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Sample records for nuclear mater, agencia brasil-argentina contabil controle

  1. From Virgil to Alma Mater

    ERIC Educational Resources Information Center

    Spitz, Ellen Handler

    2007-01-01

    For a college to become an alma mater in the hearts of its students, it must show, true to the Latin meaning, the wisdom and comfort of a good foster mother. Since "alma mater" is Latin, and since the study of Latin has waned on all educational levels in both pious and secular milieus, the author wonders whether folks who use that term really know…

  2. NUCLEAR REACTOR CONTROL SYSTEM

    DOEpatents

    Epler, E.P.; Hanauer, S.H.; Oakes, L.C.

    1959-11-01

    A control system is described for a nuclear reactor using enriched uranium fuel of the type of the swimming pool and other heterogeneous nuclear reactors. Circuits are included for automatically removing and inserting the control rods during the course of normal operation. Appropriate safety circuits close down the nuclear reactor in the event of emergency.

  3. [Nurses and the Mercosul regulations and control of professional practice].

    PubMed

    Vieira, A L

    1998-01-01

    A study comparing the regulation and control of the professional practice of nurses in Brasil, Argentina, Uruguay and Paraguay, delineating their particularities, differences and similarities in the perspective of the implementation of the Cone Sul Common Market, which presupposes the free circulation of workers in the workplaces of the member-countries of the Ascnsion Treaty. PMID:10776275

  4. Nuclear reactor control apparatus

    DOEpatents

    Sridhar, Bettadapur N.

    1983-11-01

    Nuclear reactor core safety rod release apparatus comprises a control rod having a detent notch in the form of an annular peripheral recess at its upper end, a control rod support tube for raising and lowering the control rod under normal conditions, latches pivotally mounted on the control support tube with free ends thereof normally disposed in the recess in the control rod, and cam means for pivoting the latches out of the recess in the control rod when a scram condition occurs. One embodiment of the invention comprises an additional magnetically-operated latch for releasing the control rod under two different conditions, one involving seismic shock.

  5. Controlling nuclear proliferation

    SciTech Connect

    Sweet, W.

    1981-07-17

    Nuclear non-proliferation policy depends on the 1968 Non-Proliferation Treaty, in which countries promise not to acquire nuclear weapons in exchange for open access to peaceful nuclear technology, and a system of international safeguards that are imposed on exported nuclear equipment and facilities operated by parties to the treaty. Critics have feared all along that non-nuclear countries might circumvent or exploit the system to obtain nuclear weapons and that the Atoms for Peace plan would spread the very technology it sought to control. The nuclear weapons states would like everyone else to believe that atomic bombs are undesirable, but they continue to rely on the bombs for their own defense. Israel's raid on Iraq's nuclear reactor focused world attention on the proliferation problem and helped to broaden and sterengthen its prospects. It also highlighted the weakness that there are no effective sanctions against violators. Until the international community can ageee on enforcement measures powerful enough to prevent nuclear proliferation, individual countries may be tempted to follow Israel's example, 19 references.

  6. Nuclear reactor control

    SciTech Connect

    Ingham, R.V.

    1980-01-01

    A liquid metal cooled fast breeder nuclear reactor has power setback means for use in an emergency. On initiation of a trip-signal a control rod is injected into the core in two stages, firstly, by free fall to effect an immediate power-set back to a safe level and, secondly, by controlled insertion. Total shut-down of the reactor under all emergencies is avoided. 4 claims.

  7. Nuclear reactor control

    DOEpatents

    Cawley, William E.; Warnick, Robert F.

    1982-01-01

    1. In a nuclear reactor incorporating a plurality of columns of tubular fuel elements disposed in horizontal tubes in a mass of graphite wherein water flows through the tubes to cool the fuel elements, the improvement comprising at least one control column disposed in a horizontal tube including fewer fuel elements than in a normal column of fuel elements and tubular control elements disposed at both ends of said control column, and means for varying the horizontal displacement of the control column comprising a winch at the upstream end of the control column and a cable extending through the fuel and control elements and attached to the element at the downstream end of the column.

  8. Nuclear reactor control column

    SciTech Connect

    Bachovchin, D.M.

    1982-08-10

    The nuclear reactor control column comprises a column disposed within the nuclear reactor core having a variable cross-section hollow channel and containing balls whose vertical location is determined by the flow of the reactor coolant through the column. The control column is divided into three basic sections wherein each of the sections has a different cross-sectional area. The uppermost section of the control column has the greatest crosssectional area, the intermediate section of the control column has the smallest cross-sectional area, and the lowermost section of the control column has the intermediate cross-sectional area. In this manner, the area of the uppermost section can be established such that when the reactor coolant is flowing under normal conditions therethrough, the absorber balls will be lifted and suspended in a fluidized bed manner in the upper section. However, when the reactor coolant flow falls below a predetermined value, the absorber balls will fall through the intermediate section and into the lowermost section, thereby reducing the reactivity of the reactor core and shutting down the reactor.

  9. Nuclear reactor control column

    DOEpatents

    Bachovchin, Dennis M.

    1982-01-01

    The nuclear reactor control column comprises a column disposed within the nuclear reactor core having a variable cross-section hollow channel and containing balls whose vertical location is determined by the flow of the reactor coolant through the column. The control column is divided into three basic sections wherein each of the sections has a different cross-sectional area. The uppermost section of the control column has the greatest cross-sectional area, the intermediate section of the control column has the smallest cross-sectional area, and the lowermost section of the control column has the intermediate cross-sectional area. In this manner, the area of the uppermost section can be established such that when the reactor coolant is flowing under normal conditions therethrough, the absorber balls will be lifted and suspended in a fluidized bed manner in the upper section. However, when the reactor coolant flow falls below a predetermined value, the absorber balls will fall through the intermediate section and into the lowermost section, thereby reducing the reactivity of the reactor core and shutting down the reactor.

  10. NUCLEAR REACTOR CONTROL SYSTEM

    DOEpatents

    Howard, D.F.; Motta, E.E.

    1961-06-27

    A method for controlling the excess reactivity in a nuclear reactor throughout the core life while maintaining the neutron flux distribution at the desired level is described. The control unit embodies a container having two electrodes of different surface area immersed in an electrolytic solution of a good neutron sbsorbing metal ion such as boron, gadolinium, or cadmium. Initially, the neutron absorber is plated on the larger electrode to control the greater neutron flux of a freshly refueled core. As the fuel burns up, the excess reactivity decreases and the neutron absorber is then plated onto the smaller electrode so that the number of neutrons absorbed also decreases. The excess reactivity in the core may thus be maintained without the introduction of serious perturbations in the neutron flux distributibn.

  11. Global nuclear material control model

    SciTech Connect

    Dreicer, J.S.; Rutherford, D.A.

    1996-05-01

    The nuclear danger can be reduced by a system for global management, protection, control, and accounting as part of a disposition program for special nuclear materials. The development of an international fissile material management and control regime requires conceptual research supported by an analytical and modeling tool that treats the nuclear fuel cycle as a complete system. Such a tool must represent the fundamental data, information, and capabilities of the fuel cycle including an assessment of the global distribution of military and civilian fissile material inventories, a representation of the proliferation pertinent physical processes, and a framework supportive of national or international perspective. They have developed a prototype global nuclear material management and control systems analysis capability, the Global Nuclear Material Control (GNMC) model. The GNMC model establishes the framework for evaluating the global production, disposition, and safeguards and security requirements for fissile nuclear material.

  12. Mater Academy Charter Middle School: Consistent Expectations

    ERIC Educational Resources Information Center

    Principal Leadership, 2010

    2010-01-01

    Mater Academy Charter Middle/High School is located in what was once a big box store in a commercial and industrial area of Hialeah Gardens, FL. The same energy that transformed a vacant store into a thriving campus for a grades 6-12 school is apparent in every classroom. Even the mayor of Hialeah Gardens credits the school with helping to…

  13. Flexible Electronics: An Epidermal Stimulation and Sensing Platform for Sensorimotor Prosthetic Control, Management of Lower Back Exertion, and Electrical Muscle Activation (Adv. Mater. 22/2016).

    PubMed

    Xu, Baoxing; Akhtar, Aadeel; Liu, Yuhao; Chen, Hang; Yeo, Woon-Hong; Park, Sung Ii; Boyce, Brandon; Kim, Hyunjin; Yu, Jiwoo; Lai, Hsin-Yen; Jung, Sungyoung; Zhou, Yuhao; Kim, Jeonghyun; Cho, Seongkyu; Huang, Yonggang; Bretl, Timothy; Rogers, John A

    2016-06-01

    The design of an ultrathin, conformal electronic device that integrates electrotactile stimulation with electromyography, temperature, and strain sensing in a single, simple platform is reported by J. A. Rogers and co-workers on page 4462. Demonstrated application possibilities include prosthetic control with sensory feedback, monitors, and stimulation signals related to lower back exertion, and electrical muscle stimulation with feedback control. PMID:27273442

  14. Chemical Sensors: Precisely Controlled Ultrathin Conjugated Polymer Films for Large Area Transparent Transistors and Highly Sensitive Chemical Sensors (Adv. Mater. 14/2016).

    PubMed

    Khim, Dongyoon; Ryu, Gi-Seong; Park, Won-Tae; Kim, Hyunchul; Lee, Myungwon; Noh, Yong-Young

    2016-04-01

    A precise control over the film thickness is a vital requirement for achievement of high performance in thin-film electronic devices. On page 2752, Y.-Y. Noh and co-workers develop an effective way to deposit a large-area and uniform ultrathin polymer film with a molecular-level precision via a simple wire-wound bar-coating method for high-performance organic transistors and gas sensors. PMID:27062168

  15. Nuclear Reactor Kinetics and Control.

    SciTech Connect

    JEFFERY,; LEWINS, D.

    2009-07-27

    Version 00 Dr. J.D. Lewins has now released the following legacy book for free distribution: Nuclear Reactor Kinetics and Control, Pergamon Press, London, 275 pages, 1978. 1. Introductory Review 2. Neutron and Precursor Equations 3. Elementary Solutions of the Kinetics Equations at Low Power 4. Linear Reactor Process Dynamics with Feedback 5. Power Reactor Control Systems 6. Fluctuations and Reactor Noise 7. Safety and Reliability 8. Non Linear Systems; Stability and Control 9. Analogue Computing Addendum: Jay Basken and Jeffery D. Lewins: Power Series Solution of the Reactor Kinetics Equations, Nuclear Science and Engineering: 122, 407-436 (1996) (authorized for distribution with the book: courtesy of the American Nuclear Society)

  16. Controlled Nuclear Fusion.

    ERIC Educational Resources Information Center

    Glasstone, Samuel

    This publication is one of a series of information booklets for the general public published by The United States Atomic Energy Commission. Among the topics discussed are: Importance of Fusion Energy; Conditions for Nuclear Fusion; Thermonuclear Reactions in Plasmas; Plasma Confinement by Magnetic Fields; Experiments With Plasmas; High-Temperature…

  17. Mater semper incertus est: who's your mummy?

    PubMed

    D'alton-Harrison, Rita

    2014-01-01

    In English law, the legal term for father has been given a broad definition but the definition of mother remains rooted in biology with the Roman law principle mater semper certa est (the mother is always certain) remaining the norm. However, motherhood may be acquired through giving birth to a child, by donation of gametes or by caring and nurturing a child so that the identity of the mother is no longer certain particularly in the case of surrogacy arrangements. While the law in the UK may automatically recognise the parental status of a commissioning father in a traditional surrogacy arrangement, the parental status of the commissioning mother is not automatically recognised in either a traditional or a gestational surrogacy arrangement. Thus the maxim mater est quam gestation demonstrat (meaning the mother is demonstrated by gestation) is also not approached consistently in the legal interpretation of parentage or motherhood in surrogacy as against other assisted reproduction methods. This raises questions about the extent to which motherhood should be affected by the method of reproduction and whether the sociological and philosophical concept of motherhood should, in the case of surrogacy, give rise to a new principle of 'mater semper incertus est' (the mother is uncertain). This article will argue that the time has come to move away from a legal definition of 'mother' that is based on biology to one that recognises the different forms of motherhood. PMID:24457376

  18. Nuclear reactor control apparatus

    DOEpatents

    Sridhar, Bettadapur N.

    1983-10-25

    Nuclear reactor safety rod release apparatus comprises a ring which carries detents normally positioned in an annular recess in outer side of the rod, the ring being held against the lower end of a drive shaft by magnetic force exerted by a solenoid carried by the drive shaft. When the solenoid is de-energized, the detent-carrying ring drops until the detents contact a cam surface associated with the lower end of the drive shaft, at which point the detents are cammed out of the recess in the safety rod to release the rod from the drive shaft. In preferred embodiments of the invention, an additional latch is provided to release a lower portion of a safety rod under conditions that may interfere with movement of the entire rod.

  19. Nuclear Reactor Kinetics and Control.

    Energy Science and Technology Software Center (ESTSC)

    2009-07-27

    Version 00 Dr. J.D. Lewins has now released the following legacy book for free distribution: Nuclear Reactor Kinetics and Control, Pergamon Press, London, 275 pages, 1978. 1. Introductory Review 2. Neutron and Precursor Equations 3. Elementary Solutions of the Kinetics Equations at Low Power 4. Linear Reactor Process Dynamics with Feedback 5. Power Reactor Control Systems 6. Fluctuations and Reactor Noise 7. Safety and Reliability 8. Non Linear Systems; Stability and Control 9. Analogue Computingmore » Addendum: Jay Basken and Jeffery D. Lewins: Power Series Solution of the Reactor Kinetics Equations, Nuclear Science and Engineering: 122, 407-436 (1996) (authorized for distribution with the book: courtesy of the American Nuclear Society)« less

  20. Nuclear reactor control room construction

    DOEpatents

    Lamuro, Robert C.; Orr, Richard

    1993-01-01

    A control room 10 for a nuclear plant is disclosed. In the control room, objects 12, 20, 22, 26, 30 are no less than four inches from walls 10.2. A ceiling 32 contains cooling fins 35 that extend downwards toward the floor from metal plates 34. A concrete slab 33 is poured over the plates. Studs 36 are welded to the plates and are encased in the concrete.

  1. Nuclear reactor control room construction

    DOEpatents

    Lamuro, R.C.; Orr, R.

    1993-11-16

    A control room for a nuclear plant is disclosed. In the control room, objects labelled 12, 20, 22, 26, 30 in the drawing are no less than four inches from walls labelled 10.2. A ceiling contains cooling fins that extend downwards toward the floor from metal plates. A concrete slab is poured over the plates. Studs are welded to the plates and are encased in the concrete. 6 figures.

  2. Advanced nuclear plant control complex

    DOEpatents

    Scarola, Kenneth; Jamison, David S.; Manazir, Richard M.; Rescorl, Robert L.; Harmon, Daryl L.

    1993-01-01

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  3. 21 CFR 882.5975 - Human dura mater.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Human dura mater. 882.5975 Section 882.5975 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Therapeutic Devices § 882.5975 Human dura mater....

  4. 21 CFR 882.5975 - Human dura mater.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Human dura mater. 882.5975 Section 882.5975 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Therapeutic Devices § 882.5975 Human dura mater....

  5. 21 CFR 882.5975 - Human dura mater.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Human dura mater. 882.5975 Section 882.5975 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Therapeutic Devices § 882.5975 Human dura mater....

  6. 21 CFR 882.5975 - Human dura mater.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Human dura mater. 882.5975 Section 882.5975 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Therapeutic Devices § 882.5975 Human dura mater....

  7. 21 CFR 882.5975 - Human dura mater.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Human dura mater. 882.5975 Section 882.5975 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Therapeutic Devices § 882.5975 Human dura mater....

  8. "Mater puerorum'. A medieval naming for an enigmatic children's disease.

    PubMed

    Kottek, S S

    1981-09-01

    The pediatric clinical entity called "Mater Puerorum' appears first in the latin translation of Rhazes' "Practica Puerorum' and in his "Continens'. His descriptions of the disease could give some likeness either to a diagnosis of night terrors, or of hyperpyretic convulsions, or of a slight form of epilepsy. Mater Puerorum is afterwards described by most pediatric authors till the Renaissance period without much originality. Rhazes being one of their main sources anyway. Mater Puerorum has been considered by Still and Radbill as a synonym for hysterical fits in children. Going back to the Arabic original naming: Ummu's Sibyan, we venture another etymology based on Babylonian-Judeo-Arabic demonology. The "Mother of the Children' could be the female demon Karina--or Lilith--which is said to come to plague the children at night. The naming Mater Puerorum could thus be ascribed to a folklore origin, rather than to hysteria. PMID:7023949

  9. The nuclear materials control technology briefing book

    SciTech Connect

    Hartwell, J.K.; Fernandez, S.J.

    1992-03-01

    As national and international interests in nuclear arms control and non-proliferation of nuclear weapons, intensify, it becomes ever more important that contributors be aware of the technologies available for the measurement and control of the nuclear materials important to nuclear weapons development. This briefing book presents concise, nontechnical summaries of various special nuclear material (SNM) and tritium production monitoring technologies applicable to the control of nuclear materials and their production. Since the International Atomic Energy Agency (IAEA) operates a multinational, on-site-inspector-based safeguards program in support of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), many (but not all) of the technologies reported in this document are in routine use or under development for IAEA safeguards.

  10. Reactivity control assembly for nuclear reactor

    DOEpatents

    Bollinger, Lawrence R.

    1984-01-01

    Reactivity control assembly for nuclear reactor comprises supports stacked above reactor core for holding control rods. Couplers associated with the supports and a vertically movable drive shaft have lugs at their lower ends for engagement with the supports.

  11. Nuclear electric propulsion reactor control systems status

    NASA Technical Reports Server (NTRS)

    Ferg, D. A.

    1973-01-01

    The thermionic reactor control system design studies conducted over the past several years for a nuclear electric propulsion system are described and summarized. The relevant reactor control system studies are discussed in qualitative terms, pointing out the significant advantages and disadvantages including the impact that the various control systems would have on the nuclear electric propulsion system design. A recommendation for the reference control system is made, and a program for future work leading to an engineering model is described.

  12. Electronic dura mater for long-term multimodal neural interfaces

    NASA Astrophysics Data System (ADS)

    Minev, Ivan R.; Musienko, Pavel; Hirsch, Arthur; Barraud, Quentin; Wenger, Nikolaus; Moraud, Eduardo Martin; Gandar, Jérôme; Capogrosso, Marco; Milekovic, Tomislav; Asboth, Léonie; Torres, Rafael Fajardo; Vachicouras, Nicolas; Liu, Qihan; Pavlova, Natalia; Duis, Simone; Larmagnac, Alexandre; Vörös, Janos; Micera, Silvestro; Suo, Zhigang; Courtine, Grégoire; Lacour, Stéphanie P.

    2015-01-01

    The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.

  13. Plasma Physics and Controlled Nuclear Fusion

    NASA Astrophysics Data System (ADS)

    Fisch, N. J.

    2010-01-01

    Already while making his famous contributions in uncontrolled nuclear fusion for wartime uses, Edward Teller contemplated how the abundant energy release through nuclear fusion might serve peacetime uses as well. His legacy in controlled nuclear fusion, and the associated physics of plasmas, spans both magnetic and inertial confinement approaches. His contributions in plasma physics, both the intellectual and the administrative, continue to impact the field.

  14. The Labour Market Effects of "Alma Mater": Evidence from Italy

    ERIC Educational Resources Information Center

    Brunello, Giorgio; Cappellari, Lorenzo

    2008-01-01

    We use data from a nationally representative survey of Italian graduates to study whether "Alma Mater" matters for employment and earnings 3 years after graduation. We find that the attended college matters, and that there are important college-related differences, both among and within regions of the country. These differences, however, do not…

  15. Neutron absorbing coating for nuclear criticality control

    DOEpatents

    Mizia, Ronald E.; Wright, Richard N.; Swank, William D.; Lister, Tedd E.; Pinhero, Patrick J.

    2007-10-23

    A neutron absorbing coating for use on a substrate, and which provides nuclear criticality control is described and which includes a nickel, chromium, molybdenum, and gadolinium alloy having less than about 5% boron, by weight.

  16. Dura mater is a potential source of Aβ seeds.

    PubMed

    Kovacs, Gabor G; Lutz, Mirjam I; Ricken, Gerda; Ströbel, Thomas; Höftberger, Romana; Preusser, Matthias; Regelsberger, Günther; Hönigschnabl, Selma; Reiner, Angelika; Fischer, Peter; Budka, Herbert; Hainfellner, Johannes A

    2016-06-01

    Deposition of amyloid-β (Aβ) in the brain parenchyma and vessels is one of the hallmarks of Alzheimer disease (AD). Recent observations of Aβ deposition in iatrogenic Creutzfeldt-Jakob disease (iCJD) after dural grafting or treatment with pituitary extracts raised concerns whether Aβ is capable of transmitting disease as seen in prion diseases by the disease-associated prion protein. To address this issue, we re-sampled and re-evaluated archival material, including the grafted dura mater of two cases with iCJD (28 and 33-years-old) without mutations in the AβPP, PSEN1 and PSEN2 genes, and carrying ε3/ε3 alleles of the APOE gene. In addition, we evaluated 84 dura mater samples obtained at autopsy (mean age 84.9 ± 0.3) in the community-based VITA study for the presence of Aβ deposition. We show that the dura mater may harbor Aβ deposits (13 %) in the form of cerebral amyloid angiopathy or amorphous aggregates. In both iCJD cases, the grafted dura mater had accumulated Aβ. The morphology and distribution pattern of cerebral Aβ deposition together with the lack of tau pathology distinguishes the Aβ proteinopathy in iCJD from AD, from that seen in young individuals without cognitive decline carrying one or two APOE4 alleles, and from that related to traumatic brain injury. Our novel findings of Aβ deposits in the dura mater, including the grafted dura, and the distinct cerebral Aβ distribution in iCJD support the seeding properties of Aβ. However, in contrast to prion diseases, our study suggests that such Aβ seeding is unable to reproduce the full clinicopathological phenotype of AD. PMID:27016065

  17. Variable flow control for a nuclear reactor control rod

    DOEpatents

    Carleton, Richard D.; Bhattacharyya, Ajay

    1978-01-01

    A variable flow control for a control rod assembly of a nuclear reactor that depends on turbulent friction though an annulus. The annulus is formed by a piston attached to the control rod drive shaft and a housing or sleeve fitted to the enclosure housing the control rod. As the nuclear fuel is burned up and the need exists for increased reactivity, the control rods are withdrawn, which increases the length of the annulus and decreases the rate of coolant flow through the control rod assembly.

  18. Strenghtened nuclear controls - maintaining the confidence for expanding nuclear cooperation

    SciTech Connect

    Burkart, A.R. )

    1992-01-01

    Events in the Gulf during 1990 and 1991 focused the world's attention on Iraq's challenge to the nuclear non-proliferation regime and the forceful response of the United Nations Security Council, the International Atomic Energy Agency, and the coalition partners. The paper will examine recent efforts to strengthen the regime in response to this and other challenges: the upgrading of the nuclear trigger lists, the extension of the control regime to dual-use exports, a renewed use by the IAEA of its special inspection authority under NPT safeguards agreements, a broad review of means to improve the application of safeguards, and a significant expansion of the number of NPT adherents. These efforts recognize the critical role that an effective control regime plays in providing the fundamental underpinning for cooperation in the peaceful uses of nuclear energy. The paper will also look as such events as the continued internationalization of the nuclear industry, the unprecedented efforts in meeting the safety needs of nuclear power in Eastern Europe, the dramatic growth in technical assistance through the IAEA and other important demonstrations that nuclear cooperation remains an important part of the balance struck in 1953 with the Atoms for Peace initiative.

  19. Autonomous Control of Nuclear Power Plants

    SciTech Connect

    Basher, H.

    2003-10-20

    A nuclear reactor is a complex system that requires highly sophisticated controllers to ensure that desired performance and safety can be achieved and maintained during its operations. Higher-demanding operational requirements such as reliability, lower environmental impacts, and improved performance under adverse conditions in nuclear power plants, coupled with the complexity and uncertainty of the models, necessitate the use of an increased level of autonomy in the control methods. In the opinion of many researchers, the tasks involved during nuclear reactor design and operation (e.g., design optimization, transient diagnosis, and core reload optimization) involve important human cognition and decisions that may be more easily achieved with intelligent methods such as expert systems, fuzzy logic, neural networks, and genetic algorithms. Many experts in the field of control systems share the idea that a higher degree of autonomy in control of complex systems such as nuclear plants is more easily achievable through the integration of conventional control systems and the intelligent components. Researchers have investigated the feasibility of the integration of fuzzy logic, neural networks, genetic algorithms, and expert systems with the conventional control methods to achieve higher degrees of autonomy in different aspects of reactor operations such as reactor startup, shutdown in emergency situations, fault detection and diagnosis, nuclear reactor alarm processing and diagnosis, and reactor load-following operations, to name a few. With the advancement of new technologies and computing power, it is feasible to automate most of the nuclear reactor control and operation, which will result in increased safety and economical benefits. This study surveys current status, practices, and recent advances made towards developing autonomous control systems for nuclear reactors.

  20. Nuclear propulsion control and health monitoring

    NASA Technical Reports Server (NTRS)

    Walter, P. B.; Edwards, R. M.

    1993-01-01

    An integrated control and health monitoring architecture is being developed for the Pratt & Whitney XNR2000 nuclear rocket. Current work includes further development of the dynamic simulation modeling and the identification and configuration of low level controllers to give desirable performance for the various operating modes and faulted conditions. Artificial intelligence and knowledge processing technologies need to be investigated and applied in the development of an intelligent supervisory controller module for this control architecture.

  1. Damper mechanism for nuclear reactor control elements

    DOEpatents

    Taft, William Elwood

    1976-01-01

    A damper mechanism which provides a nuclear reactor control element decelerating function at the end of the scram stroke. The total damping function is produced by the combination of two assemblies, which operate in sequence. First, a tapered dashram assembly decelerates the control element to a lower velocity, after which a spring hydraulic damper assembly takes over to complete the final damping.

  2. Fast-acting nuclear reactor control device

    DOEpatents

    Kotlyar, Oleg M.; West, Phillip B.

    1993-01-01

    A fast-acting nuclear reactor control device for moving and positioning a fety control rod to desired positions within the core of the reactor between a run position in which the safety control rod is outside the reactor core, and a shutdown position in which the rod is fully inserted in the reactor core. The device employs a hydraulic pump/motor, an electric gear motor, and solenoid valve to drive the safety control rod into the reactor core through the entire stroke of the safety control rod. An overrunning clutch allows the safety control rod to freely travel toward a safe position in the event of a partial drive system failure.

  3. Computers and quality control in nuclear medicine.

    PubMed

    Brookeman, V A

    1978-04-01

    The general topic of computers and nuclear medicine quality control may be approached from two main areas; controlling the quality of computerized studies, and computer applications in general nuclear medicine quality control. Overlap occurs when quality control of computer studies is performed by the computer itself. The uses of computers in record-keeping and in quality control of imaging instrumentation and in vitro studies, including radioimmunoassay, are discussed in this review. Aspects of quality control for computerized clinical cardiovascular, cerebral, and renal studies and emission computed tomography are reviewed, including consideration of difficulties and inaccuracies involved in the studies. Any automatic computer analysis program should incorporate adequate checks and error detection protocols and should illustrate results for verification. Current routine quality control procedures using the computer unfortunately are few. Quality control criteria are needed for camera/computer systems in high count rate clinical applications, and increasing emphasis should be aimed at quality control of those computerized dynamic and function studies in current clinical use. The computer has a valuable potential for nuclear medicine quality control. In vitro and computerized in vivo studies can be analyzed by readily available statistical programs, and variances can be monitored continuously. Computers can calibrate and monitor instrument performance regularly, and can handle managerial and clerical duties such as bookkeeping. PMID:684439

  4. Autonomous Control of Space Nuclear Reactors

    NASA Technical Reports Server (NTRS)

    Merk, John

    2013-01-01

    Nuclear reactors to support future robotic and manned missions impose new and innovative technological requirements for their control and protection instrumentation. Long-duration surface missions necessitate reliable autonomous operation, and manned missions impose added requirements for failsafe reactor protection. There is a need for an advanced instrumentation and control system for space-nuclear reactors that addresses both aspects of autonomous operation and safety. The Reactor Instrumentation and Control System (RICS) consists of two functionally independent systems: the Reactor Protection System (RPS) and the Supervision and Control System (SCS). Through these two systems, the RICS both supervises and controls a nuclear reactor during normal operational states, as well as monitors the operation of the reactor and, upon sensing a system anomaly, automatically takes the appropriate actions to prevent an unsafe or potentially unsafe condition from occurring. The RPS encompasses all electrical and mechanical devices and circuitry, from sensors to actuation device output terminals. The SCS contains a comprehensive data acquisition system to measure continuously different groups of variables consisting of primary measurement elements, transmitters, or conditioning modules. These reactor control variables can be categorized into two groups: those directly related to the behavior of the core (known as nuclear variables) and those related to secondary systems (known as process variables). Reliable closed-loop reactor control is achieved by processing the acquired variables and actuating the appropriate device drivers to maintain the reactor in a safe operating state. The SCS must prevent a deviation from the reactor nominal conditions by managing limitation functions in order to avoid RPS actions. The RICS has four identical redundancies that comply with physical separation, electrical isolation, and functional independence. This architecture complies with the

  5. Optogenetic control of nuclear protein export

    PubMed Central

    Niopek, Dominik; Wehler, Pierre; Roensch, Julia; Eils, Roland; Di Ventura, Barbara

    2016-01-01

    Active nucleocytoplasmic transport is a key mechanism underlying protein regulation in eukaryotes. While nuclear protein import can be controlled in space and time with a portfolio of optogenetic tools, protein export has not been tackled so far. Here we present a light-inducible nuclear export system (LEXY) based on a single, genetically encoded tag, which enables precise spatiotemporal control over the export of tagged proteins. A constitutively nuclear, chromatin-anchored LEXY variant expands the method towards light inhibition of endogenous protein export by sequestering cellular CRM1 receptors. We showcase the utility of LEXY for cell biology applications by regulating a synthetic repressor as well as human p53 transcriptional activity with light. LEXY is a powerful addition to the optogenetic toolbox, allowing various novel applications in synthetic and cell biology. PMID:26853913

  6. Reactivity control assembly for nuclear reactor. [LMFBR

    DOEpatents

    Bollinger, L.R.

    1982-03-17

    This invention, which resulted from a contact with the United States Department of Energy, relates to a control mechanism for a nuclear reactor and, more particularly, to an assembly for selectively shifting different numbers of reactivity modifying rods into and out of the core of a nuclear reactor. It has been proposed heretofore to control the reactivity of a breeder reactor by varying the depth of insertion of control rods (e.g., rods containing a fertile material such as ThO/sub 2/) in the core of the reactor, thereby varying the amount of neutron-thermalizing coolant and the amount of neutron-capturing material in the core. This invention relates to a mechanism which can advantageously be used in this type of reactor control system.

  7. Controlled Nuclear Fusion: Status and Outlook

    ERIC Educational Resources Information Center

    Rose, David J.

    1971-01-01

    Presents the history, current concerns and potential developments of nuclear fusion as a major energy source. Controlled fusion research is summarized, technological feasibility is discussed and environmental factors are examined. Relationships of alternative energy sources as well as energy utilization are considered. (JM)

  8. Advanced nuclear plant control room complex

    DOEpatents

    Scarola, Kenneth; Jamison, David S.; Manazir, Richard M.; Rescorl, Robert L.; Harmon, Daryl L.

    1993-01-01

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  9. Alarm system for a nuclear control complex

    DOEpatents

    Scarola, Kenneth; Jamison, David S.; Manazir, Richard M.; Rescorl, Robert L.; Harmon, Daryl L.

    1994-01-01

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  10. Console for a nuclear control complex

    DOEpatents

    Scarola, Kenneth; Jamison, David S.; Manazir, Richard M.; Rescorl, Robert L.; Harmon, Daryl L.

    1993-01-01

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  11. Nuclear engine flow reactivity shim control

    DOEpatents

    Walsh, J.M.

    1973-12-11

    A nuclear engine control system is provided which automatically compensates for reactor reactivity uncertainties at the start of life and reactivity losses due to core corrosion during the reactor life in gas-cooled reactors. The coolant gas flow is varied automatically by means of specially provided control apparatus so that the reactor control drums maintain a predetermined steady state position throughout the reactor life. This permits the reactor to be designed for a constant drum position and results in a desirable, relatively flat temperature profile across the core. (Official Gazette)

  12. Tailoring Mater-Bi properties by the use of a biowaste-derived additive

    NASA Astrophysics Data System (ADS)

    Cerruti, Pierfrancesco; Santagata, Gabriella; Gomez d'Ayala, Giovanna; Malinconico, Mario; Ambrogi, Veronica; Carfagna, Cosimo; Persico, Paola

    2010-06-01

    In this work, a polyphenol-containing extract from winery bio-waste (EP) has been used as additive to tailor Mater-Bi properties. EP was able to efficiently modulate both polymer processing and mechanical, thermal and biodegradation properties. EP decreased the melt viscosity, behaved as a Mater-Bi plasticizer and delayed the Mater-Bi crosslinking process occurring upon thermal aging. Finally, the biodisintegration rate of doped Mater-Bi decreased, thus indicating that EP interfered with the microbial digestion of the polymer films.

  13. Transmission electron microscope evidence of telocytes in canine dura mater.

    PubMed

    Xu, Ting; Lu, Shanshan; Zhang, Hongqi

    2016-01-01

    Telocytes (TCs) are a novel type of interstitial cells present in a wide variety of organs and tissues (www.telocytes.com). Telocytes are identified morphologically by a small cell body and specific long prolongations (telopodes) alternating thin segments (podomers) with dilations (podoms). The presence of TCs in rat meninges has been identified in previous research. We here present further evidence that TCs existed in canine dura mater, closed to capillary and surrounded by a great deal of collagen fibres under transmission electron microscope. PMID:26781033

  14. Measurement control administration for nuclear materials accountability

    SciTech Connect

    Rudy, C.R.

    1991-01-31

    In 1986 a measurement control program was instituted at Mound to ensure that measurement performance used for nuclear material accountability was properly monitored and documented. The organization and management of various aspects of the program are discussed. Accurate measurements are the basis of nuclear material accountability. The validity of the accountability values depends on the measurement results that are used to determine inventories, receipts, and shipments. With this measurement information, material balances are calculated to determine losses and gains of materials during a specific time period. Calculation of Inventory Differences (ID) are based on chemical or physical measurements of many items. The validity of each term is dependent on the component measurements. Thus, in Figure 1, the measured element weight of 17 g is dependent on the performance of the particular measurement system that was used. In this case, the measurement is performed using a passive gamma ray method with a calibration curve determined by measuring representative standards containing a range of special nuclear materials (Figure 2). One objective of a measurement control program is to monitor and verify the validity of the calibration curve (Figure 3). In 1986 Mound's Nuclear Materials Accountability (NMA) group instituted a formal measurement control program to ensure the validity of the numbers that comprise this equation and provide a measure of how well bulk materials can be controlled. Most measurements used for accountability are production measurements with their own quality assurance programs. In many cases a measurement control system is planned and maintained by the developers and operators of the particular measurement system with oversight by the management responsible for the results. 4 refs., 7 figs.

  15. Effects of sepsis on mast cells in rat dura mater: influence of L-NAME and VIP

    PubMed Central

    Tore, F; Reynier-Rebuffel, A M; Tuncel, N; Callebert, J; Aubineau, P

    2001-01-01

    The influence of lipopolysaccharide (LPS)-induced sepsis on the various mast cell phenotypes of rat dura mater were examined both by immunohistochemical and biochemical methods.Three different populations of mast cells were identified in control rats: connective tissue type mast cells (CTMC) which contain rat mast cell protease1 (RMCP1), histamine, serotonin and heparin, mucosal type mast cells (MMC) which contain RMCP2, histamine and serotonin, and intermediate type which contains both RMCP1 and RMCP2 and probably various proportions of amines and heparin.LPS (25 mg kg−1 i.p.) caused changes in the proportions of the various types of mast cells. The number of MMC and intermediate type mast cells significantly increased and the number of mast cells immunopositive for both heparin and serotonin significantly decreased. Biochemical analysis showed that the histamine concentration of dura increased while its serotonin concentration decreased.While vasoactive intestinal peptide (VIP) (25 ng kg−1 i.p.) appears to potentiate LPS effects on dura mater mast cells, non-selective inhibition of nitric oxide (NO) synthase by Ng-nitro-L-arginine methyl ester (L-NAME) (30 mg kg−1 i.p.) did not influence sepsis-induced mast cell changes.These findings suggest that mast cells of dura mater may play a role in brain protection during sepsis. PMID:11724741

  16. Nuclear power plant control room operator control and monitoring tasks

    SciTech Connect

    Bovell, C.R.; Beck, M.G.; Carter, R.J.

    1998-07-01

    Oak Ridge National Laboratory is conducting a research project the purpose of which is to develop the technical bases for regulatory review criteria for use in evaluating the safety implications of human factors associated with the use of artificial intelligence and expert systems, and with advanced instrumentation and control (I and C) systems in nuclear power plants (NPP). This report documents the results from Task 8 of that project. The primary objectives of the task was to identify the scope and type of control and monitoring tasks now performed by control-room operators. Another purpose was to address the types of controls and safety systems needed to operate the nuclear plant. The final objective of Task 8 was to identify and categorize the type of information and displays/indicators required to monitor the performance of the control and safety systems. This report also discusses state-of-the-art controls and advanced display devices which will be available for use in control-room retrofits and in control room of future plants. The fundamental types of control and monitoring tasks currently conducted by operators can be divided into four classifications: function monitoring tasks, control manipulation tasks, fault diagnostic tasks, and administrative tasks. There are three general types of controls used in today`s NPPs, switches, pushbuttons, and analog controllers. Plant I and C systems include components to achieve a number of safety-related functions: measuring critical plant parameters, controlling critical plant parameters within safety limits, and automatically actuating protective devices if safe limits are exceeded. The types of information monitored by the control-room operators consist of the following parameters: pressure, fluid flow and level, neutron flux, temperature, component status, water chemistry, electrical, and process and area radiation. The basic types of monitoring devices common to nearly all NPP control rooms include: analog meters

  17. Fission control system for nuclear reactor

    DOEpatents

    Conley, G.H.; Estes, G.P.

    Control system for nuclear reactor comprises a first set of reactivity modifying rods fixed in a reactor core with their upper ends stepped in height across the core, and a second set of reactivity modifying rods movable vertically within the reactor core and having their lower ends stepped to correspond with the stepped arrangement of the first set of rods, pairs of the rods of the first and second sets being in coaxial alignment.

  18. Control rod for a nuclear reactor

    DOEpatents

    Roman, Walter G.; Sutton, Jr., Harry G.

    1979-01-01

    A control rod assembly for a nuclear reactor is disclosed having a remotely disengageable coupling between the control rod and the control rod drive shaft. The coupling is actuated by first lowering then raising the drive shaft. The described motion causes axial repositioning of a pin in a grooved rotatable cylinder, each being attached to different parts of the drive shaft which are axially movable relative to each other. In one embodiment, the relative axial motion of the parts of the drive shaft is used either to couple or to uncouple the connection by forcing resilient members attached to the drive shaft into or out of shouldered engagement, respectively, with an indentation formed in the control rod.

  19. Fuzzy controllers in nuclear material accounting

    SciTech Connect

    Zardecki, A.

    1994-10-01

    Fuzzy controllers are applied to predicting and modeling a time series, with particular emphasis on anomaly detection in nuclear material inventory differences. As compared to neural networks, the fuzzy controllers can operate in real time; their learning process does not require many iterations to converge. For this reason fuzzy controllers are potentially useful in time series forecasting, where the authors want to detect and identify trends in real time. They describe an object-oriented implementation of the algorithm advanced by Wang and Mendel. Numerical results are presented both for inventory data and time series corresponding to chaotic situations, such as encountered in the context of strange attractors. In the latter case, the effects of noise on the predictive power of the fuzzy controller are explored.

  20. Nuclear modernization and arms control in NATO

    SciTech Connect

    Kanter, A.

    1988-12-01

    The INF Treaty and its aftermath have not simply returned NATO to a world without ground-launched cruise missiles (GLCMs), Pershing II, and the SS-20, but have crystallized and reinforced long-standing questions about the credibility of NATO's strategy of flexible response, the appropriate role of theater nuclear weapons in the future, and the prospects for continued U.S. leadership of the Alliance. These issues come together in a consideration of whether and how NATO should modernize its remaining nuclear forces. This Note analyzes different ways in which NATO can respond to the nuclear requirements that flow from its strategy. It considers how INF Treaty constraints and prospective START limits, as well as the special place and concerns of the Federal Republic of Germany (FRG), bear on the various possibilities. It also assesses the implications of different choices for Alliance cohesion, U.S. leadership of NATO, and extended deterrence. On the basis of that analysis, it describes an approach to NATO nuclear modernization and arms control.

  1. 10 CFR 74.51 - Nuclear material control and accounting for strategic special nuclear material.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Nuclear material control and accounting for strategic special nuclear material. 74.51 Section 74.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Formula Quantities of Strategic Special...

  2. 10 CFR 74.51 - Nuclear material control and accounting for strategic special nuclear material.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Nuclear material control and accounting for strategic special nuclear material. 74.51 Section 74.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Formula Quantities of Strategic Special...

  3. 10 CFR 74.51 - Nuclear material control and accounting for strategic special nuclear material.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Nuclear material control and accounting for strategic special nuclear material. 74.51 Section 74.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Formula Quantities of Strategic Special...

  4. 10 CFR 74.51 - Nuclear material control and accounting for strategic special nuclear material.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Nuclear material control and accounting for strategic special nuclear material. 74.51 Section 74.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Formula Quantities of Strategic Special...

  5. 10 CFR 74.51 - Nuclear material control and accounting for strategic special nuclear material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Nuclear material control and accounting for strategic special nuclear material. 74.51 Section 74.51 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Formula Quantities of Strategic Special...

  6. Controlling nuclear weapons: Democracy versus guardianship

    SciTech Connect

    Dahl, R.

    1985-01-01

    This is not a new plan for arms control but an inquiry as to whether democratic institutions can cope with the major problems of public policy today. Robert Dahl points out that decisions on nuclear weapons (or disposal of nuclear waste, reactor safety or industrial pollution, to cite a few examples) are too complex and technical for the average citizen; yet if they are turned over to an elite of experts or ''wise men'' or guardians, there is no guarantee that those men will have the moral and other qualities needed to serve the public good-delegated power in these circumstances tends to become alienated power. Dahl has a partial answer: make use of the new communications technology to raise level of public knowledge and understanding.

  7. Magnetic nuclear core restraint and control

    DOEpatents

    Cooper, Martin H.

    1978-01-01

    A lateral restraint and control system for a nuclear reactor core adaptable to provide an inherent decrease of core reactivity in response to abnormally high reactor coolant fluid temperatures. An electromagnet is associated with structure for radially compressing the core during normal reactor conditions. A portion of the structures forming a magnetic circuit are composed of ferromagnetic material having a curie temperature corresponding to a selected coolant fluid temperature. Upon a selected signal, or inherently upon a preselected rise in coolant temperature, the magnetic force is decreased a given amount sufficient to relieve the compression force so as to allow core radial expansion. The expanded core configuration provides a decreased reactivity, tending to shut down the nuclear reaction.

  8. Magnetic nuclear core restraint and control

    DOEpatents

    Cooper, Martin H.

    1979-01-01

    A lateral restraint and control system for a nuclear reactor core adaptable to provide an inherent decrease of core reactivity in response to abnormally high reactor coolant fluid temperatures. An electromagnet is associated with structure for radially compressing the core during normal reactor conditions. A portion of the structures forming a magnetic circuit are composed of ferromagnetic material having a curie temperature corresponding to a selected coolant fluid temperature. Upon a selected signal, or inherently upon a preselected rise in coolant temperature, the magnetic force is decreased a given amount sufficient to relieve the compression force so as to allow core radial expansion. The expanded core configuration provides a decreased reactivity, tending to shut down the nuclear reaction.

  9. Issues for Future Nuclear Arms Control

    NASA Astrophysics Data System (ADS)

    Davis, Jay

    2011-04-01

    Ratification of the New START treaty may open the door to a path of progressive negotiations that could lead to systematic reduction of the numbers of deployed and reserve nuclear weapons. Those negotiations will require more than merely resolving technical, operational and policy questions. Their success will also demand adding successively larger numbers of partners and the building of trust among parties who have not been involved in such agreements before. At some point, questions of conventional arms limitations and larger confidence building steps will inevitably arise. Jay Davis, who last year chaired an APS/POPA study of technology issues for future nuclear arms control agreements, will outline the path, opportunities, and obstacles that lie ahead. Davis was an UNSCOM inspector in Iraq after the First Gulf War and the first director of the Defense Threat Reduction Agency.

  10. Nuclear reactor shutdown control rod assembly

    DOEpatents

    Bilibin, Konstantin

    1988-01-01

    A temperature responsive, self-actuated nuclear reactor shutdown control rod assembly 10. The upper end 18 of a lower drive line 17 fits within the lower end of an upper drive line 12. The lower end (not shown) of the lower drive line 17 is connected to a neutron absorber. During normal temperature conditions the lower drive line 17 is supported by detent means 22,26. When an overtemperature condition occurs thermal actuation means 34 urges ring 26 upwardly sufficiently to allow balls 22 to move radially outwardly thereby allowing lower drive line 17 to move downwardly toward the core of the nuclear reactor resulting in automatic reduction of the reactor powder.

  11. MEANS FOR CONTROLLING A NUCLEAR REACTOR

    DOEpatents

    Wilson, V.C.; Overbeck, W.P.; Slotin, L.; Froman, D.K.

    1957-12-17

    This patent relates to nuclear reactors of the type using a solid neutron absorbing material as a means for controlling the reproduction ratio of the system and thereby the power output. Elongated rods of neutron absorbing material, such as boron steel for example, are adapted to be inserted and removed from the core of tae reactor by electronic motors and suitable drive means. The motors and drive means are controlled by means responsive to the neutron density, such as ionization chambers. The control system is designed to be responsive also to the rate of change in neutron density to automatically maintain the total power output at a substantially constant predetermined value. A safety rod means responsive to neutron density is also provided for keeping the power output below a predetermined maximum value at all times.

  12. Apparatus for controlling nuclear core debris

    DOEpatents

    Jones, Robert D.

    1978-01-01

    Nuclear reactor apparatus for containing, cooling, and dispersing reactor debris assumed to flow from the core area in the unlikely event of an accident causing core meltdown. The apparatus includes a plurality of horizontally disposed vertically spaced plates, having depressions to contain debris in controlled amounts, and a plurality of holes therein which provide natural circulation cooling and a path for debris to continue flowing downward to the plate beneath. The uppermost plates may also include generally vertical sections which form annular-like flow areas which assist the natural circulation cooling.

  13. Nuclear Technology Series. Course 33: Control Systems I.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  14. Nuclear Technology Series. Course 34: Control Systems II.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  15. 22 CFR 123.20 - Nuclear related controls.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Nuclear related controls. 123.20 Section 123.20... DEFENSE ARTICLES § 123.20 Nuclear related controls. (a) The provisions of this subchapter do not apply to... of Energy or the Nuclear Regulatory Commission pursuant to the Atomic Energy Act of 1954, as...

  16. 22 CFR 123.20 - Nuclear related controls.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Nuclear related controls. 123.20 Section 123.20... DEFENSE ARTICLES § 123.20 Nuclear related controls. (a) The provisions of this subchapter do not apply to... of Energy or the Nuclear Regulatory Commission pursuant to the Atomic Energy Act of 1954, as...

  17. Thrust Vector Control for Nuclear Thermal Rockets

    NASA Technical Reports Server (NTRS)

    Ensworth, Clinton B. F.

    2013-01-01

    Future space missions may use Nuclear Thermal Rocket (NTR) stages for human and cargo missions to Mars and other destinations. The vehicles are likely to require engine thrust vector control (TVC) to maintain desired flight trajectories. This paper explores requirements and concepts for TVC systems for representative NTR missions. Requirements for TVC systems were derived using 6 degree-of-freedom models of NTR vehicles. Various flight scenarios were evaluated to determine vehicle attitude control needs and to determine the applicability of TVC. Outputs from the models yielded key characteristics including engine gimbal angles, gimbal rates and gimbal actuator power. Additional factors such as engine thrust variability and engine thrust alignment errors were examined for impacts to gimbal requirements. Various technologies are surveyed for TVC systems for the NTR applications. A key factor in technology selection is the unique radiation environment present in NTR stages. Other considerations including mission duration and thermal environments influence the selection of optimal TVC technologies. Candidate technologies are compared to see which technologies, or combinations of technologies best fit the requirements for selected NTR missions. Representative TVC systems are proposed and key properties such as mass and power requirements are defined. The outputs from this effort can be used to refine NTR system sizing models, providing higher fidelity definition for TVC systems for future studies.

  18. Macrofouling control in nuclear power plants

    SciTech Connect

    Ekis, E.W. Jr.; Keoplin-Gall, S.M.; McCarthy, R.E.

    1991-11-01

    Macrofouling of cooling-water systems is one of the more significant and costly problems encountered in the nuclear power industry. Both marine and freshwater macroinvertebrates can be responsible for losses in plant availability because of plugged intakes and heat transfer equipment. There is a greater diversity of macrofouling organisms in marine waters than in fresh waters. Marine macrofouling organisms include barnacles, mollusks, bryozoans, and hydroids. Barnacles are crustaceans with feathery appendages, which allow them to attach to a variety of surfaces. They are a major cause of severe macrofouling because they can remain attached even after death. The major freshwater macrofouling organisms include the Asiatic Clam (Corbicula fluminea) and the newest freshwater macrofouler, the Zebra Mussel (Dreissena polymorpha). The introduction of the Zebra Mussel into the Great Lakes has created economic and ecological problems that will not easily be solved. The threat of intercontinental dispersal of the Zebra Mussel in America is serious. Research programs have been initiated around the country to develop control methods for this macrofouling problem. The various control methodologies can be classified in the following categories: biological, chemical, physical, and mechanical. Laboratory experiments were performed to evaluate the efficacy of Actibrom against mature Zebra Mussels.

  19. Experimental study on the mechanical interaction between silicon neural microprobes and rat dura mater during insertion.

    PubMed

    Fekete, Z; Németh, A; Márton, G; Ulbert, I; Pongrácz, A

    2015-02-01

    In vivo insertion experiments are essential to optimize novel neural implants. Our work focuses on the interaction between intact dura mater of rats and as-fabricated single-shaft silicon microprobes realized by deep reactive ion etching. Implantation parameters like penetration force and dimpling through intact dura mater were studied as a function of insertion speed, microprobe cross-section, tip angle and animal age. To reduce tissue resistance, we proposed a unique tip sharpening technique, which was also evaluated in in vivo insertion tests. By doubling the insertion speed (between 1.2 and 10.5 mm/min), an increase of 10-35% in penetration forces was measured. When decreasing the cross-section of the microprobes, penetration forces and dimpling was reduced by as much as 30-50% at constant insertion speeds. Force was noticed to gradually decrease by decreasing tip angles. Measured penetration forces through dura mater were reduced even down to 11±3 mN compared to unsharpened (49±13 mN) probes by utilizing our unique tip sharpening technique, which is very close to exerted penetration force in the case of retracted dura (5±1.5 mN). Our findings imply that age remarkably alters the elasticity of intact dura mater. The decreasing stiffness of dura mater results in a significant rise in penetration force and decrease in dimpling. Our work is the first in vivo comparative study on microelectrode penetration through intact and retracted dura mater. PMID:25631267

  20. 77 FR 28407 - Special Nuclear Material Control and Accounting Systems for Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... January 1998 (63 FR 2426; January 15, 1998), because the underlying basis standard, ANSI N15.8-1974... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Special Nuclear Material Control and Accounting Systems for Nuclear Power Plants AGENCY:...

  1. 78 FR 38739 - Special Nuclear Material Control and Accounting Systems for Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ... Information DG-5028, was published in the Federal Register on May 14, 2012 (77 FR 28407), for a 60-day public... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Special Nuclear Material Control and Accounting Systems for Nuclear Power Plants AGENCY:...

  2. Boron control system for a nuclear power plant

    SciTech Connect

    Brown, W.W.; Van der Schoot, M.R.

    1980-09-30

    Ion exchangers which reversibly store borate ions in a temperature dependent process are combined with evaporative boric acid recovery apparatus to provide a boron control system for controlling the reactivity of nuclear power plants. A plurality of ion exchangers are operated sequentially to provide varying amounts of boric acid to a nuclear reactor for load follow operations. Evaporative boric acid recovery apparatus is utilized for major changes in the boron concentration within the nuclear reactor.

  3. Control of spending on nuclear safety

    SciTech Connect

    Siddall, E.

    1980-07-01

    Nuclear safety is reviewed in relation to safety in the community as a whole. A method is proposed which points to an optimum expenditure on nuclear safety measures as opposed to the present open-ended situation. At this optimum point the cost of saving extra lives in the nuclear field is equal to the cost of saving extra lives in other activities in the community. The method requires that the present level of safety be estimated, and this is done by relating the work of Rasmussen, Farmer and Beattie; and the recent German study to the actual record of accidents. The analysis indicates that present expenditures on reactor safety are far in excess of the optimum. An even more striking conclusion is reached when the possible effect of the wealth-generated by the nuclear industry on the general safety of the community is considered. The application of the theme to the Pickering Nuclear Generating Station is developed.

  4. Border Safety: Quality Control at the Nuclear Envelope.

    PubMed

    Webster, Brant M; Lusk, C Patrick

    2016-01-01

    The unique biochemical identity of the nuclear envelope confers its capacity to establish a barrier that protects the nuclear compartment and directly contributes to nuclear function. Recent work uncovered quality control mechanisms employing the endosomal sorting complexes required for transport (ESCRT) machinery and a new arm of endoplasmic reticulum-associated protein degradation (ERAD) to counteract the unfolding, damage, or misassembly of nuclear envelope proteins and ensure the integrity of the nuclear envelope membranes. Moreover, cells have the capacity to recognize and triage defective nuclear pore complexes to prevent their inheritance and preserve the longevity of progeny. These mechanisms serve to highlight the diverse strategies used by cells to maintain nuclear compartmentalization; we suggest they mitigate the progression and severity of diseases associated with nuclear envelope malfunction such as the laminopathies. PMID:26437591

  5. 10 CFR 74.31 - Nuclear material control and accounting for special nuclear material of low strategic significance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Nuclear material control and accounting for special nuclear material of low strategic significance. 74.31 Section 74.31 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear Material of...

  6. 10 CFR 74.41 - Nuclear material control and accounting for special nuclear material of moderate strategic...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Nuclear material control and accounting for special nuclear material of moderate strategic significance. 74.41 Section 74.41 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear...

  7. 10 CFR 74.31 - Nuclear material control and accounting for special nuclear material of low strategic significance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Nuclear material control and accounting for special nuclear material of low strategic significance. 74.31 Section 74.31 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear Material of...

  8. 10 CFR 74.31 - Nuclear material control and accounting for special nuclear material of low strategic significance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Nuclear material control and accounting for special nuclear material of low strategic significance. 74.31 Section 74.31 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear Material of...

  9. 10 CFR 74.41 - Nuclear material control and accounting for special nuclear material of moderate strategic...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Nuclear material control and accounting for special nuclear material of moderate strategic significance. 74.41 Section 74.41 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear...

  10. 10 CFR 74.41 - Nuclear material control and accounting for special nuclear material of moderate strategic...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Nuclear material control and accounting for special nuclear material of moderate strategic significance. 74.41 Section 74.41 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear...

  11. 10 CFR 74.41 - Nuclear material control and accounting for special nuclear material of moderate strategic...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Nuclear material control and accounting for special nuclear material of moderate strategic significance. 74.41 Section 74.41 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear...

  12. 10 CFR 74.41 - Nuclear material control and accounting for special nuclear material of moderate strategic...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Nuclear material control and accounting for special nuclear material of moderate strategic significance. 74.41 Section 74.41 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear...

  13. 10 CFR 74.31 - Nuclear material control and accounting for special nuclear material of low strategic significance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Nuclear material control and accounting for special nuclear material of low strategic significance. 74.31 Section 74.31 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear Material of...

  14. 10 CFR 74.31 - Nuclear material control and accounting for special nuclear material of low strategic significance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Nuclear material control and accounting for special nuclear material of low strategic significance. 74.31 Section 74.31 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Special Nuclear Material of...

  15. U.S. national nuclear material control and accounting system

    SciTech Connect

    Taylor, S; Terentiev, V G

    1998-12-01

    Issues related to nuclear material control and accounting and illegal dealing in these materials were discussed at the April 19--20, 1996 Moscow summit meeting (G7 + Russia). The declaration from this meeting reaffirmed that governments are responsible for the safety of all nuclear materials in their possession and for the effectiveness of the national control and accounting system for these materials. The Russian delegation at this meeting stated that ''the creation of a nuclear materials accounting, control, and physical protection system has become a government priority''. Therefore, in order to create a government nuclear material control and accounting system for the Russian Federation, it is critical to study the structure, operating principles, and regulations supporting the control and accounting of nuclear materials in the national systems of nuclear powers. In particular, Russian specialists have a definite interest in learning about the National Nuclear Material Control and Accounting System of the US, which has been operating successfully as an automated system since 1968.

  16. Nuclear cost control focuses on refueling outages

    SciTech Connect

    Strauss, S.D.

    1995-12-01

    Extending operating cycles and shortening refueling outages are the mainstays of utility efforts to improve the economics of nuclear generation. Here are key management approaches that have contributed to recent successes. Improving operating efficiency remains the byword of nuclear power producers, as they intensify their drive to reduce operation and maintenance (O and M) costs and survive--even thrive--in a competitive environment. Because replacement-power and other costs can incur penalties of $0.5-million or more for each that a nuclear unit is inoperative--and almost $3-million/day, for one utility--refueling outages are an obvious focal point for such efforts, By the same token, the impact on the bottom line is greater and more dramatic here than for other cost-saving activities.

  17. MTR BASEMENT. GENERAL ELECTRIC CONTROL CONSOLE FOR AIRCRAFT NUCLEAR PROPULSION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MTR BASEMENT. GENERAL ELECTRIC CONTROL CONSOLE FOR AIRCRAFT NUCLEAR PROPULSION EXPERIMENT NO. 1. INL NEGATIVE NO. 6510. Unknown Photographer, 9/29/1959 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  18. Nuclear Forensic Science: Analysis of Nuclear Material Out of Regulatory Control

    NASA Astrophysics Data System (ADS)

    Kristo, Michael J.; Gaffney, Amy M.; Marks, Naomi; Knight, Kim; Cassata, William S.; Hutcheon, Ian D.

    2016-06-01

    Nuclear forensic science seeks to identify the origin of nuclear materials found outside regulatory control. It is increasingly recognized as an integral part of a robust nuclear security program. This review highlights areas of active, evolving research in nuclear forensics, with a focus on analytical techniques commonly employed in Earth and planetary sciences. Applications of nuclear forensics to uranium ore concentrates (UOCs) are discussed first. UOCs have become an attractive target for nuclear forensic researchers because of the richness in impurities compared to materials produced later in the fuel cycle. The development of chronometric methods for age dating nuclear materials is then discussed, with an emphasis on improvements in accuracy that have been gained from measurements of multiple radioisotopic systems. Finally, papers that report on casework are reviewed, to provide a window into current scientific practice.

  19. Addendum: Compliant electrostatic chuck based on hairy microstructure (2013 Smart Mater. Struct. 22 015019) and Electrostatic chuck consisting of polymeric electrostatic inductive fibers for handling of objects with rough surfaces (2013 Smart Mater. Struct. 22 095010)

    NASA Astrophysics Data System (ADS)

    Saito, Shigeki; Kikutani, Takeshi; Takahashi, Kunio; Takarada, Wataru; Soda, Fumiaki; Sawai, Kenji; Dhelika, Radon

    2014-07-01

    The recent papers Saito et al 2013 Smart Mater. Struct. 22 015019 and Dhelika et al 2013 Smart Mater. Struct. 22 095010 described studies of an electrostatic chuck that mimics the structure of gecko-like toes. Earlier work published by the authors and other researchers is cited to further illustrate the origin and motivation of the research.

  20. Proliferation of Nuclear Weapons: Opportunities for Control and Abolition

    PubMed Central

    Sidel, Victor W.; Levy, Barry S.

    2007-01-01

    Nuclear weapons pose a particularly destructive threat. Prevention of the proliferation and use of nuclear weapons is urgently important to public health. “Horizontal” proliferation refers to nation-states or nonstate entities that do not have, but are acquiring, nuclear weapons or developing the capability and materials for producing them. “Vertical” proliferation refers to nation-states that do possess nuclear weapons and are increasing their stockpiles of these weapons, improving the technical sophistication or reliability of their weapons, or developing new weapons. Because nation-states or other entities that wish to use or threaten to use nuclear weapons need methods for delivering those weapons, proliferation of delivery mechanisms must also be prevented. Controlling proliferation—and ultimately abolishing nuclear weapons—involves national governments, intergovernmental organizations, nongovernmental and professional organizations, and society at large. PMID:17666690

  1. Biomaterials. Electronic dura mater for long-term multimodal neural interfaces.

    PubMed

    Minev, Ivan R; Musienko, Pavel; Hirsch, Arthur; Barraud, Quentin; Wenger, Nikolaus; Moraud, Eduardo Martin; Gandar, Jérôme; Capogrosso, Marco; Milekovic, Tomislav; Asboth, Léonie; Torres, Rafael Fajardo; Vachicouras, Nicolas; Liu, Qihan; Pavlova, Natalia; Duis, Simone; Larmagnac, Alexandre; Vörös, Janos; Micera, Silvestro; Suo, Zhigang; Courtine, Grégoire; Lacour, Stéphanie P

    2015-01-01

    The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury. PMID:25574019

  2. [The surgical treatment of high myopia with dura mater. The results obtained long term (a clinical study)].

    PubMed

    Costin, D; Vancea, P P; Caraman, C; Burlea, M; Antohi, D; Popa, C; Stoian, R

    1990-01-01

    The paper presents the postoperative results obtained by performing scleroplasty with dura-mater in 127 progressive myopic eyes. The authors consider that the homologue dura-mater represents a high quality material to make scleral plasties. The evolution of myopia has ceased in over 60% of the cases. PMID:2100861

  3. Robust control technique for nuclear power plants

    SciTech Connect

    Murphy, G.V.; Bailey, J.M.

    1989-03-01

    This report summarizes the linear quadratic Guassian (LQG) design technique with loop transfer recovery (LQG/LTR) for design of control systems. The concepts of return ratio, return difference, inverse return difference, and singular values are summarized. The LQG/LTR design technique allows the synthesis of a robust control system. To illustrate the LQG/LTR technique, a linearized model of a simple process has been chosen. The process has three state variables, one input, and one output. Three control system design methods are compared: LQG, LQG/LTR, and a proportional plus integral controller (PI). 7 refs., 20 figs., 6 tabs.

  4. Nuclear reactor remote disconnect control rod coupling indicator

    DOEpatents

    Vuckovich, Michael

    1977-01-01

    A coupling indicator for use with nuclear reactor control rod assemblies which have remotely disengageable couplings between the control rod and the control rod drive shaft. The coupling indicator indicates whether the control rod and the control rod drive shaft are engaged or disengaged. A resistive network, utilizing magnetic reed switches, senses the position of the control rod drive mechanism lead screw and the control rod position indicating tube, and the relative position of these two elements with respect to each other is compared to determine whether the coupling is engaged or disengaged.

  5. CONTROL MEANS FOR A NUCLEAR REACTOR

    DOEpatents

    Teitel, R.J.

    1961-09-01

    A control means is described for a reactor which employs a liquid fuel consisting of a fissile isotope in a liquid bismuth solvent. The liquid fuel is contained in a plurality of tubular vessels. Control is effected by inserting plungers in the vessels to displace the liquid fuel and provide a critical or non- critical fuel configuration as desired.

  6. Nuclear reactivity control using laser induced polarization

    DOEpatents

    Bowman, Charles D.

    1991-01-01

    A control element for reactivity control of a fission source provides an atomic density of .sup.3 He in a control volume which is effective to control criticality as the .sup.3 He is spin-polarized. Spin-polarization of the .sup.3 He affects the cross section of the control volume for fission neutrons and hence, the reactivity. An irradiation source is directed within the .sup.3 He for spin-polarizing the .sup.3 He. An alkali-metal vapor may be included with the .sup.3 He where a laser spin-polarizes the alkali-metal atoms which in turn, spin-couple with .sup.3 He to spin-polarize the .sup.3 He atoms.

  7. Nuclear reactivity control using laser induced polarization

    DOEpatents

    Bowman, Charles D.

    1990-01-01

    A control element for reactivity control of a fission source provides an atomic density of .sup.3 He in a control volume which is effective to control criticality as the .sup.3 He is spin-polarized. Spin-polarization of the .sup.3 He affects the cross section of the control volume for fission neturons and hence, the reactivity. An irradiation source is directed within the .sup.3 He for spin-polarizing the .sup.3 He. An alkali-metal vapor may be included with the .sup.3 He where a laser spin-polarizes the alkali-metal atoms which in turn, spin-couple with .sup.3 He to spin-polarize the .sup.3 He atoms.

  8. St. Lucie nuclear plant's instrument setpoint control program

    SciTech Connect

    Woodruff, B.A. )

    1991-01-01

    In the past several years, instrument setpoint control has become an issue of significant utility focus and concern. Various nuclear industry initiatives have contributed to shaping the current environment. Florida Power and Light Company's St. Lucie nuclear plant maintains a proactive approach to implementing an instrument setpoint control program. St. Lucie's timely response to prevailing setpoint issues ensures that an effective setpoint program is the end result. Florida Power and Light (FP and L) initiated a setpoint control program at St. Lucie, a two-unit Combustion Engineering plant, in 1985. The plan's development was the result of obsolete equipment modifications, setpoint changes, and regulatory inquiries.

  9. CONTROL ROD FOR A NUCLEAR REACTOR AND METHOD OF PREPARATION

    DOEpatents

    Hausner, H.H.

    1958-12-30

    BS>An improved control rod is presented for a nuclear reactor. This control rod is comprised of a rare earth metal oxide or rare earth metal carbide such as gadolinium oxide or gadolinium carbide, uniformly distributed in a metal matrix having a low cross sectional area of absorption for thermal neutrons, such as aluminum, beryllium, and zirconium.

  10. 22 CFR 123.20 - Nuclear related controls.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... pursuant to these Acts. For Department of Commerce controls, see 15 CFR 742.3 and 744.2, administered...)), and 15 CFR 744.5, none of which are subject to the provisions of this subchapter. (c) A license for... the export control of the Department of Energy or the Nuclear Regulatory Commission pursuant to...

  11. Assessment of control rooms of nuclear power plants

    NASA Astrophysics Data System (ADS)

    Norros, L.; Ranta, J.; Wahlstroem, B.

    1983-05-01

    The NUREG 0700 recommendations were assessed for implementation in the control rooms of Finnish nuclear power plants. Direct conclusions drawn from the American situation are misleading, because of differences in, for example, procurement of instruments or personnel training. If the review is limited to control room details, the NRC program (checklist) is successful. It can also be used during planning to observe small discrepancies.

  12. Nuclear Arms Control, Nonproliferation, and Counterterrorism: Impacts on Public Health

    SciTech Connect

    Dreicer, Mona; Pregenzer, Arian

    2014-04-01

    Reducing the risks of nuclear war, limiting the spread of nuclear weapons and reducing global nuclear weapons stockpiles are key national and international security goals. They are pursued through a variety of international arms control, nonproliferation and counter-terrorism treaties and agreements. These legally binding and political commitments, together with the institutional infrastructure that supports them, work to establish global norms of behavior and have limited the spread of weapons of mass destruction. Beyond the primary security objectives, reducing the likelihood of the use of nuclear weapons, preventing environmental releases of radioactive material, increasing the availability of safe and secure nuclear technology for peaceful purposes, and providing scientific data relevant to predicting and managing the consequences of natural or human-caused disasters world-wide provide significant benefits to global public health.

  13. Nuclear arms control, nonproliferation, and counterterrorism: impacts on public health.

    PubMed

    Dreicer, Mona; Pregenzer, Arian

    2014-04-01

    Reducing the risks of nuclear war, limiting the spread of nuclear weapons, and reducing global nuclear weapons stockpiles are key national and international security goals. They are pursued through a variety of international arms control, nonproliferation, and counterterrorism treaties and agreements. These legally binding and political commitments, together with the institutional infrastructure that supports them, work to establish global norms of behavior and have limited the spread of weapons of mass destruction. Beyond the primary security objectives, reducing the likelihood of the use of nuclear weapons, preventing environmental releases of radioactive material, increasing the availability of safe and secure nuclear technology for peaceful purposes, and providing scientific data relevant to predicting and managing the consequences of natural or human-caused disasters worldwide provide significant benefits to global public health. PMID:24524501

  14. Nuclear Arms Control, Nonproliferation, and Counterterrorism: Impacts on Public Health

    PubMed Central

    Pregenzer, Arian

    2014-01-01

    Reducing the risks of nuclear war, limiting the spread of nuclear weapons, and reducing global nuclear weapons stockpiles are key national and international security goals. They are pursued through a variety of international arms control, nonproliferation, and counterterrorism treaties and agreements. These legally binding and political commitments, together with the institutional infrastructure that supports them, work to establish global norms of behavior and have limited the spread of weapons of mass destruction. Beyond the primary security objectives, reducing the likelihood of the use of nuclear weapons, preventing environmental releases of radioactive material, increasing the availability of safe and secure nuclear technology for peaceful purposes, and providing scientific data relevant to predicting and managing the consequences of natural or human-caused disasters worldwide provide significant benefits to global public health. PMID:24524501

  15. Nuclear reactor flow control method and apparatus

    DOEpatents

    Church, John P.

    1993-01-01

    Method and apparatus for improving coolant flow in a nuclear reactor during accident as well as nominal conditions. The reactor has a plurality of fuel elements in sleeves and a plenum above the fuel and through which the sleeves penetrate. Holes are provided in the sleeve so that coolant from the plenum can enter the sleeve and cool the fuel. The number and size of the holes are varied from sleeve to sleeve with the number and size of holes being greater for sleeves toward the center of the core and less for sleeves toward the periphery of the core. Preferably the holes are all the same diameter and arranged in rows and columns, the rows starting from the bottom of every sleeve and fewer rows in peripheral sleeves and more rows in the central sleeves.

  16. Nuclear reactor flow control method and apparatus

    DOEpatents

    Church, J.P.

    1993-03-30

    Method and apparatus for improving coolant flow in a nuclear reactor during accident as well as nominal conditions. The reactor has a plurality of fuel elements in sleeves and a plenum above the fuel and through which the sleeves penetrate. Holes are provided in the sleeve so that coolant from the plenum can enter the sleeve and cool the fuel. The number and size of the holes are varied from sleeve to sleeve with the number and size of holes being greater for sleeves toward the center of the core and less for sleeves toward the periphery of the core. Preferably the holes are all the same diameter and arranged in rows and columns, the rows starting from the bottom of every sleeve and fewer rows in peripheral sleeves and more rows in the central sleeves.

  17. Geochemical Controls on Nuclear Magnetic Resonance Measurements

    SciTech Connect

    Knight, Rosemary; Prasad, Manika; Keating, Kristina

    2003-11-11

    OAK-B135 Our research objectives are to determine, through an extensive set of laboratory experiments, the effect of the specific mineralogic form of iron and the effect of the distribution of iron on proton nuclear magnetic resonance (NMR) relaxation mechanisms. In the first nine months of this project, we have refined the experimental procedures to be used in the acquisition of the laboratory NMR data; have ordered, and conducted preliminary measurements on, the sand samples to be used in the experimental work; and have revised and completed the theoretical model to use in this project. Over the next year, our focus will be on completing the first phase of the experimental work where the form and distribution of the iron in the sands in varied.

  18. 76 FR 36993 - Medical Devices; Neurological Devices; Clarification of Classification for Human Dura Mater...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... CFR Part 882 Medical devices, Neurological devices. Therefore, under the Federal Food, Drug, and... Devices; Neurological Devices; Clarification of Classification for Human Dura Mater; Technical Amendment...). In the Federal Register of November 24, 2004 (69 FR 68612), FDA published a final rule...

  19. Interaction of micron and nano-sized particles with cells of the dura mater

    PubMed Central

    Papageorgiou, Iraklis; Marsh, Rainy; Tipper, Joanne L; Hall, Richard M; Fisher, John; Ingham, Eileen

    2014-01-01

    Intervertebral total disc replacements (TDR) are used in the treatment of degenerative spinal disc disease. There are, however, concerns that they may be subject to long-term failure due to wear. The adverse effects of TDR wear have the potential to manifest in the dura mater and surrounding tissues. The aim of this study was to investigate the physiological structure of the dura mater, isolate the resident dural epithelial and stromal cells and analyse the capacity of these cells to internalise model polymer particles. The porcine dura mater was a collagen-rich structure encompassing regularly arranged fibroblastic cells within an outermost epithelial cell layer. The isolated dural epithelial cells had endothelial cell characteristics (positive for von Willebrand factor, CD31, E-cadherin and desmoplakin) and barrier functionality whereas the fibroblastic cells were positive for collagen I and III, tenascin and actin. The capacity of the dural cells to take up model particles was dependent on particle size. Nanometer sized particles readily penetrated both types of cells. However, dural fibroblasts engulfed micron-sized particles at a much higher rate than dural epithelial cells. The study suggested that dural epithelial cells may offer some barrier to the penetration of micron-sized particles but not nanometer sized particles. © 2014 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1496–1505, 2014. PMID:24604838

  20. Modern control technology for improved nuclear reactor performance

    SciTech Connect

    Oakes, L.C.

    1986-12-01

    One of the main complaints leveled at reactor control systems by utility spokesmen is complexity. One only has to look inside a power reactor control room to appreciate this viewpoint. The high reliability and versatility of modern microprocessors makes possible distributed control systems with only performance data and abnormal conditions being relayed to the control room. In a sense, this emulates the human-body control system where routine repetitive actions are handled in an involuntary manner. The significance of expert systems to the nuclear reactor control and safety systems is their ability to capture human and other expertise and make it available, upon demand, and under almost all circumstances. Thus, human problem-solving skills acquired by the learning process over a long period of time can be captured and employed with the reliability inherent in computers. This is especially important in nuclear plants when human operators are burdened by stress and emotional factors that have a dramatic effect on performance level.

  1. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.12 Prohibitions on identifying...

  2. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.12 Prohibitions on identifying...

  3. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.11 Information exempt from...

  4. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.11 Information exempt from...

  5. SPRING DRIVEN ACTUATING MECHANISM FOR NUCLEAR REACTOR CONTROL

    DOEpatents

    Bevilacqua, F.; Uecker, D.F.; Groh, E.F.

    1962-01-23

    l962. rod in a nuclear reactor to shut it down. The control rod or an extension thereof is wound on a drum as it is withdrawn from the reactor. When an emergency occurs requiring the reactor to be shut down, the drum is released so as to be free to rotate, and the tendency of the control rod or its extension coiled on the drum to straighten itself is used for quickly returning the control rod to the reactor. (AEC)

  6. Identification of process controls for nuclear explosive operations

    SciTech Connect

    Fischer, S.R.; Konkel, H.; Houghton, K.; Wilson, M.

    1998-12-01

    Nuclear explosive assembly/disassembly operations that are carried out under United States Department of Energy (DOE) purview are characterized by activities that primarily involve manual tasks. These process activities are governed by procedural and administrative controls that traditionally have been developed without a formal link to process hazards. This work, which was based on hazard assessment (HA) activities conducted as part of the W69 Integrated Safety Process (ISP), specifies an approach to identifying formal safety controls for controlling (i.e., preventing or mitigating) hazards associated with nuclear explosive operations. Safety analysis methods are used to identify controls, which then are integrated into a safety management framework to provide assurance to the DOE that hazardous activities are managed properly. As a result of the work on the W69 ISP dismantlement effort, the authors have developed an approach to identify controls and safety measures to improve the safety of nuclear explosive operations. The methodology developed for the W69 dismantlement effort is being adapted to the W76 ISP effort. Considerable work is still ongoing to address issues such as the adequacy or effectiveness of controls. DOE nuclear explosive safety orders and some historical insights are discussed briefly in this paper. The safety measure identification methodology developed as part of the W69 ISP dismantlement process then is summarized.

  7. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Unclassified Controlled Nuclear Information markings on...) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Review of a Document or Material for Unclassified Controlled Nuclear Information § 1017.16 Unclassified Controlled Nuclear Information markings...

  8. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Unclassified Controlled Nuclear Information markings on...) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Review of a Document or Material for Unclassified Controlled Nuclear Information § 1017.16 Unclassified Controlled Nuclear Information markings...

  9. Design of robust level control system of nuclear steam generator

    NASA Astrophysics Data System (ADS)

    Lee, Y. J.; Na, M. G.

    2007-12-01

    The nuclear steam generator feedwater control system is designed by the robust control methods. The design is divided into two steps. First, the feedwater controller in the feedwater station is designed by H ∞ and MWS methods. Then the controller located on the feedback loop is designed both by classical PID and by robust technique. It is found that the feedback controller of simple PID whose coefficients vary with the power is proper for the system performance. The simulations show that the hybrid system of H ∞ and PID has a good performance with proper stability margins.

  10. Dual annular rotating "windowed" nuclear reflector reactor control system

    DOEpatents

    Jacox, Michael G.; Drexler, Robert L.; Hunt, Robert N. M.; Lake, James A.

    1994-01-01

    A nuclear reactor control system is provided in a nuclear reactor having a core operating in the fast neutron energy spectrum where criticality control is achieved by neutron leakage. The control system includes dual annular, rotatable reflector rings. There are two reflector rings: an inner reflector ring and an outer reflector ring. The reflectors are concentrically assembled, surround the reactor core, and each reflector ring includes a plurality of openings. The openings in each ring are capable of being aligned or non-aligned with each other. Independent driving means for each of the annular reflector rings is provided so that reactor criticality can be initiated and controlled by rotation of either reflector ring such that the extent of alignment of the openings in each ring controls the reflection of neutrons from the core.

  11. Temperature controls nuclear import of Tam3 transposase in Antirrhinum.

    PubMed

    Fujino, Kaien; Hashida, Shin-Nosuke; Ogawa, Takashi; Natsume, Tomoko; Uchiyama, Takako; Mikami, Tetsuo; Kishima, Yuji

    2011-01-01

    It has been proposed that environmental stimuli can activate transposable elements (TEs), whereas few substantial mechanisms have been shown so far. The class-II element Tam3 from Antirrhinum majus exhibits a unique property of low-temperature-dependent transposition (LTDT). LTDT has proved invaluable in developing the gene isolation technologies that have underpinned much of modern plant developmental biology. Here, we reveal that LTDT involves differential subcellular localization of the Tam3 transposase (TPase) in cells grown at low (15°C) and high (25°C) temperatures. The mechanism is associated with the nuclear import of Tam3 TPase in Antirrhinum cells. At high temperature, the nuclear import of Tam3 TPase is severely restricted in Antirrhinum cells, whereas at low temperature, the nuclear localization of Tam3 TPase is observed in about 20% of the cells. However, in tobacco BY-2 and Allium cepa (onion) cells, Tam3 TPase is transported into most nuclei. In addition to three nuclear localization signals (NLSs), the Tam3 TPase is equipped with a nuclear localization inhibitory domain (NLID), which functions to abolish nuclear import of the TPase at high temperature in Antirrhinum. NLID in Tam3 TPase is considered to interact with Antirrhinum-specific factor(s). The host-specific regulation of the nuclear localization of transposase represents a new repertoire controlling class-II TEs. PMID:21175897

  12. Nuclear Arms Control, Nonproliferation, and Counterterrorism: Impacts on Public Health

    DOE PAGESBeta

    Dreicer, Mona; Pregenzer, Arian

    2014-04-01

    Reducing the risks of nuclear war, limiting the spread of nuclear weapons and reducing global nuclear weapons stockpiles are key national and international security goals. They are pursued through a variety of international arms control, nonproliferation and counter-terrorism treaties and agreements. These legally binding and political commitments, together with the institutional infrastructure that supports them, work to establish global norms of behavior and have limited the spread of weapons of mass destruction. Beyond the primary security objectives, reducing the likelihood of the use of nuclear weapons, preventing environmental releases of radioactive material, increasing the availability of safe and secure nuclearmore » technology for peaceful purposes, and providing scientific data relevant to predicting and managing the consequences of natural or human-caused disasters world-wide provide significant benefits to global public health.« less

  13. Nuclear Instrumentation and Control Cyber Testbed Considerations – Lessons Learned

    SciTech Connect

    Jonathan Gray; Robert Anderson; Julio G. Rodriguez; Cheol-Kwon Lee

    2014-08-01

    Abstract: Identifying and understanding digital instrumentation and control (I&C) cyber vulnerabilities within nuclear power plants and other nuclear facilities, is critical if nation states desire to operate nuclear facilities safely, reliably, and securely. In order to demonstrate objective evidence that cyber vulnerabilities have been adequately identified and mitigated, a testbed representing a facility’s critical nuclear equipment must be replicated. Idaho National Laboratory (INL) has built and operated similar testbeds for common critical infrastructure I&C for over ten years. This experience developing, operating, and maintaining an I&C testbed in support of research identifying cyber vulnerabilities has led the Korean Atomic Energy Research Institute of the Republic of Korea to solicit the experiences of INL to help mitigate problems early in the design, development, operation, and maintenance of a similar testbed. The following information will discuss I&C testbed lessons learned and the impact of these experiences to KAERI.

  14. Nuclear Material Control and Accountability System Effectiveness Tool (MSET)

    SciTech Connect

    Powell, Danny H; Elwood Jr, Robert H; Roche, Charles T; Campbell, Billy J; Hammond, Glenn A; Meppen, Bruce W; Brown, Richard F

    2011-01-01

    A nuclear material control and accountability (MC&A) system effectiveness tool (MSET) has been developed in the United States for use in evaluating material protection, control, and accountability (MPC&A) systems in nuclear facilities. The project was commissioned by the National Nuclear Security Administration's Office of International Material Protection and Cooperation. MSET was developed by personnel with experience spanning more than six decades in both the U.S. and international nuclear programs and with experience in probabilistic risk assessment (PRA) in the nuclear power industry. MSET offers significant potential benefits for improving nuclear safeguards and security in any nation with a nuclear program. MSET provides a design basis for developing an MC&A system at a nuclear facility that functions to protect against insider theft or diversion of nuclear materials. MSET analyzes the system and identifies several risk importance factors that show where sustainability is essential for optimal performance and where performance degradation has the greatest impact on total system risk. MSET contains five major components: (1) A functional model that shows how to design, build, implement, and operate a robust nuclear MC&A system (2) A fault tree of the operating MC&A system that adapts PRA methodology to analyze system effectiveness and give a relative risk of failure assessment of the system (3) A questionnaire used to document the facility's current MPC&A system (provides data to evaluate the quality of the system and the level of performance of each basic task performed throughout the material balance area [MBA]) (4) A formal process of applying expert judgment to convert the facility questionnaire data into numeric values representing the performance level of each basic event for use in the fault tree risk assessment calculations (5) PRA software that performs the fault tree risk assessment calculations and produces risk importance factor reports on the

  15. Kinetic advantage of controlled intermediate nuclear fusion

    SciTech Connect

    Guo Xiaoming

    2012-09-26

    The dominated process of controlled fusion is to let nuclei gain enough kinetic energy to overcome Coulomb barrier. As a result, a fusion scheme can consider two factors in its design: to increase kinetic energy of nuclei and to alter the Coulomb barrier. Cold Fusion and Hot fusion are all one-factor schemes while Intermediate Fusion is a twofactors scheme. This made CINF kinetically superior. Cold Fusion reduces deuteron-deuteron distance, addressing Coulomb barrier, and Hot Fusion heat up plasma into extreme high temperature, addressing kinetic energy. Without enough kinetic energy made Cold Fusion skeptical. Extreme high temperature made Hot Fusion very difficult to engineer. Because CIFN addresses both factors, CIFN is a more promising technique to be industrialized.

  16. Kinetic advantage of controlled intermediate nuclear fusion

    NASA Astrophysics Data System (ADS)

    Guo, Xiaoming

    2012-09-01

    The dominated process of controlled fusion is to let nuclei gain enough kinetic energy to overcome Coulomb barrier. As a result, a fusion scheme can consider two factors in its design: to increase kinetic energy of nuclei and to alter the Coulomb barrier. Cold Fusion and Hot fusion are all one-factor schemes while Intermediate Fusion is a twofactors scheme. This made CINF kinetically superior. Cold Fusion reduces deuteron-deuteron distance, addressing Coulomb barrier, and Hot Fusion heat up plasma into extreme high temperature, addressing kinetic energy. Without enough kinetic energy made Cold Fusion skeptical. Extreme high temperature made Hot Fusion very difficult to engineer. Because CIFN addresses both factors, CIFN is a more promising technique to be industrialized.

  17. Next Generation Nuclear Plant Resilient Control System Functional Analysis

    SciTech Connect

    Lynne M. Stevens

    2010-07-01

    Control Systems and their associated instrumentation must meet reliability, availability, maintainability, and resiliency criteria in order for high temperature gas-cooled reactors (HTGRs) to be economically competitive. Research, perhaps requiring several years, may be needed to develop control systems to support plant availability and resiliency. This report functionally analyzes the gaps between traditional and resilient control systems as applicable to HTGRs, which includes the Next Generation Nuclear Plant; defines resilient controls; assesses the current state of both traditional and resilient control systems; and documents the functional gaps existing between these two controls approaches as applicable to HTGRs. This report supports the development of an overall strategy for applying resilient controls to HTGRs by showing that control systems with adequate levels of resilience perform at higher levels, respond more quickly to disturbances, increase operational efficiency, and increase public protection.

  18. METHOD AND APPARATUS FOR CONTROL OF A NUCLEAR REACTOR

    DOEpatents

    Cawley, W.E.

    1962-12-11

    A method and apparatus are described for controlling an overmoderated nuclear reactor containing columns of fuel elements aligned in a plurality of coolant tubes in a stream of coolant water. The invention includes means for adjusting the distance between halves of the fuel element column to vary the relative proportion of fuel and moderator at the center of the reactor. (AEC)

  19. CIA sheds new light on nuclear control in CIS

    SciTech Connect

    Lockwood, D.

    1993-03-01

    In a wide-ranging presentation to the Senate Governmental Affairs Committee February 24, 1993, newly installed CIA director James Woolsey and one of his senior aides provided a great deal of new information on nuclear weapons issues and how they are controlled in the former USSR. The main topics covered in the briefing are briefly discussed.

  20. Method of controlling crystallite size in nuclear-reactor fuels

    DOEpatents

    Lloyd, Milton H.; Collins, Jack L.; Shell, Sam E.

    1985-01-01

    Improved spherules for making enhanced forms of nuclear-reactor fuels are prepared by internal gelation procedures within a sol-gel operation and are accomplished by first boiling the concentrated HMTA-urea feed solution before engaging in the spherule-forming operation thereby effectively controlling crystallite size in the product spherules.

  1. Method of controlling crystallite size in nuclear-reactor fuels

    DOEpatents

    Lloyd, M.H.; Collins, J.L.; Shell, S.E.

    Improved spherules for making enhanced forms of nuclear-reactor fuels are prepared by internal gelation procedures within a sol-gel operation and are accomplished by first boiling the concentrated HMTA-urea feed solution before engaging in the spherule-forming operation thereby effectively controlling crystallite size in the product spherules.

  2. Automatic coolant flow control device for a nuclear reactor assembly

    DOEpatents

    Hutter, E.

    1984-01-27

    A device which controls coolant flow through a nuclear reactor assembly comprises a baffle means at the exit end of said assembly having a plurality of orifices, and a bimetallic member in operative relation to the baffle means such that at increased temperatures said bimetallic member deforms to unblock some of said orifices and allow increased coolant flow therethrough.

  3. Indicator system for advanced nuclear plant control complex

    DOEpatents

    Scarola, Kenneth; Jamison, David S.; Manazir, Richard M.; Rescorl, Robert L.; Harmon, Daryl L.

    1993-01-01

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  4. Quantum control of hybrid nuclear-electronic qubits.

    PubMed

    Morley, Gavin W; Lueders, Petra; Mohammady, M Hamed; Balian, Setrak J; Aeppli, Gabriel; Kay, Christopher W M; Witzel, Wayne M; Jeschke, Gunnar; Monteiro, Tania S

    2013-02-01

    Pulsed magnetic resonance allows the quantum state of electronic and nuclear spins to be controlled on the timescale of nanoseconds and microseconds respectively. The time required to flip dilute spins is orders of magnitude shorter than their coherence times, leading to several schemes for quantum information processing with spin qubits. Instead, we investigate 'hybrid nuclear-electronic' qubits consisting of near 50:50 superpositions of the electronic and nuclear spin states. Using bismuth-doped silicon, we demonstrate quantum control over these states in 32 ns, which is orders of magnitude faster than previous experiments using pure nuclear states. The coherence times of up to 4 ms are five orders of magnitude longer than the manipulation times, and are limited only by naturally occurring (29)Si nuclear spin impurities. We find a quantitative agreement between our experiments and an analytical theory for the resonance positions, as well as their relative intensities and Rabi oscillation frequencies. These results bring spins in a solid material a step closer to research on ion-trap qubits. PMID:23202370

  5. Nuclear nonproliferation, controls and US policy. Study report

    SciTech Connect

    Sasser, R.E.

    1993-03-17

    The world has lived under a nuclear threat since the US used nuclear weapons in World War II. After the war, superpowers evolved that provided nuclear umbrellas to their alliances. The recent decline and breakup of the USSR was hailed by many as the notice that nuclear weapons could be greatly reduced and that the entire world would be a safer place. What has evolved, unfortunately, is a still dangerous and complex world where nations are scrambling for sovereignty, power and status with continued emphasis on nuclear weapons. The US is deeply involved in developing nonproliferation policy to encompass this new environment of a changed world structure and a new balance of power. This paper examines this problem in depth starting with the sheer magnitude of the problem and then delving into each of the more prominent nonproliferation controls measures. These measures are examined for advantages, disadvantages and applicability to US policy. The Iraq pursuit of nuclear weapons and the UN and US response and actions are examined as a case study to determine lessons learned for US policy. Finally, existing US policy is examined to allow suggestion of policy changes based on the paper research.

  6. Instrumentation and control upgrade plan for Browns Ferry nuclear plant

    SciTech Connect

    Belew, M.R.; Langley, D.T. ); Torok, R.C.; Wilkinson, C.D. ); Stanley, L. )

    1992-01-01

    A comprehensive upgrade of the instrumentation and control (I C) systems at a power plant represents a formidable project for any utility. For a nuclear plant, the extra safety and reliability requirements along with regulatory constraints add further complications and cost. The need for the upgrade must, therefore, be very compelling, and the process must be well planned from the start. This paper describes the steps taken to initiate the I C upgrade process for Tennessee Valley Authority's (TVA's) Browns Ferry 2 nuclear plant. It explains the impetus for the upgrade, the expected benefits, and the process by which system upgrades will be selected and implemented.

  7. COMMERCIAL UTILITY PERSPECTIVES ON NUCLEAR POWER PLANT CONTROL ROOM MODERNIZATION

    SciTech Connect

    Jeffrey C. Joe; Ronald L. Boring; Julius J. Persensky

    2012-07-01

    Commercial nuclear power plants (NPPs) in the United States need to modernize their main control rooms (MCR). Many NPPs have done partial upgrades with some success and with some challenges. The Department of Energy’s (DOE) Light Water Reactor Sustainability (LWRS) Program, and in particular the Advanced Instrumentation and Controls (I&C) and Information Systems Technologies Research and Development (R&D) Pathway within LWRS, is designed to assist commercial nuclear power industry with their MCR modernization efforts. As part of this framework, a survey was issued to utility representatives of the LWRS Program Advanced Instrumentation, Information, and Control Systems/Technologies (II&C) Utility Working Group to obtain their views on a range of issues related to MCR modernization, including: drivers, barriers, and technology options, and the effects these aspects will have on concepts of operations, modernization strategies, and staffing. This paper summarizes the key survey results and discusses their implications.

  8. Effects of Radiation on Spinal Dura Mater and Surrounding Tissue in Mice

    PubMed Central

    Yokogawa, Noriaki; Murakami, Hideki; Demura, Satoru; Kato, Satoshi; Yoshioka, Katsuhito; Yamamoto, Miyuki; Iseki, Shoichi; Tsuchiya, Hiroyuki

    2015-01-01

    Purpose Spinal surgery in a previously irradiated field carries increased risk of perioperative complications, such as delayed wound healing or wound infection. In addition, adhesion around the dura mater is often observed clinically. Therefore, similar to radiation-induced fibrosis—a major late-stage radiation injury in other tissue—epidural fibrosis is anticipated to occur after spinal radiation. In this study, we performed histopathologic assessment of postirradiation changes in the spinal dura mater and peridural tissue in mice. Materials and Methods The thoracolumbar transition of ddY mice was irradiated with a single dose of 10 or 20 Gy. After resection of the irradiated spine, occurrence of epidural fibrosis and expression of transforming growth factor beta 1 in the spinal dura mater were evaluated. In addition, microstructures in the spinal dura mater and peridural tissue were assessed using an electron microscope. Results In the 20-Gy irradiated mice, epidural fibrosis first occurred around 12 weeks postirradiation, and was observed in all cases from 16 weeks postirradiation. In contrast, epidural fibrosis was not observed in the nonirradiated mice. Compared with the nonirradiated mice, the 10- and 20-Gy irradiated mice had significantly more overexpression of transforming growth factor beta 1 at 1 week postirradiation and in the late stages after irradiation. In microstructural assessment, the arachnoid barrier cell layer was thinned at 12 and 24 weeks postirradiation compared with that in the nonirradiated mice. Conclusion In mice, spinal epidural fibrosis develops in the late stages after high-dose irradiation, and overexpression of transforming growth factor beta 1 occurs in a manner similar to that seen in radiation-induced fibrosis in other tissue. Additionally, thinning of the arachnoid barrier cell layer was observed in the late stages after irradiation. Thus, consideration should be given to the possibility that these phenomena can occur as

  9. Guidance, Navigation, and Control Considerations for Nuclear Thermal Propulsion

    NASA Technical Reports Server (NTRS)

    Houts, Michael G.; Mitchell, Doyce P.; Kim, Tony

    2015-01-01

    The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation NTP system could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of a first generation NTP in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NTP project could also help enable high performance fission power systems and Nuclear Electric Propulsion (NEP). Guidance, navigation, and control of NTP may have some unique but manageable characteristics.

  10. Patenting the bomb: nuclear weapons, intellectual property, and technological control.

    PubMed

    Wellerstein, Alex

    2008-03-01

    During the course of the Manhattan Project, the U.S. government secretly attempted to acquire a monopoly on the patent rights for inventions used in the production of nuclear weapons and nuclear energy. The use of patents as a system of control, while common for more mundane technologies, would seem at first glance to conflict with the regimes of secrecy that have traditionally been associated with nuclear weapons. In explaining the origins and operations of the Manhattan Project patent system, though, this essay argues that the utilization of patents was an ad hoc attempt at legal control of the atomic bomb by Manhattan Project administrators, focused on the monopolistic aspects of the patent system and preexisting patent secrecy legislation. From the present perspective, using patents as a method of control for such weapons seems inadequate, if not unnecessary; but at the time, when the bomb was a new and essentially unregulated technology, patents played an important role in the thinking of project administrators concerned with meaningful postwar control of the bomb. PMID:18505023

  11. Decontamination of control rod housing from Palisades Nuclear Power Station.

    SciTech Connect

    Kaminski, M.D.; Nunez, L.; Purohit, A.

    1999-05-03

    Argonne National Laboratory has developed a novel decontamination solvent for removing oxide scales formed on ferrous metals typical of nuclear reactor piping. The decontamination process is based on the properties of the diphosphonic acids (specifically 1-hydroxyethane-1,1-diphosphonic acid or HEDPA) coupled with strong reducing-agents (e.g., sodium formaldehyde sulfoxylate, SFS, and hydroxylamine nitrate, HAN). To study this solvent further, ANL has solicited actual stainless steel piping material that has been recently removed from an operating nuclear reactor. On March 3, 1999 ANL received segments of control rod housing from Consumers Energy's Palisades Nuclear Plant (Covert, MI) containing radioactive contamination from both neutron activation and surface scale deposits. Palisades Power plant is a PWR type nuclear generating plant. A total of eight segments were received. These segments were from control rod housing that was in service for about 6.5 years. Of the eight pieces that were received two were chosen for our experimentation--small pieces labeled Piece A and Piece B. The wetted surfaces (with the reactor's pressurized water coolant/moderator) of the pieces were covered with as a scale that is best characterized visually as a smooth, shiny, adherent, and black/brown in color type oxide covering. This tenacious oxide could not be scratched or removed except by aggressive mechanical means (e.g., filing, cutting).

  12. Advanced interaction media in nuclear power plant control rooms.

    PubMed

    Stephane, Lucas

    2012-01-01

    The shift from analog to digital Instruments (related mainly to information visualization) and Controls in Nuclear Power Plant Main Control Rooms (NPP MCR) is a central current topic of investigation. In NPP MCR, digitalization was implemented gradually, analog and digital systems still coexisting for the two main systems related to safety--Safety Instruments and Control System (SICS) and Process Instruments and Controls System (PICS). My ongoing research focuses on the introduction of Advanced Interaction Media (AIM) such as stereoscopic 3D visualization and multi-touch surfaces in control rooms. This paper proposes a Safety-Centric approach for gathering the Design Rationale needed in the specification of such novel AIM concepts as well as their evaluation through user tests. Beyond methodological research, the final output of the current research is to build an experimental simulator aiming to enhance improvements in Human-Systems Integration (HSI). This paper provides an overview of the topics under consideration. PMID:22317419

  13. Robotic control architecture development for automated nuclear material handling systems

    SciTech Connect

    Merrill, R.D.; Hurd, R.; Couture, S.; Wilhelmsen, K.

    1995-02-01

    Lawrence Livermore National Laboratory (LLNL) is engaged in developing automated systems for handling materials for mixed waste treatment, nuclear pyrochemical processing, and weapon components disassembly. In support of these application areas there is an extensive robotic development program. This paper will describe the portion of this effort at LLNL devoted to control system architecture development, and review two applications currently being implemented which incorporate these technologies.

  14. Simulation of the control board of an experimental nuclear reactor

    SciTech Connect

    Mackieh, A.; Cilingir, C.; Alten, S.

    1995-12-31

    This study is performed as a part of a bigger project to analyze human factors in operations of an experimental nuclear reactor. In this context, the control board of the 10-kW university training reactor (UTR-10) located at Iowa State University, Ames, Iowa, was simulated. The software was developed in the ergonomics laboratory of the Middle East Technical University (METU) by using an object-oriented programming language (Visual Basic for IBM-compatible personal computers).

  15. Methods of Verification, Accountability and Control of Special Nuclear Material

    SciTech Connect

    Stewart, J.E.

    1999-05-03

    This session demonstrates nondestructive assay (NDA) measurement, surveillance and analysis technology required to protect, control and account (MPC and A) for special nuclear materials (SNM) in sealed containers. These measurements, observations and analyses comprise state-of-the art, strengthened, SNM safeguards systems. Staff member specialists, actively involved in research, development, training and implementation worldwide, will present six NDA verification systems and two software tools for integration and analysis of facility MPC and A data.

  16. WTEC panel report on European nuclear instrumentation and controls

    NASA Technical Reports Server (NTRS)

    White, James D.; Lanning, David D.; Beltracchi, Leo; Best, Fred R.; Easter, James R.; Oakes, Lester C.; Sudduth, A. L.

    1991-01-01

    Control and instrumentation systems might be called the 'brain' and 'senses' of a nuclear power plant. As such they become the key elements in the integrated operation of these plants. Recent developments in digital equipment have allowed a dramatic change in the design of these instrument and control (I&C) systems. New designs are evolving with cathode ray tube (CRT)-based control rooms, more automation, and better logical information for the human operators. As these new advanced systems are developed, various decisions must be made about the degree of automation and the human-to-machine interface. Different stages of the development of control automation and of advanced digital systems can be found in various countries. The purpose of this technology assessment is to make a comparative evaluation of the control and instrumentation systems that are being used for commercial nuclear power plants in Europe and the United States. This study is limited to pressurized water reactors (PWR's). Part of the evaluation includes comparisons with a previous similar study assessing Japanese technology.

  17. Cytochrome c oxidase: Evolution of control via nuclear subunit addition☆

    PubMed Central

    Pierron, Denis; Wildman, Derek E.; Hüttemann, Maik; Markondapatnaikuni, Gopi Chand; Aras, Siddhesh; Grossman, Lawrence I.

    2014-01-01

    According to theory, present eukaryotic cells originated from a beneficial association between two free-living cells. Due to this endosymbiotic event the pre-eukaryotic cell gained access to oxidative phosphorylation (OXPHOS), which produces more than 15 times as much ATP as glycolysis. Because cellular ATP needs fluctuate and OXPHOS both requires and produces entities that can be toxic for eukaryotic cells such as ROS or NADH, we propose that the success of endosymbiosis has largely depended on the regulation of endosymbiont OXPHOS. Several studies have presented cytochrome c oxidase as a key regulator of OXPHOS; for example, COX is the only complex of mammalian OXPHOS with known tissue-specific isoforms of nuclear encoded subunits. We here discuss current knowledge about the origin of nuclear encoded subunits and the appearance of different isozymes promoted by tissue and cellular environments such as hypoxia. We also review evidence for recent selective pressure acting on COX among vertebrates, particularly in primate lineages, and discuss the unique pattern of co-evolution between the nuclear and mitochondrial genomes. Finally, even though the addition of nuclear encoded subunits was a major event in eukaryotic COX evolution, this does not lead to emergence of a more efficient COX, as might be expected from an anthropocentric point of view, for the “higher” organism possessing large brains and muscles. The main function of these subunits appears to be “only” to control the activity of the mitochondrial subunits. We propose that this control function is an as yet underappreciated key point of evolution. Moreover, the importance of regulating energy supply may have caused the addition of subunits encoded by the nucleus in a process comparable to a “domestication scenario” such that the host tends to control more and more tightly the ancestral activity of COX performed by the mtDNA encoded subunits. This article is part of a Special Issue entitled

  18. Cytochrome c oxidase: evolution of control via nuclear subunit addition.

    PubMed

    Pierron, Denis; Wildman, Derek E; Hüttemann, Maik; Markondapatnaikuni, Gopi Chand; Aras, Siddhesh; Grossman, Lawrence I

    2012-04-01

    According to theory, present eukaryotic cells originated from a beneficial association between two free-living cells. Due to this endosymbiotic event the pre-eukaryotic cell gained access to oxidative phosphorylation (OXPHOS), which produces more than 15 times as much ATP as glycolysis. Because cellular ATP needs fluctuate and OXPHOS both requires and produces entities that can be toxic for eukaryotic cells such as ROS or NADH, we propose that the success of endosymbiosis has largely depended on the regulation of endosymbiont OXPHOS. Several studies have presented cytochrome c oxidase as a key regulator of OXPHOS; for example, COX is the only complex of mammalian OXPHOS with known tissue-specific isoforms of nuclear encoded subunits. We here discuss current knowledge about the origin of nuclear encoded subunits and the appearance of different isozymes promoted by tissue and cellular environments such as hypoxia. We also review evidence for recent selective pressure acting on COX among vertebrates, particularly in primate lineages, and discuss the unique pattern of co-evolution between the nuclear and mitochondrial genomes. Finally, even though the addition of nuclear encoded subunits was a major event in eukaryotic COX evolution, this does not lead to emergence of a more efficient COX, as might be expected from an anthropocentric point of view, for the "higher" organism possessing large brains and muscles. The main function of these subunits appears to be "only" to control the activity of the mitochondrial subunits. We propose that this control function is an as yet under appreciated key point of evolution. Moreover, the importance of regulating energy supply may have caused the addition of subunits encoded by the nucleus in a process comparable to a "domestication scenario" such that the host tends to control more and more tightly the ancestral activity of COX performed by the mtDNA encoded subunits. PMID:21802404

  19. Lipid partitioning at the nuclear envelope controls membrane biogenesis

    PubMed Central

    Barbosa, Antonio Daniel; Sembongi, Hiroshi; Su, Wen-Min; Abreu, Susana; Reggiori, Fulvio; Carman, George M.; Siniossoglou, Symeon

    2015-01-01

    Partitioning of lipid precursors between membranes and storage is crucial for cell growth, and its disruption underlies pathologies such as cancer, obesity, and type 2 diabetes. However, the mechanisms and signals that regulate this process are largely unknown. In yeast, lipid precursors are mainly used for phospholipid synthesis in nutrient-rich conditions in order to sustain rapid proliferation but are redirected to triacylglycerol (TAG) stored in lipid droplets during starvation. Here we investigate how cells reprogram lipid metabolism in the endoplasmic reticulum. We show that the conserved phosphatidate (PA) phosphatase Pah1, which generates diacylglycerol from PA, targets a nuclear membrane subdomain that is in contact with growing lipid droplets and mediates TAG synthesis. We find that cytosol acidification activates the master regulator of Pah1, the Nem1-Spo7 complex, thus linking Pah1 activity to cellular metabolic status. In the absence of TAG storage capacity, Pah1 still binds the nuclear membrane, but lipid precursors are redirected toward phospholipids, resulting in nuclear deformation and a proliferation of endoplasmic reticulum membrane. We propose that, in response to growth signals, activation of Pah1 at the nuclear envelope acts as a switch to control the balance between membrane biogenesis and lipid storage. PMID:26269581

  20. Protein quality control at the inner nuclear membrane

    PubMed Central

    Khmelinskii, Anton; Blaszczak, Ewa; Pantazopoulou, Marina; Fischer, Bernd; Omnus, Deike J.; Le Dez, Gaëlle; Brossard, Audrey; Gunnarsson, Alexander; Barry, Joseph D.; Meurer, Matthias; Kirrmaier, Daniel; Boone, Charles; Huber, Wolfgang; Rabut, Gwenaël; Ljungdahl, Per O.; Knop, Michael

    2015-01-01

    The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm. The inner nuclear membrane (INM) functions in essential nuclear processes including chromatin organization and regulation of gene expression1. The outer nuclear membrane is continuous with the endoplasmic reticulum (ER) and is the site of membrane protein synthesis. Protein homeostasis in this compartment is ensured by ER-associated protein degradation (ERAD) pathways that in yeast involve the integral membrane E3 ubiquitin ligases Hrd1 and Doa10 operating with the E2 ubiquitin-conjugating enzymes Ubc6 and Ubc72,3. However, little is known regarding protein quality control at the INM. Here we describe a protein degradation pathway at the INM mediated by the Asi complex consisting of the RING domain proteins Asi1 and Asi34. We report that the As complex functions together with the ubiquitin conjugating enzymes Ubc6andUbc7to degrade soluble and integral membrane proteins. Genetic evidence suggest that the Asi ubiquitin ligase defines a pathway distinct from but complementary to ERAD. Using unbiased screening with a novel genome-wide yeast library based on a tandem fluorescent protein timer (tFT)5, we identify more than 50 substrates of the Asi, Hrd1 and Doa10 E3 ubiquity ligases. We show that the Asi ubiquitin ligase is involved in degradation of mislocalised integral membrane proteins, thus acting to maintain and safeguard the identity of the INM. PMID:25519137

  1. 76 FR 22849 - DoD Unclassified Controlled Nuclear Information (UCNI)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... of the Secretary 32 CFR Part 223 RIN 0790-AI64 DoD Unclassified Controlled Nuclear Information (UCNI... responsibilities for controlling Department of Defense (DoD) Unclassified Controlled Nuclear Information (UCNI) in... levels of Government. List of Subjects in 32 CFR Part 223 National defense, Nuclear energy, Reporting...

  2. Automated Microwave Frequency Control in Dynamic Nuclear Polarization Experiments

    NASA Astrophysics Data System (ADS)

    Scott, Ethan; Johnson, Ian; Keller, Dustin; Solid Polarized Target Group Team

    2016-03-01

    To achieve highest polarization levels in dynamic nuclear polarization (DNP) experiments, target materials must be subjected to microwave irradiation at a particular frequency determined by the difference in the nuclear Larmor and electron paramagnetic resonance (EPR) frequencies. However, this resonant frequency is variable; it drifts as a result of radiation damage. Manually adjusting the frequency to accommodate for this fluctuation can be difficult, and improper adjustments negatively impact the polarization. In response to this problem, a controller has been developed which automates the process of seeking and maintaining optimal frequency. The creation of such a controller has necessitated research into the correlation between microwave frequency and corresponding polarization growth or decay rates in DNP experiments. Knowledge gained from the research of this unique relationship has additionally lead to the development of a Monte-Carlo simulation which accurately models polarization as a function of frequency and a number of other parameters. The simulation and controller continue to be refined, however, recent DNP experimentation has confirmed the controller's effectiveness.

  3. An Approach to Autonomous Control for Space Nuclear Power Systems

    SciTech Connect

    Wood, Richard Thomas; Upadhyaya, Belle R.

    2011-01-01

    Under Project Prometheus, the National Aeronautics and Space Administration (NASA) investigated deep space missions that would utilize space nuclear power systems (SNPSs) to provide energy for propulsion and spacecraft power. The initial study involved the Jupiter Icy Moons Orbiter (JIMO), which was proposed to conduct in-depth studies of three Jovian moons. Current radioisotope thermoelectric generator (RTG) and solar power systems cannot meet expected mission power demands, which include propulsion, scientific instrument packages, and communications. Historically, RTGs have provided long-lived, highly reliable, low-power-level systems. Solar power systems can provide much greater levels of power, but power density levels decrease dramatically at {approx} 1.5 astronomical units (AU) and beyond. Alternatively, an SNPS can supply high-sustained power for space applications that is both reliable and mass efficient. Terrestrial nuclear reactors employ varying degrees of human control and decision-making for operations and benefit from periodic human interaction for maintenance. In contrast, the control system of an SNPS must be able to provide continuous operatio for the mission duration with limited immediate human interaction and no opportunity for hardware maintenance or sensor calibration. In effect, the SNPS control system must be able to independently operate the power plant while maintaining power production even when subject to off-normal events and component failure. This capability is critical because it will not be possible to rely upon continuous, immediate human interaction for control due to communications delays and periods of planetary occlusion. In addition, uncertainties, rare events, and component degradation combine with the aforementioned inaccessibility and unattended operation to pose unique challenges that an SNPS control system must accommodate. Autonomous control is needed to address these challenges and optimize the reactor control design.

  4. Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.

    PubMed

    Bassi, C; Ho, J; Srikumar, T; Dowling, R J O; Gorrini, C; Miller, S J; Mak, T W; Neel, B G; Raught, B; Stambolic, V

    2013-07-26

    Loss of function of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor gene is associated with many human cancers. In the cytoplasm, PTEN antagonizes the phosphatidylinositol 3-kinase (PI3K) signaling pathway. PTEN also accumulates in the nucleus, where its function remains poorly understood. We demonstrate that SUMOylation (SUMO, small ubiquitin-like modifier) of PTEN controls its nuclear localization. In cells exposed to genotoxic stress, SUMO-PTEN was rapidly excluded from the nucleus dependent on the protein kinase ataxia telangiectasia mutated (ATM). Cells lacking nuclear PTEN were hypersensitive to DNA damage, whereas PTEN-deficient cells were susceptible to killing by a combination of genotoxic stress and a small-molecule PI3K inhibitor both in vitro and in vivo. Our findings may have implications for individualized therapy for patients with PTEN-deficient tumors. PMID:23888040

  5. A Balance between Nuclear and Cytoplasmic Volumes Controls Spindle Length

    PubMed Central

    Novakova, Lucia; Kovacovicova, Kristina; Dang-Nguyen, Thanh Quang; Sodek, Martin; Skultety, Michal; Anger, Martin

    2016-01-01

    Proper assembly of the spindle apparatus is crucially important for faithful chromosome segregation during anaphase. Thanks to the effort over the last decades, we have very detailed information about many events leading to spindle assembly and chromosome segregation, however we still do not understand certain aspects, including, for example, spindle length control. When tight regulation of spindle size is lost, chromosome segregation errors emerge. Currently, there are several hypotheses trying to explain the molecular mechanism of spindle length control. The number of kinetochores, activity of molecular rulers, intracellular gradients, cell size, limiting spindle components, and the balance of the spindle forces seem to contribute to spindle size regulation, however some of these mechanisms are likely specific to a particular cell type. In search for a general regulatory mechanism, in our study we focused on the role of cell size and nuclear to cytoplasmic ratio in this process. To this end, we used relatively large cells isolated from 2-cell mouse embryos. Our results showed that the spindle size upper limit is not reached in these cells and suggest that accurate control of spindle length requires balanced ratio between nuclear and cytoplasmic volumes. PMID:26886125

  6. Nuclear material control and accounting safeguards in the United States

    SciTech Connect

    Woltermann, H.A.; Rudy, C.R.; Rakel, D.A.; DeVer, E.A.

    1982-07-01

    Material control and accounting (MC and A) of special nuclear material (SNM) must supplement physical security to protect SNM from unlawful use such as terrorist activities. This article reviews MC and A safeguards of SNM in the United States. The following topics are covered: a brief perspective and history of MC and A safeguards, current MC and A practices, measurement methods for SNM, historical MC and A performance, a description of near-real-time MC and A systems, and conclusions on the status of MC and A in the United States.

  7. Nuclear power plant control room operators' performance research

    SciTech Connect

    Gray, L.H.; Haas, P.M.

    1984-01-01

    A research program is being conducted to provide information on the performance of nuclear power plant control room operators when responding to abnormal/emergency events in the plants and in full-scope training simulators. The initial impetus for this program was the need for data to assess proposed design criteria for the choice of manual versus automatic action for accomplishing safety-related functions during design basis accidents. The program also included studies of training simulator capabilities, of procedures and data for specifying and verifying simulator performance, and of methods and applications of task analysis.

  8. Radioactive Iodine and Krypton Control for Nuclear Fuel Reprocessing Facilities

    SciTech Connect

    N. R. Soelberg; J. D. Law; T. G. Garn; M. Greenhalgh; R. T. Jubin; P. Thallapally; D. M. Strachan

    2013-08-01

    The removal of volatile radionuclides generated during used nuclear fuel reprocessing in the US is almost certain to be necessary for the licensing of a reprocessing facility in the US. Various control technologies have been developed, tested, or used over the past 50 years for control of volatile radionuclide emissions from used fuel reprocessing plants. The US DOE has sponsored, since 2009, an Off-gas Sigma Team to perform research and development focused on the most pressing volatile radionuclide control and immobilization problems. In this paper, we focus on the control requirements and methodologies for 85Kr and 129I. Numerous candidate technologies have been studied and developed at laboratory and pilot-plant scales in an effort to meet the need for high iodine control efficiency and to advance alternatives to cryogenic separations for krypton control. Several of these show promising results. Iodine decontamination factors as high as 105, iodine loading capacities, and other adsorption parameters including adsorption rates have been demonstrated under some conditions for both silver zeolite (AgZ) and Ag-functionalized aerogel. Sorbents, including an engineered form of AgZ and selected metal organic framework materials (MOFs), have been successfully demonstrated to capture Kr and Xe without the need for separations at cryogenic temperatures.

  9. Nuclear Technology Series. Course 14: Introduction to Quality Assurance/Quality Control.

    ERIC Educational Resources Information Center

    Technical Education Research Center, Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  10. Nuclear Technology Series. Course 6: Instrumentation and Control of Reactors and Plant Systems.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  11. Nuclear positional control of HIV transcription in 4D

    PubMed Central

    Dhir, Somdutta; Dieudonné, Mariacarolina

    2010-01-01

    Retroviruses integrate their genome into the chromatin of the host cell and are subject to the same control mechanisms governing transcription in the nucleus. There is increasing evidence that the spatial position of a gene within the nucleus in time affects its activity. Therefore it becomes important to study the chromatin environment in space and time of the HIV-1 provirus, particularly in cells where a tight transcriptional control allows the virus to hide away from antiviral treatment and immune response. We recently showed that the HIV-1 provirus is found at the nuclear periphery of latently infected lymphocytes associated in trans with centromeric heterochromatin. After induction of transcription, this association was lost, although the location of the transcribing provirus remained peripheral. Our results reveal a novel mechanism of transcriptional silencing involved in HIV-1 post-transcriptional latency and open wider perspectives for the general organization of chromatin in the nucleus. PMID:21327098

  12. Life Extension of a Nuclear Facility: Export Control Implications

    SciTech Connect

    Kerschner, Harrison F.; Cunningham, Julia A.; Sportelli, James M.; Yarbro, Steve; Bedell, Jeffrey J.

    2010-04-11

    This paper discusses life extension upgrades to an operational nuclear research facility and identifies export control implications. The Department of Energy (DOE) is engaged in a multi-year program of deactivating and decommissioning (D&D) the majority of the Hanford Site 300 Area facilities. In 2006, the DOE decided to retain the Pacific Northwest National Laboratory’s Radiochemical Processing Laboratory (RPL), which was on the D&D list. As part of the facility life-extension to ensure continued mission capability, the DOE decided to consolidate replacement hot cell capability into the RPL. Physical limitations within the facility dictated that new hot cell design and construction would be modularized—a process that allows for ease of fabrication and introduction into existing space. A review of the fabrication and installation techniques has identified potential export control issues.

  13. Reactivity Control Schemes for Fast Spectrum Space Nuclear Reactors

    SciTech Connect

    Craft, Aaron E.; King, Jeffrey C.

    2008-01-21

    Several different reactivity control schemes are considered for future space nuclear reactor power systems. Each of these control schemes uses a combination of boron carbide absorbers and/or beryllium oxide reflectors to achieve sufficient reactivity swing to keep the reactor subcritical during launch and to provide sufficient excess reactivity to operate the reactor over its expected 7-15 year lifetime. The size and shape of the control system directly impacts the size and mass of the space reactor's reflector and shadow shield, leading to a tradeoff between reactivity swing and total system mass. This paper presents a trade study of drum, shutter, and petal control schemes based on reactivity swing and mass effects for a representative fast-spectrum, gas-cooled reactor. For each control scheme, the dimensions and composition of the core are constant, and the reflector is sized to provide $5 of cold-clean excess reactivity with each configuration in its most reactive state. The advantages and disadvantages of each configuration are discussed, along with optimization techniques and novel geometric approaches for each scheme.

  14. Control of information as an element of nuclear safeguards

    SciTech Connect

    Green, J.N.

    1982-03-01

    Control of information as an element of physical protection has a long history in the field of national security. The nuclear industry is familiar with the constraints on proprietary information; and, with an effective date of October 1, 1980 for Parts 25 and 95 in Title 10 of the code of Federal Regulations, certain activities had to cope with rules for safeguarding of classified information. In applying the rules it is important to understand the differences between national security information and restricted data, and how guidance is promulgated both by the Nuclear Regulatory Commission (NRC) and by the Department of Energy. More recently, with a fully effective date of January 20, 1982, the NRC published rules for the protection of unclassified safeguards information. The scope is much broader than for the classified information. For example, the rules are applicable to power reactors. In this paper the directives which provide the details for compliance with all these rules are identified, and their application is discussed. NRC inspectors will be checking for compliance with the rules. Once problems of compliance are resolved, the more difficult question of evaluating the impact of information control procedures on the effectiveness of a physical protection system can be addressed.

  15. Antecedents to and outcomes of Rh(D) isoimmunization: Mater Mothers Hospital, Brisbane, 1988-1995.

    PubMed

    Portmann, C; Ludlow, J; Joyce, A; Chan, F Y

    1997-02-01

    We analyzed the antecedents and outcomes of Rh(D) isoimmunization in a local population. Forty-two Rh(D) isoimmunized women attending Mater Mothers Hospital for antenatal care were identified through the Mater Hospital Blood Bank database; their records were reviewed for variables including sensitizing events, obstetric interventions and pregnancy outcomes. In this group, 74% of women became sensitized despite receiving anti-D immune globulin, 17% did not receive anti-D appropriately and the other failed to attend for treatment of bleeding in pregnancy. Antenatal sensitization was implicated in 6 women (14%) and potentially responsible for isoimmunization in another 18. Over half of the 80 viable pregnancies in this study group required some form of obstetric intervention. Thirty pregnancies required amniocentesis and 1 in 3 babies underwent either intrauterine or exchange transfusion. Three fetal deaths occurred as a result of severe disease. This study offers information highlighting circumstances in which immunoprophylaxis guidelines have failed to impart protection against Rh(D) sensitization and the consequences of such failures. PMID:9075540

  16. Immunohistochemical profile of neurotrophins in human cranial dura mater and meningiomas.

    PubMed

    Artico, Marco; Bronzetti, Elena; Pompili, Elena; Ionta, Brunella; Alicino, Valentina; D'Ambrosio, Anna; Santoro, Antonio; Pastore, Francesco S; Elenkov, Ilia; Fumagalli, Lorenzo

    2009-06-01

    The immunohistochemical profile of neurotrophins and their receptors in the human cranial dura mater was studied by examining certain dural zones in specimens harvested from different regions (frontal, temporal, parietal and occipital). Dural specimens were obtained during neurosurgical operations performed in ten patients for surgical treatment of intracranial lesions (meningiomas, traumas, gliomas, vascular malformations). The dural fragments were taken from the area of the craniotomy at least 8 cm from the lesion as well as from the area in which the meningioma had its dural attachment. Immunohistochemical characterization and distribution of neurotrophins, with their receptors, were analyzed. The concrete role played by these neurotrophic factors in general regulation, vascular permeability, algic responsivity and release of locally active substances in the human dura mater is still controversial. Our study revealed a general structural alteration of dural tissue due to the invasivity of meningiomatous lesions, together with an improved expression of brain derived neurotrophic factor (BDNF) in highly proliferating neoplastic cells and an evident production of nerve growth factor (NGF) in inflammatory cells, suggesting that BDNF has a role in supporting the proliferation rate of neoplastic cells, while NGF is involved in the activation of a chronic inflammatory response in neoplastic areas. PMID:19424612

  17. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.8 Subject areas eligible to be...

  18. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.8 Subject areas eligible to be...

  19. MATER - Pianeta Terra-Mare: an interactive and multidisciplinary approach to Geosphere sciences

    NASA Astrophysics Data System (ADS)

    Piangiamore, Giovanna Lucia; Fanelli, Emanuela; Furia, Stefania; Garau, Daniela; Merlino, Silvia; Musacchio, Gemma; Carla Centineo, Maria

    2016-04-01

    Recent studies demonstrate that Earth and Marine Sciences are not properly treated in scholastic programs and in textbooks are included in a superficial way. These topics are interdisciplinary and experimental (biology, ecology, oceanography and geology) and the recent advance in these fields is strictly linked to technologic improvement. School cannot keep up with the huge advances of knowledge experimented in the last 20 years, also for the lack of didactic laboratories sufficiently updated to support experimental activities. In this context, in 2014-15 three Italian Research Institutes (INGV, ISMAR-CNR and ENEA-CRAM) have decided to support the Unified School District "ISA 10"of Lerici (Liguria, Italy) - comprehensive of kindergartner, primary and middle schools - to develop the project MATER - Pianeta Terra-Mare (Planet Earth and Sea). The acronym MATER (MARe and TERra) has also a gender value, as people involved in the projects were women, mostly researchers and teachers, which have worked side by side with other women belonging to environmental and cultural associations of the territory. This heterogeneous group has a common objective: to promote the diffusion of a scientific culture and to sensitize students from 3 to 14 years towards problems occurring in marine and terrestrial environments, fostering the settlement of a sustainable attitude to the exploitation of natural resources and consciousness to natural hazards, such as earthquakes and floods, quite common in the Ligurian region. MATER has been considered as one of the best projects funded by MIUR (Italian Ministry of Education, University and Research) inside the Dissemination of Scientific and Technological Culture call for the year 2014. Natural hazards (Planet Earth) and the chemical-physical aspects and resources of the marine environment (Planet Sea) were the two modules of the project. Planet Earth developed through Piovono Idee! (Cloudy with a chance of Ideas!), an interactive exhibition on

  20. Information Foraging in Nuclear Power Plant Control Rooms

    SciTech Connect

    R.L. Boring

    2011-09-01

    nformation foraging theory articulates the role of the human as an 'informavore' that seeks information and follows optimal foraging strategies (i.e., the 'information scent') to find meaningful information. This paper briefly reviews the findings from information foraging theory outside the nuclear domain and then discusses the types of information foraging strategies operators employ for normal and off-normal operations in the control room. For example, operators may employ a predatory 'wolf' strategy of hunting for information in the face of a plant upset. However, during routine operations, the operators may employ a trapping 'spider' strategy of waiting for relevant indicators to appear. This delineation corresponds to information pull and push strategies, respectively. No studies have been conducted to determine explicitly the characteristics of a control room interface that is optimized for both push and pull information foraging strategies, nor has there been empirical work to validate operator performance when transitioning between push and pull strategies. This paper explores examples of control room operators as wolves vs. spiders and con- cludes by proposing a set of research questions to investigate information foraging in control room settings.

  1. Nuclear fuel pellet quality control using artificial intelligence techniques

    NASA Astrophysics Data System (ADS)

    Song, Xiaolong

    Inspection of nuclear fuel pellets is a complex and time-consuming process. At present, quality control in the fuel fabrication field mainly relies on human manual inspection, which is essentially a judgement call. Considering the high quality requirement of fuel pellets in the nuclear industry, pellet inspection systems must have a high accuracy rate in addition to a high inspection speed. Furthermore, any inspection process should have a low rejection rate of good pellets from the manufacturer point of view. It is very difficult to use traditional techniques, such as simple image comparison, to adequately perform the inspection process of the nuclear fuel pellet. Knowledge-based inspection and a defect-recognition algorithm, which maps the human inspection knowledge, is more robust and effective. A novel method is introduced here for pellet image processing. Three artificial intelligence techniques are studied and applied for fuel pellet inspection in this research. They are an artificial neural network, fuzzy logic, and the decision tree method. A dynamic reference model is located on each input fuel pellet image. Then, those pixels that belong to the abnormal defect are enhanced with high speed and high accuracy. Next, the content-based features for the defect are extracted from those abno1mal pixels and used in the inspection algorithm. Finally, an automated inspection prototype system---Visual Inspection Studio---which combines machine vision and these three AI techniques, is developed and tested. The experimental results indicate a very successful system with a high potential for on-line automatic inspection process.

  2. HFE safety reviews of advanced nuclear power plant control rooms

    NASA Technical Reports Server (NTRS)

    Ohara, John

    1994-01-01

    Advanced control rooms (ACR's) will utilize human-system interface (HSI) technologies that may have significant implications for plant safety in that they will affect the operator's overall role and means of interacting with the system. The Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) aspects of HSI's to ensure that they are designed to good HFE principles and support performance and reliability in order to protect public health and safety. However, the only available NRC guidance was developed more than ten years ago, and does not adequately address the human performance issues and technology changes associated with ACR's. Accordingly, a new approach to ACR safety reviews was developed based upon the concept of 'convergent validity'. This approach to ACR safety reviews is described.

  3. Flammability Control In A Nuclear Waste Vitrification System

    SciTech Connect

    Zamecnik, John R.; Choi, Alexander S.; Johnson, Fabienne C.; Miller, Donald H.; Lambert, Daniel P.; Stone, Michael E.; Daniel, William E. Jr.

    2013-07-25

    The Defense Waste Processing Facility at the Savannah River Site processes high-level radioactive waste from the processing of nuclear materials that contains dissolved and precipitated metals and radionuclides. Vitrification of this waste into borosilicate glass for ultimate disposal at a geologic repository involves chemically modifying the waste to make it compatible with the glass melter system. Pretreatment steps include removal of excess aluminum by dissolution and washing, and processing with formic and nitric acids to: 1) adjust the reduction-oxidation (redox) potential in the glass melter to reduce radionuclide volatility and improve melt rate; 2) adjust feed rheology; and 3) reduce by steam stripping the amount of mercury that must be processed in the melter. Elimination of formic acid in pretreatment has been studied to eliminate the production of hydrogen in the pretreatment systems, which requires nuclear grade monitoring equipment. An alternative reductant, glycolic acid, has been studied as a substitute for formic acid. However, in the melter, the potential for greater formation of flammable gases exists with glycolic acid. Melter flammability is difficult to control because flammable mixtures can be formed during surges in offgases that both increase the amount of flammable species and decrease the temperature in the vapor space of the melter. A flammable surge can exceed the 60% of the LFL with no way to mitigate it. Therefore, careful control of the melter feed composition based on scaled melter surge testing is required. The results of engineering scale melter tests with the formic-nitric flowsheet and the use of these data in the melter flammability model are presented.

  4. Neural net controlled tag gas sampling system for nuclear reactors

    DOEpatents

    Gross, K.C.; Laug, M.T.; Lambert, J.B.; Herzog, J.P.

    1997-02-11

    A method and system are disclosed for providing a tag gas identifier to a nuclear fuel rod and analyze escaped tag gas to identify a particular failed nuclear fuel rod. The method and system include disposing a unique tag gas composition into a plenum of a nuclear fuel rod, monitoring gamma ray activity, analyzing gamma ray signals to assess whether a nuclear fuel rod has failed and is emitting tag gas, activating a tag gas sampling and analysis system upon sensing tag gas emission from a failed nuclear rod and evaluating the escaped tag gas to identify the particular failed nuclear fuel rod. 12 figs.

  5. Neural net controlled tag gas sampling system for nuclear reactors

    DOEpatents

    Gross, Kenneth C.; Laug, Matthew T.; Lambert, John D. B.; Herzog, James P.

    1997-01-01

    A method and system for providing a tag gas identifier to a nuclear fuel rod and analyze escaped tag gas to identify a particular failed nuclear fuel rod. The method and system include disposing a unique tag gas composition into a plenum of a nuclear fuel rod, monitoring gamma ray activity, analyzing gamma ray signals to assess whether a nuclear fuel rod has failed and is emitting tag gas, activating a tag gas sampling and analysis system upon sensing tag gas emission from a failed nuclear rod and evaluating the escaped tag gas to identify the particular failed nuclear fuel rod.

  6. 77 FR 43506 - DoD Unclassified Controlled Nuclear Information (UCNI)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    .... SUPPLEMENTARY INFORMATION: The Department of Defense published a proposed rule on April 25, 2011 (76 FR 22849... of the Secretary 32 CFR Part 223 RIN 0790-AI64 DoD Unclassified Controlled Nuclear Information (UCNI... responsibilities for controlling Department of Defense (DoD) Unclassified Controlled Nuclear Information (UCNI)...

  7. The nuclear receptor NR2E1/TLX controls senescence

    PubMed Central

    Krusche, Benjamin; Pemberton, Helen; Alonso, Marta M.; Chandler, Hollie; Brookes, Sharon; Parrinello, Simona; Peters, Gordon; Gil, Jesús

    2014-01-01

    The nuclear receptor NR2E1 (also known as TLX or tailless) controls the self-renewal of neural stem cells (NSCs) and has been implied as an oncogene which initiates brain tumours including glioblastomas. Despite NR2E1 regulating targets like p21CIP1 or PTEN we still lack a full explanation for its role in NSC self-renewal and tumorigenesis. We know that Polycomb repressive complexes (PRC) also control stem cell self-renewal and tumorigenesis, but so far, no formal connection has been established between NR2E1 and PRCs. In a screen for transcription factors regulating the expression of the Polycomb protein CBX7, we identified NR2E1 as one of its more prominent regulators. NR2E1 binds at the CBX7 promoter, inducing its expression. Notably CBX7 represses NR2E1 as part of a regulatory loop. Ectopic NR2E1 expression inhibits cellular senescence, extending cellular lifespan in fibroblasts via CBX7-mediated regulation of p16INK4a and direct repression of p21CIP1. In addition NR2E1 expression also counteracts oncogene-induced senescence (OIS). The importance of NR2E1 to restrain senescence is highlighted through the process of knocking down its expression, which causes premature senescence in human fibroblasts and epithelial cells. We also confirmed that NR2E1 regulates CBX7 and restrains senescence in NSCs. Finally, we observed that the expression of NR2E1 directly correlates with that of CBX7 in human glioblastoma multiforme. Overall we identified control of senescence and regulation of Polycomb action as two possible mechanisms that can join those so far invoked to explain the role of NR2E1 in control of NSC self-renewal and cancer. PMID:25328137

  8. Use of Postmortem Human Dura Mater and Scalp for Deriving Human Fibroblast Cultures

    PubMed Central

    Bliss, Lindsay A.; Sams, Malik R.; Deep-Soboslay, Amy; Ren-Patterson, Renee; Jaffe, Andrew E.; Chenoweth, Josh G.; Jaishankar, Amritha; Kleinman, Joel E.; Hyde, Thomas M.

    2012-01-01

    Fibroblasts can be collected from deceased individuals, grown in culture, reprogrammed into induced pluripotent stem cells (iPSCs), and then differentiated into a multitude of cell types, including neurons. Past studies have generated iPSCs from somatic cell biopsies from either animal or human subjects. Previously, fibroblasts have only been successfully cultured from postmortem human skin in two studies. Here we present data on fibroblast cell cultures generated from 146 scalp and/or 53 dura mater samples from 146 postmortem human brain donors. In our overall sample, the odds of successful dural culture was almost two-fold compared with scalp (OR = 1.95, 95% CI: [1.01, 3.9], p = 0.047). Using a paired design within subjects for whom both tissues were available for culture (n = 53), the odds of success for culture in dura was 16-fold as compared to scalp (OR = 16.0, 95% CI: [2.1–120.6], p = 0.0007). Unattended death, tissue donation source, longer postmortem interval (PMI), and higher body mass index (BMI) were associated with unsuccessful culture in scalp (all p<0.05), but not in dura. While scalp cells proliferated more and grew more rapidly than dura cells [F (1, 46) = 12.94, p<0.008], both tissues could be generated and maintained as fibroblast cell lines. Using a random sample of four cases, we found that both postmortem scalp and dura could be successfully reprogrammed into iPSC lines. Our study demonstrates that postmortem dura mater, and to a lesser extent, scalp, are viable sources of living fibroblasts for culture that can be used to generate iPSCs. These tissues may be accessible through existing brain tissue collections, which is critical for studying disorders such as neuropsychiatric diseases. PMID:23028905

  9. Prescriptive concepts for advanced nuclear materials control and accountability systems

    SciTech Connect

    Whitty, W.J.; Strittmatter, R.B.; Ford, W.; Tisinger, R.M.; Meyer, T.H.

    1987-06-01

    Networking- and distributed-processing hardware and software have the potential of greatly enhancing nuclear materials control and accountability (MC and A) systems, from both safeguards and process operations perspectives, while allowing timely integrated safeguards activities and enhanced computer security at reasonable cost. A hierarchical distributed system is proposed consisting of groups of terminal and instruments in plant production and support areas connected to microprocessors that are connected to either larger microprocessors or minicomputers. These micros and/or minis are connected to a main machine, which might be either a mainframe or a super minicomputer. Data acquisition, preliminary input data validation, and transaction processing occur at the lowest level. Transaction buffering, resource sharing, and selected data processing occur at the intermediate level. The host computer maintains overall control of the data base and provides routine safeguards and security reporting and special safeguards analyses. The research described outlines the distribution of MC and A system requirements in the hierarchical system and distributed processing applied to MC and A. Implications of integrated safeguards and computer security concepts for the distributed system design are discussed. 10 refs., 4 figs.

  10. Status of radioiodine control for nuclear fuel reprocessing plants

    SciTech Connect

    Burger, L.L.; Scheele, R.D.

    1983-07-01

    This report summarizes the status of radioiodine control in a nuclear fuel reprocessing plant with respect to capture, fixation, and disposal. Where possible, we refer the reader to a number of survey documents which have been published in the last four years. We provide updates where necessary. Also discussed are factors which must be considered in developing criteria for iodine control. For capture from gas streams, silver mordenite and a silver nitrate impregnated silica (AC-6120) are considered state-of-the-art and are recommended. Three aqueous scrubbing processes have been demonstrated: Caustic scrubbing is simple but probably will not give an adequate iodine retention by itself. Mercurex (mercuric nitrate-nitric acid scrubbing) has a number of disadvantages including the use of toxic mercury. Iodox (hyperazeotropic nitric acid scrubbing) is effective but employs a very corrosive and hazardous material. Other technologies have been tested but require extensive development. The waste forms recommended for long-term storage or disposal are silver iodide, the iodates of barium, strontium, or calcium, and silver loaded sorbents, all fixed in cement. Copper iodide in bitumen (asphalt) is a possibility but requires testing. The selection of a specific form will be influenced by the capture process used.

  11. Understanding Nuclear Weapons and Arms Control: A Guide to the Issues. New Edition.

    ERIC Educational Resources Information Center

    Mayers, Teena

    Intended for secondary and college level students and teachers, this guide discusses the nuclear arms control issue. There are four sections. Section I discusses U.S. nuclear strategy from 1945 to the present, strategic nuclear weapons competition between the United States and the Union of Soviet Socialist Republics (U.S.S.R.), U.S.…

  12. 10 CFR 50.44 - Combustible gas control for nuclear power reactors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Combustible gas control for nuclear power reactors. 50.44 Section 50.44 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION... for nuclear power reactors. (a) Definitions—(1) Inerted atmosphere means a containment atmosphere...

  13. 10 CFR 50.44 - Combustible gas control for nuclear power reactors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Combustible gas control for nuclear power reactors. 50.44 Section 50.44 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION... for nuclear power reactors. (a) Definitions—(1) Inerted atmosphere means a containment atmosphere...

  14. Fault-tolerant adaptive control for load-following in static space nuclear power systems

    NASA Technical Reports Server (NTRS)

    Parlos, Alexander G.; Onbasioglu, Fetiye O.; Peddicord, Kenneth L.; Metzger, John D.

    1992-01-01

    The possible use of a dual-loop model-based adaptive control system for load following in static space nuclear power systems is investigated. The proposed approach has thus far been applied only to a thermoelectric space nuclear power system but is equally applicable to other static space nuclear power systems such as thermionic systems.

  15. Tags and seals for controling nuclear materials, Arms control and nonproliferation technologies. Second quarter 1993

    SciTech Connect

    Staehle, G; Talaber, C; Stull, S; Moulthrop, P

    1993-12-31

    This issue of Arms Control and Nonproliferation Technologies summarizes demonstrations and addresses related topics. The first article, ``Basic Nuclear Material Control and Accountability Concepts as Might be Applied to the Uranium from the US-Russian HEU Purchase,`` describes safeguards sybsystems necessary for effective nuclear material safeguards. It also presents a general discussion on HEU-to-low-enrichment uranium (LEU) commingling processes and suggests applicable key measurement points. The second article, ``A Framework for Evaluating Tamper-Indicating-Device Technologies (TIDs),`` describes their uses, proper selection, and evaluation. The final three articles discuss the tags and seals applications and general characteristics of several nuclear material containers: the Type 30B uranium hexafluoride container, the AT-400R container, and the DOT Specification 6M container for SNM. Finally, the Appendix displays short descriptions and illustrations of seven tags and seals, including: the E-cup and wire seal, the python seal, the secure loop inspectable tag/seal (SLITS), bolt-and-loop type electronic identification devices, and the shrink-wrap seal.

  16. Degradation-mediated protein quality control at the inner nuclear membrane

    PubMed Central

    Boban, Mirta; Foisner, Roland

    2016-01-01

    abstract An intricate machinery protects cells from the accumulation of misfolded, non-functional proteins and protein aggregates. Protein quality control pathways have been best described in the cytoplasm and the endoplasmic reticulum, however, recent findings indicate that the nucleus is also an important compartment for protein quality control. Several nuclear ubiquitinylation pathways target soluble and membrane proteins in the nucleus and mediate their degradation through nuclear proteasomes. In addition, emerging data suggest that nuclear envelope components are also degraded by autophagy, although the mechanisms by which cytoplasmic autophagy machineries get access to nuclear targets remain unclear. In this minireview we summarize the nuclear ubiquitin-proteasome pathways in yeast, focusing on pathways involved in the protein degradation at the inner nuclear membrane. In addition, we discuss potential mechanisms how nuclear targets at the nuclear envelope may be delivered to the cytoplasmic autophagy pathways in yeast and mammals. PMID:26760377

  17. Feedback control of nuclear spin bath for a single hole spin in a quantum dot

    NASA Astrophysics Data System (ADS)

    Pang, Hongliang; Gong, Zhirui; Yao, Wang

    2014-03-01

    In a semiconductor quantum dot, the nuclear spin bath plays an important role as the ultimate environment of an electron or hole spin at low temperature. Through dynamic nuclear spin polarization driven by an oscillating electric field, we show that feedback controls can be implemented on the nuclear spin bath of a single hole spin. The feedback controls utilize the anisotropic hyperfine interaction between the hole spin and the nuclear spins. The negative feedback can suppress the statistical fluctuations of the nuclear hyperfine field and lead to longer coherence time of the hole spin. Positive feedback can possibly lead to cat like state of nuclear spin bath. The efficiency of the controls schemes is investigated under different parameters and control strategies. The work is supported by the Croucher Foundation under the Croucher Innovation Award, and the Research Grant Council of Hong Kong (HKU706309P, HKU8/CRF/11G).

  18. Radioactive Iodine and Krypton Control for Nuclear Fuel Reprocessing Facilities

    SciTech Connect

    Soelberg, Nicolas R.; Garn, Troy; Greenhalgh, Mitchell; Law, Jack; Jubin, Robert T.; Strachan, Denis M.; Thallapally, Praveen K.

    2013-07-22

    Nuclear fission results in the production of fission products and activation products, some of which tend to be volatile during used fuel reprocessing. These can evolve in volatile species in the reprocessing facility off-gas streams, depending on the separations and reprocessing technologies that are used. Radionuclides that have been identified as “volatile radionuclides” are noble gases (most notably isotopes of Kr and Xe); 3H; 14C; and 129I. Radionuclides that tend to form volatile species that evolve into reprocessing facility off-gas systems are more challenging to efficiently control compared to radionuclides that tend to stay in solid or liquid phases. Future used fuel reprocessing facilities in the United States can require efficient capture of some volatile radionuclides in their off-gas streams to meet regulatory emission requirements. In aqueous reprocessing, these radionuclides are most commonly expected to evolve into off-gas streams in tritiated water [3H2O (T2O) and 3HHO (THO)], radioactive CO2, noble gases, and gaseous HI, I2, or volatile organic iodides. The fate and speciation of these radionuclides from a non-aqueous fuel reprocessing facility is less well known at this time, but active investigations are in progress. An Off-Gas Sigma Team was formed in late FY 2009 to integrate and coordinate the Fuel Cycle Research and Development (FCR&D) activities directed towards the capture and sequestration of the these volatile radionuclides (Jubin 2012a). The Sigma Team concept was envisioned to bring together multidisciplinary teams from across the DOE complex that would work collaboratively to solve the technical challenges and to develop the scientific basis for the capture and immobilization technologies such that the sum of the efforts was greater than the individual parts. The Laboratories currently participating in this effort are Argonne National Laboratory (ANL), Idaho National Laboratory (INL), Oak Ridge National Laboratory (ORNL), Pacific

  19. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Prohibitions on identifying Unclassified Controlled Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining...

  20. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Prohibitions on identifying Unclassified Controlled Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining...

  1. 10 CFR 1017.12 - Prohibitions on identifying Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Prohibitions on identifying Unclassified Controlled Nuclear Information. 1017.12 Section 1017.12 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining...

  2. ESCRT machinery: Damage control at the nuclear membrane.

    PubMed

    Ventimiglia, Leandro N; Martin-Serrano, Juan

    2016-06-01

    Rupture of the nuclear envelope (NE) during interphase is thought to be an infrequent event in healthy cells. Two papers recently published in Science describe the transient disruption of the NE continuity in cells migrating through confined spaces, and uncover an essential role for the Endosomal Sorting Complex Required for Transport (ESCRT) machinery in the resealing of these nuclear discontinuities. PMID:27151367

  3. Command and control in new nuclear states: Implications for stability. Master's thesis

    SciTech Connect

    Foley, D.C.

    1994-06-01

    Command and control systems of new nuclear states are likely to fail when placed under stress. This thesis will demonstrate that such failures can dramatically affect regional or international stability. Describing the current argument over the consequences of nuclear proliferation between proliferation pessimists and deterrence optimists, this thesis shows how C2 is in fact the crux of the debate. This thesis develops an analytical tool that may be applied to new nuclear states in order to classify their C2 systems and to predict when and how these evolving systems might fail. To show the tool's usefulness, it is applied to Ukraine, an important new nuclear state. This thesis also suggests several implications for U.S. foreign policy. Nuclear weapons, Command and control, Proliferation, Arms control, Regional stability, Russia, United States, Ukraine, Nuclear capabilities, U.S. Security policy.

  4. Demonstration of open-quantum-system optimal control in dynamic nuclear polarization

    NASA Astrophysics Data System (ADS)

    Sheldon, S.; Cory, D. G.

    2015-10-01

    Dynamic nuclear polarization (DNP) is used in nuclear magnetic resonance to transfer polarization from electron spins to nuclear spins. The resulting nuclear polarization enhancement can, in theory, be two or three orders of magnitude depending on the sample. In solid-state systems, however, there are competing mechanisms of DNP, which, when occurring simultaneously, reduce the net polarization enhancement of the nuclear spin. We present a simple quantum description of DNP and apply optimal control theory (OCT) with an open-quantum-system framework to design pulses that select one DNP process and suppress the others. We demonstrate experimentally an order of magnitude improvement in the DNP enhancement using OCT pulses.

  5. Nuclear Non-Proliferation Act of 1978: origins, contradictions, and implications for control of peaceful nuclear activities

    SciTech Connect

    Beckman, R.L.

    1984-01-01

    The US Congress has written stringent nonproliferation legislation that attempts to tighten US nuclear export criteria and strengthen the international nonproliferation regime. NNPA/78 created worldwide controversy because of its unilateral nature, and assertations by Congress that commercial reprocessing, plutonium, and breeder reactors are inherently dangerous. Nonetheless, efforts continue in Congress to close loopholes in nonproliferation law and to prevent commercial trafficking in explosives-grade material. This paper chronicles the history of those efforts, using extensive interviews with members of the nuclear priesthood and with nuclear reformers seeking to reorient energy policy and to prevent the second nuclear era from repeating the alleged mistakes of the first. Beginning with the Acheson-Lilienthal Report, and moving through both military and commercial nuclear history, the study highlights critical shifts in thought on nuclear dangers: Atoms for Peace, arms control efforts, the NPT, the National Environmental Policy Act, the Energy Reorganization Act, energy crises, the Indian explosion, and crucial legislative roles played by antinuclear activists and zealous congressional staff members. Extensive attention is paid to shifts in philosophical orientations in Congress about nuclear power, and to the growing distrust of the AEC, the JCAE, and the IAEA safeguards regime.

  6. Electromagnetic Signature Technique as a Promising Tool to Verify Nuclear Weapons Storage and Dismantlement under a Nuclear Arms Control Regime

    SciTech Connect

    Bunch, Kyle J.; Williams, Laura S.; Jones, Anthony M.; Ramuhalli, Pradeep

    2012-08-01

    The 2010 ratification of the New START Treaty has been widely regarded as a noteworthy national security achievement for both the Obama administration and the Medvedev-Putin regime, but deeper cuts are envisioned under future arms control regimes. Future verification needs will include monitoring the storage of warhead components and fissile materials and verifying dismantlement of warheads, pits, secondaries, and other materials. From both the diplomatic and technical perspectives, verification under future arms control regimes will pose new challenges. Since acceptable verification technology must protect sensitive design information and attributes, non-nuclear non-sensitive signatures may provide a significant verification tool without the use of additional information barriers. The use of electromagnetic signatures to monitor nuclear material storage containers is a promising technology with the potential to fulfill these challenging requirements. Research performed at Pacific Northwest National Laboratory (PNNL) has demonstrated that low frequency electromagnetic signatures of sealed metallic containers can be used to confirm the presence of specific components on a “yes/no” basis without revealing classified information. Arms control inspectors might use this technique to verify the presence or absence of monitored items, including both nuclear and non-nuclear materials. Although additional research is needed to study signature aspects such as uniqueness and investigate container-specific scenarios, the technique potentially offers a rapid and cost-effective tool to verify reduction and dismantlement of U.S. and Russian nuclear weapons.

  7. Calvarium and dura mater as delayed sites of distant metastasis from papillary thyroid carcinoma

    PubMed Central

    AL-Qahtani, Khalid Hussain; Tunio, Mutahir A; Al Asiri, Mushabbab; Fatani, Hanadi; Bayoumi, Yasser

    2015-01-01

    Background Skull calvarium and dura mater are rare sites of distant metastasis, and mostly have been reported in lung, breast, and prostate malignancies. However, the calvarial and dural metastases from papillary thyroid cancer (PTC) are rare entities and pose diagnostic and therapeutic challenges. To date, only seven cases of calvarial metastasis with intracranial extension from PTC have been reported in literature. However, true dural metastasis from PTC has not yet been reported. Case presentation A 65-year-old Saudi woman presented with 6 months history of painful posterior scalp lump, 7 years after initial diagnosis of PTC. Computed tomography and magnetic resonance imaging showed occipitoparietal calvarial lesion with massive intracranial extension. Another para-sagittal lesion was found at the top of corpus callosum mimicking a meningioma. Histopathology of para-sagittal lesion and the biopsy of calvarial mass confirmed the diagnosis of metastatic PTC. After surgical resection, residual tumors were treated with postoperative intensity-modulated radiation therapy. At 13 months of follow-up, patient was alive and without any signs of recurrence. Conclusion Calvarial and dural metastases from PTC are extremely rare clinical entities. Surgical resection followed by postoperative radiotherapy is the treatment of choice. However, for such cases, multidisciplinary approach can prolong the treatment outcome and survival. PMID:26527901

  8. Cohort Profile Update: The Mater-University of Queensland Study of Pregnancy (MUSP).

    PubMed

    Najman, Jake M; Alati, Rosa; Bor, William; Clavarino, Alexandra; Mamun, Abdullah; McGrath, John J; McIntyre, David; O'Callaghan, Michael; Scott, James; Shuttlewood, Greg; Williams, Gail M; Wray, Naomi

    2015-02-01

    The Mater-University of Queensland Study of Pregnancy (MUSP) and its outcomes began in 1981 with data collected on 7223 pregnant woman-child pairs (6753 mothers, of whom 520 had 2 study children, less 50 who had multiple births). These women, and their children, were initially followed for up to 21 years. Since then there have been additional follow-ups of the mothers (27 years) and their children (30 years). There has also been a substantial increase in the breadth of topics addressed, with the collection of biological samples, the administration of structured clinical assessments of mental health and cognitive capacity, and markers of physical health such as lung function and blood pressure. MUSP was originally developed as a birth cohort study. It has become a longitudinal study of growth, development and ageing with an emphasis on the generational transmission of a wide range of factors impacting on adult health outcomes. We welcome interest in our study; for study background and publications visit [www.socialscience.uq.edu.au/musp] or contact [j.najman@uq.edu.au]. PMID:25519422

  9. Vertical osteoconductivity of sputtered hydroxyapatite-coated mini titanium implants after dura mater elevation: Rabbit calvarial model

    PubMed Central

    Zakaria, Osama; Madi, Marwa; Kasugai, Shohei

    2015-01-01

    This study evaluated the quantity and quality of newly formed vertical bone induced by sputtered hydroxyapatite-coated titanium implants compared with sandblasted acid-etched implants after dura mater elevation. Hydroxyapatite-coated and non-coated implants (n = 20/group) were used and divided equally into two groups. All implants were randomly placed into rabbit calvarial bone (four implants for each animal) emerging from the inferior cortical layer, displacing the dura mater 3 mm below the original bone. Animals were sacrificed at 4 (n = 5) and 8 (n = 5) weeks post-surgery. Vertical bone height and area were analyzed histologically and radiographically below the original bone. Vertical bone formation was observed in both groups. At 4 and 8 weeks, vertical bone height reached a significantly higher level in the hydroxyapatite compared with the non-coated group (p < 0.05). Vertical bone area was significantly larger in the hydroxyapatite compared with the non-coated group at 4 and 8 weeks (p < 0.05). This study indicates that vertical bone formation can be induced by dura mater elevation and sputtered hydroxyapatite coating can enhance vertical bone formation. PMID:26977283

  10. Feedback control of nuclear spin bath of a single hole spin in a quantum dot

    NASA Astrophysics Data System (ADS)

    Pang, Hongliang; Gong, Zhirui; Yao, Wang

    2015-01-01

    For a III-V semiconductor quantum dot charged with a single hole, we investigate the feedback control of the nuclear spin bath through dynamical nuclear spin polarization. The scheme utilizes the hole-nuclear flip-flop by their anisotropic hyperfine interaction, where the flip direction of the nuclear spin can be conditioned on the sign of the overall hyperfine field through initialization processes that do not involve explicit measurement. We show that a negative feedback can be implemented to suppress the statistical fluctuations of the nuclear hyperfine field for enhancing the coherence time of the hole spin qubit. Positive feedback can prepare the nuclear spin ensemble into states where the nuclear hyperfine field distribution has two well separated peaks, realizing a quantum heat bath that cannot be described by a single effective temperature.

  11. Nuclear instrumentation, process instrumentation and control, and engineered safety features. Volume nine

    SciTech Connect

    Not Available

    1986-01-01

    Volume nine covers nuclear instrumentation (detection of nuclear radiation, gas-filled detectors, measuring neutron population, BWR/PWR nuclear instrumentation), process instrumentation and control (what is process instrumentation, pressure detectors and transducers, temperature detectors and transducers, level detectors and transducers, flow detectors and transducers, mechanical position detectors and transducers, what are the major processes controlled, BWR and PWR process instrumentation and control), engineered safety features (why are engineered safety features provided, the design basis accident, engineered safety feature operation, PWR engineered safety feature systems, BWR engineered safety feature systems).

  12. Nuclear Nonproliferation and Arms Control Primer Prepared for the Blue Ribbon Commission on America’s Nuclear Future

    SciTech Connect

    Williams, Laura S.

    2011-05-25

    To provide a brief overview of key arms control and nonproliferation arrangements for the layperson that may be relevant to the Commission's comprehensive review of policies for managing the back end of the nuclear fuel cycle. Primer would be published by the Commission and made publicly available, probably as an appendix to a larger Commission report.

  13. Routine Quality Control of Clinical Nuclear Medicine Instrumentation: A Brief Review*

    PubMed Central

    Zanzonico, Pat

    2009-01-01

    This article reviews routine quality-control (QC) procedures for current nuclear medicine instrumentation, including the survey meter, dose calibrator, well counter, intraoperative probe, organ (“thyroid”) uptake probe, γ-camera, SPECT and SPECT/CT scanner, and PET and PET/CT scanner. It should be particularly useful for residents, fellows, and other trainees in nuclear medicine, nuclear cardiology, and radiology. The procedures described and their respective frequencies are presented only as general guidelines. PMID:18587088

  14. Establishment of a national program for quality control of nuclear medicine instrumentation.

    PubMed

    Coca Perez, Marco A; Torres Aroche, Leonel A; Bejerano, Gladys López; Mayor, Roberto Fraxedas; Corona, Consuelo Varela; López, Adlin

    2008-12-01

    Monitoring the quality of instrumentation used in nuclear medicine is mandatory to guarantee the clinical efficacy of medical practice. A national program for the quality control of nuclear medicine instruments was established in Cuba and was certified and approved by the regulatory authorities. The program, which establishes official regulations and audit services, sets up educational activities, distributes technical documentation, and maintains a national phantom bank, constitutes a valuable and useful tool to guarantee the quality of nuclear medicine instrumentation. PMID:19008290

  15. A treaty to ban nuclear smuggling: The next step in nuclear material control?

    SciTech Connect

    Carnahan, B.M.; Smith, J.R.

    1994-10-01

    Since the demise of the Soviet Union, reports have continued to surface that weapons-usable nuclear material has been smuggled out of former Soviet territory into the hands of proliferant states. So far, few examples of nuclear smuggling have involved serious quantities of weapons-usable material, and much purported smuggling has involved attempted fraud rather than an effort to transfer fissile material. In no instance has an actual transfer to a potential proliferant state been verified.

  16. 10 CFR 50.44 - Combustible gas control for nuclear power reactors.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Combustible gas control for nuclear power reactors. 50.44 Section 50.44 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION... environmental conditions created by the burning of hydrogen. Environmental conditions caused by...

  17. A rhomboid gene controls speciation through regulation of nuclear-mitochondrial compatibility in Triticum

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The nuclear encoded species cytoplasm specific (scs) genes control nuclear-cytoplasmic compatibility in Triticum. Alloplasmic cells, which have nucleus and cytoplasm derived from different species, produce vigorous and vital organisms only when the correct version of scs is present in their nucleus....

  18. Controlling the Proliferation of Nuclear Weapons: Study Guide for Teachers and Students

    ERIC Educational Resources Information Center

    United States Institute of Peace, 2005

    2005-01-01

    The objectives of this teaching guide are: (1) to increase student understanding of the prevalence and spread of nuclear weapons; (2) to familiarize students with historic and contemporary measures to control nuclear proliferation and stimulate their thinking of potential strategies for doing so in the future; (3) to develop students' analytical…

  19. 22 CFR 123.20 - Nuclear related controls.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of Energy or the Nuclear Regulatory Commission pursuant to the Atomic Energy Act of 1954, as amended... thereof is prohibited except as authorized by the Atomic Energy Act of 1954, as amended. The transfer of Restricted Data or such assistance is prohibited except as authorized by the Atomic Energy Act of 1954,...

  20. Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity.

    PubMed

    Schmidt, Karyn; Butler, J Scott

    2013-01-01

    The advent of high-throughput sequencing technologies has revealed that pervasive transcription generates RNAs from nearly all regions of eukaryotic genomes. Normally, these transcripts undergo rapid degradation by a nuclear RNA surveillance system primarily featuring the RNA exosome. This multimeric protein complex plays a critical role in the efficient turnover and processing of a vast array of RNAs in the nucleus. Despite its initial discovery over a decade ago, important questions remain concerning the mechanisms that recruit and activate the nuclear exosome. Specificity and modulation of exosome activity requires additional protein cofactors, including the conserved TRAMP polyadenylation complex. Recent studies suggest that helicase and RNA-binding subunits of TRAMP direct RNA substrates for polyadenylation, which enhances their degradation by Dis3/Rrp44 and Rrp6, the two exosome-associated ribonucleases. These findings indicate that the exosome and TRAMP have evolved highly flexible functions that allow recognition of a wide range of RNA substrates. This flexibility provides the nuclear RNA surveillance system with the ability to regulate the levels of a broad range of coding and noncoding RNAs, which results in profound effects on gene expression, cellular development, gene silencing, and heterochromatin formation. This review summarizes recent findings on the nuclear RNA surveillance complexes, and speculates upon possible mechanisms for TRAMP-mediated substrate recognition and exosome activation. PMID:23417976

  1. 22 CFR 123.20 - Nuclear related controls.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of Energy or the Nuclear Regulatory Commission pursuant to the Atomic Energy Act of 1954, as amended... thereof is prohibited except as authorized by the Atomic Energy Act of 1954, as amended. The transfer of Restricted Data or such assistance is prohibited except as authorized by the Atomic Energy Act of 1954,...

  2. Control of electron spin decoherence caused by electron nuclear spin dynamics in a quantum dot

    NASA Astrophysics Data System (ADS)

    Liu, Ren-Bao; Yao, Wang; Sham, L. J.

    2007-07-01

    Control of electron spin decoherence in contact with a mesoscopic bath of many interacting nuclear spins in an InAs quantum dot is studied by solving the coupled quantum dynamics. The nuclear spin bath, because of its bifurcated evolution predicated on the electron spin up or down state, measures the which-state information of the electron spin and hence diminishes its coherence. The many-body dynamics of the nuclear spin bath is solved with a pair-correlation approximation. In the relevant timescale, nuclear pair-wise flip flops, as elementary excitations in the mesoscopic bath, can be mapped into the precession of non-interacting pseudo-spins. Such mapping provides a geometrical picture for understanding the decoherence and for devising control schemes. A close examination of nuclear bath dynamics reveals a wealth of phenomena and new possibilities of controlling the electron spin decoherence. For example, when the electron spin is flipped by a π-pulse at τ, its coherence will partially recover at \\sqrt{2}\\tau as a consequence of quantum disentanglement from the mesoscopic bath. In contrast to the re-focusing of inhomogeneously broadened phases by conventional spin-echoes, the disentanglement is realized through shepherding quantum evolution of the bath state via control of the quantum object. A concatenated construction of pulse sequences can eliminate the decoherence with arbitrary accuracy, with the nuclear nuclear spin interaction strength acting as the controlling small parameter.

  3. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Subject areas eligible to be Unclassified Controlled Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION... the Atomic Energy Act....

  4. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Subject areas eligible to be Unclassified Controlled Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION... the Atomic Energy Act....

  5. 10 CFR 1017.8 - Subject areas eligible to be Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Subject areas eligible to be Unclassified Controlled Nuclear Information. 1017.8 Section 1017.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION... the Atomic Energy Act....

  6. Lessons from UNSCOM/IAEA applicable to nuclear arms control

    SciTech Connect

    Dorn, D.W.

    1995-12-05

    In early 1991, the Security Council of the United Nations tasked the Director General of the International Atomic Energy Agency, with the assistance and cooperation of the United Nations Special Commission, to oversee the destruction, removal or rendering harmless of nuclear weapons material and capabilities in Iraq. The conduct of the nuclear inspections, and the subsequent activities (identification, destruction, removal rendering harmless), have provided a wealth of experience and insight into the inspection and monitoring process as well as into the political realities of such an operation. The early inspections were conducted in an atmosphere of discovery and inexperience on both the part of the Iraqis and the IAEA and UNSCOM. As time went on, the Iraqis became more adept at hiding and obscuring relevant documents and equipment, and the inspection teams became more knowledgeable about inspection and investigative techniques, and the pre-existing Iraqi programs. A continuous monitoring presence in Iraq has now been established and an import/export monitoring regime is being developed. While steps taken to date have proven effective in inhibiting resumption of nuclear weaponization activities, it remains to be seen how effective these measures will be in the future. The external and internal conditions which led the Iraqi leadership to undertake a nuclear weaponization program have not changed, and the prognosis for the long term is uncertain. The entire process in Iraq has shown how fragile are the tools available to the international community, and how a determined proliferator can evade inspection and monitoring measures. Such measures cannot prevent nuclear proliferation, they can only hope to deter it, or, failing in that, detect it.

  7. ACCELERATED TESTING OF NEUTRON-ABSORBING ALLOYS FOR NUCLEAR CRITICALITY CONTROL

    SciTech Connect

    Ronald E. Mizia

    2011-10-01

    The US Department of Energy requires nuclear criticality control materials be used for storage of highly enriched spent nuclear fuel used in government programs and the storage of commercial spent nuclear fuel at the proposed High-Level Nuclear Waste Geological Repository located at Yucca Mountain, Nevada. Two different metallic alloys (Ni-Cr-Mo-Gd and borated stainless steel) have been chosen for this service. An accelerated corrosion test program to validate these materials for this application is described and a performance comparison is made.

  8. Detection and Control of Individual Nuclear Spins Using a Weakly Coupled Electron Spin

    SciTech Connect

    Taminiau, T.H.; Wagenaar, J.J.T.; van der Sar, T.; Jelezko, F.; Dobrovitski, Viatcheslav V.; Hanson, R.

    2012-09-28

    We experimentally isolate, characterize, and coherently control up to six individual nuclear spins that are weakly coupled to an electron spin in diamond. Our method employs multipulse sequences on the electron spin that resonantly amplify the interaction with a selected nuclear spin and at the same time dynamically suppress decoherence caused by the rest of the spin bath. We are able to address nuclear spins with interaction strengths that are an order of magnitude smaller than the electron spin dephasing rate. Our results provide a route towards tomography with single-nuclear-spin sensitivity and greatly extend the number of available quantum bits for quantum information processing in diamond.

  9. Update: Creutzfeldt-Jakob disease associated with cadaveric dura mater grafts--Japan, 1978-2008.

    PubMed

    2008-10-24

    Creutzfeldt-Jakob disease (CJD) is the most common of the human prion diseases (also known as transmissible spongiform encephalopathies), which, according to the leading hypothesis, are caused by an abnormal protein (i.e., prion) that is able to induce abnormal folding of normal cellular prion proteins. Annual worldwide incidence of these always fatal neurodegenerative diseases is estimated at 0.5-2.0 cases per million population. CJD can occur sporadically, or as a genetic disease, or can be transmitted iatrogenically. In 1996, a new human prion disease, variant CJD (vCJD), was first described in the United Kingdom. This disease was believed to have resulted from human consumption of cattle products contaminated with the prions responsible for bovine spongiform encephalopathy (BSE, commonly known as mad cow disease). That year, in part to check for possible vCJD cases, a national survey was conducted in Japan; 821 CJD cases were identified, including 43 cases associated with receipt of cadaveric dura mater grafts. A single brand of dural graft (Lyodura) produced by a German manufacturer before May 1987 was identified as the most likely vehicle of transmission in all but one case. By 2003, continued surveillance in Japan had identified a total of 97 such cases. Since then, an additional 35 cases have been identified. This report updates previous reports and summarizes the investigation of all 132 cases to date linked to dural grafts. The results suggest that, because of the long incubation period between graft receipt and symptom onset (possibly >24.8 years), continued surveillance in Japan might identify additional CJD cases associated with dural grafts. PMID:18946463

  10. TRANSPARENCY, VERIFICATION AND THE FUTURE OF NUCLEAR NONPROLIFERATION AND ARMS CONTROL

    SciTech Connect

    J. PILAT

    2000-11-01

    In the future, if the nuclear nonproliferation and arms control agendas are to advance, they will likely become increasingly seen as parallel undertakings with the objective of cradle-to-grave controls over nuclear warheads and/or materials. The pursuit of such an agenda was difficult enough at the outset of the nuclear age; it will be more difficult in the future with relatively wide-spread military and civil nuclear programs. This agenda will require both verification and transparency. To address emerging nuclear dangers, we may expect hybrid verification-transparency regimes to be seen as acceptable. Such regimes would have intrusive but much more limited verification provisions than Cold War accords, and have extensive transparency provisions designed in part to augment the verification measures, to fill in the ''gaps'' of the verification regime, and the like.

  11. Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

    PubMed Central

    Luo, C; Shaw, K T; Raghavan, A; Aramburu, J; Garcia-Cozar, F; Perrino, B A; Hogan, P G; Rao, A

    1996-01-01

    The nuclear import of the nuclear factor of activated T cells (NFAT)-family transcription factors is initiated by the protein phosphatase calcineurin. Here we identify a regulatory region of NFAT1, N terminal to the DNA-binding domain, that controls nuclear import of NFAT1. The regulatory region of NFAT1 binds directly to calcineurin, is a substrate for calcineurin in vitro, and shows regulated subcellular localization identical to that of full-length NFAT1. The corresponding region of NFATc likewise binds calcineurin, suggesting that the efficient activation of NFAT1 and NFATc by calcineurin reflects a specific targeting of the phosphatase to these proteins. The presence in other NFAT-family transcription factors of several sequence motifs from the regulatory region of NFAT1, including its probable nuclear localization sequence, indicates that a conserved protein domain may control nuclear import of all NFAT proteins. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:8799126

  12. Nuclear receptors linking circadian rhythms and cardiometabolic control

    PubMed Central

    Duez, Hélène; Staels, Bart

    2010-01-01

    Many behavioral and physiological processes, including locomotor activity, blood pressure, body temperature, sleep(fasting)/wake(feeding) cycles as well as metabolic regulation display diurnal rhythms. The biological clock ensures proper metabolic alignment of energy substrate availability and processing. Studies in animals and humans highlight a strong link between circadian disorders and altered metabolic responses and cardiovascular events. Shiftwork, for instance, increases the risk to develop metabolic abnormalities resembling the Metabolic Syndrome. Nuclear receptors have long been known as metabolic regulators. Several of them (ie. Rev-erbα, RORα, PPARs) are subjected to circadian variations and are integral components of the molecular clock machinery. In turn, these nuclear receptors regulate downstream target genes in a circadian manner, acting to properly gate metabolic events to the appropriate circadian time window. PMID:20631353

  13. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.

    PubMed

    Sieber, Matthew H; Thummel, Carl S

    2009-12-01

    Triacylglycerol (TAG) homeostasis is an integral part of normal physiology and essential for proper energy metabolism. Here we show that the single Drosophila ortholog of the PXR and CAR nuclear receptors, DHR96, plays an essential role in TAG homeostasis. DHR96 mutants are sensitive to starvation, have reduced levels of TAG in the fat body and midgut, and are resistant to diet-induced obesity, while DHR96 overexpression leads to starvation resistance and increased TAG levels. We show that DHR96 function is required in the midgut for the breakdown of dietary fat and that it exerts this effect through the CG5932 gastric lipase, which is essential for TAG homeostasis. This study provides insights into the regulation of dietary fat metabolism in Drosophila and demonstrates that the regulation of lipid metabolism is an ancestral function of the PXR/CAR/DHR96 nuclear receptor subfamily. PMID:19945405

  14. Method and apparatus for monitoring the control rods of a nuclear reactor

    SciTech Connect

    Gravelle, A.; Marini, J.; Romy, D.

    1984-12-04

    Method and apparatus for monitoring the movement of the control rods of a nuclear reactor. The number of steps of movement in either direction of the rod from which the control rod is suspended is counted. According to the height of the step, an indication of the position of the suspension rod and of the control rod. The apparatus comprises devices for measuring the speed of movement of the control rod, for logging variations in speed higher than a given value, and for counting such variations according to their sign. The invention is particularly useful in pressurized water nuclear reactors.

  15. Who Should Control Nuclear Technology? A Curriculum Unit for Contemporary U.S. and World History, Grades 9-12.

    ERIC Educational Resources Information Center

    Zimney, Michelle; Boston, Jane

    Since the end of World War II and the onset of the "new age," nuclear technology has remained high on the world's agenda as questions regarding sovereignty and the balance of power, control of the development and spread of nuclear weapons, non-military uses for nuclear technology, and nuclear safety are debated among and within nations. The "club"…

  16. WTEC panel report on European nuclear instrumentation and controls. Final report

    SciTech Connect

    White, J.D.; Lanning, D.D.; Beltracchi, L.; Best, F.R.; Easter, J.R.

    1991-12-01

    A study of instrumentation and controls (I and C) technology used in nuclear power plants in Europe was conducted by a panel of American specialists. The study included a review of the literature on the subject, followed by a visit to some of the leading organizations in Europe in the field of nuclear I and C. The findings of the study are presented in the report. The scope is limited to pressurized water reactors in Czechoslovakia, France, Germany, Norway and Russia. Specific topics include: The role of the operator and control room design; the transition from analog to digital technology; computerized operator support systems for fault management; control strategies and techniques; an investigation of nuclear power plant I and C architecture; instrumentation; computer standards and tools. A companion study is JTEC Panel Report on Nuclear Power in Japan (PB90-215724).

  17. Overview of implementing a project control system in the nuclear utility industry

    SciTech Connect

    Cooprider, D.H. )

    1994-03-01

    During the late 1980s, a metamorphosis began at Florida Power and Light Company (FPL). A strategic step in nuclear engineering's efforts to become more cost effective began in January 1990. A project control department was formed. The initial mission was to provide support for nuclear engineering design activities associated with FPL's two twin-unit nuclear power generation facilities - Turkey Point and St. Lucie. Later, the goal expanded to include the division's materials management, nuclear licensing, and information management departments. The project control group was organized along the lines of the organizations served. Separate dedicated groups were established for each plant. Since most engineering activity was based at the Juno Beach headquarters, the project control staff also was based there.

  18. OVERVIEW OF A RECONFIGURABLE SIMULATOR FOR MAIN CONTROL ROOM UPGRADES IN NUCLEAR POWER PLANTS

    SciTech Connect

    Ronald L. Boring

    2012-10-01

    This paper provides background on a reconfigurable control room simulator for nuclear power plants. The main control rooms in current nuclear power plants feature analog technology that is growing obsolete. The need to upgrade control rooms serves the practical need of maintainability as well as the opportunity to implement newer digital technologies with added functionality. There currently exists no dedicated research simulator for use in human factors design and evaluation activities for nuclear power plant modernization in the U.S. The new research simulator discussed in this paper provides a test bed in which operator performance on new control room concepts can be benchmarked against existing control rooms and in which new technologies can be validated for safety and usability prior to deployment.

  19. Startup control of the TOPAZ-II space nuclear reactor. Master`s thesis

    SciTech Connect

    Astrin, C.D.

    1996-09-01

    The Russian designed and manufactured TOPAZ-II Thermionic Nuclear Space Reactor has been supplied to the Ballistic Missile Defense Organization for study as part of the TOPAZ International Program. A Preliminary Nuclear Safety Assessment investigated the readiness to use the TOPAZ-II in support of a Nuclear Electric Propulsion Space Test Mission (NEPSTP). Among the anticipated system modifications required for launching the TOPAZ-II system within safety goals is for a U.S. designed Automatic Control System. The requirements and desired features of such a control system are developed based upon U.S. safety standards. System theory and design are presented in order to establish the basis for development of a hybrid control model from available simulations. The model is verified and then used in exploration of various control schemes and casualty analysis providing groundwork for future Automatic Control System design.

  20. Optogenetic Control of Nuclear Protein Import in Living Cells Using Light-Inducible Nuclear Localization Signals (LINuS).

    PubMed

    Wehler, Pierre; Niopek, Dominik; Eils, Roland; Di Ventura, Barbara

    2016-01-01

    Many biological processes are regulated by the timely import of specific proteins into the nucleus. The ability to spatiotemporally control the nuclear import of proteins of interest therefore allows study of their role in a given biological process as well as controlling this process in space and time. The light-inducible nuclear localization signal (LINuS) was developed based on a natural plant photoreceptor that reversibly triggers the import of proteins of interest into the nucleus with blue light. Each LINuS is a small, genetically encoded domain that is fused to the protein of interest at the N or C terminus. These protocols describe how to carry out initial microscopy-based screening to assess which LINuS variant works best with a protein of interest. © 2016 by John Wiley & Sons, Inc. PMID:27258691

  1. CONTROL ROD DRIVE MECHANISM FOR A NUCLEAR REACTOR

    DOEpatents

    Hawke, B.C.; Liederbach, F.J.; Lones, W.

    1963-05-14

    A lead-screw-type control rod drive featuring an electric motor and a fluid motor arranged to provide a selectably alternative driving means is described. The electric motor serves to drive the control rod slowly during normal operation, while the fluid motor, assisted by an automatic declutching of the electric motor, affords high-speed rod insertion during a scram. (AEC)

  2. The Control of the PBMR Nuclear Power Unit

    SciTech Connect

    Rubin, Olis; Venter, Miek; Jordaan, Johannes

    2006-07-01

    PBMR is an advanced, helium-cooled, graphite-moderated High Temperature Gas-cooled Reactor (HTGR). Heat is converted to electric energy by means of a direct recuperative Brayton cycle. This paper considers various design aspects associated with the control of the unit and examples are given of generator load control. Physical material restrictions and process dynamics have a major effect on control, necessitating detail thermo-hydraulic simulation of the plant operation. The Flownex dynamic thermo-hydraulic simulation code was developed to model the plant, which is linked to the control software for co-simulation. Matlab and Simulink are used for controller development while care was taken to ensure compatibility with the operational control code based on IEC standards. Generator load is controlled by regulating the helium inventory in the pressurized system. Helium is injected in order to increase the generator load, and extracted for load reduction. While this method of actuation produces the required steady state response, the plant dynamic response is non minimum phase, i.e. the load initially reduces on a load ramp-up. In base load operation, the extent of the power dip is contained by limiting the rate at which the helium injection can be increased. Feasibility studies show that it is possible to achieve faster load ramp rates by combining helium injection with quick response cycle gas bypass control. Lead compensation on the input load reference signal further enhances the load following capabilities of the unit. (authors)

  3. Laser bonding with ICG-infused chitosan patches: preliminary experiences in suine dura mater and vocal folds

    NASA Astrophysics Data System (ADS)

    Rossi, Francesca; Matteini, Paolo; Ratto, Fulvio; Pini, Roberto; Iacoangeli, Maurizio; Giannoni, Luca; Fortuna, Damiano; Di Cicco, Emiliano; Corbara, Sylwia; Dallari, Stefano

    2014-05-01

    Laser bonding is a promising minimally invasive approach, emerging as a valid alternative to conventional suturing techniques. It shows widely demonstrated advantages in wound treatment: immediate closuring effect, minimal inflammatory response and scar formation, reduced healing time. This laser based technique can overcome the difficulties in working through narrow surgical corridors (e.g. the modern "key-hole" surgery as well as the endoscopy setting) or in thin tissues that are impossible to treat with staples and/or stitches. We recently proposed the use of chitosan matrices, stained with conventional chromophores, to be used in laser bonding of vascular tissue. In this work we propose the same procedure to perform laser bonding of vocal folds and dura mater repair. Laser bonding of vocal folds is proposed to avoid the development of adhesions (synechiae), after conventional or CO2 laser surgery. Laser bonding application in neurosurgery is proposed for the treatment of dural defects being the Cerebro Spinal Fluid leaks still a major issue. Vocal folds and dura mater were harvested from 9-months old porks and used in the experimental sessions within 4 hours after sacrifice. In vocal folds treatment, an IdocyanineGreen-infused chitosan patch was applied onto the anterior commissure, while the dura mater was previously incised and then bonded. A diode laser emitting at 810 nm, equipped with a 600 μm diameter optical fiber was used to weld the patch onto the tissue, by delivering single laser spots to induce local patch/tissue adhesion. The result is an immediate adhesion of the patch to the tissue. Standard histology was performed, in order to study the induced photothermal effect at the bonding sites. This preliminary experimental activity shows the advantages of the proposed technique in respect to standard surgery: simplification of the procedure; decreased foreign-body reaction; reduced inflammatory response; reduced operating times and better handling in

  4. Implementation of an Enhanced Measurement Control Program for handling nuclear safety samples at WSRC

    SciTech Connect

    Boler-Melton, C.; Holland, M.K.

    1991-01-01

    In the separation and purification of nuclear material, nuclear criticality safety (NCS) is of primary concern. The primary nuclear criticality safety controls utilized by the Savannah River Site (SRS) Separations Facilities involve administrative and process equipment controls. Additional assurance of NCS is obtained by identifying key process hold points where sampling is used to independently verify the effectiveness of production control. Nuclear safety measurements of samples from these key process locations provide a high degree of assurance that processing conditions are within administrative and procedural nuclear safety controls. An enhanced procedure management system aimed at making improvements in the quality, safety, and conduct of operation was implemented for Nuclear Safety Sample (NSS) receipt, analysis, and reporting. All procedures with nuclear safety implications were reviewed for accuracy and adequate detail to perform the analytical measurements safely, efficiently, and with the utmost quality. Laboratory personnel worked in a Deliberate Operating'' mode (a systematic process requiring continuous expert oversight during all phases of training, testing, and implementation) to initiate the upgrades. Thus, the effort to revise and review nuclear safety sample procedures involved a team comprised of a supervisor, chemist, and two technicians for each procedure. Each NSS procedure was upgraded to a Use Every Time'' (UET) procedure with sign-off steps to ensure compliance with each step for every nuclear safety sample analyzed. The upgrade program met and exceeded both the long and short term customer needs by improving measurement reliability, providing objective evidence of rigid adherence to program principles and requirements, and enhancing the system for independent verification of representative sampling from designated NCS points.

  5. Implementation of an Enhanced Measurement Control Program for handling nuclear safety samples at WSRC

    SciTech Connect

    Boler-Melton, C.; Holland, M.K.

    1991-12-31

    In the separation and purification of nuclear material, nuclear criticality safety (NCS) is of primary concern. The primary nuclear criticality safety controls utilized by the Savannah River Site (SRS) Separations Facilities involve administrative and process equipment controls. Additional assurance of NCS is obtained by identifying key process hold points where sampling is used to independently verify the effectiveness of production control. Nuclear safety measurements of samples from these key process locations provide a high degree of assurance that processing conditions are within administrative and procedural nuclear safety controls. An enhanced procedure management system aimed at making improvements in the quality, safety, and conduct of operation was implemented for Nuclear Safety Sample (NSS) receipt, analysis, and reporting. All procedures with nuclear safety implications were reviewed for accuracy and adequate detail to perform the analytical measurements safely, efficiently, and with the utmost quality. Laboratory personnel worked in a ``Deliberate Operating`` mode (a systematic process requiring continuous expert oversight during all phases of training, testing, and implementation) to initiate the upgrades. Thus, the effort to revise and review nuclear safety sample procedures involved a team comprised of a supervisor, chemist, and two technicians for each procedure. Each NSS procedure was upgraded to a ``Use Every Time`` (UET) procedure with sign-off steps to ensure compliance with each step for every nuclear safety sample analyzed. The upgrade program met and exceeded both the long and short term customer needs by improving measurement reliability, providing objective evidence of rigid adherence to program principles and requirements, and enhancing the system for independent verification of representative sampling from designated NCS points.

  6. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... radioactive material in effluents-nuclear power reactors. 50.34a Section 50.34a Energy NUCLEAR REGULATORY... objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a... equipment to be installed to maintain control over radioactive materials in gaseous and liquid...

  7. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... radioactive material in effluents-nuclear power reactors. 50.34a Section 50.34a Energy NUCLEAR REGULATORY... objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a... equipment to be installed to maintain control over radioactive materials in gaseous and liquid...

  8. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... radioactive material in effluents-nuclear power reactors. 50.34a Section 50.34a Energy NUCLEAR REGULATORY... objectives for equipment to control releases of radioactive material in effluents—nuclear power reactors. (a... equipment to be installed to maintain control over radioactive materials in gaseous and liquid...

  9. 10 CFR 74.33 - Nuclear material control and accounting for uranium enrichment facilities authorized to produce...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Nuclear material control and accounting for uranium enrichment facilities authorized to produce special nuclear material of low strategic significance. 74.33 Section 74.33 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF...

  10. Satellite Surveillance of Nuclear Plant, Assisting IAEA Control

    NASA Astrophysics Data System (ADS)

    Mileikowsky, Curt

    1997-01-01

    One of the great problems for world society today is what to do with the 100 000 tons of spent fuel — produced by 400 power reactors in over 30 nations — that contain 1000 tons of civilian plutonium and that will double in volume over the next 10 to 15 years. That future amount of civilian plutonium represents material for 400 000 nuclear bombs: simple ones, relatively easily made, ideal for terrorists, of the strength of 10-70% of the Hiroshima bomb. Because of this risk, spent fuel has to be safeguarded for 10 000 years. The most straightforward way to eliminate the need for safeguarding spent fuel would be to burn it. That could best be done with an accelerator-driven subcritical reactor, i.e. one that cannot function without the assistance of a 1-2.5 GeV proton accelerator supplying the lacking neutrons and which therefore makes for an extremely safe plant that cannot run amok (as Chernobyl did for example). 100 of such plant could burn all the plutonium produced by the 400 present-type reactors in the world and simultaneously produce profitable electric power. But such a scheme requires proof that the accelerators could not themselves be used for producing nuclear bomb material. That utterly important task for world society could be significantly supported by the new commercial high resolution observation satellites.

  11. Remote controlled tool systems for nuclear sites have subsea applications

    SciTech Connect

    Bath, B.; Yemington, C.; Kuhta, B.

    1995-10-01

    Remotely operated underwater tool systems designed to operate in Nuclear Fuel Storage Basins can be applied to deep water, subsea oilfield applications. Spent nuclear fuel rods re stored underwater in large indoor swimming pool-like facilities where the water cover shields the workers from the radiation. This paper describes three specialized tooling systems that were designed and built by Sonsub for work at the Department of Energy`s Hanford site. The Door Seal Tool removed an existing seal system, cleaned a 20 ft. tall, carbon steel, underwater hatch and installed a new stainless steel gasket surface with underwater epoxy. The Concrete Sampling Tool was built to take core samples from the vertical, concrete walls of the basins. The tool has three hydraulic drills with proprietary hollow core drill bits to cut and retrieve the concrete samples. The Rack Saw remotely attached itself to a structure, cut a variety of steel shapes and pipes, and retained the cut pieces for retrieval. All of these systems are remotely operated with onboard video cameras and debris collection systems. The methods and equipment proven in this application are available to refurbish sealing surfaces and to drill or sample concrete in offshore oil field applications.

  12. Nuclear materials control technology in the post-cold war world: Radiation-based methods and information management systems

    SciTech Connect

    Tape, J.W.; Eccleston, G.W.; Ensslin, N.; Markin, J.T.

    1993-06-01

    The end of the cold war is providing both opportunities and requirements for improving the control of nuclear materials around the world. The dismantlement of nuclear weapons and the growth of nuclear power, including the use of plutonium in light water reactors and breeder reactor programs, coupled with enhanced proliferation concerns, drive the need for improved nuclear materials control. We describe nuclear materials control and the role of technology in making controls more effective and efficient. The current use and anticipated development in selected radiation-based methods and related information management systems am described briefly.

  13. An intravital microscopy study of radiation-induced changes in permeability and leukocyte-endothelial cell interactions in the microvessels of the rat pia mater and cremaster muscle.

    PubMed

    Gaber, M Waleed; Yuan, Hong; Killmar, John T; Naimark, Michael D; Kiani, Mohammad F; Merchant, Thomas E

    2004-04-01

    Using intravital microscopy and a closed window method, we measured irradiation-induced changes in the vascular permeability and cell interactions in microcirculation networks of the rat pia mater; the same effects were monitored in the cremaster muscle as a control. The closed cranial window has many advantages, including long-term direct visualization of microcirculation. The method allows for repeated testing of the same vessel or network, thereby reducing variability. The method also allows for measurement of permeability changes and the accompanying leukocyte-endothelial cell interactions in the same network or vessel, which permits correlative studies of these phenomena. However, this method is not without challenges. The optical conditions are difficult, because the brain is three-dimensional and its parenchyma is more complex than the thinner, flatter peripheral tissues. To overcome this limitation, we performed a dynamic background subtraction. The background is dynamically related to vessel intensity, and changes in intensity were determined by eliminating the effects of neighboring and underlying vessels. We applied this method to studying the effects of ionizing radiation on the blood-brain barrier (BBB) permeability and cell interactions and the modulation of these effects by anti-ICAM-1 antibodies. Our results demonstrate that this method is sensitive to changes in these properties of the BBB. PMID:15063835

  14. An integrated system for managing multidisciplinary oceanographic data collected in the Mediterranean Sea during the basin-scale research project EU/MAST-MATER (1996 2000)

    NASA Astrophysics Data System (ADS)

    Maillard, C.; Balopoulos, E.; Giorgetti, A.; Fichaut, M.; Iona, A.; Larour, M.; Latrouite, A.; Manca, B.; Maudire, G.; Nicolas, P.; Sanchez-Cabeza, J.-A.

    2002-06-01

    An advanced computer and communication technology was used to develop an integrated system and software tools for managing a great diversity of oceanographic data collected in the Mediterranean Sea during 1996-2000. Data were obtained during 108 sea cruises, carried out within the framework of the large-scale international research project MATER (mass transfer and ecosystem response), which was financially supported by the Marine Science and Technology (MAST) Programme of the European Union (EU). Data collection involved the active participation of various research vessels and personnel coming from 58 different laboratories of 13 countries. Data formatting as well as automatic and visual data quality controls were implemented using internationally accepted standards and procedures. Various data inventories and meta-data information, accessible through the World Wide Web (WWW), are made available to the user community. A database was developed, which, along with meta-data and other data relevant to the project information, is made available to the user community in the form of a CD-ROM. The database consists of 5861 vertical profiles and 842 time series of basic physical and biogeochemical parameters collected in the seawater column as well as biogeochemical parameters from the analysis of 70 sediment cores. Furthermore, it includes 67 cruise data files of nonstandard additional biological and atmospheric parameters.

  15. Beyond integrated safeguards: performance-based assessments for future nuclear controls.

    SciTech Connect

    Pilat, Joseph F.; Budlong-Sylvester, K. W.

    2001-01-01

    In the future, iE the nuclear nonproliferation and arms control agendas are to advance, they will likely become increasingly seen as parallel undertakings with the objective of comprehensive cradle-to-grave controls over nuclear materials and possibly even warheads removed from defense programs along with materials in civilian use. This 'back to the future' prospect was envisioned in the Acheson-Lillienthal Report and the Baruch Plan, and more modestly in the Atoms-for-Peace Proposal. Unlike the grand plans of the early nuclear years, today's and tomorrow's undertakings will more likely consist of a series of incremental steps with the goal of expanding nuclear controls. These steps will be undertaken at a time of fundamental change in the IAEA safeguards system, and they will be influenced by those changes in profound ways. This prospective influence needs to be taken into account as the IAEA develops and implements integrated safeguards, including its efforts to establish new safeguards criteria, undertake technological and administrative improvements in safeguards, implement credible capabilities for the detection of undeclared nuclear facilities and activities and, perhaps, provide for a more intensive involvement in applying safeguards in new roles such as the verification of a fissile materials cutoff treaty. Performance-based criteria offer one promising way to address the effectiveness of integrated safeguards and to provide a common means of assessing the other key areas of a comprehensive approach to nuclear controls as these develop independently and to the extent that they are coordinated in the future.

  16. 5 CFR 842.405 - Air traffic controllers, firefighters, law enforcement officers, and nuclear materials couriers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Air traffic controllers, firefighters... RETIREMENT SYSTEM-BASIC ANNUITY Computations § 842.405 Air traffic controllers, firefighters, law enforcement... or a law enforcement officer, firefighter or nuclear materials courier retiring under § 842.208...

  17. Multi-Canister overpack pressurization monitoring and control methodology for the spent nuclear fuel project

    SciTech Connect

    Pajunen, A.L., Westinghouse Hanford

    1996-07-19

    A control methodology is developed and monitoring alternatives evaluated for controlling pressurization in a Multi- Canister Overpack for the Hanford Spent Nuclear Fuel Project. Monitoring alternative evaluations include concept description, identification of uncertainties, and identification of experimental work required for implementation. A monitoring alternative is recommended and implementation requirements, risks and start up testing associated with the recommendation are discussed.

  18. Man/machine interface for a nuclear cask remote handling control station: system design requirements

    SciTech Connect

    Clarke, M.M.; Kreifeldt, J.G.; Draper, J.V.

    1984-07-09

    Design requirements are presented for a control station of a proposed semi-automated facility for remote handling of nuclear waste casks. Functional and operational man/machine interface: controls, displays, software format, station architecture, and work environment. In addition, some input is given to the design of remote sensing systems in the cask handling areas. 18 references, 9 figures, 12 tables.

  19. Near-term improvements for nuclear power plant control room annunciator systems. [PWR; BWR

    SciTech Connect

    Rankin, W.L.; Duvernoy, E.G.; Ames, K.R.; Morgenstern, M.H.; Eckenrode, R.J.

    1983-04-01

    This report sets forth a basic design philosophy with its associated functional criteria and design principles for present-day, hard-wired annunciator systems in the control rooms of nuclear power plants. It also presents a variety of annunciator design features that are either necessary for or useful to the implementation of the design philosophy. The information contained in this report is synthesized from an extensive literature review, from inspection and analysis of control room annunciator systems in the nuclear industry and in related industries, and from discussions with a variety of individuals who are knowledgeable about annunciator systems, nuclear plant control rooms, or both. This information should help licensees and license applicants in improving their hard-wired, control room annunciator systems as outlined by NUREG-0700.

  20. Statistical process control: An approach to quality assurance in the production of vitrified nuclear waste

    SciTech Connect

    Pulsipher, B.A.; Kuhn, W.L.

    1987-02-01

    Current planning for liquid high-level nuclear wastes existing in the US includes processing in a liquid-fed ceramic melter to incorporate it into a high-quality glass, and placement in a deep geologic repository. The nuclear waste vitrification process requires assurance of a quality product with little or no final inspection. Statistical process control (SPC) is a quantitative approach to one quality assurance aspect of vitrified nuclear waste. This method for monitoring and controlling a process in the presence of uncertainties provides a statistical basis for decisions concerning product quality improvement. Statistical process control is shown to be a feasible and beneficial tool to help the waste glass producers demonstrate that the vitrification process can be controlled sufficiently to produce an acceptable product. This quantitative aspect of quality assurance could be an effective means of establishing confidence in the claims to a quality product. 2 refs., 4 figs.

  1. Composite neutron absorbing coatings for nuclear criticality control

    DOEpatents

    Wright, Richard N.; Swank, W. David; Mizia, Ronald E.

    2005-07-19

    Thermal neutron absorbing composite coating materials and methods of applying such coating materials to spent nuclear fuel storage systems are provided. A composite neutron absorbing coating applied to a substrate surface includes a neutron absorbing layer overlying at least a portion of the substrate surface, and a corrosion resistant top coat layer overlying at least a portion of the neutron absorbing layer. An optional bond coat layer can be formed on the substrate surface prior to forming the neutron absorbing layer. The neutron absorbing layer can include a neutron absorbing material, such as gadolinium oxide or gadolinium phosphate, dispersed in a metal alloy matrix. The coating layers may be formed by a plasma spray process or a high velocity oxygen fuel process.

  2. Control of Nepheline Crystallization in Nuclear Waste Glass

    SciTech Connect

    Fox, Kevin

    2008-07-01

    Glass frits with a high B{sub 2}O{sub 3} concentration have been designed which, when combined with high-alumina concentration nuclear waste streams, will form glasses with durabilities that are acceptable for repository disposal and predictable using a free energy of hydration model. Two glasses with nepheline discriminator values closest to 0.62 showed significant differences in normalized boron release between the quenched and heat treated versions of each glass. X-ray diffraction confirmed that nepheline crystallized in the glass with the lowest nepheline discriminator value, and nepheline may also exist in the second glass as small nanocrystals. The high-B{sub 2}O{sub 3} frit was successful in producing simulated waste glasses with no detectable nepheline crystallization at waste loadings of up to 45 wt%. The melt rate of this frit was also considerably better than other frits with increased concentrations of Na{sub 2}O.

  3. Cationic surfactants for control of fresh- and saltwater mollusks in nuclear cooling systems

    SciTech Connect

    Post, R.M.; Mallen, E.; Lehmann, F.

    1991-11-01

    One result of the release of the US Nuclear Regulatory Commission's Generic Letter 89-13, Service Water Problems Affecting Safety-Related Equipment, was the heightened awareness of the nuclear industry to the problems of macrofouling in heat exchange systems. The principal mollusk species that contribute to freshwater macrofouling problems are Asiatic Clam (southern United States) and Zebra Mussel (Great Lakes). The predominant saltwater fouling mollusks are the Blue Mussel (Pacific, northern Atlantic), Ribbed Mussel (southern Atlantic, Gulf Coast), and American Oyster (Atlantic, Gulf Coast). The nuclear community's awareness of macrofouling problems and the ineffectiveness of intermittent chlorination programs have led to the development of several chemical control technologies for eliminating macrofouling organism infestation. One technology that has proven effective for the control of macrofouling organisms is the periodic addition of a combination of two cationic charged surfactants, specifically, alkyldimethylbenzylammonium chloride (QUAT) and dodecyl guanidine hydrochloride (DGH). Experience with the cationic surfactants at several nuclear power plants is reported.

  4. Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4*

    PubMed Central

    Spencer, Netanya Y.; Yan, Ziying; Boudreau, Ryan L.; Zhang, Yulong; Luo, Meihui; Li, Qiang; Tian, Xin; Shah, Ajay M.; Davisson, Robin L.; Davidson, Beverly; Banfi, Botond; Engelhardt, John F.

    2011-01-01

    Redox-regulated signal transduction is coordinated by spatially controlled production of reactive oxygen species within subcellular compartments. The nucleus has long been known to produce superoxide (O2⨪); however, the mechanisms that control this function remain largely unknown. We have characterized molecular features of a nuclear superoxide-producing system in the mouse liver. Using electron paramagnetic resonance, we investigated whether several NADPH oxidases (NOX1, 2, and 4) and known activators of NOX (Rac1, Rac2, p22phox, and p47phox) contribute to nuclear O2⨪ production in isolated hepatic nuclei. Our findings demonstrate that NOX4 most significantly contributes to hepatic nuclear O2⨪ production that utilizes NADPH as an electron donor. Although NOX4 protein immunolocalized to both nuclear membranes and intranuclear inclusions, fluorescent detection of NADPH-dependent nuclear O2⨪ predominantly localized to the perinuclear space. Interestingly, NADP+ and G6P also induced nuclear O2⨪ production, suggesting that intranuclear glucose-6-phosphate dehydrogenase (G6PD) can control NOX4 activity through nuclear NADPH production. Using G6PD mutant mice and G6PD shRNA, we confirmed that reductions in nuclear G6PD enzyme decrease the ability of hepatic nuclei to generate O2⨪ in response to NADP+ and G6P. NOX4 and G6PD protein were also observed in overlapping microdomains within the nucleus. These findings provide new insights on the metabolic pathways for substrate regulation of nuclear O2⨪ production by NOX4. PMID:21212270

  5. FRAMEWORK AND APPLICATION FOR MODELING CONTROL ROOM CREW PERFORMANCE AT NUCLEAR POWER PLANTS

    SciTech Connect

    Ronald L Boring; David I Gertman; Tuan Q Tran; Brian F Gore

    2008-09-01

    This paper summarizes an emerging project regarding the utilization of high-fidelity MIDAS simulations for visualizing and modeling control room crew performance at nuclear power plants. The key envisioned uses for MIDAS-based control room simulations are: (i) the estimation of human error associated with advanced control room equipment and configurations, (ii) the investigative determination of contributory cognitive factors for risk significant scenarios involving control room operating crews, and (iii) the certification of reduced staffing levels in advanced control rooms. It is proposed that MIDAS serves as a key component for the effective modeling of cognition, elements of situation awareness, and risk associated with human performance in next generation control rooms.

  6. Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator

    PubMed Central

    Scarpulla, Richard C.

    2010-01-01

    Expression of the respiratory apparatus depends on both nuclear and mitochondrial genes. Although these genes are sequestered in distinct cellular organelles, their transcription relies on nucleus-encoded factors. Certain of these factors are directed to the mitochondria, where they sponsor the bi-directional transcription of mitochondrial DNA. Others act on nuclear genes that encode the majority of the respiratory subunits and many other gene products required for the assembly and function of the respiratory chain. The nuclear respiratory factors, NRF-1 and NRF-2, contribute to the expression of respiratory subunits and mitochondrial transcription factors and thus have been implicated in nucleo-mitochondrial interactions. In addition, coactivators of the PGC-1 family serve as mediators between the environment and the transcriptional machinery governing mitochondrial biogenesis. One family member, peroxisome proliferator-activated receptor γ coactivator PGC-1-related coactivator (PRC), is an immediate early gene product that is rapidly induced by mitogenic signals in the absence of de novo protein synthesis. Like other PGC-1 family members, PRC binds NRF-1 and activates NRF-1 target genes. In addition, PRC complexes with NRF-2 and HCF-1 (host cell factor-1) in the activation of NRF-2-dependent promoters. HCF-1 functions in cell-cycle progression and has been identified as an NRF-2 coactivator. The association of these factors with PRC is suggestive of a role for the complex in cell growth. Finally, shRNA-mediated knock down of PRC expression results in a complex phenotype that includes the inhibition of respiratory growth on galactose and the loss of respiratory complexes. Thus, PRC may help integrate the expression of the respiratory apparatus with the cell proliferative program. PMID:19076454

  7. Nuclear Safety Functions of ITER Gas Injection System Instrumentation and Control and the Concept Design

    NASA Astrophysics Data System (ADS)

    Yang, Yu; Maruyama, S.; Fossen, A.; Villers, F.; Kiss, G.; Zhang, Bo; Li, Bo; Jiang, Tao; Huang, Xiangmei

    2016-08-01

    The ITER Gas Injection System (GIS) plays an important role on fueling, wall conditioning and distribution for plasma operation. Besides that, to support the safety function of ITER, GIS needs to implement three nuclear safety Instrumentation and Control (I&C) functions. In this paper, these three functions are introduced with the emphasis on their latest safety classifications. The nuclear I&C design concept is briefly discussed at the end.

  8. Export Control Guide: Loose Parts Monitoring Systems for Nuclear Power Plants

    SciTech Connect

    Langenberg, Donald W.

    2012-12-01

    This report describes a typical LPMS, emphasizing its application to the RCS of a modern NPP. The report also examines the versatility of AE monitoring technology by describing several nuclear applications other than loose parts monitoring, as well as some non-nuclear applications. In addition, LPMS implementation requirements are outlined, and LPMS suppliers are identified. Finally, U.S. export controls applicable to LPMSs are discussed.

  9. Application of American National Standards of calibration techniques of bulk measurements for nuclear materials control

    SciTech Connect

    Doher, L. W.; Gerald, K. B.

    1980-01-01

    In 1975 Subcommittee ANSI-INMM-8, Calibration Techniques for Nuclear Material Control under the guidance of the American National Standards Institute Committee N15 and sponsored by the Institute of Nuclear Materials Management, published four standards for calibration of bulk measurement of nuclear materials. The calibration techniques include those for mass, volume, nondestructive assay, and plutonium calorimetry measurements. Since that time, calibration and research personnel of the Rocky Flats Plant and workers at other facilities have applied the direction and guidance of these standards. Results of the applications are reported and th value of each standard discussed. Examples are included together with certain shortcomings and future revision plans.

  10. Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation

    PubMed Central

    Zimmerman, Seth P.; Bear, James E.; Goldstein, Bob; Hahn, Klaus; Kuhlman, Brian

    2015-01-01

    Light-activatable proteins allow precise spatial and temporal control of biological processes in living cells and animals. Several approaches have been developed for controlling protein localization with light, including the conditional inhibition of a nuclear localization signal (NLS) with the Light Oxygen Voltage (AsLOV2) domain of phototropin 1 from Avena sativa. In the dark, the switch adopts a closed conformation that sterically blocks the NLS motif. Upon activation with blue light the C-terminus of the protein unfolds, freeing the NLS to direct the protein to the nucleus. A previous study showed that this approach can be used to control the localization and activity of proteins in mammalian tissue culture cells. Here, we extend this result by characterizing the binding properties of a LOV/NLS switch and demonstrating that it can be used to control gene transcription in yeast. Additionally, we show that the switch, referred to as LANS (light-activated nuclear shuttle), functions in the C. elegans embryo and allows for control of nuclear localization in individual cells. By inserting LANS into the C. elegans lin-1 locus using Cas9-triggered homologous recombination, we demonstrated control of cell fate via light-dependent manipulation of a native transcription factor. We conclude that LANS can be a valuable experimental method for spatial and temporal control of nuclear localization in vivo. PMID:26083500

  11. Diversity Strategies for Nuclear Power Plant Instrumentation and Control Systems

    SciTech Connect

    Wood, Richard Thomas; Belles, Randy; Cetiner, Mustafa Sacit; Holcomb, David Eugene; Korsah, Kofi; Loebl, Andy; Mays, Gary T; Muhlheim, Michael David; Mullens, James Allen; Poore III, Willis P; Qualls, A L; Wilson, Thomas L; Waterman, Michael E.

    2010-02-01

    This report presents the technical basis for establishing acceptable mitigating strategies that resolve diversity and defense-in-depth (D3) assessment findings and conform to U.S. Nuclear Regulatory Commission (NRC) requirements. The research approach employed to establish appropriate diversity strategies involves investigation of available documentation on D3 methods and experience from nuclear power and nonnuclear industries, capture of expert knowledge and lessons learned, determination of best practices, and assessment of the nature of common-cause failures (CCFs) and compensating diversity attributes. The research described in this report does not provide guidance on how to determine the need for diversity in a safety system to mitigate the consequences of potential CCFs. Rather, the scope of this report provides guidance to the staff and nuclear industry after a licensee or applicant has performed a D3 assessment per NUREG/CR-6303 and determined that diversity in a safety system is needed for mitigating the consequences of potential CCFs identified in the evaluation of the safety system design features. Succinctly, the purpose of the research described in this report was to answer the question, 'If diversity is required in a safety system to mitigate the consequences of potential CCFs, how much diversity is enough?' The principal results of this research effort have identified and developed diversity strategies, which consist of combinations of diversity attributes and their associated criteria. Technology, which corresponds to design diversity, is chosen as the principal system characteristic by which diversity criteria are grouped to form strategies. The rationale for this classification framework involves consideration of the profound impact that technology-focused design diversity provides. Consequently, the diversity usage classification scheme involves three families of strategies: (1) different technologies, (2) different approaches within the same

  12. Temperature-controlled molecular depolarization gates in nuclear magnetic resonance

    SciTech Connect

    Schroder, Leif; Schroder, Leif; Chavez, Lana; Meldrum, Tyler; Smith, Monica; Lowery, Thomas J.; E. Wemmer, David; Pines, Alexander

    2008-02-27

    Down the drain: Cryptophane cages in combination with selective radiofrequency spin labeling can be used as molecular 'transpletor' units for transferring depletion of spin polarization from a hyperpolarized 'source' spin ensemble to a 'drain' ensemble. The flow of nuclei through the gate is adjustable by the ambient temperature, thereby enabling controlled consumption of hyperpolarization.

  13. Self-actuating and locking control for nuclear reactor

    DOEpatents

    Chung, Dong K.

    1982-01-01

    A self-actuating, self-locking flow cutoff valve particularly suited for use in a nuclear reactor of the type which utilizes a plurality of fluid support neutron absorber elements to provide for the safe shutdown of the reactor. The valve comprises a substantially vertical elongated housing and an aperture plate located in the housing for the flow of fluid therethrough, a substantially vertical elongated nozzle member located in the housing and affixed to the housing with an opening in the bottom for receiving fluid and apertures adjacent a top end for discharging fluid. The nozzle further includes two sealing means, one located above and the other below the apertures. Also located in the housing and having walls surrounding the nozzle is a flow cutoff sleeve having a fluid opening adjacent an upper end of the sleeve, the sleeve being moveable between an upper open position wherein the nozzle apertures are substantially unobstructed and a closed position wherein the sleeve and nozzle sealing surfaces are mated such that the flow of fluid through the apertures is obstructed. It is a particular feature of the present invention that the valve further includes a means for utilizing any increase in fluid pressure to maintain the cutoff sleeve in a closed position. It is another feature of the invention that there is provided a means for automatically closing the valve whenever the flow of fluid drops below a predetermined level.

  14. Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

    PubMed Central

    Glover, Lucy; Hutchinson, Sebastian; Alsford, Sam; McCulloch, Richard; Field, Mark C; Horn, David

    2013-01-01

    African trypanosomes are lethal human and animal parasites that use antigenic variation for evasion of host adaptive immunity. To facilitate antigenic variation, trypanosomes dedicate approximately one third of their nuclear genome, including many minichromosomes, and possibly all sub-telomeres, to variant surface glycoprotein (VSG) genes and associated sequences. Antigenic variation requires transcription of a single VSG by RNA polymerase I (Pol-I), with silencing of other VSGs, and periodic switching of the expressed gene, typically via DNA recombination with duplicative translocation of a new VSG to the active site. Thus, telomeric location, epigenetic controls and monoallelic transcription by Pol-I at an extranucleolar site are prominent features of VSGs and their expression, with telomeres, chromatin structure and nuclear organization all making vitally important contributions to monoallelic VSG expression control and switching. We discuss VSG transcription, recombination and replication control within this chromosomal and sub-nuclear context. PMID:24047558

  15. WTEC panel report on European nuclear instrumentation and controls. Final report

    SciTech Connect

    White, J.D.; Lanning, D.D.; Johnson, P.M.H.; Shelton, R.D.

    1991-12-01

    A study of instrumentation and controls (I and C) technology used in nuclear power plants in Europe was conducted by a panel of US specialists. This study plants in Europe was conducted by a panel of US specialists. This study included a review of the literature on the subject, followed by a visit to some of the leading organizations in Europe in the field nuclear I and C. Areas covered are: (1) role of the operator and control room design; (2) transition from analog to digital technology; (3) computerized operator support systems for fault management; (4) control strategies and techniques; (5) Nuclear power plant I and C architecture; (6) instrumentation and (7) computer standards and tools. The finding relate to poor reactions.

  16. Approaches to integrating nuclear weapons stockpile management and arms control objectives.

    SciTech Connect

    Sanders, Lani Miyoshi; DeLand, Sharon Marie; Pregenzer, Arian Leigh

    2010-06-01

    Historically, U.S. arms control policy and the U.S. nuclear weapons enterprise have been reactive to each other, rather than interdependent and mutually reinforcing. One element of the divergence has been the long timescale necessary to plan and create substantive changes in the infrastructure vs. the inherent unpredictability of arms control outcomes. We explore several examples that illustrate this tension, some of the costs and implications associated with this reactive paradigm, and illustrate that, while the nuclear weapons enterprise has long considered the implications of arms control in sizing capacity of its missions, it has not substantively considered arms control in construction requirement for capabilities and products. Since previous arms control agreements have limited numbers and types of deployed systems, with delivery systems as the object of verification, this disconnect has not been forefront. However, as future agreements unfold, the warhead itself may become the treaty limited item and the object of verification. Such a scenario might offer both the need and the opportunity to integrate nuclear weapons and arms control requirements in unprecedented ways. This paper seeks to inspire new thinking on how such integration could be fostered and the extent to which it can facilitate significant reduction in nuclear stockpiles.

  17. Instrumentation and Controls evaluation for space nuclear power systems

    SciTech Connect

    Anderson, J.L.; Oakes, L.C.

    1984-01-01

    Design of control and protection systems should be coordinated with the design of the neutronic, thermal-hydraulic, and mechanical aspects of the core and plant at the earliest possible stage of concept development. An integrated systematic design approach is necessary to prevent uncoordinated choices in one technology area from imposing impractical or impossible requirements in another. Significant development and qualification will be required for virtually every aspect of reactor control and instrumentation. In-core instrumentation widely used in commercial light water reactors will not likely be usable in the higher temperatures of a space power plant. Thermocouples for temperature measurement and gamma thermometers for flux measurement appear to be the only viable candidates. Recent developments in ex-core neutron detectors may provide achievable alternatives to in-core measurements. Reliable electronic equipment and high-temperature actuators will require major development efforts.

  18. Compatibility of refractory materials for nuclear reactor poison control systems

    NASA Technical Reports Server (NTRS)

    Sinclair, J. H.

    1974-01-01

    Metal-clad poison rods have been considered for the control system of an advanced space power reactor concept studied at the NASA Lewis Research Center. Such control rods may be required to operate at temperatures of about 140O C. Selected poison materials (including boron carbide and the diborides of zirconium, hafnium, and tantalum) were subjected to 1000-hour screening tests in contact with candidate refractory metal cladding materials (including tungsten and alloys of tantalum, niobium, and molybdenum) to assess the compatibility of these materials combinations at the temperatures of interest. Zirconium and hafnium diborides were compatible with refractory metals at 1400 C, but boron carbide and tantalum diboride reacted with the refractory metals at this temperature. Zirconium diboride also showed promise as a reaction barrier between boron carbide and tungsten.

  19. High-fidelity readout and control of a nuclear spin qubit in silicon.

    PubMed

    Pla, Jarryd J; Tan, Kuan Y; Dehollain, Juan P; Lim, Wee H; Morton, John J L; Zwanenburg, Floris A; Jamieson, David N; Dzurak, Andrew S; Morello, Andrea

    2013-04-18

    Detection of nuclear spin precession is critical for a wide range of scientific techniques that have applications in diverse fields including analytical chemistry, materials science, medicine and biology. Fundamentally, it is possible because of the extreme isolation of nuclear spins from their environment. This isolation also makes single nuclear spins desirable for quantum-information processing, as shown by pioneering studies on nitrogen-vacancy centres in diamond. The nuclear spin of a (31)P donor in silicon is very promising as a quantum bit: bulk measurements indicate that it has excellent coherence times and silicon is the dominant material in the microelectronics industry. Here we demonstrate electrical detection and coherent manipulation of a single (31)P nuclear spin qubit with sufficiently high fidelities for fault-tolerant quantum computing. By integrating single-shot readout of the electron spin with on-chip electron spin resonance, we demonstrate quantum non-demolition and electrical single-shot readout of the nuclear spin with a readout fidelity higher than 99.8 percent-the highest so far reported for any solid-state qubit. The single nuclear spin is then operated as a qubit by applying coherent radio-frequency pulses. For an ionized (31)P donor, we find a nuclear spin coherence time of 60 milliseconds and a one-qubit gate control fidelity exceeding 98 percent. These results demonstrate that the dominant technology of modern electronics can be adapted to host a complete electrical measurement and control platform for nuclear-spin-based quantum-information processing. PMID:23598342

  20. Impact of holmium fibre laser radiation (λ = 2.1 μm) on the spinal cord dura mater and adipose tissue

    NASA Astrophysics Data System (ADS)

    Filatova, S. A.; Kamynin, V. A.; Ryabova, A. V.; Loshchenov, V. B.; Zelenkov, P. V.; Zolotovskii, I. O.; Tsvetkov, V. B.; Kurkov, A. S.

    2015-08-01

    The impact of holmium fibre laser radiation on the samples of biologic tissues (dura mater of spinal cord and adipose tissue with interlayers of muscle) is studied. The experimental results are evaluated by the size of carbonisation and coagulation necrosis zones. The experiment shows that in the case of irradiation of the spinal cord dura mater samples the size of carbonisation and coagulation necrosis zones is insignificant. In the adipose tissue the carbonisation zone is also insignificant, but the region of cellular structure disturbance is large. In the muscle tissue the situation is opposite. The cw laser operation provides clinically acceptable degree of destruction in tissue samples with a minimal carbonisation zone.

  1. Proceedings of the second US Department of Energy environmental control symposium. Volume 2. Nuclear energy, conservation, and solar energy

    SciTech Connect

    1980-06-01

    These proceedings document the presentations given at the Second Environmental Control Symposium. Symposium presentations highlighted environmental control activities which span the entire DOE. Volume II contains papers relating to: environmental control aspects of nuclear energy use and development; nuclear waste management; renewable energy sources; transportation and building conservation (fuel economy, gasohol, building standards, and industry); and geothermal energy, power transmission, and energy storage. (DMC)

  2. Dual annular rotating [open quotes]windowed[close quotes] nuclear reflector reactor control system

    DOEpatents

    Jacox, M.G.; Drexler, R.L.; Hunt, R.N.M.; Lake, J.A.

    1994-03-29

    A nuclear reactor control system is provided in a nuclear reactor having a core operating in the fast neutron energy spectrum where criticality control is achieved by neutron leakage. The control system includes dual annular, rotatable reflector rings. There are two reflector rings: an inner reflector ring and an outer reflector ring. The reflectors are concentrically assembled, surround the reactor core, and each reflector ring includes a plurality of openings. The openings in each ring are capable of being aligned or non-aligned with each other. Independent driving means for each of the annular reflector rings is provided so that reactor criticality can be initiated and controlled by rotation of either reflector ring such that the extent of alignment of the openings in each ring controls the reflection of neutrons from the core. 4 figures.

  3. Hydraulic balancing of a control component within a nuclear reactor

    DOEpatents

    Marinos, D.; Ripfel, H.C.F.

    1975-10-14

    A reactor control component includes an inner conduit, for instance containing neutron absorber elements, adapted for longitudinal movement within an outer guide duct. A transverse partition partially encloses one end of the conduit and meets a transverse wall within the guide duct when the conduit is fully inserted into the reactor core. A tube piece extends from the transverse partition and is coaxially aligned to be received within a tubular receptacle which extends from the transverse wall. The tube piece and receptacle cooperate in engagement to restrict the flow and pressure of coolant beneath the transverse partition and thereby minimize upward forces tending to expel the inner conduit.

  4. Technology Roadmap Instrumentation, Control, and Human-Machine Interface to Support DOE Advanced Nuclear Energy Programs

    SciTech Connect

    Donald D Dudenhoeffer; Burce P Hallbert

    2007-03-01

    Instrumentation, Controls, and Human-Machine Interface (ICHMI) technologies are essential to ensuring delivery and effective operation of optimized advanced Generation IV (Gen IV) nuclear energy systems. In 1996, the Watts Bar I nuclear power plant in Tennessee was the last U.S. nuclear power plant to go on line. It was, in fact, built based on pre-1990 technology. Since this last U.S. nuclear power plant was designed, there have been major advances in the field of ICHMI systems. Computer technology employed in other industries has advanced dramatically, and computing systems are now replaced every few years as they become functionally obsolete. Functional obsolescence occurs when newer, more functional technology replaces or supersedes an existing technology, even though an existing technology may well be in working order.Although ICHMI architectures are comprised of much of the same technology, they have not been updated nearly as often in the nuclear power industry. For example, some newer Personal Digital Assistants (PDAs) or handheld computers may, in fact, have more functionality than the 1996 computer control system at the Watts Bar I plant. This illustrates the need to transition and upgrade current nuclear power plant ICHMI technologies.

  5. Sliding Mode Approaches for Robust Control, State Estimation, Secure Communication, and Fault Diagnosis in Nuclear Systems

    NASA Astrophysics Data System (ADS)

    Ablay, Gunyaz

    Using traditional control methods for controller design, parameter estimation and fault diagnosis may lead to poor results with nuclear systems in practice because of approximations and uncertainties in the system models used, possibly resulting in unexpected plant unavailability. This experience has led to an interest in development of robust control, estimation and fault diagnosis methods. One particularly robust approach is the sliding mode control methodology. Sliding mode approaches have been of great interest and importance in industry and engineering in the recent decades due to their potential for producing economic, safe and reliable designs. In order to utilize these advantages, sliding mode approaches are implemented for robust control, state estimation, secure communication and fault diagnosis in nuclear plant systems. In addition, a sliding mode output observer is developed for fault diagnosis in dynamical systems. To validate the effectiveness of the methodologies, several nuclear plant system models are considered for applications, including point reactor kinetics, xenon concentration dynamics, an uncertain pressurizer model, a U-tube steam generator model and a coupled nonlinear nuclear reactor model.

  6. Coherent control of a single ²⁹Si nuclear spin qubit.

    PubMed

    Pla, Jarryd J; Mohiyaddin, Fahd A; Tan, Kuan Y; Dehollain, Juan P; Rahman, Rajib; Klimeck, Gerhard; Jamieson, David N; Dzurak, Andrew S; Morello, Andrea

    2014-12-12

    Magnetic fluctuations caused by the nuclear spins of a host crystal are often the leading source of decoherence for many types of solid-state spin qubit. In group-IV semiconductor materials, the spin-bearing nuclei are sufficiently rare that it is possible to identify and control individual host nuclear spins. This Letter presents the first experimental detection and manipulation of a single ²⁹Si nuclear spin. The quantum nondemolition single-shot readout of the spin is demonstrated, and a Hahn echo measurement reveals a coherence time of T₂=6.3(7)  ms—in excellent agreement with bulk experiments. Atomistic modeling combined with extracted experimental parameters provides possible lattice sites for the ²⁹Si atom under investigation. These results demonstrate that single ²⁹Si nuclear spins could serve as a valuable resource in a silicon spin-based quantum computer. PMID:25541792

  7. Processing used nuclear fuel with nanoscale control of uranium and ultrafiltration

    NASA Astrophysics Data System (ADS)

    Wylie, Ernest M.; Peruski, Kathryn M.; Prizio, Sarah E.; Bridges, Andrea N. A.; Rudisill, Tracy S.; Hobbs, David T.; Phillip, William A.; Burns, Peter C.

    2016-05-01

    Current separation and purification technologies utilized in the nuclear fuel cycle rely primarily on liquid-liquid extraction and ion-exchange processes. Here, we report a laboratory-scale aqueous process that demonstrates nanoscale control for the recovery of uranium from simulated used nuclear fuel (SIMFUEL). The selective, hydrogen peroxide induced oxidative dissolution of SIMFUEL material results in the rapid assembly of persistent uranyl peroxide nanocluster species that can be separated and recovered at moderate to high yield from other process-soluble constituents using sequestration-assisted ultrafiltration. Implementation of size-selective physical processes like filtration could results in an overall simplification of nuclear fuel cycle technology, improving the environmental consequences of nuclear energy and reducing costs of processing.

  8. Microscopic control of 29Si nuclear spins near phosphorus donors in silicon

    NASA Astrophysics Data System (ADS)

    Järvinen, J.; Zvezdov, D.; Ahokas, J.; Sheludyakov, S.; Vainio, O.; Lehtonen, L.; Vasiliev, S.; Fujii, Y.; Mitsudo, S.; Mizusaki, T.; Gwak, M.; Lee, SangGap; Lee, Soonchil; Vlasenko, L.

    2015-09-01

    We demonstrate an efficient control of 29Si nuclear spins for specific lattice sites near 31P donors in silicon at temperatures below 1 K and in a high magnetic field of 4.6 T. Excitation of the forbidden electron-nuclear transitions leads to a pattern of well-resolved holes and peaks in the electron spin resonance (ESR) lines of 31P . The pattern originates from dynamic polarization (DNP) of the 29Si nuclear spins near the donors via the solid effect. DNP of 29Si is demonstrated also with the Overhauser effect where the allowed ESR transitions are excited. In this case mostly the remote 29Si nuclei having weak interaction with the donors are polarized, which results in a single hole and a sharp peak pair in the ESR spectrum. Our work shows that the solid effect can be used for initialization of 29Si nuclear spin qubits near the donors.

  9. Nuclear export controls and the CTBT: Where we`ve been and challenges ahead -- Views of an engineer

    SciTech Connect

    Lundy, A.S.

    1998-09-01

    The paper discusses the following topics: the importance of export controls; the uniqueness of nuclear weapons and their export control requirements; ``dual-use`` controls; and recent developments in nonproliferation beyond export control. Also discussed are some non-obvious challenges which include computer modeling and visualization, and fissile material availability and instant nukes. The author concludes by asking the Nuclear Suppliers Group to consider whether there are ways to make its controls more effective.

  10. Developing Global Perspectives about Nuclear Arms Control among Proactive Action Students in Rural Schools: A Teacher's Guide.

    ERIC Educational Resources Information Center

    Peters, Richard

    A teacher's guide to developing global perspectives about nuclear arms control among proactive action students in rural schools oulines the historical development of the current nuclear situation, describes a nuclear age curriculum, explains the importance of proactive and global perspectives, covers simulated situations, and provides a glossary…

  11. Application of telerobotic control to remote processing of nuclear material

    SciTech Connect

    Merrill, R.D.; Grasz, E.L.; Herget, C.J.; Gavel, D.T.; Addis, R.B.; DeMinico, G.A.

    1991-07-08

    In processing radioactive material there are certain steps which have customarily required operators working at glove box enclosures. This can subject the operators to low level radiation dosages and the risk of accidental contamination, as well as generate significant radioactive waste to accommodate the human interaction. An automated system is being developed to replace the operator at the glove box and thus remove the human from these risks, and minimize waste. Although most of the processing can be automated with very little human operator interaction, there are some tasks where intelligent intervention is necessary to adapt to unexpected circumstances and events. These activities will require that the operator be able to interact with the process using a remote manipulator in a manner as natural as if the operator were actually in the work cell. This robot-based remote manipulation system, or telerobot, must provide the operator with an effective means of controlling the robot arm, gripper and tools. This paper describes the effort in progress in Lawrence Livermore National Laboratory to achieve this capability. 8 refs.

  12. Sliding mode control of the space nuclear reactor system TOPAZ II

    SciTech Connect

    Shtessel, Y.B.; Wyant, F.J.

    1996-03-01

    The Automatic Control System (ACS) of the space nuclear reactor power system TOPAZ II that generates electricity from nuclear heat using in-core thermionic converters is considered. Sliding Mode Control Technique was applied to the reactor system controller design in order to provide the robust high accuracy following of a neutron (thermal) power reference profile in a start up regime and a payload electric power (current) reference profile following in an operation regime. Extensive simulations of the TOPAZ II reactor system with the designed sliding mode controllers showed improved accuracy and robustness of the reactor system performances in a start up regime and in an electric power supply regime as well. {copyright} {ital 1996 American Institute of Physics.}

  13. Export control guide: Spent nuclear fuel reprocessing and preparation of plutonium metal

    SciTech Connect

    1993-10-01

    The international Treaty on the Non-Proliferation of Nuclear Weapons, also referred to as the Non-Proliferation Treaty (NPT), states in Article III, paragraph 2(b) that {open_quotes}Each State Party to the Treaty undertakes not to provide . . . equipment or material especially designed or prepared for the processing, use or production of special fissionable material to any non-nuclear-weapon State for peaceful purposes, unless the source or special fissionable material shall be subject to the safeguards required by this Article.{close_quotes} This guide was prepared to assist export control officials in the interpretation, understanding, and implementation of export laws and controls relating to the international Trigger List for irradiated nuclear fuel reprocessing equipment, components, and materials. The guide also contains information related to the production of plutonium metal. Reprocessing and its place in the nuclear fuel cycle are described briefly; the standard procedure to prepare metallic plutonium is discussed; steps used to prepare Trigger List controls are cited; descriptions of controlled items are given; and special materials of construction are noted. This is followed by a comprehensive description of especially designed or prepared equipment, materials, and components of reprocessing and plutonium metal processes and includes photographs and/or pictorial representations. The nomenclature of the Trigger List has been retained in the numbered sections of this document for clarity.

  14. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Information exempt from being Unclassified Controlled Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS... protected from disclosure under section 147 of the Atomic Energy Act (42 U.S.C. 2167) that is identified...

  15. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Unclassified Controlled Nuclear Information markings on documents or material. 1017.16 Section 1017.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS... criminal sanctions under section 148 of the Atomic Energy Act of 1954, as amended (42 U.S.C....

  16. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Unclassified Controlled Nuclear Information markings on documents or material. 1017.16 Section 1017.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS... criminal sanctions under section 148 of the Atomic Energy Act of 1954, as amended (42 U.S.C....

  17. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Information exempt from being Unclassified Controlled Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS... protected from disclosure under section 147 of the Atomic Energy Act (42 U.S.C. 2167) that is identified...

  18. 10 CFR 1017.16 - Unclassified Controlled Nuclear Information markings on documents or material.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Unclassified Controlled Nuclear Information markings on documents or material. 1017.16 Section 1017.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS... criminal sanctions under section 148 of the Atomic Energy Act of 1954, as amended (42 U.S.C....

  19. 10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Information exempt from being Unclassified Controlled Nuclear Information. 1017.11 Section 1017.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS... protected from disclosure under section 147 of the Atomic Energy Act (42 U.S.C. 2167) that is identified...

  20. Development and Testing of a Nuclear Quality Assurance/Quality Control Technician Curriculum. Final Report.

    ERIC Educational Resources Information Center

    Espy, John; And Others

    A project was conducted to field test selected first- and second-year courses in a postsecondary nuclear quality assurance/quality control (QA/QC) technician curriculum and to develop the teaching/learning modules for seven technical specialty courses remaining in the QA/QC technician curriculum. The field testing phase of the project involved the…

  1. A pilot workshop of nuclear material accounting and control of facilities

    SciTech Connect

    Li, T. K.; Wilkey, D. D.

    2004-01-01

    With collaboration among the US Department of Energy, International Atomic Energy Agency (IAEA), and the China Atomic Energy Authority (CAEA), we have developed a Pilot Workshop of Nuclear Material Accounting and Control at Facilities and offered on May 19-June 1, 2004 in Beijing, China. The purpose of the workshop is to provide instruction in facility-level safeguards and security to participants from China and other invited countries a variation on the traditional State System of Accounting and Control (SSAC) by focusing on the nuclear material control and accounting (MC&A) measures as applied at the facility level. Moreover, the shift in emphasis from the state system of accounting and control to the facility level offers an opportunity to address insider and terrorist threats. In this manner, the traditional SSAC course would be merged with issues more closely associated with nuclear security and terrorism prevention. All instruction and practical exercises were in English with sequential interpretation into Chinese. The workshop materials were in both English and Chinese. In addition to course lectures and invited guest lectures, all participants visited to a nuclear fuel fabrication plant used as a model for an exercise in designing the safeguards system for a bulk facility. This paper reports the result and experience of the workshop and discusses the course evaluation from participants.

  2. 5 CFR 842.405 - Air traffic controllers, firefighters, law enforcement officers, and nuclear materials couriers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Air traffic controllers, firefighters, law enforcement officers, and nuclear materials couriers. 842.405 Section 842.405 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-BASIC ANNUITY Computations...

  3. Control rod system useable for fuel handling in a gas-cooled nuclear reactor

    DOEpatents

    Spurrier, Francis R.

    1976-11-30

    A control rod and its associated drive are used to elevate a complete stack of fuel blocks to a position above the core of a gas-cooled nuclear reactor. A fuel-handling machine grasps the control rod and the drive is unlatched from the rod. The stack and rod are transferred out of the reactor, or to a new location in the reactor, by the fuel-handling machine.

  4. Method of installing a control room console in a nuclear power plant

    DOEpatents

    Scarola, Kenneth; Jamison, David S.; Manazir, Richard M.; Rescorl, Robert L.; Harmon, Daryl L.

    1994-01-01

    An advanced control room complex for a nuclear power plant, including a discrete indicator and alarm system (72) which is nuclear qualified for rapid response to changes in plant parameters and a component control system (64) which together provide a discrete monitoring and control capability at a panel (14-22, 26, 28) in the control room (10). A separate data processing system (70), which need not be nuclear qualified, provides integrated and overview information to the control room and to each panel, through CRTs (84) and a large, overhead integrated process status overview board (24). The discrete indicator and alarm system (72) and the data processing system (70) receive inputs from common plant sensors and validate the sensor outputs to arrive at a representative value of the parameter for use by the operator during both normal and accident conditions, thereby avoiding the need for him to assimilate data from each sensor individually. The integrated process status board (24) is at the apex of an information hierarchy that extends through four levels and provides access at each panel to the full display hierarchy. The control room panels are preferably of a modular construction, permitting the definition of inputs and outputs, the man machine interface, and the plant specific algorithms, to proceed in parallel with the fabrication of the panels, the installation of the equipment and the generic testing thereof.

  5. Advanced international training course on state systems of accounting for and control of nuclear materials

    SciTech Connect

    Not Available

    1981-10-01

    This report incorporates all lectures and presentations at the Advanced International Training Course on State Systems of Accounting for and Control of Nuclear Material held April 27 through May 12, 1981 at Santa Fe and Los Alamos, New Mexico, and Richland, Washington, USA. Authorized by the US Nuclear Non-Proliferation Act and sponsored by the US Department of Energy in cooperation with the International Atomic Energy Agency, the course was developed to provide practical training in the design, implementation, and operation of a state system of nuclear materials accountability and control that satisfies both national and international safeguards. Major emphasis for the 1981 course was placed on safeguards methods used at bulk-handling facilities, particularly low-enriched uranium conversion and fuel fabrication plants. The course was conducted by the University of California's Los Alamos National Laboratory, the Battelle Pacific Northwest Laboratory, and Exxon Nuclear Company, Inc. Tours and demonstrations were arranged at both the Los Alamos National Laboratory, Los Alamos, New Mexico, and the Exxon Nuclear fuel fabrication plant, Richland, Washington.

  6. Introduction to digital instrumentation and control techniques used in nuclear engineering

    SciTech Connect

    Kurilla, R.G.; Kenney, E.S.

    1988-01-01

    For the past 8 yr, the nuclear engineering department at Pennsylvania State University has been teaching a digital interfacing class at the undergraduate (senior) level. With the ever-increasing use of computers in the nuclear engineering area (such as in the use of automated data acquisition systems) and the complexity of control instrumentation, more than a cursory introduction into electronics and computer controls is needed. Because of the ever-increasing popularity, and hence importance, of IBM-PC compatible microcomputers in the engineering fields, the program has been adapted to the Intel 8086 microprocessor. Courses such as this one are helpful in ensuring the students have an adequate design and practice base as required by accrediting groups. The course, is composed of three parts: (1) machine code/assembly language, (2) interfacing, and (3) final project. Experience demonstrates that a course of this inherent complexity can successfully be taught within a nuclear engineering curriculum without extensive prerequisites. The important ingredient is to treat nuclear engineering students for exactly what they are, engineers. By having them use their creativity and adaptability, they can successfully integrate the digital interfacing techniques now routinely used in the nuclear industry.

  7. Overlapping signal sequences control nuclear localization and endoplasmic reticulum retention of GRP58

    SciTech Connect

    Adikesavan, Anbu Karani; Unni, Emmanual; Jaiswal, Anil K.

    2008-12-12

    Glucose-regulated GRP58 has shown clinical applications to endoplasmic reticulum (ER) stress and cancer. GRP58 is localized in the cytosol, endoplasmic reticulum (ER) and nucleus. Twenty-four amino acids at the N-terminal hydrophobic region are known to target GRP58 to ER for synthesis at the ER membrane and translocation into the ER lumen. In addition, GRP58 contains putative nuclear localization (494KPKKKKK500) and ER retention (502QEDL505) signals. However, the role of these signals in nuclear import and ER retention of GRP58 remains unknown. Present studies investigated the signals that control nuclear localization and ER retention of GRP58. Deletion/mutation of nuclear localization signal (NLS) abrogated nuclear import of GRP58. NLS attached to EGFP localized EGFP in the nucleus. However, deletion/mutation of putative ER retention signal alone did not alter ER retention of GRP58. Interestingly, a combined deletion/mutation of NLS and ER retention signals blocked the GRP58 retention in the ER. These results concluded that overlapping NLS and ER retention signal sequences regulate nuclear localization and ER retention of GRP58.

  8. All-electrical control of a singlet-triplet qubit coupled to a single nuclear spin

    NASA Astrophysics Data System (ADS)

    Jacobson, N. Tobias; Harvey-Collard, Patrick; Baczewski, Andrew; Gamble, John; Rudolph, Martin; Nielsen, Erik; Muller, Richard; Carroll, Malcolm

    Donor nuclear spins in isotopically purified silicon have very long coherence times, suggesting that they may form high-quality quantum memories. We propose that coupling these nuclear spins to few-electron quantum dots could enable nuclear spin readout and two-qubit operations of the joint quantum dot and nuclear spin system without the need for electron spin resonance. As a step towards this goal, our group recently demonstrated coherent singlet/triplet electron spin rotations induced by the hyperfine interaction between electronic spin degrees of freedom and a single nuclear spin in isotopically purified silicon. In this talk, I will discuss the feasibility of universal all-electrical control of such a singlet/triplet electron spin qubit and explore the decoherence mechanisms that we expect to dominate. Finally, I will examine the relative merits of AC and pulsed DC gating schemes. Sandia is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the US Department of Energy National Nuclear Security Administration under Contract No. DE-AC04- 94AL85000.

  9. Leo Szilard Lectureship Award Talk: Controlling and eliminating nuclear-weapon materials

    NASA Astrophysics Data System (ADS)

    von Hippel, Frank

    2010-02-01

    Fissile material -- in practice plutonium and highly enriched uranium (HEU) -- is the essential ingredient in nuclear weapons. Controlling and eliminating fissile material and the means of its production is therefore the common denominator for nuclear disarmament, nuclear non-proliferation and the prevention of nuclear terrorism. From a fundamentalist anti-nuclear-weapon perspective, the less fissile material there is and the fewer locations where it can be found, the safer a world we will have. A comprehensive fissile-material policy therefore would have the following elements: *Consolidation of all nuclear-weapon-usable materials at a minimum number of high-security sites; *A verified ban on the production of HEU and plutonium for weapons; *Minimization of non-weapon uses of HEU and plutonium; and *Elimination of all excess stocks of plutonium and HEU. There is activity on all these fronts but it is not comprehensive and not all aspects are being pursued vigorously or competently. It is therefore worthwhile to review the situation. )

  10. Atypical symptoms in patients with cervical spondylosis might be the result of stimulation on the dura mater and spinal cord.

    PubMed

    Muheremu, Aikeremujiang; Sun, Yuqing

    2016-06-01

    Patients with cervical spondylosis often present with some atypical symptoms such as vertigo, headache, palpitation, nausea, abdominal discomfort, tinnitus and blurred vision and hypomnesia. Although there are a few hypotheses about the etiology of those symptoms, none of them have provided evidence convincing enough to explain the clinical, pathological and anatomic manifestation of those symptoms. One of the more acceptable explanations is that those symptoms are the results of stimulation of the sympathetic nerves in the posterior longitudinal ligament. The clinical fact that dissection of the posterior longitudinal ligament significantly alleviates the severity of those symptoms seems like an evidence for the validity of this hypothesis. However, recent clinical studies showed that laminoplasty, which has no effect on the posterior longitudinal ligament, can achieve the similar effect. In this paper, we hypothesize that stimulation of the dura mater and spinal cord might be the cause of atypical symptoms in patients with cervical spondylosis. PMID:27142142

  11. H{sub {infinity}} Control Theory Applied to Xenon Control for Load-Following Operation of a Nuclear Reactor

    SciTech Connect

    Chi, Sung Goo; Cho, Nam Zin

    2002-02-15

    A robust controller is designed by applying the H{sub {infinity}} optimal control theory to the xenon control for the load-following operation of a nuclear reactor. The set of reactor model equations for controller design is a stiff system. This singularly perturbed system arises from the interaction of slow dynamics modes (iodine and xenon concentrations) and fast dynamics modes (neutron density, fuel and coolant temperatures). The singular perturbation technique is used to overcome this stiffness problem. The design specifications are incorporated by the frequency weights using the mixed-sensitivity problem approach. The robustness of H{sub {infinity}} control is demonstrated by comparing it with linear quadratic Gaussian (LQG) control in the case of a measurement delay of the power measurement system.Since the gains and phase margins of H{sub {infinity}} control are larger than those of LQG control, the H{sub {infinity}} control is expected to provide excellent stability robustness and performance robustness against external disturbances and noises, model parameter variations, and modeling errors as well as hardware failures. It may also provide a practical design method because the design specifications can be easily implemented by the frequency weights.

  12. A brief review of intermediate controlled nuclear syntheses (ICNS) without harmful radiations

    SciTech Connect

    Lanjewar, R. B.

    2015-03-10

    Hadronic mechanics gave birth to new magnecular fuels. The present day demand is of clean energy source that is cheap and abundant. Clean energy can be obtained by harnessing renewable energy sources like solar, wind etc. Nuclear energy conventionally produced by fission reactions emits hazardous radiation and radioactive waste. The requirements of clean and safe energy gets fulfilled by novel fuel that achieved by elevating the traditional quantum mechanics to hadronic mechanics and to hadronic chemistry. In the present paper, a comprehensive review on both the theoretical and experimental aspect of the Intermediate Controlled Nuclear Synthesis (ICNS) as developed by Italian American Scientist Professor R. M. Santilli.

  13. Controlling the Excited-State Dynamics of Nuclear Spin Isomers Using the Dynamic Stark Effect.

    PubMed

    Waldl, Maria; Oppel, Markus; González, Leticia

    2016-07-14

    Stark control of chemical reactions uses intense laser pulses to distort the potential energy surfaces of a molecule, thus opening new chemical pathways. We use the concept of Stark shifts to convert a local minimum into a local maximum of the potential energy surface, triggering constructive and destructive wave-packet interferences, which then induce different dynamics on nuclear spin isomers in the electronically excited state of a quinodimethane derivative. Model quantum-dynamical simulations on reduced dimensionality using optimized ultrashort laser pulses demonstrate a difference of the excited-state dynamics of two sets of nuclear spin isomers, which ultimately can be used to discriminate between these isomers. PMID:26840424

  14. Nuclear Technology Requires Control by the People, anywhere on Our Planet.

    NASA Astrophysics Data System (ADS)

    Synek, Miroslav

    2000-03-01

    ------- Human society on our planet, in its historical development, utilizing the knowledge of physics, has reached a powerful technology of nuclear intercontinental ballistic missiles, conceivably controllable through a computerized "push-button". Whenever this technology falls under the control of an irresponsible , miscalculating, or, insane, DICTATOR, with powerful means of a mass-produced nuclear built-up, anywhere on our planet, the very survival of all humanity on our planet could be threatened. --- Therefore, it is a historical urgency that this technology is under the control by a government of the people, by the people and for the people, based on a sufficiently secure system of FREE ELECTIONS, in any country on our planet, wherever and whenever such a threatening possibility exists.

  15. Coupling and control in coherently driven and asymmetrically synchronized hybrid electron-nuclear spin system

    NASA Astrophysics Data System (ADS)

    Berec, V.

    2016-02-01

    We study the coupling and control adaptation of a hybrid electron-nuclear spin system using the laser mediated proton beam in MeV energy regime. The asymmetric control mechanism is based on exact optimization of both: the measure of exchange interaction and anisotropy of the hyperfine interaction induced in the resonance with optimal channeled protons (CP) superfocused field, allowing manipulation over arbitrary localized spatial centers while addressing only the electron spin. Using highly precise and coherent proton channeling regime we have obtained efficient pulse shaping separator technique aimed for spatio-temporal engineering of quantum states, introducing a method for control of nuclear spins, which are coupled via anisotropic hyperfine interactions in isolated electron spin manifold, without radio wave (RW) pulses. The presented method can be efficiently implemented in synchronized spin networks with the purpose to facilitate preservation and efficient transfer of experimentally observed quantum particle states, contributing to the overall background noise reduction.

  16. Applying Human Factors Evaluation and Design Guidance to a Nuclear Power Plant Digital Control System

    SciTech Connect

    Thomas Ulrich; Ronald Boring; William Phoenix; Emily Dehority; Tim Whiting; Jonathan Morrell; Rhett Backstrom

    2012-08-01

    The United States (U.S.) nuclear industry, like similar process control industries, has moved toward upgrading its control rooms. The upgraded control rooms typically feature digital control system (DCS) displays embedded in the panels. These displays gather information from the system and represent that information on a single display surface. In this manner, the DCS combines many previously separate analog indicators and controls into a single digital display, whereby the operators can toggle between multiple windows to monitor and control different aspects of the plant. The design of the DCS depends on the function of the system it monitors, but revolves around presenting the information most germane to an operator at any point in time. DCSs require a carefully designed human system interface. This report centers on redesigning existing DCS displays for an example chemical volume control system (CVCS) at a U.S. nuclear power plant. The crucial nature of the CVCS, which controls coolant levels and boration in the primary system, requires a thorough human factors evaluation of its supporting DCS. The initial digital controls being developed for the DCSs tend to directly mimic the former analog controls. There are, however, unique operator interactions with a digital vs. analog interface, and the differences have not always been carefully factored in the translation of an analog interface to a replacement DCS. To ensure safety, efficiency, and usability of the emerging DCSs, a human factors usability evaluation was conducted on a CVCS DCS currently being used and refined at an existing U.S. nuclear power plant. Subject matter experts from process control engineering, software development, and human factors evaluated the DCS displays to document potential usability issues and propose design recommendations. The evaluation yielded 167 potential usability issues with the DCS. These issues should not be considered operator performance problems but rather opportunities

  17. Measuring Human Performance in Simulated Nuclear Power Plant Control Rooms Using Eye Tracking

    SciTech Connect

    Kovesdi, Casey Robert; Rice, Brandon Charles; Bower, Gordon Ross; Spielman, Zachary Alexander; Hill, Rachael Ann; LeBlanc, Katya Lee

    2015-11-01

    Control room modernization will be an important part of life extension for the existing light water reactor fleet. As part of modernization efforts, personnel will need to gain a full understanding of how control room technologies affect performance of human operators. Recent advances in technology enables the use of eye tracking technology to continuously measure an operator’s eye movement, which correlates with a variety of human performance constructs such as situation awareness and workload. This report describes eye tracking metrics in the context of how they will be used in nuclear power plant control room simulator studies.

  18. Reflected kinetics model for nuclear space reactor kinetics and control scoping calculations

    SciTech Connect

    Washington, K.E.

    1986-05-01

    The objective of this research is to develop a model that offers an alternative to the point kinetics (PK) modelling approach in the analysis of space reactor kinetics and control studies. Modelling effort will focus on the explicit treatment of control drums as reactivity input devices so that the transition to automatic control can be smoothly done. The proposed model is developed for the specific integration of automatic control and the solution of the servo mechanism problem. The integration of the kinetics model with an automatic controller will provide a useful tool for performing space reactor scoping studies for different designs and configurations. Such a tool should prove to be invaluable in the design phase of a space nuclear system from the point of view of kinetics and control limitations.

  19. Fuzzy Logic Controller Architecture for Water Level Control in Nuclear Power Plant Steam Generator (SG) Using ANFIS Training Method

    SciTech Connect

    Vosoughi, Naser; Naseri, Zahra

    2002-07-01

    Since suitable control of water level can greatly enhance the operation of a power station, a Fuzzy logic controller architecture is applied to show desired control of the water level in a Nuclear steam generator. with regard to the physics of the system, it is shown that two inputs, a single output and the least number of rules (9 rules) are considered for a controller, and the ANFIS training method is employed to model functions in a controlled system. By using ANFIS training method, initial member functions will be trained and appropriate functions are generated to control water level inside the steam generators while using the stated rules. The proposed architecture can construct an input output mapping based on both human knowledge (in from of Fuzzy if then rules) and stipulated input output data. In this paper with a simple test it has been shown that the architecture fuzzy logic controller has a reasonable response to one step input at a constant power. Through computer simulation, it is found that Fuzzy logic controller is suitable, especially for the water level deviation and abrupt steam flow disturbances that are typical in the existing power plant. (authors)

  20. Posttranslational marks control architectural and functional plasticity of the nuclear pore complex basket

    PubMed Central

    Niño, Carlos A.; Guet, David; Gay, Alexandre; Brutus, Sergine; Jourquin, Frédéric; Mendiratta, Shweta; Salamero, Jean; Géli, Vincent

    2016-01-01

    The nuclear pore complex (NPC) serves as both the unique gate between the nucleus and the cytoplasm and a major platform that coordinates nucleocytoplasmic exchanges, gene expression, and genome integrity. To understand how the NPC integrates these functional constraints, we dissected here the posttranslational modifications of the nuclear basket protein Nup60 and analyzed how they intervene to control the plasticity of the NPC. Combined approaches highlight the role of monoubiquitylation in regulating the association dynamics of Nup60 and its partner, Nup2, with the NPC through an interaction with Nup84, a component of the Y complex. Although major nuclear transport routes are not regulated by Nup60 modifications, monoubiquitylation of Nup60 is stimulated upon genotoxic stress and regulates the DNA-damage response and telomere repair. Together, these data reveal an original mechanism contributing to the plasticity of the NPC at a molecular-organization and functional level. PMID:26783300

  1. Posttranslational marks control architectural and functional plasticity of the nuclear pore complex basket.

    PubMed

    Niño, Carlos A; Guet, David; Gay, Alexandre; Brutus, Sergine; Jourquin, Frédéric; Mendiratta, Shweta; Salamero, Jean; Géli, Vincent; Dargemont, Catherine

    2016-01-18

    The nuclear pore complex (NPC) serves as both the unique gate between the nucleus and the cytoplasm and a major platform that coordinates nucleocytoplasmic exchanges, gene expression, and genome integrity. To understand how the NPC integrates these functional constraints, we dissected here the posttranslational modifications of the nuclear basket protein Nup60 and analyzed how they intervene to control the plasticity of the NPC. Combined approaches highlight the role of monoubiquitylation in regulating the association dynamics of Nup60 and its partner, Nup2, with the NPC through an interaction with Nup84, a component of the Y complex. Although major nuclear transport routes are not regulated by Nup60 modifications, monoubiquitylation of Nup60 is stimulated upon genotoxic stress and regulates the DNA-damage response and telomere repair. Together, these data reveal an original mechanism contributing to the plasticity of the NPC at a molecular-organization and functional level. PMID:26783300

  2. Supporting the President's Arms Control and Nonproliferation Agenda: Transparency and Verification for Nuclear Arms Reductions

    SciTech Connect

    Doyle, James E; Meek, Elizabeth

    2009-01-01

    The President's arms control and nonproliferation agenda is still evolving and the details of initiatives supporting it remain undefined. This means that DOE, NNSA, NA-20, NA-24 and the national laboratories can help define the agenda, and the policies and the initiatives to support it. This will require effective internal and interagency coordination. The arms control and nonproliferation agenda is broad and includes the path-breaking goal of creating conditions for the elimination of nuclear weapons. Responsibility for various elements of the agenda will be widely scattered across the interagency. Therefore an interagency mapping exercise should be performed to identify the key points of engagement within NNSA and other agencies for creating effective policy coordination mechanisms. These can include informal networks, working groups, coordinating committees, interagency task forces, etc. It will be important for NA-20 and NA-24 to get a seat at the table and a functional role in many of these coordinating bodies. The arms control and nonproliferation agenda comprises both mature and developing policy initiatives. The more mature elements such as CTBT ratification and a follow-on strategic nuclear arms treaty with Russia have defined milestones. However, recent press reports indicate that even the START follow-on strategic arms pact that is planned to be complete by the end of 2009 may take significantly longer and be more expansive in scope. The Russians called for proposals to count non-deployed as well as deployed warheads. Other elements of the agenda such as FMCT, future bilateral nuclear arms reductions following a START follow-on treaty, nuclear posture changes, preparations for an international nuclear security summit, strengthened international safeguards and multilateral verification are in much earlier stages of development. For this reason any survey of arms control capabilities within the USG should be structured to address potential needs across the

  3. Baseline Evaluations to Support Control Room Modernization at Nuclear Power Plants

    SciTech Connect

    Boring, Ronald L.; Joe, Jeffrey C.

    2015-02-01

    For any major control room modernization activity at a commercial nuclear power plant (NPP) in the U.S., a utility should carefully follow the four phases prescribed by the U.S. Nuclear Regulatory Commission in NUREG-0711, Human Factors Engineering Program Review Model. These four phases include Planning and Analysis, Design, Verification and Validation, and Implementation and Operation. While NUREG-0711 is a useful guideline, it is written primarily from the perspective of regulatory review, and it therefore does not provide a nuanced account of many of the steps the utility might undertake as part of control room modernization. The guideline is largely summative—intended to catalog final products—rather than formative—intended to guide the overall modernization process. In this paper, we highlight two crucial formative sub-elements of the Planning and Analysis phase specific to control room modernization that are not covered in NUREG-0711. These two sub-elements are the usability and ergonomics baseline evaluations. A baseline evaluation entails evaluating the system as-built and currently in use. The usability baseline evaluation provides key insights into operator performance using the control system currently in place. The ergonomics baseline evaluation identifies possible deficiencies in the physical configuration of the control system. Both baseline evaluations feed into the design of the replacement system and subsequent summative benchmarking activities that help ensure that control room modernization represents a successful evolution of the control system.

  4. Cellular microenvironment controls the nuclear architecture of breast epithelia through β1-integrin.

    PubMed

    Maya-Mendoza, Apolinar; Bartek, Jiri; Jackson, Dean A; Streuli, Charles H

    2016-02-01

    Defects in nuclear architecture occur in a variety of diseases, however the fundamental mechanisms that control the internal structure of nuclei are poorly defined. Here we reveal that the cellular microenvironment has a profound influence on the global internal organization of nuclei in breast epithelia. A 3D microenvironment induces a prolonged but reversible form of cell cycle arrest that features many of the classical markers of cell senescence. This unique form of arrest is dependent on signaling from the external microenvironment through β1-integrins. It is concomitant with alterations in nuclear architecture that characterize the withdrawal from cell proliferation. Unexpectedly, following prolonged cell cycle arrest in 3D, the senescence-like state and associated reprogramming of nuclear architecture are freely reversible on altering the dimensionality of the cellular microenvironment. Breast epithelia can therefore maintain a proliferative plasticity that correlates with nuclear remodelling. However, the changes in nuclear architecture are cell lineage-specific and do not occur in fibroblasts, and moreover they are overcome in breast cancer cells. PMID:26818565

  5. Dynamic nuclear polarization of {sup 29}Si nuclei in isotopically controlled phosphorus doped silicon

    SciTech Connect

    Hayashi, Hiroshi; Itahashi, Tatsumasa; Itoh, Kohei M.; Vlasenko, Leonid S.; Vlasenko, Marina P.

    2009-07-15

    Dynamic nuclear polarization (DNP) of {sup 29}Si nuclei in isotopically controlled silicon single crystals with the {sup 29}Si isotope abundance f{sub 29Si} varied from 1.2% to 99.2% is reported. It was found that both the DNP enhancement and {sup 29}Si nuclear spin-lattice relaxation time under saturation of the electron paramagnetic resonance transitions of phosphorus donors increase with the decrease in the {sup 29}Si abundance. A remarkably large steady-state DNP enhancement, E{sup ss}=2680 which is comparable to the theoretical upper limit of 3310, has been achieved through the ''resolved'' solid effect that has been identified clearly in the f{sub 29Si}=1.2% sample. The DNP enhancement depends not only on the {sup 29}Si abundance but also on the electron spin-lattice relaxation time that can be controlled by temperature and/or illumination. The linewidth of {sup 29}Si NMR spectra after DNP shows a linear dependence on f{sub 29Si} for f{sub 29Si}{<=}10% and changes to a square-root dependence for f{sub 29Si}{>=}50%. Comparison of experimentally determined nuclear polarization time with nuclear spin diffusion coefficients indicates that the rate of DNP is limited by the polarization transfer rather than by spin diffusion.

  6. Instrumentation and Control Needs for Reliable Operation of Lunar Base Surface Nuclear Power Systems

    NASA Technical Reports Server (NTRS)

    Turso, James; Chicatelli, Amy; Bajwa, Anupa

    2005-01-01

    As one of the near-term goals of the President's Vision for Space Exploration, establishment of a multi-person lunar base will require high-endurance power systems which are independent of the sun, and can operate without replenishment for several years. These requirements may be obtained using nuclear power systems specifically designed for use on the lunar surface. While it is envisioned that such a system will generally be supervised by humans, some of the evolutions required maybe semi or fully autonomous. The entire base complement for near-term missions may be less than 10 individuals, most or all of which may not be qualified nuclear plant operators and may be off-base for extended periods thus, the need for power system autonomous operation. Startup, shutdown, and load following operations will require the application of advanced control and health management strategies with an emphasis on robust, supervisory, coordinated control of, for example, the nuclear heat source, energy conversion plant (e.g., Brayton Energy Conversion units), and power management system. Autonomous operation implies that, in addition to being capable of automatic response to disturbance input or load changes, the system is also capable of assessing the status of the integrated plant, determining the risk associated with the possible actions, and making a decision as to the action that optimizes system performance while minimizing risk to the mission. Adapting the control to deviations from design conditions and degradation due to component failures will be essential to ensure base inhabitant safety and mission success. Intelligent decisions will have to be made to choose the right set of sensors to provide the data needed to do condition monitoring and fault detection and isolation because of liftoff weight and space limitations, it will not be possible to have an extensive set of instruments as used for earth-based systems. Advanced instrumentation and control technologies will be

  7. Lessons learned in digital upgrade projects digital control system implementation at US nuclear power stations

    SciTech Connect

    Kelley, S.; Bolian, T. W.

    2006-07-01

    AREVA NP has gained significant experience during the past five years in digital upgrades at operating nuclear power stations in the US. Plants are seeking modernization with digital technology to address obsolescence, spare parts availability, vendor support, increasing age-related failures and diminished reliability. New systems offer improved reliability and functionality, and decreased maintenance requirements. Significant lessons learned have been identified relating to the areas of licensing, equipment qualification, software quality assurance and other topics specific to digital controls. Digital control systems have been installed in non safety-related control applications at many utilities within the last 15 years. There have also been a few replacements of small safety-related systems with digital technology. Digital control systems are proving to be reliable, accurate, and easy to maintain. Digital technology is gaining acceptance and momentum with both utilities and regulatory agencies based upon the successes of these installations. Also, new plants are being designed with integrated digital control systems. To support plant life extension and address obsolescence of critical components, utilities are beginning to install digital technology for primary safety-system replacement. AREVA NP analyzed operating experience and lessons learned from its own digital upgrade projects as well as industry-wide experience to identify key issues that should be considered when implementing digital controls in nuclear power stations.

  8. Reliable Wireless Data Acquisition and Control Techniques within Nuclear Hot Cell Facilities

    SciTech Connect

    Kurtz, J.L.; Tulenko, J.

    2000-09-20

    On this NEER project the University of Florida has investigated and applied advanced communications techniques to address data acquisition and control problems within the Fuel Conditioning Facility (FCF) of Argonne National Laboratory-West (ANL-W) in Idaho Falls. The goals of this project have been to investigate and apply wireless communications techniques to solve the problem of communicating with and controlling equipment and systems within a nuclear hot cell facility with its attendant high radiation levels. Different wireless techniques, including radio frequency, infrared and power line communications were reviewed. For each technique, the challenges of radiation-hardened implementation were addressed. In addition, it has been a project goal to achieve the highest level of system reliability to ensure safe nuclear operations. Achievement of these goals would allow the eventual elimination of through-the-wall, hardwired cabling that is currently employed in the hot cell, along wit h all of the attendant problems that limit measurement mobility and flexibility.

  9. Production of an English/Russian glossary of terminology for nuclear materials control and accounting

    SciTech Connect

    Schachowskoj, S.; Smith, H.A. Jr.

    1995-05-01

    The program plans for Former Soviet Union National Nuclear Materials Control and Accounting (MC and A) Systems Enhancements call for the development of an English/Russian Glossary of MC and A terminology. This glossary was envisioned as an outgrowth of the many interactions, training sessions, and other talking and writing exercises that would transpire in the course of carrying out these programs. This report summarizes the status of the production of this glossary, the most recent copy of which is attached to this report. The glossary contains over 950 terms and acronyms associated with nuclear material control and accounting for safeguards and nonproliferation. This document is organized as follows: English/Russian glossary of terms and acronyms; Russian/English glossary of terms and acronyms; English/Russian glossary of acronyms; and Russian/English glossary of acronyms.

  10. Toward a livable world: Leo Szilard and the crusade for nuclear arms control

    SciTech Connect

    Szilard, L.

    1987-01-01

    Covering the years 1947 through 1963, this volume chronicles the physicist's attempts to influence public policy on arms control and disarmament issues. The book describes Szilard's opposition to antiballistic missile systems, his proposal for a Washington-Moscow ''hot line,'' his work in the Pugwash conference, his role in creating the Council for a Liveable World, his advocacy of no-first-use and restricted retaliation nuclear policies, and his support of ''minimum deterence'' in place of an overwhelming counterforce capability.

  11. Logical operations with single x-ray photons via dynamically-controlled nuclear resonances

    PubMed Central

    Gunst, Jonas; Keitel, Christoph H.; Pálffy, Adriana

    2016-01-01

    Photonic qubits lie at the heart of quantum information technology, often encoding information in their polarization state. So far, only low-frequency optical and infrared photons have been employed as flying qubits, as the resources that are at present easiest to control. With their essentially different way of interacting with matter, x-ray qubits would bear however relevant advantages: they are extremely robust, penetrate deep through materials, and can be focused down to few-nm waveguides, allowing unprecedented miniaturization. Also, x-rays are resonant to nuclear transitions, which are very well isolated from the environment and present long coherence times. Here, we show theoretically that x-ray polarization qubits can be dynamically controlled by nuclear Mössbauer resonances. The control knob is played by nuclear hyperfine magnetic fields, that allow via fast rotations precise processing of single x-ray quanta polarization. With such rotations, single-qubit and binary logical operations such as a destructive C-NOT gate can be implemented. PMID:27118340

  12. Logical operations with single x-ray photons via dynamically-controlled nuclear resonances

    NASA Astrophysics Data System (ADS)

    Gunst, Jonas; Keitel, Christoph H.; Pálffy, Adriana

    2016-04-01

    Photonic qubits lie at the heart of quantum information technology, often encoding information in their polarization state. So far, only low-frequency optical and infrared photons have been employed as flying qubits, as the resources that are at present easiest to control. With their essentially different way of interacting with matter, x-ray qubits would bear however relevant advantages: they are extremely robust, penetrate deep through materials, and can be focused down to few-nm waveguides, allowing unprecedented miniaturization. Also, x-rays are resonant to nuclear transitions, which are very well isolated from the environment and present long coherence times. Here, we show theoretically that x-ray polarization qubits can be dynamically controlled by nuclear Mössbauer resonances. The control knob is played by nuclear hyperfine magnetic fields, that allow via fast rotations precise processing of single x-ray quanta polarization. With such rotations, single-qubit and binary logical operations such as a destructive C-NOT gate can be implemented.

  13. Logical operations with single x-ray photons via dynamically-controlled nuclear resonances.

    PubMed

    Gunst, Jonas; Keitel, Christoph H; Pálffy, Adriana

    2016-01-01

    Photonic qubits lie at the heart of quantum information technology, often encoding information in their polarization state. So far, only low-frequency optical and infrared photons have been employed as flying qubits, as the resources that are at present easiest to control. With their essentially different way of interacting with matter, x-ray qubits would bear however relevant advantages: they are extremely robust, penetrate deep through materials, and can be focused down to few-nm waveguides, allowing unprecedented miniaturization. Also, x-rays are resonant to nuclear transitions, which are very well isolated from the environment and present long coherence times. Here, we show theoretically that x-ray polarization qubits can be dynamically controlled by nuclear Mössbauer resonances. The control knob is played by nuclear hyperfine magnetic fields, that allow via fast rotations precise processing of single x-ray quanta polarization. With such rotations, single-qubit and binary logical operations such as a destructive C-NOT gate can be implemented. PMID:27118340

  14. Domestic politics, citizen activism, and U. S. nuclear arms control policy

    SciTech Connect

    Knopf, J.W.

    1991-01-01

    The author seeks to ascertain whether and how citizens' movements concerning nuclear arms control and disarmament affect US arms control policy. The author employs a comparative case study methodology. He examines cases of the Eisenhower and Kennedy Administrations during the period of protest against nuclear testing, and the Reagan Administration during the nuclear weapons freeze campaign and the subsequent campaign for a comprehensive test ban. He hows there are four mechanisms through which public advocacy efforts can influence arms control policy, identifies the conditions under which each can be effective, and details the type of impact each mechanism has. Domestic activism interacts with broader public opinion in a way that creates electoral pressure; with elite-level debates in a way that removes a consensus behind presidential policy or changes the winning coalition in Congress; with bureaucratic politics, by generating ideas that have utility for some agents within the Executive; or with the public diplomacy of foreign governments, especially the Soviet Union. Citizens' movements had an impact on policy in each of the cases studied. The type and extent of impact, and the mechanisms involved in giving activism influence, are different for each case.

  15. Impact of the Fukushima nuclear accident on background radiation doses measured by control dosimeters in Japan.

    PubMed

    Romanyukha, Alexander; King, David L; Kennemur, Lisa K

    2012-05-01

    After the 9.0 magnitude earthquake and subsequent massive tsunami on 11 March 2011 in Japan, several reactors at the Fukushima Daiichi Nuclear Power Plant suffered severe damage. There was immediate participation of U.S. Navy vessels and other United States Department of Defense (DoD) teams that were already in the area at the time of the disaster or arrived shortly thereafter. The correct determination of occupational dose equivalent requires estimation of the background dose component measured by control dosimeters, which is subsequently subtracted from the total dose equivalent measured by personal dosimeters. The purpose of the control dosimeters is to determine the amount of radiation dose equivalent that has accumulated on the dosimeter from background or other non-occupational sources while they are in transit or being stored. Given the release of radioactive material and potential exposure to radiation from the Fukushima Daiichi Nuclear Power Plant and the process by which the U.S. Navy calculates occupational exposure to ionizing radiation, analysis of pre- and post-event control dosimeters is warranted. Several hundred historical dose records from the Naval Dosimetry Center (NDC) database were analyzed and compared with the post-accident dose equivalent data of control dosimeters. As result, it was shown that the dose contribution of the radiation and released radiological materials from the Fukushima nuclear accident to background radiation doses is less than 0.375 μSv d for shallow and deep photon dose equivalent. There is no measurable effect on neutron background exposure. The latter has at least two important conclusions. First, the NDC can use doses measured by control dosimeters at issuing sites in Japan for determination of personnel dose equivalents; second, the dose data from control dosimeters prior to and after the Fukushima accident may be used to assist in dose reconstruction of non-radiological (non-badged) personnel at these locations

  16. INDUSTRIAL CONTROL SYSTEM CYBER SECURITY: QUESTIONS AND ANSWERS RELEVANT TO NUCLEAR FACILITIES, SAFEGUARDS AND SECURITY

    SciTech Connect

    Robert S. Anderson; Mark Schanfein; Trond Bjornard; Paul Moskowitz

    2011-07-01

    Typical questions surrounding industrial control system (ICS) cyber security always lead back to: What could a cyber attack do to my system(s) and; how much should I worry about it? These two leading questions represent only a fraction of questions asked when discussing cyber security as it applies to any program, company, business, or organization. The intent of this paper is to open a dialog of important pertinent questions and answers that managers of nuclear facilities engaged in nuclear facility security and safeguards should examine, i.e., what questions should be asked; and how do the answers affect an organization's ability to effectively safeguard and secure nuclear material. When a cyber intrusion is reported, what does that mean? Can an intrusion be detected or go un-noticed? Are nuclear security or safeguards systems potentially vulnerable? What about the digital systems employed in process monitoring, and international safeguards? Organizations expend considerable efforts to ensure that their facilities can maintain continuity of operations against physical threats. However, cyber threats particularly on ICSs may not be well known or understood, and often do not receive adequate attention. With the disclosure of the Stuxnet virus that has recently attacked nuclear infrastructure, many organizations have recognized the need for an urgent interest in cyber attacks and defenses against them. Several questions arise including discussions about the insider threat, adequate cyber protections, program readiness, encryption, and many more. These questions, among others, are discussed so as to raise the awareness and shed light on ways to protect nuclear facilities and materials against such attacks.

  17. Review of Methods Related to Assessing Human Performance in Nuclear Power Plant Control Room Simulations

    SciTech Connect

    Katya L Le Blanc; Ronald L Boring; David I Gertman

    2001-11-01

    With the increased use of digital systems in Nuclear Power Plant (NPP) control rooms comes a need to thoroughly understand the human performance issues associated with digital systems. A common way to evaluate human performance is to test operators and crews in NPP control room simulators. However, it is often challenging to characterize human performance in meaningful ways when measuring performance in NPP control room simulations. A review of the literature in NPP simulator studies reveals a variety of ways to measure human performance in NPP control room simulations including direct observation, automated computer logging, recordings from physiological equipment, self-report techniques, protocol analysis and structured debriefs, and application of model-based evaluation. These methods and the particular measures used are summarized and evaluated.

  18. Nuclear Receptor DHR4 Controls the Timing of Steroid Hormone Pulses During Drosophila Development

    PubMed Central

    Ou, Qiuxiang; Magico, Adam; King-Jones, Kirst

    2011-01-01

    In insects, precisely timed periodic pulses of the molting hormone ecdysone control major developmental transitions such as molts and metamorphosis. The synthesis and release of ecdysone, a steroid hormone, is itself controlled by PTTH (prothoracicotopic hormone). PTTH transcript levels oscillate with an 8 h rhythm, but its significance regarding the timing of ecdysone pulses is unclear. PTTH acts on its target tissue, the prothoracic gland (PG), by activating the Ras/Raf/ERK pathway through its receptor Torso, however direct targets of this pathway have yet to be identified. Here, we demonstrate that Drosophila Hormone Receptor 4 (DHR4), a nuclear receptor, is a key target of the PTTH pathway and establishes temporal boundaries by terminating ecdysone pulses. Specifically, we show that DHR4 oscillates between the nucleus and cytoplasm of PG cells, and that the protein is absent from PG nuclei at developmental times when low titer ecdysone pulses occur. This oscillatory behavior is blocked when PTTH or torso function is abolished, resulting in nuclear accumulation of DHR4, while hyperactivating the PTTH pathway results in cytoplasmic retention of the protein. Increasing DHR4 levels in the PG can delay or arrest development. In contrast, reducing DHR4 function in the PG triggers accelerated development, which is caused by precocious ecdysone signaling due to a failure to repress ecdysone pulses. Finally, we show that DHR4 negatively regulates the expression of a hitherto uncharacterized cytochrome P450 gene, Cyp6t3. Disruption of Cyp6t3 function causes low ecdysteroid titers and results in heterochronic phenotypes and molting defects, indicating a novel role in the ecdysone biosynthesis pathway. We propose a model whereby nuclear DHR4 controls the duration of ecdysone pulses by negatively regulating ecdysone biosynthesis through repression of Cyp6t3, and that this repressive function is temporarily overturned via the PTTH pathway by removing DHR4 from the nuclear

  19. Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants.

    PubMed

    Assenholt, Jannie; Mouaikel, John; Andersen, Kasper R; Brodersen, Ditlev E; Libri, Domenico; Jensen, Torben Heick

    2008-11-01

    Production of aberrant messenger ribonucleoprotein particles (mRNPs) is subject to quality control (QC). In yeast strains carrying mutations of the THO complex, transcription induction triggers a number of interconnected QC phenotypes: (1) rapid degradation of several mRNAs; (2) retention of a fraction of THO-dependent mRNAs in transcription site-associated foci; and (3) formation of a high molecular weight DNA/protein complex in the 3'-ends of THO target genes. Here, we demonstrate that the 3'-5' exonucleolytic domain of the nuclear exosome factor Rrp6p is necessary for establishing all QC phenotypes associated with THO mutations. The N terminus of Rrp6p is also important presumably through its binding to the Rrp6p co-factor Rrp47p. Interestingly, the 3'-5' exonucleolytic activity of Dis3p, the only other active exonuclease of the nuclear exosome, can also contribute to RNA QC in THO mutants, while other nuclear 3'-5' exonucleases cannot. Our data show that exonucleolytic attack by the nuclear exosome is needed both for provoking mRNP QC and for its ensuing elimination of faulty RNA. PMID:18824516

  20. Experimental exploration over a quantum control landscape through nuclear magnetic resonance

    NASA Astrophysics Data System (ADS)

    Sun, Qiuyang; Pelczer, István; Riviello, Gregory; Wu, Re-Bing; Rabitz, Herschel

    2014-03-01

    The growing successes in performing quantum control experiments motivated the development of control landscape analysis as a basis to explain these findings. When a quantum system is controlled by an electromagnetic field, the observable as a functional of the control field forms a landscape. Theoretical analyses have revealed many properties of control landscapes, especially regarding their slopes, curvatures, and topologies. A full experimental assessment of the landscape predictions is important for future consideration of controlling quantum phenomena. Nuclear magnetic resonance (NMR) is exploited here as an ideal laboratory setting for quantitative testing of the landscape principles. The experiments are performed on a simple two-level proton system in a H2O-D2O sample. We report a variety of NMR experiments roving over the control landscape based on estimation of the gradient and Hessian, including ascent or descent of the landscape, level set exploration, and an assessment of the theoretical predictions on the structure of the Hessian. The experimental results are fully consistent with the theoretical predictions. The procedures employed in this study provide the basis for future multispin control landscape exploration where additional features are predicted to exist.

  1. Remote-Controlled Inspection Robot for Nuclear Facilities in Underwater Environment

    SciTech Connect

    Yasuhiro Miwa; Syuichi Satoh; Naoya Hirose

    2002-07-01

    A remote-controlled inspection robot for nuclear facilities was developed. This is a underwater robot technology combined with inspection and flaw removal technologies. This report will describe the structure and performance of this robot. The inspection robot consists of two parts. The one is driving equipment, and the other is inspection and grinding units. It can swim in the tank, move around the tank wall, and stay on the inspection area. After that it starts inspection and flaw removal with a special grinding wheel. This technology had been developed to inspect some Radioactive Waste (RW) tanks in operating nuclear power plants. There are many RW tanks in these plants, which human workers can be hard to access because of a high level dose. This technology is too useful for inspection works of human-inaccessible areas. And also, in conventional inspection process, some worker go into the tank and set up scaffolding after full drainage and decontamination. It spends too much time for these preparations. If tank inspection and flaw removal can be performed in underwater, the outage period will be reduced. Remote-controlled process can be performed in underwater. This is the great advantage for plant owners. Since 1999 we have been applying this inspection robot to operating nuclear 11 facilities in Japan. (authors)

  2. Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization

    PubMed Central

    Xu, Tao; Johnson, Cole A; Gestwicki, Jason E; Kumar, Anuj

    2016-01-01

    We present here a protocol to conditionally control the nuclear trafficking of target proteins in yeast. In this system, rapamycin is used to heterodimerize two chimeric proteins. one chimera consists of a FK506-binding protein (FKBp12) fused to a cellular ‘address’ (nuclear localization signal or nuclear export sequence). the second chimera consists of a target protein fused to a fluorescent protein and the FKBp12-rapamycin-binding (FrB) domain from FKBp-12-rapamycin associated protein 1 (Frap1, also known as mtor). rapamycin induces dimerization of the FKBp12- and FrB-containing chimeras; these interactions selectively place the target protein under control of the cell address, thereby directing the protein into or out of the nucleus. By chemical-induced dimerization, protein mislocalization is reversible and enables the identification of conditional loss-of-function and gain-of-function phenotypes, in contrast to other systems that require permanent modification of the targeted protein. Yeast strains for this analysis can be constructed in 1 week, and the technique allows protein mislocalization within 15 min after drug treatment. PMID:21030958

  3. 10 CFR 50.34a - Design objectives for equipment to control releases of radioactive material in effluents-nuclear...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Design objectives for equipment to control releases of radioactive material in effluents-nuclear power reactors. 50.34a Section 50.34a Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Applications for Licenses, Certifications, and Regulatory Approvals;...

  4. WTEC monograph on instrumentation, control and safety systems of Canadian nuclear facilities

    NASA Technical Reports Server (NTRS)

    Uhrig, Robert E.; Carter, Richard J.

    1993-01-01

    This report updates a 1989-90 survey of advanced instrumentation and controls (I&C) technologies and associated human factors issues in the U.S. and Canadian nuclear industries carried out by a team from Oak Ridge National Laboratory (Carter and Uhrig 1990). The authors found that the most advanced I&C systems are in the Canadian CANDU plants, where the newest plant (Darlington) has digital systems in almost 100 percent of its control systems and in over 70 percent of its plant protection system. Increased emphasis on human factors and cognitive science in modern control rooms has resulted in a reduced workload for the operators and the elimination of many human errors. Automation implemented through digital instrumentation and control is effectively changing the role of the operator to that of a systems manager. The hypothesis that properly introducing digital systems increases safety is supported by the Canadian experience. The performance of these digital systems has been achieved using appropriate quality assurance programs for both hardware and software development. Recent regulatory authority review of the development of safety-critical software has resulted in the creation of isolated software modules with well defined interfaces and more formal structure in the software generation. The ability of digital systems to detect impending failures and initiate a fail-safe action is a significant safety issue that should be of special interest to nuclear utilities and regulatory authorities around the world.

  5. Involvement of capsaicin-sensitive afferent nerves in the proteinase-activated receptor 2-mediated vasodilatation in the rat dura mater.

    PubMed

    Dux, M; Rosta, J; Sántha, P; Jancsó, G

    2009-07-01

    Neurogenic inflammation of the dura mater encephali has been suggested to contribute to the mechanisms of meningeal nociception and blood flow regulation. Recent findings demonstrated that the rat dura mater is innervated by trigeminal capsaicin-sensitive peptidergic nociceptive afferent nerves which mediate meningeal vascular responses through activation of the transient receptor potential vanilloid type 1 (TRPV1) receptor. The present work explored the functional significance of the capsaicin-sensitive subpopulation of dural afferent nerves via their contribution to the meningeal vascular responses evoked through activation of the proteinase-activated receptor 2 (PAR-2). The vascular responses of the dura mater were studied by laser Doppler flowmetry in a rat open cranial window preparation. Topical applications of trypsin, a PAR-2-activator, or Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH(2)), a selective PAR-2 agonist peptide, resulted in dose-dependent increases in meningeal blood flow. The SLIGRL-NH(2)-induced vasodilatation was significantly reduced following capsaicin-sensitive afferent nerve defunctionalization by prior systemic capsaicin treatment and by pretreatment of the dura mater with the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37). Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME) an unspecific inhibitor of nitric oxide (NO) production, but not 1-(2-trifluoromethylphenyl) imidazole (TRIM), a neuronal NO synthase inhibitor, also inhibited the vasodilator response to SLIGRL-NH(2). The vasodilator responses elicited by very low concentrations of capsaicin (10 nM) were significantly enhanced by prior application of SLIGRL-NH(2). The present findings demonstrate that activation of the PAR-2 localized on capsaicin-sensitive trigeminal nociceptive afferent nerves induces vasodilatation in the dural vascular bed by mechanisms involving NO and CGRP release. The results indicate that the PAR-2-mediated activation and

  6. Nuclear Rocket Test Facility Decommissioning Including Controlled Explosive Demolition of a Neutron-Activated Shield Wall

    SciTech Connect

    Michael Kruzic

    2007-09-01

    Located in Area 25 of the Nevada Test Site, the Test Cell A Facility was used in the 1960s for the testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program. The facility was decontaminated and decommissioned (D&D) in 2005 using the Streamlined Approach For Environmental Restoration (SAFER) process, under the Federal Facilities Agreement and Consent Order (FFACO). Utilities and process piping were verified void of contents, hazardous materials were removed, concrete with removable contamination decontaminated, large sections mechanically demolished, and the remaining five-foot, five-inch thick radiologically-activated reinforced concrete shield wall demolished using open-air controlled explosive demolition (CED). CED of the shield wall was closely monitored and resulted in no radiological exposure or atmospheric release.

  7. Radiation exposure control from the application of nuclear gauges in the mining industry in Ghana.

    PubMed

    Faanu, A; Darko, E O; Awudu, A R; Schandorf, C; Emi-Reynolds, G; Yeboah, J; Glover, E T; Kattah, V K

    2010-05-01

    The use of nuclear gauges for process control and elemental analysis in the mining industry in Ghana, West Africa, is wide spread and on the increase in recent times. The Ghana Radiation Protection Board regulates nuclear gauges through a system of notification and authorization by registration or licensing, inspection, and enforcement. Safety assessments for authorization and enforcement have been established to ensure the safety and security of radiation sources as well as protection of workers and the general public. Appropriate training of mine staff is part of the efforts to develop the necessary awareness about the safety and security of radiation sources. The knowledge and skills acquired will ensure the required protection and safety at the workplaces. Doses received by workers monitored over a period between 1998 and 2007 are well below the annual dose limit of 20 mSv recommended by the International Commission on Radiological Protection. PMID:20386190

  8. An electric heating control system for a nuclear power unit equipped with a fast-neutron reactor

    NASA Astrophysics Data System (ADS)

    Shmuel'Zon, M. B.; Barskii, L. A.

    2007-10-01

    An electric heating control system for a nuclear power unit equipped with a fast-neutron reactor is considered, which allows the required temperatures in the heat zones to be maintained when they are heated up and stabilized. The specific features of the controlled plant and the control equipment employed are taken into account.

  9. Spent Nuclear Fuel Project document control and Records Management Program Description

    SciTech Connect

    MARTIN, B.M.

    2000-05-18

    The Spent Nuclear Fuel (SNF) Project document control and records management program, as defined within this document, is based on a broad spectrum of regulatory requirements, Department of Energy (DOE) and Project Hanford and SNF Project-specific direction and guidance. The SNF Project Execution Plan, HNF-3552, requires the control of documents and management of records under the auspices of configuration control, conduct of operations, training, quality assurance, work control, records management, data management, engineering and design control, operational readiness review, and project management and turnover. Implementation of the controls, systems, and processes necessary to ensure compliance with applicable requirements is facilitated through plans, directives, and procedures within the Project Hanford Management System (PHMS) and the SNF Project internal technical and administrative procedures systems. The documents cited within this document are those which directly establish or define the SNF Project document control and records management program. There are many peripheral documents that establish requirements and provide direction pertinent to managing specific types of documents that, for the sake of brevity and clarity, are not cited within this document.

  10. Automated system for controlling authorization, identification, and entry into nuclear facilities

    SciTech Connect

    Barnes, L.D.

    1981-01-01

    An automated access control system developed at the Barnwell Nuclear Fuel Plant is described. This system enables the facility management to control who has access to sensitive areas at specific times, control the authority to grant access to individuals with cross-checks and verification, and provide positive identification of personnel obtaining entry, as well as an auditable record of all entry events. The individual seeking access enters his memorized identification number into a key pad in the entry booth. Positive verification of the identity claimed is obtained by a voice verification system which compares the sample response obtained at the time of entry with the individual's voice print reference file. The identified user is then issued a temporary proximity card key which will activate the door entry controls into authorized areas. The computerized system provides real-time entry inventory of personnel and controls individual area and personnel authorizations on a need-to-enter basis. The system was installed in 1979 and has been operated on a developmental basis since that time. The system controls access to an industrial area which has a total of fourteen separate and individually controlled subareas containing a combined total of twenty-four doors. Approximately five-hundred people are currently enrolled and using the system. Extended tests requiring 100% participation by employees are currently in progress.

  11. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

    PubMed

    Nguyen, Duy P; Miyaoka, Yuichiro; Gilbert, Luke A; Mayerl, Steven J; Lee, Brian H; Weissman, Jonathan S; Conklin, Bruce R; Wells, James A

    2016-01-01

    Cas9-based RNA-guided nuclease (RGN) has emerged to be a versatile method for genome editing due to the ease of construction of RGN reagents to target specific genomic sequences. The ability to control the activity of Cas9 with a high temporal resolution will facilitate tight regulation of genome editing processes for studying the dynamics of transcriptional regulation or epigenetic modifications in complex biological systems. Here we show that fusing ligand-binding domains of nuclear receptors to split Cas9 protein fragments can provide chemical control over split Cas9 activity. The method has allowed us to control Cas9 activity in a tunable manner with no significant background, which has been challenging for other inducible Cas9 constructs. We anticipate that our design will provide opportunities through the use of different ligand-binding domains to enable multiplexed genome regulation of endogenous genes in distinct loci through simultaneous chemical regulation of orthogonal Cas9 variants. PMID:27363581

  12. An expert system assistant to support the secondary side chemistry control of a nuclear reactor

    SciTech Connect

    Roberge, P.R.; Price, B.; Daniel, C.M.; Dymarski, M.J.

    1992-12-31

    The dynamic control of the water chemistry of the secondary side normally relies on sophisticated trend analysis of the various control and diagnostic parameters performed by a specialized technical person. In order to introduce into the control loop some elements of intelligence that escape traditional algorithms, a methodology had to be developed to care for the unforgivingness of computerized reasoning. The vast amount of information produced at nuclear power generating stations by the current addition of on-line analyzers can be managed by the implementation of what knowledge engineers call expert systems (ES). In order to make use of the numerous advantages ES offer over other methods which have traditionally been applied to perform preventive maintenance diagnosis the operational expertise had to be circumscribed and formatted the fit into the symbolic ES architecture.

  13. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity

    PubMed Central

    Nguyen, Duy P.; Miyaoka, Yuichiro; Gilbert, Luke A.; Mayerl, Steven J.; Lee, Brian H.; Weissman, Jonathan S.; Conklin, Bruce R.; Wells, James A.

    2016-01-01

    Cas9-based RNA-guided nuclease (RGN) has emerged to be a versatile method for genome editing due to the ease of construction of RGN reagents to target specific genomic sequences. The ability to control the activity of Cas9 with a high temporal resolution will facilitate tight regulation of genome editing processes for studying the dynamics of transcriptional regulation or epigenetic modifications in complex biological systems. Here we show that fusing ligand-binding domains of nuclear receptors to split Cas9 protein fragments can provide chemical control over split Cas9 activity. The method has allowed us to control Cas9 activity in a tunable manner with no significant background, which has been challenging for other inducible Cas9 constructs. We anticipate that our design will provide opportunities through the use of different ligand-binding domains to enable multiplexed genome regulation of endogenous genes in distinct loci through simultaneous chemical regulation of orthogonal Cas9 variants. PMID:27363581

  14. EARLY-STAGE DESIGN AND EVALUATION FOR NUCLEAR POWER PLANT CONTROL ROOM UPGRADES

    SciTech Connect

    Ronald L. Boring; Jeffrey C. Joe; Thomas A. Ulrich; Roger T. Lew

    2015-03-01

    As control rooms are modernized with new digital systems at nuclear power plants, it is necessary to evaluate operator performance with these systems as part of a verification and validation process. While there is regulatory and industry guidance for some modernization activities, there are no well defined standard processes or predefined metrics available for assessing what is satisfactory operator interaction with new systems, especially during the early design stages. This paper proposes a framework defining the design process and metrics for evaluating human system interfaces as part of control room modernization. The process and metrics are generalizable to other applications and serve as a guiding template for utilities undertaking their own control room modernization activities.

  15. Phosphorylation Controls the Nuclear-Cytoplasmic Shuttling of Influenza A Virus Nucleoprotein

    PubMed Central

    Zheng, Weinan; Li, Jing; Wang, Shanshan; Cao, Shuaishuai; Jiang, Jingwen; Chen, Can; Ding, Chan; Qin, Chuan; Ye, Xin; Gao, George F.

    2015-01-01

    ABSTRACT The nucleoprotein (NP) is a major component of the viral ribonucleoprotein (vRNP) complex. During the replication of influenza virus, the vRNP complex undergoes nuclear-cytoplasmic shuttling, during which NP serves as one of the determinants. To date, many phosphorylation sites on NP have been identified, but the biological functions of many of these phosphorylation sites remain unknown. In the present study, the functions of the phosphorylation sites S9, Y10, and Y296 were characterized. These residues are highly conserved, and their phosphorylation was essential for virus growth in cell culture and in a mouse model by regulating the activity of the viral polymerase and the nuclear-cytoplasmic shuttling of NP. The phosphorylation and dephosphorylation of S9 and Y10 controlled nuclear import of NP by affecting the binding affinity between NP and different isoforms of importin-α. In addition, the phosphorylation of Y296 caused nuclear retention of NP by reducing the interaction between NP and CRM1. Furthermore, tyrosine phosphorylation of NP during the early stage of virus infection was ablated when Y296 was mutated to F. However, at later stages of infection, it was weakened by the Y10F mutation. Taken together, the present data indicate that the phosphorylation and dephosphorylation of NP control the shuttling of NP between the nucleus and the cytoplasm during virus replication. IMPORTANCE It is well known that phosphorylation regulates the functions of viral proteins and the life cycle of influenza A virus. As NP is the most abundant protein in the vRNP complex of influenza A virus, several phosphorylation sites on this protein have been identified. However, the functions of these phosphorylation sites were unknown. The present study demonstrates that the phosphorylation status of these sites on NP can mediate its nuclear-cytoplasmic shuttling, which drives the trafficking of vRNP complexes in infected cells. The present data suggest that the

  16. Some possible applications of measurements on mu mesons to nuclear safeguards, nonproliferation, and arms control activities

    SciTech Connect

    Kane, W.R.; Vanier, P.E.

    1997-10-01

    In the nuclear safeguards and arms control areas, well-developed methodologies exist for determining the properties of nuclear materials via measurements of the gamma rays and neutrons emitted from these materials, or in the arms control area, by the use of radiography. In certain favorable instances, it may by feasible to perform comparable measurements with the use of a ubiquitous, naturally-occurring radiation--cosmic ray mu mesons (muons). At the earth`s surface these charged particles have a broad energy distribution peaking at about 500 MeV with a flux of approximately 10{sup {minus}2}/cm{sup 2}-sec-steradian. In traversing matter, muons lose energy at a rate of approximately 2 MeV/gram almost independent of atomic number. Muons can readily be detected by either plastic scintillators or wire planes. While the flux is small, a scintillator of one meter area, for example, will register about 20,000 events/min. these particles should have utility in the detection and imaging of objects with sectional densities of a few hundred grams/cm{sup 2}. The degree of intrusiveness of the imaging can be controlled through the detector configuration. Some possible applications include: (1) mass measurements on large UF{sub 6} cylinders, (2) determination of the size of treaty-limited objects, e.g., missiles, in rail cars or other containment; (3) verification of single or multiple warheads or components; (4) the detection of concealed, underground cavities. Examples will be presented.

  17. Biofouling monitoring and control program at the Boston Edison Pilgrim Nuclear Station: A twelve year history

    SciTech Connect

    McDonald, D.J.; Armstrong, W.J.; Carucci, C.A.

    1996-08-01

    This paper reviews the history of the Biofouling Monitoring and Control Program at the Boston Edison Company Pilgrim Nuclear Power Station. The program was initially developed in 1982 in response to serious operations, maintenance and performance related problems due to biofouling in both the circulating and service water systems. Although implemented seven years prior to federal mandates under GL 89-13, this program also satisfies regulatory criteria for biofouling monitoring and control of nuclear service water systems. Since its inception, the impact of macrofouling on plant operation and availability has been significantly reduced. Stringent monitoring for blue mussels, installation of mechanical barriers to horseshoe crabs, improvements in screens, screenwash and debris removal systems, and an on-going commitment to biofouling control have reduced the number of condenser backwashes per year from > 40 (1989) to < 10. Depending on conditions and timing of a backwash, the resulting economic gain from this improvement alone can be 1.5 to more than 4 million dollars a year. Other improvements in related components and the service water system have also resulted in reduced maintenance related problems and an additional cost benefit to the plant. 13 refs., 6 figs., 1 tab.

  18. Effect of Environmental Chemical Stress on Nuclear Noncoding RNA Involved in Epigenetic Control

    PubMed Central

    Arrigo, Patrizio; Pulliero, Alessandra

    2015-01-01

    In the last decade the role of noncoding RNAs (ncRNAs) emerges not only as key elements of posttranscriptional gene silencing, but also as important players of epigenetic regulation. New kind and new functions of ncRNAs are continuously discovered and one of their most important roles is the mediation of environmental signals, both physical and chemical. The activity of cytoplasmic short ncRNA is extensively studied, in spite of the fact that their function and role in the nuclear compartment are not yet completely unraveled. Cellular nucleus contains a multiplicity of long and short ncRNAs controlling at different levels transcriptional and epigenetic processes. In addition, some ncRNAs are involved in RNA editing and quality control. In this paper we review the existing knowledge dealing with how chemical stressors can influence the functionality of short nuclear ncRNAs. Furthermore, we perform bioinformatics analyses indicating that chemical environmental stressors not only induce DNA damage but also influence the mechanism of ncRNAs production and control. PMID:26339639

  19. Modal seismic analysis of a nuclear power plant control panel and comparison with SAP 4

    NASA Technical Reports Server (NTRS)

    Pamidi, M. R.; Pamidi, P. R.

    1976-01-01

    The application of NASTRAN to seismic analysis by considering the example of a nuclear power plant control panel was considered. A modal analysis of a three-dimensional model of the panel, consisting of beam and quadri-lateral membrane elements, is performed. Using the results of this analysis and a typical response spectrum of an earthquake, the seismic response of the structure is obtained. ALTERs required to the program in order to compute the maximum modal responses as well as the resultant response are given. The results are compared with those obtained by using the SAP IV computer program.

  20. Upgrade of the Nuclear Material Protection, Control and Accounting System at the VNIIEF Industrial Zone

    SciTech Connect

    Lewis, J.C.; Maltsev, V.; Singh, S.P.

    1999-09-20

    The Industrial Zone at the Russian Federal Nuclear Center/All-Russian Scientific Research Institute of Experimental Physics (RFNC/VNEEF) consists of ten guarded areas with twenty two material balance areas (A and As). The type of facilities in the Industrial Zone include storage sites, machine shops, research facilities, and training facilities. Modernization of the Material Protection, Control and Accounting (MPC and A) System at the Industrial Zone started in 1997. This paper provides a description of, the methodology/strategy used in the upgrade of the MFC and A system.

  1. The applicability of sample collection and analysis in support of nuclear arms control agreements

    SciTech Connect

    McGuire, R.R.

    1995-08-01

    Agreements are being negotiated to halt the spread of nuclear arms both within the declared nuclear weapons states and to states not heretofore declaring their possession. With the verification regime of the recently negotiated Chemical Weapons Convention (CWC) as a model, negotiators are considering variations of on-site inspection as formulas to enhance the assurance of compliance with future agreements. These on-site inspections may be part of a treaty dictated verification regime or one of a set of voluntary {open_quotes}confidence building{close_quotes} measures. In either case, the collection of material samples for analysis could be an integral component of the inspection as it is in the CWC. The following is an assessment of the applicability of sampling and analysis for compliance monitoring nuclear arms control agreements currently envisioned. There are two essentially orthogonal ways of approaching this question of applicability: the consideration of the analytical questions and the consideration of the specifics of the individual agreements. This study is meant to utilize both approaches in examining the possible impact of sampling and analysis on compliance assessment. First attention must be given to technical questions relating to the efficacy of sampling and analysis.

  2. Multiple Unit Instrumentation and Control (I and C) Systems for Generation IV Nuclear Power Systems

    SciTech Connect

    Miller, Don W.; Fiorino, Michael M.; Quinn, Edward 'Ted'; Mauck, Jerry L.

    2002-07-01

    Several Generation IV design concepts involve compact modular reactor configurations that can significantly reduce the overall cost of construction of a nuclear plant. However, the operating costs of independent smaller units are increased on a per-MW basis versus larger scale reactors. To offset this economic penalty, Generation IV nuclear plants will benefit economically from a multi-unit (or multi-module) configuration, where some facilities or power conversion system resources are shared; balance of plant systems, auxiliary systems, and the main control room are all candidates for shared or integrated implementation. However, these multi-modular configurations introduce safety and operational challenges that must be addressed at an early stage in the design process. The goal of this paper is the identification and evaluation of the regulatory, operational, and monitoring issues arising from multi-unit nuclear plant implementations. The paper will provide an overview of a research approach that uses a model of a generic module as a basis for integration of design and monitoring, alongside regulatory requirements, for these proposed configurations. (authors)

  3. The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization.

    PubMed

    Atencio, David; Barnes, Cassandra; Duncan, Thomas M; Willis, Ian M; Hanes, Steven D

    2014-03-01

    The Ess1 prolyl isomerase from Saccharomyces cerevisiae and its human ortholog, Pin1, play critical roles in transcription by regulating RNA polymerase II. In human cells, Pin1 also regulates a variety of signaling proteins, and Pin1 misexpression is linked to several human diseases. To gain insight into Ess1/Pin1 function, we carried out a synthetic genetic array screen to identify novel targets of Ess1 in yeast. We identified potential targets of Ess1 in transcription, stress, and cell-cycle pathways. We focused on the cell-cycle regulators Swi6 and Whi5, both of which show highly regulated nucleocytoplasmic shuttling during the cell cycle. Surprisingly, Ess1 did not control their transcription but instead was necessary for their nuclear localization. Ess1 associated with Swi6 and Whi5 in vivo and bound directly to peptides corresponding to their nuclear localization sequences in vitro. Binding by Ess1 was significant only if the Swi6 and Whi5 peptides were phosphorylated at Ser-Pro motifs, the target sites of cyclin-dependent kinases. On the basis of these results, we propose a model in which Ess1 induces a conformational switch (cis-trans isomerization) at phospho-Ser-Pro sites within the nuclear targeting sequences of Swi6 and Whi5. This switch would promote nuclear entry and/or retention during late M and G1 phases and might work by stimulating dephosphorylation at these sites by the Cdc14 phosphatase. This is the first study to identify targets of Ess1 in yeast other than RNA polymerase II. PMID:24470217

  4. Advanced Outage and Control Center: Strategies for Nuclear Plant Outage Work Status Capabilities

    SciTech Connect

    Gregory Weatherby

    2012-05-01

    The research effort is a part of the Light Water Reactor Sustainability (LWRS) Program. LWRS is a research and development program sponsored by the Department of Energy, performed in close collaboration with industry to provide the technical foundations for licensing and managing the long-term, safe and economical operation of current nuclear power plants. The LWRS Program serves to help the US nuclear industry adopt new technologies and engineering solutions that facilitate the continued safe operation of the plants and extension of the current operating licenses. The Outage Control Center (OCC) Pilot Project was directed at carrying out the applied research for development and pilot of technology designed to enhance safe outage and maintenance operations, improve human performance and reliability, increase overall operational efficiency, and improve plant status control. Plant outage management is a high priority concern for the nuclear industry from cost and safety perspectives. Unfortunately, many of the underlying technologies supporting outage control are the same as those used in the 1980’s. They depend heavily upon large teams of staff, multiple work and coordination locations, and manual administrative actions that require large amounts of paper. Previous work in human reliability analysis suggests that many repetitive tasks, including paper work tasks, may have a failure rate of 1.0E-3 or higher (Gertman, 1996). With between 10,000 and 45,000 subtasks being performed during an outage (Gomes, 1996), the opportunity for human error of some consequence is a realistic concern. Although a number of factors exist that can make these errors recoverable, reducing and effectively coordinating the sheer number of tasks to be performed, particularly those that are error prone, has the potential to enhance outage efficiency and safety. Additionally, outage management requires precise coordination of work groups that do not always share similar objectives. Outage

  5. Digital control systems in nuclear power plants: Failure information, modeling concepts, and applications

    SciTech Connect

    Galyean, W.J.

    1993-06-23

    This report briefly describes some current applications of advanced computerized digital display and control systems at US commercial nuclear power plants and presents the results of a literature search that was made to gather information on the reliability of these systems. Both hardware and software reliability were addressed in this review. Only limited failure rate information was found, with the chemical process industry being the primary source of information on hardware failure rates and expert opinion the primary source for software failure rates. Safety-grade digital control systems are typically installed on a functional like-for-like basis, replacing older analog systems without substantially changing interactions with other plant systems. Future work includes performing a limited probabilistic risk assessment of a representative DCS to assess its risk significance.

  6. Digital control systems in nuclear power plants: Failure information, modeling concepts, and applications. Revision 1

    SciTech Connect

    Galyean, W.J.

    1993-06-23

    This report briefly describes some current applications of advanced computerized digital display and control systems at US commercial nuclear power plants and presents the results of a literature search that was made to gather information on the reliability of these systems. Both hardware and software reliability were addressed in this review. Only limited failure rate information was found, with the chemical process industry being the primary source of information on hardware failure rates and expert opinion the primary source for software failure rates. Safety-grade digital control systems are typically installed on a functional like-for-like basis, replacing older analog systems without substantially changing interactions with other plant systems. Future work includes performing a limited probabilistic risk assessment of a representative DCS to assess its risk significance.

  7. Method and means for remote removal of guide balls from nuclear reactor control rods

    SciTech Connect

    Krieg, A.H.

    1988-11-29

    This patent describes a method of remotely removing guide balls from nuclear reactor control rods using a punch mechanism, comprising: (a) providing attachment means in the punch mechanism for attaching the punch mechanism to means for reversibly lowering the punch mechanism over the top of one of the control rods; (b) providing a die within the punch mechanism; (c) providing cylinder means within the punch mechanism operatively connected to the die for axially moving the die in a back-and-forth direction; (d) providing a die block within the punch mechanism cooperating with the die; (e) providing guide means within the punch mechanism for self-aligning the punch mechanism so that the die and the die block are automatically aligned with a first one of the guide balls therebetween when the punch mechanism is lowered over the top of the control rod; (f) lowering the punch mechanism over the control rod so that the die, the die block, and the first guide ball are in alignment; and (g) then operating the cylinder means so that the die advances into the die block, thereby removing the first guide ball from the control rod.

  8. Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

    NASA Astrophysics Data System (ADS)

    Vinding, Mads S.; Laustsen, Christoffer; Maximov, Ivan I.; Søgaard, Lise Vejby; Ardenkjær-Larsen, Jan H.; Nielsen, Niels Chr.

    2013-02-01

    Aimed at 13C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-13C]pyruvate on a 4.7 T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.

  9. Upgrade of Control and Protection System of the Ignalina Nuclear Power Plant Units 1 and 2

    SciTech Connect

    Wright, Ronald E.; Fletcher, Norman; Pearsall, Raymond; Sidnev, Victor; Bickel, John; Vianello, Aldo

    2003-08-01

    The Ignalina Nuclear Power Plant (NPP) Units 1 and 2 are Soviet-designed, RBMK (Reaktor Bolshoi Moschnosti Kipyashchiy), channelized, large power-type reactors. The original-design electrical capacity for each unit was 1500 Megawatts. Unit 1 began operating in 1983, and Unit 2 was started up in 1987. In 1994, the government of Lithuania agreed to accept grant support for the Ignalina NPP Safety Improvement Program with funding supplied by the Nuclear Safety Account of the European Bank for Reconstruction and Development (EBRD). As conditions for receiving this funding, Ignalina NPP agreed to prepare a comprehensive Safety Analysis Report that would undergo independent peer review after it was issued. The EBRD Safety Panel oversaw preparation and review of the report. In 1996, the Safety Analysis Report for Unit 1 was completed and delivered to the EBRD. Part of the analyses covered anticipated transients without scram (ATWS). The analysis showed that some ATWS scenarios could lead to unacceptable consequences in less than a minute. The EBRD Safety Panel recommended to the Government of Lithuania that Ignalina NPP develop and implement a Program of Compensatory Measures for the Control and Protection System before the unit would be allowed to return to operation following its 1998 maintenance outage. A compensatory control and protection system that would mitigate the unacceptable consequences was designed, procured, manufactured, tested, and installed. The project was funded by U.S. Department of Energy.

  10. Local cerebral hyperthermia induces spontaneous thrombosis and arteriolar constriction in the pia mater of the mouse

    NASA Astrophysics Data System (ADS)

    El-Sabban, Farouk; Fahim, Mohamed A.

    1995-06-01

    The effect of local cerebral hyperthermia on responses of pial microvessels of the mouse was investigated. A set protocol was followed, involving the performance of a craniotomy on anaesthetized animals and using intravital microscope-television closed circuitry. Controlled hyperthermic exposure was applied regionally by heating the brain surface with irrigating artificial cerebrospinal fluid. Microvascular responses such as changes in diameter, thrombosis and embolism were monitored and video-taped observations were further viewed and analysed. When both brain surface and core body temperatures were kept at 37° C, no changes in pial microvessels were noted. With core body temperature kept at 37° C and at a brain surface temperature of 43.1° C, passing emboli and arteriolar constriction were observed. A few minutes later, visible thrombosis was prevalent. Further spontaneous thrombo-embolic activity continued and at the end of a 50-min hyperthermic exposure, arterioles attained a constriction of 37%. Thrombus formation was sometimes massive enough to occlude fully the microvessel. The protocol followed in this study can be adopted to other small animal species and for a variety of experimental procedures involving hyperthermia and the pial microcirculation.

  11. Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control

    PubMed Central

    Lelièvre, Sophie A.

    2009-01-01

    Post-translational modification of histones, ATP-dependent chromatin remodeling, and DNA methylation are interconnected nuclear mechanisms that ultimately lead to the changes in chromatin structure necessary to carry out epigenetic gene expression control. Tissue differentiation is characterized by a specific gene expression profile in association with the acquisition of a defined tissue architecture and function. Elements critical for tissue differentiation, like extracellular stimuli, adhesion and cell shape properties, and transcription factors all contribute to the modulation of gene expression and thus, are likely to impinge on the nuclear mechanisms of epigenetic gene expression control. In this review, we analyze how these elements modify chromatin structure in a hierarchical manner by acting on the nuclear machinery. We discuss how mechanotransduction via the structural continuum of the cell and biochemical signaling to the cell nucleus integrate to provide a comprehensive control of gene expression. The role of nuclear organization in this control is highlighted, with a presentation of differentiation-induced nuclear structure and the concept of nuclear organization as a modulator of the response to incoming signals. PMID:19328836

  12. Strategy for Migration of Traditional to Hybrid Control Boards in a Nuclear Power Plant

    SciTech Connect

    Boring, Ronald Laurids; Joe, Jeffrey Clark; Ulrich, Thomas Anthony

    2014-07-01

    This strategy document describes the NUREG-0711 based human factors engineering (HFE) phases and associated elements required to support design, verification and validation (V&V), and implementation of new digital control room elements in a legacy analog main control room (MCR). Information from previous planning and analysis work serves as the foundation for creating a human-machine interface (HMI) specification for distributed control systems (DCSs) to be implemented as part of nuclear power plant (NPP) modernization. This document reviews ways to take the HMSI specification and use it when migrating legacy displays or designing displays with new functionality. These displays undergo iterative usability testing during the design phase and then an integrated system validation (ISV) in the full-scope control room training simulator. Following successful demonstration of operator performance using the systems during the ISV, the new DCS is implemented at the plant, first in the training simulator and then in the MCR. This document concludes with a sample project plan, including a 15-month timeline from DCS design through implementation. Included is a discussion of how the U.S. Department of Energy’s Human System Simulation Laboratory (HSSL) can be used to support design and V&V activities. This report completes a Level 4 (M4) milestone under the U.S. Department of Energy’s (DOE’s) Light Water Reactor Sustainability (LWRS) Program.

  13. Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells

    PubMed Central

    Niopek, Dominik; Benzinger, Dirk; Roensch, Julia; Draebing, Thomas; Wehler, Pierre; Eils, Roland; Di Ventura, Barbara

    2014-01-01

    The function of many eukaryotic proteins is regulated by highly dynamic changes in their nucleocytoplasmic distribution. The ability to precisely and reversibly control nuclear translocation would, therefore, allow dissecting and engineering cellular networks. Here we develop a genetically encoded, light-inducible nuclear localization signal (LINuS) based on the LOV2 domain of Avena sativa phototropin 1. LINuS is a small, versatile tag, customizable for different proteins and cell types. LINuS-mediated nuclear import is fast and reversible, and can be tuned at different levels, for instance, by introducing mutations that alter AsLOV2 domain photo-caging properties or by selecting nuclear localization signals (NLSs) of various strengths. We demonstrate the utility of LINuS in mammalian cells by controlling gene expression and entry into mitosis with blue light. PMID:25019686

  14. Nuclear Rocket Facility Decommissioning Project: Controlled Explosive Demolition of Neutron Activated Shield Wall

    SciTech Connect

    Michael R. Kruzic

    2007-09-16

    Located in Area 25 of the Nevada Test Site (NTS), the Test Cell A (TCA) Facility was used in the early to mid-1960s for the testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program, to further space travel. Nuclear rocket testing resulted in the activation of materials around the reactors and the release of fission products and fuel particles in the immediate area. Identified as Corrective Action Unit 115, the TCA facility was decontaminated and decommissioned (D&D) from December 2004 to July 2005 using the Streamlined Approach for Environmental Restoration (SAFER) process, under the ''Federal Facility Agreement and Consent Order''. The SAFER process allows environmental remediation and facility closure activities (i.e., decommissioning) to occur simultaneously provided technical decisions are made by an experienced decision maker within the site conceptual site model, identified in the Data Quality Objective process. Facility closure involved a seven-step decommissioning strategy. Key lessons learned from the project included: (1) Targeted preliminary investigation activities provided a more solid technical approach, reduced surprises and scope creep, and made the working environment safer for the D&D worker. (2) Early identification of risks and uncertainties provided opportunities for risk management and mitigation planning to address challenges and unanticipated conditions. (3) Team reviews provided an excellent mechanism to consider all aspects of the task, integrated safety into activity performance, increase team unity and ''buy-in'' and promoted innovative and time saving ideas. (4) Development of CED protocols ensured safety and control. (5) The same proven D&D strategy is now being employed on the larger ''sister'' facility, Test Cell C.

  15. Multiple phosphorylation events control chicken ovalbumin upstream promoter transcription factor I orphan nuclear receptor activity.

    PubMed

    Gay, Frédérique; Baráth, Peter; Desbois-Le Péron, Christine; Métivier, Raphaël; Le Guével, Rémy; Birse, Darcy; Salbert, Gilles

    2002-06-01

    Chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) is an orphan member of the nuclear hormone receptor superfamily that comprises key regulators of many biological functions, such as embryonic development, metabolism, homeostasis, and reproduction. Although COUP-TFI can both actively silence gene transcription and antagonize the functions of various other nuclear receptors, the COUP-TFI orphan receptor also acts as a transcriptional activator in certain contexts. Moreover, COUP-TFI has recently been shown to serve as an accessory factor for some ligand-bound nuclear receptors, suggesting that it may modulate, both negatively and positively, a wide range of hormonal responses. In the absence of any identified cognate ligand, the mechanisms involved in the regulation of COUP-TFI activity remain unclear. The elucidation of several putative phosphorylation sites for MAPKs, PKC, and casein kinase II within the sequence of this orphan receptor led us to investigate phosphorylation events regulating the various COUP-TFI functions. After showing that COUP-TFI is phosphorylated in vivo, we provide evidence that in vivo inhibition of either MAPK or PKC signaling pathway leads to a specific and pronounced decrease in COUP-TFI-dependent transcriptional activation of the vitronectin gene promoter. Focusing on the molecular mechanisms underlying the MAPK- and PKC-mediated regulation of COUP-TFI activity, we show that COUP-TFI can be directly targeted by PKC and MAPK. These phosphorylation events differentially modulate COUP-TFI functions: PKC-mediated phosphorylation enhances COUP-TFI affinity for DNA and MAPK-mediated phosphorylation positively regulates the transactivation function of COUP-TFI, possibly through enhancing specific coactivator recruitment. These data provide evidence that COUP-TFI is likely to integrate distinct signaling pathways and raise the possibility that multiple extracellular signals influence biological processes controlled by COUP

  16. Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis

    PubMed Central

    Hu, Ying; Chau, Thinh; Liu, Hui-xin; Liao, Degui; Keane, Ryan; Nie, Yuqiang; Yang, Hui; Wan, Yu-Jui Yvonne

    2014-01-01

    Bile acids (BAs) are endogenous agents capable of causing cancer throughout the gastrointestinal (GI) tract. To uncover the mechanism by which BAs exert carcinogenic effects, both human liver and colon cancer cells as well as mouse primary hepatocytes were treated with BAs and assayed for viability, genotoxic stress, and transcriptional response. BAs induced both Nur77 (NR4A1) and pro-inflammatory gene expression. The intracellular location of BA-induced Nur77 was time-dependent; short-term (1–3 h) exposure induced nuclear Nur77 whereas longer (1–2 days) exposure also increased cytosolic Nur77 expression and apoptosis. Inhibiting Nur77 nuclear export with leptomycin B decreased LCA-induced apoptosis. Extended (7 days) treatment with BA generated resistance to BA with increased nuclear Nur77, viability, and mobility. While, knockdown of Nur77 in BA-resistant cells increased cellular susceptibility to LCA-induced apoptosis. Moreover, in vivo mouse xenograft experiments demonstrated that BA-resistant cells form larger tumors with elevated Nur77 expression compared to parental controls. DNA-binding and gene expression assays identified multiple survival genes (CDK4, CCND2, MAP4K5, STAT5A, and RBBP8) and a pro-apoptosis gene (BID) as Nur77 targets. Consistently, BA-induced up-regulation of the aforementioned genes was abrogated by a lack of Nur77. Importantly, Nur77 was overexpressed in high percentage of human colon and liver cancer specimens and the intracellular location of Nur77 correlated with elevated serum total BA levels in colon cancer patients. These data show for the first time that BAs via Nur77 have a dual role in modulating cell survival and death. Implications: These findings establish a direct link between Nur77 and the carcinogenic effect of bile acids. PMID:25232032

  17. CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state

    PubMed Central

    Gascoigne, Karen E.

    2013-01-01

    Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex. Prior work has identified more than 100 different kinetochore components in human cells. However, little is known about the regulatory processes that specify their assembly upon mitotic entry and disassembly at mitotic exit. In this paper, we used a live-cell imaging–based assay to quantify kinetochore disassembly kinetics and systematically analyze the role of potential regulatory mechanisms in controlling kinetochore assembly state. We find that kinetochore assembly and disassembly was driven primarily by mitotic phosphorylation downstream of cyclin-dependent kinase (CDK). In addition, we demonstrate that nuclear exclusion of the Ndc80 complex helped restrict kinetochore formation to mitosis. Combining constitutive CDK-dependent phosphorylation of CENP-T and forced nuclear localization of the Ndc80 complex partially prevented kinetochore disassembly at mitotic exit and led to chromosome segregation defects in subsequent divisions. In total, we find that the coordinated temporal regulation of outer kinetochore assembly is essential for accurate cell division. PMID:23530067

  18. Investigation of criticality safety control infraction data at a nuclear facility

    SciTech Connect

    Cournoyer, Michael E.; Merhege, James F.; Costa, David A.; Art, Blair M.; Gubernatis, David C.

    2014-10-27

    Chemical and metallurgical operations involving plutonium and other nuclear materials account for most activities performed at the LANL's Plutonium Facility (PF-4). The presence of large quantities of fissile materials in numerous forms at PF-4 makes it necessary to maintain an active criticality safety program. The LANL Nuclear Criticality Safety (NCS) Program provides guidance to enable efficient operations while ensuring prevention of criticality accidents in the handling, storing, processing and transportation of fissionable material at PF-4. In order to achieve and sustain lower criticality safety control infraction (CSCI) rates, PF-4 operations are continuously improved, through the use of Lean Manufacturing and Six Sigma (LSS) business practices. Employing LSS, statistically significant variations (trends) can be identified in PF-4 CSCI reports. In this study, trends have been identified in the NCS Program using the NCS Database. An output metric has been developed that measures ADPSM Management progress toward meeting its NCS objectives and goals. Using a Pareto Chart, the primary CSCI attributes have been determined in order of those requiring the most management support. Data generated from analysis of CSCI data help identify and reduce number of corresponding attributes. In-field monitoring of CSCI's contribute to an organization's scientific and technological excellence by providing information that can be used to improve criticality safety operation safety. This increases technical knowledge and augments operational safety.

  19. Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1

    SciTech Connect

    Hoppe, George . E-mail: hoppeg@ccf.org; Talcott, Katherine E.; Bhattacharya, Sanjoy K.; Crabb, John W.; Sears, Jonathan E.

    2006-11-01

    Oxidative stress can induce a covalent disulfide bond between protein and peptide thiols that is reversible through enzymatic catalysis. This process provides a post-translational mechanism for control of protein function and may also protect thiol groups from irreversible oxidation. High mobility group protein B1 (Hmgb1), a DNA-binding structural chromosomal protein and transcriptional co-activator was identified as a substrate of glutaredoxin. Hmgb1 contains 3 cysteines, Cys23, 45, and 106. In mild oxidative conditions, Cys23 and Cys45 readily form an intramolecular disulfide bridge, whereas Cys106 remains in the reduced form. The disulfide bond between Cys23 and Cys45 is a target of glutathione-dependent reduction by glutaredoxin. Endogenous Hmgb1 as well as GFP-tagged wild-type Hmgb1 co-localize in the nucleus of CHO cells. While replacement of Hmgb1 Cys23 and/or 45 with serines did not affect the nuclear distribution of the mutant proteins, Cys106-to-Ser and triple cysteine mutations impaired nuclear localization of Hmgb1. Our cysteine targeted mutational analysis suggests that Cys23 and 45 induce conformational changes in response to oxidative stress, whereas Cys106 appears to be critical for the nucleocytoplasmic shuttling of Hmgb1.

  20. Investigation of criticality safety control infraction data at a nuclear facility

    DOE PAGESBeta

    Cournoyer, Michael E.; Merhege, James F.; Costa, David A.; Art, Blair M.; Gubernatis, David C.

    2014-10-27

    Chemical and metallurgical operations involving plutonium and other nuclear materials account for most activities performed at the LANL's Plutonium Facility (PF-4). The presence of large quantities of fissile materials in numerous forms at PF-4 makes it necessary to maintain an active criticality safety program. The LANL Nuclear Criticality Safety (NCS) Program provides guidance to enable efficient operations while ensuring prevention of criticality accidents in the handling, storing, processing and transportation of fissionable material at PF-4. In order to achieve and sustain lower criticality safety control infraction (CSCI) rates, PF-4 operations are continuously improved, through the use of Lean Manufacturing andmore » Six Sigma (LSS) business practices. Employing LSS, statistically significant variations (trends) can be identified in PF-4 CSCI reports. In this study, trends have been identified in the NCS Program using the NCS Database. An output metric has been developed that measures ADPSM Management progress toward meeting its NCS objectives and goals. Using a Pareto Chart, the primary CSCI attributes have been determined in order of those requiring the most management support. Data generated from analysis of CSCI data help identify and reduce number of corresponding attributes. In-field monitoring of CSCI's contribute to an organization's scientific and technological excellence by providing information that can be used to improve criticality safety operation safety. This increases technical knowledge and augments operational safety.« less

  1. Medical Image Processing Server applied to Quality Control of Nuclear Medicine.

    NASA Astrophysics Data System (ADS)

    Vergara, C.; Graffigna, J. P.; Marino, E.; Omati, S.; Holleywell, P.

    2016-04-01

    This paper is framed within the area of medical image processing and aims to present the process of installation, configuration and implementation of a processing server of medical images (MIPS) in the Fundación Escuela de Medicina Nuclear located in Mendoza, Argentina (FUESMEN). It has been developed in the Gabinete de Tecnologia Médica (GA.TE.ME), Facultad de Ingeniería-Universidad Nacional de San Juan. MIPS is a software that using the DICOM standard, can receive medical imaging studies of different modalities or viewing stations, then it executes algorithms and finally returns the results to other devices. To achieve the objectives previously mentioned, preliminary tests were conducted in the laboratory. More over, tools were remotely installed in clinical enviroment. The appropiate protocols for setting up and using them in different services were established once defined those suitable algorithms. Finally, it’s important to focus on the implementation and training that is provided in FUESMEN, using nuclear medicine quality control processes. Results on implementation are exposed in this work.

  2. Control of nuclear activities by substrate-selective and protein-group SUMOylation.

    PubMed

    Jentsch, Stefan; Psakhye, Ivan

    2013-01-01

    Reversible modification of proteins by SUMO (small ubiquitin-like modifier) affects a large number of cellular processes. In striking contrast to the related ubiquitin pathway, only a few enzymes participate in the SUMO system, although this pathway has numerous substrates as well. Emerging evidence suggests that SUMOylation frequently targets entire groups of physically interacting proteins rather than individual proteins. Protein-group SUMOylation appears to be triggered by recruitment of SUMO ligases to preassembled protein complexes. Because SUMOylation typically affects groups of proteins that bear SUMO-interaction motifs (SIMs), protein-group SUMOylation may foster physical interactions between proteins through multiple SUMO-SIM interactions. Individual SUMO modifications may act redundantly or additively, yet they may mediate dedicated functions as well. In this review, we focus on the unorthodox principles of this pathway and give examples for SUMO-controlled nuclear activities. We propose that collective SUMOylation is typical for nuclear assemblies and argue that SUMO serves as a distinguishing mark for functionally engaged protein fractions. PMID:24016193

  3. Drosophila dany is essential for transcriptional control and nuclear architecture in spermatocytes.

    PubMed

    Trost, Martina; Blattner, Ariane C; Leo, Stefano; Lehner, Christian F

    2016-07-15

    The terminal differentiation of adult stem cell progeny depends on transcriptional control. A dramatic change in gene expression programs accompanies the transition from proliferating spermatogonia to postmitotic spermatocytes, which prepare for meiosis and subsequent spermiogenesis. More than a thousand spermatocyte-specific genes are transcriptionally activated in early Drosophila spermatocytes. Here we describe the identification and initial characterization of dany, a gene required in spermatocytes for the large-scale change in gene expression. Similar to tMAC and tTAFs, the known major activators of spermatocyte-specific genes, dany has a recent evolutionary origin, but it functions independently. Like dan and danr, its primordial relatives with functions in somatic tissues, dany encodes a nuclear Psq domain protein. Dany associates preferentially with euchromatic genome regions. In dany mutant spermatocytes, activation of spermatocyte-specific genes and silencing of non-spermatocyte-specific genes are severely compromised and the chromatin no longer associates intimately with the nuclear envelope. Therefore, as suggested recently for Dan/Danr, we propose that Dany is essential for the coordination of change in cell type-specific expression programs and large-scale spatial chromatin reorganization. PMID:27436041

  4. A virtual control room with an embedded, interactive nuclear reactor simulator

    SciTech Connect

    Markidis, S.; Rizwan, U.

    2006-07-01

    The use of virtual nuclear control room can be an effective and powerful tool for training personnel working in the nuclear power plants. Operators could experience and simulate the functioning of the plant, even in critical situations, without being in a real power plant or running any risk. 3D models can be exported to Virtual Reality formats and then displayed in the Virtual Reality environment providing an immersive 3D experience. However, two major limitations of this approach are that 3D models exhibit static textures, and they are not fully interactive and therefore cannot be used effectively in training personnel. In this paper we first describe a possible solution for embedding the output of a computer application in a 3D virtual scene, coupling real-world applications and VR systems. The VR system reported here grabs the output of an application running on an X server; creates a texture with the output and then displays it on a screen or a wall in the virtual reality environment. We then propose a simple model for providing interaction between the user in the VR system and the running simulator. This approach is based on the use of internet-based application that can be commanded by a laptop or tablet-pc added to the virtual environment. (authors)

  5. REVIEW Of COMPUTERIZED PROCEDURE GUIDELINES FOR NUCLEAR POWER PLANT CONTROL ROOMS

    SciTech Connect

    David I Gertman; Katya Le Blanc; Ronald L Boring

    2011-09-01

    Computerized procedures (CPs) are recognized as an emerging alternative to paper-based procedures for supporting control room operators in nuclear power plants undergoing life extension and in the concept of operations for advanced reactor designs. CPs potentially reduce operator workload, yield increases in efficiency, and provide for greater resilience. Yet, CPs may also adversely impact human and plant performance if not designed and implemented properly. Therefore, it is important to ensure that existing guidance is sufficient to provide for proper implementation and monitoring of CPs. In this paper, human performance issues were identified based on a review of the behavioral science literature, research on computerized procedures in nuclear and other industries, and a review of industry experience with CPs. The review of human performance issues led to the identification of a number of technical gaps in available guidance sources. To address some of the gaps, we developed 13 supplemental guidelines to support design and safety. This paper presents these guidelines and the case for further research.

  6. Digital Full-Scope Simulation of a Conventional Nuclear Power Plant Control Room, Phase 2: Installation of a Reconfigurable Simulator to Support Nuclear Plant Sustainability

    SciTech Connect

    Ronald L. Boring; Vivek Agarwal; Kirk Fitzgerald; Jacques Hugo; Bruce Hallbert

    2013-03-01

    The U.S. Department of Energy’s Light Water Reactor Sustainability program has developed a control room simulator in support of control room modernization at nuclear power plants in the U.S. This report highlights the recent completion of this reconfigurable, full-scale, full-scope control room simulator buildout at the Idaho National Laboratory. The simulator is fully reconfigurable, meaning it supports multiple plant models developed by different simulator vendors. The simulator is full-scale, using glasstop virtual panels to display the analog control boards found at current plants. The present installation features 15 glasstop panels, uniquely achieving a complete control room representation. The simulator is also full-scope, meaning it uses the same plant models used for training simulators at actual plants. Unlike in the plant training simulators, the deployment on glasstop panels allows a high degree of customization of the panels, allowing the simulator to be used for research on the design of new digital control systems for control room modernization. This report includes separate sections discussing the glasstop panels, their layout to mimic control rooms at actual plants, technical details on creating a multi-plant and multi-vendor reconfigurable simulator, and current efforts to support control room modernization at U.S. utilities. The glasstop simulator provides an ideal testbed for prototyping and validating new control room concepts. Equally importantly, it is helping create a standardized and vetted human factors engineering process that can be used across the nuclear industry to ensure control room upgrades maintain and even improve current reliability and safety.

  7. Comparative mass spectrometry & nuclear magnetic resonance metabolomic approaches for nutraceuticals quality control analysis: a brief review.

    PubMed

    Farag, Mohamed A

    2014-01-01

    The number of botanical dietary supplements in the market has recently increased primarily due to increased health awareness. Standardization and quality control of the constituents of these plant extracts is an important topic, particularly when such ingredients are used long term as dietary supplements, or in cases where higher doses are marketed as drugs. The development of fast, comprehensive, and effective untargeted analytical methods for plant extracts is of high interest. Nuclear magnetic resonance spectroscopy and mass spectrometry are the most informative tools, each of which enables high-throughput and global analysis of hundreds of metabolites in a single step. Although only one of the two techniques is utilized in the majority of plant metabolomics applications, there is a growing interest in combining the data from both platforms to effectively unravel the complexity of plant samples. The application of combined MS and NMR in the quality control of nutraceuticals forms the major part of this review. Finally I will look at the future developments and perspectives of these two technologies for the quality control of herbal materials. PMID:24354527

  8. The Programmable Logic Controller and its application in nuclear reactor systems

    SciTech Connect

    Palomar, J.; Wyman, R.

    1993-09-01

    This document provides recommendations to guide reviewers in the application of Programmable Logic Controllers (PLCS) to the control, monitoring and protection of nuclear reactors. The first topics addressed are system-level design issues, specifically including safety. The document then discusses concerns about the PLC manufacturing organization and the protection system engineering organization. Supplementing this document are two appendices. Appendix A summarizes PLC characteristics. Specifically addressed are those characteristics that make the PLC more suitable for emergency shutdown systems than other electrical/electronic-based systems, as well as characteristics that improve reliability of a system. Also covered are PLC characteristics that may create an unsafe operating environment. Appendix B provides an overview of the use of programmable logic controllers in emergency shutdown systems. The intent is to familiarize the reader with the design, development, test, and maintenance phases of applying a PLC to an ESD system. Each phase is described in detail and information pertinent to the application of a PLC is pointed out.

  9. Aging Management Guideline for commercial nuclear power plants: Motor control centers; Final report

    SciTech Connect

    Toman, G.; Gazdzinski, R.; O`Hearn, E.

    1994-02-01

    This Aging Management Guideline (AMG) provides recommended methods for effective detection and mitigation of age-related degradation mechanisms in Boiling Water Reactor (BWR) and Pressurized Water Reactor (PWR) commercial nuclear power plant motor control centers important to license renewal. The intent of this AMG is to assist plant maintenance and operations personnel in maximizing the safe, useful life of these components. It also supports the documentation of effective aging management programs required under the License Renewal Rule 10 CFR Part 54. This AMG is presented in a manner that allows personnel responsible for performance analysis and maintenance to compare their plant-specific aging mechanisms (expected or already experienced) and aging management program activities to the more generic results and recommendations presented herein.

  10. Using micro saint to predict performance in a nuclear power plant control room

    SciTech Connect

    Lawless, M.T.; Laughery, K.R.; Persenky, J.J.

    1995-09-01

    The United States Nuclear Regulatory Commission (NRC) requires a technical basis for regulatory actions. In the area of human factors, one possible technical basis is human performance modeling technology including task network modeling. This study assessed the feasibility and validity of task network modeling to predict the performance of control room crews. Task network models were built that matched the experimental conditions of a study on computerized procedures that was conducted at North Carolina State University. The data from the {open_quotes}paper procedures{close_quotes} conditions were used to calibrate the task network models. Then, the models were manipulated to reflect expected changes when computerized procedures were used. These models` predictions were then compared to the experimental data from the {open_quotes}computerized conditions{close_quotes} of the North Carolina State University study. Analyses indicated that the models predicted some subsets of the data well, but not all. Implications for the use of task network modeling are discussed.

  11. Team interaction skills evaluation criteria for nuclear power plant control room operators

    SciTech Connect

    Montgomery, J.C.; Toquam, J.; Gaddy, C.

    1991-09-01

    Previous research has shown the value of good team interaction skills to group performance, yet little progress has been made on in terms of how such skills can be measured. In this study rating scales developed previously (Montgomery, et al., 1990) were extensively revised and cast into a Behaviorally Anchored Rating Scale (BARS) and a Behavioral Frequency format. Rating data were collected using 13 training instructors at the Diablo Canyon Nuclear Plant, who rated three videotapes of simulator scenario performance during a day-long training session and later evaluated control room crews during requalification training. High levels of interrater agreement on both rating scales were found. However, the factor structure of the ratings was generally inconsistent with that hypothesized. Analysis of training ratings using Cronbach`s components of accuracy (Cronbach, 1955) indicated that BARS ratings generally exhibited less error than did the Behavioral Frequency ratings. The results are discussed in terms of both field and research implications.

  12. The Ural Electrochemical Integrated Plant Sustainability Program of Nuclear Material Protection, Control and Accounting System Upgrades

    SciTech Connect

    Vakhonin, Alexander; Yuldashev, Rashid; Dabbs, Richard D.; Carroll, Michael F.; Garrett, Albert G.; Patrick, Scott W.; Ku, Eshter M.

    2009-09-30

    UEIP has been working on a comprehensive sustainability program that includes establishing a site sustainability working group, information gathering, planning, organizing, developing schedule and estimated costs, trhough joint UEIP-US DOE/NNSA National Laboratory sustainability contracts. Considerable efforts have been necessary in the sustainability planning, monitoring, and control of the scope of work using tools such as Microsoft Excel, Microsoft Project and SAP R/3. While information interchanges within the sustainability program provides adequate US assurances that US funds are well spent through its quarterly reporting methodology, proper information security and protection measures are taken throughout the process. Decommissioning of outdated equipment has also become part of determining sustainability requirements and processes. The site’s sustainability program has facilitated the development of a transition plan toward eventual full Russian funding of sustaining nuclear security upgrades.

  13. QUANTUM CONTROL OF LIGHT: From Slow Light and FAST CARS to Nuclear γ-ray Spectroscopy

    NASA Astrophysics Data System (ADS)

    Scully, Marlan

    2007-06-01

    In recent work we have demonstrated strong coherent backward wave oscillation using forward propagating fields only. This surprising result is achieved by applying laser fields to an ultra-dispersive medium with proper chosen detunings to excite a molecular vibrational coherence that corresponds to a backward propagating wave [PRL, 97, 113001 (2006)]. The physics then has much in common with propagation of ultra-slow light. Applications of coherent scattering and remote sensing to the detection of bio and chemical pathogens (e.g., anthrax) via Coherent Anti-Raman Scattering together with Femtosecond Adaptive Spectroscopic Techniques (FAST CARS [Opt. Comm., 244, 423 (2005)]) will be discussed. Furthermore, the interplay between quantum optics (Dicke super and sub-radiant states) and nuclear physics (forward scattering of γ radiation) provides interesting problems and insights into the quantum control of scattered light [PRL, 96, 010501 (2005)].

  14. New CAMAC based data acquisition and beam control system for Lund nuclear microprobe

    NASA Astrophysics Data System (ADS)

    Elfman, Mikael; Kristiansson, Per; Malmqvist, Klas; Pallon, Jan; Sjöland, Anders; Utui, Rogerio; Yang, Changyi

    1997-07-01

    A new CAMAC based data acquisition system has been installed at the Lund Nuclear Microprobe facility. This paper reports on the development and present status of the data acquisition system. The system is a true multiparameter CAMAC based system with fast Fera bus readout and in crate memory buffer. The user interface is based on Sparrow Kmax software for a Power Macintosh platform. The system read out and tag the event data with position on-line, which make fast on-line monitoring of spectra or element maps possible.Simultaneously, all data can be saved event by event for off-line analysis. The beam scanning part is software controlled through a timed D/A converter, this allows fast scanning of the beam. With a CCD-camera and video card the area to be analysed could be defined directly from the image, and the sample position can be moved. Any kind of irregular scan patterns could be defined.

  15. Control and applications of cooperating disparate robotic manipulators relevant to nuclear waste management

    NASA Technical Reports Server (NTRS)

    Lew, Jae Young; Book, Wayne J.

    1991-01-01

    Remote handling in nuclear waste management requires a robotic system with precise motion as well as a large workspace. The concept of a small arm mounted on the end of a large arm may satisfy such needs. However, the performance of such a serial configuration lacks payload capacity which is a crucial factor for handling a massive object. Also, this configuration induces more flexibility on the structure. To overcome these problems, the topology of bracing the tip of the small arm (not the large arm) and having an end effector in the middle of the chain is proposed in this paper. Also, control of these cooperating disparate manipulators is accomplished in computer simulations. Thus, this robotic system can have the accuracy of the small arm, and at the same time, it can have the payload capacity and large workspace of the large arm.

  16. Control of Nuclear Gloveboxes and Enclosures Using the No-Moving-Part Vortex Amplifier (VXA)

    SciTech Connect

    Crossley, M.J.

    2007-07-01

    This paper describes the components and operation of a no-moving-part control valve known as a Power Fluidic Vortex Amplifier (VXA). VXA's have been successfully used to control the operating environment of nuclear gloveboxes and other enclosures for over 30 years in the United Kingdom. AEA Technology ES. Inc. (AEAT) are now introducing the VXA into the US DOE Complex. Not only is the VXA capable of controlling the environment of small individual enclosures, such as gloveboxes, but it is also applicable to active facility-level ventilation systems that meet the requirements of the DNFSB's recommendation 2004-2 Revision 1. VXAs can be regarded as no moving part control dampers that regulate ventilation blower or header depressions down to a manageable level within an enclosure. VXAs are capable of reacting to perturbations such as containment breaches, hence avoiding the egress of contaminated materials into the working environment. For example, when connected to a 1.0 kPa (4'' wc) ventilation header, a working pressure of less than 0.25 kPa (1'' wc) can be maintained within the glovebox. However, if a loss of glove breach takes place, the VXA can instantaneously react to allow an ingress of air from the operator's environment sufficient to maintain a velocity of 1 ms{sup -1} at the breach. On replacement of the glove, the VXA will instantaneously return to the normal operating condition with no action required by the operator. The VXAs are not limited to the control of small enclosure ventilation systems. They are sufficiently scalable to be applied to large facility-level ventilation systems protecting suites of gloveboxes, personal access enclosures and entire facilities. The VXA and its uses are presented and discussed in this paper. (authors)

  17. Nuclear Data Library Effects on Fast to Thermal Flux Shapes Around PWR Control Rod Tips

    NASA Astrophysics Data System (ADS)

    Vasiliev, A.; Ferroukhi, H.; Zhu, T.; Pautz, A.

    2014-04-01

    The development of a high-fidelity computational scheme to estimate the accumulated fluence at the tips of PWR control rods (CR) has been initiated at the Paul Scherrer Institut (PSI). Both the fluence from high-energy (E>1 MeV) neutrons as well as for the thermal range (E<0.625 eV) are required as these affect the CR integrity through stresses/strains induced by coupled clad embrittlement / absorber swelling phenomena. The concept of the PSI scheme under development is to provide from validated core analysis models, the volumetric neutron source to a full core MCNPX model that is then used to compute the neutron fluxes. A particular aspect that needs scrutiny is the ability of the MCNPX-based calculation methodology to accurately predict the flux shapes along the control rod surfaces, especially for fully withdrawn CRs. In that case, the tip is located a short distance above the core/reflector interface and since this situation corresponds to a large part of reactor operation, the accumulated fluence will highly depend on the achieved calculation accuracy and precision in this non-fueled zone. The objective of the work presented in this paper is to quantify the influence of nuclear data on the calculated fluxes at the CR tips by (1) conducting a systematic comparison of modern neutron cross-section libraries, including JENDL-4.0, JEFF-3.1.1 and ENDF/B-VII.0, and (2) by quantifying the uncertainties in the neutron flux calculations with the help of available neutron cross-section variances/covariances data. For completeness, the magnitude of these nuclear data-based uncertainties is also assessed in relation to the influence from other typical sources of modeling uncertainties/biases.

  18. Follicular progesterone concentrations and messenger RNA expression of MATER and OCT-4 in immature bovine oocytes as predictors of developmental competence.

    PubMed

    Urrego, R; Herrera-Puerta, E; Chavarria, N A; Camargo, O; Wrenzycki, C; Rodriguez-Osorio, N

    2015-04-15

    The ability of bovine embryos to develop to the blastocyst stage and to implant and generate healthy offspring depends greatly on the competence of the oocyte. Oocyte competence is attributed to its close communication with the follicular environment and to its capacity to synthesize and store substantial amounts of messenger RNA. Higher developmental competence of bovine oocytes has been associated with both the expression of a cohort of developmental genes and the concentration of sex steroids in the follicular fluid. The aim of this study was to identify differences in the expression of FST in cumulus cells and OCT-4 and MATER in oocytes and the influence of the follicular progesterone and follicular estrogen concentration on the competence of bovine oocytes retrieved 30 minutes or 4 hours after slaughter. Cumulus-oocyte complexes (COCs) were left in postmortem ovaries for 30 minutes (group I) or 4 hours (group II) at 30 °C. Aspirated oocytes were then subjected to IVM, IVF, and IVC or were evaluated for MATER and OCT-4 messenger RNA abundance by quantitative real-time polymerase chain reaction. Total RNA was isolated from pools of 100 oocytes for each experimental replicate. Progesterone and estradiol concentration in follicular fluid was evaluated by immunoassay using an IMMULITE 2000 analyzer. Three repeats of in vitro embryo production were performed with a total of 455 (group I) and 470 (group II) COCs. There were no significant differences between the cleavage rates (72 hours postinsemination [hpi]) between both groups (63.5% vs. 69.1%). However, blastocyst (168 hpi) and hatching (216 hpi) rates were higher (P < 0.05) in group II compared with those of group I (21.3% vs. 30.7% and 27.6% vs. 51.5%, respectively). Group II oocytes exhibited the highest MATER and OCT-4 abundance (P < 0.05). Follicular estradiol concentration was not different between both the groups, whereas the progesterone concentration was lower (P ≤ 0.05) in group II follicles. These

  19. Reactor control system upgrade for the McClellan Nuclear Radiation Center Sacramento, CA.

    SciTech Connect

    Power, M. A.

    1999-03-10

    Argonne National Laboratory is currently developing a new reactor control system for the McClellan Nuclear Radiation Facility. This new control system not only provides the same functionality as the existing control system in terms of graphic displays of reactor process variables, data archival capability, and manual, automatic, pulse and square-wave modes of operation, but adds to the functionality of the previous control system by incorporating signal processing algorithms for the validation of sensors and automatic calibration and verification of control rod worth curves. With the inclusion of these automated features, the intent of this control system is not to replace the operator but to make the process of controlling the reactor easier and safer for the operator. For instance, an automatic control rod calibration method reduces the amount of time to calibrate control rods from days to minutes, increasing overall reactor utilization. The control rod calibration curve, determined using the automatic calibration system, can be validated anytime after the calibration, as long as the reactor power is between 50W and 500W. This is done by banking all of the rods simultaneously and comparing the tabulated rod worth curves with a reactivity computer estimate. As long as the deviation between the tabulated values and the reactivity estimate is within a prescribed error band, then the system is in calibration. In order to minimize the amount of information displayed, only the essential flux-related data are displayed in graphical format on the control screen. Information from the sensor validation methods is communicated to the operators via messages, which appear in a message window. The messages inform the operators that the actual process variables do not correlate within the allowed uncertainty in the reactor system. These warnings, however, cannot cause the reactor to shutdown automatically. The reactor operator has the ultimate responsibility of using this

  20. Nuclear weapons and nuclear war

    SciTech Connect

    Cassel, C.; McCally, M.; Abraham, H.

    1984-01-01

    This book examines the potential radiation hazards and environmental impacts of nuclear weapons. Topics considered include medical responsibility and thermonuclear war, the threat of nuclear war, nuclear weaponry, biological effects, radiation injury, decontamination, long-term effects, ecological effects, psychological aspects, the economic implications of nuclear weapons and war, ethics, civil defense, arms control, nuclear winter, and long-term biological consequences of nuclear war.

  1. Revision curricular a partir de un analisis comparativo de las discrepancias en los curriculos de una escuela de optometria en Puerto Rico con las competencias requeridas para las agencias de revalida y acreditacion 2004

    NASA Astrophysics Data System (ADS)

    Rivera Pacheco, Andres

    El proposito de esta investigacion, un estudio cualitativo de caso, fue comparar y contrastar el curriculo vigente de la Escuela de Optometria de la UIAPR con las competencias y estandares requeridos por las agencias de acreditacion y de revalida. Con este proposito, decidimos realizar una revision y un analisis de documentos: el prontuario de cada uno de los cursos de los curriculos implantados en el 1993 y en el 2001; las competencias y estandares establecidos por las agencias de revalida y de acreditacion; y las estadisticas en las que se analiza el porcentaje de estudiantes que aprueban cada una de las partes de los examenes de revalida entre el 1998 al 2003. Se realizaron entrevistas dirigidas para dar apoyo y complementar la revision y el analisis de estos documentos. Los participantes de las entrevistas fueron tres estudiantes de la clase de optometria del 2004 (ultima clase del curriculo del 1993); tres estudiantes de la clase de optometria del 2005 (primera clase graduanda del curriculo vigente) y tres profesores y/o directores de los Departamentos de Ciencias Basicas, Ciencias Clinicas y Cuidado al Paciente. Esta investigacion se enmarco en el modelo de evaluacion curricular de discrepancia de Malcolm Provus y en el modelo de desarrollo basado en competencias. Uno de los hallazgos mas importantes del estudio es que los cambios que se implantaron al curriculo del 2001 no han logrado que los estudiantes mejoren su ejecucion en los examenes de revalida. Por otro lado, se encontro que el curriculo vigente atiende completamente los estandares de la practica de Optometria, pero no las competencias. Esta informacion fue validada mediante el uso de una tabla de cotejo para el analisis de los cursos y de la informacion obtenida de las entrevistas. El estudio determina y concluye que existen discrepancias entre los prontuarios de los cursos del curriculo y las competencias requeridas por la agencia de revalida. Segundo, que el Departamento de Ciencias Basicas es el

  2. Research and development on the application of advanced control technologies to advanced nuclear reactor systems: A US national perspective

    SciTech Connect

    White, J.D.; Monson, L.R.; Carrol, D.G.; Dayal, Y.; Argonne National Lab., IL; General Electric Co., San Jose, CA )

    1989-01-01

    Control system designs for nuclear power plants are becoming more advanced through the use of digital technology and automation. This evolution is taking place because of: (1) the limitations in analog based control system performance and maintenance and availability and (2) the promise of significant improvement in plant operation and availability due to advances in digital and other control technologies. Digital retrofits of control systems in US nuclear plants are occurring now. Designs of control and protection systems for advanced LWRs are based on digital technology. The use of small inexpensive, fast, large-capacity computers in these designs is the first step of an evolutionary process described in this paper. Under the sponsorship of the US Department of Energy (DOE), Oak Ridge National Laboratory, Argonne National Laboratory, GE Nuclear Energy and several universities are performing research and development in the application of advances in control theory, software engineering, advanced computer architectures, artificial intelligence, and man-machine interface analysis to control system design. The target plant concept for the work described in this paper is the Power Reactor Inherently Safe Module reactor (PRISM), an advanced modular liquid metal reactor concept. This and other reactor designs which provide strong passive responses to operational upsets or accidents afford good opportunities to apply these advances in control technology. 18 refs., 5 figs.

  3. Control room modernization at Finnish nuclear power plants - Two projects compared

    SciTech Connect

    Laarni, J.; Norros, L.

    2006-07-01

    The modernization of automation systems and human-machine interfaces is a current issue at both of the two nuclear power plants (i.e., Fortum's Loviisa plant and TVO's Olkiluoto plant) in Finland. Since the plants have been launched in the 1970's or 1980's, technology is in part old-fashioned and needs to be renewed. At Olkiluoto upgrades of the turbine operator systems have already been conducted; at Loviisa the first phase of the modernization project has just started. Basically, there is a question of the complete digitalization of the information streams at the two plants, and transition from a conventional hard-wired or hybrid control room to a screen-based one. The new human-machine interfaces will comprise new technology, such as PC workstations, soft control, touch screens and large-screen overall displays. The modernization of human-system interfaces is carried out in a stepwise manner at both plants. At both plants the main driver has not been the need to renew the user interfaces of the control room, but the need to upgrade the automation systems. In part because of this, there is a lack of a systematic top-down approach in which different aspects of human factors (HF) engineering are considered in relationship to higher level goals. Our aim here is to give an overview description of the control room modernization projects at the two plants and provide a preliminary evaluation of their progress to date. The projects are also compared, for example, in terms of duration, scope and phasing, and who is responsible for the realization of the project. In addition, we also compare experiences from the Finnish projects to experiences from similar projects abroad. The main part of the data used in this study is based on designers' and project members' interviews. (authors)

  4. International training course on implementation of state systems of accounting for and control of nuclear materials: proceedings

    SciTech Connect

    Not Available

    1984-06-01

    This report incorporates all lectures and presentations at the International Training Course on Implementation of State Systems of Accounting for and Control of Nuclear Materials held October 17 through November 4, 1983, at Santa Fe and Los Alamos, New Mexico and Richland, Washington, USA. Authorized by the US Nuclear Non-Proliferation Act and sponsored by the US Department of Energy in cooperation with the International Atomic Energy Agency, the course was developed to provide practical training in the design, implementation, and operation of a State system of nuclear materials accountability and control that satisfies both national and international safeguards requirements. Major emphasis for the 1983 course was placed on safeguards methods used at bulk-handling facilities, particularly low-enriched uranium conversion and fuel fabrication plants. The course was conducted by the University of California's Los Alamos National Laboratory and Exxon Nuclear Company, Inc. Tours and demonstrations were arranged at the Los Alamos National Laboratory, Los Alamos, New Mexico, and the Exxon Nuclear fuel fabrication plant, the Battelle Pacific Northwest Laboratory, Westinghouse Fast Flux Test Facility Visitor Center, and Washington Public Power System nuclear reactor facilities in Richland, Washington. Individual presentations were indexed for inclusion in the Energy Data Base.

  5. Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin Sensitivity

    PubMed Central

    Qi, Zhengtang; Ding, Shuzhe

    2012-01-01

    The peroxisome proliferator-activated receptors (PPARs) and estrogen-related receptor (ERRα) are ligand-activated nuclear receptors that coordinately regulate gene expression. Recent evidence suggests that nuclear corepressors, NCoR, RIP140, and SMRT, repress nuclear receptors-mediated transcriptional activity on specific promoters, and thus regulate insulin sensitivity, adipogenesis, mitochondrial number, and activity in vivo. Moreover, the coactivator PGC-1α that increases mitochondrial biogenesis during exercise and calorie restriction directly regulates autophagy in skeletal muscle and mitophagy in the pathogenesis of Parkinson's disease. In this paper, we discuss the PGC-1α's novel role in mitochondrial quality control and the role of nuclear corepressors in regulating insulin sensitivity and interacting with PGC-1α. PMID:23304112

  6. The role of nuclear receptors in controlling the fine balance between proliferation and differentiation of neural stem cells.

    PubMed

    Stergiopoulos, Athanasios; Politis, Panagiotis K

    2013-06-01

    In the central nervous system (CNS) of vertebrates a large variety of cell types are specified from a pool of highly plastic neural stem/progenitor cells (NSCs) via a combined action of extrinsic morphogenetic cues and intrinsic transcriptional regulatory networks. Nuclear receptors and their ligands are key regulators of fate decisions in NSCs during development and adulthood, through their ability to control transcription of downstream genes. In the last few years considerable progress has been made towards the understanding of the actions of nuclear receptors in NSCs as well as elucidating the mechanistic basis for these actions. Here we summarize recent progress in the role of nuclear receptors in the biology of NSCs. These studies highlight the importance of this family of transcriptional regulators in CNS development and function in health and disease. Furthermore, they raise the intriguing possibility of using nuclear receptors as therapeutic targets for nervous system related diseases and traumas. PMID:23044345

  7. Nuclear receptor NR5A2 controls neural stem cell fate decisions during development

    PubMed Central

    Stergiopoulos, Athanasios; Politis, Panagiotis K.

    2016-01-01

    The enormous complexity of mammalian central nervous system (CNS) is generated by highly synchronized actions of diverse factors and signalling molecules in neural stem/progenitor cells (NSCs). However, the molecular mechanisms that integrate extrinsic and intrinsic signals to control proliferation versus differentiation decisions of NSCs are not well-understood. Here we identify nuclear receptor NR5A2 as a central node in these regulatory networks and key player in neural development. Overexpression and loss-of-function experiments in primary NSCs and mouse embryos suggest that NR5A2 synchronizes cell-cycle exit with induction of neurogenesis and inhibition of astrogliogenesis by direct regulatory effects on Ink4/Arf locus, Prox1, a downstream target of proneural genes, as well as Notch1 and JAK/STAT signalling pathways. Upstream of NR5a2, proneural genes, as well as Notch1 and JAK/STAT pathways control NR5a2 endogenous expression. Collectively, these observations render NR5A2 a critical regulator of neural development and target gene for NSC-based treatments of CNS-related diseases. PMID:27447294

  8. Criticality-Control Applications in the Nuclear Industry for Thermal Spray Amorphous Metal and Ceramic Coatings

    SciTech Connect

    Farmer, J; Choi, J

    2007-07-18

    Amorphous metal and ceramic thermal spray coatings have been developed that can be used to enhance the corrosion resistance of containers for the transportation, aging and disposal of spent nuclear fuel and high-level radioactive wastes. Iron-based amorphous metal formulations with chromium, molybdenum and tungsten have shown the corrosion resistance believed to be necessary for such applications. Rare earth additions enable very low critical cooling rates to be achieved. The boron content of these materials, and their stability at high neutron doses, enable them to serve as high efficiency neutron absorbers for criticality control. The high boron content of Fe{sub 49.7}Cr{sub 17.7}Mn{sub 1.9}Mo{sub 7.4}W{sub 1.6}B{sub 15.2}C{sub 3.8}Si{sub 2.4} (SAM2X5) makes it an effective neutron absorber, and suitable for criticality control applications. Average measured values of the neutron absorption cross section in transmission ({Sigma}{sub t}) for Type 316L stainless steel, Alloy C-22, borated stainless steel, a Ni-Cr-Mo-Gd alloy, and SAM2X5 have been determined to be approximately 1.1, 1.3, 2.3, 3.8 and 7.1 cm{sup -1}, respectively.

  9. International training course on implementation of state systems of accounting for and control of nuclear materials: proceedings

    SciTech Connect

    Not Available

    1986-06-01

    This report incorporates all lectures and presentations at the International Training Course on Implementation of State Systems of Accounting for and Control of Nuclear Materials held June 3 through June 21, 1985, at Santa Fe and Los Alamos, New Mexico, and San Clemente, California. Authorized by the US Nuclear Non-Proliferation Act and sponsored by the US Department of Energy in cooperation with the International Atomic Energy Agency, the Course was developed to provide practical training in the design, implementation, and operation of a state system of nuclear materials accountability and control that satisfies both national and international safeguards requirements. Major emphasis for the 1985 course was placed on safeguards methods used at item-control facilities, particularly nuclear power generating stations and test reactors. An introduction to safeguards methods used at bulk handling facilities, particularly low-enriched uranium conversion and fuel fabrication plants, was also included. The course was conducted by the University of California's Los Alamos National Laboratory and the Southern California Edison Company. Tours and demonstrations were arranged at the Los Alamos National Laboratory, Los Alamos, New Mexico, and the San Onofre Nuclear Generating Station, San Clemente, California.

  10. Nuclear material control and accounting and physical protection cooperation with the former Soviet Union

    SciTech Connect

    Sanders, K.; Cherry, R.; Kuzmycz, G. )

    1993-01-01

    The end of the Cold War precipitated an unprecedented, fast-paced effort by the United States and states of the former Soviet Union (FSU) to dismantle nuclear weapons. At the same time, instability in the FSU as nuclear stockpiles are drawn down has given rise to a proliferation threat potentially more serious than any nuclear crisis faced by the superpowers during their 40-yr standoff. With the FSU more susceptible than ever to proliferation and terrorist threats, it is probable that countries that intend to develop nuclear weapons will attempt or may already have attempted to obtain nuclear material not only from dismantled weapons but from civilian nuclear programs as well. Numerous reports have emerged in the international media during the past year alone on FSU nuclear material being lost, stolen, or recovered following theft attempts. Under the US initiative for nuclear weapons safety, security and dismantlement (SSD), and the President's Nonproliferation Initiative, the US Department of Energy (DOE) and the US Nuclear Regulatory Commission (NRC) are engaged in establishing bilateral technical assistance programs with FSU states in nuclear material safeguards. The overarching objective of US assistance is to help the FSU states improve their capabilities to effectively safeguard and protect nuclear material. The assistance will be carried out under bilateral agreements for cooperation and supported by funds authorized by Congress in the Soviet Nuclear Reduction Act of 1991 and successor legislation, such as the Freedom Support Act (1992).

  11. Nuclear Rocket Facility Decommissioning Project: Controlled Explosive Demolition of Neutron-Activated Shield Wall

    SciTech Connect

    Michael R. Kruzic

    2008-06-01

    Located in Area 25 of the Nevada Test Site (NTS), the Test Cell A (TCA) Facility (Figure 1) was used in the early to mid-1960s for testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program, to further space travel. Nuclear rocket testing resulted in the activation of materials around the reactors and the release of fission products and fuel particles. The TCA facility, known as Corrective Action Unit 115, was decontaminated and decommissioned (D&D) from December 2004 to July 2005 using the Streamlined Approach for Environmental Restoration (SAFER) process, under the Federal Facility Agreement and Consent Order. The SAFER process allows environmental remediation and facility closure activities (i.e., decommissioning) to occur simultaneously, provided technical decisions are made by an experienced decision maker within the site conceptual site model. Facility closure involved a seven-step decommissioning strategy. First, preliminary investigation activities were performed, including review of process knowledge documentation, targeted facility radiological and hazardous material surveys, concrete core drilling and analysis, shield wall radiological characterization, and discrete sampling, which proved to be very useful and cost-effective in subsequent decommissioning planning and execution and worker safety. Second, site setup and mobilization of equipment and personnel were completed. Third, early removal of hazardous materials, including asbestos, lead, cadmium, and oil, was performed ensuring worker safety during more invasive demolition activities. Process piping was to be verified void of contents. Electrical systems were de-energized and other systems were rendered free of residual energy. Fourth, areas of high radiological contamination were decontaminated using multiple methods. Contamination levels varied across the facility. Fixed beta/gamma contamination levels ranged up to 2 million disintegrations per minute (dpm)/100

  12. Development of uranium reference particles for nuclear safeguards and non-proliferation control

    NASA Astrophysics Data System (ADS)

    Kips, Ruth

    In the oversight of the nuclear Non-Proliferation Treaty and as part of the Additional Protocol of the International Atomic Energy Agency, environmental sampling has become an important tool for the detection of non-declared nuclear activities. One extensively developed technique in environmental sampling (ES) makes use of pieces of cotton cloth called swipes to wipe surfaces in and around a nuclear facility. The dust collected on these swipes typically contains micrometer-sized uranium particles with an isotopic composition characteristic for the processes at the inspected facility. Since its implementation in the 1990s, ES has proven to be a very effective tool in the detection of clandestine activities owing to a number of highly sensitive and selective techniques, including secondary ion mass spectrometry and thermal ionisation mass spectrometry. However, considering the potential consequences of the analyses, these measurements need to be subjected to a rigorous quality management system. In a continuous effort to improve the accuracy and detection efficiency of the uranium isotope ratio measurements, uranium particle reference materials are being developed by different research groups. It was concluded however, that the existing methods for the production of particulate reference materials generally do not reproduce the particles recovered from swipe samples. For this reason, we developed the aerosol deposition chamber at the Institute for Reference Materials and Measurements for the production of reference uranium particles that are representative of the particles collected at enrichment facilities. This method is based on the controlled hydrolysis of milligram amounts of uranium hexafluoride with a certified uranium isotopic composition. After optimization of the experimental set-up, the particles produced by the aerosol deposition chamber were characterized by scanning electron microscopy, transmission electron microscopy, micro-Raman spectroscopy and

  13. A Pilot Study Investigating the Effects of Advanced Nuclear Power Plant Control Room Technologies: Methods and Qualitative Results

    SciTech Connect

    BLanc, Katya Le; Powers, David; Joe, Jeffrey; Spielman, Zachary; Rice, Brandon; Fitzgerald, Kirk

    2015-08-01

    Control room modernization is an important part of life extension for the existing light water reactor fleet. None of the 99 currently operating commercial nuclear power plants in the U.S. has completed a full-scale control room modernization to date. Nuclear power plant main control rooms for the existing commercial reactor fleet remain significantly analog, with only limited digital modernizations. Upgrades in the U.S. do not achieve the full potential of newer technologies that might otherwise enhance plant and operator performance. The goal of the control room upgrade benefits research is to identify previously overlooked benefits of modernization, identify candidate technologies that may facilitate such benefits, and demonstrate these technologies through human factors research. This report describes a pilot study to test upgrades to the Human Systems Simulation Laboratory at INL.

  14. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE...

  15. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE...

  16. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE...

  17. 10 CFR 1044.09 - What do you do if you plan to disclose classified or unclassified controlled nuclear information...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false What do you do if you plan to disclose classified or unclassified controlled nuclear information orally rather than by providing copies of documents? 1044.09 Section 1044.09 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SECURITY REQUIREMENTS FOR PROTECTED DISCLOSURES UNDER SECTION 3164 OF THE...

  18. The modular nuclear absorber of the ATLAS hadron calorimeter (The experience controlled assembly of the surface and in the pit).

    SciTech Connect

    Proudfoot, J.; Batusov, V.; Budagov, J.; Leitener, R.; Lyablin, M.; Miralles, L.; Nessi, M.; Russakovich, N.; Sissakian, A.; Topilin, N.; Khubua, J.; Henriques, A.

    2009-01-01

    The Hadron Calorimeter of the ATLAS spectrometric complex is a principal part of the whole setup. This paper describes the developed concept and methods for the controlled construction of a steel nuclear calorimeter absorber which provides calorimeter assembly on the surface and in the underground experimental hall meeting the required design tolerances.

  19. The extra nuclear control of mitosis & cell function. A theory of cellular organisation.

    PubMed

    Holt, J A

    1980-02-01

    There is evidence to suggest that the extra nuclear cell constituents are the part of the cell which contains all the biochemical mechanisms responsible for implementing all cell functions. These functions include control of cell division, growth, response to injury, replacement of effete cells, maintenance of anatomical and spatial cellular relations and specific cellular function and structure. The energy to perform these functions is derived from the aerobic metabolism of glucose. The energy required for nuclear division appears to be wholly or partly derived from the anaerobic metabolism of glucose. Ethyl alcohol interferes with the aerobic metabolic pathways and thus disrupts or diminishes all aerobically activated cell functions. The speed of all activities motivated by aerobic glycolysis can be increased by appropriate electrical stimulations delivered from any of a range of electromagnetic radiation frequencies tested. In addition to the stimulant effect on aerobic metabolic processes, 434 MHz can stimulate the anaerobic glucose metabolism of cancer with consequent stimulation of cancer growth rate. 434 MHz appears to deliver energy to the anaerobic cancer metabolism by causing a resonance phenomenon amongst one or more of the substrates which comprise the first few stages of glycolysis. This phenomenon permits the selective delivery of electromagnetic radiation energy to cancer cells which, if sufficiently intense, causes injury to cancer cells without harm to the normal cells except when the latter are in the phase of anaerobic metabolism which occurs at some stage of the mitotic cycle. Streptokinase, ethanol and glucose analogues increase the lethal effects on cancers undergoing therapy with 434 MHz radiation and observations of such responses suggest a theoretical basis to explain the rare spontaneous remissions of human cancer. Cancer appears to protect its glucose supplies by elevating the blood glucose levels above normal and by some mechanism which

  20. Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster

    PubMed Central

    2012-01-01

    Background Mitochondria are organelles found in nearly all eukaryotic cells that play a crucial role in cellular survival and function. Mitochondrial function is under the control of nuclear and mitochondrial genomes. While the latter has been the focus of most genetic research, we remain largely ignorant about the nuclear-encoded genomic control of inter-individual variability in mitochondrial function. Here, we used Drosophila melanogaster as our model organism to address this question. Results We quantified mitochondrial state 3 and state 4 respiration rates and P:O ratio in mitochondria isolated from the thoraces of 40 sequenced inbred lines of the Drosophila Genetic Reference Panel. We found significant within-population genetic variability for all mitochondrial traits. Hence, we performed genome-wide association mapping and identified 141 single nucleotide polymorphisms (SNPs) associated with differences in mitochondrial respiration and efficiency (P ≤1 × 10-5). Gene-centered regression models showed that 2–3 SNPs can explain 31, 13, and 18% of the phenotypic variation in state 3, state 4, and P:O ratio, respectively. Most of the genes tagged by the SNPs are involved in organ development, second messenger-mediated signaling pathways, and cytoskeleton remodeling. One of these genes, sallimus (sls), encodes a component of the muscle sarcomere. We confirmed the direct effect of sls on mitochondrial respiration using two viable mutants and their coisogenic wild-type strain. Furthermore, correlation network analysis revealed that sls functions as a transcriptional hub in a co-regulated module associated with mitochondrial respiration and is connected to CG7834, which is predicted to encode a protein with mitochondrial electron transfer flavoprotein activity. This latter finding was also verified in the sls mutants. Conclusions Our results provide novel insights into the genetic factors regulating natural variation in mitochondrial function in D

  1. Nuclear criticality safety controls for uranium deposits during D and D at the Oak Ridge Gaseous Diffusion Plant

    SciTech Connect

    Haire, M.J.; Jordan, W.C.; Jollay, L.J. III; Dahl, T.L.

    1997-02-01

    The US Department of Energy (DOE) Deputy Assistant Secretary of Energy for Environmental Management has issued a challenge to complete DOE environmental cleanup within a decade. The response for Oak Ridge facilities is in accordance with the DOE ten-year plan which calls for completion of > 95% of environmental management work by the year 2006. This will result in a 99% risk reduction and in a significant savings in base line costs in waste management (legacy waste); remedial action (groundwater, soil, etc.); and decontamination and decommissioning (D and D). It is assumed that there will be long-term institutional control of cascade equipment, i.e., there will be no walk away from sites, and that there will be firm radioactivity release limits by 1999 for recycle metals. An integral part of these plants is the removal of uranium deposits which pose nuclear criticality safety concerns in the shut down of the Oak Ridge Gaseous Diffusion Plant. DOE has initiated the Nuclear Criticality Stabilization Program to improve nuclear criticality safety by removing the larger uranium deposits from unfavorable geometry equipment. Nondestructive assay (NDA) measurements have identified the location of these deposits. The objective of the K-25 Site Nuclear Criticality Stabilization Program is to remove and place uranium deposits into safe geometry storage containers to meet the double contingency principle. Each step of the removal process results in safer conditions where multiple controls are present. Upon completion of the Program, nuclear criticality risks will be greatly reduced.

  2. Components of the Arabidopsis nuclear pore complex play multiple diverse roles in control of plant growth

    PubMed Central

    Parry, Geraint

    2014-01-01

    The nuclear pore complex (NPC) is a multisubunit protein conglomerate that facilitates movement of RNA and protein between the nucleus and cytoplasm. Relatively little is known regarding the influence of the Arabidopsis NPC on growth and development. Seedling development, flowering time, nuclear morphology, mRNA accumulation, and gene expression changes in Arabidopsis nucleoporin mutants were investigated. Nuclear export of mRNA is differentially affected in plants with defects in nucleoporins that lie in different NPC subcomplexes. This study reveals differences in the manner by which nucleoporins alter molecular and plant growth phenotypes, suggesting that nuclear pore subcomplexes play distinct roles in nuclear transport and reveal a possible feedback relationship between the expression of genes involved in nuclear transport. PMID:25165147

  3. The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.

    PubMed

    Deuschle, Ulrich; Birkel, Manfred; Hambruch, Eva; Hornberger, Martin; Kinzel, Olaf; Perović-Ottstadt, Sanja; Schulz, Andreas; Hahn, Ulrike; Burnet, Michael; Kremoser, Claus

    2015-06-01

    The nuclear bile acid receptor Farnesoid X receptor (FXR) is strongly expressed in liver and intestine, controls bile acid and lipid homeostasis and exerts tumor-protective functions in liver and intestine. Histidine-rich glycoprotein (HRG) is an abundant plasma protein produced by the liver with the proposed function as a pattern recognition molecule involved in the clearance of immune complexes, necrotic cells and pathogens, the modulation of angiogenesis, the normalization of deranged endothelial vessel structure in tumors and tumor suppression. FXR recognition sequences were identified within a human HRG promoter fragment that mediated FXR/FXR-agonist dependent reporter gene activity in vitro. We show that HRG is a novel transcriptional target gene of FXR in human hepatoma cells, human upcyte® primary hepatocytes and 3D human liver microtissues in vitro and in mouse liver in vivo. Prolonged administration of the potent nonsteroidal FXR agonist PX20606 increases HRG levels in mouse plasma. Finally, daily oral administration of this FXR agonist for seven days resulted in a significant increase of HRG levels in the plasma of healthy human male volunteers during a clinical Phase I safety study. HRG might serve as a surrogate marker indicative of liver-specific FXR activation in future human clinical studies. Furthermore, potent FXR agonists might be beneficial in serious health conditions where HRG is reduced, for example, in hepatocellular carcinoma but also other solid cancers, liver failure, sepsis and pre-eclampsia. PMID:25363753

  4. DOE/DHS INDUSTRIAL CONTROL SYSTEM CYBER SECURITY PROGRAMS: A MODEL FOR USE IN NUCLEAR FACILITY SAFEGUARDS AND SECURITY

    SciTech Connect

    Robert S. Anderson; Mark Schanfein; Trond Bjornard; Paul Moskowitz

    2011-07-01

    Many critical infrastructure sectors have been investigating cyber security issues for several years especially with the help of two primary government programs. The U.S. Department of Energy (DOE) National SCADA Test Bed and the U.S. Department of Homeland Security (DHS) Control Systems Security Program have both implemented activities aimed at securing the industrial control systems that operate the North American electric grid along with several other critical infrastructure sectors (ICS). These programs have spent the last seven years working with industry including asset owners, educational institutions, standards and regulating bodies, and control system vendors. The programs common mission is to provide outreach, identification of cyber vulnerabilities to ICS and mitigation strategies to enhance security postures. The success of these programs indicates that a similar approach can be successfully translated into other sectors including nuclear operations, safeguards, and security. The industry regulating bodies have included cyber security requirements and in some cases, have incorporated sets of standards with penalties for non-compliance such as the North American Electric Reliability Corporation Critical Infrastructure Protection standards. These DOE and DHS programs that address security improvements by both suppliers and end users provide an excellent model for nuclear facility personnel concerned with safeguards and security cyber vulnerabilities and countermeasures. It is not a stretch to imagine complete surreptitious collapse of protection against the removal of nuclear material or even initiation of a criticality event as witnessed at Three Mile Island or Chernobyl in a nuclear ICS inadequately protected against the cyber threat.

  5. Heat Transfer Salts for Nuclear Reactor Systems - Chemistry Control, Corrosion Mitigation, and Modeling

    SciTech Connect

    Anderson, Mark; Sridharan, Kumar; Morgan, Dane; Peterson, Per; Calderoni, Pattrick; Scheele, Randall; Casekka, Andrew; McNamara, Bruce

    2015-01-22

    The concept of a molten salt reactor has existed for nearly sixty years. Previously all work was done during a large collaborative effort at Oak Ridge National Laboratory, culminating in a research reactor which operated for 15,000 hours without major error. This technical success has garnished interest in modern, high temperature, reactor schemes. Research using molten fluoride salts for nuclear applications requires a steady supply of high grade molten salts. There is no bulk supplier of research grade fluoride salts in the world, so a facility which could provide all the salt needed for testing at the University of Wisconsin had to be produced. Two salt purification devices were made for this purpose, a large scale purifier, and a small scale purifier, each designed to clean the salts from impurities and reduce their corrosion potential. As of now, the small scale has performed with flibe salt, hydrogen, and hydrogen fluoride, yielding clean salt. This salt is currently being used in corrosion testing facilities at the Massachusetts Institute of Technology and the University of Wisconsin. Working with the beryllium based salts requires extensive safety measures and health monitoring to prevent the development of acute or chronic beryllium disease, two pulmonary diseases created by an allergic reaction to beryllium in the lungs. Extensive health monitoring, engineering controls, and environment monitoring had to be set up with the University of Wisconsin department of Environment, Health and Safety. The hydrogen fluoride required for purification was also an extreme health hazard requiring thoughtful planning and execution. These dangers have made research a slow and tedious process. Simple processes, such as chemical handling and clean-up, can take large amounts of ingenuity and time. Other work has complemented the experimental research at Wisconsin to advance high temperature reactor goals. Modeling work has been performed in house to re

  6. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  7. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  8. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  9. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  10. 41 CFR 101-42.1102-4 - Nuclear Regulatory Commission-controlled materials.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... regulations of the NRC (see 10 CFR parts 30 through 35, 40, and 70). (c) Information and inquiries. All... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Nuclear Regulatory...-Special Types of Hazardous Materials and Certain Categories of Property § 101-42.1102-4 Nuclear...

  11. Initial Position, Personal Control, and Attributional Augmentation of Persuasive Communication on Nuclear Disarmament.

    ERIC Educational Resources Information Center

    Fleming, John H.; Shaver, Kelly G.

    The effectiveness of two alternative attitude change strategies--a traditional persuasive strategy and a combined attributional/persuasive strategy--in altering attitudes toward nuclear disarmament were compared. Seventeen male and 39 female undergraduate students at a small university participated. A nuclear disarmament attitude pretest was…

  12. The Fun30 Chromatin Remodeler Fft3 Controls Nuclear Organization and Chromatin Structure of Insulators and Subtelomeres in Fission Yeast

    PubMed Central

    Khorosjutina, Olga; Persson, Jenna; Smialowska, Agata; Javerzat, Jean-Paul; Ekwall, Karl

    2015-01-01

    In eukaryotic cells, local chromatin structure and chromatin organization in the nucleus both influence transcriptional regulation. At the local level, the Fun30 chromatin remodeler Fft3 is essential for maintaining proper chromatin structure at centromeres and subtelomeres in fission yeast. Using genome-wide mapping and live cell imaging, we show that this role is linked to controlling nuclear organization of its targets. In fft3∆ cells, subtelomeres lose their association with the LEM domain protein Man1 at the nuclear periphery and move to the interior of the nucleus. Furthermore, genes in these domains are upregulated and active chromatin marks increase. Fft3 is also enriched at retrotransposon-derived long terminal repeat (LTR) elements and at tRNA genes. In cells lacking Fft3, these sites lose their peripheral positioning and show reduced nucleosome occupancy. We propose that Fft3 has a global role in mediating association between specific chromatin domains and the nuclear envelope. PMID:25798942

  13. Nuclear magnetic resonance linewidth and spin diffusion in {sup 29}Si isotopically controlled silicon

    SciTech Connect

    Hayashi, Hiroshi; Itoh, Kohei M.; Vlasenko, Leonid S.

    2008-10-15

    A nuclear magnetic resonance (NMR) study was performed with n-type silicon single crystals containing {sup 29}Si isotope abundance f ranges from 1.2% to 99.2%. The nuclear spin diffusion coefficient D has been determined from the linewidth of significantly enhanced {sup 29}Si NMR signals utilizing a developed dynamic nuclear polarization (DNP) method. The {sup 29}Si NMR linewidth depends linearly on f, at least when f<10%, and approaches {proportional_to}f{sup 1/2} dependence when f>50%. The estimated {sup 29}Si nuclear spin diffusion time T{sub sd} between phosphorus atoms used for DNP is more than ten times shorter than the nuclear polarization time T{sub 1}{sup p} of {sup 29}Si nuclei around phosphorus. Therefore, the regime of 'rapid spin diffusion' is realized in the DNP experiments.

  14. MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress

    SciTech Connect

    Preta, Giulio; Klark, Rainier de; Chakraborti, Shankhamala; Glas, Rickard

    2010-08-27

    Research highlights: {yields} Nuclear translocation of TPPII occurs in response to different DNA damage inducers. {yields} Nuclear accumulation of TPPII is linked to ROS and anti-oxidant enzyme levels. {yields} MAPKs control nuclear accumulation of TPPII. {yields} Inhibited nuclear accumulation of TPPII decreases DNA damage-induced {gamma}-H2AX expression. -- Abstract: Reactive oxygen species (ROS) are a continuous hazard in eukaroytic cells by their ability to cause damage to biomolecules, in particular to DNA. Previous data indicated that the cytosolic serine peptidase tripeptidyl-peptidase II (TPPII) translocates into the nucleus of most tumor cell lines in response to {gamma}-irradiation and ROS production; an event that promoted p53 expression as well as caspase-activation. We here observed that nuclear translocation of TPPII was dependent on signaling by MAP kinases, including p38MAPK. Further, this was caused by several types of DNA-damaging drugs, a DNA cross-linker (cisplatinum), an inhibitor of topoisomerase II (etoposide), and to some extent also by nucleoside-analogues (5-fluorouracil, hydroxyurea). In the minority of tumor cell lines where TPPII was not translocated into the nucleus in response to DNA damage we observed reduced intracellular ROS levels, and the expression levels of redox defense systems were increased. Further, treatment with the ROS-inducer {gamma}-hexa-chloro-cyclohexane ({gamma}-HCH, lindane), an inhibitor of GAP junctions, restored nuclear translocation of TPPII in these cell lines upon {gamma}-irradiation. Moreover, blocking nuclear translocation of TPPII in etoposide-treated cells, by using a peptide-derived inhibitor (Z-Gly-Leu-Ala-OH), attenuated expression of {gamma}-H2AX in {gamma}-irradiated melanoma cells. Our results indicated a role for TPPII in MAPK-dependent DNA damage signaling.

  15. Minatom of Russia Situation and Crisis Center and the Automated Federal Information System for Nuclear Material Control and Accounting

    SciTech Connect

    Berchik,V P; Kasumova,L A; Babcock,R A; Heinberg,C L; Tynan,D M

    2001-06-25

    Under the Situation and Crisis Center (SCC) management, the Information Analytical Center (IAC) of the Ministry of Atomic Energy (Minatom) of Russia was created to oversee the operation of the Federal Nuclear Material Control and Accounting Information System (FIS). During 2000, the FIS achieved an important milestone in its development: the basic functions of the information system were implemented. This includes placing into operation the collecting and processing of nuclear material control and accounting (MC&A) information from the enterprises reporting to the FIS. The FIS began working with 14 Russian enterprises to develop and implement full-function reporting (i.e., reporting inventory and inventory changes including closeout and reconciliation between the FIS and enterprises). In 2001, the system will expand to include enterprise-level inventory information for all enterprises using nuclear materials in Russia. For this reason, at the end of 2000 through the beginning of 2001, five separate training sessions were held for over 100 enterprise personnel responsible for preparation and transfer of the reports to the FIS. Through the assistance of the Nuclear Material Protection, Control and Accounting (MPC&A) program, information systems for the accounting of nuclear materials are being installed at Russia enterprises. In creating the program for modernization of the Russian Federation State System of Accounting and Control (SSAC) of nuclear material, the SCC conducted a survey of the enterprises to determine the readiness of their internal MC&A systems for reporting to the FIS. Based on the information from the survey and the results of the projects on creation of local information systems at Russian enterprises, the analysis of information and the technical aspects of MC&A systems identified deficiencies that were analyzed and recommendations for eliminating these deficiencies were proposed. The concentration of analytical and administrative functions at the

  16. International workshop on new developments in occupational dose control and ALARA implementation at nuclear power plants and similar facilities: Proceedings

    SciTech Connect

    Baum, J.W.; Dionne, B.J.; Kahn, T.A. )

    1990-02-01

    This report contains summaries of papers and discussions presented at the International Workshop on New Developments in Occupational Dose Control and ALARA Implementation at Nuclear Power Plants and Similar Facilities held at Brookhaven National Laboratory, Upton, New York, September 18--21, 1989. The purpose of this workshop was to bring together scientists, engineers, regulators, and administrators who are involved with occupational dose control at nuclear facilities to exchange information on recent developments from their countries. The eleven countries represented included: Canada, Finland, France, Germany, Italy, Japan, Luxembourg, Sweden, Switzerland, United Kingdom, and the United States of America. The workshop was organized into seven sessions with 20-minute papers and four sessions with 5-minute discussions. The topics for the paper sessions included: Session 1, ALARA status, studies, and organization; Session 3, ALARA engineering in design and modifications; Session 5, system chemistry and water purification; Session 7, ALARA in operation I; Session 9, ALARA in operation II; Session 10, ALARA in operation III; and Session 11, the NEA Information System on Occupational Exposure. This workshop was sponsored jointly by the US Nuclear Regulatory Commission and the US Department of Energy, in cooperation with the Organization for Economic Cooperation and Development, Nuclear Energy Agency. Each individual paper has been catalogued separately.

  17. Interactions between mRNA Export Commitment, 3′-End Quality Control, and Nuclear Degradation

    PubMed Central

    Libri, Domenico; Dower, Ken; Boulay, Jocelyne; Thomsen, Rune; Rosbash, Michael; Jensen, Torben Heick

    2002-01-01

    Several aspects of eukaryotic mRNA processing are linked to transcription. In Saccharomyces cerevisiae, overexpression of the mRNA export factor Sub2p suppresses the growth defect of hpr1 null cells, yet the protein Hpr1p and the associated THO protein complex are implicated in transcriptional elongation. Indeed, we find that a pool of heat shock HSP104 transcripts are 3′-end truncated in THO complex mutant as well as sub2 mutant backgrounds. Surprisingly, however, this defect can be suppressed by deletion of the 3′-5′ exonuclease Rrp6p. This indicates that incomplete RNAs result from nuclear degradation rather than from a failure to efficiently elongate transcription. RNAs that are not degraded are retained at the transcription site in a Rrp6p-dependent manner. Interestingly, the addition of a RRP6 deletion to sub2 or to THO complex mutants shows a strong synthetic growth phenotype, suggesting that the failure to retain and/or degrade defective mRNAs is deleterious. mRNAs produced in the 3′-end processing mutants rna14-3 and rna15-2, as well as an RNA harboring a 3′ end generated by a self-cleaving hammerhead ribozyme, are also retained in Rrp6p-dependent transcription site foci. Taken together, our results show that several classes of defective RNPs are subject to a quality control step that impedes release from transcription site foci and suggest that suboptimal messenger ribonucleoprotein assembly leads to RNA degradation by Rrp6p. PMID:12417728

  18. Modified three-dimensional skull base model with artificial dura mater, cranial nerves, and venous sinuses for training in skull base surgery: technical note.

    PubMed

    Mori, Kentaro; Yamamoto, Takuji; Oyama, Kazutaka; Ueno, Hideaki; Nakao, Yasuaki; Honma, Keiichirou

    2008-12-01

    Experience with dissection of the cavernous sinus and the temporal bone is essential for training in skull base surgery, but the opportunities for cadaver dissection are very limited. A modification of a commercially available prototype three-dimensional (3D) skull base model, made by a selective laser sintering method and incorporating surface details and inner bony structures such as the inner ear structures and air cells, is proposed to include artificial dura mater, cranial nerves, venous sinuses, and the internal carotid artery for such surgical training. The transpetrosal approach and epidural cavernous sinus surgery (Dolenc's technique) were performed on this modified model using a high speed drill or ultrasonic bone curette under an operating microscope. The model could be dissected in almost the same way as a real cadaver. The modified 3D skull base model provides a good educational tool for training in skull base surgery. PMID:19106500

  19. The Fos expression in rat brain following electrical stimulation of dura mater surrounding the superior sagittal sinus changed with the pre-treatment of rizatriptan benzoate.

    PubMed

    Wang, Xiaolin; Yu, Shengyuan; Dong, Zhao; Jiang, Lei

    2011-01-01

    Fos expression in the brain was systematically investigated by means of immunohistochemical staining after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious rats. Fos-like immunoreactive neurons are distributed mainly in the upper cervical spinal cord, spinal trigeminal nucleus caudal part, raphe magnus nucleus, periaqueductal gray, ventromedial hypothalamic nucleus, and mediodorsal thalamus nucleus. With the pre-treatment of intraperitoneal injection of rizatriptan benzoate, the number of Fos-like immunoreactive neurons decreased in the spinal trigeminal nucleus caudal part and raphe magnus nucleus, increased in the periaqueductal gray, and remained unchanged in the ventromedial hypothalamic nucleus and mediodorsal thalamus nucleus. These results provide morphological evidence that the nuclei described above are involved in the development and maintenance of the trigeminovascular headache. PMID:20934408

  20. Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites.

    PubMed

    Yang, J; Song, H; Walsh, S; Bardes, E S; Kornbluth, S

    2001-02-01

    Entry into mitosis is regulated by the Cdc2 kinase complexed to B-type cyclins. We and others recently reported that cyclin B1/Cdc2 complexes, which appear to be constitutively cytoplasmic during interphase, actually shuttle continually into and out of the nucleus, with the rate of nuclear export exceeding the import rate (). At the time of entry into mitosis, the import rate is increased, whereas the export rate is decreased, leading to rapid nuclear accumulation of Cdc2/cyclin B1. Although it has recently been reported that phosphorylation of 4 serines within cyclin B1 promotes the rapid nuclear translocation of Cdc2/cyclin B1 at G(2)/M, the role that individual phosphorylation sites play in this process has not been examined (, ). We report here that phosphorylation of a single serine residue (Ser(113) of Xenopus cyclin B1) abrogates nuclear export of cyclin B1. This serine lies directly within the cyclin B1 nuclear export sequence and, when phosphorylated, prevents binding of the nuclear export factor, CRM1. In contrast, analysis of phosphorylation site mutants suggests that coordinate phosphorylation of all 4 serines (94, 96, 101, and 113) is required for the accelerated nuclear import of cyclin B1/Cdc2 characteristic of G(2)/M. Additionally, binding of cyclin B1 to importin-beta, the factor known to be responsible for the slow interphase nuclear entry of cyclin B1, appears to be unaffected by the phosphorylation state of cyclin B. These data suggest that a distinct import factor must be recruited to enhance nuclear entry of Cdc2/cyclin B1 at the G(2)/M transition. PMID:11060306

  1. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1

    PubMed Central

    Corum, Daniel G.; Tsichlis, Philip N.; Muise-Helmericks, Robin C.

    2014-01-01

    Our previous work has shown that Akt3 is required for mitochondrial biogenesis in primary human endothelial cells (ECs) and in Akt3-null mice; Akt3 affects subcellular localization of peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α), the master regulator of mitochondrial biogenesis. The purpose of this study is to determine the mechanism by which Akt3 controls the subcellular distribution of PGC-1α and to explore the effect on mitochondrial biogenesis and turnover during angiogenesis. Here we use standard biochemical analyses and Akt3-knockdown strategies to show that Akt3 controls the stabilization of chromosome maintenance region-1 (CRM-1), the major nuclear export receptor. Site-directed mutagenesis and association analyses show that PGC-1α nuclear export is CRM-1 dependent. Akt3 knockdown and CRM-1 overexpression cause 3-fold reductions in PGC-1α target gene expression, compared to control levels. Akt3 inhibition causes autophagy, as measured by autophagosome formation, in a CRM-1-dependent, Akt1/mTOR-independent pathway. In vivo, Akt3-null and heterozygous mice show dose-dependent decreases in angiogenesis compared to wild-type littermates (∼5- and 2.5-fold decreases, respectively), as assessed by Matrigel plug assays. This correlates with an ∼1.5-fold decrease in mitochondrial Cox IV expression. Our studies suggest that Akt3 is a regulator of mitochondrial dynamics in the vasculature via regulation of CRM-1-dependent nuclear export.—Corum, D. G., Tsichlis, P. N., Muise-Helmericks, R. C. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. PMID:24081905

  2. Towards a mutually reinforcing future : opportunities to integrate nuclear weapons stewardship and arms control objectives.

    SciTech Connect

    Sanders, Lani Miyoshi; DeLand, Sharon Marie; Pregenzer, Arian Leigh

    2010-07-01

    2010 NPR and President Obama's 2009 Prague Speech highlighted two key objectives with an inherent underlying tension: (1) Moving towards a world free of nuclear weapons; and (2) Sustaining a safe, secure, and effective nuclear arsenal. Objective 1 depends, inter alia, upon reductions in stockpiles at home and abroad and maintaining stability. Objective 2 depends upon needed investments in modernization and life extension. Objectives being pursued predominantly in parallel by largely separate communities.

  3. Qualification issues associated with the use of advanced instrumentation and control systems hardware in nuclear power plants

    SciTech Connect

    Korsah, K.; Antonescu, C.

    1993-10-01

    The instrumentation and control (I&C) systems in advanced reactors will make extensive use of digital controls, microprocessors, multiplexing, and Tiber-optic transmission. Elements of these advances in I&C have been implemented on some current operating plants. However, the widespread use of the above technologies, as well as the use of artificial intelligence with minimum reliance on human operator control of reactors, highlights the need to develop standards for qualifying I&C used in the next generation of nuclear power plants. As a first step in this direction, the protection system I&C for present-day plants was compared to that proposed for advanced light water reactors (ALWRs). An evaluation template was developed by assembling a configuration of a safety channel instrument string for a generic ALWR, then comparing the impact of environmental stressors on that string to their effect on an equivalent instrument string from an existing light water reactor. The template was then used to address reliability issues for microprocessor-based protection systems. Standards (or lack thereof) for the qualification of microprocessor-based safety I&C systems were also identified. This approach addresses in part issues raised in Nuclear Regulatory Commission policy document SECY-91-292. which recognizes that advanced I&C systems for the nuclear industry are ``being developed without consensus standards, as the technology available for design is ahead of the technology that is well understood through experience and supported by application standards.``

  4. Underground nuclear power station using self-regulating heat-pipe controlled reactors

    DOEpatents

    Hampel, Viktor E.

    1989-01-01

    A nuclear reactor for generating electricity is disposed underground at the bottom of a vertical hole that can be drilled using conventional drilling technology. The primary coolant of the reactor core is the working fluid in a plurality of thermodynamically coupled heat pipes emplaced in the hole between the heat source at the bottom of the hole and heat exchange means near the surface of the earth. Additionally, the primary coolant (consisting of the working flud in the heat pipes in the reactor core) moderates neutrons and regulates their reactivity, thus keeping the power of the reactor substantially constant. At the end of its useful life, the reactor core may be abandoned in place. Isolation from the atmosphere in case of accident or for abandonment is provided by the operation of explosive closures and mechanical valves emplaced along the hole. This invention combines technology developed and tested for small, highly efficient, space-based nuclear electric power plants with the technology of fast-acting closure mechanisms developed and used for underground testing of nuclear weapons. This invention provides a nuclear power installation which is safe from the worst conceivable reactor accident, namely, the explosion of a nuclear weapon near the ground surface of a nuclear power reactor.

  5. An underground nuclear power station using self-regulating heat-pipe controlled reactors

    DOEpatents

    Hampel, V.E.

    1988-05-17

    A nuclear reactor for generating electricity is disposed underground at the bottom of a vertical hole that can be drilled using conventional drilling technology. The primary coolant of the reactor core is the working fluid in a plurality of thermodynamically coupled heat pipes emplaced in the hole between the heat source at the bottom of the hole and heat exchange means near the surface of the earth. Additionally, the primary coolant (consisting of the working fluid in the heat pipes in the reactor core) moderates neutrons and regulates their reactivity, thus keeping the power of the reactor substantially constant. At the end of its useful life, the reactor core may be abandoned in place. Isolation from the atmosphere in case of accident or for abandonment is provided by the operation of explosive closures and mechanical valves emplaced along the hole. This invention combines technology developed and tested for small, highly efficient, space-based nuclear electric power plants with the technology of fast- acting closure mechanisms developed and used for underground testing of nuclear weapons. This invention provides a nuclear power installation which is safe from the worst conceivable reactor accident, namely, the explosion of a nuclear weapon near the ground surface of a nuclear power reactor. 5 figs.

  6. Effects of backlash and dead band on temperature control of the primary loop of a conceptual nuclear Brayton space powerplant

    NASA Technical Reports Server (NTRS)

    Petrick, E. J.

    1973-01-01

    An analytical study was made of the stability of a closed-loop liquid-lithium temperature control of the primary loop of a conceptual nuclear Brayton space powerplant. The operating point was varied from 20 to 120 percent of design. A describing-function technique was used to evaluate the effects of temperature dead band and control coupling backlash. From the system investigation, it was predicted that a limit cycle will not exist with a temperature dead band, but a limit cycle will not exist when backlash is present. The results compare favorably with a digital computer simulation.

  7. Brain cancer and nonoccupational risk factors: a case-control study among workers at two nuclear facilities

    SciTech Connect

    Carpenter, A.V.; Flanders, W.D.; Frome, E.L.; Cole, P.; Fry, S.A.

    1987-09-01

    In a nested case-control study of nuclear workers, 82 brain cancer cases were compared with 328 matched controls to investigate the possible association with nonoccupational risk factors such as histories of epilepsy or head injury. We observed a moderately strong association between brain cancer occurrence and history of epilepsy (OR = 5.7, 95 per cent CI: 1.0, 32.1), but did not find a positive association with previous head injury (OR = 0.9, 95 per cent CI: 0.2, 4.2).

  8. Interest in information as a function of worry and perceived control in the aftermath of nuclear disaster.

    PubMed

    Prince-Embury, S; Rooney, J F

    1987-01-01

    A survey of residents in the vicinity of the Three Mile Island nuclear generating facility four years after the accident examined level of interest in cancer detection and treatment, radiation monitoring, and epidemiology of cancer as a function of degree of ongoing worry, perceived control and demographic variables. Interest in information was found to be related to worry for all three topics, indicating that residents who had higher degrees of worry were more interested in seeking information than avoiding it. Control expectancy was related to interest in information about epidemiological distribution of cancer. Implications for the dissemination of information in the aftermath of a disaster are discussed. PMID:20841181

  9. Controlled light field concentration through turbid biological membrane for phototherapy

    PubMed Central

    Wang, Fujuan; He, Hexiang; Zhuang, Huichang; Xie, Xiangsheng; Yang, Zhenchong; Cai, Zhigang; Gu, Huaiyu; Zhou, Jianying

    2015-01-01

    Laser propagation through a turbid rat dura mater membrane is shown to be controllable with a wavefront modulation technique. The scattered light field can be refocused into a target area behind the rat dura mater membrane with a 110 times intensity enhancement using a spatial light modulator. The efficient laser intensity concentration system is demonstrated to imitate the phototherapy for human brain tumors. The power density in the target area is enhanced more than 200 times compared with the input power density on the dura mater membrane, thus allowing continued irradiation concentration to the deep lesion without damage to the dura mater. Multibeam inputs along different directions, or at different positions, can be guided to focus to the same spot behind the membrane, hence providing a similar gamma knife function in optical spectral range. Moreover, both the polarization and the phase of the input field can be recovered in the target area, allowing coherent field superposition in comparison with the linear intensity superposition for the gamma knife. PMID:26114042

  10. Nuclear rights - nuclear wrongs

    SciTech Connect

    Paul, E.F.; Miller, F.D.; Paul, J.; Ahrens, J.

    1986-01-01

    This book contains 11 selections. The titles are: Three Ways to Kill Innocent Bystanders: Some Conundrums Concerning the Morality of War; The International Defense of Liberty; Two Concepts of Deterrence; Nuclear Deterrence and Arms Control; Ethical Issues for the 1980s; The Moral Status of Nuclear Deterrent Threats; Optimal Deterrence; Morality and Paradoxical Deterrence; Immoral Risks: A Deontological Critique of Nuclear Deterrence; No War Without Dictatorship, No Peace Without Democracy: Foreign Policy as Domestic Politics; Marxism-Leninism and its Strategic Implications for the United States; Tocqueveille War.

  11. Assessing controls on perched saturated zones beneath the Idaho Nuclear Technology and Engineering Center, Idaho

    USGS Publications Warehouse

    Mirus, Benjamin B.; Perkins, Kim S.; Nimmo, John R.

    2011-01-01

    Waste byproducts associated with operations at the Idaho Nuclear Technology and Engineering Center (INTEC) have the potential to contaminate the eastern Snake River Plain (ESRP) aquifer. Recharge to the ESRP aquifer is controlled largely by the alternating stratigraphy of fractured volcanic rocks and sedimentary interbeds within the overlying vadose zone and by the availability of water at the surface. Beneath the INTEC facilities, localized zones of saturation perched on the sedimentary interbeds are of particular concern because they may facilitate accelerated transport of contaminants. The sources and timing of natural and anthropogenic recharge to the perched zones are poorly understood. Simple approaches for quantitative characterization of this complex, variably saturated flow system are needed to assess potential scenarios for contaminant transport under alternative remediation strategies. During 2009-2011, the U.S. Geological Survey (USGS), in cooperation with the U.S. Department of Energy, employed data analysis and numerical simulations with a recently developed model of preferential flow to evaluate the sources and quantity of recharge to the perched zones. Piezometer, tensiometer, temperature, precipitation, and stream-discharge data were analyzed, with particular focus on the possibility of contributions to the perched zones from snowmelt and flow in the neighboring Big Lost River (BLR). Analysis of the timing and magnitude of subsurface dynamics indicate that streamflow provides local recharge to the shallow, intermediate, and deep perched saturated zones within 150 m of the BLR; at greater distances from the BLR the influence of streamflow on recharge is unclear. Perched water-level dynamics in most wells analyzed are consistent with findings from previous geochemical analyses, which suggest that a combination of annual snowmelt and anthropogenic sources (for example, leaky pipes and drainage ditches) contribute to recharge of shallow and

  12. Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci.

    PubMed

    Rother, Magdalena B; Palstra, Robert-Jan; Jhunjhunwala, Suchit; van Kester, Kevin A M; van IJcken, Wilfred F J; Hendriks, Rudi W; van Dongen, Jacques J M; Murre, Cornelis; van Zelm, Menno C

    2016-01-01

    Progenitor-B cells recombine their immunoglobulin (Ig) loci to create unique antigen receptors. Despite a common recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner. We studied pre-pro-B cells and Rag(-/-) progenitor-B cells to determine whether Ig locus contraction or nuclear positioning is decisive for stepwise rearrangements. We found that both Ig loci were contracted in pro-B and pre-B cells. Igh relocated from the nuclear lamina to central domains only at the pro-B cell stage, whereas, Igκ remained sequestered at the lamina, and only at the pre-B cell stage located to central nuclear domains. Finally, in vitro induced re-positioning of Ig alleles away from the nuclear periphery increased germline transcription of Ig loci in pre-pro-B cells. Thus, Ig locus contraction juxtaposes genomically distant elements to mediate efficient recombination, however, sequential positioning of Ig loci away from the nuclear periphery determines stage-specific accessibility of Ig loci. PMID:26384565

  13. Microtubule Initiation from the Nuclear Surface Controls Cortical Microtubule Growth Polarity and Orientation in Arabidopsis thaliana

    PubMed Central

    Ambrose, Chris; Wasteneys, Geoffrey O.

    2014-01-01

    The nuclear envelope in plant cells has long been known to be a microtubule organizing center (MTOC), but its influence on microtubule organization in the cell cortex has been unclear. Here we show that nuclear MTOC activity favors the formation of longitudinal cortical microtubule (CMT) arrays. We used green fluorescent protein (GFP)-tagged gamma tubulin-complex protein 2 (GCP2) to identify nuclear MTOC activity and GFP-tagged End-Binding Protein 1b (EB1b) to track microtubule growth directions. We found that microtubules initiate from nuclei and enter the cortex in two directions along the long axis of the cell, creating bipolar longitudinal CMT arrays. Such arrays were observed in all cell types showing nuclear MTOC activity, including root hairs, recently divided cells in root tips, and the leaf epidermis. In order to confirm the causal nature of nuclei in bipolar array formation, we displaced nuclei by centrifugation, which generated a corresponding shift in the bipolarity split point. We also found that bipolar CMT arrays were associated with bidirectional trafficking of vesicular components to cell ends. Together, these findings reveal a conserved function of plant nuclear MTOCs and centrosomes/spindle pole bodies in animals and fungi, wherein all structures serve to establish polarities in microtubule growth. PMID:25008974

  14. Controlling the atom. The beginnings of nuclear regulation 1946--1962

    SciTech Connect

    Mazuzan, G.T.; Walker, J.S.

    1997-08-01

    This book traces the early history of nuclear power regulation in the US. It focuses on the Atomic Energy Commission (AEC), the federal agency that until 1975 was primarily responsible for planning and carrying out programs to protect public health and safety from the hazards of the civilian use of nuclear energy. It also describes the role of other groups that figured significantly in the development of regulatory policies, including the congressional Joint Committee on Atomic Energy, federal agencies other than the AEC, state governments, the nuclear industry, and scientific organizations. And it considers changes in public perceptions of and attitudes toward atomic energy and the dangers of radiation exposure. The context in which regulatory programs evolved is a rich and complex mixture of political, legislative, legal, technological, scientific, and administrative history. The basic purpose of this book is to provide the Nuclear Regulatory Commission (NRC), which inherited responsibility for nuclear safety after Congress disbanded the AEC, and the general public with information on the historical antecedents and background of regulatory issues.

  15. US/Russian cooperative efforts in nuclear material protection, control, and accounting at the Siberian Chemical Combine

    SciTech Connect

    Goloskokov, I.; Yarygin, A.; Petrushev, V.; Morgado, R.E.

    1998-12-31

    The Siberian Chemical Combine (SKhK) is the largest multifunction nuclear production facility in the Russian nuclear complex. Until recently, it produced and processed special nuclear material for the Russian Defense Ministry. SKhK and its US partners in the Department of Energy (DOE) US/Russian Materials Protection, Control, and Accountability (MPC and A) Program are nearing completion of the initial MPC and A upgrades at the six SKhK plant sites that were begun three years ago. Comprehensive enhancements to the physical protection and access control systems are progressing on a site-wide basis while a comprehensive MC and A system is being implemented at the Radiochemical Plant site. SKhK now produces thermal and electrical power, enriches uranium for commercial reactor fuel, reprocesses irradiated fuel, converts high-enriched uranium metal into high-enriched oxide for blending into reactor-grade, low-enriched uranium, and manufactures civilian products. The authors review the progress to date and outline plans for continuing the work in 1999.

  16. Spectroscopic On-Line Monitoring for Process Control and Safeguarding of Radiochemical Streams in Nuclear Fuel Reprocessing Facilities

    SciTech Connect

    Bryan, Samuel A.; Levitskaia, Tatiana G.; Casella, Amanda J.; Peterson, James M.; Johnsen, Amanda M.; Lines, Amanda M.; Thomas, Elizabeth M.

    2011-03-01

    The current book chapter presents preliminary work toward the use of spectroscopic on-line monitoring for process control and safeguarding of radiochemical streams. Raman spectroscopy was demonstrated as a method for determining U(VI), nitrate, and nitric acid, while visible-near-infrared (vis-NIR) spectroscopy was demonstrated as a method for determining Pu(IV), Np(V), U(VI) and Nd(III). This method has been established using fuel reprocessing solution stimulants under dynamic flow conditions and on commercial spent nuclear fuel samples. Partial least squares (PLS) models for each analyte were prepared, and the fits of the data presented. A brief review of literature relevant to the use of vibrational spectroscopy and physicochemical measurements for process monitoring of nuclear fuel solutions is reported.

  17. Nuclear localization of platelet-activating factor receptor controls retinal neovascularization

    PubMed Central

    K Bhosle, Vikrant; Rivera, José Carlos; Zhou, Tianwei (Ellen); Omri, Samy; Sanchez, Melanie; Hamel, David; Zhu, Tang; Rouget, Raphael; Rabea, Areej Al; Hou, Xin; Lahaie, Isabelle; Ribeiro-da-Silva, Alfredo; Chemtob, Sylvain

    2016-01-01

    Platelet-activating factor (PAF) is a pleiotropic phospholipid with proinflammatory, procoagulant and angiogenic actions on the vasculature. We and others have reported the presence of PAF receptor (Ptafr) at intracellular sites such as the nucleus. However, mechanisms of localization and physiologic functions of intracellular Ptafr remain poorly understood. We hereby identify the importance of C-terminal motif of the receptor and uncover novel roles of Rab11a GTPase and importin-5 in nuclear translocation of Ptafr in primary human retinal microvascular endothelial cells. Nuclear localization of Ptafr is independent of exogenous PAF stimulation as well as intracellular PAF biosynthesis. Moreover, nuclear Ptafr is responsible for the upregulation of unique set of growth factors, including vascular endothelial growth factor, in vitro and ex vivo. We further corroborate the intracrine PAF signaling, resulting in angiogenesis in vivo, using Ptafr antagonists with distinct plasma membrane permeability. Collectively, our findings show that nuclear Ptafr translocates in an agonist-independent manner, and distinctive functions of Ptafr based on its cellular localization point to another dimension needed for pharmacologic selectivity of drugs. PMID:27462464

  18. Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability

    PubMed Central

    Su, Xiaofeng A.; Dion, Vincent; Gasser, Susan M.

    2015-01-01

    Secondary structure-forming DNA sequences such as CAG repeats interfere with replication and repair, provoking fork stalling, chromosome fragility, and recombination. In budding yeast, we found that expanded CAG repeats are more likely than unexpanded repeats to localize to the nuclear periphery. This positioning is transient, occurs in late S phase, requires replication, and is associated with decreased subnuclear mobility of the locus. In contrast to persistent double-stranded breaks, expanded CAG repeats at the nuclear envelope associate with pores but not with the inner nuclear membrane protein Mps3. Relocation requires Nup84 and the Slx5/8 SUMO-dependent ubiquitin ligase but not Rad51, Mec1, or Tel1. Importantly, the presence of the Nup84 pore subcomplex and Slx5/8 suppresses CAG repeat fragility and instability. Repeat instability in nup84, slx5, or slx8 mutant cells arises through aberrant homologous recombination and is distinct from instability arising from the loss of ligase 4-dependent end-joining. Genetic and physical analysis of Rad52 sumoylation and binding at the CAG tract suggests that Slx5/8 targets sumoylated Rad52 for degradation at the pore to facilitate recovery from acute replication stress by promoting replication fork restart. We thereby confirmed that the relocation of damage to nuclear pores plays an important role in a naturally occurring repair process. PMID:25940904

  19. VALIDATION OF NUCLEAR MATERIAL CONTROL AND ACCOUNTABILITY (MC&A) SYSTEM EFFECTIVENESS TOOL (MSET) AT IDAHO NATIONAL LABORATORY (INL)

    SciTech Connect

    Meppen, Bruce; Haga, Roger; Moedl, Kelley; Bean, Tom; Sanders, Jeff; Thom, Mary Alice

    2008-07-01

    A Nuclear Material Control and Accountability (MC&A) Functional Model has been developed to describe MC&A systems at facilities possessing Category I or II Special Nuclear Material (SNM). Emphasis is on achieving the objectives of 144 “Fundamental Elements” in key areas ranging from categorization of nuclear material to establishment of Material Balance Areas (MBAs), controlling access, performing quality measurements of inventories and transfers, timely reporting all activities, and detecting and investigating anomalies. An MC&A System Effectiveness Tool (MSET), including probabilistic risk assessment (PRA) technology for evaluating MC&A effectiveness and relative risk, has been developed to accompany the Functional Model. The functional model and MSET were introduced at the 48th annual International Nuclear Material Management (INMM) annual meeting in July, 20071,2. A survey/questionnaire is used to accumulate comprehensive data regarding the MC&A elements at a facility. Data is converted from the questionnaire to numerical values using the DELPHI method and exercises are conducted to evaluate the overall effectiveness of an MC&A system. In 2007 a peer review was conducted and a questionnaire was completed for a hypothetical facility and exercises were conducted. In the first quarter of 2008, a questionnaire was completed at Idaho National Laboratory (INL) and MSET exercises were conducted. The experience gained from conducting the MSET exercises at INL helped evaluate the completeness and consistency of the MC&A Functional Model, descriptions of fundamental elements of the MC&A Functional Model, relationship between the MC&A Functional Model and the MC&A PRA tool and usefulness of the MSET questionnaire data collection process.

  20. Human factors design, verification, and validation for two types of control room upgrades at a nuclear power plant

    SciTech Connect

    Boring, Laurids Ronald

    2014-10-01

    This paper describes the NUREG-0711 based human factors engineering (HFE) phases and associated elements required to support design, verification and validation (V&V), and implementation of a new plant process computer (PPC) and turbine control system (TCS) at a representative nuclear power plant. This paper reviews ways to take a human-system interface (HSI) specification and use it when migrating legacy PPC displays or designing displays with new functionality. These displays undergo iterative usability testing during the design phase and then undergo an integrated system validation (ISV) in a full scope control room training simulator. Following the successful demonstration of operator performance with the systems during the ISV, the new system is implemented at the plant, first in the training simulator and then in the main control room.

  1. Program for upgrading nuclear materials protection, control, and accounting at all facilities within the All-Russian Institute of Experimental Physics (VNIIEF)

    SciTech Connect

    Yuferev, V.; Zhikharev, S.; Yakimov, Y.

    1998-12-31

    As part of the Department of Energy-Russian program for strengthening nuclear material protection, control, and accounting (MPC and A), plans have now been formulated to install an integrated MPC and A system at all facilities containing large quantities of weapons-usable nuclear material within the All-Russian Institute of Experimental Physics (VNIIEF, Arzamas-16) complex. In addition to storage facilities, the complex houses a number of critical facilities used to conduct nuclear physics research and facilities for developing procedures for disassembly of nuclear weapons.

  2. Application of Neutron-Absorbing Structural-Amorphous Metal (SAM) Coatings for Spent Nuclear Fuel (SNF) Container to Enhance Criticality Safety Control

    SciTech Connect

    Choi, J

    2007-01-12

    This report describes the analysis and modeling approaches used in the evaluation for criticality-control applications of the neutron-absorbing structural-amorphous metal (SAM) coatings. The applications of boron-containing high-performance corrosion-resistant material (HPCRM)--amorphous metal as the neutron-absorbing coatings to the metallic support structure can enhance criticality safety controls for spent nuclear fuel in baskets inside storage containers, transportation casks, and disposal containers. The use of these advanced iron-based, corrosion-resistant materials to prevent nuclear criticality in transportation, aging, and disposal containers would be extremely beneficial to the nuclear waste management programs.

  3. FAULT DIAGNOSIS WITH MULTI-STATE ALARMS IN A NUCLEAR POWER CONTROL SIMULATOR

    SciTech Connect

    Austin Ragsdale; Roger Lew; Brian P. Dyre; Ronald L. Boring

    2012-10-01

    This research addresses how alarm systems can increase operator performance within nuclear power plant operations. The experiment examined the effect of two types of alarm systems (two-state and three-state alarms) on alarm compliance and diagnosis for two types of faults differing in complexity. We hypothesized three-state alarms would improve performance in alarm recognition and fault diagnoses over that of two-state alarms. We used sensitivity and criterion based on Signal Detection Theory to measure performance. We further hypothesized that operator trust would be highest when using three-state alarms. The findings from this research showed participants performed better and had more trust in three-state alarms compared to two-state alarms. Furthermore, these findings have significant theoretical implications and practical applications as they apply to improving the efficiency and effectiveness of nuclear power plant operations.

  4. Fault Diagnosis with Multi-State Alarms in a Nuclear Power Control Simulation

    SciTech Connect

    Stuart A. Ragsdale; Roger Lew; Ronald L. Boring

    2014-09-01

    This research addresses how alarm systems can increase operator performance within nuclear power plant operations. The experiment examined the effects of two types of alarm systems (two-state and three-state alarms) on alarm compliance and diagnosis for two types of faults differing in complexity. We hypothesized the use of three-state alarms would improve performance in alarm recognition and fault diagnoses over that of two-state alarms. Sensitivity and criterion based on the Signal Detection Theory were used to measure performance. We further hypothesized that operator trust would be highest when using three-state alarms. The findings from this research showed participants performed better and had more trust in three-state alarms compared to two-state alarms. Furthermore, these findings have significant theoretical implications and practical applications as they apply to improving the efficiency and effectiveness of nuclear power plant operations.

  5. Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions

    PubMed Central

    Schachtrup, Christian; Ryu, Jae Kyu; Mammadzada, Könül; Khan, Abdullah S.; Carlton, Peter M.; Perez, Alex; Christian, Frank; Le Moan, Natacha; Vagena, Eirini; Baeza-Raja, Bernat; Rafalski, Victoria; Chan, Justin P.; Nitschke, Roland; Houslay, Miles D.; Ellisman, Mark H.; Wyss-Coray, Tony; Palop, Jorge J.; Akassoglou, Katerina

    2016-01-01

    Astrocytes play critical roles in neuronal activity and inhibition of regeneration. Here we show that the cleaved p75 neurotrophin receptor (p75NTR) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of TGF-β signaling. The cleaved p75NTR interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75NTR controls astrocyte-neuronal communication in response to profibrotic factors. PMID:26120963

  6. Thermal control of high energy nuclear waste, space option. [mathematical models

    NASA Technical Reports Server (NTRS)

    Peoples, J. A.

    1979-01-01

    Problems related to the temperature and packaging of nuclear waste material for disposal in space are explored. An approach is suggested for solving both problems with emphasis on high energy density waste material. A passive cooling concept is presented which utilized conduction rods that penetrate the inner core. Data are presented to illustrate the effectiveness of the rods and the limit of their capability. A computerized thermal model is discussed and developed for the cooling concept.

  7. Team situation awareness in nuclear power plant process control: A literature review, task analysis and future research

    SciTech Connect

    Ma, R.; Kaber, D. B.; Jones, J. M.; Starkey, R. L.

    2006-07-01

    Operator achievement and maintenance of situation awareness (SA) in nuclear power plant (NPP) process control has emerged as an important concept in defining effective relationships between humans and automation in this complex system. A literature review on factors influencing SA revealed several variables to be important to team SA, including the overall task and team goals, individual tasks, team member roles, and the team members themselves. Team SA can also be adversely affected by a range of factors, including stress, mental over- or under-loading, system design (including human-machine interface design), complexity, human error in perception, and automation. Our research focused on the analysis of 'shared' SA and team SA among an assumed three-person, main-control-room team. Shared SA requirements represent the knowledge that is held in common by NPP operators, and team SA represents the collective, unique knowledge of all operators. The paper describes an approach to goal-directed task analysis (GDTA) applied to NPP main control room operations. In general, the GDTA method reveals critical operator decision and information requirements. It identifies operator SA requirements relevant to performing complex systems control. The GDTA can reveal requirements at various levels of cognitive processing, including perception, comprehension and projection, in NPP process control. Based on the literature review and GDTA approach, a number of potential research issues are proposed with an aim toward understanding and facilitating team SA in NPP process control. (authors)

  8. Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2

    PubMed Central

    Barrales, Ramón Ramos; Forn, Marta; Georgescu, Paula Raluca; Sarkadi, Zsuzsa; Braun, Sigurd

    2016-01-01

    Transcriptionally silent chromatin localizes to the nuclear periphery, which provides a special microenvironment for gene repression. A variety of nuclear membrane proteins interact with repressed chromatin, yet the functional role of these interactions remains poorly understood. Here, we show that, in Schizosaccharomyces pombe, the nuclear membrane protein Lem2 associates with chromatin and mediates silencing and heterochromatin localization. Unexpectedly, we found that these functions can be separated and assigned to different structural domains within Lem2, excluding a simple tethering mechanism. Chromatin association and tethering of centromeres to the periphery are mediated by the N-terminal LEM (LAP2–Emerin–MAN1) domain of Lem2, whereas telomere anchoring and heterochromatin silencing require exclusively its conserved C-terminal MSC (MAN1–Src1 C-terminal) domain. Particularly, silencing by Lem2 is epistatic with the Snf2/HDAC (histone deacetylase) repressor complex SHREC at telomeres, while its necessity can be bypassed by deleting Epe1, a JmjC protein with anti-silencing activity. Furthermore, we found that loss of Lem2 reduces heterochromatin association of SHREC, which is accompanied by increased binding of Epe1. This reveals a critical function of Lem2 in coordinating these antagonistic factors at heterochromatin. The distinct silencing and localization functions mediated by Lem2 suggest that these conserved LEM-containing proteins go beyond simple tethering to play active roles in perinuclear silencing. PMID:26744419

  9. ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

    PubMed Central

    Kanellos, Georgios; Zhou, Jing; Patel, Hitesh; Ridgway, Rachel A.; Huels, David; Gurniak, Christine B.; Sandilands, Emma; Carragher, Neil O.; Sansom, Owen J.; Witke, Walter; Brunton, Valerie G.; Frame, Margaret C.

    2015-01-01

    Summary Genetic co-depletion of the actin-severing proteins ADF and CFL1 triggers catastrophic loss of adult homeostasis in multiple tissues. There is impaired cell-cell adhesion in skin keratinocytes with dysregulation of E-cadherin, hyperproliferation of differentiated cells, and ultimately apoptosis. Mechanistically, the primary consequence of depleting both ADF and CFL1 is uncontrolled accumulation of contractile actin stress fibers associated with enlarged focal adhesions at the plasma membrane, as well as reduced rates of membrane protrusions. This generates increased intracellular acto-myosin tension that promotes nuclear deformation and physical disruption of the nuclear lamina via the LINC complex that normally connects regulated actin filaments to the nuclear envelope. We therefore describe a pathway involving the actin-severing proteins ADF and CFL1 in regulating the dynamic turnover of contractile actin stress fibers, and this is vital to prevent the nucleus from being damaged by actin contractility, in turn preserving cell survival and tissue homeostasis. PMID:26655907

  10. Design and Validation of Optimized Feedforward with Robust Feedback Control of a Nuclear Reactor

    SciTech Connect

    Shaffer, Roman; He Weidong; Edwards, Robert M.

    2004-08-15

    Design applications for robust feedback and optimized feedforward control, with confirming results from experiments conducted on the Pennsylvania State University TRIGA reactor, are presented. The combination of feedforward and feedback control techniques complement each other in that robust control offers guaranteed closed-loop stability in the presence of uncertainties, and optimized feedforward offers an approach to achieving performance that is sometimes limited by overly conservative robust feedback control. The design approach taken in this work combines these techniques by first designing robust feedback control. Alternative methods for specifying a low-order linear model and uncertainty specifications, while seeking as much performance as possible, are discussed and evaluated. To achieve desired performance characteristics, the optimized feedforward control is then computed by using the nominal nonlinear plant model that incorporates the robust feedback control.

  11. Quantum Nuclear Dynamics Pumped and Probed by Ultrafast Polarization Controlled Steering of a Coherent Electronic State in LiH.

    PubMed

    Nikodem, Astrid; Levine, R D; Remacle, F

    2016-05-19

    The quantum wave packet dynamics following a coherent electronic excitation of LiH by an ultrashort, polarized, strong one-cycle infrared optical pulse is computed on several electronic states using a grid method. The coupling to the strong field of the pump and the probe pulses is included in the Hamiltonian used to solve the time-dependent Schrodinger equation. The polarization of the pump pulse allows us to control the localization in time and in space of the nonequilibrium coherent electronic motion and the subsequent nuclear dynamics. We show that transient absorption, resulting from the interaction of the total molecular dipole with the electric fields of the pump and the probe, is a very versatile probe of the different time scales of the vibronic dynamics. It allows probing both the ultrashort, femtosecond time scale of the electronic coherences as well as the longer dozens of femtoseconds time scales of the nuclear motion on the excited electronic states. The ultrafast beatings of the electronic coherences in space and in time are shown to be modulated by the different periods of the nuclear motion. PMID:26928262

  12. Retrograde transfer RNA nuclear import provides a new level of tRNA quality control in Saccharomyces cerevisiae

    PubMed Central

    Kramer, Emily B.; Hopper, Anita K.

    2013-01-01

    In eukaryotes, transfer RNAs (tRNAs) are transcribed in the nucleus yet function in the cytoplasm; thus, tRNA movement within the cell was believed to be unidirectional—from the nucleus to the cytoplasm. It is now known that mature tRNAs also move in a retrograde direction from the cytoplasm to the nucleus via retrograde tRNA nuclear import, a process that is conserved from yeast to vertebrates. The biological significance of this tRNA nuclear import is not entirely clear. We hypothesized that retrograde tRNA nuclear import might function in proofreading tRNAs to ensure that only proper tRNAs reside in the cytoplasm and interact with the translational machinery. Here we identify two major types of aberrant tRNAs in yeast: a 5′, 3′ end-extended, spliced tRNA and hypomodified tRNAs. We show that both types of aberrant tRNAs accumulate in mutant cells that are defective in tRNA nuclear traffic, suggesting that they are normally imported into the nucleus and are repaired or degraded. The retrograde pathway functions in parallel with the cytoplasmic rapid tRNA decay pathway previously demonstrated to monitor tRNA quality, and cells are not viable if they lack both pathways. Our data support the hypothesis that the retrograde process provides a newly discovered level of tRNA quality control as a pathway that monitors both end processing of pre-tRNAs and the modification state of mature tRNAs. PMID:24297920

  13. Erratum to "Mirroring the dynamic magnetic behavior of magnetostrictive Co/(Ag,Cu,Ta) multilayers grown onto rigid and flexible substrates" [J. Magn. Magn. Mater. 393 (2015) 593-599

    NASA Astrophysics Data System (ADS)

    Agra, K.; Gomes, R. R.; Della Pace, R. D.; Dorneles, L. S.; Bohn, F.; Corrêa, M. A.

    2016-01-01

    The correct version of Fig. 3 in J. Magn. Magn. Mater. 393 (2015) 593-599 is presented below. The quasi-static magnetic behavior of the Co/Ta multilayer grown onto flexible substrate (F//(Co/Ta), Fig. 1(f)) is updated, since the experimental results presented for the Co/Ta multilayer grown onto rigid substrate (named R//(Co/Ta)) have been shown in duplicity in the previous published paper.

  14. Radiation exposure and central nervous system cancers: A case-control study among workers at two nuclear facilities

    SciTech Connect

    Carpenter, A.V.; Flanders, W.D.; Frome, E.L.; Crawford-Brown, D.J.; Fry, S.A.

    1987-03-01

    A nested case-control study was conducted among workers employed between 1943 and 1977 at two nuclear facilities to investigate the possible association of primary malignant neoplasms of the central nervous system (CNS) with occupational exposure to ionizing radiation from external and internal sources. Eighty-nine white male and female workers, who according to the information on death certificates dies of primary CNS cancers, were identified as cases. Four matched controls were selected for each case. External radiation exposure data were available from film badge readings for individual workers, whereas radiation dose to lung from internally deposited radionuclides, mainly uranium, was estimated from area and personnel monitoring data and was used in analyses in lieu of the dose to the brain. Matched sets were included in the analyses only if information was available for the case and at least one of the corresponding controls. Thus, the analyses of external radiation included 27 cases and 90 matched controls, and 47 cases and 120 matched controls were analyzed for the effects of radiation from internally deposited uranium. No association was observed between deaths fron CNS cancers and occupational exposure to ionizing radiation from external or internal sources. However, due to the small number of monitored subjects and low doses, a weak association could not be ruled out. 43 refs., 1 fig., 15 tabs.

  15. Basis for and practical methods of controlling painting activities at the Sequoyah Nuclear Plant

    SciTech Connect

    Campbell, R.R.

    1997-08-01

    Sequoyah Nuclear Plant (SQN) follows the guidance presented in Regulatory Guide (R.G.) 1.52, {open_quotes}Design, Testing, and Maintenance Criteria for Atmospheric Cleanup System Air Filtration and Adsorption System Units of Light-Water-Cooled Nuclear Power Plants{close_quotes} in protecting its charcoal filter trains from the effects of painting and other chemical releases. SQN, as well as other nuclear facilities around the country, have the problem of how to address the issue of protection of Engineered Safety Feature (ESF) filter systems from degradation due to communication with airborne hydrocarbons (i.e., primarily paints and solvents). R.G. 1.52 (and a similar statement from R.G. 1.140) states in part,{open_quotes}Testing should be performed ... following painting, fire, or chemical release in any ventilation zone communicating with the system...,{close_quotes} and requires that a test be performed upon any kind of painting or chemical release. This is considered overly restrictive if the activity is minor and in a location remote from the charcoal filters. Charcoal filters used in air cleaning systems are required to filter out radioactive iodine from an airstream before its release from the plant to the environment. Charcoal filters will age with time because of their ability to adsorb many different types of material. This aging affects the charcoal by lowering its iodine retention efficiency, and therefore the charcoal needs to be protected from the effects of chemicals such as paint fumes. 14 refs., 3 tabs.

  16. Environmental control of plant nuclear gene expression by chloroplast redox signals.

    PubMed

    Pfalz, Jeannette; Liebers, Monique; Hirth, Matthias; Grübler, Björn; Holtzegel, Ute; Schröter, Yvonne; Dietzel, Lars; Pfannschmidt, Thomas

    2012-01-01

    Plant photosynthesis takes place in specialized cell organelles, the chloroplasts, which perform all essential steps of this process. The proteins involved in photosynthesis are encoded by genes located on the plastid and nuclear genomes. Proper function and regulation of light harvesting and energy fixation thus requires a tight coordination of the gene expression machineries in the two genetic compartments. This is achieved by a bi-directional exchange of information between nucleus and plastids. Signals emerging from plastids report the functional and developmental state of the organelle to the nucleus and initiate distinct nuclear gene expression profiles, which trigger responses that support or improve plastid functions. Recent research indicated that this signaling is absolutely essential for plant growth and development. Reduction/oxidation (redox) signals from photosynthesis are key players in this information network since they do report functional disturbances in photosynthesis, the primary energy source of plants. Such disturbances are caused by environmental fluctuations for instance in illumination, temperature, or water availability. These environmental changes affect the linear electron flow of photosynthesis and result in changes of the redox state of the components involved [e.g., the plastoquinone (PQ) pool] or coupled to it (e.g., the thioredoxin pool). Thus, the changes in redox state directly reflect the environmental impact and serve as immediate plastidial signals to the nucleus. The triggered responses range from counterbalancing reactions within the physiological range up to severe stress responses including cell death. This review focuses on physiological redox signals from photosynthetic electron transport (PET), their relation to the environment, potential transduction pathways to the nucleus and their impact on nuclear gene expression. PMID:23181068

  17. Environmental control of plant nuclear gene expression by chloroplast redox signals

    PubMed Central

    Pfalz, Jeannette; Liebers, Monique; Hirth, Matthias; Grübler, Björn; Holtzegel, Ute; Schröter, Yvonne; Dietzel, Lars; Pfannschmidt, Thomas

    2012-01-01

    Plant photosynthesis takes place in specialized cell organelles, the chloroplasts, which perform all essential steps of this process. The proteins involved in photosynthesis are encoded by genes located on the plastid and nuclear genomes. Proper function and regulation of light harvesting and energy fixation thus requires a tight coordination of the gene expression machineries in the two genetic compartments. This is achieved by a bi-directional exchange of information between nucleus and plastids. Signals emerging from plastids report the functional and developmental state of the organelle to the nucleus and initiate distinct nuclear gene expression profiles, which trigger responses that support or improve plastid functions. Recent research indicated that this signaling is absolutely essential for plant growth and development. Reduction/oxidation (redox) signals from photosynthesis are key players in this information network since they do report functional disturbances in photosynthesis, the primary energy source of plants. Such disturbances are caused by environmental fluctuations for instance in illumination, temperature, or water availability. These environmental changes affect the linear electron flow of photosynthesis and result in changes of the redox state of the components involved [e.g., the plastoquinone (PQ) pool] or coupled to it (e.g., the thioredoxin pool). Thus, the changes in redox state directly reflect the environmental impact and serve as immediate plastidial signals to the nucleus. The triggered responses range from counterbalancing reactions within the physiological range up to severe stress responses including cell death. This review focuses on physiological redox signals from photosynthetic electron transport (PET), their relation to the environment, potential transduction pathways to the nucleus and their impact on nuclear gene expression. PMID:23181068

  18. CONTROL TESTING OF THE UK NATIONAL NUCLEAR LABORATORY'S RADBALL TECHNOLOGY AT SAVANNAH RIVER NATIONAL LABORATORY

    SciTech Connect

    Farfan, E.

    2009-11-23

    The UK National Nuclear Laboratory (NNL) has developed a remote, non-electrical, radiation-mapping device known as RadBall (patent pending), which offers a means to locate and quantify radiation hazards and sources within contaminated areas of the nuclear industry. To date, the RadBall has been deployed in a number of technology trials in nuclear waste reprocessing plants at Sellafield in the UK. The trials have demonstrated the successful ability of the RadBall technology to be deployed and retrieved from active areas. The positive results from these initial deployment trials and the anticipated future potential of RadBall have led to the NNL partnering with the Savannah River National Laboratory (SRNL) to further underpin and strengthen the technical performance of the technology. RadBall consists of a colander-like outer shell that houses a radiation-sensitive polymer sphere. It has no power requirements and can be positioned in tight or hard-to reach places. The outer shell works to collimate radiation sources and those areas of the polymer sphere that are exposed react, becoming increasingly less transparent, in proportion to the absorbed dose. The polymer sphere is imaged in an optical-CT scanner which produces a high resolution 3D map of optical attenuation coefficients. Subsequent analysis of the optical attenuation maps provides information on the spatial distribution and strength of the sources in a given area forming a 3D characterization of the area of interest. This study completed at SRNL addresses key aspects of the testing of the RadBall technology. The first set of tests was performed at Savannah River Nuclear Solutions Health Physics Instrument Calibration Laboratory (HPICL) using various gamma-ray sources and an x-ray machine with known radiological characteristics. The objective of these preliminary tests was to identify the optimal dose and collimator thickness. The second set of tests involved a highly contaminated hot cell. The objective of

  19. United States-Russian laboratory-to-laboratory cooperation on protection, control, and accounting for naval nuclear materials

    SciTech Connect

    Sukhoruchkin, V.; Yurasov, N.; Goncharenko, Y.; Mullen, M.; McConnell, D.

    1996-12-31

    In March 1995, the Russian Navy contacted safeguards experts at the Kurchatov Institute (KI) and proposed the initiation of work to enhance nuclear materials protection, control, and accounting (MPC and A) at Russian Navy facilities. Because of KI`s successful experience in laboratory-to-laboratory MPC and A cooperation with US Department of Energy Laboratories, the possibility of US participation in the work with the Russian Navy was explored. Several months later, approval was received from the US Government and the Russian Navy to proceed with this work on a laboratory-to-laboratory basis through Kurchatov Institute. As a first step in the cooperation, a planning meeting occurred at KI in September, 1995. Representatives from the US Department of Energy (DOE), the US Department of Defense (DOD), the Russian Navy, and KI discussed several areas for near-term cooperative work, including a vulnerability assessment workshop and a planning study to identify and prioritize near-term MPC and A enhancements that might be implemented at Russian facilities which store or handle unirradiated highly enriched uranium fuel for naval propulsion applications. In subsequent meetings, these early proposals have been further refined and extended. This MPC and A cooperation will now include enhanced protection and control features for storage facilities and refueling service ships, computerized accounting systems for naval fuel, methods and equipment for rapid inventories, improved security of fresh fuel during truck transportation, and training. This paper describes the current status and future plans for MPC and A cooperation for naval nuclear materials.

  20. Synchronization in a PLC/VAX-based control and data-acquisition system of a nuclear-fusion experiment

    NASA Astrophysics Data System (ADS)

    Schmidt, V.; Flor, G.; Hemming, O. N.; Luchetta, A.; Manduchi, G.; Vitturi, S.

    1990-08-01

    This paper describes the concept and implementation details of the synchronization mechanisms used in the control and data-acquisition system of the RFX (Reversed-Field Experiment) nuclear-fusion experimental device, at present under construction in Padova, Italy, within the framework of the co-ordinated nuclear-fusion research programme of the European Communities. The system employs industrial PLCs for the "slow" control and monitoring functions, and a VAX-based CAMAC for the "fast" functions of trigger-signal generation and data acquisition during the experiment pulses. All subsystems communicative via Ethernet, using compatible software protocols. The operational sequence of the complete system is governed by a single state machine implemented on a PLC-based supervisor system. Equivalent "slave" state machines are implemented on all other subsystems (PLC-and VAX-based). These state machines are synchronized by means of the exchange of messages via Ethernet. This paper deals in detail with the following components which are involved in system synchronization: - the Message Exchange System which implements the system-wide exchange of short messages; - the Scheduler programs which implement the state machine on the various computing nodes, and which make use of the Message Exchange System.

  1. Arc-welding process control based on back face thermography: application to the manufacturing of nuclear steam generators

    NASA Astrophysics Data System (ADS)

    Cobo, A.; Mirapeix, J.; Conde, O. M.; García-Allende, P. B.; Madruga, F. J.; López-Higuera, J. M.

    2007-04-01

    The possibility of reducing defects in the arc welding process has attracted research interest, particularly, in the aerospace and nuclear sectors where the resulting weld quality is a major concern and must be assured by costly, time-consuming, non-destructive testing (NDT) procedures. One possible approach is the analysis of a measurand correlated with the formation of defects, from which a control action is derived. Among others, the thermographic analysis of the weld pool and the heat-affected zone have proven to be a useful technique, since the temperature profile of the material being welded has a clear correlation with the process parameters. In this paper, we propose a control system for the submerged-arc welding (SAW) process, based on thermographic imaging of the back face of the joint being welded. In-lab experiments, with simultaneous infrared and a visible imaging, have been performed. Two image analysis techniques are proposed: tracking of the maximum temperature point of the infrared images, and morphological analysis of the visible images. In-lab welding experiments have demonstrated the feasibility of both techniques. They are able to obtain an estimation of the surface temperature and to detect the occurrence of the perforation defect, what has major application for defect detection and reduction in the joining of shell sections of nuclear steam generators.

  2. Electric-stepping-motor tests for a control-drum actuator of a nuclear reactor

    NASA Technical Reports Server (NTRS)

    Kieffer, A. W.

    1972-01-01

    Experimental tests were conducted on two stepping motors for application as reactor control-drum actuators. Various control-drum loads with frictional resistances ranging from approximately zero to 40 N-m and inertias ranging from zero to 0.424 kg-sq m were tested.

  3. Nuclear Technology. Course 28: Welding Inspection. Module 28-8, Filler Metal Control.

    ERIC Educational Resources Information Center

    Espy, John

    This eighth in a series of ten modules for a course titled Welding Inspection describes controls necessary to place the proper electrode or rod at each welding station. More specifically, the module describes use of the American Welding Society specifications, control of weld filler material after receipt from the supplier, and methods of ensuring…

  4. Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis.

    PubMed

    Martínez-Iglesias, Olaia A; Alonso-Merino, Elvira; Gómez-Rey, Sara; Velasco-Martín, Juan Pedro; Martín Orozco, Rosa; Luengo, Enrique; García Martín, Rosa; Ibáñez de Cáceres, Inmaculada; Fernández, Agustín F; Fraga, Mario F; González-Peramato, Pilar; Varona, Constantino; Palacios, José; Regadera, Javier; Aranda, Ana

    2016-01-19

    Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to repressed transcription of genes associated with increased metastasis and poor prognosis in patients. Strikingly, transient NCoR silencing leads to heterochromatinization and stable silencing of the NCoR gene, suggesting that NCoR loss can be propagated, contributing to tumor progression even in the absence of NCoR gene mutations. Down-regulation of the thyroid hormone receptor β1 (TRβ) appears to be associated with cancer onset and progression. We found that expression of TRβ increases NCoR levels and that this induction is essential in mediating inhibition of tumor growth and metastasis by this receptor. Moreover, NCoR is down-regulated in human hepatocarcinomas and in the more aggressive breast cancer tumors, and its expression correlates positively with that of TRβ. These data provide a molecular basis for the anticancer actions of this corepressor and identify NCoR as a potential molecular target for development of novel cancer therapies. PMID:26729869

  5. Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis

    PubMed Central

    Martínez-Iglesias, Olaia A.; Alonso-Merino, Elvira; Gómez-Rey, Sara; Velasco-Martín, Juan Pedro; Martín Orozco, Rosa; Luengo, Enrique; García Martín, Rosa; Ibáñez de Cáceres, Inmaculada; Fernández, Agustín F.; Fraga, Mario F.; González-Peramato, Pilar; Varona, Constantino; Palacios, José; Regadera, Javier; Aranda, Ana

    2016-01-01

    Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to repressed transcription of genes associated with increased metastasis and poor prognosis in patients. Strikingly, transient NCoR silencing leads to heterochromatinization and stable silencing of the NCoR gene, suggesting that NCoR loss can be propagated, contributing to tumor progression even in the absence of NCoR gene mutations. Down-regulation of the thyroid hormone receptor β1 (TRβ) appears to be associated with cancer onset and progression. We found that expression of TRβ increases NCoR levels and that this induction is essential in mediating inhibition of tumor growth and metastasis by this receptor. Moreover, NCoR is down-regulated in human hepatocarcinomas and in the more aggressive breast cancer tumors, and its expression correlates positively with that of TRβ. These data provide a molecular basis for the anticancer actions of this corepressor and identify NCoR as a potential molecular target for development of novel cancer therapies. PMID:26729869

  6. Electron dynamics upon ionization: Control of the timescale through chemical substitution and effect of nuclear motion

    SciTech Connect

    Vacher, Morgane; Bearpark, Michael J.; Robb, Michael A.; Mendive-Tapia, David

    2015-03-07

    Photoionization can generate a non-stationary electronic state, which leads to coupled electron-nuclear dynamics in molecules. In this article, we choose benzene cation as a prototype because vertical ionization of the neutral species leads to a Jahn-Teller degeneracy between ground and first excited states of the cation. Starting with equal populations of ground and first excited states, there is no electron dynamics in this case. However, if we add methyl substituents that break symmetry but do not radically alter the electronic structure, we see charge migration: oscillations in the spin density that we can correlate with particular localized electronic structures, with a period depending on the gap between the states initially populated. We have also investigated the effect of nuclear motion on electron dynamics using a complete active space self-consistent field (CASSCF) implementation of the Ehrenfest method, most previous theoretical studies of electron dynamics having been carried out with fixed nuclei. In toluene cation for instance, simulations where the nuclei are allowed to move show significant differences in the electron dynamics after 3 fs, compared to simulations with fixed nuclei.

  7. Human-factors engineering-control-room design review: Shoreham Nuclear Power Station. Draft audit report

    SciTech Connect

    Peterson, L.R.; Preston-Smith, J.; Savage, J.W.; Rousseau, W.F.

    1981-04-24

    A human factors engineering preliminary design review of the Shoreham control room was performed at the site on March 30 through April 3, 1981. This design review was carried out by a team from the Human Factors Engineering Branch, Division of Human Factors Safety. This report was prepared on the basis of the HFEB's review of the applicant's Preliminary Design Assessment and the human factors engineering design review/audit performed at the site. The presented sections are numbered to conform to the guidelines of the draft version of NUREG-0700. They summarize the teams's observations of the control room design and layout, and of the control room operators' interface with the control room environment.

  8. Organosilica: Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic-Inorganic Hybridization into Frameworks (Adv. Mater. 17/2016).

    PubMed

    Chen, Yu; Shi, Jianlin

    2016-05-01

    Organic-inorganic hybrid materials can combine the advantages of organic and inorganic materials, and overcome their drawbacks accordingly. On page 3235, Y. Chen and J. L. Shi review and discuss research progress on the design, synthesis, structure, and composition control of organic-inorganic hybrid mesoporous organosilica nanoparticles (MONs). Extensive applications of MONs in nanotechnology, mainly in nanomedicine, nanocatalysis and nanofabrication are discussed. PMID:27122112

  9. Objections to nuclear defence

    SciTech Connect

    Blake, N.; Pole, K.

    1984-01-01

    This book presents papers on nuclear deterrence. Topics considered include nuclear warfare, nuclear deterrence and the use of the just war doctrine, political aspects, human survival, moral aspects, the nuclear arms race, the ideology of nuclear deterrence, arms control, proliferation, and public opinion.

  10. Evaluation of training programs and entry-level qualifications for nuclear-power-plant control-room personnel based on the systems approach to training

    SciTech Connect

    Haas, P M; Selby, D L; Hanley, M J; Mercer, R T

    1983-09-01

    This report summarizes results of research sponsored by the US Nuclear Regulatory Commission (NRC) Office of Nuclear Regulatory Research to initiate the use of the Systems Approach to Training in the evaluation of training programs and entry level qualifications for nuclear power plant (NPP) personnel. Variables (performance shaping factors) of potential importance to personnel selection and training are identified, and research to more rigorously define an operationally useful taxonomy of those variables is recommended. A high-level model of the Systems Approach to Training for use in the nuclear industry, which could serve as a model for NRC evaluation of industry programs, is presented. The model is consistent with current publically stated NRC policy, with the approach being followed by the Institute for Nuclear Power Operations, and with current training technology. Checklists to be used by NRC evaluators to assess training programs for NPP control-room personnel are proposed which are based on this model.

  11. Dosage compensation and nuclear organization: cluster to control chromosome-wide gene expression.

    PubMed

    Sharma, Rahul; Meister, Peter

    2016-04-01

    In many species, male and female animals differ in the number of X chromosomes they possess. As a consequence, large scale differences in gene dosage exist between sexes; a phenomenon that is rarely tolerated by the organism for changes in autosome dosage. Several strategies have evolved independently to balance X-linked gene dosage between sexes, named dosage compensation (DC). The molecular basis of DC differs among the three best-studied examples: mammals, fruit fly and nematodes. In this short review, we summarize recent microscopic and chromosome conformation capture data that reveal key features of the compensated X chromosome and highlight the events leading to the establishment of a functional, specialized nuclear compartment, the X domain. PMID:26748388

  12. Effect of nuclear mass on carrier-envelope-phase-controlled electron localization in dissociating molecules

    NASA Astrophysics Data System (ADS)

    Xu, Han; Xu, Tian-Yu; He, Feng; Kielpinski, D.; Sang, R. T.; Litvinyuk, I. V.

    2014-04-01

    We explore the effect of nuclear mass on the laser-driven electron localization process. We dissociate a mixed H2 and D2 target with intense, carrier-envelope-phase (CEP) stable 6 fs laser pulses and detect the products in a reaction microscope. We observe a very strong CEP-dependent asymmetry in proton and deuteron emission for low dissociation energy channels. This asymmetry is stronger for H2 than for D2. We also observe a large CEP offset between the asymmetry spectra for H2 and D2. Our theoretical simulations, based on a one-dimensional two-channel model, agree very well with the asymmetry spectra, but fail to account properly for the phase difference between the two isotopes.

  13. Variable reluctance electric motor for the translation of control rods in a nuclear reactor

    SciTech Connect

    Guedj, F.; Defaucheux, J.; Wiart, A.

    1985-04-02

    In accordance with the invention, the motor includes: a rotor component composed of a shaft of magnetic material provided with regularly spaced projections, and a stator component comprising at least three multipolar stators encircling the shaft consecutively, each polar core having cavities on the shaft side so as to constitute projections of the same width and spacing as those of the shaft, with the spacing between stators being such that the projections of the shaft and those of the polar cores face one another for only one of the stators. A tight casing is arranged to intersect the stator magnetic circuit and magnetic parts extend the polar core to the interior of the casing. Application to nuclear reactors.

  14. Controlling nuclear JAKs and STATs for specific gene activation by IFNγ

    PubMed Central

    Noon-Song, Ezra N.; Ahmed, Chulbul M.; Dabelic, Rea; Canton, Johnathan; Johnson, Howard M.

    2011-01-01

    We previously showed that gamma interferon (IFNγ) and its receptor subunit, IFNGR1, interacted with the promoter region of IFNγ-activated genes along with transcription factor STAT1α. Recent studies have suggested that activated Janus kinases pJAK2 and pJAK1 also played a role in gene activation by phosphorylation of histone H3 on tyrosine 41. This study addresses the question of the role of activated JAKs in specific gene activation by IFNγ. We carried out chromatin immunoprecipitation (ChIP) followed by PCR in IFNγ treated WISH cells and showed association of pJAK1, pJAK2, IFNGR1, and STAT1 on the same DNA sequence of the IRF-1 gene promoter. The β-actin gene, which is not activated by IFNγ, did not show this association. The movement of activated JAK to the nucleus and the IRF-1 promoter was confirmed by the combination of nuclear fractionation, confocal microscopy and DNA precipitation analysis using the biotinylated GAS promoter. Activated JAKs in the nucleus was associated with phosphorylated tyrosine 41 on histone H3 in the region of the GAS promoter. Unphosphorylated JAK2 was found to be constitutively present in the nucleus and was capable of undergoing activation in IFNγ treated cells, most likely via nuclear IFNGR1. Association of pJAK2 and IFNGR1 with histone H3 in IFNγ treated cells was demonstrated by histone H3 immunoprecipitation. Unphosphorylated STAT1 protein was associated with histone H3 of untreated cells. IFNγ treatment resulted in its disassociation and then re-association as pSTAT1. The results suggest a novel role for activated JAKs in epigenetic events for specific gene activation. PMID:21689637

  15. Graphene Films: Synthesis of Graphene Films on Copper Foils by Chemical Vapor Deposition (Adv. Mater. 29/2016).

    PubMed

    Li, Xuesong; Colombo, Luigi; Ruoff, Rodney S

    2016-08-01

    Synthesis of graphene films on copper foils is discussed by X. Li, L. Colombo, and R. S. Ruoff on page 6247. Graphene can grow on metal substrates by chemical vapor deposition of hydrocarbons. Hydrocarbons crack on a metal surface, nucleate, grow, and finally merge to form a continuous graphene film. Copper is one of the best candidates for graphene growth due to the advantages of good control over the graphene thickness, the growth of high-quality graphene, and the ease for graphene transfer, and has been widely used for production of large-area graphene films in both academia and industry. PMID:27478085

  16. Apparatus for controlling coolant level in a liquid-metal-cooled nuclear reactor

    DOEpatents

    Jones, Robert D.

    1978-01-01

    A liquid-metal-cooled fast-breeder reactor which has a thermal liner spaced inwardly of the pressure vessel and includes means for passing bypass coolant through the annulus between the thermal liner and the pressure vessel to insulate the pressure vessel from hot outlet coolant includes control ports in the thermal liner a short distance below the normal operating coolant level in the reactor and an overflow nozzle in the pressure vessel below the control ports connected to an overflow line including a portion at an elevation such that overflow coolant flow is established when the coolant level in the reactor is above the top of the coolant ports. When no makeup coolant is added, bypass flow is inwardly through the control ports and there is no overflow; when makeup coolant is being added, coolant flow through the overflow line will maintain the coolant level.

  17. Individual dose monitoring of the nuclear medicine departments staff controlled by Central Laboratory for Radiological Protection.

    PubMed

    Szewczak, Kamil; Jednoróg, Sławomir; Krajewski, Paweł

    2013-01-01

    Presented paper describes the results of the individual doses measurements for ionizing radiation, carried out by the Laboratory of Individual and Environmental Doses Monitoring (PDIS) of the Central Laboratory for Radiological Protection in Warsaw (CLOR) for the medical staff employees in several nuclear medicine (NM) departments across Poland. In total there are48 NM departments in operation in Poland [1] (consultation in Nuclear Atomic Agency). Presented results were collected over the period from January 2011 to December 2011 at eight NM departments located in Krakow, Warszawa (two departments), Rzeszow (two departments), Opole, Przemysl and Gorzow Wielkopolski. For radiation monitoring three kinds of thermo luminescence dosimeters (TLD) were used. The first TLD h collected information about whole body (C) effective dose, the second dosimeter was mounted in the ring (P) meanwhile the third on the wrist (N) of the tested person. Reading of TLDs was performed in quarterly periods. As a good approximation of effective and equivalent dose assessment of operational quantities both the individual dose equivalent Hp(10) and the Hp(0.07) were used. The analysis of the data was performed using two methods The first method was based on quarterly estimations of Hp(10)q and Hp(0.07)q while the second measured cumulative annual doses Hp(10)a and Hp(0.07)a. The highest recorded value of the radiation dose for quarterly assessments reached 24.4 mSv and was recorded by the wrist type dosimeter worn by a worker involved in source preparation procedure. The mean values of Hp(10)q(C type dosimeter) and Hp(0.07)q (P and N type dosimeter) for all monitored departments were respectively 0.46 mSv and 3.29 mSv. There was a strong correlation between the performed job and the value of the received dose. The highest doses always were absorbed by those staff members who were involved in sources preparation. The highest annual cumulative dose for a particular worker in the considered time

  18. Controlling nuclear JAKs and STATs for specific gene activation by IFN{gamma}

    SciTech Connect

    Noon-Song, Ezra N.; Ahmed, Chulbul M.; Dabelic, Rea; Canton, Johnathan; Johnson, Howard M.

    2011-07-08

    Highlights: {yields} Gamma interferon (IFN{gamma}) and its receptor subunit, IFNGR1, interact with the promoter region of IFN{gamma}-associated genes along with transcription factor STAT1{alpha}. {yields} We show that activated Janus kinases pJAK2 and pJAK1 also associate with IFNGR1 in the nucleus. {yields} The activated Janus kinases are responsible for phosphorylation of tyrosine 41 on histone H3, an important epigenetic event for specific gene activation. -- Abstract: We previously showed that gamma interferon (IFN{gamma}) and its receptor subunit, IFNGR1, interacted with the promoter region of IFN{gamma}-activated genes along with transcription factor STAT1{alpha}. Recent studies have suggested that activated Janus kinases pJAK2 and pJAK1 also played a role in gene activation by phosphorylation of histone H3 on tyrosine 41. This study addresses the question of the role of activated JAKs in specific gene activation by IFN{gamma}. We carried out chromatin immunoprecipitation (ChIP) followed by PCR in IFN{gamma} treated WISH cells and showed association of pJAK1, pJAK2, IFNGR1, and STAT1 on the same DNA sequence of the IRF-1 gene promoter. The {beta}-actin gene, which is not activated by IFN{gamma}, did not show this association. The movement of activated JAK to the nucleus and the IRF-1 promoter was confirmed by the combination of nuclear fractionation, confocal microscopy and DNA precipitation analysis using the biotinylated GAS promoter. Activated JAKs in the nucleus was associated with phosphorylated tyrosine 41 on histone H3 in the region of the GAS promoter. Unphosphorylated JAK2 was found to be constitutively present in the nucleus and was capable of undergoing activation in IFN{gamma} treated cells, most likely via nuclear IFNGR1. Association of pJAK2 and IFNGR1 with histone H3 in IFN{gamma} treated cells was demonstrated by histone H3 immunoprecipitation. Unphosphorylated STAT1 protein was associated with histone H3 of untreated cells. IFN

  19. An experimental investigation of internally ignited fires in nuclear power plant control cabinets: Part 1: Cabinet effects tests

    SciTech Connect

    Chavez, J.M.

    1987-04-01

    A series of full-scale cabinet fire tests was conducted by Sandia National Laboratories for the US Nuclear Regulatory Commission. The cabinet fire tests were prompted by the potential threat to the safety of a nuclear power plant by a cabinet fire in either the control room or in a switchgear type room. The purpose of these cabinet fire tests was to characterize the development and effects of internally ignited cabinet fires as a function of several parameters believed to most influence the burning process. A primary goal of this test program was to test representative and credible configurations and materials. This series of 22 cabinet fire tests demonstrated that fires in either benchboard or vertical cabinets with either IEEE-383 qualified cable or unqualified cable can be ignited and propagate. However, fires with IEEE-383 qualified cable do not propagate as rapidly nor to the extent that unqualified cable does. Furthermore, the results showed that the thermal environment in the test enclosure and adjacent cabinets is not severe enough to result in autoignition of other combustibles; although in some of the larger fires melting of plastic materials may occur. Smoke accumulation in the room appeared to be the most significant problem, as smoke obscured the view in the enclosure within minutes after ignition. Essentially, a cabinet fire can propagate within a single cabinet; however, for the conditions tested it does not appear that the fire poses a threat outside the burning cabinet except the resulting smoke.

  20. The Nuclear Receptor Rev-erbα Controls Circadian Thermogenic Plasticity

    PubMed Central

    Gerhart-Hines, Zachary; Everett, Logan J.; Loro, Emanuele; Briggs, Erika R.; Bugge, Anne; Hou, Catherine; Ferrara, Christine; Seale, Patrick; Pryma, Daniel A.; Khurana, Tejvir S.; Lazar, Mitchell A.

    2013-01-01

    Circadian oscillation of body temperature is a basic, evolutionary-conserved feature of mammalian biology1. Additionally, homeostatic pathways allow organisms to protect their core temperatures in response to cold exposure2. However, the mechanism responsible for coordinating daily body temperature rhythm and adaptability to environmental challenges is unknown. Here we show that the nuclear receptor Rev-erbα, a powerful transcriptional repressor, links circadian and thermogenic networks through the regulation of brown adipose tissue (BAT) function. Mice exposed to cold fare dramatically better at 5 AM (Zeitgeber time 22) when Rev-erbα is barely expressed than at 5 PM (ZT10) when Rev-erbα is abundant. Deletion of Rev-erbα markedly improves cold tolerance at 5 PM, indicating that overcoming Rev-erbα-dependent repression is a fundamental feature of the thermogenic response to cold. Physiological induction of uncoupling protein 1 (UCP1) by cold temperatures is preceded by rapid down-regulation of Rev-erbα in BAT. Rev-erbα represses UCP1 in a brown adipose cell-autonomous manner and BAT UCP1 levels are high in Rev-erbα-null mice even at thermoneutrality. Genetic loss of Rev-erbα also abolishes normal rhythms of body temperature and BAT activity. Thus, Rev-erbα acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands. PMID:24162845