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Sample records for online cone beam

  1. SU-E-J-92: On-Line Cone Beam CT Based Planning for Emergency and Palliative Radiation Therapy

    SciTech Connect

    Held, M; Morin, O; Pouliot, J

    2014-06-01

    Purpose: To evaluate and develop the feasibility of on-line cone beam CT based planning for emergency and palliative radiotherapy treatments. Methods: Subsequent to phantom studies, a case library of 28 clinical megavoltage cone beam CT (MVCBCT) was built to assess dose-planning accuracies on MVCBCT for all anatomical sites. A simple emergency treatment plan was created on the MVCBCT and copied to its reference CT. The agreement between the dose distributions of each image pair was evaluated by the mean dose difference of the dose volume and the gamma index of the central 2D axial plane. An array of popular urgent and palliative cases was also evaluated for imaging component clearance and field-of-view. Results: The treatment cases were categorized into four groups (head and neck, thorax/spine, pelvis and extremities). Dose distributions for head and neck treatments were predicted accurately in all cases with a gamma index of >95% for 2% and 2 mm criteria. Thoracic spine treatments had a gamma index as low as 60% indicating a need for better uniformity correction and tissue density calibration. Small anatomy changes between CT and MVCBCT could contribute to local errors. Pelvis and sacral spine treatment cases had a gamma index between 90% and 98% for 3%/3 mm criteria. The limited FOV became an issue for large pelvis patients. Imaging clearance was difficult for cases where the tumor was positioned far off midline. Conclusion: The MVCBCT based dose planning and delivery approach is feasible in many treatment cases. Dose distributions for head and neck patients are unrestrictedly predictable. Some FOV restrictions apply to other treatment sites. Lung tissue is most challenging for accurate dose calculations given the current imaging filters and corrections. Additional clinical cases for extremities need to be included in the study to assess the full range of site-specific planning accuracies. This work is supported by Siemens.

  2. Dosimetric Impact of Online Correction via Cone-Beam CT-Based Image Guidance for Stereotactic Lung Radiotherapy

    SciTech Connect

    Galerani, Ana Paula; Grills, Inga; Hugo, Geoffrey; Kestin, Larry; Mohammed, Nasiruddin; Chao, K. Kenneth; Suen, Andrew; Martinez, Alvaro; Yan, Di

    2010-12-01

    Purpose: To evaluate the dosimetric impact of online cone-beam computed tomography (CBCT) guided correction in lung stereotactic body radiation therapy (SBRT). Methods and Materials: Twenty planning and 162 CBCT images from 20 patients undergoing lung SBRT were analyzed. The precorrection CBCT (CBCT after patient setup, no couch correction) was registered to planning CT using soft tissue; couch shift was applied, with a second CBCT for verification (postcorrection CBCT). Targets and normal structures were delineated on CBCTs: gross tumor volume (GTV), clinical target volume (CTV), cord, esophagus, lung, proximal bronchial tree, and aorta. Dose distributions on all organs manifested on each CBCT were compared with those planned on the CT. Results: Without CBCT guided target position correction, target dose reduced with respect to treatment plan. Mean and standard deviation of treatment dose discrepancy from the plan were -3.2% (4.9%), -2.1% (4.4%), -6.1% (10.7%), and -3.5% (7%) for GTV D{sub 99%}, GTV D{sub 95%}, CTV D{sub 99%}, and CTV D{sub 95%}, respectively. With CBCT correction, the results were -0.4% (2.6%), 0.1% (1.7%), -0.3% (4.2%), and 0.5% (3%). Mean and standard deviation of the difference in normal organ maximum dose were 2.2% (6.5%) before correction and 2.4% (5.9%) after correction for esophagus; 6.1% (14.1%) and 3.8% (8.1%) for cord; 3.1% (17.5%) and 6.2% (9.8%) for proximal bronchial tree; and 17.7% (19.5%) and 14.1% (17%) for aorta. Conclusion: Online CBCT guidance improves the accuracy of target dose delivery for lung SBRT. However, treatment dose to normal tissue can vary regardless of the correction. Normal tissues should be considered during target registration, according to target proximity.

  3. SU-E-J-47: Comparison of Online Image Registrations of Varian TrueBeam Cone-Beam CT and BrainLab ExacTrac Imaging Systems

    SciTech Connect

    Li, J; Shi, W; Andrews, D; Werner-Wasik, M; Yu, Y; Liu, H

    2015-06-15

    Purpose To compare online image registrations of TrueBeam cone-beam CT (CBCT) and BrainLab ExacTrac imaging systems. Methods Tests were performed on a Varian TrueBeam STx linear accelerator (Version 2.0), which is integrated with a BrainLab ExacTrac imaging system (Version 6.0.5). The study was focused on comparing the online image registrations for translational shifts. A Rando head phantom was placed on treatment couch and immobilized with a BrainLab mask. The phantom was shifted by moving the couch translationally for 8 mm with a step size of 1 mm, in vertical, longitudinal, and lateral directions, respectively. At each location, the phantom was imaged with CBCT and ExacTrac x-ray. CBCT images were registered with TrueBeam and ExacTrac online registration algorithms, respectively. And ExacTrac x-ray image registrations were performed. Shifts calculated from different registrations were compared with nominal couch shifts. Results The averages and ranges of absolute differences between couch shifts and calculated phantom shifts obtained from ExacTrac x-ray registration, ExacTrac CBCT registration with default window, ExaxTrac CBCT registration with adjusted window (bone), Truebeam CBCT registration with bone window, and Truebeam CBCT registration with soft tissue window, were: 0.07 (0.02–0.14), 0.14 (0.01–0.35), 0.12 (0.02–0.28), 0.09 (0–0.20), and 0.06 (0–0.10) mm, in vertical direction; 0.06 (0.01–0.12), 0.27 (0.07–0.57), 0.23 (0.02–0.48), 0.04 (0–0.10), and 0.08 (0– 0.20) mm, in longitudinal direction; 0.05 (0.01–0.21), 0.35 (0.14–0.80), 0.25 (0.01–0.56), 0.19 (0–0.40), and 0.20 (0–0.40) mm, in lateral direction. Conclusion The shifts calculated from ExacTrac x-ray and TrueBeam CBCT registrations were close to each other (the differences between were less than 0.40 mm in any direction), and had better agreements with couch shifts than those from ExacTrac CBCT registrations. There were no significant differences between TrueBeam

  4. Cardiac cone-beam CT

    SciTech Connect

    Manzke, Robert . E-mail: robert.manzke@philips.com

    2005-10-15

    This doctoral thesis addresses imaging of the heart with retrospectively gated helical cone-beam computed tomography (CT). A thorough review of the CT reconstruction literature is presented in combination with a historic overview of cardiac CT imaging and a brief introduction to other cardiac imaging modalities. The thesis includes a comprehensive chapter about the theory of CT reconstruction, familiarizing the reader with the problem of cone-beam reconstruction. The anatomic and dynamic properties of the heart are outlined and techniques to derive the gating information are reviewed. With the extended cardiac reconstruction (ECR) framework, a new approach is presented for the heart-rate-adaptive gated helical cardiac cone-beam CT reconstruction. Reconstruction assessment criteria such as the temporal resolution, the homogeneity in terms of the cardiac phase, and the smoothness at cycle-to-cycle transitions are developed. Several reconstruction optimization approaches are described: An approach for the heart-rate-adaptive optimization of the temporal resolution is presented. Streak artifacts at cycle-to-cycle transitions can be minimized by using an improved cardiac weighting scheme. The optimal quiescent cardiac phase for the reconstruction can be determined automatically with the motion map technique. Results for all optimization procedures applied to ECR are presented and discussed based on patient and phantom data. The ECR algorithm is analyzed for larger detector arrays of future cone-beam systems throughout an extensive simulation study based on a four-dimensional cardiac CT phantom. The results of the scientific work are summarized and an outlook proposing future directions is given. The presented thesis is available for public download at www.cardiac-ct.net.

  5. Panoramic cone beam computed tomography

    SciTech Connect

    Chang Jenghwa; Zhou Lili; Wang Song; Clifford Chao, K. S.

    2012-05-15

    Purpose: Cone-beam computed tomography (CBCT) is the main imaging tool for image-guided radiotherapy but its functionality is limited by a small imaging volume and restricted image position (imaged at the central instead of the treatment position for peripheral lesions to avoid collisions). In this paper, the authors present the concept of ''panoramic CBCT,'' which can image patients at the treatment position with an imaging volume as large as practically needed. Methods: In this novel panoramic CBCT technique, the target is scanned sequentially from multiple view angles. For each view angle, a half scan (180 deg. + {theta}{sub cone} where {theta}{sub cone} is the cone angle) is performed with the imaging panel positioned in any location along the beam path. The panoramic projection images of all views for the same gantry angle are then stitched together with the direct image stitching method (i.e., according to the reported imaging position) and full-fan, half-scan CBCT reconstruction is performed using the stitched projection images. To validate this imaging technique, the authors simulated cone-beam projection images of the Mathematical Cardiac Torso (MCAT) thorax phantom for three panoramic views. Gaps, repeated/missing columns, and different exposure levels were introduced between adjacent views to simulate imperfect image stitching due to uncertainties in imaging position or output fluctuation. A modified simultaneous algebraic reconstruction technique (modified SART) was developed to reconstruct CBCT images directly from the stitched projection images. As a gold standard, full-fan, full-scan (360 deg. gantry rotation) CBCT reconstructions were also performed using projection images of one imaging panel large enough to encompass the target. Contrast-to-noise ratio (CNR) and geometric distortion were evaluated to quantify the quality of reconstructed images. Monte Carlo simulations were performed to evaluate the effect of scattering on the image quality and

  6. On-Line Use of Three-Dimensional Marker Trajectory Estimation From Cone-Beam Computed Tomography Projections for Precise Setup in Radiotherapy for Targets With Respiratory Motion

    SciTech Connect

    Worm, Esben S.; Hoyer, Morten; Fledelius, Walther; Nielsen, Jens E.; Larsen, Lars P.; Poulsen, Per R.

    2012-05-01

    Purpose: To develop and evaluate accurate and objective on-line patient setup based on a novel semiautomatic technique in which three-dimensional marker trajectories were estimated from two-dimensional cone-beam computed tomography (CBCT) projections. Methods and Materials: Seven treatment courses of stereotactic body radiotherapy for liver tumors were delivered in 21 fractions in total to 6 patients by a linear accelerator. Each patient had two to three gold markers implanted close to the tumors. Before treatment, a CBCT scan with approximately 675 two-dimensional projections was acquired during a full gantry rotation. The marker positions were segmented in each projection. From this, the three-dimensional marker trajectories were estimated using a probability based method. The required couch shifts for patient setup were calculated from the mean marker positions along the trajectories. A motion phantom moving with known tumor trajectories was used to examine the accuracy of the method. Trajectory-based setup was retrospectively used off-line for the first five treatment courses (15 fractions) and on-line for the last two treatment courses (6 fractions). Automatic marker segmentation was compared with manual segmentation. The trajectory-based setup was compared with setup based on conventional CBCT guidance on the markers (first 15 fractions). Results: Phantom measurements showed that trajectory-based estimation of the mean marker position was accurate within 0.3 mm. The on-line trajectory-based patient setup was performed within approximately 5 minutes. The automatic marker segmentation agreed with manual segmentation within 0.36 {+-} 0.50 pixels (mean {+-} SD; pixel size, 0.26 mm in isocenter). The accuracy of conventional volumetric CBCT guidance was compromised by motion smearing ({<=}21 mm) that induced an absolute three-dimensional setup error of 1.6 {+-} 0.9 mm (maximum, 3.2) relative to trajectory-based setup. Conclusions: The first on-line clinical use of

  7. Cone-Beam Computed Tomography for On-Line Image Guidance of Lung Stereotactic Radiotherapy: Localization, Verification, and Intrafraction Tumor Position

    SciTech Connect

    Purdie, Thomas G. . E-mail: Tom.Purdie@rmp.uhn.on.ca; Bissonnette, Jean-Pierre; Franks, Kevin; Bezjak, Andrea; Payne, David; Sie, Fanny; Sharpe, Michael B.; Jaffray, David A.

    2007-05-01

    Purpose: Cone-beam computed tomography (CBCT) in-room imaging allows accurate inter- and intrafraction target localization in stereotactic body radiotherapy of lung tumors. Methods and Materials: Image-guided stereotactic body radiotherapy was performed in 28 patients (89 fractions) with medically inoperable Stage T1-T2 non-small-cell lung carcinoma. The targets from the CBCT and planning data set (helical or four-dimensional CT) were matched on-line to determine the couch shift required for target localization. Matching based on the bony anatomy was also performed retrospectively. Verification of target localization was done using either megavoltage portal imaging or CBCT imaging; repeat CBCT imaging was used to assess the intrafraction tumor position. Results: The mean three-dimensional tumor motion for patients with upper lesions (n = 21) and mid-lobe or lower lobe lesions (n = 7) was 4.2 and 6.7 mm, respectively. The mean difference between the target and bony anatomy matching using CBCT was 6.8 mm (SD, 4.9, maximum, 30.3); the difference exceeded 13.9 mm in 10% of the treatment fractions. The mean residual error after target localization using CBCT imaging was 1.9 mm (SD, 1.1, maximum, 4.4). The mean intrafraction tumor deviation was significantly greater (5.3 mm vs. 2.2 mm) when the interval between localization and repeat CBCT imaging (n = 8) exceeded 34 min. Conclusion: In-room volumetric imaging, such as CBCT, is essential for target localization accuracy in lung stereotactic body radiotherapy. Imaging that relies on bony anatomy as a surrogate of the target may provide erroneous results in both localization and verification.

  8. Correction for ‘artificial’ electron disequilibrium due to cone-beam CT density errors: implications for on-line adaptive stereotactic body radiation therapy of lung

    NASA Astrophysics Data System (ADS)

    Disher, Brandon; Hajdok, George; Wang, An; Craig, Jeff; Gaede, Stewart; Battista, Jerry J.

    2013-06-01

    Cone-beam computed tomography (CBCT) has rapidly become a clinically useful imaging modality for image-guided radiation therapy. Unfortunately, CBCT images of the thorax are susceptible to artefacts due to scattered photons, beam hardening, lag in data acquisition, and respiratory motion during a slow scan. These limitations cause dose errors when CBCT image data are used directly in dose computations for on-line, dose adaptive radiation therapy (DART). The purpose of this work is to assess the magnitude of errors in CBCT numbers (HU), and determine the resultant effects on derived tissue density and computed dose accuracy for stereotactic body radiation therapy (SBRT) of lung cancer. Planning CT (PCT) images of three lung patients were acquired using a Philips multi-slice helical CT simulator, while CBCT images were obtained with a Varian On-Board Imaging system. To account for erroneous CBCT data, three practical correction techniques were tested: (1) conversion of CBCT numbers to electron density using phantoms, (2) replacement of individual CBCT pixel values with bulk CT numbers, averaged from PCT images for tissue regions, and (3) limited replacement of CBCT lung pixels values (LCT) likely to produce artificial lateral electron disequilibrium. For each corrected CBCT data set, lung SBRT dose distributions were computed for a 6 MV volume modulated arc therapy (VMAT) technique within the Philips Pinnacle treatment planning system. The reference prescription dose was set such that 95% of the planning target volume (PTV) received at least 54 Gy (i.e. D95). Further, we used the relative depth dose factor as an a priori index to predict the effects of incorrect low tissue density on computed lung dose in regions of severe electron disequilibrium. CT number profiles from co-registered CBCT and PCT patient lung images revealed many reduced lung pixel values in CBCT data, with some pixels corresponding to vacuum (-1000 HU). Similarly, CBCT data in a plastic lung

  9. Correction for 'artificial' electron disequilibrium due to cone-beam CT density errors: implications for on-line adaptive stereotactic body radiation therapy of lung.

    PubMed

    Disher, Brandon; Hajdok, George; Wang, An; Craig, Jeff; Gaede, Stewart; Battista, Jerry J

    2013-06-21

    Cone-beam computed tomography (CBCT) has rapidly become a clinically useful imaging modality for image-guided radiation therapy. Unfortunately, CBCT images of the thorax are susceptible to artefacts due to scattered photons, beam hardening, lag in data acquisition, and respiratory motion during a slow scan. These limitations cause dose errors when CBCT image data are used directly in dose computations for on-line, dose adaptive radiation therapy (DART). The purpose of this work is to assess the magnitude of errors in CBCT numbers (HU), and determine the resultant effects on derived tissue density and computed dose accuracy for stereotactic body radiation therapy (SBRT) of lung cancer. Planning CT (PCT) images of three lung patients were acquired using a Philips multi-slice helical CT simulator, while CBCT images were obtained with a Varian On-Board Imaging system. To account for erroneous CBCT data, three practical correction techniques were tested: (1) conversion of CBCT numbers to electron density using phantoms, (2) replacement of individual CBCT pixel values with bulk CT numbers, averaged from PCT images for tissue regions, and (3) limited replacement of CBCT lung pixels values (LCT) likely to produce artificial lateral electron disequilibrium. For each corrected CBCT data set, lung SBRT dose distributions were computed for a 6 MV volume modulated arc therapy (VMAT) technique within the Philips Pinnacle treatment planning system. The reference prescription dose was set such that 95% of the planning target volume (PTV) received at least 54 Gy (i.e. D95). Further, we used the relative depth dose factor as an a priori index to predict the effects of incorrect low tissue density on computed lung dose in regions of severe electron disequilibrium. CT number profiles from co-registered CBCT and PCT patient lung images revealed many reduced lung pixel values in CBCT data, with some pixels corresponding to vacuum (-1000 HU). Similarly, CBCT data in a plastic lung

  10. Comparison of Localization Performance with Implanted Fiducial Markers and Cone-Beam Computed Tomography for On-line Image-Guided Radiotherapy of the Prostate

    PubMed Central

    Moseley, Douglas J; White, Elizabeth A; Wiltshire, Kirsty L; Rosewall, Tara; Sharpe, Michael B; Siewerdsen, Jeffrey H; Bissonnette, Jean-Pierre; Gospodarowicz, Mary; Warde, Padraig; Catton, Charles N; Jaffray, David A

    2007-01-01

    Purpose To assess the accuracy of kV cone-beam CT (CBCT) based setup corrections as compared to orthogonal MV portal image-based corrections for patients undergoing external-beam radiotherapy of the prostate. Method and Materials Daily cone-beam CT volumetric images were acquired after setup for patients with three intra-prostatic fiducial markers. The estimated couch shifts were compared retrospectively to patient adjustments based on two orthogonal MV portal images (the current clinical standard of care in our institution). The CBCT soft-tissue based shifts were also estimated by digitally removing the gold markers in each projection to suppress the artifacts in the reconstructed volumes. A total of 256 volumetric images for 15 patients were analyzed. Results The Pearson coefficient of correlation for the patient position shifts using fiducial markers in MV vs kV was (R2 = 0.95, 0.84, 0.81) in the L/R, A/P and S/I directions respectively. The correlation using soft-tissue matching was ((R2 = 0.90, 0.49, 0.51) in the L/R, A/P and S/I directions. A Bland-Altman analysis showed no significant trends in the data. The percentage of shifts within a +/−3mm tolerance (the clinical action level) was (99.7, 95.5, 91.3) for fiducial marker matching and (99.5, 70.3, 78.4) for soft-tissue matching. Conclusions Cone-beam CT is an accurate and precise tool for image-guidance. It provides an equivalent means of patient setup correction for prostate patients with implanted gold fiducial markers. Use of the additional information provided by the visualization of soft-tissue structures is an active area of research. PMID:17293243

  11. Funnel cone for focusing intense ion beams on a target

    SciTech Connect

    Bieniosek, F.M.; Henestroza, E.; Ni, P.

    2009-10-05

    We describe a funnel cone for concentrating an ion beam on a target. The cone utilizes the reflection characteristic of ion beams on solid walls to focus the incident beam andincrease beam intensity on target. The cone has been modeled with the TRIM code. A prototype has been tested and installed for use in the 350-keV K+ NDCX target chamber.

  12. Dedicated Cone-Beam CT System for Extremity Imaging

    PubMed Central

    Al Muhit, Abdullah; Zbijewski, Wojciech; Thawait, Gaurav K.; Stayman, J. Webster; Packard, Nathan; Senn, Robert; Yang, Dong; Foos, David H.; Yorkston, John; Siewerdsen, Jeffrey H.

    2014-01-01

    Purpose To provide initial assessment of image quality and dose for a cone-beam computed tomographic (CT) scanner dedicated to extremity imaging. Materials and Methods A prototype cone-beam CT scanner has been developed for imaging the extremities, including the weight-bearing lower extremities. Initial technical assessment included evaluation of radiation dose measured as a function of kilovolt peak and tube output (in milliampere seconds), contrast resolution assessed in terms of the signal difference–to-noise ratio (SDNR), spatial resolution semiquantitatively assessed by using a line-pair module from a phantom, and qualitative evaluation of cadaver images for potential diagnostic value and image artifacts by an expert CT observer (musculoskeletal radiologist). Results The dose for a nominal scan protocol (80 kVp, 108 mAs) was 9 mGy (absolute dose measured at the center of a CT dose index phantom). SDNR was maximized with the 80-kVp scan technique, and contrast resolution was sufficient for visualization of muscle, fat, ligaments and/or tendons, cartilage joint space, and bone. Spatial resolution in the axial plane exceeded 15 line pairs per centimeter. Streaks associated with x-ray scatter (in thicker regions of the patient—eg, the knee), beam hardening (about cortical bone—eg, the femoral shaft), and cone-beam artifacts (at joint space surfaces oriented along the scanning plane—eg, the interphalangeal joints) presented a slight impediment to visualization. Cadaver images (elbow, hand, knee, and foot) demonstrated excellent visibility of bone detail and good soft-tissue visibility suitable to a broad spectrum of musculoskeletal indications. Conclusion A dedicated extremity cone-beam CT scanner capable of imaging upper and lower extremities (including weight-bearing examinations) provides sufficient image quality and favorable dose characteristics to warrant further evaluation for clinical use. © RSNA, 2013 Online supplemental material is available for

  13. Scatter corrections for cone beam optical CT

    NASA Astrophysics Data System (ADS)

    Olding, Tim; Holmes, Oliver; Schreiner, L. John

    2009-05-01

    Cone beam optical computed tomography (OptCT) employing the VISTA scanner (Modus Medical, London, ON) has been shown to have significant promise for fast, three dimensional imaging of polymer gel dosimeters. One distinct challenge with this approach arises from the combination of the cone beam geometry, a diffuse light source, and the scattering polymer gel media, which all contribute scatter signal that perturbs the accuracy of the scanner. Beam stop array (BSA), beam pass array (BPA) and anti-scatter polarizer correction methodologies have been employed to remove scatter signal from OptCT data. These approaches are investigated through the use of well-characterized phantom scattering solutions and irradiated polymer gel dosimeters. BSA corrected scatter solutions show good agreement in attenuation coefficient with the optically absorbing dye solutions, with considerable reduction of scatter-induced cupping artifact at high scattering concentrations. The application of BSA scatter corrections to a polymer gel dosimeter lead to an overall improvement in the number of pixel satisfying the (3%, 3mm) gamma value criteria from 7.8% to 0.15%.

  14. Cone-beam CT: applications in orthodontics.

    PubMed

    Hechler, Steven L

    2008-10-01

    Radiographic images have always been an important part of orthodontic diagnosis and treatment planning. We have been limited by the two-dimensional nature of these radiographs as we pursue tooth movement in a three-dimensional fashion. This article shows the current and future uses and advantages of cone-beam CT in the practice of orthodontics. The use of this technology in the near future will change the way records are taken and treatment is rendered. With this added diagnostic knowledge, orthodontic treatment will assuredly become not only more high tech but also higher quality. PMID:18805230

  15. Endodontic applications of cone beam computed tomography.

    PubMed

    McClammy, Thomas V

    2014-07-01

    Cone-beam CT (CBCT) has made a dramatic contribution and has been quickly adopted in endodontics. It is a game changer in research and clinical applications. Although CBCT and its application in implantology is well known, the surgical placement of implants is now a factor in endodontics. This article illustrates unique applications of CBCT in implantology in a specialty endodontic facility. Endodontics creates the foundation for restorative dentistry for a healthy tooth, a well-treated endodontically treated tooth, or a well-placed dental implant. CBCT helps make this possible and predictable. PMID:24993923

  16. Cone Beam Computed Tomography - Know its Secrets

    PubMed Central

    Kumar, Mohan; Shanavas, Muhammad; Sidappa, Ashwin; Kiran, Madhu

    2015-01-01

    Cone-beam computed tomography (CBCT) is an advanced imaging modality that has high clinical applications in the field of dentistry. CBCT proved to be a successful investigative modality that has been used for dental and maxillofacial imaging. Radiation exposure dose from CBCT is 10 times less than from conventional CT scans during maxillofacial exposure. Furthermore, CBCT is highly accurate and can provide a three-dimensional volumetric data in axial, sagittal and coronal planes. This article describes the basic technique, difference in CBCT from CT and main clinical applications of CBCT. PMID:25859112

  17. Accuracy of Ultrasound-Based (BAT) Prostate-Repositioning: A Three-Dimensional On-Line Fiducial-Based Assessment With Cone-Beam Computed Tomography

    SciTech Connect

    Boda-Heggemann, Judit Koehler, Frederick Marc; Kuepper, Beate; Wolff, Dirk; Wertz, Hansjoerg; Mai, Sabine; Hesser, Juergen; Lohr, Frank; Wenz, Frederik

    2008-03-15

    Purpose: To assess the accuracy of ultrasound-based repositioning (BAT) before prostate radiation with fiducial-based three-dimensional matching with cone-beam computed tomography (CBCT). Patients and Methods: Fifty-four positionings in 8 patients with {sup 125}I seeds/intraprostatic calcifications as fiducials were evaluated. Patients were initially positioned according to skin marks and after this according to bony structures based on CBCT. Prostate position correction was then performed with BAT. Residual error after repositioning based on skin marks, bony anatomy, and BAT was estimated by a second CBCT based on user-independent automatic fiducial registration. Results: Overall mean value (MV {+-} SD) residual error after BAT based on fiducial registration by CBCT was 0.7 {+-} 1.7 mm in x (group systematic error [M] = 0.5 mm; SD of systematic error [{sigma}] = 0.8 mm; SD of random error [{sigma}] = 1.4 mm), 0.9 {+-} 3.3 mm in y (M = 0.5 mm, {sigma} = 2.2 mm, {sigma} = 2.8 mm), and -1.7 {+-} 3.4 mm in z (M = -1.7 mm, {sigma} = 2.3 mm, {sigma} = 3.0 mm) directions, whereas residual error relative to positioning based on skin marks was 2.1 {+-} 4.6 mm in x (M = 2.6 mm, {sigma} = 3.3 mm, {sigma} = 3.9 mm), -4.8 {+-} 8.5 mm in y (M = -4.4 mm, {sigma} = 3.7 mm, {sigma} = 6.7 mm), and -5.2 {+-} 3.6 mm in z (M = -4.8 mm, {sigma} = 1.7 mm, {sigma} = 3.5mm) directions and relative to positioning based on bony anatomy was 0 {+-} 1.8 mm in x (M = 0.2 mm, {sigma} = 0.9 mm, {sigma} = 1.1 mm), -3.5 {+-} 6.8 mm in y (M = -3.0 mm, {sigma} = 1.8 mm, {sigma} = 3.7 mm), and -1.9 {+-} 5.2 mm in z (M = -2.0 mm, {sigma} = 1.3 mm, {sigma} = 4.0 mm) directions. Conclusions: BAT improved the daily repositioning accuracy over skin marks or even bony anatomy. The results obtained with BAT are within the precision of extracranial stereotactic procedures and represent values that can be achieved with several users with different education levels. If sonographic visibility is insufficient

  18. Accuracy of Ultrasound-Based Image Guidance for Daily Positioning of the Upper Abdomen: An Online Comparison With Cone Beam CT

    SciTech Connect

    Boda-Heggemann, Judit Mennemeyer, Philipp; Wertz, Hansjoerg; Riesenacker, Nadja; Kuepper, Beate; Lohr, Frank; Wenz, Frederik

    2009-07-01

    Purpose: Image-guided intensity-modulated radiotherapy can improve protection of organs at risk when large abdominal target volumes are irradiated. We estimated the daily positioning accuracy of ultrasound-based image guidance for abdominal target volumes by a direct comparison of daily imaging obtained with cone beam computed tomography (CBCT). Methods and Materials: Daily positioning (n = 83 positionings) of 15 patients was completed by using ultrasound guidance after an initial CBCT was obtained. Residual error after ultrasound was estimated by comparison with a second CBCT. Ultrasound image quality was visually rated using a scale of 1 to 4. Results: Of 15 patients, 7 patients had good sonographic imaging quality, 5 patients had satisfactory sonographic quality, and 3 patients were excluded because of unsatisfactory sonographic quality. When image quality was good, residual errors after ultrasound were -0.1 {+-} 3.11 mm in the x direction (left-right; group systematic error M = -0.09 mm; standard deviation [SD] of systematic error, {sigma} = 1.37 mm; SD of the random error, {sigma} = 2.99 mm), 0.93 {+-} 4.31 mm in the y direction (superior-inferior, M = 1.12 mm; {sigma} = 2.96 mm; {sigma} = 3.39 mm), and 0.71 {+-} 3.15 mm in the z direction (anteroposterior; M = 1.01 mm; {sigma} = 2.46 mm; {sigma} = 2.24 mm). For patients with satisfactory image quality, residual error after ultrasound was -0.6 {+-} 5.26 mm in the x (M = 0.07 mm; {sigma} = 5.67 mm; {sigma} = 4.86 mm), 1.76 {+-} 4.92 mm in the y (M = 3.54 mm; {sigma} = 4.1 mm; {sigma} = 5.29 mm), and 1.19 {+-} 4.75 mm in the z (M = 0.82 mm; {sigma} = 2.86 mm; {sigma} = 3.05 mm) directions. Conclusions: In patients from whom good sonographic image quality could be obtained, ultrasound improved daily positioning accuracy. In the case of satisfactory image quality, ultrasound guidance improved accuracy compared to that of skin marks only minimally. If sonographic image quality was unsatisfactory, daily CBCT

  19. Coherent backscattering cone shape depends on the beam size.

    PubMed

    Bi, Renzhe; Dong, Jing; Lee, Kijoon

    2012-09-10

    Coherent backscattering (CBS) is a beautiful physical phenomenon that takes place in a highly scattering medium, which has potential application in noninvasive optical property measurement. The current model that explains the CBS cone shape, however, assumes the incoming beam diameter is infinitely large compared to the transport length. In this paper, we evaluate the effect of a finite scalar light illumination area on the CBS cone, both theoretically and experimentally. The quantitative relationship between laser beam size and the CBS cone shape is established by using two different finite beam models (uniform top hat and Gaussian distribution). A series of experimental data with varying beam diameters is obtained for comparison with the theory. Our study shows the CBS cone shape begins to show distortion when beam size becomes submillimeter, and this effect should not be ignored in general. In biological tissue where a normal large beam CBS cone is too narrow for detection, this small beam CBS may be more advantageous for more accurate and higher resolution tissue characterization. PMID:22968267

  20. Skeletal dosimetry in cone beam computed tomography

    SciTech Connect

    Walters, B. R. B.; Ding, G. X.; Kramer, R.; Kawrakow, I.

    2009-07-15

    Cone beam computed tomography (CBCT) is a relatively new patient imaging technique that has proved invaluable for treatment target verification and patient positioning during image-guided radiotherapy (IGRT). It has been shown that CBCT results in additional dose to bone that may amount to 10% of the prescribed dose. In this study, voxelized human phantoms, FAX06 (adult female) and MAX06 (adult male), are used together with phase-space data collected from a realistic model of a CBCT imager to calculate dose in the red bone marrow (RBM) and bone surface cells (BSCs), the two organs at risk within the bone spongiosa, during simulated head and neck, chest and pelvis CBCT scans. The FAX06/MAX06 phantoms model spongiosa based on micro-CT images, filling the relevant phantom voxels, which are 0.12x0.12x0.12 cm{sup 3}, with 17x17x17 {mu}m{sup 3} microvoxels to form a micromatrix of trabecular bone and bone marrow. FAX06/MAX06 have already been implemented in an EGSnrc-based Monte Carlo code to simulate radiation transport in the phantoms; however, this study required significant modifications of the code to allow use of phase-space data from a simulated CBCT imager as a source and to allow scoring of total dose, RBM dose and BSC dose on a voxel-by-voxel basis. In simulated CBCT scans, the BSC dose is significantly greater than the dose to other organs at risk. For example, in a simulated head and neck scan, the average BSC dose is 25% higher than the average dose to eye lens ({approx}8.3 cGy), and 80% greater than the average dose to brain (5.7 cGy). Average dose to RBM, on the other hand, is typically only {approx}50% of the average BSC dose and less than the dose to other organs at risk (54% of the dose to eye lens and 76% of dose to brain in a head and neck scan). Thus, elevated dose in bone due to CBCT results in elevated BSC dose. This is potentially of concern when using CBCT in conjunction with radiotherapy treatment.

  1. Skeletal dosimetry in cone beam computed tomography.

    PubMed

    Walters, B R B; Ding, G X; Kramer, R; Kawrakow, I

    2009-07-01

    Cone beam computed tomography (CBCT) is a relatively new patient imaging technique that has proved invaluable for treatment target verification and patient positioning during image-guided radiotherapy (IGRT). It has been shown that CBCT results in additional dose to bone that may amount to 10% of the prescribed dose. In this study, voxelized human phantoms, FAX06 (adult female) and MAX06 (adult male), are used together with phase-space data collected from a realistic model of a CBCT imager to calculate dose in the red bone marrow (RBM) and bone surface cells (BSCs), the two organs at risk within the bone spongiosa, during simulated head and neck, chest and pelvis CBCT scans. The FAX06/MAX06 phantoms model spongiosa based on micro-CT images, filling the relevant phantom voxels, which are 0.12 x 0.12 x 0.12 cm3, with 17 x 17 x 17 microm3 microvoxels to form a micromatrix of trabecular bone and bone marrow. FAX06/ MAX06 have already been implemented in an EGSnrc-based Monte Carlo code to simulate radiation transport in the phantoms; however, this study required significant modifications of the code to allow use of phase-space data from a simulated CBCT imager as a source and to allow scoring of total dose, RBM dose and BSC dose on a voxel-by-voxel basis. In simulated CBCT scans, the BSC dose is significantly greater than the dose to other organs at risk. For example, in a simulated head and neck scan, the average BSC dose is 25% higher than the average dose to eye lens (approximately 8.3 cGy), and 80% greater than the average dose to brain (5.7 cGy). Average dose to RBM, on the other hand, is typically only approximately 50% of the average BSC dose and less than the dose to other organs at risk (54% of the dose to eye lens and 76% of dose to brain in a head and neck scan). Thus, elevated dose in bone due to CBCT results in elevated BSC dose. This is potentially of concern when using CBCT in conjunction with radiotherapy treatment. PMID:19673190

  2. Expectation maximization reconstruction for circular orbit cone-beam CT

    NASA Astrophysics Data System (ADS)

    Dong, Baoyu

    2008-03-01

    Cone-beam computed tomography (CBCT) is a technique for imaging cross-sections of an object using a series of X-ray measurements taken from different angles around the object. It has been widely applied in diagnostic medicine and industrial non-destructive testing. Traditional CT reconstructions are limited by many kinds of artifacts, and they give dissatisfactory image. To reduce image noise and artifacts, we propose a statistical iterative approach for cone-beam CT reconstruction. First the theory of maximum likelihood estimation is extended to X-ray scan, and an expectation-maximization (EM) formula is deduced for direct reconstruction of circular orbit cone-beam CT. Then the EM formula is implemented in cone-beam geometry for artifact reduction. EM algorithm is a feasible iterative method, which is based on the statistical properties of Poisson distribution. It can provide good quality reconstructions after a few iterations for cone-beam CT. In the end, experimental results with computer simulated data and real CT data are presented to verify our method is effective.

  3. Automated planning of breast radiotherapy using cone beam CT imaging

    SciTech Connect

    Amit, Guy; Purdie, Thomas G.

    2015-02-15

    Purpose: Develop and clinically validate a methodology for using cone beam computed tomography (CBCT) imaging in an automated treatment planning framework for breast IMRT. Methods: A technique for intensity correction of CBCT images was developed and evaluated. The technique is based on histogram matching of CBCT image sets, using information from “similar” planning CT image sets from a database of paired CBCT and CT image sets (n = 38). Automated treatment plans were generated for a testing subset (n = 15) on the planning CT and the corrected CBCT. The plans generated on the corrected CBCT were compared to the CT-based plans in terms of beam parameters, dosimetric indices, and dose distributions. Results: The corrected CBCT images showed considerable similarity to their corresponding planning CTs (average mutual information 1.0±0.1, average sum of absolute differences 185 ± 38). The automated CBCT-based plans were clinically acceptable, as well as equivalent to the CT-based plans with average gantry angle difference of 0.99°±1.1°, target volume overlap index (Dice) of 0.89±0.04 although with slightly higher maximum target doses (4482±90 vs 4560±84, P < 0.05). Gamma index analysis (3%, 3 mm) showed that the CBCT-based plans had the same dose distribution as plans calculated with the same beams on the registered planning CTs (average gamma index 0.12±0.04, gamma <1 in 99.4%±0.3%). Conclusions: The proposed method demonstrates the potential for a clinically feasible and efficient online adaptive breast IMRT planning method based on CBCT imaging, integrating automation.

  4. Analytical fan-beam and cone-beam reconstruction algorithms with uniform attenuation correction for SPECT

    NASA Astrophysics Data System (ADS)

    Tang, Qiulin; Zeng, Gengsheng L.; Gullberg, Grant T.

    2005-07-01

    In this paper, we developed an analytical fan-beam reconstruction algorithm that compensates for uniform attenuation in SPECT. The new fan-beam algorithm is in the form of backprojection first, then filtering, and is mathematically exact. The algorithm is based on three components. The first one is the established generalized central-slice theorem, which relates the 1D Fourier transform of a set of arbitrary data and the 2D Fourier transform of the backprojected image. The second one is the fact that the backprojection of the fan-beam measurements is identical to the backprojection of the parallel measurements of the same object with the same attenuator. The third one is the stable analytical reconstruction algorithm for uniformly attenuated Radon data, developed by Metz and Pan. The fan-beam algorithm is then extended into a cone-beam reconstruction algorithm, where the orbit of the focal point of the cone-beam imaging geometry is a circle. This orbit geometry does not satisfy Tuy's condition and the obtained cone-beam algorithm is an approximation. In the cone-beam algorithm, the cone-beam data are first backprojected into the 3D image volume; then a slice-by-slice filtering is performed. This slice-by-slice filtering procedure is identical to that of the fan-beam algorithm. Both the fan-beam and cone-beam algorithms are efficient, and computer simulations are presented. The new cone-beam algorithm is compared with Bronnikov's cone-beam algorithm, and it is shown to have better performance with noisy projections.

  5. Comparison of cone beam artifacts reduction: two pass algorithm vs TV-based CS algorithm

    NASA Astrophysics Data System (ADS)

    Choi, Shinkook; Baek, Jongduk

    2015-03-01

    In a cone beam computed tomography (CBCT), the severity of the cone beam artifacts is increased as the cone angle increases. To reduce the cone beam artifacts, several modified FDK algorithms and compressed sensing based iterative algorithms have been proposed. In this paper, we used two pass algorithm and Gradient-Projection-Barzilai-Borwein (GPBB) algorithm to reduce the cone beam artifacts, and compared their performance using structural similarity (SSIM) index. In two pass algorithm, it is assumed that the cone beam artifacts are mainly caused by extreme-density(ED) objects, and therefore the algorithm reproduces the cone beam artifacts(i.e., error image) produced by ED objects, and then subtract it from the original image. GPBB algorithm is a compressed sensing based iterative algorithm which minimizes an energy function for calculating the gradient projection with the step size determined by the Barzilai- Borwein formulation, therefore it can estimate missing data caused by the cone beam artifacts. To evaluate the performance of two algorithms, we used testing objects consisting of 7 ellipsoids separated along the z direction and cone beam artifacts were generated using 30 degree cone angle. Even though the FDK algorithm produced severe cone beam artifacts with a large cone angle, two pass algorithm reduced the cone beam artifacts with small residual errors caused by inaccuracy of ED objects. In contrast, GPBB algorithm completely removed the cone beam artifacts and restored the original shape of the objects.

  6. WE-G-18A-03: Cone Artifacts Correction in Iterative Cone Beam CT Reconstruction

    SciTech Connect

    Yan, H; Folkerts, M; Jiang, S; Jia, X; Wang, X; Bai, T; Lu, W

    2014-06-15

    Purpose: For iterative reconstruction (IR) in cone-beam CT (CBCT) imaging, data truncation along the superior-inferior (SI) direction causes severe cone artifacts in the reconstructed CBCT volume images. Not only does it reduce the effective SI coverage of the reconstructed volume, it also hinders the IR algorithm convergence. This is particular a problem for regularization based IR, where smoothing type regularization operations tend to propagate the artifacts to a large area. It is our purpose to develop a practical cone artifacts correction solution. Methods: We found it is the missing data residing in the truncated cone area that leads to inconsistency between the calculated forward projections and measured projections. We overcome this problem by using FDK type reconstruction to estimate the missing data and design weighting factors to compensate the inconsistency caused by the missing data. We validate the proposed methods in our multi-GPU low-dose CBCT reconstruction system on multiple patients' datasets. Results: Compared to the FDK reconstruction with full datasets, while IR is able to reconstruct CBCT images using a subset of projection data, the severe cone artifacts degrade overall image quality. For head-neck case under a full-fan mode, 13 out of 80 slices are contaminated. It is even more severe in pelvis case under half-fan mode, where 36 out of 80 slices are affected, leading to inferior soft-tissue delineation. By applying the proposed method, the cone artifacts are effectively corrected, with a mean intensity difference decreased from ∼497 HU to ∼39HU for those contaminated slices. Conclusion: A practical and effective solution for cone artifacts correction is proposed and validated in CBCT IR algorithm. This study is supported in part by NIH (1R01CA154747-01)

  7. Cardiac cone-beam CT volume reconstruction using ART

    SciTech Connect

    Nielsen, T.; Manzke, R.; Proksa, R.; Grass, M.

    2005-04-01

    Modern computed tomography systems allow volume imaging of the heart. Up to now, approximately two-dimensional (2D) and 3D algorithms based on filtered backprojection are used for the reconstruction. These algorithms become more sensitive to artifacts when the cone angle of the x-ray beam increases as it is the current trend of computed tomography (CT) technology. In this paper, we investigate the potential of iterative reconstruction based on the algebraic reconstruction technique (ART) for helical cardiac cone-beam CT. Iterative reconstruction has the advantages that it takes the cone angle into account exactly and that it can be combined with retrospective cardiac gating fairly easily. We introduce a modified ART algorithm for cardiac CT reconstruction. We apply it to clinical cardiac data from a 16-slice CT scanner and compare the images to those obtained with a current analytical reconstruction method. In a second part, we investigate the potential of iterative reconstruction for a large area detector with 256 slices. For the clinical cases, iterative reconstruction produces excellent images of diagnostic quality. For the large area detector, iterative reconstruction produces images superior to analytical reconstruction in terms of cone-beam artifacts.

  8. Legal considerations in the use of cone beam computer tomography imaging.

    PubMed

    Zinman, Edwin J; White, Stuart C; Tetradis, Sotirios

    2010-01-01

    Cone beam computed tomography imaging represents a paradigm shift for enhancing diagnosis and treatment planning. Questions regarding cone beam computed tomography's associated legal responsibility are addressed, including cone beam computed tomography necessity, recognition of pathosis in the scan's entire volume, adequate training, informed consent and/or refusal and current court status of cone beam computed tomography. Judicious selection and prudent use of cone beam computed tomography technology to protect and promote patient safety and efficacious treatment complies with the standard of care. PMID:20178227

  9. Analytically derived weighting factors for transmission tomography cone beam projections

    NASA Astrophysics Data System (ADS)

    Yao, Weiguang; Leszczynski, Konrad

    2009-02-01

    Weighting factors, which define the contributions of individual voxels of a 3D object to individual projection elements (pixels) on the detector, are the basic elements required in iterative tomographic reconstructions from transmission projections. Exact or as accurate as possible values for weighting factors are required in high-resolution reconstructions. Geometric complexity of the problem, however, makes it difficult to obtain exact weighting factor values. In this work, we derive an analytical expression for the weighting factors in cone beam projection geometry. The resulting formula is validated and applied to reconstruction from mega and kilovoltage x-ray cone beam projections. The reconstruction speed and accuracy are significantly improved by using the weighting factor values.

  10. Cone beam computed tomography in Endodontics - a review.

    PubMed

    Patel, S; Durack, C; Abella, F; Shemesh, H; Roig, M; Lemberg, K

    2015-01-01

    Cone beam computed tomography (CBCT) produces undistorted three-dimensional information of the maxillofacial skeleton, including the teeth and their surrounding tissues with a lower effective radiation dose than computed tomography. The aim of this paper is to: (i) review the current literature on the applications and limitations of CBCT; (ii) make recommendations for the use of CBCT in Endodontics; (iii) highlight areas of further research of CBCT in Endodontics. PMID:24697513

  11. Cone Beam Computed Tomography for the Dental Implant Patient.

    PubMed

    Klokkevold, Perry R

    2015-09-01

    Cone beam computed tomography offers many advantages over 2-D imaging for the evaluation of potential implant sites. With the use of CBCT scans becoming more commonplace, it is important for clinicians to be knowledgeable and to use this new technology appropriately and judiciously. The purpose of this article is to describe the advantages and limitations of CBCT imaging for the presurgical and postsurgical evaluations of implant treatment and assessment of implant-related complications. PMID:26820009

  12. Coherent Cone-Beam X-ray Microscopy

    SciTech Connect

    Harder, R.; Xiao, X.

    2011-09-09

    A novel full-field imaging method using the (111) Bragg diffraction of a sub-micron gold crystal as the divergent cone-beam for sample illumination is reported. The divergence of the illumination allows for very high magnification, limited only by the achievable ratio of the crystal-to-sample and sample-to-detector distances. In this case an x-ray magnification of approximately 115 was achieved.

  13. Use of Cone Beam Computed Tomography in Endodontics

    PubMed Central

    Scarfe, William C.; Levin, Martin D.; Gane, David; Farman, Allan G.

    2009-01-01

    Cone Beam Computed Tomography (CBCT) is a diagnostic imaging modality that provides high-quality, accurate three-dimensional (3D) representations of the osseous elements of the maxillofacial skeleton. CBCT systems are available that provide small field of view images at low dose with sufficient spatial resolution for applications in endodontic diagnosis, treatment guidance, and posttreatment evaluation. This article provides a literature review and pictorial demonstration of CBCT as an imaging adjunct for endodontics. PMID:20379362

  14. Orthogonal-rotating tetrahedral scanning for cone-beam CT

    NASA Astrophysics Data System (ADS)

    Ye, Ivan B.; Wang, Ge

    2012-10-01

    In this article, a cone-beam CT scanning mode is designed assuming four x-ray sources and a spherical sample. The x-ray sources are mounted at the vertices of a regular tetrahedron. On the circumsphere of the tetrahedron, four detection panels are mounted opposite to each vertex. To avoid x-ray interference, the largest half angle of each x-ray cone beam is 27°22', while the radius of the largest ball fully covered by all the cone beams is 0.460, when the radius of the circumsphere is 1. Several scanning schemes are proposed which consist of two rotations about orthogonal axes, such that each quarter turn provides sufficient data for theoretically exact and stable reconstruction. This design can be used in biomedical or industrial settings, such as when a sequence of reconstructions of an object is desired. Similar scanning schemes based on other regular or irregular polyhedra and various rotation speeds are also discussed.

  15. Exact helical reconstruction using native cone-beam geometries

    NASA Astrophysics Data System (ADS)

    Noo, Frédéric; Pack, Jed; Heuscher, Dominic

    2003-12-01

    This paper is about helical cone-beam reconstruction using the exact filtered backprojection formula recently suggested by Katsevich (2002a Phys. Med. Biol. 47 2583-97). We investigate how to efficiently and accurately implement Katsevich's formula for direct reconstruction from helical cone-beam data measured in two native geometries. The first geometry is the curved detector geometry of third-generation multi-slice CT scanners, and the second geometry is the flat detector geometry of C-arms systems and of most industrial cone-beam CT scanners. For each of these two geometries, we determine processing steps to be applied to the measured data such that the final outcome is an implementation of the Katsevich formula. These steps are first described using continuous-form equations, disregarding the finite detector resolution and the source position sampling. Next, techniques are presented for implementation of these steps with finite data sampling. The performance of these techniques is illustrated for the curved detector geometry of third-generation CT scanners, with 32, 64 and 128 detector rows. In each case, resolution and noise measurements are given along with reconstructions of the FORBILD thorax phantom.

  16. A One-Step Cone-Beam CT-Enabled Planning-to-Treatment Model for Palliative Radiotherapy-From Development to Implementation

    SciTech Connect

    Wong, Rebecca K.S.; Letourneau, Daniel; Varma, Anita; Bissonnette, Jean Pierre; Fitzpatrick, David; Grabarz, Daniel; Elder, Christine; Martin, Melanie; Bezjak, Andrea; Panzarella, Tony; Gospodarowicz, Mary; Jaffray, David A.

    2012-11-01

    Purpose: To develop a cone-beam computed tomography (CT)-enabled one-step simulation-to-treatment process for the treatment of bone metastases. Methods and Materials: A three-phase prospective study was conducted. Patients requiring palliative radiotherapy to the spine, mediastinum, or abdomen/pelvis suitable for treatment with simple beam geometry ({<=}2 beams) were accrued. Phase A established the accuracy of cone-beam CT images for the purpose of gross tumor target volume (GTV) definition. Phase B evaluated the feasibility of implementing the cone-beam CT-enabled planning process at the treatment unit. Phase C evaluated the online cone-beam CT-enabled process for the planning and treatment of patients requiring radiotherapy for bone metastases. Results: Eighty-four patients participated in this study. Phase A (n = 9) established the adequacy of cone-beam CT images for target definition. Phase B (n = 45) established the quality of treatment plans to be adequate for clinical implementation for bone metastases. When the process was applied clinically in bone metastases (Phase C), the degree of overlap between planning computed tomography (PCT) and cone-beam CT for GTV and between PCT and cone-beam CT for treatment field was 82% {+-} 11% and 97% {+-} 4%, respectively. The oncologist's decision to accept the plan under a time-pressured environment remained of high quality, with the cone-beam CT-generated treatment plan delivering at least 90% of the prescribed dose to 100% {+-} 0% of the cone-beam CT planning target volume (PTV). With the assumption that the PCT PTV is the gold-standard target, the cone-beam CT-generated treatment plan delivered at least 90% and at least 95% of dose to 98% {+-} 2% and 97% {+-} 5% of the PCT PTV, respectively. The mean time for the online planning and treatment process was 32.7 {+-} 4.0 minutes. Patient satisfaction was high, with a trend for superior satisfaction with the cone-beam CT-enabled process. Conclusions: The cone-beam CT

  17. Fundamentals of cone beam computed tomography for a prosthodontist.

    PubMed

    John, George Puthenpurayil; Joy, Tatu Elenjickal; Mathew, Justin; Kumar, Vinod R B

    2015-01-01

    Cone beam computed tomography (CBCT, also referred to as C-arm computed tomography [CT], cone beam volume CT, or flat panel CT) is a medical imaging technique of X-ray CT where the X-rays are divergent, forming a cone.[1] CBCT systems have been designed for imaging hard tissues of the maxillofacial region. CBCT is capable of providing sub-millimeter resolution in images of high diagnostic quality, with short scanning times (10-70 s) and radiation dosages reportedly up to 15-100 times lower than those of conventional CT scans. Increasing availability of this technology provides the dental clinician with an imaging modality capable of providing a three-dimensional representation of the maxillofacial skeleton with minimal distortion. The aim of this article is to sensitize the Prosthodontist to CBCT technology, provide an overview of currently available maxillofacial CBCT systems and review the specific application of various CBCT display modes to clinical Prosthodontic practice. A MEDLINE search for relevant articles in this specific area of interest was conducted. The selected articles were critically reviewed and the data acquired were systematically compiled. PMID:26929479

  18. Fundamentals of cone beam computed tomography for a prosthodontist

    PubMed Central

    John, George Puthenpurayil; Joy, Tatu Elenjickal; Mathew, Justin; Kumar, Vinod R. B.

    2015-01-01

    Cone beam computed tomography (CBCT, also referred to as C-arm computed tomography [CT], cone beam volume CT, or flat panel CT) is a medical imaging technique of X-ray CT where the X-rays are divergent, forming a cone.[1] CBCT systems have been designed for imaging hard tissues of the maxillofacial region. CBCT is capable of providing sub-millimeter resolution in images of high diagnostic quality, with short scanning times (10–70 s) and radiation dosages reportedly up to 15–100 times lower than those of conventional CT scans. Increasing availability of this technology provides the dental clinician with an imaging modality capable of providing a three-dimensional representation of the maxillofacial skeleton with minimal distortion. The aim of this article is to sensitize the Prosthodontist to CBCT technology, provide an overview of currently available maxillofacial CBCT systems and review the specific application of various CBCT display modes to clinical Prosthodontic practice. A MEDLINE search for relevant articles in this specific area of interest was conducted. The selected articles were critically reviewed and the data acquired were systematically compiled. PMID:26929479

  19. Half-cone beam collimation for triple-camera SPECT systems

    SciTech Connect

    Li, Jianying; Jaszczak, R.J.; Van Mullekom, A. |

    1996-03-01

    Cone-beam collimators provide increased sensitivity at similar resolution compared to other collimators. The use of cone-beam collimators for brain imaging with triple-camera SPECT systems, however, results in truncation of the base of the brain because of clearance of the shoulders. A half-cone beam collimator does not have the problem of truncation. The objective of this study was to compare the performance characteristics of half-cone beam with parallel-beam and fan-beam collimators with similar resolution characteristics for SPECT imaging of the brain. A half-cone beam collimator with the focal point located towards the base of the brain was built for a triple-camera SPECT system. Spatial resolutions and sensitivities of three collimators were measured. When 10-cm from the collimator surface, the planar spatial resolutions FWHM in mm (point source sensitivities in cps-MBq) for half-cone beam, fan-beam and parallel-beam collimators were 5.2 (85.6), 5.1 (55.6) and 5.9 (39.7), respectively. Image quality was evaluated using a three-dimensional Hoffman brain phantom and patient data. The deeper gray matter were more clearly visualized in the half-cone beam scans. Half-cone beam collimation provides higher sensitivity and offers the potential for improved brain imaging compared with parallel-beam and fan-beam collimation when used with a triple-camera SPECT system. 23 refs., 9 figs., 1 tab.

  20. Commissioning kilovoltage cone-beam CT beams in a radiation therapy treatment planning system.

    PubMed

    Alaei, Parham; Spezi, Emiliano

    2012-01-01

    The feasibility of accounting of the dose from kilovoltage cone-beam CT in treatment planning has been discussed previously for a single cone-beam CT (CBCT) beam from one manufacturer. Modeling the beams and computing the dose from the full set of beams produced by a kilovoltage cone-beam CT system requires extensive beam data collection and verification, and is the purpose of this work. The beams generated by Elekta X-ray volume imaging (XVI) kilovoltage CBCT (kV CBCT) system for various cassettes and filters have been modeled in the Philips Pinnacle treatment planning system (TPS) and used to compute dose to stack and anthropomorphic phantoms. The results were then compared to measurements made using thermoluminescent dosimeters (TLDs) and Monte Carlo (MC) simulations. The agreement between modeled and measured depth-dose and cross profiles is within 2% at depths beyond 1 cm for depth-dose curves, and for regions within the beam (excluding penumbra) for cross profiles. The agreements between TPS-calculated doses, TLD measurements, and Monte Carlo simulations are generally within 5% in the stack phantom and 10% in the anthropomorphic phantom, with larger variations observed for some of the measurement/calculation points. Dose computation using modeled beams is reasonably accurate, except for regions that include bony anatomy. Inclusion of this dose in treatment plans can lead to more accurate dose prediction, especially when the doses to organs at risk are of importance. PMID:23149789

  1. Achromatic vector vortex beams from a glass cone

    PubMed Central

    Radwell, N.; Hawley, R. D.; Götte, J. B.; Franke-Arnold, S.

    2016-01-01

    The reflection of light is governed by the laws first described by Augustin-Jean Fresnel: on internal reflection, light acquires a phase shift, which depends on its polarization direction with respect to the plane of incidence. For a conical reflector, the cylindrical symmetry is echoed in an angular variation of this phase shift, allowing us to create light modes with phase and polarization singularities. Here we observe the phase and polarization profiles of light that is back reflected from a solid glass cone and, in the case of circular input light, discover that not only does the beam contain orbital angular momentum but can trivially be converted to a radially polarized beam. Importantly, the Fresnel coefficients are reasonably stable across the visible spectrum, which we demonstrate by measuring white light polarization profiles. This discovery provides a highly cost-effective technique for the generation of broadband orbital angular momentum and radially polarized beams. PMID:26861191

  2. Helical cone beam CT with an asymmetrical detector

    SciTech Connect

    Zamyatin, Alexander A.; Taguchi, Katsuyuki; Silver, Michael D.

    2005-10-15

    If a multislice or other area detector is shifted to one side to cover a larger field of view, then the data are truncated on one side. We propose a method to restore the missing data in helical cone-beam acquisitions that uses measured data on the longer side of the asymmetric detector array. The method is based on the idea of complementary rays, which is well known in fan beam geometry; in this paper we extend this concept to the cone-beam case. Different cases of complementary data coverage and dependence on the helical pitch are considered. The proposed method is used in our prototype 16-row CT scanner with an asymmetric detector and a 700 mm field of view. For evaluation we used scanned body phantom data and computer-simulated data. To simulate asymmetric truncation, the full, symmetric datasets were truncated by dropping either 22.5% or 45% from one side of the detector. Reconstructed images from the prototype scanner with the asymmetrical detector show excellent image quality in the extended field of view. The proposed method allows flexible helical pitch selection and can be used with overscan, short-scan, and super-short-scan reconstructions.

  3. Superior performance of cone beam tomography in detecting a calcaneus fracture

    PubMed Central

    Lohse, Christian; Catala-Lehnen, Philip; Regier, Marc; Heiland, Max

    2015-01-01

    Cone beam computed tomography is a state-of-the-art imaging tool, initially developed for dental and maxillofacial application. With its high resolution and low radiation dose, cone beam tomography has been expanding its application fields, for example, to diagnosis of traumata and fractures in the head and neck area. In this study, we demonstrate superior and satisfactory performance of cone beam tomography for the imaging of a calcaneus fracture in comparison to conventional X-ray and computed tomography. PMID:26605132

  4. Application of cone-beam CT in the office setting.

    PubMed

    Thomas, Steven L

    2008-10-01

    The decision to incorporate cone-beam CT (CBCT) into a dental practice is one that requires serious consideration and careful planning. In the early days of the technology, fewer sources of information existed and a community of users often shared ideas and prompted the advancement of the products. Office-based CBCT has advanced significantly since that time. It has often been described as the "gold standard" for imaging the oral and maxillofacial area and will become a part of the everyday life of most practices in the coming decades. PMID:18805227

  5. Characteristics of megavoltage cone-beam digital tomosynthesis

    SciTech Connect

    Descovich, M.; Morin, O.; Aubry, J. F.; Aubin, M.; Chen, J.; Bani-Hashemi, A; Pouliot, J.

    2008-04-15

    This article reports on the image characteristics of megavoltage cone-beam digital tomosynthesis (MVCB DT). MVCB DT is an in-room imaging technique, which enables the reconstruction of several two-dimensional slices from a set of projection images acquired over an arc of 20 deg. - 40 deg. The limited angular range reduces the acquisition time and the dose delivered to the patient, but affects the image quality of the reconstructed tomograms. Image characteristics (slice thickness, shape distortion, and contrast-to-noise ratio) are studied as a function of the angular range. Potential clinical applications include patient setup and the development of breath holding techniques for gated imaging.

  6. Auto calibration of a cone-beam-CT

    SciTech Connect

    Gross, Daniel; Heil, Ulrich; Schulze, Ralf; Schoemer, Elmar; Schwanecke, Ulrich

    2012-10-15

    Purpose: This paper introduces a novel autocalibration method for cone-beam-CTs (CBCT) or flat-panel CTs, assuming a perfect rotation. The method is based on ellipse-fitting. Autocalibration refers to accurate recovery of the geometric alignment of a CBCT device from projection images alone, without any manual measurements. Methods: The authors use test objects containing small arbitrarily positioned radio-opaque markers. No information regarding the relative positions of the markers is used. In practice, the authors use three to eight metal ball bearings (diameter of 1 mm), e.g., positioned roughly in a vertical line such that their projection image curves on the detector preferably form large ellipses over the circular orbit. From this ellipse-to-curve mapping and also from its inversion the authors derive an explicit formula. Nonlinear optimization based on this mapping enables them to determine the six relevant parameters of the system up to the device rotation angle, which is sufficient to define the geometry of a CBCT-machine assuming a perfect rotational movement. These parameters also include out-of-plane rotations. The authors evaluate their method by simulation based on data used in two similar approaches [L. Smekal, M. Kachelriess, S. E, and K. Wa, 'Geometric misalignment and calibration in cone-beam tomography,' Med. Phys. 31(12), 3242-3266 (2004); K. Yang, A. L. C. Kwan, D. F. Miller, and J. M. Boone, 'A geometric calibration method for cone beam CT systems,' Med. Phys. 33(6), 1695-1706 (2006)]. This allows a direct comparison of accuracy. Furthermore, the authors present real-world 3D reconstructions of a dry human spine segment and an electronic device. The reconstructions were computed from projections taken with a commercial dental CBCT device having two different focus-to-detector distances that were both calibrated with their method. The authors compare their reconstruction with a reconstruction computed by the manufacturer of the CBCT device to

  7. Algorithm for hyperfast cone-beam spiral backprojection.

    PubMed

    Steckmann, Sven; Knaup, Michael; Kachelriess, Marc

    2010-06-01

    Cone-beam spiral backprojection is computationally highly demanding. At first sight, the backprojection requirements are similar to those of cone-beam backprojection from circular scans such as it is performed in the widely used Feldkamp algorithm. However, there is an additional complication: the illumination of each voxel, i.e. the range of angles the voxel is seen by the X-ray cone is a complex function of the voxel position. The weight function has no analytically closed form and must be numerically determined. Storage of the weights is prohibitive since the amount of memory required equals the number of voxels per spiral rotation times the number of projections a voxel receives contributions and therefore is in the order of 10(9) to 10(11) floating point values for typical spiral scans. We propose a new algorithm that combines the spiral symmetry with the ability of today's 64 bit CPUs to store large amounts of precomputed weights. Using the spiral symmetry in this way allows to exploit data-level parallelism and thereby to achieve a very high level of vectorization. An additional postprocessing step rotates these slices back to normal images. Our new backprojection algorithm achieves up to 24.6 Giga voxel updates per second (GUPS) on our systems that are equipped with two standard Intel X5570 quad core CPUs (Intel Xeon 5500 platform, 2.93 GHz, Intel Corporation). This equals the reconstruction of 410 images per second assuming each slice consists of 512 x 512 pixels, receiving contributions from 512 projections. PMID:19765852

  8. A geometric calibration method for cone beam CT systems

    SciTech Connect

    Yang, Kai; Kwan, Alexander L. C.; Miller, DeWitt F.; Boone, John M.

    2006-06-15

    Cone beam CT systems are being deployed in large numbers for small animal imaging, dental imaging, and other specialty applications. A new high-precision method for cone beam CT system calibration is presented in this paper. It uses multiple projection images acquired from rotating point-like objects (metal ball bearings) and the angle information generated from the rotating gantry system is also used. It is assumed that the whole system has a mechanically stable rotation center and that the detector does not have severe out-of-plane rotation (<2 deg.). Simple geometrical relationships between the orbital paths of individual BBs and five system parameters were derived. Computer simulations were employed to validate the accuracy of this method in the presence of noise. Equal or higher accuracy was achieved compared with previous methods. This method was implemented for the geometrical calibration of both a micro CT scanner and a breast CT scanner. The reconstructed tomographic images demonstrated that the proposed method is robust and easy to implement with high precision.

  9. Development of a 3D CT scanner using cone beam

    NASA Astrophysics Data System (ADS)

    Endo, Masahiro; Kamagata, Nozomu; Sato, Kazumasa; Hattori, Yuichi; Kobayashi, Shigeo; Mizuno, Shinichi; Jimbo, Masao; Kusakabe, Masahiro

    1995-05-01

    In order to acquire 3D data of high contrast objects such as bone, lung and vessels enhanced by contrast media for use in 3D image processing, we have developed a 3D CT-scanner using cone beam x ray. The 3D CT-scanner consists of a gantry and a patient couch. The gantry consists of an x-ray tube designed for cone beam CT and a large area two-dimensional detector mounted on a single frame and rotated around an object in 12 seconds. The large area detector consists of a fluorescent plate and a charge coupled device video camera. The size of detection area was 600 mm X 450 mm capable of covering the total chest. While an x-ray tube was rotated around an object, pulsed x ray was exposed 30 times a second and 360 projected images were collected in a 12 second scan. A 256 X 256 X 256 matrix image (1.25 mm X 1.25 mm X 1.25 mm voxel) was reconstructed by a high-speed reconstruction engine. Reconstruction time was approximately 6 minutes. Cylindrical water phantoms, anesthetized rabbits with or without contrast media, and a Japanese macaque were scanned with the 3D CT-scanner. The results seem promising because they show high spatial resolution in three directions, though there existed several point to be improved. Possible improvements are discussed.

  10. Evaluation of lens absorbed dose with Cone Beam IGRT procedures.

    PubMed

    Palomo, R; Pujades, M C; Gimeno-Olmos, J; Carmona, V; Lliso, F; Candela-Juan, C; Vijande, J; Ballester, F; Perez-Calatayud, J

    2015-12-01

    The purpose of this work is to evaluate the absorbed dose to the eye lenses due to the cone beam computed tomography (CBCT) system used to accurately position the patient during head-and-neck image guided procedures. The on-board imaging (OBI) systems (v.1.5) of Clinac iX and TrueBeam (Varian) accelerators were used to evaluate the imparted dose to the eye lenses and some additional points of the head. All CBCT scans were acquired with the Standard-Dose Head protocol from Varian. Doses were measured using thermoluminescence dosimeters (TLDs) placed in an anthropomorphic phantom. TLDs were calibrated at the beam quality used to reduce their energy dependence. Average dose to the lens due to the OBI systems of the Clinac iX and the TrueBeam were 0.71  ±  0.07 mGy/CBCT and 0.70  ±  0.08 mGy/CBCT, respectively. The extra absorbed dose received by the eye lenses due to one CBCT acquisition with the studied protocol is far below the 500 mGy threshold established by ICRP for cataract formation (ICRP 2011 Statement on Tissue Reactions). However, the incremental effect of several CBCT acquisitions during the whole treatment should be taken into account. PMID:26457404

  11. Clinical utility of dental cone-beam computed tomography: current perspectives

    PubMed Central

    Jaju, Prashant P; Jaju, Sushma P

    2014-01-01

    Panoramic radiography and computed tomography were the pillars of maxillofacial diagnosis. With the advent of cone-beam computed tomography, dental practice has seen a paradigm shift. This review article highlights the potential applications of cone-beam computed tomography in the fields of dental implantology and forensic dentistry, and its limitations in maxillofacial diagnosis. PMID:24729729

  12. Applications of cone beam computed tomography for a prosthodontist.

    PubMed

    John, George Puthenpurayil; Joy, Tatu Elenjickal; Mathew, Justin; Kumar, Vinod R B

    2016-01-01

    Cone beam computed tomography (CBCT) is a medical imaging technique of X-ray computed tomography where the X-rays are divergent, forming a cone. CBCT systems have been designed for imaging hard tissues of the maxillofacial region. The increasing availability of this technology provides the dental clinician with an imaging modality capable of providing a three-dimensional representation of the maxillofacial skeleton with minimal distortion. This article is intended to elaborate and enunciate on the various applications and benefits of CBCT, in the realm of maxillofacial prosthodontics, over and beyond its obvious benefits in the rehabilitation of patients with implants. With the onus of meticulous reconstruction of near ideal occlusion resting on the prosthodontist, CBCT provides a unique imaging option, which can be a boon in various aspects of prosthodontic practice - from imaging of the temporomandibular joint for accurate movement simulation, to template assisted maxillofacial reconstruction or even over denture therapy. CBCT could play a crucial role in lessening the burden of a hectic prosthodontic routine for the clinician and critically contribute to accurate and effective treatment for the patient. Apart from the authors' clinical experiences shared here, a web-based search for relevant articles in this specific area of interest was also conducted. The selected articles were critically reviewed and the data acquired were systematically compiled. PMID:27134420

  13. Exact fan-beam and 4{pi}-acquisition cone-beam SPECT algorithms with uniform attenuation correction

    SciTech Connect

    Tang Qiulin; Zeng, Gengsheng L.; Wu Jiansheng; Gullberg, Grant T.

    2005-11-15

    This paper presents analytical fan-beam and cone-beam reconstruction algorithms that compensate for uniform attenuation in single photon emission computed tomography. First, a fan-beam algorithm is developed by obtaining a relationship between the two-dimensional (2D) Fourier transform of parallel-beam projections and fan-beam projections. Using this relationship, 2D Fourier transforms of equivalent parallel-beam projection data are obtained from the fan-beam projection data. Then a quasioptimal analytical reconstruction algorithm for uniformly attenuated Radon data, developed by Metz and Pan, is used to reconstruct the image. A cone-beam algorithm is developed by extending the fan-beam algorithm to 4{pi} solid angle geometry. The cone-beam algorithm is also an exact algorithm.

  14. Diagnostic Applications of Cone-Beam CT for Periodontal Diseases

    PubMed Central

    AlJehani, Yousef A.

    2014-01-01

    Objectives. This paper aims to review the diagnostic application of cone beam computed tomography (CBCT) in the field of periodontology. Data. Original articles that reported on the use of CBCT for periodontal disease diagnosis were included. Sources. MEDLINE (1990 to January 2014), PubMed (using medical subject headings), and Google Scholar were searched using the following terms in different combinations: “CBCT,” “volumetric CT,” “periodontal disease ,” and “periodontitis.” This was supplemented by hand-searching in peer-reviewed journals and cross-referenced with the articles accessed. Conclusions. Bony defects, caters, and furcation involvements seem to be better depicted on CBCT, whereas bone quality and periodontal ligament space scored better on conventional intraoral radiography. CBCT does not offer a significant advantage over conventional radiography for assessing the periodontal bone levels. PMID:24803932

  15. Fossa navicularis magna detection on cone-beam computed tomography.

    PubMed

    Syed, Ali Z; Mupparapu, Mel

    2016-03-01

    Herein, we report and discuss the detection of fossa navicularis magna, a close radiographic anatomic variant of canalis basilaris medianus of the basiocciput, as an incidental finding in cone-beam computed tomography (CBCT) imaging. The CBCT data of the patients in question were referred for the evaluation of implant sites and to rule out pathology in the maxilla and mandible. CBCT analysis showed osseous, notch-like defects on the inferior aspect of the clivus in all four cases. The appearance of fossa navicularis magna varied among the cases. In some, it was completely within the basiocciput and mimicked a small rounded, corticated, lytic defect, whereas it appeared as a notch in others. Fossa navicularis magna is an anatomical variant that occurs on the inferior aspect of the clivus. The pertinent literature on the anatomical variations occurring in this region was reviewed. PMID:27051639

  16. Cone beam CT: a current overview of devices

    PubMed Central

    Nemtoi, A; Czink, C; Haba, D; Gahleitner, A

    2013-01-01

    The purpose of this study was to review and compare the properties of all the available cone beam CT (CBCT) devices offered on the market, while focusing especially on Europe. In this study, we included all the different commonly used CBCT devices currently available on the European market. Information about the properties of each device was obtained from the manufacturers’ official available data, which was later confirmed by their representatives in cases where it was necessary. The main features of a total of 47 CBCT devices that are currently marketed by 20 companies were presented, compared and discussed in this study. All these CBCT devices differ in specific properties according to the companies that produce them. The summarized technical data from a large number of CBCT devices currently on the market offer a wide range of imaging possibilities in the oral and maxillofacial region. PMID:23818529

  17. Fossa navicularis magna detection on cone-beam computed tomography

    PubMed Central

    Mupparapu, Mel

    2016-01-01

    Herein, we report and discuss the detection of fossa navicularis magna, a close radiographic anatomic variant of canalis basilaris medianus of the basiocciput, as an incidental finding in cone-beam computed tomography (CBCT) imaging. The CBCT data of the patients in question were referred for the evaluation of implant sites and to rule out pathology in the maxilla and mandible. CBCT analysis showed osseous, notch-like defects on the inferior aspect of the clivus in all four cases. The appearance of fossa navicularis magna varied among the cases. In some, it was completely within the basiocciput and mimicked a small rounded, corticated, lytic defect, whereas it appeared as a notch in others. Fossa navicularis magna is an anatomical variant that occurs on the inferior aspect of the clivus. The pertinent literature on the anatomical variations occurring in this region was reviewed. PMID:27051639

  18. Reduction of beam hardening artifacts in cone-beam CT imaging via SMART-RECON algorithm

    NASA Astrophysics Data System (ADS)

    Li, Yinsheng; Garrett, John; Chen, Guang-Hong

    2016-03-01

    When an automatic exposure control is introduced in C-arm cone beam CT data acquisition, the spectral inconsistencies between acquired projection data are exacerbated. As a result, conventional water/bone correction schemes are not as effective as in conventional diagnostic x-ray CT acquisitions with a fixed tube potential. In this paper, a new method was proposed to reconstruct several images with different degrees of spectral consistency and thus different levels of beam hardening artifacts. The new method relies neither on prior knowledge of the x-ray beam spectrum nor on prior compositional information of the imaging object. Numerical simulations were used to validate the algorithm.

  19. Dual resolution cone beam breast CT: A feasibility study

    PubMed Central

    Chen, Lingyun; Shen, Youtao; Lai, Chao-Jen; Han, Tao; Zhong, Yuncheng; Ge, Shuaiping; Liu, Xinming; Wang, Tianpeng; Yang, Wei T.; Whitman, Gary J.; Shaw, Chris C.

    2009-01-01

    Purpose: In this study, the authors investigated the feasibility of a dual resolution volume-of-interest (VOI) cone beam breast CT technique and compared two implementation approaches in terms of dose saving and scatter reduction. Methods: With this technique, a lead VOI mask with an opening is inserted between the x-ray source and the breast to deliver x-ray exposure to the VOI while blocking x rays outside the VOI. A CCD detector is used to collect the high resolution projection data of the VOI. Low resolution cone beam CT (CBCT) images of the entire breast, acquired with a flat panel (FP) detector, were used to calculate the projection data outside the VOI with the ray-tracing reprojection method. The Feldkamp–Davis–Kress filtered backprojection algorithm was used to reconstruct the dual resolution 3D images. Breast phantoms with 180 μm and smaller microcalcifications (MCs) were imaged with both FP and FP-CCD dual resolution CBCT systems, respectively. Two approaches of implementing the dual resolution technique, breast-centered approach and VOI-centered approach, were investigated and evaluated for dose saving and scatter reduction with Monte Carlo simulation using a GEANT4 package. Results: The results showed that the breast-centered approach saved more breast absorbed dose than did VOI-centered approach with similar scatter reduction. The MCs in fatty breast phantom, which were invisible with FP CBCT scan, became visible with the FP-CCD dual resolution CBCT scan. Conclusions: These results indicate potential improvement of the image quality inside the VOI with reduced breast dose both inside and outside the VOI. PMID:19810473

  20. Beam characteristics and radiation output of a kilovoltage cone-beam CT

    NASA Astrophysics Data System (ADS)

    Ding, George X.; Coffey, Charles W.

    2010-09-01

    This study presents beam characteristics of five recently available x-ray beams produced by an on-board imager (OBI 1.4) for acquiring kilovoltage cone-beam computed tomography (kV-CBCT) and investigates suitable methods for the beam radiation output determination resulting from an image acquisition. Both are essential for commissioning an x-ray beam in a radiotherapy treatment planning system. The BEAM/DOSXYZnrc Monte Carlo codes were used in the investigation. The simulated beam data were benchmarked against measurements. Three different commercially available plastic phantom materials are investigated as liquid water substitutes in the beam radiation output determination. Ionization chambers are used for the measurements. Five kV-CBCT beam characteristics including photon fluence, average beam energy and photon spectra are generated from Monte Carlo simulations. The Monte Carlo calculated dose profiles are validated by measurements. The fluence of kV-CBCT beams is strongly dependent on the geometry of added filters as well as X and Y beam collimations. The potential errors of determining the beam output of a kV-CBCT beam in Solid Water and PMMA phantoms may approach 8% and 20%, respectively, for use in a conventional treatment planning system, whereas using the Plastic Water low-energy range (PW-LR) phantom results in errors within 2%. The Monte Carlo simulation is essential in providing the parameters of an x-ray beam which are needed for the commissioning of a kV-CBCT beam in a radiotherapy treatment planning system. The PW-LR phantom is a suitable liquid water substitute in the beam output determination resulting from a kV-CBCT acquisition.

  1. Filtered region of interest cone-beam rotational angiography

    SciTech Connect

    Schafer, Sebastian; Noeel, Peter B.; Walczak, Alan M.; Hoffmann, Kenneth R.

    2010-02-15

    Purpose: Cone-beam rotational angiography (CBRA) is widely used in the modern clinical settings. In a number of procedures, the area of interest is often considerably smaller than the field of view (FOV) of the detector, subjecting the patient to potentially unnecessary x-ray dose. The authors therefore propose a filter-based method to reduce the dose in the regions of low interest, while supplying high image quality in the region of interest (ROI). Methods: For such procedures, the authors propose a method of filtered region of interest (FROI)-CBRA. In the authors' approach, a gadolinium filter with a circular central opening is placed into the x-ray beam during image acquisition. The central region is imaged with high contrast, while peripheral regions are subjected to a substantial lower intensity and dose through beam filtering. The resulting images contain a high contrast/intensity ROI, as well as a low contrast/intensity peripheral region, and a transition region in between. To equalize the two regions' intensities, the first projection of the acquisition is performed with and without the filter in place. The equalization relationship, based on Beer's law, is established through linear regression using corresponding filtered and nonfiltered data. The transition region is equalized based on radial profiles. Results: Evaluations in 2D and 3D show no visible difference between conventional FROI-CBRA projection images and reconstructions in the ROI. CNR evaluations show similar image quality in the ROI, with a reduced CNR in the reconstructed peripheral region. In all filtered projection images, the scatter fraction inside the ROI was reduced. Theoretical and experimental dose evaluations show a considerable dose reduction; using a ROI half the original FOV reduces the dose by 60% for the filter thickness of 1.29 mm. Conclusions: These results indicate the potential of FROI-CBRA to reduce the dose to the patient while supplying the physician with the desired

  2. Upright cone beam CT imaging using the onboard imager

    SciTech Connect

    Fave, Xenia Martin, Rachael; Yang, Jinzhong; Balter, Peter; Court, Laurence; Carvalho, Luis; Pan, Tinsu

    2014-06-15

    Purpose: Many patients could benefit from being treated in an upright position. The objectives of this study were to determine whether cone beam computed tomography (CBCT) could be used to acquire upright images for treatment planning and to demonstrate whether reconstruction of upright images maintained accurate geometry and Hounsfield units (HUs). Methods: A TrueBeam linac was programmed in developer mode to take upright CBCT images. The gantry head was positioned at 0°, and the couch was rotated to 270°. The x-ray source and detector arms were extended to their lateral positions. The x-ray source and gantry remained stationary as fluoroscopic projections were taken and the couch was rotated from 270° to 90°. The x-ray tube current was normalized to deposit the same dose (measured using a calibrated Farmer ion chamber) as that received during a clinical helical CT scan to the center of a cylindrical, polyethylene phantom. To extend the field of view, two couch rotation scans were taken with the detector offset 15 cm superiorly and then 15 cm inferiorly. The images from these two scans were stitched together before reconstruction. Upright reconstructions were compared to reconstructions from simulation CT scans of the same phantoms. Two methods were investigated for correcting the HUs, including direct calibration and mapping the values from a simulation CT. Results: Overall geometry, spatial linearity, and high contrast resolution were maintained in upright reconstructions. Some artifacts were created and HU accuracy was compromised; however, these limitations could be removed by mapping the HUs from a simulation CT to the upright reconstruction for treatment planning. Conclusions: The feasibility of using the TrueBeam linac to take upright CBCT images was demonstrated. This technique is straightforward to implement and could be of enormous benefit to patients with thoracic tumors or those who find a supine position difficult to endure.

  3. TH-A-18C-06: A Scatter Elimination Scheme for Cone Beam CT Using An Oscillating Narrow Beam

    SciTech Connect

    Yan, H; Folkerts, M; Jia, X; Jiang, S; Xu, Y

    2014-06-15

    Purpose: While cone beam CT (CBCT) has been widely used in image guided radiation therapy, its low image quality, primarily caused by scattered x-rays, hinders advanced clinical applications, e.g., CBCT based on-line adaptive re-planning. We propose in this abstract a new scheme called oscillating narrow beam CBCT (ONB-CBCT) to eliminate scatter signals. Methods: ONB-CBCT consists of two major components. 1) Oscillating narrow beam (ONB) scan and 2) partitioned flat panel containing multiple individual detector strips and their own readouts. Both the beam oscillation and detector partition are along the superior-inferior (SI) direction. During data acquisition, at a given projection, the narrow beam sweep through the detector region, and different portions of the detector acquires projection data in synchrony with the narrow beam. ONB can be generated by a rotating slit collimator design with conventional tube with single focal spot, or by directly using a new source with multiple focal spots. A proof-of-principle study via Monte Carlo simulation is conducted to demonstrate the feasibility of ONB-CBCT. Results: As the beam becomes narrower, more and more scatter signals are eliminated. For the case with a bowtie filter and using 15 ONBs, the maximum and the average intensity error due to scatter are below 20 and 10 HU, respectively. Conclusion: ONB yields a narrowed exposure field at each snapshot and hence an inherently negligible scatter effect. Meanwhile, the individualized detector units guarantee high frame rate detection and hence a same large volume coverage as that in conventional CBCT. In summary, ONB-CBCT is a promising design to achieve high-quality CBCT imaging. This study is supported in part by NIH (1R01CA154747-01)

  4. A phenomenological kV beam model for cone-beam imaging

    NASA Astrophysics Data System (ADS)

    Bhagwat, Mandar S.; Blessing, Manuel; Lyatskaya, Yulia; Zygmanski, Piotr

    2010-10-01

    A phenomenological kV beam model was developed to address attenuation and scatter in radiographic images for the purpose of cone-beam imaging. Characterization of a kV beam in terms of the minimal number of parameters and calculation of attenuation and scatter in radiographs of scanned objects are the main applications of this model. Model parameters are derived from radiographs of homogeneous solid water phantoms for various depths and field sizes. The response of the cone-beam detector to kV beams is factorized into different contributions such as output factor, tissue-air ratio and off-axis ratio, with each contribution having an analytical representation. The formulas which are used to characterize the beam model in uniform phantoms are then extended to arbitrary objects using the concept of the water-equivalent pathlength. A weighted sum of three Gaussians in each direction models the dose deposition kernel. Detector response arising from the first Gaussian term can be interpreted as the primary signal while the second and third Gaussians constitute short- and long-range scatter. The model is then applied to predict the primary and scatter signals for arbitrary objects. A technique of scatter removal from the measured radiographs is investigated. The model accurately predicts detector response of varying-thickness phantoms such as multi-step and cylindrical phantoms. The scatter contributes over 90% to the total signal for 20 cm thick phantoms. The calculated scatter-to-primary ratio as a function of spatial coordinates agrees with Monte Carlo studies reported in the literature. Water-equivalent thickness related to primary and scatter contributions calculated from an analysis of radiographs results in an improved calibration technique suitable for CB-CT reconstruction. The kV beam model and the associated theoretical formulations can be utilized to characterize any kV beam line; however, for the specific study the OBI™ system (Varian) was used to obtain

  5. Cone-beam computed tomography findings of impacted upper canines

    PubMed Central

    Bastos, Luana Costa; Oliveira-Santos, Christiano; da Silva, Silvio José Albergaria; Neves, Frederico Sampaio; Campos, Paulo Sérgio Flores

    2014-01-01

    Purpose To describe the features of impacted upper canines and their relationship with adjacent structures through three-dimensional cone-beam computed tomography (CBCT) images. Materials and Methods Using the CBCT scans of 79 upper impacted canines, we evaluated the following parameters: gender, unilateral/bilateral occurrence, location, presence and degree of root resorption of adjacent teeth (mild, moderate, or severe), root dilaceration, dental follicle width, and presence of other associated local conditions. Results Most of the impacted canines were observed in females (56 cases), unilaterally (51 cases), and at a palatine location (53 cases). Root resorption in adjacent teeth and root dilaceration were observed in 55 and 47 impacted canines, respectively. In most of the cases, the width of the dental follicle of the canine was normal; it was abnormally wide in 20 cases. A statistically significant association was observed for all variables, except for root dilaceration (p=0.115) and the side of impaction (p=0.260). Conclusion Root resorption of adjacent teeth was present in most cases of canine impaction, mostly affecting adjacent lateral incisors to a mild degree. A wide dental follicle of impacted canines was not associated with a higher incidence of external root resorption of adjacent teeth. PMID:25473636

  6. FFT and cone-beam CT reconstruction on graphics hardware

    NASA Astrophysics Data System (ADS)

    Després, Philippe; Sun, Mingshan; Hasegawa, Bruce H.; Prevrhal, Sven

    2007-03-01

    Graphics processing units (GPUs) are increasingly used for general purpose calculations. Their pipelined architecture can be exploited to accelerate various parallelizable algorithms. Medical imaging applications are inherently well suited to benefit from the development of GPU-based computational platforms. We evaluate in this work the potential of GPUs to improve the execution speed of two common medical imaging tasks, namely Fourier transforms and tomographic reconstructions. A two-dimensional fast Fourier transform (FFT) algorithm was GPU-implemented and compared, in terms of execution speed, to two popular CPU-based FFT routines. Similarly, the Feldkamp, David and Kress (FDK) algorithm for cone-beam tomographic reconstruction was implemented on the GPU and its performance compared to a CPU version. Different reconstruction strategies were employed to assess the performance of various GPU memory layouts. For the specific hardware used, GPU implementations of the FFT were up to 20 times faster than their CPU counterparts, but slower than highly optimized CPU versions of the algorithm. Tomographic reconstructions were faster on the GPU by a factor up to 30, allowing 256 3 voxel reconstructions of 256 projections in about 20 seconds. Overall, GPUs are an attractive alternative to other imaging-dedicated computing hardware like application-specific integrated circuits (ASICs) and field programmable gate arrays (FPGAs) in terms of cost, simplicity and versatility. With the development of simpler language extensions and programming interfaces, GPUs are likely to become essential tools in medical imaging.

  7. Can Dental Cone Beam Computed Tomography Assess Bone Mineral Density?

    PubMed Central

    2014-01-01

    Mineral density distribution of bone tissue is altered by active bone modeling and remodeling due to bone complications including bone disease and implantation surgery. Clinical cone beam computed tomography (CBCT) has been examined whether it can assess oral bone mineral density (BMD) in patient. It has been indicated that CBCT has disadvantages of higher noise and lower contrast than conventional medical computed tomography (CT) systems. On the other hand, it has advantages of a relatively lower cost and radiation dose but higher spatial resolution. However, the reliability of CBCT based mineral density measurement has not yet been fully validated. Thus, the objectives of this review are to discuss 1) why assessment of BMD distribution is important and 2) whether the clinical CBCT can be used as a potential tool to measure the BMD. Brief descriptions of image artefacts associated with assessment of gray value, which has been used to account for mineral density, in CBCT images are provided. Techniques to correct local and conversion errors in obtaining the gray values in CBCT images are also introduced. This review can be used as a quick reference for users who may encounter these errors during analysis of CBCT images. PMID:25006568

  8. GPU-based cone-beam reconstruction using wavelet denoising

    NASA Astrophysics Data System (ADS)

    Jin, Kyungchan; Park, Jungbyung; Park, Jongchul

    2012-03-01

    The scattering noise artifact resulted in low-dose projection in repetitive cone-beam CT (CBCT) scans decreases the image quality and lessens the accuracy of the diagnosis. To improve the image quality of low-dose CT imaging, the statistical filtering is more effective in noise reduction. However, image filtering and enhancement during the entire reconstruction process exactly may be challenging due to high performance computing. The general reconstruction algorithm for CBCT data is the filtered back-projection, which for a volume of 512×512×512 takes up to a few minutes on a standard system. To speed up reconstruction, massively parallel architecture of current graphical processing unit (GPU) is a platform suitable for acceleration of mathematical calculation. In this paper, we focus on accelerating wavelet denoising and Feldkamp-Davis-Kress (FDK) back-projection using parallel processing on GPU, utilize compute unified device architecture (CUDA) platform and implement CBCT reconstruction based on CUDA technique. Finally, we evaluate our implementation on clinical tooth data sets. Resulting implementation of wavelet denoising is able to process a 1024×1024 image within 2 ms, except data loading process, and our GPU-based CBCT implementation reconstructs a 512×512×512 volume from 400 projection data in less than 1 minute.

  9. Radiological protection in computed tomography and cone beam computed tomography.

    PubMed

    Rehani, M M

    2015-06-01

    The International Commission on Radiological Protection (ICRP) has sustained interest in radiological protection in computed tomography (CT), and ICRP Publications 87 and 102 focused on the management of patient doses in CT and multi-detector CT (MDCT) respectively. ICRP forecasted and 'sounded the alarm' on increasing patient doses in CT, and recommended actions for manufacturers and users. One of the approaches was that safety is best achieved when it is built into the machine, rather than left as a matter of choice for users. In view of upcoming challenges posed by newer systems that use cone beam geometry for CT (CBCT), and their widened usage, often by untrained users, a new ICRP task group has been working on radiological protection issues in CBCT. Some of the issues identified by the task group are: lack of standardisation of dosimetry in CBCT; the false belief within the medical and dental community that CBCT is a 'light', low-dose CT whereas mobile CBCT units and newer applications, particularly C-arm CT in interventional procedures, involve higher doses; lack of training in radiological protection among clinical users; and lack of dose information and tracking in many applications. This paper provides a summary of approaches used in CT and MDCT, and preliminary information regarding work just published for radiological protection in CBCT. PMID:25816279

  10. Cone Beam Computed Tomographic Assessment of Bifid Mandibular Condyle

    PubMed Central

    Khojastepour, Leila; Kolahi, Shirin; Panahi, Nazi

    2015-01-01

    Objectives: Differential diagnosis of bifid mandibular condyle (BMC) is important, since it may play a role in temporomandibular joint (TMJ) dysfunctions and joint symptoms. In addition, radiographic appearance of BMC may mimic tumors and/or fractures. The aim of this study was to evaluate the prevalence and orientation of BMC based on cone beam computed tomography (CBCT) scans. Materials and Methods: This cross-sectional study was performed on CBCT scans of paranasal sinuses of 425 patients. In a designated NNT station, all CBCT scans were evaluated in the axial, coronal and sagittal planes to find the frequency of BMC. The condylar head horizontal angulations were also determined in the transverse plane. T-test was used to compare the frequency of BMC between the left and right sides and between males and females. Results: Totally, 309 patients with acceptable visibility of condyles on CBCT scans were entered in the study consisting of 170 (55%) females and 139 (45%) males with a mean age of 39.43±9.7 years. The BMC was detected in 14 cases (4.53%). Differences between males and females, sides and horizontal angulations of condyle of normal and BMC cases were not significant. Conclusion: The prevalence of BMC in the studied population was 4.53%. No significant difference was observed between males and females, sides or horizontal angulations of the involved and uninvolved condyles.

  11. Characterization of scatter radiation in cone beam CT mammography

    NASA Astrophysics Data System (ADS)

    Liu, Bob; Glick, Stephen J.; Groiselle, Corinne

    2005-04-01

    Cone beam CT mammography (CBCTM) is an emerging breast imaging technology and is currently under intensive investigation [1-3]. One of the major challenges in CBCTM is to understand the characteristics of scatter radiation and to find ways to reduce or correct its degrading effects. Since the breast shape, geometry and image formation process are significantly different from conventional mammography, all system components and parameters such as target/filter combination, kVp range, source to image distance, detector design etc. should be examined and optimized. In optimizing CBCTM systems, it is important to have knowledge of how different imaging parameters affect the recorded scatter within the image. In this study, a GEANT4 based Monte Carlo simulation package (GATE) was used to investigate the scatter magnitude and its" distribution in CBCTM. The influences of different air gaps, kVp settings, breast sizes and breast composition on the scatter primary ratio (SPR) and scatter profiles were examined. In general, the scatter to primary ratio (SPR) is strongly dependent on the breast size and air gap, and is only moderately dependent on the kVp setting and breast composition. These results may be used for optimization of CBCTM systems, as well as for developing scatter correction methods.

  12. Streak artifact reduction in cardiac cone beam CT

    NASA Astrophysics Data System (ADS)

    Shechter, Gilad; Naveh, Galit; Lessick, Jonathan; Altman, Ami

    2005-04-01

    Cone beam reconstructed cardiac CT images suffer from characteristic streak artifacts that affect the quality of coronary artery imaging. These artifacts arise from inhomogeneous distribution of noise. While in non-tagged reconstruction inhomogeneity of noise distribution is mainly due to anisotropy of the attenuation of the scanned object (e.g. shoulders), in cardiac imaging it is largely influenced by the non-uniform distribution of the acquired data used for reconstructing the heart at a given phase. We use a cardiac adaptive filter to reduce these streaks. In difference to previous methods of adaptive filtering that locally smooth data points on the basis of their attenuation values, our filter is applied as a function of the noise distribution of the data as it is used in the phase selective reconstruction. We have reconstructed trans-axial images without adaptive filtering, with a regular adaptive filter and with the cardiac adaptive filter. With the cardiac adaptive filter significant reduction of streaks is achieved, and thus image quality is improved. The coronary vessel is much more pronounced in the cardiac adaptive filtered images, in slab MIP the main coronary artery branches are more visible, and non-calcified plaque is better differentiated from vessel wall. This improvement is accomplished without altering significantly the border definition of calcified plaques.

  13. Effective dose span of ten different cone beam CT devices

    PubMed Central

    Rottke, D; Patzelt, S; Poxleitner, P; Schulze, D

    2013-01-01

    Objectives: Evaluation and reduction of dose are important issues. Since cone beam CT (CBCT) has been established now not just in dentistry, the number of acquired examinations continues to rise. Unfortunately, it is very difficult to compare the doses of available devices on the market owing to different exposition parameters, volumes and geometries. The aim of this study was to evaluate the spans of effective doses (EDs) of ten different CBCT devices. Methods: 48 thermoluminescent dosemeters were placed in 24 sites in a RANDO® head phantom. Protocols with lowest exposition parameters and protocols with highest exposition parameters were performed for each of the ten devices. The ED was calculated from the measured energy doses according to the International Commission on Radiological Protection 2007 recommendations for each protocol and device, and the statistical values were evaluated afterwards. Results: The calculation of the ED resulted in values between 17.2 µSv and 396 µSv for the ten devices. The mean values for protocols with lowest and highest exposition parameters were 31.6 µSv and 209 µSv, respectively. Conclusions: It was not the aim of this study to evaluate the image quality depending on different exposition parameters but to define the spans of EDs in which different CBCT devices work. There is a wide span of ED for different CBCT devices depending on the selected exposition parameters, required spatial resolution and many other factors. PMID:23584925

  14. Application of cone beam volumetric tomography in endodontics.

    PubMed

    Tyndall, D A; Kohltfarber, H

    2012-11-01

    In a 2008 article on cone beam volumetric tomography (CBVT) and dentoalveolar applications, Tyndall and Rathore wrote: "It is in the area of endodontic applications that the literature has proved most fruitful to date." This statement is even truer today than in 2008. A review of the literature has demonstrated that, in many cases, CBVT is more efficacious than traditional forms of 2-D imaging. Endodontic applications of CBVT include the diagnosis of periapical lesions due to pulpal inflammation, identification, and localization of internal and external resorption, the detection of vertical root fractures, the visualization of accessory canals, and elucidation of the causes of non-healing endodontically treated teeth. Prior to 2008, most published articles on CBVT applications in endodontics were either case reports or in vitro studies. Since that time more well designed clinically related scholarly activity has been published. This article attempts to survey the field of CBVT applications in endodontics and provide the readers with an overview of what has been found. The authors hope that this knowledge will form a foundation for appropriate clinical decision making with specific reference to selection criteria for the endodontic applications of CBVT. PMID:23487892

  15. Application of cone beam volumetric tomography in endodontics.

    PubMed

    Tyndall, Donald A; Kohltfarber, H

    2012-03-01

    In a 2008 article on cone beam volumetric tomography (CBVT) and dentoalveolar applications, Tyndall and Rathore wrote: 'It is in the area of endodontic applications that the literature has proved most fruitful to date.' This statement is even truer today than in 2008. A review of the literature has demonstrated that, in many cases, CBVT is more efficacious than traditional forms of 2-D imaging. Endodontic applications of CBVT include the diagnosis of periapical lesions due to pulpal inflammation, identification and localization of internal and external resorption, the detection of vertical root fractures, the visualization of accessory canals, and elucidation of the causes of non-healing endodontically treated teeth. Prior to 2008, most published articles on CBVT applications in endodontics were either case reports or in vitro studies. Since that time more well designed clinically related scholarly activity has been published. This article attempts to survey the field of CBVT applications in endodontics and provide the readers with an overview of what has been found. The authors hope that this knowledge will form a foundation for appropriate clinical decision making with specific reference to selection criteria for the endodontic applications of CBVT. PMID:22376099

  16. Dynamic Bowtie Filter for Cone-Beam/Multi-Slice CT

    PubMed Central

    Liu, Fenglin; Yang, Qingsong; Cong, Wenxiang; Wang, Ge

    2014-01-01

    A pre-patient attenuator (“bowtie filter” or “bowtie”) is used to modulate an incoming x-ray beam as a function of the angle of the x-ray with respect to a patient to balance the photon flux on a detector array. While the current dynamic bowtie design is focused on fan-beam geometry, in this study we propose a methodology for dynamic bowtie design in multi-slice/cone-beam geometry. The proposed 3D dynamic bowtie is an extension of the 2D prior art. The 3D bowtie consists of a highly attenuating bowtie (HB) filled in with heavy liquid and a weakly attenuating bowtie (WB) immersed in the liquid of the HB. The HB targets a balanced flux distribution on a detector array when no object is in the field of view (FOV). The WB compensates for an object in the FOV, and hence is a scaled-down version of the object. The WB is rotated and translated in synchrony with the source rotation and patient translation so that the overall flux balance is maintained on the detector array. First, the mathematical models of different scanning modes are established for an elliptical water phantom. Then, a numerical simulation study is performed to compare the performance of the scanning modes in the cases of the water phantom and a patient cross-section without any bowtie and with a dynamic bowtie. The dynamic bowtie can equalize the numbers of detected photons in the case of the water phantom. In practical cases, the dynamic bowtie can effectively reduce the dynamic range of detected signals inside the FOV. Furthermore, the WB can be individualized using a 3D printing technique as the gold standard. We have extended the dynamic bowtie concept from 2D to 3D by using highly attenuating liquid and moving a scale-reduced negative copy of an object being scanned. Our methodology can be applied to reduce radiation dose and facilitate photon-counting detection. PMID:25051067

  17. Cone beam computed tomography: Development of system characterization metrics and applications

    NASA Astrophysics Data System (ADS)

    Betancourt Benitez, Jose Ricardo

    Cone beam computed tomography has emerged as a promising medical imaging tool due to its short scanning time, large volume coverage and its isotropic spatial resolution in three dimensions among other characteristics. However, due to its inherent three-dimensionality, it is important to understand and characterize its physical characteristics to be able to improve its performance and extends its applications in medical imaging. One of the main components of a Cone beam computed tomography system is its flat panel detector. Its physical characteristics were evaluated in terms of spatial resolution, linearity, image lag, noise power spectrum and detective quantum efficiency. After evaluating the physical performance of the flat panel detector, metrics to evaluate the image quality of the system were developed and used to evaluate the systems image quality. Especially, the modulation transfer function and the noise power spectrum were characterized and evaluated for a PaxScan 4030CB FPD-based cone beam computed tomography system. Finally, novel applications using cone beam computed tomography images were suggested and evaluated for its practical application. For example, the characterization of breast density was evaluated and further studies were suggested that could impact the health system related to breast cancer. Another novel application was the utilization of cone beam computed tomography for orthopedic imaging. In this thesis, an initial assessment of its practical application was perform. Overall, three cone beam computed tomography systems were evaluated and utilized for different novel applications that would advance the field of medical imaging.

  18. Full data consistency conditions for cone-beam projections with sources on a plane.

    PubMed

    Clackdoyle, Rolf; Desbat, Laurent

    2013-12-01

    Cone-beam consistency conditions (also known as range conditions) are mathematical relationships between different cone-beam projections, and they therefore describe the redundancy or overlap of information between projections. These redundancies have often been exploited for applications in image reconstruction. In this work we describe new consistency conditions for cone-beam projections whose source positions lie on a plane. A further restriction is that the target object must not intersect this plane. The conditions require that moments of the cone-beam projections be polynomial functions of the source positions, with some additional constraints on the coefficients of the polynomials. A precise description of the consistency conditions is that the four parameters of the cone-beam projections (two for the detector, two for the source position) can be expressed with just three variables, using a certain formulation involving homogeneous polynomials. The main contribution of this work is our demonstration that these conditions are not only necessary, but also sufficient. Thus the consistency conditions completely characterize all redundancies, so no other independent conditions are possible and in this sense the conditions are full. The idea of the proof is to use the known consistency conditions for 3D parallel projections, and to then apply a 1996 theorem of Edholm and Danielsson that links parallel to cone-beam projections. The consistency conditions are illustrated with a simulation example. PMID:24240245

  19. Volumetric cone-beam CT system based on a 41x41 cm2 flat-panel imager

    NASA Astrophysics Data System (ADS)

    Jaffray, David A.; Siewerdsen, Jeffrey H.

    2001-06-01

    Cone-beam computed tomography (CBCT) based upon large-area flat-panel imager (FPI) technology is a flexible and adaptable technology that offers large field-of-view (FOV), high spatial resolution, and soft-tissue imaging. The imaging performance of FPI-based cone-beam CT has been evaluated on a computer-controlled bench-top system using an early prototype FPI with a small FOV (20.5 X 20.5 cm2). These investigations demonstrate the potential of this exciting technology. In this report, imaging performance is evaluated using a production grade large-area FPI (41 X 41 cm2) for which the manufacturer has achieved a significant reduction in additive noise. This reduction in additive noise results in a substantial improvement in detective quantum efficiency (DQE) at low exposures. The spatial resolution over the increased FOV of the cone-beam CT system is evaluated by imaging a fine steel wire placed at various locations within the volume of reconstruction. The measured modulation transfer function (MTF) of the system demonstrates spatial frequency pass beyond 1 mm-1 (10% modulation) with a slight degradation at points off the source plane. In addition to investigations of imaging performance, progress has also been made in the integration of this technology with a medical linear accelerator for on-line image-guided radiation therapy. Unlike the bench-top system, this implementation must contend with significant geometric non-idealities caused by gravity-induced flex of the x-ray tube and FPI support assemblies. A method of characterizing and correcting these non-idealities has been developed. Images of an anthropomorphic head phantom qualitatively demonstrate the excellent spatial resolution and large FOV achievable with the cone-beam approach in the clinical implementation.

  20. Assessment of liver ablation using cone beam computed tomography

    PubMed Central

    Abdel-Rehim, Mohamed; Ronot, Maxime; Sibert, Annie; Vilgrain, Valérie

    2015-01-01

    AIM: To investigate the feasibility and accuracy of cone beam computed tomography (CBCT) in assessing the ablation zone after liver tumor ablation. METHODS: Twenty-three patients (17 men and 6 women, range: 45-85 years old, mean age 65 years) with malignant liver tumors underwent ultrasound-guided percutaneous tumor ablation [radiofrequency (n = 14), microwave (n = 9)] followed by intravenous contrast-enhanced CBCT. Baseline multidetector computed tomography (MDCT) and peri-procedural CBCT images were compared. CBCT image quality was assessed as poor, good, or excellent. Image fusion was performed to assess tumor coverage, and quality of fusion was rated as bad, good, or excellent. Ablation zone volumes on peri-procedural CBCT and post-procedural MDCT were compared using the non-parametric paired Wilcoxon t-test. RESULTS: Rate of primary ablation effectiveness was 100%. There were no complications related to ablation. Local tumor recurrence and new liver tumors were found 3 mo after initial treatment in one patient (4%). The ablation zone was identified in 21/23 (91.3%) patients on CBCT. The fusion of baseline MDCT and peri-procedural CBCT images was feasible in all patients and showed satisfactory tumor coverage (at least 5-mm margin). CBCT image quality was poor, good, and excellent in 2 (9%), 8 (35%), and 13 (56%), patients respectively. Registration quality between peri-procedural CBCT and post-procedural MDCT images was good to excellent in 17/23 (74%) patients. The median ablation volume on peri-procedural CBCT and post-procedural MDCT was 30 cm3 (range: 4-95 cm3) and 30 cm3 (range: 4-124 cm3), respectively (P-value > 0.2). There was a good correlation (r = 0.79) between the volumes of the two techniques. CONCLUSION: Contrast-enhanced CBCT after tumor ablation of the liver allows early assessment of the ablation zone. PMID:25593467

  1. Task-driven imaging in cone-beam computed tomography

    NASA Astrophysics Data System (ADS)

    Gang, G. J.; Stayman, J. W.; Ouadah, S.; Ehtiati, T.; Siewerdsen, J. H.

    2015-03-01

    Purpose: Conventional workflow in interventional imaging often ignores a wealth of prior information of the patient anatomy and the imaging task. This work introduces a task-driven imaging framework that utilizes such information to prospectively design acquisition and reconstruction techniques for cone-beam CT (CBCT) in a manner that maximizes task-based performance in subsequent imaging procedures. Methods: The framework is employed in jointly optimizing tube current modulation, orbital tilt, and reconstruction parameters in filtered back-projection reconstruction for interventional imaging. Theoretical predictors of noise and resolution relates acquisition and reconstruction parameters to task-based detectability. Given a patient-specific prior image and specification of the imaging task, an optimization algorithm prospectively identifies the combination of imaging parameters that maximizes task-based detectability. Initial investigations were performed for a variety of imaging tasks in an elliptical phantom and an anthropomorphic head phantom. Results: Optimization of tube current modulation and view-dependent reconstruction kernel was shown to have greatest benefits for a directional task (e.g., identification of device or tissue orientation). The task-driven approach yielded techniques in which the dose and sharp kernels were concentrated in views contributing the most to the signal power associated with the imaging task. For example, detectability of a line pair detection task was improved by at least three fold compared to conventional approaches. For radially symmetric tasks, the task-driven strategy yielded results similar to a minimum variance strategy in the absence of kernel modulation. Optimization of the orbital tilt successfully avoided highly attenuating structures that can confound the imaging task by introducing noise correlations masquerading at spatial frequencies of interest. Conclusions: This work demonstrated the potential of a task

  2. Clinical Experience with Cone Beam CT Navigation for Tumor Ablation

    PubMed Central

    Abi-Jaoudeh, Nadine; Venkatesan, Aradhana M.; Van der Sterren, William; Radaelli, Alessandro; Carelsen, Bart; Wood, Bradford J.

    2015-01-01

    Purpose To describe clinical use and potential benefits of Cone Beam Computed Tomography (CBCT) navigation to perform image guided percutaneous tumor ablations. Materials and Methods All ablations performed between February 2011 and February 2013 using CBCT navigation, were included. Sixteen patients underwent 20 ablations for 29 lesions. CBCT ablation planning capabilities include multimodality image fusion and tumor segmentation for visualization, depiction of the predicted ablation zones for intra-procedural planning and segmentation of the ablated area for immediate post-treatment verification. Number and purpose of CBCT were examined. The initial ablation plan defined as number of probes and duration of energy delivery was recorded for 20/29 lesions. Technical success and local recurrences were recorded. Primary and secondary effectiveness rates were calculated. Results Image fusion was utilized for 16 lesions and intra-procedural ultrasound for 4. Of the 20/29 lesions, where the ablation plans were recorded, there was no deviation from the plan in 14. In the remaining 6/20, iterative planning was needed for complete tumor coverage. An average of 8.7 ± 3.2 CBCT were performed per procedure, including 1.3 ± 0.5 for tumor segmentation and planning, 1.7 ± 0.7 for probe position confirmation, 3.9 ± 2 to ensure complete coverage. Mean follow-up was 18.6 ± 6.5 months. 28/29 ablations were technically successful (96.5%). Of ablations performed with curative intent, technical effectiveness at one-month was 25/26 (96.1%) and 22/26 (84.6%) at last follow-up. Local tumor progression was observed in 11.5% (3/26). Conclusion CBCT navigation may add information to assist and improve ablation guidance and monitoring. PMID:25645409

  3. Cone-Beam Computed Tomography-Guided Percutaneous Radiologic Gastrostomy

    SciTech Connect

    Moehlenbruch, Markus; Nelles, Michael; Thomas, Daniel; Willinek, Winfried; Gerstner, Andreas; Schild, Hans H.; Wilhelm, Kai

    2010-04-15

    The purpose of this study was to investigate the feasibility of a flat-detector C-arm-guided radiographic technique (cone-beam computed tomography [CBCT]) for percutaneous radiologic gastrostomy (PRG) insertion. Eighteen patients (13 men and 5 women; mean age 62 years) in whom percutaneous endoscopic gastrostomy (PEG) had failed underwent CBCT-guided PRG insertion. PEG failure or unsuitability was caused by upper gastrointestinal tract obstruction in all cases. Indications for gastrostomy were esophageal and head and neck malignancies, respectively. Before the PRG procedure, initial C-arm CBCT scans were acquired. Three- and 2-dimensional soft-tissue reconstructions of the epigastrium region were generated on a dedicated workstation. Subsequently, gastropexy was performed with T-fasteners after CBCT-guided puncture of the stomach bubble, followed by insertion of an 14F balloon-retained catheter through a peel-away introducer. Puncture of the stomach bubble and PRG insertion was technically successful in all patients without alteration of the epigastric region. There was no malpositioning of the tube or other major periprocedural complications. In 2 patients, minor complications occurred during the first 30 days of follow-up (PRG malfunction: n = 1; slight infection: n = 1). Late complications, which were mainly tube disturbances, were observed in 2 patients. The mean follow-up time was 212 days. CBCT-guided PRG is a safe, well-tolerated, and successful method of gastrostomy insertion in patients in whom endoscopic gastrostomy is not feasible. CBCT provides detailed imaging of the soft tissue and surrounding structures of the epigastric region in one diagnostic tour and thus significantly improves the planning of PRG procedures.

  4. Automatic segmentation of maxillofacial cysts in cone beam CT images.

    PubMed

    Abdolali, Fatemeh; Zoroofi, Reza Aghaeizadeh; Otake, Yoshito; Sato, Yoshinobu

    2016-05-01

    Accurate segmentation of cysts and tumors is an essential step for diagnosis, monitoring and planning therapeutic intervention. This task is usually done manually, however manual identification and segmentation is tedious. In this paper, an automatic method based on asymmetry analysis is proposed which is general enough to segment various types of jaw cysts. The key observation underlying this approach is that normal head and face structure is roughly symmetric with respect to midsagittal plane: the left part and the right part can be divided equally by an axis of symmetry. Cysts and tumors typically disturb this symmetry. The proposed approach consists of three main steps as follows: At first, diffusion filtering is used for preprocessing and symmetric axis is detected. Then, each image is divided into two parts. In the second stage, free form deformation (FFD) is used to correct slight displacement of corresponding pixels of the left part and a reflected copy of the right part. In the final stage, intensity differences are analyzed and a number of constraints are enforced to remove false positive regions. The proposed method has been validated on 97 Cone Beam Computed Tomography (CBCT) sets containing various jaw cysts which were collected from various image acquisition centers. Validation is performed using three similarity indicators (Jaccard index, Dice's coefficient and Hausdorff distance). The mean Dice's coefficient of 0.83, 0.87 and 0.80 is achieved for Radicular, Dentigerous and KCOT classes, respectively. For most of the experiments done, we achieved high true positive (TP). This means that a large number of cyst pixels are correctly classified. Quantitative results of automatic segmentation show that the proposed method is more effective than one of the recent methods in the literature. PMID:27035862

  5. Task-driven imaging in cone-beam computed tomography

    PubMed Central

    Gang, G. J.; Stayman, J. W.; Ouadah, S.; Ehtiati, T.; Siewerdsen, J. H.

    2015-01-01

    Purpose Conventional workflow in interventional imaging often ignores a wealth of prior information of the patient anatomy and the imaging task. This work introduces a task-driven imaging framework that utilizes such information to prospectively design acquisition and reconstruction techniques for cone-beam CT (CBCT) in a manner that maximizes task-based performance in subsequent imaging procedures. Methods The framework is employed in jointly optimizing tube current modulation, orbital tilt, and reconstruction parameters in filtered backprojection reconstruction for interventional imaging. Theoretical predictors of noise and resolution relates acquisition and reconstruction parameters to task-based detectability. Given a patient-specific prior image and specification of the imaging task, an optimization algorithm prospectively identifies the combination of imaging parameters that maximizes task-based detectability. Initial investigations were performed for a variety of imaging tasks in an elliptical phantom and an anthropomorphic head phantom. Results Optimization of tube current modulation and view-dependent reconstruction kernel was shown to have greatest benefits for a directional task (e.g., identification of device or tissue orientation). The task-driven approach yielded techniques in which the dose and sharp kernels were concentrated in views contributing the most to the signal power associated with the imaging task. For example, detectability of a line pair detection task was improved by at least three fold compared to conventional approaches. For radially symmetric tasks, the task-driven strategy yielded results similar to a minimum variance strategy in the absence of kernel modulation. Optimization of the orbital tilt successfully avoided highly attenuating structures that can confound the imaging task by introducing noise correlations masquerading at spatial frequencies of interest. Conclusions This work demonstrated the potential of a task

  6. Radiation Exposure of Abdominal Cone Beam Computed Tomography

    SciTech Connect

    Sailer, Anna M.; Schurink, Geert Willem H.; Wildberger, Joachim E. Graaf, Rick de Zwam, Willem H. van Haan, Michiel W. de Kemerink, Gerrit J. Jeukens, Cécile R. L. P. N.

    2015-02-15

    PurposeTo evaluate patients radiation exposure of abdominal C-arm cone beam computed tomography (CBCT).MethodsThis prospective study was approved by the institutional review board; written, informed consent was waived. Radiation exposure of abdominal CBCT was evaluated in 40 patients who underwent CBCT during endovascular interventions. Dose area product (DAP) of CBCT was documented and effective dose (ED) was estimated based on organ doses using dedicated Monte Carlo simulation software with consideration of X-ray field location and patients’ individual body weight and height. Weight-dependent ED per DAP conversion factors were calculated. CBCT radiation dose was compared to radiation dose of procedural fluoroscopy. CBCT dose-related risk for cancer was assessed.ResultsMean ED of abdominal CBCT was 4.3 mSv (95 % confidence interval [CI] 3.9; 4.8 mSv, range 1.1–7.4 mSv). ED was significantly higher in the upper than in the lower abdomen (p = 0.003) and increased with patients’ weight (r = 0.55, slope = 0.045 mSv/kg, p < 0.001). Radiation exposure of CBCT corresponded to the radiation exposure of on average 7.2 fluoroscopy minutes (95 % CI 5.5; 8.8 min) in the same region of interest. Lifetime risk of exposure related cancer death was 0.033 % or less depending on age and weight.ConclusionsMean ED of abdominal CBCT was 4.3 mSv depending on X-ray field location and body weight.

  7. A virtual source model for Kilo-voltage cone beam CT: Source characteristics and model validation

    SciTech Connect

    Spezi, E.; Volken, W.; Frei, D.; Fix, M. K.

    2011-09-15

    Purpose: The purpose of this investigation was to study the source characteristics of a clinical kilo-voltage cone beam CT unit and to develop and validate a virtual source model that could be used for treatment planning purposes. Methods: We used a previously commissioned full Monte Carlo model and new bespoke software to study the source characteristics of a clinical kilo-voltage cone beam CT (CBCT) unit. We identified the main particle sources, their spatial, energy and angular distribution for all the image acquisition presets currently used in our clinical practice. This includes a combination of two energies (100 and 120 kVp), two filters (neutral and bowtie), and eight different x-ray beam apertures. We subsequently built a virtual source model which we validated against full Monte Carlo calculations. Results: We found that the radiation output of the clinical kilo-voltage cone beam CT unit investigated in this study could be reproduced with a virtual model comprising of two sources (target and filtration cone) or three sources (target, filtration cone and bowtie filter) when additional filtration was used. With this model, we accounted for more than 97% of the photons exiting the unit. Each source in our model was characterised by a origin distribution in both X and Y directions, a fluence map, a single energy spectrum for unfiltered beams and a two dimensional energy spectrum for bowtie filtered beams. The percentage dose difference between full Monte Carlo and virtual source model based dose distributions was well within the statistical uncertainty associated with the calculations ( {+-} 2%, one standard deviation) in all cases studied. Conclusions: The virtual source that we developed is accurate in calculating the dose delivered from a commercial kilo-voltage cone beam CT unit operating with routine clinical image acquisition settings. Our data have also shown that target, filtration cone, and bowtie filter sources needed to be all included in the model

  8. Actively triggered 4d cone-beam CT acquisition

    SciTech Connect

    Fast, Martin F.; Wisotzky, Eric; Oelfke, Uwe; Nill, Simeon

    2013-09-15

    Purpose: 4d cone-beam computed tomography (CBCT) scans are usually reconstructed by extracting the motion information from the 2d projections or an external surrogate signal, and binning the individual projections into multiple respiratory phases. In this “after-the-fact” binning approach, however, projections are unevenly distributed over respiratory phases resulting in inefficient utilization of imaging dose. To avoid excess dose in certain respiratory phases, and poor image quality due to a lack of projections in others, the authors have developed a novel 4d CBCT acquisition framework which actively triggers 2d projections based on the forward-predicted position of the tumor.Methods: The forward-prediction of the tumor position was independently established using either (i) an electromagnetic (EM) tracking system based on implanted EM-transponders which act as a surrogate for the tumor position, or (ii) an external motion sensor measuring the chest-wall displacement and correlating this external motion to the phase-shifted diaphragm motion derived from the acquired images. In order to avoid EM-induced artifacts in the imaging detector, the authors devised a simple but effective “Faraday” shielding cage. The authors demonstrated the feasibility of their acquisition strategy by scanning an anthropomorphic lung phantom moving on 1d or 2d sinusoidal trajectories.Results: With both tumor position devices, the authors were able to acquire 4d CBCTs free of motion blurring. For scans based on the EM tracking system, reconstruction artifacts stemming from the presence of the EM-array and the EM-transponders were greatly reduced using newly developed correction algorithms. By tuning the imaging frequency independently for each respiratory phase prior to acquisition, it was possible to harmonize the number of projections over respiratory phases. Depending on the breathing period (3.5 or 5 s) and the gantry rotation time (4 or 5 min), between ∼90 and 145

  9. Rotational artifacts in on-board cone beam computed tomography

    NASA Astrophysics Data System (ADS)

    Ali, E. S. M.; Webb, R.; Nyiri, B. J.

    2015-02-01

    Rotational artifacts in image guidance systems lead to registration errors that affect non-isocentric treatments and dose to off-axis organs-at-risk. This study investigates a rotational artifact in the images acquired with the on-board cone beam computed tomography system XVI (Elekta, Stockholm, Sweden). The goals of the study are to identify the cause of the artifact, to characterize its dependence on other quantities, and to investigate possible solutions. A 30 cm diameter cylindrical phantom is used to acquire clockwise and counterclockwise scans at five speeds (120 to 360 deg min-1) on six Elekta linear accelerators from three generations (MLCi, MLCi2 and Agility). Additional scans are acquired with different pulse widths and focal spot sizes for the same mAs. Image quality is evaluated using a common phantom with an in-house three dimensional contrast transfer function attachment. A robust, operator-independent analysis is developed which quantifies rotational artifacts with 0.02° accuracy and imaging system delays with 3 ms accuracy. Results show that the artifact is caused by mislabelling of the projections with a lagging angle due to various imaging system delays. For the most clinically used scan speed (360 deg min-1), the artifact is ˜0.5°, which corresponds to ˜0.25° error per scan direction with the standard Elekta procedure for angle calibration. This leads to a 0.5 mm registration error at 11 cm off-center. The artifact increases linearly with scan speed, indicating that the system delay is independent of scan speed. For the most commonly used pulse width of 40 ms, this delay is 34 ± 1 ms, part of which is half the pulse width. Results are consistent among the three linac generations. A software solution that corrects the angles of individual projections is shown to eliminate the rotational error for all scan speeds and directions. Until such a solution is available from the manufacturer, three clinical solutions are presented, which reduce the

  10. Ring artifact corrections in flat-panel detector based cone beam CT

    NASA Astrophysics Data System (ADS)

    Anas, Emran Mohammad Abu; Kim, Jaegon; Lee, Soo Yeol; Hasan, Md. Kamrul

    2011-03-01

    The use of flat-panel detectors (FPDs) is becoming increasingly popular in the cone beam volume and multi-slice CT imaging. But due to the deficient semiconductor array processing, the diagnostic quality of the FPD-based CT images in both CT systems is degraded by different types of artifacts known as the ring and radiant artifacts. Several techniques have been already published in eliminating the stripe artifacts from the projection data of the multi-slice CT system or in other words, from the sinogram image with a view to suppress the ring and radiant artifacts from the 2-D reconstructed CT images. On the other hand, till now a few articles have been reported to remove the artifacts from the cone beam CT images. In this paper, an effective approach is presented to eliminate the artifacts from the cone beam projection data using the sinogram based stripe artifact removal methods. The improvement in the required diagnostic quality is achieved by applying them both in horizontal and vertical sinograms constituted sequentially from the stacked cone beam projections. Finally, some real CT images have been used to demonstrate the effectiveness of the proposed technique in eliminating the ring and radiant artifacts from the cone beam volume CT images. A comparative study with the conventional sinogram based approaches is also presented to see the effectiveness of the proposed technique.

  11. Radiation Exposure of Patients by Cone Beam CT during Endobronchial Navigation - A Phantom Study

    PubMed Central

    Hohenforst-Schmidt, Wolfgang; Banckwitz, Rosemarie; Zarogoulidis, Paul; Vogl, Thomas; Darwiche, Kaid; Goldberg, Eugene; Huang, Haidong; Simoff, Michael; Li, Qiang; Browning, Robert; Freitag, Lutz; Turner, J Francis; Pivert, Patrick Le; Yarmus, Lonny; Zarogoulidis, Konstantinos; Brachmann, Johannes

    2014-01-01

    Rationale: Cone Beam Computed Tomography imaging has become increasingly important in many fields of interventional therapies. Objective: Lung navigation study which is an uncommon soft tissue approach. Methods: As no effective organ radiation dose levels were available for this kind of Cone Beam Computed Tomography application we simulated in our DynaCT (Siemens AG, Forchheim, Germany) suite 2 measurements including 3D acquisition and again for 3D acquisition and 4 endobronchial navigation maneuvers under fluoroscopy towards a nodule after the 8th segmentation in the right upper lobe over a total period of 20 minutes (min). These figures reflect the average complexity and time in our experience. We hereby describe the first time the exact protocol of lung navigation by a Cone Beam Computed Tomography approach. Measurement: The hereby first time measured body radiation doses in that approach showed very promising numbers between 0,98-1,15mSv giving specific lung radiation doses of 0,42-0,38 mSv. Main results: These figures are comparable or even better to other lung navigation systems. Cone Beam Computed Tomography offers some unique features for lung interventionists as a realtime 1-step navigation system in an open structure feasible for endobronchial and transcutaneous approach. Conclusions: Due to this low level of radiation exposure Cone Beam Computed Tomography is expected to attract interventionists interested in using and guiding endobronchial or transcutaneous ablative procedures to peripheral endobronchial and other lung lesions. PMID:24563674

  12. Evaluation of tilted cone-beam CT orbits in the development of a dedicated hybrid mammotomograph

    PubMed Central

    Crotty, D J; McKinley, R L; Tornai, M P

    2010-01-01

    A compact dedicated 3D breast SPECT-CT (mammotomography) system is currently under development. In its initial prototype, the cone-beam CT sub-system is restricted to a fixed-tilt circular rotation around the patient’s pendant breast. This study evaluated stationary-tilt angles for the CT subsystem that will enable maximal volumetric sampling and viewing of the breast and chest wall. Images of geometric/anthropomorphic phantoms were acquired using various fixed-tilt circular and 3D sinusoidal trajectories. The iteratively reconstructed images showed more distortion and attenuation coefficient inaccuracy from tilted cone-beam orbits than from the complex trajectory. Additionally, line profiles illustrated cupping artifacts in planes distal to the central plane of the tilted cone-beam, otherwise not apparent for images acquired with complex trajectories. This indicates that undersampled cone-beam data may be an additional cause of cupping artifacts. High-frequency objects could be distinguished for all trajectories, but their shapes and locations were corrupted by out-of-plane frequency information. Although more acrylic balls were visualized with a fixed-tilt and nearly flat cone-beam at the posterior of the breast, 3D complex trajectories have less distortion and more complete sampling throughout the reconstruction volume. While complex trajectories would ideally be preferred, negatively fixed-tilt source–detector configuration demonstrates minimally distorted patient images. PMID:19478374

  13. Asymptomatic radiopaque lesions of the jaws: a radiographic study using cone-beam computed tomography.

    PubMed

    Araki, Masao; Matsumoto, Naoyuki; Matsumoto, Kunihito; Ohnishi, Masaaki; Honda, Kazuya; Komiyama, Kazuo

    2011-12-01

    Panoramic radiography and cone-beam computed tomography (CT) were used to analyze asymptomatic radiopaque lesions in the jaw bones and determine the diagnostic relevance of the lesions based on their relationships to teeth and site of origin. One hundred radiopaque lesions detected between 1998 and 2002 were examined by both panoramic radiography and cone-beam CT. On the basis of panoramic radiographs, the region was classified as periapical, body, or edentulous, and the site was classified as molar or premolar. Follow-up data from medical records were available for only 36 of these cases. The study protocol for simultaneous use of cone-beam CT was approved by the ethics review board of our institution. A large majority of radiopaque lesions were observed in premolar and molar sites of the mandible; 60% of lesions were periapical, 24% were in the body, and 16% were in the edentulous region. An interesting type of radiopaque lesion, which we named a pearl shell structure (PSS), was observed on cone-beam CT in 34 of the 100 lesions. The PSS is a distinctive structure, and this finding on cone-beam CT likely represents the start of bone formation before bone sclerosis. PMID:22167028

  14. Hollow circular-truncated cone resonator and its hollow variable biconical laser beam

    NASA Astrophysics Data System (ADS)

    Liu, Jinglun; Chen, Mei; Wang, Qionghua; Sun, Nianchun

    2014-05-01

    To obtain a hollow variable biconical laser beam (HVBLB), a CO2 laser having a hollow circular-truncated cone resonator (HCTCR) is presented. This HCTCR comprises a rotationally symmetric total-reflecting concave mirror at the bottom, a rotationally symmetric part-reflecting convex mirror at the top, and a hollow circular-truncated cone discharge tube at the middle. The cross section of this generated biconical laser beam changes from annulus to circular to annulus and the size of this cross section from big to small to large as the propagation distance increases. So, a kind of laser beam with variable center intensity from zero to peak value to zero is obtained and is known as HVBLB. Due to the inclusion of part of the hollow laser beam (HLB) and solid laser beam, this HVBLB requires no additional beam-shaping element and has broad applications such as optical trapping and commercial manufacturing.

  15. Tetrahedron-based orthogonal simultaneous scan for cone-beam computed tomography

    PubMed Central

    Ye, Ivan B.; Wang, Ge

    2013-01-01

    In this article, a cone-beam computed tomography scanning mode is designed using four x-ray sources and a spherical sample. The x-ray sources are mounted at the vertices of a regular tetrahedron. On the circumsphere of the tetrahedron, four detection panels are mounted opposite of each vertex. To avoid x-ray interference, the largest half angle of each x-ray cone beam is 27°22′, while the radius of the largest ball fully covered by all the cone beams is 0.460, when the radius of the circumsphere is 1. A proposed scanning scheme consists of two rotations about orthogonal axes, such that, each quarter turn provides sufficient data for theoretically exact and stable reconstruction. This design can be used in biomedical or industrial settings, such as when a sequence of reconstructions of an object is desired. PMID:24058220

  16. Quantitative cone beam X-ray luminescence tomography/X-ray computed tomography imaging

    SciTech Connect

    Chen, Dongmei; Zhu, Shouping Chen, Xueli; Chao, Tiantian; Cao, Xu; Zhao, Fengjun; Huang, Liyu; Liang, Jimin

    2014-11-10

    X-ray luminescence tomography (XLT) is an imaging technology based on X-ray-excitable materials. The main purpose of this paper is to obtain quantitative luminescence concentration using the structural information of the X-ray computed tomography (XCT) in the hybrid cone beam XLT/XCT system. A multi-wavelength luminescence cone beam XLT method with the structural a priori information is presented to relieve the severe ill-posedness problem in the cone beam XLT. The nanophosphors and phantom experiments were undertaken to access the linear relationship of the system response. Then, an in vivo mouse experiment was conducted. The in vivo experimental results show that the recovered concentration error as low as 6.67% with the location error of 0.85 mm can be achieved. The results demonstrate that the proposed method can accurately recover the nanophosphor inclusion and realize the quantitative imaging.

  17. Cone beam computed tomography radiation dose and image quality assessments.

    PubMed

    Lofthag-Hansen, Sara

    2010-01-01

    Diagnostic radiology has undergone profound changes in the last 30 years. New technologies are available to the dental field, cone beam computed tomography (CBCT) as one of the most important. CBCT is a catch-all term for a technology comprising a variety of machines differing in many respects: patient positioning, volume size (FOV), radiation quality, image capturing and reconstruction, image resolution and radiation dose. When new technology is introduced one must make sure that diagnostic accuracy is better or at least as good as the one it can be expected to replace. The CBCT brand tested was two versions of Accuitomo (Morita, Japan): 3D Accuitomo with an image intensifier as detector, FOV 3 cm x 4 cm and 3D Accuitomo FPD with a flat panel detector, FOVs 4 cm x 4 cm and 6 cm x 6 cm. The 3D Accuitomo was compared with intra-oral radiography for endodontic diagnosis in 35 patients with 46 teeth analyzed, of which 41 were endodontically treated. Three observers assessed the images by consensus. The result showed that CBCT imaging was superior with a higher number of teeth diagnosed with periapical lesions (42 vs 32 teeth). When evaluating 3D Accuitomo examinations in the posterior mandible in 30 patients, visibility of marginal bone crest and mandibular canal, important anatomic structures for implant planning, was high with good observer agreement among seven observers. Radiographic techniques have to be evaluated concerning radiation dose, which requires well-defined and easy-to-use methods. Two methods: CT dose index (CTDI), prevailing method for CT units, and dose-area product (DAP) were evaluated for calculating effective dose (E) for both units. An asymmetric dose distribution was revealed when a clinical situation was simulated. Hence, the CTDI method was not applicable for these units with small FOVs. Based on DAP values from 90 patient examinations effective dose was estimated for three diagnostic tasks: implant planning in posterior mandible and

  18. Cone beam filtered backprojection (CB-FBP) image reconstruction by tracking re-sampled projection data

    NASA Astrophysics Data System (ADS)

    Tang, Xiangyang; Hsieh, Jiang; Nilsen, Roy A.; Mcolash, Scott M.

    2006-08-01

    The tomographic images reconstructed from cone beam projection data with a slice thickness larger than the nominal detector row width (namely thick image) is of practical importance in clinical CT imaging, such as neuro- and trauma- applications as well as applications for treatment planning in image guided radiation therapy. To get a balance optimization between image quality and computational efficiency, a cone beam filtered backprojection (CB-FBP) algorithm to reconstruct a thick image by tracking adaptively up-sampled cone beam projection of virtual reconstruction planes is proposed in this paper. Theoretically, a thick image is a weighted summation of a number of images with slice thickness corresponding to the nominal detector row width (namely thin image), and each thin image corresponds to a virtual reconstruction plane. To obtain the most achievable computational efficiency, the weighted summation has to be carried out in projection domain. However, it has been experimentally found that, to obtain a thick image with the reconstruction accuracy comparable to that of a thin image, the CB-FBP reconstruction algorithm has to be applied by tracking adaptively up-sampled cone beam projection data, which is the novelty of the proposed algorithm. The tracking process is carried out by making use of the cone beam projection data corresponding to the involved virtual reconstruction planes only, while the adaptive up-sampling process is implemented by interpolation along the z-direction at an adequate up-sampling rate. By using a helical body phantom, the performance of the proposed cone beam reconstruction algorithm, particularly its capability of suppressing artifacts, are experimentally evaluated and verified.

  19. Effects of scattered radiation and beam quality on low contrast performance in cone beam breast CT

    NASA Astrophysics Data System (ADS)

    Altunbas, M. Cem; Shaw, Chris; Chen, Lingyun; Wang, Tianpeng; Tu, Shuju

    2006-03-01

    In this work, we investigated the effects of scattered radiation and beam quality on the low contrast performance relevant to cone beam breast CT imaging. For experiments, we used our benchtop conebeam CT system and constructed a phantom consisting of simulated fat and soft tissues. We varied the field of view (FOV) along the z direction to observe its effect on scattered radiation. The beam quality was altered by varying the tube voltage from 50 to 100 kV. We computed the contrast-to-noise ratio (CNR) from reconstructed images and normalized it to the square root of dose measured at the center of the phantom. The results were used as the figure of merit (FOM). The effect of the beam quality on the scatter to primary ratio (SPR) had minimal impact and the SPR was primarily dominated by the FOV. In the central section of the phantom, increasing the FOV from 4 to 16 cm resulted in drop of CNR in the order of 15-20% at any given kVp setting. For a given FOV, the beam quality had insignificant effect on the FOM in the central section of the phantom. In the peripheral section, a 10 % drop in FOM was observed when the kVp setting was increased from 50 to 100. At lower kVp values, the primary x-ray transmission through the thicker parts of the phantom was severely reduced. Under such circumstances, ring artifacts were observed due to imperfect flat field correction at very low signal intensities. Higher kVp settings and higher SPRs helped to increase the signal intensity in highly attenuating regions and suppressed the ring artifacts.

  20. How I Do It: Cone-Beam CT during Transarterial Chemoembolization for Liver Cancer

    PubMed Central

    Tacher, Vania; Radaelli, Alessandro; Lin, MingDe

    2015-01-01

    Cone-beam computed tomography (CBCT) is an imaging technique that provides computed tomographic (CT) images from a rotational scan acquired with a C-arm equipped with a flat panel detector. Utilizing CBCT images during interventional procedures bridges the gap between the world of diagnostic imaging (typically three-dimensional imaging but performed separately from the procedure) and that of interventional radiology (typically two-dimensional imaging). CBCT is capable of providing more information than standard two-dimensional angiography in localizing and/or visualizing liver tumors (“seeing” the tumor) and targeting tumors though precise microcatheter placement in close proximity to the tumors (“reaching” the tumor). It can also be useful in evaluating treatment success at the time of procedure (“assessing” treatment success). CBCT technology is rapidly evolving along with the development of various contrast material injection protocols and multiphasic CBCT techniques. The purpose of this article is to provide a review of the principles of CBCT imaging, including purpose and clinical evidence of the different techniques, and to introduce a decision-making algorithm as a guide for the routine utilization of CBCT during transarterial chemoembolization of liver cancer. © RSNA, 2015 Online supplemental material is available for this article. PMID:25625741

  1. Segmentation of cone-beam CT using a hidden Markov random field with informative priors

    NASA Astrophysics Data System (ADS)

    Moores, M.; Hargrave, C.; Harden, F.; Mengersen, K.

    2014-03-01

    Cone-beam computed tomography (CBCT) has enormous potential to improve the accuracy of treatment delivery in image-guided radiotherapy (IGRT). To assist radiotherapists in interpreting these images, we use a Bayesian statistical model to label each voxel according to its tissue type. The rich sources of prior information in IGRT are incorporated into a hidden Markov random field model of the 3D image lattice. Tissue densities in the reference CT scan are estimated using inverse regression and then rescaled to approximate the corresponding CBCT intensity values. The treatment planning contours are combined with published studies of physiological variability to produce a spatial prior distribution for changes in the size, shape and position of the tumour volume and organs at risk. The voxel labels are estimated using iterated conditional modes. The accuracy of the method has been evaluated using 27 CBCT scans of an electron density phantom. The mean voxel-wise misclassification rate was 6.2%, with Dice similarity coefficient of 0.73 for liver, muscle, breast and adipose tissue. By incorporating prior information, we are able to successfully segment CBCT images. This could be a viable approach for automated, online image analysis in radiotherapy.

  2. Micro-cone targets for producing high energy and low divergence particle beams

    DOEpatents

    Le Galloudec, Nathalie

    2013-09-10

    The present invention relates to micro-cone targets for producing high energy and low divergence particle beams. In one embodiment, the micro-cone target includes a substantially cone-shaped body including an outer surface, an inner surface, a generally flat and round, open-ended base, and a tip defining an apex. The cone-shaped body tapers along its length from the generally flat and round, open-ended base to the tip defining the apex. In addition, the outer surface and the inner surface connect the base to the tip, and the tip curves inwardly to define an outer surface that is concave, which is bounded by a rim formed at a juncture where the outer surface meets the tip.

  3. 3D Algebraic Iterative Reconstruction for Cone-Beam X-Ray Differential Phase-Contrast Computed Tomography

    PubMed Central

    Fu, Jian; Hu, Xinhua; Velroyen, Astrid; Bech, Martin; Jiang, Ming; Pfeiffer, Franz

    2015-01-01

    Due to the potential of compact imaging systems with magnified spatial resolution and contrast, cone-beam x-ray differential phase-contrast computed tomography (DPC-CT) has attracted significant interest. The current proposed FDK reconstruction algorithm with the Hilbert imaginary filter will induce severe cone-beam artifacts when the cone-beam angle becomes large. In this paper, we propose an algebraic iterative reconstruction (AIR) method for cone-beam DPC-CT and report its experiment results. This approach considers the reconstruction process as the optimization of a discrete representation of the object function to satisfy a system of equations that describes the cone-beam DPC-CT imaging modality. Unlike the conventional iterative algorithms for absorption-based CT, it involves the derivative operation to the forward projections of the reconstructed intermediate image to take into account the differential nature of the DPC projections. This method is based on the algebraic reconstruction technique, reconstructs the image ray by ray, and is expected to provide better derivative estimates in iterations. This work comprises a numerical study of the algorithm and its experimental verification using a dataset measured with a three-grating interferometer and a mini-focus x-ray tube source. It is shown that the proposed method can reduce the cone-beam artifacts and performs better than FDK under large cone-beam angles. This algorithm is of interest for future cone-beam DPC-CT applications. PMID:25775480

  4. Optimizing Cone Beam Computed Tomography (CBCT) System for Image Guided Radiation Therapy

    NASA Astrophysics Data System (ADS)

    Park, Chun Joo

    Cone Beam Computed Tomography (CBCT) system is the most widely used imaging device in image guided radiation therapy (IGRT), where set of 3D volumetric image of patient can be reconstructed to identify and correct position setup errors prior to the radiation treatment. This CBCT system can significantly improve precision of on-line setup errors of patient position and tumor target localization prior to the treatment. However, there are still a number of issues that needs to be investigated with CBCT system such as 1) progressively increasing defective pixels in imaging detectors by its frequent usage, 2) hazardous radiation exposure to patients during the CBCT imaging, 3) degradation of image quality due to patients' respiratory motion when CBCT is acquired and 4) unknown knowledge of certain anatomical features such as liver, due to lack of soft-tissue contrast which makes tumor motion verification challenging. In this dissertation, we explore on optimizing the use of cone beam computed tomography (CBCT) system under such circumstances. We begin by introducing general concept of IGRT. We then present the development of automated defective pixel detection algorithm for X-ray imagers that is used for CBCT imaging using wavelet analysis. We next investigate on developing fast and efficient low-dose volumetric reconstruction techniques which includes 1) fast digital tomosynthesis reconstruction using general-purpose graphics processing unit (GPGPU) programming and 2) fast low-dose CBCT image reconstruction based on the Gradient-Projection-Barzilai-Borwein formulation (GP-BB). We further developed two efficient approaches that could reduce the degradation of CBCT images from respiratory motion. First, we propose reconstructing four dimensional (4D) CBCT and DTS using respiratory signal extracted from fiducial markers implanted in liver. Second, novel motion-map constrained image reconstruction (MCIR) is proposed that allows reconstruction of high quality and high phase

  5. Breath-Hold Target Localization With Simultaneous Kilovoltage/Megavoltage Cone-Beam Computed Tomography and Fast Reconstruction

    SciTech Connect

    Blessing, Manuel; Stsepankou, Dzmitry; Wertz, Hansjoerg; Arns, Anna; Lohr, Frank; Hesser, Juergen; Wenz, Frederik

    2010-11-15

    Purpose: Hypofractionated high-dose radiotherapy for small lung tumors has typically been based on stereotaxy. Cone-beam computed tomography and breath-hold techniques have provided a noninvasive basis for precise cranial and extracranial patient positioning. The cone-beam computed tomography acquisition time of 60 s, however, is beyond the breath-hold capacity of patients, resulting in respiratory motion artifacts. By combining megavoltage (MV) and kilovoltage (kV) photon sources (mounted perpendicularly on the linear accelerator) and accelerating the gantry rotation to the allowed limit, the data acquisition time could be reduced to 15 s. Methods and Materials: An Elekta Synergy 6-MV linear accelerator, with iViewGT as the MV- and XVI as the kV-imaging device, was used with a Catphan phantom and an anthropomorphic thorax phantom. Both image sources performed continuous image acquisition, passing an angle interval of 90{sup o} within 15 s. For reconstruction, filtered back projection on a graphics processor unit was used. It reconstructed 100 projections acquired to a 512 x 512 x 512 volume within 6 s. Results: The resolution in the Catphan phantom (CTP528 high-resolution module) was 3 lines/cm. The spatial accuracy was within 2-3 mm. The diameters of different tumor shapes in the thorax phantom were determined within an accuracy of 1.6 mm. The signal-to-noise ratio was 68% less than that with a 180{sup o}-kV scan. The dose generated to acquire the MV frames accumulated to 82.5 mGy, and the kV contribution was <6 mGy. Conclusion: The present results have shown that fast breath-hold, on-line volume imaging with a linear accelerator using simultaneous kV-MV cone-beam computed tomography is promising and can potentially be used for image-guided radiotherapy for lung cancer patients in the near future.

  6. Comparison of fan-beam, cone-beam, and spiral scan reconstruction in x-ray micro-CT

    NASA Astrophysics Data System (ADS)

    Sasov, Alexander

    2001-06-01

    We developed and tested reconstruction software packages for different algorithms: fan-beam, cone-beam (Feldkamp) and spiral (helical) scans. All algorithms were applied to different simulations as well as to the real datasets from the commercial micro-CT instruments. From the results of testing a number of strong and weak points at different approaches was found. Several examples from the different application areas (bone microstructure, industrial applications) show typical reconstruction artifacts with different algorithms.

  7. The application of cone-beam CT in the aging of bone calluses: a new perspective?

    PubMed

    Cappella, A; Amadasi, A; Gaudio, D; Gibelli, D; Borgonovo, S; Di Giancamillo, M; Cattaneo, C

    2013-11-01

    In the forensic and anthropological fields, the assessment of the age of a bone callus can be crucial for a correct analysis of injuries in the skeleton. To our knowledge, the studies which have focused on this topic are mainly clinical and still leave much to be desired for forensic purposes, particularly in looking for better methods for aging calluses in view of criminalistic applications. This study aims at evaluating the aid cone-beam CT can give in the investigation of the inner structure of fractures and calluses, thus acquiring a better knowledge of the process of bone remodeling. A total of 13 fractures (three without callus formation and ten with visible callus) of known age from cadavers were subjected to radiological investigations with digital radiography (DR) (conventional radiography) and cone-beam CT with the major aim of investigating the differences between DR and tomographic images when studying the inner and outer structures of bone healing. Results showed how with cone-beam CT the structure of the callus is clearly visible with higher specificity and definition and much more information on mineralization in different sections and planes. These results could lay the foundation for new perspectives on bone callus evaluation and aging with cone-beam CT, a user-friendly and skillful technique which in some instances can also be used extensively on the living (e.g., in cases of child abuse) with reduced exposition to radiation. PMID:23389391

  8. A Reconstruction Approach for Imaging in 3D Cone Beam Vector Field Tomography

    PubMed Central

    Schuster, T.; Theis, D.; Louis, A. K.

    2008-01-01

    3D cone beam vector field tomography (VFT) aims for reconstructing and visualizing the velocity field of a moving fluid by measuring line integrals of projections of the vector field. The data are obtained by ultrasound measurements along a scanning curve which surrounds the object. From a mathematical point of view, we have to deal with the inversion of the vectorial cone beam transform. Since the vectorial cone beam transform of any gradient vector field with compact support is identically equal to zero, we can only hope to reconstruct the solenoidal part of an arbitrary vector field. In this paper we will at first summarize important properties of the cone beam transform for three-dimensional solenoidal vector fields and then propose a solution approach based on the method of approximate inverse. In this context, we intensively make use of results from scalar 3D computerized tomography. The findings presented in the paper will continuously be illustrated by pictures from first numerical experiments done with exact, simulated data. PMID:19197391

  9. Point spread function modeling and image restoration for cone-beam CT

    NASA Astrophysics Data System (ADS)

    Zhang, Hua; Huang, Kui-Dong; Shi, Yi-Kai; Xu, Zhe

    2015-03-01

    X-ray cone-beam computed tomography (CT) has such notable features as high efficiency and precision, and is widely used in the fields of medical imaging and industrial non-destructive testing, but the inherent imaging degradation reduces the quality of CT images. Aimed at the problems of projection image degradation and restoration in cone-beam CT, a point spread function (PSF) modeling method is proposed first. The general PSF model of cone-beam CT is established, and based on it, the PSF under arbitrary scanning conditions can be calculated directly for projection image restoration without the additional measurement, which greatly improved the application convenience of cone-beam CT. Secondly, a projection image restoration algorithm based on pre-filtering and pre-segmentation is proposed, which can make the edge contours in projection images and slice images clearer after restoration, and control the noise in the equivalent level to the original images. Finally, the experiments verified the feasibility and effectiveness of the proposed methods. Supported by National Science and Technology Major Project of the Ministry of Industry and Information Technology of China (2012ZX04007021), Young Scientists Fund of National Natural Science Foundation of China (51105315), Natural Science Basic Research Program of Shaanxi Province of China (2013JM7003) and Northwestern Polytechnical University Foundation for Fundamental Research (JC20120226, 3102014KYJD022)

  10. Contours identification of elements in a cone beam computed tomography for investigating maxillary cysts

    NASA Astrophysics Data System (ADS)

    Chioran, Doina; Nicoarǎ, Adrian; Roşu, Şerban; Cǎrligeriu, Virgil; Ianeş, Emilia

    2013-10-01

    Digital processing of two-dimensional cone beam computer tomography slicesstarts by identification of the contour of elements within. This paper deals with the collective work of specialists in medicine and applied mathematics in computer science on elaborating and implementation of algorithms in dental 2D imagery.

  11. Cone-beam computed tomography: An inevitable investigation in cleidocranial dysplasia

    PubMed Central

    Gupta, Nandita S.; Gogri, Ajas A.; Kajale, Manasi M.; Kadam, Sonali G.

    2015-01-01

    Cleidocranial dysplasia is a heritable skeletal dysplasia and one of the most common features of this syndrome is multiple impacted supernumerary teeth. Cone-beam computed tomography, the most recent advancement in maxillofacial imaging, provides the clinician to view the morphology of the skull and the dentition in all three dimensions and help in treatment planning for the patient. PMID:26097368

  12. Patient dose from kilovoltage cone beam computed tomography imaging in radiation therapy

    SciTech Connect

    Islam, Mohammad K.; Purdie, Thomas G.; Norrlinger, Bernhard D.; Alasti, Hamideh; Moseley, Douglas J.; Sharpe, Michael B.; Siewerdsen, Jeffrey H.; Jaffray, David A.

    2006-06-15

    Kilovoltage cone-beam computerized tomography (kV-CBCT) systems integrated into the gantry of linear accelerators can be used to acquire high-resolution volumetric images of the patient in the treatment position. Using on-line software and hardware, patient position can be determined accurately with a high degree of precision and, subsequently, set-up parameters can be adjusted to deliver the intended treatment. While the patient dose due to a single volumetric imaging acquisition is small compared to the therapy dose, repeated and daily image guidance procedures can lead to substantial dose to normal tissue. The dosimetric properties of a clinical CBCT system have been studied on an Elekta linear accelerator (Synergy[reg] RP, XVI system) and additional measurements performed on a laboratory system with identical geometry. Dose measurements were performed with an ion chamber and MOSFET detectors at the center, periphery, and surface of 30 and 16-cm-diam cylindrical shaped water phantoms, as a function of x-ray energy and longitudinal field-of-view (FOV) settings of 5,10,15, and 26 cm. The measurements were performed for full 360 deg.CBCT acquisition as well as for half-rotation scans for 120 kVp beams using the 30-cm-diam phantom. The dose at the center and surface of the body phantom were determined to be 1.6 and 2.3 cGy for a typical imaging protocol, using full rotation scan, with a technique setting of 120 kVp and 660 mAs. The results of our measurements have been presented in terms of a dose conversion factor f{sub CBCT}, expressed in cGy/R. These factors depend on beam quality and phantom size as well as on scan geometry and can be utilized to estimate dose for any arbitrary mAs setting and reference exposure rate of the x-ray tube at standard distance. The results demonstrate the opportunity to manipulate the scanning parameters to reduce the dose to the patient by employing lower energy (kVp) beams, smaller FOV, or by using half-rotation scan.

  13. Regularized iterative weighted filtered backprojection for helical cone-beam CT.

    PubMed

    Sunnegårdh, Johan; Danielsson, Per-Erik

    2008-09-01

    Contemporary reconstruction methods employed for clinical helical cone-beam computed tomography (CT) are analytical (noniterative) but mathematically nonexact, i.e., the reconstructed image contains so called cone-beam artifacts, especially for higher cone angles. Besides cone artifacts, these methods also suffer from windmill artifacts: alternating dark and bright regions creating spiral-like patterns occurring in the vicinity of high z-direction derivatives. In this article, the authors examine the possibility to suppress cone and windmill artifacts by means of iterative application of nonexact three-dimensional filtered backprojection, where the analytical part of the reconstruction brings about accelerated convergence. Specifically, they base their investigations on the weighted filtered backprojection method [Stierstorfer et al., Phys. Med. Biol. 49, 2209-2218 (2004)]. Enhancement of high frequencies and amplification of noise is a common but unwanted side effect in many acceleration attempts. They have employed linear regularization to avoid these effects and to improve the convergence properties of the iterative scheme. Artifacts and noise, as well as spatial resolution in terms of modulation transfer functions and slice sensitivity profiles have been measured. The results show that for cone angles up to +/-2.78 degrees, cone artifacts are suppressed and windmill artifacts are alleviated within three iterations. Furthermore, regularization parameters controlling spatial resolution can be tuned so that image quality in terms of spatial resolution and noise is preserved. Simulations with higher number of iterations and long objects (exceeding the measured region) verify that the size of the reconstructible region is not reduced, and that the regularization greatly improves the convergence properties of the iterative scheme. Taking these results into account, and the possibilities to extend the proposed method with more accurate modeling of the acquisition

  14. Comparison of Swedish and Norwegian Use of Cone-Beam Computed Tomography: a Questionnaire Study

    PubMed Central

    Strindberg, Jerker Edén; Hol, Caroline; Torgersen, Gerald; Møystad, Anne; Nilsson, Mats; Hellén-Halme, Kristina

    2015-01-01

    ABSTRACT Objectives Cone-beam computed tomography in dentistry can be used in some countries by other dentists than specialists in radiology. The frequency of buying cone-beam computed tomography to examine patients is rapidly growing, thus knowledge of how to use it is very important. The aim was to compare the outcome of an investigation on the use of cone-beam computed tomography in Sweden with a previous Norwegian study, regarding specifically technical aspects. Material and Methods The questionnaire contained 45 questions, including 35 comparable questions to Norwegian clinics one year previous. Results were based on inter-comparison of the outcome from each of the two questionnaire studies. Results Responses rate was 71% in Sweden. There, most of cone-beam computed tomography (CBCT) examinations performed by dental nurses, while in Norway by specialists. More than two-thirds of the CBCT units had a scout image function, regularly used in both Sweden (79%) and Norway (75%). In Sweden 4% and in Norway 41% of the respondents did not wait for the report from the radiographic specialist before initiating treatment. Conclusions The bilateral comparison showed an overall similarity between the two countries. The survey gave explicit and important knowledge of the need for education and training of the whole team, since radiation dose to the patient could vary a lot for the same kind of radiographic examination. It is essential to establish quality assurance protocols with defined responsibilities in the team in order to maintain high diagnostic accuracy for all examinations when using cone-beam computed tomography for patient examinations. PMID:26904179

  15. Effectiveness of limited cone-beam computed tomography in the detection of horizontal root fracture.

    PubMed

    Kamburoğlu, Kivanç; Ilker Cebeci, A R; Gröndahl, Hans Göran

    2009-06-01

    To compare the diagnostic accuracy of conventional film radiography, charge coupled device (CCD) and photostimulable phosphor plate (PSP) digital images and limited cone-beam computed tomography in detecting simulated horizontal root fracture. Root fractures were created in the horizontal plane in 18 teeth by a mechanical force and fragments were relocated. Another 18 intact teeth with no horizontal root fracture served as a control group. Thirty-six teeth were placed in the respective empty maxillary anterior sockets of a human dry skull in groups three by three. Intraoral radiographs were obtained in three different vertical views by utilizing Eastman Kodak E-speed film, CCD sensor, RVG 5.0 Trophy and a PSP sensor Digora, Optime. Cone beam CT images were taken with a unit (3D Accuitomo; J Morita MFG. Corp, Kyoto, Japan). Three dental radiologists separately examined the intraoral film, PSP, CCD and cone beam CT images for the presence of horizontal root fracture. Specificity and sensitivity for each radiographic technique were calculated. Kappa statistics was used for assessing the agreement between observers. Chi-square statistics was used to determine whether there were differences between the systems. Results were considered significant at P < 0.05. Cone beam CT images revealed significantly higher sensitivities (P < 0.05) than the intraoral systems between which no significant differences were found. Specificities did not show any statistically significant differences between any of the four systems. The kappa values for inter-observer agreement between observers (four pairs) ranged between 0.82-0.90 for the 3DX evaluations and between 0.63-0.71 for the different types of intraoral images. Limited cone beam CT, outperformed the two-dimensional intraoral, conventional as well as digital, radiographic methods in detecting simulated horizontal root fracture. PMID:19583573

  16. Evaluation of the OSC-TV iterative reconstruction algorithm for cone-beam optical CT

    SciTech Connect

    Matenine, Dmitri Mascolo-Fortin, Julia; Goussard, Yves

    2015-11-15

    Purpose: The present work evaluates an iterative reconstruction approach, namely, the ordered subsets convex (OSC) algorithm with regularization via total variation (TV) minimization in the field of cone-beam optical computed tomography (optical CT). One of the uses of optical CT is gel-based 3D dosimetry for radiation therapy, where it is employed to map dose distributions in radiosensitive gels. Model-based iterative reconstruction may improve optical CT image quality and contribute to a wider use of optical CT in clinical gel dosimetry. Methods: This algorithm was evaluated using experimental data acquired by a cone-beam optical CT system, as well as complementary numerical simulations. A fast GPU implementation of OSC-TV was used to achieve reconstruction times comparable to those of conventional filtered backprojection. Images obtained via OSC-TV were compared with the corresponding filtered backprojections. Spatial resolution and uniformity phantoms were scanned and respective reconstructions were subject to evaluation of the modulation transfer function, image uniformity, and accuracy. The artifacts due to refraction and total signal loss from opaque objects were also studied. Results: The cone-beam optical CT data reconstructions showed that OSC-TV outperforms filtered backprojection in terms of image quality, thanks to a model-based simulation of the photon attenuation process. It was shown to significantly improve the image spatial resolution and reduce image noise. The accuracy of the estimation of linear attenuation coefficients remained similar to that obtained via filtered backprojection. Certain image artifacts due to opaque objects were reduced. Nevertheless, the common artifact due to the gel container walls could not be eliminated. Conclusions: The use of iterative reconstruction improves cone-beam optical CT image quality in many ways. The comparisons between OSC-TV and filtered backprojection presented in this paper demonstrate that OSC-TV can

  17. Assessment of residual error in liver position using kV cone-beam computed tomography for liver cancer high-precision radiation therapy

    SciTech Connect

    Hawkins, Maria A.; Brock, Kristy K.; Eccles, Cynthia; Moseley, Douglas; Jaffray, David; Dawson, Laura A. . E-mail: laura.dawson@rmp.uhn.on.ca

    2006-10-01

    Purpose: To evaluate the residual error in liver position using breath-hold kilovoltage (kV) cone-beam computed tomography (CT) following on-line orthogonal megavoltage (MV) image-guided breath-hold liver cancer conformal radiotherapy. Methods and Materials: Thirteen patients with liver cancer treated with 6-fraction breath-hold conformal radiotherapy were investigated. Before each fraction, orthogonal MV images were obtained during exhale breath-hold, with repositioning for offsets >3 mm, using the diaphragm for cranio-caudal (CC) alignment and vertebral bodies for medial-lateral (ML) and anterior posterior (AP) alignment. After repositioning, repeat orthogonal MV images, orthogonal kV fluoroscopic movies, and kV cone-beam CTs were obtained in exhale breath-hold. The cone-beam CT livers were registered to the planning CT liver to obtain the residual setup error in liver position. Results: After repositioning, 78 orthogonal MV image pairs, 61 orthogonal kV image pairs, and 72 kV cone-beam CT scans were obtained. Population random setup errors ({sigma}) in liver position were 2.7 mm (CC), 2.3 mm (ML), and 3.0 mm (AP), and systematic errors ({sigma}) were 1.1 mm, 1.9 mm, and 1.3 mm in the superior, medial, and posterior directions. Liver offsets >5 mm were observed in 33% of cases; offsets >10 mm and liver deformation >5 mm were observed in a minority of patients. Conclusions: Liver position after radiation therapy guided with MV orthogonal imaging was within 5 mm of planned position in the majority of patients. kV cone-beam CT image guidance should improve accuracy with reduced dose compared with orthogonal MV image guidance for liver cancer radiation therapy.

  18. Feasibility of a Modified cone-Beam cT rotation Trajectory to improve liver Periphery Visualization during Transarterial chemoembolization

    PubMed Central

    Schernthaner, Rüdiger E.; Chapiro, Julius; Sahu, Sonia; Withagen, Paul; Duran, Rafael; Sohn, Jae Ho; Radaelli, Alessandro; van der Bom, Imramsjah Martin; Geschwind, Jean-François H.; Lin, MingDe

    2015-01-01

    Purpose To compare liver coverage and tumor detectability by using preprocedural magnetic resonance (MR) images as a reference, as well as radiation exposure of cone-beam computed tomography (CT) with different rotational trajectories. Materials and Methods Fifteen patients (nine men and six women; mean age ± standard deviation, 65 years ± 5) with primary or secondary liver cancer were retrospectively included in this institutional review board–approved study. A modified conebeam CT protocol was used in which the C-arm rotates from +55° to –185° (open arc cone-beam CT) instead of –120° to +120° (closed arc cone-beam CT). Each patient underwent two sessions of transarterial chemoembolization between February 2013 and March 2014 with closed arc and open arc cone-beam CT (during the first and second transarterial chemoembolization sessions, respectively, as part of the institutional transarterial chemoembolization protocol). For each cone-beam CT examination, liver volume and tumor detectability were assessed by using MR images as the reference. Radiation exposure was compared by means of a phantom study. For statistical analysis, paired t tests and a Wilcoxon signed rank test were performed. Results Mean liver volume imaged was 1695 cm3 ± 542 and 1857 cm3 ± 571 at closed arc and open arc cone-beam CT, respectively. The coverage of open arc cone-beam CT was significantly higher compared with closed arc cone-beam CT (97% vs 86% of the MR imaging liver volume, P = .002). In eight patients (53%), tumors were partially or completely outside the closed arc cone-beam CT field of view. All tumors were within the open arc cone-beam CT field of view. The open arc cone-beam CT radiation exposure by means of weighted CT index was slightly lower compared with that of closed arc cone-beam CT (–5.1%). Conclusion Open arc cone-beam CT allowed for a significantly improved intraprocedural depiction of peripheral hepatic tumors while achieving a slight radiation

  19. Stray light in cone beam optical computed tomography: II. Reduction using a convergent light source.

    PubMed

    Dekker, Kurtis H; Battista, Jerry J; Jordan, Kevin J

    2016-04-01

    Optical cone beam computed tomography (CBCT) using a broad beam and CCD camera is a fast method for densitometry of 3D optical gel dosimeters. However, diffuse light sources introduce considerable stray light into the imaging system, leading to underestimation of attenuation coefficients and non-uniformities in CT images unless corrections are applied to each projection image. In this study, the light source of a commercial optical CT scanner is replaced with a convergent cone beam source consisting of almost exclusively image forming primary rays. The convergent source is achieved using a small isotropic source and a Fresnel lens. To characterize stray light effects, full-field cone beam CT imaging is compared to fan beam CT (FBCT) using a 1 cm high fan beam aperture centered on the optic axis of the system. Attenuating liquids are scanned within a large 96 mm diameter uniform phantom and in a small 13.5 mm diameter finger phantom. For the uniform phantom, cone and fan beam CT attenuation coefficients agree within a maximum deviation of (1  ±  2)% between mean values over a wide range from 0.036 to 0.43 cm(-1). For the finger phantom, agreement is found with a maximum deviation of (4  ±  2)% between mean values over a range of 0.1-0.47 cm(-1). With the convergent source, artifacts associated with refractive index mismatch and vessel optical features are more pronounced. Further optimization of the source size to achieve a balance between quantitative accuracy and artifact reduction should enable practical, accurate 3D dosimetry, avoiding time consuming 3D scatter measurements. PMID:26988107

  20. Stray light in cone beam optical computed tomography: II. Reduction using a convergent light source

    NASA Astrophysics Data System (ADS)

    Dekker, Kurtis H.; Battista, Jerry J.; Jordan, Kevin J.

    2016-04-01

    Optical cone beam computed tomography (CBCT) using a broad beam and CCD camera is a fast method for densitometry of 3D optical gel dosimeters. However, diffuse light sources introduce considerable stray light into the imaging system, leading to underestimation of attenuation coefficients and non-uniformities in CT images unless corrections are applied to each projection image. In this study, the light source of a commercial optical CT scanner is replaced with a convergent cone beam source consisting of almost exclusively image forming primary rays. The convergent source is achieved using a small isotropic source and a Fresnel lens. To characterize stray light effects, full-field cone beam CT imaging is compared to fan beam CT (FBCT) using a 1 cm high fan beam aperture centered on the optic axis of the system. Attenuating liquids are scanned within a large 96 mm diameter uniform phantom and in a small 13.5 mm diameter finger phantom. For the uniform phantom, cone and fan beam CT attenuation coefficients agree within a maximum deviation of (1  ±  2)% between mean values over a wide range from 0.036 to 0.43 cm-1. For the finger phantom, agreement is found with a maximum deviation of (4  ±  2)% between mean values over a range of 0.1-0.47 cm-1. With the convergent source, artifacts associated with refractive index mismatch and vessel optical features are more pronounced. Further optimization of the source size to achieve a balance between quantitative accuracy and artifact reduction should enable practical, accurate 3D dosimetry, avoiding time consuming 3D scatter measurements.

  1. Cone-beam differential phase-contrast laminography with x-ray tube source

    NASA Astrophysics Data System (ADS)

    Fu, J.; Biernath, T.; Willner, M.; Amberger, M.; Meiser, J.; Kunka, D.; Mohr, J.; Herzen, J.; Bech, M.; Pfeiffer, F.

    2014-06-01

    We report on an x-ray cone-beam differential phase-contrast computed laminography (DPC-CL) method for tomographic reconstruction of thin and lamellar objects. We describe the specific scan geometry of DPC-CL, which consists of a Talbot-Lau grating interferometer and a lab-based x-ray tube source, and derive a filtered back-projection (FBP) reconstruction algorithm. The experimental results of a flat sphere phantom and a piece of ham demonstrate the validity of the proposed technique. The existing DPC-CL methods are based on synchrotron sources and the parallel-beam geometry. In contrast, our approach adopts a more accessible x-ray tube source and a cone-beam geometry. Therefore it significantly widens the application range of phase-contrast laminography, particularly in practical laboratory settings, beyond applications at large-scale synchrotron facilities.

  2. An intracavitary cone system for electron beam therapy using a Therac 20 linear accelerator.

    PubMed

    Wilson, D L; Sharma, S C; Jose, B

    1986-06-01

    The Therac 20 is an AECL medical linear accelerator that produces electron and photon beams. Electron fields are produced by a scanned beam; collimation is provided by two sets of primary collimators and further collimated by external electron trimmers located 11 cm above the plane of isocenter (100 cm). These collimators are not suitable for intracavitary treatment. To overcome this limitation, we have designed an intracavitary cone system that attaches to the electron trimmers. Since the trimmers do not have to be removed while this system is in use, there is no need to bypass the associated interlock system. The apparatus consists of a platform which slides onto the lower set of trimmers, onto which a lead insert is attached. Dosimetry measurements for 9, 13, and 17 MeV electron beams are reported for three different treatment cones. PMID:3721928

  3. Single-slice rebinning method for helical cone-beam CT.

    PubMed

    Noo, F; Defrise, M; Clackdoyle, R

    1999-02-01

    In this paper, we present reconstruction results from helical cone-beam CT data, obtained using a simple and fast algorithm, which we call the CB-SSRB algorithm. This algorithm combines the single-slice rebinning method of PET imaging with the weighting schemes of spiral CT algorithms. The reconstruction is approximate but can be performed using 2D multislice fan-beam filtered backprojection. The quality of the results is surprisingly good, and far exceeds what one might expect, even when the pitch of the helix is large. In particular, with this algorithm comparable quality is obtained using helical cone-beam data with a normalized pitch of 10 to that obtained using standard spiral CT reconstruction with a normalized pitch of 2. PMID:10070801

  4. Cone-Beam Computed Tomography: Imaging Dose during CBCT Scan Acquisition and Accuracy of CBCT Based Dose Calculations

    NASA Astrophysics Data System (ADS)

    Giles, David Matthew

    Cone beam computed tomography (CBCT) is a recent development in radiotherapy for use in image guidance. Image guided radiotherapy using CBCT allows visualization of soft tissue targets and critical structures prior to treatment. Dose escalation is made possible by accurately localizing the target volume while reducing normal tissue toxicity. The kilovoltage x-rays of the cone beam imaging system contribute additional dose to the patient. In this study a 2D reference radiochromic film dosimetry method employing GAFCHROMIC(TM) model XR-QA film is used to measure point skin doses and dose profiles from the Elekta XVI CBCT system integrated onto the Synergy linac. The soft tissue contrast of the daily CBCT images makes adaptive radiotherapy possible in the clinic. In order to track dose to the patient or utilize on-line replanning for adaptive radiotherapy the CBCT images must be used to calculate dose. A Hounsfield unit calibration method for scatter correction is investigated for heterogeneity corrected dose calculation in CBCT images. Three Hounsfield unit to density calibration tables are used for each of four cases including patients and an anthropomorphic phantom, and the calculated dose from each is compared to results from the clinical standard fan beam CT. The dose from the scan acquisition is reported and the effect of scan geometry and total output of the x-ray tube on dose magnitude and distribution is shown. The ability to calculate dose with CBCT is shown to improve with the use of patient specific density tables for scatter correction, and for high beam energies the calculated dose agreement is within 1%.

  5. Evaluation of an in situ, on-line purging system for the cone penetrometer

    SciTech Connect

    Doskey, P.V.; Aldstadt, J.H.; Kuo, J.M.; Costanza, M.S.

    1996-11-01

    Materials that will be used to construct an in situ, on-line purging system for the cone penetrometer were evaluated. Transfer efficiencies for volatile organic compounds (VOCs) through stainless steel, nickel, aluminum, and Teflon tubings were determined using a gas-phase mixture of VOCs containing trichloromethane, tetrachloromethane, 1,1,1-trichloroethene, tetrachloroethene, hexane, benzene, toluene, and 1,2-dimethylbenzene. The water content of the gas stream had an insignificant effect on the quantitative transfer of VOCs through Teflon tubing but was critical to efficiently transfer the compounds through metal tubing, particularly nickel. Transfer efficiencies for all eight analytes in moist gas streams through stainless steel were greater than 95%. Toluene, tetrachloroethene, and 1,2-dimethybenzene were transferred with 93%, 81%, and 80% efficiency, respectively, when they were drawn through Teflon PFA (perfluoroalkoxy) tubing. In general, the retention of the VOCs by Teflon increases with decreasing aqueous solubility of the analyte. The efficiencies at which VOCs were purged from aqueous standards in Teflon PFA, Type 304 stainless steel, and glass vessels were similar. Stainless steel was superior to nickel, aluminum, and the Teflon polymers as a material for an in situ, on-line purging system for the cone penetrometer. 12 refs., 2 tabs.

  6. Measurement of breast tissue composition with dual energy cone-beam computed tomography: A postmortem study

    SciTech Connect

    Ding Huanjun; Ducote, Justin L.; Molloi, Sabee

    2013-06-15

    Purpose: To investigate the feasibility of a three-material compositional measurement of water, lipid, and protein content of breast tissue with dual kVp cone-beam computed tomography (CT) for diagnostic purposes. Methods: Simulations were performed on a flat panel-based computed tomography system with a dual kVp technique in order to guide the selection of experimental acquisition parameters. The expected errors induced by using the proposed calibration materials were also estimated by simulation. Twenty pairs of postmortem breast samples were imaged with a flat-panel based dual kVp cone-beam CT system, followed by image-based material decomposition using calibration data obtained from a three-material phantom consisting of water, vegetable oil, and polyoxymethylene plastic. The tissue samples were then chemically decomposed into their respective water, lipid, and protein contents after imaging to allow direct comparison with data from dual energy decomposition. Results: Guided by results from simulation, the beam energies for the dual kVp cone-beam CT system were selected to be 50 and 120 kVp with the mean glandular dose divided equally between each exposure. The simulation also suggested that the use of polyoxymethylene as the calibration material for the measurement of pure protein may introduce an error of -11.0%. However, the tissue decomposition experiments, which employed a calibration phantom made out of water, oil, and polyoxymethylene, exhibited strong correlation with data from the chemical analysis. The average root-mean-square percentage error for water, lipid, and protein contents was 3.58% as compared with chemical analysis. Conclusions: The results of this study suggest that the water, lipid, and protein contents can be accurately measured using dual kVp cone-beam CT. The tissue compositional information may improve the sensitivity and specificity for breast cancer diagnosis.

  7. Measurement of breast tissue composition with dual energy cone-beam computed tomography: A postmortem study

    PubMed Central

    Ding, Huanjun; Ducote, Justin L.; Molloi, Sabee

    2013-01-01

    Purpose: To investigate the feasibility of a three-material compositional measurement of water, lipid, and protein content of breast tissue with dual kVp cone-beam computed tomography (CT) for diagnostic purposes. Methods: Simulations were performed on a flat panel-based computed tomography system with a dual kVp technique in order to guide the selection of experimental acquisition parameters. The expected errors induced by using the proposed calibration materials were also estimated by simulation. Twenty pairs of postmortem breast samples were imaged with a flat-panel based dual kVp cone-beam CT system, followed by image-based material decomposition using calibration data obtained from a three-material phantom consisting of water, vegetable oil, and polyoxymethylene plastic. The tissue samples were then chemically decomposed into their respective water, lipid, and protein contents after imaging to allow direct comparison with data from dual energy decomposition. Results: Guided by results from simulation, the beam energies for the dual kVp cone-beam CT system were selected to be 50 and 120 kVp with the mean glandular dose divided equally between each exposure. The simulation also suggested that the use of polyoxymethylene as the calibration material for the measurement of pure protein may introduce an error of −11.0%. However, the tissue decomposition experiments, which employed a calibration phantom made out of water, oil, and polyoxymethylene, exhibited strong correlation with data from the chemical analysis. The average root-mean-square percentage error for water, lipid, and protein contents was 3.58% as compared with chemical analysis. Conclusions: The results of this study suggest that the water, lipid, and protein contents can be accurately measured using dual kVp cone-beam CT. The tissue compositional information may improve the sensitivity and specificity for breast cancer diagnosis. PMID:23718593

  8. Scatter correction, intermediate view estimation and dose characterization in megavoltage cone-beam CT imaging

    NASA Astrophysics Data System (ADS)

    Sramek, Benjamin Koerner

    The ability to deliver conformal dose distributions in radiation therapy through intensity modulation and the potential for tumor dose escalation to improve treatment outcome has necessitated an increase in localization accuracy of inter- and intra-fractional patient geometry. Megavoltage cone-beam CT imaging using the treatment beam and onboard electronic portal imaging device is one option currently being studied for implementation in image-guided radiation therapy. However, routine clinical use is predicated upon continued improvements in image quality and patient dose delivered during acquisition. The formal statement of hypothesis for this investigation was that the conformity of planned to delivered dose distributions in image-guided radiation therapy could be further enhanced through the application of kilovoltage scatter correction and intermediate view estimation techniques to megavoltage cone-beam CT imaging, and that normalized dose measurements could be acquired and inter-compared between multiple imaging geometries. The specific aims of this investigation were to: (1) incorporate the Feldkamp, Davis and Kress filtered backprojection algorithm into a program to reconstruct a voxelized linear attenuation coefficient dataset from a set of acquired megavoltage cone-beam CT projections, (2) characterize the effects on megavoltage cone-beam CT image quality resulting from the application of Intermediate View Interpolation and Intermediate View Reprojection techniques to limited-projection datasets, (3) incorporate the Scatter and Primary Estimation from Collimator Shadows (SPECS) algorithm into megavoltage cone-beam CT image reconstruction and determine the set of SPECS parameters which maximize image quality and quantitative accuracy, and (4) evaluate the normalized axial dose distributions received during megavoltage cone-beam CT image acquisition using radiochromic film and thermoluminescent dosimeter measurements in anthropomorphic pelvic and head and

  9. Comparative study of mandibular linear measurements obtained by cone beam computed tomography and digital calipers

    PubMed Central

    Tarazona-Álvarez, Pablo; Romero-Millán, Javier; Peñarrocha-Oltra, David; Fuster-Torres, María Á.; Tarazona, Beatriz

    2014-01-01

    Objectives: Cone beam computed tomography (CBCT) is an innovative dental of imaging system characterized by rapid volumetric imaging with patient exposure to a single dose of radiation. The present study was carried out to compare the linear measurements obtained with CBCT and digital caliper in 20 mandibles from human cadavers. Study design: A total of 4800 linear measurements were measured between different mandibular anatomical points with CBCT and digital caliper. The real measurements were defined as those obtained with the digital caliper. Posteriorly, the mandibles were scanned to obtain the CBCT images, with software-based measurements of the distances. Results: The measurements obtained with the digital caliper were greater. The CBCT technique underestimated distances greater than 100 mm. Conclusions: CBCT allows to obtain linear mandibular anatomical measurements equivalent to those obtained with digital caliper. The differences existing between both methods were clinically acceptable. Key words:Computed tomography, cone beam CT, accuracy, reliability, digital caliper. PMID:25136429

  10. Cone beam computed tomography and intraoral radiography for diagnosis of dental abnormalities in dogs and cats

    PubMed Central

    Silva, Luiz Antonio F.; Barriviera, Mauricio; Januário, Alessandro L.; Bezerra, Ana Cristina B.; Fioravanti, Maria Clorinda S.

    2011-01-01

    The development of veterinary dentistry has substantially improved the ability to diagnose canine and feline dental abnormalities. Consequently, examinations previously performed only on humans are now available for small animals, thus improving the diagnostic quality. This has increased the need for technical qualification of veterinary professionals and increased technological investments. This study evaluated the use of cone beam computed tomography and intraoral radiography as complementary exams for diagnosing dental abnormalities in dogs and cats. Cone beam computed tomography was provided faster image acquisition with high image quality, was associated with low ionizing radiation levels, enabled image editing, and reduced the exam duration. Our results showed that radiography was an effective method for dental radiographic examination with low cost and fast execution times, and can be performed during surgical procedures. PMID:22122905

  11. X-Ray cone-beam phase tomography formulas based on phase-attenuation duality.

    PubMed

    Wu, Xizeng; Liu, Hong

    2005-08-01

    We present a detailed derivation of the phase-retrieval formula based on the phase-attenuation duality that we recently proposed in previous brief communication. We have incorporated the effects of x-ray source coherence and detector resolution into the phase-retrieval formula as well. Since only a single image is needed for performing the phase retrieval by means of this new approach, we point out the great advantages of this new approach for implementation of phase tomography. We combine our phase-retrieval formula with the Feldkamp-Davis-Kresss (FDK) cone-beam reconstruction algorithm to provide a three-dimensional phase tomography formula for soft tissue objects of relatively small sizes, such as small animals or human breast. For large objects we briefly show how to apply Katsevich's cone-beam reconstruction formula to the helical phase tomography as well. PMID:19498608

  12. Cracked Tooth: A Report of Two Cases and Role of Cone Beam Computed Tomography in Diagnosis

    PubMed Central

    Kalyan Chakravarthy, Pishipati Vinayak; Telang, Lahari Ajay; Nerali, Jayashri; Telang, Ajay

    2012-01-01

    Cracked tooth is a distinct type of longitudinal tooth fracture which occurs very commonly and its diagnosis can be challenging. This type of fracture tends to grow and change over time. Clinical diagnosis is difficult because the signs and symptoms are variable or nonspecific and may even resemble post-treatment disease following root canal treatment or periodontal disease. This variety and unpredictability make the cracked tooth a challenging diagnostic entity. The use of cone beam computed tomography (CBCT) in diagnosis of complex endodontic cases has been well documented in the literature. In this paper we present two cases of cracked tooth and emphasise on the timely use of cone beam computed tomography as an aid in diagnosis and as a prognostic determinant. PMID:23198164

  13. Dental implants in bilateral bifid canal and compromised interocclusal space using cone beam computerized tomography.

    PubMed

    Ahmed, Nizar; Arunachalam, Lalitha Tanjore; Jacob, Caroline Annette; Kumar, Suresh Anand

    2016-01-01

    Knowledge of various anatomic landmarks is pivotal for important success. Bifid canals pose a challenge and can lead to difficulties while performing implant surgery in the mandible. Bifid canals can be diagnosed with panoramic radiography and more accurately with cone beam computerized tomography (CBCT). This case report details the placement of the implant in a patient with bilateral bifid canal and compromised interocclusal space, which was successfully treated using CBCT. PMID:27433073

  14. C-arm cone-beam computed tomography in interventional oncology: technical aspects and clinical applications

    PubMed Central

    Floridi, Chiara; Radaelli, Alessandro; Abi-Jaoudeh, Nadine; Grass, Micheal; Lin, Ming De; Chiaradia, Melanie; Geschwind, Jean-Francois; Kobeiter, Hishman; Squillaci, Ettore; Maleux, Geert; Giovagnoni, Andrea; Brunese, Luca; Wood, Bradford; Carrafiello, Gianpaolo; Rotondo, Antonio

    2014-01-01

    C-arm cone-beam computed tomography (CBCT) is a new imaging technology integrated in modern angiographic systems. Due to its ability to obtain cross-sectional imaging and the possibility to use dedicated planning and navigation software, it provides an informed platform for interventional oncology procedures. In this paper, we highlight the technical aspects and clinical applications of CBCT imaging and navigation in the most common loco-regional oncological treatments. PMID:25012472

  15. History of imaging in orthodontics from Broadbent to cone-beam computed tomography.

    PubMed

    Hans, Mark G; Palomo, J Martin; Valiathan, Manish

    2015-12-01

    The history of imaging and orthodontics is a story of technology informing biology. Advances in imaging changed our thinking as our understanding of craniofacial growth and the impact of orthodontic treatment deepened. This article traces the history of imaging in orthodontics from the invention of the cephalometer by B. Holly Broadbent in 1930 to the introduction of low-cost, low-radiation-dose cone-beam computed tomography imaging in 2015. PMID:26672697

  16. Evaluation of the Upper Airway Morphology: The Role of Cone Beam Computed Tomography.

    PubMed

    White, Susan M; Huang, Chien-Jung; Huang, Shao-Ching; Sun, Zhengzheng; Eldredge, Jeff D; Mallya, Sanjay M

    2015-09-01

    Cone beam computed tomography (CBCT) has several applications in dentomaxillofacial diagnosis. Frequently, the imaged volume encompasses the upper airway. This article provides a systematic approach to airway analysis and the implications of the anatomic and pathologic alterations. It discusses the role of CBCT in management of obstructive sleep apnea (OSA) patients. This paper also highlights technological advances that combine CBCT imaging with computational modeling of the airway and the potential clinical applications of such technologies. PMID:26820010

  17. Dental implants in bilateral bifid canal and compromised interocclusal space using cone beam computerized tomography

    PubMed Central

    Ahmed, Nizar; Arunachalam, Lalitha Tanjore; Jacob, Caroline Annette; Kumar, Suresh Anand

    2016-01-01

    Knowledge of various anatomic landmarks is pivotal for important success. Bifid canals pose a challenge and can lead to difficulties while performing implant surgery in the mandible. Bifid canals can be diagnosed with panoramic radiography and more accurately with cone beam computerized tomography (CBCT). This case report details the placement of the implant in a patient with bilateral bifid canal and compromised interocclusal space, which was successfully treated using CBCT. PMID:27433073

  18. Evidence and Professional Guidelines for Appropriate Use of Cone Beam Computed Tomography.

    PubMed

    Mallya, Sanjay M

    2015-09-01

    Cone beam computed tomography (CBCT) has applications in several aspects of dentistry. To appropriately use this technology, clinicians should be able to identify those situations where the information from CBCT is likely to provide useful information, and where this additional information translates into enhanced diagnoses, treatment plans and treatment outcomes. This article summarizes current evidence and recommendations from professional societies that guide safe and effective use of this technology for enhanced patient care. PMID:26820008

  19. Dental Cone-Beam Scans: Important Anatomic Views for the Contemporary Implant Surgeon.

    PubMed

    Greenstein, Gary; Carpentieri, Joseph R; Cavallaro, John

    2015-01-01

    Intraoral cone-beam computed tomography (CBCT), otherwise known as volume imaging CT scan, provides 3-dimensional images of mandibular and maxillary structures. These images offer highly accurate and valuable diagnostic information to facilitate treatment planning for implant cases. This article serves as a primer on how to read and interpret CBCT cross sectional views. It identifies anatomic structures of interest and discusses their clinical relevance. PMID:26625166

  20. The Applications of Cone-Beam Computed Tomography in Endodontics: A Review of Literature

    PubMed Central

    Kiarudi, Amir Hosein; Eghbal, Mohammad Jafar; Safi, Yaser; Aghdasi, Mohammad Mehdi; Fazlyab, Mahta

    2015-01-01

    By producing undistorted three-dimensional images of the area under examination, cone-beam computed tomography (CBCT) systems have met many of the limitations of conventional radiography. These systems produce images with small field of view at low radiation doses with adequate spatial resolution that are suitable for many applications in endodontics from diagnosis to treatment and follow-up. This review article comprehensively assembles all the data from literature regarding the potential applications of CBCT in endodontics. PMID:25598804

  1. Image reconstruction in circular cone-beam computed tomography by constrained, total-variation minimization

    PubMed Central

    Sidky, Emil Y.; Pan, Xiaochuan

    2009-01-01

    An iterative algorithm, based on recent work in compressive sensing, is developed for volume image reconstruction from a circular cone-beam scan. The algorithm minimizes the total-variation (TV) of the image subject to the constraint that the estimated projection data is within a specified tolerance of the available data and that the values of the volume image are non-negative. The constraints are enforced by use of projection onto convex sets (POCS) and the TV objective is minimized by steepest descent with an adaptive step-size. The algorithm is referred to as adaptive-steepest-descent-POCS (ASD-POCS). It appears to be robust against cone-beam artifacts, and may be particularly useful when the angular range is limited or when the angular sampling rate is low. The ASD-POCS algorithm is tested with the Defrise disk and jaw computerized phantoms. Some comparisons are performed with the POCS and expectation-maximization (EM) algorithms. Although the algorithm is presented in the context of circular cone-beam image reconstruction, it can also be applied to scanning geometries involving other x-ray source trajectories. PMID:18701771

  2. X-ray cone-beam computed tomography: principles, applications, challenges and solutions

    NASA Astrophysics Data System (ADS)

    Noo, Frederic

    2010-03-01

    In the nineties, x-ray computed tomography, commonly referred to as CT, seemed to be on the track to become old technology, bound to be replaced by more sophisticated techniques such as magnetic resonance imaging, due in particular to the harmful effects of x-ray radiation exposure. Yet, the new century brought with it new technology that allowed a complete change in trends and re-affirmed CT as an essential tool in radiology. For instance, the popularity of CT in 2007 was such that approximately 68.7 million CT examinations were performed in the United States, which was nearly 2.5 times the number of magnetic resonance (MRI) examinations. More than that, CT has expanded beyond its conventional diagnostic role; CT is now used routinely in interventional radiology and also in radiation therapy treatment. The technology advances that allowed the revival of CT are those that made fast, accurate cone-beam data acquisition possible. Nowadays, cone-beam data acquisition allows scanning large volumes with isotropic sub-millimeter spatial resolution in a very fast time, which can be as short as 500ms for cardiac imaging. The principles of cone-beam imaging will be first reviewed. Then a discussion of its applications will be given. Old and new challenges will be presented along the way with current solutions.

  3. Region-of-interest reconstruction for a cone-beam dental CT with a circular trajectory

    NASA Astrophysics Data System (ADS)

    Hu, Zhanli; Zou, Jing; Gui, Jianbao; Zheng, Hairong; Xia, Dan

    2013-04-01

    Dental CT is the most appropriate and accurate device for preoperative evaluation of dental implantation. It can demonstrate the quantity of bone in three dimensions (3D), the location of important adjacent anatomic structures and the quality of available bone with minimal geometric distortion. Nevertheless, with the rapid increase of dental CT examinations, we are facing the problem of dose reduction without loss of image quality. In this work, backprojection-filtration (BPF) and Feldkamp-Davis-Kress (FDK) algorithm was applied to reconstruct the 3D full image and region-of-interest (ROI) image from complete and truncated circular cone-beam data respectively by computer-simulation. In addition, the BPF algorithm was evaluated based on the 3D ROI-image reconstruction from real data, which was acquired from our developed circular cone-beam prototype dental CT system. The results demonstrated that the ROI-image quality reconstructed from truncated data using the BPF algorithm was comparable to that reconstructed from complete data. The FDK algorithm, however, created artifacts while reconstructing ROI-image. Thus it can be seen, for circular cone-beam dental CT, reducing scanning angular range of the BPF algorithm used for ROI-image reconstruction are helpful for reducing the radiation dose and scanning time. Finally, an analytical method was developed for estimation of the ROI projection area on the detector before CT scanning, which would help doctors to roughly estimate the total radiation dose before the CT examination.

  4. Exact Reconstruction From Uniformly Attenuated Helical Cone-Beam Projections in SPECT

    SciTech Connect

    Gullberg, Grant T; Huang, Qiu; You, Jiangsheng; Zeng, Gengsheng L.

    2008-12-18

    In recent years the development of cone-beam reconstruction algorithms has been an active research area in x-ray computed tomography (CT), and significant progress has been made in the advancement of algorithms. Theoretically exact and computationally efficient analytical algorithms can be found in the literature. However, in single photon emission computed tomography (SPECT), published cone-beam reconstruction algorithms are either approximate or involve iterative methods. The SPECT reconstruction problem is more complicated due to degradations in the imaging detection process, one of which is the effect of attenuation of gamma ray photons. Attenuation should be compensated for to obtain quantitative results. In this paper, an analytical reconstruction algorithm for uniformly attenuated cone-beam projection data is presented for SPECT imaging. The algorithm adopts the DBH method, a procedure consisting of differentiation and backprojection followed by a finite inverse cosh-weighted Hilbert transform. The significance of the proposed approach is that a selected region of interest can be reconstructed even with a detector with a reduced field of view. The algorithm is designed for a general trajectory. However, to validate the algorithm, a numerical study was performed using a helical trajectory. The implementation is efficient and the simulation result is promising.

  5. Virtual alignment of x-ray cone-beam tomography system using two calibration aperture measurements

    NASA Astrophysics Data System (ADS)

    Bronnikov, Andrei V.

    1999-02-01

    In cone-beam tomography, relatively small misalignment of the imaging system is geometrically magnified and may cause severe distortion of the reconstructed image. We describe a method for alignment of a cone-beam tomography system built on an x-ray microfocus tube, an image intensifier, and a high-resolution CCD camera. To obtain geometrical parameters of system misalignment, we suggest measuring two 180-deg- opposed cone-beam radiographs of a specially manufactured calibration aperture. An advantage of the aperture over other calibration objects is that we can easily restore its idealized picture by applying a certain threshold to the measured data. The method permits the lateral displacement vector and lateral tilt angle to be accurately found. Unlike other alignment methods, our approach enables virtual system alignment by using mathematical processing of the measured data, rather than moving the parts of the system. The virtually aligned system data are used for 3D image reconstruction by a standard filtered backprojection algorithm. Experimental results demonstrate considerable improvement of the image quality after applying the alignment method suggested.

  6. Estimation of organ and effective doses resulting from cone beam CT imaging for radiotherapy treatment planning.

    PubMed

    Sawyer, L J; Whittle, S A; Matthews, E S; Starritt, H C; Jupp, T P

    2009-07-01

    In this study, organ doses were measured for various kilovoltage cone beam CT exposures on the Varian Acuity simulator and an alternative method of dose estimation was also assessed. Organ doses were measured by distributing thermoluminescent dosimeters (TLDs) throughout an anthropomorphic phantom, and effective doses were calculated using International Commission on Radiological Protection (ICRP) 60 and ICRP 103 tissue-weighting factors. The ImPACT CT patient dosimetry calculator was also used to estimate doses for comparison with the TLD results. Effective doses of 15.3 mSv (19.4 mSv), 14.3 mSv (9.7 mSv) and 2.8 mSv (3.2 mSv) were calculated from the TLD measurements and ICRP 60 (ICRP 103) weighting factors for breast, pelvis and head acquisitions, respectively. When a 10 cm pencil ionisation chamber was used to measure the CT dose index, the ImPACT calculator was found to provide an adequate estimation of dose when compared with the TLD results. However, the doses for half-fan exposures were found to be overestimated, with the extent of overestimation depending on the radiosensitive organs irradiated. The organ and effective doses reported provide information for justification and optimisation of cone beam CT procedures, and are compared with doses delivered by other imaging devices. The ImPACT calculator may be used to estimate doses from cone beam CT procedures, if the potential for overestimation is acknowledged. PMID:19255115

  7. A new method to combine 3D reconstruction volumes for multiple parallel circular cone beam orbits

    PubMed Central

    Baek, Jongduk; Pelc, Norbert J.

    2010-01-01

    Purpose: This article presents a new reconstruction method for 3D imaging using a multiple 360° circular orbit cone beam CT system, specifically a way to combine 3D volumes reconstructed with each orbit. The main goal is to improve the noise performance in the combined image while avoiding cone beam artifacts. Methods: The cone beam projection data of each orbit are reconstructed using the FDK algorithm. When at least a portion of the total volume can be reconstructed by more than one source, the proposed combination method combines these overlap regions using weighted averaging in frequency space. The local exactness and the noise performance of the combination method were tested with computer simulations of a Defrise phantom, a FORBILD head phantom, and uniform noise in the raw data. Results: A noiseless simulation showed that the local exactness of the reconstructed volume from the source with the smallest tilt angle was preserved in the combined image. A noise simulation demonstrated that the combination method improved the noise performance compared to a single orbit reconstruction. Conclusions: In CT systems which have overlap volumes that can be reconstructed with data from more than one orbit and in which the spatial frequency content of each reconstruction can be calculated, the proposed method offers improved noise performance while keeping the local exactness of data from the source with the smallest tilt angle. PMID:21089770

  8. CoBRA: Cone beam Computed Tomography (CT) reconstruction code in Interactive Data Language (IDL)

    SciTech Connect

    Sheats, M.J.; Stupin, D.M.

    1997-10-01

    In support of stockpile stewardship and other important missions, Los Alamos is continually looking for fast and effective ways of inspecting and evaluating industrial parts. Thus, Los Alamos is continually striving to improve our radiography and computed tomography (CT) capabilities. Cormack and Hounsfield received the Nobel Prize in 1979 for their pioneering work in computed tomography that led to the development of medical scanners. Copley et al. provides a good history of the development of industrial CT systems. The early systems collect data via a single detector or linear detector array. While CT offers greatly increased spatial resolutions over radiography, CT inspections with a linear array are slow and costly. To improve the viability of CT for NDT applications, Feldkamp, Davis, and Kress reported a cone beam reconstruction technique that speeds up the CT process by using image data rather than data collected by a linear array. Because it potentially offers processing speeds up to 10 times faster than CT systems that use a linear array, we are building a cone beam CT for use with our 20 MV x-ray source and Los Alamos Neutron Science Center (LANSCE) neutron sources. Our software, called CoBRA, is a portable cone beam reconstruction code for CT applications that efficiently and rapidly reconstructs large data sets. CoBRA applications include both x-ray and neutron inspections using x-ray phosphor screens coupled to either a CCD camera or flat-panel amorphous silicon arrays. Photographs of two amorphous silicon arrays.

  9. Comparison of two detector systems for cone beam CT small animal imaging - a preliminary study

    PubMed Central

    Meng, Yang; Shaw, Chris C.; Liu, Xinming; Altunbas, Mustafa C.; Wang, Tianpeng; Chen, Lingyun; Tu, Shu-Ju; Kappadath, S. Cheenu; Lai, Chao-Jen

    2007-01-01

    Purpose To compare two detector systems - one based on the charge-coupled device (CCD) and image amplifier, the other based on a-Si/CsI flat panel, for cone beam computed-tomography (CT) imaging of small animals. A high resolution, high framing rate detector system for the cone beam CT imaging of small animals was developed. The system consists of a 2048×3072×12 bit CCD optically coupled to an image amplifier and an x-ray phosphor screen. The CCD has an intrinsic pixel size of 12 μm but the effective pixel size can be adjusted through the magnification adjustment of the optical coupling systems. The system is used in conjunction with an x-ray source and a rotating stage for holding and rotating the scanned object in the cone beam CT imaging experiments. The advantages of the system include but are not limited to the ability to adjust the effective pixel size and to achieve extremely high spatial resolution and temporal resolution. However, the need to use optical coupling compromises the detective quanta efficiency (DQE) of the system. In this paper, the imaging characteristics of the system were presented and compared with those of an a-Si/CsI flat-panel detector system. PMID:18160972

  10. Marker-free lung tumor trajectory estimation from a cone beam CT sinogram

    NASA Astrophysics Data System (ADS)

    Hugo, Geoffrey D.; Liang, Jian; Yan, Di

    2010-05-01

    An algorithm was developed to estimate the 3D lung tumor position using the projection data forming a cone beam CT sinogram and a template registration method. A pre-existing respiration-correlated CT image was used to generate templates of the target, which were then registered to the individual cone beam CT projections, and estimates of the target position were made for each projection. The registration search region was constrained based on knowledge of the mean tumor position during the cone beam CT scan acquisition. Several template registration algorithms were compared, including correlation coefficient and robust methods such as block correlation, robust correlation coefficient and robust gradient correlation. Robust registration metrics were found to be less sensitive to occlusions such as overlying tissue and the treatment couch. The mean accuracy of the position estimation was 1.4 mm in phantom with a robust registration algorithm. In two research subjects with peripheral tumors, the mean position and mean target excursion were estimated to within 2.0 mm compared to the results obtained with a '4D' registration of 4D image volumes.

  11. The adaptation of megavoltage cone beam CT for use in standard radiotherapy treatment planning

    NASA Astrophysics Data System (ADS)

    Thomas, T. Hannah Mary; Devakumar, D.; Purnima, S.; Ravindran, B. Paul

    2009-04-01

    Potential areas where megavoltage computed tomography (MVCT) could be used are second- and third-phase treatment planning in 3D conformal radiotherapy and IMRT, adaptive radiation therapy, single fraction palliative treatment and for the treatment of patients with metal prostheses. A feasibility study was done on using MV cone beam CT (CBCT) images generated by proprietary 3D reconstruction software based on the FDK algorithm for megavoltage treatment planning. The reconstructed images were converted to a DICOM file set. The pixel values of megavoltage cone beam computed tomography (MV CBCT) were rescaled to those of kV CT for use with a treatment planning system. A calibration phantom was designed and developed for verification of geometric accuracy and CT number calibration. The distance measured between two marker points on the CBCT image and the physical dimension on the phantom were in good agreement. Point dose verification for a 10 cm × 10 cm beam at a gantry angle of 0° and SAD of 100 cm were performed for a 6 MV beam for both kV and MV CBCT images. The point doses were found to vary between ±6.1% of the dose calculated from the kV CT image. The isodose curves for 6 MV for both kV CT and MV CBCT images were within 2% and 3 mm distance-to-agreement. A plan with three beams was performed on MV CBCT, simulating a treatment plan for cancer of the pituitary. The distribution obtained was compared with those corresponding to that obtained using the kV CT. This study has shown that treatment planning with MV cone beam CT images is feasible.

  12. The adaptation of megavoltage cone beam CT for use in standard radiotherapy treatment planning.

    PubMed

    Thomas, T Hannah Mary; Devakumar, D; Purnima, S; Ravindran, B Paul

    2009-04-01

    Potential areas where megavoltage computed tomography (MVCT) could be used are second- and third-phase treatment planning in 3D conformal radiotherapy and IMRT, adaptive radiation therapy, single fraction palliative treatment and for the treatment of patients with metal prostheses. A feasibility study was done on using MV cone beam CT (CBCT) images generated by proprietary 3D reconstruction software based on the FDK algorithm for megavoltage treatment planning. The reconstructed images were converted to a DICOM file set. The pixel values of megavoltage cone beam computed tomography (MV CBCT) were rescaled to those of kV CT for use with a treatment planning system. A calibration phantom was designed and developed for verification of geometric accuracy and CT number calibration. The distance measured between two marker points on the CBCT image and the physical dimension on the phantom were in good agreement. Point dose verification for a 10 cm x 10 cm beam at a gantry angle of 0 degrees and SAD of 100 cm were performed for a 6 MV beam for both kV and MV CBCT images. The point doses were found to vary between +/-6.1% of the dose calculated from the kV CT image. The isodose curves for 6 MV for both kV CT and MV CBCT images were within 2% and 3 mm distance-to-agreement. A plan with three beams was performed on MV CBCT, simulating a treatment plan for cancer of the pituitary. The distribution obtained was compared with those corresponding to that obtained using the kV CT. This study has shown that treatment planning with MV cone beam CT images is feasible. PMID:19287087

  13. Current role of hybrid CT/angiography system compared with C-arm cone beam CT for interventional oncology

    PubMed Central

    Arai, Y; Inaba, Y; Inoue, M; Nishiofuku, H; Anai, H; Hori, S; Sakaguchi, H; Kichikawa, K

    2014-01-01

    Hybrid CT/angiography (angiography) system and C-arm cone beam CT provide cross-sectional imaging as an adjunct to angiography. Current interventional oncological procedures can be conducted precisely using these two technologies. In this article, several cases using a hybrid CT/angiography system are shown first, and then the advantages and disadvantages of the hybrid CT/angiography and C-arm cone beam CT are discussed with literature reviews. PMID:24968749

  14. Technical Note: Suppression of artifacts arising from simultaneous cone-beam imaging and RF transponder tracking in prostate radiotherapy

    SciTech Connect

    Poludniowski, Gavin; Webb, Steve; Evans, Philip M.

    2012-03-15

    Purpose: Artifacts in treatment-room cone-beam reconstructions have been observed at the authors' center when cone-beam acquisition is simultaneous with radio frequency (RF) transponder tracking using the Calypso 4D system (Calypso Medical, Seattle, WA). These artifacts manifest as CT-number modulations and increased CT-noise. The authors present a method for the suppression of the artifacts. Methods: The authors propose a three-stage postprocessing technique that can be applied to image volumes previously reconstructed by a cone-beam system. The stages are (1) segmentation of voxels into air, soft-tissue, and bone; (2) application of a 2D spatial-filter in the axial plane to the soft-tissue voxels; and (3) normalization to remove streaking along the axial-direction. The algorithm was tested on patient data acquired with Synergy XVI cone-beam CT systems (Elekta, Crawley, United Kingdom). Results: The computational demands of the suggested correction are small, taking less than 15 s per cone-beam reconstruction on a desktop PC. For a moderate loss of spatial-resolution, the artifacts are strongly suppressed and low-contrast visibility is improved. Conclusions: The correction technique proposed is fast and effective in removing the artifacts caused by simultaneous cone-beam imaging and RF-transponder tracking.

  15. SU-E-J-99: Reconstruction of Cone Beam CT Image Using Volumetric Modulated Arc Therapy Exit Beams

    SciTech Connect

    Jeong, K; Goddard, L; Savacool, M; Mynampati, D; Godoy Scripes, P; Tome', W; Kuo, H; Basavatia, A; Hong, L; Yaparpalvi, R; Kalnicki, S

    2014-06-01

    Purpose: To test the possibility of obtaining an image of the treated volume during volumetric modulated arc therapy (VMAT) with exit beams. Method: Using a Varian Clinac 21EX and MVCT detector the following three sets of detector projection data were obtained for cone beam CT reconstruction with and without a Catphan 504 phantom. 1) 72 projection images from 20 × 16 cm{sup 2} open beam with 3 MUs, 2) 72 projection images from 20 × 16 cm{sup 2} MLC closed beam with 14 MUs. 3) 137 projection images from a test RapicArc QA plan. All projection images were obtained in ‘integrated image’ mode. We used OSCaR code to reconstruct the cone beam CT images. No attempts were made to reduce scatter or artifacts. Results: With projection set 1) we obtained a good quality MV CBCT image by optimizing the reconstruction parameters. Using projection set 2) we were not able to obtain a CBCT image of the phantom, which was determined to be due to the variation of interleaf leakage with gantry angle. From projection set 3), we were able to obtain a weak but meaningful signal in the image, especially in the target area where open beam signals were dominant. This finding suggests that one might be able to acquire CBCT images with rough body shape and some details inside the irradiated target area. Conclusion: Obtaining patient images using the VMAT exit beam is challenging but possible. We were able to determine sources of image degradation such as gantry angle dependent interleaf leakage and beams with a large scatter component. We are actively working on improving image quality.

  16. Modeling the measurement of ultrasonic beams transmitted through a penetrable acoustic cone.

    PubMed

    Huthwaite, Peter; Simonetti, Francesco

    2012-10-01

    The interaction of ultrasonic beams with conical scatterers is governed by a combination of diffraction effects occurring at the aperture of the acoustic source/receiver and refraction through the cone. Accordingly, the outcome of a transmission experiment is dependent upon the many physical parameters characterizing the transducers and the cone. We develop a simplified model which describes the deflection caused by refraction through the cone using ray theory, then uses Huygens' summation to calculate the transducer response from this deflection. The model's accuracy is verified by comparison to simulated data. The model shows that transmission occurs in two different regimes, depending on the parameters of the particular problem. In the first regime, the cone alters the spatial phase distribution of the incident field along the receiver's aperture, whereas its amplitude remains almost unchanged. Because the receiver integrates the field over the aperture, the phasing affects the measurements via constructive and destructive interference. In the second regime, the phase alteration is accompanied by large amplitude variations around an average value that is significantly smaller than the amplitude observed in the first regime. The approximation will aid the design of ultrasound tomography arrays, such as those being developed for breast cancer detection. PMID:23143578

  17. Accurate technique for complete geometric calibration of cone-beam computed tomography systems.

    PubMed

    Cho, Youngbin; Moseley, Douglas J; Siewerdsen, Jeffrey H; Jaffray, David A

    2005-04-01

    Cone-beam computed tomography systems have been developed to provide in situ imaging for the purpose of guiding radiation therapy. Clinical systems have been constructed using this approach, a clinical linear accelerator (Elekta Synergy RP) and an iso-centric C-arm. Geometric calibration involves the estimation of a set of parameters that describes the geometry of such systems, and is essential for accurate image reconstruction. We have developed a general analytic algorithm and corresponding calibration phantom for estimating these geometric parameters in cone-beam computed tomography (CT) systems. The performance of the calibration algorithm is evaluated and its application is discussed. The algorithm makes use of a calibration phantom to estimate the geometric parameters of the system. The phantom consists of 24 steel ball bearings (BBs) in a known geometry. Twelve BBs are spaced evenly at 30 deg in two plane-parallel circles separated by a given distance along the tube axis. The detector (e.g., a flat panel detector) is assumed to have no spatial distortion. The method estimates geometric parameters including the position of the x-ray source, position, and rotation of the detector, and gantry angle, and can describe complex source-detector trajectories. The accuracy and sensitivity of the calibration algorithm was analyzed. The calibration algorithm estimates geometric parameters in a high level of accuracy such that the quality of CT reconstruction is not degraded by the error of estimation. Sensitivity analysis shows uncertainty of 0.01 degrees (around beam direction) to 0.3 degrees (normal to the beam direction) in rotation, and 0.2 mm (orthogonal to the beam direction) to 4.9 mm (beam direction) in position for the medical linear accelerator geometry. Experimental measurements using a laboratory bench Cone-beam CT system of known geometry demonstrate the sensitivity of the method in detecting small changes in the imaging geometry with an uncertainty of 0

  18. An index of beam hardening artifact for two-dimensional cone-beam CT tomographic images: establishment and preliminary evaluation

    NASA Astrophysics Data System (ADS)

    Yuan, Fusong; Lv, Peijun; Yang, Huifang; Wang, Yong; Sun, Yuchun

    2015-07-01

    Objectives: Based on the pixel gray value measurements, establish a beam-hardening artifacts index of the cone-beam CT tomographic image, and preliminarily evaluate its applicability. Methods: The 5mm-diameter metal ball and resin ball were fixed on the light-cured resin base plate respectively, while four vitro molars were fixed above and below the ball, on the left and right respectively, which have 10mm distance with the metal ball. Then, cone beam CT was used to scan the fixed base plate twice. The same layer tomographic images were selected from the two data and imported into the Photoshop software. The circle boundary was built through the determination of the center and radius of the circle, according to the artifact-free images section. Grayscale measurement tools were used to measure the internal boundary gray value G0, gray value G1 and G2 of 1mm and 20mm artifacts outside the circular boundary, the length L1 of the arc with artifacts in the circular boundary, the circumference L2. Hardening artifacts index was set A = (G1 / G0) * 0.5 + (G2 / G1) * 0.4 + (L2 / L1) * 0.1. Then, the A values of metal and resin materials were calculated respectively. Results: The A value of cobalt-chromium alloy material is 1, and resin material is 0. Conclusion: The A value reflects comprehensively the three factors of hardening artifacts influencing normal oral tissue image sharpness of cone beam CT. The three factors include relative gray value, the decay rate and range of artifacts.

  19. Effects of the irradiation of a finite number of laser beams on the implosion of a cone-guided target

    NASA Astrophysics Data System (ADS)

    Yanagawa, T.; Sakagami, H.; Nagatomo, H.; Sunahara, A.

    2016-03-01

    In direct drive laser fusion, the non-uniformity of the laser absorption on the target surface caused by the irradiation of a finite number of laser beams is a sever problem. GekkoXII laser at Osaka University has twelve laser beams and is irradiated to the target with a dodecahedron orientation, in which the distribution of the laser absorption on the target surface becomes non-uniform. Furthermore, in the case of a cone-guided target, the laser irradiation orientation is more limited. In this paper, we conducted implosion simulations of the cone- guided target based on GekkoXII irradiation orientation and compared the case of using the twelve beams and nine beams where the three beams irradiating the cone region are cut. The implosion simulations were conducted by a three-dimensional pure hydro code.

  20. 3D In Vivo Dosimetry Using Megavoltage Cone-Beam CT and EPID Dosimetry

    SciTech Connect

    Elmpt, Wouter van Nijsten, Sebastiaan; Petit, Steven; Mijnheer, Ben; Lambin, Philippe; Dekker, Andre

    2009-04-01

    Purpose: To develop a method that reconstructs, independently of previous (planning) information, the dose delivered to patients by combining in-room imaging with transit dose measurements during treatment. Methods and Materials: A megavoltage cone-beam CT scan of the patient anatomy was acquired with the patient in treatment position. During treatment, delivered fields were measured behind the patient with an electronic portal imaging device. The dose information in these images was back-projected through the cone-beam CT scan and used for Monte Carlo simulation of the dose distribution inside the cone-beam CT scan. Validation was performed using various phantoms for conformal and IMRT plans. Clinical applicability is shown for a head-and-neck cancer patient treated with IMRT. Results: For single IMRT beams and a seven-field IMRT step-and-shoot plan, the dose distribution was reconstructed within 3%/3mm compared with the measured or planned dose. A three-dimensional conformal plan, verified using eight point-dose measurements, resulted in a difference of 1.3 {+-} 3.3% (1 SD) compared with the reconstructed dose. For the patient case, planned and reconstructed dose distribution was within 3%/3mm for about 95% of the points within the 20% isodose line. Reconstructed mean dose values, obtained from dose-volume histograms, were within 3% of prescribed values for target volumes and normal tissues. Conclusions: We present a new method that verifies the dose delivered to a patient by combining in-room imaging with the transit dose measured during treatment. This verification procedure opens possibilities for offline adaptive radiotherapy and dose-guided radiotherapy strategies taking into account the dose distribution delivered during treatment sessions.

  1. Direct determination of geometric alignment parameters for cone-beam scanners.

    PubMed

    Mennessier, C; Clackdoyle, R; Noo, F

    2009-03-21

    This paper describes a comprehensive method for determining the geometric alignment parameters for cone-beam scanners (often called calibrating the scanners or performing geometric calibration). The method is applicable to x-ray scanners using area detectors, or to SPECT systems using pinholes or cone-beam converging collimators. Images of an alignment test object (calibration phantom) fixed in the field of view of the scanner are processed to determine the nine geometric parameters for each view. The parameter values are found directly using formulae applied to the projected positions of the test object marker points onto the detector. Each view is treated independently, and no restrictions are made on the position of the cone vertex, or on the position or orientation of the detector. The proposed test object consists of 14 small point-like objects arranged with four points on each of three orthogonal lines, and two points on a diagonal line. This test object is shown to provide unique solutions for all possible scanner geometries, even when partial measurement information is lost by points superimposing in the calibration scan. For the many situations where the cone vertex stays reasonably close to a central plane (for circular, planar, or near-planar trajectories), a simpler version of the test object is appropriate. The simpler object consists of six points, two per orthogonal line, but with some restrictions on the positioning of the test object. This paper focuses on the principles and mathematical justifications for the method. Numerical simulations of the calibration process and reconstructions using estimated parameters are also presented to validate the method and to provide evidence of the robustness of the technique. PMID:19242049

  2. Direct determination of geometric alignment parameters for cone-beam scanners

    PubMed Central

    Mennessier, C; Clackdoyle, R; Noo, F

    2009-01-01

    This paper describes a comprehensive method for determining the geometric alignment parameters for cone-beam scanners (often called calibrating the scanners or performing geometric calibration). The method is applicable to x-ray scanners using area detectors, or to SPECT systems using pinholes or cone-beam converging collimators. Images of an alignment test object (calibration phantom) fixed in the field of view of the scanner are processed to determine the nine geometric parameters for each view. The parameter values are found directly using formulae applied to the projected positions of the test object marker points onto the detector. Each view is treated independently, and no restrictions are made on the position of the cone vertex, or on the position or orientation of the detector. The proposed test object consists of 14 small point-like objects arranged with four points on each of three orthogonal lines, and two points on a diagonal line. This test object is shown to provide unique solutions for all possible scanner geometries, even when partial measurement information is lost by points superimposing in the calibration scan. For the many situations where the cone vertex stays reasonably close to a central plane (for circular, planar, or near-planar trajectories), a simpler version of the test object is appropriate. The simpler object consists of six points, two per orthogonal line, but with some restrictions on the positioning of the test object. This paper focuses on the principles and mathematical justifications for the method. Numerical simulations of the calibration process and reconstructions using estimated parameters are also presented to validate the method and to provide evidence of the robustness of the technique. PMID:19242049

  3. Modulation transfer function determination using the edge technique for cone-beam micro-CT

    NASA Astrophysics Data System (ADS)

    Rong, Junyan; Liu, Wenlei; Gao, Peng; Liao, Qimei; Lu, Hongbing

    2016-03-01

    Evaluating spatial resolution is an essential work for cone-beam computed tomography (CBCT) manufacturers, prototype designers or equipment users. To investigate the cross-sectional spatial resolution for different transaxial slices with CBCT, the slanted edge technique with a 3D slanted edge phantom are proposed and implemented on a prototype cone-beam micro-CT. Three transaxial slices with different cone angles are under investigation. An over-sampled edge response function (ERF) is firstly generated from the intensity of the slightly tiled air to plastic edge in each row of the transaxial reconstruction image. Then the oversampled ESF is binned and smoothed. The derivative of the binned and smoothed ERF gives the line spread function (LSF). At last the presampled modulation transfer function (MTF) is calculated by taking the modulus of the Fourier transform of the LSF. The spatial resolution is quantified with the spatial frequencies at 10% MTF level and full-width-half-maximum (FWHM) value. The spatial frequencies at 10% of MTFs are 3.1+/-0.08mm-1, 3.0+/-0.05mm-1, and 3.2+/-0.04mm-1 for the three transaxial slices at cone angles of 3.8°, 0°, and -3.8° respectively. The corresponding FWHMs are 252.8μm, 261.7μm and 253.6μm. Results indicate that cross-sectional spatial resolution has no much differences when transaxial slices being 3.8° away from z=0 plane for the prototype conebeam micro-CT.

  4. Characteristics of kilovoltage x-ray beams used for cone-beam computed tomography in radiation therapy

    NASA Astrophysics Data System (ADS)

    Ding, George X.; Duggan, Dennis M.; Coffey, Charles W.

    2007-03-01

    The purpose of this investigation is to characterize the beams produced by a kilovoltage (kV) imager integrated into a linear accelerator (Varian on-board imager integrated into the Trilogy accelerator) for acquiring high resolution volumetric cone-beam computed tomography (CBCT) images of the patient on the treatment table. The x-ray tube is capable of generating photon spectra with kVp values between 40 and 125 kV. The Monte Carlo simulations were used to study the characteristics of kV beams and the properties of imaged target scatters. The Monte Carlo results were benchmarked against measurements, and excellent agreements were obtained. We also studied the effect of including the electron impact ionization (EII), and the simulation showed that the characteristic radiation is increased significantly in the energy spectra when EII is included. Although only slight beam hardening is observed in the spectra of all photons after passing through the phantom target, there is a significant difference in the spectra and angular distributions between scattered and primary photons. The results also show that the photon fluence distributions are significantly altered by adding bow tie filters. The results indicate that a combination of large cone-beam field size and large imaged target significantly increases scatter-to-primary ratios for photons that reach the detector panel. For phantoms 10 cm, 20 cm and 30 cm thick of water placed at the isocentre, the scatter-to-primary ratios are 0.94, 3.0 and 7.6 respectively for an open 125 kVp CBCT beam. The Monte Carlo simulations show that the increase of the scatter is proportional to the increase of the imaged volume, and this also applies to scatter-to-primary ratios. This study shows both the magnitude and the characteristics of scattered x-rays. The knowledge obtained from this investigation may be useful in the future design of the image detector to improve the image quality.

  5. Scattering-compensated cone beam x-ray luminescence computed tomography

    NASA Astrophysics Data System (ADS)

    Gao, Peng; Rong, Junyan; Pu, Huangsheng; Liu, Wenlei; Liao, Qimei; Lu, Hongbing

    2016-04-01

    X-ray luminescence computed tomography (XLCT) opens new possibilities to perform molecular imaging with x-ray. It is a dual modality imaging technique based on the principle that some nanophosphors can emit near-infrared (NIR) light when excited by x-rays. The x-ray scattering effect is a great issue in both CT and XLCT reconstruction. It has been shown that if the scattering effect compensated, the reconstruction average relative error can be reduced from 40% to 12% in the in the pencil beam XLCT. However, the scattering effect in the cone beam XLCT has not been proved. To verify and reduce the scattering effect, we proposed scattering-compensated cone beam x-ray luminescence computed tomography using an added leading to prevent the spare x-ray outside the irradiated phantom in order to decrease the scattering effect. Phantom experiments of two tubes filled with Y2O3:Eu3+ indicated that the proposed method could reduce the scattering by a degree of 30% and can reduce the location error from 1.8mm to 1.2mm. Hence, the proposed method was feasible to the general case and actual experiments and it is easy to implement.

  6. Comparative study of a low-Z cone-beam computed tomography system

    NASA Astrophysics Data System (ADS)

    Roberts, D. A.; Hansen, V. N.; Thompson, M. G.; Poludniowski, G.; Niven, A.; Seco, J.; Evans, P. M.

    2011-07-01

    Computed tomography images have been acquired using an experimental (low atomic number (Z) insert) megavoltage cone-beam imaging system. These images have been compared with standard megavoltage and kilovoltage imaging systems. The experimental system requires a simple modification to the 4 MeV electron beam from an Elekta Precise linac. Low-energy photons are produced in the standard medium-Z electron window and a low-Z carbon electron absorber located after the window. The carbon electron absorber produces photons as well as ensuring that all remaining electrons from the source are removed. A detector sensitive to diagnostic x-ray energies is also employed. Quantitative assessment of cone-beam computed tomography (CBCT) contrast shows that the low-Z imaging system is an order of magnitude or more superior to a standard 6 MV imaging system. CBCT data with the same contrast-to-noise ratio as a kilovoltage imaging system (0.15 cGy) can be obtained in doses of 11 and 244 cGy for the experimental and standard 6 MV systems, respectively. Whilst these doses are high for everyday imaging, qualitative images indicate that kilovoltage like images suitable for patient positioning can be acquired in radiation doses of 1-8 cGy with the experimental low-Z system.

  7. WE-G-18A-06: Sinogram Restoration in Helical Cone-Beam CT

    SciTech Connect

    Little, K; Riviere, P La

    2014-06-15

    Purpose: To extend CT sinogram restoration, which has been shown in 2D to reduce noise and to correct for geometric effects and other degradations at a low computational cost, from 2D to a 3D helical cone-beam geometry. Methods: A method for calculating sinogram degradation coefficients for a helical cone-beam geometry was proposed. These values were used to perform penalized-likelihood sinogram restoration on simulated data that were generated from the FORBILD thorax phantom. Sinogram restorations were performed using both a quadratic penalty and the edge-preserving Huber penalty. After sinogram restoration, Fourier-based analytical methods were used to obtain reconstructions. Resolution-variance trade-offs were investigated for several locations within the reconstructions for the purpose of comparing sinogram restoration to no restoration. In order to compare potential differences, reconstructions were performed using different groups of neighbors in the penalty, two analytical reconstruction methods (Katsevich and single-slice rebinning), and differing helical pitches. Results: The resolution-variance properties of reconstructions restored using sinogram restoration with a Huber penalty outperformed those of reconstructions with no restoration. However, the use of a quadratic sinogram restoration penalty did not lead to an improvement over performing no restoration at the outer regions of the phantom. Application of the Huber penalty to neighbors both within a view and across views did not perform as well as only applying the penalty to neighbors within a view. General improvements in resolution-variance properties using sinogram restoration with the Huber penalty were not dependent on the reconstruction method used or the magnitude of the helical pitch. Conclusion: Sinogram restoration for noise and degradation effects for helical cone-beam CT is feasible and should be able to be applied to clinical data. When applied with the edge-preserving Huber penalty

  8. Phantom dosimetry and image quality of i-CAT FLX cone-beam computed tomography

    PubMed Central

    Ludlow, John B.; Walker, Cameron

    2013-01-01

    Introduction Increasing use of cone-beam computed tomography in orthodontics has been coupled with heightened concern with the long-term risks of x-ray exposure in orthodontic populations. An industry response to this has been to offer low-exposure alternative scanning options in newer cone-beam computed tomography models. Methods Effective doses resulting from various combinations of field size, and field location comparing child and adult anthropomorphic phantoms using the recently introduced i-CAT FLX cone-beam computed tomography unit were measured with Optical Stimulated Dosimetry using previously validated protocols. Scan protocols included High Resolution (360° rotation, 600 image frames, 120 kVp, 5 mA, 7.4 sec), Standard (360°, 300 frames, 120 kVp, 5 mA, 3.7 sec), QuickScan (180°, 160 frames, 120 kVp, 5 mA, 2 sec) and QuickScan+ (180°, 160 frames, 90 kVp, 3 mA, 2 sec). Contrast-to-noise ratio (CNR) was calculated as a quantitative measure of image quality for the various exposure options using the QUART DVT phantom. Results Child phantom doses were on average 36% greater than Adult phantom doses. QuickScan+ protocols resulted in significantly lower doses than Standard protocols for child (p=0.0167) and adult (p=0.0055) phantoms. 13×16 cm cephalometric fields of view ranged from 11–85 μSv in the adult phantom and 18–120 μSv in the child for QuickScan+ and Standard protocols respectively. CNR was reduced by approximately 2/3rds comparing QuickScan+ to Standard exposure parameters. Conclusions QuickScan+ effective doses are comparable to conventional panoramic examinations. Significant dose reductions are accompanied by significant reductions in image quality. However, this trade-off may be acceptable for certain diagnostic tasks such as interim assessment of treatment results. PMID:24286904

  9. GPU-accelerated regularized iterative reconstruction for few-view cone beam CT

    SciTech Connect

    Matenine, Dmitri; Goussard, Yves

    2015-04-15

    Purpose: The present work proposes an iterative reconstruction technique designed for x-ray transmission computed tomography (CT). The main objective is to provide a model-based solution to the cone-beam CT reconstruction problem, yielding accurate low-dose images via few-views acquisitions in clinically acceptable time frames. Methods: The proposed technique combines a modified ordered subsets convex (OSC) algorithm and the total variation minimization (TV) regularization technique and is called OSC-TV. The number of subsets of each OSC iteration follows a reduction pattern in order to ensure the best performance of the regularization method. Considering the high computational cost of the algorithm, it is implemented on a graphics processing unit, using parallelization to accelerate computations. Results: The reconstructions were performed on computer-simulated as well as human pelvic cone-beam CT projection data and image quality was assessed. In terms of convergence and image quality, OSC-TV performs well in reconstruction of low-dose cone-beam CT data obtained via a few-view acquisition protocol. It compares favorably to the few-view TV-regularized projections onto convex sets (POCS-TV) algorithm. It also appears to be a viable alternative to full-dataset filtered backprojection. Execution times are of 1–2 min and are compatible with the typical clinical workflow for nonreal-time applications. Conclusions: Considering the image quality and execution times, this method may be useful for reconstruction of low-dose clinical acquisitions. It may be of particular benefit to patients who undergo multiple acquisitions by reducing the overall imaging radiation dose and associated risks.

  10. Karyotype, Pedigree and cone-beam computerized tomography analysis of a case of nonsyndromic pandental anomalies

    PubMed Central

    Dharmani, Umesh; Jadhav, Ganesh Ranganath; Kaur Dharmani, Charan Kamal; Rajput, Akhil; Mittal, Priya; Abraham, Sathish; Soni, Vinay

    2015-01-01

    This case report presented a karyotype and pedigree analysis of a case with unusual combination of dental anomalies: Generalized short roots, talon cusps, dens invagination, low alveolar bone heights, very prominent cusp of carabelli and protostylid on first permanent molars, taurodontism of second permanent molars, rotated, missing and impacted teeth. None of the anomalies alone are rare. However, until date, nonsyndromic pandental anomalies that are affecting entire dentition with detailed karyotype, pedigree and cone-beam computerized tomography analysis have not been reported. The occurrence of these anomalies is probably incidental as the conditions are etiologically unrelated. PMID:26283856

  11. Cone-beam reconstruction for the two-circles-plus-one-line trajectory

    NASA Astrophysics Data System (ADS)

    Lu, Yanbin; Yang, Jiansheng; Emerson, John W.; Mao, Heng; Zhou, Tie; Si, Yuanzheng; Jiang, Ming

    2012-05-01

    The Kodak Image Station In-Vivo FX has an x-ray module with cone-beam configuration for radiographic imaging but lacks the functionality of tomography. To introduce x-ray tomography into the system, we choose the two-circles-plus-one-line trajectory by mounting one translation motor and one rotation motor. We establish a reconstruction algorithm by applying the M-line reconstruction method. Numerical studies and preliminary physical phantom experiment demonstrate the feasibility of the proposed design and reconstruction algorithm.

  12. What is cone-beam CT and how does it work?

    PubMed

    Scarfe, William C; Farman, Allan G

    2008-10-01

    This article on x-ray cone-beam CT (CBCT) acquisition provides an overview of the fundamental principles of operation of this technology and the influence of geometric and software parameters on image quality and patient radiation dose. Advantages of the CBCT system and a summary of the uses and limitations of the images produced are discussed. All current generations of CBCT systems provide useful diagnostic images. Future enhancements most likely will be directed toward reducing scan time; providing multimodal imaging; improving image fidelity, including soft tissue contrast; and incorporating task-specific protocols to minimize patient dose. PMID:18805225

  13. Cone Beam Computed Tomography Image Guidance System for a Dedicated Intracranial Radiosurgery Treatment Unit

    SciTech Connect

    Ruschin, Mark; Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario ; Komljenovic, Philip T.; Ansell, Steve; Menard, Cynthia; Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario ; Bootsma, Gregory; Cho, Young-Bin; Chung, Caroline; Jaffray, David; Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario

    2013-01-01

    Purpose: Image guidance has improved the precision of fractionated radiation treatment delivery on linear accelerators. Precise radiation delivery is particularly critical when high doses are delivered to complex shapes with steep dose gradients near critical structures, as is the case for intracranial radiosurgery. To reduce potential geometric uncertainties, a cone beam computed tomography (CT) image guidance system was developed in-house to generate high-resolution images of the head at the time of treatment, using a dedicated radiosurgery unit. The performance and initial clinical use of this imaging system are described. Methods and Materials: A kilovoltage cone beam CT system was integrated with a Leksell Gamma Knife Perfexion radiosurgery unit. The X-ray tube and flat-panel detector are mounted on a translational arm, which is parked above the treatment unit when not in use. Upon descent, a rotational axis provides 210 Degree-Sign of rotation for cone beam CT scans. Mechanical integrity of the system was evaluated over a 6-month period. Subsequent clinical commissioning included end-to-end testing of targeting performance and subjective image quality performance in phantoms. The system has been used to image 2 patients, 1 of whom received single-fraction radiosurgery and 1 who received 3 fractions, using a relocatable head frame. Results: Images of phantoms demonstrated soft tissue contrast visibility and submillimeter spatial resolution. A contrast difference of 35 HU was easily detected at a calibration dose of 1.2 cGy (center of head phantom). The shape of the mechanical flex vs scan angle was highly reproducible and exhibited <0.2 mm peak-to-peak variation. With a 0.5-mm voxel pitch, the maximum targeting error was 0.4 mm. Images of 2 patients were analyzed offline and submillimeter agreement was confirmed with conventional frame. Conclusions: A cone beam CT image guidance system was successfully adapted to a radiosurgery unit. The system is capable of

  14. Automated volume of interest delineation and rendering of cone beam CT images in interventional cardiology

    NASA Astrophysics Data System (ADS)

    Lorenz, Cristian; Schäfer, Dirk; Eshuis, Peter; Carroll, John; Grass, Michael

    2012-02-01

    Interventional C-arm systems allow the efficient acquisition of 3D cone beam CT images. They can be used for intervention planning, navigation, and outcome assessment. We present a fast and completely automated volume of interest (VOI) delineation for cardiac interventions, covering the whole visceral cavity including mediastinum and lungs but leaving out rib-cage and spine. The problem is addressed in a model based approach. The procedure has been evaluated on 22 patient cases and achieves an average surface error below 2mm. The method is able to cope with varying image intensities, varying truncations due to the limited reconstruction volume, and partially with heavy metal and motion artifacts.

  15. Reproducibilty test of ferrous xylenol orange gel dose response with optical cone beam CT scanning

    NASA Astrophysics Data System (ADS)

    Jordan, K.; Battista, J.

    2004-01-01

    Our previous studies of ferrous xylenol orange gelatin gel have revealed a spatial dependence to the dose response of samples contained in 10 cm diameter cylinders. Dose response is defined as change in optical attenuation coefficient divided by the dose (units cm-1 Gy-1). This set of experiments was conducted to determine the reproducibility of our preparation, irradiation and full 3D optical cone beam CT scanning. The data provided an internal check of a larger storage time-dose response dependence study.

  16. An optimization-based method for geometrical calibration in cone-beam CT without dedicated phantoms

    NASA Astrophysics Data System (ADS)

    Panetta, D.; Belcari, N.; DelGuerra, A.; Moehrs, S.

    2008-07-01

    In this paper we present a new method for the determination of geometrical misalignments in cone-beam CT scanners, from the analysis of the projection data of a generic object. No a priori knowledge of the object shape and positioning is required. We show that a cost function, which depends on the misalignment parameters, can be defined using the projection data and that such a cost function has a local minimum in correspondence to the actual parameters of the system. Hence, the calibration of the scanner can be carried out by minimizing the cost function using standard optimization techniques. The method is developed for a particular class of 3D object functions, for which the redundancy of the fan beam sinogram in the transaxial midplane can be extended to cone-beam projection data, even at wide cone angles. The method has an approximated validity for objects which do not belong to that class; in that case, a suitable subset of the projection data can be selected in order to compute the cost function. We show by numerical simulations that our method is capable to determine with high accuracy the most critical misalignment parameters of the scanner, i.e., the transversal shift and the skew of the detector. Additionally, the detector slant can be determined. Other parameters such as the detector tilt, the longitudinal shift and the error in the source-detector distance cannot be determined with our method, as the proposed cost function has a very weak dependence on them. However, due to the negligible influence of these latter parameters in the reconstructed image quality, they can be kept fixed at estimated values in both calibration and reconstruction processes without compromising the final result. A trade-off between computational cost and calibration accuracy must be considered when choosing the data subset used for the computation of the cost function. Results on real data of a mouse femur as obtained with a small animal micro-CT are shown as well, proving

  17. Use of cone-beam computed tomography in early detection of implant failure.

    PubMed

    Yepes, Juan F; Al-Sabbagh, Mohanad

    2015-01-01

    Preimplant planning with complex imaging techniques has long been a recommended practice for assessing the quality and quantity of alveolar bone before dental implant placement. When maxillofacial imaging is necessary, static film or digital images lack the depth and dimension offered by computed tomography. Cone-beam computed tomography (CBCT) offers the dentist not only a radiographic volumetric view of alveolar bone but also a 3-dimensional reconstruction. This article reviews the use of CBCT for assessing implant placement and early detection of failure, and compares the performance of CBCT with that of other imaging modalities in the early detection of implant failure. PMID:25434558

  18. Cone-beam computed tomography: Time to move from ALARA to ALADA.

    PubMed

    Jaju, Prashant P; Jaju, Sushma P

    2015-12-01

    Cone-beam computed tomography (CBCT) is routinely recommended for dental diagnosis and treatment planning. CBCT exposes patients to less radiation than does conventional CT. Still, lack of proper education among dentists and specialists is resulting in improper referral for CBCT. In addition, aiming to generate high-quality images, operators may increase the radiation dose, which can expose the patient to unnecessary risk. This letter advocates appropriate radiation dosing during CBCT to the benefit of both patients and dentists, and supports moving from the concept of "as low as reasonably achievable" (ALARA) to "as low as diagnostically acceptable" (ALADA). PMID:26730375

  19. Cone beam computed tomography aided diagnosis and treatment of endodontic cases: Critical analysis.

    PubMed

    Yılmaz, Funda; Kamburoglu, Kıvanç; Yeta, Naz Yakar; Öztan, Meltem Dartar

    2016-07-28

    Although intraoral radiographs still remain the imaging method of choice for the evaluation of endodontic patients, in recent years, the utilization of cone beam computed tomography (CBCT) in endodontics showed a significant jump. This case series presentation shows the importance of CBCT aided diagnosis and treatment of complex endodontic cases such as; root resorption, missed extra canal, fusion, oblique root fracture, non-diagnosed periapical pathology and horizontal root fracture. CBCT may be a useful diagnostic method in several endodontic cases where intraoral radiography and clinical examination alone are unable to provide sufficient information. PMID:27551342

  20. A multiscale filter for noise reduction of low-dose cone beam projections.

    PubMed

    Yao, Weiguang; Farr, Jonathan B

    2015-08-21

    The Poisson or compound Poisson process governs the randomness of photon fluence in cone beam computed tomography (CBCT) imaging systems. The probability density function depends on the mean (noiseless) of the fluence at a certain detector. This dependence indicates the natural requirement of multiscale filters to smooth noise while preserving structures of the imaged object on the low-dose cone beam projection. In this work, we used a Gaussian filter, exp(-x2/2σ(2)(f)) as the multiscale filter to de-noise the low-dose cone beam projections. We analytically obtained the expression of σ(f), which represents the scale of the filter, by minimizing local noise-to-signal ratio. We analytically derived the variance of residual noise from the Poisson or compound Poisson processes after Gaussian filtering. From the derived analytical form of the variance of residual noise, optimal σ(2)(f)) is proved to be proportional to the noiseless fluence and modulated by local structure strength expressed as the linear fitting error of the structure. A strategy was used to obtain the reliable linear fitting error: smoothing the projection along the longitudinal direction to calculate the linear fitting error along the lateral direction and vice versa. The performance of our multiscale filter was examined on low-dose cone beam projections of a Catphan phantom and a head-and-neck patient. After performing the filter on the Catphan phantom projections scanned with pulse time 4 ms, the number of visible line pairs was similar to that scanned with 16 ms, and the contrast-to-noise ratio of the inserts was higher than that scanned with 16 ms about 64% in average. For the simulated head-and-neck patient projections with pulse time 4 ms, the visibility of soft tissue structures in the patient was comparable to that scanned with 20 ms. The image processing took less than 0.5 s per projection with 1024   ×   768 pixels. PMID:26247344

  1. Florid cemento-osseous dysplasia: A rare case report evaluated with cone-beam computed tomography.

    PubMed

    Yildirim, Eren; Bağlar, Serdar; Ciftci, Mehmet Ertugrul; Ozcan, Erdal

    2016-01-01

    A 29-year-old systemically healthy female patient presented to our department. Cone-beam computed tomographic images showed multiple well-defined sclerotic masses with radiolucent border in both right and left molar regions of the mandible. These sclerotic masses were surrounded by a thin radiolucent border. We diagnosed the present pathology as florid cemento-osseous dysplasia and decided to follow the patient without taking biopsy. For the patient, who did not have any clinical complaints, radiographic followupis recommended twice a year. The responsibility of the dentist is to ensure the follow-up of the diagnosed patients and take necessary measures for preventing the infections. PMID:27601835

  2. Florid cemento-osseous dysplasia: A rare case report evaluated with cone-beam computed tomography

    PubMed Central

    Yildirim, Eren; Bağlar, Serdar; Ciftci, Mehmet Ertugrul; Ozcan, Erdal

    2016-01-01

    A 29-year-old systemically healthy female patient presented to our department. Cone-beam computed tomographic images showed multiple well-defined sclerotic masses with radiolucent border in both right and left molar regions of the mandible. These sclerotic masses were surrounded by a thin radiolucent border. We diagnosed the present pathology as florid cemento-osseous dysplasia and decided to follow the patient without taking biopsy. For the patient, who did not have any clinical complaints, radiographic followupis recommended twice a year. The responsibility of the dentist is to ensure the follow-up of the diagnosed patients and take necessary measures for preventing the infections. PMID:27601835

  3. Cone beam computed tomography aided diagnosis and treatment of endodontic cases: Critical analysis

    PubMed Central

    Yılmaz, Funda; Kamburoglu, Kıvanç; Yeta, Naz Yakar; Öztan, Meltem Dartar

    2016-01-01

    Although intraoral radiographs still remain the imaging method of choice for the evaluation of endodontic patients, in recent years, the utilization of cone beam computed tomography (CBCT) in endodontics showed a significant jump. This case series presentation shows the importance of CBCT aided diagnosis and treatment of complex endodontic cases such as; root resorption, missed extra canal, fusion, oblique root fracture, non-diagnosed periapical pathology and horizontal root fracture. CBCT may be a useful diagnostic method in several endodontic cases where intraoral radiography and clinical examination alone are unable to provide sufficient information. PMID:27551342

  4. Cone-beam computed tomography: Time to move from ALARA to ALADA

    PubMed Central

    Jaju, Sushma P.

    2015-01-01

    Cone-beam computed tomography (CBCT) is routinely recommended for dental diagnosis and treatment planning. CBCT exposes patients to less radiation than does conventional CT. Still, lack of proper education among dentists and specialists is resulting in improper referral for CBCT. In addition, aiming to generate high-quality images, operators may increase the radiation dose, which can expose the patient to unnecessary risk. This letter advocates appropriate radiation dosing during CBCT to the benefit of both patients and dentists, and supports moving from the concept of "as low as reasonably achievable" (ALARA) to "as low as diagnostically acceptable" (ALADA). PMID:26730375

  5. Contrast-to-noise ratio improvement in volume-of-interest cone beam breast CT

    NASA Astrophysics Data System (ADS)

    Shen, Youtao; Liu, Xinming; Lai, Chao-Jen; Zhong, Yuncheng; Yi, Ying; You, Zhicheng; Wang, Tianpeng; Shaw, Chris C.

    2012-03-01

    In this study, we demonstrated the contrast-to-noise ratio (CNR) improvement in breast cone beam CT (CBCT) using the volume-of-interest (VOI) scanning technique. In VOI breast CBCT, the breast is first scanned at a low exposure level. A pre-selected VOI is then scanned at a higher exposure level with collimated x-rays. The two image sets are combined together to reconstruct high quality 3-D images of the VOI. A flat panel detector based system was built to demonstrate and investigate the CNR improvement in VOI breast CBCT. The CNRs of the 8 plastic cones (Teflon, Delrin, polycarbonate, Lucite, solid water, high density polystyrene, nylon and polystyrene) in a breast phantom were measured in images obtained with the VOI CBCT technique and compared to those measured in standard full field CBCT images. CNRs in VOI CBCT images were found to be higher than those in regular CBCT images in all plastic cones. The mean glandular doses (MGDs) from the combination of a high exposure VOI scan and a low exposure full-field scan was estimated to be similar to that from regular full-field scan at standard exposure level. The VOI CBCT technique allows a VOI to be imaged with enhanced image quality with an MGD similar to that from regular CBCT technique.

  6. Iterative reconstruction optimisations for high angle cone-beam micro-CT

    NASA Astrophysics Data System (ADS)

    Recur, B.; Fauconneau, M.; Kingston, A.; Myers, G.; Sheppard, A.

    2014-09-01

    We address several acquisition questions that have arisen for the high cone-angle helical-scanning micro-CT facility developed at the Australian National University. These challenges are generally known in medical and industrial cone-beam scanners but can be neglected in these systems. For our large datasets, with more than 20483 voxels, minimising the number of operations (or iterations) is crucial. Large cone-angles enable high signal-to-noise ratio imaging and a large helical pitch to be used. This introduces two challenges: (i) non-uniform resolution throughout the reconstruction, (ii) over-scan beyond the region-of-interest significantly increases re- quired reconstructed volume size. Challenge (i) can be addressed by using a double-helix or lower pitch helix but both solutions slow down iterations. Challenge (ii) can also be improved by using a lower pitch helix but results in more projections slowing down iterations. This may be overcome using less projections per revolution but leads to more iterations required. Here we assume a given total time for acquisition and a given reconstruction technique (SART) and seek to identify the optimal trajectory and number of projections per revolution in order to produce the best tomogram, minimise reconstruction time required, and minimise memory requirements.

  7. Brain SPECT with short focal-length cone-beam collimation

    SciTech Connect

    Park, Mi-Ae; Moore, Stephen C.; Kijewski, Marie Foley

    2005-07-15

    Single-photon emission-computed tomography (SPECT) imaging of deep brain structures is compromised by loss of photons due to attenuation. We have previously shown that a centrally peaked collimator sensitivity function can compensate for this phenomenon, increasing sensitivity over most of the brain. For dual-head instruments, parallel-hole collimators cannot provide variable sensitivity without simultaneously degrading spatial resolution near the center of the brain; this suggests the use of converging collimators. We have designed collimator pairs for dual-head SPECT systems to increase sensitivity, particularly in the center of the brain, and compared the new collimation approach to existing approaches on the basis of performance in estimating activity concentration of small structures at various locations in the brain. The collimator pairs we evaluated included a cone-beam collimator, for increased sensitivity, and a fan-beam collimator, for data sufficiency. We calculated projections of an ellipsoidal uniform background, with 0.9-cm-radius spherical lesions at several locations in the background. From these, we determined ideal signal-to-noise ratios (SNR{sub CRB}) for estimation of activity concentration within the spheres, based on the Cramer-Rao lower bound on variance. We also reconstructed, by an ordered-subset expectation-maximization (OS-EM) procedure, images of this phantom, as well as of the Zubal brain phantom, to allow visual assessment and to ensure that they were free of artifacts. The best of the collimator pairs evaluated comprised a cone-beam collimator with 20 cm focal length, for which the focal point is inside the brain, and a fan-beam collimator with 40 cm focal length. This pair yielded increased SNR{sub CRB}, compared to the parallel-parallel pair, throughout the imaging volume. The factor by which SNR{sub CRB} increased ranged from 1.1 at the most axially extreme location to 3.5 at the center. The gains in SNR{sub CRB} were relatively

  8. Enhancement of breast calcification visualization and detection using a modified PG method in Cone Beam Breast CT.

    PubMed

    Liu, Jiangkun; Ning, Ruola; Cai, Weixing; Benitez, Ricardo Betancourt

    2012-01-01

    Cone Beam Breast CT is a promising diagnostic modality in breast imaging. Its isotropic 3D spatial resolution enhances the characterization of micro-calcifications in breasts that might not be easily distinguishable in mammography. However, due to dose level considerations, it is beneficial to further enhance the visualization of calcifications in Cone Beam Breast CT images that might be masked by noise. In this work, the Papoulis-Gerchberg method was modified and implemented in Cone Beam Breast CT images to improve the visualization and detectability of calcifications. First, the PG method was modified and applied to the projections acquired during the scanning process; its effects on the reconstructed images were analyzed by measuring the Modulation Transfer Function and the Noise Power Spectrum. Second, Cone Beam Breast CT images acquired at different dose levels were pre-processed using this technique to enhance the visualization of calcification. Finally, a computer-aided diagnostic algorithm was utilized to evaluate the efficacy of this method to improve calcification detectability. The results demonstrated that this technique can effectively improve image quality by improving the Modulation Transfer Function with a minor increase in noise level. Consequently, the visualization and detectability of calcifications were improved in Cone Beam Breast CT images. This technique was also proved to be useful in reducing the x-ray dose without degrading visualization and detectability of calcifications. PMID:22398591

  9. Reconstruction-plane-dependent weighted FDK algorithm for cone beam volumetric CT

    NASA Astrophysics Data System (ADS)

    Tang, Xiangyang; Hsieh, Jiang

    2005-04-01

    The original FDK algorithm has been extensively employed in medical and industrial imaging applications. With an increased cone angle, cone beam (CB) artifacts in images reconstructed by the original FDK algorithm deteriorate, since the circular trajectory does not satisfy the so-called data sufficiency condition (DSC). A few "circular plus" trajectories have been proposed in the past to reduce CB artifacts by meeting the DSC. However, the circular trajectory has distinct advantages over other scanning trajectories in practical CT imaging, such as cardiac, vascular and perfusion applications. In addition to looking into the DSC, another insight into the CB artifacts of the original FDK algorithm is the inconsistency between conjugate rays that are 180° apart in view angle. The inconsistence between conjugate rays is pixel dependent, i.e., it varies dramatically over pixels within the image plane to be reconstructed. However, the original FDK algorithm treats all conjugate rays equally, resulting in CB artifacts that can be avoided if appropriate view weighting strategy is exercised. In this paper, a modified FDK algorithm is proposed, along with an experimental evaluation and verification, in which the helical body phantom and a humanoid head phantom scanned by a volumetric CT (64 x 0.625 mm) are utilized. Without extra trajectories supplemental to the circular trajectory, the modified FDK algorithm applies reconstruction-plane-dependent view weighting on projection data before 3D backprojection, which reduces the inconsistency between conjugate rays by suppressing the contribution of one of the conjugate rays with a larger cone angle. Both computer-simulated and real phantom studies show that, up to a moderate cone angle, the CB artifacts can be substantially suppressed by the modified FDK algorithm, while advantages of the original FDK algorithm, such as the filtered backprojection algorithm structure, 1D ramp filtering, and data manipulation efficiency, can be

  10. Radiobiologically optimized couch shift: A new localization paradigm using cone-beam CT for prostate radiotherapy

    SciTech Connect

    Huang, Yimei Gardner, Stephen J.; Wen, Ning; Zhao, Bo; Gordon, James; Brown, Stephen; Chetty, Indrin J.

    2015-10-15

    Purpose: To present a novel positioning strategy which optimizes radiation delivery by utilizing radiobiological response knowledge and evaluate its use during prostate external beam radiotherapy. Methods: Five patients with low or intermediate risk prostate cancer were evaluated retrospectively in this IRB-approved study. For each patient, a VMAT plan with one 358° arc was generated on the planning CT (PCT) to deliver 78 Gy in 39 fractions. Five representative pretreatment cone beam CTs (CBCT) were selected for each patient. The CBCT images were registered to PCT by a human observer, which consisted of an initial automated registration with three degrees-of-freedom, followed by manual adjustment for agreement at the prostate/rectal wall interface. To determine the optimal treatment position for each CBCT, a search was performed centering on the observer-matched position (OM-position) utilizing a score function based on radiobiological and dosimetric indices (EUD{sub prostate}, D99{sub prostate}, NTCP{sub rectum}, and NTCP{sub bladder}) for the prostate, rectum, and bladder. We termed the optimal treatment position the radiobiologically optimized couch shift position (ROCS-position). Results: The dosimetric indices, averaged over the five patients’ treatment plans, were (mean ± SD) 79.5 ± 0.3 Gy (EUD{sub prostate}), 78.2 ± 0.4 Gy (D99{sub prostate}), 11.1% ± 2.7% (NTCP{sub rectum}), and 46.9% ± 7.6% (NTCP{sub bladder}). The corresponding values from CBCT at the OM-positions were 79.5 ± 0.6 Gy (EUD{sub prostate}), 77.8 ± 0.7 Gy (D99{sub prostate}), 12.1% ± 5.6% (NTCP{sub rectum}), and 51.6% ± 15.2% (NTCP{sub bladder}), respectively. In comparison, from CBCT at the ROCS-positions, the dosimetric indices were 79.5 ± 0.6 Gy (EUD{sub prostate}), 77.3 ± 0.6 Gy (D99{sub prostate}), 8.0% ± 3.3% (NTCP{sub rectum}), and 46.9% ± 15.7% (NTCP{sub bladder}). Excessive NTCP{sub rectum} was observed on Patient 5 (19.5% ± 6.6%) corresponding to localization at OM

  11. A novel extension of the parallel-beam projection-slice theorem to divergent fan-beam and cone-beam projections.

    PubMed

    Chen, Guang-Hong; Leng, Shuai; Mistretta, Charles A

    2005-03-01

    The general goal of this paper is to extend the parallel-beam projection-slice theorem to divergent fan-beam and cone-beam projections without rebinning the divergent fan-beam and cone-beam projections into parallel-beam projections directly. The basic idea is to establish a novel link between the local Fourier transform of the projection data and the Fourier transform of the image object. Analogous to the two- and three-dimensional parallel-beam cases, the measured projection data are backprojected along the projection direction and then a local Fourier transform is taken for the backprojected data array. However, due to the loss of the shift invariance of the image object in a single view of the divergent-beam projections, the measured projection data is weighted by a distance dependent weight w(r) before the local Fourier transform is performed. The variable r in the weighting function w(r) is the distance from the backprojected point to the x-ray source position. It is shown that a special choice of the weighting function, w(r)=1/r, will facilitate the calculations and a simple relation can be established between the Fourier transform of the image function and the local Fourier transform of the 1/r-weighted backprojection data array. Unlike the parallel-beam cases, a one-to-one correspondence does not exist for a local Fourier transform of the backprojected data array and a single line in the two-dimensional (2D) case or a single slice in the 3D case of the Fourier transform of the image function. However, the Fourier space of the image object can be built up after the local Fourier transforms of the 1/r-weighted backprojection data arrays are shifted and then summed in a laboratory frame. Thus the established relations Eq. (27) and Eq. (29) between the Fourier space of the image object and the Fourier transforms of the backprojected data arrays can be viewed as a generalized projection-slice theorem for divergent fan-beam and cone-beam projections. Once the

  12. CCD detectors for fast neutron radiography and tomography with a cone beam

    NASA Astrophysics Data System (ADS)

    Bogolubov, E.; Bugaenko, O.; Kuzin, S.; Mikerov, V.; Monitch, E.; Monitch, A.; Pertsov, A.

    2005-04-01

    Two new types of luminescent CCD-detectors intended for fast neutron radiography and tomography with a cone neutron beam are described in the paper. A 6 cm thick luminescent screen made of polystyrene is used in the first one to convert fast neutrons. A special optics has been developed to transfer the optical image from the screen to the CCD-matrix. The optics design helps not to loose spatial resolution due to the beam divergence and screen thickness. The second detector is based on the use of a fiber optical screen made of luminescent fibers in the form of a rectangular truncated pyramid. Principles of the detectors operation have been experimentally proved. The obtained results show that the detectors provide a spatial resolution of about 2 mm.

  13. Variation of patient imaging doses with scanning parameters for linac-integrated kilovoltage cone beam CT.

    PubMed

    Liao, Xiongfei; Wang, Yunlai; Lang, Jinyi; Wang, Pei; Li, Jie; Ge, Ruigang; Yang, Jack

    2015-01-01

    To evaluate the Elekta kilovoltage CBCT doses and the associated technical protocols with patient dosimetry estimation. Image guidance technique with cone-beam CT (CBCT) in radiation oncology on a daily basis can deliver a significant dose to the patient. To evaluate the patient dose from LINAC-integrated kV cone beam CT imaging in image-guided radiotherapy. CT dose index (CTDI) were measured with PTW TM30009 CT ion chamber in air, in head phantom and body phantom, respectively; with different combinations of tube voltage, current, exposure time per frame, collimator and gantry rotation range. Dose length products (DLP) were subsequently calculated to account for volume integration effects. The CTDI and DLP were also compared to AcQSim™ simulator CT for routine clinical protocols. Both CTDIair and CTDIw depended quadratically on the voltage, while linearly on milliampere x seconds (mAs) settings. It was shown that CTDIw and DLP had very close relationship with the collimator settings and the gantry rotation ranges. Normalized CTDIw for Elekta XVI™ CBCT was lower than that of ACQSim simulator CT owing to its pulsed radiation output characteristics. CTDIw can be used to assess the patient dose in CBCT due to its simplicity for measurement and reproducibility. Regular measurement should be performed in QA & QC program. Optimal image parameters should be chosen to reduce patient dose during CBCT. PMID:26405932

  14. Augmented reality and cone beam CT guidance for transoral robotic surgery.

    PubMed

    Liu, Wen P; Richmon, Jeremy D; Sorger, Jonathan M; Azizian, Mahdi; Taylor, Russell H

    2015-09-01

    In transoral robotic surgery preoperative image data do not reflect large deformations of the operative workspace from perioperative setup. To address this challenge, in this study we explore image guidance with cone beam computed tomographic angiography to guide the dissection of critical vascular landmarks and resection of base-of-tongue neoplasms with adequate margins for transoral robotic surgery. We identify critical vascular landmarks from perioperative c-arm imaging to augment the stereoscopic view of a da Vinci si robot in addition to incorporating visual feedback from relative tool positions. Experiments resecting base-of-tongue mock tumors were conducted on a series of ex vivo and in vivo animal models comparing the proposed workflow for video augmentation to standard non-augmented practice and alternative, fluoroscopy-based image guidance. Accurate identification of registered augmented critical anatomy during controlled arterial dissection and en bloc mock tumor resection was possible with the augmented reality system. The proposed image-guided robotic system also achieved improved resection ratios of mock tumor margins (1.00) when compared to control scenarios (0.0) and alternative methods of image guidance (0.58). The experimental results show the feasibility of the proposed workflow and advantages of cone beam computed tomography image guidance through video augmentation of the primary stereo endoscopy as compared to control and alternative navigation methods. PMID:26531203

  15. Cone beam CT evaluation of the presence of anatomic accessory canals in the jaws

    PubMed Central

    Eshak, M; Brooks, S; Abdel-Wahed, N

    2014-01-01

    Objectives: To assess the prevalence, location and anatomical course of accessory canals of the jaws using cone beam CT. Methods: A retrospective analysis of 4200 successive cone beam CT scans, for patients of both genders and ages ranging from 7 to 88 years, was performed. They were exposed at the School of Dentistry, University of Michigan, Ann Arbor, MI. After applying the exclusion criteria (the presence of severe ridge resorption, pre-existing implants, a previously reported history of craniofacial malformations or syndromes, a previous history of trauma or surgery, inadequate image quality and subsequent scans from the same individuals), 4051 scans were ultimately included in this study. Results: Of the 4051 scans (2306 females and 1745 males) that qualified for inclusion in this study, accessory canals were identified in 1737 cases (42.9%; 1004 females and 733 males). 532 scans were in the maxilla (13.1%; 296 females and 236 males) and 1205 in the mandible (29.8%; 708 females and 497 males). Conclusions: A network of accessory canals bringing into communication the inner and outer cortical plates of the jaws was identified. In light of these findings, clinicians should carefully assess for the presence of accessory canals prior to any surgical intervention to decrease the risk for complications. PMID:24670010

  16. Does cone beam CT actually ameliorate stab wound analysis in bone?

    PubMed

    Gaudio, D; Di Giancamillo, M; Gibelli, D; Galassi, A; Cerutti, E; Cattaneo, C

    2014-01-01

    This study aims at verifying the potential of a recent radiological technology, cone beam CT (CBCT), for the reproduction of digital 3D models which may allow the user to verify the inner morphology of sharp force wounds within the bone tissue. Several sharp force wounds were produced by both single and double cutting edge weapons on cancellous and cortical bone, and then acquired by cone beam CT scan. The lesions were analysed by different software (a DICOM file viewer and reverse engineering software). Results verified the limited performances of such technology for lesions made on cortical bone, whereas on cancellous bone reliable models were obtained, and the precise morphology within the bone tissues was visible. On the basis of such results, a method for differential diagnosis between cutmarks by sharp tools with a single and two cutting edges can be proposed. On the other hand, the metrical computerised analysis of lesions highlights a clear increase of error range for measurements under 3 mm. Metric data taken by different operators shows a strong dispersion (% relative standard deviation). This pilot study shows that the use of CBCT technology can improve the investigation of morphological stab wounds on cancellous bone. Conversely metric analysis of the lesions as well as morphological analysis of wound dimension under 3 mm do not seem to be reliable. PMID:23392761

  17. Accuracy of cone-beam computerized tomography in determining the thickness of palatal masticatory mucosa

    PubMed Central

    Gupta, Prabhati; Jan, Suhail Majid; Behal, Roobal; Mir, Reyaz Ahmad; Shafi, Munaza

    2015-01-01

    Background: The palatal masticatory mucosa is the main donor area of soft tissue and connective tissue grafts used for increasing the keratinized mucosa around teeth and implants, covering exposed roots and increasing localized alveolar ridge thickness. The aim of this study was to compare the thickness of the palatal masticatory mucosa as determined on a cone-beam computerized tomography scan versus thickness determined via bone-sounding. Materials and Methods: A total of 20 patients requiring palatal surgery participated. Thickness of the palatal tissue was measured at various points radiographically and clinically. The two techniques were compared to determine the agreement of the two measurement modalities. Results: Statistical analysis determined that there was no significant difference between the two methods. Moreover, the tissue thickness was shown to increase as the distance from the gingival margin increased, and the tissue over the premolars was thicker than the other teeth. Conclusion: Cone-beam computerized tomography can be used as a noninvasive method to accurately and consistently determine the soft tissue thickness of the palatal masticatory mucosa with minimal bias at different locations on the palate. PMID:26392687

  18. The sensitivity and accuracy of a cone beam CT in detecting the chorda tympani.

    PubMed

    Hiraumi, Harukazu; Suzuki, Ryo; Yamamoto, Norio; Sakamoto, Tatsunori; Ito, Juichi

    2016-04-01

    The facial recess approach through posterior tympanotomy is the standard approach in cochlear implantation surgery. The size of the facial recess is highly variable, depending on the course of the chorda tympani. Despite their clinical importance, little is known about the sensitivity and accuracy of imaging studies in the detection of the chorda tympani. A total of 13 human temporal bones were included in this study. All of the temporal bones were submitted to a cone beam CT (Accuitomo, Morita, Japan). The multi-planar reconstruction images were rotated around the mastoid portion of the facial nerve to locate the branches of the facial nerve. A branch was diagnosed as the chorda tympani when it entered the tympanic cavity near the notch of Rivinus. The distance between the bifurcation and the tip of the short crus of the incus was measured. In all temporal bones, the canal of the chorda tympani or the posterior canaliculus was detected. In the CT-based evaluation, the average distance from the bifurcation to the incus short crus was 12.6 mm (8.3-15.8 mm). The actual distance after dissection was 12.4 mm (8.2-16.4 mm). The largest difference between the distances evaluated with the two procedures was 1.1 mm. Cone beam CT is very useful in detecting the course of the chorda tympani within the temporal bone. The measured distance is accurate. PMID:25956616

  19. Planar cone-beam computed tomography with a flat-panel detector

    NASA Astrophysics Data System (ADS)

    Kim, S. H.; Kim, D. W.; Youn, H.; Kim, D.; Kam, S.; Jeon, H.; Kim, H. K.

    2015-12-01

    For a dedicated x-ray inspection of printed-circuit boards (PCBs), a bench-top planar cone-beam computed tomography (pCT) system with a flat-panel detector has been built in the laboratory. The system adopts the tomosynthesis technique that can produce cross-sectional images parallel to the axis of rotation for a limited angular range. For the optimal operation of the system and further improvement in the next design, we have evaluated imaging performances, such as modulation-transfer function, noise-power spectrum, and noise-equivalent number of quanta. The performances are comparatively evaluated with the coventional cone-beam CT (CBCT) acquisition for various scanning angular ranges, applied tube voltages, and geometrical magnification factors. The pCT scan shows a poorer noise performance than the conventional CBCT scan because of less number of projection views used for reconstruction. However, the pCT shows a better spatial-resolution performance than the CBCT. Because the image noise can be compensated by an elevated exposure level during scanning, the pCT can be a useful modality for the PCB inspection that requires higher spatial-resolution performance.

  20. In Vitro Detection of Dental Root Fractures with Cone Beam Computed Tomography (CBCT)

    PubMed Central

    Fisekcioglu, Erdogan; Dolekoglu, Semanur; Ilguy, Mehmet; Ersan, Nilufer; Ilguy, Dilhan

    2014-01-01

    Background: Since the diagnosis of non-displaced longitudinal fractures present difficulties for the dentist, three-dimensional evaluation is necessary. Objectives: The aim of this study is to demonstrate the accuracy of cone beam computed tomography (CBCT) in detecting dental root fractures in vitro. Materials and Methods: An in vitro model consisting of 210 recently extracted human mandibular teeth was used. Root fractures were created by mechanical force. The teeth were placed randomly in the empty dental alveoli of a dry human mandible and 15 different dental arcs were created. Images were taken with a unit Iluma ultra cone-beam CT scanner (Imtec Corporation, Germany). Three dental radiologists separately evaluated the images. Results: According to the fracture types and fracture presence, there was an overall statistically significant agreement between the key and readings. Kappa values for intra observer agreement ranged between 0.705 and 0.804 indicating that each observer gave acceptable ratings for the type and presence of fractures. Conclusions: Detailed information about root fractures may be obtained using CBCT. PMID:24693295

  1. Three-dimensional C-arm cone-beam CT: applications in the interventional suite.

    PubMed

    Wallace, Michael J; Kuo, Michael D; Glaiberman, Craig; Binkert, Christoph A; Orth, Robert C; Soulez, Gilles

    2008-06-01

    C-arm cone-beam computed tomography (CT) with a flat-panel detector represents the next generation of imaging technology available in the interventional radiology suite and is predicted to be the platform for many of the three-dimensional (3D) roadmapping and navigational tools that will emerge in parallel with its integration. The combination of current and unappreciated capabilities may be the foundation on which improvements in both safety and effectiveness of complex vascular and nonvascular interventional procedures become possible. These improvements include multiplanar soft tissue imaging, enhanced pretreatment target lesion roadmapping and guidance, and the ability for immediate multiplanar posttreatment assessment. These key features alone may translate to a reduction in the use of iodinated contrast media, a decrease in the radiation dose to the patient and operator, and an increase in the therapeutic index (increase in the safety-vs-benefit ratio). In routine practice, imaging information obtained with C-arm cone-beam CT provides a subjective level of confidence factor to the operator that has not yet been thoroughly quantified. PMID:18503893

  2. Three-dimensional C-arm cone-beam CT: applications in the interventional suite.

    PubMed

    Wallace, Michael J; Kuo, Michael D; Glaiberman, Craig; Binkert, Christoph A; Orth, Robert C; Soulez, Gilles

    2009-07-01

    C-arm cone-beam computed tomography (CT) with a flat-panel detector represents the next generation of imaging technology available in the interventional radiology suite and is predicted to be the platform for many of the three-dimensional (3D) roadmapping and navigational tools that will emerge in parallel with its integration. The combination of current and unappreciated capabilities may be the foundation on which improvements in both safety and effectiveness of complex vascular and nonvascular interventional procedures become possible. These improvements include multiplanar soft tissue imaging, enhanced pretreatment target lesion roadmapping and guidance, and the ability for immediate multiplanar posttreatment assessment. These key features alone may translate to a reduction in the use of iodinated contrast media, a decrease in the radiation dose to the patient and operator, and an increase in the therapeutic index (increase in safety-vs-benefit ratio). In routine practice, imaging information obtained with C-arm cone-beam CT provides a subjective level of confidence factor to the operator that has not yet been thoroughly quantified. PMID:19560037

  3. Iterative image reconstruction for limited-angle inverse helical cone-beam computed tomography.

    PubMed

    Yu, Wei; Zeng, Li

    2016-01-01

    Helical trajectory satisfying the condition of exact reconstruction, has been widely utilized in the commercial computed tomography (CT). While limited by the scanning environment in some practical applications, the conventional helical cone-beam CT imaging is hard to complete, thus, developing an imaging system suited for long-object may be valuable. Three-dimensional C-arm CT is an innovative imaging technique which has been greatly concerned. Since there is a high degree of freedom of C-arm, more flexible image acquisition trajectories for 3D imaging can be achieved. In this work, a fast iterative reconstruction algorithm based on total variation minimization is developed for a trajectory of limited-angle inverse helical cone-beam CT, which can be applied to detect long-object without slip-ring technology. The experimental results show that the developed algorithm can yield reconstructed images of low noise level and high image quality. SCANNING 38:4-13, 2016. © 2015 Wiley Periodicals, Inc. PMID:26130367

  4. Ring artifacts removal via spatial sparse representation in cone beam CT

    NASA Astrophysics Data System (ADS)

    Li, Zhongyuan; Li, Guang; Sun, Yi; Luo, Shouhua

    2016-03-01

    This paper is about the ring artifacts removal method in cone beam CT. Cone beam CT images often suffer from disturbance of ring artifacts which caused by the non-uniform responses of the elements in detectors. Conventional ring artifacts removal methods focus on the correlation of the elements and the ring artifacts' structural characteristics in either sinogram domain or cross-section image. The challenge in the conventional methods is how to distinguish the artifacts from the intrinsic structures; hence they often give rise to the blurred image results due to over processing. In this paper, we investigate the characteristics of the ring artifacts in spatial space, different from the continuous essence of 3D texture feature of the scanned objects, the ring artifacts are displayed discontinuously in spatial space, specifically along z-axis. Thus we can easily recognize the ring artifacts in spatial space than in cross-section. As a result, we choose dictionary representation for ring artifacts removal due to its high sensitivity to structural information. We verified our theory both in spatial space and coronal-section, the experimental results demonstrate that our methods can remove the artifacts efficiently while maintaining image details.

  5. Patient dose and image quality from mega-voltage cone beam computed tomography imaging

    SciTech Connect

    Gayou, Olivier; Parda, David S.; Johnson, Mark; Miften, Moyed

    2007-02-15

    The evolution of ever more conformal radiation delivery techniques makes the subject of accurate localization of increasing importance in radiotherapy. Several systems can be utilized including kilo-voltage and mega-voltage cone-beam computed tomography (MV-CBCT), CT on rail or helical tomography. One of the attractive aspects of mega-voltage cone-beam CT is that it uses the therapy beam along with an electronic portal imaging device to image the patient prior to the delivery of treatment. However, the use of a photon beam energy in the mega-voltage range for volumetric imaging degrades the image quality and increases the patient radiation dose. To optimize image quality and patient dose in MV-CBCT imaging procedures, a series of dose measurements in cylindrical and anthropomorphic phantoms using an ionization chamber, radiographic films, and thermoluminescent dosimeters was performed. Furthermore, the dependence of the contrast to noise ratio and spatial resolution of the image upon the dose delivered for a 20-cm-diam cylindrical phantom was evaluated. Depending on the anatomical site and patient thickness, we found that the minimum dose deposited in the irradiated volume was 5-9 cGy and the maximum dose was between 9 and 17 cGy for our clinical MV-CBCT imaging protocols. Results also demonstrated that for high contrast areas such as bony anatomy, low doses are sufficient for image registration and visualization of the three-dimensional boundaries between soft tissue and bony structures. However, as the difference in tissue density decreased, the dose required to identify soft tissue boundaries increased. Finally, the dose delivered by MV-CBCT was simulated using a treatment planning system (TPS), thereby allowing the incorporation of MV-CBCT dose in the treatment planning process. The TPS-calculated doses agreed well with measurements for a wide range of imaging protocols.

  6. Guiding and focusing of fast electron beams produced by ultra-intense laser pulse using a double cone funnel target

    NASA Astrophysics Data System (ADS)

    Zhang, Wen-shuai; Cai, Hong-bo; Zhu, Shao-ping

    2015-10-01

    A novel double cone funnel target design aiming at efficiently guiding and focusing fast electron beams produced in high intensity (>1019 W/cm2) laser-solid interactions is investigated via two-dimensional particle-in-cell simulations. The forward-going fast electron beams are shown to be directed and focused to a smaller size in comparison with the incident laser spot size. This plasma funnel attached on the cone target guides and focuses electrons in a manner akin to the control of liquid by a plastic funnel. Such device has the potential to add substantial design flexibility and prevent inefficiencies for important applications such as fast ignition. Two reasons account for the collimation of fast electron beams. First, the sheath electric fields and quasistatic magnetic fields inside the vacuum gap of the double cone provide confinement of the fast electrons in the laser-plasma interaction region. Second, the interface magnetic fields inside the beam collimator further guide and focus the fast electrons during the transport. The application of this technique to cone-guided fast ignition is considered, and it is shown that it can enhance the laser energy deposition in the compressed fuel plasma by a factor of 2 in comparison with the single cone target case.

  7. Guiding and focusing of fast electron beams produced by ultra-intense laser pulse using a double cone funnel target

    SciTech Connect

    Zhang, Wen-shuai; Cai, Hong-bo; Zhu, Shao-ping

    2015-10-15

    A novel double cone funnel target design aiming at efficiently guiding and focusing fast electron beams produced in high intensity (>10{sup 19 }W/cm{sup 2}) laser-solid interactions is investigated via two-dimensional particle-in-cell simulations. The forward-going fast electron beams are shown to be directed and focused to a smaller size in comparison with the incident laser spot size. This plasma funnel attached on the cone target guides and focuses electrons in a manner akin to the control of liquid by a plastic funnel. Such device has the potential to add substantial design flexibility and prevent inefficiencies for important applications such as fast ignition. Two reasons account for the collimation of fast electron beams. First, the sheath electric fields and quasistatic magnetic fields inside the vacuum gap of the double cone provide confinement of the fast electrons in the laser-plasma interaction region. Second, the interface magnetic fields inside the beam collimator further guide and focus the fast electrons during the transport. The application of this technique to cone-guided fast ignition is considered, and it is shown that it can enhance the laser energy deposition in the compressed fuel plasma by a factor of 2 in comparison with the single cone target case.

  8. Analytic image reconstruction from partial data for a single-scan cone-beam CT with scatter correction

    SciTech Connect

    Min, Jonghwan; Pua, Rizza; Cho, Seungryong; Kim, Insoo; Han, Bumsoo

    2015-11-15

    Purpose: A beam-blocker composed of multiple strips is a useful gadget for scatter correction and/or for dose reduction in cone-beam CT (CBCT). However, the use of such a beam-blocker would yield cone-beam data that can be challenging for accurate image reconstruction from a single scan in the filtered-backprojection framework. The focus of the work was to develop an analytic image reconstruction method for CBCT that can be directly applied to partially blocked cone-beam data in conjunction with the scatter correction. Methods: The authors developed a rebinned backprojection-filteration (BPF) algorithm for reconstructing images from the partially blocked cone-beam data in a circular scan. The authors also proposed a beam-blocking geometry considering data redundancy such that an efficient scatter estimate can be acquired and sufficient data for BPF image reconstruction can be secured at the same time from a single scan without using any blocker motion. Additionally, scatter correction method and noise reduction scheme have been developed. The authors have performed both simulation and experimental studies to validate the rebinned BPF algorithm for image reconstruction from partially blocked cone-beam data. Quantitative evaluations of the reconstructed image quality were performed in the experimental studies. Results: The simulation study revealed that the developed reconstruction algorithm successfully reconstructs the images from the partial cone-beam data. In the experimental study, the proposed method effectively corrected for the scatter in each projection and reconstructed scatter-corrected images from a single scan. Reduction of cupping artifacts and an enhancement of the image contrast have been demonstrated. The image contrast has increased by a factor of about 2, and the image accuracy in terms of root-mean-square-error with respect to the fan-beam CT image has increased by more than 30%. Conclusions: The authors have successfully demonstrated that the

  9. Does cone-beam CT alter treatment plans? Comparison of preoperative implant planning using panoramic versus cone-beam CT images

    PubMed Central

    Guerrero, Maria Eugenia; Noriega, Jorge; Castro, Carmen

    2014-01-01

    Purpose The present study was performed to compare the planning of implant placement based on panoramic radiography (PAN) and cone-beam computed tomography (CBCT) images, and to study the impact of the image dataset on the treatment planning. Materials and Methods One hundred five partially edentulous patients (77 males, 28 females, mean age: 46 years, range: 26-67 years) seeking oral implant rehabilitation were referred for presurgical imaging. Imaging consisted of PAN and CBCT imaging. Four observers planned implant treatment based on the two-dimensional (2D) image datasets and at least one month later on the three-dimensional (3D) image dataset. Apart from presurgical diagnostic and dimensional measurement tasks, the observers needed to indicate the surgical confidence levels and assess the image quality in relation to the presurgical needs. Results All observers confirmed that both imaging modalities (PAN and CBCT) gave similar values when planning implant diameter. Also, the results showed no differences between both imaging modalities for the length of implants with an anterior location. However, significant differences were found in the length of implants with a posterior location. For implant dimensions, longer lengths of the implants were planned with PAN, as confirmed by two observers. CBCT provided images with improved scores for subjective image quality and surgical confidence levels. Conclusion Within the limitations of this study, there was a trend toward PAN-based preoperative planning of implant placement leading towards the use of longer implants within the posterior jaw bone. PMID:24944961

  10. The value of cone beam CT in assessing and managing a dilated odontome of a maxillary canine.

    PubMed

    Wall, Aoibheann; Ng, Suk; Djemal, Serpil

    2015-03-01

    A case of an unusual anomaly in a maxillary canine is described. A deep enamel invagination resulted in pulpal necrosis, longstanding infection and development of an associated radicular cyst. Diagnostic X-ray imaging was invaluable in demonstrating the complex root anatomy of the dilated odontome. In particular, a cone beam CT scan helped in the formulation of an appropriate treatment plan. Clinical Relevance: Three-dimensional imaging using cone beam CT was valuable in this case to demonstrate the complicated anatomy of a rare dental anomaly, and to help plan treatment. PMID:26058225

  11. Development of an optimization concept for arc-modulated cone beam therapy.

    PubMed

    Ulrich, Silke; Nill, Simeon; Oelfke, Uwe

    2007-07-21

    In this paper, we propose an optimization concept for a rotation therapy technique which is referred to as arc-modulated cone beam therapy (AMCBT). The aim is a reduction of the treatment time while achieving a treatment plan quality equal to or better than that of IMRT. Therefore, the complete dose is delivered in one single gantry rotation and the beam is modulated by a multileaf collimator. The degrees of freedom are the field shapes and weights for a predefined number of beam directions. In the new optimization loop, the beam weights are determined by a gradient algorithm and the field shapes by a tabu search algorithm. We present treatment plans for AMCBT for two clinical cases. In comparison to step-and-shoot IMRT treatment plans, it was possible by AMCBT to achieve dose distributions with a better dose conformity to the target and a lower mean dose for the most relevant organ at risk. Furthermore, the number of applied monitor units was reduced for AMCBT in comparison to IMRT treatment plans. PMID:17664597

  12. Inclusion of the dose from kilovoltage cone beam CT in the radiation therapy treatment plans

    SciTech Connect

    Alaei, Parham; Ding, George; Guan Huaiqun

    2010-01-15

    Purpose: Cone beam CT is increasingly being used for daily patient positioning verification during radiation therapy treatments. The daily use of CBCT could lead to accumulated patient doses higher than the older technique of weekly portal imaging. There have been several studies focusing on measurement or calculation of the patient dose from CBCT recently. Methods: This study investigates the feasibility of configuring a kV x-ray source in a commercial treatment planning system to calculate the dose to patient resulting from an IGRT procedure. The method proposed in this article can be used to calculate dose from CBCT imaging procedure and include that in the patient treatment plans. Results: The kilovoltage beam generated by the CBCT imager has been modeled using the planning system. The modeled profiles agree with the measured ones to within 5%. The modeled beam was used to calculate dose to phantom in the pelvic region and the calculations were compared to TLD measurements. The agreement between calculated and measured doses ranges from 0% to 19% in soft tissue with larger variations observed near and within the bone. Conclusions: The modeling of the beam produces reasonable results and the dose calculation comparisons indicate the potential for computing kilovoltage CBCT doses using a treatment planning system. Further improvements in the dose calculation algorithm are necessary, especially for dose calculations in and near the bone.

  13. 3D view weighted cone-beam backprojection reconstruction for digital tomosynthesis

    NASA Astrophysics Data System (ADS)

    Li, Baojun; Avinash, Gopal; Claus, Bernhard; Metz, Stephen

    2007-03-01

    Cone-beam filtered backprojection (CB-FBP) is one of the major reconstruction algorithms for digital tomosynthesis. In conventional FBP, the photon fluxes in projections are evenly distributed along the X-ray beam. Due to the limited view angles and finite detector dimensions, this uniform weighting causes non-uniformity in the recon images and leads to cone-beam artifact. In this paper, we propose a 3-D view weighting technique in combination with FBP to combat this artifact. An anthropomorphic chest phantom was placed at supine position to enable the imaging of chest PA view. During a linear sweep of X-ray source, 41 X-ray images at different projection angles were acquired with the following protocol: 120kVp, 160mA, and 0.64mAs/exposure. To create the worst scenario for testing, we chose 60 degrees as the sweep angle in this exam. The data set was reconstructed with conventional CB-FBP and proposed algorithm under the same parameters: FOV = 40x40 cm^2, and slice thickness = 4mm. 3 recon slices were randomly selected for review with slice height = 10.5/14.5/17.5cm. Results were assessed qualitatively by human observers and quantitatively through ROI measurement. In each slice, three pre-defined ROIs (50x50 pixels)--ROI A and B are in artifact more pronounced area, and ROI C is in relatively artifact-free area--are extracted and measured. The non-uniformity error was defined as the ratio of MEAN(AVG(C-A), AVG(C-B)) / AVG(C). The average non-uniformity error over the three test images was 0.428 for without view weighting and only 0.041 for with view weighting.

  14. Data consistency-driven scatter kernel optimization for x-ray cone-beam CT.

    PubMed

    Kim, Changhwan; Park, Miran; Sung, Younghun; Lee, Jaehak; Choi, Jiyoung; Cho, Seungryong

    2015-08-01

    Accurate and efficient scatter correction is essential for acquisition of high-quality x-ray cone-beam CT (CBCT) images for various applications. This study was conducted to demonstrate the feasibility of using the data consistency condition (DCC) as a criterion for scatter kernel optimization in scatter deconvolution methods in CBCT. As in CBCT, data consistency in the mid-plane is primarily challenged by scatter, we utilized data consistency to confirm the degree of scatter correction and to steer the update in iterative kernel optimization. By means of the parallel-beam DCC via fan-parallel rebinning, we iteratively optimized the scatter kernel parameters, using a particle swarm optimization algorithm for its computational efficiency and excellent convergence. The proposed method was validated by a simulation study using the XCAT numerical phantom and also by experimental studies using the ACS head phantom and the pelvic part of the Rando phantom. The results showed that the proposed method can effectively improve the accuracy of deconvolution-based scatter correction. Quantitative assessments of image quality parameters such as contrast and structure similarity (SSIM) revealed that the optimally selected scatter kernel improves the contrast of scatter-free images by up to 99.5%, 94.4%, and 84.4%, and of the SSIM in an XCAT study, an ACS head phantom study, and a pelvis phantom study by up to 96.7%, 90.5%, and 87.8%, respectively. The proposed method can achieve accurate and efficient scatter correction from a single cone-beam scan without need of any auxiliary hardware or additional experimentation. PMID:26183058

  15. Data consistency-driven scatter kernel optimization for x-ray cone-beam CT

    NASA Astrophysics Data System (ADS)

    Kim, Changhwan; Park, Miran; Sung, Younghun; Lee, Jaehak; Choi, Jiyoung; Cho, Seungryong

    2015-08-01

    Accurate and efficient scatter correction is essential for acquisition of high-quality x-ray cone-beam CT (CBCT) images for various applications. This study was conducted to demonstrate the feasibility of using the data consistency condition (DCC) as a criterion for scatter kernel optimization in scatter deconvolution methods in CBCT. As in CBCT, data consistency in the mid-plane is primarily challenged by scatter, we utilized data consistency to confirm the degree of scatter correction and to steer the update in iterative kernel optimization. By means of the parallel-beam DCC via fan-parallel rebinning, we iteratively optimized the scatter kernel parameters, using a particle swarm optimization algorithm for its computational efficiency and excellent convergence. The proposed method was validated by a simulation study using the XCAT numerical phantom and also by experimental studies using the ACS head phantom and the pelvic part of the Rando phantom. The results showed that the proposed method can effectively improve the accuracy of deconvolution-based scatter correction. Quantitative assessments of image quality parameters such as contrast and structure similarity (SSIM) revealed that the optimally selected scatter kernel improves the contrast of scatter-free images by up to 99.5%, 94.4%, and 84.4%, and of the SSIM in an XCAT study, an ACS head phantom study, and a pelvis phantom study by up to 96.7%, 90.5%, and 87.8%, respectively. The proposed method can achieve accurate and efficient scatter correction from a single cone-beam scan without need of any auxiliary hardware or additional experimentation.

  16. Small field dose delivery evaluations using cone beam optical computed tomography-based polymer gel dosimetry

    PubMed Central

    Olding, Timothy; Holmes, Oliver; DeJean, Paul; McAuley, Kim B.; Nkongchu, Ken; Santyr, Giles; Schreiner, L. John

    2011-01-01

    This paper explores the combination of cone beam optical computed tomography with an N-isopropylacrylamide (NIPAM)-based polymer gel dosimeter for three-dimensional dose imaging of small field deliveries. Initial investigations indicate that cone beam optical imaging of polymer gels is complicated by scattered stray light perturbation. This can lead to significant dosimetry failures in comparison to dose readout by magnetic resonance imaging (MRI). For example, only 60% of the voxels from an optical CT dose readout of a 1 l dosimeter passed a two-dimensional Low's gamma test (at a 3%, 3 mm criteria, relative to a treatment plan for a well-characterized pencil beam delivery). When the same dosimeter was probed by MRI, a 93% pass rate was observed. The optical dose measurement was improved after modifications to the dosimeter preparation, matching its performance with the imaging capabilities of the scanner. With the new dosimeter preparation, 99.7% of the optical CT voxels passed a Low's gamma test at the 3%, 3 mm criteria and 92.7% at a 2%, 2 mm criteria. The fitted interjar dose responses of a small sample set of modified dosimeters prepared (a) from the same gel batch and (b) from different gel batches prepared on the same day were found to be in agreement to within 3.6% and 3.8%, respectively, over the full dose range. Without drawing any statistical conclusions, this experiment gives a preliminary indication that intrabatch or interbatch NIPAM dosimeters prepared on the same day should be suitable for dose sensitivity calibration. PMID:21430853

  17. Algorithm for x-ray beam hardening and scatter correction in low-dose cone-beam CT: phantom studies

    NASA Astrophysics Data System (ADS)

    Liu, Wenlei; Rong, Junyan; Gao, Peng; Liao, Qimei; Lu, HongBing

    2016-03-01

    X-ray scatter poses a significant limitation to image quality in cone-beam CT (CBCT), as well as beam hardening, resulting in image artifacts, contrast reduction, and lack of CT number accuracy. Meanwhile the x-ray radiation dose is also non-ignorable. Considerable scatter or beam hardening correction methods have been developed, independently, and rarely combined with low-dose CT reconstruction. In this paper, we combine scatter suppression with beam hardening correction for sparse-view CT reconstruction to improve CT image quality and reduce CT radiation. Firstly, scatter was measured, estimated, and removed using measurement-based methods, assuming that signal in the lead blocker shadow is only attributable to x-ray scatter. Secondly, beam hardening was modeled by estimating an equivalent attenuation coefficient at the effective energy, which was integrated into the forward projector of the algebraic reconstruction technique (ART). Finally, the compressed sensing (CS) iterative reconstruction is carried out for sparse-view CT reconstruction to reduce the CT radiation. Preliminary Monte Carlo simulated experiments indicate that with only about 25% of conventional dose, our method reduces the magnitude of cupping artifact by a factor of 6.1, increases the contrast by a factor of 1.4 and the CNR by a factor of 15. The proposed method could provide good reconstructed image from a few view projections, with effective suppression of artifacts caused by scatter and beam hardening, as well as reducing the radiation dose. With this proposed framework and modeling, it may provide a new way for low-dose CT imaging.

  18. Cone Beam CT Image Guidance for Intracranial Stereotactic Treatments: Comparison With a Frame Guided Set-Up

    SciTech Connect

    Masi, Laura Casamassima, Franco; Polli, Caterina; Menichelli, Claudia; Bonucci, Ivano; Cavedon, Carlo

    2008-07-01

    Purpose: An analysis is performed of the setup errors measured by a kV cone beam computed tomography (CBCT) for intracranial stereotactic radiotherapy (SRT) patients immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. We evaluated the overall positioning precision and accuracy of the immobilizing and localizing systems. The potential of image-guided radiotherapy to replace stereotactic methods is discussed. Methods and Materials: Fifty-seven patients received brain SRT. After a frame-guided setup, before each fraction (131 fractions), a CBCT was acquired and the detected displacements corrected online. Translational and rotational errors were analyzed calculating overall mean and standard deviation. A separate analysis was performed for bite-block (in conjunction with mask) and for simple thermoplastic mask. Interobserver variability for CBCT three-dimensional registration was assessed. The residual error after correction and intrafractional motion were calculated. Results: The mean module of the three-dimensional displacement vector was 3.0 {+-} 1.4 mm. Setup errors for bite block and mask were smaller (2.9 {+-} 1.3 mm) than those for thermoplastic mask alone (3.2 {+-} 1.5 mm), but statistical significance was not reached (p = 0.15). Interobserver variability was negligible. The maximum margin calculated for residual errors and intra fraction motion was small but not negligible (1.57 mm). Conclusions: Considering the detected setup errors, daily image guidance is essential for the efficacy of SRT treatments when mask immobilization is used, and even when a bite-block is used in conjunction. The frame setup is still used as a starting point for the opportunity of rotational corrections. Residual margins after on-line corrections must be evaluated.

  19. Accurate patient dosimetry of kilovoltage cone-beam CT in radiation therapy

    SciTech Connect

    Ding, George X.; Duggan, Dennis M.; Coffey, Charles W.

    2008-03-15

    The increased utilization of x-ray imaging in image-guided radiotherapy has dramatically improved the radiation treatment and the lives of cancer patients. Daily imaging procedures, such as cone-beam computed tomography (CBCT), for patient setup may significantly increase the dose to the patient's normal tissues. This study investigates the dosimetry from a kilovoltage (kV) CBCT for real patient geometries. Monte Carlo simulations were used to study the kV beams from a Varian on-board imager integrated into the Trilogy accelerator. The Monte Carlo calculated results were benchmarked against measurements and good agreement was obtained. The authors developed a novel method to calibrate Monte Carlo simulated beams with measurements using an ionization chamber in which the air-kerma calibration factors are obtained from an Accredited Dosimetry Calibration Laboratory. The authors have introduced a new Monte Carlo calibration factor, f{sub MCcal}, which is determined from the calibration procedure. The accuracy of the new method was validated by experiment. When a Monte Carlo simulated beam has been calibrated, the simulated beam can be used to accurately predict absolute dose distributions in the irradiated media. Using this method the authors calculated dose distributions to patient anatomies from a typical CBCT acquisition for different treatment sites, such as head and neck, lung, and pelvis. Their results have shown that, from a typical head and neck CBCT, doses to soft tissues, such as eye, spinal cord, and brain can be up to 8, 6, and 5 cGy, respectively. The dose to the bone, due to the photoelectric effect, can be as much as 25 cGy, about three times the dose to the soft tissue. The study provides detailed information on the additional doses to the normal tissues of a patient from a typical kV CBCT acquisition. The methodology of the Monte Carlo beam calibration developed and introduced in this study allows the user to calculate both relative and absolute

  20. A local shift-variant Fourier model and experimental validation of circular cone-beam computed tomography artifacts.

    PubMed

    Bartolac, Steven; Clackdoyle, Roll; Noo, Frederic; Siewerdsen, Jeff; Moseley, Douglas; Jaffray, David

    2009-02-01

    Large field of view cone-beam computed tomography (CBCT) is being achieved using circular source and detector trajectories. These circular trajectories are known to collect insufficient data for accurate image reconstruction. Although various descriptions of the missing information exist, the manifestation of this lack of data in reconstructed images is generally nonintuitive. One model predicts that the missing information corresponds to a shift-variant cone of missing frequency components. This description implies that artifacts depend on the imaging geometry, as well as the frequency content of the imaged object. In particular, objects with a large proportion of energy distributed over frequency bands that coincide with the missing cone will be most compromised. These predictions were experimentally verified by imaging small, localized objects (acrylic spheres, stacked disks) at varying positions in the object space and observing the frequency spectrums of the reconstructions. Measurements of the internal angle of the missing cone agreed well with theory, indicating a right circular cone for points on the rotation axis, and an oblique, circular cone elsewhere. In the former case, the largest internal angle with respect to the vertical axis corresponds to the (half) cone angle of the CBCT system (typically approximately 5 degrees - 7.5 degrees in IGRT). Object recovery was also found to be strongly dependent on the distribution of the object's frequency spectrum relative to the missing cone, as expected. The observed artifacts were also reproducible via removal of local frequency components, further supporting the theoretical model. Larger objects with differing internal structures (cellular polyurethane, solid acrylic) were also imaged and interpreted with respect to the previous results. Finally, small animal data obtained using a clinical CBCT scanner were observed for evidence of the missing cone. This study provides insight into the influence of incomplete

  1. A local shift-variant Fourier model and experimental validation of circular cone-beam computed tomography artifacts

    PubMed Central

    Bartolac, Steven; Clackdoyle, Rolf; Noo, Frederic; Siewerdsen, Jeff; Moseley, Douglas; Jaffray, David

    2009-01-01

    Large field of view cone-beam computed tomography (CBCT) is being achieved using circular source and detector trajectories. These circular trajectories are known to collect insufficient data for accurate image reconstruction. Although various descriptions of the missing information exist, the manifestation of this lack of data in reconstructed images is generally nonintuitive. One model predicts that the missing information corresponds to a shift-variant cone of missing frequency components. This description implies that artifacts depend on the imaging geometry, as well as the frequency content of the imaged object. In particular, objects with a large proportion of energy distributed over frequency bands that coincide with the missing cone will be most compromised. These predictions were experimentally verified by imaging small, localized objects (acrylic spheres, stacked disks) at varying positions in the object space and observing the frequency spectrums of the reconstructions. Measurements of the internal angle of the missing cone agreed well with theory, indicating a right circular cone for points on the rotation axis, and an oblique, circular cone elsewhere. In the former case, the largest internal angle with respect to the vertical axis corresponds to the (half) cone angle of the CBCT system (typically ∼5°–7.5° in IGRT). Object recovery was also found to be strongly dependent on the distribution of the object’s frequency spectrum relative to the missing cone, as expected. The observed artifacts were also reproducible via removal of local frequency components, further supporting the theoretical model. Larger objects with differing internal structures (cellular polyurethane, solid acrylic) were also imaged and interpreted with respect to the previous results. Finally, small animal data obtained using a clinical CBCT scanner were observed for evidence of the missing cone. This study provides insight into the influence of incomplete data collection on the

  2. Analytic method based on identification of ellipse parameters for scanner calibration in cone-beam tomography.

    PubMed

    Noo, F; Clackdoyle, R; Mennessier, C; White, T A; Roney, T J

    2000-11-01

    This paper is about calibration of cone-beam (CB) scanners for both x-ray computed tomography and single-photon emission computed tomography. Scanner calibration refers here to the estimation of a set of parameters which fully describe the geometry of data acquisition. Such parameters are needed for the tomographic reconstruction step. The discussion is limited to the usual case where the cone vertex and planar detector move along a circular path relative to the object. It is also assumed that the detector does not have spatial distortions. We propose a new method which requires a small set of measurements of a simple calibration object consisting of two spherical objects, that can be considered as 'point' objects. This object traces two ellipses on the detector and from the parametric description of these ellipses, the calibration geometry can be determined analytically using explicit formulae. The method is robust and easy to implement. However, it is not fully general as it is assumed that the detector is parallel to the rotation axis of the scanner. Implementation details are given for an experimental x-ray CB scanner. PMID:11098919

  3. Dynamics of high-energy proton beam acceleration and focusing from hemisphere-cone targets by high-intensity lasers.

    PubMed

    Qiao, B; Foord, M E; Wei, M S; Stephens, R B; Key, M H; McLean, H; Patel, P K; Beg, F N

    2013-01-01

    Acceleration and focusing of high-energy proton beams from fast-ignition (FI) -related hemisphere-cone assembled targets have been numerically studied by hybrid particle-in-cell simulations and compared with those from planar-foil and open-hemisphere targets. The whole physical process including the laser-plasma interaction has been self-consistently modeled for 15 ps, at which time the protons reach asymptotic motion. It is found that the achievable focus of proton beams is limited by the thermal pressure gradients in the co-moving hot electrons, which induce a transverse defocusing electric field that bends proton trajectories near the axis. For the advanced hemisphere-cone target, the flow of hot electrons along the cone wall induces a local transverse focusing sheath field, resulting in a clear enhancement in proton focusing; however, it leads to a significant loss of longitudinal sheath potential, reducing the total conversion efficiency from laser to protons. PMID:23410447

  4. Cone Beam Computed Tomography (CBCT) in the Field of Interventional Oncology of the Liver.

    PubMed

    Bapst, Blanche; Lagadec, Matthieu; Breguet, Romain; Vilgrain, Valérie; Ronot, Maxime

    2016-01-01

    Cone beam computed tomography (CBCT) is an imaging modality that provides computed tomographic images using a rotational C-arm equipped with a flat panel detector as part of the Angiography suite. The aim of this technique is to provide additional information to conventional 2D imaging to improve the performance of interventional liver oncology procedures (intraarterial treatments such as chemoembolization or selective internal radiation therapy, and percutaneous tumor ablation). CBCT provides accurate tumor detection and targeting, periprocedural guidance, and post-procedural evaluation of treatment success. This technique can be performed during intraarterial or intravenous contrast agent administration with various acquisition protocols to highlight liver tumors, liver vessels, or the liver parenchyma. The purpose of this review is to present an extensive overview of published data on CBCT in interventional oncology of the liver, for both percutaneous ablation and intraarterial procedures. PMID:26178776

  5. Unilateral Fusion of Maxillary Lateral Incisor: Diagnosis Using Cone Beam Computed Tomography

    PubMed Central

    Castro, Iury Oliveira; Estrela, Carlos; Souza, Vinícius Rezende; Lopes, Lawrence Gonzaga; de Souza, João Batista

    2014-01-01

    Objective. The objective of this paper is to report a dental fusion case focusing on clinical and radiographic features for the diagnosis. Method. To report a case of right maxillary lateral incisor fusion and a supernumerary tooth, the anatomy of the root canal and dental united portion were assessed by cone beam computed tomography (CBCT). Results. The clinical examination showed dental juxtaposition with the absence of interdental papilla and esthetic impairment in the right maxillary lateral incisor region. The periapical radiography did not provide enough information for the differential diagnosis due to the inherent limitations of this technique. CBCT confirmed the presence of tooth fusion. Conclusion. CBCT examination supports the diagnosis and provides both the identification of changes in tooth development and the visualization of their extent and limits. PMID:25587463

  6. Geometric Parameters Estimation and Calibration in Cone-Beam Micro-CT.

    PubMed

    Zhao, Jintao; Hu, Xiaodong; Zou, Jing; Hu, Xiaotang

    2015-01-01

    The quality of Computed Tomography (CT) images crucially depends on the precise knowledge of the scanner geometry. Therefore, it is necessary to estimate and calibrate the misalignments before image acquisition. In this paper, a Two-Piece-Ball (TPB) phantom is used to estimate a set of parameters that describe the geometry of a cone-beam CT system. Only multiple projections of the TPB phantom at one position are required, which can avoid the rotation errors when acquiring multi-angle projections. Also, a corresponding algorithm is derived. The performance of the method is evaluated through simulation and experimental data. The results demonstrated that the proposed method is valid and easy to implement. Furthermore, the experimental results from the Micro-CT system demonstrate the ability to reduce artifacts and improve image quality through geometric parameter calibration. PMID:26371008

  7. A Diagnosis of Maxillary Sinus Fracture with Cone-Beam CT: Case Report and Literature Review

    PubMed Central

    Yilmaz, Selmi Yardimci; Misirlioglu, Melda; Adisen, Mehmet Zahit

    2014-01-01

    The purpose of this article is to present the case of maxillofacial trauma patient with maxillary sinus fracture diagnosed with cone-beam computed tomography (CBCT) and to explore the applications of this technique in evaluating the maxillofacial region. A 23-year-old male patient attempted to our clinic who had an injury at midface with complaints of swelling, numbness. The patient was examined before in emergency center but any diagnosis was made about the maxillofacial trauma. The patient re-examined clinically and radiographically. A fracture on the frontal wall of maxillary sinus is determined with the aid of CBCT. The patient consulted with the department of maxillofacial surgery and it is decided that any surgical treatment was not necessary. The emerging technique CBCT would not be the primary choice of imaging maxillofacial trauma. Nevertheless, when advantages considered this imaging procedure could be the modality of choice according to the case. PMID:25045417

  8. Practical geometric calibration for helical cone-beam industrial computed tomography.

    PubMed

    Zhang, Feng; Yan, Bin; Li, Lei; Xi, Xiaoqi; Jiang, Hua

    2014-01-01

    In helical cone-beam industrial computed tomography (ICT), the reconstructed images may be interfered by geometry artifacts due to the presence of mechanical misalignments. To obtain artifact-free reconstruction images, a practical geometric calibration method for helical scan is investigated based on Noo's analytic geometric calibration method for circular scan. The presented method is implemented by first dividing the whole ascending path of helical scan into several pieces, then acquiring the projections of a dedicated calibration phantom in circular scan at each section point, of which geometry parameters are calculated using Noo's analytic method. At last, the geometry parameters of each projection in a piece can be calculated by those of the two end points of the piece. We performed numerical simulations and real data experiments to study the performance of the presented method. The experimental results indicated that the method can obtain high-precision geometry parameters of helical scan and give satisfactory reconstruction images. PMID:24463383

  9. Cone Beam Computed Tomography Findings in Calcifying Cystic Odontogenic Tumor Associated with Odontome: A Case Report

    PubMed Central

    Phulambrikar, Tushar; Vilas Kant, Sanchita; Kode, Manasi; Magar, Shaliputra

    2015-01-01

    The calcifying cystic odontogenic tumor (CCOT) is a rare cystic odontogenic neoplasm frequently found in association with odontome. This report documents a case of CCOT associated with an odontome arising in the anterior maxilla in a 28-year-old man. Conventional radiographs showed internal calcification within the lesion but were unable to visualize its relation with the adjacent structures and its accurate extent. In this case cone beam computed tomography (CBCT) could accurately reveal the extent and the internal structure of the lesion which aided the presumptive diagnosis of the lesion as CCOT. This advanced imaging technique proved to be extremely useful in the radiographic assessment and management of this neoplasm of the maxilla. PMID:26636128

  10. Excitation-resolved cone-beam x-ray luminescence tomography

    NASA Astrophysics Data System (ADS)

    Liu, Xin; Liao, Qimei; Wang, Hongkai; Yan, Zhuangzhi

    2015-07-01

    Cone-beam x-ray luminescence computed tomography (CB-XLCT), as an emerging imaging technique, plays an important role in in vivo small animal imaging studies. However, CB-XLCT suffers from low-spatial resolution due to the ill-posed nature of reconstruction. We improve the imaging performance of CB-XLCT by using a multiband excitation-resolved imaging scheme combined with principal component analysis. To evaluate the performance of the proposed method, the physical phantom experiment is performed with a custom-made XLCT/XCT imaging system. The experimental results validate the feasibility of the method, where two adjacent nanophosphors (with an edge-to-edge distance of 2.4 mm) can be located.

  11. Patient radiation dose and protection from cone-beam computed tomography

    PubMed Central

    2013-01-01

    After over one decade development, cone beam computed tomography (CBCT) has been widely accepted for clinical application in almost every field of dentistry. Meanwhile, the radiation dose of CBCT to patient has also caused broad concern. According to the literature, the effective radiation doses of CBCTs in nowadays market fall into a considerably wide range that is from 19 µSv to 1073 µSv and closely related to the imaging detector, field of view, and voxel sizes used for scanning. To deeply understand the potential risk from CBCT, this report also reviewed the effective doses from literatures on intra-oral radiograph, panoramic radiograph, lateral and posteroanterior cephalometric radiograph, multi-slice CT, and so on. The protection effect of thyroid collar and leaded glasses were also reviewed. PMID:23807928

  12. Computer aided breast calcification auto-detection in cone beam breast CT

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaohua; Ning, Ruola; Liu, Jiangkun

    2010-03-01

    In Cone Beam Breast CT (CBBCT), breast calcifications have higher intensities than the surrounding tissues. Without the superposition of breast structures, the three-dimensional distribution of the calcifications can be revealed. In this research, based on the fact that calcifications have higher contrast, a local thresholding and a histogram thresholding were used to select candidate calcification areas. Six features were extracted from each candidate calcification: average foreground CT number value, foreground CT number standard deviation, average background CT number value, background CT number standard deviation, foreground-background contrast, and average edge gradient. To reduce the false positive candidate calcifications, a feed-forward back propagation artificial neural network was designed. The artificial neural network was trained with the radiologists confirmed calcifications and used as classifier in the calcification auto-detection task. In the preliminary experiments, 90% of the calcifications in the testing data sets were detected correctly with an average of 10 false positives per data set.

  13. Multiple idiopathic external and internal resorption: Case report with cone-beam computed tomography findings

    PubMed Central

    Uzuntas, Ceren Feriha; Kurt, Hakan

    2014-01-01

    Root resorption is loss of dental hard tissue as a result of clastic activities. The dental hard tissue of permanent teeth does not normally undergo resorption, except in cases of inflammation or trauma. However, there are rare cases of tooth resorption of an unknown cause, known as "idiopathic root resorption." This report would discuss a rare case of multiple idiopathic resorption in the permanent maxillary and mandibular teeth of an otherwise healthy 36-year-old male patient. In addition to a clinical examination, the patient was imaged using conventional radiography and cone-beam computed tomography (CBCT). The examinations revealed multiple external and internal resorption of the teeth in all four quadrants of the jaws with an unknown cause. Multiple root resorption is a rare clinical phenomenon that should be examined using different radiographic modalities. Cross-sectional CBCT is useful in the diagnosis and examination of such lesions. PMID:25473640

  14. Cone Beam Computed Tomographic Evaluation and Diagnosis of Mandibular First Molar with 6 Canals

    PubMed Central

    Pasha, Shiraz; Chaitanya, Bathula Vimala; Somisetty, Kusum Valli

    2016-01-01

    Root canal treatment of tooth with aberrant root canal morphology is very challenging. So thorough knowledge of both the external and internal anatomy of teeth is an important aspect of root canal treatment. With the advancement in technology it is imperative to use modern diagnostic tools such as magnification devices, CBCT, microscopes, and RVG to confirm the presence of these aberrant configurations. However, in everyday endodontic practice, clinicians have to treat teeth with atypical configurations for root canal treatment to be successful. This case report presents the management of a mandibular first molar with six root canals, four in mesial and two in distal root, and also emphasizes the use and importance of Cone Beam Computed Tomography (CBCT) as a diagnostic tool in endodontics. PMID:26904310

  15. Role of C-Arm Cone-Beam CT in Chemoembolization for Hepatocellular Carcinoma

    PubMed Central

    2015-01-01

    With the advent of C-arm cone-beam computed tomography (CBCT), minimally-invasive procedures in the angiography suite made a new leap beyond the limitations of 2-dimensional (D) angiography alone. C-arm CBCT can help interventional radiologists in several ways with the treatment of hepatocellular carcinoma (HCC); visualization of small tumors and tumor-feeding arteries, identification of occult lesion and 3D configuration of tortuous hepatic arteries, assurance of completeness of chemoembolization, suggestion of presence of extrahepatic collateral arteries supplying HCCs, and prevention of nontarget embolization. With more improvements in the technology, C-arm CBCT may be essential in all kinds of interventional procedures in the near future. PMID:25598679

  16. Rare Root Canal Configuration of Bilateral Maxillary Second Molar Using Cone-beam Computed Tomographic Scanning.

    PubMed

    Zeng, Chang; Shen, Ya; Guan, Xiaoyue; Wang, Xin; Fan, Mingwen; Li, Yuhong

    2016-04-01

    The aim of this article was to present a right maxillary second molar with an unusual root canal morphology of 4 roots and 5 canals as confirmed by cone-beam computed tomographic (CBCT) imaging. The tooth had a C-shaped mesiobuccal root (CBCT imaging revealed that the root was closer to the palate than the buccal side) with 2 canals, 2 fused distobuccal roots with 2 separate canals, and 1 normal bulky palatal root with 1 canal. After thoroughly examining the rare anatomy, root canal treatment was applied on the tooth. This article shows the complexity of maxillary second molar variation and shows the significance of CBCT imaging in the confirmation of the 3-dimensional anatomy of teeth and endodontic treatment. PMID:26920931

  17. Cone-beam computed tomography exploration and surgical management of palatal, inverted, and impacted mesiodens

    PubMed Central

    Omami, Mounir; Chokri, Abdellatif; Hentati, Hajer; Selmi, Jamil

    2015-01-01

    Supernumerary teeth are extra teeth or toothlike structures which may have either erupted or unerupted in addition to the 20 deciduous teeth and the 32 permanent teeth. Mesiodens is one of these located in the midline between the two central incisors. Their presence may give rise to a variety of clinical problems. This paper describes a rare case of palatal placed, inverted and impacted mesiodens associated to two supernumerary teeth which were detected during a radiographic examination for delayed eruption of permanent central incisors in the case of a healthy 8-year-old girl monitored at the oral surgery service while discussing the usefulness of cone beam computed tomography for accurate diagnosis and management. PMID:26604591

  18. Endodontic management of mandibular first molar with seven canals using cone-beam computed tomography.

    PubMed

    Banode, Ankur Mahesh; Gade, Vandana; Patil, Sanjay; Gade, Jaykumar

    2016-01-01

    The endodontic treatment of a mandibular molar with aberrant canal configuration can be diagnostically and clinically challenging. Successful endodontic therapy thus depends on the clinician's ability to anticipate and look for these aberrant variations. A mandibular first molar with seven canals represents a rare anatomical variant, particularly when four canals are found in distal root. Based on in vitro studies, its incidence is reported to be between 0.2% and 3%. With the advent of cone-beam computed tomography (CBCT) as an adjunctive diagnostic aid, the determination of root canal anatomy in teeth with complex canal configurations has become more precise. The present case report discusses successful nonsurgical management of radix entomolaris along with middle mesial canal and middle distal canal in mandibular first molar with seven canals (four canals in distal and three in mesial) employing CBCT as an adjunctive diagnostic aid to conventional radiography. PMID:27307680

  19. Rare appearance of an odontogenic myxoma in cone-beam computed tomography: a case report

    PubMed Central

    Dabbaghi, Arash; Nikkerdar, Nafiseh; Bayati, Soheyla; Golshah, Amin

    2016-01-01

    Odontogenic myxoma (OM) is an infiltrative benign bone tumor that occurs almost exclusively in the facial skeleton. The radiographic characteristics of odontogenic myxoma may produce several patterns, making diagnosis difficult. Cone-beam computed tomography (CBCT) may prove extremely useful in clarifying the intraosseous extent of the tumor and its effects on surrounding structures. Here, we report a case of odontogenic myxoma of the mandible in a 27-year-old female. The patient exhibited a slight swelling in the left mandible. Surgical resection was performed. No recurrence was noted. In the CBCT sections, we observed perforation of the cortical plate and radiopaque line that extended from the periosteum, resembling "sunray" appearance—a rare feature of OM—which could not be assessed by panoramic radiography. PMID:27092217

  20. Rare appearance of an odontogenic myxoma in cone-beam computed tomography: a case report.

    PubMed

    Dabbaghi, Arash; Nikkerdar, Nafiseh; Bayati, Soheyla; Golshah, Amin

    2016-01-01

    Odontogenic myxoma (OM) is an infiltrative benign bone tumor that occurs almost exclusively in the facial skeleton. The radiographic characteristics of odontogenic myxoma may produce several patterns, making diagnosis difficult. Cone-beam computed tomography (CBCT) may prove extremely useful in clarifying the intraosseous extent of the tumor and its effects on surrounding structures. Here, we report a case of odontogenic myxoma of the mandible in a 27-year-old female. The patient exhibited a slight swelling in the left mandible. Surgical resection was performed. No recurrence was noted. In the CBCT sections, we observed perforation of the cortical plate and radiopaque line that extended from the periosteum, resembling "sunray" appearance-a rare feature of OM-which could not be assessed by panoramic radiography. PMID:27092217

  1. Geometric Parameters Estimation and Calibration in Cone-Beam Micro-CT

    PubMed Central

    Zhao, Jintao; Hu, Xiaodong; Zou, Jing; Hu, Xiaotang

    2015-01-01

    The quality of Computed Tomography (CT) images crucially depends on the precise knowledge of the scanner geometry. Therefore, it is necessary to estimate and calibrate the misalignments before image acquisition. In this paper, a Two-Piece-Ball (TPB) phantom is used to estimate a set of parameters that describe the geometry of a cone-beam CT system. Only multiple projections of the TPB phantom at one position are required, which can avoid the rotation errors when acquiring multi-angle projections. Also, a corresponding algorithm is derived. The performance of the method is evaluated through simulation and experimental data. The results demonstrated that the proposed method is valid and easy to implement. Furthermore, the experimental results from the Micro-CT system demonstrate the ability to reduce artifacts and improve image quality through geometric parameter calibration. PMID:26371008

  2. Phase Contrast Cone Beam Tomography with an X-Ray Grating Interferometer

    NASA Astrophysics Data System (ADS)

    Jerjen, I.; Revol, V.; Kottler, C.; Luethi, Th.; Sennhauser, U.; Kaufmann, R.; Urban, C.

    2010-04-01

    We report on our recent developments of reconstruction algorithms for Differential Phase Contrast X-ray Computed Tomography (DPC CT). DPC images provide information about the real and imaginary part of the refractive index which is an advantage when objects with poor absorption but good phase contrast are inspected. In order to promote DPC CT for industrial applications we developed an adapted Feldkamp algorithm which allows reconstructing the three-dimensional image of the refractive index of an object from the DPC projections obtained with our large field of view, high energy grating interferometer set up in a cone beam geometry. We present slice images of a test object and show different ways of visualization of the phase and absorption information.

  3. Endodontic management of mandibular first molar with seven canals using cone-beam computed tomography

    PubMed Central

    Banode, Ankur Mahesh; Gade, Vandana; Patil, Sanjay; Gade, Jaykumar

    2016-01-01

    The endodontic treatment of a mandibular molar with aberrant canal configuration can be diagnostically and clinically challenging. Successful endodontic therapy thus depends on the clinician's ability to anticipate and look for these aberrant variations. A mandibular first molar with seven canals represents a rare anatomical variant, particularly when four canals are found in distal root. Based on in vitro studies, its incidence is reported to be between 0.2% and 3%. With the advent of cone-beam computed tomography (CBCT) as an adjunctive diagnostic aid, the determination of root canal anatomy in teeth with complex canal configurations has become more precise. The present case report discusses successful nonsurgical management of radix entomolaris along with middle mesial canal and middle distal canal in mandibular first molar with seven canals (four canals in distal and three in mesial) employing CBCT as an adjunctive diagnostic aid to conventional radiography. PMID:27307680

  4. Responsible use of cone beam computed tomography: minimising medico-legal risks.

    PubMed

    Noffke, C E E; Farman, A G; Van der Linde, A; Nel, S

    2013-07-01

    This communication highlights some of the ethical and possible legal responsibilities which pertain to the taking, reading, reporting, and communication of findings from cone-beam computed tomography (CBCT) scans. The importance of knowledge of head and neck anatomy and pathology to reduce the likelihood of incorrect interpretation is emphasised. Failure to detect critical findings in any diagnostic image can potentially result in medico-legal consequences. CBCT is no exception to this rule. Dental schools are advised to include CBCT imaging as a diagnostic tool in their under- and postgraduate curricula thereby equipping graduates to use 3D imaging in general and CBCT in particular. Existing dental practitioners are advised to seek continuing education on 3D imaging as part of their required lifelong learning. PMID:23971277

  5. Fully-deformable patient motion models from cone-beam CT for radiotherapy applications

    NASA Astrophysics Data System (ADS)

    Martin, J.; McClelland, J.; Yip, C.; Thomas, C.; Hartill, C.; Ahmad, S.; Meir, I.; Landau, D.; Hawkes, D.

    2014-03-01

    We propose a method to build a fully deformable motion model directly from cone-beam CT (CBCT) projections. This allows inter-fraction variations in the respiratory motion to be accounted for. It is envisaged that the model be used to track the tumour, and monitor organs at risk (OAR), during gated or tracked radiotherapy (RT) treatment of lung cancer. The method is tested on CBCT projections from a simulated phantom in two cases. The simulations are generated from a patient respiratory trace and associated CBCT scanner geometry. Without and with motion correction, l2 norm maximum errors were reduced from 24.5 to 0.698 mm in case 1, and 20.0 to 0.101 mm in case 2, respectively.

  6. Development of Kilovoltage X-ray Dosimetry Methods and Their Application to Cone Beam Computed Tomography

    NASA Astrophysics Data System (ADS)

    Lawless, Michael J.

    The increase in popularity of pre-treatment imaging procedures in radiation therapy, such as kilovoltage cone beam computed tomography (CBCT), has been accompanied by an increase in the dose delivered to the patient from these imaging procedures. The measurement of dose from CBCT scans is complicated, as currently available kilovoltage dosimetry protocols are based on air-kerma standards and radiation detectors exhibit large energy responses at the low photon energies used in the imaging procedures. This work aims to provide the tools and methodology needed to measure the dose from these scans more accurately and precisely. Through the use of a validated Monte Carlo (MC) model of the moderately filtered (M-series) x-ray beams at the University of Wisconsin Accredited Dosimetry Calibration Laboratory, dose-to-water rates were obtained in a water phantom for the M-series x-ray beams with tube potentials from 40-250 kVp. The resulting dose-to-water rates were consistent with previously established methods, but had significantly reduced uncertainties. While detectors are commonly used to measure dose in phantom, previous investigations of the energy response of common detectors in the kilovoltage energy range have been limited to in-air geometries. The newly determined dose-to-water rates were used to characterize the in-phantom energy and depth response of thermoluminescent dosimeters and ionization chambers. When compared to previous investigations of the in-air detector response, the impact of scatter and absorption of the photon beam by the water medium was found to have a significant impact on the response of certain detectors. The dose to water in the NIST-traceable M-series x-ray beams was transferred to clinical CBCT beams and the resulting doses agreed with other dose-to-water measurement techniques. The dose to water in the CBCT beams was used to characterize the energy and depth responses of a number of detectors. The energy response in the CBCT beams agreed

  7. Case History Report: Cone Beam Computed Tomography for Implant Insertion Guidance in the Presence of a Dense Bone Island.

    PubMed

    Li, Ze-jian; Lai, Ren-fa; Feng, Zhi-qiang

    2016-01-01

    This article describes the use of cone beam computed tomography (CBCT) to diagnose a dense bone island (DBI) to facilitate implant insertion guidance in a patient followed up for 4 years. Suitable image-directed preplanning and periodic review by CBCT scanning is recommended when a jaw DBI is encountered in treatment planning for implant placement. PMID:26929962

  8. Detection of cavitated approximal surfaces using cone beam CT and intraoral receptors

    PubMed Central

    Wenzel, A; Hirsch, E; Christensen, J; Matzen, L H; Scaf, G; Frydenberg, M

    2013-01-01

    Objectives The aim of this study was to compare cone beam CT (CBCT) in a small field of view (FOV) with a solid-state sensor and a photostimulable phosphor plate system for detection of cavitated approximal surfaces. Methods 257 non-filled approximal surfaces from human permanent premolars and molars were recorded by two intraoral digital receptors, a storage phosphor plate (Digora Optime, Soredex) and a solid-state CMOS sensor (Digora Toto, Soredex), and scanned in a cone beam CT unit (3D Accuitomo FPD80, Morita) with a FOV of 4 cm and a voxel size of 0.08 mm. Image sections were carried out in the axial and mesiodistal tooth planes. Six observers recorded surface cavitation in all images. Validation of the true absence or presence of surface cavitation was performed by inspecting the surfaces under strong light with the naked eye. Differences in sensitivity, specificity and agreement were estimated by analysing the binary data in a generalized linear model using an identity link function. Results : A significantly higher sensitivity was obtained by all observers with CBCT (p < 0.001), which was not compromised by a lower specificity. Therefore, a significantly higher overall agreement was obtained with CBCT (p < 0.001). There were no significant differences between the Digora Optime phosphor plate system and the Digora Toto CMOS sensor for any parameter. Conclusions CBCT was much more accurate in the detection of surface cavitation in approximal surfaces than intraoral receptors. The differences are interpreted as clinically significant. A CBCT examination performed for other reasons should also be assessed for approximal surface cavities in teeth without restorations.

  9. Evaluation of Radiation Dose and Image Quality for the Varian Cone Beam Computed Tomography System

    SciTech Connect

    Cheng, Harry C.Y.; Wu, Vincent W.C.; Liu, Eva S.F.; Kwong, Dora L.W.

    2011-05-01

    Purpose: To compare the image quality and dosimetry on the Varian cone beam computed tomography (CBCT) system between software Version 1.4.13 and Version 1.4.11 (referred to as 'new' and 'old' protocols, respectively, in the following text). This study investigated organ absorbed dose, total effective dose, and image quality of the CBCT system for the head-and-neck and pelvic regions. Methods and Materials: A calibrated Farmer chamber and two standard cylindrical Perspex CT dosimetry phantoms with diameter of 16 cm (head phantom) and 32 cm (body phantom) were used to measure the weighted cone-beam computed tomography dose index (CBCTDIw) of the Varian CBCT system. The absorbed dose of different organs was measured in a female anthropomorphic phantom with thermoluminescent dosimeters (TLD) and the total effective dose was estimated according to International Commission on Radiological Protection (ICRP) Publication 103. The dose measurement and image quality were studied for head-and-neck and pelvic regions, and comparison was made between the new and old protocols. Results: The values of the new CBCTDIw head-and-neck and pelvic protocols were 36.6 and 29.4 mGy, respectively. The total effective doses from the new head-and-neck and pelvic protocols were 1.7 and 8.2 mSv, respectively. The absorbed doses of lens for the new 200{sup o} and old 360{sup o} head-and-neck protocols were 3.8 and 59.4 mGy, respectively. The additional secondary cancer risk from daily CBCT might be up to 2.8%. Conclusions: The new Varian CBCT provided volumetric information for image guidance with acceptable image quality and lower radiation dose. This imaging tool gave a better standard for patient daily setup verification.

  10. Anatomical and Morphological Characterization of the Nasopalatine Canal: A Cone-Beam Computed Tomography Study.

    PubMed

    Rodricks, D; Gupta, A; Phulambrikar, T; Singh, S K; Sharma, B K; Agrawal, P

    2016-04-01

    The anterior maxilla, also called pre-maxilla, is an area frequently requiring surgical interventions. Rehabilitation of this area remains a complex restorative challenge. The most prominent anatomical structure within the anterior maxilla is the Nasopalatine Canal. Thorough knowledge about this anatomical structure plays an important role in the successful outcomes of surgical procedures. This retrospective study was done to evaluate the anatomy and morphology of the Nasopalatine Canal using cone-beam computed tomography (CBCT). The study included 125 subjects aged between 15 and 78 years who were divided into the following 5 groups: i) 15-30 years, ii) 30-45 years, iii) 45-60 years, iv) 60-75 years, v) ≥75 years in the Department of Oral Medicine & Radiology, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India from January 2012 to January 2015. Cone-beam computed tomography (CBCT) was performed using a standard exposure and patient positioning protocol. The data of the CBCT images were sliced in three dimensions. Image planes on the three axes (X, Y, and Z) were sequentially analyzed for the location, morphology and dimensions of the Nasopalatine Canal. The correlation of age and gender with all the variables were evaluated. ANOVA and Z-test was used. P value <0.05 was considered statistically significant. Males and females showed significant differences in the length of the canal and anterior bone width in the sagittal sections. Inverted L was identified as a new dimension to the morphological shape of Nasopalatine Canal in central Madhya Pradesh population. The present study highlighted important variability observed in the anatomy and morphology of the Nasopalatine Canal. PMID:27277370