes  

E-print Network

Harold Schnitzer Diabetes Health Center Type 1 Diabetes Support Group 2014 Our support group is dedicated to adults of all ages (16 years and older) with type 1 diabetes. Each month most our time Schnitzer Diabetes Health Center will also present a short diabetes-related topic to get the discussion

Chapman, Michael S.

103

Harold Schnitzer Diabetes Health Center Type 1 Diabetes Support Group  

E-print Network

Harold Schnitzer Diabetes Health Center Type 1 Diabetes Support Group Our support group is dedicated to adults of all ages (16 years and older) with type 1 diabetes. Each month most our time will be for sharing and a professional from our diabetes center will present a short diabetes-related topic

Chapman, Michael S.

104

Skin lesions in diabetic patients  

Microsoft Academic Search

Objective It is yet unknown the relationship between diabetes and determinants or triggering factors of skin lesions in diabetic patients. The purpose of the present study was to investigate the presence of unreported skin lesions in diabetic patients and their relationship with metabolic control of diabetes. Methods A total of 403 diabetic patients, 31% type 1 and 69% type 2,

N T Foss; D P Polon; M H Takada; M C Foss-Freitas; M C Foss

105

Diabetes and Pancreatic Cancer  

PubMed Central

Type 2 diabetes mellitus is likely the third modifiable risk factor for pancreatic cancer after cigarette smoking and obesity. Epidemiological investigations have found that long-term type 2 diabetes mellitus is associated with a 1.5- to 2.0-fold increase in the risk of pancreatic cancer. A causal relationship between diabetes and pancreatic cancer is also supported by findings from prediagnostic evaluations of glucose and insulin levels in prospective studies. Insulin resistance and associated hyperglycemia, hyperinsulinemia, and inflammation have been suggested to be the underlying mechanisms contributing to development of diabetes-associated pancreatic cancer. Signaling pathways that regulate the metabolic process also play important roles in cell proliferation and tumor growth. Use of the antidiabetic drug metformin has been associated with reduced risk of pancreatic cancer in diabetics and recognized as an antitumor agent with the potential to prevent and treat this cancer. On the other hand, new-onset diabetes may indicate subclinical pancreatic cancer, and patients with new-onset diabetes may constitute a population in whom pancreatic cancer can be detected early. Biomarkers that help define high-risk individuals for clinical screening for pancreatic cancer are urgently needed. Why pancreatic cancer causes diabetes and how diabetes affects the clinical outcome of pancreatic cancer have yet to be fully determined. Improved understanding of the pathological mechanisms shared by diabetes and pancreatic cancer would be the key to the development of novel preventive and therapeutic strategies for this cancer. PMID:22162232

Li, Donghui

2011-01-01

106

Tips for Teens with Diabetes: What Is Diabetes?  

MedlinePLUS

... In type 1 diabetes, the cells in the pancreas that make insulin are destroyed. If you have ... or juvenile diabetes. In type 2 diabetes , the pancreas still makes some insulin but cells cannot use ...

107

Diabetes Mellitus 1.-Qu es la Diabetes Mellitus?  

E-print Network

Diabetes Mellitus 1.- ¿Qué es la Diabetes Mellitus? La diabetes mellitus es un trastorno metabólico necesaria para desarrollar cualquier tipo de trabajo. La causa de la diabetes es una anomalía en la glucosuria 3.- ¿Cómo se detecta la Diabetes? El estudio de diabetes se realiza mediante la medición de la

Escolano, Francisco

108

Diabetes: What's True and False?  

MedlinePLUS

... which are false. Eating too much sugar causes diabetes. False: Type 1 diabetes happens when the cells ... person's risk for developing the disease. People with diabetes can never eat sweets. False: You can have ...

109

Weight and Diabetes (For Parents)  

MedlinePLUS

... who have type 1 or type 2 diabetes. Weight and Type 1 Diabetes Undiagnosed or untreated, type ... can have trouble controlling their blood sugar levels . Weight and Type 2 Diabetes Most people are overweight ...

110

Diabetes Control: Why It's Important  

MedlinePLUS

... Works Main Page The Pink Locker Society Diabetes Control: Why It's Important KidsHealth > Kids > Diabetes Center > Medication ... Causes Blood Sugar Levels to Be Out of Control? Managing diabetes is like a three-way balancing ...

111

DIABETES, OBESITY AND METABOLISM INSTITUTE  

E-print Network

DIABETES, OBESITY AND METABOLISM INSTITUTE AT NORTHWESTERN MEDICINE THE INSTITUTES AT NORTHWESTERN MEDICINE #12;THE INSTITUTES AT NORTHWESTERN MEDICINE DIABETES, OBESITY AND METABOLISM INSTITUTE AT NORTHWESTERN MEDICINE "As we launch the Diabetes, Obesity and Metabolism Institute at Northwestern Medicine, I

Engman, David M.

112

Silymarin and diabetic nephropathy  

PubMed Central

Nephropathy is one of the most important complications of diabetes mellitus and drug induced toxicity. Nephrotoxicity is mostly related to oxidative stress and nowadays much attention has been made towards the possible kidney protective properties of medicinal plants. Studies revealed, silymarin is useful for diabetic nephropathy. The combination of metformin, silymarin and renin-angiotensin system inhibitors or angiotensin receptor blockers may have additive kidney protective property to prevent or slowing the progression of diabetic nephropathy. PMID:25340091

Rafieian-Kopaie, Mahmoud; Nasri, Hamid

2012-01-01

113

Diabetes and Sexual Health  

Microsoft Academic Search

Diabetes is a complex disease that affects both men and women, resulting in a myriad of physical and psychological conditions.\\u000a Sexual dysfunction is a common, devastating complication of diabetes that significantly impacts quality of life, and as such\\u000a must be addressed and treated. The most common complications in men with diabetes are erectile dysfunction, low testosterone,\\u000a and premature ejaculation. Women

Donna Rice; Janis Roszler; Jo Anne B. Farrell

114

Diabetic fibrous mastopathy.  

PubMed

Diabetic fibrous mastopathy is an uncommon self-limiting fibroinflammatory diseae of the breast that is seen predominantly in premenopausal women with long standing type I (insulin dependent) diabetes mellitus. In this report, we present a 29 years old female with uncontrolled diabetes mellitus presenting with bilateral breast masses which were irregular and hypoechoic on ultrasound, gradual enhancement on MRI and diagnosed as diabetic fibrous mastopathy on histopathology. It is quite difficult to distinguish it from malignancy on mammographic and ultrasonographic features or clinical findings. Correlation of the pathological features may help to make the correct diagnosis for this disease. PMID:24717992

Gunduz, Yasemin; Tatli, Lacin; Kara, Rabia Oztas; Cakar, Gozde Cakirsoy; Akdemir, Nermin; Dilek, Fatma Hsniye

2014-03-01

115

[Diabetic foot osteomyelitis].  

PubMed

Bone and joint infections associated with chronic wound of the diabetic foot are frequent and severe complications that should be considered in most cases. Early diagnosis and aggressive treatment are likely to limit bad outcome. Clinical studies with acceptable methodology addressing the relative role of medical and surgical approaches are needed. Bone biopsy available in routine in a diabetic foot clinic represents a marker of good quality of management of such patients. Given the global burden and potential severity of osteomyelitis of the diabetic foot, every measure that can prevent the occurrence and persistence of a foot wound in a diabetic patient remain major objectives. PMID:17695679

Senneville, Eric

2007-05-15

116

The Heart in Diabetes  

PubMed Central

Since the introduction of insulin, heart disease has become a major impediment to survival in persons with diabetes mellitus. Coronary disease has increased severity and accelerated development in diabetic persons compared with an age- and sex-matched nondiabetic population. A peculiar vulnerability of women to the influence of diabetes with loss of premenopausal coronary disease protection has been found. The symptomatology of coronary events may differ and coronary care data show a higher incidence of sudden death in diabetic patients who have a myocardial infarction than in their non-diabetic counterparts. Insulin may play a role in the myocardial adjustment to an ischemic insult by enhancing glucose intake and suppressing lipolysis and ketogenesis. Carbohydrate intolerance in dogs, rhesus monkeys and humans appears associated with similar histologic and compositional changes in the myocardium. Abnormalities in diastolic ventricular function not attributable to large- or small-vessel coronary disease have been found in the diabetic subjects of each species. Studies in humans who have diabetes have assessed single pressure-volume relationships and more exacting measures of ventricular compliance are needed. Abnormalities of myocardial function in patients with diabetes have been found using echo and radionuclide techniques. Many of these findings need to be correlated with invasive data or confirmed in larger populations. Autonomic dysfunction is common in diabetic persons and may imply an associated poor prognosis. Reflex abnormalities in parasympathetic function are most prevalent and occur before sympathetic dysfunction. PMID:6372249

Kereiakes, Dean J.; Naughton, James L.; Brundage, Bruce; Schiller, Nelson B.

1984-01-01

117

Discrimination (Based on Diabetes)  

MedlinePLUS

... ending this discrimination through our legal advocacy program. Commercial Driver's License Information on special rules that apply to commercial drivers with diabetes. The Steve Bieringer Award The ...

118

Painful diabetic neuropathy.  

PubMed

Diabetes is a worldwide epidemic, and associated neuropathy is its most costly and disabling complication. Given the rising prevalence of painful diabetic neuropathy, it is increasingly important that we understand the best ways to diagnose and treat this condition. Diagnostic tests in this field are evolving rapidly. These include the use of skin biopsies to measure small unmyelinated fibers, as well as even newer techniques that can measure both small unmyelinated fibers and large myelinated fibers in the same biopsy. The main treatments for painful diabetic neuropathy remain management of the underlying diabetes and drugs for the relief of pain. However, emerging evidence points to major differences between type 1 and type 2 diabetes, including the ability of glycemic control to prevent neuropathy. Enhanced glucose control is much more effective at preventing neuropathy in patients with type 1 diabetes than in those with type 2 disease [corrected]. This dichotomy emphasizes the need to study the pathophysiologic differences between the two types of diabetes, because different treatments may be needed for each condition. The impact of the metabolic syndrome on neuropathy in patients with type 2 diabetes may account for the difference between the two types of diabetes and requires further study. Finally, neuropathic pain is under-recognized and undertreated despite an ever evolving list of effective drugs. Evidence exists to support several drugs, but the optimal sequence and combination of these drugs are still to be determined. PMID:24803311

Peltier, Amanda; Goutman, Stephen A; Callaghan, Brian C

2014-01-01

119

Winter depression and diabetes.  

PubMed

Depression is a common and often harmful disorder, which is frequently associated with the winter season. Research has shown a link between type 2 diabetes mellitus and depression. Furthermore, diabetics with depression have a higher rate of adverse outcomes. Little has been published regarding the seasonality of depression in diabetics. The case report described in this article concerns a 65-year-old woman with type 2 diabetes and a history of winter depression. Current evidence-based management options are reviewed. PMID:23089656

Ernst, Christine R

2012-12-01

120

Diabetic Retinopathy: Nature and Extent.  

ERIC Educational Resources Information Center

The authors discuss the incidence and prevalence of diabetic retinopathy in juvenile and maturity onset diabetics, background and proliferative retinopathy, and current modalities of treatment. (Author)

Coughlin, W. Ronald; Patz, Arnall

1978-01-01

121

Monogenic Forms of Diabetes: Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young  

MedlinePLUS

... neonatal diabetes mellitus. New England Journal of Medicine . 2006;355(5):456-466. Colombo C, Delvecchio M, ... and Adolescent Diabetes (ISPAD) Clinical Practice Consensus Guidelines 2006-2007. Definition, epidemiology and classification. Pediatric Diabetes . 2006; ...

122

Nephrogenic Diabetes Insipidus  

NSDL National Science Digital Library

Physiology in Medicine review article. This articles describes how a patient gets diabetes insipidus, the effects of this disease on a patient, and the therapy to control this disease. This article also describes vasopressin, aquaporins, and the Bartter system, and their relationships with diabetes insipidus.

MD Jeff M Sands (Emory Univ Sch Med Dept Med, Renal Div)

2006-02-13

123

Diabetes mellitus prevention.  

PubMed

The aim of this study was to review lifestyle modification interventions and pharmacological clinical studies designed to prevent diabetes and provide evidence-based recommendations for the prevention of Diabetes Mellitus. A review of relevant literature compiled via a literature search (PUBMED) of English-language publications between 1997 and 2010 was conducted. It is found that people at increased risk of developing type 2 diabetes mellitus can halt the development of the disease. Lifestyle modification intervention with reduction of 5%-10% of excess body weight and increase in moderate physical activity by 150 min/wk has consistently proven to reduce the appearance of diabetes in different at-risk populations. Pharmacologic interventions have also demonstrated the prevention of the appearance of diabetes in persons at risk. Bariatric surgery has decreased the appearance of diabetes patients in a select group of individuals. The progression from prediabetes to diabetes mellitus can be prevented. Lifestyle modification intervention changes with weight loss and increased physical activity are currently recommended for the prevention of diabetes. PMID:22020084

Allende-Vigo, Myriam Zaydee

2015-01-01

124

Dyslipidemia and Diabetic Retinopathy  

PubMed Central

Diabetic retinopathy (DR) is one of the major microvascular complications of diabetes. In developed countries, it is the most common cause of preventable blindness in diabetic adults. Dyslipidemia, a major systemic disorder, is one of the most important risk factors for cardiovascular disease. Patients with diabetes have an increased risk of suffering from dyslipidemia concurrently. The aim of this article is to review the association between diabetic retinopathy (DR) and traditional/nontraditional lipid markers, possible mechanisms involving lipid metabolism and diabetic retinopathy, and the effect of lipid-lowering therapies on diabetic retinopathy. For traditional lipid markers, evidence is available that total cholesterol and low-density lipoprotein cholesterol are associated with the presence of hard exudates in patients with DR. The study of nontraditional lipid markers is advancing only in recently years. The severity of DR is inversely associated with apolipoprotein A1 (ApoA1), whereas ApoB and the ApoB-to-ApoA1 ratio are positively associated with DR. The role of lipid-lowering medication is to work as adjunctive therapy for better control of diabetes-related complications including DR. PMID:24380088

Chang, Yo-Chen; Wu, Wen-Chuan

2013-01-01

125

Diabetes and Kidney Disease  

MedlinePLUS

... of high blood pressure and kidney disease. Maintaining control of your diabetes can lower your risk of developing severe kidney disease. What are the late signs of kidney disease in patients with diabetes? As your kidneys fail, your blood urea nitrogen (BUN) levels will rise as well as the ...

126

Help Teens Manage Diabetes  

MedlinePLUS

... Grey, dean of the Yale University School of Nursing, developed and tested a program called Coping Skills Training (CST) as a part of routine diabetes management. Its aim is to improve diabetic teens' coping and communication skills, healthy behaviors, and conflict resolution. The CST ...

127

Diabetes Treatment Breakthrough.  

ERIC Educational Resources Information Center

Eight experts in visual impairment respond briefly to reports that intensive monitoring of blood glucose levels by persons with diabetes can lead to a 70% reduction in the progression of detectable diabetic retinopathy. Comments are generally optimistic, though some cautions are raised. (DB)

Baker, Shelly; And Others

1993-01-01

128

Diabetic neuralgic amyotrophy  

PubMed Central

A rare neurological condition, neuralgic amyotrophy, in a diabetic is reported. Strong evidence for a causal relationship is suggested. Comment is made on striking similarities between the clinical presentation and course of both diabetic and neuralgic amyotrophy, inferring a similar end pathological process. ImagesFig. 1 PMID:7312743

Williams, Alan J.

1981-01-01

129

Glycemic Index and Diabetes  

MedlinePLUS

... Diabetes Forecast magazine: wcie-carbs, In this section Food What Can I Eat Understanding Carbohydrates Types of Carbohydrates Carbohydrate Counting Make Your Carbs Count Glycemic Index and Diabetes Sugar and Desserts Sugar Alcohols Low-Calorie Sweeteners donate en -- Acknowledge ...

130

Gestational Diabetes and Testing  

MedlinePLUS

... a healthy baby. You can! Journal of Midwifery & Womens Health www.jmwh.org 135 2006 by the American ... E S FOR MORE INFORMATION ABOUT GESTATIONAL DIABETES National Womens Health Information Center Diabetes http://www.4woman.gov/faq/ ...

131

Gestational Diabetes and Pregnancy  

MedlinePLUS

... Blood Pressure (Preeclampsia) When a pregnant woman has high blood pressure, protein in her urine, and often swelling in fingers ... during labor and delivery. Women with diabetes have high blood pressure more often than women without ... Low Blood Sugar (Hypoglycemia) People with diabetes who take ...

132

Diabetes Technologies and Their Role in Diabetes Management  

ERIC Educational Resources Information Center

The 1993 Diabetes Complications and Control Trial (DCCT) showed that controlling blood glucose prevents and delays the progression of long term complications of diabetes. New diabetes technologies can make control of diabetes possible and safer. This paper reviews these technologies used to monitor blood glucose, administer insulin and evaluate

Kollipara, Sobha; Silverstein, Janet H.; Marschilok, Katie

2009-01-01

133

Protect Your Heart Against Diabetes  

E-print Network

Protect Your Heart Against Diabetes Healthy Hearts, Healthy Homes #12;Read other booklets at www.nhlbi.nih.gov. #12;Protect Your Heart Against Diabetes Delicious Heart Healthy Latino Recipes #12;Protect Your Heart Against Diabetes 1 Did you know that type 2 diabetes is a serious problem

Bandettini, Peter A.

134

Cerebral function in diabetes mellitus  

Microsoft Academic Search

SummaryDiabetes mellitus is a common metabolic disorder associated with chronic complications such as nephropathy, angiopathy, retinopathy and peripheral neuropathy. Diabetes is not often considered to have deleterious effects on the brain. However, long-term diabetes results in a variety of subtle cerebral disorders, which occur more frequently than is commonly believed. Diabetic cerebral disorders have been demonstrated at a neurochemical, electrophysiological,

G. J. Biessels; A. C. Kappelle; B. Bravenboer; D. W. Erkelens; W. H. Gispen

1994-01-01

135

Contraception and the Adolescent Diabetic.  

ERIC Educational Resources Information Center

Data from a study of 11 teenage diabetics suggests that pregnancy among adolescent diabetics is more frequent than among the general population, at a time when diabetic control is poor because of psychosocial factors associated with adolescence. Current recommendations regarding contraception for diabetic women, focusing on barrier methods, are

Fennoy, Ilene

1989-01-01

136

DIABETES and METABOLIC SYNDROME PROGRAM  

Microsoft Academic Search

NETWORK DIABETES PROGRAM (NDP): The Division has developed and is responsible for a comprehensive diabetes program for the Cook County Bureau of Health Services . This includes 3 acute care hospital and 30 ambulatory sites for an estimated population of 30,000 patients with diabetes. The basis of the program are multidisciplinary diabetes teams operating in several sites throughout the Cook

Leon Fogelfeld; Ambika Babu; Rasa Kazlauskaite; Evelyn Lacuesta; Susana Mascarell

137

Las personas con diabetes deben lograr un balance entre los  

E-print Network

en un lado del plato y los alimentos bajos en carbohidratos al otro lado. Karen Halderson, MPH, RD bajos en carbohidratos, manteniendo cada uno en su propio lado del plato o de la mesa. Comer vegetales en diferentes lados de su plato y ver si su plato está "balanceado". Sin embargo, muchas veces

138

The vulnerable myocardium. Diabetic cardiomyopathy.  

PubMed

Cardiovascular disease is the major cause of morbidity and mortality in subjects suffering from diabetes mellitus. While coronary artery disease is the leading cause of cardiac complications in diabetics, it is widely recognized that diabetes increases the risk for the development of heart failure independently of coronary heart disease and hypertension. This increased susceptibility of the diabetic heart to develop structural and functional impairment is termed diabetic cardiomyopathy. The number of different mechanisms proposed to contribute to diabetic cardiomyopathy is steadily increasing and underlines the complexity of this cardiac entity. In this review the mechanisms that account for the increased myocardial vulnerability in diabetic cardiomyopathy are discussed. PMID:25408270

Bugger, H; Bode, C

2015-02-10

139

Non-Proliferative Diabetic Retinopathy Vision Simulator  

MedlinePLUS

... Sun Eye Health News Consumer Alerts Non-Proliferative Diabetic Retinopathy Vision Simulator Tweet How does non-proliferative diabetic retinopathy affect your vision? Nonproliferative diabetic retinopathy, also ...

140

Alcoholism and Diabetes Mellitus  

PubMed Central

Chronic use of alcohol is considered to be a potential risk factor for the incidence of type 2 diabetes mellitus (T2DM), which causes insulin resistance and pancreatic ?-cell dysfunction that is a prerequisite for the development of diabetes. However, alcohol consumption in diabetes has been controversial and more detailed information on the diabetogenic impact of alcohol seems warranted. Diabetes, especially T2DM, causes dysregulation of various metabolic processes, which includes a defect in the insulin-mediated glucose function of adipocytes, and an impaired insulin action in the liver. In addition, neurobiological profiles of alcoholism are linked to the effects of a disruption of glucose homeostasis and of insulin resistance, which are affected by altered appetite that regulates the peptides and neurotrophic factors. Since conditions, which precede the onset of diabetes that are associated with alcoholism is one of the crucial public problems, researches in efforts to prevent and treat diabetes with alcohol dependence, receives special clinical interest. Therefore, the purpose of this mini-review is to provide the recent progress and current theories in the interplay between alcoholism and diabetes. Further, the purpose of this study also includes summarizing the pathophysiological mechanisms in the neurobiology of alcoholism. PMID:22540046

Kim, Soo-Jeong

2012-01-01

141

Diabetes Health Disparities  

PubMed Central

Racial and ethnic minorities bear a disproportionate burden of the diabetes epidemic; they have higher prevalence rates, worse diabetes control, and higher rates of complications. This article reviews the effectiveness of health care interventions at improving health outcomes and/or reducing diabetes health disparities among racial/ethnic minorities with diabetes. Forty-two studies met inclusion criteria. On average, these health care interventions improved the quality of care for racial/ethnic minorities, improved health outcomes (such as diabetes control and reduced diabetes complications), and possibly reduced health disparities in quality of care. There is evidence supporting the use of interventions that target patients (primarily through culturally tailored programs), providers (especially through one-on-one feedback and education), and health systems (particularly with nurse case managers and nurse clinicians). More research is needed in the areas of racial/ethnic minorities other than African Americans and Latinos, health disparity reductions, long-term diabetes-related outcomes, and the sustainability of health care interventions over time. PMID:17881626

Peek, Monica E.; Cargill, Algernon; Huang, Elbert S.

2008-01-01

142

Current Concepts in Diabetic Retinopathy  

PubMed Central

For the past several decades, tremendous efforts have been made to decrease the complications of diabetes, including diabetic retinopathy. New diagnostic modalities like ultrawide field fundus fluorescein angiography and spectral domain optical coherence tomography has allowed more accurate diagnosis of early diabetic retinopathy and diabetic macular edema. Antivascular endothelial growth factors are now extensively used to treat diabetic retinopathy and macular edema with promising results. There remains uncertainty over the long term effects and the socioeconomic costs of these agents. PMID:25541604

Song, Su Jeong

2014-01-01

143

Diabetic angiopathy and angiogenic defects  

PubMed Central

Diabetes is one of the most serious health problems in the world. A major complication of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. In this review, we focus on angiogenesis abnormalities in diabetic complications and discuss its benefits and drawbacks as a therapeutic target for diabetic vascular complications. Additionally, we discuss glucose metabolism defects that are associated with abnormal angiogenesis in atypical diabetic complications such as cancer. PMID:22853690

2012-01-01

144

Resource use among patients with diabetes, diabetic neuropathy, or diabetes with depression  

Microsoft Academic Search

BACKGROUND: Diabetes is often associated with complications and comorbidities. The purpose of this research is to compare medical resources used by patients with the following diagnoses: diabetes mellitus (DM), diabetic neuropathy (DN), and diabetes mellitus combined with comorbid depression (DD). METHODS: Adult patients who were diagnosed with DM, DN, or DD were included in the study. There were 55,972 patients

Trong K Le; Stephen L Able; Maureen J Lage

2006-01-01

145

Diabetes in South Asians.  

PubMed

Economic, dietary and other lifestyle transitions have been occurring rapidly in most South Asian countries, making their populations more vulnerable to developing Type 2 diabetes and cardiovascular diseases. Recent data show an increasing prevalence of Type 2 diabetes in urban areas as well as in semi-urban and rural areas, inclusive of people belonging to middle and low socio-economic strata. Prime determinants for Type 2 diabetes in South Asians include physical inactivity, imbalanced diets, abdominal obesity, excess hepatic fat and, possibly, adverse perinatal and early life nutrition and intra-country migration. It is reported that Type 2 diabetes affects South Asians a decade earlier and some complications, for example nephropathy, are more prevalent and progressive than in other races. Further, prevalence of pre-diabetes is high, and so is conversion to diabetes, while more than 50% of those who are affected remain undiagnosed. Attitudes, cultural differences and religious and social beliefs pose barriers in effective prevention and management of Type 2 diabetes in South Asians. Inadequate resources, insufficient healthcare budgets, lack of medical reimbursement and socio-economic factors contribute to the cost of diabetes management. The challenge is to develop new translational strategies, which are pragmatic, cost-effective and scalable and can be adopted by the South Asian countries with limited resources. The key areas that need focus are: generation of awareness, prioritizing health care for vulnerable subgroups (children, women, pregnant women and the underprivileged), screening of high-risk groups, maximum coverage of the population with essential medicines, and strengthening primary care. An effective national diabetes control programme in each South Asian country should be formulated, with these issues in mind. PMID:24975549

Misra, A; Ramchandran, A; Jayawardena, R; Shrivastava, U; Snehalatha, C

2014-10-01

146

Obesity and diabetes.  

PubMed

Type 2 diabetes mellitus is characterized by hyperglycemia, insulin resistance, and relative impairment in insulin secretion and its possible long term complications. Its pathogenesis is poorly understood, but both genetic and environmental factors, such as obesity and aging, play a key role. "Diabesity" is a new term which refers to diabetes occurring in the context of obesity. In this article, we will discuss the epidemiology and impact of diabetes and obesity and will also outline the components of the metabolic syndrome and the studies that demonstrate that screening and prevention are possible in an attempt to control this epidemic. PMID:24010754

Riob Servn, Pilar

2013-09-01

147

Diabetic radiculoplexus neuropathies.  

PubMed

Diabetic radiculoplexus neuropathies (DRPN) are neuropathies clinically and pathologically distinct from the neuropathy typically associated with diabetes (DPN). DRPN are usually subacute in onset, painful, and often demonstrate a monophasic course with incomplete recovery. Pathologically, these neuropathies are due to ischemic injury from altered immunity and often have features suggestive or diagnostic of microvasculitis. Unlike DPN, immune therapy may be helpful in treatment of these conditions given their pathological substrate and therefore are important to identify early and distinguish from other neuropathies that occur in patient with diabetes. PMID:25410213

Laughlin, Ruple S; Dyck, P James B

2014-01-01

148

Advances in diabetic retinopathy  

PubMed Central

Diabetic retinopathy (DR) is a complication of long-term diabetes mellitus (DM). Over the last 2 decades lot of work has been on early diagnosis of DR and screening programs have been designed to help the masses. Large numbers of clinical studies have been done for patients of diabetes and DR wherein the role of blood sugar control, metabolic control, role of oral medicines for DR, role of imaging, fluorescein angiography, and retinal photocoagulation has been studied. Newer treatment modalities are being devised and studied for better patient care. We discuss these issues in our review highlight and newer advances over the last few years. PMID:25364670

Agarwal, Prakashchand; Jindal, Ankita; Saini, V.K.; Jindal, Sushil

2014-01-01

149

Not all neuropathy in diabetes is of diabetic etiology: Differential diagnosis of diabetic neuropathy  

Microsoft Academic Search

Diabetic peripheral neuropathy is the most common peripheral neuropathy in the developed world; however, not all patients\\u000a with diabetes and peripheral nerve disease have a peripheral neuropathy caused by diabetes. Several (although not all) studies\\u000a have drawn attention to the presence of other potential causes of a neuropathy in individuals with diabetes; 10% to 50% of\\u000a individuals with diabetes may

Roy Freeman

2009-01-01

150

Diabetes and Dietary Supplements  

MedlinePLUS

... health approaches, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does ... Chinese herbal medicine for diabetic peripheral neuropathy. Cochrane Database of Systematic Reviews . 2011;(6):CD007796. Accessed at ...

151

Hyperglycemia and Diabetic Ketoacidosis  

MedlinePLUS

... blood sugar levels daily with a blood glucose meter . Doing so will help you identify when your ... not expired. Make sure that all equipment (pumps, meters, etc.) is working properly. Diabetes medications may need ...

152

American Diabetes Association  

MedlinePLUS

... Join us in Celebrating 75 years of Discovery, Innovation and Progress. And explore our timeline! Its Black ... camp.html Registration for Diabetes Camp is Now Open! Our camps make a difference in the lives ...

153

Personalized diabetes management  

E-print Network

In this thesis, we present a system to make personalized lifestyle and health decisions for diabetes management, as well as for general health and diet management. In particular, we address the following components of the ...

O'Hair, Allison Kelly

2013-01-01

154

Diabetes - eye care  

MedlinePLUS

... so you can read them easily. Use rubber bands or clips to tell medicine bottles apart. Ask ... al. Complications of diabetes mellitus. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of ...

155

Diabetes in African Americans  

MedlinePLUS

... Moving towards prevention of Type 2 Diabetes This music CD helps African Americans incorporate more physical activity ... move more. Three songs from the popular Movimiento music CD also are included. This CD also contains ...

156

Diabetic Eye Problems  

MedlinePLUS

... too high. Over time, this can damage your eyes. The most common problem is diabetic retinopathy. It ... light-sensitive tissue at the back of your eye. You need a healthy retina to see clearly. ...

157

Diabetes: Oral Effects  

MedlinePLUS

... can be dramatic. People with diabetes can have: Periodontal (gum) disease that gets worse rapidly Gum inflammation ( ... white blood cells, a main defense against infection. Periodontal disease is a bacterial infection, so people with ...

158

Diabetes: Dental Tips  

MedlinePLUS

... diabetes are at risk for mouth infections, especially periodontal (gum) disease. Periodontal disease can damage the gum and bone that ... people with serious gum disease lose their teeth. Periodontal disease may also make it hard to control ...

159

National Diabetes Information Clearinghouse  

MedlinePLUS

... 7384929 Email: ndic@info.niddk.nih.gov Internet: www.diabetes.niddk.nih.gov NIH...Turning Discovery Into Health Privacy Statement | Disclaimers | Accessibility | PDF versions require the free ...

160

Medicines for Diabetes  

MedlinePLUS

... a kid also eats healthy and exercises regularly. Glucagon Insulin and other diabetes medicines help to keep ... has really low blood sugar might need a glucagon shot. Glucagon (say: GLOO-kuh-gon) is a ...

161

Management of diabetic gastroparesis.  

PubMed

Diabetic gastroparesis is a long term complication of diabetes mellitus which could basically be defined as dysregulated gastric emptying leading to various pathological, biochemical and clinical changes in absence of any structural changes. Symptoms include nausea, vomiting, bloating, epigastric pain, anorexia, weight loss and so on. For symptomatic gastroparesis prokinetic drugs like metoclopramide, domperidone, cisapride, erythromycin and itcopride are used. Itopride is currently emerging as a prokinetic drug of choice. There is also scope of surgery. PMID:16173296

Mukhopadhyay, Pradip; Basu, A K

2005-03-01

162

Diabetes in Canadian Women  

Microsoft Academic Search

HEALTH ISSUE: Diabetes mellitus (DM) is a chronic health condition affecting 4.8% of Canadian adults ? 20 years of age. The prevalence increases with age. According to the National Diabetes Surveillance System (NDSS) (19981999), approximately 12% of Canadians aged 6074 years are affected. One-third of cases may remain undiagnosed. The projected increase in DM prevalence largely results from rising rates

Catherine Kelly; Gillian L. Booth

2004-01-01

163

The Diabetic Foot  

Microsoft Academic Search

Diabetic foot problems remain all too common and are likely to increase in prevalence over the next few decades. It has been\\u000a estimated that an individual with diabetes now has a 25% risk of developing a foot ulcer at some time during their lifespan.\\u000a A number of controversies are discussed in this chapter starting with the key question of the

Andrew J. M. Boulton

164

Diabetes and foot care.  

PubMed

Essential facts People with diabetes are 30 times more likely to have an amputation than those without the condition, and up to 80 per cent of these are believed to be preventable. There are more than 6,000 amputations a year in England. These operations are costly to the NHS and have a devastating effect on the patient. Only 50 per cent of people with diabetes who undergo an amputation survive for two years. PMID:25627508

2015-01-28

165

Sexual and Urologic Problems of Diabetes  

MedlinePLUS

... Info Statistics Research Resources About Us Espaol National Diabetes Information Clearinghouse Publications Tools and Resources E-News ... Problems of Diabetes Sexual and Urologic Problems of Diabetes On this page: Diabetes and Sexual Problems What ...

166

Diabetes Facts and Myths (For Parents)  

MedlinePLUS

... team first. Myth: Eating too much sugar causes diabetes. Fact: Type 1 diabetes is caused by a ... risk for developing the disease. Myth: Kids with diabetes can never eat sweets. Fact: Kids with diabetes ...

167

Major Risk Factors for Heart Disease: Diabetes  

MedlinePLUS

... diabetes that most commonly develops in adulthood is type 2 diabetes. In type 2 diabetes, the pancreas makes insulin, but the body ... and gradually loses the ability to produce it. Type 2 diabetes is a serious disease. In addition to ...

168

JAMA Patient Page: Diabetic Foot Ulcers  

MedlinePLUS

... of the American Medical Association JAMA PATIENT PAGE Diabetic Foot Ulcers D iabetic foot ulcers are sores ... article about preventing diabetic foot ulcers. WHAT CAUSES DIABETIC FOOT ULCERS? FOR MORE INFORMATION National Diabetes Information ...

169

Neuropeptides and diabetic retinopathy  

PubMed Central

Diabetic retinopathy, a common complication of diabetes, develops in 75% of patients with type 1 and 50% of patients with type 2 diabetes, progressing to legal blindness in about 5%. In the recent years, considerable efforts have been put into finding treatments for this condition. It has been discovered that peptidergic mechanisms (neuropeptides and their analogues, activating a diverse array of signal transduction pathways through their multiple receptors) are potentially important for consideration in drug development strategies. A considerable amount of knowledge has been accumulated over the last three decades on human retinal neuropeptides and those elements in the pathomechanisms of diabetic retinopathy which might be related to peptidergic signal transduction. Here, human retinal neuropeptides and their receptors are reviewed, along with the theories relevant to the pathogenesis of diabetic retinopathy both in humans and in experimental models. By collating this information, the curative potential of certain neupeptides and their analogues/antagonists can also be discussed, along with the existing clinical treatments of diabetic retinopathy. The most promising peptidergic pathways for which treatment strategies may be developed at present are stimulation of the somatostatin-related pathway and the pituitary adenylyl cyclase-activating polypeptide-related pathway or inhibition of angiotensinergic mechanisms. These approaches may result in the inhibition of vascular endothelial growth factor production and neuronal apoptosis; therefore, both the optical quality of the image and the processing capability of the neural circuit in the retina may be saved. PMID:23043302

Gbriel, Robert

2013-01-01

170

Zinc and Diabetic Retinopathy  

PubMed Central

Zinc (Zn) is an important nutrient that is involved in various physiological metabolisms. Zn dyshomeostasis is often associated with various pathogeneses of chronic diseases, such as metabolic syndrome, diabetes, and related complications. Zn is present in ocular tissue in high concentrations, particularly in the retina and choroid. Zn deficiencies have been shown to affect ocular development, cataracts, age-related macular degeneration, and even diabetic retinopathy. However, the mechanism by which Zn deficiency increases the prevalence of diabetic retinopathy remains unclear. In addition, due to the negative effect of Zn deficiency on the eye, Zn supplementation should prevent diabetic retinopathy; however, limited available data do not always support this notion. Therefore, the goal of this paper was to summarize these pieces of available information regarding Zn prevention of diabetic retinopathy. Current theories and possible mechanisms underlying the role of Zn in the eye-related diseases are discussed. The possible factors that affect the preventive effect of Zn supplementation on diabetic retinopathy were also discussed. PMID:23671870

Miao, Xiao; Sun, Weixia; Miao, Lining; Fu, Yaowen; Wang, Yonggang; Su, Guanfang; Liu, Quan

2013-01-01

171

Osteoporosis, Fractures, and Diabetes  

PubMed Central

It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ?6 times and is due to low bone mass. Despite increased bone mineral density (BMD), in patients with type 2 diabetes the risk is increased (which is about twice the risk in the general population) due to the inferior quality of bone. Bone fragility in type 2 diabetes, which is not reflected by bone mineral density, depends on bone quality deterioration rather than bone mass reduction. Thus, surrogate markers and examination methods are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM patients. One of these methods can be trabecular bone score. The aim of the paper is to present the present state of scientific knowledge about the osteoporosis risk in diabetic patient. The review also discusses the possibility of problematic using the study conclusions in real clinical practice. PMID:25050121

2014-01-01

172

Determinants of diabetes knowledge in a cohort of Nigerian diabetics  

PubMed Central

Background One of the consequences of the generational paradigm shift of lifestyle from the traditional African model to a more "western" standard is a replacement of communicable diseases by non-communicable or life style related diseases like diabetes. To address this trend, diabetes education along with continuous assessment of diabetes related knowledge has been advocated. Since most of the Nigerian studies assessing knowledge of diabetes were hospital-based, we decided to evaluate the diabetes related knowledge and its sociodemographic determinants in a general population of diabetics. Methods Diabetics (n?=?184) attending the 2012 world diabetes day celebration in a Nigerian community were surveyed using a two part questionnaire. Section A elicited information on their demographics characteristics and participation in update courses, and exercise, while section B assessed knowledge of diabetes using the 14 item Michigan Diabetes Research and Training Centre's Brief Diabetes Knowledge Test. Results We found that Nigerian diabetics had poor knowledge of diabetes, with pervasive fallacies. Majority did not have knowledge of "diabetes diet", "fatty food", "free food", effect of unsweetened fruit juice on blood glucose, treatment of hypoglycaemia, and the average duration glycosylated haemoglobin (haemoglobin A1) test measures blood glucose. Attaining tertiary education, falling under the 51-60years age group, frequent attendance at seminars/updates and satisfaction with education received, being employed by or formerly working for the government, and claiming an intermediate, or wealthy income status was associated with better knowledge of diabetes. Conclusion Nigerian diabetics' knowledge of diabetes was poor and related to age, level of education, satisfaction with education received, employment status and household wealth. PMID:24593904

2014-01-01

173

[And what about diabetes?].  

PubMed

Type 2, non-insulin-dependent diabetes has been increasing exponentially over the past decade and a half and it is estimated that within short it will comprise more than 350 million patients. The pathophysiology of type 2 diabetes is complex, but has two dominating factors, insulin resistance (which is mainly due to obesity and physical inactivity), and deficient insulin production. Indeed, although approximately 80% of type 2 diabetics are obese, 2/3 of overweight or obese persons show normal glucose metabolism. Data accumulated over the past few decades unequivocally indicate that diabetes can not develop in the absence of a major deficiency of insulin secretion. This deficiency is characterised by an early loss of first-phase insulin response to glucose, followed by gradual collapse of the later insulin response as well as of the maximal secretory capacity of the beta-cell. Interestingly, functional modifications in the beta-cell do not present a discontinuity; in fact, some of the characteristics of the diabetic beta-cell function can be found in a fraction of the healthy population. A major challenge has been to answer the question whether the population with decreased insulin secretory capacity represents the substratum from which future diabetics emerge. While many observations suggest that such may indeed be the case, conclusive evidence is still unavailable. The search for the beta-cell molecular mechanisms which prepare the ground for diabetes has been difficult and mainly limited to laboratory models of type 2 diabetes. Greater success has been achieved in elucidating the secondary beta-cell defects elicited once diabetes is established and the beta-cell exposed to chronically elevated glucose and fatty acid levels (so-called gluco-lipotoxicity). The latter reduces the responsiveness of insulin secretion to physiological stimuli, as it impairs the biosynthesis and processing of proinsulin. The leptin resistance of obesity certainly plays a role in this context, since leptin reduces, i.a., the lipid content of the islet. Similarly, the reduced adiponectin levels of obesity favour diminished beta-cell function. Nevertheless, it seems probable that the most important negative factor for the beta-cell in obesity is the inflammatory state. Indeed, several cytokines are deleterious for the beta-cell and may play a role in the pathogenesis of the islet dysfunction of diabetes, as demonstrated by the recent work of Donath and coworkers. We propose the working hypothesis that the "prediabetic" beta-cell in fact is a normal beta-cell whose functional capabilities (insulin secretion and biosynthesis, cell proliferation, resistance to stress...) is at the lower-end of the normal distribution. At times of "reasonable" metabolic requirements, i.e. reasonable energy balance, such a "prediabetic" beta-cell is fully adequate to cover the insulin needs of the organism. Insulin production by the "prediabetic" beta-cell becomes insufficient either when insulin needs become excessive, as is the case in over-nutrition (with or without insulin resistance), or when beta-cell function and adaptation are impaired by "external" factors such as the obesity-related inflammatory cytokines. Thus, deficient beta-cell function is seen as a relative factor against the metabolic background dictated by environmental factors. Type 2 diabetes is a hereditary disease, and many genes have been shown to be linked to diabetes. Our hypothesis is that such genes (or rather their polymorphism) define the range of the functional adaptability of the beta-cell to metabolic demand. This would be an excellent example of gene-environment interaction. Thus, we do not believe that sensu stricto diabetes genes exist. Against the above, optimal diabetes treatment would necessitate--reduction of the metabolic demand on the beta-cell,--support of its function and adaptive capabilities. Several new research avenues, discussed in the present meeting, may open new and improved therapeutic approaches for type 2 diabetes.

Cerasi, Erol

2007-01-01

174

Diabetic cardiomyopathy, causes and effects  

PubMed Central

Diabetes is associated with increased incidence of heart failure even after controlling for coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become an increasingly recognized entity among clinicians, a better understanding of its pathophysiology is necessary for early diagnosis and the development of treatment strategies for diabetes-associated cardiovascular dysfunction. We will review recent basic and clinical research into the manifestations and the pathophysiological mechanisms of diabetic cardiomyopathy. The discussion will be focused on the structural, functional and metabolic changes that occur in the myocardium in diabetes and how these changes may contribute to the development of diabetic cardiomyopathy in affected humans and relevant animal models. PMID:20180026

Boudina, Sihem

2010-01-01

175

Cutaneous signs of diabetes mellitus.  

PubMed

Cutaneous signs of diabetes mellitus are extremely valuable to both the clinician and the researcher. Lesions such as necrobiosis lipoidica diabeticorum, diabetic dermopathy, carotenemia idiopathic bullous eruptions of granuloma anulare alert the physician to consider the diagnosis of diabetes mellitus. Xanthomas reflect the status of glucose and lipid metabolism. Diabetic dermopathy might be a useful monitor of angiopathic changes in the heart, kidney and brain. Finally, the accessibility of the skin makes it an ideal organ for studying the pathogenesis of diabetes and the effect of medications on the vascular and neurological complications of diabetes. PMID:797552

Stawiski, M A; Voorhees, J J

1976-09-01

176

Si, Yo Puedo Controlar Mi Diabetes!  

E-print Network

¡Si, Yo Puedo Controlar Mi Diabetes! ¡Si, Yo Puedo Controlar Mí Diabetes! (Si, Yo Puedo/Latinos with diabetes. The curriculum is predicated on the American Diabetes Association's national standards of care and lifestyle skills to better control their diabetes. Relevance · Diabetes costs Texas more than 12 billion

177

Autophagy in Diabetic Nephropathy  

PubMed Central

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide, and is associated with increased morbidity and mortality in patients with both type 1 and type 2 diabetes. Increasing prevalence of diabetes has made the need for effective treatment of DN critical, and identifying new therapeutic targets to improve clinical management. Autophagy is a highly conserved self-eating pathway by which cells degrade and recycle macromolecules and organelles. Autophagy serves as an essential mechanism to maintain homeostasis of glomeruli and tubules, and plays important roles in human health and diseases. Impairment of autophagy is implicated in the pathogenesis of DN. Emerging body of evidence suggests that targeting the autophagic pathway to activate and restore autophagy activity may be renoprotective. Here we review current advances in our understanding of the roles of autophagy in diabetic kidney injury, focusing on studies in renal cells in culture, human kidney tissues, and experimental animal models of diabetes. We discuss the major nutrient-sensing signal pathways, and diabetes-induced altered intracellular metabolism and cellular events, including accumulation of advanced glycation end-products, increased oxidative stress, endoplasmic reticulum stress, hypoxia, and activation of the renin angiotensin system, which modulate autophagic activity and contribute to the development of DN. We also highlight recent studies of autophagy and transforming growth factor-? in renal fibrosis, the final common response to injury that ultimately leads to end-stage kidney failure in both type 1 and type 2 diabetes. These findings suggest the possibility that autophagy can be a therapeutic target against DN. PMID:25349246

Ding, Yan; Choi, Mary E.

2014-01-01

178

Autophagy in diabetic nephropathy.  

PubMed

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide, and is associated with increased morbidity and mortality in patients with both type 1 and type 2 diabetes. Increasing prevalence of diabetes has made the need for effective treatment of DN critical and thereby identifying new therapeutic targets to improve clinical management. Autophagy is a highly conserved 'self-eating' pathway by which cells degrade and recycle macromolecules and organelles. Autophagy serves as an essential mechanism to maintain homeostasis of glomeruli and tubules, and plays important roles in human health and diseases. Impairment of autophagy is implicated in the pathogenesis of DN. Emerging body of evidence suggests that targeting the autophagic pathway to activate and restore autophagy activity may be renoprotective. In this review, we examine current advances in our understanding of the roles of autophagy in diabetic kidney injury, focusing on studies in renal cells in culture, human kidney tissues, and experimental animal models of diabetes. We discuss the major nutrient-sensing signal pathways and diabetes-induced altered intracellular metabolism and cellular events, including accumulation of advanced glycation end-products, increased oxidative stress, endoplasmic reticulum stress, hypoxia, and activation of the renin-angiotensin system, which modulate autophagic activity and contribute to the development of DN. We also highlight recent studies of autophagy and transforming growth factor-? in renal fibrosis, the final common response to injury that ultimately leads to end-stage kidney failure in both type 1 and type 2 diabetes. These findings suggest the possibility that autophagy can be a therapeutic target against DN. PMID:25349246

Ding, Yan; Choi, Mary E

2015-01-01

179

[Management of diabetic retinopathy and diabetic maculopathy in elderly patients with diabetes mellitus].  

PubMed

The world's population is aging, and simultaneously, the prevalence of diabetes mellitus worldwide is rapidly increasing. Therefore, the clinical management of diabetic retinopathy and diabetic maculopathy in elderly patients with diabetes is increasingly becoming more important. Therefore, collaboration between ophthalmologists and physicians is mandatory. The international clinical diabetic retinopathy and macular edema disease severity scales are very useful for information sharing between ophthalmologists and diabetologists. This review describes a strategy to assess symptoms of diabetes, including the clinical course of retinopathy and maculopathy, pathological changes, and pathogenesis, as well as details an updated treatment modality. Elderly patients tend to present with multiple complications that should be considered by the management team. PMID:24397174

Nishitsuka, Koichi; Yamashita, Hidetoshi

2013-11-01

180

Integration of Diabetes Education in Type 2 Diabetes Care  

Microsoft Academic Search

General knowledge of diabetes, adherence to medication, lifestyle changes, and selfmonitoring of blood glucose are surrogate end points. Diabetes self-management training programs should emphasize the need for a multifaceted attack against the risk factors for both macro- and microvascular disease, be collaborative and have repetitive educational sessions. Because a target-driven attitude of diabetes care providers is of major importance, the

G. Rutten

2005-01-01

181

Diabetic macro- and microvascular disease in type 2 diabetes  

Microsoft Academic Search

Before a patient develops overt type 2 diabetes mellitus, there is typically a prolonged period of patho-physiological change. In the common form of type 2 diabetes mellitus, there are years of insulin resistance, initially compensated by increased beta cell function, then impaired glucose tolerance develops, and finally type 2 diabetes. We know from studies such as the United Kingdom Prospective

Michel P Hermans

2007-01-01

182

Cigarette Smoking and Insulin Resistance in Patients with Noninsulin-Dependent Diabetes Mellitus  

Microsoft Academic Search

To evaluate the effects of chronic cigarette smoking on insulin sensitivity in patients with noninsulin-dependent diabetes mellitus (NIDDM), we examined 28 smokers and 12 nonsmokers with NIDDM, of similar sex, age, body mass index, waist\\/hip ratio, alcohol con- sumption, physical activity level, glycometabolic control, diabetes du- ration, and treatment. Insulin and C-peptide responses to oral glucose load were significantly higher

GIOVANNI TARGHER; MARIA ALBERICHE; MARINA B. ZENERE; RICCARDO C. BONADONNA; MICHELE MUGGEO; ENZO BONORA

183

Maternal complications in diabetic pregnancy.  

PubMed

Pregnant women with diabetes have to manage both the effect of pregnancy on glucose control and its effect on pre-existing diabetic complications. Most women experience hypoglycaemia as a consequence of tightened glycaemic control and this impacts on daily living. Less commonly, diabetic ketoacidosis, a serious metabolic decompensation of diabetic control and a medical emergency, can cause foetal and maternal mortality. Microvascular complications of diabetes include retinopathy and nephropathy. Retinopathy can deteriorate during pregnancy; hence, regular routine examination is required and, if indicated, ophthalmological input. Diabetic nephropathy significantly increases the risk of obstetric complications and impacts on foetal outcomes. Pregnancy outcome is closely related to pre-pregnancy renal function. Diabetic pregnancy is contraindicated if the maternal complications of ischaemic heart disease or diabetic gastropathy are known to be present before pregnancy as there is a significant maternal mortality associated with both of these conditions. PMID:21130689

Hawthorne, Gillian

2011-02-01

184

What is Diabetic Eye Disease?  

MedlinePLUS Videos and Cool Tools

... United States, there are 14 million people with diabetes and while most will not lose their vision ... good deal higher among people with Type I diabetes -- the type that usually begins in childhood and ...

185

Are Seniors with Diabetes Overtreated?  

MedlinePLUS

... said Garber, a professor of diabetes, endocrinology and metabolism. "An equally valid conclusion is that it shows ... M.D., Ph.D., professor, diabetes, endocrinology and metabolism, Baylor College of Medicine, Houston, Texas; Jan. 12, ...

186

Peripheral Artery Disease and Diabetes  

MedlinePLUS

... High Blood Pressure Tools & Resources Stroke More Peripheral Artery Disease & Diabetes Updated:Oct 7,2014 People with diabetes are at higher risk of developing peripheral artery disease (PAD) . And individuals with PAD are four ...

187

Cranial mononeuropathy III - diabetic type  

MedlinePLUS

Diabetic third nerve palsy; Pupil-sparing third cranial nerve palsy ... Cranial mononeuropathy III - diabetic type -- is a mononeuropathy . This means that only one nerve is damaged. The condition affects the third cranial (oculomotor) ...

188

Emergency Meal Planning for Diabetics  

MedlinePLUS

... Avoid high potassium fruit juices (orange juice). THREE-DAY DIABETIC GROCERY LIST FOR EMERGENCIES Item Amount (per ... Other Distilled water 5 one gallon jugs THREE-DAY DIABETIC MEAL PLAN FOR EMERGENCIES The sample meal ...

189

[Skin disorders in diabetes mellitus].  

PubMed

Diabetes mellitus is one of the most common diseases in the Western industrialized countries with about 300 million affected patients worldwide. The hyperglycemic state of diabetes mellitus leads to changes in practically every cell type and organ of the human body. Skin changes are considered the most common manifestations of diabetes mellitus. As skin changes can manifest before onset of diabetes mellitus they may have a diagnostic relevance. Other changes and diseases of the skin develop during the course of diabetes mellitus and may be associated with complications in internal organs or may occur as an adverse effect of antidiabetic therapy. In particular the presence of the diabetic foot syndrome is associated with significantly increased morbidity and mortality of diabetes patients as well as with markedly elevated direct and indirect costs for the health care system. In this article the most common skin diseases of patients with diabetes mellitus as well as their pathophysiology and current treatment are reviewed. PMID:25262886

Gkogkolou, Paraskevi; Bhm, Markus

2014-10-01

190

Hypoxia in Diabetic Kidneys  

PubMed Central

Diabetic nephropathy (DN) is now a leading cause of end-stage renal disease. In addition, DN accounts for the increased mortality in type 1 and type 2 diabetes, and then patients without DN achieve long-term survival compatible with general population. Hypoxia represents an early event in the development and progression of DN, and hypoxia-inducible factor- (HIF-) 1 mediates the metabolic responses to renal hypoxia. Diabetes induces the fraternal twins of hypoxia, that is, pseudohypoxia and hypoxia. The kidneys are susceptible to hyperoxia because they accept 20% of the cardiac output. Therefore, the kidneys have specific vasculature to avoid hyperoxia, that is, AV oxygen shunting. The NAD-dependent histone deacetylases (HDACs) sirtuins are seven mammalian proteins, SIRTs 17, which are known to modulate longevity and metabolism. Recent studies demonstrated that some isoforms of sirtuins inhibit the activation of HIF by deacetylation or noncatalyzing effects. The kidneys, which have a vascular system that protects them against hyperoxia, unfortunately experience extraordinary hypernutrition today. Then, an unexpected overload of glucose augments the oxygen consumption, which ironically results in hypoxia. This review highlights the primary role of HIF in diabetic kidneys for the metabolic adaptation to diabetes-induced hypoxia. PMID:25054148

Takiyama, Yumi; Haneda, Masakazu

2014-01-01

191

Treating the obese diabetic.  

PubMed

Type 2 diabetes and obesity are intimately linked; reduction of bodyweight improves glycemic control, mortality and morbidity. Treating obesity in the diabetic is hampered as some diabetic treatments lead to weight gain. Bariatric surgery is currently the most effective antiobesity treatment and causes long-term remission of diabetes in many patients. However, surgery has a high cost and is associated with a significant risk of complications, and in practical terms only limited numbers can undergo this therapy. The choice of pharmacological agents suitable for treatment of diabetes and obesity is currently limited. The glucagon-like peptide-1 receptor agonists improve glycemia and induce a modest weight loss, but there are doubts over their long-term safety. New drugs such as lorcaserin and phentermine/topiramate are being approved for obesity and have modest, salutary effects on glycemia, but again long-term safety is unclear. This article will also examine some future avenues for development, including gut hormone analogues that promise to combine powerful weight reduction with beneficial effects on glucose metabolism. PMID:23473594

Kenkre, Julia; Tan, Tricia; Bloom, Stephen

2013-03-01

192

Diabetic retinopathy and pregnancy.  

PubMed

Diabetes mellitus and pregnancy have reciprocal influences between them, therefore diabetes mellitus may complicate the course of pregnancy as well as pregnancy can worsen the performance of diabetes especially at the fundus oculi. Several factors seem to play a role in retinal neovascularization. Actually it's not possible to understand the mechanisms underlying this progression. Moreover chronic hyperglycemia leads to several events such as: the activation of aldose reductase metabolic pathway, the activation of the diacylglycerol-protein kinase C, the non-enzymatic glycation of proteins with formation of advanced glycation endproducts and the increase of hexosamines pathway. Although every structure of the eye can be affected by diabetes, retinal tissue, with all its vessels, is particularly susceptible. Pregnancy may promote the onset of diabetic retinopathy, in about 10 % of cases, as well as contribute to its worsening when already present. The proliferative retinopathy must always be treated; treatment should be earlier in pregnant women compared to non-pregnant women. Pregnancy can also cause macular edema; it spontaneously regresses during the postpartum and therefore does not require immediate treatment. In summary, collaboration between the various specialists is primary to ensure the best outcomes for both mother's health and sight, and fetus' health. PMID:24482250

Pescosolido, Nicola; Campagna, Orazio; Barbato, Andrea

2014-08-01

193

Periodontal health and diabetes awareness among Saudi diabetes patients  

PubMed Central

Purpose This study aimed to examine diabetic patients in Jeddah, Saudi Arabia, regarding their general diabetic and oral health-related awareness and practices, their awareness of the association of diabetes with periodontal disease, and their sources of diabetes-related information. Methods Diabetic patients (n=454) who were receiving care at the diabetes clinic in King Abdulaziz University Hospital, Jeddah, Saudi Arabia, from October 2013 to May 2014, completed a six-part questionnaire assessing their sociodemographic characteristics, general and oral health awareness and practices, and sources of diabetes-related information. Descriptive statistics were used to report the results. Results The responses indicated inadequate health-related practices in the surveyed group: 22.2% brushed their teeth twice daily, 73.6% never flossed their teeth, and while 80.2% visited a physician in the past year, only 12.6% visited a dentist during the same year. Of the respondents, 94.8% reported that they had never received advice on oral hygiene tasks in relation to diabetes from a health professional. Awareness about the diabetes and periodontal disease association was limited: 46.7% knew that diabetics have gum problems more often if their blood sugar stays very high, and only 21.8% knew that gum disease makes it harder to control blood sugar in diabetic patients. A significant association (P<0.05) was found between a higher level of education and greater general and oral awareness, as well as a significant association (P<0.05) between longer duration of disease, regular exercise, and regular visits to the physician and awareness about diabetes mellitus. Additionally, a significant association (P<0.05) was found between regular dental visits and both periodontal disease and diabetes awareness. Family and friends were the main source of diabetes-related information, and the Internet was the least likely source. Conclusion Customized educational programs should be planned for diabetic patients according to community needs. PMID:25673974

Bahammam, Maha A

2015-01-01

194

Problems of diabetics in prison  

Microsoft Academic Search

Providing care for diabetics is difficult in prison. Six diabetic prisoners or former prisoners were seen whose care was difficult or unsatisfactory. Three had multiple admissions to hospital during their sentences with diabetic ketoacidosis that they induced themselves by not taking insulin. The motive seemed to be removal from prison to the fairly pleasant surroundings of the local hospital. A

G. V. Gill; I. A. MacFarlane

1989-01-01

195

Thyroid Disorders and Diabetes Mellitus  

PubMed Central

Studies have found that diabetes and thyroid disorders tend to coexist in patients. Both conditions involve a dysfunction of the endocrine system. Thyroid disorders can have a major impact on glucose control, and untreated thyroid disorders affect the management of diabetes in patients. Consequently, a systematic approach to thyroid testing in patients with diabetes is recommended. PMID:21785689

Hage, Mirella; Zantout, Mira S.; Azar, Sami T.

2011-01-01

196

DIABETES PREVENTION TRIAL TYPE 1  

EPA Science Inventory

The Diabetes Prevention Trial--Type 1 (DPT-1) is a nationwide study to see if we can prevent or delay type 1 diabetes, also known as insulin-dependent diabetes. Nine medical centers and more than 350 clinics in the United States and Canada are taking part in the study....

197

Common crossroads in diabetes management  

Microsoft Academic Search

The prevalence and impact of type 2 diabetes are reaching epidemic proportions in the United States. Data suggest that effective management can reduce the risk for both microvascular and macrovascular complications of diabetes. In treating patients with diabetes, physicians must be prepared not only to tailor the initial treatment to the individual and his or her disease severity but also

Michael Valitutto

2008-01-01

198

Diabetic Youths and Their Families  

ERIC Educational Resources Information Center

In response to a need for a comprehensive program to fill the gap in services for children with diabetes and their families, the Diabetic Youth and Family Program of Wichita, Kansas is directing efforts to deal effectively and creatively with children's diabetic problems. (CS)

Smith, Melva

1974-01-01

199

Lucentis Approved for Diabetic Retinopathy  

MedlinePLUS

... this page, please enable JavaScript. Lucentis Approved for Diabetic Retinopathy Among diabetics with macular edema (*this news item will not ... Roberts Monday, February 9, 2015 Related MedlinePlus Pages Diabetic Eye Problems Medicines MONDAY, Feb. 9, 2015 (HealthDay ...

200

[Diabetic nephropathy--update 2012].  

PubMed

Diabetes mellitus is the leading single cause for renal replacement therapy. Its development and progression, however, can be ameliorated by adequate therapy. The present article represents the recommendations of the Austrian Diabetes Association and the Austrian Society for Nephrology for the prevention and treatment of diabetic nephropathy. PMID:23262747

Auinger, Martin; Edlinger, Roland; Prischl, Friedrich; Kautzky-Willer, Alexandra; Prager, Rudolf; Rosenkranz, Alexander R; Roden, Michael; Saemann, Marcus; Clodi, Martin; Schernthaner, Guntram

2012-12-01

201

Case 22:Type II diabetes  

Technology Transfer Automated Retrieval System (TEKTRAN)

Diabetes mellitus is characterized by elevated blood glucose levels. It is composed of two types depending on the pathogenesis. Type I diabetes is characterized by insulin deficiency and usually has its onset during childhood or teenage years. This is also called ketosis-prone diabetes. Type II diab...

202

Gut feelings about diabetes  

PubMed Central

Studies of patients going into diabetes remission after gastric bypass surgery have demonstrated the important role of the gut in glucose control. The improvement of type 2 diabetes after gastric bypass surgery occurs via weight dependent and weight independent mechanisms. The rapid improvement of glucose levels within days after the surgery, in relation to change of meal pattern, rapid nutrient transit, enhanced incretin release and improved incretin effect on insulin secretion, suggest mechanisms independent of weight loss. Alternatively, insulin sensitivity improves over time as a function of weight loss. The role of bile acids and microbiome in the metabolic improvement after bariatric surgery remains to be determined. While most patients after bariatric surgery experienced sustained weight loss and improved metabolism, small scale studies have shown weight regain and diabetes relapse, the mechanisms of which remain unknown. PMID:22386248

Laferrre, Blandine

2013-01-01

203

[Infection and diabetic foot].  

PubMed

The large number of factors that influence the outcome of patients with diabetic foot infections calls for a multidisciplinary management of such patients. Infection is always the consequence of a preexisting foot wound whose chronicity is facilitated by the diabetic peripheral neuropathy, whereas peripheral vascular disease is a factor of poor outcome, especially regarding the risk for leg amputation. Primary and secondary prevention of IPD depends both on the efficacy of wound off-loading. Antibiotic treatment should only be considered for clinically infected foot wounds for which diagnostic criteria have recently been proposed by international consensus. The choice of the antibiotic regimen should take into account the risk for selecting bacterial resistance, and as a consequence, agents with a narrow spectrum of activity should be preferred. Respect of the measures for preventing the spread of bacterial resistance in diabetic foot centers is particularly important. PMID:18822250

Senneville, E

2008-09-01

204

Diabetes and the internet.  

PubMed

This paper examines what the World Wide Web has to offer patients, families and professionals in relation to diabetes. The potential pitfalls and dangers are discussed, leading to a wider debate on how the Internet can be expected to impact upon diabetes and other health care provision in the near future, and how health care professionals' practices will have to change. Themes include: the World Wide Web (finding material, assessing authenticity, pitfalls for patients, personalized pages, chat rooms, security); e-mail consultation (benefits, risks, minimizing risk, what to tell patients, legal constraints, security); telemedicine (telemetry, surveillance, security); search engines (journals, etc.); looking ahead (digital television, web-based medical records). PMID:11979038

Robertson, Kenneth J

2002-01-01

205

Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats.  

PubMed

Diabetic nephropathy is a major cause of morbidity and mortality in diabetic patients. To prevent the development of this disease and to improve advanced kidney injury, effective therapies directed toward the key molecular target are required. In this paper, the efficacy of fenugreek to restore the kidney function of diabetic rats via its antioxidant and anti-inflammatory activities has been studied. Novel data showing the efficacy of fenugreek to attenuate progression of diabetic nephropathy and production of interleukin-6 (IL-6) in rats compared with a diabetic untreated group were obtained. Rats were classified into five groups; control, diabetic untreated, and three diabetic groups treated with fenugreek, rosiglitazone, and metformin. Treatment with fenugreek has been continued for 12 weeks. Fenugreek was found to significantly reduce the high levels of glucose, urea, creatinine, sodium, potassium, and IL-6 in serum compared with the diabetic untreated group. In addition, levels of malondialdehyde and IL-6 in the kidney homogenate were significantly reduced as a result of the fenugreek treatment compared with the diabetic untreated group. Moreover, concentration of GSH and the activity of both superoxide dismutase and catalase were considerably increased in the diabetic treated groups compared with the diabetic untreated group. Furthermore, glomerular mesangial expansion was reduced in the treated animal groups. These findings suggest a therapeutic potential of fenugreek against diabetic nephropathy, explain its antioxidative/anti-inflammatory properties and provide a direction for future research. PMID:22237966

Sayed, Ahmed Amir Radwan; Khalifa, Mahmoud; Abd el-Latif, Fathy Fahim

2012-06-01

206

Diabetes mellitus and oral health.  

PubMed

The oral health is influenced by systemic health, and one of the most common chronic diseases encountered in dental practice is diabetes mellitus. Diabetes can worsen oral infections and vice versa. In the literature, periodontitis and diabetes in the young to middle-aged adults have been the most widely researched area. Understanding the patho-physiology, clinical manifestations and management of different types of orofacial diseases in diabetic patients are important to the diabetologist and the dentist for the optimal care of patients with these diseases. This review explores the inter-link between diabetes and oral health. PMID:25487035

Kudiyirickal, Marina George; Pappachan, Joseph M

2014-12-01

207

Diabetes screening in the workplace.  

PubMed

The prevalence of diabetes has increased worldwide and the pathophysiological problems associated with diabetes increase the potential for employees' physical disabilities. These complications, including neuropathy, nephropathy, and visual impairment, negatively impact the job performance of employees and compromise workplace safety. Occupational health nurses can provide diabetes screening programs to employees and identify chronic disease risk factors early. This article describes an occupational diabetes screening program at a major corporation in Belize, Central America, defines diabetes, outlines the diabetes teaching plan, and presents the demographics of the participants and results of the screening. Cultural considerations and recommendations for future occupational diabetes screenings are proposed. [Workplace Health Saf 2014;62(11):444-446.]. PMID:25373027

Gulley, Tauna; Boggs, Dusta; Mullins, Rebecca; Brock, Emily

2014-11-01

208

77 FR 43096 - National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Diabetes Mellitus...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Diabetes and Digestive and Kidney Diseases; Notice of Diabetes Mellitus...Diabetes and Digestive and Kidney Diseases, 31 Center Drive, Building 31A...Diabetes, Dementia, and Alzheimer's Disease.'' Any member of the...

2012-07-23

209

Ghrelin, obesity and diabetes  

Microsoft Academic Search

The high prevalence of obesity and diabetes will lead to higher rates of morbidity and mortality. The search for drugs to treat these metabolic disorders has, therefore, intensified. The stomach-derived peptide ghrelin regulates food intake and body weight. Recent work suggests that ghrelin also controls glucose metabolism. In addition, current evidence suggests that most of the actions of ghrelin could

Petra Wiedmer; Rubn Nogueiras; Fabio Broglio; David D'Alessio; Matthias H Tschp

2007-01-01

210

Diabetes: The Science Inside  

NSDL National Science Digital Library

The purpose of this book is to provide basic information about type 2 diabetes: what causes it, how it affects the body, and how it can be prevented and treated. Supported byScience Education Partnership Award (SEPA)from the National Center for Research Resources Grant # 5R25RR15601.

Healthy People Library Project

2003-01-01

211

Diabetes: Dealing With Feelings  

MedlinePLUS

... or daughter, a sister or brother, a grandchild, student, friend, babysitter? Are you a future astronomer, teacher, doctor, or poet? Diabetes is really only a small part of who you are. Keep track of your dreams and hopes, and find time for the people and things you enjoy. Stick ...

212

Diabetes - tests and checkups  

MedlinePLUS

... if you have early kidney damage due to diabetes . But the level of this protein in urine can also be higher for other reasons. Your doctor will also have you take a blood test every year that measures how well your kidneys work.

213

Diabetes Personal Trainer Outcomes  

PubMed Central

OBJECTIVE To assess the social-cognitive, behavioral, and physiological outcomes of a self-management intervention for youth with type 1 diabetes. RESEARCH DESIGN AND METHODS A total of 81 youth with type 1 diabetes aged 1116 years were randomized to usual care versus a diabetes personal trainer intervention, consisting of six self-monitoring, goal-setting, and problem-solving sessions with trained non-professionals. Assessments were completed at baseline and multiple follow-up intervals. A1C data were obtained from medical records. ANCOVA adjusting for age and baseline values were conducted for each outcome. RESULTS At both short-term and 1-year follow-up, there was a trend for an overall intervention effect on A1C (short-term F = 3.71, P = 0.06; 1-year F = 3.79, P = 0.06) and a significant intervention-by-age interaction, indicating a great effect among older than younger youth (short-term F = 4.78, P = 0.03; 1-year F = 4.53, P = 0.04). Subgroup analyses demonstrated no treatment group difference among younger youth but a significant difference among the older youth. No treatment group differences in parent or youth report of adherence were observed. CONCLUSIONS The diabetes personal trainer intervention demonstrated significant effects in A1C among middle adolescents. PMID:17620445

Nansel, Tonja R.; Iannotti, Ronald J.; Simons-Morton, Bruce G.; Cox, Christopher; Plotnick, Leslie P.; Clark, Loretta M.; Zeitzoff, Linda

2008-01-01

214

Teen Diabetes Quiz  

MedlinePLUS

... Diabetes causes your: Blood glucose to be too low Blood glucose to be too high Body to stop making ... heart-healthy fats. When you drink milk, pick low-fat or nonfat milk. Remember that ... It also helps your body use blood glucose for energy. You don't have to play ...

215

Fibrocalculous pancreatic diabetes (FCPD).  

PubMed

Fibrocalculous pancreatic diabetes (FCPD) is an uncommon form of diabetes that occurs as a result of chronic calcific pancreatitis, in the absence of alcohol abuse. The disease is restricted to tropical regions of the world, and southern India has the highest known prevalence of FCPD. The typical patient with FCPD is a lean adolescent or young adult of either sex, presenting with history of recurrent bouts of abdominal pain and steatorrhea. Demonstration of large, discrete pancreatic calculi by plain radiographs or ultrasonography of the abdomen is diagnostic. While the exact etiology of FCPD is unknown, genetic, nutritional and inflammatory factors have been hypothesized to play a role. Diabetes in FCPD is often brittle and difficult to control; most patients require multiple doses of insulin for control of glycemia. However, in spite of high blood glucose levels, patients rarely develop ketosis. Malabsorption responds to pancreatic enzyme supplementation. Surgical removal of stones is indicated for symptomatic relief of intractable pain. While patients with FCPD develop microvascular complications as frequently as those with type 2 diabetes, macrovascular disease is uncommon. Development of pancreatic malignancy is the most dreaded complication and should be suspected in any patient who complains of weight loss, back pain or jaundice. PMID:25395047

Unnikrishnan, Ranjit; Mohan, Viswanathan

2014-11-14

216

Type 2 Diabetes  

MedlinePLUS

... fat, protein, and carbohydrates you need in your diet. Your meal plans should fit your lifestyle and habits and should include foods that you like. Managing your weight and having a well-balanced diet are important. Some people with type 2 diabetes ...

217

Treating Type 2 Diabetes  

MedlinePLUS

... should aim for the goal of keeping blood sugar levels as close to normal as possible. It is also important to treat other conditions that can be associated with type 2 diabetes, like obesity, high blood pressure, or abnormal blood lipid (fat) ...

218

Conversacin con Ricardo Monti  

E-print Network

las carreras suceda lo siguiente: yo quera ser e iba a ser escritor. Empec filosofa y curs seis o siete materias. Luego inici la carrera de psi cologa, pero mis estudios de psicologa se interrumpieron cuando estren mi primera obra de teatro... caos, organizar una serie de sensaciones e ideas, que impliquen cierta forma, cierta organizacin. Adems, cada obra ma se empalma con la otra, como si yo buscara obscuramente no solamente organizar ese caos en cada obra, sino ir organizndolo con...

Driskell, Charles B.

1979-04-01

219

Complications to Avoid with Pre-Diabetes  

MedlinePLUS

Complications to Avoid with Pre-diabetes Updated:Mar 8,2014 If I ignore the pre-diabetes, how could diabetes reduce the quality or length of ... treat one of them, you treat them all. Pre-diabetes Introduction About Pre-diabetes What's the Problem? ...

220

Diabetes Metab Res Rev. Author manuscript Anti-CD38 autoantibodies in type? diabetes  

E-print Network

Diabetes Metab Res Rev. Author manuscript Page /1 12 Anti-CD38 autoantibodies in type? diabetes.mallone@inserm.fr> Abstract Human diabetes mellitus comprises two main clinical entities: type 1 and type 2 diabetes. While type 1 diabetes is autoimmune in origin, type 2 diabetes is due to a decreased sensitivity to insulin

Paris-Sud XI, Université de

221

Atypical diabetes in children: ketosis-prone type 2 diabetes  

PubMed Central

Ketosis-prone type 2 diabetes mellitus also known as atypical or flatbush diabetes is being increasingly recognised worldwide. These patients are typically obese, middle-aged men with a strong family history of type 2 diabetes. The aetiology and pathophysiological mechanism is still unclear but some initial research suggests that patients with ketosis-prone type 2 diabetes have a unique predisposition to glucose desensitisation. These patients have negative autoantibodies typically associated with type 1 diabetes but have shown to have human leucocyte antigen (HLA) positivity. At initial presentation, there is an impairment of both insulin secretion and action. ? Cell function and insulin sensitivity can be markedly improved by initiating aggressive diabetes management to allow for discontinuation of insulin therapy within a few months of treatment. These patients can be maintained on oral hypoglycaemic agents and insulin therapy can be safely discontinued after few months depending on their ? cell function. PMID:23302548

Vaibhav, Atul; Mathai, Mathew; Gorman, Shaun

2013-01-01

222

Menopause and risk of diabetes in the Diabetes Prevention Program  

PubMed Central

Objective The study objective was to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopausal status modifies response to diabetes prevention interventions. Methods The study population included women in premenopause (n=708), natural postmenopause (n=328), and bilateral oophorectomy (n=201) in the Diabetes Prevention Program (DPP), a randomized placebo-controlled trial of lifestyle intervention and metformin among glucose intolerant adults. Associations between menopause and diabetes risk were evaluated using Cox proportional hazard models that adjusted for demographic variables (age, race/ethnicity, family history of diabetes, history of gestational diabetes mellitus), waist circumference, insulin resistance and corrected insulin response. Similar models were constructed after stratification by menopause type and hormone therapy (HT) use. Results After adjustment for age, there was no association between natural menopause or bilateral oophorectomy and diabetes risk. Differences by study arm were observed in women who reported bilateral oophorectomy. In the lifestyle arm, women with bilateral oophorectomy had a lower adjusted hazard for diabetes (HR 0.19, 95% CI 0.04, 0.94), although observations were too few to determine if this was independent of HT use. No significant differences were seen in the metformin (HR 1.29, 95% CI 0.63, 2.64) or placebo arms (HR 1.37, 95% CI 0.74, 2.55). Conclusions Among women at high-risk for diabetes, natural menopause was not associated with diabetes risk and did not affect response to diabetes prevention interventions. In the lifestyle intervention, bilateral oophorectomy was associated with decreased diabetes risk. PMID:21709591

Kim, Catherine; Edelstein, Sharon L.; Crandall, Jill P.; Dabelea, Dana; Kitabchi, Abbas E.; Hamman, Richard F.; Montez, Maria G.; Perreault, Leigh; Foulkes, Mary A.; Barrett-Connor, Elizabeth

2012-01-01

223

Reprogramming diabetic stem or progenitor cells for treating diabetic complications  

Cancer.gov

Bone marrow-derived stem or progenitor cells such as mesenchymal stem cells (MSCs) or endothelial progenitor cells (EPCs) have been shown to be effective for repairing cardiovascular disease. However, recent studies have shown that autologous cells derived from diabetic patients are not as effective as those from non-diabetic or healthy volunteers. As many cardiovascular disease patients who are candidate for cell therapy have diabetes as co-morbid condition, new measures are required to reverse their dysfunction.

224

Diabetic Complications in Obese Type 2 Diabetic Rat Models  

PubMed Central

We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Torii (SDT) fatty rat. Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of ? cells, and degenerative changes, such as islet atrophy and fibrosis of islet with infiltration of inflammatory cells. Renal lesions in tubuli and glomeruli were observed, and nodular lesions in glomeruli were notable changes in OLETF and SDT fatty rats. Among retinal changes, folding and thickening were interesting findings in SDT fatty rats. A decrease of motor nerve conduction velocity with progression of diabetes was presented in obese diabetic rats. Other diabetic complications, osteoporosis and sexual dysfunction, were also observed. Observation of bone metabolic abnormalities, including decrease of osteogenesis and bone mineral density, and sexual dysfunction, including hypotestosteronemia and erectile dysfunction, in obese type 2 diabetic rats have been reported. PMID:24770637

Katsuda, Yoshiaki; Ohta, Takeshi; Miyajima, Katsuhiro; Kemmochi, Yusuke; Sasase, Tomohiko; Tong, Bin; Shinohara, Masami; Yamada, Takahisa

2014-01-01

225

Genetics Home Reference: Permanent neonatal diabetes mellitus  

MedlinePLUS

... literature OMIM Genetic disorder catalog Conditions > Permanent neonatal diabetes mellitus On this page: Description Genetic changes Inheritance ... definitions Reviewed July 2011 What is permanent neonatal diabetes mellitus? Permanent neonatal diabetes mellitus is a type ...

226

Genetics Home Reference: Nephrogenic diabetes insipidus  

MedlinePLUS

... Recent literature OMIM Genetic disorder catalog Conditions > Nephrogenic diabetes insipidus On this page: Description Genetic changes Inheritance ... Glossary definitions Reviewed April 2010 What is nephrogenic diabetes insipidus? Nephrogenic diabetes insipidus is a disorder of ...

227

Genetics Home Reference: Neurohypophyseal diabetes insipidus  

MedlinePLUS

... Recent literature OMIM Genetic disorder catalog Conditions > Neurohypophyseal diabetes insipidus On this page: Description Genetic changes Inheritance ... Glossary definitions Reviewed April 2010 What is neurohypophyseal diabetes insipidus? Neurohypophyseal diabetes insipidus is a disorder of ...

228

Gestational Diabetes: What You Need to Know  

MedlinePLUS

... Info Statistics Research Resources About Us Espaol National Diabetes Information Clearinghouse Publications Tools and Resources E-News ... Gestational Diabetes: What You Need to Know Gestational Diabetes: What You Need to Know On this page: ...

229

JAMA Patient Page: Weight and Diabetes  

MedlinePLUS

... of the American Medical Association JAMA PATIENT PAGE Weight and Diabetes D iabetes is a common disorder ... 2006, issue of JAMA . TO LOSE OR CONTROL WEIGHT FOR MORE INFORMATION American Diabetes Association www.diabetes. ...

230

How Is Diabetic Heart Disease Treated?  

MedlinePLUS

... page from the NHLBI on Twitter. How Is Diabetic Heart Disease Treated? Diabetic heart disease (DHD) is treated with lifestyle changes, ... may recommend a pacemaker or ICD to treat diabetic cardiomyopathy . Other types of surgery also are used ...

231

Tips for Teens with Diabetes: Be Active  

MedlinePLUS

... for Teens with Diabetes: Be Active Download This Publication (NDEP-64) Want this item now? Download it ... or downloaded here . View Entire NDEP Catalog Related Publications Tips for Teens with Diabetes: What is Diabetes? ( ...

232

Take Charge of Your Diabetes (Eye Problems)  

MedlinePLUS

... gov . Diabetes Public Health Resource Share Compartir Take Charge of Your Diabetes Signs of Diabetic Eye Disease ... Theres a lot you can do to take charge and prevent such problems. A recent study shows ...

233

Take Charge of Your Diabetes (Nerve Damage)  

MedlinePLUS

... gov . Diabetes Public Health Resource Share Compartir Take Charge of Your Diabetes Some Signs of Diabetic Nerve ... Theres a lot you can do to take charge and prevent nerve damage. A recent study shows ...

234

Living With Diabetes: Keep Your Feet Healthy  

MedlinePLUS

... Preventing Diabetes Foot Problems. CDC's Division of Diabetes Translation offers more resources: What should I do on ... Disease Prevention and Health Promotion , Division of Diabetes Translation Page maintained by: Office of the Associate Director ...

235

Your Guide to Diabetes: Type 1 and Type 2  

E-print Network

Your Guide to Diabetes: Type 1 and Type 2 National Diabetes Information Clearinghouse #12;#12;Your Guide to Diabetes: Type 1 and Type 2 #12;#12;Contents Learn about Diabetes ............................................................ 1 What is diabetes? .............................................................. 2 What

Rau, Don C.

236

Matters of the Heart: Support a Loved One with Diabetes  

MedlinePLUS

... of the Heart: Support a Loved One with Diabetes By the National Diabetes Education Program Diabetes is ... a stroke, or other problems. Understand your sweethearts diabetes . Each persons experience with diabetes is different. Learn ...

237

Neonatal Diabetes Mellitus  

PubMed Central

An explosion of work over the last decade has produced insight into the multiple hereditary causes of a nonimmunological form of diabetes diagnosed most frequently within the first 6 months of life. These studies are providing increased understanding of genes involved in the entire chain of steps that control glucose homeostasis. Neonatal diabetes is now understood to arise from mutations in genes that play critical roles in the development of the pancreas, of ?-cell apoptosis and insulin processing, as well as the regulation of insulin release. For the basic researcher, this work is providing novel tools to explore fundamental molecular and cellular processes. For the clinician, these studies underscore the need to identify the genetic cause underlying each case. It is increasingly clear that the prognosis, therapeutic approach, and genetic counseling a physician provides must be tailored to a specific gene in order to provide the best medical care. PMID:18436707

Aguilar-Bryan, Lydia; Bryan, Joseph

2008-01-01

238

LiquichekTM Diabetes Control  

E-print Network

LiquichekTM Diabetes Control Bio-Rad Laboratories D I A B E T E S / H E M O G L O B I N C O N T R O L S #12;LiquichekTM Diabetes Control Hemoglobin A1C Hemoglobin, Total A liquid human whole blood based product designed to monitor the performance of hemoglobin tests associated with diabetes

Rodriguez, Carlos

239

Childhood Diabetes: A Global Perspective  

Microsoft Academic Search

Diabetes is an evolving disease, with changing patterns seen in both type 1 and type 2 diabetes. A wide (over 400-fold) variation exists in worldwide incidence rates of type 1 diabetes, with the highest occurring in Finland (over 45 per 100,000 under the age of 15 years) and the lowest in parts of China. In many countries (e.g. in Europe,

Martin Silink

2002-01-01

240

Novel therapies in diabetes mellitus.  

PubMed

The 42nd annual meeting of the European Association for the Study of Diabetes (EASD) was held in Copenhagen-Malmo, September 14-17, 2006. This scientific program brought together international panels of speakers who discussed recent advances in epidemiology, genetics, pathophysiology and emerging therapeutic strategies in diabetes mellitus and related disorders. This article focuses on a broad range of new therapeutic possibilities and advances in the management of diabetes mellitus. PMID:17160152

Bandyopadhyay, Prabirkumar

2006-10-01

241

Osteocalcin levels in diabetic subjects  

Microsoft Academic Search

SummaryBecause a series of reports suggests the existence of altered bone and mineral metabolism in diabetes mellitus, we studied\\u000a 106 diabetic subjects (42 insulin-dependent (IDD) and 64 noninsulin dependent (NIDD)) to determine whether a difference in\\u000a bone turnover (evaluated by serum osteocalcin (OC)) could be found in comparison with normal controls. OC levels in diabetic\\u000a subjects were lower than the

M. Pedrazzoni; G. Ciotti; G. Pioli; G. Girasole; L. Davoli; E. Palummeri; Mario Passeri

1989-01-01

242

Metformin and gestational diabetes  

Microsoft Academic Search

Pregnancy increases requirements for insulin secretion, increasing insulin resistance and demands on pancreatic ? cells, promoting\\u000a development of gestational diabetes (GD), particularly in women with preexisting insulin resistance, commonly in women with\\u000a polycystic ovary syndrome. Preliminary studies suggest that metformin may have the unique potential to prevent the development\\u000a of GD. We postulate that interventions that reduce insulin resistance and

Charles J. Glueck; Naila Goldenberg; Patricia Streicher; Ping Wang

2003-01-01

243

Subacute diabetic proximal neuropathy  

NASA Technical Reports Server (NTRS)

OBJECTIVE: To evaluate the clinical, electrophysiologic, autonomic, and neuropathologic characteristics and the natural history of subacute diabetic proximal neuropathy and its response to immunotherapy. MATERIAL AND METHODS: For the 12-year period from 1983 to 1995, we conducted a retrospective review of medical records of Mayo Clinic patients with diabetes who had subacute onset and progression of proximal weakness. The responses of treated versus untreated patients were compared statistically. RESULTS: During the designated study period, 44 patients with subacute diabetic proximal neuropathy were encountered. Most patients were middle-aged or elderly, and no sex preponderance was noted. The proximal muscle weakness often was associated with reduced or absent lower extremity reflexes. Associated weight loss was a common finding. Frequently, patients had some evidence of demyelination on nerve conduction studies, but it invariably was accompanied by concomitant axonal degeneration. The cerebrospinal fluid protein concentration was usually increased. Diffuse and substantial autonomic failure was generally present. In most cases, a sural nerve biopsy specimen suggested demyelination, although evidence of an inflammatory infiltrate was less common. Of 12 patients who received treatment (with prednisone, intravenous immune globulin, or plasma exchange), 9 had improvement of their conditions, but 17 of 29 untreated patients (59%) with follow-up also eventually had improvement, albeit at a much slower rate. Improvement was usually incomplete. CONCLUSION: We suggest that the entity of subacute diabetic proximal neuropathy is an extensive and severe variant of bilateral lumbosacral radiculoplexopathy, with some features suggestive of an immune-mediated cause. It differs from chronic inflammatory demyelinating polyradiculoneuropathy in that most cases have a more restricted distribution and seem to be monophasic and self-limiting. The efficacy of immunotherapy is unproved, but such intervention may be considered in the severe and progressive cases or ones associated with severe neuropathic pain.

Pascoe, M. K.; Low, P. A.; Windebank, A. J.; Litchy, W. J.

1997-01-01

244

Hypoglycemia in diabetics.  

PubMed

Hypoglycemia in diabetes can be divided into 1) spontaneous hypoglycemic reactions due to absolute or relative overproduction of endogenous insulin or some other blood glucose-lowering substance, as in islet cell adenoma or carcinoma, latent or protodiabetic conditions, (extrapancreatic) tumors and pituitary and/or adrenal disorders; and 2) hypoglycemia caused by exogenous, i.e. therapeutic, measures. The problem of hypoglycemia in insulin-treated diabetics is far from being solved. As revealed by continuous blood glucose monitoring, nocturnal hypoglycemic attacks frequently escape attention especially in juvenile diabetics. Circadian variations in peripheral glucose utilization, rather than changes in plasma insulin activity, are likely to be involved in this mechanism. At least, this was the conclusion drawn from studies carried out by means of a glucose-controlled insulin and glucose infusion system (GCIGIS) -or artificial pancreas-which delivers short-acting insulin and glucose on demand intravenously. Hypoglycemic reactions in patients being treated with oral anti-diabetic agents, on the other hand, should be regarded primarily as one of the side reactions intrinsic to the mechanism of action of some of these drugs, e.g. sulfonylureas, which act mainly via stimulation of secretion of endogenous insulin reserves not responding properly to postprandial blood glucose increments. In the case of glibenclamide, at least partial resensitization of the defective glucose receptor of the beta-cell also becomes operative. A higher incidence of a characteristic type of hypoglycemic reaction was observed soon after glibenclamide therapy was introduced. Better understanding of the drug and dissemination of the information about it to doctors and patients has reduced the number of hypoglycemic reactions caused by glibenclamide to the same proportions as for other sulfonylureas. Hypoglyoemia following therapeutic hypophysectomy retains its position as one of the main hazards of this heroic therapy. PMID:179924

Pfeiffer, E F; Thum, C; Raptis, S; Beischer, W; Ziegler, R

1976-01-01

245

Do Well, Be Well with Diabetes  

E-print Network

Do Well, Be Well with Diabetes Do Well, Be Well with Diabetes Lesson Topics ·WhatisDiabetes? ·Nutrition­FirstSteptoDiabetesManagement ·OneDiabetesDiet­NoLongertheSoleOption ·ManagingYourBloodGlucose ·NutritionalLabels ·DiabetesandExercise ·ForGoodMeasureatHomeandEatingOut ·DiabetesMedicines ·Preventingand

246

Diabetic nephropathy and antioxidants  

PubMed Central

Context Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients. Evidence Acquisitions Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Results Treatment of DN in human are insufficient with rennin angiotensin system (RAS) blockers, so additional agent ought to combine with this management. Meanwhile based on DN pathogenesis and evidences in experimental and human researches, the antioxidants are the best candidate. New multi-property antioxidants may be improved human DN that show high power antioxidant capacity, long half-life time, high permeability to mitochondrion, improve body antioxidants enzymes activity and anti-inflammatory effects. Conclusions Based on this review and our studies on diabetic rats, rosmarinic acid a multi-property antioxidant may be useful in DN patients, but of course, needs to be proven in clinical trials studies. PMID:24475422

Tavafi, Majid

2013-01-01

247

New Concepts in Diabetic Embryopathy  

PubMed Central

Synopsis Diabetes mellitus is responsible for nearly 10% of fetal anomalies in diabetic pregnancies. Although aggressive perinatal care and glycemic control are available in developed countries, the birth defect rate in diabetic pregnancies remains much higher than that in the general population. Major cellular activities--i.e., proliferation and apoptosis--and intracellular metabolic conditions--i.e., nitrosative, oxidative, and endoplasmic reticulum stress--have been demonstrated to be associated with diabetic embryopathy using animal models. Translating advances made in animal studies into clinical applications in humans will require collaborative efforts across the basic research, preclinical, and clinical communities. PMID:23702113

Reece, E. Albert

2013-01-01

248

Gallbladder function in diabetic patients  

SciTech Connect

Gallbladder emptying and filling was studied in eight diabetic and six normal control patients. None of the patients had gallstones. Cholescintigraphy was performed using (/sup 99m/Tc)disofenin, and gallbladder emptying was studied using a 45-min i.v. infusion of the octapeptide of cholecystokinin (OP-CCK) 20 ng/kg X hr. The peak filling rate was greater in diabetic than in normal subjects; however, emptying of the gallbladder in response to OP-CCK was significantly less in the diabetic subjects (51.6 +/- 10.4% compared with 77.2 +/- 4.9%). When the diabetic group was subdivided into obese and nonobese diabetics, the obese diabetics had a much lower percentage of emptying than the nonobese diabetics (30.0 +/- 10.4% compared with 73.1 +/- 9.3%). These findings suggest that obese diabetics may have impaired emptying of the gallbladder even in the absence of gallstones. The more rapid rate of gallbladder filling in obesity may indicate hypotonicity of the gallbladder. The combination of these abnormalities may predispose the obese diabetic to the development of gallstones.

Shreiner, D.P.; Sarva, R.P.; Van Thiel, D.; Yingvorapant, N.

1986-03-01

249

Help Prevent Diabetes with Exercise  

NSDL National Science Digital Library

This animated video segment adapted from the Centers for Disease Control and Prevention, featuring American Indian characters, explains how children can help prevent diabetes through regular physical activity.

Foundation, Wgbh E.

2011-07-01

250

Epidemiology, Mechanisms and Management of Diabetic Gastroparesis  

PubMed Central

Background Recent evidence of the significant impact of gastroparesis on morbidity and mortality mandates optimized management of this condition. Gastroparesis affects nutritional state and, in diabetics, it also has deleterious effects on glycemic control and secondary effects on organs that lead to increased mortality. First-line treatment includes restoration of nutrition and medications (prokinetic and antiemetic). Aim To review the epidemiology, pathophysiology, impact, natural history, time trends and treatment of gastroparesis with particular focus on diabetic gastroparesis. Methods The pros and cons of current treatment options including metoclopramide are discussed. Second-line approaches include surgery, venting gastrostomy or jejunostomy, and gastric electrical stimulation; most of these treatments are based on open-label treatment trials. Results/Conclusions In the future, drugs that target the underlying defects and new prokinetics such as newer 5-HT4 agonists (which appear to be devoid of cardiac or vascular effects), ghrelin agonists, new approaches to pacing the stomach, and stem cell therapies may bring more effective treatments to ameliorate the management of patients with gastroparesis. PMID:20951838

Camilleri, Michael; Bharucha, Adil E.; Farrugia, Gianrico

2010-01-01

251

[Factors associated with increased diabetes burden in elderly diabetic patients].  

PubMed

To define the factors that determine the increased burden of diabetes in elderly diabetic patients, we examined the relationship between the Elderly Diabetes Impact Scales (EDIS) and physical or social factors in 383 elderly outpatients aged over 60 years old who answered QOL questionnaires by professional interviewers. The EDIS consisted of 6 subscales (burden of symptoms, burden of daily life, burden of diet therapy, burden of drug therapy, satisfaction, worry) and total EDIS scores were calculated by summing up the 4-point scores of 37 questions. The EDIS scores were highest in patients who received insulin therapy. In univariate analysis, high EDIS scores were significantly associated with high HbA1c, low Roken ADL score, and the presence of retinopathy or neuropathy. Among social factors, leisure activities, housework or jobs, social network, and positive social support were significantly associated with low EDIS scores, while negative social support was associated with high EDIS scores in elderly diabetic patients. Multiple linear regression analysis revealed that age (younger), sex (women), low ADL (or diabetic complications), insulin therapy, low positive social support, high negative social support, economical dissatisfaction, and the low adaptative feeling of diabetes were significant and independent determinants of a high burden in diabetic patients indicated by EDIS scores in Japanese elderly diabetic patients. PMID:8865740

Araki, A; Izumo, Y; Inoue, J; Takahashi, R; Takanashi, K; Teshima, T; Yatomi, N; Shimizu, Y; Ito, H

1995-12-01

252

DIABETES MELLITUS COMO FACTOR DE RIESGO DE DEMENCIA EN LA POBLACIN ADULTA MAYOR MEXICANA  

PubMed Central

Introduccion La diabetes mellitus y las demencias constituyen dos problemas crecientes de salud entre la poblacin adulta mayor del mundo y en particular de los paises en desarrollo. Hacen falta estudios longitudinales sobre el papel de la diabetes como factor de riesgo para demencia. Objetivo Determinar el riesgo de demencia en sujetos Mexicanos con diabetes mellitus tipo 2. Materiales y Metodos Los sujetos diabticos libres de demencia pertenecientes al Estudio Nacional de Salud y Envejecimiento en Mxico fueron evaluados a los dos aos de la lnea de base. Se estudi el papel de los factores sociodemogrficos, de otras comorbilidades y del tipo de tratamiento en la conversin a demencia. Resultados Durante la lnea de base 749 sujetos (13.8%) tuvieron diabetes. El riesgo de desarrollar demencia en estos individuos fue el doble (RR, 2.08 IC 95%, 1.592.73). Se encontr un riesgo mayor en individuos de 80 aos y ms (RR 2.44 IC 95%, 1.464.08), en los hombres (RR, 2.25 IC 95%, 1.463.49) y en sujetos con nivel educativo menor de 7 aos. El estar bajo tratamiento con insulina increment el riesgo de demencia (RR, 2.83, IC 95%, 1.585.06). Las otras comorbilidades que aumentaron el riesgo de demencia en los pacientes diabticos fueron la hipertensin (RR, 2.75, IC 95%, 1.864.06) y la depresin (RR, 3.78, 95% IC 2.376.04). Conclusin Los sujetos con diabetes mellitus tienen un riesgo mayor de desarrollar demencia, La baja escolaridad y otras comorbilidades altamente prevalentes en la poblacin Mexicana contribuyen a la asociacin diabetes-demencia. PMID:21948010

Silvia, Meja-Arango; Clemente, y Ziga-Gil

2012-01-01

253

Juvenile Diabetes and Rehabilitation Counseling.  

ERIC Educational Resources Information Center

Severe complications of diabetes are more likely to occur with the juvenile diabetic and problems of psychosocial adjustment are recurring and difficult. Implications for the rehabilitation counselor are discussed in terms of employment considerations, the effects of complications, genetic counseling, and cooperation with other professionals.

Stone, J. Blair; Gregg, Charles H.

1981-01-01

254

Diabetes and contact lens wear.  

PubMed

The literature suggests that diabetic patients may have altered tear chemistry and tear secretion as well as structural and functional changes to the corneal epithelium, endothelium and nerves. These factors, together with a reported increased incidence of corneal infection, suggest that diabetic patients may be particularly susceptible to developing ocular complications during contact lens wear. Reports of contact lens-induced complications in diabetic patients do exist, although a number of these reports concern patients with advanced diabetic eye disease using lenses on an extended wear basis. Over the past decade or so, there have been published studies documenting the response of the diabetic eye to more modern contact lens modalities. The results of these studies suggest that contact lenses can be a viable mode of refractive correction for diabetic patients. Furthermore, new research suggests that the measurement of tear glucose concentration could, in future, be used to monitor metabolic control non-invasively in diabetic patients. This could be carried out using contact lenses manufactured from hydrogel polymers embedded with glucose-sensing agents or nanoscale digital electronic technology. The purpose of this paper is to review the literature on the anterior ocular manifestations of diabetes, particularly that pertaining to contact lens wear. PMID:22537249

O'Donnell, Clare; Efron, Nathan

2012-05-01

255

Morgan: A Case of Diabetes  

NSDL National Science Digital Library

This case teaches about the causes and effects of Type 2 diabetes by working through the various options available to a young Native American woman suffering from the disease. The case can be used in a variety of settings, including nutrition classrooms, herbal drug courses, physiology courses, medical schools, nursing schools, pharmacy schools, diabetes workshops, and even weight loss clinics.

Rubin, Lisa M.; Herreid, Clyde F.

2002-01-01

256

Calcium signaling in diabetic cardiomyocytes.  

PubMed

Diabetes mellitus is one of the most common medical conditions. It is associated to medical complications in numerous organs and tissues, of which the heart is one of the most important and most prevalent organs affected by this disease. In fact, cardiovascular complications are the most common cause of death among diabetic patients. At the end of the 19th century, the weakness of the heart in diabetes was noted as part of the general muscular weakness that exists in that disease. However, it was only in the eighties that diabetic cardiomyopathy was recognized, which comprises structural and functional abnormalities in the myocardium in diabetic patients even in the absence of coronary artery disease or hypertension. This disorder has been associated with both type 1 and type 2 diabetes, and is characterized by early-onset diastolic dysfunction and late-onset systolic dysfunction, in which alteration in Ca(2+) signaling is of major importance, since it controls not only contraction, but also excitability (and therefore is involved in rhythmic disorder), enzymatic activity, and gene transcription. Here we attempt to give a brief overview of Ca(2+) fluxes alteration reported on diabetes, and provide some new data on differential modulation of Ca(2+) handling alteration in males and females type 2 diabetic mice to promote further research. Due to space limitations, we apologize for those authors whose important work is not cited. PMID:25205537

Pereira, Laetitia; Ruiz-Hurtado, Gema; Rueda, Anglica; Mercadier, Jean-Jacques; Benitah, Jean-Pierre; Gmez, Ana Mara

2014-11-01

257

Diabetes as Experienced by Adolescents.  

ERIC Educational Resources Information Center

Explored adolescents' perspective of their diabetic management by interviewing 12 adolescent counselors-in-training at a diabetic youth camp. Interviews were analyzed using the constant comparative method; themes were further grouped into three categories: psychosocial, developmental, and clinical. A striking finding throughout the data was the

Meldman, Linda S.

1987-01-01

258

Skin manifestations in diabetes mellitus.  

PubMed

Background: Diabetes mellitus affects all systems of the body. Skin is also frequently involved. The aim of the study was to assess the frequency of various skin manifestations in patients with diabetes mellitus. Methods: This descriptive study was conducted at the out-patient diabetic clinics at Aga Khan University Hospital, Karachi. One hundred consecutive patients, both male and female suffering from either type-1 or type-2 diabetes mellitus were included. Results: Out of hundred patients, skin changes were present in 84% of patients. The most frequent finding was skin infections present in 29.7% of patients and the second most common finding was diabetic dermopathy found in 28.5% of patients. Other finding were: Acanthosis Nigricans in 19%, sweating complications in 14.2%, nail involvement in 10.7%, oral involvenient in 5.9%, diabetic foot in 5.9%, xanthelasma in 4.7%, yellow skin in 1.1%, generalized Pruritus in 1.1%, limited joint mobility in 1.1%. Conclusion: The cutaneous manifestations are very common in our diabetic patients (84%) and it is important that they are identified and appropriately treated in diabetes follow up clinics. PMID:25358216

Furqan, Saira; Kamani, Lubna; Jabbar, Abdul

2014-01-01

259

Exercise and Type 2 Diabetes  

PubMed Central

Although physical activity (PA) is a key element in the prevention and management of type 2 diabetes, many with this chronic disease do not become or remain regularly active. High-quality studies establishing the importance of exercise and fitness in diabetes were lacking until recently, but it is now well established that participation in regular PA improves blood glucose control and can prevent or delay type 2 diabetes, along with positively affecting lipids, blood pressure, cardiovascular events, mortality, and quality of life. Structured interventions combining PA and modest weight loss have been shown to lower type 2 diabetes risk by up to 58% in high-risk populations. Most benefits of PA on diabetes management are realized through acute and chronic improvements in insulin action, accomplished with both aerobic and resistance training. The benefits of physical training are discussed, along with recommendations for varying activities, PA-associated blood glucose management, diabetes prevention, gestational diabetes mellitus, and safe and effective practices for PA with diabetes-related complications. PMID:21115758

Colberg, Sheri R.; Sigal, Ronald J.; Fernhall, Bo; Regensteiner, Judith G.; Blissmer, Bryan J.; Rubin, Richard R.; Chasan-Taber, Lisa; Albright, Ann L.; Braun, Barry

2010-01-01

260

Insulin dependent diabetes in Asians.  

PubMed Central

Type 1 diabetes is said to be extremely rare in children in India, where diabetes treated with insulin may be due to chronic pancreatic disease or malnutrition. To see whether typical type 1 diabetes occurred in Asian children in the United Kingdom, all known Asian children with diabetes in industrial West Yorkshire were ascertained. A total of 17 such children were studied; of these, seven were from three multiplex families and two fathers from these families had diabetes. All children were ketosis prone and developed diabetes while resident in the UK. There were significant increases in HLA-B8 and HLA-DR3 and increases in HLA-DR4 and HLA-DR3/DR4, while HLA-B15 was absent. Islet cell antibodies, either IgG or complement fixing, were present in four of 18 subjects tested, all of whom had disease of short duration. The prevalence of type 1 diabetes in Asian children aged 15 years or less in West Yorkshire was 36/100,000, assuming complete ascertainment. It is concluded that typical type 1 diabetes may occur in Asian children and this condition may be more common in families who have migrated to the UK. PMID:3494431

Bodansky, H J; Beverley, D W; Gelsthorpe, K; Saunders, A; Bottazzo, G F; Haigh, D

1987-01-01

261

Spices and type 2 diabetes  

Microsoft Academic Search

Purpose The paper is a review of current research on phytochemicals and how they may alleviate type 2 diabetes by improving insulin activity in the body. Design\\/methodology\\/approach Literature searches were conducted to find a link between common household spices and type 2 diabetes. Only common household spices were researched so that any link found between spices and type

Abigail Kelble

2005-01-01

262

Commissioning specialist diabetes services for adults with diabetes: summary of a Diabetes UK Task and Finish group report.  

PubMed

The increasing prevalence of diabetes, the drive to develop community services for diabetes and the Quality and Outcomes Framework for diabetes have led to improvements in the management of diabetes in primary care settings, with services traditionally provided only in specialist care now provided for many patients with diabetes by non-specialists. Consequently, there is a need to redefine roles, responsibilities and components of a specialist diabetes service to provide for the needs of patients in the National Health Service (NHS) today. The delivery of diabetes care is complex and touches on almost every aspect of the health service. It is the responsibility of those working within commissioning and specialist provider roles to work together with people with diabetes to develop, organize and deliver a full range of integrated diabetes care services. The local delivery model agreed within the local diabetes network, comprising specialist teams, primary care teams, commissioners and people with diabetes, should determine how the diabetes specialist services are organizsed. It should identify the roles and responsibilities of provider organizations to ensure that the right person provides the right care, at the right time, and in the right place. We summarize a report entitled 'Commissioning Diabetes Specialist Services for Adults with Diabetes', which has been produced, as a 'Task and Finish' group activity within Diabetes UK, to assist managers, commissioners and healthcare professionals to provide advice on the structure, roles and components of specialist diabetes services for adults. PMID:21838769

Goenka, N; Turner, B; Vora, J

2011-12-01

263

Pathogenesis of Painful Diabetic Neuropathy  

PubMed Central

The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. It has a huge effect on a person's daily life, both physically and mentally. Despite huge advances in diabetes and neurology, the exact mechanism of pain causation in PDN is still not clear. The origin of pain could be in the peripheral nerves of the central nervous system. In this review, we discuss various possible mechanisms of the pathogenesis of pain in PDN. We discuss the role of hyperglycaemia in altering the physiology of peripheral nerves. We also describe central mechanisms of pain. PMID:24891949

Rajbhandari, Satyan

2014-01-01

264

The diabetic patient in Ramadan.  

PubMed

During the month of Ramadan, all healthy, adult Muslims are required to fast from dawn to sunset. Fasting during Ramadan involves abstaining from food, water, beverages, smoking, oral drugs, and sexual intercourse. Although the Quran exempts chronically ill from fasting, many Muslims with diabetes still fast during Ramadan. Patients with diabetes who fast during the month of Ramadan can have acute complications. The risk of complications in fasting individuals with diabetes increases with longer periods of fasting. All patients with diabetes who wish to fast during Ramadan should be prepared by undergoing a medical assessment and engaging in a structured education program to undertake the fast as safely as possible. Although some guidelines do exist, there is an overwhelming need for better designed clinical trials which could provide us with evidence-based information and guidance in the management of patients with diabetes fasting Ramadan. PMID:24761380

Chamsi-Pasha, Hassan; Aljabri, Khalid S

2014-04-01

265

Diabetes mellitus and electrolyte disorders  

PubMed Central

Diabetic patients frequently develop a constellation of electrolyte disorders. These disturbances are particularly common in decompensated diabetics, especially in the context of diabetic ketoacidosis or nonketotic hyperglycemic hyperosmolar syndrome. These patients are markedly potassium-, magnesium- and phosphate-depleted. Diabetes mellitus (DM) is linked to both hypo- and hyper-natremia reflecting the coexistence of hyperglycemia-related mechanisms, which tend to change serum sodium to opposite directions. The most important causal factor of chronic hyperkalemia in diabetic individuals is the syndrome of hyporeninemic hypoaldosteronism. Impaired renal function, potassium-sparing drugs, hypertonicity and insulin deficiency are also involved in the development of hyperkalemia. This article provides an overview of the electrolyte disturbances occurring in DM and describes the underlying mechanisms. This insight should pave the way for pathophysiology-directed therapy, thus contributing to the avoidance of the several deleterious effects associated with electrolyte disorders and their treatment. PMID:25325058

Liamis, George; Liberopoulos, Evangelos; Barkas, Fotios; Elisaf, Moses

2014-01-01

266

Diabetes mellitus and electrolyte disorders.  

PubMed

Diabetic patients frequently develop a constellation of electrolyte disorders. These disturbances are particularly common in decompensated diabetics, especially in the context of diabetic ketoacidosis or nonketotic hyperglycemic hyperosmolar syndrome. These patients are markedly potassium-, magnesium- and phosphate-depleted. Diabetes mellitus (DM) is linked to both hypo- and hyper-natremia reflecting the coexistence of hyperglycemia-related mechanisms, which tend to change serum sodium to opposite directions. The most important causal factor of chronic hyperkalemia in diabetic individuals is the syndrome of hyporeninemic hypoaldosteronism. Impaired renal function, potassium-sparing drugs, hypertonicity and insulin deficiency are also involved in the development of hyperkalemia. This article provides an overview of the electrolyte disturbances occurring in DM and describes the underlying mechanisms. This insight should pave the way for pathophysiology-directed therapy, thus contributing to the avoidance of the several deleterious effects associated with electrolyte disorders and their treatment. PMID:25325058

Liamis, George; Liberopoulos, Evangelos; Barkas, Fotios; Elisaf, Moses

2014-10-16

267

[Insomnia disorder comorbid with diabetes].  

PubMed

Insomnia disorder is one of the most prevalent conditions comorbid with diabetes and has been shown to have a possible role in the development of diabetes. Insomnia is characterized by a state of excessive physiological and cognitive arousal with alterations in autonomic and hypothalamic-pituitary-adrenal function. The chronic neuroendocrine activation in insomnia may predispose insomniacs to the development of metabolic disorders including glucose intolerance. In contrast, diabetic complications, in combination with the disruption of a sleep-wake homeostatic and circadian process, can be key factors precipitating insomnia symptoms and involve several subtypes of insomnia. Furthermore, inappropriate lifestyles are also likely responsible for the exacerbation of insomnia and diabetes. Thus, the pathogenesis of insomnia disorder and diabetes could mutually interact to develop each disease with a vicious cycle, accounting for the high comorbidity between the diseases. PMID:24912303

Kadono, Mayuko; Hasegawa, Goji

2014-05-01

268

I-E+ nonobese diabetic mice develop insulitis and diabetes  

PubMed Central

The development of type I diabetes in the nonobese diabetic (NOD) mouse is under the control of multiple genes, one or more of which is linked to the major histocompatibility complex (MHC). The MHC class II region has been implicated in disease development, with expression of an I-E transgene in NOD mice shown to provide protection from insulitis and diabetes. To examine the effect of expressing an I-E+ or I-E- non-NOD MHC on the NOD background, three I-E+ and three I-E- NOD MHC congenic strains (NOD.H-2i5, NOD.H-2k, and NOD.H-2h2, and NOD.H-2h4, NOD.H-2i7, and NOD.H-2b, respectively) were developed. Of these strains, both I-E+ NOD.H-2h2 and I-E- NOD.H-2h4 mice developed insulitis, but not diabetes. The remaining four congenic strains were free of insulitis and diabetes. These results indicate that in the absence of the NOD MHC, diabetes fails to develop. Each NOD MHC congenic strain was crossed with the NOD strain to produce I-E+ and I-E- F1 mice; these mice thus expressed one dose of the NOD MHC and one dose of a non-NOD MHC on the NOD background. While a single dose of a non-NOD MHC provided a large degree of disease protection to all of the F1 strains, a proportion of I-E+ and I-E- F1 mice aged 5-12 mo developed insulitis and cyclophosphamide-induced diabetes. When I-E+ F1 mice were aged 9-17 mo, spontaneous diabetes developed as well. These data are the first to demonstrate that I-E+ NOD mice develop diabetes, indicating that expression of I-E in NOD mice is not in itself sufficient to prevent insulitis or diabetes. In fact, I-E- F1 strains were no more protected from diabetes than I-E+ F1 strains, suggesting that other non-NOD MHC- linked genes are important in protection from disease. Finally, transfer of NOD bone marrow into irradiated I-E+ F1 recipients resulted in high incidences of diabetes, indicating that expression of non-NOD MHC products in the thymus, in the absence of expression in bone marrow- derived cells, is not sufficient to provide protection from diabetes. PMID:8350054

1993-01-01

269

[Diabetic retinopathy in insulin-dependent diabetes mellitus at time of diagnosis].  

PubMed

Diabetic retinopathy is one of the diabetic microangiopathy complications generally occurring after insulin-dependent diabetes has evolved for a few years. We report a 27-year-old woman with severe nonproliferative diabetic retinopathy discovered at the time of insulin-dependent diabetes diagnosis. Argon laser photocoagulation of retinal ischemic territories was initiated. The disease progressed to proliferative diabetic retinopathy. Diabetic retinopathy incidence, onset and severity in insulin-dependent diabetics is discussed. Systematic ophthalmic examination seems necessary at the onset of insulin-dependent or non-insulin-dependent diabetes. PMID:13130263

Zghal-Mokni, I; Jeddi, A; Malouche, N; Hadj Alouane, W; Gaigi, S; Ayed, S

2003-09-01

270

Diabetes and Cognition.  

PubMed

Dementia is a major cause of disability and death among older adults. Those with type 2 diabetes (T2D) are 50-100% more likely to develop dementia than those without T2D, but it is unknown whether this association reflects a causal relationship. Proposed mechanisms through which T2D could cause dementia include the effects of insulin dysregulation and chronic hyperglycemia on features of Alzheimer's disease and macrovascular and microvascular disorders in the brain. More research is needed to elucidate the link between T2D and dementia and identify strategies to maintain cognitive function among people with T2D. PMID:25453304

Mayeda, Elizabeth Rose; Whitmer, Rachel A; Yaffe, Kristine

2015-02-01

271

Diabetic Macular Edema  

NASA Astrophysics Data System (ADS)

The optical coherence tomography (OCT), a noninvasive and noncontact diagnostic method, was introduced in 1995 for imaging macular diseases. In diabetic macular edema (DME), OCT scans show hyporeflectivity, due to intraretinal and/or subretinal fluid accumulation, related to inner and/or outer blood-retinal barrier breakdown. OCT tomograms may also reveal the presence of hard exudates, as hyperreflective spots with a shadow, in the outer retinal layers, among others. In conclusion, OCT is a particularly valuable diagnostic tool in DME, helpful both in the diagnosis and follow-up procedure.

Lobo, Conceio; Pires, Isabel; Cunha-Vaz, Jos

272

Managing diabetes in dialysis patients.  

PubMed

Burgeoning levels of diabetes are a major concern for dialysis services, as diabetes is now the most common cause of end-stage renal disease in most developed nations. With the rapid rise in diabetes prevalence in developing countries, the burden of end stage renal failure due to diabetes is also expected to rise in such countries. Diabetic patients on dialysis have a high burden of morbidity and mortality, particularly from cardiovascular disease, and a higher societal and economic cost compared to non-diabetic subjects on dialysis. Tight glycaemic and blood pressure control in diabetic patients has an important impact in reducing risk of progression to end stage renal disease. The evidence for improving glycaemic control in patients on dialysis having an impact on mortality or morbidity is sparse. Indeed, many factors make improving glycaemic control in patients on dialysis very challenging, including therapeutic difficulties with hypoglycaemic agents, monitoring difficulties, dialysis strategies that exacerbate hyperglycaemia or hypoglycaemia, and possibly a degree of therapeutic nihilism or inertia on the part of clinical diabetologists and nephrologists. Standard drug therapy for hyperglycaemia (eg, metformin) is clearly not possible in patients on dialysis. Thus, sulphonylureas and insulin have been the mainstay of treatment. Newer therapies for hyperglycaemia, such as gliptins and glucagon-like peptide-1 analogues have become available, but until recently, renal failure has precluded their use. Newer gliptins, however, are now licensed for use in 'severe renal failure', although they have yet to be trialled in dialysis patients. Diabetic patients on dialysis have special needs, as they have a much greater burden of complications (cardiac, retinal and foot). They may be best managed in a multidisciplinary diabetic-renal clinic setting, using the skills of diabetologists, nephrologists, clinical nurse specialists in nephrology and diabetes, along with dietitians and podiatrists. PMID:22282737

O'Toole, Sam M; Fan, Stanley L; Yaqoob, M Magdi; Chowdhury, Tahseen A

2012-03-01

273

Tips for Teens with Diabetes: Dealing with the Ups and Downs of Diabetes  

MedlinePLUS

... and Downs of Diabetes Tips for Teens with Diabetes: Dealing With the Ups and Downs of Diabetes Download This Publication (NDEP-81) Want this item now? Download it here: Tips for Teens with Diabetes: Dealing With the Ups and Downs of Diabetes - ...

274

What is Diabetes? Diabetes is a disease that causes you to have high blood sugar.  

E-print Network

What is Diabetes? Diabetes is a disease that causes you to have high blood sugar. DIABETES IS HIGH BLOOD SUGAR We all have sugar in our blood. When you have diabetes you have too much sugar in your blood muscles can then use sugar for fuel. Insulin keeps blood sugar in balance. #12; If you have diabetes

275

Diabetes Care. Author manuscript Hyperglycemia, type 2 diabetes, and depressive symptoms: the British  

E-print Network

Diabetes Care. Author manuscript Page /1 5 Hyperglycemia, type 2 diabetes, and depressive symptoms calixte cavalier 34093 MONTPELLIER CEDEX 5,FR Steno Diabetes Center9 Steno Diabetes Center, Gentofte suggestion that impaired fasting glucose may protect against depression, whereas a diagnosis of diabetes

Paris-Sud XI, Université de

276

The Harold Schnitzer Diabetes Health Center Type 1 Diabetes Support Group  

E-print Network

The Harold Schnitzer Diabetes Health Center Type 1 Diabetes Support Group Our support group is dedicated to adults of all ages (16 years and older) with type 1 diabetes. Each month most our time will be for sharing and a professional from our diabetes center will present a short diabetes-related topic

Chapman, Michael S.

277

Can inaccuracy of reported parental history of diabetes explain the maternal transmission hypothesis for diabetes?  

Microsoft Academic Search

Background The mode of inheritance of type 2 diabetes mellitus is still under discussion. Several studies have suggested an excess maternal transmission, however, more recent studies could not always confirm these findings. Methods We investigated the frequency of a maternal and paternal history of diabetes among diabetic and non-diabetic subjects and assessed the association between diabetes and a parental history

Barbara Thorand; Angela D Liese; Marie-Hlne Metzger; Peter Reitmeir; Andrea Schneidera; Hannelore Lwela

2001-01-01

278

Entrevista con Enrique Buenaventura  

E-print Network

, era muy terrible ya, realmente muy feroz, esta escalada somocista. En tonces, la respuesta tambin fue tan firme que empez a desmoralizar a la Guardia. Te contar un caso. En Masalla, en el mercado, las vendedoras nos contaron cmo se haba... refugiado all la Guardia, muy bien armada, con mucho parque y resultaba muy difcil sacarla de all. Entonces las mismas mujeres del mercado, que haba sido anteriormente bombardeado, salieron en grupo y fueron a tocar a la puerta donde estaba metida la...

Dí ez, Luys A.

1981-04-01

279

with Diabetes Dining A Program For  

E-print Network

with Diabetes Dining A Program For People With Diabetes And Their Families Pre to anyone with diabetes, and their family members or caregivers. Classes will include demonstrations on how. There will be an opportunity to taste a variety of main dishes, side dishes, and desserts. The class seeks to improve diabetes

280

Dietary Changes for Persons with Diabetes  

E-print Network

D. Dietary Changes for Persons with Diabetes #12;Reference Guide HANDOUT Working with Persons Who Have Diabetes Follow these guidelines to work with consumers who request nutrition information on preventing or treating diabetes. Without Written Prescriptions If a client with diabetes seeks assistance

281

February 2014AZ1617 What is diabetes?  

E-print Network

February 2014AZ1617 What is diabetes? Diabetes is a disease that your blood glucose, also called get into the cells of your body for energy. People with diabetes don't make enough insulin or the body cells do not respond to insulin, causing glucose to build up in the blood. (See Figure: Diabetes

Sanderson, Mike

282

The genetic predisposition to fibrocalculous pancreatic diabetes  

Microsoft Academic Search

SummaryFibrocalculous pancreatic diabetes (previously known as tropical pancreatic diabetes) is a rare cause of diabetes confined to countries within the tropical belt. The aetiology of fibrocalculous pancreatic diabetes is thought to be environmental although the agent(s) is unknown. We have investigated a possible genetic basis of this disease by looking for restriction fragment length polymorphisms of genes implicated in the

P. K. Kambo; G. A. Hitman; V. Mohan; A. Ramachandran; C. Snehalatha; S. Suresh; K. Metcalfe; B. K. Ryait; M. Viswanathan

1989-01-01

283

The metabolic syndrome, diabetes and lung dysfunction  

Microsoft Academic Search

Sleep-disordered breathing and sleep apnoea are conditions frequently associated with comorbidity, including obesity, diabetes, hypertension, insulin resistance (metabolic syndrome) and cardiovascular disease. The diabetic state (type 1 and type 2 diabetes) may be associated to diminished lung function and, in particular, decreased vital capacity, and the association between chronic obstructive pulmonary disease (COPD) and type 2 diabetes may be due

A. Tiengo; G. P. Fadini; A. Avogaro

2008-01-01

284

Evolutionary interactions between diabetes and development  

Microsoft Academic Search

Because of the complications of diabetes affecting the mothers and their fetus\\/newborns are less known, this review examined the epidemiologic and mechanistic issues involved in the developmental programming of diabetic mothers. This overview showed that sperm, egg, zygote or blastocyst derived from diabetic parents may develop into offspring with high risk of any type of diabetes, even if placed in

R. G. Ahmed

2011-01-01

285

Modeling Type 1 Diabetes in NOD Mice  

E-print Network

Modeling Type 1 Diabetes in NOD Mice Joseph M. Mahaffy Nonlinear Dynamical Systems Group-Keshet Diabetes Oct 2006 ­ p. 2/3 #12;Outline · Biology - Diabetes and Immune Response · Mathematical Model · Bifurcation Analysis · Simulations · Discussion and Conclusions Diabetes Oct 2006 ­ p. 3/3 #12;Glucose

Mahaffy, Joseph M.

286

Diabetes monitoring system in the Netherlands  

Microsoft Academic Search

Under the aegis of the European Regional Offices of the World Health Organization (WHO) and the International Diabetes Federation (IDF) a joint action programme to contest the growing burden of diabetes has been drawn up. The St. Vincent Declaration (1989) specifies targets for diabetes care, the reduction of complications, the integration into society and the education of the diabetic individual.

D. Ruwaard; K. H. Nijdam; R. J. Heine; H. M. J. Krans; J. P. G. van Ooijen; G. E. M. G. Storms

1996-01-01

287

Imaging of diabetic retinopathy and diabetic macular edema.  

PubMed

Imaging of the retinal complications of diabetes mellitus is rapidly changing from the emergence of new technology such as optical coherence tomography. In particular, the characterization of diabetic macular edema is much easier for the clinician and there are new, more sensitive clinical research end points. However, our understanding of structure-functional relationships remains suboptimal and the classification of macular edema by optical coherence tomography continues to evolve. The classification of diabetic retinopathy severity continues to rely upon fundus photography, although the transition from film to digital photography presents both challenges and advantages. PMID:21607565

Danis, Ronald P; Hubbard, Larry D

2011-08-01

288

Gene therapy in diabetes  

PubMed Central

Type 1 diabetes (T1D) is a chronic autoimmune disease, whereby auto-reactive cytotoxic T cells target and destroy insulin-secreting ?-cells in pancreatic islets leading to insulin deficiency and subsequent hyperglycemia. These individuals require multiple daily insulin injections every day of their life without which they will develop life-threatening diabetic ketoacidosis (DKA) and die. Gene therapy by viral vector and non-viral transduction may be useful techniques to treat T1D as it can be applied from many different angles; such as the suppression of autoreactive T cells to prevent islet destruction (prophylactic) or the replacement of the insulin gene (post-disease). The need for a better method for providing euglycemia arose from insufficient numbers of cadaver islets for transplantation and the immunosuppression required post-transplant. Ectopic expression of insulin or islet modification have been examined, but not perfected. This review examines the various gene transfer methods, gene therapy techniques used to date and promising novel techniques for the maintenance of euglycemia in the treatment of T1D. PMID:21487475

Wong, Mary S; Hawthorne, Wayne J

2010-01-01

289

Metabolic Dysfunction in Diabetic Cardiomyopathy  

PubMed Central

Diabetic cardiomyopathy (DCM) is defined as cardiac disease independent of vascular complications during diabetes. The number of new cases of DCM is rising at epidemic rates in proportion to newly diagnosed cases of diabetes mellitus (DM) throughout the world. DCM is a heart failure syndrome found in diabetic patients that is characterized by left ventricular hypertrophy and reduced diastolic function, with or without concurrent systolic dysfunction, occurring in the absence of hypertension and coronary artery disease. DCM and other diabetic complications are caused in part by elevations in blood glucose and lipids, characteristic of DM. Although there are pathological consequences to hyperglycemia and hyperlipidemia, the combination of the two metabolic abnormalities potentiates the severity of diabetic complications. A natural competition exists between glucose and fatty acid metabolism in the heart that is regulated by allosteric and feedback control and transcriptional modulation of key limiting enzymes. Inhibition of these glycolytic enzymes not only controls flux of substrate through the glycolytic pathway, but also leads to the diversion of glycolytic intermediate substrate through pathological pathways, which mediate the onset of diabetic complications. The present review describes the limiting steps involved in the development of these pathological pathways and the factors involved in the regulation of these limiting steps. Additionally, therapeutic options with demonstrated or postulated effects on DCM are described. PMID:23443849

Isfort, Michael; Stevens, Sarah C.W.; Schaffer, Stephen; Jong, Chian Ju; Wold, Loren E.

2013-01-01

290

Diabetes and immunity to tuberculosis.  

PubMed

The dual burden of tuberculosis (TB) and diabetes has attracted much attention in the past decade as diabetes prevalence has increased dramatically in countries already afflicted with a high burden of TB. The confluence of these two major diseases presents a serious threat to global public health; at the same time it also presents an opportunity to learn more about the key elements of human immunity to TB that may be relevant to the general population. Some effects of diabetes on innate and adaptive immunity that are potentially relevant to TB defense have been identified, but have yet to be verified in humans and are unlikely to fully explain the interaction of these two disease states. This review provides an update on the clinical and epidemiological features of TB in the diabetic population and relates them to recent advances in understanding the mechanistic basis of TB susceptibility and other complications of diabetes. Issues that merit further investigation - such as geographic host and pathogen differences in the diabetes/TB interaction, the role of hyperglycemia-induced epigenetic reprogramming in immune dysfunction, and the impact of diabetes on lung injury and fibrosis caused by TB - are highlighted in this review. PMID:24448841

Martinez, Nuria; Kornfeld, Hardy

2014-03-01

291

Diabetes in young: Beyond type 1  

PubMed Central

Although majority of diabetes in children is type1 diabetes, childhood type2 diabetes prevalence is rapidly increasing due to changing lifestyle. Most patients can be definitely grouped into either of the two but some present diagnostic difficulty due to overlapping and non specific clinical features and laboratory findings. MODY and several other diseases affecting the pancreas also result in childhood diabetes. Treatment of diabetes in children presents unique challenges and primary prevention is of prime importance. PMID:23565393

Virmani, Anju; Kulkarni, Abhishek

2012-01-01

292

Diabetic education, special consideration of oriental patients  

Microsoft Academic Search

The important of patient education program in the management of diabetes has been widely recognized. We studied to find out\\u000a in general what the patients and their parents know about diabetes and their self-care by using a questionnaire. Then, the\\u000a diabetic education was given by one-to-one basis to every patient. Thirty four insulin-dependent diabetes mellitus attended\\u000a the diabetic the clinic

Chanika Tuchinda; Nirun Vanaprapa; Suthida Nirapik; Ranoo Wongarn; Sathit Vannasaeng

1989-01-01

293

Diabetes Education in Tribal Schools  

NSDL National Science Digital Library

American Indian/Alaska Native (AI/AN) populations are in the midst of a Type 2 diabetes epidemic. To address this crisis, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) began funding a national initiative titled "Diabetes Education in Tribal Schools (DETS) K-12 Curriculum Project." The lesson plans are structured in the 5E learning cycle and instructional model--Engage, Explore, Explain, Elaborate, and Evaluate because it supports a constructivist teaching strategy and is based on how student learning occurs.

Carolee Dodge Francis

2006-03-01

294

Surgical Management of Diabetic Retinopathy  

PubMed Central

Surgery for late complications of proliferative diabetic retinopathy remains the cornerstone of management even in patients who have received optimal laser photocoagulation and medical therapy. With improvisation in the surgical techniques and development of micro-incision surgical techniques for vitrectomy, the indications for surgical intervention are expanding to include diabetic macular edema with a greater number of patients undergoing early intervention. This review describes the current indications, surgical techniques, adjunctive anti-vascular endothelial growth factor therapy, surgical outcomes, and postoperative complications of pars plana vitrectomy for proliferative diabetic retinopathy and macular edema. PMID:24339677

Gupta, Vishali; Arevalo, J. Fernando

2013-01-01

295

Salivary alterations in diabetes mellitus.  

PubMed

Separately collected parotid and submaxillary salivary samples from 20 diabetic and 20 matched control subjects were analyzed for flow rate, electrolyte content and immunoglobulin (IgA, IgG and IgM) levels. Flow rates did not vary significantly between the two groups of subjects; calcium ion content, however, was higher in the diabetic subjects for both salivary glands. The presence of salivary IgI in 6 of 10 patients was also a significant finding. Any attempt to draw a conclusion between the severity of periodontal disease and Diabetes Mellitus from the above findings is still speculative but does indicate further areas of research. PMID:1057651

Marder, M Z; Abelson, D C; Mandel, I D

1975-09-01

296

Prevent Diabetes Problems: Keep Your Diabetes under Control  

MedlinePLUS

... need to take diabetes medicines? Print Section (PDF, 247 KB) * If you cannot reach your target blood ... Foot doctor [ Top ] Pronunciation Guide Print Section (PDF, 247 KB) * A1C (AY-WUHN-SEE) aerobic (air-OH- ...

297

Knowledge of Diabetic Complications in a Diabetic Population  

Microsoft Academic Search

This cross-sectional, questionnaire based descriptive study was carried out to evaluate the individual knowledge of diabetic complications in the diabetic patients and also to find the association of knowledge towards educational status and other socio-demographic profiles. A total 184 patients were included in this study. In this study, we found 91 subjects (48.9%) knew that heart disease was the most

Mirza Azizul Hoque; SIRAJUL ISLAM; ABDUL MALEQUE KHAN; HAM NAZMUL

2009-01-01

298

Entrevista con Jos Triana  

E-print Network

cenagoso. T has visto a esos equilibristas que atraviesan de un lado a otro en un circo, en una cuerda floja? Y t los ves que van pasando. . . . Pues eso yo creo que es una de las definiciones que podra plantearme o replantearme con la escritura... es su teora del distanciamiento . . . Eso me interesa mucho, y sobre todo distanciamiento en el sentido de la representacin. La obra de Ramn del Valle-lncln es totalmente distinta de la obra de Bertolt Brecht, y sin embargo tienen un punto...

Vasserot, Christilla

1995-10-01

299

Diabetes mellitus: Knowledge, attitude, practice and their relation to diabetes control in female diabetics.  

PubMed

In a clinic-based study, the extent to which diabetes knowledge, attitude and compliance related to glycemic control was explored. Three hundred Saudi diabetic women aged 20 years and above were randomly selected from the register of the Diabetics and Endocrine Centre in Dammam, in the Eastern Province of Saudi Arabia and personally interviewed using a pre-structured questionnaire. As an index of glycemic control, the glycated hemoglobin was assayed using a microcolumn technique. The main findings were: generally low score levels of knowledge, attitude and compliance. THe mean glycated hemoglobin was significantly higher in type I (IDDM) (10.2 +/- 2.2%) than in type 2 (NIDDM) diabetic respondents (9.1 +/- 2.0%), P = 0.001. Evidence from this study suggests there is a need for sustained active patient education, support and evaluation, in order to increase patient involvement and self-reliance in the management of their diabetes. It is recommended that diabetes care be principally the responsibility of appropriately trained and culturally compatible members of the primary health care team working in partnership with other secondary care services. Medical audit of diabetes at the primary health care level would improve clinical performance in this field. PMID:17589175

Binhemd, T A

1992-05-01

300

Protein O-GlcNAcylation in diabetes and diabetic complications  

PubMed Central

The post-translational modification of serine and threonine residues of proteins by O-linked ?-N-acetylglucosamine (O-GlcNAc) is highly ubiquitous, dynamic and inducible. Protein O-GlcNAcylation serves as a key regulator of critical biological processes including transcription, translation, proteasomal degradation, signal transduction and apoptosis. Increased O-GlcNAcylation is directly linked to insulin resistance and to hyperglycemia-induced glucose toxicity, two hallmarks of diabetes and diabetic complications. In this review, we briefly summarize what is known about protein O-GlcNAcylation and nutrient metabolism, as well as discuss the commonly used tools to probe changes of O-GlcNAcylation in cultured cells and in animal models. We then focus on some key proteins modified by O-GlcNAc, which play crucial roles in the etiology and progression of diabetes and diabetic complications. Proteomic approaches are also highlighted to provide a system view of protein O-GlcNAcylation. Finally, we discuss how aberrant O-GlcNAcylation on certain proteins may be exploited to develop methods for the early diagnosis of pre-diabetes and/or diabetes. PMID:23992419

Ma, Junfeng; Hart, Gerald W

2014-01-01

301

Carbohydrates and Diabetes (For Parents)  

MedlinePLUS

... many kids with diabetes take to stay healthy. Carbohydrates and Blood Sugar The two main forms of ... and the carbs in food. Back Continue Balancing Carbohydrates In addition to serving a balanced diet of ...

302

Diabetes in Children and Teens  

MedlinePLUS

... well. To lower the risk of type 2 diabetes in children Have them maintain a healthy weight Be sure they are physically active Have them eat smaller portions of healthy foods Limit time with the TV, computer, and video ...

303

Diabetes and Hepatitis B Vaccination  

MedlinePLUS

... for hepatitis B if they share blood glucose meters, fingerstick devices or other diabetes-care equipment such ... to have occurred from: Use of blood glucose meter for more than one resident without cleaning and ...

304

Peptides and methods against diabetes  

DOEpatents

This invention relates to methods of preventing or reducing the severity of diabetes. In one embodiment, the method involves administering to the individual a peptide having substantially the sequence of a on-conserved region sequence of a T cell receptor present on the surface of T cells mediating diabetes or a fragment thereof, wherein the peptide or fragment is capable of causing an effect on the immune system to regulate the T cells. In particular, the T cell receptor has the V.beta. regional V.beta.6 or V.beta.14. In another embodiment, the method involves gene therapy. The invention also relates to methods of diagnosing diabetes by determining the presence of diabetes predominant T cell receptors.

Albertini, Richard J. (Underhill Center, VT); Falta, Michael T. (Hinesburg, VT)

2000-01-01

305

New treatments for diabetic retinopathy.  

PubMed

Diabetic retinopathy is the major cause of vision loss in middle-aged adults. Alteration of the blood-retinal barrier (BRB) is the hallmark of diabetic retinopathy and, subsequently, hypoxia may result in retinal neovascularization. Tight control of systemic factors such as blood glucose, blood pressure and blood lipids is essential in the management of this disease. Vascular endothelial growth factor (VEGF) is one of the most important factors responsible for alteration of the BRB. The introduction of anti-VEGF agents has revolutionized the therapeutic strategies used in people with diabetic retinopathy, and the use of laser therapy has been modified. In the present article, we examine the clinical features and pathophysiology of diabetic retinopathy and review the current status of new treatment recommendations for this disease, and also explore some possible future therapies. PMID:25160598

Das, A; Stroud, S; Mehta, A; Rangasamy, S

2015-03-01

306

Diagnosis of Diabetes and Prediabetes  

MedlinePLUS

... of a blood glucose test. People of African, Mediterranean, or Southeast Asian descent or people with family ... in the NDIC booklet For People of African, Mediterranean, or Southeast Asian Heritage: Important Information about Diabetes ...

307

Long term complications of diabetes  

MedlinePLUS

... itching in other areas. Diabetes may make it harder to control your blood pressure and cholesterol. This ... attack, stroke, and other problems. It can become harder for blood to flow to the legs and ...

308

Poverty Makes Diabetes Care Tougher  

MedlinePLUS

... Map FAQs Contact Us Search MedlinePlus Health Topics Drugs & Supplements Videos & Cool Tools ESPAOL To use the sharing features on this page, please enable JavaScript. Poverty Makes Diabetes Care Tougher, Study Reports Too little ...

309

Cognitive Interventions for Older Diabetics.  

ERIC Educational Resources Information Center

Older diabetic adults should receive memory training to improve their compliance with medication taking. The intervention should include comprehensible medical instructions, assistance with remembering the nutritional values of food, and higher order skills for disease management. (SK)

Black, Sheila; Scogin, Forrest

1998-01-01

310

Technology Helps Manage Diabetes: FDA  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Technology Helps Manage Diabetes: FDA Insulin pumps and continuous ... Type 1 MONDAY, Dec. 8, 2014 (HealthDay News) -- Technology can ease some of the burden of managing ...

311

Vaccinations for Adults with Diabetes  

MedlinePLUS

Vaccinations for Adults with Diabetes The table below shows which vaccinations you should have to protect your health if ... sure you and your healthcare provider keep your vaccinations up to date. Vaccine Do you need it? ...

312

Gestational diabetes and nutritional recommendations  

Microsoft Academic Search

The goals of medical nutrition therapy for gestational diabetes mellitus (GDM) are to meet the maternal and fetal nutritional\\u000a needs, as well as to achieve and maintain optimal glycemic control. Nutrition requirements during pregnancy are similar for\\u000a women with and without GDM. The American Diabetes Association and the American College of Obstetrics and Gynecology recommend\\u000a nutrition therapy for GDM that

Erica P. Gunderson

2004-01-01

313

Male-female differences in diabetic retinopathy?  

PubMed

Abstract The purpose of this paper is to review male-female differences in the incidence and prevalence of diabetes and diabetic retinopathy. These differences will be established primarily through results from our present research and a review of related literature. Previously, we have demonstrated that neuroretinal dysfunction can be used to predict the location of future retinopathy up to three years before it is manifest. Our current research suggests that, for type 2 diabetes, the normal differences in neuroretinal function between nondiabetic males and females under 50 years of age are altered in patients with type 2 diabetes. Furthermore, local neuroretinal function in type 2 diabetes is more abnormal in adult males compared with adult females. The literature also suggests that there are male-female differences in the occurrence of diabetes. In adolescence, the incidence of type 1 diabetes is greater in males, whereas in type 2 diabetes, the incidence is greater in females. This excess of females in type 2 diabetes shifts to a more equal incidence between the two sexes in adults. In addition, advanced retinopathy in type 1 diabetes appears to be more common in males, and the presence and severity of diabetic retinopathy at the time of diagnosis in type 2 diabetes appears to be more associated with male sex. Although the reasons for male-female differences identified in this review are unknown, sex appears to be a significant factor in certain aspects of diabetes incidence and diabetic retinopathy. PMID:25545999

Ozawa, Glen Y; Bearse, Marcus A; Adams, Anthony J

2015-02-01

314

Side Effects of HIV Medicines: HIV and Diabetes  

MedlinePLUS

... needed to control type 2 diabetes. What is diabetes? Diabetes is a disease in which levels of ... controlled with diet, exercise, and medicines. How does diabetes develop? Glucose is carried in the blood to ...

315

Diabetes Mellitus Type 1: Overview (Beyond the Basics)  

MedlinePLUS

... during treatment of diabetes mellitus Moderately increased albuminuria (microalbuminuria) in type 1 diabetes mellitus Nutritional considerations in ... during treatment of diabetes mellitus Moderately increased albuminuria (microalbuminuria) in type 1 diabetes mellitus Nutritional considerations in ...

316

What Are the Signs and Symptoms of Diabetic Heart Disease?  

MedlinePLUS

... Twitter. What Are the Signs and Symptoms of Diabetic Heart Disease? Some people who have diabetic heart ... your doctor about your risk of heart failure. Diabetic Cardiomyopathy Diabetic cardiomyopathy may not cause symptoms in ...

317

Living with Diabetes: Finding the Support You Need Video  

MedlinePLUS

... Living with Diabetes: Finding the Support You Need Video If you've been diagnosed with diabetes, you ... Living with Diabetes: Finding the Support You Need Video (MP4) Keywords: self-management , behavior change , National Diabetes ...

318

Tasty Recipes for People with Diabetes and Their Families  

MedlinePLUS

... Officer, National Diabetes Education Program, Division of Diabetes Translation, Centers for Disease Control and Prevention Betsy Rodrguez, ... Advisor, National Diabetes Education Program, Division of Diabetes Translation, Centers for Disease Control and Prevention Andrea Zaldivar, ...

319

Genetics of Type 2 Diabetes  

PubMed Central

Purpose of review To provide an overview of the genetics of type 2 diabetes in the context of recent progress in the understanding of the genetic architecture of the disease and its applicability to the pathogenesis of the disease as well as efforts to individualize therapy in type 2 diabetes. Efforts are underway to understand how these loci alter measurable physiologic processes in nondiabetic humans. However, it is important to understand the potential pitfalls in such studies and the limitations underlying measurement of insulin secretion and action using qualitative methodologies. Recent findings The availability of large population-based cohorts and the ease with which large numbers of common genetic variants can be genotyped has enabled the discovery of multiple loci and pathways associated with type 2 diabetes. Recent efforts examining quantitative traits such as fasting glucose concentrations have led to the discovery of other genes likely to be important in the development of diabetes. Summary The past 4 years have witnessed a significant increase in our understanding of genetic predisposition to type 2 diabetes. Hopefully more progress will be made in applying this knowledge to the pathophysiology of type 2 diabetes in the coming years. PMID:20473152

Smushkin, Galina; Vella, Adrian

2010-01-01

320

Diabetes: Models, Signals and control  

NASA Astrophysics Data System (ADS)

Diabetes and its complications impose significant economic consequences on individuals, families, health systems, and countries. The control of diabetes is an interdisciplinary endeavor, which includes significant components of modeling, signal processing and control. Models: first, I will discuss the minimal (coarse) models which describe the key components of the system functionality and are capable of measuring crucial processes of glucose metabolism and insulin control in health and diabetes; then, the maximal (fine-grain) models which include comprehensively all available knowledge about system functionality and are capable to simulate the glucose-insulin system in diabetes, thus making it possible to create simulation scenarios whereby cost effective experiments can be conducted in silico to assess the efficacy of various treatment strategies - in particular I will focus on the first in silico simulation model accepted by FDA as a substitute to animal trials in the quest for optimal diabetes control. Signals: I will review metabolic monitoring, with a particular emphasis on the new continuous glucose sensors, on the crucial role of models to enhance the interpretation of their time-series signals, and on the opportunities that they present for automation of diabetes control. Control: I will review control strategies that have been successfully employed in vivo or in silico, presenting a promise for the development of a future artificial pancreas and, in particular, I will discuss a modular architecture for building closed-loop control systems, including insulin delivery and patient safety supervision layers.

Cobelli, C.

2010-07-01

321

Smoking and Type 2 Diabetes Mellitus  

PubMed Central

Cigarette smoking is a well-known risk factor in many diseases, including various kinds of cancer and cardiovascular disease. Many studies have also reported the unfavorable effects of smoking for diabetes mellitus. Smoking increases the risk of developing diabetes, and aggravates the micro- and macro-vascular complications of diabetes mellitus. Smoking is associated with insulin resistance, inflammation and dyslipidemia, but the exact mechanisms through which smoking influences diabetes mellitus are not clear. However, smoking cessation is one of the important targets for diabetes control and the prevention diabetic complications. PMID:23275932

2012-01-01

322

The diabetic foot: a review.  

PubMed

Diabetic foot ulceration (DFU) is among the most frequent complications of diabetes. Neuropathy and ischaemia are the initiating factors and infection is mostly a consequence. We have shown in this review that any DFU should be considered to have vascular impairment. DFU will generally heal if the toe pressure is >55 mmHg and a transcutaneous oxygen pressure (TcPO2) <30 mmHg has been considered to predict that a diabetic ulcer may not heal. The decision to intervene is complex and made according to the symptoms and clinical ?ndings. If both an endovascular and a bypass procedure are possible with an equal outcome to be expected, endovascular treatments should be preferred. Primary and secondary mid-term patency rates are better after bypass, but there is no difference in limb salvage. Bedridden patients with poor life expectancy and a non-revascularisable leg are indications for performing a major amputation. A deep infection is the immediate cause of amputation in 25% to 50% of diabetic patients. Patients with uncontrolled abscess, bone or joint involvement, gangrene, or necrotising fasciitis have a "foot-at risk" and need prompt surgical intervention with debridement and revascularisation. As demonstrated in this review, foot ulcer in diabetic is associated with high mortality and morbidity. Early referral, non-invasive vascular testing, imaging and intervention are crucial to improve DFU healing and to prevent amputation. Diabetics are eight to twenty-four times more likely than non-diabetics to have a lower limb amputation and it has been suggested that a large part of those amputations could be avoided by an early diagnosis and a multidisciplinary approach. PMID:24126512

Ricco, J B; Thanh Phong, L; Schneider, F; Illuminati, G; Belmonte, R; Valagier, A; Rgnault De La Mothe, G

2013-12-01

323

Amadori albumin in diabetic nephropathy.  

PubMed

Nonenzymatic glycation of macromolecules in diabetes mellitus (DM) is accelerated due to persistent hyperglycemia. Reducing sugar such as glucose reacts non enzymatically with free -amino groups of proteins through series of reactions forming Schiff bases. These bases are converted into Amadori product and further into AGEs. Non enzymatic glycation has the potential to alter the biological, structural and functional properties of macromolecules both in vitro and in vivo. Studies have suggested that amadori as well as AGEs are involved in the micro-macro vascular complications in DM, but most studies have focused on the role of AGEs in vascular complications of diabetes. Recently putative AGE-induced patho-physiology has shifted attention from the possible role of amadori-modified proteins, the predominant form of the glycated proteins in the development of the diabetic complications. Human serum albumin (HSA), the most abundant protein in circulation contains 59 lysine and 23 arginine residues that could, in theory be involved in glycation. Albumin has dual nature, first as a marker of intermediate glycation and second as a causative agent of the damage of tissues. Among the blood proteins, hemoglobin and albumin are the most common proteins that are glycated. HSA with a shorter half life than RBC, appears to be an alternative marker of glycemic control as it can indicate blood glucose status over a short period (2-3 weeks) and being unaffected by RBCs life span and variant haemoglobin, anemia etc which however, affect HbA1c. On the other hand, Amadori albumin may accumulate in the body tissues of the diabetic patients and participate in secondary complications. Amadori-albumin has potential role in diabetic glomerulosclerosis due to long term hyperglycaemia and plays an important role in the pathogenesis of diabetic nephropathy. This review is an approach to compile both the nature of glycated albumin as a damaging agent of tissues and as an intermediate diagnostic marker and its potential role in diabetic nephropathy. PMID:25593824

Neelofar, Km; Ahmad, Jamal

2015-01-01

324

Amadori albumin in diabetic nephropathy  

PubMed Central

Nonenzymatic glycation of macromolecules in diabetes mellitus (DM) is accelerated due to persistent hyperglycemia. Reducing sugar such as glucose reacts non enzymatically with free -amino groups of proteins through series of reactions forming Schiff bases. These bases are converted into Amadori product and further into AGEs. Non enzymatic glycation has the potential to alter the biological, structural and functional properties of macromolecules both in vitro and in vivo. Studies have suggested that amadori as well as AGEs are involved in the micro-macro vascular complications in DM, but most studies have focused on the role of AGEs in vascular complications of diabetes. Recently putative AGE-induced patho-physiology has shifted attention from the possible role of amadori-modified proteins, the predominant form of the glycated proteins in the development of the diabetic complications. Human serum albumin (HSA), the most abundant protein in circulation contains 59 lysine and 23 arginine residues that could, in theory be involved in glycation. Albumin has dual nature, first as a marker of intermediate glycation and second as a causative agent of the damage of tissues. Among the blood proteins, hemoglobin and albumin are the most common proteins that are glycated. HSA with a shorter half life than RBC, appears to be an alternative marker of glycemic control as it can indicate blood glucose status over a short period (2-3 weeks) and being unaffected by RBCs life span and variant haemoglobin, anemia etc which however, affect HbA1c. On the other hand, Amadori albumin may accumulate in the body tissues of the diabetic patients and participate in secondary complications. Amadori-albumin has potential role in diabetic glomerulosclerosis due to long term hyperglycaemia and plays an important role in the pathogenesis of diabetic nephropathy. This review is an approach to compile both the nature of glycated albumin as a damaging agent of tissues and as an intermediate diagnostic marker and its potential role in diabetic nephropathy. PMID:25593824

Neelofar, Km.; Ahmad, Jamal

2015-01-01

325

DIABETES/METABOLISM RESEARCH AND REVIEWS REVIEW ARTICLE Diabetes Metab Res Rev 2008; 24: 604610.  

E-print Network

DIABETES/METABOLISM RESEARCH AND REVIEWS REVIEW ARTICLE Diabetes Metab Res Rev 2008; 24: 604 Nanomedicine and its potential in diabetes research and practice John C. Pickup1* Zheng-Liang Zhi1 Faaizah Khan­100 nm. Although the science is still in its infancy, it has major potential applications in diabetes

Strathclyde, University of

326

New safety concerns over diabetes drugs Two drugs commonly prescribed to treat diabetes  

E-print Network

New safety concerns over diabetes drugs Two drugs commonly prescribed to treat diabetes double of Type II Diabetes. Prescriptions for the drugs, known as thiazolidinediones, have doubled over the last. The results are published in the August edition of the journal Diabetes Care. Congregation 2007 page 5­9 Race

Feigon, Brooke

327

DIABETES/METABOLISM RESEARCH AND REVIEWS RESEARCH ARTICLE Diabetes Metab Res Rev 2003; 19: 288298.  

E-print Network

DIABETES/METABOLISM RESEARCH AND REVIEWS RESEARCH ARTICLE Diabetes Metab Res Rev 2003; 19: 288 Nerve collagens from diabetic and nondiabetic Sprague­Dawley and biobreeding rats: an atomic force Accepted: 14 January 2003 Abstract Background Alterations in rat's nerve collagens due to diabetes may

Sastry, Ann Marie

328

Overview of Diabetes in Children and Adolescents. A Fact Sheet from the National Diabetes Education Program  

ERIC Educational Resources Information Center

Type 1 diabetes in U.S. children and adolescents may be increasing and many more new cases of type 2 diabetes are being reported in young people. Standards of care for managing children with diabetes issued by the American Diabetes Association in January 2005 provide more guidance than previously given. To update primary care providers and their

National Diabetes Education Program (NDEP), 2006

2006-01-01

329

DIABETES/METABOLISM RESEARCH AND REVIEWS RESEARCH ARTICLE Diabetes Metab Res Rev 2005; 21: 264270.  

E-print Network

DIABETES/METABOLISM RESEARCH AND REVIEWS RESEARCH ARTICLE Diabetes Metab Res Rev 2005; 21: 264 Design and development of a scale measuring fear of complications in type 1 diabetes Emily P. Taylor1 John R. Crawford2 Ann E. Gold3* 1 Department of Diabetes, Grampian University Hospitals Trust, Aberdeen

Crawford, John R.

330

Diabetes Metab . Author manuscript Epidemiology of diabetic retinopathy: expected vs reported prevalence of  

E-print Network

Diabetes Metab . Author manuscript Page /1 10 Epidemiology of diabetic retinopathy: expected vs due to retinopathy are amongst the most feared complications in diabetic patients. As the number of diabetic patients is predicted to increase, a corresponding increase in the number of patients affected

Boyer, Edmond

331

Diabetes Care . Author manuscript Antidepressant use before and after the diagnosis of type 2 diabetes: a  

E-print Network

Diabetes Care . Author manuscript Page /1 9 Antidepressant use before and after the diagnosis of type 2 diabetes: a longitudinal modeling study Mika Kivim kiä 1 2 3 * , Adam G. Tab ká 4 , Debbie A University of Helsinki , FI Steno Diabetes Center10 Steno Diabetes Center , Gentofte,DK * Correspondence

Paris-Sud XI, Université de

332

SMART DIABETIC SOCKS: Embedded Device for Diabetic Foot Prevention Antoine Perrier1,2,3  

E-print Network

SMART DIABETIC SOCKS: Embedded Device for Diabetic Foot Prevention Antoine Perrier1,2,3 , Nicolas (repetitive high stress, ill-fitting footwear, or an object inside the shoe) associated to diabetes of the Smart Diabetic Socks that has been developed in the context of the French ANR TecSan project

Boyer, Edmond

333

Anti-diabetic effects of rice hull smoke extract in alloxan-induced diabetic mice  

Technology Transfer Automated Retrieval System (TEKTRAN)

We investigated the protective effect of a liquid rice hull smoke extract (RHSE) against diabetes in alloxan-induced diabetic mice. Anti-diabetic effects of RHSE were evaluated in both the rat insulinoma-1 cell line (INS-1) and diabetic ICR mice induced by inraperitoneal (ip) injection of alloxan. ...

334

Evaluation of the Impact of the Kuwait Diabetes Care Program on the Quality of Diabetes Care  

Microsoft Academic Search

Objectives: To evaluate the impact of the Kuwait Diabetes Care Program on the quality of care provided for diabetic patients in the Primary Health Care setting. Materials and Methods: The Kuwait Diabetes Care Program developed, published and disseminated clinical practice guidelines, conducted training courses, standards for diabetes care, and introduced a monitoring and evaluation system. Four audits (September 1999, October

Afaf Al-Adsani; Jamila Al-Faraj; Fatma Al-Sultan; Mohamed El-Feky; Nouria Al-Mezel; Wafik Saba; Sharifa Aljassar

2008-01-01

335

Materials for Diabetes Therapeutics  

PubMed Central

This review is focused on the materials and methods used to fabricate closed-loop systems for type 1 diabetes therapy. Herein, we give a brief overview of current methods used for patient care and discuss two types of possible treatments and the materials used for these therapies(i) artificial pancreases, comprised of insulin producing cells embedded in a polymeric biomaterial, and (ii) totally synthetic pancreases formulated by integrating continuous glucose monitors with controlled insulin release through degradable polymers and glucose-responsive polymer systems. Both the artificial and the completely synthetic pancreas have two major design requirements: the device must be both biocompatible and be permeable to small molecules and proteins, such as insulin. Several polymers and fabrication methods of artificial pancreases are discussed: microencapsulation, conformal coatings, and planar sheets. We also review the two components of a completely synthetic pancreas. Several types of glucose sensing systems (including materials used for electrochemical, optical, and chemical sensing platforms) are discussed, in addition to various polymer-based release systems (including ethylene-vinyl acetate, polyanhydrides, and phenylboronic acid containing hydrogels). PMID:23184741

Bratlie, Kaitlin M.; York, Roger L.; Invernale, Michael A.; Langer, Robert

2013-01-01

336

Gestational Diabetes: A Guide for Pregnant Women  

MedlinePLUS

... Sumaria de los Consumidores Aug. 25, 2010 Gestational Diabetes Related Products Future Research Needs: Prioritizing Research Needs ... Women" /> Consumer Summary Aug. 5, 2009 Gestational Diabetes: A Guide for Pregnant Women Formats Consumer Guide ( ...

337

Women and Diabetes: Frequently Asked Questions  

MedlinePLUS

... magazine: women, In this section Living With Diabetes Treatment and Care Women Coronary Heart Disease Sexual Health Women and Diabetes: Frequently Asked Questions Eating Disorders Polycystic Ovarian Syndrome (PCOS) donate en -- Last Chance ...

338

For Men, Ignoring Diabetes Can Be Deadly  

MedlinePLUS

... page please turn Javascript on. Feature: Diabetes For Men, Ignoring Diabetes Can Be Deadly Past Issues / Fall ... that when it comes to their own health, men have fewer checkups with a regular healthcare provider ...

339

Diabetes - Multiple Languages: MedlinePlus  

MedlinePLUS

... Oromo) Portuguese (portugus) Russian (???????) Samoan (Gagana Samoa) Somali (af Soomaali) Spanish (espaol) Tagalog (Tagalog) Thai (???????) ... PDF National Diabetes Education Program Return to top Somali (af Soomaali) Diabetes Kaadi sonkorow - af Soomaali (Somali) ...

340

Managing Complications of Diabetes in Later Life  

MedlinePLUS

... Download PDF Managing Complications of Diabetes in Later Life Download Join our e-newsletter! Resources Managing Complications of Diabetes in Later Life Tools and Tips Printer-friendly PDF Click here ...

341

DMA : a diabetes disease management system  

E-print Network

There is a clear and present need to improve the quality of diabetes care. Information technology can be used as a means to that end. In this article, we discuss the design and implementation of a web-based diabetes ...

Dubey, Anil Kumar, 1967-

2003-01-01

342

Diabetic Foot - Multiple Languages: MedlinePlus  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Diabetic Foot - Multiple Languages Amharic (amarunya) Arabic (???????) Chinese - Simplified ( ... ??????? Multimedia Patient Education Institute Chinese - Simplified (????) Diabetic Foot Care English ??????? - ???? (Chinese - Simplified) PDF Chinese ...

343

How Can Diabetic Heart Disease Be Prevented?  

MedlinePLUS

... page from the NHLBI on Twitter. How Can Diabetic Heart Disease Be Prevented? Taking action to control ... lifestyle changes and medicines, go to "How Is Diabetic Heart Disease Treated?" Rate This Content: Next >> September ...

344

Diabetes May Affect Kids' Brain Growth  

MedlinePLUS

... please enable JavaScript. Diabetes May Affect Kids' Brain Growth, Study Reports But there was no effect on ... HealthDay News) -- High blood sugar may slow brain growth in young children with type 1 diabetes, a ...

345

Women at High Risk for Diabetes  

MedlinePLUS

... problem that can affect a womans hormones, menstrual cycle, and ability to have children. National Center for ... D, Crume T. Maternal environment and the transgenerational cycle of obesity and diabetes. Diabetes Care, 2011;60: ...

346

Diabetes-related clinical issues represented by the "Faces of Diabetes".  

PubMed

Members of the "osteopathic medical family" who themselves are patients with diabetes related their medical histories at the American College of Osteopathic Family Physicians symposium, "The Faces of Diabetes." The program was conducted Monday, October 7, 2002, in Las Vegas during the 107th Annual American Osteopathic Association Convention and Scientific Seminar. This article briefly discusses issues in the management of diabetes illustrated by the individual histories. Topics represented by "the faces of diabetes" include diabetes and comorbidities, hypoglycemia in diabetes mellitus, abnormalities associated with insulin-induced hypoglycemia, and diabetes in pregnancy. PMID:12962205

Freeman, Jeffrey S

2003-08-01

347

Functional food and diabetes: a natural way in diabetes prevention?  

PubMed

Diabetes shows a wide range of variation in prevalence around the world and it is expected to affect 300 million by the year 2025. In a prevention framework where banning policies and educational strategies lead the interventions, functional foods (FFs) with their specific health effects could, in the future, indicate a new mode of thinking about the relationships between food and health in everyday life. Functional ingredients, such as stevioside, cinnamon, bitter melon, garlic and onion, ginseng, Gymnema sylvestre and fenugreek, have been addressed for their specific actions towards different reactions involved in diabetes development. New strategies involving the use of FF should be validated through large-scale population trials, considering validated surrogate end points to evaluate the effect of FF in prevention of chronic diseases such as type 2 diabetes mellitus. PMID:22107597

Ballali, Simonetta; Lanciai, Federico

2012-03-01

348

Oxidative Stress and Diabetic Retinopathy  

PubMed Central

Oxygen metabolism is essential for sustaining aerobic life, and normal cellular homeostasis works on a fine balance between the formation and elimination of reactive oxygen species (ROS). Oxidative stress, a cytopathic consequence of excessive production of ROS and the suppression of ROS removal by antioxidant defense system, is implicated in the development of many diseases, including Alzheimer's disease, and diabetes and its complications. Retinopathy, a debilitating microvascular complication of diabetes, is the leading cause of acquired blindness in developed countries. Many diabetes-induced metabolic abnormalities are implicated in its development, and appear to be influenced by elevated oxidative stress; however the exact mechanism of its development remains elusive. Increased superoxide concentration is considered as a causal link between elevated glucose and the other metabolic abnormalities important in the pathogenesis of diabetic complications. Animal studies have shown that antioxidants have beneficial effects on the development of retinopathy, but the results from very limited clinical trials are somewhat ambiguous. Although antioxidants are being used for other chronic diseases, controlled clinical trials are warranted to investigate potential beneficial effects of antioxidants in the development of retinopathy in diabetic patients. PMID:17641741

Kowluru, Renu A.; Chan, Pooi-See

2007-01-01

349

Optimal treatment of diabetic retinopathy  

PubMed Central

Diabetic retinopathy (DRP) is a common complication caused by multiple biochemical abnormalities of the underlying metabolic disease. While the incidence of DRP appears to decline due to evidence-based changes in diabetes management, the predicted increase in patients affected in particular by type 2 diabetes may outweigh the positive trend. The diagnosis is based on the alterations of the vessels, usually indicating abnormalities of the bloodretinal barrier and increased vasoregression, but the neuroglial elements appear equally vulnerable to the diabetic condition. Control of blood glucose, blood pressure and timely identification of coincident nephropathy are important to prevent progression to vision-threatening stages. Guidelines give specific indications for laser photocoagulation, in particular when euglycemia is no longer effective in preventing progression to advanced stages. Intravitreal administration of antibodies directed against the single best characterized propagator of clinically significant macular edema, vascular endothelial growth factor (VEGF), has become popular despite uncertainty about the patient subgroups which benefit best and the optimum administration schedule. Multifactorial intervention beyond glycemic control includes antihypertensive, lipid-lowering and antiaggregatory and is effective in type 2 diabetic patients with high-risk profiles, in particular coincident nephropathy. PMID:23626903

2013-01-01

350

Gut microbiota, probiotics and diabetes  

PubMed Central

Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic ? cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. Research in animal models and humans has hypothesized whether the administration of probiotics may improve the prognosis of diabetes through modulation of gut microbiota. We have shown in this review that a large body of evidence suggests probiotics reduce the inflammatory response and oxidative stress, as well as increase the expression of adhesion proteins within the intestinal epithelium, reducing intestinal permeability. Such effects increase insulin sensitivity and reduce autoimmune response. However, further investigations are required to clarify whether the administration of probiotics can be efficiently used for the prevention and management of diabetes. PMID:24939063

2014-01-01

351

Gut microbiota, probiotics and diabetes.  

PubMed

Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic ? cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. Research in animal models and humans has hypothesized whether the administration of probiotics may improve the prognosis of diabetes through modulation of gut microbiota. We have shown in this review that a large body of evidence suggests probiotics reduce the inflammatory response and oxidative stress, as well as increase the expression of adhesion proteins within the intestinal epithelium, reducing intestinal permeability. Such effects increase insulin sensitivity and reduce autoimmune response. However, further investigations are required to clarify whether the administration of probiotics can be efficiently used for the prevention and management of diabetes. PMID:24939063

Gomes, Aline Corado; Bueno, Allain Amador; de Souza, Rvila Graziany Machado; Mota, Joo Felipe

2014-01-01

352

The management of gestational diabetes  

PubMed Central

The incidence of gestational diabetes is increasing. As gestational diabetes is associated with adverse pregnancy outcomes, and has long-term implications for both mother and child, it is important that it is recognized and appropriately managed. This review will examine the pharmacological options for the management of gestational diabetes, as well as the evidence for blood glucose monitoring, dietary and exercise therapy. The medical management of gestational diabetes is still evolving, and recent randomized controlled trials have added considerably to our knowledge in this area. As insulin therapy is effective and safe, it is considered the gold standard of pharmacotherapy for gestational diabetes, against which other treatments have been compared. The current experience is that the short acting insulin analogs lispro and aspart are safe, but there are only limited data to support the use of long acting insulin analogs. There are randomized controlled trials which have demonstrated efficacy of the oral agents glyburide and metformin. Whilst short-term data have not demonstrated adverse effects of glyburide and metformin on the fetus, and they are increasingly being used in pregnancy, there remain long-term concerns regarding their potential for harm. PMID:19436673

Cheung, N Wah

2009-01-01

353

Language barrier and its relationship to diabetes and diabetic retinopathy  

PubMed Central

Background Language barrier is an important determinant of health care access and health. We examined the associations of English proficiency with type-2 diabetes (T2DM) and diabetic retinopathy (DR) in Asian Indians living in Singapore, an urban city where English is the predominant language of communication. Methods This was a population-based, cross-sectional study. T2DM was defined as HbA1c ?6.5%, use of diabetic medication or a physician diagnosis of diabetes. Retinal photographs were graded for the severity of DR including vision-threatening DR (VTDR). Presenting visual impairment (VI) was defined as LogMAR visual acuity?>?0.30 in the better-seeing eye. English proficiency at the time of interview was assessed. Results The analyses included 2,289 (72.1%) English-speaking and 885 (27.9%) Tamil- speaking Indians. Tamil-speaking Indians had significantly higher prevalence of T2DM (46.2 vs. 34.7%, p?diabetes, higher prevalence of DR (36.0 vs. 30.6%, p?diabetic retinopathy. Social policies and health interventions that address language-related health disparities may help reduce the public health impact of T2DM in societies with heterogeneous populations. PMID:22974298

2012-01-01

354

Polymeric Gene Delivery for Diabetic Treatment  

PubMed Central

Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal. PMID:21977450

2011-01-01

355

Periodontal treatment needs of diabetic adults  

Microsoft Academic Search

Aim: The aim of this study was to investigate diabetes-related factors in relation to periodontal treatment needs. Material and Methods: A cross-sectional study was conducted among 299 dentate diabetics attending a diabetic clinic in Tehran, Iran. A self-administered questionnaire was administered during a dental appointment in order to gather information about year of birth, year of onset of diabetes, education

S Bakhshandeh; H Murtomaa; R Mofid; MM Vehkalahti; Suomalainen K. Periodontal

2007-01-01

356

La salud en personas con discapacidad intelectual en Espaa: estudio europeo POMONA-II  

PubMed Central

Introduccin Estudios internacionales demuestran que existe un patrn diferenciado de salud y una disparidad en la atencin sanitaria entre personas con discapacidad intelectual (DI) y poblacin general. Objetivo Obtener datos sobre el estado de salud de las personas con DI y compararlos con datos de poblacin general. Pacientes y mtodos Se utiliz el conjunto de indicadores de salud P15 en una muestra de 111 sujetos con DI. Los datos de salud encontrados se compararon segn el tipo de residencia de los sujetos y se utiliz la Encuesta Nacional de Salud 2006 para comparar estos datos con los de la poblacin general. Resultados La muestra con DI present 25 veces ms casos de epilepsia y el doble de obesidad. Un 20% present dolor bucal, y existi una alta presencia de problemas sensoriales, de movilidad y psicosis. Sin embargo, encontramos una baja presencia de patologas como la diabetes, la hipertensin, la osteoartritis y la osteoporosis. Tambin presentaron una menor participacin en programas de prevencin y promocin de la salud, un mayor nmero de ingresos hospitalarios y un uso menor de los servicios de urgencia. Conclusiones El patrn de salud de las personas con DI difiere del de la poblacin general, y stas realizan un uso distinto de los servicios sanitarios. Es importante el desarrollo de programas de promocin de salud y de formacin profesional especficamente diseados para la atencin de personas con DI, as como la implementacin de encuestas de salud que incluyan datos sobre esta poblacin. PMID:21948011

Martnez-Leal, Rafael; Salvador-Carulla, Luis; Gutirrez-Colosa, Menca Ruiz; Nadal, Margarida; Novell-Alsina, Ramn; Martorell, Almudena; Gonzlez-Gordn, Rodrigo G.; Mrida-Gutirrez, M. Reyes; ngel, Silvia; Milagrosa-Tejonero, Luisa; Rodrguez, Alicia; Garca-Gutirrez, Juan C.; Prez-Vicente, Amado; Garca-Ibez, Jos; Aguilera-Ins, Francisco

2011-01-01

357

Causes of albuminuria in patients with type 2 diabetes without diabetic retinopathy  

Microsoft Academic Search

Causes of albuminuria in patients with type 2 diabetes without diabetic retinopathy.BackgroundThe causes of albuminuria in patients with type 2 diabetes are heterogeneous and are scantily investigated, particularly if the patient has a lack of diabetic retinopathy. Therefore, we evaluated the structural background of albuminuria in a large consecutive group of Caucasian patients with type 2 diabetes without retinopathy.MethodsThree hundred

Per K. Christensen; Svend Larsen; Thomas Horn; Steen Olsen; Hans-Henrik Parving

2000-01-01

358

What'sforLunch? Campaign Against Diabetes  

E-print Network

What'sforLunch? n 1 n What's For Lunch at cunY? Campaign Against Diabetes City University of New and diabetes. #12;n 2 n What's for Lunch at cunY? Stacy, a psychology student at Queens College, is hungry, has just been diagnosed with pre-diabetes. She is trying hard to find food that will help her to lose

Qiu, Weigang

359

Diabetes Mellitus Glucose Prediction by Linear and  

E-print Network

Diabetes Mellitus Glucose Prediction by Linear and Bayesian Ensemble Modeling Fredrik St was diagnosed with diabetes type 1. Being an engineer with a control and systems oriented curriculum I realized of diabetes glucose metabolism, and bringing new hope of technical solutions to support the management

360

Diabetes Education Program Blood Glucose Monitoring  

E-print Network

Diabetes Education Program Blood Glucose Monitoring Self Blood Glucose Monitoring is an easy way to assess your diabetes control. This information will help you and your doctor see how your treatment plan in a very short amount of time with a simple finger prick. Your diabetes educator will help you select

Oliver, Douglas L.

361

A Diabetes Education Program for Pharmacy Students  

Microsoft Academic Search

This paper describes a novel education program for doctor of pharmacy students about diabetes, a chronic disorder of glucose metabolism affecting an estimated 16 million people in the United States. The Diabetes Program (DP) incorporates didactic learning, web-based case evaluation, and role play into a two-week comprehensive module on diabetes care. In the DP, students are placed in the role

Peggy Soule Odegard; Linda Lawless LaVigne; Allan Ellsworth

362

Health Tip: Breast-Feeding with Diabetes  

MedlinePLUS

... on this page, please enable JavaScript. Health Tip: Breast-feeding With Diabetes Potential benefits for both mom and ... Kohnle Wednesday, October 22, 2014 Related MedlinePlus Pages Breastfeeding Diabetes and Pregnancy (HealthDay News) -- Diabetic moms, after ...

363

Medication or Lifestyle for Pre-Diabetes  

MedlinePLUS

... Tools & Resources Stroke More Medication or Lifestyle for Pre-diabetes Updated:Mar 8,2014 Whats best? Medication ... but a healthy lifestyle will make a difference. Pre-diabetes Introduction About Pre-diabetes What's the Problem? ...

364

Mathematical Modeling of Diabetes Reference list  

E-print Network

Mathematical Modeling of Diabetes Reference list General 1. The world health report 2003: Today's challenges. [http://www.who.int/whr/2003/en]. Geneva, World Health Organization 2. International Diabetes Federation: IFD report 2003. [http://www.idf.org/home/index.cfm]. 3. Ratner RE: Type 2 diabetes mellitus

Gurarie, David

365

Application to the Diabetic Retinopathy Study  

E-print Network

Chapter 4 Application to the Diabetic Retinopathy Study In this chapter we apply the log hazard regression model to data collected to study the effect of laser treatment on diabetic retinopathy (see Diabetic Retinopathy Study Research Group, 1981). We give a description of this study in Section 4

Heckman, Nancy E.

366

A Communication Platform for Diabetes Surveillance  

Microsoft Academic Search

Diabetes mellitus is a common and precarious chronic disease, which affects cellular metabolism and energy production. The condition is divided into types I and II; the most common form is type II diabetes, which is an adult-onset disease. Blood glucose testing is crucial to diabetes control, and it is effective in reducing the risk of complications and improving life quality.

Yi-Ting Liao; Shih-Tsang Tang; Ting-Chun Chen; Chia-Hsin Tsao; Tsung-Chieh Lee; Yueh-Fang Huang; Shuenn-Tsong Young

2004-01-01

367

Commentary - Making a Difference in Diabetes Care  

Microsoft Academic Search

To prevent pre-diabetes or diabetes, we must place greater emphasis on weight loss and exercise in those who are overweight or obese. Equally important, we must continually exhort patients of normal weight not to put on pounds. For the former, both drug therapy and lifestyle modification have been shown to be effective in delaying the progression to diabetes, but admittedly

Richard Kahn

2006-01-01

368

Link between obesity and type 2 diabetes  

Microsoft Academic Search

The relationship between obesity and diabetes is of such interdependence that the term 'diabesity' has been coined. The passage from obesity to diabetes is made by a progressive defect in insulin secretion coupled with a progressive rise in insulin resistance. Both insulin resistance and defective insulin secretion appear very prematurely in obese patients, and both worsen similarly towards diabetes. Thus,

J. Ybarra

2005-01-01

369

Diabetes in American Indians and Alaska Natives  

MedlinePLUS

... diabetes/pubs/pdf/ndfs_2011.pdf) 9 times higher Likelihood of American Indian and Alaska Native youth aged 10-19 diagnosed type 2 diabetes compared to non-Hispanic whites (1.74 1000 vs. 0.19 per 1000; 2001). Source: SEARCH for Diabetes in Youth Study (http:// ...

370

Exercise: An Alternative Therapy for Gestational Diabetes.  

ERIC Educational Resources Information Center

Exercise is encouraged in the management of pregnant women with gestational diabetes or women with Type II diabetes who become pregnant. Although non-weight-bearing exercises may be best for sedentary women, moderate workouts appear to be safe for most women with gestational diabetes. The role of exercise, risk factors, warning signs, and examples

Artal, Raul

1996-01-01

371

Do Well, Be Well with Diabetes 2014 1 Wrap-Up Form for People with Diabetes Wrap-Up Form for People with Diabetes 2014  

E-print Network

Do Well, Be Well with Diabetes ­ 2014 1 Wrap-Up Form for People with Diabetes Wrap-Up Form for People with Diabetes ­ 2014 Please complete this form ONLY IF YOU HAVE DIABETES. Thank you. A. The month. _____ Walk or do some other similar activity at least 30 minutes on 5 days each week 3. _____ Take diabetes

372

Diabetes and Retinal Vascular Dysfunction  

PubMed Central

Diabetes predominantly affects the microvascular circulation of the retina resulting in a range of structural changes unique to this tissue. These changes ultimately lead to altered permeability, hyperproliferation of endothelial cells and edema, and abnormal vascularization of the retina with resulting loss of vision. Enhanced production of inflammatory mediators and oxidative stress are primary insults with significant contribution to the pathogenesis of diabetic retinopathy (DR). We have determined the identity of the retinal vascular cells affected by hyperglycemia, and have delineated the cell autonomous impact of high glucose on function of these cells. We discuss some of the high glucose specific changes in retinal vascular cells and their contribution to retinal vascular dysfunction. This knowledge provides novel insight into the molecular and cellular defects contributing to the development and progression of diabetic retinopathy, and will aid in the development of innovative, as well as target specific therapeutic approaches for prevention and treatment of DR.

Shin, Eui Seok; Sorenson, Christine M.; Sheibani, Nader

2014-01-01

373

Regenerative Therapies for Diabetic Microangiopathy  

PubMed Central

Hyperglycaemia occurring in diabetes is responsible for accelerated arterial remodeling and atherosclerosis, affecting the macro- and the microcirculatory system. Vessel injury is mainly related to deregulation of glucose homeostasis and insulin/insulin-precursors production, generation of advanced glycation end-products, reduction in nitric oxide synthesis, and oxidative and reductive stress. It occurs both at extracellular level with increased calcium and matrix proteins deposition and at intracellular level, with abnormalities of intracellular pathways and increased cell death. Peripheral arterial disease, coronary heart disease, and ischemic stroke are the main causes of morbidity/mortality in diabetic patients representing a major clinical and economic issue. Pharmacological therapies, administration of growth factors, and stem cellular strategies are the most effective approaches and will be discussed in depth in this comprehensive review covering the regenerative therapies of diabetic microangiopathy. PMID:22536216

Bassi, Roberto; Trevisani, Alessio; Tezza, Sara; Ben Nasr, Moufida; Gatti, Francesca; Vergani, Andrea; Farina, Antonio; Fiorina, Paolo

2012-01-01

374

Hypoglycaemia in Type 2 diabetes  

PubMed Central

The primary cause of hypoglycaemia in Type 2 diabetes is diabetes medicationin particular, those which raise insulin levels independently of blood glucose, such as sulphonylureas (SUs) and exogenous insulin. The risk of hypoglycaemia is increased in older patients, those with longer diabetes duration, lesser insulin reserve and perhaps in the drive for strict glycaemic control. Differing definitions, data collection methods, drug type/regimen and patient populations make comparing rates of hypoglycaemia difficult. It is clear that patients taking insulin have the highest rates of self-reported severe hypoglycaemia (25% in patients who have been taking insulin for > 5 years). SUs are associated with significantly lower rates of severe hypoglycaemia. However, large numbers of patients take SUs in the UK, and it is estimated that each year > 5000 patients will experience a severe event caused by their SU therapy which will require emergency intervention. Hypoglycaemia has substantial clinical impact, in terms of mortality, morbidity and quality of life. The cost implications of severe episodesboth direct hospital costs and indirect costsare considerable: it is estimated that each hospital admission for severe hypoglycaemia costs around 1000. Hypoglycaemia and fear of hypoglycaemia limit the ability of current diabetes medications to achieve and maintain optimal levels of glycaemic control. Newer therapies, which focus on the incretin axis, may carry a lower risk of hypoglycaemia. Their use, and more prudent use of older therapies with low risk of hypoglycaemia, may help patients achieve improved glucose control for longer, and reduce the risk of diabetic complications. Diabet. Med. 25, 245254 (2008) PMID:18215172

Amiel, S A; Dixon, T; Mann, R; Jameson, K

2008-01-01

375

[Cerebral complications of diabetes mellitus].  

PubMed

According to WHO data more than 180 million people suffer from diabetes mellitus worldwide and this number could double within 15 years. Normal function of the brain is dependent on continuous supply of glucose. In hypoglycemia, production of counterregulatory hormones (glucagon, epinephrine, growth hormone, and cortisol) increases, the sympathetic system becomes stimulated, and features of neuroglycopenia appear in order to save the homeostasis. Hypoglycemia is an alarming, actually life threatening condition, but the exposure to chronic hyperglycemia has a more detrimental effect on the brain than recurrent exposure to severe hypoglycemia. The active neural response to hyperglycemia induces changes in gene expression and function. The first steps against hyperosmolality are initially adaptive, but later hyperactivation of the hypothalamic magnocellular neurosecretory cells leads to their structural damage. Changes in hippocampal gene transcription are partially implicated in the deterioration of declarative memory. Neurologically passive shunting of excess glucose through alternative cellular metabolic pathways induces atherogenic, vascular lesions, free radicals, leukoencephalopathy and atrophy of the brain and thus leading to cognitive deficits. In physiological conditions insulin has neuroprotective effect. However, insulin resistance in the central nervous system correlates with insulin resistance in the periphery. Loss of responsiveness to insulin could render neurons more susceptible to neurotoxic insults, the protective effect of insulin diminishes, and apoptosis, neurodegeneration and the resultant cognitive decline are all increased in insulin-resistant patients. Some unclear relations appear between diabetes mellitus and Alzheimer's disease. Diabetic patients with APOE-4 gene have an increased risk for Alzheimer's disease. Prevalence of depression is higher in patients with diabetes mellitus and in turn, depression is a risk factor for diabetes mellitus. Simultaneous presence of depression and diabetes mellitus tends to worsen the course of both. PMID:18055361

Aszals, Zsuzsa

2007-12-16

376

Planificacin Neuroquirrgica con Software Osirix  

PubMed Central

Introduccin: La individualidad anatmica es clave para reducir el trauma quirrgico y obtener un mejor resultado. Actualmente, el avance en las neuroimgenes ha permitido objetivar esa individualidad anatmica, permitiendo planificar la intervencin quirrgica. Con este objetivo, presentamos nuestra experiencia con el software Osirix. Descripcin de la tcnica: Se presentan 3 casos ejemplificadores de 40 realizados. Caso 1: Paciente con meningioma de la convexidad parasagital izquierda en rea premotora; Caso 2: Paciente con macroadenoma hipofisario, operada previamente por va transeptoesfenoidal en otra institucin con una reseccin parcial; Caso 3: Paciente con lesiones en pednculo cerebeloso medio bilateral. Se realiz la planificacin prequirrgica con el software OsiriX, fusionando y reconstruyendo en 3D las imgenes de TC e IRM, para analizar relaciones anatmicas, medir distancias, coordenadas y trayectorias, entre otras funciones. Discusin: El software OsiriX de acceso libre y gratuito permite al cirujano, mediante la fusin y reconstruccin en 3D de imgenes, analizar la anatoma individual del paciente y planificar de forma rpida, simple, segura y econmica cirugas de alta complejidad. En el Caso 1 se pudo analizar las relaciones del tumor con las estructuras adyacentes para minimizar el abordaje. En el Caso 2 permiti comprender la anatoma post-operatoria previa del paciente, para determinar la trayectoria del abordaje transnasal endoscpico y la necesidad de ampliar su exposicin, logrando la reseccin tumoral completa. En el Caso 3 permiti obtener las coordenadas estereotxicas y trayectoria de una lesin sin representacin tomogrfica. Conclusin: En casos de no contar con costosos sistemas de neuronavegacin o estereotxia el software OsiriX es una alternativa a la hora de planificar la ciruga, con el objetivo de disminuir el trauma y la morbilidad operatoria. PMID:25165617

Jaimovich, Sebastin Gastn; Guevara, Martin; Pampin, Sergio; Jaimovich, Roberto; Gardella, Javier Luis

2014-01-01

377

Cell Biology: Sorting Out Diabetes  

NSDL National Science Digital Library

Early during the development of type 2 diabetes, insulin's ability to stimulate the cellular uptake of glucose from the blood is compromised. Muscle is the main tissue responsible for this absorption, and insulin enhances glucose movement into muscle cells through the GLUT4 transporter at the cell surface. This hallmark action of insulin is conserved in vertebrates, and the molecular machinery by which it occurs is thought to be similar among mammals. On page 1192 of this issue, Vassilopoulos et al. (4) identify a key protein that mediates insulin action in humans, but not in mice, a distinction with potential implications for understanding glucose metabolism and diabetes pathophysiology.

Charisse M. Orme (Yale University School of Medicine; Section of Endocrinology and Metabolism, Department of Internal Medicine, and Department of Cell Biology)

2009-05-29

378

A Boon for the Diabetic  

NASA Technical Reports Server (NTRS)

Diabetics are no longer concerned with scheduling activities around peaking insulin levels since the use of an external pump from Pacesetter Systems, Inc. used to deliver insulin continuously at a preprogrammed individually adjusted rate. The pump wearer can lead a more normal existence, even participate in sports or travel, and there is an even greater benefit. Research indicates that infusion of "short acting" insulin in tiny amounts over a long period - instead of "long- acting" insulin has helped many diabetics achieve better control of blood sugar levels, thereby minimizing the possibility of complications and, in some cases, even halting the progression of complications.

1987-01-01

379

Ocular complications of diabetes mellitus  

PubMed Central

Diabetes mellitus (DM) is a important health problem that induces ernestful complications and it causes significant morbidity owing to specific microvascular complications such as, retinopathy, nephropathy and neuropathy, and macrovascular complications such as, ischaemic heart disease, and peripheral vasculopathy. It can affect children, young people and adults and is becoming more common. Ocular complications associated with DM are progressive and rapidly becoming the worlds most significant cause of morbidity and are preventable with early detection and timely treatment. This review provides an overview of five main ocular complications associated with DM, diabetic retinopathy and papillopathy, cataract, glaucoma, and ocular surface diseases.

Sayin, Nihat; Kara, Necip; Pekel, Gkhan

2015-01-01

380

[Laser treatment in diabetic retinopathy].  

PubMed

1050 eyes with diabetic retinopathy (670 preproliferatives retinopathies, 380 proliferatives retinopathies), was treated by laser argon photocoagulation. The laser photocoagulation is the election therapeutical method for the zones of neovascular perfusion, after angiofluorographic diagnosis. It is necessary to know very well the therapeutical indications and the correct technique adopted to each type of lesions. Also is necessary to obtain an equilibrium of the diabetic, especially in limitation of high variation of glycemia. In this study 20% of treated cases, was repeated the photocoagulation, and 10% of cases presented complications: vitreous hemorrhages, neovascular glaucoma, retinal detachment. PMID:7766596

Dumitrache, M; Ani?escu, M; Crstocea, B

1995-01-01

381

Ocular complications of diabetes mellitus.  

PubMed

Diabetes mellitus (DM) is a important health problem that induces ernestful complications and it causes significant morbidity owing to specific microvascular complications such as, retinopathy, nephropathy and neuropathy, and macrovascular complications such as, ischaemic heart disease, and peripheral vasculopathy. It can affect children, young people and adults and is becoming more common. Ocular complications associated with DM are progressive and rapidly becoming the world's most significant cause of morbidity and are preventable with early detection and timely treatment. This review provides an overview of five main ocular complications associated with DM, diabetic retinopathy and papillopathy, cataract, glaucoma, and ocular surface diseases. PMID:25685281

Sayin, Nihat; Kara, Necip; Pekel, Gkhan

2015-02-15

382

Ranibizumab in diabetic macular edema  

PubMed Central

By 2050 the prevalence of diabetes will more than triple globally, dramatically increasing the societal and financial burden of this disease worldwide. As a consequence of this growth, it is anticipated that there will be a concurrent rise in the numbers of patients with diabetic macular edema (DME), already among the most common causes of severe vision loss worldwide. Recent available therapies for DME target the secreted cytokine, vascular endothelial growth factor (VEGF). This review focuses on the treatment of DME using the first humanized monoclonal antibody targeting VEGF that has been Food and Drug Administration-approved for the use in the eye, ranibizumab (Lucentis). PMID:24379922

Krispel, Claudia; Rodrigues, Murilo; Xin, Xiaoban; Sodhi, Akrit

2013-01-01

383

Diabetic Retinopathy: Surrogate Outcomes for Drug Development for Diabetic Retinopathy  

Microsoft Academic Search

Diabetic retinopathy remains the most frequent cause of new cases of blindness among adults aged 2074 years. A number of large clinical trials have validated treatment methods now considered standard. However, the disease continues to progress in approximately 50% of the eyes treated by photocoagulation. Other forms of therapy targeted at the earliest stages of retinal disease are needed. The

J. G. Cunha-Vaz

2000-01-01

384

An unusual presentation of diabetic amyotrophy: myoclonus  

PubMed Central

Diabetic amyotrophy is a distinctive form of diabetic neuropathy. It is characterised by a weakness and wasting of proximal muscles of the lower limbs with associated pain. We report a case of an elderly patient with unusual presentation of diabetic amyotrophy. He presented with myoclonic jerks and recurrent falls. Examination findings and electrophysiological studies were consistent with a diagnosis of diabetic amyotrophy. He responded well to steroids with marked improvement in strength of the lower limb muscles and complete resolution of myoclonic jerks. Diabetic amyotrophy presenting as myoclonic jerks has been rarely reported before. PMID:23386493

Zaidi, Syed Amir; Chhetri, Suresh Kumar; Lekwuwa, Godwin; Majeed, Tahir

2013-01-01

385

Managing diabetes in nursing and care homes.  

PubMed

The England-wide Care Home Diabetes Audit, published earlier this year, revealed a lack of assessment, monitoring and specialist care for people with diabetes who live in nursing and care homes. Many homes are not systematically screening residents for diabetes nor monitoring the blood glucose levels of those with the condition. Staff education and training is patchy and patients are at risk of hypoglycaemia and diabetic foot complications. The Institute of Diabetes for Older People, which conducted the audit, has called for tighter regulation to improve care. PMID:25241436

Anderson, Pat

386

Dermatologic manifestations of diabetes mellitus: a review.  

PubMed

Diabetes mellitus affects every organ of the body including the skin. Certain skin manifestations of diabetes are considered cutaneous markers of the disease, whereas others are nonspecific conditions that occur more frequently among individuals with diabetes compared with the general population. Diabetic patients have an increased susceptibility to some bacterial and fungal skin infections, which account, in part, for poor healing. Skin complications of diabetes provide clues to current and past metabolic status. Recognition of cutaneous markers may slow disease progression and ultimately improve the overall prognosis by enabling earlier diagnosis and treatment. PMID:24286954

Murphy-Chutorian, Blair; Han, George; Cohen, Steven R

2013-12-01

387

[Circadian clock disruption and diabetes mellitus].  

PubMed

Recent studies have demonstrated relationships between the dysfunction of circadian clocks and the development of obesity and type 2 diabetes. In humans, both shift work and the genetic variations of clock genes increase the risk of these disorders. In mice, the light conditions which induce chronic jet lag and modifications of the clock genes cause obesity and/or type 2 diabetes. Moreover, circadian clocks in peripheral tissues are impaired in both patients with type 2 diabetes and genetically obese diabetic mice. Therefore, circadian clocks are important new therapeutic targets for preventing and treating obesity and type 2 diabetes. PMID:24437264

Ando, Hitoshi; Fujimura, Akio

2013-12-01

388

Diabetic myonecrosis in a cystic fibrosis patient.  

PubMed

Cystic fibrosis (CF) related diabetes is an increasingly common comorbidity in CF patients, with scarce data on end-stage complications in the CF population. We report the case of a 32-year-old with poorly controlled diabetes presenting with sub-acute leg pain and focal quadriceps tenderness. Neuromuscular testing and extensive workup revealed diabetic myonecrosis. To our knowledge, this is the first reported case of diabetic myonecrosis in a patient with CF, and highlights the need for pulmonary physicians to recognize this diabetic complication in CF patients, which is associated with a poor long-term prognosis and existing microvascular complications. PMID:23362169

Kopp, Benjamin T; Kirkby, Stephen; Hayes, Don; Flanigan, Kevin M

2013-10-01

389

Diabetic myonecrosis: uncommon complications in common diseases.  

PubMed

We report a case of sudden thigh pain from spontaneous quadriceps necrosis, also known as diabetic myonecrosis, in a 28-year-old patient with poorly controlled diabetes mellitus. Diabetic muscle infarction is a rare end-organ complication seen in patients with poor glycemic control and advanced chronic microvascular complications. Proposed mechanisms involve atherosclerotic microvascular occlusion, ischemia-reperfusion related injury, vasculitis with microthrombi formation, and an acquired antiphospholipid syndrome. Diabetic myonecrosis most commonly presents as sudden thigh pain with swelling and should be considered in any patient who has poorly controlled diabetes mellitus. PMID:24716004

Sran, Sisira; Sran, Manpreet; Ferguson, Nicole; Anand, Prachi

2014-01-01

390

Diabetic Myonecrosis: Uncommon Complications in Common Diseases  

PubMed Central

We report a case of sudden thigh pain from spontaneous quadriceps necrosis, also known as diabetic myonecrosis, in a 28-year-old patient with poorly controlled diabetes mellitus. Diabetic muscle infarction is a rare end-organ complication seen in patients with poor glycemic control and advanced chronic microvascular complications. Proposed mechanisms involve atherosclerotic microvascular occlusion, ischemia-reperfusion related injury, vasculitis with microthrombi formation, and an acquired antiphospholipid syndrome. Diabetic myonecrosis most commonly presents as sudden thigh pain with swelling and should be considered in any patient who has poorly controlled diabetes mellitus. PMID:24716004

Sran, Manpreet; Ferguson, Nicole

2014-01-01

391

Diabetes mellitus: its impact on women.  

PubMed

Diabetes mellitus is a serious chronic illness. It affects approximately 16 million people in the United States, half of whom are undiagnosed. The prevalence of non-insulin-dependent diabetes is higher in women than in men, and more women die each year from diabetes than from breast cancer. Its complications, retinopathy, nephropathy, neuropathy and cardiovascular disease, exact a heavy toll on the individual with diabetes, as well as society. Because of its significant morbidity and mortality in women, diabetes deserves a place in the concerns designated "women's health issues." It deserves more research attention and especially more public awareness, since many of its devastating complications can be prevented by improved detection and control. This review examines the available data concerning the impact of diabetes on women, as well as gender differences in the incidence of diabetes and its complications. It will also discuss life cycle issues which are specific to women. PMID:8829698

Wishner, K L

1996-01-01

392

Treatment of painful diabetic neuropathy.  

PubMed

Painful diabetic neuropathy (PDN) is a debilitating consequence of diabetes that may be present in as many as one in five patients with diabetes. The objective assessment of PDN is difficult, making it challenging to diagnose and assess in both clinical practice and clinical trials. No single treatment exists to prevent or reverse neuropathic changes or to provide total pain relief. Treatment of PDN is based on three major approaches: intensive glycaemic control and risk factor management, treatments based on pathogenetic mechanisms, and symptomatic pain management. Clinical guidelines recommend pain relief in PDN through the use of antidepressants such as amitriptyline and duloxetine, the ?-aminobutyric acid analogues gabapentin and pregabalin, opioids and topical agents such as capsaicin. Of these medications, duloxetine and pregabalin were approved by the US Food and Drug Administration (FDA) in 2004 and tapentadol extended release was approved in 2012 for the treatment of PDN. Proposed pathogenetic treatments include ?-lipoic acid (stems reactive oxygen species formation), benfotiamine (prevents vascular damage in diabetes) and aldose-reductase inhibitors (reduces flux through the polyol pathway). There is a growing need for studies to evaluate the most potent drugs or combinations for the management of PDN to maximize pain relief and improve quality of life. A number of agents are potential candidates for future use in PDN therapy, including Nav 1.7 antagonists, N-type calcium channel blockers, NGF antibodies and angiotensin II type 2 receptor antagonists. PMID:25553239

Javed, Saad; Petropoulos, Ioannis N; Alam, Uazman; Malik, Rayaz A

2015-01-01

393

Cereal grains, legumes and diabetes  

Microsoft Academic Search

This review examines the evidence for the role of whole grain foods and legumes in the aetiology and management of diabetes. MedLine and SilverPlatter (Nutrition and Food Science FSTA) databases were searched to identify epidemiological and experimental studies relating to the effects of whole grain foods and legumes on indicators of carbohydrate metabolism. Epidemiological studies strongly support the suggestion that

B J Venn; J I Mann

2004-01-01

394

Mouse Models of Diabetic Neuropathy  

PubMed Central

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and is associated with significant morbidity and mortality. DPN is characterized by progressive, distal-to-proximal degeneration of peripheral nerves that leads to pain, weakness, and eventual loss of sensation. The mechanisms underlying DPN pathogenesis are uncertain, and other than tight glycemic control in type 1 patients, there is no effective treatment. Mouse models of type 1 (T1DM) and type 2 diabetes (T2DM) are critical to improving our understanding of DPN pathophysiology and developing novel treatment strategies. In this review, we discuss the most widely used T1DM and T2DM mouse models for DPN research, with emphasis on the main neurologic phenotype of each model. We also discuss important considerations for selecting appropriate models for T1DM and T2DM DPN studies and describe the promise of novel emerging diabetic mouse models for DPN research. The development, characterization, and comprehensive neurologic phenotyping of clinically relevant mouse models for T1DM and T2DM will provide valuable resources for future studies examining DPN pathogenesis and novel therapeutic strategies. PMID:24615439

O'Brien, Phillipe D.; Sakowski, Stacey A.; Feldman, Eva L.

2014-01-01

395

Diabetes: Models, Signals, and Control  

PubMed Central

The control of diabetes is an interdisciplinary endeavor, which includes a significant biomedical engineering component, with traditions of success beginning in the early 1960s. It began with modeling of the insulin-glucose system, and progressed to large-scale in silico experiments, and automated closed-loop control (artificial pancreas). Here, we follow these engineering efforts through the last, almost 50 years. We begin with the now classic minimal modeling approach and discuss a number of subsequent models, which have recently resulted in the first in silico simulation model accepted as substitute to animal trials in the quest for optimal diabetes control. We then review metabolic monitoring, with a particular emphasis on the new continuous glucose sensors, on the analyses of their time-series signals, and on the opportunities that they present for automation of diabetes control. Finally, we review control strategies that have been successfully employed in vivo or in silico, presenting a promise for the development of a future artificial pancreas and, in particular, discuss a modular architecture for building closed-loop control systems, including insulin delivery and patient safety supervision layers. We conclude with a brief discussion of the unique interactions between human physiology, behavioral events, engineering modeling and control relevant to diabetes. PMID:20936056

Cobelli, Claudio; Man, Chiara Dalla; Sparacino, Giovanni; Magni, Lalo; De Nicolao, Giuseppe; Kovatchev, Boris P.

2010-01-01

396

Treatment of painful diabetic neuropathy  

PubMed Central

Painful diabetic neuropathy (PDN) is a debilitating consequence of diabetes that may be present in as many as one in five patients with diabetes. The objective assessment of PDN is difficult, making it challenging to diagnose and assess in both clinical practice and clinical trials. No single treatment exists to prevent or reverse neuropathic changes or to provide total pain relief. Treatment of PDN is based on three major approaches: intensive glycaemic control and risk factor management, treatments based on pathogenetic mechanisms, and symptomatic pain management. Clinical guidelines recommend pain relief in PDN through the use of antidepressants such as amitriptyline and duloxetine, the ?-aminobutyric acid analogues gabapentin and pregabalin, opioids and topical agents such as capsaicin. Of these medications, duloxetine and pregabalin were approved by the US Food and Drug Administration (FDA) in 2004 and tapentadol extended release was approved in 2012 for the treatment of PDN. Proposed pathogenetic treatments include ?-lipoic acid (stems reactive oxygen species formation), benfotiamine (prevents vascular damage in diabetes) and aldose-reductase inhibitors (reduces flux through the polyol pathway). There is a growing need for studies to evaluate the most potent drugs or combinations for the management of PDN to maximize pain relief and improve quality of life. A number of agents are potential candidates for future use in PDN therapy, including Nav 1.7 antagonists, N-type calcium channel blockers, NGF antibodies and angiotensin II type 2 receptor antagonists. PMID:25553239

Petropoulos, Ioannis N.; Alam, Uazman; Malik, Rayaz A.

2015-01-01

397

Importance of Depression in Diabetes.  

ERIC Educational Resources Information Center

Depression doubles the likelihood of comorbid depression, which presents as major depression in 11% and subsyndromal depression in 31% of patients with the medical illness. The course of depression is chronic, and afflicted patients suffer an average of one episode annually. Depression has unique importance in diabetes because of its association

Lustman, Patrick J.; Clouse, Ray E.; Anderson, Ryan J.

398

A human virus improves diabetes  

Technology Transfer Automated Retrieval System (TEKTRAN)

A single inoculation of mice with Ad36, a human adenovirus, lastingly improved high fat diet-induced-diabetes (DID), while Ad2, another human adenovirus did not. The study objective in these 2 studies was to determine if Ad36 could be used as a tool to reveal novel pathways for improving dysglycemia...

399

Gut Microbiota, Obesity and Diabetes  

Microsoft Academic Search

The growing epidemic of obesity is no longer restricted to developed countries. In 2005, the World Health Organization alerted that there were approximately 400 million obese adults worldwide, and approximately 20 million children worldwide were overweight. Obesity is a complex health issue with serious consequences such as type 2 diabetes, cardiovascular diseases, and others. Behavioral, genetic and environmental factors have

Rodrigo Bibiloni; Mathieu Membrez; Chieh Jason Chou

2009-01-01

400

FLAVONOID THERAPY IN DIABETIC RETINOPATHY  

PubMed Central

A new flavonoid, CVP (citrus vitamin P) had no beneficial effect on diabetic retinopathy in 33 patients. Minor improvement in retinal status occurred in 27 per cent of the patients. This rate of improvement is the same as that previously reported after many different therapies, and probably represents spontaneous variation in the course of this disease. PMID:13618745

Brickley, Paul M.; Gifford, Byron L.; Domz, Casimir A.

1959-01-01

401

Targeting Fat to Prevent Diabetes  

PubMed Central

An emerging view is that obesity causes metabolic problems when adipose tissue fails to meet the increased demands for fat storage. A study in this issue of Cell Metabolism (Waki et al., 2007) has identified harmine as a proadipogenic small molecule that promotes energy expenditure in white adipose tissue and delays the onset of obesity-associated diabetes. PMID:17488634

Sethi, Jaswinder K.; Vidal-Puig, Antonio J.

2015-01-01

402

Masked Hypertension in Diabetes Mellitus  

PubMed Central

Although distinguishing features of masked hypertension in diabetics are well known, the significance of antihypertensive treatment on clinical practice decisions has not been fully explored. We analyzed 9691 subjects from the population-based 11-country International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes. Prevalence of masked hypertension in untreated normotensive participants was higher (P<0.0001) among 229 diabetics (29.3%, n=67) than among 5486 nondiabetics (18.8%, n=1031). Over a median of 11.0 years of follow-up, the adjusted risk for a composite cardiovascular end point in untreated diabetic-masked hypertensives tended to be higher than in normotensives (hazard rate [HR], 1.96; 95% confidence interval [CI], 0.973.97; P=0.059), similar to untreated stage 1 hypertensives (HR, 1.07; CI, 0.581.98; P=0.82), but less than stage 2 hypertensives (HR, 0.53; CI, 0.290.99; P=0.048). In contrast, cardiovascular risk was not significantly different in antihypertensive-treated diabetic-masked hypertensives, as compared with the normotensive comparator group (HR, 1.13; CI, 0.542.35; P=0.75), stage 1 hypertensives (HR, 0.91; CI, 0.491.69; P=0.76), and stage 2 hypertensives (HR, 0.65; CI, 0.351.20; P=0.17). In the untreated diabetic-masked hypertensive population, mean conventional systolic/diastolic blood pressure was 129.28.0/76.07.3 mm Hg, and mean daytime systolic/diastolic blood pressure 141.59.1/83.76.5 mm Hg. In conclusion, masked hypertension occurred in 29% of untreated diabetics, had comparable cardiovascular risk as stage 1 hypertension, and would require considerable reduction in conventional blood pressure to reach daytime ambulatory treatment goal. Importantly, many hypertensive diabetics when receiving antihypertensive therapy can present with normalized conventional and elevated ambulatory blood pressure that mimics masked hypertension. PMID:23478096

Franklin, Stanley S.; Thijs, Lutgarde; Li, Yan; Hansen, Tine W.; Boggia, Jos; Liu, Yanping; Asayama, Kei; Bjrklund-Bodegrd, Kristina; Ohkubo, Takayoshi; Jeppesen, Jrgen; Torp-Pedersen, Christian; Dolan, Eamon; Kuznetsova, Tatiana; Stolarz-Skrzypek, Katarzyna; Tikhonoff, Valrie; Malyutina, Sofia; Casiglia, Edoardo; Nikitin, Yuri; Lind, Lars; Sandoya, Edgardo; Kawecka-Jaszcz, Kalina; Filipovsk, Jan; Imai, Yutaka; Wang, Jiguang; Ibsen, Hans; OBrien, Eoin; Staessen, Jan A.

2013-01-01

403

Morphometric characteristics of placental villi in pregnant women with diabetes.  

PubMed

We conducted a comparative morphological study of placentas from women with gestational diabetes and diabetes mellitus. Morphometry of histological preparations revealed similar type of changes in the studied parameters of placental villi in diabetes mellitus and gestational diabetes. The maximum deviation of the studied parameters from the control was noted in type 1 diabetes mellitus. PMID:22462069

Dubova, E A; Pavlov, K A; Yesayan, R M; Nagovitsyna, M N; Tkacheva, O N; Shestakova, M V; Shchegolev, A I

2011-09-01

404

Providing a Safe Environment for Students with Diabetes  

ERIC Educational Resources Information Center

Current diabetes regimens require more effort than ever before. The level of diabetes control students are able to maintain is affected greatly by their ability to care for their diabetes during the school day. This article reviews use of School Health Plans and Diabetes Medical Management Plans in schools. Students with diabetes, their families,

Silverstein, Janet H.; Jackson, Crystal C.; Bobo, Nichole; Kaufman, Francine R.; Butler, Sarah; Marschilok, Katie

2009-01-01

405

Meal Plans: What Kids with Diabetes Need to Know  

MedlinePLUS

... to Know KidsHealth > Kids > Diabetes Center > Diabetes and Nutrition > Meal Plans: What Kids With Diabetes Need to Know Print A A A Text Size What's in ... diabetes don't need to be on strict diets, but they do need to pay attention ... levels in check. Meal plans help people with diabetes eat right and stay ...

406

Understanding Gestational Diabetes: A Practical Guide to a Healthy Pregnancy.  

ERIC Educational Resources Information Center

This brochure addresses the problem of gestational diabetes and answers the most frequently asked questions about the disease. It begins by defining gestational diabetes and discussing its cause, then addresses such topics as: (1) how gestational diabetes differs from other types of diabetes; (2) who is at risk for developing gestational diabetes

National Inst. of Child Health and Human Development (NIH), Bethesda, MD.

407

Effect of alpha-tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve.  

PubMed

We tested the hypothesis that oxidative stress can cause neuropathy by evaluating the effect of alpha-tocopherol depletion in normal and streptozotocin (STZ) diabetic peripheral nerve (known to be subject to oxidative stress). The end points were nerve electrophysiology and indices of oxidative stress. Studies were done on 6 groups of rats at 1 and 3 months: (1) Controls, normal alpha-tocopherol (Con[N]). (2) Controls, alpha-tocopherol-deficient (Con[-]) (3) Controls, alpha-tocopherol supplemented (Con[+]); (4) Diabetic, normal alpha-tocopherol (STZ[N]); (5) Diabetic, alpha-tocopherol-deficient (STZ[-]) (6) Diabetic, alpha-tocopherol supplemented (STZ[+]). An alpha-tocopherol-deficient diet resulted in a rapid depletion of the vitamin in plasma and sympathetic neurones (superior cervical ganglion), and a slower depletion in sensory neurones (dorsal root ganglion) and nerve. The depletion was associated with a reduction in reduced glutathione and an increase in conjugated dienes and hydroperoxides in normal rats, and resulted in similar changes, or accentuated the abnormalities, in diabetic nerves. Changes were more pronounced at 1 than 3 months and alpha-tocopherol supplementation, for the most part, did not prevent the abnormalities. alpha-Tocopherol depletion induced or worsened nerve conduction abnormalities in both sciatic-tibial and caudal nerves. Sensory fibers were more affected than motor fibers and the changes were more pronounced at 3 than 1 month. These findings support the notion that oxidative stress may cause neuropathy and that it might be mechanistically implicated in experimental diabetic neuropathy (STZ-EDN). PMID:7836948

Nickander, K K; Schmelzer, J D; Rohwer, D A; Low, P A

1994-10-01

408

Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes.  

PubMed

Hispanics are at increased risk of morbidity and mortality due to their high prevalence of diabetes and poor glycemic control. Strength training is the most effective lifestyle intervention to increase muscle mass but limited data is available in older adults with diabetes. We determined the influence of strength training on muscle quality (strength per unit of muscle mass), skeletal muscle fiber hypertrophy, and metabolic control including insulin resistance (Homeostasis Model Assessment -HOMA-IR), C-Reactive Protein (CRP), adiponectin and Free Fatty Acid (FFA) levels in Hispanic older adults. Sixty-two community-dwelling Hispanics (>55 y) with type 2 diabetes were randomized to 16 weeks of strength training plus standard care (ST group) or standard care alone (CON group). Skeletal muscle biopsies and biochemical measures were taken at baseline and 16 weeks. The ST group show improved muscle quality (mean+/-SE: 28+/-3) vs CON (-4+/-2, p<0.001) and increased type I (860+/-252 microm(2)) and type II fiber cross-sectional area (720+/-285 microm(2)) compared to CON (type I: -164+/-290 microm(2), p=0.04; and type II: -130+/-336 microm(2), p=0.04). This was accompanied by reduced insulin resistance [ST: median (interquartile range) -0.7(3.6) vs CON: 0.8(3.8), p=0.05]; FFA (ST: -84+/-30 micromol/L vs CON: 149+/-48 micromol/L, p=0.02); and CRP [ST: -1.3(2.9) mg/L vs CON: 0.4(2.3) mg/L, p=0.05]. Serum adiponectin increased with ST [1.0(1.8) microg/mL] compared to CON [-1.2(2.2) microg/mL, p<0.001]. Strength training improved muscle quality and whole-body insulin sensitivity. Decreased inflammation and increased adiponectin levels were related with improved metabolic control. Further studies are needed to understand the mechanisms associated with these findings. However, these data show that strength training is an exercise modality to consider as an adjunct of standard of care in high risk populations with type 2 diabetes. PMID:17211497

Brooks, Naomi; Layne, Jennifer E; Gordon, Patricia L; Roubenoff, Ronenn; Nelson, Miriam E; Castaneda-Sceppa, Carmen

2007-01-01

409

Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes  

PubMed Central

Hispanics are at increased risk of morbidity and mortality due to their high prevalence of diabetes and poor glycemic control. Strength training is the most effective lifestyle intervention to increase muscle mass but limited data is available in older adults with diabetes. We determined the influence of strength training on muscle quality (strength per unit of muscle mass), skeletal muscle fiber hypertrophy, and metabolic control including insulin resistance (Homeostasis Model Assessment HOMA-IR), C-Reactive Protein (CRP), adiponectin and Free Fatty Acid (FFA) levels in Hispanic older adults. Sixty-two community-dwelling Hispanics (>55 y) with type 2 diabetes were randomized to 16 weeks of strength training plus standard care (ST group) or standard care alone (CON group). Skeletal muscle biopsies and biochemical measures were taken at baseline and 16 weeks. The ST group show improved muscle quality (meanSE: 283) vs CON (-42, p<0.001) and increased type I (860252m2) and type II fiber cross-sectional area (720285m2) compared to CON (type I: -164290m2, p=0.04; and type II: -130336m2, p=0.04). This was accompanied by reduced insulin resistance [ST: median (interquartile range) -0.7(3.6) vs CON: 0.8(3.8), p=0.05]; FFA (ST: -8430mol/L vs CON: 14948mol/L, p=0.02); and CRP [ST: -1.3(2.9)mg/L vs CON: 0.4(2.3)mg/L, p=0.05]. Serum adiponectin increased with ST [1.0(1.8)g/mL] compared to CON [-1.2(2.2)g/mL, p<0.001]. Strength training improved muscle quality and whole-body insulin sensitivity. Decreased inflammation and increased adiponectin levels were related with improved metabolic control. Further studies are needed to understand the mechanisms associated with these findings. However, these data show that strength training is an exercise modality to consider as an adjunct of standard of care in high risk populations with type 2 diabetes. PMID:17211497

Brooks, Naomi; Layne, Jennifer E.; Gordon, Patricia L.; Roubenoff, Ronenn; Nelson, Miriam E.; Castaneda-Sceppa, Carmen

2007-01-01

410

The Diabetic Lung - A New Target Organ?  

PubMed Central

Several abnormalities of the respiratory function have been reported in patients with type 1 and type 2 diabetes. These abnormalities concern lung volume, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Many hypotheses have emerged, and characteristic histological changes have been described in the "diabetic lung", which could explain this abnormal respiratory function. Given the specific abnormalities in diabetic patients, the lung could thus be considered as a target organ in diabetes. Although the practical implications of these functional changes are mild, the presence of an associated acute or chronic pulmonary and/or cardiac disease could determine severe respiratory derangements in diabetic patients. Another clinical consequence of the pulmonary involvement in diabetes is the accelerated decline in respiratory function. The rate of decline in respiratory function in diabetics has been found to be two-to-three times faster than in normal non-smoking subjects, as reported in longitudinal studies. This finding, together with the presence of anatomical and biological changes similar to those described in the aging lung, indicates that the "diabetic lung" could even be considered a model of accelerated aging. This review describes and analyses the current insight into the relationship of diabetes and lung disease, and suggests intensifying research into the lung as a possible target organ in diabetes. PMID:22972442

Pitocco, Dario; Fuso, Leonello; Conte, Emanuele G.; Zaccardi, Francesco; Condoluci, Carola; Scavone, Giuseppe; Incalzi, Raffaele Antonelli; Ghirlanda, Giovanni

2012-01-01

411

Diabetes and sexual dysfunction: current perspectives  

PubMed Central

Diabetes mellitus is one of the most common chronic diseases in nearly all countries. It has been associated with sexual dysfunction, both in males and in females. Diabetes is an established risk factor for sexual dysfunction in men, as a threefold increased risk of erectile dysfunction was documented in diabetic men, as compared with nondiabetic men. Among women, evidence regarding the association between diabetes and sexual dysfunction are less conclusive, although most studies have reported a higher prevalence of female sexual dysfunction in diabetic women as compared with nondiabetic women. Female sexual function appears to be more related to social and psychological components than to the physiological consequence of diabetes. Hyperglycemia, which is a main determinant of vascular and microvascular diabetic complications, may participate in the pathogenetic mechanisms of sexual dysfunction in diabetes. Moreover, diabetic people may present several clinical conditions, including hypertension, overweight and obesity, metabolic syndrome, cigarette smoking, and atherogenic dyslipidemia, which are themselves risk factors for sexual dysfunction, both in men and in women. The adoption of healthy lifestyles may reduce insulin resistance, endothelial dysfunction, and oxidative stress all of which are desirable achievements in diabetic patients. Improved well-being may further contribute to reduce and prevent sexual dysfunction in both sexes. PMID:24623985

Maiorino, Maria Ida; Bellastella, Giuseppe; Esposito, Katherine

2014-01-01

412

Evaluation of a community Diabetes Prevention Program delivered by diabetes educators in the United States: One-year follow up.  

PubMed

Strategies for management of pre-diabetes within the community setting are needed. An adaptation of the successful Diabetes Prevention Program lifestyle intervention delivered by trained diabetes educators was evaluated. Results indicate that trained diabetes educators offer an important community resource for health care providers for their patients with pre-diabetes. PMID:25467620

Kramer, M Kaye; Miller, Rachel G; Siminerio, Linda M

2014-12-01

413

Cost-Effectiveness Analysis of Type 2 Diabetes Disease Management in District Hospital Context: An Analysis Using CORE Diabetes Model  

Microsoft Academic Search

Abstract Type 2 diabetes is a chronic disease which is a major health problem. Currently, the American Diabetes Association published clinical practice recommendations for diabetes care, prevention and management of complicationsand treatment goal. However, diabetes care in Thailand has not been complied with the guideline particularly in district hospitals due to limited resource. More than 50% of diabetic patients do

? '?; Stephane Roze; Willium J Valentine; Andrew J Palmer; Pataranuch Rujirawat; Thananan Rattanachotphanit; Chulaporn Limwattananon; Supachai Chirakup; Nathorn Chaiyakunapruk; Sumon Sakolchai

414

Self monitoring of blood glucose - a survey of diabetes UK members with type 2 diabetes who use SMBG  

Microsoft Academic Search

BACKGROUND: Aim - to survey members of Diabetes UK who had Type 2 diabetes and who used self monitoring of blood glucose (SMBG), to elicit their views on its usefulness in the management of their diabetes, and how they used the results. A questionnaire was developed for the Diabetes UK website. The questionnaire was posted on the Diabetes UK website

Katharine D Barnard; Amanda J Young; Norman R Waugh

2010-01-01

415

Diabetes City: How Urban Game Design Strategies Can Help Diabetics  

NASA Astrophysics Data System (ADS)

Computer Games are about to leave their electronic shells and enter the city. So-called Serious Pervasive Games (SPGs) [1] allow for hybrid - simultaneously physical and virtual - experiences, applying technologies of ubiquitous computing, communication and intelligent interfaces. They begin to focus on non-entertaining purposes. The following article a) presents game design strategies as a missing link between pervasive computing, Ambient Intelligence and users everyday life. Therefore it spurs a discussion how Pervasive Healthcare focusing on the therapy and prevention of chronic diseases can benefit from urban game design strategies. b) Moreover the article presents the development and work in progress of DiabetesCity - an educational game prototype for young diabetics.

Knll, Martin

416

Hexokinase cellular trafficking in ischemia-reperfusion and ischemic preconditioning is altered in type I diabetic heart.  

PubMed

Diabetes mellitus (DM) has been reported to alter the cardiac response to ischemia-reperfusion (IR). In addition, cardioprotection induced by ischemic preconditioning (IPC) is often impaired in diabetes. We have previously shown that the subcellular localisation of the glycolytic enzyme hexokinase (HK) is causally related to IR injury and IPC protective potential. Especially the binding of HK to mitochondria and prevention of HK solubilisation (HK detachment from mitochondria) during ischemia confers cardioprotection. It is unknown whether diabetes affects HK localisation during IR and IPC as compared to non-diabetes. In this study we hypothesize that DM alters cellular trafficking of hexokinase in response to IR and IPC, possibly explaining the altered response to IR and IPC in diabetic heart. Control (CON) and type I diabetic (DM) rat hearts (65 mg/kg streptozotocin, 4 weeks) were isolated and perfused in Langendorff-mode and subjected to 35 min I and 30 min R with or without IPC (3 times 5 min I). Cytosolic and mitochondrial fractions were obtained at (1) baseline, i.e. after IPC but before I, (2) 35 min I, (3) 5 min R and (4) 30 min R. DM improved rate-pressure product recovery (RPP; 71 10 % baseline (DM) versus 9 1 % baseline (CON) and decreased contracture (end-diastolic pressure: 24 8 mmHg (DM) vs 77 4 mmHg (CON)) after IR as compared to control, and was associated with prevention of HK solubilisation at 35 min I. IPC improved cardiac function in CON but not in DM hearts. IPC in CON prevented HK solubilisation at 35 min I and at 5 min R, with a trend for increased mitochondrial HK. In contrast, the non-effective IPC in DM was associated with solubilisation of HK and decreased mitochondrial HK at early reperfusion and a reciprocal behaviour at late reperfusion. We conclude that type I DM significantly altered cellular HK translocation patterns in the heart in response to IR and IPC, possibly explaining altered response to IR and IPC in diabetes. PMID:23652994

Gurel, Ebru; Ustunova, Savas; Kapucu, Aysegul; Yilmazer, Nadim; Eerbeek, Otto; Nederlof, Rianne; Hollmann, Markus W; Demirci-Tansel, Cihan; Zuurbier, Coert J

2013-07-01

417

Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence  

E-print Network

Abstract Background Tuberculosis (TB) remains a major cause of mortality in developing countries, and in these countries diabetes prevalence is increasing rapidly. Diabetes increases the risk of TB. Our aim was to assess the potential impact...

Stevenson, Catherine R; Forouhi, Nita G; Roglic, Gojka; Williams, Brian G; Lauer, Jeremy A; Dye, Christopher; Unwin, Nigel

2007-09-06

418

Smart Diabetic Socks: Embedded device for diabetic foot prevention  

E-print Network

1) Objectives Most foot ulcers are the consequence of a trauma (repetitive high stress, ill-fitting footwear, or an object inside the shoe) associated to diabetes. They are often followed by amputation and shorten life expectancy. This paper describes the prototype of the Smart Diabetic Socks that has been developed in the context of the French ANR TecSan project. The objective is to prevent pressure foot ulcers for diabetic persons. 2) Material and methods A fully wireless, customizable and washable "smart sock" has been designed. It is made of a textile which fibers are knitted in a way they provide measurements of the pressure exerted under and all around the foot in real-life conditions. This device is coupled with a subject-specific Finite Element foot model that simulates the internal strains within the soft tissues of the foot. 3) Results A number of derived stress indicators can be computed based on that analysis, such as the accumulated stress dose, high internal strains or peak pressures near bony p...

Perrier, Antoine; Luboz, Vincent; Bucki, Marek; Cannard, Francis; Diot, Bruno; Colin, Denis; Rin, Delphine; Bourg, Jean-Philippe; Payan, Yohan

2014-01-01

419

Association between diabetes mellitus with metabolic syndrome and diabetic microangiopathy  

PubMed Central

The aim of this study was to investigate the association between diabetes mellitus (DM), mainly type II, with metabolic syndrome (MS) and diabetic nephropathy (DN)/diabetic retinopathy (DR). Based on the analysis of the prevalence of MS, patients with DM were divided into MS and non-MS groups according to the presence or absence of MS. The correlation between DN, DR and certain factors, including gender, age, disease duration and the presence or absence of a family history of MS, were analyzed. The prevalence of MS among the patients with DM was 62.50%. The prevalence of DN was 55.33% in the MS group and that of DR was 26.00%. DN was positively correlated with age, gender, blood pressure, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and blood uric acid. DR was positively correlated with traceable disease duration and LDL-C. In conclusion, DM occurred more frequently in concurrence with MS than without MS, and the prevalence of DN/DR in the MS group was higher than that in the non-MS group. Age, gender, blood pressure, TG, LDL-C and blood uric acid were risk factors for DN and the traceable disease duration and LDL-C were risk factors for DR. PMID:25371746

ZHANG, XIAOYAN; CUI, XIAOLI; LI, FENGHUA; WANG, SHUO; LIU, XINYU; HUI, LICHAO; SONG, NA; LI, NANNAN

2014-01-01

420

Gestational diabetes mellitus: Get, set, go From diabetes capital of the world to diabetes care capital of the world  

PubMed Central

Screening and diagnosis for gestational diabetes mellitus (GDM) as well as interventions for its management evoke considerable controversy. There are different types of screening methods: universal or risk-based, one step or two step. Different thresholds for diagnosis of GDM have been in vogue. Previous definition and diagnostic criteria had no place for diagnosis of overt diabetes in pregnancy. Following Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study and International Association of Diabetes and Pregnancy Study Groups (IADPSG) recommendations, new screening and diagnostic criteria around the world seem to be gaining consensus. The present recommendation given by IADPSG for screening and diagnosis of diabetes mellitus in pregnancy has two discrete phases. The first is detection of women with overt diabetes not previously diagnosed or treated outside of pregnancy. Universal early testing in populations is recommended at the first prenatal visit. The second phase is a 75-g OGTT at 2428 week gestation in all women not previously found to have overt diabetes or GDM. ACHOIS and MFMU Network trails have proven benefit in treating hyperglycemias less than what is diagnostic for diabetes. DIPSI has shown the alternative way for resource-challenged communities. Efforts from all stake holders with interest in GDM are required to make the diabetes capital of the world into the diabetes care capital of the world. PMID:21897891

Magon, Navneet

2011-01-01

421

A novel case of diabetic muscle necrosis in a patient with cystic fibrosis-related diabetes.  

PubMed

Cystic fibrosis is a recessive autosomal disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene. Cystic fibrosis-related diabetes (CFRD) is a common comorbidity of cystic fibrosis. Diabetic myonecrosis is a rare self-limited complication of poorly controlled diabetes mellitus that commonly presents with acute, intense pain and swelling of lower extremities and responds well to conservative management. We report the first case of diabetic myonecrosis in a patient with CFRD. PMID:23656801

Chalasani, Sreelatha; Bettadahalli, Shankar S; Bhupathi, Satya V; Aswani, Vijay H

2013-09-01

422

Pathogenesis of diabetic cerebral vascular disease complication.  

PubMed

Diabetes mellitus is one of the most potent independent risk factors for the development of diabetic cerebral vascular disease (CVD). Many evidences suggested that hyperglycemia caused excess free fatty acids, the loss of endothelium-derived nitric oxide, insulin resistance, the prothrombotic state, endothelial dysfunction, the abnormal release of endothelial vasoactivators, vascular smooth muscle dysfunction, oxidative stress, and the downregulation of miRs participated in vessel generation and recovery as well as the balance of endotheliocytes. In turn, these abnormalities, mainly via phosphatidylinositol 3 kinase, mitogen-activated protein kinase, polyol, hexosamine, protein kinase C activation, and increased generation of advanced glycosylation end products pathway, play an important role in inducing diabetic CVD complication. A deeper comprehension of pathogenesis producing diabetic CVD could offer base for developing new therapeutic ways preventing diabetic CVD complications, therefore, in the paper we mainly reviewed present information about the possible pathogenesis of diabetic CVD complication. PMID:25685278

Xu, Ren-Shi

2015-02-15

423

Pathogenesis of diabetic cerebral vascular disease complication  

PubMed Central

Diabetes mellitus is one of the most potent independent risk factors for the development of diabetic cerebral vascular disease (CVD). Many evidences suggested that hyperglycemia caused excess free fatty acids, the loss of endothelium-derived nitric oxide, insulin resistance, the prothrombotic state, endothelial dysfunction, the abnormal release of endothelial vasoactivators, vascular smooth muscle dysfunction, oxidative stress, and the downregulation of miRs participated in vessel generation and recovery as well as the balance of endotheliocytes. In turn, these abnormalities, mainly via phosphatidylinositol 3 kinase, mitogen-activated protein kinase, polyol, hexosamine, protein kinase C activation, and increased generation of advanced glycosylation end products pathway, play an important role in inducing diabetic CVD complication. A deeper comprehension of pathogenesis producing diabetic CVD could offer base for developing new therapeutic ways preventing diabetic CVD complications, therefore, in the paper we mainly reviewed present information about the possible pathogenesis of diabetic CVD complication.

Xu, Ren-Shi

2015-01-01

424

Curcumin and Diabetes: A Systematic Review  

PubMed Central

Turmeric (Curcuma longa), a rhizomatous herbaceous perennial plant of the ginger family, has been used for the treatment of diabetes in Ayurvedic and traditional Chinese medicine. The active component of turmeric, curcumin, has caught attention as a potential treatment for diabetes and its complications primarily because it is a relatively safe and inexpensive drug that reduces glycemia and hyperlipidemia in rodent models of diabetes. Here, we review the recent literature on the applications of curcumin for glycemia and diabetes-related liver disorders, adipocyte dysfunction, neuropathy, nephropathy, vascular diseases, pancreatic disorders, and other complications, and we also discuss its antioxidant and anti-inflammatory properties. The applications of additional curcuminoid compounds for diabetes prevention and treatment are also included in this paper. Finally, we mention the approaches that are currently being sought to generate a super curcumin through improvement of the bioavailability to bring this promising natural product to the forefront of diabetes therapeutics. PMID:24348712

Zhang, Dong-wei; Fu, Min; Gao, Si-Hua; Liu, Jun-Li

2013-01-01

425

Perinatal outcomes in type 2 diabetes.  

PubMed

Over the past decade the prevalence of type 2 diabetes in pregnancy has continued to increase. It is vital that health care professionals recognize that preconception care is just as important for mothers with type 2 diabetes as it is in type 1 diabetes. All women with type 2 diabetes should be advised regarding safe effective contraception and the benefits of optimal glycemic control, folic acid supplementation, and avoidance of potentially harmful mediations before attempting pregnancy. Glycemic control is the most important modifiable risk factor for congenital anomaly in women with type 2 diabetes, whereas maternal obesity and social disadvantage are associated with large for gestational age neonates. This review aims to bring the reader up to date with the burden of perinatal outcomes and clinical interventions to improve maternal and infant health. It warns that the consequences of type 2 diabetes pregnancy do not end at birth. PMID:24395435

Hewapathirana, Niranjala M; Murphy, Helen R

2014-02-01

426

77 FR 36333 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-06-18

427

76 FR 17475 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-03-29

428

76 FR 34127 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-06-10

429

77 FR 56258 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-09-12

430

75 FR 25919 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...applications for exemptions from the diabetes mellitus standard; request for comments...prohibition for persons with insulin-treated diabetes mellitus (ITDM) operating...

2010-05-10

431

75 FR 77947 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2010-12-14

432

76 FR 61140 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-10-03

433

76 FR 78720 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-12-19

434

77 FR 18302 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-03-27

435

76 FR 1496 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-01-10

436

78 FR 38435 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-06-26

437

42 CFR 410.146 - Diabetes outcome measurements.  

Code of Federal Regulations, 2011 CFR

... 2011-10-01 2011-10-01 false Diabetes outcome measurements. 410.146 Section...MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements 410.146...

2011-10-01

438

75 FR 64394 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from...

2010-10-19

439

77 FR 63411 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-10-16

440

77 FR 5870 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-02-06

441

76 FR 17478 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-03-29

442

78 FR 26419 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-05-06

443

76 FR 72031 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...against persons with insulin-treated diabetes mellitus (ITDM) operating commercial...requested such an exemption from the diabetes prohibition in 49 CFR...

2011-11-21

444

78 FR 78479 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...against persons with insulin- treated diabetes mellitus (ITDM) operating commercial...requested such an exemption from the diabetes prohibition in 49 CFR...

2013-12-26

445

76 FR 20073 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-04-11

446

77 FR 10612 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-02-22

447

42 CFR 410.146 - Diabetes outcome measurements.  

Code of Federal Regulations, 2014 CFR

... 2014-10-01 2014-10-01 false Diabetes outcome measurements. 410.146 Section...MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements 410.146...

2014-10-01

448

75 FR 63536 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2010-10-15

449

78 FR 65034 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...against persons with insulin- treated diabetes mellitus (ITDM) operating commercial...requested such an exemption from the diabetes prohibition in 49 CFR...

2013-10-30

450

77 FR 33554 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...against persons with insulin-treated diabetes mellitus (ITDM) operating commercial...requested such an exemption from the diabetes prohibition in 49 CFR...

2012-06-06

451

75 FR 34206 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2010-06-16

452

75 FR 42477 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2010-07-21

453

42 CFR 410.146 - Diabetes outcome measurements.  

Code of Federal Regulations, 2013 CFR

... 2013-10-01 2013-10-01 false Diabetes outcome measurements. 410.146 Section...MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements 410.146...

2013-10-01

454

76 FR 34130 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-06-10

455

78 FR 19798 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from 19...

2013-04-02

456

78 FR 79062 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-12-27

457

77 FR 533 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-01-05

458

78 FR 63280 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...against persons with insulin- treated diabetes mellitus (ITDM) operating commercial...requested such an exemption from the diabetes prohibition in 49 CFR...

2013-10-23

459

78 FR 63295 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...against persons with insulin- treated diabetes mellitus (ITDM) operating commercial...requested such an exemption from the diabetes prohibition in 49 CFR...

2013-10-23

460

42 CFR 410.146 - Diabetes outcome measurements.  

Code of Federal Regulations, 2012 CFR

... 2012-10-01 2012-10-01 false Diabetes outcome measurements. 410.146 Section...MEDICAL INSURANCE (SMI) BENEFITS Outpatient Diabetes Self-Management Training and Diabetes Outcome Measurements 410.146...

2012-10-01

461

76 FR 25769 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-05-05

462

77 FR 74271 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-12-13

463

78 FR 76397 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from 16...

2013-12-17

464

76 FR 79756 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-12-22

465

76 FR 47290 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from...

2011-08-04

466

78 FR 50486 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-08-19

467

75 FR 52809 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2010-08-27

468

77 FR 48587 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-08-14

469

77 FR 52384 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-08-29

470

76 FR 32012 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-06-02

471

75 FR 50797 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a Notice of receipt of Federal diabetes exemption applications from twenty...

2010-08-17

472

76 FR 71111 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from sixteen...

2011-11-16

473

75 FR 59788 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2010-09-28

474

76 FR 66120 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-10-25

475

77 FR 65931 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-10-31

476

77 FR 13686 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-03-07

477

78 FR 16032 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-03-13

478

77 FR 59447 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-09-27

479

77 FR 64585 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from 28...

2012-10-22

480

78 FR 16758 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-03-18

481

76 FR 71112 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-11-16

482

78 FR 38439 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-06-26

483

76 FR 5243 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from...

2011-01-28

484

76 FR 22940 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from...

2011-04-25

485

Your Guide to Diabetes: Type 1 and Type 2  

MedlinePLUS

... Info Statistics Research Resources About Us Espaol National Diabetes Information Clearinghouse Publications Tools and Resources E-News ... Type 1 and Type 2 Your Guide to Diabetes: Type 1 and Type 2 Learn about Diabetes ...

486

77 FR 40941 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-07-11

487

Preventing Diabetes Problems: What You Need to Know  

MedlinePLUS

... Info Statistics Research Resources About Us Espaol National Diabetes Information Clearinghouse Publications Tools and Resources E-News ... Diabetes Problems: What You Need to Know Preventing Diabetes Problems: What You Need to Know On this ...

488

78 FR 32704 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-05-31

489

78 FR 1927 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-01-09

490

78 FR 1923 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-01-09

491

78 FR 60014 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial...published a notice of receipt of Federal diabetes exemption applications from 16...

2013-09-30

492

75 FR 52813 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2010-08-27

493

76 FR 55460 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-09-07

494

78 FR 24795 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-04-26

495

78 FR 7852 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2013-02-04

496

78 FR 64267 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...against persons with insulin- treated diabetes mellitus (ITDM) operating commercial...requested such an exemption from the diabetes prohibition in 49 CFR...

2013-10-28

497

78 FR 63285 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...against persons with insulin- treated diabetes mellitus (ITDM) operating commercial...requested such an exemption from the diabetes prohibition in 49 CFR...

2013-10-23

498

76 FR 9854 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus standard; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-02-22

499

76 FR 78725 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2011-12-19

500

77 FR 64181 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus  

Federal Register 2010, 2011, 2012, 2013, 2014

...of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier...of applications for exemption from the diabetes mellitus requirement; request for comments...against persons with insulin-treated diabetes mellitus (ITDM) operating...

2012-10-18