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Sample records for ou por moagem

  1. Tunable, nonlinear Hong-Ou-Mandel interferometer

    NASA Astrophysics Data System (ADS)

    Oehri, D.; Pletyukhov, M.; Gritsev, V.; Blatter, G.; Schmidt, S.

    2015-03-01

    We investigate the two-photon scattering properties of a Jaynes-Cummings (JC) nonlinearity consisting of a two-level system (qubit) interacting with a single-mode cavity, which is coupled to two waveguides, each containing a single incident photon wave packet initially. In this scattering setup, we study the interplay between the Hong-Ou-Mandel (HOM) effect arising due to quantum interference and effective photon-photon interactions induced by the presence of the qubit. We calculate the two-photon scattering matrix of this system analytically and identify signatures of interference and interaction in the second-order auto- and cross-correlation functions of the scattered photons. In the dispersive regime, when qubit and cavity are far detuned from each other, we find that the JC nonlinearity can be used as an almost linear, in situ tunable beam splitter giving rise to ideal Hong-Ou-Mandel interference, generating a highly path-entangled two-photon NOON state of the scattered photons. The latter manifests itself in strongly suppressed waveguide cross-correlations and Poissonian photon number statistics in each waveguide. If the two-level system and the cavity are on resonance, the JC nonlinearity strongly modifies the ideal HOM conditions leading to a smaller degree of path entanglement and sub-Poissonian photon number statistics. In the latter regime, we find that photon blockade is associated with bunched autocorrelations in both waveguides, while a two-polariton resonance can lead to bunched as well as antibunched correlations.

  2. Bimodal Hong-Ou-Mandel Interferometry

    NASA Astrophysics Data System (ADS)

    Sundarraman, Deepika; Gilliss, Thomas; Leary, Cody

    2013-03-01

    We investigate two-photon Hong-Ou-Mandel interference in several interferometric systems, in which each of the two interfering input photons exist in arbitrary linear superpositions of the first-order Hermite-Gaussian modes HG10 and HG01 . We find that if both input photons are in balanced superpositions of the HG10 and HG01 modes, the resulting two-photon interference can be engineered to transform these diagonal Hermite-Gaussian inputs into output modes of the Laguerre Gaussian type, which are entangled with respect to both output path and transverse spatial mode. We show that such two-photon interference effects can occur even if the input photons are prepared with distinguishable transverse spatial states. This work was supported in part by the Howard Hughes Medical Institute.

  3. Atomic Hong-Ou-Mandel experiment

    NASA Astrophysics Data System (ADS)

    Lopes, R.; Imanaliev, A.; Aspect, A.; Cheneau, M.; Boiron, D.; Westbrook, C. I.

    2015-04-01

    Two-particle interference is a fundamental feature of quantum mechanics, and is even less intuitive than wave-particle duality for a single particle. In this duality, classical concepts--wave or particle--are still referred to, and interference happens in ordinary space-time. On the other hand, two-particle interference takes place in a mathematical space that has no classical counterpart. Entanglement lies at the heart of this interference, as it does in the fundamental tests of quantum mechanics involving the violation of Bell's inequalities. The Hong, Ou and Mandel experiment is a conceptually simpler situation, in which the interference between two-photon amplitudes also leads to behaviour impossible to describe using a simple classical model. Here we report the realization of the Hong, Ou and Mandel experiment using atoms instead of photons. We create a source that emits pairs of atoms, and cause one atom of each pair to enter one of the two input channels of a beam-splitter, and the other atom to enter the other input channel. When the atoms are spatially overlapped so that the two inputs are indistinguishable, the atoms always emerge together in one of the output channels. This result opens the way to testing Bell's inequalities involving mechanical observables of massive particles, such as momentum, using methods inspired by quantum optics, and to testing theories of the quantum-to-classical transition. Our work also demonstrates a new way to benchmark non-classical atom sources that may be of interest for quantum information processing and quantum simulation.

  4. Teaching quantum mechanics with the Hong-Ou-Mandel interferometer

    NASA Astrophysics Data System (ADS)

    Armendáriz, Gustavo; Cravioto-Lagos, Jorge; Velázquez, Victor; Grether, Marcela; López-Moreno, Enrique; Galvez, E. J.

    2014-07-01

    The Hong-Ou-Mandel interferometer is an optical device which allows us to prove experimentally the quantum nature of light via the quantum amplitude superposition of two indistinguishable photons. We have implemented this experiment as an advanced undergraduate laboratory experience. We were able to overcome well known difficulties with this experiment using recently reported techniques by Thomas et al. [Rev. Sci. Instr. 80, 036101 (2009), ].

  5. Eielson Air Force Base OU-1 baseline risk assessment

    SciTech Connect

    Jarvis, M.T.; Jarvis, T.T.; Van Houten, N.C.; Lewis, R.E.

    1993-09-01

    This Baseline Risk Assessment report is the second volume in a set of three volumes for operable Unit 1 (OU-1). The companion documents contain the Remedial Investigation and the Feasibility Study. Operable Unit 1 (OU-1) is one of several groups of hazardous waste sites located at Eielson Air Force Base (AFB) near Fairbanks, Alaska. The operable units at Eielson are typically characterized by petroleum, oil, lubricant/solvent contamination, and by the presence of organics floating at the water table. In 1989 and 1990, firms under contract to the Air Force conducted field studies to gather information about the extent of chemical contamination in soil, groundwater, and soil air pore space (soil gas) at the site. This report documents the results of a baseline risk assessment, which uses the 1989 and 1991 site characterization database to quantify the potential human health risk associated with past Base industrial activities in the vicinity of OU-1. Background data collected in 1992 were also used in the preparation of this report.

  6. Electron and hole Hong-Ou-Mandel interferometry

    NASA Astrophysics Data System (ADS)

    Jonckheere, T.; Rech, J.; Wahl, C.; Martin, T.

    2012-09-01

    We consider the electronic analog of the quantum optics Hong-Ou-Mandel interferometer in a realistic condensed matter device based on single electron emission in chiral edge states. For electron-electron collisions we show that the measurement of the zero-frequency current correlations at the output of a quantum point contact produces a dip giving precious information on the electronic wave packets and coherence. As a feature truly unique to Fermi statistics and condensed matter, we show that two-particle interferences between electron and hole in the Fermi sea can produce a positive peak in the current correlations, which we study for realistic experimental parameters.

  7. Hong-Ou-Mandel Interference with a Single Atom

    PubMed Central

    Ralley, K. A.; Lerner, I. V.; Yurkevich, I. V.

    2015-01-01

    The Hong-Ou-Mandel (HOM) effect is widely regarded as the quintessential quantum interference phenomenon in optics. In this work we examine how nonlinearity can smear statistical photon bunching in the HOM interferometer. We model both the nonlinearity and a balanced beam splitter with a single two-level system and calculate a finite probability of anti-bunching arising in this geometry. We thus argue that the presence of such nonlinearity would reduce the visibility in the standard HOM setup, offering some explanation for the diminution of the HOM visibility observed in many experiments. We use the same model to show that the nonlinearity affects a resonant two-photon propagation through a two-level impurity in a waveguide due to a “weak photon blockade” caused by the impossibility of double-occupancy and argue that this effect might be stronger for multi-photon propagation. PMID:26365761

  8. Hong-Ou-Mandel Interference with a Single Atom

    NASA Astrophysics Data System (ADS)

    Ralley, K. A.; Lerner, I. V.; Yurkevich, I. V.

    2015-09-01

    The Hong-Ou-Mandel (HOM) effect is widely regarded as the quintessential quantum interference phenomenon in optics. In this work we examine how nonlinearity can smear statistical photon bunching in the HOM interferometer. We model both the nonlinearity and a balanced beam splitter with a single two-level system and calculate a finite probability of anti-bunching arising in this geometry. We thus argue that the presence of such nonlinearity would reduce the visibility in the standard HOM setup, offering some explanation for the diminution of the HOM visibility observed in many experiments. We use the same model to show that the nonlinearity affects a resonant two-photon propagation through a two-level impurity in a waveguide due to a “weak photon blockade” caused by the impossibility of double-occupancy and argue that this effect might be stronger for multi-photon propagation.

  9. Portable exhausters POR-004 SKID B, POR-005 SKID C, POR-006 SKID D storage plan

    SciTech Connect

    Nelson, O.D.

    1997-09-04

    This document provides a storage plan for portable exhausters POR-004 SKID B, POR-005 SKID C, AND POR-006 SKID D. The exhausters will be stored until they are needed by the TWRS (Tank Waste Remediation Systems) Saltwell Pumping Program. The storage plan provides criteria for portable exhauster storage, periodic inspections during storage, and retrieval from storage.

  10. Geology and hydrocarbon potential of the Oued Mya basin, Algeria

    SciTech Connect

    Benamrane, O.; Messaoudi, M.; Messelles, H. )

    1993-09-01

    The Oued Mya hydrocarbon system is located in the Sahara basin. It is one of the best producing basins in Algeria, along with the Ghadames and Illizi basins. The stratigraphic section consists of Paleozoic and Mesozoic, and is about 5000 m thick. This intracratonic basin is limited to the north by the Toughourt saddle, and to the west and east it is flanked by regional arches, Allal-Tilghemt and Amguid-Hassi Messaoud, which culminate in the super giant Hassi Messaoud and Hassi R'mel hydrocarbon accumulations, respectively, producing oil from the Cambrian sands and gas from the Trissic sands. The primary source rock in this basin is lower Silurian shale, with an average thickness of 50 m and a total organic carbon of 6% (14% in some cases). Results of maturation modeling indicate that the lower Silurian source is in the oil window. The Ordovician shales are also source rocks, but in a second order. Clastic reservoirs are in the Trissic sequence, which is mainly fluvial deposits with complex alluvial channels, and the main target in the basin. Clastic reservoirs in the lower Devonian section have a good hydrocarbon potential east of the basin through a southwest-northwest orientation. The Late Trissic-Early Jurassic evaporites that overlie the Triassic clastic interval and extend over the entire Oued Mya basin, are considered to be a super-seal evaporite package, which consists predominantly of anhydrite and halite. For paleozoic targets, a large number of potential seals exist within the stratigraphic column. This super seal does not present oil dismigration possibilities. We can infer that a large amount of the oil generated by the Silurian source rock from the beginning of Cretaceous until now still is not discovered and significantly greater volumes could be trapped within structure closures and mixed or stratigraphic traps related to the fluvial Triassic sandstones, marine Devonian sands, and Cambrian-Ordovician reservoirs.

  11. Characterization and flocculability of a novel proteoglycan produced by Talaromyces trachyspermus OU5.

    PubMed

    Fang, Di; Shi, Cuicui

    2016-01-01

    A filamentous fungus strain OU5 was isolated from a soil sample for its ability to produce rich exopolymers (EPS), with high flocculation capability towards kaolin suspension and swine wastewater, at low-carbon source conditions. EPS from strain OU5 was extracted and characterized to determine its flocculating behavior and active constituents involved in the flocculation. Strain OU5 was identified as Talaromyces trachyspermus by 18S rDNA-ITS gene sequencing and morphological observation. The extracted EPS was a novel proteoglycan (designated as BF-OU5) composed of 84.6% (w/w) polysaccharides and 15.2% (w/w) proteins. The enzymatic digestion tests revealed that the polysaccharides in BF-OU5, composed of 67% glucose, 16.4% mannose, 8.6% xylose and 8% galactose, contributed to 99.7% of flocculating capacity and were the major active ingredients in the flocculation. By contrast, the proteins in BF-OU5 only had minor roles in the flocculation. The presence of hydroxyl, amide, carboxyl and methoxyl functional groups in BF-OU5, and the high molecular weight (1.053 × 10(5)-2.970 × 10(5) Da) as well as the structure of a spherical conformation with inner pores and channels made of cross-linked netted textures contributed to the flocculation. A dosage of 20 mg/l BF-OU5 initiated more than 92.5% of flocculating efficiency towards kaolin suspension without any added coagulants; its flocculability was stable over a wide range of pH (4.0-8.0) and temperature (20°C-100°C). Treatment of swine wastewater using BF-OU5 achieved 52.1% flocculating removal for chemical oxygen demand, 39.7% for Kjeldahl nitrogen, 18.6% for NH4(+)-N, 21.5% for total phosphorus, and 75% for turbidity. PMID:26073312

  12. Dynamique sédimentaire comparative dans les bassins stéphano-permiens des Ida Ou Zal et Ida Ou Ziki, haut Atlas Occidental, MarocDynamic sedimentology of two Upper Stephano-Lower Permian basins: Ida Ou Zal and Ida Ou Ziki, western High Atlas, Morocco

    NASA Astrophysics Data System (ADS)

    Saber, H.; El-Wartiti, M.; Broutin, J.

    2001-05-01

    The intra-mountainous Ida Ou Zal Basin developed as a graben during the Stephanian (Carboniferous) and Lower Permian. Along its borders from east to west are the remnants of basal conglomerates. Passing laterally towards the centre of the basin are fine-grained fluvial-lacustrine sediments or flood-plain deposits. The important accumulation (1800 m) of sediments, associated with climatic and tectonic changes, caused substantial subsidence in a late orogenic setting. The remnants of sporadic volcanic products (shards) found in the Ida Ou Zal and the Ida Ou Zika Basins suggest nearby simultaneous magmatic activity. A comparison between the basins of Ida Ou Zal and Ida Ou Ziki suggest that the two basins formed a single unit, called the Souss Basin, ultimately terminated between the Lower Permian and Upper Permian times by a sinistral movement of the N70-80° Agadir Ou Anzizen Fault (west branch of the Tizi N'Test Fault) at the very end of the Hercynian Orogeny in Morocco.

  13. The Hong-Ou-Mandel effect in the context of few-photon scattering.

    PubMed

    Longo, Paolo; Cole, Jared H; Busch, Kurt

    2012-05-21

    The Hong-Ou-Mandel effect is studied in the context of two-photon transport in a one-dimensional waveguide with a single scatterer. We numerically investigate the scattering problem within a time-dependent, wave-function-based framework. Depending on the realization of the scatterer and its properties, we calculate the joint probability of finding both photons on either side of the waveguide after scattering. We specifically point out how Hong-Ou-Mandel interferometry techniques could be exploited to identify effective photon-photon interactions which are mediated by the scatterer. The Hong-Ou-Mandel dip is discussed in detail for the case of a single two-level atom embedded in the waveguide, and dissipation and dephasing are taken into account by means of a quantum jump approach. PMID:22714220

  14. PHYSICAL MAPS OF 'AUTOGRAPHA CALIFORNICA' AND 'RACHIPLUSIA OU' NUCLEAR POLYHEDROSIS VIRUS RECOMBINANTS

    EPA Science Inventory

    TN-368 cells were infected simultaneously with the closely related Autographa californica (AcMNPV) and Rachiplusia ou (RoMNPV) nuclear polyhedrosis viruses. Progeny viral isolates were plaque purified, and their DNAs were analyzed with restriction endonucleases. Of 100 randomly c...

  15. FIELD SCALE EVALUATION OF TREATMENT OF TCE IN A BIOWALL AT THE OU-1 SITE

    EPA Science Inventory

    A passive reactive barrier (Biowall) was installed at the OU-1 site at Altus Air Force Base, Oklahoma to treat TCE contamination in ground water from a landfill. Depth to ground water varies from 1.8 to 2.4 meters below land surface. To intercept and treat the plume of contamin...

  16. Gas physical conditions and kinematics of the giant outflow Ou4

    NASA Astrophysics Data System (ADS)

    Corradi, Romano L. M.; Grosso, Nicolas; Acker, Agnès; Greimel, Robert; Guillout, Patrick

    2014-10-01

    Context. The recently discovered bipolar outflow Ou4 has a projected size of more than one degree in the plane of the sky. It is apparently centred on the young stellar cluster - whose most massive representative is the triple system HR 8119 - inside the H ii region Sh 2-129. The driving source, the nature, and the distance of Ou4 are not known. Aims: The basic properties of Ou4 and its environment are investigated to shed light on the origin of this remarkable outflow. Methods: Deep narrow-band imagery of the whole nebula at arcsecond resolution was obtained to study the details of its morphology. Long-slit spectroscopy of the bipolar lobe tips was secured to determine the gas ionisation mechanism, physical conditions, and line-of-sight velocities. An estimate of the proper motions at the tip of the south lobe using archival plate images was attempted. The existing multi-wavelength data for Sh 2-129 and HR 8119 were also comprehensively reviewed. Results: The observed morphology of Ou4, its emission-line spatial distribution, line flux ratios, and the kinematic modelling developed adopting a bow-shock parabolic geometry, illustrate the expansion of a shock-excited fast collimated outflow. The observed radial velocities of Ou4 and its reddening are consistent with those of Sh 2-129 and HR 8119. The improved determination of the distance to HR 8119 (composed of two B0 V and one B0.5 V stars) and Sh 2-129 is 712 pc. We identify in WISE images at 22 μm an emission bubble of 5' radius (1 pc at the distance above) emitted by hot (107 K) dust grains, located inside the central part of Ou4 and corresponding to several [O iii] emission features of Ou4. Conclusions: The apparent position of Ou4 and the properties studied in this work are consistent with the hypothesis that Ou4 is located inside the Sh 2-129 H ii region, suggesting that it was launched some 90 000 yr ago by HR 8119. The outflow total kinetic energy is estimated to be ≈4 × 1047 ergs. However, we cannot

  17. Spectral correlation measurements at the Hong-Ou-Mandel interference dip

    NASA Astrophysics Data System (ADS)

    Gerrits, T.; Marsili, F.; Verma, V. B.; Shalm, L. K.; Shaw, M.; Mirin, R. P.; Nam, S. W.

    2015-01-01

    We present an efficient tool capable of measuring the spectral correlations between photons emerging from a Hong-Ou-Mandel interferometer. We show that for our spectrally factorizable spontaneous down-conversion source, the Hong-Ou-Mandel interference visibility decreases as the photons' frequency spread is increased to a maximum of 165 nm. Unfiltered, we obtained a visibility of 92.0 %±0.2 %. The maximum visibility was 97 %±0.2 % after applying filtering. We show that the tool can be useful for the study of spectral correlations that impair high-visibility and high-fidelity multisource interference applications. The nature of this tool also allows for arbitrary post-selective spectral filtering and high-rate multiphoton spectral correlation measurements.

  18. Evolution of NADPH-cytochrome P450 oxidoreductases (POR) in Apiales - POR 1 is missing.

    PubMed

    Andersen, Trine Bundgaard; Hansen, Niels Bjørn; Laursen, Tomas; Weitzel, Corinna; Simonsen, Henrik Toft

    2016-05-01

    The NADPH-dependent cytochrome P450 oxidoreductase (POR) is the obligate electron donor to eukaryotic microsomal cytochromes P450 enzymes. The number of PORs within plant species is limited to one to four isoforms, with the most common being two PORs per plant. These enzymes provide electrons to a huge number of different cytochromes P450s (from 50 to several hundred within one plant). Within the eudicotyledons, PORs can be divided into two major clades, POR 1 and POR 2. Based on our own sequencing analysis and publicly available data, we have identified 45 PORs from the angiosperm order Apiales. These were subjected to a phylogenetic analysis along with 237 other publicly available (NCBI and oneKP) POR sequences found within the clade Asterids. Here, we show that the order Apiales only harbor members of the POR 2 clade, which are further divided into two distinct subclades. This is in contrast to most other eudicotyledon orders that have both POR 1 and POR 2. This suggests that through gene duplications and one gene deletion, Apiales only contain members of the POR 2 clade. Three POR 2 isoforms from Thapsia garganica L., Apiaceae, were all full-length in an Illumina root transcriptome dataset (available from the SRA at NCBI). All three genes were shown to be functional upon reconstitution into nanodiscs, confirming that none of the isoforms are pseudogenes. PMID:26854662

  19. Intermitência alfvênica gerada por caos na atmosfera solar e no vento solar

    NASA Astrophysics Data System (ADS)

    Rempel, E. L.; Chian, A. C.-L.; Macau, E. E. N.; Rosa, R. R.

    2003-08-01

    Dados medidos no vento solar rápido proveniente dos buracos coronais revelam que os plasmas no meio interplanetário são dominados por flutuações Alfvênicas, caracterizadas por uma alta correlação entre as variações do campo magnético e da velocidade do plasma. As flutuações exibem muitas características esperadas em turbulência magneto-hidrodinâmica totalmente desenvolvida, tais como intermitência e espectros contínuos. Contudo, os mecanismos responsáveis pela evolução de turbulência Alfvênica intermitente não são completamente compreendidos. Neste trabalho a teoria de caos é usada para explicar como sistemas Alfvênicos, modelados pela equação Schrödinger não-linear derivativa e pela equação Kuramoto-Sivashinsky, podem se tornar fortemente caóticos à medida em que parâmetros do plasma são variados. Pequenas perturbações no parâmetro de dissipação podem fazer com que o sistema mude bruscamente de um regime periódico, ou fracamente caótico, para um regime fortemente caótico. As séries temporais das flutuações do campo magnético nos regimes fortemente caóticos exibem comportamento intermitente, em que fases laminares ou fracamente caóticas são interrompidas por fortes estouros caóticos. É mostrado que o regime fortemente caótico é atingido quando as soluções periódicas ou fracamente caóticas globalmente estáveis interagem com soluções do sistema que são fortemente caóticas, mas globalmente instáveis. Estas soluções globalmente instáveis são conjuntos caóticos não-atrativos conhecidos como selas caóticas, e são responsáveis pelos fortes estouros nos regimes intermitentes. Selas caóticas têm sido detectadas experimentalmente em uma grande variedade de sistemas, sendo provável que elas desempenhem um papel importante na turbulência intermitente observada em plasmas espaciais.

  20. Portable exhauster POR-007/Skid E and POR-008/Skid F storage plan

    SciTech Connect

    Nelson, O.D.

    1998-07-25

    This document provides storage requirements for 1,000 CFM portable exhausters POR-O07/Skid E and POR-008/Skid F. These requirements are presented in three parts: preparation for storage, storage maintenance and testing, and retrieval from storage. The exhauster component identification numbers listed in this document contain the prefix POR-007 or POR-008 depending on which exhauster is being used.

  1. Nonlinear optical effects and Hong-Ou-Mandel interference in cavity quantum electrodynamics

    NASA Astrophysics Data System (ADS)

    Mirza, Imran M.; van Enk, Steven J.

    Pure quantum interference among single photons is one of the key ingredients to perform linear optics quantum computation (LOQC). The Hong-Ou-Mandel interference (HOMI) [C. K. Hong, Z. Y. Ou and L. Mandel, Phys. Rev. Lett. 59, (18), 2044-2046 (1987)] i.e. complete destructive interference between two identical and indistinguishable photons simultaneously entering input ports of a 50/50 beam splitter, is a well-known example in this context. In this talk, I'll present our theoretical study of HOMI in a coupled Jaynes-Cummings array. In particular and by applying quantum jump/trajectory formalism, I'll focus on how partial quantum interference between two photons survive both non-linearities produced by two-level emitter and spectral filtering due to optical cavities in our coupled cavity array setup [Imran M. Mirza and Steven J. van Enk, Opt. Comm. 343, 172-177 (2015)]. Along with LOQC, this work is crucial from the perspective of exploiting coupled cavity arrays to store single photons reliably (without altering their temporal and spectral traits) [Imran M. Mirza, Steven J. van Enk and Jeff Kimble, JOSA B, 10, 2640-2649, (2013)].

  2. Water quality assessment of a highly polluted Mediterranean River - Oued Fez (Morocco)

    NASA Astrophysics Data System (ADS)

    Perrin, J.-L.; Bellarbi, M.; Raïs, N.; Chahinian, N.; Moulin, P.; Ijjaali, M.

    2012-04-01

    In the South of the Mediterranean basin, many rivers are characterized by an alternation of very long dry periods only cut by short flood events. Currently, the socio-economical development of these zones is limited by water scarcity and poor quality of the water resources. Indeed human activities, generally concentrated in overpopulated cities, generate large quantity of domestic and industrial effluents which are directly rejected in the environment without any treatment. In Morocco, the well known city of Fez illustrates perfectly this situation, observed in most developing countries. The oued Fez receives continuously the non-treated domestic and industrial effluents (90.000 m3/day) of the city and pollutes all the downstream water bodies. Indeed, it is a tributary of the Sebou River, a major body of great economical importance used for irrigation and freshwater supply. This study aims at characterising and quantifying the pollutant concentrations and fluxes in various points of oued Fez's hydrological network and assessing its impact on the Sebou River; this river's preservation being considered a national priority in Morocco. A coupled water quality-water quantity monitoring scheme has been implemented on oued Fez since 2008. In addition to basic hydrological data, water quality samples are collected at regular intervals at 8 locations where discharge is simultaneously measured using an Acoustic Doppler Current Profiler (ADCP). Water samples are analysed for different forms of nitrogen (nitrates, nitrites, ammonium and total nitrogen), phosphorus (soluble reactive phosphorus and total phosphorus) but also total chromium which is used in the leather tanning processes, one of the most important industrial production of the city of Fez, using a photospectrometer (Hach Lange DR 2800 VIS-photometer (Germany). The results of 17 sampling campaigns, carried out over 3 hydrological years, indicate that the rural areas contribute mostly to baseflow during the wet

  3. Consequences of POR mutations and polymorphisms.

    PubMed

    Miller, Walter L; Agrawal, Vishal; Sandee, Duanpen; Tee, Meng Kian; Huang, Ningwu; Choi, Ji Ha; Morrissey, Kari; Giacomini, Kathleen M

    2011-04-10

    P450 oxidoreductase (POR) transports electrons from NADPH to all microsomal cytochrome P450 enzymes, including steroidogenic P450c17, P450c21 and P450aro. Severe POR mutations A287P (in Europeans) and R457H (in Japanese) cause the Antley-Bixler skeletal malformation syndrome (ABS) plus impaired steroidogenesis (causing genital anomalies), but the basis of ABS is unclear. We have characterized the activities of ∼40 POR variants, showing that assays based on P450c17 activities, but not cytochrome c assays, correlate with the clinical phenotype. The human POR gene is highly polymorphic: the A503V sequence variant, which decreases P450c17 activities to ∼60%, is found on ∼28% of human alleles. A promoter polymorphism (∼8% of Asians and ∼13% of Caucasians) at -152 reduces transcriptional activity by half. Screening of 35 POR variants showed that most mutants lacking activity with P450c17 or cytochrome c also lacked activity to support CYP1A2 and CYP2C19 metabolism of EOMCC (a fluorogenic non-drug substrate), although there were some remarkable differences: Q153R causes ABS and has ∼30% of wild-type activity with P450c17 but had 144% of WT activity with CYP1A2 and 284% with CYP2C19. The effects of POR variants on CYP3A4, which metabolizes nearly 50% of clinically used drugs, was examined with multiple, clinically relevant drug substrates, showing that A287P and R457H dramatically reduce drug metabolism, and that A503V variably impairs drug metabolism. The degree of activity can vary with the drug substrate assayed, as the drugs can influence the conformation of the P450. POR is probably an important contributor to genetic variation in both steroidogenesis and drug metabolism. PMID:21070833

  4. Consequences of POR mutations and polymorphisms

    PubMed Central

    Miller, Walter L.; Agrawal, Vishal; Sandee, Duanpen; Tee, Meng Kian; Huang, Ningwu; Choi, Ji Ha; Morrissey, Kari; Giacomini, Kathleen M.

    2015-01-01

    P450 oxidoreductase (POR) transports electrons from NADPH to all microsomal cytochrome P450 enzymes, including steroidogenic P450c17, P450c21 and P450aro. Severe POR mutations A287P (in Europeans) and R457H (in Japanese) cause the Antley-Bixler skeletal malformation syndrome (ABS) plus impaired steroidogenesis (causing genital anomalies), but the basis of ABS is unclear. We have characterized the activities of ~40 POR variants, showing that assays based on P450c17 activities, but not cytochrome c assays, correlate with the clinical phenotype. The human POR gene is highly polymorphic: the A503V sequence variant, which decreases P450c17 activities to ~60%, is found on ~28% of human alleles. A promoter polymorphism (~8% of Asians and ~13% of Caucasians) at −152 reduces transcriptional activity by half. Screening of 35 POR variants showed that most mutants lacking activity with P450c17 or cytochrome c also lacked activity to support CYP1A2 and CYP2C19 metabolism of EOMCC (a fluorogenic non-drug substrate), although there were some remarkable differences: Q153R causes ABS and has ~30% of wild-type activity with P450c17 but had 144% of WT activity with CYP1A2 and 284% with CYP2C19. The effects of POR variants on CYP3A4, which metabolizes nearly 50% of clinically used drugs, was examined with multiple, clinically-relevant drug substrates, showing that A287P and R457H dramatically reduce drug metabolism, and that A503V variably impairs drug metabolism. The degree of activity can vary with the drug substrate assayed, as the drugs can influence the conformation of the P450. POR is probably an important contributor to genetic variation in both steroidogenesis and drug metabolism. PMID:21070833

  5. Measurement of photon indistinguishability to a quantifiable uncertainty using a Hong-Ou-Mandel interferometer

    SciTech Connect

    Thomas, Peter J.; Cheung, Jessica Y.; Chunnilall, Christopher J.; Dunn, Malcolm H.

    2010-04-10

    We present a method for using the Hong-Ou-Mandel (HOM) interference technique to quantify photon indistinguishability within an associated uncertainty. The method allows the relative importance of various experimental factors affecting the HOM visibility to be identified, and enables the actual indistinguishability, with an associated uncertainty, to be estimated from experimentally measured quantities. A measurement equation has been derived that accounts for the non-ideal performance of the interferometer. The origin of each term of the equation is explained, along with procedures for their experimental evaluation and uncertainty estimation. These uncertainties are combined to give an overall uncertainty for the derived photon indistinguishability. The analysis was applied to measurements from an interferometer sourced with photon pairs from a parametric downconversion process. The measured photon indistinguishably was found to be 0.954+/-0.036 by using the prescribed method.

  6. Interactions and Charge Fractionalization in an Electronic Hong-Ou-Mandel Interferometer

    NASA Astrophysics Data System (ADS)

    Wahl, Claire; Rech, Jérôme; Jonckheere, Thibaut; Martin, Thierry

    2014-01-01

    We consider an electronic analog of the Hong-Ou-Mandel (HOM) interferometer, where two single electrons travel along opposite chiral edge states and collide at a quantum point contact. Studying the current noise, we show that because of interactions between copropagating edge states, the degree of indistinguishability between the two electron wave packets is dramatically reduced, leading to reduced contrast for the HOM signal. This decoherence phenomenon strongly depends on the energy resolution of the packets. Insofar as interactions cause charge fractionalization, we show that charge and neutral modes interfere with each other, leading to satellite dips or peaks in the current noise. Our calculations explain recent experimental results [E. Bocquillon, et al., Science 339, 1054 (2013)] where an electronic HOM signal with reduced contrast was observed.

  7. Multiparticle Correlations in Mesoscopic Scattering: Boson Sampling, Birthday Paradox, and Hong-Ou-Mandel Profiles

    NASA Astrophysics Data System (ADS)

    Urbina, Juan-Diego; Kuipers, Jack; Matsumoto, Sho; Hummel, Quirin; Richter, Klaus

    2016-03-01

    The interplay between single-particle interference and quantum indistinguishability leads to signature correlations in many-body scattering. We uncover these with a semiclassical calculation of the transmission probabilities through mesoscopic cavities for systems of noninteracting particles. For chaotic cavities we provide the universal form of the first two moments of the transmission probabilities over ensembles of random unitary matrices, including weak localization and dephasing effects. If the incoming many-body state consists of two macroscopically occupied wave packets, their time delay drives a quantum-classical transition along a boundary determined by the bosonic birthday paradox. Mesoscopic chaotic scattering of Bose-Einstein condensates is, then, a realistic candidate to build a boson sampler and to observe the macroscopic Hong-Ou-Mandel effect.

  8. Interactions between the hydrology and hydrochemistry of an intermittent southern Mediterranean River- Oued Fez (Morocco)

    NASA Astrophysics Data System (ADS)

    Perrin, J.-L.; Bellarbi, M.; Chahinian, N.; Raïs, N.; Moulin, P.; Ijjaali, M.

    2012-04-01

    Mediterranean catchments are often characterized by highly variable rainfall inputs and intermittent flows. In comparison to the existing knowledge on their hydrological behaviour, the interactions between flow conditions and pollution levels remain less documented. This study aims at filling that gap through a case study on Oued Fez (Morocco). Oued Fez is an intermittent river located in central-eastern Morocco. It has a 615 km2 catchment 10% of which corresponds to the city of Fez, the 3rd biggest in the kingdom (1.2 M inhabitants). Oued Fes is a tributary of the Sebou River, a major body of great economical importance used for irrigation and freshwater supply. A coupled water quality-water quantity monitoring scheme has been implemented on Oued Fez since 2008. In addition to basic hydrological data, water quality samples are collected at regular intervals at 8 locations where discharge is simultaneously measured using an Acoustic Doppler Current Profiler (ADCP). Water samples are analysed for different forms of nitrogen (nitrates, nitrites, ammonium and total nitrogen) and phosphorus (soluble reactive phosphorus and total phosphorus) using a photospectrometer (Hach Lange DR 2800 VIS-photometer (Germany). The results of the study indicate that, despite variations in annual rainfall, the catchment's hydrological response is controlled by the urban impervious zones during floods. The rural areas contribute mostly to baseflow during the wet period while non-treated anthropogenic inputs constitute most of the flow during the dry period. This in turn affects the water quality results. Indeed: - during low flow conditions the pollution levels are very high and total nitrogen and total phosphorus concentrations reach 45 mg/l N and 6.5 mg/l P respectively at the most polluted sites. - during average and high flow conditions the pollution levels decrease due to dilution. Total nitrogen and total phosphorus concentrations reach 32 mg/l N and 3.5 mg/l P respectively with

  9. Hong-Ou-Mandel experiment for temporal investigation of single-electron fractionalization

    PubMed Central

    Freulon, V.; Marguerite, A.; Berroir, J.-M.; Plaçais, B.; Cavanna, A.; Jin, Y.; Fève, G.

    2015-01-01

    Coulomb interaction has a striking effect on electronic propagation in one-dimensional conductors. The interaction of an elementary excitation with neighbouring conductors favours the emergence of collective modes, which eventually leads to the destruction of the Landau quasiparticle. In this process, an injected electron tends to fractionalize into separated pulses carrying a fraction of the electron charge. Here we use two-particle interferences in the electronic analogue of the Hong-Ou-Mandel experiment in a quantum Hall conductor at filling factor 2 to probe the fate of a single electron emitted in the outer edge channel and interacting with the inner one. By studying both channels, we analyse the propagation of the single electron and the generation of interaction-induced collective excitations in the inner channel. These complementary pieces of information reveal the fractionalization process in the time domain and establish its relevance for the destruction of the quasiparticle, which degrades into the collective modes. PMID:25896625

  10. Hong-Ou-Mandel atom interferometry in tunnel-coupled optical tweezers

    NASA Astrophysics Data System (ADS)

    Lester, Brian; Kaufman, Adam; Reynolds, Collin; Wall, Michael; Foss-Feig, Michael; Hazzard, Kaden; Rey, Ana Maria; Regal, Cindy

    2014-05-01

    We present recent work in which we demonstrate near-complete control over all the internal and external degrees of freedom of laser-cooled 87Rb atoms trapped in sub-micron optical tweezers. Utilizing this control for two atoms in two optical tweezers, we implement a massive-particle analog of the Hong-Ou-Mandel interferometer where atom tunneling plays the role of the photon beamsplitter. The interferometer is used to probe the effect of atomic indistinguishability on the two-atom dynamics for a variety of initial conditions. These experiments demonstrate the viability of the optical tweezer platform for bottom-up generation of low-entropy quantum systems and pave the way toward the direct observation of quantum dynamics in more complex finite-sized systems.

  11. Laser cooling atoms to indistinguishability: Atomic Hong-Ou-Mandel interference and entanglement through spin exchange

    NASA Astrophysics Data System (ADS)

    Kaufman, Adam

    2016-05-01

    Motional control of neutral atoms has a rich history and increasingly interest has turned to single-atom control. In my thesis work, we created a platform to individually prepare single bosonic atoms in highly pure quantum states, by developing methods to laser cool single atoms to the vibrational ground state of optical tweezer traps. Applying this toolset, we observe the atomic Hong-Ou-Mandel effect when we arrange for atom tunneling to play the role of a balanced beam splitter between two optical tweezers. In another experiment, we utilize spin exchange to create entanglement, which we then verify after spatially separating the atoms to observe their non-local correlations. Merging these results with our recent demonstration of deterministic loading of atomic arrays, our results establish the concept of quantum gas assembly, which could be applied to a variety of systems ranging from the production of single dipolar molecules to the assembly of low-entropy arrays of atoms.

  12. Hong-Ou-Mandel interference of two phonons in trapped ions

    NASA Astrophysics Data System (ADS)

    Toyoda, Kenji; Hiji, Ryoto; Noguchi, Atsushi; Urabe, Shinji

    2015-11-01

    The quantum statistics of bosons and fermions manifest themselves in the manner in which two indistinguishable particles interfere quantum mechanically. When two photons, which are bosonic particles, enter a beam-splitter with one photon in each input port, they bunch together at either of the two output ports. The corresponding disappearance of the coincidence count is the Hong-Ou-Mandel effect. Here we show the phonon counterpart of this effect in a system of trapped-ion phonons, which are collective excitations derived by quantizing vibrational motions that obey Bose-Einstein statistics. We realize a beam-splitter transformation of the phonons by employing the mutual Coulomb repulsion between ions, and perform a two-phonon quantum interference experiment using that transformation. We observe an almost perfect disappearance of the phonon coincidence between two ion sites, confirming that phonons can be considered indistinguishable bosonic particles. The two-particle interference demonstrated here is purely a quantum effect, without a classical counterpart, hence it should be possible to demonstrate the existence of entanglement on this basis. We attempt to generate an entangled state of phonons at the centre of the Hong-Ou-Mandel dip in the coincidence temporal profile, under the assumption that the entangled phonon state is successfully generated if the fidelity of the analysis pulses is taken into account adequately. Two-phonon interference, as demonstrated here, proves the bosonic nature of phonons in a trapped-ion system. It opens the way to establishing phonon modes as carriers of quantum information in their own right, and could have implications for the quantum simulation of bosonic particles and analogue quantum computation via boson sampling.

  13. The different origins of magnetic fields and activity in the Hertzsprung gap stars, OU Andromedae and 31 Comae

    NASA Astrophysics Data System (ADS)

    Borisova, A.; Aurière, M.; Petit, P.; Konstantinova-Antova, R.; Charbonnel, C.; Drake, N. A.

    2016-06-01

    Context. When crossing the Hertzsprung gap, intermediate-mass stars develop a convective envelope. Fast rotators on the main sequence, or Ap star descendants, are expected to become magnetic active subgiants during this evolutionary phase. Aims: We compare the surface magnetic fields and activity indicators of two active, fast rotating red giants with similar masses and spectral class but different rotation rates - OU And (Prot = 24.2 d) and 31 Com (Prot = 6.8 d) - to address the question of the origin of their magnetism and high activity. Methods: Observations were carried out with the Narval spectropolarimeter in 2008 and 2013. We used the least-squares deconvolution (LSD) technique to extract Stokes V and I profiles with high signal-to-noise ratio to detect Zeeman signatures of the magnetic field of the stars. We then provide Zeeman-Doppler imaging (ZDI), activity indicators monitoring, and a precise estimation of stellar parameters. We use state-of-the-art stellar evolutionary models, including rotation, to infer the evolutionary status of our giants, as well as their initial rotation velocity on the main sequence, and we interpret our observational results in the light of the theoretical Rossby numbers. Results: The detected magnetic field of OU Andromedae (OU And) is a strong one. Its longitudinal component Bl reaches 40 G and presents an about sinusoidal variation with reversal of the polarity. The magnetic topology of OU And is dominated by large-scale elements and is mainly poloidal with an important dipole component, as well as a significant toroidal component. The detected magnetic field of 31 Comae (31 Com) is weaker, with a magnetic map showing a more complex field geometry, and poloidal and toroidal components of equal contributions. The evolutionary models show that the progenitors of OU And and 31 Com must have been rotating at velocities that correspond to 30 and 53%, respectively, of their critical rotation velocity on the zero age main sequence

  14. Desigualdades por cáncer

    Cancer.gov

    Información básica de las desigualdades en salud por cáncer en EE. UU., factores que contribuyen a la carga desproporcionada del cáncer en algunos grupos y ejemplos de desigualdades en incidencia y mortalidad entre ciertos grupos de la población.

  15. L’identification et traitement du trouble panique avec ou sans agoraphobie

    PubMed Central

    Foldes-Busque, Guillaume; Marchand, André; Landry, Pierre

    2007-01-01

    RÉSUMÉ OBJECTIF Renseigner les médecins de première ligne au sujet de l’identification précoce, du diagnostic et du traitement du trouble panique avec ou sans agoraphobie (TP/A). QUALITÉ DES DONNÉES Les données et recommandations présentées proviennent d’une recension des écrits scientifiques réalisée via les banques de données PsycLIT, PsyINFO et MEDLINE (1985 à 2006) en utilisant les descripteurs panic disorder, psychotherapy, psychosocial treatment, treatment et pharmacotherapy. Les recommandations formulées par les auteurs s’appuient sur des données probantes provenant d’études d’excellente qualité. Les informations concernant le diagnostic et l’évaluation du TP/A proviennent d’études épidémiologiques récentes, de consensus et d’opinions d’experts. PRINCIPAL MESSAGE Le TP/A est un trouble psychiatrique souvent rencontré en médecine de première ligne, mais il est fréquemment sous-diagnostiqué et sous-traité. L’identification précoce de ce trouble demande une attention particulière aux symptômes médicalement inexpliqués et, le cas échéant, le médecin doit utiliser des questions spécifiques permettant d’identifier d’éventuelles attaques de panique et de cerner leur signification pour le patient. Le traitement de premier choix pour ce trouble est une psychothérapie d’orientation cognitivo-comportementale administrée par un psychologue ou un psychiatre spécialisé. Si de telles ressources ne sont pas disponibles, le médecin peut opter pour un traitement psychopharmacologique. CONCLUSION Les médecins de famille peuvent jouer un rôle central dans l’identification et le traitement des patients souffrant d’un TP/A. PMID:17934032

  16. Landslide susceptibility modelling using Fuzzy Logic in the oued Larbaa basin (Oriental Rif, Morocco)

    NASA Astrophysics Data System (ADS)

    Zezere, J. L.; Sadiki, A.; Faleh, A.; Elkoulali, E.; Garcia, R. A. C.; Oliveira, S. C.

    2009-04-01

    Together with flash floods and soil erosion, landslides are relevant natural hazards that affect marly slopes in the oued Larbaa basin, located in the Oriental Rif, Morocco. Landslides have been generated important economic, social and ecological effects, by the destruction of farming lands, and by the collapse and interruption of roads and other human infrastructures (e.g., houses). The reduction of socio-economic losses due to landslide activity needs to be accomplished through the implementation of a comprehensive mitigation landslide risk program. The first task of this program is the definition of landslide susceptible areas based on the study of relationships between spatial distribution of past landslides and the cartographic set of landslide predisposing factors. Therefore, the major aim of this work is to create a landslide susceptibility map for the study area. The oued Larbaa basin, located northwards the Taza city, has an area of 245 km2 and the elevation ranges between 450 m and 1300 m. Morphology is characterized by rounded hills cutting marly formations essentially of Cretaceous age. Land use is dominated by cereal cultures and a few sparse tree plantations. Natural vegetation shows a very high level of degradation and usually appears as shrub tufts. The inventory of instability events has been made for the study area and it includes both rainfall-triggered rotational and shallow translational slides. These landslides were included into a GIS database that comprises also the following landslide predisposing factors: slope angle, aspect and curvature, inverse wetness index, lithology and land use. The susceptibility assessment was carried out for each type of landslide (rotational slides and shallow translational slides) under the assumption that future landslides will occur under the same environmental patterns that generated landslides in the past. The modelling of landslide susceptibility was made using the Fuzzy Logic method (Fuzzy Algebraic

  17. Matter-wave quantum interference in the Hong-Ou-Mandel setup

    NASA Astrophysics Data System (ADS)

    Lewis-Swan, Robert; Kheruntsyan, Karen

    2014-05-01

    We propose an experiment to realize a matter-wave analog of the optical Hong-Ou-Mandel (HOM) effect. This is achieved by utilizing a pair of colliding Bose-Einstein condensates of ultracold atoms to generate a scattering halo of pair-correlated atoms via spontaneous four-wave mixing, analogous to optical parametric down-conversion used in the optical experiment to generate pairs of indistinguishable photons. Coupling the pair-correlated atoms by a π and π / 2 Bragg pulse realises the atom-optics analogs of mirror and beam-splitter elements of the optical HOM interferometer. We use a stochastic (positive- P representation) Bogoliubov approach to simulate the full dynamics of the experiment and by proposing a measurement protocol appropriate for the multimode nature of the scattering halo we predict a HOM-dip visibility of ~ 69 %, indicating strong quantum correlations between the scattered atoms and paves the way for a possible demonstration of a Bell inequality violation with matter-waves in a related Rarity-Tapster setup.

  18. Hong-Ou-Mandel interference with two independent weak coherent states

    NASA Astrophysics Data System (ADS)

    Hua, Chen; Xue-Bi, An; Juan, Wu; Zhen-Qiang, Yin; Shuang, Wang; Wei, Chen; Zhen-Fu, Han

    2016-02-01

    Recently, the Hong-Ou-Mandel (HOM) interference between two independent weak coherent pulses (WCPs) has been paid much attention due to the measurement-device-independent (MDI) quantum key distribution (QKD). Using classical wave theory, articles reported before show that the visibility of this kind of HOM-type interference is ≤ 50%. In this work, we analyze this kind of interference using quantum optics, which reveals more details compared to the wave theory. Analyses confirm the maximum visibility of 50%. And we conclude that the maximum visibility of 50% comes from the two single-photon states in WCPs, without considering the noise. In the experiment, we successfully approach the visibility of 50% by using WCPs splitting from the single pico-second laser source and phase scanning. Since this kind of HOM interference is immune to slow phase fluctuations, both the realized and proposed experiment designs can provide stable ways of high-resolution optical distance detection. Project supported by the National Basic Research Program of China (Grants Nos. 2011CBA00200 and 2011CB921200), the National Natural Science Foundation of China (Grant Nos. 61201239, 61205118, 11304397, and 61475148) and the “Strategic Priority Research Program (B)” of the Chinese Academy of Sciences (Grant No. XDB01030100 and XDB01030300).

  19. Integrated quantum photonic sensor based on Hong-Ou-Mandel interference.

    PubMed

    Basiri-Esfahani, Sahar; Myers, Casey R; Armin, Ardalan; Combes, Joshua; Milburn, Gerard J

    2015-06-15

    Photonic-crystal-based integrated optical systems have been used for a broad range of sensing applications with great success. This has been motivated by several advantages such as high sensitivity, miniaturization, remote sensing, selectivity and stability. Many photonic crystal sensors have been proposed with various fabrication designs that result in improved optical properties. In parallel, integrated optical systems are being pursued as a platform for photonic quantum information processing using linear optics and Fock states. Here we propose a novel integrated Fock state optical sensor architecture that can be used for force, refractive index and possibly local temperature detection. In this scheme, two coupled cavities behave as an "effective beam splitter". The sensor works based on fourth order interference (the Hong-Ou-Mandel effect) and requires a sequence of single photon pulses and consequently has low pulse power. Changes in the parameter to be measured induce variations in the effective beam splitter reflectivity and result in changes to the visibility of interference. We demonstrate this generic scheme in coupled L3 photonic crystal cavities as an example and find that this system, which only relies on photon coincidence detection and does not need any spectral resolution, can estimate forces as small as 10(-7) Newtons and can measure one part per million change in refractive index using a very low input power of 10(-10)W. Thus linear optical quantum photonic architectures can achieve comparable sensor performance to semiclassical devices. PMID:26193575

  20. Prise en Charge du Syndrome de Lyell ou Necrolyse Epidermique Toxique

    PubMed Central

    Siah, S.; Baite, A.; Bakkali, H.; Atmani, M.; Ababou, K.; Ihrai, H.

    2009-01-01

    Summary Le syndrome de Lyell ou nécrolyse épidermique toxique (NET) est une pathologie très grave des dermatoses bulleuses d'étiologie médicamenteuse. Il se caractérise par une nécrose aiguë de l'épiderme sur toute la hauteur du corps muqueux. L'aspect clinique de la NET est celui d'une brûlure étendue du deuxième degré profond. A ce tableau s'associent constamment des lésions muqueuses et une atteinte multiviscérale qui aggrave le pronostic. Nous rapportons deux cas de NET qui illustrent l'importance d'une prise en charge précoce et multidisciplinaire de ces patients atteints au sein d'un service de réanimation des brûlés, dont les fondements reposent sur l'asepsie rigoureuse, l'apport hydroélectrolytique et nutritionnel, la prévention de l'infection et son traitement par une antibiothérapie adaptée, et un nursing et des soins locaux. L'efficacité supposée des immunoglobulines intraveineuses ne repose que sur des cas isolés et il n'y a pas encore d'études randomisées. PMID:21991170

  1. Hong-Ou-Mandel Interference with Atomic Many-Body States

    NASA Astrophysics Data System (ADS)

    Islam, Rajibul; Lukin, Alexander; Ma, Ruichao; Preiss, Philipp; Rispoli, Matthew; Tai, M. Eric; Greiner, Markus

    2015-05-01

    Hong-Ou-Mandel (HOM) interference experiments are a powerful probe for the indistinguishability and underlying quantum statistics of particles. In the classic HOM experiment, a pair of identical photons incident on different input ports of a beamsplitter exits via the same output port. Using the precise control and readout afforded by our quantum gas microscope, we present an implementation of this classic experiment using massive bosons in a doublewell optical potential. Identical states are prepared on each site of the doublewell and by lowering the tunnel coupling between the sites for specific times, we drive a beam splitter operation between the sites. For single-atom Fock input states, we have realized a high fidelity beamsplitter operation and observed an HOM interference contrast of >90%. By generalizing to more complex initial states on the input ports, we have been able to establish HOM experiment protocols as a robust approach towards studying the indistinguishability of many-body states as well as probe interaction-induced effects. These techniques open a path towards the measurement of purity in a quantum system and entanglement entropy in many-body states.

  2. Electronic Hong-Ou-Mandel interferometry in two-dimensional topological insulators

    NASA Astrophysics Data System (ADS)

    Ferraro, D.; Wahl, C.; Rech, J.; Jonckheere, T.; Martin, T.

    2014-02-01

    The edge states of a two-dimensional topological insulator are characterized by their helicity, a very remarkable property which is related to the time-reversal symmetry and the topology of the underlying system. We theoretically investigate a Hong-Ou-Mandel-type setup as a tool to probe it. Collisions of two electrons with the same spin show a Pauli dip, analogous to the one obtained in the integer quantum Hall case. Moreover, the collisions between electrons of opposite spin also lead to a dip, known as Z2 dip, which is a direct consequence of the constraints imposed by time-reversal symmetry. In contrast to the integer quantum Hall case, the visibility of these dips is reduced by the presence of the additional edge channels, and crucially depends on the properties of the quantum point contact. As a unique feature of this system, we show the possibility of three-electron interference, which leads to a total suppression of the noise independently of the point contact configuration. This is assured by the peculiar interplay between Fermi statistics and topology. This work intends to extend the domain of applicability of electron quantum optics.

  3. Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System

    PubMed Central

    Gorasia, Dhana G.; Veith, Paul D.; Hanssen, Eric G.; Glew, Michelle D.; Sato, Keiko; Yukitake, Hideharu; Nakayama, Koji; Reynolds, Eric C.

    2016-01-01

    The type IX secretion system (T9SS) has been recently discovered and is specific to Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilizes the T9SS to transport many proteins including the gingipain virulence factors across the outer membrane and attach them to the cell surface via a sortase-like mechanism. At least 11 proteins have been identified as components of the T9SS including PorK, PorL, PorM, PorN and PorP, however the precise roles of most of these proteins have not been elucidated and the structural organization of these components is unknown. In this study, we purified PorK and PorN complexes from P. gingivalis and using electron microscopy we have shown that PorN and the PorK lipoprotein interact to form a 50 nm diameter ring-shaped structure containing approximately 32–36 subunits of each protein. The formation of these rings was dependent on both PorK and PorN, but was independent of PorL, PorM and PorP. PorL and PorM were found to form a separate stable complex. PorK and PorN were protected from proteinase K cleavage when present in undisrupted cells, but were rapidly degraded when the cells were lysed, which together with bioinformatic analyses suggests that these proteins are exposed in the periplasm and anchored to the outer membrane via the PorK lipid. Chemical cross-linking and mass spectrometry analyses confirmed the interaction between PorK and PorN and further revealed that they interact with the PG0189 outer membrane protein. Furthermore, we established that PorN was required for the stable expression of PorK, PorL and PorM. Collectively, these results suggest that the ring-shaped PorK/N complex may form part of the secretion channel of the T9SS. This is the first report showing the structural organization of any T9SS component. PMID:27509186

  4. Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System.

    PubMed

    Gorasia, Dhana G; Veith, Paul D; Hanssen, Eric G; Glew, Michelle D; Sato, Keiko; Yukitake, Hideharu; Nakayama, Koji; Reynolds, Eric C

    2016-08-01

    The type IX secretion system (T9SS) has been recently discovered and is specific to Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilizes the T9SS to transport many proteins including the gingipain virulence factors across the outer membrane and attach them to the cell surface via a sortase-like mechanism. At least 11 proteins have been identified as components of the T9SS including PorK, PorL, PorM, PorN and PorP, however the precise roles of most of these proteins have not been elucidated and the structural organization of these components is unknown. In this study, we purified PorK and PorN complexes from P. gingivalis and using electron microscopy we have shown that PorN and the PorK lipoprotein interact to form a 50 nm diameter ring-shaped structure containing approximately 32-36 subunits of each protein. The formation of these rings was dependent on both PorK and PorN, but was independent of PorL, PorM and PorP. PorL and PorM were found to form a separate stable complex. PorK and PorN were protected from proteinase K cleavage when present in undisrupted cells, but were rapidly degraded when the cells were lysed, which together with bioinformatic analyses suggests that these proteins are exposed in the periplasm and anchored to the outer membrane via the PorK lipid. Chemical cross-linking and mass spectrometry analyses confirmed the interaction between PorK and PorN and further revealed that they interact with the PG0189 outer membrane protein. Furthermore, we established that PorN was required for the stable expression of PorK, PorL and PorM. Collectively, these results suggest that the ring-shaped PorK/N complex may form part of the secretion channel of the T9SS. This is the first report showing the structural organization of any T9SS component. PMID:27509186

  5. Intercomparison of Groundwater Flow Monitoring Technologies at Site OU 1, Former Fort Ord, California

    SciTech Connect

    Daley, P F; Jantos, J; Pedler, W H; Mandell, W A

    2005-09-20

    This report presents an intercomparison of three groundwater flow monitoring technologies at a trichloroethylene (TCE) groundwater plume at Operational Unit 1 (OU 1) adjacent to the former Fritzsche Army Airfield at the former Fort Ord Army Base, located on Monterey Bay in northern Monterey County, California. Soil and groundwater at this site became contaminated by fuels and solvents that were burned on a portion of OU 1 called the Fire Drill Area (FDA) as part of firefighter training from 1962 and 1985. Cont Contamination is believed to be restricted to the unconfined A-aquifer, where water is reached at a depth of approximately 60 to 80 feet below the ground surface; the aquifer is from 15 to 20 feet in thickness, and is bounded below by a dense clay layer, the Salinas Valley Aquitard. Soil excavation and bioremediation were initiated at the site of fire training activities in the late 1980s. Since that time a pump-and-treat operation has been operated close to the original area of contamination, and this system has been largely successful at reducing groundwater contamination in this source area. However, a trichloroethylene (TCE) groundwater plume extends approximately 3000 ft (900 m) to the northwest away from the FDA. In this report, we have augmented flow monitoring equipment permanently installed in an earlier project (Oldenburg et al., 2002) with two additional flow monitoring devices that could be deployed in existing monitoring wells, in an effort to better understand their performance in a nearly ideal, homogeneous sand aquifer, that we expected would exhibit laminar groundwater flow owing to the site's relatively simple hydrogeology. The three flow monitoring tools were the Hydrotechnics{reg_sign} In In-Situ Permeable Flow Sensor (ISPFS), the RAS Integrated Subsurface Evaluation Hydrophysical Logging tool (HPL), and the Lawrence Livermore National Laboratory Scanning Colloidal Borescope Flow Meter (SCBFM). All three devices produce groundwater flow

  6. 200-DV-1OU Sediment and Pore Water Analysis and Report for Samples at Borehole C8096

    SciTech Connect

    Lindberg, Michael J.

    2011-10-01

    This is an analytical data report for sediment samples received at 200-DV-1 OU. On August 30, 2011 sediment samples were received from 200-DV-1 OU Borehole C8096 for geochemical studies. The analyses for this project were performed at the 331 building located in the 300 Area of the Hanford Site. The analyses were performed according to Pacific Northwest National Laboratory (PNNL) approved procedures and/or nationally recognized test procedures. The data sets include the sample identification numbers, analytical results, estimated quantification limits (EQL), and quality control data. The preparatory and analytical quality control requirements, calibration requirements, acceptance criteria, and failure actions are defined in the on-line QA plan 'Conducting Analytical Work in Support of Regulatory Programs' (CAW). This QA plan implements the Hanford Analytical Services Quality Assurance Requirements Documents (HASQARD) for PNNL.

  7. Lait humain provenant d’une banque de dons ou acheté en ligne?

    PubMed Central

    St-Onge, Maude; Chaudhry, Shahnaz; Koren, Gideon

    2015-01-01

    Résumé Question Une de mes patientes m’a demandé si elle pourrait se procurer du lait humain par Internet pour allaiter son nourrisson s’il le fallait. L’usage de lait humain provenant d’une banque de dons est-il plus sécuritaire que son achat en ligne? Réponse L’Organisation mondiale de la Santé et l’American Academy of Pediatrics recommandent d’utiliser des dons de lait humain comme choix à privilégier lorsque le lait maternel n’est pas disponible. Cependant, la Société canadienne de pédiatrie n’approuve pas le partage de lait humain non traité. Le lait humain entreposé dans les banques de lait diffère de celui qu’on peut se procurer par Internet en raison du processus rigoureux de sélection des donneuses, des fréquentes inspections de la qualité, des procédés de transport règlementés et du processus de pasteurisation conforme aux directives établies par l’Agence canadienne d’inspection des aliments. La plupart des échantillons achetés en ligne contiennent des bactéries à gram négatif ou comptent au total plus de 104 unités formant colonies de bactéries aérobiques par millilitre; ils renferment aussi en moyenne au décompte total plus de bactéries aérobiques, de bactéries à gram négatif, de coliformes et de Staphylococcus spp que les échantillons des banques de lait. La croissance de la plupart des espèces de bactéries est associée au nombre de jours en transit, ce qui porte à croire que les conditions de collecte, d’entreposage et de transport sont médiocres pour le lait acheté en ligne.

  8. [Hemorrhagic form of dengue fever observed at the Infectious Diseases Department CHU Yalgado Ouédraogo, Burkina Faso].

    PubMed

    Mamoudou, Savadogo; Boushab, Boushab Mohamed

    2016-01-01

    Dengue is a re-emerging arboviral disease in tropical countries. Haemorrhagic form may be associated with circulatory failure and produce hypovolemic shock, which is often fatal. We report a series of three cases of hemorrhagic dengue observed at the Infectious Diseases Department CHU Yalgado Ouédraogo, Ouagadougou, in order to describe its epidemiological, clinical, and evolutive characteristics. Our study included young females who had an onset age of between 35 years and 45 years, residing in the city of Ouagadougou. Despite multiple concentrated platelets transfusions and symptomatic treatment, we mourned a death. The development of antivirals and of new vaccines is a silver lining to prevent dengue lethality. PMID:27303584

  9. Water quality assessment of highly polluted rivers in a semi-arid Mediterranean zone Oued Fez and Sebou River (Morocco)

    NASA Astrophysics Data System (ADS)

    Perrin, J. L.; Raïs, N.; Chahinian, N.; Moulin, P.; Ijjaali, M.

    2014-03-01

    Oued Fez (one of the Sebou River tributaries - Morocco) allowed us to study and quantify the effect of the lack of wastewater treatment on surface water quality in semi-arid hydrological context. The analysis is based on field data collected from June 2009 to December 2011. Concentration and load patterns of nitrogen, phosphorus and chromium (used in the processing of leather) are compared in stable hydrological conditions during low flow and high flow periods in an eight-location sampling network. The Oued Fez and the Sebou River are characterised by severe pollution downstream from the city of Fez, particularly TN (mainly NH4 and Norg), TP (mainly Ppart) and TCr. The most polluted sites are those directly under the influence of domestic and industrial waste water inputs, particularly tannery effluents. Obviously, the concentrations measured at these locations are above all environmental quality standards. Pollutant loads are very heavy in the Sebou River and can contaminate the river course for kilometres. Moreover, as the water of the Sebou River is used for the irrigation of vegetables, serious problems of public health could arise. A better understanding of contaminant dynamics and self-purifying processes in these rivers will help implement actions and steps aimed at improving water quality in the Sebou River, which is the primary water supply source in Morocco and is used for agricultural and industrials purposes as well as for drinking water.

  10. Analysis of Aquifer Response, Groundwater Flow, and PlumeEvolution at Site OU 1, Former Fort Ord, California

    SciTech Connect

    Jordan, Preston D.; Oldenburg, Curtis M.; Su, Grace W.

    2005-02-24

    This report presents a continuation from Oldenburg et al. (2002) of analysis of the hydrogeology, In-Situ Permeable Flow Sensor (ISPFS) results, aquifer response, and changes in the trichloroethylene (TCE) groundwater plume at Operational Unit 1 (OU 1) adjacent to the former Fritzsche Army Airfield at the former Fort Ord Army Base, located on Monterey Bay in northern Monterey County. Fuels and solvents were burned on a portion of OU 1 called the Fire Drill Area (FDA) during airport fire suppression training between 1962 and 1985. This activity resulted in soil and groundwater contamination in the unconfined A-aquifer. In the late 1980's, soil excavation and bioremediation were successful in remediating soil contamination at the site. Shortly thereafter, a groundwater pump, treat, and recharge system commenced operation. This system has been largely successful at remediating groundwater contamination at the head of the groundwater plume. However, a trichloroethylene (TCE) groundwater plume extends approximately 3000 ft (900 m) to the northwest away from the FDA. In the analyses presented here, we augment our prior work (Oldenburg et al., 2002) with new information including treatment-system totalizer data, recent water-level and chemistry data, and data collected from new wells to discern trends in contaminant migration and groundwater flow that may be useful for ongoing remediation efforts. Some conclusions from the prior study have been modified based on these new analyses, and these are pointed out clearly in this report.

  11. Loss-tolerant state engineering for quantum-enhanced metrology via the reverse Hong-Ou-Mandel effect.

    PubMed

    Ulanov, Alexander E; Fedorov, Ilya A; Sychev, Demid; Grangier, Philippe; Lvovsky, A I

    2016-01-01

    Highly entangled quantum states, shared by remote parties, are vital for quantum communications and metrology. Particularly promising are the N00N states-entangled N-photon wavepackets delocalized between two different locations-which outperform coherent states in measurement sensitivity. However, these states are notoriously vulnerable to losses, making them difficult to both share them between remote locations and recombine in order to exploit interference effects. Here we address this challenge by utilizing the reverse Hong-Ou-Mandel effect to prepare a high-fidelity two-photon N00N state shared between two parties connected by a lossy optical medium. We measure the prepared state by two-mode homodyne tomography, thereby demonstrating that the enhanced phase sensitivity can be exploited without recombining the two parts of the N00N state. Finally, we demonstrate the application of our method to remotely prepare superpositions of coherent states, known as Schrödinger's cat states. PMID:27324115

  12. Loss-tolerant state engineering for quantum-enhanced metrology via the reverse Hong-Ou-Mandel effect

    NASA Astrophysics Data System (ADS)

    Ulanov, Alexander E.; Fedorov, Ilya A.; Sychev, Demid; Grangier, Philippe; Lvovsky, A. I.

    2016-06-01

    Highly entangled quantum states, shared by remote parties, are vital for quantum communications and metrology. Particularly promising are the N00N states--entangled N-photon wavepackets delocalized between two different locations--which outperform coherent states in measurement sensitivity. However, these states are notoriously vulnerable to losses, making them difficult to both share them between remote locations and recombine in order to exploit interference effects. Here we address this challenge by utilizing the reverse Hong-Ou-Mandel effect to prepare a high-fidelity two-photon N00N state shared between two parties connected by a lossy optical medium. We measure the prepared state by two-mode homodyne tomography, thereby demonstrating that the enhanced phase sensitivity can be exploited without recombining the two parts of the N00N state. Finally, we demonstrate the application of our method to remotely prepare superpositions of coherent states, known as Schrödinger's cat states.

  13. Contribution to the study of pollution of soil and water in Oued El Maleh area (Mohammedia, Morocco)

    NASA Astrophysics Data System (ADS)

    El hajjaji, Souad; Dahchour, Abdelmalek; Belhsaien, Kamal; Zouahri, Abdelmjid; Moussadek, Rachid; Douaik, Ahmed

    2016-04-01

    In Morocco, diffuse ground and surface water pollution in irrigated areas has caused an increase in the risk of water and soil quality deterioration. This has generated a health and environmental risks. The present study was carried out in the Oued El Maleh region located 65 Km to the south of Rabat on the Moroccan Atlantic coast. It covers a surface area of 310 km2 where agriculture constitutes the main activity of the population. This region is considered as a very important agricultural area, known nationally for its high potential for market gardening. This intensification has been accompanied by an excessive use of agrochemical inputs and poor control of irrigation and drainage. Consequently, salinization phenomena and deterioration of soil structure as well as water are about to create an alarming situation. In order to assess the state of pollution of waters and soil in the region, our study focuses on the determination of physicochemical parameters for the quality of water and soil. The obtained results from sampled wells and surface water show relatively higher values of nitrate and conductivity exceeding Moroccan national standards and revealing net degradation of water quality; therefore the water can be considered not suitable for human consumption and can induce a degradation of soil. The results of the studied soil show that the pH of these soils is weakly to moderately basic; they are usually non-saline with organic matter content moderately filled. Moreover, very high concentrations of nutrients (potassium, phosphorus and nitrogen) were recorded, highlighting poor management fertilizing vegetable crops in the region of Oued El Maleh.

  14. L’administration postnatale de corticoïdes pour traiter ou prévenir les affections pulmonaires chroniques chez les prématurés

    PubMed Central

    2002-01-01

    Le présent énoncé est conçu à l’intention des professionnels de la santé qui soignent des nouveau-nés et de jeunes nourrissons. Il vise à examiner les effets à court et à long terme de l’administration postnatale de corticoïdes systémiques et par inhalation pour prévenir ou traiter une affection pulmonaire chronique évolutive ou établie et à faire des recommandations quant à l’usage de corticoïdes chez les nourrissons à très faible poids de naissance. Le recours systématique à la dexaméthasone systémique pour prévenir ou traiter une affection pulmonaire chronique n’est pas recommandé chez les nourrissons à très faible poids de naissance.

  15. The PorX Response Regulator of the Porphyromonas gingivalis PorXY Two-Component System Does Not Directly Regulate the Type IX Secretion Genes but Binds the PorL Subunit

    PubMed Central

    Vincent, Maxence S.; Durand, Eric; Cascales, Eric

    2016-01-01

    The Type IX secretion system (T9SS) is a versatile multi-protein complex restricted to bacteria of the Bacteriodetes phylum and responsible for the secretion or cell surface exposition of diverse proteins that participate to S-layer formation, gliding motility or pathogenesis. The T9SS is poorly characterized but a number of proteins involved in the assembly of the secretion apparatus in the oral pathogen Porphyromonas gingivalis have been identified based on genome substractive analyses. Among these proteins, PorY, and PorX encode typical two-component system (TCS) sensor and CheY-like response regulator respectively. Although the porX and porY genes do not localize at the same genetic locus, it has been proposed that PorXY form a bona fide TCS. Deletion of porX in P. gingivalis causes a slight decrease of the expression of a number of other T9SS genes, including sov, porT, porP, porK, porL, porM, porN, and porY. Here, we show that PorX and the soluble cytoplasmic domain of PorY interact. Using electrophoretic mobility shift, DNA-protein co-purification and heterologous host expression assays, we demonstrate that PorX does not bind T9SS gene promoters and does not directly regulate expression of the T9SS genes. Finally, we show that PorX interacts with the cytoplasmic domain of PorL, a component of the T9SS membrane core complex and propose that the CheY-like PorX protein might be involved in the dynamics of the T9SS.

  16. Spatial assessment and source identification of trace metal pollution in stream sediments of Oued El Maadene basin, northern Tunisia.

    PubMed

    Ayari, J; Agnan, Y; Charef, A

    2016-07-01

    An extensive spatial survey was conducted on trace metal content in stream sediments from Oued El Maadene basin, northern Tunisia. Our objectives were to evaluate the level of trace metal pollution and associated ecological risk and identify the major sources of metal pollution. A total of 116 stream sediment samples were collected and analysed for total As, Cd, Cr, Cu, Ni, Pb, V, Zn, and Zr concentrations. The results showed that concentrations of Cr, Ni, V, and Zr were close to natural levels. In contrast, As, Cd, Cu, Pb, and Zn had elevated concentrations and enrichment factors compared to other contaminated regions in northern Tunisia. Ecological risk to aquatic ecosystems was highlighted in most areas. Principal component analysis showed that Cr, Ni, V, and Zr mainly derived from local soil and bedrock weathering, whilst As, Cd, Pb, and Zn originated from mining wastes. Trace metals could be dispersed downstream of tailings, possibly due to surface runoff during the short rainy season. Surprisingly, Cu, and to a lesser extent As, originated from agricultural activities, related to application of Cu-based fungicides in former vineyards and orchards. This study showed that, despite the complete cessation of mining activities several decades ago, metal pollution still impacts the local environment. This large pollution, however, did not mask other additional sources, such as local agricultural applications of fungicides. PMID:27270485

  17. Influence of rainfall space-time variability over the Ouémé basin in Benin

    NASA Astrophysics Data System (ADS)

    Gascon, T.; Vischel, T.; Lebel, T.; Quantin, G.; Pellarin, T.; Quatela, V.; Leroux, D.; Galle, S.

    2015-05-01

    In West Africa, the concomitant occurrence of extreme droughts and damaging floods points to the urgent need for linking the climate variability at various time scales (daily to decadal) to its impact in terms of water related risks. While hydrological models are key tools to do so, their use in this part of the world is strongly limited by the scarcity of rainfall data. Satellite precipitation products can be used as rainfall input to models in order to make up for this shortage of appropriate surface data. However, these satellite products have their own weaknesses, both in terms of accuracy and resolution. While the accuracy of satellite rainfall estimates has already received a fair amount of attention, little published work deals with the resolution issue. The study presented here is motivated by this lack of attention to the resolution issue. It makes use of the data produced by a very dense rainfall network covering the Ouémé catchment in Benin (14 600 km2), to study the impact of varying the space-time resolution of input rainfields on the output produced by DHSVM (Distributed Hydrology Soils and Vegetation Model), thus mimicking the resolution-induced errors associated with using satellite rainfall input for such physically-based models. The major result of this sensitivity analysis is that the model output is much more sensitive to the time resolution than to the space resolution, at least for this region and for the range of resolutions tested.

  18. Hong-Ou-Mandel interference experiment of two independent heralded single photon sources in an optical fiber with birefringence

    NASA Astrophysics Data System (ADS)

    Ma, Tianyi; Zhou, Qiang; Zhang, Wei; Huang, Yidong; Cui, Xiaowei; Lu, Mingquan; Feng, Zhenming

    2012-11-01

    Single photon sources (SPSs) play important roles in quantum communication and quantum information processing. Spontaneous four wave mixing (SFWM) in optical fibers provides a promising way to realize practical heralded single photon sources (HSPSs), since it is compatible with current techniques of optical communications. In this paper, two independent HSPSs at 1.5μm band are realized in one polarization maintaining dispersion shifted fiber (PM-DSF) utilizing its large birefringence. When pulsed pump light passes through an optical fiber, two kinds of SFWM will take place simultaneously. One is scalar processes, in which two annihilated pump photons and generated photon pair are all polarized along the same fiber polarization axis. The other is vector processes, in which two annihilated pump photons are polarized along different fiber polarization axes, either for the two photons of the generated pair. In the PM-DSF, the large birefringence generates obvious walk-off effect on the two pump polarization components, which leads to an effective suppression of the vector processes. Hence, by proper pump polarization, correlated photon pairs (CPPs) with different polarization directions can be generated independently by the two scalar processes, which can be used to realize two independent HSPSs. The indistinguishability of the heralded photons generated by the two independent sources is demonstrated by an experiment of Hong-Ou-Mandel (HOM) interference. Using a fiber coupler as the beam splitter, a visibility of HOM dip of 76% is achieved, showing their potential on quantum information.

  19. Laser-cooling atoms to indistinguishability: Atomic Hong-Ou-Mandel interference and entanglement through spin-exchange

    NASA Astrophysics Data System (ADS)

    Kaufman, Adam

    In this thesis, I describe the development of and scientific results from a new platform for creating ultracold atoms via single-atom control. We employ Raman-sideband cooling to isolated bosonic 87Rb atoms confined within sub-micron optical tweezers, yielding single particle three- dimensional ground-state fractions of 90%. We create multiple, independent, mobile optical tweezers, which simultaneously allows multi-particle studies with single-atom microscopy and highly tunable length-scales. We employ this toolset in both of the main experiments discussed in this thesis. In one experiment, we observe Hong-Ou-Mandel interference of two bosonic atoms, each of which is independently prepared in spatially separated optical tweezers. The interference we observe is a direct consequence of the purity of the single particle quantum states produced, and the indistinguishability of the atoms. In a second experiment, we introduce a spin-degree of freedom and exploit spin-exchange dynamics, driven by the quantum-statistics of the particles, to create a spin-entangled pair of spatially separated atoms.

  20. Assimilation of SMOS soil moisture products to improve streamflow simulations on the Ouémé catchment in Benin

    NASA Astrophysics Data System (ADS)

    Leroux, Delphine; Pellarin, Thierry; Vischel, Théo; Gascon, Tania; Kerr, Yann

    2015-04-01

    The Ouémé catchment is located in the central part of Benin in West Africa. Its climate, extremely dry in winter and heavy rains in summer, makes the water cycle a true challenge to model, especially for the water management in the agricultural areas. DHSVM (Distributed Hydrology Soil Vegetation Model) is a physically based and distributed hydrological model that solves the energy and water balance at each time step. This model simulates the soil moisture at each soil layer, the snow quantity, the evapotranspiration, the runoff and the streamflow. It was used with an hourly time step at a 1 km resolution. Model parameters have been calibrated using 2005 in situ streamflow measurements along with in situ precipitations. When using satellite precipitation observations, the streamflow simulations are no longer in agreement with in situ measurements. The goal of this work is to assimilate the SMOS soil moisture product into the hydrological model DHSVM using a Kalman filter for a better constraint on the water cycle model when using satellite precipitation observations. First results tend to show an improvement of the simulated streamflow using the SMOS assimilation into DHSVM. SMOS acts on the system by adding or removing some water when satellite observations are either under or overestimating the precipitations. The ESA's SMOS mission was launched in November 2009 and has been providing Soil Moisture and Ocean Salinity data for the last five years. Soil moisture products are available at a 25 km resolution with a 3-day global coverage (Level 3 data). Besides the choice of the assimilation method, the difference in spatial resolutions is also being taken care of by using an influence circle area. Highlights are mainly put on the impacts of the assimilation on the soil moisture and on the streamflow. Furthermore, DHSVM also models the water table depth and a first attempt to estimate groundwater volume for the entire watershed is presented in this study.

  1. Les considérations éthiques relatives à la désadoption d'aspects inefficaces ou nuisibles des soins de santé.

    PubMed

    Niven, Daniel J; Leigh, Jeanna Parsons; Stelfox, Henry T

    2016-09-01

    La désadoption désigne l'abandon d'une pratique médicale ou d'un service de santé inefficace ou nuisible après une période d'adoption. Tandis que les dépenses croissantes en matière de santé menacent de paralyser les sociétés qui les financent, le fait de faciliter la désadoption peut faire partie intégrante de systèmes de santé durables qui prodiguent des soins de qualité. Le présent article explore des enjeux éthiques qui se rapportent à la désadoption, y compris les principes sous-jacents de bénéficience, de non-maléficience, de justice et d'autonomie. PMID:27576859

  2. Identification of Porphyromonas gingivalis proteins secreted by the Por secretion system.

    PubMed

    Sato, Keiko; Yukitake, Hideharu; Narita, Yuka; Shoji, Mikio; Naito, Mariko; Nakayama, Koji

    2013-01-01

    The Gram-negative bacterium Porphyromonas gingivalis possesses a number of potential virulence factors for periodontopathogenicity. In particular, cysteine proteinases named gingipains are of interest given their abilities to degrade host proteins and process other virulence factors such as fimbriae. Gingipains are translocated on the cell surface or into the extracellular milieu by the Por secretion system (PorSS), which consists of a number of membrane or periplasmic proteins including PorK, PorL, PorM, PorN, PorO, PorP, PorQ, PorT, PorU, PorV (PG27, LptO), PorW and Sov. To identify proteins other than gingipains secreted by the PorSS, we compared the proteomes of P. gingivalis strains kgp rgpA rgpB (PorSS-proficient strain) and kgp rgpA rgpB porK (PorSS-deficient strain) using two-dimensional gel electrophoresis and peptide-mass fingerprinting. Sixteen spots representing 10 different proteins were present in the particle-free culture supernatant of the PorSS-proficient strain but were absent or faint in that of the PorSS-deficient strain. These identified proteins possessed the C-terminal domains (CTDs), which had been suggested to form the CTD protein family. These results indicate that the PorSS is used for secretion of a number of proteins other than gingipains and that the CTDs of the proteins are associated with the PorSS-dependent secretion. PMID:23075153

  3. Antibody Production, Anaphylactic Signs, and T-Cell Responses Induced by Oral Sensitization With Ovalbumin in BALB/c and C3H/HeOuJ Mice

    PubMed Central

    Pablos-Tanarro, Alba; López-Expósito, Ivan; Lozano-Ojalvo, Daniel; López-Fandiño, Rosina

    2016-01-01

    Purpose Two mouse strains, BALB/c and C3H/HeOuJ, broadly used in the field of food allergy, were compared for the evaluation of the allergenic potential of ovalbumin (OVA). Methods Sensitization was made by administering 2 different OVA doses (1 and 5 mg), with cholera toxin as Th2-polarizing adjuvant. Antibody levels, severity of anaphylaxis, and Th1 and Th2 responses induced by the allergen were assessed. In addition, because the mice selected had functional toll-like receptor 4, the influence of contamination with lipopolysaccharide (LPS) on the immunostimulating capacity of OVA on spleen cells was also evaluated. Results Both strains exhibited similar susceptibility to OVA sensitization. The 2 protein doses generated similar OVA-specific IgE and IgG1 levels in both strains, whereas C3H/HeOuJ mice produced significantly more IgG2a. Oral challenge provoked more severe manifestations in C3H/HeOuJ mice as indicated by the drop in body temperature and the severity of the anaphylactic scores. Stimulation of splenocytes with OVA led to significantly higher levels of Th2 and Th1 cytokines in BALB/c, and these were less affected by protein contamination with LPS. Conclusions The antibody and cytokine levels induced by OVA in BALB/c mice and the observation that BALB/c spleen cell cultures were more resistant than those of C3H/HeOuJ mice to the stimulus of LPS make this strain prone to exhibit Th2-mediated food allergic reactions and very adequate for the study of the features of OVA that make it allergenic. PMID:26922934

  4. System design description for portable 1,000 CFM exhauster Skids POR-007/Skid E and POR-008/Skid F

    SciTech Connect

    Nelson, O.D.

    1998-07-25

    The primary purpose of the two 1,000 CFM Exhauster Skids, POR-007-SKID E and POR-008-SKID F, is to provide backup to the waste tank primary ventilation systems for tanks 241-C-106 and 241-AY-102, and the AY-102 annulus in the event of a failure during the sluicing of tank 241-C-106 and subsequent transfer of sluiced waste to 241-AY-102. This redundancy is required since both of the tank ventilation systems have been declared as Safety Class systems.

  5. Calcification and Silicification: Fossilization Potential of Cyanobacteria from Stromatolites of Niuafo‘ou's Caldera Lakes (Tonga) and Implications for the Early Fossil Record

    PubMed Central

    Kazmierczak, Józef; Łukomska-Kowalczyk, Maja; Kempe, Stephan

    2012-01-01

    Abstract Calcification and silicification processes of cyanobacterial mats that form stromatolites in two caldera lakes of Niuafo‘ou Island (Vai Lahi and Vai Si‘i) were evaluated, and their importance as analogues for interpreting the early fossil record are discussed. It has been shown that the potential for morphological preservation of Niuafo‘ou cyanobacteria is highly dependent on the timing and type of mineral phase involved in the fossilization process. Four main modes of mineralization of cyanobacteria organic parts have been recognized: (i) primary early postmortem calcification by aragonite nanograins that transform quickly into larger needle-like crystals and almost totally destroy the cellular structures, (ii) primary early postmortem silicification of almost intact cyanobacterial cells that leave a record of spectacularly well-preserved cellular structures, (iii) replacement by silica of primary aragonite that has already recrystallized and obliterated the cellular structures, (iv) occasional replacement of primary aragonite precipitated in the mucopolysaccharide sheaths and extracellular polymeric substances by Al-Mg-Fe silicates. These observations suggest that the extremely scarce earliest fossil record may, in part, be the result of (a) secondary replacement by silica of primary carbonate minerals (aragonite, calcite, siderite), which, due to recrystallization, had already annihilated the cellular morphology of the mineralized microbiota or (b) relatively late primary silicification of already highly degraded and no longer morphologically identifiable microbial remains. Key Words: Stromatolites—Cyanobacteria—Calcification—Silicification—Niuafo‘ou (Tonga)—Archean. Astrobiology 12, 535–548. PMID:22794297

  6. Disminuyen en los Estados Unidos las infecciones por VPH.

    Cancer.gov

    La infección por los tipos del virus del papiloma humano (VPH) en el blanco de la vacuna cuadrivalente se redujo en casi dos tercios en las adolescentes desde que se recomendó la vacunación en los Estados Unidos.

  7. Centros oncológicos designados por el NCI

    Cancer.gov

    El programa de centros oncológicos designados por el Instituto Nacional del Cáncer (NCI) reconoce a los centros de todo el país que cumplen con rigurosos criterios para participar en proyectos avanzados de primer nivel para la investigación multidisciplinaria del cáncer.

  8. Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice

    PubMed Central

    van Wyk, Michiel; Schneider, Sabine

    2015-01-01

    Purpose Recent advances in optogenetics and gene therapy have led to promising new treatment strategies for blindness caused by retinal photoreceptor loss. Preclinical studies often rely on the retinal degeneration 1 (rd1 or Pde6brd1) retinitis pigmentosa (RP) mouse model. The rd1 founder mutation is present in more than 100 actively used mouse lines. Since secondary genetic traits are well-known to modify the phenotypic progression of photoreceptor degeneration in animal models and human patients with RP, negligence of the genetic background in the rd1 mouse model is unwarranted. Moreover, the success of various potential therapies, including optogenetic gene therapy and prosthetic implants, depends on the progress of retinal degeneration, which might differ between rd1 mice. To examine the prospect of phenotypic expressivity in the rd1 mouse model, we compared the progress of retinal degeneration in two common rd1 lines, C3H/HeOu and FVB/N. Methods We followed retinal degeneration over 24 weeks in FVB/N, C3H/HeOu, and congenic Pde6b+ seeing mouse lines, using a range of experimental techniques including extracellular recordings from retinal ganglion cells, PCR quantification of cone opsin and Pde6b transcripts, in vivo flash electroretinogram (ERG), and behavioral optokinetic reflex (OKR) recordings. Results We demonstrated a substantial difference in the speed of retinal degeneration and accompanying loss of visual function between the two rd1 lines. Photoreceptor degeneration and loss of vision were faster with an earlier onset in the FVB/N mice compared to C3H/HeOu mice, whereas the performance of the Pde6b+ mice did not differ significantly in any of the tests. By postnatal week 4, the FVB/N mice expressed significantly less cone opsin and Pde6b mRNA and had neither ERG nor OKR responses. At 12 weeks of age, the retinal ganglion cells of the FVB/N mice had lost all light responses. In contrast, 4-week-old C3H/HeOu mice still had ERG and OKR responses, and we

  9. Se evitaron casi 800 000 muertes por descenso del tabaquismo

    Cancer.gov

    Programas y estrategias de control del tabaco del siglo XX fueron responsables de la prevención de más de 795 000 muertes por cáncer de pulmón en Estados Unidos de 1975 al 2000. Si todo el tabaquismo en este país hubiera cesado después de la publicación d

  10. Nature, origine et évolution des fluides dans le district minier de la caldeira d'oued bélif (nefza, Tunisie septentrionale)

    NASA Astrophysics Data System (ADS)

    Talbi, Fouad; Slim-Shimi, Najet; Tlig, Said; Zargouni, Fouad

    1999-02-01

    Fluid inclusion studies were undertaken on quartz, fluorite and calcites in the Oued Bélif caldera ore district in northern Tunisia. Two main groups of inclusions were distinguished: a fluid inclusion group, of magmatic origin, with a temperature higher than 350 °C and salinity higher than 30 wt % NaCl; and a group of mixing between magmatic and meteoric fluids with temperatures and salinities ranging from 150 to 250 °C and from 15 to 25 wt % NaCl, respectively. These two groups result from hydrothermal circulations of respectively, "porphyry copper" and epithermal systems; this is confirmed by the nature of the alteration.

  11. Neisseria meningitidis Lacking the Major Porins PorA and PorB Is Viable and Modulates Apoptosis and the Oxidative Burst of Neutrophils.

    PubMed

    Peak, Ian R; Chen, Adrienne; Jen, Freda E-C; Jennings, Courtney; Schulz, Benjamin L; Saunders, Nigel J; Khan, Arshad; Seifert, H Steven; Jennings, Michael P

    2016-08-01

    The bacterial pathogen Neisseria meningitidis expresses two major outer-membrane porins. PorA expression is subject to phase-variation (high frequency, random, on-off switching), and both PorA and PorB are antigenically variable between strains. PorA expression is variable and not correlated with meningococcal colonisation or invasive disease, whereas all naturally-occurring strains express PorB suggesting strong selection for expression. We have generated N. meningitidis strains lacking expression of both major porins, demonstrating that they are dispensable for bacterial growth in vitro. The porAB mutant strain has an exponential growth rate similar to the parental strain, as do the single porA or porB mutants, but the porAB mutant strain does not reach the same cell density in stationary phase. Proteomic analysis suggests that the double mutant strain exhibits compensatory expression changes in proteins associated with cellular redox state, energy/nutrient metabolism, and membrane stability. On solid media, there is obvious growth impairment that is rescued by addition of blood or serum from mammalian species, particularly heme. These porin mutants are not impaired in their capacity to inhibit both staurosporine-induced apoptosis and a phorbol 12-myristate 13-acetate-induced oxidative burst in human neutrophils suggesting that the porins are not the only bacterial factors that can modulate these processes in host cells. PMID:26562068

  12. Calcification and silicification: fossilization potential of cyanobacteria from stromatolites of Niuafo'ou's Caldera Lakes (Tonga) and implications for the early fossil record.

    PubMed

    Kremer, Barbara; Kazmierczak, Józef; Lukomska-Kowalczyk, Maja; Kempe, Stephan

    2012-06-01

    Calcification and silicification processes of cyanobacterial mats that form stromatolites in two caldera lakes of Niuafo'ou Island (Vai Lahi and Vai Si'i) were evaluated, and their importance as analogues for interpreting the early fossil record are discussed. It has been shown that the potential for morphological preservation of Niuafo'ou cyanobacteria is highly dependent on the timing and type of mineral phase involved in the fossilization process. Four main modes of mineralization of cyanobacteria organic parts have been recognized: (i) primary early postmortem calcification by aragonite nanograins that transform quickly into larger needle-like crystals and almost totally destroy the cellular structures, (ii) primary early postmortem silicification of almost intact cyanobacterial cells that leave a record of spectacularly well-preserved cellular structures, (iii) replacement by silica of primary aragonite that has already recrystallized and obliterated the cellular structures, (iv) occasional replacement of primary aragonite precipitated in the mucopolysaccharide sheaths and extracellular polymeric substances by Al-Mg-Fe silicates. These observations suggest that the extremely scarce earliest fossil record may, in part, be the result of (a) secondary replacement by silica of primary carbonate minerals (aragonite, calcite, siderite), which, due to recrystallization, had already annihilated the cellular morphology of the mineralized microbiota or (b) relatively late primary silicification of already highly degraded and no longer morphologically identifiable microbial remains. PMID:22794297

  13. Total petroleum systems of the Trias/Ghadames Province, Algeria, Tunisia, and Libya; the Tanezzuft-Oued Mya, Tanezzuft-Melrhir, and Tanezzuft-Ghadames

    USGS Publications Warehouse

    Klett, T.R.

    2000-01-01

    Undiscovered conventional oil and gas resources were assessed within total petroleum systems of the Trias/Ghadames Province (2054) as part of the U.S. Geological Survey World Petroleum Assessment 2000. The Trias/Ghadames Province is in eastern Algeria, southern Tunisia, and westernmost Libya. The province and its total petroleum systems generally coincide with the Triassic Basin. The province includes the Oued Mya Basin, Melrhir Basin, and Ghadames (Berkine) Basin. Although several total petroleum systems may exist within each of these basins, only three ?composite? total petroleum systems were identified. Each total petroleum system occurs in a separate basin, and each comprises a single assessment unit. The main source rocks are the Silurian Tanezzuft Formation (or lateral equivalents) and Middle to Upper Devonian mudstone. Maturation history and the major migration pathways from source to reservoir are unique to each basin. The total petroleum systems were named after the oldest major source rock and the basin in which it resides. The estimated means of the undiscovered conventional petroleum volumes in total petroleum systems of the Trias/Ghadames Province are as follows: [MMBO, million barrels of oil; BCFG, billion cubic feet of gas; MMBNGL, million barrels of natural gas liquids] Total Petroleum System MMBO BCFG MMBNGL Tanezzuft-Oued Mya 830 2,341 110 Tanezzuft-Melrhir 1,875 4,887 269 Tanezzuft-Ghadames 4,461 12,035 908

  14. Aspects of choosing appropriate concepts for modelling groundwater resources in regional integrated water resources management Examples from the Neckar (Germany) and Ouémé catchment (Benin)

    NASA Astrophysics Data System (ADS)

    Barthel, R.; Jagelke, J.; Götzinger, J.; Gaiser, T.; Printz, Andreas

    Two regional groundwater flow models (Neckar catchment, Germany, 14,000 km 2, and Southern Ouémé Basin, Benin, 11,000 km 2) were developed within the framework of the integrated management project ‘RIVERTWIN’ ( www.rivertwin.org). Both models were evaluated with respect to the question if the chosen modelling approaches (multi-layered finite difference numerical flow modelling, steady state and transient) are appropriate in view of the existing management problems in the catchments, the data availability and the hydrogeological and hydrological conditions in the basins. It is shown that neither the model in the well-investigated, data-rich basin in Western Europe with its highly developed water related infrastructure, nor the model in the hydrogeologically less well-known and less developed basin in Western Africa provide results that are fully applicable to the main regional management tasks. In the case of the Ouémé, the groundwater related problems are foremost of local character and therefore cannot be addressed by regional models in a meaningful way. Data scarcity and complex, unfavourable geological conditions (crystalline rocks, discontinuous aquifers) support the conclusion that numerical 3D groundwater flow models are currently not helpful to manage groundwater related management problems in the Ouémé basin. A better understanding of regional hydrological surface and subsurface processes is required first. Methods for a reliable estimation of groundwater recharge and subsequently groundwater availability were identified as the most urgently needed tool for meaningful groundwater management in view of climatic, demographic and land use change. In the Neckar catchment the results of the analysis are less pronounced; here regional groundwater problems could clearly benefit from a physically based 3D model since the hydrogeological system is strictly stratified with several important aquifers in the vertical sequence. As a general conclusion it can

  15. Compton imaging with the PorGamRays spectrometer

    NASA Astrophysics Data System (ADS)

    Judson, D. S.; Boston, A. J.; Coleman-Smith, P. J.; Cullen, D. M.; Hardie, A.; Harkness, L. J.; Jones, L. L.; Jones, M.; Lazarus, I.; Nolan, P. J.; Pucknell, V.; Rigby, S. V.; Seller, P.; Scraggs, D. P.; Simpson, J.; Slee, M.; Sweeney, A.; PorGamRays Collaboration

    2011-10-01

    The PorGamRays project aims to develop a portable gamma-ray detection system with both spectroscopic and imaging capabilities. The system is designed around a stack of thin Cadmium Zinc Telluride (CZT) detectors. The imaging capability utilises the Compton camera principle. Each detector is segmented into 100 pixels which are read out through custom designed Application Specific Integrated Circuits (ASICs). This device has potential applications in the security, decommissioning and medical fields. This work focuses on the near-field imaging performance of a lab-based demonstrator consisting of two pixelated CZT detectors, each of which is bonded to a NUCAM II ASIC. Measurements have been made with point 133Ba and 57Co sources located ˜35 mm from the surface of the scattering detector. Position resolution of ˜20 mm FWHM in the x and y planes is demonstrated.

  16. Acceptance test report for portable exhauster POR-007/Skid E

    SciTech Connect

    Kriskovich, J.R.

    1998-07-24

    This document describes Acceptance Testing performed on Portable Exhauster POR-007/Skid E. It includes measurements of bearing vibration levels, pressure decay testing, programmable logic controller interlocks, high vacuum, flow and pressure control functional testing. The purpose of Acceptance testing documented by this report was to demonstrate compliance of the exhausters with the performance criteria established within HNF-0490, Rev. 1 following a repair and upgrade effort at Hanford. In addition, data obtained during this testing is required for the resolution of outstanding Non-conformance Reports (NCR), and finally, to demonstrate the functionality of the associated software for the pressure control and high vacuum exhauster operating modes provided for by W-320. Additional testing not required by the ATP was also performed to assist in the disposition and close out of receiving inspection report and for application design information (system curve). Results of this testing are also captured within this document.

  17. Determination of heavy metals in suspended waste water collected from Oued El Harrach Algiers River by Energy Dispersive X-Ray Fluorescence

    NASA Astrophysics Data System (ADS)

    Ouziane, S.; Amokrane, A.; Toumert, I.

    2013-12-01

    A preliminary study of the atmospheric pollution in the centre of Algiers is one of the important fields of applications in the environmental science. Nowadays, we need to evaluate the level of the contamination which has an unfavourable effect on physicochemical properties of soils and plants and namely also on human health. In the present work, water samples collected from Oued El-Harrach Algiers River, have been filtered in 0.45 μm Millipore filters to be analysed by Energy Dispersive X-Ray Fluorescence technique using 109Cd radioisotope source. Concentrations of the toxic elements like heavy metals are determined and compared with the published ones values by Yoshida [1] and those obtained using PIXE and NAA techniques [6].

  18. Le fibromatosis colli ou torticolis congénital: son diagnostic et sa prise en charge à propos de deux cas

    PubMed Central

    Tchaou, Mazamaesso; Pegbessou, Plaodezina Essobozou; Sonhaye, Lantam; Ahouanssou, Patricia Yékpé; Amadou, Abdoulatif; Kolou, Beresa; Kama, Lidi Bessi; Garba, Nouhou Mahamadou; Koussema, Lama Kegdigoma Agoda; N'dakéna, Koffi

    2015-01-01

    Le fibromatosis colli (FC) est pseudotumeur rare du muscle sterno-cléido-mastoïdien (SCM), à l'origine d'un torticolis dit congénital chez le nouveau-né ou le nourrisson. Le mécanisme étio-pathogénique de sa survenue est sujet à controverse. Son diagnostic fait appel à l’échographie qui permet de mettre en évidence un épaississement caractéristique du muscle. Nous rapportons deux cas diagnostiqués par l’échographie avec pour un cas une notion de malposition intra-utérine et pour l'autre cas une absence totale de malposition et de traumatisme obstétrical qui pourtant est évoqué comme élément du mécanisme de survenue du FC. PMID:26834927

  19. Response of Nereis diversicolor (Polychaeta, Nereidae) populations to reduced wastewater discharge in the polluted estuary of Oued Souss, Bay of Agadir, Morocco

    NASA Astrophysics Data System (ADS)

    Ait Alla, A.; Gillet, P.; Deutsch, B.; Moukrim, A.; Bergayou, H.

    2006-12-01

    Field investigations on the population dynamics of Nereis diversicolor were carried out from January 2002 to December 2003 in the estuary of Oued Souss (southwestern Morocco) to determine the changes caused by setting up of a domestic and industrial wastewater purification plant (M'zar) before and after by the end of wastewater discharges in November 2002 on the structure of the ecosystem. Samples of N. diversicolor were collected monthly in the intertidal zone at low tide before (during 2002) and after (during 2003) the end of wastewater discharges. Separation of cohorts using the Algorithm EM method (McLachlan, G.J., Krishnan, T., 1997. The EM algorithm and extensions. Wiley Series in Probability and Statistics. Wiley, New York, 274 pp.) allowed determination of the growth rate (mm day -1) by cohort and the annual production. The data showed significant differences between populations of Nereis diversicolor before and after the end of wastewater discharges. During the wastewater discharge period (2002), the population had a mean annual density of 1992 ind m -2, a mean annual biomass of 75.52 g DW m -2 and an annual secondary production of 141.3 g DW m -2 with a P/ B ratio of 1.87. After the end of discharges (2003), density, biomass and secondary production decreased significantly. The annual averages for these parameters were 740 ind m -2, 14.16 g DW m -2 and 23.83 g DW m -2, respectively, with a P/ B ratio of 1.68. The important decrease observed in density, biomass and secondary production of Nereis diversicolor may be attributed (a) to the environmental changes observed after the end of wastewater discharges in the estuary of Oued Souss, namely the increase of salinity and the decrease of organic matter content, and (b) to the migration of this species towards other areas.

  20. Slug Test Characterization Results for Multi-Test/Depth Intervals Conducted During the Drilling of CERCLA Operable Unit OU UP-1 Wells 299-W19-48, 699-30-66, and 699-36-70B

    SciTech Connect

    Spane, Frank A.; Newcomer, Darrell R.

    2010-06-15

    This report presents test descriptions and analysis results for multiple, stress-level slug tests that were performed at selected test/depth intervals within three Operable Unit (OU) UP-1 wells: 299-W19-48 (C4300/Well K), 699-30-66 (C4298/Well R), and 699-36-70B (C4299/Well P). These wells are located within, adjacent to, and to the southeast of the Hanford Site 200-West Area. The test intervals were characterized as the individual boreholes were advanced to their final drill depths. The primary objective of the hydrologic tests was to provide information pertaining to the areal variability and vertical distribution of hydraulic conductivity with depth at these locations within the OU UP-1 area. This type of characterization information is important for predicting/simulating contaminant migration (i.e., numerical flow/transport modeling) and designing proper monitor well strategies for OU and Waste Management Area locations.

  1. Slug Test Characterization Results for Multi-Test/Depth Intervals Conducted During the Drilling of CERCLA Operable Unit OU ZP-1 Wells 299-W11-43, 299-W15-50, and 299-W18-16

    SciTech Connect

    Spane, Frank A.; Newcomer, Darrell R.

    2010-06-21

    The following report presents test descriptions and analysis results for multiple, stress level slug tests that were performed at selected test/depth intervals within three Operable Unit (OU) ZP-1 wells: 299-W11-43 (C4694/Well H), 299-W15-50 (C4302/Well E), and 299-W18-16 (C4303/Well D). These wells are located within south-central region of the Hanford Site 200-West Area (Figure 1.1). The test intervals were characterized as the individual boreholes were advanced to their final drill depths. The primary objective of the hydrologic tests was to provide information pertaining to the areal variability and vertical distribution of hydraulic conductivity with depth at these locations within the OU ZP-1 area. This type of characterization information is important for predicting/simulating contaminant migration (i.e., numerical flow/transport modeling) and designing proper monitor well strategies for OU and Waste Management Area locations.

  2. Typing and surface charges of the variable loop regions of PorB from Neisseria meningitidis.

    PubMed

    Stefanelli, Paola; Neri, Arianna; Tanabe, Mikio; Fazio, Cecilia; Massari, Paola

    2016-06-01

    PorB is a pan-Neisserial major outer membrane protein with a trimeric β-barrel structure. Each monomer presents eight periplasmic turns and eight surface exposed loop regions with sequence variability. PorB induces activation of host cell responses via a TLR2-dependent mechanism likely mediated by electrostatic interactions between TLR2 and PorB surface exposed loops. Variability in the loop amino acid sequence is known to influence cell responses to PorB in vitro, particularly for the residues in L5 and L7. In this work, the sequence of the porB gene and the electrostatic surface charges of PorB from 35 invasive meningococcal isolates belonging to the main clonal complexes identified in Italy and from five carriage genomes available on the website http://pubmlst.org/neisseria/ were examined. Analysis of the porB encoding regions from the invasive meningococci has identified four new alleles and a potential association between porB alleles, serogroup, and clonal complexes. Through computer-based modeling and analysis of the electrostatic surface charges of PorB from these strains, loop charge segregation between PorB from invasive serogroups B and C was observed. Specifically, loops 1, 4, and 7 were negatively charged and L2 and L8 were mostly neutral in serogroup B isolates, while an overall homogeneous positive surface charge was present in PorB from invasive serogroup C strains. A higher PorB sequence variability was observed among carriage genomes, and a general prevalence of negative loop surface charges. The surface charge differences in PorB from serogroups B and C invasive and carriage strains may, in part, influence the outcomes of Neisseriae interactions with host cells. © 2016 IUBMB Life, 68(6):488-495, 2016. PMID:27156582

  3. Aquisição fonológica do português brasileiro por crianças ouvintes bilíngues bimodais e surdas usuárias de implante coclear

    PubMed Central

    Cruz, Carina Rebello; Finger, Ingrid

    2014-01-01

    Resumo O presente estudo investiga a aquisição fonológica do Português Brasileiro (PB) por 24 crianças ouvintes bilíngues bimodais, com acesso irrestrito à Língua Brasileira de Sinais (Libras), e por 6 crianças surdas que utilizam implante coclear (IC), com acesso restrito ou irrestrito à Libras. Para a avaliação do sistema fonológico das crianças em PB, foi utilizada a Parte A, Prova de Nomeação, do ABFW – Teste de Linguagem Infantil (ANDRADE et al. 2004). Os resultados revelaram que as crianças ouvintes bilíngues bimodais e a criança surda usuária de IC com acesso irrestrito à Libras apresentaram processo de aquisição fonológica esperada (normal) para a sua faixa etária. Considera-se que a aquisição precoce e o acesso irrestrito à Libras podem ter sido determinantes para o desempenho dessas crianças no teste oral utilizado. PMID:25506105

  4. Acceptance test report for portable exhauster POR-008/Skid F

    SciTech Connect

    Kriskovich, J.R.

    1998-07-24

    Portable Exhauster POR-008 was procured via HNF-0490, Specification for a Portable Exhausted System for Waste Tank Ventilation. Prior to taking ownership, acceptance testing was performed at the vendors. However at the conclusion of testing a number of issues remained that required resolution before the exhausters could be used by Project W-320. The purpose of acceptance testing documented by this report was to demonstrate compliance of the exhausters with the performance criteria established within HNF-O49O, Rev. 1 following a repair and upgrade effort at Hanford. In addition, data obtained during this testing is required for the resolution of outstanding Non-conformance Reports (NCR), and finally, to demonstrate the functionality of the associated software for the pressure control and high vacuum exhauster operating modes provided for by W-320. Additional testing not required by the ATP was also performed to assist in the disposition and close out of receiving inspection report and for application design information (system curve). Results of this testing are also captured within this document.

  5. The Rough and the Smooth--Students' Experiences of O.U. Study. Open-Ended Feedback from the Student Opinion Survey. The "Pete Davey Survey." Report No. 2.

    ERIC Educational Resources Information Center

    Mason, Robin; Morgan, Alistair

    The Student Opinion Survey was sent to a random sample of 2,600 Open University (OU) students who had gained at least two credits and were studying during 1984. The response rate was 84 percent. Responses to open-ended questions on about one-third of those questionnaires were analyzed to determine the significant phenomena in students' experiences…

  6. Détention provisoire des jeunes femmes accusées d'avortement clandestin ou d'infanticide au Sénégal

    PubMed Central

    Soumah, Mohamed Maniboliot; Pemba, Liliane Flore

    2012-01-01

    Introduction L'activité sexuelle chez les jeunes les expose à un accroissement du risque de contracter des grossesses non désirées. Le recours à l'avortement clandestin avec son corollaire de complications peut entrainer le décès de la jeune femme. Avortement et infanticide sont interdits et sanctionnés par la loi sénégalaise. Comment ces jeunes femmes vivent-elles leur détention? Existe-il des alternatives à la détention pour éviter leur désocialisation? Méthodes Cette étude rétrospective portait sur la maison d'arrêt des femmes de Dakar située à Liberté 6, un quartier de Dakar. Nous avons procédé à des entretiens avec des femmes détenues à la maison d'arrêt des femmes de Dakar et suspectées d'infanticide ou d'avortement clandestin. Résultats Les femmes de notre échantillon ont une moyenne d’âge inférieure à 25 ans avec parmi elles une fille mineure de 16 ans. Nous avons trouvé 18,51% de femmes suspectées d'infanticide ou d'avortement. Dans notre étude 50% des femmes sont originaires de la périphérie et de la banlieue de Dakar et presque 44% proviennent des autres régions du pays. La durée moyenne de détention provisoire est de neuf mois. Conclusion Malgré leur qualification distincte dans le code pénal: l'infanticide est un crime et l'avortement un délit, les femmes suspectées d'avoir commis ces actes sont soumises à de longues détentions préventives. PMID:22937189

  7. VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways.

    PubMed

    Müller, Anne; Rassow, Joachim; Grimm, Jan; Machuy, Nikolaus; Meyer, Thomas F; Rudel, Thomas

    2002-04-15

    The human pathogen Neisseria gonorrhoeae induces host cell apoptosis during infection by delivering the outer membrane protein PorB to the host cell's mitochondria. PorB is a pore-forming beta-barrel protein sharing several features with the mitochondrial voltage-dependent anion channel (VDAC), which is involved in the regulation of apoptosis. Here we show that PorB of pathogenic Neisseria species produced by host cells is efficiently targeted to mitochondria. Imported PorB resides in the mitochondrial outer membrane and forms multimers with similar sizes as in the outer bacterial membrane. The mitochondria completely lose their membrane potential, a characteristic previously observed in cells infected with gonococci or treated with purified PorB. Closely related bacterial porins of non-pathogenic Neisseria mucosa or Escherichia coli remain in the cytosol. Import of PorB into mitochondria in vivo is independent of a linear signal sequence. Insertion of PorB into the mitochondrial outer membrane in vitro depends on the activity of Tom5, Tom20 and Tom40, but is independent of Tom70. Our data show that human VDAC and bacterial PorB are imported into mitochondria by a similar mechanism. PMID:11953311

  8. Fiabilité des structures mécaniques adaptatives: effet de la panne des actionneurs ou des capteurs sur la stabilité

    NASA Astrophysics Data System (ADS)

    Fall, H.; Charon, W.; Kouta, R.

    2002-12-01

    Ces dernières décennies, des activités significatives dans le monde étaient dirigées autour du contrôle actif. Le but de ces recherches était essentiellement d'améliorer les performances, la fiabilité et la sécurité des systèmes. Notamment dans le cas des structures soumises à des vibrations aléatoires. D'importants travaux ont été consacré à l'utilisation des “matériaux intelligents” comme capteurs et actionneurs. Cette article propose l'analyse de la fiabilité des systèmes mécaniques en étudiant les pannes des actionneurs ou des capteurs. L'effet de ces pannes sur la stabilité et la performance du système y est démontré. Les méthodologies de conception y sont rappelées. Des exemples numériques sont fournis à travers le contrôle d'un panneau sous chargement dynamique pour illustrer la méthode proposée.

  9. Soil Organic Carbon Pool and Its Chemical Composition in Phyllostachy pubescens Forests at Two Altitudes in Jian-ou City, China

    PubMed Central

    Ji, Haibao; Zhuang, Shunyao; Zhu, Zhaoliang; Zhong, Zheke

    2015-01-01

    Phyllostachys pubescens forests play an important role in soil organic carbon (SOC) sequestration in terrestrial ecosystems. However, the estimation and mechanism of SOC sequestration by P. pubescens forests remain unclear. In this study, the effect of P. pubescens forest distribution with elevation was investigated at two altitude sites in Jian-ou City, Southeast China. SOC storage was estimated and its chemical composition was obtained via 13C-nuclear magnetic resonance (NMR), chemical classification, and spectral analysis. Results showed that the SOC contents and stocks were significantly higher at the high-altitude site than at the low-altitude site in the entire soil profile (0–60 cm). The C contents of the three combined humus forms exhibited similar responses to the elevation change, and all of these forms were higher at the high-altitude site than at the low-altitude site regardless of soil layer. However, the proportions of the three combined humus C showed no significant differences between the two altitudes. The results of 13C-NMR showed that the SOC chemical composition did not significantly vary with elevation as well. This finding was consistent with the E465/E665 of the loosely combined humus. Overall, the results suggested that altitude should be considered during regional SOC estimation and that altitude affected the quantity rather than the quality of the SOC under the same P. pubescens vegetation. PMID:26716688

  10. Coupling of spin and orbital degrees of freedom in tunable Hong-Ou-Mandel interference involving photons in hybrid spin-orbit modes

    NASA Astrophysics Data System (ADS)

    Leary, Cody C.; Lankford, Maggie; Sundarraman, Deepika

    2015-05-01

    We investigate the connection between biphoton states involving photons in product modes of their spin and orbital degrees of freedom and those involving photons in hybrid spin-orbit modes, as mediated by Hong-Ou-Mandel interference (HOMI) in an asymmetric Mach-Zehnder interferometer. We predict that two input photons in balanced superposition states of both their spin and orbital degrees of freedom will exhibit HOMI while undergoing a simultaneous mode conversion from product spin-orbit input modes to hybrid output modes bearing orbital angular momentum. These hybrid outputs contain a spatially varying polarization structure which may be controllably rotated about the photonic beam axis by varying the relative phase between the vertical and horizontal components of each input photon's polarization. Additionally, a type of coupling of the spin and orbital degrees of freedom is exhibited in this system: the transverse spatial profile of the output photons may be continuously manipulated by tuning the polarization parameters of the input photons, in such a way that the HOMI between the photons remains stable. An interesting corollary to this work is the possibility of demonstrating in a simple experimental system that HOMI may occur between distinguishable input modes.

  11. Formes hémorragiques de Dengue observées dans le service des maladies infectieuses du CHU Yalgado Ouédraogo, Burkina Faso

    PubMed Central

    Mamoudou, Savadogo; Boushab, Boushab Mohamed

    2016-01-01

    La dengue est une arbovirose ré émergente dans les pays tropicaux. Sa forme hémorragique peut s'accompagner d'une défaillance circulatoire pouvant conduire à un choc hypovolémique, souvent fatal. Nous rapportons une série de trois cas de formes hémorragiques de dengue observées dans le service des maladies infectieuses du CHU Yalgado Ouédraogo de Ouagadougou dont l'objectif est de décrire les caractéristiques épidémiologiques cliniques et évolutives. Les cas étaient des jeunes de sexe féminin dont l’âge variait entre 27 ans et 43 ans, résidant dans la ville de Ouagadougou. Malgré de multiples transfusions de concentrées plaquettaires et un traitement symptomatique, nous déplorons un cas de décès. Le développement d'antiviraux et la mise au point de nouveaux vaccins constituent une lueur d'espoir pour prévenir la létalité due à cette maladie. PMID:27303584

  12. Improvement and Comparative Assessment of a New Hydrological Modelling Approach for the Ouémé River Basin (Bénin), West Africa

    NASA Astrophysics Data System (ADS)

    GABA, C. O. U.

    2015-12-01

    Assessing water resources is still an important issue especially in the context of climatic changes. Although numerous hydrological models exist, new approaches are still under investigation. In this context, we propose a new modelling approach based on the Physics Principle of Least Action. A first version of a Least Action based model, in its deterministic version has already given very good results on simulating the Bétérou catchment in the Ouémé basin, Benin. The paper presents new hypotheses to go further in the model development with a view of widening its application. The improved version of the model MODYPMA was applied on 22 subcatchments in Africa, in Bénin, Côte d'Ivoire, Ethiopia; in Europe, and in the USA. Its performance was compared to two well known lumped conceptual models, the GR4J and HBV models. The model could be successfully calibrated and validated; it shows a good performance for a range of scales but a limited applicability to catchments smaller than 500 km2 . The analysis revealed that the three models have similar performance and timing errors. The parameter uncertainty was analysed using the GLUE methodology. It is concluded that model uncertainty is higher during high flows and that uncertainty analysis should include the uncertainty of the discharge data. Finally, some aspects that further research must address are brought out.

  13. Reducing the basin vulnerability by land management practices under past and future climate: a case study of the Nam Ou River Basin, Lao PDR

    NASA Astrophysics Data System (ADS)

    Maharjan, M.; Babel, M. S.; Maskey, S.

    2014-08-01

    This research evaluates different land management practices for the Nam Ou River Basin in Northern Laos for reducing vulnerability of the basin due to erosion and sediment yield under existing and future climate conditions. We use climate projection data (precipitation and temperature) from three general circulation models (GCMs) for three greenhouse gas emission scenarios (GHGES), namely B1, A1B and A2 and three future periods, namely 2011-2030, 2046-2065 and 2080-2099. These large resolution GCM data are downscaled using the Long Ashton Research Station-Weather Generator (LARS-WG). The Soil and Water Assessment Tool (SWAT), which is a process based hydrological model, is used to simulate discharge and sediment yield and a threshold value of annual sediment yield is applied to identify vulnerable sub-basins. Results show that the change in the annual precipitation is expected to be between -7.60 to 2.64% in 2011-2030, -8.98 to 11.85% in 2046-2065, and -11.04 to 25.84% in 2080-2099. In the meantime, the changes in mean monthly temperature vary from 0.3 to 1.3 °C in the 2011-2030, 1.3 to 2.9 °C in the 2046-2065 and 1.9 to 4.9 °C in the 2080-2099. Five sub-basins are identified vulnerable (critical) under the current climate. Our results show that terracing is the most effective land management practice to reduce sediment yield in these sub-basins followed by strip-cropping and filter strip. Appropriate land management practices applied under future climate scenarios show significant reduction in sediment yield (i.e. up to the tolerance limit) except for some sub-basins. In these exceptional sub-basins, designing an optimum combination of management practices is essential to reduce the vulnerability of the basin.

  14. Comparative study of microflora in Rhizospheric soils of Argania spinosa and Acacia raddiana of the arid zone from Oued El Ma (Tindouf)

    NASA Astrophysics Data System (ADS)

    Tissouras, Fatiha; Habib, Semira; Missoum, Malika; Louacini, Braim Kamel

    2016-04-01

    Desert soils occupy a large area in Algeria (80Moreover, exploitation of the Saharan soil microorganisms has several interests and especially in maintaining the ecological equilibrium of ecosystems. Unfortunately, few of microbiological studies have been conducted so far about the Saharan soil Algerian, with the exception of some work done on the desert soils in the region of Beni Ounif. This work falls within the framework of Project CNEPRU F02320100009. The study focuses on an evaluation of the main germs rhizosphere soils from Argania spinosa and Acacia raddiana of the region of Oued El-ma (wilaya of Tindouf), located in southwest Algeria, followed by physicochemical analysis of some parameters (soil texture, pH, moisture content, organic matter). The results reveal that both rhizosphere soils have a sandy silt texture of alkali pH, with very low water content slightly different. Organic material of the rate varies from 0.2 to 1The type of vegetation influences positively the quantity and the dynamics of microbial population. Indeed, the two soils have an interesting microbial diversity, with densities of azotobacters, fungi, aerobic bacteria and actinomycetes are very high, followed germs ammonifiants, nitrifying and denitrifying. In the presence of Argania spinosa the microbial growth is most important (6.53 × 107 germs /g soil), compared with Acacia raddiana (3.13 × 107 germs /g). This shows the stimulating effect of the vegetation on the increase in the rate of these microorganisms in the soil. Well as the strong Fitness of adaptation the microbial biomass to drought. Keywords: Argania spinoza; Acacia raddiana; rhizospheric soil; microbiology evaluation.

  15. [Effects of saline-alkali stress on electrical impedance spectroscopy parameters and ion contents in shoots of Ping'ou hybrid hazelnut].

    PubMed

    Zhang, Li; Jia, Zhi-Guo; Ma, Qing-Hua; Zhang, Gang; Wang, Gui-Xi

    2014-11-01

    To study the adaptability to salt-alkaline stress of Ping'ou hybrid hazelnut, 'Liaozhen 3' shoots which were treated with three types of stress neutral NaCl, alkaline Na2CO3, and mixed salt-alkali, and the changes in electrical impedance spectroscopy (EIS) parameters and mineral ion contents were subsequently determined. The correlations between the EIS parameters and mineral ion contents were analyzed. The results showed that with the increasing level of NaCl, specific high- frequency resistance (r), specific low-frequency resistance ( r(l)), specific intracellular resistance (r(i)) and specific extracellular resistance (r(e)) of shoots decreased firstly, then increased, and finally decreased again. However, these parameters increased gradually with the increasing level of Na2CO3, while r(l) and r(e) decreased slowly in the mixed salt-alkali treatments. The Na+ contents of shoots increased significantly under the three salt-alkali stresses with the order of NaCl stress > mixed salt-alkali stress > Na2CO3 stress. Furthermore, Na2CO3 stress resulted in the decreases in the contents of three elements Zn, B and Ca. The significant negative correlation was found between the sum of five cations and four EIS parameters r(l), r(e), relaxation time (τ) , and distribution coefficient of relaxation time (ψ). The shoots of 'Liaozhen 3' might be tolerant of Na2CO3 stress of 200 mmol · L(-1), while they could be resistant to NaCl stress of 100-150 mmol · L(-1). PMID:25898608

  16. Les fractures de jambe à fibula intact: traitement orthopédique ou enclouage centromédullaire? (étude comparative à propos de 60 cas)

    PubMed Central

    Abouchane, Merouane; Fadili, Assia; Belmoubarik, Amine; EL Andaloussi, Yassir; Nechad, Mohammed

    2015-01-01

    La fracture de jambe à fibula intact (FJFI) est caractérisée par un potentiel de déplacement minime ainsi le pronostic semble bon, souvent associées à des difficultés de réduction de consolidation ou de cal vicieux. Notre but est de comparer les résultats du traitement orthopédique et de l'enclouage centromédullaire (ECM). Entre janvier 2006 et janvier 2011, on a traité 60 fractures de jambe à fibula intact. 31 patients ont bénéficié d'un ECM, dont 14 fois était statique, 16 fois dynamique et simple une fois, avec un appui compris entre le 2eme jour (pour la plupart des patients) et la sixième semaine. 29 patients ont bénéficiés d'un traitement orthopédique après réduction par plâtre cruro-pédieux avec libération du genou après 4 semaines avec appui total chez la plupart des patients. La durée de consolidation été de 4 mois en moyenne pour les patients traites par ECM et de 6 mois pour les patients traites orthopédiquement. On a noté 3 cas de pseudarthrose dans notre série d’étude soit 5%: 2 observées chez le groupe de l'ECM soit 6,4% et un cas pour le groupe du traitement orthopédique soit 3,8%. 6 cas de déplacement secondaires ont été note chez les patients traites orhtopédiquement à j15 du traitement, pour 5 patients le déplacement été jugé tolérable et pour un seul patient (trouble angulaire supérieur à 10°) ayant nécessité un ECM. 13 cas soit 54% de cal vicieux angulaire supérieur à 10 dans notre série tous traités orthopédiquement versus aucun cas de cal vicieux chez les patients du groupe du traitement par ECM. Cliniquement: tous les patients traités par ECM ont présenté une mobilité du genou et de la cheville normale. Les patients traités orthopédiquement ont tous bénéficié d'une rééducation du genou libération du genou et confection d'un plâtre type Sarmiento et celle de la cheville après son ablation définitive, ainsi aucun de nos patients n'a gardé une raideur après avoir termin

  17. Approche au diagnostic de la maladie cœliaque chez les patients ayant une faible densité minérale osseuse ou des fractures de fragilité

    PubMed Central

    Rios, Lorena P.; Khan, Aliya; Sultan, Muhammad; McAssey, Karen; Fouda, Mona A.; Armstrong, David

    2013-01-01

    Résumé Objectif Présenter aux cliniciens une mise à jour sur le diagnostic de la maladie cœliaque (MC), ainsi que des recommandations sur les indications de procéder au dépistage de la MC chez les patients présentant une faible densité minérale osseuse (DMO) ou des fractures de fragilité. Qualité des données Un groupe de travail multidisciplinaire a élaboré des questions cliniquement pertinentes relativement au diagnostic de la MC servant de fondement à une recherche documentaire dans les bases de données MEDLINE, EMBASE et CENTRAL (de janvier 2000 à janvier 2009) à l’aide des mots clés en anglais celiac disease, osteoporosis, osteopenia, low bone mass et fracture. Les ouvrages scientifiques existants comportent des études de niveaux I et II. Message principal La prévalence estimée de la MC asymptomatique est de 2 % à 3 % chez les personnes qui ont une faible DMO. Par ailleurs, un dépistage ciblé est recommandé pour les patients qui ont des T-scores de −1,0 ou moins à la colonne vertébrale ou aux hanches ou des antécédents de fractures de fragilité associées à des symptômes ou à des problèmes reliés à la MC, des antécédents familiaux de MC ou de bas niveaux de calcium urinaire, une insuffisance en vitamine D et des niveaux à la hausse d’hormones parathyroïdiennes en dépit d’un apport suffisant en calcium et en vitamine D. Le dépistage de la MC devrait se faire pendant que le sujet consomme un régime alimentaire contenant du gluten. On procède au dépistage initial par le dosage d’immunoglobuline (Ig) A antitransglutaminase en utilisant la transglutaminase tissulaire humaine recombinante ou une autre transglutaminase tissulaire, en association avec l’immunofluorescence des IgA anti-endomysium. Une biopsie du duodénum est nécessaire pour confirmer le diagnostic de la MC. Le typage des antigènes des leucocytes humains peut aider à confirmer ou à exclure le diagnostic de la MC dans les cas où la s

  18. Successful Mnemonics for "por"/"para" and Affirmative Commands with Pronouns.

    ERIC Educational Resources Information Center

    Mason, Keith

    1992-01-01

    Two mnemonic devices, "4A Rule" and "PERFECT," are described to simplify the learning of two grammar points: the placement of object pronouns with respect to commands and the distinction between "por" and "para." (five references) (LB)

  19. Genome Sequences of Pseudomonas oryzihabitans Phage POR1 and Pseudomonas aeruginosa Phage PAE1.

    PubMed

    Dyson, Zoe A; Seviour, Robert J; Tucci, Joseph; Petrovski, Steve

    2016-01-01

    We report the genome sequences of two double-stranded DNA siphoviruses, POR1 infective for Pseudomonas oryzihabitans and PAE1 infective for Pseudomonas aeruginosa The phage POR1 genome showed no nucleotide sequence homology to any other DNA phage sequence in the GenBank database, while phage PAE1 displayed synteny to P. aeruginosa phages M6, MP1412, and YuA. PMID:27313312

  20. Genome Sequences of Pseudomonas oryzihabitans Phage POR1 and Pseudomonas aeruginosa Phage PAE1

    PubMed Central

    Dyson, Zoe A.; Seviour, Robert J.; Tucci, Joseph

    2016-01-01

    We report the genome sequences of two double-stranded DNA siphoviruses, POR1 infective for Pseudomonas oryzihabitans and PAE1 infective for Pseudomonas aeruginosa. The phage POR1 genome showed no nucleotide sequence homology to any other DNA phage sequence in the GenBank database, while phage PAE1 displayed synteny to P. aeruginosa phages M6, MP1412, and YuA. PMID:27313312

  1. Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition.

    PubMed

    Kattner, Christof; Toussi, Deana N; Zaucha, Jan; Wetzler, Lee M; Rüppel, Nadine; Zachariae, Ulrich; Massari, Paola; Tanabe, Mikio

    2014-03-01

    Among all Neisseriae species, Neisseria meningitidis and Neisseria gonorrhoeae are the only human pathogens, causative agents of bacterial meningitis and gonorrhoea, respectively. PorB, a pan-Neisseriae trimeric porin that mediates diffusive transport of essential molecules across the bacterial outer membrane, is also known to activate host innate immunity via Toll-like receptor 2 (TLR2)-mediated signaling. The molecular mechanism of PorB binding to TLR2 is not known, but it has been hypothesized that electrostatic interactions contribute to ligand/receptor binding. Strain-specific sequence variability in the surface-exposed loops of PorB which are potentially implicated in TLR2 binding, may explain the difference in TLR2-mediated cell activation in vitro by PorB homologs from the commensal Neisseriae lactamica and the pathogen N. meningitidis. Here, we report a comparative structural analysis of PorB from N. meningitidis serogroup B strain 8765 (63% sequence homology with PorB from N. meningitidis serogroup W135) and a mutant in which amino acid substitutions in the extracellular loop 7 lead to significantly reduced TLR2-dependent activity in vitro. We observe that this mutation both alters the loop conformation and causes dramatic changes of electrostatic surface charge, both of which may affect TLR2 recognition and signaling. PMID:24361688

  2. Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB

    SciTech Connect

    Tanabe, Mikio; Nimigean, Crina M.; Iverson, T.M.

    2010-06-25

    PorB is the second most prevalent outer membrane protein in Neisseria meningitidis. PorB is required for neisserial pathogenesis and can elicit a Toll-like receptor mediated host immune response. Here, the x-ray crystal structure of PorB has been determined to 2.3 {angstrom} resolution. Structural analysis and cocrystallization studies identify three putative solute translocation pathways through the channel pore: One pathway transports anions nonselectively, one transports cations nonselectively, and one facilitates the specific uptake of sugars. During infection, PorB likely binds host mitochondrial ATP, and cocrystallization with the ATP analog AMP-PNP suggests that binding of nucleotides regulates these translocation pathways both by partial occlusion of the pore and by restricting the motion of a putative voltage gating loop. PorB is located on the surface of N. meningitidis and can be recognized by receptors of the host innate immune system. Features of PorB suggest that Toll-like receptor mediated recognition outer membrane proteins may be initiated with a nonspecific electrostatic attraction.

  3. Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB

    PubMed Central

    Tanabe, Mikio; Nimigean, Crina M.; Iverson, T. M.

    2010-01-01

    PorB is the second most prevalent outer membrane protein in Neisseria meningitidis. PorB is required for neisserial pathogenesis and can elicit a Toll-like receptor mediated host immune response. Here, the x-ray crystal structure of PorB has been determined to 2.3 Å resolution. Structural analysis and cocrystallization studies identify three putative solute translocation pathways through the channel pore: One pathway transports anions nonselectively, one transports cations nonselectively, and one facilitates the specific uptake of sugars. During infection, PorB likely binds host mitochondrial ATP, and cocrystallization with the ATP analog AMP–PNP suggests that binding of nucleotides regulates these translocation pathways both by partial occlusion of the pore and by restricting the motion of a putative voltage gating loop. PorB is located on the surface of N. meningitidis and can be recognized by receptors of the host innate immune system. Features of PorB suggest that Toll-like receptor mediated recognition outer membrane proteins may be initiated with a nonspecific electrostatic attraction. PMID:20351243

  4. An investigation of exploitation versus exploration in GBEA optimization of PORS 15 and 16 Problems

    SciTech Connect

    Koch, Kaelynn

    2012-01-01

    It was hypothesized that the variations in time to solution are driven by the competing mechanisms of exploration and exploitation.This thesis explores this hypothesis by examining two contrasting problems that embody the hypothesized tradeoff between exploration and exploitation. Plus one recall store (PORS) is an optimization problem based on the idea of a simple calculator with four buttons: plus, one, store, and recall. Integer addition and store are classified as operations, and one and memory recall are classified as terminals. The goal is to arrange a fixed number of keystrokes in a way that maximizes the numerical result. PORS 15 (15 keystrokes) represents the subset of difficult PORS problems and PORS 16 (16 keystrokes) represents the subset of PORS problems that are easiest to optimize. The goal of this work is to examine the tradeoff between exploitation and exploration in graph based evolutionary algorithm (GBEA) optimization. To do this, computational experiments are used to examine how solutions evolve in PORS 15 and 16 problems when solved using GBEAs. The experiment is comprised of three components; the graphs and the population, the evolutionary algorithm rule set, and the example problems. The complete, hypercube, and cycle graphs were used for this experiment. A fixed population size was used.

  5. Complications du diverticule de Meckel (DM) chez l'adulte: à propos de 11 cas au CHU-Yalgado Ouédraogo au Burkina Faso

    PubMed Central

    Ouangré, Edgar; Zida, Maurice; Bazongo, Moussa; Sanou, Adama; Bonkoungou, Gilbert Patindé; Doamba, Rodrigue Namékinsba; Sawadogo, Elie Yamba; Ouédraogo, Sidziguin; Zongo, Nayi; Traore, Si Simon

    2015-01-01

    Le diverticule de Meckel (DM) est la persistance partielle du canal omphalomésentérique. Ses complications sont rares. Le diagnostic est le plus souvent per opératoire. L'objectif a été de décrire les complications du diverticule de Meckel chez l'adulte dans le service de chirurgie générale et digestive du CHU Yalgado Ouédraogo. Il s'est agi d'une étude transversale descriptive sur 10 ans (janvier 2004-décembre 2013) portant sur les dossiers des patients âgés de plus de 15 ans ayant présenté un DM compliqué. Durant la période d’étude, 11 cas ont été colligés. L'incidence annuelle a été de 11 cas. Nous avons noté une prédominance masculine avec un sex-ratio de 4,5. L’âge moyen des patients était de 29,8 ans. Le diagnostic préopératoire a été dans huit cas une occlusion intestinale aiguë, une appendicite aiguë dans deux cas, une péritonite aiguë généralisée dans un cas. Il a été diagnostiqué en peropératoire une occlusion intestinale dans neuf cas; une diverticulite dans un cas et un cas de perforation du DM. Tous les DM avaient été réséqués dont huit résections segmentaires iléales emportant le DM et trois résections cunéiformes. Tous les DM étaient situés à moins d'un mètre de la jonction iléo-caecale. L'histologie réalisée dans deux cas avait conclu à une diverticulite. Les suites opératoires ont été simples dans neuf cas, compliquées dans deux cas dont une éventration et un décès. Les complications du diverticule de Meckel sont rares. Le diagnostic préopératoire est difficile. Le traitement est essentiellement chirurgical. PMID:26958137

  6. Astronomy in the Classroom: Why? (Spanish Title: Astronomía en la Clase: ¿Por Qué?) Astronomia na Sala de Aula: Por Quê?

    NASA Astrophysics Data System (ADS)

    Daros Gama, Leandro; Bagdonas Henrique, Alexandre

    2010-07-01

    There are many discussions about the relevance of the topics covered in classes. One subject in particular is the focus of this essay: astronomy. In what sense and to what extent it would be worth to teach it in science or other kind of classes? In this paper we discuss some aspects of the advantages of dealing with this area of knowledge in schools, taking into account the epistemological and axiological dimensions of astronomy, in light of the vision of science as an intelligent dialogue with the world (Bachelard), in addition to the "problematization" knowledge of Paulo Freire. We propose that in fact the Astronomy does not need to be seen as just a new set of contents to be taught, but appears as a set of motivational contents for historical-philosophical discussions, and permit the discussion of concepts of other disciplines. Numerosas discusiones se están llevando a cabo acerca de la pertinencia de los temas tradicionalmente tratados en las clases. Uno de los temas, en particular, es el foco de este ensayo: la astronomía. ¿En qué sentido y en qué medida sería conveniente tratarla en clase, ya sea en clases de ciencias naturales, específicamente en las de astronomía o asignaturas afines? Elaboramos en este artículo algunos aspectos de las ventajas de tratar esta área del conocimiento en las escuelas, teniendo en cuenta las dimensiones epistemológica y axiológica de la astronomía, a la luz de la visión de la ciencia como un diálogo inteligente con el mundo (Bachelard), además de la propuesta del conocimiento "problematizador" de Paulo Freire. Proponemos que en realidad la astronomía no tiene por qué ser vista sólo como un nuevo conjunto de contenidos que se enseñan, sino que aparece como un conjunto de temas de motivación para el debate histórico-filosófico y para permitir la discusión de los conceptos típicos de otras disciplinas. Muitas discussões vêm acontecendo sobre a relevância dos temas abordados em sala de aula. Um tema, em

  7. Molecular characterisation of Porcine rubulavirus (PorPV) isolates from different outbreaks in Mexico.

    PubMed

    Cuevas-Romero, S; Rivera-Benítez, J F; Blomström, A-L; Ramliden, M; Hernández-Baumgarten, E; Hernández-Jáuregui, P; Ramírez-Mendoza, H; Berg, M

    2016-02-01

    Since the report of the initial outbreak of Porcine rubulavirus (PorPV) infection in pigs, only one full-length genome from 1984 (PorPV-LPMV/1984) has been characterised. To investigate the overall genetic variation, full-length gene nucleotide sequences of current PorPV isolates were obtained from different clinical cases of infected swine. Genome organisation and sequence analysis of the encoded proteins (NP, P, F, M, HN and L) revealed high sequence conservation of the NP protein and the expression of the P and V proteins in all PorPV isolates. The V protein of one isolate displayed a mutation that has been implicated to antagonise the antiviral immune responses of the host. The M protein indicated a variation in a short region that could affect the electrostatic charge and the interaction with the membrane. One PorPV isolate recovered from the lungs showed a mutation at the cleavage site (HRKKR) of the F protein that could represent an important factor to determine the tissue tropism and pathogenicity of this virus. The HN protein showed high sequence identity through the years (up to 2013). Additionally, a number of sequence motifs of very high amino acid conservation among the PorPV isolates important for polymerase activity of the L protein have been identified. In summary, genetic comparisons and phylogenetic analyses indicated that three different genetic variants of PorPV are currently spreading within the swine population, and a new generation of circulating virus with different characteristics has begun to emerge. PMID:26728078

  8. Por Secretion System-Dependent Secretion and Glycosylation of Porphyromonas gingivalis Hemin-Binding Protein 35

    PubMed Central

    Shoji, Mikio; Sato, Keiko; Yukitake, Hideharu; Kondo, Yoshio; Narita, Yuka; Kadowaki, Tomoko; Naito, Mariko; Nakayama, Koji

    2011-01-01

    The anaerobic Gram-negative bacterium Porphyromonas gingivalis is a major pathogen in severe forms of periodontal disease and refractory periapical perodontitis. We have recently found that P. gingivalis has a novel secretion system named the Por secretion system (PorSS), which is responsible for secretion of major extracellular proteinases, Arg-gingipains (Rgps) and Lys-gingipain. These proteinases contain conserved C-terminal domains (CTDs) in their C-termini. Hemin-binding protein 35 (HBP35), which is one of the outer membrane proteins of P. gingivalis and contributes to its haem utilization, also contains a CTD, suggesting that HBP35 is translocated to the cell surface via the PorSS. In this study, immunoblot analysis of P. gingivalis mutants deficient in the PorSS or in the biosynthesis of anionic polysaccharide-lipopolysaccharide (A-LPS) revealed that HBP35 is translocated to the cell surface via the PorSS and is glycosylated with A-LPS. From deletion analysis with a GFP-CTD[HBP35] green fluorescent protein fusion, the C-terminal 22 amino acid residues of CTD[HBP35] were found to be required for cell surface translocation and glycosylation. The GFP-CTD fusion study also revealed that the CTDs of CPG70, peptidylarginine deiminase, P27 and RgpB play roles in PorSS-dependent translocation and glycosylation. However, CTD-region peptides were not found in samples of glycosylated HBP35 protein by peptide map fingerprinting analysis, and antibodies against CTD-regions peptides did not react with glycosylated HBP35 protein. These results suggest both that the CTD region functions as a recognition signal for the PorSS and that glycosylation of CTD proteins occurs after removal of the CTD region. Rabbits were used for making antisera against bacterial proteins in this study. PMID:21731719

  9. Gliding Motility and Por Secretion System Genes Are Widespread among Members of the Phylum Bacteroidetes

    PubMed Central

    Zhu, Yongtao

    2013-01-01

    The phylum Bacteroidetes is large and diverse, with rapid gliding motility and the ability to digest macromolecules associated with many genera and species. Recently, a novel protein secretion system, the Por secretion system (PorSS), was identified in two members of the phylum, the gliding bacterium Flavobacterium johnsoniae and the nonmotile oral pathogen Porphyromonas gingivalis. The components of the PorSS are not similar in sequence to those of other well-studied bacterial secretion systems. The F. johnsoniae PorSS genes are a subset of the gliding motility genes, suggesting a role for the secretion system in motility. The F. johnsoniae PorSS is needed for assembly of the gliding motility apparatus and for secretion of a chitinase, and the P. gingivalis PorSS is involved in secretion of gingipain protease virulence factors. Comparative analysis of 37 genomes of members of the phylum Bacteroidetes revealed the widespread occurrence of gliding motility genes and PorSS genes. Genes associated with other bacterial protein secretion systems were less common. The results suggest that gliding motility is more common than previously reported. Microscopic observations confirmed that organisms previously described as nonmotile, including Croceibacter atlanticus, “Gramella forsetii,” Paludibacter propionicigenes, Riemerella anatipestifer, and Robiginitalea biformata, exhibit gliding motility. Three genes (gldA, gldF, and gldG) that encode an apparent ATP-binding cassette transporter required for F. johnsoniae gliding were absent from two related gliding bacteria, suggesting that the transporter may not be central to gliding motility. PMID:23123910

  10. Cas rare de rupture bilatérale des tendons d'Achille sans notion de tendinopathie ou de chirurgie de la cheville chez un jeune sportif: à propos d'un cas et revue de la literature

    PubMed Central

    Belmoubarik, Amine; Abouchane, Merouane; Mahraoui, Mohamed Amine

    2015-01-01

    Les lésions du tendon d'Achille sont plus fréquentes que celles du tendon quadricipital ou patellaire. Les lésions bilatérales sont par contre plus rares et sont souvent associées à une notion de tendinopathie, d'injection de corticoïdes ou de maladies systémiques tels que le lupus érythémateux, l'ostéomalacie ou l'insuffisance rénale chronique. Nous rapportons le cas d'un patient de 34 ans victime d'une rupture bilatérale des tendons d'Achille suite à une réception de saut lors de la pratique de gymnastique. Le patient n’était pas suivi pour maladie de système ou mis sous corticothérapie ou fluoroquinolones. Le diagnostic a été suspecté devant une dépression anormalement creusant le relief sous cutané des deux tendons d'Achille avec une impossibilité de flexion dorsale des deux chevilles en association à un signe de Thompson bilatéralement positif. L’échographie a confirmé le diagnostic. Le patient a été traité par laçage et suture tendineuse à ciel ouvert. La rupture bilatérale du tendon d'Achille est rare. La plupart des patients rapportent une notion de maladie systémique ou un antécédent de chirurgie du genou. Nous rapportons le cas d'une lésion rare dans la littérature, une rupture bilatérale des tendons achiléens sans notions de maladies auto-immunes ni de traitement aux corticoïdes. Les lésions bilatérales présentent certaines particularités thérapeutiques et évolutives. En effet, deux difficultés sont à noter la première réside dans l'absence de référence comparative pour régler et apprécier l’équin physiologique lors de la réparation tendineuse. La deuxième difficulté est l'obligation de différer l'appui à 45 jours. Ce qui est contraignant pour le patient. La technique de réparation à ciel ouvert couplée à une immobilisation en équin protégeant la suture nous a donné des résultats satisfaisants. PMID:26140066

  11. Slug Test Characterization Results for Multi-Test/Depth Intervals Conducted During the Drilling of CERCLA Operable Unit OU ZP-1 Wells 299-W10-33 and 299-W11-48

    SciTech Connect

    Newcomer, Darrell R.

    2007-09-30

    Slug-test results obtained from single and multiple, stress-level slug tests conducted during drilling and borehole advancement provide detailed hydraulic conductivity information at two Hanford Site Operable Unit (OU) ZP-1 test well locations. The individual test/depth intervals were generally sited to provide hydraulic-property information within the upper ~10 m of the unconfined aquifer (i.e., Ringold Formation, Unit 5). These characterization results complement previous and ongoing drill-and-test characterization programs at surrounding 200-West and -East Area locations (see Figure S.1).

  12. Un exemple de volcanisme calco-alcalin de type orogénique mis en place en contexte de rifting (Cambrien de l'oued Rhebar, Meseta occidentale, Maroc)

    NASA Astrophysics Data System (ADS)

    El Hadi, Hassan; Tahiri, Abdelfatah; Simancas Cabrera, Fernando; González Lodeiro, Francisco; Azor Pérez, Antonio; Jesús Martínez Poyatos, David

    2006-03-01

    The Middle Cambrian calc-alkaline Oued Rhebar volcanic complex (western Meseta, Morocco) compares with rocks originated in orogenic contexts. The La/Nb ratios are relatively high (5.2), suggesting a lithospheric mantle origin. The La/Ta ratios, higher than 26, and the negative Nb anomaly indicate a lithospheric source contaminated by the continental crust. These rocks were generated in the Mesetian Mid-Cambrian rift and would have inherited their orogenic signature from the partial melting of a previously metasomatized mantle. To cite this article: H. El Hadi et al., C. R. Geoscience 338 (2006).

  13. Oral administration of recombinant Neisseria meningitidis PorA genetically fused to H. pylori HpaA antigen increases antibody levels in mouse serum, suggesting that PorA behaves as a putative adjuvant.

    PubMed

    Vasquez, Abel E; Manzo, Ricardo A; Soto, Daniel A; Barrientos, Magaly J; Maldonado, Aurora E; Mosqueira, Macarena; Avila, Anastasia; Touma, Jorge; Bruce, Elsa; Harris, Paul R; Venegas, Alejandro

    2015-01-01

    The Neisseria meningitidis outer membrane protein PorA from a Chilean strain was purified as a recombinant protein. PorA mixed with AbISCO induced bactericidal antibodies against N. meningitidis in mice. When PorA was fused to the Helicobacter pylori HpaA antigen gene, the specific response against H. pylori protein increased. Splenocytes from PorA-immunized mice were stimulated with PorA, and an increase in the secretion of IL-4 was observed compared with that of IFN-γ. Moreover, in an immunoglobulin sub-typing analysis, a substantially higher IgG1 level was found compared with IgG2a levels, suggesting a Th2-type immune response. This study revealed a peculiar behavior of the purified recombinant PorA protein per se in the absence of AbISCO as an adjuvant. Therefore, the resistance of PorA to proteolytic enzymes, such as those in the gastrointestinal tract, was analyzed, because this is an important feature for an oral protein adjuvant. Finally, we found that PorA fused to the H. pylori HpaA antigen, when expressed in Lactococcus lactis and administered orally, could enhance the antibody response against the HpaA antigen approximately 3 fold. These observations strongly suggest that PorA behaves as an effective oral adjuvant. PMID:25750999

  14. Oral administration of recombinant Neisseria meningitidis PorA genetically fused to H. pylori HpaA antigen increases antibody levels in mouse serum, suggesting that PorA behaves as a putative adjuvant

    PubMed Central

    Vasquez, Abel E; Manzo, Ricardo A; Soto, Daniel A; Barrientos, Magaly J; Maldonado, Aurora E; Mosqueira, Macarena; Avila, Anastasia; Touma, Jorge; Bruce, Elsa; Harris, Paul R; Venegas, Alejandro

    2015-01-01

    The Neisseria meningitidis outer membrane protein PorA from a Chilean strain was purified as a recombinant protein. PorA mixed with AbISCO induced bactericidal antibodies against N. meningitidis in mice. When PorA was fused to the Helicobacter pylori HpaA antigen gene, the specific response against H. pylori protein increased. Splenocytes from PorA-immunized mice were stimulated with PorA, and an increase in the secretion of IL-4 was observed compared with that of IFN-γ. Moreover, in an immunoglobulin sub-typing analysis, a substantially higher IgG1 level was found compared with IgG2a levels, suggesting a Th2-type immune response. This study revealed a peculiar behavior of the purified recombinant PorA protein per se in the absence of AbISCO as an adjuvant. Therefore, the resistance of PorA to proteolytic enzymes, such as those in the gastrointestinal tract, was analyzed, because this is an important feature for an oral protein adjuvant. Finally, we found that PorA fused to the H. pylori HpaA antigen, when expressed in Lactococcus lactis and administered orally, could enhance the antibody response against the HpaA antigen approximately 3 fold. These observations strongly suggest that PorA behaves as an effective oral adjuvant. PMID:25750999

  15. An Analysis of Interlanguage Development Over Time: Part 1, "por" and "para".

    ERIC Educational Resources Information Center

    Guntermann, Gail

    1992-01-01

    The first part of a larger planned investigation, this study examines the use of "por" and "para" by nine Peace Corps volunteers in oral interviews at the end of training and roughly one year later, to trace their acquisition over time, in two learning contexts. (24 references) (LB)

  16. The Acquisition of Lexical Meaning in a Study Abroad Context: The Spanish Prepositions "por" and "para."

    ERIC Educational Resources Information Center

    Lafford, Barbara A.; Ryan, John M.

    1995-01-01

    Examination of the development of form/function relations of the prepositions "por" and "para" at different levels of proficiency in the interlanguage of study-abroad students in Granada, Spain, revealed "noncanonical" as well as "canonical" uses of these prepositions. The most common noncanonical uses were as substitutions for other prepositions…

  17. The porA gene in serogroup A meningococci: evolutionary stability and mechanism of genetic variation.

    PubMed

    Suker, J; Feavers, I M; Achtman, M; Morelli, G; Wang, J F; Maiden, M C

    1994-04-01

    Molecular analyses were applied to the genes encoding variants of the serosubtyping antigen, the class 1 outer membrane protein (PorA), from 55 serogroup A Neisseria meningitidis strains. These genes were evolutionarily stable and exhibited a limited range of genetic variation, primarily generated by recombination. Translation of the gene sequences revealed a total of 19 distinct amino acid sequences in the variable regions of the protein, 6 of which were not recognized by currently available serosubtyping monoclonal antibodies. Knowledge of these amino acid sequences permitted a rational re-assignment of serosubtype names. Comparison of the complete genes with porA gene sequences from serogroup B and C meningococci showed that serogroup A possessed a limited number of the possible porA genes from a globally distributed gene pool. Each serogroup A subgroup was characterized by one of four porA gene types, probably acquired upon subgroup divergence, which was stable over periods of decades and during epidemiological spread. Comparison with other variable genes (pil and iga) indicated that the three alleles were independently assorted within the subgroup, suggesting that their gene types were older than the subgroups in which they occurred. PMID:8057850

  18. Informe a la Nación de mortalidad por cáncer sigue bajando

    Cancer.gov

    El Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2009, indica que los índices generales de mortalidad por cáncer siguen bajando en los Estados Unidos en hombres y mujeres, entre todos los grupos raciales y étnicos principales y para todo

  19. Detección y estudio mediante Fluorescencia Inducida por Láser de radicales libres formados por Disociación Multifotónica Infrarroja

    NASA Astrophysics Data System (ADS)

    Santos, M.; Díaz, L.; Torresano, J. A.; Rubio, L.; Samoudi, B.

    Una de las principales aplicaciones actuales de los procesos de disociación multifotónica inducidos por radiación láser infrarroja (DMI) es la producción de radiales libres, con el fin de estudiar sus propiedades cinéticas y espectroscópicas. La disociación de moléculas poliatómicas en el IR con láseres de CO2 tiene lugar desde la superficie de energía molecular mas baja y conduce generalmente a la formación de fragmentos en el estado electrónico fundamental, con diversos grados de excitación vibracional. En el Grupo de Procesos Multifotónicos del Instituto de Estructura de la Materia del C.S.I.C. hemos puesto a punto la técnica de Fluorescencia Inducida por Láser (LIF) para la detección y análisis en tiempo real de los fragmentos producidos en la DMI inducida mediante uno o dos campos láseres de diferentes longitudes de onda. Objetivos de nuestro trabajo han sido el estudio de los canales de disociación mayoritarios y de las especies transitoria producidas, así como de la distribución de energía interna con que éstas son generadas. En particular hemos detectado mediante LIF las especies: C2, CF, CH, SiH2, CF2, CH2, SiHCl, y CF3 a partir de la disociación de, entre otras, las siguientes moléculas: C2H3Br, C3F6, C4H8Si, C2H5ClSi y CH5ClSi. En este trabajo presentamos algunos de los resultados obtenidos mediante el estudio por LIF de estos radicales: estudio temporal de la señal LIF obtenida con determinación de tiempos de vida, espectros de excitación y fluorescencia, temperaturas vibracionales de formación, variación de la intensidad LIF con el tiempo de retraso entre los láseres de disociación y prueba, etc.

  20. ATP for the portable 500 CFM exhauster POR-005 skid C

    SciTech Connect

    Keller, C.M.

    1997-06-27

    This Acceptance Test Plan is for a 500 CFM Portable Exhauster POR-005 to be used for saltwell pumping. The Portable Exhauster System will be utilized to eliminate potential flammable gases that may exist within the dome space of the tank. This Acceptance Plan will test and verify that the exhauster meets the specified design criteria, safety requirements, operations requirements, and will provide a record of the functional test results.

  1. ATP for the portable 500 CFM exhauster POR-006 skid D

    SciTech Connect

    Keller, C.M.

    1997-07-29

    This Acceptance Test Plan is for a 500 CFM Portable Exhauster POR-006 to be used for saltwell pumping. The Portable Exhauster System will be utilized to eliminate potential flammable gases that may exist within the dome space of the tank. This Acceptance Plan will test and verify that the exhauster meets the specified design criteria, safety requirements, operations requirements, and will provide a record of the functional test results.

  2. ATP for the portable 500 CFM exhauster POR-004 skid B

    SciTech Connect

    Keller, C.M.

    1997-05-06

    This Acceptance Test Plan is for a 500 CFM Portable Exhauster POR-004 to be used for saltwell pumping. The Portable Exhauster System will be utilized to eliminate potential flammable gases that may exist within the dome space of the tank. This Acceptance Plan will test and verify that the exhauster meets the specified design criteria, safety requirements, operations requirements, and will provide a record of the functional test results.

  3. Correlation between Serological and Sequencing Analyses of the PorB Outer Membrane Protein in the Neisseria meningitidis Serotyping System

    PubMed Central

    Sacchi, Claudio T.; Lemos, Ana P. S.; Whitney, Anne M.; Solari, Claude A.; Brandt, Mary E.; Melles, Carmo E. A.; Frasch, Carl E.; Mayer, Leonard W.

    1998-01-01

    The current serological typing scheme for Neisseria meningitidis is not comprehensive; a proportion of isolates are not serotypeable. DNA sequence analysis and predicted amino acid sequences were used to characterize the structures of variable-region (VR) epitopes on N. meningitidis PorB proteins (PorB VR typing). Twenty-six porB gene sequences were obtained from GenBank and aligned with 41 new sequences. Primary amino acid structures predicted from those genes were grouped into 30 VR families of related variants that displayed at least 60% similarity. We correlated VR families with monoclonal antibody (MAb) reactivities, establishing a relationship between VR families and epitope locations for 15 serotype-defining MAbs. The current panel of serotype-defining MAbs underestimates by at least 50% the PorB VR variability because reagents for several major VR families are lacking or because a number of VR variants within some families are not recognized by serotype-defining MAbs. These difficulties, also reported for serosubtyping based on the PorA protein, are shown as inconsistent results between serological and sequence analyses, leading to inaccurate strain identification and incomplete epidemiological data. The information from this study enabled the expansion of the panel of MAbs currently available for serotyping, by including MAbs of previously undetermined specificities. Use of the expanded serotype panel enabled us to improve the sensitivity of serotyping by resolving a number of formerly nonserotypeable strains. In most cases, this information can be used to predict the VR family placement of unknown PorB proteins without sequencing the entire porB gene. PorB VR typing complements serotyping, and a combination of both techniques may be used for full characterization of meningococcal strains. The present work represents the most complete and integrated data set of PorB VR sequences and MAb reactivities of serogroup B and C meningococci produced to date. PMID

  4. Zinc Finger Nuclease Knock-out of NADPH:Cytochrome P450 Oxidoreductase (POR) in Human Tumor Cell Lines Demonstrates That Hypoxia-activated Prodrugs Differ in POR Dependence*

    PubMed Central

    Su, Jiechuang; Gu, Yongchuan; Pruijn, Frederik B.; Smaill, Jeff B.; Patterson, Adam V.; Guise, Christopher P.; Wilson, William R.

    2013-01-01

    Hypoxia, a ubiquitous feature of tumors, can be exploited by hypoxia-activated prodrugs (HAP) that are substrates for one-electron reduction in the absence of oxygen. NADPH:cytochrome P450 oxidoreductase (POR) is considered one of the major enzymes responsible, based on studies using purified enzyme or forced overexpression in cell lines. To examine the role of POR in HAP activation at endogenous levels of expression, POR knock-outs were generated in HCT116 and SiHa cells by targeted mutation of exon 8 using zinc finger nucleases. Absolute quantitation by proteotypic peptide mass spectrometry of DNA sequence-confirmed multiallelic mutants demonstrated expression of proteins with residual one-electron reductase activity in some clones and identified two (Hko2 from HCT116 and S2ko1 from SiHa) that were functionally null by multiple criteria. Sensitivities of the clones to 11 HAP (six nitroaromatics, three benzotriazine N-oxides, and two quinones) were compared with wild-type and POR-overexpressing cells. All except the quinones were potentiated by POR overexpression. Knocking out POR had a marked effect on antiproliferative activity of the 5-nitroquinoline SN24349 in both genetic backgrounds after anoxic exposure but little or no effect on activity of most other HAP, including the clinical stage 2-nitroimidazole mustard TH-302, dinitrobenzamide mustard PR-104A, and benzotriazine N-oxide SN30000. Clonogenic cell killing and reductive metabolism of PR-104A and SN30000 under anoxia also showed little change in the POR knock-outs. Thus, although POR expression is a potential biomarker of sensitivity to some HAP, identification of other one-electron reductases responsible for HAP activation is needed for their rational clinical development. PMID:24196959

  5. Characterization of Plasmid pOR1 from Ornithobacterium rhinotracheale and Construction of a Shuttle Plasmid

    PubMed Central

    Jansen, Ruud; Chansiripornchai, Niwat; Gaastra, Wim; van Putten, Jos P. M.

    2004-01-01

    The bacterium Ornithobacterium rhinotracheale has been recognized as an emerging pathogen in poultry since about 10 years ago. Knowledge of this bacterium and its mechanisms of virulence is still very limited. Here we report the development of a transformation system that enables genetic modification of O. rhinotracheale. The system is based on a cryptic plasmid, pOR1, that was derived from an O. rhinotracheale strain of serotype K. Sequencing indicated that the plasmid consisted of 14,787 nucleotides. Sequence analysis revealed one replication origin and several rep genes that control plasmid replication and copy number, respectively. In addition, pOR1 contains genes with similarity to a heavy-metal-transporting ATPase, a TonB-linked siderophore receptor, and a laccase. Reverse transcription-PCR demonstrated that these genes were transcribed. Other putative open reading frames exhibited similarities with a virulence-associated protein in Actinobacillus actinomycetemcomitans and a number of genes coding for proteins with unknown function. An Escherichia coli-O. rhinotracheale shuttle plasmid (pOREC1) was constructed by cloning the replication origin and rep genes from pOR1 and the cfxA gene from Bacteroides vulgatus, which codes for resistance to the antibiotic cefoxitin, into plasmid pGEM7 by using E. coli as a host. pOREC1 was electroporated into O. rhinotracheale and yielded cefoxitin-resistant transformants. The pOREC1 isolated from these transformants was reintroduced into E. coli, demonstrating that pOREC1 acts as an independent replicon in both E. coli and O. rhinotracheale, fulfilling the criteria for a shuttle plasmid that can be used for transformation, targeted mutagenesis, and the construction of defined attenuated vaccine strains. PMID:15466524

  6. Expression, purification and preliminary X-ray analysis of the Neisseria meningitidis outer membrane protein PorB

    SciTech Connect

    Tanabe, Mikio; Iverson, Tina M.

    2010-01-28

    The Neisseria meningitidis outer membrane protein PorB was expressed in Escherichia coli and purified from inclusion bodies by denaturation in urea followed by refolding in buffered LDAO on a size-exclusion column. PorB has been crystallized in three different crystal forms: C222, R32 and P6{sub 3}. The C222 crystal form may contain either one or two PorB monomers in the asymmetric unit, while both the R32 and P6{sub 3} crystal forms contained one PorB monomer in the asymmetric unit. Of the three, the P6{sub 3} crystal form had the best diffraction quality, yielding data extending to 2.3 {angstrom} resolution.

  7. Application of POR-Tveks to the radiochemical recovery of yttrium-90

    SciTech Connect

    Maksimova, A.M.; Kvasnitskii, I.B.

    1988-01-01

    The authors describe a method for the radiochemical analysis of fish bones for the accumulation of strontium 90 and yttrium 90 from power plant contamination of surface waters which involves labelling the sample with isotopes and subsequent adsorption of the yttrium component with the use of POR-Tveks, an adsorbent based on a copolymer of styrene and divinylbenzene with heteroradical phosphine oxide. The yield of yttrium is determined from the mass of the oxide and from the half-life of the yttrium isotope.

  8. Antigenic topology of chlamydial PorB protein and identification of targets for immune neutralization of infectivity.

    PubMed

    Kawa, Diane E; Stephens, Richard S

    2002-05-15

    The outer membrane protein PorB is a conserved chlamydial protein that functions as a porin and is capable of eliciting neutralizing Abs. A topological antigenic map was developed using overlapping synthetic peptides representing the Chlamydia trachomatis PorB sequence and polyclonal immune sera. To identify which antigenic determinants were surface accessible, monospecific antisera were raised to the PorB peptides and were used in dot-blot and ELISA-based absorption studies with viable chlamydial elementary bodies (EBs). The ability of the surface-accessible antigenic determinants to direct neutralizing Ab responses was investigated using standardized in vitro neutralization assays. Four major antigenic clusters corresponding to Phe(34)-Leu(59) (B1-2 and B1-3), Asp(112) -Glu(145) (B2-3 and B2-4), Gly(179)-Ala(225) (B3-2 to B3-4), and Val(261)-Asn(305) (B4-4 to B5-2) were identified. Collectively, the EB absorption and dot-blot assays established that the immunoreactive PorB Ags were exposed on the surface of chlamydial EBs. Peptide-specific antisera raised to the surface-accessible Ags neutralized chlamydial infectivity and demonstrated cross-reactivity to synthetic peptides representing analogous C. pneumoniae PorB sequences. Furthermore, neutralization of chlamydial infectivity by C. trachomatis PorB antisera was inhibited by synthetic peptides representing the surface-exposed PorB antigenic determinants. These findings demonstrate that PorB Ags may be useful for development of chlamydial vaccines. PMID:11994474

  9. Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (POR).

    PubMed

    Menon, Binuraj R K; Hardman, Samantha J O; Scrutton, Nigel S; Heyes, Derren J

    2016-08-01

    Protochlorophyllide oxidoreductase (POR) catalyzes the light-driven reduction of protochlorophyllide (Pchlide), an essential, regulatory step in chlorophyll biosynthesis. The unique requirement of the enzyme for light has provided the opportunity to investigate how light energy can be harnessed to power biological catalysis and enzyme dynamics. Excited state interactions between the Pchlide molecule and the protein are known to drive the subsequent reaction chemistry. However, the structural features of POR and active site residues that are important for photochemistry and catalysis are currently unknown, because there is no crystal structure for POR. Here, we have used static and time-resolved spectroscopic measurements of a number of active site variants to study the role of a number of residues, which are located in the proposed NADPH/Pchlide binding site based on previous homology models, in the reaction mechanism of POR. Our findings, which are interpreted in the context of a new improved structural model, have identified several residues that are predicted to interact with the coenzyme or substrate. Several of the POR variants have a profound effect on the photochemistry, suggesting that multiple residues are important in stabilizing the excited state required for catalysis. Our work offers insight into how the POR active site geometry is finely tuned by multiple active site residues to support enzyme-mediated photochemistry and reduction of Pchlide, both of which are crucial to the existence of life on Earth. PMID:27285815

  10. Diagnóstico diferencial en la encefalitis por anticuerpos contra el receptor NMDA

    PubMed Central

    González-Valcárcel, J.; Rosenfeld, M.R.; Dalmau, J.

    2011-01-01

    Resumen Introducción La encefalitis por anticuerpos contra el receptor de NMDA (NMDAR) suele desarrollarse como un síndrome característico de evolución multifásica y diagnóstico diferencial amplio. Pacientes Presentamos a 2 pacientes diagnosticadas de encefalitis por anticuerpos NMDAR con un cuadro clínico típico, pero que inicialmente señaló otras etiologías. Discusión La afectación frecuente de pacientes jóvenes con manifestaciones psiquiátricas prominentes indica frecuentemente otras consideraciones diagnósticas; las más frecuentes son las encefalitis virales, los procesos psiquiátricos y el síndrome neuroléptico maligno. Varios síndromes previamente definidos de manera parcial o descriptiva en adultos y pacientes pediátricos probablemente eran casos de encefalitis anti-NMDAR. Conclusiones La encefalitis anti-NMDAR debe considerarse en pacientes jóvenes con manifestaciones psiquiátricas subagudas, movimientos anormales y alteraciones autonómicas. La caracterización clínica e inmunológica de esta enfermedad ha llevado a la identificación de nuevos anticuerpos que afectan a procesos de memoria, aprendizaje, conducta y psicosis. PMID:20964986

  11. Effect of SPM-based cleaning POR on EUV mask performance

    NASA Astrophysics Data System (ADS)

    Choi, Jaehyuck; Lee, Han-shin; Yoon, Jinsang; Shimomura, Takeya; Friz, Alex; Montgomery, Cecilia; Ma, Andy; Goodwin, Frank; Kang, Daehyuk; Chung, Paul; Shin, Inkyun; Cho, H.

    2011-11-01

    EUV masks include many different layers of various materials rarely used in optical masks, and each layer of material has a particular role in enhancing the performance of EUV lithography. Therefore, it is crucial to understand how the mask quality and patterning performance can change during mask fabrication, EUV exposure, maintenance cleaning, shipping, or storage. The fact that a pellicle is not used to protect the mask surface in EUV lithography suggests that EUV masks may have to undergo more cleaning cycles during their lifetime. More frequent cleaning, combined with the adoption of new materials for EUV masks, necessitates that mask manufacturers closely examine the performance change of EUV masks during cleaning process. We have investigated EUV mask quality and patterning performance during 30 cycles of Samsung's EUV mask SPM-based cleaning and 20 cycles of SEMATECH ADT exposure. We have observed that the quality and patterning performance of EUV masks does not significantly change during these processes except mask pattern CD change. To resolve this issue, we have developed an acid-free cleaning POR and substantially improved EUV mask film loss compared to the SPM-based cleaning POR.

  12. Methodology for obtaining stakeholder assessments of obesity policy options in the PorGrow project.

    PubMed

    Stirling, A; Lobstein, T; Millstone, E

    2007-05-01

    The Policy Options for Responding to the Growing Challenge of Obesity Research Project (PorGrow) study provided a unique opportunity to develop a large-scale application of a semi-quantitative technique for exploring interviewees' views on options to tackle obesity, using multi-criteria mapping. This 'heuristic' approach utilizes the advantages of a structured interviews framework by predefining a set of options for appraisal, while leaving interviewees free to select their own criteria for making their judgements. Additional information can be gleaned from the interview transcripts and related materials to set the appraisals in their policy context, and allowing interviewees to express their views on the options presented and their own appraisals. The PorGrow study team agreed a predefined set of 20 options for appraisal, and interviewed sets of stakeholders representing more than 20 aspects of policy development in each of the nine participating countries. The details of the methodology adopted are set out in this paper. PMID:17371304

  13. Effects of heme precursors on CYP1A2 and POR expression in the baculovirus/Spodoptera frugiperda system☆

    PubMed Central

    Lu, Huiyuan; Ma, Jun; Liu, Nian; Wang, Shoulin

    2010-01-01

    Objective CYP1A2 and NADPH-CYP450 oxidoreductase (POR) were expressed in the baculovirus/Spodoptera frugiperda (sf9) system. The aim of this study was to investigate the effects of heme precursors on the expression of CYP1A2 and POR. Methods The heme precursors [δ-Aminolaevulinic Acid (5-ALA), Fe3+ and hemin] were introduced into the system to evaluate their effects on the expression of CYP1A2, POR and their co-expression. All the proteins were identified using immunoblotting, CO-difference spectroscopy, or cytochrome c assay. Results In the present study, functional CYP1A2 and POR were successfully expressed in the baculovirus/sf9 system, and both of them showed high activities. Co-addition of 5-ALA and Fe3+ significantly improved expression of CYP1A2 by about 50% compared with the addition of 5-ALA, Fe3+ or hemin alone. Either co-addition of 5-ALA and Fe3+ or addition of 5-ALA or Fe3+ alone improved the POR expression level 2 fold and its activity 7-10 fold compared with control (no addition). However, unlike CYP1A2, there was no difference between the co-addition and addition of these heme precursors alone. Different ratios of BvCYP1A2 to BvPOR also affected the co-expression of CYP1A2 and POR, with a 3:1 ratio of BvCYP1A2 / BvPOR significantly increasing their co-expression. Surprisingly, the addition of 0.1 mM 5-ALA or Fe3+ alone, but not their co-addition, could significantly improve the CYP1A2 and POR co-expression (P < 0.05). Conclusion 5-ALA and Fe3+ increased the expression of CYP1A2 and POR in a baculovirus/sf9 system, but the pattern of their expression was different between their expression alone and co-expression. PMID:23554636

  14. Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter.

    PubMed

    Higgins, A M; Banik, B L; Brown, J L

    2015-02-01

    Bone grafting procedures in the United States rely heavily upon autografts and allografts, which are donor-dependent, cause donor site pain, and can transmit disease. Synthetic bone grafts can reduce these risks; however, synthetics lack the bone differentiating (osteoinductive) abilities of auto- and allografts. Achieving innate osteoinductive properties of synthetics through surface modifications is currently under investigation. This study focuses on nanofibers, with emphasis on how fiber diameter and the potential curvature sensor POR1 affect the activation of the signaling molecules Rac1 and Arf1, and leading to expression of alkaline phosphatase (ALP), an osteoinductive marker. Diameters of 0.1, 0.3, and 1.0 μm were compared against a flat control. The highest level of Rac1 activation was achieved on the smallest fibers (0.1 μm), a trend that was lost in POR1 knockdowns. This supports the hypothesis that on small nanofibers, POR1 favorably binds to highly curved cell membranes, which allows Rac1 to subsequently dissociate and activate. When the curvature is insufficient to bind POR1, POR1 binds to inactive Rac1 and competitively inhibits its activation. Arf1 activation followed an opposite trend, with the largest nanofibers exhibiting the highest activity. This trend reinforces the known interaction between Rac1 and Arf1 through the GIT-PIX complex, an Arf1 GAP and Rac1 GEF, respectively. Large, (1.0 μm), nanofibers demonstrated the highest ALP activity, indicating that ALP expression is inversely dependent on Rac1 activation. Knockdown of POR1 resulted in increased ALP activity across the substrates but without regard to the curvature sensing trend seen previously. Thus, POR1 senses curvature and increases Rac1 activity, which negatively regulates bone differentiation. PMID:25539497

  15. Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase (POR)

    PubMed Central

    Agrawal, Vishal; Choi, Ji Ha; Giacomini, Kathleen M.; Miller, Walter L.

    2010-01-01

    Objectives CYP3A4 receives electrons from P450 oxidoreductase (POR) to metabolize about 50% of clinically used drugs. There is substantial inter-individual variation in CYP3A4 catalytic activity that is not explained by CYP3A4 genetic variants. CYP3A4 is flexible and distensible, permitting it to accommodate substrates varying in shape and size. To elucidate mechanisms of variability in CYP3A4 catalysis, we examined the effects of genetic variants of POR, and explored the possibility that substrate-induced conformational changes in CYP3A4 differentially affect the ability of POR variants to support catalysis. Methods We expressed human CYP3A4 and four POR variants (Q153R, A287P, R457H, A503V) in bacteria, reconstituted them in vitro and measured the Michaelis constant and maximum velocity with testosterone, midazolam, quinidine and erythromycin as substrates. Results POR A287P and R457H had low activity with all substrates; Q153R had 76–94% of wild type (WT) activity with midazolam and erythromycin, but 129–150% activity with testosterone and quinidine. The A503V polymorphism reduced CYP3A4 activity to 61–77% of wild type with testosterone and midazolam, but had nearly wild type activity with quinidine and erythromycin. Conclusion POR variants affect CYP3A4 activities. The impact of a POR variant on catalysis by CYP3A4 is substrate-specific, probably due to substrate-induced conformational changes in CYP3A4. PMID:20697309

  16. Fabrication of por-Si/SnO{sub x} nanocomposite layers for gas microsensors and nanosensors

    SciTech Connect

    Bolotov, V. V. Korusenko, P. M.; Nesov, S. N.; Povoroznyuk, S. N.; Roslikov, V. E.; Kurdyukova, E. A.; Sten'kin, Yu. A.; Shelyagin, R. V.; Knyazev, E. V.; Kan, V. E.; Ponomareva, I. V.

    2011-05-15

    Two-phase nanocomposite layers based on porous silicon and nonstoichiometric tin oxide were fabricated by various methods. The structure, as well as elemental and phase composition, of the obtained nanocomposites were studied using transmission and scanning electron microscopy, Raman spectroscopy, Auger electron spectroscopy, and X-ray photoelectron spectroscopy. The results obtained confirm the formation of nanocomposite layers with a thickness as large as 2 {mu}m thick and SnO{sub x} stoichiometry coefficients x = 1.0-2.0. Significant tin diffusion into the porous silicon matrix with D{sub eff} Almost-Equal-To 10{sup -14} cm{sup 2} s{sup -1} was observed upon annealing at 770 K. Test sensor structures based on por-Si/SnO{sub x} nanocomposite layers grown by magnetron deposition showed fairly high stability of properties and sensitivity to NO{sub 2}.

  17. Recovery of naphthalene during evaporative concentration. [Tenax; XAD-2; POR-Q, XE-340

    SciTech Connect

    Higgins, C.E.; Guerin, M.R.

    1980-10-01

    The analysis of trace organics usually requires concentrating organic extracts to small volumes prior to instrumental analysis. The use of a concentration apparatus employing a nitrogen blanket and reduced pressure is desirable because the inert atmosphere and low temperature help to ensure stable composition. Unfortunately, diaromatic compounds such as the naphthalenes and biphenyls are frequently almost completely lost during the concentration step. Even under carefully controlled conditions only 26 +- 11% of the naphthalene is recovered. By placing a sorbent either in or downstream of the evaporation concentration flask, recovery of diaromatic compounds can be improved significantly. In this investigation, the following sorbents, Tenax, XAD-2, POR-Q, and XE-340 were tested. Recoveries with and without the use of sorbents, effects of solute concentration, purge time after solvent removal, and type of solvent used are reported here.

  18. Using the PORS Problems to Examine Evolutionary Optimization of Multiscale Systems

    SciTech Connect

    Reinhart, Zachary; Molian, Vaelan; Bryden, Kenneth

    2013-01-01

    Nearly all systems of practical interest are composed of parts assembled across multiple scales. For example, an agrodynamic system is composed of flora and fauna on one scale; soil types, slope, and water runoff on another scale; and management practice and yield on another scale. Or consider an advanced coal-fired power plant: combustion and pollutant formation occurs on one scale, the plant components on another scale, and the overall performance of the power system is measured on another. In spite of this, there are few practical tools for the optimization of multiscale systems. This paper examines multiscale optimization of systems composed of discrete elements using the plus-one-recall-store (PORS) problem as a test case or study problem for multiscale systems. From this study, it is found that by recognizing the constraints and patterns present in discrete multiscale systems, the solution time can be significantly reduced and much more complex problems can be optimized.

  19. Pedagogical Research at the UK OU.

    ERIC Educational Resources Information Center

    Chambers, Ellie

    This lecture describes the organization and kinds of pedagogical research undertaken in the United Kingdom Open University and, through a case study of educational research in the recently introduced Arts Foundation Course (A102), to show how one type of research can contribute to course organization and development. The Institute of Educational…

  20. Display of a PorA peptide from Neisseria meningitidis on the bacteriophage T4 capsid surface.

    PubMed Central

    Jiang, J; Abu-Shilbayeh, L; Rao, V B

    1997-01-01

    The exterior of bacteriophage T4 capsid is coated with two outer capsid proteins, Hoc (highly antigenic outer capsid protein; molecular mass, 40 kDa) and Soc (small outer capsid protein; molecular mass, 9 kDa), at symmetrical positions on the icosahedron (160 copies of Hoc and 960 copies of Soc per capsid particle). Both these proteins are nonessential for phage infectivity and viability and assemble onto the capsid surface after completion of capsid assembly. We developed a phage display system which allowed in-frame fusions of foreign DNA at a unique cloning site in the 5' end of hoc or soc. A DNA fragment corresponding to the 36-amino-acid PorA peptide from Neisseria meningitidis was cloned into the display vectors to generate fusions at the N terminus of Hoc or Soc. The PorA-Hoc and PorA-Soc fusion proteins retained the ability to bind to the capsid surface, and the bound peptide was displayed in an accessible form as shown by its reactivity with specific monoclonal antibodies in an enzyme-linked immunosorbent assay. By employing T4 genetic strategies, we show that more than one subtype-specific PorA peptide can be displayed on the capsid surface and that the peptide can also be displayed on a DNA-free empty capsid. Both the PorA-Hoc and PorA-Soc recombinant phages are highly immunogenic in mice and elicit strong antipeptide antibody titers even with a weak adjuvant such as Alhydrogel or no adjuvant at all. The data suggest that the phage T4 hoc-soc system is an attractive system for display of peptides on an icosahedral capsid surface and may emerge as a powerful system for construction of the next generation multicomponent vaccines. PMID:9353063

  1. Assessment of the current and future water balance of the Ouémé catchment (Benin) for an integrated water resource management by using the WEAP water planning model

    NASA Astrophysics Data System (ADS)

    Giertz, Simone; Diekkrüger, Bernd; Höllermann, Britta

    2010-05-01

    Today, fresh water has already become a critically scarce resource in many regions of the world. In many developing countries insufficient water supply infrastructure aggravates this problem. With the ongoing global change and population growth water security will become one of the major problems in the 21st century. Regarding the annual water balance the West African Country Benin is not suffering from physical water scarcity. Nevertheless, investigations show that water scarcity occurs at the local scale, especially at the end of the dry season. This is caused by reduced water availability in this period and particularly by the inadequate water supply infrastructure. Facing the impacts of climate and socio-economic change, an assessment of the national water resources is an important step to assure a sustainable water resource management and to satisfy the raising water demand of Benin in the future. In the presented study the WEAP water planning model was used to analyse the current and future water balance of Benin's largest catchment Ouémé. To take into account the possible impacts of climate and socio-economic change, two IPCC scenarios (A1B and B1) and three socio-economic scenarios were simulated for the time period 2002-2025. The results show that the pressure on Benin's water resources will increase, due to population growth and changing socio-economic conditions. This leads to a greater competition for surface water especially during the dry season. Improving the access to groundwater is an alternative; however, financial and institutional constraints hinder such a development. Furthermore, declining catchment inflows and groundwater recharge aggravate the situation and require an adapted groundwater management. Beside the scenario results the presentation will also examine the uncertainties of the modelling process with WEAP. Furthermore, the suitability of the model in supporting a sustainable and integrated water resources management in developing

  2. Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.

    PubMed

    Ribes, Vanessa; Otto, Diana M E; Dickmann, Leslie; Schmidt, Katy; Schuhbaur, Brigitte; Henderson, Colin; Blomhoff, Rune; Wolf, C Roland; Tickle, Cheryll; Dollé, Pascal

    2007-03-01

    Cytochrome P450 oxidoreductase (POR) acts as an electron donor for all cytochrome P450 enzymes. Knockout mouse Por(-/-) mutants, which are early embryonic (E9.5) lethal, have been found to have overall elevated retinoic acid (RA) levels, leading to the idea that POR early developmental function is mainly linked to the activity of the CYP26 RA-metabolizing enzymes (Otto et al., Mol. Cell. Biol. 23, 6103-6116). By crossing Por mutants with a RA-reporter lacZ transgene, we show that Por(-/-) embryos exhibit both elevated and ectopic RA signaling activity e.g. in cephalic and caudal tissues. Two strategies were used to functionally demonstrate that decreasing retinoid levels can reverse Por(-/-) phenotypic defects, (i) by culturing Por(-/-) embryos in defined serum-free medium, and (ii) by generating compound mutants defective in RA synthesis due to haploinsufficiency of the retinaldehyde dehydrogenase 2 (Raldh2) gene. Both approaches clearly improved the Por(-/-) early phenotype, the latter allowing mutants to be recovered up until E13.5. Abnormal brain patterning, with posteriorization of hindbrain cell fates and defective mid- and forebrain development and vascular defects were rescued in E9.5 Por(-/-) embryos. E13.5 Por(-/-); Raldh2(+/-) embryos exhibited abdominal/caudal and limb defects that strikingly phenocopy those of Cyp26a1(-/-) and Cyp26b1(-/-) mutants, respectively. Por(-/-); Raldh2(+/-) limb buds were truncated and proximalized and the anterior-posterior patterning system was not established. Thus, POR function is indispensable for the proper regulation of RA levels and tissue distribution not only during early embryonic development but also in later morphogenesis and molecular patterning of the brain, abdominal/caudal region and limbs. PMID:17126317

  3. Global Microlending in Education Reform: Enseñá Por Argentina and the Neoliberalization of the Grassroots

    ERIC Educational Resources Information Center

    Friedrich, Daniel S.

    2010-01-01

    This article examines the workings and underlying assumptions behind Enseñá por Argentina (Teach for Argentina), one specific program that takes part in the larger and expanding network of Teach for All, by thinking about the ways in which a global push for redefining teaching and teacher education encounters local characteristics and histories,…

  4. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    PubMed

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972. PMID:21250499

  5. Functional POR A503V is associated with the risk of bladder cancer in a Chinese population

    PubMed Central

    Xiao, Xue; Ma, Gaoxiang; Li, Shushu; Wang, Meilin; Liu, Nian; Ma, Lan; Zhang, Zhan; Chu, Haiyan; Zhang, Zhengdong; Wang, Shou-Lin

    2015-01-01

    Human cytochrome P450 oxidoreductase (POR) plays important roles in the metabolism of exogenous carcinogens and endogenous sterol hormones. However, few studies have explored the association between POR variants and the risk of bladder cancer. In this study, we first sequenced all 16 POR exons among 50 randomly selected controls, and found three variants, rs1135612, rs1057868 (A503V) and rs2228104, which were then assessed the relation to risk of bladder cancer in a case-control study of 1,050 bladder cancer cases and 1,404 cancer-free controls in a Chinese population. People with A503V TT genotype have a decreased risk of bladder cancer in a recessive model (TT vs. CC/CT, OR = 0.73, 95% CI = 0.57–0.93), which was more pronounced among elderly male, non-smoking, subjects. Especially, A503V TT genotype showed a protective effect in the invasive tumor stage. Functional analysis revealed that A503V activity decreased in cytochrome c reduction (50.5 units/mg vs. 135.4 units/mg), mitomycin C clearance (38.3% vs. 96.8%), and mitomycin C-induced colony formation (78.0 vs 34.3 colonies per dish). The results suggested that POR A503V might decrease the risk of bladder cancer by reducing its metabolic activity, and should be a potential biomarker for predicting the susceptibility to human bladder cancer. PMID:26123203

  6. Sédimentologie et évidence d'une tectonique Tardi-Hercynienne d'âge Permien Inférieur dans le bassin des Ida Ou Ziki; sud-ouest du massif ancien du Haut-Atlas (region d'Argana, Maroc)

    NASA Astrophysics Data System (ADS)

    Saber, Hafid

    1994-08-01

    The Permian Ida Ou Ziki sequence, approximately 1200 m thick, is detrital in origin. Sedimentological data clearly indicate a fluviatile environment. The palaeocurrents show that during the infilling of the basin, the detrital source region was constantly to the north. From a study of the clay minerals, based on the dominance of illite and not inconsiderable proportions of kaolinite and chlorite, a wet warm and humid climate is indicated. The Ida Ou Ziki basin has been affected by synsedimentary post-Hercynian movement. It suggests an important subsidence phase controlled by the Tirkou fault, and by disturbances affecting the lower part of the succession. Listric faults and small-scale grabens associated with slumping gave an extensional direction approximately to the NW-SE. As part of this extensional phase, the basin was subjected to a post-depositional pre-Upper Triassic northerly regional compression

  7. Inversor Resonante de Tres Elementos L-LC con Caracteristica Cortocircuitable para Aplicaciones de Calentamiento por Induccion

    NASA Astrophysics Data System (ADS)

    Espi Huerta, Jose Miguel

    Los generadores de calentamiento por induccion son puentes inversores con carga resonante, cuya mision es basicamente crear una corriente sinusoidal de gran amplitud sobre la "bobina de caldeo", que forma parte del tanque resonante. En el interior de esta bobina se introduce la pieza que se desea calentar. EI campo magnetico creado induce corrientes superficiales (corrientes de Foucault) sobre la pieza, que producen su calentamiento. Los tanques resonantes (tambien llamados osciladores) utilizados en la actualidad son el resonante serie y el resonante paralelo. Aunque ya desde hace algun tiempo se vienen construyendo generadores de alta potencia basados en estos dos osciladores, el exito nunca ha. sido completo en ninguno de los dos casos. Tal y como se explica en la introduccion de esta memoria, los puentes inversores utilizados deben operar sobre una carga inductiva (corriente retrasada) para evitar el fenomeno de la recuperacion inversa de sus diodos y la consiguiente ruptura de los transistores. De la restriccion topologica anterior se deduce que el generador paralelo debe conmutar a frecuencias inferiores a la resonancia, y el serie a frecuencias superiores. A esta restriccion topologica hay que unir otra que es exclusiva del calentamiento por induccion: La corriente por la bobina de caldeo debe ser sinusoidal. De no ser asi, resultaria imposible disponer toda la potencia de calentamiento sobre la pieza en el espesor requerido por la aplicacion. Como consecuencia, los inversores no pueden operar por debajo de la frecuencia de resonancia del oscilador, pues en ese caso se amplifican los armonicos de orden superior de la tension/corriente de entrada situados sobre la resonancia, con la consiguiente distorsion de la corriente de salida. La conjuncion de las dos restricciones anteriores obligan al inversor paralelo a funcionar a la frecuencia de resonancia del oscilador. Esto imposibilita un control por variacion de frecuencia, regulandose la potencia desde la

  8. Encefalitis por anticuerpos contra el receptor de NMDA: experiencia con seis pacientes pediátricos. Potencial eficacia del metotrexato

    PubMed Central

    Bravo-Oro, Antonio; Abud-Mendoza, Carlos; Quezada-Corona, Arturo; Dalmau, Josep; Campos-Guevara, Verónica

    2016-01-01

    Introducción La encefalitis por anticuerpos contra el receptor de N-metil-D-aspartato (NMDA) es una entidad cada vez más diagnosticada en edad pediátrica. A diferencia de los adultos, en muchos casos no se asocia a tumores y las manifestaciones iniciales en niños más frecuentes son crisis convulsivas y trastornos del movimiento, mientras que en los adultos predominan las alteraciones psiquiátricas. Casos clínicos Presentamos seis casos pediátricos confirmados con anticuerpos contra la subunidad NR1 del receptor de NMDA en suero y líquido cefalorraquídeo. Cinco de los casos comenzaron con crisis convulsivas como manifestación clínica inicial antes de desarrollar el cuadro clásico de esta entidad. En todos los casos se utilizaron esteroides como primera línea de tratamiento, con los que sólo se observó control de las manifestaciones en uno, por lo que el resto de los pacientes requirió inmunomoduladores de segunda línea. Todos los pacientes recibieron metotrexato como tratamiento inmunomodulador para evitar recaídas y la evolución fue a la mejoría en todos ellos. Conclusiones En nuestra serie de pacientes con encefalitis por anticuerpos contra el receptor de NMDA, ninguno se asoció a tumores. Todos los casos recibieron metotrexato por lo menos durante un año, no observamos eventos adversos clínicos ni por laboratorio, ni hubo secuelas neurológicas ni recaídas durante el tratamiento. Aunque es una serie pequeña y es deseable incrementar el número y tiempo de evolución, consideramos el metotrexato una excelente alternativa como tratamiento inmunomodulador para esta patología. PMID:24150952

  9. Epidémiologie et prise en charge des infections du per-partum à la maternité du centre hospitalier départemental de l'Ouémé-Plateau au Bénin

    PubMed Central

    Saizonou, Jacques; Ouédraogo, Laurent; Paraiso, Moussiliou Noël; Ayélo, Paul; Kpozèhouen, Alphonse; Daraté, René; Traoré, Esther

    2014-01-01

    Introduction La présente étude avait pour objectif de mesurer l'ampleur des infections du per-partum à la maternité du Centre Hospitalier Départemental de l'Ouémé-Plateau d'analyser les conditions de survenue et de prise en charge dans la perspective de l'amélioration des soins et services maternels et néonataux. Méthodes Une étude descriptive et analytique a été conduite de Août 2009 à Février 2010 et a impliqué 110 mères victimes d'infections du per-partum; elles ont été soumises à un questionnaire durant tout leur séjour hospitalier; des observations des pratiques de prise en charge des prestataires de soins ont été menées et des registres et autres supports de données sanitaires ont été exploités. L'analyse des données a été effectuée à l'aide du logiciel Epi Info 6.4 dans sa version française. Résultats L'incidence des infections du per-partum était de 5,9 pour 100 accouchements (110/ 1875); les types d'infections les plus incriminés étaient les endométrites (27,3%), les chorioamniotites (18,2%), les infections du site opératoire (12,7%) et les infections urinaires (2,7%). Les examens cliniques ont été relativement acceptables. En revanche, les examens biologiques ont été très insuffisants expliquant l'imprécision importante au niveau des diagnostics. L'antibiothérapie a été instaurée systématiquement. Le taux de mortinaissance était de 25,6% et les enfants de petit poids représentaient 23,2%. Conclusion L'incidence des infections du per-partum dans la présente étude était assez élevée. Des efforts de préventions et de dépistage de ces infections sont nécessaire afin d'améliorer la qualité des soins PMID:25120854

  10. Les manifestations oculaires au cours de la pré-éclampsie sévère ou l’éclampsie au Centre Hospitalier Universitaire Sourô Sanou de Bobo Dioulasso

    PubMed Central

    Diallo, Jean Wenceslas; Méda, Nonfounikoun; Ahnoux-Zabsonré, Ahgbatouhabéba; Ouattara, Souleymane; Yanogo, Armande; Tougouma, Somnoma Jean Baptiste; Somé, Der; Sanou, Jérôme; Dolo, Mariam

    2015-01-01

    La pré-éclampsie sévère est un problème de santé publique. L'atteinte oculaire est une de ses nombreuses complications. Le but de notre travail était de décrire les atteintes oculaires chez les patientes présentant une pré-éclampsie et/ou éclampsie afin de contribuer à leur meilleure prise en charge. Il s'est agi d'une étude transversale descriptive à collecte prospective allant du 1er novembre 2013 au 31 juillet 2014, chez les patientes ayant souffert de pré-éclampsie sévère/éclampsie. Nous avons inclus 127 patientes dans notre étude. La moyenne d’âge des patientes de notre étude était de 26,37 ans (ET= 6,8 ans), avec des extrêmes de 15 et 40 ans. Les tranches d’âge les plus représentées étaient celles de 26 à 30 ans avec 29,1% des cas et celle des 15 à 20 ans avec 25,2%. Le diagnostic de pré-éclampsie sévère a été retenu dans 69,3% des cas. Les primigestes représentaient 40,9% de la population. Les troubles visuels à type de phosphènes ont été observés chez 33,1% des patientes. Nous avons noté un courant granulaire conjonctival dans 41,7%, des lésions du segment postérieur chez 32,3% des patientes. Ces résultats ont été discutés par rapport à la littérature, et nous notons plus de cas d'atteinte rétinienne. Nous n'avons pas trouvé de lien statistiquement significatif entre la tension artérielle à l'admission et le stade de la rétinopathie hypertensive. Les complications oculaires de la pré-éclampsie sévère sont très fréquentes et souvent ignorées. Les atteintes rétiniennes sont fréquentes mais de bon pronostic. PMID:26405485

  11. Patients diabétiques de type 2 hypertendus: préfèrent-ils traiter le diabète ou l'hypertension artérielle?

    PubMed Central

    Aassri, Hind El; El Mghari, Ghizlane; El Ansari, Nawal

    2014-01-01

    Les diabétologues sont confrontés à des diabétiques le plus souvent hypertendus et polypathologiques, les rendant peu observants des différentes thérapeutiques prescrites. Le but de notre étude est d’évaluer l'observance au traitement chez les patients diabétiques hypertendus. Il s'agit d'une étude descriptive prospective transversale. La population est faite de patients diabétiques de type 2 hypertendus vus aux urgences, à la consultation ou hospitalisés au service d'Endocrinologie. L’échantillon est non probabiliste. La population est faite de 61 patients, d'un âge moyen de 48,9 ans avec une hypertension (HTA) de type systolique dans 59%, diastolique dans 16% et systolo-diastolique dans 25% des cas. Les patients sont équilibrés sur le plan glycémique dans 65% des cas, alors que l’équilibre tensionnel n'est atteint que dans 41% des cas. En ce qui concerne l'observance thérapeutique, 24% des patients sont observant totalement au traitement prescrit, 33% ne sont pas observant au traitement et 43% ont une observance partielle au traitement dont 73.68% préfèrent le traitement destiné au diabète et 26,32% prennent le traitement anti hypertenseur. Les facteurs altérant l'observance au traitement médicamenteux sont un surcoût du traitement un nombre élevé de médicaments prescrits, un nombre important de prises quotidiennes de médicaments, une intolérance au traitement et une mauvaise information du patient sur la justification du traitement. Enfin, les patients diabétiques hypertendus sont classés comme patients à haut risque cardiovasculaire ce qui impose l'application de stratégies thérapeutiques parfois lourdes. Cette polymédication entrave la qualité de l'observance thérapeutique des patients ayant une pathologie chronique dont la compliance au traitement constitue la pierre angulaire de la prise en charge, et ce pour plusieurs raisons en particulier d'ordre économique. PMID:25396019

  12. Prevalencia y tamizaje del Trastorno por Déficit de Atención con Hiperactividad en Costa Rica

    PubMed Central

    Weiss, Nicholas T.; Schuler, Jovita; Monge, Silvia; McGough, James J.; Chavira, Denise; Bagnarello, Monica; Herrera, Luis Diego; Mathews, Carol A.

    2015-01-01

    Resumen La investigación tuvo como propósito estimar la prevalencia del Trastorno por Déficit de Atención con Hiperactividad (TDAH) en Costa Rica y determinar si la versión en español del cuestionario Swanson Nolan and Pelham Scale IV (SNAP-IV) es un instrumento de tamizaje útil en una población de niños y niñas escolares costarricenses. El instrumento fue entregado a padres y maestros de 425 niños entre 5 y 13 años de edad (promedio = 8.8). Todos fueron evaluados con el instrumento Swanson, Kotkin, Agler, M-Flynn and Pelham Scale (SKAMP). Su diagnóstico fue confirmado con una entrevista clínica. La sensibilidad y la especificidad del SNAP-IV fueron evaluadas como predictores de criterios de diagnóstico según el DSM-IV. La prevalencia puntual en la muestra del TDAH fue del 5%. El tamizaje más preciso lo hizo el SNAP-IV completado por el maestro en un corte de 20%, con una sensibilidad de 96% y una especificidad de un 82%. La sensibilidad de los instrumentos completados por los padres fue más baja que aquella de los maestros. El SNAP-IV completado por las maestras con un corte aislando el 20% de los mayores puntajes categorizó correctamente a un 87% de los sujetos. PMID:22432094

  13. Ouateres ou veces? Emprunt ou etymologie? ("Ouateres" or "Veces"? Borrowing or Etymology?).

    ERIC Educational Resources Information Center

    Calvet, Louis-Jean

    1989-01-01

    The variety of terms used by different cultures for bathroom facilities not only illustrates the problems language poses for travelers but also opens a discussion of the distinction between linguistic borrowing and etymology. (MSE)

  14. Targeting of Neisserial PorB to the mitochondrial outer membrane: an insight on the evolution of β-barrel protein assembly machines.

    PubMed

    Jiang, Jhih-Hang; Davies, John K; Lithgow, Trevor; Strugnell, Richard A; Gabriel, Kipros

    2011-11-01

    Mitochondria originated from Gram-negative bacteria through endosymbiosis. In modern day mitochondria, the Sorting and Assembly Machinery (SAM) is responsible for eukaryotic β-barrel protein assembly in the mitochondrial outer membrane. The SAM is the functional equivalent of the β-barrel assembly machinery found in the outer membrane of Gram-negative bacteria. In this study we examined the import pathway of a pathogenic bacterial protein, PorB, which is targeted from pathogenic Neisseria to the host mitochondria. We have developed a new method for measurement of PorB assembly into mitochondria that relies on the mobility shift exhibited by bacterial β-barrel proteins once folded and separated under semi-native electrophoretic conditions. We show that PorB is targeted to the outer mitochondrial membrane with a dependence on the intermembrane space shuttling chaperones and the core component of the SAM, Sam50, which is a functional homologue of BamA that is required for PorB assembly in bacteria. The peripheral subunits of the SAM, Sam35 and Sam37, which are essential for eukaryotic β-barrel protein assembly but do not have distinguishable functional homologues in bacteria, are not required for PorB assembly in eukaryotes. This shows that PorB uses an evolutionary conserved 'bacterial like' mechanism to infiltrate the host mitochondrial outer membrane. PMID:22032638

  15. Epitope specificity of murine and human bactericidal antibodies against PorA P1.7,16 induced with experimental meningococcal group B vaccines.

    PubMed

    Rouppe van der Voort, E M; Kuipers, B; Brugghe, H F; van Unen, L M; Timmermans, H A; Hoogerhout, P; Poolman, J T

    1997-03-01

    Synthetic peptides derived from the predicted loops 1 and 4 of meningococcal PorA, sero-subtype P1.7,16, were used to study the epitope specificity of murine and human PorA P1.7,16 bactericidal antibodies. The predicted loops 1 and 4 are surface exposed and carry in their apices the sero-subtype epitopes P1.7 (loop 1) or P1.16 (loop 4), respectively. Peptides were synthesized as mono- and multimeric peptides. Murine monoclonal and polyclonal antibodies were induced with meningococcal whole cell preparations. Polyclonal antibodies were evoked in volunteers after one immunization with 50 micrograms or 100 micrograms protein of a hexavalent meningococcal PorA vesicle vaccine. The induction of PorA antibodies was determined in ELISA using purified PorA P1.7,16. The epitope specificity of anti-PorA antibodies for both murine and human antibodies could be demonstrated by direct peptide ELISA using overlapping multimeric peptides almost spanning the entire loops 1 or 4 of the protein. The capacity of peptides to inhibit the bactericidal activity of murine and human antibodies was investigated using meningococcal strain H44/76 (B:15:P1.7,16) as a target strain. Bactericidal activities could be inhibited with both monomeric and multimeric peptides derived from epitopes P1.7 and P1.16. PMID:9093834

  16. Análise dos Conceitos Astronômicos Apresentados por Professores de Algumas Escolas Estaduais Brasileiras

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; Gonzaga, Edson Pereira

    2011-12-01

    A razão para o desenvolvimento deste trabalho baseia-se no fato de que muitos professores da Educação Básica (EB) não lidam com conceitos relacionados à astronomia, e quando o fazem eles simplesmente seguem livros didáticos que podem conter erros conceituais. Como é de conhecimento geral a astronomia é um dos conteúdos a serem ensinados na EB fazendo parte dos Parâmetros Curriculares Nacionais e das Propostas Curriculares do Estado de São Paulo, mas é um fato, que vários pesquisadores apontam, a existência de muitos problemas no ensino da astronomia. Com o propósito de minimizar algumas dessas deficiências foi realizado um trabalho de pesquisa com a utilização de questionários pré e pós pesquisa, para tanto foi desenvolvido um Curso de Extensão Universitária para professores da Diretoria de Ensino Regional (DE) que abrange Mauá, Ribeirão Pires e Rio Grande da Serra (no Estado de São Paulo) com os seguintes objetivos: levantar concepções alternativas; subsidiar os professores por meio de palestras, debates e workshops, e verificar o sucesso da aprendizagem após o curso, adotando-se como referência, para a análise dos resultados, os dicionários de Língua Portuguesa (FERREIRA, 2004) e Enciclopédico de Astronomia e Astronáutica (MOURĀO, 1995). Portanto, dezesseis questões foram aplicadas antes e após o curso, assim pode-se verificar após a pesquisa que 100,0% dos professores sabiam os nomes das fases da Lua, 97,0% entenderam que o Sistema Solar é composto por oito planetas, 78,1% foram capazes de explicar como ocorre um eclipse lunar, um eclipse solar e um solstício, 72,7% sabiam como explicar a ocorrência das estações do ano; 64,5% explicaram corretamente a ocorrência do equinócio, 89,7% foram capazes de definir adequadamente o termo cometa; 63,6% definiram asteróide, 54,5% meteoro, 58,1% galáxia, e 42,4% planeta. Os resultados obtidos indicam uma aprendizagem significativa por parte dos participantes.

  17. Rupture bilatérale des tendons rotuliens chez un sujet jeune sans notion de maladies systémiques ou de traitement par les corticostéroïdes: à propos d'un cas et revue de la literature

    PubMed Central

    Chagou, Aniss; Rhanim, Abdelkarim; Berrady, Mohammed Ali; Lamrani, Moulay Omar; Oudghiri, Mohammed; Berrada, Mohammed Saleh; El Yaacoubi, Moradh

    2014-01-01

    Les lésions du tendon rotulien sont moins communes que celles du tendon quadricipital. Les lésions bilatérales sont encore plus rares et sont souvent associées à une notion de tendinopathie, d'injection de corticoïdes ou de maladies systémiques tels que le lupus érythémateux, l'ostéomalacie ou l'insuffisance rénale chronique. Nous rapportons le cas d'un patient de 26 ans victime d'une rupture bilatérale du tendon rotulien suite à une réception de saut. Le patient n'avait pas d'antécédents de tendinopathie ni de maladies systémiques. Le diagnostic a été suspecté devant une position anormalement haute des deux rotules avec une impossibilité d'extension active des deux jambes. L’échographie a confirmé le diagnostic. Le patient a été traité par la technique de laçage selon Judet protégée par un cadrage. La rupture bilatérale du tendon rotulien est rare. La plupart des patients rapportent une notion de maladie systémique ou un antécédents de chirurgie du genou. Nous rapportons le cas d'une lésion rare dans la littérature, une rupture bilatérale des tendons rotuliens sans notions de maladies auto-immunes ni de traitement avec des corticostéroïdes. Les lésions bilatérales présentent certaines particularités diagnostiques et thérapeutiques. En effet l'objectivation d'une rotule haute peut être rendu difficile par un aspect controlatéral semblable. Concernant le volet thérapeutique, deux difficultés sont à noter la première réside dans l'absence de référence comparative pour la hauteur patellaire. La deuxième difficulté est l'obligation de différer l'appui à 45 jours. Ce qui est contraignant pour le patient. La technique de laçage décrite par judet couplée à un cadrage provisoire protégeant la suture nous a donné des résultats satisfaisants. PMID:25667711

  18. Immunogenicity and reactogenicity in UK infants of a novel meningococcal vesicle vaccine containing multiple class 1 (PorA) outer membrane proteins.

    PubMed

    Cartwright, K; Morris, R; Rümke, H; Fox, A; Borrow, R; Begg, N; Richmond, P; Poolman, J

    1999-06-01

    The development of effective vaccines against serogroup B meningococci is of great public health importance. We assessed a novel genetically engineered vaccine containing six meningococcal class 1 (PorA) outer membrane proteins representing 80% of prevalent strains in the UK. 103 infants were given the meningococcal vaccine at ages 2, 3 and 4 months with routine infant immunisations, with a fourth dose at 12-18 months. The vaccine was well tolerated. Three doses evoked good immune responses to two of six meningococcal strains expressing PorA proteins contained in the vaccine. Following a fourth dose, larger bactericidal responses to all six strains were observed, suggesting that the initial course had primed memory lymphocytes and revaccination stimulated a booster response. This hexavalent PorA meningococcal vaccine was safe and evoked encouraging immune responses in infants. Vaccines of this type warrant further development and evaluation. PMID:10418910

  19. The Bi-Digital O-Ring Test used in the successful diagnosis & treatment (with antibiotic, anti-viral agents & oriental herbal medicine) of a patient suffering from pain & weakness of an upper extremity & Barré-Liéou syndrome appearing after whiplash injury. A case report.

    PubMed

    Ayuzawa, S; Yano, H; Enomoto, T; Kobayashi, H; Nose, T

    1997-01-01

    A patient with a whiplash injury suffering from prolonged symptoms, including pain and weakness of the right upper extremity and the symptoms of Barré-Liéou syndrome, was diagnosed and treated with the Bi-Digital O-Ring Test as a supplement to standard medical examinations. Radiological findings showed spondylotic canal stenosis with osteophytes and disc protrusions. The Bi-Digital O-Ring Test indicated a strong abnormal response around the right side of his neck and right shoulder, including the area of the vertebral artery and at acupuncture point GB 21, where positive resonant responses to Cytomegalovirus and Streptococcus faecalis were detected. Antibiotic and anti-viral agents, as well as Ku-Oketsu-Zai, a type of Oriental herbal medicine for overcoming blood stagnation or stasis, were administered according to the drug compatibility test using the Bi-Digital O-ring Test and the following clinical results were obtained. Infection at the site of the vertebral artery and the peri-arterial sympathetic nerve plexus was considered as a cause of the prolongation of the symptoms including Barré-Liéou syndrome, in this case. In addition we especially noted, in this clinical case, that the patient's impaired grasping force dramatically improved from 8 kg to 52 kg in a very short periods of time when the patient held suitable medicine selected with the Bi-Digital O-Ring Test drug compatibility test. We assume that the drug action was transferred electromagnetically, by which the pathological electromagnetic oscillations caused by trauma and following infections were scavenged. This effect might lead to an improvement in the coordination of the neuromuscular system. PMID:9494625

  20. Crystallization and preliminary X-ray analysis of the C-terminal fragment of PorM, a subunit of the Porphyromonas gingivalis type IX secretion system.

    PubMed

    Stathopulos, Julien; Cambillau, Christian; Cascales, Eric; Roussel, Alain; Leone, Philippe

    2015-01-01

    PorM is a membrane protein involved in the assembly of the type IX secretion system (T9SS) from Porphyromonas gingivalis, a major bacterial pathogen responsible for periodontal disease in humans. The periplasmic domain of PorM was overexpressed in Escherichia coli and purified. A fragment of the purified protein was obtained by limited proteolysis. Crystals of this fragment belonged to the tetragonal space group P4(3)2(1)2. Native and MAD data sets were recorded to 2.85 and 3.1 Å resolution, respectively, using synchrotron radiation. PMID:25615973

  1. "Estudio tribologico de aceros para moldes. Aplicacion al moldeo por inyeccion de polibutilentereftalato reforzado con fibra de vidrio"

    NASA Astrophysics Data System (ADS)

    Martinez Mateo, Isidoro Jose

    Mould materials for injection moulding of polymers and polymer-matrix composites represent a relevant industrial economic sector due to the large quantity of pieces and components processed. The material selection for mould manufacturing, its composition and heat treatment, the hardening procedures and machining and finishing processes determine the service performance and life of the mould. In the first part of the present study, the relationship between the hardness and microstructure and the wear resistance of mould steels from large blocks has been studied by pin-on-disc tests, studying the main wear mechanisms. In order to determine the surface damage on mould steels under real injection conditions, different commercial steels have been studied by measuring the variation of surface roughness with the number of injected pieces with different reinforcement percentages and different mould geometries, by using optical profilometry and scanning electron microscopy techniques. It was important to determine the variation of surface roughness of the moulded pieces with the number of injection operations. The materials used were polybutyleneterephthalate pure and reinforced with either 20% or 50% glass fibre. For the different mould designs, the evolution of the glass fibre orientation with injection flow has been determined by image analysis and related to roughness changes and surface damage, both of the composite parts and of the mould steel surface. Finally, the abrasion resistance of the composite parts has been studied by scratch tests as a function of the number of injected parts and of the scratch direction with respect to injection flow and glass fibre orientation. Los materiales para moldes de inyeccion de polimeros y materiales compuestos representan un sector economicamente muy relevante debido al gran aumento del numero de componentes fabricados a partir de materiales polimericos obtenidos mediante moldeo por inyeccion. La seleccion del material para la

  2. P(O)R2-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands

    PubMed Central

    Hu, Rong-Bin; Wang, Hong-Li; Zhang, Hong-Yu; Zhang, Heng; Ma, Yan-Na

    2014-01-01

    Summary Chiral phosphorus ligands have been widely used in transition metal-catalyzed asymmetric reactions. Herein, we report a new synthesis approach of chiral biaryls containing a phosphorus moiety using P(O)R2-directed Pd-catalyzed C–H activation; the functionalized products are produced with good enantioselectivity. PMID:25246966

  3. Adult Student Retention and Achievement with Language-Based Modular Materials. POR FIN: Program Organizing Related Family Instruction in the Neighborhood.

    ERIC Educational Resources Information Center

    Bexar County School Board, San Antonio, TX.

    The goal of the POR FIN research design was to develop a language-based curriculum emphasizing the audiolingual approach and integrating academic and social-functioning subject matter. The modular curriculum is designed so that each lesson is independent and complete in itself, and provides a high degree of motivation, retention, and achievement…

  4. Informe a la nación indica que los índices de muertes por cáncer siguen bajando

    Cancer.gov

    Los índices de mortalidad por todos los cánceres combinados para hombres, mujeres y niños siguieron bajando en Estados Unidos entre 2004 y 2008, según el Informe Anual a la Nación sobre el Estado del Cáncer de 1975 a 2008. El índice general de diagnóstico

  5. El proceso hacia la integracion de la equidad por genero al curriculo.(The Process of the Integration of Gender Equity in the Curriculum.)

    ERIC Educational Resources Information Center

    Rivera-Bermudez, Carmen D.

    "El Proyecto Colaborativo de Equidad por Genero en la Educacion," or the Collaborative Project for Gender Equity in Education, was undertaken in Puerto Rico between 1990 and 1992 to study how to facilitate the integration of gender equity themes in the curriculum through the direct action of participating teachers. A study examined the attitudes…

  6. Community-based education in nutrition and cancer: the Por La Vida Cuidándome curriculum.

    PubMed

    Navarro, A M; Rock, C L; McNicholas, L J; Senn, K L; Moreno, C

    2000-01-01

    The Por La Vida (PLV) intervention model relies on community lay health advisors trained to conduct education sessions among members of their existing social networks. PLV Cuidándome was funded by the NCI to develop, implement, and evaluate the PLV model with respect to nutrition and cancer prevention, as well as early detection of breast and cervical cancers. The target population is the Latino community, for which substantial barriers to health care access exist. This article presents the curriculum that guides the sessions and describes its development, which was based on semi-structured interviews with Latina lay-health community workers to explore relevant attitudes and behaviors. Also key to the process was the work of the educational materials committee, whose members offered community representation as well as expertise in nutritional sciences, educational technologies, and community-based health promotion interventions and research. The 12-session curriculum's goal was to increase both the variety and the quality of fruits and/or vegetables consumed. It included information about consumption of fiber and fat in the importance of balance between energy intake and physical activity. The program has been well received. An ongoing study examines how it enhances nutrition and cancer prevention. PMID:11019766

  7. Estimaciones de Prevalencia del VIH por Género y Grupo de Riesgo en Tijuana, México: 2006

    PubMed Central

    Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.

    2010-01-01

    OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas por el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824

  8. Study of the interaction mechanisms between absorbed NO{sub 2} and por-Si/SnO{sub x} nanocomposite layers

    SciTech Connect

    Bolotov, V. V.; Kan, V. E. Makushenko, R. K.; Biryukov, M. Yu.; Ivlev, K. E.; Roslikov, V. E.

    2013-10-15

    The interaction mechanisms between NO{sub 2} molecules and the surface of por-Si/SnO{sub x} nanocomposites obtained by magnetron deposition and chemical vapor deposition (CVD) are studied by infrared absorption spectroscopy and electron paramagnetic resonance methods. The observed increase in the free carrier concentration in the por-Si/SnO{sub x} nanocomposite layers is explained by a change in the charge state of P{sub b} centers due to the formation of neutral 'surface defect-adsorbed NO{sub 2} molecule' complexes with free carrier generation in the crystallite bulk. In the nanocomposite layers grown by the CVD method, the increase in the free hole concentration during NO{sub 2} adsorption is much less pronounced in comparison with the composite grown by magnetron deposition, which is caused by the competing interaction channel of NO{sub 2} molecules with electrically neutral P{sub b} centers.

  9. Los índices de mortalidad por cáncer de pulmón siguen en descenso y contribuyen a la continua reducc

    Cancer.gov

    El Informe Anual a la Nación sobre el Estado del Cáncer (1975 a 2010), mostró un descenso más acelerado que en años anteriores de los índices de mortalidad por cáncer de pulmón. También contiene una sección especial que destaca los efectos significativos

  10. La doctora Amelie Ramírez y la investigación de desigualdades de salud por cáncer en la comunidad la

    Cancer.gov

    La doctora Ramírez es la investigadora principal de Redes en Acción, un centro del programa de redes comunitarias subvencionado por el NCI que se propone reducir la incidencia del cáncer en la comunidad latina a través de una red nacional de grupos comunitarios, investigadores, agencias de salud gubernamentales y la población en general.

  11. Binding of Complement Factor H to PorB3 and NspA Enhances Resistance of Neisseria meningitidis to Anti-Factor H Binding Protein Bactericidal Activity

    PubMed Central

    Giuntini, Serena; Pajon, Rolando; Ram, Sanjay

    2015-01-01

    Among 25 serogroup B Neisseria meningitidis clinical isolates, we identified four (16%) with high factor H binding protein (FHbp) expression that were resistant to complement-mediated bactericidal activity of sera from mice immunized with recombinant FHbp vaccines. Two of the four isolates had evidence of human FH-dependent complement downregulation independent of FHbp. Since alternative complement pathway recruitment is critical for anti-FHbp bactericidal activity, we hypothesized that in these two isolates binding of FH to ligands other than FHbp contributes to anti-FHbp bactericidal resistance. Knocking out NspA, a known meningococcal FH ligand, converted both resistant isolates to anti-FHbp susceptible isolates. The addition of a nonbactericidal anti-NspA monoclonal antibody to the bactericidal reaction also increased anti-FHbp bactericidal activity. To identify a role for FH ligands other than NspA or FHbp in resistance, we created double NspA/FHbp knockout mutants. Mutants from both resistant isolates bound 10-fold more recombinant human FH domains 6 and 7 fused to Fc than double knockout mutants prepared from two sensitive meningococcal isolates. In light of recent studies showing functional FH-PorB2 interactions, we hypothesized that PorB3 from the resistant isolates recruited FH. Allelic exchange of porB3 from a resistant isolate to a sensitive isolate increased resistance of the sensitive isolate to anti-FHbp bactericidal activity (and vice versa). Thus, some PorB3 variants functionally bind human FH, which in the presence of NspA enhances anti-FHbp resistance. Combining anti-NspA antibodies with anti-FHbp antibodies can overcome resistance. Meningococcal vaccines that target both NspA and FHbp are likely to confer greater protection than either antigen alone. PMID:25644002

  12. Corynebacterium jeikeium jk0268 Constitutes for the 40 Amino Acid Long PorACj, Which Forms a Homooligomeric and Anion-Selective Cell Wall Channel

    PubMed Central

    Norouzy, Amir; Schulz, Robert; Nau, Werner M.; Kleinekathöfer, Ulrich; Tauch, Andreas; Benz, Roland

    2013-01-01

    Corynebacterium jeikeium, a resident of human skin, is often associated with multidrug resistant nosocomial infections in immunodepressed patients. C. jeikeium K411 belongs to mycolic acid-containing actinomycetes, the mycolata and contains a channel-forming protein as judged from reconstitution experiments with artificial lipid bilayer experiments. The channel-forming protein was present in detergent treated cell walls and in extracts of whole cells using organic solvents. A gene coding for a 40 amino acid long polypeptide possibly responsible for the pore-forming activity was identified in the known genome of C. jeikeium by its similar chromosomal localization to known porH and porA genes of other Corynebacterium strains. The gene jk0268 was expressed in a porin deficient Corynebacterium glutamicum strain. For purification temporarily histidine-tailed or with a GST-tag at the N-terminus, the homogeneous protein caused channel-forming activity with an average conductance of 1.25 nS in 1M KCl identical to the channels formed by the detergent extracts. Zero-current membrane potential measurements of the voltage dependent channel implied selectivity for anions. This preference is according to single-channel analysis caused by some excess of cationic charges located in the channel lumen formed by oligomeric alpha-helical wheels. The channel has a suggested diameter of 1.4 nm as judged from the permeability of different sized hydrated anions using the Renkin correction factor. Surprisingly, the genome of C. jeikeium contained only one gene coding for a cell wall channel of the PorA/PorH type found in other Corynebacterium species. The possible evolutionary relationship between the heterooligomeric channels formed by certain Corynebacterium strains and the homooligomeric pore of C. jeikeium is discussed. PMID:24116064

  13. Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant PorA Protein: A Comparison in Mice

    PubMed Central

    Mehta, Ojas H.; Norheim, Gunnstein; Hoe, J . Claire; Rollier, Christine S.; Nagaputra, Jerry C.; Makepeace, Katherine; Saleem, Muhammad; Chan, Hannah; Ferguson, David J. P.; Jones, Claire; Sadarangani, Manish; Hood, Derek W.; Feavers, Ian; Derrick, Jeremy P.; Pollard, Andrew J.; Moxon, E . Richard

    2014-01-01

    Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified glycoform structures (LgtE and IcsB) of detoxified penta-acylated LPS exhibited differential adjuvant properties when formulated as native outer membrane vesicles (nOMVs) as compared to the previously described LgtB variant. Detoxified penta-acylated LPS was obtained by disruption of the lpxL1 gene (LpxL1 LPS), and three different glycoforms were obtained by disruption of the lgtB, lgtE or icsB genes respectively. Mice (mus musculus) were immunized with a recombinant PorA P1.7-2,4 (rPorA) protein co-administered with different nOMVs (containing a different PorA serosubtype P1.7,16), each of which expressed one of the three penta-acylated LPS glycoforms. All nOMVs induced IgG responses against the rPorA, but the nOMVs containing the penta-acylated LgtB-LpxL1 LPS glycoform induced significantly greater bactericidal activity compared to the other nOMVs or when the adjuvant was Alhydrogel. Compared to LgtE or IcsB LPS glycoforms, these data support the use of nOMVs containing detoxified, modified LgtB-LpxL1 LPS as a potential adjuvant for future meningococcal protein vaccines. PMID:25545241

  14. Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity.

    PubMed

    Giuntini, Serena; Pajon, Rolando; Ram, Sanjay; Granoff, Dan M

    2015-04-01

    Among 25 serogroup B Neisseria meningitidis clinical isolates, we identified four (16%) with high factor H binding protein (FHbp) expression that were resistant to complement-mediated bactericidal activity of sera from mice immunized with recombinant FHbp vaccines. Two of the four isolates had evidence of human FH-dependent complement downregulation independent of FHbp. Since alternative complement pathway recruitment is critical for anti-FHbp bactericidal activity, we hypothesized that in these two isolates binding of FH to ligands other than FHbp contributes to anti-FHbp bactericidal resistance. Knocking out NspA, a known meningococcal FH ligand, converted both resistant isolates to anti-FHbp susceptible isolates. The addition of a nonbactericidal anti-NspA monoclonal antibody to the bactericidal reaction also increased anti-FHbp bactericidal activity. To identify a role for FH ligands other than NspA or FHbp in resistance, we created double NspA/FHbp knockout mutants. Mutants from both resistant isolates bound 10-fold more recombinant human FH domains 6 and 7 fused to Fc than double knockout mutants prepared from two sensitive meningococcal isolates. In light of recent studies showing functional FH-PorB2 interactions, we hypothesized that PorB3 from the resistant isolates recruited FH. Allelic exchange of porB3 from a resistant isolate to a sensitive isolate increased resistance of the sensitive isolate to anti-FHbp bactericidal activity (and vice versa). Thus, some PorB3 variants functionally bind human FH, which in the presence of NspA enhances anti-FHbp resistance. Combining anti-NspA antibodies with anti-FHbp antibodies can overcome resistance. Meningococcal vaccines that target both NspA and FHbp are likely to confer greater protection than either antigen alone. PMID:25644002

  15. Immunogenicity studies with a genetically engineered hexavalent PorA and a wild-type meningococcal group B outer membrane vesicle vaccine in infant cynomolgus monkeys.

    PubMed

    Rouppe van der Voort, E; Schuller, M; Holst, J; de Vries, P; van der Ley, P; van den Dobbelsteen, G; Poolman, J

    2000-01-31

    The immunogenicity of two meningococcal outer membrane vesicle (OMV) vaccines, namely the Norwegian wild-type OMV vaccine and the Dutch hexavalent PorA OMV vaccine, were examined in infant cynomolgus monkeys. For the first time, a wild-type- and a recombinant OMV vaccine were compared. Furthermore, the induction of memory and the persistence of circulating antibodies were measured. The Norwegian vaccine contained all four classes of major outer membrane proteins (OMP) and wild-type L3/L8 lipopolysaccharide (LPS). The Dutch vaccine consisted for 90% of class 1 OMPs, had low expression of class 4 and 5 OMP, and GalE LPS. Three infant monkeys were immunised with a human dose at the age of 1.5, 2.5 and 4.5 months. Two monkeys of each group received a fourth dose at the age of 11 months. In ELISA, both OMV vaccines were immunogenic and induced booster responses, particularly after the fourth immunisation. The Norwegian vaccine mostly induced sero-subtype P1.7,16 specific serum bactericidal antibodies (SBA), although some other SBA were induced as well. The antibody responses against P1.7,16, induced by the Norwegian vaccine, were generally higher than for the Dutch vaccine. However, the Dutch vaccine induced PorA specific SBA against all six sero-subtypes included in the vaccine showing differences in the magnitude of SBA responses to the various PorAs. PMID:10618530

  16. Obtención de la curva de luz en la ocultación de 35 Sgr por Júpiter el 6 de marzo de 1996

    NASA Astrophysics Data System (ADS)

    Paolantonio, S.; Duffard, R.; Carranza, G.

    La ocultación de la estrella de quinta magnitud 35 Sgr por Júpiter, se produjo el 6 de Marzo de 1996 a las 13 hs. TU. El objetivo era medir el cambio del flujo de la estrella en el ingreso y egreso por el limbo del planeta. Con estos datos se pueden determinar parámetros físicos del planeta (radio, eccentricidad) y de su atmósfera (escala de altura, temperatura, densidad, presión) Para lograr ésto se programó la cámara CCD TH 7896 1024 x 1025 instalada en el telescopio de 1.54 m de Bosque Alegre con el objetivo de lograr 2 imágenes por segundo. De esta forma se obtuvieron 2100 imágenes de la inmersión y otras tantas de la emersión. Hubo que tener grandes precauciones para evitar la saturación del CCD ya que la observación se realizó de día. En este momento las imágenes se encuentran en el Department of Planetary Sciences, Lunar and Planetary Laboratory, University of Arizona, para su reducción.

  17. Pincharse sin infectarse: estrategias para prevenir la infección por el VIH y el VHC entre usuarios de drogas inyectables

    PubMed Central

    MATEU-GELABERT, P.; FRIEDMAN, S.; SANDOVAL, M.

    2011-01-01

    Resumen Objetivo Desde principios de los noventa, en la ciudad de Nueva York se han implementado con éxito programas para reducir la incidencia del virus de la inmunodeficiencia humana (VIH) y, en menor medida, del virus de la hepatitis C (VHC). A pesar de ello, aproximadamente el 70% de los usuario de drogas inyectables (UDI) están infectados por el VHC. Queremos investigar cómo el 30% restante se las ha arreglado para no infectarse. El Staying safe (nombre original del estudio) explora los comportamientos y mecanismos que ayudan a evitar la infección por el VHC y el VIH a largo plazo. Material y métodos Hemos utilizado el concepto de «desviación positiva» aplicado en otros campos de salud pública. Estudiamos las estrategias, prácticas y tácticas de prevención de aquellos UDI que, viviendo en contextos de alta prevalencia, se mantienen sin infectar por VIH y el VHC, a pesar de haberse inyectado heroína durante años. Los resultados preliminares presentados en este artículo incluyen el análisis de las entrevistas realizadas a 25 UDI (17 doble negativos, 3 doble positivos y 5 con infección por el VHC y sin infección por el VIH). Se usaron entrevistas semiestructuradas que exploraban con detalle la historia de vida de los sujetos, incluyendo su consumo de drogas, redes sociales, contacto con instituciones, relaciones sexuales y estrategias de protección y vigilancia. Resultados La intencionalidad es importante para no infectarse, especialmente durante períodos de involución (períodos donde hay un deterioro económico y/o social que llevan al que se inyecta a situaciones de mayor riesgo). Presentamos tres dimensiones independientes de intencionalidad que conllevan comportamientos que pueden ayudar a prevenir la infección: a) evitar «el mono» (síntomas de abstención) asegurando el acceso a la droga; b) «llevarlo bien» para no convertirse en un junkie y así evitar la «muerte social» y la falta de acceso a los recursos, y c) seguir sin

  18. DIAMOND ALKALI OU2 - PASSAIC RIVER STUDY AREA

    EPA Science Inventory

    EPA, the U.S. Army Corps of Engineers (Corps), New Jersey Department of Transportation (NJDOT) ), National Oceanic and Atmospheric Administration (NOAA), U.S. Fish and Wildlife Service (USFWS) and New Jersey Department of Environmental Protection (NJDEP) are conducting a joint st...

  19. Analyse de l'effet des courants induits sur l'impédance d'un système électromagnétique alimenté en tension BF ou HF. Utilisation de la méthode des circuits couplés

    NASA Astrophysics Data System (ADS)

    Maouche, B.; Feliachi, M.

    1997-10-01

    In this paper, a study of the interaction between the inductor and the load of an axisymmetrical induction device is proposed. This interaction concerns the effect of the eddy current on both the excitation current and on the system impedance. A half analytical model, based on a numerical discretization of the electromagnetic solution domain, is used. In each cell of the numerical discretization, an analytical calculation using the Moment Method (MM) is considered. In the case of strong skin effect (High Frequency: HF), the formulation makes use of the Impedance Boundary Condition (IBC); in the contrary case (Low Frequency: LF), the interior domain is discretized. Dans cet article nous proposons l'étude de l'influence d'une charge (induit) conductrice sur la répartition du courant inducteur ainsi que sur l'impédance du système. L'inducteur est à géométrie axisymétrique de forme solénoïdale ou pancake destiné au chauffage par induction. Une méthode semi-analytique, basée sur une discrétisation du domaine en mailles élémentaires auxquelles s'applique une formulation intégrale (Méthode des Circuits Couplés : MCC) des grandeurs électromagnétiques, est utilisée. Dans le cas où l'effet de peau est important (Haute Fréquence:HF), la formulation associe la Condition d'Impédance de Surface; dans le cas contraire (Basse Fréquence : BF), un maillage du domaine interne est pratiqué.

  20. [Ag20 {S2 P(OR)2 }12 ]: A Superatom Complex with a Chiral Metallic Core and High Potential for Isomerism.

    PubMed

    Dhayal, Rajendra S; Lin, Yan-Ru; Liao, Jian-Hong; Chen, Yuan-Jang; Liu, Yu-Chiao; Chiang, Ming-Hsi; Kahlal, Samia; Saillard, Jean-Yves; Liu, C W

    2016-07-11

    The synthesis and structural determination of a silver nanocluster [Ag20 {S2 P(OiPr)2 }12 ] (2), which contains an intrinsic chiral metallic core, is produced by reduction of one silver ion from the eight-electron superatom complex [Ag21 {S2 P(OiPr)2 }12 ](PF6 ) (1) by borohydrides. Single-crystal X-ray analysis displays an Ag20 core of pseudo C3 symmetry comprising a silver-centered Ag13 icosahedron capped by seven silver atoms. Its n-propyl derivative, [Ag20 {S2 P(OnPr)2 }12 ] (3), can also be prepared by the treatment of silver(I) salts and dithiophosphates in a stoichiometric ratio in the presence of excess amount of [BH4 ](-) . Crystal structure analyses reveal that the capping silver-atom positions relative to their icosahedral core are distinctly different in 2 and 3 and generate isomeric, chiral Ag20 cores. Both Ag20 clusters display an emission maximum in the near IR region. DFT calculations are consistent with a description within the superatom model of an 8-electron [Ag13 ](5+) core protected by a [Ag7 {S2 P(OR)2 }12 ](5-) external shell. Two additional structural variations are predicted by DFT, showing the potential for isomerism in such [Ag20 {S2 P(OR)2 }12 ] species. PMID:27189869

  1. A survey of homopteran species (Auchenorrhyncha) from coffee shrubs and poró and laurel trees in shaded coffee plantations, in Turrialba, Costa Rica.

    PubMed

    Rojas, L; Godoy, C; Hanson, P; Hilje, L

    2001-01-01

    A survey of homopteran species (Auchenorryncha) was conducted in coffee plantations with no shade (C), and in those with shade of either poró (Erythrina poeppigiana) (CP) or poró plus laurel (Cordia alliodora) (CPL), in Turrialba, Costa Rica. A total of 130 species in ten families were collected, dominated by Cicadellidae (82 species). Species richness was highest in the CP system (88), followed by CPL (74) and C systems (60). Five most common species for all systems were Fusigonalia lativittata, Hebralebra nicaraguensis, Neocoelidia sp., Oliarus sp. and Clastoptera sp. Diversification of the coffee agroecosystem favors some species while limiting others, and have no effect on the majority of species. Thus, only F. lativittata, Neocoelidia sp. and Scaphytopius ca. latidens were well represented in all systems, but were more abundant in coffee shrubs. Additionally, the following were the dominant species in each system: Graphocephala sp. 1 (C), F. lativittata (CP) and H. nicaraguensis (CPL). Four species abundant on laurel trees, including H. nicaraguensis, appeared almost exclusively on these tree species. Species similarity was highest on the CP and CPL systems (51% of the species in common), followed by the C and CP (39%) and the C and CPL systems (38%). These findings show that even disturbed systems can harbor many insect species, so that they deserve attention from conservation advocates and biologists. PMID:12189787

  2. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori1

    PubMed Central

    Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo

    2014-01-01

    RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las

  3. A UV-vis study of the effects of alcohols on formation and stability of Mn(por)(O)(OAc) complexes

    NASA Astrophysics Data System (ADS)

    Mohajer, Daryoush; Jahanbani, Maryam

    2012-06-01

    Interactions of three different (acetato) (tetraarylporphyrinato) manganese (III) MnIII(por) with tetra-n-butylammonium hydrogen monopersulfate (n-Bu4NHSO5), in the presence of excess tetra-n-butylammonium acetate (n-Bu4NOAc) and in the absence or presence of various alcohols (alcohols = CH3OH, C2H5OH, i-C3H7OH, t-C4H9OH) in CH2Cl2, were monitored by their UV-vis spectral changes, under identical conditions, at room temperature. (Acetato) (tetrakispentafluorophenylporphyrinato) manganese (III) MnIII(tpfpp)(OAc) and (acetato) (tetramesitylporphyrinato) manganese (III) MnIII(tmp)(OAc) produced their corresponding high valent Mn(tpfpp)(O)(OAc) and Mn(tmp)(O)(OAc) both in the absence or presence of alcohols. Whereas, (acetato) (tetraphenylporphyrinato) manganese (III) MnIII(tpp)(OAc) only generated Mn(tpp)(O)(OAc) in the presence of less bulky alcohols. In the absence of alcohols or in the presence of t-C4H9OH, the UV-vis spectra displayed a very weak sign of formation of Mn(tpp)(O)(OAc) complex. It was observed that alcohols generally increased the rate of formation of Mn-oxo species in accordance with their acidity or hydrogen bonding strength, and enhanced the stability of Mn-oxo complexes, as their size increases. Attempts are made to explain these effects. A mechanistic scheme is also suggested for the decomposition of HSO5- to O2 and HSO4-, through the formation and dimerization of Mn-oxo species.

  4. Estudio teórico de la desorción de Na y K de SiO2 estimulada por la acción de fotones o electrones

    NASA Astrophysics Data System (ADS)

    Domínguez Ariza, D.; López, N.; Illas, F.; Pacchioni, G.; Madey, T. E.

    Se ha estudiado el mecanismo de generación de sodio y potasio atómico a partir de muestras de SiO2 utilizando cálculos basados tanto en la teoría del funcional de la densidad como en métodos post-Hartree Fock, así como en el método de cluster para modelar el sólido. Como consecuencia del estudio se han propuesto distintos caminos posibles para la desorción, estimulada por la acción de fotones o electrones, de sodio y potasio desde el óxido de silicio, proporcionando por lo tanto una explicación a la atmósfera tenue de sodio y potasio de La Luna.

  5. Health and safety plan for operations performed for the Environmental Restoration Program. Task, OU 1-03 and OU 4-10 Track 2 investigations

    SciTech Connect

    Trippet, W.A. II; Reneau, M.; Morton, S.L.

    1992-04-01

    This document constitutes the generic health and safety plan for the Environmental Restoration Program (ERP). It addresses the health and safety requirements of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA); Occupational Safety and Health Administration (OSHA) 29 CFR 1910.120 standard; and EG&G Idaho, Inc. This plan is a guide to individuals who must complete a health and safety plan for a task performed for the EPR. It contains a task specific addendum that, when completed, specifically addresses task specific health and safety issues. This health and safety plan reduces the time it takes to write a task specific health and safety plan by providing discussions of requirements, guidance on where specific information is located, and specific topics in the Addendum that must be discussed at a task level. This format encourages a complete task specific health and safety plan and a standard for all health and safety plans written for ERP.

  6. La inserción en el mercado laboral de los inmigrantes latinos en España y en los Estados Unidos: Diferencias por país de origen y estatus legal

    PubMed Central

    Connor, Phillip; Massey, Douglas

    2013-01-01

    Resumen Este artículo compara los resultados económicos entre los inmigrantes latinoamericanos en España y Estados Unidos. Detectamos un efecto de selección por el que la mayoría de los inmigrantes latinoamericanos en España proceden de Sudamérica de un entorno de clases medias, mientras la mayoría de los inmigrantes que van a los Estados Unidos son centroamericanos de clase baja. Este efecto de selección explica las diferencias transnacionales en la probabilidad de empleo, logro ocupacional y salarios obtenidos. A pesar de las diferencias en los orígenes y las características de los latinoamericanos en ambos países, los factores demográficos, humanos y de capital social parecen operar de forma similar en ambos países; y cuando los modelos se estiman separadamente por estatus legal, descubrimos que los efectos se acentúan más entre los inmigrantes irregulares cuando se los compara con los regulares, especialmente en Estados Unidos. PMID:24532857

  7. The Understanding of Astronomy Concepts by Students from Basic Education of a Public School. (Spanish Title: El Entendimiento de Conceptos de Aastronmía Por Los Alumnos de Educación Básica en Una Escuela Pública.) O Entendimento de Conceitos de Astronomia Por Alunos da Educação Básica: O Caso de Uma Escola Pública Brasileira

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel; dos Santos, Carlos

    2011-07-01

    We present the results obtained in a research on the comprehension of basic astronomical concepts, in which 561 students from fifth grade middle school to third grade high school of a public school of the city of Foz do Iguaçu (Brazil) took part. A test with 20 multiple-choice questions was applied to indentify the most common conceptions expressed by the students. This test was elaborated based on the literature about misconceptions and covered the following topics: the day-night cycle; the time zones; the seasons of the year; the phases of the Moon; the movement of the Moon; the apparent movement of the Sun in the celestial sphere; the eclipses; the dimensions and distances in the Universe; the brightness of the stars and its observation from Earth. Though a small progress was verified in the proportion of scientifically acceptable answers when comparing the eighth grade of middle school to the fifth, and the third grade of high school to the first, there was an overall predominance of alternative conceptions regarding most of the explored subjects, which persisted up to the last year of secondary school. The comparison to data found in this research made in other socio-cultural contexts revealed, in many aspects, similar notions and difficulties revealed by the students. Se presentan los resultados de una investigación sobre la comprensión de conceptos astronómicos básicos, en la cual participaron 561 estudiantes que cursaban entre el quinto grado de la enseñanza primaria y el tercer año de la enseñanza secundaria de una escuela pública de la ciudad de Foz do Iguaçu (Brasil). Se utilizó un test de 20 preguntas de opción múltiple para identificar las concepciones más comunes expresadas por los estudiantes. Este instrumento de recolección de datos se desarrolló en base a la literatura sobre las concepciones alternativas y trató los siguientes temas: el ciclo día-noche, los husos horarios, las estaciones del año, las fases de la Luna, el

  8. The Understanding of Astronomy Concepts by Students from Basic Education of a Public School. (Spanish Title: El Entendimiento de Conceptos de Aastronmía Por Los Alumnos de Educación Básica en Una Escuela Pública.) O Entendimento de Conceitos de Astronomia Por Alunos da Educação Básica: O Caso de Uma Escola Pública Brasileira

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel; dos Santos, Carlos

    2011-07-01

    We present the results obtained in a research on the comprehension of basic astronomical concepts, in which 561 students from fifth grade middle school to third grade high school of a public school of the city of Foz do Iguaçu (Brazil) took part. A test with 20 multiple-choice questions was applied to indentify the most common conceptions expressed by the students. This test was elaborated based on the literature about misconceptions and covered the following topics: the day-night cycle; the time zones; the seasons of the year; the phases of the Moon; the movement of the Moon; the apparent movement of the Sun in the celestial sphere; the eclipses; the dimensions and distances in the Universe; the brightness of the stars and its observation from Earth. Though a small progress was verified in the proportion of scientifically acceptable answers when comparing the eighth grade of middle school to the fifth, and the third grade of high school to the first, there was an overall predominance of alternative conceptions regarding most of the explored subjects, which persisted up to the last year of secondary school. The comparison to data found in this research made in other socio-cultural contexts revealed, in many aspects, similar notions and difficulties revealed by the students. Se presentan los resultados de una investigación sobre la comprensión de conceptos astronómicos básicos, en la cual participaron 561 estudiantes que cursaban entre el quinto grado de la enseñanza primaria y el tercer año de la enseñanza secundaria de una escuela pública de la ciudad de Foz do Iguaçu (Brasil). Se utilizó un test de 20 preguntas de opción múltiple para identificar las concepciones más comunes expresadas por los estudiantes. Este instrumento de recolección de datos se desarrolló en base a la literatura sobre las concepciones alternativas y trató los siguientes temas: el ciclo día-noche, los husos horarios, las estaciones del año, las fases de la Luna, el

  9. [Consultations in oncological supportive care mono-, multi-, ou interdisciplinary: What should we favour?].

    PubMed

    Garnier, Stéphanie Ranque; Pelletti, Caroline; Quenard, Christelle; Vallet, Fabienne; Lemoine, Patrick; Guastella, Virginie; Rhondali, Wadih

    2015-09-01

    According to the point 7.6 and 7.7 of the Cancer Plan 2014, all cancer patients should have access to supportive care. Indeed, the supportive care consultation in oncology is an important tool for the symptom management of cancer patients at all times of treatment. This consultation can be mono-disciplinary or multi-disciplinary (with different professions: physician, nurse, psychologist, social service assistant…) with or without integration (multidisciplinary or interdisciplinary). There are few studies focusing on the types of consultations (mono- or multidisciplinary) to promote based on their expected outcomes. After describing the different types of consultations (initial, follow-up, unscheduled, discharge) and having highlighted the main issues of these consultations, we will present the possible configurations. Our discussion will concern then the advantages and disadvantages of monodisciplinarity and different types of multidisciplinary highlighting the possible improvements. At the end of this work, after a brief synthesis of the different outcomes associated with each type of consultation, we would like to discuss the type of consultation to choose according to the outcomes. PMID:26031300

  10. Using statistics to determine data adequacy for environmental policy decisions (shootout at the OU-3 corral)

    SciTech Connect

    Kelly, E.; Campbell, K.; Michael, D.; Black, P.

    1998-12-31

    The discipline of statistics often plays an important role in environmental policy decision-making, when decisions are, if not completely based on, at least informed by environmental data. Statistics provides guidance for the type, quantity, and quality of data required to support the policy decisions, as well as the techniques for assessing the data once it is collected. Environmental policy decisions occur at many levels, national, regional, state, and local. This paper describes the use of statistics to support policy decisions at the local level. Even at the local level, decisions can involve millions and, in some cases, billions of dollars. Additionally, local policy decisions can have ramifications for policy decisions at the state, regional and national levels. The two major regulations that drive environmental restoration are the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (also known as Superfund), and the Resource Conservation and Recovery Act (RCRA). In many areas state water quality standards and other requirements are also important drivers. The United States Environmental Protection Agency (USEPA) has placed the statistician right in the center of the environmental restoration work. It has done this by issuing guidance that recommends that planning for environmental data collection follows the Data Quality Objectives (DQO) Process (USEPA 1994), and evaluation of the data follows the Data Quality Assessment (DQA) Process (USEPA 1996). These processes are based on formal statistical techniques such as hypothesis testing and estimation, and explicitly link data collection to risk management decisions through specification of acceptable levels for statistical decision errors.

  11. Le futur linguistique: temps lineaire ou temps ramifie (The Linguistic Future: Linear or Branching Time)?

    ERIC Educational Resources Information Center

    Martin, Robert

    1981-01-01

    Discusses the problems posed by a semantic analysis of the future tense in French, addressing particularly its double use as a tense and as a mood. The distinction between linear and branching time, or, certainty and possibility, central to this discussion, leads to a comparative analysis of future and conditional. (MES)

  12. Sources semiconductrices de photons uniques ou de photons jumeaux pour l'information quantique

    NASA Astrophysics Data System (ADS)

    Berger, Vincent; Gérard, Jean-Michel

    2003-07-01

    A large number of scientific proposals in recent years are based on transport and manipulation of information using single quantum objects. Although very impressive theoretical perspectives have been envisaged, experimental demonstrations are still limited due to technological difficulties with present state-of-the-art devices. This paper presents various approaches aiming at efficient single or twin photons semiconductor sources. The emergence of these devices will be an important technological breakthrough in the field of quantum information. To cite this article: V. Berger, J.-M. Gérard, C. R. Physique 4 (2003).

  13. L'exobiologie ou l'origine chimique de la vie

    NASA Astrophysics Data System (ADS)

    Brack, A.; Halbwachs, J.-L.

    2006-03-01

    By definition, exobiology includes the study of the origin, evolution and distribution of life in the universe, terrestrial life serving as a reference in our search for extraterrestrial life. On Earth, life emerged in water about 4 billion years ago with organised molecular systems capable of self-reproduction and also capable of evolution. It is generally agreed that its main ingredients were liquid water and organic molecules, i.e. skeletons of carbon atoms flanked by hydrogen, oxygen, nitrogen, sulfur and phosphorus atoms. Organic matter might have been formed in the primitive Earth's atmosphere or near hydrothermal vents. A large fraction of prebiotic organic molecules might have been brought by extraterrestrial meteoritic and cometary dust grains decelerated by the atmosphere. The possibility that life might have evolved on early Mars, when water existed on the surface, marks it as a prime candidate in the search for microbial life beyond the Earth. Europa has an icy carapace and probably a subsurface region of water which might harbor a basic life form. The atmosphere and surface components of Titan are also of interest to exobiology for the insight into a hydrocarbon-rich, chemically evolving world. Furthermore, the detection of interstellar organic molecules and the discovery of extrasolar planets broaden the field of astrobiology to the whole Universe.

  14. Mercury speciation modeling using site specific chemical and redox data from the TNXOD OU

    SciTech Connect

    Kaplan, D.I.

    2000-03-22

    The objective of this study was to evaluate mercury speciation under reducing conditions expected in sediments at the TNX Outfall Delta Operable Unit. These changes in speciation would then be used to infer whether mercury toxicity and mobility would be expected to be significantly altered under reducing conditions. The results from this work suggest that mercury would likely become more strongly retained by the solid phase under reducing conditions than under oxidizing conditions at the TNX Outfall Delta Site. Considering that experimental results indicate that mercury is extremely tightly bound to the solid phase under oxidizing conditions, little mercury mobility would therefore be expected under reducing conditions.

  15. High explosive spot test analyses of samples from Operable Unit (OU) 1111

    SciTech Connect

    McRae, D.; Haywood, W.; Powell, J.; Harris, B.

    1995-01-01

    A preliminary evaluation has been completed of environmental contaminants at selected sites within the Group DX-10 (formally Group M-7) area. Soil samples taken from specific locations at this detonator facility were analyzed for harmful metals and screened for explosives. A sanitary outflow, a burn pit, a pentaerythritol tetranitrate (PETN) production outflow field, an active firing chamber, an inactive firing chamber, and a leach field were sampled. Energy dispersive x-ray fluorescence (EDXRF) was used to obtain semi-quantitative concentrations of metals in the soil. Two field spot-test kits for explosives were used to assess the presence of energetic materials in the soil and in items found at the areas tested. PETN is the major explosive in detonators manufactured and destroyed at Los Alamos. No measurable amounts of PETN or other explosives were detected in the soil, but items taken from the burn area and a high-energy explosive (HE)/chemical sump were contaminated. The concentrations of lead, mercury, and uranium are given.

  16. T-REX OU4 HIRES: the high resolution spectrograph for the E-ELT

    NASA Astrophysics Data System (ADS)

    Oliva, E.; Baffa, C.; Busoni, L.; Carbonaro, L.; Cresci, G.; Del Vecchio, C.; Esposito, S.; Ferruzzi, D.; Giani, E.; Iuzzolino, M.; Massi, F.; Miglietta, L.; Pinna, E.; Riccardi, A.; Sanna, N.; Sozzi, M.; Tozzi, A.; Curti, M.; Faggi, S.; Marconi, A.; Bragaglia, A.; Montegriffo, P.; Origlia, L.; Bruno, P.; Munari, M.; Scuderi, S.; Leone, F.; Genoni, M.; Landoni, M.; Poretti, E.; Riva, M.; Zerbi, F.; Carleo, I.; Gratton, R.; Antoniucci, S.; Li Causi, G.; Nisini, B.; Vitali, F.; Cirami, R.; Coretti, I.; Cristiani, S.; Cupani, G.; D'Odorico, V.; Di Marcantonio, P.; Molaro, P.; Viel, M.

    The goal of this unit was to consolidate the project for the construction of the high resolution spectrometer of the E-ELT (HIRES). The task included the development of scientific cases and tools to predict the instrumental performances. From the technical point of view it included several R&D activities in collaboration with highly specialized Italian companies; it culminated with the detailed design of a highly modular instrument based on well established technologies. From the management point of view it lead to the consolidation of a large international consortium that spans over 12 countries and includes most of the European and ESO-related institutes interested in high resolution spectroscopy. This consortium is led by INAF; its formal creation is awaiting the official call by ESO for the phase-A study for the HIRES instrument of the E-ELT.

  17. Utiliser la Dimension Europeenne Pour Faire Sortir l'Ecole de ses Murs ou "Extra Muros."

    ERIC Educational Resources Information Center

    Champollion, Pierre

    2002-01-01

    Five European institutions devoted to principal training developed the Comenius project "Extra Muros" between 1996-99. Its objectives were understanding the importance of educative action outside the school in order to provide equal opportunity to all students, as well as to promote the awareness of Europe among schools. The project facilitates…

  18. Flow Model Development for the Idaho National Laboratory OU 10-08 Sitewide Groundwater Model

    SciTech Connect

    Hai Huang; Swen Magnuson; Thomas Wood

    2005-09-01

    A two-dimensional (2D), steady-state groundwater flow model was developed for the Idaho National Laboratory (INL) sitewide groundwater model. A total of 224 wells inside the model domain were used to calibrate the 2D flow model. Three different calibration techniques, zonation approach, pilot point approach and coupled zonation/pilot point approach, were explored and applied during the model development. The pilot point approach allows modelers to model aquifer heterogeneities at various scales, and extract the maximum amount of data from available monitoring data, permitting the best possible representation of flow and transport at the INL.

  19. Professionnalisation ou Deprofessionnalisation: Une Base Conceptuelle pour L'evaluation de La Competence en Psychologie.

    ERIC Educational Resources Information Center

    Perron, Jacques; And Others

    1980-01-01

    Elements of professionalization--systematic body of theory, social recognition, monopoly, and degree of organization--are presented and applied to the development of professional psychology in Quebec. The concept of deprofessionalization is introduced as an alternative basis for evaluating competence in professional psychology. (Author)

  20. Qubit-Photon Entanglement and Hong-Ou-Mandel Interference with Propagating Microwaves

    NASA Astrophysics Data System (ADS)

    Eichler, Christopher; Lang, Christian; Fink, Johannes; Govenius, Joonas; Steffen, Lars; Filipp, Stefan; Wallraff, Andreas; Woolley, Matthew; Blais, Alexandre

    2013-03-01

    Itinerant microwave photons offer an attractive carrier of quantum information in superconducting circuits. However, until recently it remained challenging to measure photon statistics and coherence properties of microwave fields beyond the Gaussian level - mainly due to the absence of efficient detectors in this frequency range. Here, we present the on-demand generation and efficient characterization of microwave radiation and its entanglement with stationary qubits. Based on novel tomography techniques and low noise parametric amplification we are able to resolve all relevant quantum correlations between the propagating field and the superconducting qubit to demonstrate entanglement with high fidelity. We have also created entangled microwave fields traveling in two spatially separated modes. Making use of the two-photon interference at a microwave beamsplitter we are able to prepare propagating NOON-type states, which we fully characterize by measuring the joint photon statistics of the two modes. The possibility to synthesize, guide and detect entanglement correlations between itinerant microwave photons and stationary qubits put microwave based quantum network experiments within reach.

  1. Integrated assessment of groundwater resources in the Ouémé basin, Benin, West Africa

    NASA Astrophysics Data System (ADS)

    Barthel, R.; Sonneveld, B. G. J. S.; Götzinger, J.; Keyzer, M. A.; Pande, S.; Printz, A.; Gaiser, T.

    An integrated assessment of groundwater resources in Benin, West Africa was performed within the framework of the EC-funded research project RIVERTWIN ( www.rivertwin.org). The assessment included a spatial analysis of groundwater relevant parameters taken from more than 4000 wells stored in a countrywide water database (BDI - Banque des Données Intégrée) and an estimation of the spatial and temporal distribution of groundwater recharge using a modified version of the hydrological model HBV. Additionally, a socio-economic assessment of the impacts of groundwater availability and accessibility on national health issues as well as an assessment of groundwater development costs was carried out. The analysis revealed particularly unfavourable conditions for groundwater use in the northern part of the country where groundwater recharge during the wet season does not lead to the formation of persistent groundwater storage in its shallow, unconfined aquifers. Poor storage capacity and hydraulic properties of the deeper fractured aquifers additionally limit the capacity of individual wells to capture groundwater recharge. Including climate change scenarios forecasting less precipitation (generated from global climate models (GCM) based on IPCC scenarios) indicates that the situation in water scarce regions will worsen, as recharge volumes lessen and occur over a shorter time period. Drilling more wells may be a limited option to capture larger portions of the recharge, since the capture zone and therefore the regional influence of existing wells is rather small. In the south, deeper confined aquifers guarantee better and more reliable yields, yet the lack of long-term monitoring and groundwater age data does not allow an appraisal of the limits of the sustainable use of these aquifers. Finally, it has been shown that access to suitable aquifers and diarrhea prevalence are spatially correlated. Access to groundwater is thereby not only a function of aquifer suitability and groundwater availability but a function of well development (mainly drilling) costs as well. The present study can be seen as a first attempt of an integrated evaluation of the groundwater resources and the development options based on the BDI data set. However, it can clearly be seen that the amount, nature and reliability of the data currently available is not sufficient to come to a clear, spatially explicit description of groundwater resources in the country. Improved monitoring and the use of advanced data collection methods (isotopic analysis, remote sensing, fully coupled models of the hydrological cycle) are required to improve the understanding Benin’s groundwater resources.

  2. Des Ateliers de Philosophie a l'Ecole Elementaire: Idealisme ou Pragmatisme? Un Exemple en France.

    ERIC Educational Resources Information Center

    Bailleul, Marc

    2003-01-01

    After a brief description of a sequence of philosophical workshops, this article analyzes, first, the request of the teachers who enroll for the training courses offered, and second, the training course itself. This analysis is conducted through a model crossing the two axes: pragmatism/idealism and individualism/social coherence. (SM)

  3. Jeux droles ou droles de jeux. (Funny Games or Strange Games.)

    ERIC Educational Resources Information Center

    Care, Jean-Marc

    1983-01-01

    Role playing differs from the more static teaching technique of simulation in its incorporation of originality and theatricality. From preparation to presentation, it is important to retain the element of play, avoid techniques of or tendencies toward psychodrama, and hold the pedagogical or evaluative purposes in mind. (MSE)

  4. Characterization of fHbp, nhba (gna2132), nadA, porA, Sequence Type (ST), and Genomic Presence of IS1301 in Group B Meningococcal ST269 Clonal Complex Isolates from England and Wales▿

    PubMed Central

    Lucidarme, Jay; Comanducci, Maurizio; Findlow, Jamie; Gray, Stephen J.; Kaczmarski, Edward B.; Guiver, Malcolm; Kugelberg, Elisabeth; Vallely, Pamela J.; Oster, Philipp; Pizza, Mariagrazia; Bambini, Stefania; Muzzi, Alessandro; Tang, Christoph M.; Borrow, Ray

    2009-01-01

    Highly effective glycoconjugate vaccines exist against four of the five major pathogenic groups of meningococci: A, C, W-135, and Y. An equivalent vaccine against group B meningococci (menB) has remained elusive due to the poorly immunogenic capsular polysaccharide. A promising alternative, the investigational recombinant menB (rMenB)- outer membrane vesicle (OMV) vaccine, contains fHBP, NHBA (previously GNA2132), NadA, and outer membrane vesicles (OMVs) from the New Zealand MeNZB vaccine. MenB currently accounts for 90% of meningococcal disease in England and Wales, where the multilocus sequence type (ST) 269 (ST269) clonal complex (cc269) has recently expanded to account for a third of menB cases. To assess the potential cc269 coverage of the rMenB-OMV vaccine, English and Welsh cc269 isolates from the past decade were genetically characterized with respect to fHBP, NHBA, and NadA. All of the isolates harbored fHbp and nhba alleles, while 98% of the cc269 isolates were devoid of nadA. Subvariant profiling of fHbp, nhba, and porA against STs revealed the presence of two broadly distinct and well-defined clusters of isolates, centered around ST269 and ST275, respectively. An additional molecular marker, insertion sequence IS1301, was found to be present in 100% and <2% of isolates of the respective clusters. On the basis of the genetic data, the potential rMenB-OMV coverage of cc269 in England and Wales is high (up to 100%) within both clusters. Expression studies and serum bactericidal antibody assays will serve to enhance predictions of coverage and will augment ongoing studies regarding the significance of IS1301 within the ST269 cluster. PMID:19759227

  5. Characterization of invasive Neisseria meningitidis from Atlantic Canada, 2009 to 2013: With special reference to the nonpolysaccharide vaccine targets (PorA, factor H binding protein, Neisseria heparin-binding antigen and Neisseria adhesin A)

    PubMed Central

    Tsang, Raymond SW; Law, Dennis KS; Gad, Rita R; Mailman, Tim; German, Gregory; Needle, Robert

    2015-01-01

    BACKGROUND: Serogroup B Neisseria meningitidis (MenB) has always been a major cause of invasive meningococcal disease (IMD) in Canada. With the successful implementation of a meningitis C conjugate vaccine, the majority of IMD in Canada is now caused by MenB. OBJECTIVE: To investigate IMD case isolates in Atlantic Canada from 2009 to 2013. Data were analyzed to determine the potential coverage of the newly licensed MenB vaccine. METHODS: Serogroup, serotype and serosubtype antigens were determined from IMD case isolates. Clonal analysis was performed using multilocus sequence typing. The protein-based vaccine antigen genes were sequenced and the predicted peptides were investigated. RESULTS: The majority of the IMD isolates were MenB (82.5%, 33 of 40) and, in particular, sequence type (ST)-154 B:4:P1.4 was responsible for 47.5% (19 of 40) of all IMD case isolates in Atlantic Canada. Isolates of this clone expressed the PorA antigen P1.4 and possessed the nhba genes encoding for Neisseria heparin-binding antigen peptide 2, which together matched exactly with two of the four components of the new four-component meningococcal B vaccine. Nineteen MenB isolates had two antigenic matches, another five MenB and one meningitis Y isolate had one antigenic match. This provided 75.8% (25 of 33) potential coverage for MenB, or a 62.5% (25 of 40) overall potential coverage for IMD. CONCLUSION: From 2009 to 2013, IMD in Atlantic Canada was mainly caused by MenB and, in particular, the B:4:P1.4 ST-154 clone, which accounted for 47.5% of all IMD case isolates. The new four-component meningococcal B vaccine appeared to offer adequate coverage against MenB in Atlantic Canada. PMID:26744586

  6. Characterization of fHbp, nhba (gna2132), nadA, porA, and Sequence Type in Group B Meningococcal Case Isolates Collected in England and Wales during January 2008 and Potential Coverage of an Investigational Group B Meningococcal Vaccine▿

    PubMed Central

    Lucidarme, Jay; Comanducci, Maurizio; Findlow, Jamie; Gray, Stephen J.; Kaczmarski, Edward B.; Guiver, Malcolm; Vallely, Pamela J.; Oster, Philipp; Pizza, Mariagrazia; Bambini, Stefania; Muzzi, Alessandro; Borrow, Ray

    2010-01-01

    Invasive disease caused by meningococcal capsular groups A, C, W-135, and Y is now preventable by means of glycoconjugate vaccines that target their respective polysaccharide capsules. The capsule of group B meningococci (MenB) is poorly immunogenic and may induce autoimmunity. Vaccines based on the major immunodominant surface porin, PorA, are effective against clonal epidemics but, thus far, have a limited scope of coverage against the wider MenB population at large. In an alternative approach, the first-generation, investigational, recombinant MenB (rMenB) plus outer membrane vesicle (OMV) (rMenB-OMV) vaccine contains a number of relatively conserved surface proteins, fHBP, NHBA (previously GNA2132), and NadA, alongside PorA P1.4-containing OMVs from the New Zealand MeNZB vaccine. MenB currently accounts for approximately 90% of cases of meningococcal disease in England and Wales. To assess potential rMenB-OMV vaccine coverage of pathogenic MenB isolates within this region, all English and Welsh MenB case isolates from January 2008 (n = 87) were genetically characterized with respect to fHBP, NHBA, NadA, and PorA. Alleles for fHbp, nhba, and porA were identified in all of the isolates, of which 22% were also found to harbor nadA alleles. On the basis of genotypic data and predicted immunological cross-reactivity, the potential level of rMenB-OMV vaccine coverage in England and Wales ranges from 66% to 100%. PMID:20375242

  7. Neisseria gonorrhoeae antimicrobial susceptibility in Barcelona: penA, ponA, mtrR, and porB mutations and NG-MAST sequence types associated with decreased susceptibility to cephalosporins.

    PubMed

    Serra-Pladevall, J; Barberá, M J; Rodriguez, S; Bartolomé-Comas, R; Roig, G; Juvé, R; Andreu, A

    2016-09-01

    The aims of this study were to determine the antimicrobial susceptibility of Neisseria gonorrhoeae (NG) in our area, to analyze the molecular mechanisms involved in cephalosporins resistance, and to undertake molecular typing of our NG strains. Antimicrobial susceptibility was determined using the Etest. The genes penA, mtrR, penB, and ponA were studied. Molecular typing was performed by N. gonorrhoeae multiantigen sequence typing. Of 329 strains analyzed in 2013, none showed high-level cephalosporin resistance, but 8.2 % had resistance to cefixime [minimum inhibitory concentration (MIC) > 0.125 μg/mL] and 0.6 % to ceftriaxone (MIC > 0.125 μg/mL). Azithromycin resistance was documented in 4.3 % and ciprofloxacin resistance in 49.2 %. Among 48 strains with an MIC ≥ 0.125 μg/mL to cefixime, 58.3 % showed the penA mosaic pattern XXXIV, 98 % a Leu → Pro substitution at position 421 of the ponA gene, 100 % amino acid changes at positions 101 and 102 of the PorB1b porin, and 87.5 % of strains an adenine deletion in the promoter region of the MtrC-D-E efflux pump. A significant difference between strains with and without decreased cephalosporin susceptibility (MIC ≥ 0.125 μg/mL) was observed for these four genes. Of the 48 strains with an MIC ≥ 0.125 μg/mL to cefixime, 43.8 % belonged to the genogroup G1407 and 27.1 % belonged to the genogroup G2400. A significant association of G1407 with decreased susceptibility (MIC ≥ 0.125 μg/mL) and G2992 with susceptibility was found, and also between G1407 and mosaic pattern XXXIV and between G2400 and A501T substitution in penA. The NG resistance rate in our area is higher than the median of Europe. We have detected the emergence of G2400, which may be a source of antimicrobial resistance. PMID:27255221

  8. Eficacia de la detección sistemática de la gripe en las fronteras en los viajeros que llegan por vía aérea*

    PubMed Central

    Priest, Patricia C.; Jennings, Lance C.; Duncan, Alasdair R.; Brunton, Cheryl R.; Baker, Michael G.

    2015-01-01

    Objetivos. Se midieron los síntomas y la prevalencia de la gripe (también llamada influenza), así como la eficacia del mecanismo de detección sistemática basado en los síntomas y la temperatura para diagnosticar la gripe en viajeros internacionales que llegaban por vía aérea. Métodos. El presente estudio transversal recopiló datos de viajeros que llegaron al aeropuerto internacional de Christchurch (Nueva Zelandia) en el invierno del 2008 mediante un cuestionario de salud, medición de la temperatura y toma de muestras de las vías respiratorias. Resultados. De los viajeros, 15 976 (68%) entregaron los formularios completos. De ellos, 17% notificaron al menos un síntoma de gripe; los síntomas más comunes fueron rinorrea o congestión nasal (10%) y tos (8%). Se tomaron muestras de las vías respiratorias de 3 769 viajeros. La prevalencia estimada de la gripe fue de 1,1% (4% en las personas sintomáticas, 0,2% en las asintomáticas). La sensibilidad de los criterios de detección varió de 84% para “cualquier síntoma” a 3% para la fiebre de 37,8 °C o mayor. El valor predictivo positivo fue bajo para todos los criterios. Conclusiones. El método de detección sistemática en las fronteras mediante la autonotificación de síntomas y la toma de la temperatura presenta limitaciones para impedir que una gripe pandémica entre en un país. Basarse en criterios como “cualquier síntoma” o la tos haría que se investigara a varias personas no infectadas, mientras que algunas personas infectadas pasarían inadvertidas. Si se usaran criterios más específicos como la fiebre, la mayoría de las personas infectadas entrarían en el país a pesar del mecanismo de detección.

  9. Formation des adultes ou transformation des structures de l'entreprise (Manpower Development or the Transformation of Industrial Structures).

    ERIC Educational Resources Information Center

    Caspar, Pierre

    This action research study describes how the Centre Universitaire de Cooperation Economique et Sociale (CUCES) set up an initial instructor training program for senior engineers in a large French cement firm and eventually progressed toward overall organizational change. Beginning with research methodology and some practical problems encountered…

  10. Ordinateurs: Efficaces ou pas? (La Perspective d'une Enseignante) (Computers: Effective or Not? [One Teacher's Perspective]).

    ERIC Educational Resources Information Center

    Pellerin, Micheline

    1999-01-01

    Examined the effectiveness of computer assisted language learning among two groups of students enrolled in an intermediate French course. One group of students spent more time each week in a computer laboratory than did a second group of students. Overall, students who spent more time in the laboratory had higher class averages at the end of the…

  11. Structure de l'univers - quand l'observation guide la théorie... ou pas

    NASA Astrophysics Data System (ADS)

    Nazé, Yaël

    The scientific method is often presented, e.g. to children, as a linear process, starting by a question and ending by the elaboration of a theory, with a few experiments in-between. The reality of the building of science is much more complex, with back-and-forth motions between theories and observations, with some intervention of technology and randomness. This complex process is not always correctly understood and assimilated, even amongst scientists. The hero cult, mixed with some revisionism, still exists despite in-depth historical studies. In this context, it may be useful to comparatively examine the reaction to crucial observations, their interpretation and their impact on the contemporaneous theory development. Four examples are presented here, all linked to the question of the 'construction of the heavens' but at different epochs.

  12. La conception de l'expérience scolaire aujourd'hui: Virage ou Évolution

    NASA Astrophysics Data System (ADS)

    Bordėleau, Louis-Gabriel

    1987-09-01

    The changes characterizing the conception and educational practices in the school environment nowadays are mainly manifest on the following three levels: the learner and his learning, the planning and implementation of school programmes and thirdly, the conception and practice of evaluation. These changes are strongly stimulated by the complex interaction of social, economic and technological transformations which are reshaping our present pluralistic society. The speed with which these social changes have taken place have forced the school to face two major challenges: firstly, to involve itself resolutely in decreasing the distance between school and society and secondly to define its own function in a more precise manner so as to take over its prescribed role of educational leadership in society. On the conceptional level with regard to the learner and the learning process, the author discerns an important tendency leading to a more integral vision. The sterile juxtapositioning of process and content is now being overcome. On the level of planning and implementation of school programmes several tendencies become apparent: the programmes tend to become more prescriptive and the school increases its stock of core subjects. These two tendencies try to integrate themselves in a policy of respect for individual differences. And finally it is recognized that the phase of implementation is of as critical importance if not more so than that of planning. The practices concerning evaluation seem at present to be influenced by recent social pressures demanding that the school provide education of greater quality which responds more adequately to the new challenges effected by a society in a state of tremendous evolution.

  13. Simulation d'un systeme de stockage saisonnier de glace pour la climatisation d'un batiment commercial ou institutionnel

    NASA Astrophysics Data System (ADS)

    Giraldo, Raul Alberto

    The principal goal of this study was to evaluate, using numerical simulation, the feasibility of an air conditioning system, supported by a seasonal ice storage system, installed in a commercial or institutional building. In this regard, the effects of changing several elements around the design of two possible scenarios were modeled in TRNSYS using Matlab® as a programming tool. In the first scenario, the air demanded inside the building passes directly through the ice storage system. In a second scenario, a closed loop pipe full of glycol transports the heat between the ice reservoir and an air cooling coil. First of all, the literature review shows some studies and earlier relevant applications, as well as different solving methods for moving boundary problems in a biphasic medium (waterice). Next, the heat load profile for a typical institutional building in Montreal is determined as a reference point using EE4 and three different methods of solving the boundary motion problem are compared for both, ice training and ice melting. Subsequently, the design parameters are presented for each scenario. This is followed by a description of the programming codes in Matlab® and the components that have been implemented in TRNSYS. Finally, the results involving the heat exchanged and the waterice boundary movements, among others, are collected for one year and for three years. The simulations of both scenarios have also included the experimental variation of some parameters such as the construction area for the ice reservoir, the duration of the ice melting period and other related physical variables. A final analysis of results was followed by an economic study, which considered the changes in initial investment and the potential energy savings for each scenario, compared with a traditional air conditioning unit. This showed that, although research is still needed on many improvements in the design of scenarios and whether its application is limited by several macroeconomic factors, a seasonal ice storage system is an appealing option in energy efficiency terms and it could potentially be, technically and ecologically, a good way to obtain energy savings.

  14. Canada's Kids: Thriving? Or Just Surviving? = Les enfants du Canada: Se developpent-ils bien ou vivotent-ils simplement?

    ERIC Educational Resources Information Center

    McCloskey, Donna, Ed.

    1997-01-01

    This quarterly journal issue (in English and French versions) includes the following articles: (1) "Canada's Kids: Thriving? Or Just Surviving?" (McCloskey, Donna), an overview of the latest research on the well-being of Canada's children; (2) "The Fence at the Edge of the Cliff: Approaching Family Policy in Canada" (Mirabelli, Alan), which…

  15. Biopuces pour le traitement de cellules vivantes : micromanipulation des cellules par voie électrique ou microfluidique

    NASA Astrophysics Data System (ADS)

    Le Pioufle, Bruno; Frénéa, Marie; Tixier, Agnès

    2004-06-01

    After a brief overview of the state of the art in the domain of cell biochips, and more particularly, the usual methods for cell placement and characterization on a chip, our research on highly parallelized cell placement on a chip is presented. Single cell arraying methods, using dielectrophoresis effects, or microfluidic effects produced by bulk micromachined sub-micrometric capillaries are compared. Target applications of such cell biochips cover the domain of gene transfer on a large population of cells, parallelized cell sorting, or drug high-throughput screening on living cells. To cite this article: B. Le Pioufle et al., C. R. Physique 5 (2004).

  16. Perles et saphirs ou comment parer votre expression francaise (Pearls and Sapphires or How to Embellish Your French Expression).

    ERIC Educational Resources Information Center

    Geno, Thomas H.

    1981-01-01

    Illustrates the pitfalls of French grammar and syntax by reproducing a student's composition, which mangles the language. Draws from similarly frustrating experiences and from a "New York Times" article entitled "The Fumble-rules of Grammar" to compile a list of "General Principles for the Improvement of Oral and Written French Expression." (MES)

  17. New halide-centered discrete Ag(I)(8) cubic clusters containing diselenophosphate ligands, [Ag(8)(X)[Se(2)P(OR)(2)](6)](PF(6)) (X = Cl, Br; R = Et, Pr, (i)Pr): syntheses, structures, and DFT calculations.

    PubMed

    Liu, C W; Haia, Hsien-Chung; Hung, Chiu-Mine; Santra, Bidyut Kumar; Liaw, Ben-Jie; Lin, Zhenyang; Wang, Ju-Chun

    2004-07-12

    Six clusters Ag(8)(micro(8)-X)[Se(2)P(OR)(2)](6)(PF(6)) (R = Et, X = Cl, 1a, X = Br, 1b; R = Pr, X = Cl, 2a, X = Br, 2b; R = (i)Pr, X = Cl, 3a, X = Br, 3b) were isolated from the reaction of [Ag(CH(3)CN)(4)](PF(6)), NH(4)[Se(2)P(OR)(2)], and Bu(4)NX in a molar ratio of 4:3:1 in CH(2)X(2). Positive FAB mass spectra show m/z peaks at 2573.2 for 1a, 2617.3 for 1b, 2740.9 for 2a, 2786.9 for 2b, 2742.3 for 3a, and 2787.0 for 3b due to respective molecular cation, (M - PF(6))(+). (31)P NMR spectra of 1a-3b display a singlet at delta 82.3, 81.5, 82.9, 81.7, 76.3, and 75.8 ppm with a set of satellites (J(PSe) = 661, 664, 652, 652, 656, and 656 Hz, respectively). The X-ray structure (1a-2b) consists of a discrete cationic cluster in which eight silver ions are linked by six diselenophosphate ligands and a central micro(8)-Cl or micro(8)-Br ion with a noncoordinating PF(6)(-) anion. The shape of the molecule is a halide-centered distorted Ag(8) cubic cluster. The dsep ligand exhibits a tetrametallic tetraconnective (micro(2), micro(2)) coordination pattern, and each caps on a square face of the cube. Each silver atom of the cube is coordinated by three selenium atoms and the central chloride or bromide ion. Additionally, molecular orbital calculations at the B3LYP level of the density functional theory have been carried out to study the Ag-micro(8)-X (X = Cl, Br) interactions for cluster cations [Ag(8)(micro(8)-X)[Se(2)P(OR)(2)](6)](+). Calculations show very weak bonding interactions exist between micro(8)-X and Ag atoms of the cube. PMID:15236560

  18. Novel chloride-centered discrete CuI8 cubic clusters containing diselenophosphate ligands. Syntheses and structures of [Cu8(mu8-Cl)[Se2P(OR)2](6)](PF6) (R = Et, Pr, iPr)1.

    PubMed

    Liu, C W; Hung, Chiu-Mine; Santra, Bidyut Kumar; Chen, Hsiu-Chih; Hsueh, Hsin-Hsueh; Wang, Ju-Chung

    2003-05-19

    Three clusters 1-3, Cu(8)(mu8-Cl)[Se(2)P(OR)(2)](6)(PF(6)) (R= Et, Pr, (i)Pr), were synthesized in high yield from the reaction of [Cu(CH(3)CN)(4)](PF(6)), NH(4)[Se(2)P(OR)(2)], and Bu(4)NCl in a molar ratio of 4:3:1 in diethyl ether. FAB mass spectra show m/z peaks at 2218.10 for 1, 2386.10 for 2, and 2387.34 for 3 which are due to molecular cations, [1-PF(6)]+, [2-PF(6)]+, and [3-PF(6)]+, respectively. (31)P NMR spectra of 1-3 display a singlet at delta 76.48, 76.73, and 69.32 ppm with satellites (J(PSe) = 652, 653, and 648 Hz), respectively. The (77)Se NMR spectra of 1-3 exhibit a doublet peak at -21.7, -16.42, and 2.3 ppm, respectively (J(SeP) = 652 Hz for 1, 653 Hz for 2, and 648 Hz for 3). The X-ray structure (1-3) consists of a discrete cationic cluster in which eight copper ions are linked by six diselenophosphate ligands and a central mu8-Cl ion with a noncoordinating PF(6)(-) anion. The shape of the molecule is a chloride-centered distorted Cu(8) cube in clusters 1 and 2 and a near perfect Cu(8) cube for cluster 3. The dsep ligand exhibits a tetrametallic tetraconnective (mu2, mu2)) coordination pattern, and each occupies a square face of the cube. Each copper atom of the cube is coordinated by three selenium atoms with a strong interaction with the central chloride ion. The observed Cu-Cl distances lie in the range 2.649-2.878 A. PMID:12739962

  19. La busqueda textual por computadora (Textual Search by Computer)

    ERIC Educational Resources Information Center

    Davison, Ned J.

    1977-01-01

    Describes the use of the computer program EDIT for textual searches to locate a certain programmed word or word root. In the examples explained here, the vocabulary search is performed on poetry and allows examination of the metaphorical and conceptual poetic atmosphere achieved through word use. (Text is in Spanish.) (CHK)

  20. On the Use of "Por" Plus Agent with "Se" Construction

    ERIC Educational Resources Information Center

    De Mello, George

    1978-01-01

    Two explanations for the role of "se" in such constructions as "Se construyen casas" are given by grammarians; one states that it is a passive interpretation ("Houses are built"), the other advocates an impersonal interpretation ("One builds houses"). Different views are presented and analyzed. (Author/NCR)

  1. Por los Ninos (For the Children): Education of Undocumented Children.

    ERIC Educational Resources Information Center

    Gonzalez, Elena R.; Team, Linda B.

    Published as a special project of Texas IMPACT and the Texas Conference of Churches, this booklet outlines legal aspects of the education of undocumented children, lists moral and practical reasons for educating them, provides reasons for changing the Texas law which prohibits use of state funds for education of children who are not legally…

  2. POR FIN (Program Organizing Related Family Instruction in the Neighborhood).

    ERIC Educational Resources Information Center

    1971

    A project was undertaken in San Antonio, Texas, to develop a recruitment approach which would be more effective than the traditional mass media approach in recruiting hard-core undereducated individuals into adult education classes. An experiment was designed to test a recruiting method which would employ a personal, face-to-face interview…

  3. [The right to avoid pregnancy] [POR, ENG translation included].

    PubMed

    1981-01-21

    Signs are finally appearing in Brazil that despite the government's hesitations and the hostility of the Catholic Church the decade of the 1980s shall bring effective changes intended to restrain population growth. Now, 4 years after its inclusion in the social program of the Geisel administration in 1977, family planning will become a reality. It is certainly about time, for at the present rate of growth the Brazilian population increases by about 6 persons per minute--about 3 million a year. At this pace, only a large scale State intervention that provides the population with information, assistance and free access to contraception may decisively reverse the trend. Figueiredo's government has decided that family planning should be introduced slowly, gradually and subtly, thus avoiding specific programs and publicity campaigns through the mass communication vehicles. In an effort to get around sharper criticism from the Church and the opposition, the government intends to mobilize catholic laypersons, priests, and nuns and, if possible, bishops in a national attempt to disseminate information on natural methods of birth control. As a 1st step, the Ministry of Health will widely distribute information on human reproduction and fecundity along with explanations of artificial contraceptive methods. Subject to the couple's decision and under medical indications, the free supply of contraceptive means to low income families shall be ensured by the government. The government will also allow sterilization. Despite its cautious approach, in actuality the government's program will in many places and circumstances be a massive inducement to contraceptive use. PMID:12337558

  4. Síndrome del Outlet Torácico: ¿Una Patología Siempre Quirúrgica? Análisis de una Serie de 31 Cirugías Realizadas por Vía Supraclavicular Serie clínica

    PubMed Central

    Socolovsky, Mariano; Di Masi, Gilda; Binaghi, Daniela; Campero, Álvaro; Páez, Miguel Domínguez; Dubrovsky, Alberto

    2014-01-01

    Introducción: El síndrome de outlet torácico es una compresión del plexo braquial que suscita polémica. Se clasifica en Outlet Torácico Verdadero o neurogénico (OTV) y Outlet Torácico Disputado o no neurogénico (OTD). El primero presenta síntomas motores en la mano, mientras que el segundo sólo síntomas sensitivos en el miembro superior. El objetivo de este trabajo es analizar los resultados obtenidos en una serie de 31 cirugías. Métodos: Se analizaron las cirugías de nervios efectuadas entre 2003-2012, tomando los diagnósticos de outlet torácico cuyo período de seguimiento post-operatorio mínimo fuera de 6 meses. Se buscaron los siguientes datos: edad, sexo, presencia de síntomas sensitivos y/o motores, clasificación, resultado de los estudios neurofisiológicos y de imágenes, resultado de la cirugía, complicaciones post-operatorias y recidivas. Resultados: Se incluyeron 31 cirugías realizadas en 30 pacientes, 9 OTV (8 mujeres) de 24.3 años, y 21 con OTD (18 mujeres) de 37.4 años de edad en promedio. Un 90% presentaron alteraciones neurofisiológicas preoperatorias, y 66,6% imagenológicas. En el intraoperatorio, el 100% de los OTV presentó una alteración anatómica relacionada con la sintomatología, hecho observado sólo en el 36.7% de los OTD operados. El 87,5% de los OTV mejoraron sensitivamente, mientras que 77,7% mejoraron la atrofia. Por el contrario, 45.4% de los OTD mejoraron permanentemente, 36.3% no tuvieron cambios, 13.6% mejoraron transitoriamente y 4.5% (un caso) empeoró. Las complicaciones post-operatorias fueron más frecuentes aunque transitorias en el grupo de OTV (3 casos sobre 9 operados, 33.3%) que en los OTD (3 casos sobre 22, un 13.6%). Conclusión: El OTV suele mayormente mejorar luego de la cirugía, igual que el OTD aunque en una proporción mucho menor. Estos hallazgos coinciden con otros reportes recientes de esta patología. PMID:25165614

  5. A Comparison Between PSRK and GERG-2004 Equation of State for Simulation of Non-Isothermal Compressible Natural Gases Mixed with Hydrogen in Pipelines / Porównanie równań stanu opracowanych według metody PSRK oraz GERG-2004 wykorzystanych do symulacji zachowania ściśliwych mieszanin gazu ziemnego i wodoru w rurociągach, w warunkach przepływów nie-izotermicznych

    NASA Astrophysics Data System (ADS)

    Uilhoorn, Frits E.

    2013-06-01

    In this work, the GERG-2004 equation of state based on a multi-fluid approximation explicit in the reduced Helmholtz energy is compared with the predictive Soave-Redlich-Kwong group contribution method. In the analysis, both equations of state are compared by simulating a non-isothermal transient flow of natural gas and mixed hydrogen-natural gas in pipelines. Besides the flow conditions also linepack-energy and energy consumption of the compressor station are computed. The gas flow is described by a set of partial differential equations resulting from the conservation of mass, momentum and energy. A pipeline section of the Yamal-Europe gas pipeline on Polish territory has been selected for the case study. W artykule dokonano porównania wyników uzyskanych przy wykorzystaniu równania stanu GERG- 2004 opartego na jawnym przybliżeniu wyników dla wielu cieczy w oparciu o zredukowaną energię Helmhotza oraz wyników uzyskanych w oparciu o metodę Soave-Redlich Kwonga. Obydwa równania stanu porównano poprzez przeprowadzenie symulacji stanów przejściowych przepływów gazu ziemnego oraz mieszanin gazu ziemnego i wodoru w rurociągach w warunkach przepływów nie-izotermicznych. Oprócz warunków przepływu, określono energię w napełnionym układzie oraz zużycie energii przez stację kompresora. Przepływ gazu opisano zbiorem równań różniczkowych cząstkowych, wyprowadzonych w oparciu o prawa zachowania masy, pędu i energii. Jako studium przypadku wybrano fragment rurociągu jamalskiego (Yamal- Europa) przebiegającego przez terytorium Polski.

  6. Colleges and Rural and Remote Communities: Challenge and Opportunity = Les colleges de collectivites rurales ou eloignees: Les defis et les perspectives d'avenir.

    ERIC Educational Resources Information Center

    Malcolmson, Lorna, Ed.

    2001-01-01

    This issue of College Canada looks at the challenges confronting Canada's rural community colleges. Topics addressed in the issue include information technology and community colleges, public policy for rural community colleges, and educational partnerships. Articles include: (1) "Gather 'Round, Let's Talk... Anchoring the Community College in…

  7. Assimilation of SMOS soil moisture into a distributed hydrological model and impacts on the water cycle variables over the Ouémé catchment in Benin

    NASA Astrophysics Data System (ADS)

    Leroux, Delphine J.; Pellarin, Thierry; Vischel, Théo; Cohard, Jean-Martial; Gascon, Tania; Gibon, François; Mialon, Arnaud; Galle, Sylvie; Peugeot, Christophe; Seguis, Luc

    2016-07-01

    Precipitation forcing is usually the main source of uncertainty in hydrology. It is of crucial importance to use accurate forcing in order to obtain a good distribution of the water throughout the basin. For real-time applications, satellite observations allow quasi-real-time precipitation monitoring like the products PERSIANN (Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks, TRMM (Tropical Rainfall Measuring Mission) or CMORPH (CPC (Climate Prediction Center) MORPHing). However, especially in West Africa, these precipitation satellite products are highly inaccurate and the water amount can vary by a factor of 2. A post-adjusted version of these products exists but is available with a 2 to 3 month delay, which is not suitable for real-time hydrologic applications. The purpose of this work is to show the possible synergy between quasi-real-time satellite precipitation and soil moisture by assimilating the latter into a hydrological model. Soil Moisture Ocean Salinity (SMOS) soil moisture is assimilated into the Distributed Hydrology Soil Vegetation Model (DHSVM) model. By adjusting the soil water content, water table depth and streamflow simulations are much improved compared to real-time precipitation without assimilation: soil moisture bias is decreased even at deeper soil layers, correlation of the water table depth is improved from 0.09-0.70 to 0.82-0.87, and the Nash coefficients of the streamflow go from negative to positive. Overall, the statistics tend to get closer to those from the reanalyzed precipitation. Soil moisture assimilation represents a fair alternative to reanalyzed rainfall products, which can take several months before being available, which could lead to a better management of available water resources and extreme events.

  8. What Feynman Could Not yet Use: The Generalised Hong-Ou-Mandel Experiment to Improve the QED Explanation of the Pauli Exclusion Principle

    ERIC Educational Resources Information Center

    Malgieri, Massimiliano; Tenni, Antonio; Onorato, Pasquale; De Ambrosis, Anna

    2016-01-01

    In this paper we present a reasoning line for introducing the Pauli exclusion principle in the context of an introductory course on quantum theory based on the sum over paths approach. We start from the argument originally introduced by Feynman in "QED: The Strange Theory of Light and Matter" and improve it by discussing with students…

  9. Heterologous expression of glutamyl-tRNA reductase gene in Rhodobacter sphaeroides O.U.001 to enhance 5-aminolevulinic acid production

    PubMed Central

    Kars, Gökhan; Alparslan, Ümmühan

    2014-01-01

    The pathways for synthesis of 5-aminolevulinic acid (5-ALA) use either succinyl-CoA and glycine (C-4 pathway), or glutamate (C-5 pathway). Although Rhodobacter sphaeroides synthesizes 5-ALA through the C-4 pathway, it also has the genes coding for the enzymes of the C-5 pathway, except for glutamyl-tRNA reductase. The glutamyl-tRNA reductase gene was cloned from Rhodospirillum rubrum and expressed in R. sphaeroides; thus, the C-5 pathway was enabled to function upon assembling all the required genes. Consequently, a new and unique bacterial strain producing more 5-ALA was developed. Biohydrogen was also produced in the same bioprocess within a biorefinery approach using sugar beet molasses as substrate. The amount of 5-ALA produced by the modified strain was 25.9 mg/g dry cell weight (DCW), whereas the wild-type strain produced 12.4 mg/g DCW. In addition, the amount of H2 generated by the modified and wild-type cells, respectively, was 0.92 L/L culture and 1.05 L/L culture. PMID:26740781

  10. Les notions floves en droit ou l'economie de l'imprecision (Fuzzy Notions in Law or the Economy of Imprecision).

    ERIC Educational Resources Information Center

    Mackaay, Ejan

    1979-01-01

    Proposes the theory that the "semantic fluidity" of legal terminology, far from being an obstacle to the carrying out of the law, is essential to the functioning of the executive, legislative, and judicial branches in a cost-effective manner. (AM)

  11. Aspects épidémiologique, clinique et anatomopathologique du mélanome CHU Yalgado Ouédraogo de Ouagadougou (Burkina Faso)

    PubMed Central

    Korsaga-Somé, Nina; Zongo, Nayi; Ouangré, Edgar; Tapsoba, Patrice; Ouédraogo, Muriel Sidnomam; Ilboudo, Léopold; Bassolet, Alban; Sanou, Maryam; Djimtibaye, Djounitana; Barro-Traoré, Fatou; Niamba, Pascal; Traoré, Adama

    2015-01-01

    Le mélanome est une tumeur maligne développée aux dépens des mélanocytes. Ses caractéristiques épidémiologiques restent peu étudiées dans les populations africaines. D'où le but de cette étude. Il s'est agit d'une étude rétrospective descriptive de janvier 2009 à décembre 2012 et prospective en 2013. Pour la partie rétrospective, nous avons inclus tous les patients atteints de mélanome confirmé par l'examen histopathologique et ayant un dossier clinique exploitable. Pour la partie prospective, nous avons inclus tous les cas de mélanomes recensés en 2013. Les variables étudiées étaient les caractéristiques sociodémographiques, anatomocliniques et thérapeutiques. Au total 19 patients étaient inclus, avec un âge médian de 53,42 ans et 10 patients de sexe féminin. La durée moyenne d’évolution de la maladie était de 3,7 ans. Les lésions étaient surtout ulcero-bourgeonnantes (13), hyperpigmentées (15), et siégeaient sur les plantes (14). Le type et acro-lentigineux était le plus fréquent (13). L'indice de Clarck a été mesuré dans 3 cas, l'indice de Breslow dans aucun cas. Les métastases étaient présentes chez 10 patients. Le traitement était surtout chirurgical. Les 11 patients inclus de manière retrospective étaient ont été perdus de vue. Un décès était noté parmi les 8 patients inclus de manière prospective. Le retard à la consultation semblait être le principal facteur de mauvais pronostic dans notre contexte. Une sensibilisation de la population et du personnel de santé sur les signes précoces de la maladie, permettrait probablement de réduire la morbidité. PMID:26113951

  12. Time series geophysical monitoring of permanganate injections and in situ chemical oxidation of PCE, OU1 area, Savage Superfund Site, Milford, NH, USA.

    PubMed

    Harte, Philip T; Smith, Thor E; Williams, John H; Degnan, James R

    2012-05-01

    In situ chemical oxidation (ISCO) treatment with sodium permanganate, an electrically conductive oxidant, provides a strong electrical signal for tracking of injectate transport using time series geophysical surveys including direct current (DC) resistivity and electromagnetic (EM) methods. Effective remediation is dependent upon placing the oxidant in close contact with the contaminated aquifer. Therefore, monitoring tools that provide enhanced tracking capability of the injectate offer considerable benefit to guide subsequent ISCO injections. Time-series geophysical surveys were performed at a superfund site in New Hampshire, USA over a one-year period to identify temporal changes in the bulk electrical conductivity of a tetrachloroethylene (PCE; also called tetrachloroethene) contaminated, glacially deposited aquifer due to the injection of sodium permanganate. The ISCO treatment involved a series of pulse injections of sodium permanganate from multiple injection wells within a contained area of the aquifer. After the initial injection, the permanganate was allowed to disperse under ambient groundwater velocities. Time series geophysical surveys identified the downward sinking and pooling of the sodium permanganate atop of the underlying till or bedrock surface caused by density-driven flow, and the limited horizontal spread of the sodium permanganate in the shallow parts of the aquifer during this injection period. When coupled with conventional monitoring, the surveys allowed for an assessment of ISCO treatment effectiveness in targeting the PCE plume and helped target areas for subsequent treatment. PMID:22459605

  13. La musique du mot et du concept, ou certains problemes de traduction poetique (The Music of Word and Concept, or Certain Problems in Poetic Translation)

    ERIC Educational Resources Information Center

    Maisonneuve, Roland

    1978-01-01

    The whole universe enters the poet's being to be eventually transformed by him/her into musical language. It is this music that the translator must reproduce. Excerpts from the poems of Patmore, Auden, Donne, Joyce and Sloate illustrate the discussion. Translation of mystical and religious poetry is given special attention. (Text is in French.)…

  14. Parlons musique et sons, ou notes a la portee...de tous (Let's Talk about Songs and Sounds, or Notes within Reach...Of Everyone).

    ERIC Educational Resources Information Center

    Zarate, Genevieve

    1984-01-01

    The language teacher is encouraged to begin use of song in the classroom by first learning himself to appreciate the musical qualities and the lyrics of the music he wants to teach and also the conditions under which music is produced and recorded. (MSE)

  15. Time series geophysical monitoring of permanganate injections and in situ chemical oxidation of PCE, OU1 area, Savage Superfund Site, Milford, NH, USA

    USGS Publications Warehouse

    Harte, Philip T.; Smith, Thor E.; Williams, John H.; Degnan, James R.

    2012-01-01

    In situ chemical oxidation (ISCO) treatment with sodium permanganate, an electrically conductive oxidant, provides a strong electrical signal for tracking of injectate transport using time series geophysical surveys including direct current (DC) resistivity and electromagnetic (EM) methods. Effective remediation is dependent upon placing the oxidant in close contact with the contaminated aquifer. Therefore, monitoring tools that provide enhanced tracking capability of the injectate offer considerable benefit to guide subsequent ISCO injections. Time-series geophysical surveys were performed at a superfund site in New Hampshire, USA over a one-year period to identify temporal changes in the bulk electrical conductivity of a tetrachloroethylene (PCE; also called tetrachloroethene) contaminated, glacially deposited aquifer due to the injection of sodium permanganate. The ISCO treatment involved a series of pulse injections of sodium permanganate from multiple injection wells within a contained area of the aquifer. After the initial injection, the permanganate was allowed to disperse under ambient groundwater velocities. Time series geophysical surveys identified the downward sinking and pooling of the sodium permanganate atop of the underlying till or bedrock surface caused by density-driven flow, and the limited horizontal spread of the sodium permanganate in the shallow parts of the aquifer during this injection period. When coupled with conventional monitoring, the surveys allowed for an assessment of ISCO treatment effectiveness in targeting the PCE plume and helped target areas for subsequent treatment.

  16. Pour Savoir ou vous en etes. Evaluez vous-meme vos connaissances (Knowing Where You Are. Evaluate Your Knowledge by Yourself).

    ERIC Educational Resources Information Center

    Aiello, Angelo; And Others

    1986-01-01

    A form is presented for language teacher self-evaluation concerning attitudes and knowledge about learning theories, general linguistics, sociolinguistics, pragmatics, discourse analysis, teaching methodology, the communicative approach, class activities, class management, instructional support, and evaluation. (MSE)

  17. Pseudo-HELLP syndrome par carence en folates et/ou en vitamine B12: à propos d'un cas

    PubMed Central

    Benali, Mechaal; Bouassida, Mahdi; Dhouib, Firas; Bouzeidi, Kaled

    2014-01-01

    Plusieurs pathologies médicales peuvent interférer avec la grossesse et mimer le tableau biologique de HELLP syndrome. L’évolution naturelle de ce syndrome est d'une particulière gravité pour la mère et le fœtus, il convient d’éliminer rapidement les autres diagnostics afin d’éviter une extraction fœtale prématurée injustifiée. Nous rapportons le cas d'une parturiente qui s'est présentée avec un tableau évocateur d'un HELLP syndrome, rapporté finalement à une carence en folates et en vitamine B12. PMID:25404961

  18. Trali ou œdème pulmonaire lésionnel aigu post-transfusionnel: à propos d'un cas avec revue de la literature

    PubMed Central

    Serghini, Issam; Nader, Youssef; Qamouss, Youssef; Zoubir, Mohamed; Lalaoui, Jaafar Salim; Boughalem, Mohamed

    2015-01-01

    L’œdème pulmonaire lésionnel aigue transfusionnel est une complication classique de la transfusion de produits sanguins labiles, responsable de 17% des décès liés à la transfusion. Il s'agit d'un syndrome de détresse respiratoire aiguë post-transfusionnel qui se présente comme un œdème pulmonaire aigu non cardiogénique survenant dans les six heures suivant la mise en oeuvre d'une transfusion sanguine. Le mot Trali utilisé pour désigner cet œdème est l'acronyme de l'anglais « transfusion-related acute lung injury »; l'incidence des TRALI déclarés en France reste faible à cause de leurs méconnaissances, faute d'une définition précise tant au plan clinique qu'au plan étiologique. La sensibilisation des médecins à l'identification des TRALI et à la déclaration, notamment en réanimation, doit être poursuivie. Des données récentes ont souligné sa relative fréquence et des études cliniques et biologiques plus attentives ont contribué à une meilleure compréhension de ses mécanismes dont deux sont bien défini: un conflit immunologique d'une part, une activation des polynucléaires neutrophiles par des facteurs lipidiquesd'autre part. Il est également admis que le Trali ne se déclenche que dans un contexte favorisant dont le substratum commun pourrait essentiellement être une leucostase préalable. Le traitement du Trali est celui des œdèmes pulmonaires lésionnels, oxygénothérapie et assistance respiratoire. Nous rapportons un cas de Trali survenu à la suite de la transfusion de 08 concentrés de globules rouges chez un jeune homme de 26 ans. PMID:26379812

  19. De la creativite a la creation ou des mythes a l'experience (From Creativity to Creation or From Myths to Experience).

    ERIC Educational Resources Information Center

    Comeau, Gilles

    1997-01-01

    Suggests that the concept of creativity has been used in an imprecise manner in education. Reviews theories of creativity in humanistic psychology, experimental psychology, and the cognitive psychological works of Piaget and Vygotsky. Argues that educators have not always distinguished between these differing views of creativity. (41 citations)…

  20. "Le Petit Prince" ou la bonne pedagogie: Une analyse semiotique des structures didactiques ("The Little Prince" or Good Teaching: A Semiotic Analysis of Didactic Structures).

    ERIC Educational Resources Information Center

    Kaminskas, Jurate

    1983-01-01

    Saint-Exupery's story, "The Little Prince," is analyzed from the point of view of the structures through which the author wishes to inspire and instruct the reader. The use of disguised didactic discourse and the manipulation of words toward this end are examined. (MSE)

  1. Une reevaluation de l'evaluation ou "Le coucou dans le nid" (A Critical Look at Evaluation Methods or "The Cuckoo in the Nest").

    ERIC Educational Resources Information Center

    Roe, Peter J.

    1981-01-01

    Discusses the fundamental principles of evaluation to show that the conventional approaches to testing have led to a situation where procedure requirements overshadow the objectives of the learning process. Advocates instruments that address realistic communication goals and states criteria based on the learner's need for continous, constructive…

  2. Mise en situation analogique, ou de la video a un niveau avance (Real Life Situations, or the Use of Visuals at the Advanced Level).

    ERIC Educational Resources Information Center

    Marino, Ingrid

    1982-01-01

    Cognitive theories normally applied to listening comprehension are applied to the use of visuals with mass media broadcasts for second language instruction: the visual image as advance organizer, as reinforcement of concrete information, and as an association with abstract information. A related study in Germany is cited and illustrated. (MSE)

  3. Performances comparées des machines à aimants et à réluctance variable. Maximisation du couple massique ou volumique

    NASA Astrophysics Data System (ADS)

    Matt, D.; Llibre, J. F.

    1995-10-01

    The subject of this article is to compare the performances of electrical machines using three different principles of functioning which are recently exploited. We consider possibilities to realise actuators with high torque and power per unit of mass for direct drive applications. The three different machines involved in the comparison are: (i) the classical synchronous structure with permanent magnets in the inductor, (ii) the vernier reluctance structure, (iii) the vernier reluctance structure with permanent magnets. To allow a good comparison, the architecture of those three motors has to be identical, particularly the shape of the main elements. L'objet de cet article est de comparer directement, pour la première fois à notre connaissance, les performances de machines électriques mettant en oeuvre trois principes de fonctionnement différents, très récemment exploités. Nous examinons les possibilités de réalisation d'actionneurs à fort couple et puissance massique élevée, pour des applications d'entraînement direct, conçus à partir soit d'une structure synchrone classique utilisant des aimants pour l'inducteur, soit d'une structure à réluctance variable vernier soit, enfin, d'un dispositif combinant l'effet de réluctance variable à l'utilisation d'aimants. Pour permettre une comparaison réellement directe, l'architecture des trois moteurs exploitant les concepts évoqués, ainsi que la forme de leurs principales pièces, seront pratiquement identiques.

  4. "O Ensaio como Forma" ou Um Ensaio acerca da Teoria Critica da Sociedade ("The Essay as Form" or An Essay about the Critical Theory of Society).

    ERIC Educational Resources Information Center

    Giordano, Rosely

    2000-01-01

    Illuminates the critical theory project, with themes permeating the theoretical constructions of Frankfurt (Germany). Debates the predominance of positivism in the production of knowledge. Speculates that "the essay as form" constitutes itself as a representation of the concept of the Enlightenment. Concludes with a dialogue between Theodor Adorno…

  5. See the World on the Internet: Tips for Parents of Young Readers--and "Surfers" = Vea el mundo por Internet: Ideas por padres de jovenes lectores y exploradores.

    ERIC Educational Resources Information Center

    Moss, Jeanette

    Regardless of whether a parent has Internet access at home, it is essential that parents learn with their children and be aware of where their travels on the Internet are taking them. Many libraries have Internet workshops for parents or children or both. In the excitement of looking at sites, children may not even realize they are reading. Many…

  6. Verification and validation interim report for portable 1,000 CFM exhauster skids POR-007/Skid E and POR-008/Skid F

    SciTech Connect

    Nelson, O.D.

    1998-07-25

    This Verification and Validation (V/V) interim report summarizes to date the results of the V/V tasks performed in each of the following life cycle phases: concept, requirements, design, implementation, test, installation and checkout, and operation and maintenance. At the end of the installation and checkout phase, the V/V final report will be issued. This interim report contains or references the following for each phase: Description of V/V tasks performed; Summary of task results; Summary of anomalies and resolution; Assessment of system quality; Recommendations.

  7. Ensenando El Espanol por Medio de Accion (Teaching Spanish through Action).

    ERIC Educational Resources Information Center

    Segal, Bertha

    A teaching guide containing 102 elementary to intermediate level Spanish lessons is presented. The lessons are based on the Total Physical Response technique of second language teaching. They follow the stages of first language acquisition: listening, speaking, and reading. Each of the ten units contains a list of new vocabulary words, individual…

  8. El Libro de la Escritura por Pinguino Tinto (The Writing Book, by Inky Penguin).

    ERIC Educational Resources Information Center

    Padgett, Ron

    Presented completely in Spanish and intended for elementary level students, this book offers 12 writing ideas and several suggestions on how students can make a book using their writing. Each writing idea is presented with a brief description (addressed to the student), several examples of student writing, and a blank page on which to write.…

  9. Producao d Dijatos por Dupla Troca de Pomeron Exclusiva no Experimento D0

    SciTech Connect

    Murilo Santana Rangel

    2008-01-01

    The first search for exclusive diffractive dijet production with invariant mass ≳ 100 GeV in Run II of the Fermilab Tevatron Collider is performed. The set of data used is the Run IIa, corresponding to an integrated luminosity of 30 pb-1 of p$\\bar{p}$ collisions at √s = 1.96 TeV taken with the D0 detector. At 95% CL, an upper limit for the ratio between the number of diffractive exclusive events and the number of non diffractive events is set to be 7.5 x 10-6, excluding two of the three models proposed to explain this production.

  10. The Escuela Moderna Movement of Francisco Ferrer: "Por la Verdad y la Justicia."

    ERIC Educational Resources Information Center

    Fidler, Geoffrey C.

    1985-01-01

    The educational theory and practice of the Escuela Modern (Modern School) movement of the Spanish educator Francisco Ferrer, born in 1850, are discussed. Two fundamental tendencies of the movement are child-centered education and education in didactic terms. (RM)