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Sample records for part ii active

  1. The subthalamic nucleus part II: modelling and simulation of activity.

    PubMed

    Heida, Tjitske; Marani, Enrico; Usunoff, Kamen G

    2008-01-01

    Part I of The Subthalamic Nucleus (volume 198) (STN) accentuates the gap between experimental animal and human information concerning subthalamic development, cytology, topography and connections.The light and electron microscopical cytology focuses on the open nucleus concept and the neuronal types present in the STN. The cytochemistry encompasses enzymes, NO, glial fibrillary acidic protein (GFAP), calcium binding proteins, and receptors (dopamine, cannabinoid, opioid, glutamate, gamma-aminobutyric acid (GABA), serotonin, cholinergic, and calcium channels). The ontogeny of the subthalamic cell cord is also reviewed. The topography concerns the rat, cat, baboon and human STN. The descriptions of the connections are also given from a historical point of view. Recent tracer studies on the rat nigro-subthalamic connection revealed contralateral projections. This monograph (Part II of the two volumes) on the subthalamic nucleus (STN) starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs and high-frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson's disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph explores the pedunculopontine-subthalamic connections and summarizes attempts to mimic neurotransmitter actions of the pedunculopontine nucleus in cell cultures and high-frequency stimulation on cultured dissociated rat subthalamic neurons. STN cell models - single- and multi-compartment models and system-level models are discussed in relation to subthalamic function and dysfunction. Parts I and II are compared. PMID:18727495

  2. Structure-activity relationships of aromatic diamines in the Ames Salmonella typhimurium assay. Part II.

    PubMed

    Kalopissis, G

    1992-09-01

    Structure-activity relationships in the case of aromatic monoamines, diversely substituted on the ring, using the mutagenic activity in the Ames test were studied in part I. This part II is based on the same general principles but applied to phenylene diamines (ortho, para and meta) diversely substituted on the ring. PMID:1381475

  3. Demonstrating Electrical Activity in Nerve and Muscle. Part II

    ERIC Educational Resources Information Center

    Robinson, D. J.

    1976-01-01

    Describes the construction of an amplifier and force transducer that can be used to demonstrate electrical activity in nerve and muscle using the gastrocnemius muscle and sciatic nerve of the frog. (MLH)

  4. Operational Control Procedures for the Activated Sludge Process, Part I - Observations, Part II - Control Tests.

    ERIC Educational Resources Information Center

    West, Alfred W.

    This is the first in a series of documents developed by the National Training and Operational Technology Center describing operational control procedures for the activated sludge process used in wastewater treatment. Part I of this document deals with physical observations which should be performed during each routine control test. Part II…

  5. Dissecting Diversity Part II

    ERIC Educational Resources Information Center

    Matthews, Frank

    2005-01-01

    This article presents "Dissecting Diversity, Part II," the conclusion of a wide-ranging two-part roundtable discussion on diversity in higher education. The participants were as follows: Lezli Baskerville, J.D., President and CEO of the National Association for Equal Opportunity (NAFEO); Dr. Gerald E. Gipp, Executive Director of the American…

  6. Surface-active phospholipid: a Pandora's box of clinical applications. Part II. Barrier and lubricating properties.

    PubMed

    Hills, B A

    2002-01-01

    In Part I, it was described how their configuration renders phospholipid molecules surface active and capable of acting at interfaces in addition to the liquid-air interface to which conventional theory has hitherto confined the study of 'surfactant' in the lung. Surface-active phospholipid (SAPL) appears no different to comparable surfactants studied in the physical sciences for the highly desirable properties that their adsorption (reversible binding) can impart to solid surfaces. In Part II, these properties are considered in sites where there is no air. Highly desirable properties include boundary lubrication (lubricity), release (antistick) and the ability of the strongly adsorbed and strongly cohesive SAPL linings to act as barriers against abrasion, corrosion and, possibly, against invasion by microorganisms. As the 'sealant', it could be the true barrier rather than the cells providing its mechanical support. Evidence is reviewed for SAPL providing the gastric mucosal barrier to acid in the stomach and preventing the digestion of Helicobacter pylori until that barrier is broken by bile in the duodenum, where H. pylori cause ulcers. The concept that SAPL provides effortless sliding of many tissues, including pleura, pericardium and peritoneum is reviewed. Particular attention is paid to the load-bearing joints, where a deficiency has been associated with osteoarthritis. The ability of the same SAPL lining to perform multiple roles is discussed in relation to the peritoneum, where it could provide the lubricant/release agent preventing surgical adhesions, while imparting semipermeability to 'the membrane' vital for peritoneal dialysis. In each site, the prophylactic use of exogenous SAPL is discussed for its potential clinical applications. PMID:12036223

  7. Rockets -- Part II.

    ERIC Educational Resources Information Center

    Leitner, Alfred

    1982-01-01

    If two rockets are identical except that one engine burns in one-tenth the time of the other (total impulse and initial fuel mass of the two engines being the same), which rocket will rise higher? Why? The answer to this question (part 1 response in v20 n6, p410, Sep 1982) is provided. (Author/JN)

  8. Profile of Administrators of Schools of Nursing, Part I: Resources for Goal Achievement. Part II: Mentoring Relationships and Influence Activities.

    ERIC Educational Resources Information Center

    Short, Judy D.

    1997-01-01

    The first part of a survey of 441 nursing school deans/directors (324 responses) identified important sources affecting goal achievement: communication skills, interpersonal skills, and creative thinking. The second part revealed that 70% had had a mentor but only 27% did while serving as dean/director. Psychosocial functions of mentoring were…

  9. Influence of embedded nanocontainers on the efficiency of active anticorrosive coatings for aluminum alloys part II: influence of nanocontainer position.

    PubMed

    Borisova, Dimitriya; Möhwald, Helmuth; Shchukin, Dmitry G

    2013-01-01

    The present work contributes to the coating design of active anticorrosive coatings for the aluminum alloy, AA2024-T3. Part II is a continuation of Part I: Influence of Nanocontainer Concentration and describes further surprising aspects of the design of nanocontainer based active anticorrosive coatings, which influence their performance. The studied coating system consists of a passive sol-gel (SiO(x)/ZrO(x)) matrix and inhibitor (2-mercaptobenzothiazole) loaded mesoporous silica nanocontainers (MBT@NCs), which are dispersed only in half of the coating volume. Varying position and concentration of MBT@NCs the synergetic effect of inhibitor amount and path length on the metal surface were analyzed, considering the balance between optimum barrier properties, active protection and adhesion. The impact of MBT@NC position on passive and active corrosion resistance was investigated by electrochemical impedance spectroscopy and scanning vibrating electrode technique. Increasing the distance between MBT@NCs and metal surface led to better barrier properties but worse active corrosion inhibition. These findings improve the understanding of the factors influencing the overall performance of active anticorrosive coatings and enable the development of a coating system with optimum anticorrosion efficiency. PMID:23237235

  10. Structured Observation of School Administrator Work Activities: Methodological Limitations and Recommendations for Research, Part II.

    ERIC Educational Resources Information Center

    Pitner, Nancy J.; Russell, James S.

    1986-01-01

    This paper critically reviews administrator work activity studies which follow the research of Henry Mintzberg. It discusses directions for future research using qualitative and quantitative methods and discourages research that relies solely on Mintzberg's structure. (Author/JAZ)

  11. The Impact of Directed Viewing-Thinking Activity on Students' Critical Thinking: Part II

    ERIC Educational Resources Information Center

    Ee, Neo Chin; Sum, Cheung Wing

    2005-01-01

    Background: Critical thinking disposition is an area that has been overlooked in various academic fields until recent years. Critical thinking occurs only when individuals possess thinking dispositions. This study explores the possibility of using directed viewing-thinking activity (DVTA) to cultivate the critical thinking dispositions of…

  12. Exploring Water Pollution. Part II

    ERIC Educational Resources Information Center

    Rillo, Thomas J.

    1975-01-01

    This is part two of a three part article related to the science activity of exploring environmental problems. Part one dealt with background information for the classroom teacher. Presented here is a suggested lesson plan on water pollution. Objectives, important concepts and instructional procedures are suggested. (EB)

  13. Activity-based cost management. Part II: Applied to a respiratory protection program.

    PubMed

    Brandt, M T; Levine, S P; Smith, D G; Ettinger, H J; Gallimore, B F

    1998-05-01

    To demonstrate the relevance of activity-based cost management (ABCM) for the occupational and environmental health community, the investigators used data generated by an ABCM model of a respiratory protection program (RPP) to develop options for solving a business problem. The RPP manager in this hypothetical but realistic business scenario is faced with a 25% budget cut and a 10% increase in demand for RPP services. The manager's dilemma is to maintain the integrity of the RPP while absorbing a significant budget cut. Various cost savings options are developed, and the assumptions under which these options operate are presented. It is emphasized that the RPP manager's primary responsibility is to assure worker health and safety by first understanding the technical issues, merits, and implications of any cost-cutting option that may be considered. It is argued that only then should the manager consider the financial merits of the possible solutions to this business problem. In this way worker health and safety, and environmental protection goals, can continue to be achieved in an economic climate of cost cutting and downsizing. PMID:9622907

  14. Analytical applications of microbial fuel cells. Part II: Toxicity, microbial activity and quantification, single analyte detection and other uses.

    PubMed

    Abrevaya, Ximena C; Sacco, Natalia J; Bonetto, Maria C; Hilding-Ohlsson, Astrid; Cortón, Eduardo

    2015-01-15

    Microbial fuel cells were rediscovered twenty years ago and now are a very active research area. The reasons behind this new activity are the relatively recent discovery of electrogenic or electroactive bacteria and the vision of two important practical applications, as wastewater treatment coupled with clean energy production and power supply systems for isolated low-power sensor devices. Although some analytical applications of MFCs were proposed earlier (as biochemical oxygen demand sensing) only lately a myriad of new uses of this technology are being presented by research groups around the world, which combine both biological-microbiological and electroanalytical expertises. This is the second part of a review of MFC applications in the area of analytical sciences. In Part I a general introduction to biological-based analytical methods including bioassays, biosensors, MFCs design, operating principles, as well as, perhaps the main and earlier presented application, the use as a BOD sensor was reviewed. In Part II, other proposed uses are presented and discussed. As other microbially based analytical systems, MFCs are satisfactory systems to measure and integrate complex parameters that are difficult or impossible to measure otherwise, such as water toxicity (where the toxic effect to aquatic organisms needed to be integrated). We explore here the methods proposed to measure toxicity, microbial metabolism, and, being of special interest to space exploration, life sensors. Also, some methods with higher specificity, proposed to detect a single analyte, are presented. Different possibilities to increase selectivity and sensitivity, by using molecular biology or other modern techniques are also discussed here. PMID:24906984

  15. Transition metal complexes of neocryptolepine analogues. Part I: Synthesis, spectroscopic characterization, and invitro anticancer activity of copper(II) complexes

    NASA Astrophysics Data System (ADS)

    Emam, Sanaa Moustafa; El Sayed, Ibrahim El Tantawy; Nassar, Nagla

    2015-03-01

    New generation of copper(II) complexes with aminoalkylaminoneocryptolepine as bidentate ligands has been synthesized and it is characterized by elemental analyses, magnetic moment, spectra (IR, UV-Vis, 1H NMR and ESR) and thermal studies. The IR data suggest the coordination modes for ligands which behave as a bidentate with copper(II) ion. Based on the elemental analysis, magnetic studies, electronic and ESR data, binuclear square planar geometry was proposed for complexes 7a, 7b, square pyramidal for 9a, 9b and octahedral for 8a, 8b, 10a, 10b. The molar conductance in DMF solution indicates that all complexes are electrolyte except 7a and 7b. The ESR spectra of solid copper(II) complexes in powder form showed an axial symmetry with 2B1g as a ground state and hyperfine structure. The thermal stability and degradation of the ligands and their metal complexes were studied employing DTA and TG methods. The metal-free ligands and their copper(II) complexes were tested for their in vitro anticancer activity against human colon carcinoma (HT-29). The results showed that the synthesized copper(II) complexes exhibited higher anticancer activity than their free ligands. Of all the studied copper(II) complexes, the bromo-substituted complex 9b exhibited high anticancer activity at low micromolar inhibitory concentrations (IC50 = 0.58 μM), compared to the other complexes and the free ligands.

  16. Standards in neurosonology. Part II

    PubMed Central

    Tomczyk, Tomasz; Luchowski, Piotr; Kozera, Grzegorz; Kaźmierski, Radosław; Stelmasiak, Zbigniew

    2016-01-01

    The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral arteries as well as a study of a specific brain structure, i.e. substantia nigra hyperechogenicity. The following aspects are included in the description of standards for each ultrasonographic method: equipment requirements, patient preparation, study technique and documentation as well as the required elements of ultrasound description. Practical criteria for the diagnosis of certain pathologies in accordance with the latest literature were also presented. Furthermore, additional comments were included in some of the sections. Part I discusses standards for the performance, documentation and description of different ultrasound methods (Duplex, Doppler). Part II and III are devoted to standards for specific clinical situations (vasospasm, monitoring after the acute stage of stroke, detection of a right-to-left shunts, confirmation of the arrest of the cerebral circulation, an assessment of the functional efficiency of circle of Willis, an assessment of the cerebrovascular vasomotor reserve as well as the measurement of substantia nigra hyperechogenicity). PMID:27104002

  17. 5-N-Substituted-2-(substituted benzenesulphonyl) glutamines as antitumor agents. Part II: synthesis, biological activity and QSAR study.

    PubMed

    Samanta, Soma; Srikanth, K; Banerjee, Suchandra; Debnath, Bikash; Gayen, Shovanlal; Jha, Tarun

    2004-03-15

    Cancer is a major killer disease throughout human history. Thus, cancer becomes a major point of interest in life science. It was proved that cancer is a nitrogen trap and tumor cells are avid glutamine consumers. The non-essential amino acid glutamine, which is a glutamic acid derivative, supplies its amide nitrogen to tumor cells in the biosynthesis of purine and pyrimidine bases of nucleic acids as well as takes part in protein synthesis. Based on these and in continuation of our composite programme of development of new potential anticancer agents through rational drug design, 17 new 5-N-Substituted-2-(substituted benzenesulphonyl) glutamines were selected for synthesis. These compounds as well as 36 earlier synthesized glutamine analogues were screened for antitumor activity using percentage inhibition of tumor cell count as the activity parameter. QSAR study was performed with 53 compounds in order to design leads with increased effectiveness for antitumor activity using both physicochemical and topological parameters. QSAR study showed that steric effect on the aromatic ring is conducive to the activity. n-butyl substitution on aliphatic side chain and atom no 12 is important for antitumor activity of glutamine analogues. PMID:15018914

  18. X-pinch. Part II

    NASA Astrophysics Data System (ADS)

    Pikuz, S. A.; Shelkovenko, T. A.; Hammer, D. A.

    2015-06-01

    Results of experimental studies of the X-pinch since its invention and implementation in 1982 at the Lebedev Physical Institute are presented. The review consists of two parts. The first part briefly outlines the history of creation and studies of X-pinches, describes the diagnostic techniques and devices developed during these studies, and presents the main results obtained in studying the physical processes occurring in the X-pinch. The second part is devoted to the results of detailed studies of the spatial, temporal, and spectral characteristics of the X-pinch hot spot—the region where the highest plasma parameters are achieved and which is a source of X-ray emission with extreme parameters. Some results of X-pinch simulations are also presented.

  19. X-pinch. Part II

    SciTech Connect

    Pikuz, S. A. Shelkovenko, T. A.; Hammer, D. A.

    2015-06-15

    Results of experimental studies of the X-pinch since its invention and implementation in 1982 at the Lebedev Physical Institute are presented. The review consists of two parts. The first part briefly outlines the history of creation and studies of X-pinches, describes the diagnostic techniques and devices developed during these studies, and presents the main results obtained in studying the physical processes occurring in the X-pinch. The second part is devoted to the results of detailed studies of the spatial, temporal, and spectral characteristics of the X-pinch hot spot—the region where the highest plasma parameters are achieved and which is a source of X-ray emission with extreme parameters. Some results of X-pinch simulations are also presented.

  20. Roots/Routes: Part II

    ERIC Educational Resources Information Center

    Swanson, Dalene M.

    2009-01-01

    This narrative acts as an articulation of a journey of many routes. Following Part I of the same research journey of rootedness/routedness, it debates the nature of transformation and transcendence beyond personal and political paradoxes informed by neoliberalism and related repressive globalizing discourses. Through a more personal, descriptive,…

  1. Local Area Networks: Part II.

    ERIC Educational Resources Information Center

    Dessy, Raymond E., Ed.

    1982-01-01

    Discusses five approaches used by industry/colleges to provide local area network (LAN) capabilities in the analytical laboratory: (1) mixed baseband bus network coupled to a star net; (2) broadband bus network; (3) ring network; (4) star network coupled to broadband net; and (5) simple multiprocessor center. Part I (September issue) focused on…

  2. Playing It Safe: Part II.

    ERIC Educational Resources Information Center

    Penman, Kenneth A.; Niccolai, Frances R.

    1985-01-01

    Explains how to prevent outdoor sports injuries; discusses related litigation and specific cases involving playing field turf, tennis, skiing, and pools; and sets out facility design and maintenance considerations and recommendations. A sidebar provides information about injury insurance available to NCAA schools. Part I of this article appeared…

  3. Outdoor Education Manual. Part II.

    ERIC Educational Resources Information Center

    Colorado City Independent School District, Texas.

    Many of the articles included in this supplement to the original "Outdoor Education Manual" were submitted by classroom teachers in Ontario. Major areas covered are photography in outdoor education, enrichment of the curriculum through use of the school yard, canoe tripping, winter activities, and forestry. Suggested activities in each of these…

  4. California Emerging Technology Forum Part II

    EPA Science Inventory

    The goal of the California Emerging Technology Forum Part II is to foster the removal of barriers for the development and use of clean technologies through the development of collaborative technology research projects on promising technologies. The collaborative technology resear...

  5. Kick, Glide, Pole! Cross-Country Skiing Fun (Part II)

    ERIC Educational Resources Information Center

    Duoos, Bridget A.

    2012-01-01

    Part I of Kick, Glide, Pole! Cross-Country Skiing Fun, which was published in last issue, discussed how to select cross-country ski equipment, dress for the activity and the biomechanics of the diagonal stride. Part II focuses on teaching the diagonal stride technique and begins with a progression of indoor activities. Incorporating this fun,…

  6. Understanding Radiation Thermometry. Part II

    NASA Technical Reports Server (NTRS)

    Risch, Timothy K.

    2015-01-01

    This document is a two-part course on the theory and practice of radiation thermometry. Radiation thermometry is the technique for determining the temperature of a surface or a volume by measuring the electromagnetic radiation it emits. This course covers the theory and practice of radiative thermometry and emphasizes the modern application of the field using commercially available electronic detectors and optical components. The course covers the historical development of the field, the fundamental physics of radiative surfaces, along with modern measurement methods and equipment.

  7. Land-Grant College Education 1910 to 1920. Part II: The Liberal Arts and Sciences Including Miscellaneous Subjects and Activities. Bulletin, 1924, No. 37

    ERIC Educational Resources Information Center

    John, Walton C., Ed.

    1925-01-01

    This survey of land-grant college education is divided into five sections, published separately as follows: Part I: History and Educational Objectives of Land-Grant College Education; Part II: The Liberal Arts and Sciences and Miscellaneous Subjects in Land-Grant Colleges; Part III: Agricultural Education in Land-Grant Colleges; Part IV:…

  8. Air Pollution Control, Part II.

    ERIC Educational Resources Information Center

    Strauss, Werner, Ed.

    This book contains five major articles in areas of current importance in air pollution control. They are written by authors who are actively participating in the areas on which they report. It is the aim of each article to completely cover theory, experimentation, and practice in the field discussed. The contents are as follows: Emissions,…

  9. Good Faith Efforts? Part II.

    ERIC Educational Resources Information Center

    Zirkel, Perry A.

    2000-01-01

    Regarding Catholic parents' suit against a suburban New York district for promoting occult activities, a federal court ruled in May 1999 that parents had failed to prove existence of the so- called Bedford program. This Solomon-like ruling also rejected First Amendment religious claims and 14th Amendment privacy claims. (MLH)

  10. Obesity. Part II--Treatment.

    PubMed Central

    Bray, G A; Gray, D S

    1988-01-01

    Conventional diets and increased exercise are the cornerstones of traditional therapy for obesity, but available data suggest that the most important component of any program is the associated behavior modification through which new ways of dealing with old problems can be learned and continually applied. This combined with very-low-calorie diets--less than 800 kcal per day--are in wide use, mostly under medical supervision. The currently available appetite-suppressing drugs are of limited efficacy, but many new ones are under active development and hold promise for the future. The most effective surgical intervention appears to be the gastric bypass operation, but this should be reserved for those who are at high risk from their obesity. Images PMID:3074556

  11. Nanocrystalline Ferrihydrite-Based Catalysts for Fischer-Tropsch Synthesis: Part II. Effects of Activation Gases on the Catalytic Performance.

    PubMed

    Rhim, Geun Bae; Hong, Seok Yong; Park, Ji Chan; Jung, Heon; Rhee, Young Woo; Chun, Dong Hyun

    2016-02-01

    Fischer-Tropsch synthesis (FTS) was carried out over nanocrystalline ferrihydrite-based (Fe9O2(OH)23) catalysts activated by different reducing agents: syngas (H2+CO), CO, and H2. The syngas activation successfully changed the ferrihydrite-based catalysts into an active and stable catalytic structure with chi-carbide (Fe2.5 C) and epsilon'-carbide (Fe2.2 C). The crystal structure of the catalysts obtained by syngas activation was similar to the structure obtained by CO activation; this similarity was probably due to the peculiar reduction behavior of the ferrihydrite-based catalysts, which exhibit much greater reducibility in CO atmosphere than in H2 atmosphere. The performance of the catalysts activated by syngas was much higher than the performance of the catalysts activated by H2 and was comparable to the performance of the catalysts activated by CO. This strongly demonstrates that the ferrihydrite-based catalysts are advantageous for industrial FTS processes because syngas can be commonly used for both activation pre-treatment and subsequent reaction. PMID:27433672

  12. Epilepsy Care in Developing Countries: Part II of II

    PubMed Central

    Birbeck, Gretchen L

    2010-01-01

    Although 80% of people with epilepsy reside in resource poor, developing countries, epilepsy care in these regions remains limited and the majority of epilepsy patients go untreated. Cost-effective, sustainable epilepsy care services, delivering first-line antiepileptic drugs through established primary health care facilities, are needed to decrease these treatment gaps. Neurologists with local experience and knowledge of the culture, who are willing to serve as educators, policy advisors, and advocates, can make a difference. This is Part II of a two-part article. Part I reviewed the burden of epilepsy and the current state of resources for treatment in developing countries, while Part II will now discuss various aspects of care in these countries. PMID:20944819

  13. The effect of in-stream activities on the Njoro River, Kenya. Part II: Microbial water quality

    NASA Astrophysics Data System (ADS)

    Yillia, Paul T.; Kreuzinger, Norbert; Mathooko, Jude M.

    The influence of periodic in-stream activities of people and livestock on the microbial water quality of the Njoro River in Kenya was monitored at two disturbed pools (Turkana Flats and Njoro Bridge) at the middle reaches. A total of 96 sets of samples were obtained from the two pools in six weeks during dry weather (January-April) in 2006. On each sampling day, two trips were made before and during in-stream activities and on each trip, two sets of samples were collected upstream and downstream of activities. This schedule was repeated four times each for Wednesday, Saturday and Sunday. Samples were processed for heterotrophic plate count bacteria (HPC), total coliform (TC), presumptive Escherichia coli and presumptive Enterococci. Additional samples were analysed for total suspended solids (TSS), turbidity, BOD 5 and ammonium-N. The microbial water quality deteriorated significant ( p < 0.05) downstream during activities at both pools. A similar trend was observed with the chemical indicators (TSS, turbidity, BOD 5 and ammonium-N). The two groups of indicators demonstrated high capacity for site segregation based on pollution levels. Pollution levels for specific days were not significantly different ( p > 0.05). This was incompatible with the variability of in-stream activities with specific days. The pooled data was explained largely by three significant principal components - recent pollution (PC1), metabolic activity (PC2) and residual pollution (PC3). It was concluded that the empirical site parity/disparity in the levels of microbial and non-microbial indicators reflected the diurnal periodicity of in-stream activities and the concomitant pollution they caused. However, microbial source tracking studies are required to distinguish faecal sources. In the meantime, measures should be undertaken to regulate in-stream activities along the stream and minimize the movement of livestock in the catchment.

  14. Use of rumination and activity monitoring for the identification of dairy cows with health disorders: Part II. Mastitis.

    PubMed

    Stangaferro, M L; Wijma, R; Caixeta, L S; Al-Abri, M A; Giordano, J O

    2016-09-01

    The objectives of this study were to evaluate (1) the performance of an automated health-monitoring system (AHMS) to identify cows with mastitis based on an alert system (health index score, HIS) that combines rumination time and physical activity; (2) the number of days between the first HIS alert and clinical diagnosis (CD) of mastitis by farm personnel; and (3) the daily rumination time, physical activity, and HIS patterns around CD. Holstein cows (n=1,121; 451 nulliparous and 670 multiparous) were fitted with a neck-mounted electronic rumination and activity monitoring tag (HR Tags, SCR Dairy, Netanya, Israel.) from at least -21 to 80 d in milk (DIM). Raw data collected in 2-h periods were summarized per 24 h as daily rumination and activity. An HIS (0 to 100 arbitrary units) was calculated daily for individual cows with an algorithm that used rumination and activity. A positive HIS outcome was defined as an HIS of <86 units during at least 1 d from -5 to 2 d after CD. Blood concentrations of nonesterified fatty acids, β-hydroxybutyrate, total calcium, and haptoglobin were also determined in a subgroup of cows (n=459) at -11±3, -4±3, 0, 3±1, 7±1, 14±1, and 28±1 DIM. The sensitivity of the HIS was 58% [95% confidence interval (CI): 49, 67] for all cases of clinical mastitis (n=123), and 55% (95% CI: 46, 64; n=114) and 89% (95% CI: 68, 100; n=9) for cases of mastitis alone or concurrent with other health disorders, respectively. Among clinical cases, sensitivity was 80.7% (95% CI: 67, 97) for cases caused by Escherichia coli (n=31) and ranged from 45 to 48% for cases caused by gram-positive bacteria (n=39; Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, Streptococcus spp., Staphylococcus spp., and Trueperella pyogenes), Staphylococcus aureus (n=11), or cases with no bacterial growth (n=25). Days between the first HIS <86 and CD were -0.6 (95% CI: -1.1, -0.2) for all cases of mastitis. Cows diagnosed with mastitis had alterations

  15. Progressive activation of degradation processes in solid oxide fuel cell stacks: Part II: Spatial distribution of the degradation

    NASA Astrophysics Data System (ADS)

    Nakajo, Arata; Mueller, Fabian; Brouwer, Jacob; Van herle, Jan; Favrat, Daniel

    2012-10-01

    Solid oxide fuel cell (SOFC) stack design must yield the highest performance, reliability and durability to achieve the lowest cost of electricity delivered to end-users. Existing modelling tools can cope with the first aim, but cannot yet provide sufficient quantitative guidance in the two others. Repeating unit models, with as degradation processes the decrease in ionic conductivity of the electrolyte, metallic interconnect corrosion, anode nickel particles coarsening and cathode chromium contamination are used to investigate their distribution, evolution and interactions in a stack. The spatial distribution of the degradation is studied for the operating conditions optimised in Part I for the highest system electrical efficiency during long-term operation under constant system power output. Current-voltage characterisations performed at different times underestimate the degradation. In the present conditions, the degradation of the cathode dominates. The lower and more uniform cathode overpotential in counter-flow configuration, combined with the beneficial effect of internal reforming on reducing the air-fuel ratio yields the highest lifetime, because it alleviates chromium contamination and interactions between the degradation processes. Increasing the operating temperature alleviates cathode chromium contamination. The beneficial decreases of the cathode overpotential exceed the detrimental higher release rate of chromium species from the metallic interconnect.

  16. Attempts at the production of more selective antitumourals. Part II. The antineoplastic activity of cyclophosphazenes linked to spermine

    NASA Astrophysics Data System (ADS)

    Sournies, François; Labarre, Jean-François; Spreafico, Federico; Filippeschi, Stefania; Quan Jin, Xing

    1986-09-01

    In an attempt to design antitumour cyclophosphazenes of improved specificity by linking them to some natural tumour finders, we studied the binding of gem-N 3P 3Az 4Cl 2 to spermine. Synthesis, NMR and mass spectra of the vectorized drug (in which two N 3P 3Az 4 active principles are linked to spermine in a DISPIROBINO configuration) are described. Results obtained with this compound in 6 murine tumour systems (L1210 and P388 leukaemias, 3LL carcinoma, M5076 reticulum cell sarcoma, B16 melanoma and line 16 mammary carcinoma), are also described and compared with results previously obtained about the targeting of gem-N 3P 3Az 4Cl 2 through 1,3-diaminopropane and 1,4-diaminobutane (putrescine).

  17. Shaping frequency response of a vibrating plate for passive and active control applications by simultaneous optimization of arrangement of additional masses and ribs. Part II: Optimization

    NASA Astrophysics Data System (ADS)

    Wrona, Stanislaw; Pawelczyk, Marek

    2016-03-01

    It was shown in Part I that an ability to shape frequency response of a vibrating plate according to precisely defined demands has a very high practical potential. It can be used to improve acoustic radiation of the plate for required frequencies or enhance acoustic isolation of noise barriers and device casings. It can be used for both passive and active control. The proposed method is based on mounting several additional ribs and masses (passive and/or active) to the plate surface at locations followed from an optimisation process. In Part I a relevant model of such structure, as a function of arrangement of the additional elements was derived and validated. The model allows calculating natural frequencies and mode-shapes of the whole structure. The aim of this companion paper, Part II, is to present the second stage of the method. This is an optimization process that results in arrangement of the elements guaranteeing desired plate frequency response, and enhancement of controllability and observability measures. For that purpose appropriate cost functions, and constraints followed from technological feasibility are defined. Then, a memetic algorithm is employed to obtain a numerical solution with parameters of the arrangement. The optimization results are initially presented for simple cases to validate the method. Then, more complex scenarios are analysed with very special demands concerning the frequency response to present the full potential of the method. Subsequently, a laboratory experiment is presented and discussed. Finally, other areas of applications of the proposed method are shown and conclusions for future research are drawn.

  18. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part 504—Fuel Price Computation (a) Introduction. This appendix provides the equations and...

  19. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part 504—Fuel Price Computation (a) Introduction. This appendix provides the equations and...

  20. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part 504—Fuel Price Computation (a) Introduction. This appendix provides the equations and...

  1. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... example fuel price and inflation indices based on the latest data appearing in the Energy...

  2. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... example fuel price and inflation indices based on the latest data appearing in the Energy...

  3. Diffuse Cystic Lung Disease. Part II.

    PubMed

    Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X

    2015-07-01

    The diffuse cystic lung diseases have a broad differential diagnosis. A wide variety of pathophysiological processes spanning the spectrum from airway obstruction to lung remodeling can lead to multifocal cyst development in the lung. Although lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are perhaps more frequently seen in the clinic, disorders such as Birt-Hogg-Dubé syndrome, lymphocytic interstitial pneumonia, follicular bronchiolitis, and light-chain deposition disease are increasingly being recognized. Obtaining an accurate diagnosis can be challenging, and management approaches are highly disease dependent. Unique imaging features, genetic tests, serum studies, and clinical features provide invaluable clues that help clinicians distinguish among the various etiologies, but biopsy is often required for definitive diagnosis. In part II of this review, we present an overview of the diffuse cystic lung diseases caused by lymphoproliferative disorders, genetic mutations, or aberrant lung development and provide an approach to aid in their diagnosis and management. PMID:25906201

  4. Improved computational model (AQUIFAS) for activated sludge, integrated fixed-film activated sludge, and moving-bed biofilm reactor systems, part II: multilayer biofilm diffusional model.

    PubMed

    Sen, Dipankar; Randall, Clifford W

    2008-07-01

    Research was undertaken to develop a diffusional model of the biofilm that can be applied in lieu of a semi-empirical model to upgrade an activated sludge system to an integrated fixed-film activated sludge (IFAS) or moving-bed biofilm reactor (MBBR) system. The model has been developed to operate with up to 12 cells (reactors) in series, with biofilm media incorporated to one or more of the zone cells, except the anaerobic zone cells. The values of the kinetic parameters for the model were measured using pilot-scale activated sludge, IFAS, and MBBR systems. The biofilm is divided into 12 layers and has a stagnant liquid layer. Diffusion and substrate utilization are calculated for each layer. The equations are solved simultaneously using a finite difference technique. The biofilm flux model is then linked to the activated sludge model. Advanced features include the ability to compute the biofilm thickness and the effect of biofilm thickness on performance. The biofilm diffusional model is also used to provide information and create a table of biofilm yields at different substrate concentrations that can be used in the semi-empirical model. PMID:18710146

  5. 40 CFR Appendix II to Part 261 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false II Appendix II to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Appendix II to Part 261...

  6. Pharmacokinetic interactions with calcium channel antagonists (Part II).

    PubMed

    Schlanz, K D; Myre, S A; Bottorff, M B

    1991-12-01

    Since calcium channel antagonists are a diverse class of drugs frequently administered in combination with other agents, the potential for clinically significant pharmacokinetic drug interactions exists. These interactions occur most frequently via altered hepatic blood flow and impaired hepatic enzyme activity. Part I of the article, which appeared in the previous issue of the Journal, dealt with interactions between calcium antagonists and marker compounds, theophylline, midazolam, lithium, doxorubicin, oral hypoglycaemics and cardiac drugs. Part II examines interactions with cyclosporin, anaesthetics, carbamazepine and cardiovascular agents. PMID:1782739

  7. 46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Pt. 153, App. II Appendix II...

  8. 46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Pt. 153, App. II Appendix II...

  9. 46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Pt. 153, App. II Appendix II...

  10. 46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Pt. 153, App. II Appendix II...

  11. 46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Pt. 153, App. II Appendix II...

  12. Division II: Commission 10: Solar Activity

    NASA Astrophysics Data System (ADS)

    van Driel-Gesztelyi, Lidia; Scrijver, Karel J.; Klimchuk, James A.; Charbonneau, Paul; Fletcher, Lyndsay; Hasan, S. Sirajul; Hudson, Hugh S.; Kusano, Kanya; Mandrini, Cristina H.; Peter, Hardi; Vršnak, Bojan; Yan, Yihua

    2015-08-01

    The Business Meeting of Commission 10 was held as part of the Business Meeting of Division II (Sun and Heliosphere), chaired by Valentin Martínez-Pillet, the President of the Division. The President of Commission 10 (C10; Solar activity), Lidia van Driel-Gesztelyi, took the chair for the business meeting of C10. She summarised the activities of C10 over the triennium and the election of the incoming OC.

  13. The search for natural bioactive compounds through a multidisciplinary approach in Bolivia. Part II. Antimalarial activity of some plants used by Mosetene indians.

    PubMed

    Muñoz, V; Sauvain, M; Bourdy, G; Callapa, J; Rojas, I; Vargas, L; Tae, A; Deharo, E

    2000-02-01

    Forty-six different species collected in the Mosetene ethnia, dwelling in the Andean Piedmont of Bolivia, were screened for antimalarial properties. Thirty-three extracts were screened for antimalarial activity in vitro on Plasmodium falciparum chloroquine resistant strain (Indo), and forty-seven extracts were evaluated in vivo on the rodent malaria P. vinckei petteri 279BY. Only two plants are specifically used in combination by the Mosetene against malaria attack (Hymenachne donacifolia and Tesseria integrifolia), but they did not display any activity in vivo at 1000 mg/kg. The in vivo most active extracts were Swietenia macrophylla bark, Trema micrantha bark and Triplaris americana bark, not all of them were used for antimalarial purposes by the Mosetene. The following extracts were moderately active: Jacaratia digitata inner bark and Momordica charantia aerial part (both traditionally used as febrifuge), Kalanchoe pinnate aerial part (used in inflammatory processes), Lunania parviflora twigs and leaves, Phyllanthus acuminatus (used as piscicide), Tynanthus schumannianus fruit (used against diarrhoea), Triumfetta semitrilobata (used as febrifuge, to alleviate kidney and gynecological pain) and finally Solanum mammosum fruit (used against scabies). We present here the results of this screening, emphazing on the in vivo antimalarial activity of the selected plants. The antimalarial in vivo activity of the selected species, in relation with their traditional Mosetene use is then discussed. PMID:10687870

  14. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use...

  15. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use...

  16. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use...

  17. 40 CFR Appendixes II-Iii to Part 264 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false II Appendixes II-III to Part 264 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Appendixes II-III...

  18. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use...

  19. Critical appraisal: dental amalgam update--part II: biological effects.

    PubMed

    Wahl, Michael J; Swift, Edward J

    2013-12-01

    Dental amalgam restorations have been controversial for over 150 years. In Part I of this Critical Appraisal, the clinical efficacy of dental amalgam was updated. Here in Part II, the biological effects of dental amalgam are addressed. PMID:24320063

  20. 30 CFR Appendix II to Subpart D of... - Appendix II to Subpart D of Part 18

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Appendix II to Subpart D of Part 18 II Appendix II to Subpart D of Part 18 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Machines Assembled With Certified...

  1. 40 CFR Appendixes I-Ii to Part 268 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268...

  2. 40 CFR Appendixes I-Ii to Part 268 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268...

  3. Talking about the Weather, Part II.

    ERIC Educational Resources Information Center

    Gibb, Allan A.

    1984-01-01

    This second part of a two-part article highlights some mathematics involved in the study of meteorology. Examples are given of the application of mathematics to the study of the atmosphere, with three problems discussed. (MNS)

  4. A Physicist for All Seasons: Part II

    NASA Astrophysics Data System (ADS)

    Oppenheimer, Frank

    2013-06-01

    The second part of this interview covers Frank Oppenheimer's move to the University of California at Berkeley and wartime work at the Westinghouse Research Laboratories in Pittsburgh, Pennsylvania, at the electromagnetic-separation plant in Oak Ridge, Tennessee, and at Los Alamos, New Mexico (1941-1945); his postwar research at Berkeley (1945-1947); his appointment at the University of Minnesota in 1947 and firing two years later after being required to testify before the House Un-American Activities Committee; his decade as a rancher in Colorado (1949-1959) and high-school science teacher toward the end of this period; his research at the University of Colorado in Boulder after 1959; his year as a Guggenheim Fellow at University College London in 1965; and his founding of the Exploratorium in San Francisco. California, in 1969. He also discusses his wartime relations with his older brother Robert and postwar events in Robert's life, including his Hearings before the Personnel Security Board of the Atomic Energy Commission in 1954.

  5. Overactive bladder - 18 years - Part II.

    PubMed

    Truzzi, Jose Carlos; Gomes, Cristiano Mendes; Bezerra, Carlos A; Plata, Ivan Mauricio; Campos, Jose; Garrido, Gustavo Luis; Almeida, Fernando G; Averbeck, Marcio Augusto; Fornari, Alexandre; Salazar, Anibal; Dell'Oro, Arturo; Cintra, Caio; Sacomani, Carlos Alberto Ricetto; Tapia, Juan Pablo; Brambila, Eduardo; Longo, Emilio Miguel; Rocha, Flavio Trigo; Coutinho, Francisco; Favre, Gabriel; Garcia, Jose Antonio; Castano, Juan; Reyes, Miguel; Leyton, Rodrigo Eugenio; Ferreira, Ruiter Silva; Duran, Sergio; Lopez, Vanda; Reges, Ricardo

    2016-01-01

    Traditionally, the treatment of overactive bladder syndrome has been based on the use of oral medications with the purpose of reestablishing the detrusor stability. The recent better understanding of the urothelial physiology fostered conceptual changes, and the oral anticholinergics - pillars of the overactive bladder pharmacotherapy - started to be not only recognized for their properties of inhibiting the detrusor contractile activity, but also their action on the bladder afference, and therefore, on the reduction of the symptoms that constitute the syndrome. Beta-adrenergic agonists, which were recently added to the list of drugs for the treatment of overactive bladder, still wait for a definitive positioning - as either a second-line therapy or an adjuvant to oral anticholinergics. Conservative treatment failure, whether due to unsatisfactory results or the presence of adverse side effects, define it as refractory overactive bladder. In this context, the intravesical injection of botulinum toxin type A emerged as an effective option for the existing gap between the primary measures and more complex procedures such as bladder augmentation. Sacral neuromodulation, described three decades ago, had its indication reinforced in this overactive bladder era. Likewise, the electric stimulation of the tibial nerve is now a minimally invasive alternative to treat those with refractory overactive bladder. The results of the systematic literature review on the oral pharmacological treatment and the treatment of refractory overactive bladder gave rise to this second part of the review article Overactive Bladder - 18 years, prepared during the 1st Latin-American Consultation on Overactive Bladder. PMID:27176185

  6. Water Pollution: Part I, Municipal Wastewaters; Part II, Industrial Wastewaters.

    ERIC Educational Resources Information Center

    Fowler, K. E. M.

    This publication is an annotated bibliography of municipal and industrial wastewater literature. This publication consists of two parts plus appendices. Part one is entitled Municipal Wastewaters and includes publications in such areas as health effects of polluted waters, federal policy and legislation, biology and chemistry of polluted water,…

  7. Influence of activated-carbon-supported transition metals on the decomposition of polychlorobiphenyls. Part II: Chemical and physical characterization and mechanistic study.

    PubMed

    Sun, Yifei; Liu, Lina; Oshita, Kazuyuki; Zeng, Xiaolan; Wang, Wei; Zhang, Yibo

    2016-09-01

    This paper studies the synergism between transition metals (TMs) and activated carbon (AC) as a catalyst support used in the catalytic decomposition of PCBs. A series of AC-supported TM catalysts was prepared according to two distinct methods: impregnation and ion exchange which were defined as LaTM-C and IRTM-C, respectively. The catalytic reactions between 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and AC-supported Fe, Ni, Cu and Zn catalysts were conducted under N2 atmosphere. Changes in the nature of the catalysts as well as the decomposition mechanism of PCB-153 are discussed. Important findings include: (i) a higher metal concentration and a better metal distribution on AC is realized using ion-exchange, despite a lower AC specific surface area, (ii) IRTM-C had better effects on the decomposition of PCB-153 than LaTM-C, (iii) the role of Ni, Cu, and Fe as electron donors in PCB dechlorination was evaluated vs. the stability of Zn, and (iv) both temperature and chemical composition of TM catalysts influenced the decomposition efficiency of PCBs. PMID:27320438

  8. Coal-fired power materials - Part II

    SciTech Connect

    Viswanathan, V.; Purgert, R.; Rawls, P.

    2008-09-15

    Part 1 discussed some general consideration in selection of alloys for advanced ultra supercritical (USC) coal-fired power plant boilers. This second part covers results reported by the US project consortium, which has extensively evaluated the steamside oxidation, fireside corrosion, and fabricability of the alloys selected for USC plants. 3 figs.

  9. Biochemical Engineering. Part II: Process Design

    ERIC Educational Resources Information Center

    Atkinson, B.

    1972-01-01

    Describes types of industrial techniques involving biochemical products, specifying the advantages and disadvantages of batch and continuous processes, and contrasting biochemical and chemical engineering. See SE 506 318 for Part I. (AL)

  10. Fire prevention on airplanes. Part II

    NASA Technical Reports Server (NTRS)

    Sabatier, J

    1929-01-01

    This part of the report presents a detailed examination of spark prevention, fire extinguishers, and fuel tank location and design. A continued program of investigations and research is also proposed.

  11. International Perspectives in Leadership Development: Part II.

    PubMed

    Bleich, Michael R

    2015-09-01

    In the second part of this two-part series, leadership development perspectives are shared from the opening of the Penn Wharton China Center in Beijing. The symposium brought national leaders from Chinese academic settings and professional organizations together with thought leaders from the United States to discuss nursing leadership across the care continuum. Highlights of demographic shifts, clinical demands, and policy decisions are presented, with an eye toward future trends in professional development. PMID:26352039

  12. Electric injury, Part II: Specific injuries.

    PubMed

    Fish, R M

    2000-01-01

    Electric injury can cause disruption of cardiac rhythm and breathing, burns, fractures, dislocations, rhabdomyolysis, eye and ear injury, oral and gastrointestinal injury, vascular damage, disseminated intravascular coagulation, peripheral and spinal cord injury, and Reflex Sympathetic Dystrophy. Secondary trauma from falls, fires, flying debris, and inhalation injury can complicate the clinical picture. Diagnostic and treatment considerations for electric injuries are described in this article, which is the second part of a three-part series on electric injuries. PMID:10645833

  13. Getting in Taped, Part I and Part II

    ERIC Educational Resources Information Center

    Cundy, H. M.; Higgins, J.

    1971-01-01

    This article is in two parts: discussion of mathematical concepts involved in converting the reading from the tape-recorder counter which counts the turns of the run-off spool to that from the counter which counts turns of the take-up spool; calculating the length of tape run off when given the reading from the tape-recorder counter of the run-off…

  14. 46 CFR Table II to Part 150 - Grouping of Cargoes

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... affecting Table II to part 150, see the List of CFR Sections Affected, which appears in the Finding Aids... potential compatibility problems, this commodity is not assigned to a specific group in Figure 1 to 46 CFR part 150 (Compatibility Chart). 2 See Appendix I to 46 CFR part 150 (Exceptions to the Chart)....

  15. 46 CFR Table II to Part 150 - Grouping of Cargoes

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... affecting Table II to part 150, see the List of CFR Sections Affected, which appears in the Finding Aids... potential compatibility problems, this commodity is not assigned to a specific group in Figure 1 to 46 CFR part 150 (Compatibility Chart). 2 See Appendix I to 46 CFR part 150 (Exceptions to the Chart)....

  16. Moroccan Arabic Intermediate Reader, Part II.

    ERIC Educational Resources Information Center

    Alami, Wali A.; Hodge, Carlton T., Ed.

    The first section of this companion volume to "Moroccan Arabic Intermediate Reader, Part I" (AL 002 041) presents the Arabic script version of the pre-drills in Lessons IA-IIB in that volume. The second and major section comprises 20 lessons consisting of pre-drills, texts, notes, and questions. All material in this volume appears in Arabic script…

  17. A Fundamental Breakdown. Part II: Manipulative Skills

    ERIC Educational Resources Information Center

    Townsend, J. Scott; Mohr, Derek J.

    2005-01-01

    In the May, 2005, issue of "TEPE," the "Research to Practice" section initiated a two-part series focused on assessing fundamental locomotor and manipulative skills. The series was generated in response to research by Pappa, Evanggelinou, & Karabourniotis (2005), recommending that curricular programming in physical education at the elementary…

  18. Searching LEXIS and WESTLAW: Part II.

    ERIC Educational Resources Information Center

    Franklin, Carl

    1986-01-01

    This second of a three-part series compares search features (i.e., truncation symbols, boolean operators, proximity operators, phrase searching, save searches) of two databases providing legal information. Search tips concerning charges and effective searching and tables listing functions of commands and proximity operators for both databases are…

  19. The Metis Nation--Part Two II.

    ERIC Educational Resources Information Center

    Dorian, John

    1978-01-01

    This article deals with historical events involving the Metis people from the time Manitoba entered the Confederation to the conclusion of the 1885 battle at Fish Creek near Batoche, Saskatchewan. Part I is in the Summer, 1978 issue of the Northian. (Author/RTS)

  20. Inquiry and Living History, Part II

    ERIC Educational Resources Information Center

    Coatney, Sharon; Smalley, Rachel

    2006-01-01

    In the first part of this article, the authors introduced the living history program. This yearly, weeklong program features living portrayals of famous people, which becomes a catalyst for teaching curricular standards, as well as providing the spark for inquiry. Successful implementation of this program requires providing teachers with…

  1. Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part II: Future compounds against influenza virus.

    PubMed

    Gasparini, R; Amicizia, D; Lai, P L; Bragazzi, N L; Panatto, D

    2014-12-01

    In the first part of this overview, we described the life cycle of the influenza virus and the pharmacological action of the currently available drugs. This second part provides an overview of the molecular mechanisms and targets of still-experimental drugs for the treatment and management of influenza. Briefly, we can distinguish between compounds with anti-influenza activity that target influenza virus proteins or genes, and molecules that target host components that are essential for viral replication and propagation. These latter compounds have been developed quite recently. Among the first group, we will focus especially on hemagglutinin, M2 channel and neuraminidase inhibitors. The second group of compounds may pave the way for personalized treatment and influenza management. Combination therapies are also discussed. In recent decades, few antiviral molecules against influenza virus infections have been available; this has conditioned their use during human and animal outbreaks. Indeed, during seasonal and pandemic outbreaks, antiviral drugs have usually been administered in mono-therapy and, sometimes, in an uncontrolled manner to farm animals. This has led to the emergence of viral strains displaying resistance, especially to compounds of the amantadane family. For this reason, it is particularly important to develop new antiviral drugs against influenza viruses. Indeed, although vaccination is the most powerful means of mitigating the effects of influenza epidemics, antiviral drugs can be very useful, particularly in delaying the spread of new pandemic viruses, thereby enabling manufacturers to prepare large quantities of pandemic vaccine. In addition, antiviral drugs are particularly valuable in complicated cases of influenza, especially in hospitalized patients. To write this overview, we mined various databases, including Embase, PubChem, DrugBank and Chemical Abstracts Service, and patent repositories. PMID:26137785

  2. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Temperature Schedules II Appendix II... to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use...

  3. 40 CFR Appendix II to Part 265 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false II Appendix II to Part 265 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES...

  4. Treatment of superficial mycoses: review - part II*

    PubMed Central

    Dias, Maria Fernanda Reis Gavazzoni; Bernardes-Filho, Fred; Quaresma-Santos, Maria Victória Pinto; Amorim, Adriana Gutstein da Fonseca; Schechtman, Regina Casz; Azulay, David Rubem

    2013-01-01

    Superficial fungal infections of the hair, skin and nails are a major cause of morbidity in the world. Choosing the right treatment is not always simple because of the possibility of drug interactions and side effects. The first part of the article discusses the main treatments for superficial mycoses - keratophytoses, dermatophytosis, candidiasis, with a practical approach to the most commonly-used topical and systemic drugs , referring also to their dosage and duration of use. Promising new, antifungal therapeutic alternatives are also highlighted, as well as available options on the Brazilian and world markets. PMID:24474103

  5. Short history of PACS (Part II: Europe).

    PubMed

    Lemke, Heinz U

    2011-05-01

    Although the concept of picture archiving and communications systems (PACS) was developed in Europe during the latter part of the 1970s, no working system was completed at that time. The first PACS implementations took place in the United States in the early 1980s, e.g. at Pennsylvania University, UCLA, and Kansas City University. Some more or less successful PACS developments also took place in Europe in the 1980s, particularly in the Netherlands, Belgium, Austria, the United Kingdom, France, Italy, Scandinavia, and Germany. Most systems could be characterized by their focus on a single department, such as radiology or nuclear medicine. European hospital-wide PACS with high visibility evolved in the early 1990s in London (Hammersmith Hospital) and Vienna (SMZO). These were followed during the latter part of the 1990s by approximately 10-20 PACS installations in each of the major industrialized countries of Europe. Wide-area PACS covering several health care institutions in a region are now in the process of being implemented in a number of European countries. Because of limitations of space some countries, for example, Denmark, Finland, Spain, Greece, as well as Eastern European countries, etc. could not be appropriately represented in this paper. PMID:21466932

  6. [Seafood poisonings. Part II. Fish poisonings].

    PubMed

    Ciszowski, Krzysztof; Mietka-Ciszowska, Aneta

    2012-01-01

    Fish plays a significant role in human life, mainly as part of a balanced healthy diet and a good source of many of nutrients. However, contact with fish may be harmful or even life-threatening to man. Toxic effects, that fish exerts toward men (ichthyotoxism), result from envenomations by poison. ous fish equipped in venom apparatus (ichthyoacanthotoxism), direct contact with venom produced by skin glandules (ichthyocrinotoxism), or consuming fish containing toxins for nutritional purposes (ichthyosarcotoxism). In the present review, different fish-borne food poisonings are presented including their etiology, pathogenesis, symptomatology and treatment. In fact, the majority of fish poisonings are intoxications with toxins primary produced by bacteria, cyanobacteria and algae. These are consumed and accumulated in the food chain by herbivorous and predatory fish, that in turn may be a cause of poisonings in humans. PMID:23243919

  7. The sociogeometry of inequality: Part II

    NASA Astrophysics Data System (ADS)

    Eliazar, Iddo

    2015-05-01

    The study of socioeconomic inequality is of prime economic and social importance, and the key quantitative gauges of socioeconomic inequality are Lorenz curves and inequality indices - the most notable of the latter being the popular Gini index. In this series of papers we present a sociogeometric framework to the study of socioeconomic inequality. In this part we focus on the gap between the rich and the poor, which is quantified by gauges termed disparity curves. We shift from disparity curves to disparity sets, define inequality indices in terms of disparity sets, and introduce and explore a collection of distance-based and width-based inequality indices stemming from the geometry of disparity sets. We conclude with mean-absolute-deviation (MAD) representations of the inequality indices established in this series of papers, and with a comparison of these indices to the popular Gini index.

  8. Has the tsunami arrived? Part II.

    PubMed

    Halverson, Dean; Glowac, Wayne

    2009-01-01

    Healthcare is an industry in the midst of significant change. After years of double-digit cost increases, the system has reached a tipping point. Where once only employers were heard crying out for change, the call is now coming from all levels of American society. The voice that is most important to effect change is the newest--that of the consumer. In part two of our overview of the healthcare tsunami, we hope to offer you some insights and practical ideas on how to improve the return on investment of your marketing. We believe those who work to understand the new market forces and react with insight will not just survive during the tsunami, they will thrive. PMID:19663358

  9. Biosimilars in Dermatology: Current Situation (Part II).

    PubMed

    Puig, L; Carretero, G; Daudén, E; Ferrándiz, C; Marrón, S E; Martorell, A; Pérez-Suárez, B; Rodriguez-Cerdeira, C; Ruiz-Villaverde, R; Sánchez-Carazo, J L; Velasco, M

    2015-09-01

    The first biosimilar version of a biologic agent used to treat psoriasis (infliximab) entered the Spanish market on February 16 of this year, and more biosimilars can be expected to follow in the coming months and years. Logically, this new situation will have economic repercussions and alter prescribing patterns among dermatologists. In this second part of the review, we will look at several somewhat contentious issues, such as the extrapolation of indications, interchangeability, and automatic substitution. We will also review the biosimilars with indications for psoriasis currently in the clinical development pipeline and assess their potential to offer comparable efficacy and safety to the reference product while contributing to the sustainability of the public health care system. PMID:26049964

  10. DICOM: key concepts--part II.

    PubMed

    Kabachinski, Jeff

    2005-01-01

    The objective of these two installments of IT World was to give a general overview of DICOM and to take a look at different parts of the standard to get a sense of its main themes. We found that the standard provides a common reference for all developers but does not impose a single type of implementation. This allows for innovation. The standard is also built for flexibility, able to adapt to new modalities that have a need to communicate. The speedy acceptance of DICOM by the medical imaging industry is opening new possibilities for healthcare organizations to increase the quality while decreasing the cost of patient care. All of the DICOM networked supporting medical equipment as well as the organization's computer systems made by multiple original equipment manufacturers and located at one site or many sites can communicate by means of DICOM. This gives us the opportunity for medical images to be captured and communicated quicker. The result enables physicians to make diagnoses and treatment decisions sooner. It's all good stuff and even more reason why we should endeavor to understand the basics of DICOM. DICOM is here to stay! PMID:16111406

  11. Calculus of Elementary Functions, Part II. Student Text. Revised Edition.

    ERIC Educational Resources Information Center

    Herriot, Sarah T.; And Others

    This course is intended for students who have a thorough knowledge of college preparatory mathematics, including algebra, axiomatic geometry, trigonometry, and analytic geometry. This text, Part II, contains material designed to follow Part I. Chapters included in this text are: (6) Derivatives of Exponential and Related Functions; (7) Area and…

  12. Correctional Training. Institution Familiarization. Part II: The Training Program.

    ERIC Educational Resources Information Center

    Bureau of Prisons (Dept. of Justice), Washington, DC.

    Designed to assist training coordinators in the initial institution familiarization training for new employees in correctional institutions, this manual consists of two documents: a training coordinator's guide (Part I - CE 017 285) and this document, the training program (Part II). Four training areas are treated: (1) an introduction consisting…

  13. Application of ultrasound in periodontics: Part II

    PubMed Central

    Bains, Vivek K.; Mohan, Ranjana; Bains, Rhythm

    2008-01-01

    Ultrasound offers great potential in development of a noninvasive periodontal assessment tool that would offer great yield real time information, regarding clinical features such as pocket depth, attachment level, tissue thickness, histological change, calculus, bone morphology, as well as evaluation of tooth structure for fracture cracks. In therapeutics, ultrasonic instrumentation is proven effective and efficient in treating periodontal disease. When used properly, ultrasound-based instrument is kind to the soft tissues, require less healing time, and are less tiring for the operator. Microultrasonic instruments have been developed with the aim of improving root-surface debridement. The dye/paper method of mapping ultrasound fields demonstrated cavitational activity in an ultrasonic cleaning bath. Piezosurgery resulted in more favorable osseous repair and remodeling in comparison with carbide and diamond burs. The effect of ultrasound is not limited to fracture healing, but that bone healing after osteotomy or osteodistraction could be stimulated as well. PMID:20142946

  14. Minimizing Glovebox Glove Breaches: PART II.

    SciTech Connect

    Cournoyer, M. E.; Andrade, R.M.; Taylor, D. J.; Stimmel, J. J.; Zaelke, R. L.; Balkey, J. J.

    2005-01-01

    As a matter of good business practices, a team of glovebox experts from Los Alamos National Laboratory (LANL) has been assembled to proactively investigate processes and procedures that minimize unplanned breaches in the glovebox, e.g., glove failures. A major part of this effort involves the review of glovebox glove failures that have occurred at the Plutonium Facility and at the Chemical and Metallurgy Research Facility. Information dating back to 1993 has been compiled from formal records. This data has been combined with information obtained from a baseline inventory of about 9,000 glovebox gloves. The key attributes tracked include those related to location, the glovebox glove, type and location of breaches, the worker, and the consequences resulting from breaches. This glovebox glove failure analysis yielded results in the areas of the ease of collecting this type of data, the causes of most glove failures that have occurred, the effectiveness of current controls, and recommendations to improve hazard control systems. As expected, a significant number of breaches involve high-risk operations such as grinding, hammering, using sharps (especially screwdrivers), and assembling equipment. Surprisingly, tasks such as the movement of equipment and material between gloveboxes and the opening of cans are also major contributions of breaches. Almost half the gloves fail within a year of their install date. The greatest consequence for over 90% of glovebox glove failures is alpha contamination of protective clothing. Personnel self-monitoring at the gloveboxes continues to be the most effective way of detecting glovebox glove failures. Glove failures from these tasks can be reduced through changes in procedures and the design of remote-handling apparatus. The Nuclear Materials Technology Division management uses this information to improve hazard control systems to reduce the number of unplanned breaches in the glovebox further. As a result, excursions of contaminants

  15. 40 CFR Appendix II to Part 257 - Appendix II to Part 257

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CRITERIA FOR CLASSIFICATION OF SOLID WASTE DISPOSAL FACILITIES AND PRACTICES Pt. 257, App. II Appendix II... aerated pile or windrow composting methods, the solid waste is maintained at minimum operating conditions... methods or operating conditions may be acceptable if pathogens and vector attraction of the...

  16. Complement System Part II: Role in Immunity

    PubMed Central

    Merle, Nicolas S.; Noe, Remi; Halbwachs-Mecarelli, Lise; Fremeaux-Bacchi, Veronique; Roumenina, Lubka T.

    2015-01-01

    The complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it is well accepted that complement is a complex innate immune surveillance system, playing a key role in host homeostasis, inflammation, and in the defense against pathogens. This review discusses recent advances in the understanding of the role of complement in physiology and pathology. It starts with a description of complement contribution to the normal physiology (homeostasis) of a healthy organism, including the silent clearance of apoptotic cells and maintenance of cell survival. In pathology, complement can be a friend or a foe. It acts as a friend in the defense against pathogens, by inducing opsonization and a direct killing by C5b–9 membrane attack complex and by triggering inflammatory responses with the anaphylatoxins C3a and C5a. Opsonization plays also a major role in the mounting of an adaptive immune response, involving antigen presenting cells, T-, and B-lymphocytes. Nevertheless, it can be also an enemy, when pathogens hijack complement regulators to protect themselves from the immune system. Inadequate complement activation becomes a disease cause, as in atypical hemolytic uremic syndrome, C3 glomerulopathies, and systemic lupus erythematosus. Age-related macular degeneration and cancer will be described as examples showing that complement contributes to a large variety of conditions, far exceeding the classical examples of diseases associated with complement deficiencies. Finally, we discuss complement as a therapeutic target. PMID:26074922

  17. 49 CFR Appendix A-Ii to Part 541 - Lines With Antitheft Devices Which Are Exempted in-Part From the Parts-Marking Requirements of...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 A Appendix A-II... STANDARD Pt. 541, App. A-II Appendix A-II to Part 541—Lines With Antitheft Devices Which Are Exempted in-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543...

  18. Twitter as a Potential Disaster Risk Reduction Tool. Part II: Descriptive Analysis of Identified Twitter Activity during the 2013 Hattiesburg F4 Tornado

    PubMed Central

    Cooper, Guy Paul; Yeager, Violet; Burkle, Frederick M.; Subbarao, Italo

    2015-01-01

    Background: This article describes a novel triangulation methodological approach for identifying twitter activity of regional active twitter users during the 2013 Hattiesburg EF-4 Tornado. Methodology: A data extraction and geographically centered filtration approach was utilized to generate Twitter data for 48 hrs pre- and post-Tornado. The data was further validated using six sigma approach utilizing GPS data. Results: The regional analysis revealed a total of 81,441 tweets, 10,646 Twitter users, 27,309 retweets and 2637 tweets with GPS coordinates. Conclusions: Twitter tweet activity increased 5 fold during the response to the Hattiesburg Tornado.  Retweeting activity increased 2.2 fold. Tweets with a hashtag increased 1.4 fold. Twitter was an effective disaster risk reduction tool for the Hattiesburg EF-4 Tornado 2013.  PMID:26203396

  19. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    ScienceCinema

    None

    2011-10-06

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  20. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    SciTech Connect

    2010-12-17

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  1. Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part II: experimental studies with Aspidosperma ramiflorum in vivo and in vitro

    PubMed Central

    Aguiar, Anna CC; Cunha, Ananda C; Ceravolo, Isabela Penna; Gonçalves, Regina A Correia; Oliveira, Arildo JB; Krettli, Antoniana Ursine

    2015-01-01

    Several species of Aspidosperma plants are used to treat diseases in the tropics, including Aspidosperma ramiflorum, which acts against leishmaniasis, an activity that is experimentally confirmed. The species, known as guatambu-yellow, yellow peroba, coffee-peroba andmatiambu, grows in the Atlantic Forest of Brazil in the South to the Southeast regions. Through a guided biofractionation of A. ramiflorum extracts, the plant activity against Plasmodium falciparum was evaluated in vitro for toxicity towards human hepatoma G2 cells, normal monkey kidney cells and nonimmortalised human monocytes isolated from peripheral blood. Six of the seven extracts tested were active at low doses (half-maximal drug inhibitory concentration < 3.8 µg/mL); the aqueous extract was inactive. Overall, the plant extracts and the purified compounds displayed low toxicity in vitro. A nonsoluble extract fraction and one purified alkaloid isositsirikine (compound 5) displayed high selectivity indexes (SI) (= 56 and 113, respectively), whereas compounds 2 and 3 were toxic (SI < 10). The structure, activity and low toxicity of isositsirikine in vitro are described here for the first time in A. ramiflorum, but only the neutral and precipitate plant fractions were tested for activity, which caused up to 53% parasitaemia inhibition of Plasmodium berghei in mice with blood-induced malaria. This plant species is likely to be useful in the further development of an antimalarial drug, but its pharmacological evaluation is still required. PMID:26560981

  2. Controlling Salmonella infection in weanling pigs through water delivery of direct-fed microbials or organic acids: Part II. Effects on intestinal histology and active nutrient transport

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this study was to evaluate the effects of water-delivered direct-fed microbials (DFM) or organic acids on intestinal morphology and active nutrient absorption in weanling pigs following deliberate Salmonella infection. Pigs (n = 88) were weaned at 19 ± 2 d of age and assigned to one...

  3. Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy

    PubMed Central

    Smolen, Josef S; Weinblatt, Michael E; Sheng, Shihong; Zhuang, Yanli; Hsu, Benjamin

    2014-01-01

    Objectives The safety and efficacy of sirukumab, an anti-interleukin-6 (IL-6) monoclonal antibody, were evaluated in a 2-part, placebo-controlled phase II study of patients with active rheumatoid arthritis (RA) despite methotrexate therapy. Methods In Part A (proof-of-concept), 36 patients were randomised to placebo or sirukumab 100 mg every 2 weeks (q2w) through week 10, with crossover treatment during weeks 12–22. In Part B (dose finding), 151 patients were randomised to sirukumab (100 mg q2w, 100 mg q4w, 50 mg q4w, or 25 mg q4w) through week 24, or placebo through week 10 with crossover to sirukumab 100 mg q2w (weeks 12–24). The proportion of patients with an American College of Rheumatology 50 (ACR50) response and the change from baseline in the 28-joint count disease activity score using C-reactive protein (DAS28-CRP) were determined. Safety was evaluated through week 38 in both parts. Results The primary endpoint (ACR50 at week 12 in Part B) was achieved only with sirukumab 100 mg q2w versus placebo (26.7% vs 3.3%; p=0.026). Greater improvements in mean DAS28-CRP at week 12 were observed with sirukumab 100 mg q2w versus placebo in Parts A (2.1 vs 0.6, p<0.001) and B (2.2 vs 1.1; p<0.001). The incidence of adverse events (AEs) was similar for sirukumab-treated and placebo-treated patients through week 12 in Part A (70.6% and 63.2%, respectively) and B (67.8% and 66.7%, respectively). Infections were the most common type of AE; one death occurred (Part B, sirukumab 100 mg q2w, brain aneurysm). Conclusions Sirukumab-treated patients experienced improvements in the signs/symptoms of RA. Safety results through 38 weeks were consistent with other IL-6 inhibitors. Trial registration number NCT00718718. PMID:24699939

  4. Recent Economic Perspectives on Political Economy, Part II*

    PubMed Central

    Dewan, Torun; Shepsle, Kenneth A.

    2013-01-01

    In recent years some of the best theoretical work on the political economy of political institutions and processes has begun surfacing outside the political science mainstream in high quality economics journals. This two-part paper surveys these contributions from a recent five-year period. In Part I, the focus is on elections, voting and information aggregation, followed by treatments of parties, candidates, and coalitions. In Part II, papers on economic performance and redistribution, constitutional design, and incentives, institutions, and the quality of political elites are discussed. Part II concludes with a discussion of the methodological bases common to economics and political science, the way economists have used political science research, and some new themes and arbitrage opportunities. PMID:23606754

  5. Acute dental pain, Part II: Diagnosis and emergency treatment.

    PubMed

    Antonelli, J R

    1990-09-01

    Part II of this two-part series differentiates and explores endodontic-related emergencies with reversible and irreversible pulpitis. Indications and contra-indications for vital pulp therapy are explained, and treatment is outlined. The inflammatory process involved in irreversible pulpal disease is summarized, and the clinical signs, symptoms, and treatment of irreversible pulpitis (with and without acute periradicular involvement, with pulp necrosis, and acute periradicular abscess with and without cellulitis) are discussed. PMID:2097056

  6. Influence of slag chemistry on the hydration of alkali-activated blast-furnace slag - Part II: Effect of Al{sub 2}O{sub 3}

    SciTech Connect

    Ben Haha, M.; Lothenbach, B. Le Saout, G.; Winnefeld, F.

    2012-01-15

    The hydration and microstructural evolution of three alkali activated slags (AAS) with Al{sub 2}O{sub 3} contents between 7 and 17% wt.% have been investigated. The slags were hydrated in the presence of two different alkaline activators, NaOH and Na{sub 2}SiO{sub 3}{center_dot}5H{sub 2}O. The formation of C(-A)-S-H and hydrotalcite was observed in all samples by X-ray diffraction, thermal analysis and scanning electron microscopy. Higher Al{sub 2}O{sub 3} content of the slag decreased the Mg/Al ratio of hydrotalcite, increased the Al incorporation in the C(-A)-S-H and led to the formation of straetlingite. Increasing Al{sub 2}O{sub 3} content of the slag slowed down the early hydration and a lower compressive strength during the first days was observed. At 28 days and longer, no significant effects of slag Al{sub 2}O{sub 3} content on the degree of hydration, the volume of the hydrates, the coarse porosity or on the compressive strengths were observed.

  7. GUIDE FOR TEACHING ENGLISH AS A SECOND LANGUAGE TO ELEMENTARY SCHOOL PUPILS. LEVEL II, PART 2.

    ERIC Educational Resources Information Center

    WILSON, ROBERT; AND OTHERS

    THIS VOLUME COMPRISES LESSONS 56-115 OF THE SECOND LEVEL OF "TEACHING ENGLISH EARLY." FOLLOWING THE SAME FORMAT AS LEVEL II, PART 1, THE APPROACH IS STILL ORAL-AURAL, EMPHASIZING CLASSROOM ACTIVITIES AND "ACTING-OUT" WITH PUPPETS. SOMEWHAT MORE EMPHASIS IS GIVEN TO "FREE DIALOG" AND A GREATER VARIETY OF ACTIVITIES. SEE RELATED DOCUMENTS AL 001…

  8. Ethical Research Practices: Collaborative Action Research, Part II

    ERIC Educational Resources Information Center

    Calvin, Chris

    2004-01-01

    This is part II of a case study involving a large federally funded technology grant program implemented across several central Texas school districts and was followed by the researcher-participant at the university level as well as one of the campus sites. Many ethical research questions were raised during this study such as the use of participant…

  9. Predictors of Performance on National Board Examinations Part II.

    ERIC Educational Resources Information Center

    Beard, Michael W.

    1984-01-01

    In an investigation of the predictors of success on the dental National Board Examinations Part II, three studies were undertaken to test (1) the factual validity of a mock examination, (2) the usefulness of the mock examination as a predictor of board examination success, and (3) whether the third cross-validated the previous findings. (MSE)

  10. Guide to the Archives of International Organizations. Part II.

    ERIC Educational Resources Information Center

    Walne, Peter, Comp.

    This compilation forms Part II of the guide according to the plan conceived by a working party of the Section of Archivists of International Organisations of the International Council on Archives in 1974-1975. The directory provides access to national and other archive and manuscript repositories that maintain the archives of international…

  11. 46 CFR Table II to Part 150 - Grouping of Cargoes

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... citations affecting Table II to part 150, see the List of CFR Sections Affected, which appears in the... peroxide solutions 1 Lactic acid 2 Long chain alkaryl sulfonic acid (C16-C60) 2 Magnesium chloride solution...-Dimethyldodecylamine Di-n-propylamine Diphenylamine, reaction product with 2,2,4-Trimethylpentene...

  12. 46 CFR Table II to Part 150 - Grouping of Cargoes

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... citations affecting Table II to part 150, see the List of CFR Sections Affected, which appears in the... peroxide solutions 1 Lactic acid 2 Long chain alkaryl sulfonic acid (C16-C60) 2 Magnesium chloride solution...-Dimethyldodecylamine Di-n-propylamine Diphenylamine, reaction product with 2,2,4-Trimethylpentene...

  13. 46 CFR Table II to Part 150 - Grouping of Cargoes

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... II to part 150, see the List of CFR Sections Affected, which appears in the Finding Aids section of... peroxide solutions 1 Lactic acid 2 Long chain alkaryl sulfonic acid (C16-C60) 2 Magnesium chloride solution...-Dimethyldodecylamine Di-n-propylamine Diphenylamine, reaction product with 2,2,4-Trimethylpentene...

  14. Zeolite scaffolds for cultures of human breast cancer cells. Part II: Effect of pure and hybrid zeolite membranes on neoplastic and metastatic activity control.

    PubMed

    Tavolaro, Palmira; Martino, Guglielmo; Andò, Sebastiano; Tavolaro, Adalgisa

    2016-11-01

    This work is focused on the response of two invasive phenotypes of human breast cancer cells, MCF-7 and MDA-MB-231, grown on synthesized zeolite scaffolds in order to study the influence of those biomaterials in controlled conditions with and without anti-tumoral drug treatments. Our research was directed to the use of doxorubicin (DOX) and bergapten (5-MOP). The former is broadly considered the most active single agent available for the treatment of breast cancer, the second is a natural psoralen with an apoptotic effect. The results indicate that both drugs inhibit the cell viability of all cell lines grown on all zeolite scaffolds and that all Pure Zeolite Membranes are more responsive with respect to all Mixed Matrix Membranes. Moreover, the results after treatment with DOX at a concentration of 7.4μM for 24h, show that the expression of the matrix metalloproteinases (MMP-2 and MMP-9) is greatly reduced in both cell lines, especially in those adherent on Pure Zeolite Scaffolds. PMID:27524044

  15. Changes in waste stabilisation pond performance resulting from the retrofit of activated sludge treatment upstream: part II--Management and operating issues.

    PubMed

    Sweeney, D G; O'Brien, M J; Cromar, N J; Fallowfield, H J

    2005-01-01

    Bolivar Wastewater Treatment Plant (WWTP) was originally commissioned with trickling filter secondary treatment, followed by waste stabilisation pond (WSP) treatment and marine discharge. In 1999, a dissolved air flotation/filtration (DAFF) plant was commissioned to treat a portion of the WSP effluent for horticultural reuse. In 2001, the trickling filters were replaced with activated sludge treatment. A shift in WSP ecology became evident soon after this time, characterised by a statistically significant reduction in algal counts in the pond effluent, and increased variability in algal counts and occasional population crashes in the ponds. While the photosynthetic capacity of the WSPs has been reduced, the concomitant reduction in organic loading has meant that the WSPs have not become overloaded. As a result of the improvement in water quality leaving the ponds, significant cost savings and improved product water quality have been realised in the subsequent DAFF treatment stage. A number of operating issues have arisen from the change, however, including the re-emergence of a midge fly nuisance at the site. Control of midge flies using chemical spraying has negated the cost savings realised in the DAFF treatment stage. While biomanipulation of the WSP may provide a less aggressive method of midge control, this case demonstrates the difficulty of predicting in advance all ramifications of a retrospective process change. PMID:16114659

  16. The Need for Ocean Literacy in the Classroom: Part II

    ERIC Educational Resources Information Center

    Schoedinger, Sarah; Cava, Francesca; Jewell, Beth

    2006-01-01

    As mentioned in Part I, certain classroom activities can help students learn about the ocean and empower them to make informed decisions about their impacts on the environment. One such activity focuses on harmful algal blooms (HABs). In this article, the authors include background information on HABs and then present two activities. Activity 1 is…

  17. Recent advances in small bowel diseases: Part II

    PubMed Central

    Thomson, Alan BR; Chopra, Angeli; Clandinin, Michael Tom; Freeman, Hugh

    2012-01-01

    As is the case in all areas of gastroenterology and hepatology, in 2009 and 2010 there were many advances in our knowledge and understanding of small intestinal diseases. Over 1000 publications were reviewed, and the important advances in basic science as well as clinical applications were considered. In Part II we review six topics: absorption, short bowel syndrome, smooth muscle function and intestinal motility, tumors, diagnostic imaging, and cystic fibrosis. PMID:22807605

  18. CATALYST ACTIVITY MAINTENANCE FOR THE LIQUID PHASE SYNTHESIS GAS-TO-DIMETHYL ETHER PROCESS PART II: DEVELOPMENT OF ALUMINUM PHOSPHATE AS THE DEHYDRATION CATALYST FOR THE SINGLE-STEP LIQUID PHASE SYNGAS-TO-DME PROCESS

    SciTech Connect

    Xiang-Dong Peng

    2002-05-01

    At the heart of the single-step liquid phase syngas-to-DME process (LPDME{trademark}) is a catalyst system that can be active as well as stable. In the Alternative Fuels I program, a dual-catalyst system containing a Cu-based commercial methanol synthesis catalyst (BASF S3-86) and a commercial dehydration material ({gamma}-alumina) was demonstrated. It provided the productivity and selectivity expected from the LPDME process. However, the catalyst system deactivated too rapidly to warrant a viable commercial process [1]. The mechanistic investigation in the early part of the DOE's Alternative Fuels II program revealed that the accelerated catalyst deactivation under LPDME conditions is due to detrimental interaction between the methanol synthesis catalyst and methanol dehydration catalyst [2,3]. The interaction was attributed to migration of Cu- and/or Zn-containing species from the synthesis catalyst to the dehydration catalyst. Identification of a dehydration catalyst that did not lead to this detrimental interaction while retaining adequate dehydration activity was elusive. Twenty-nine different dehydration materials were tested, but none showed the desired performance [2]. The search came to a turning point when aluminum phosphate was tested. This amorphous material is prepared by precipitating a solution containing Al(NO{sub 3}){sub 3} and H{sub 3}PO{sub 4} with NH{sub 4}OH, followed by washing, drying and calcination. The aluminum phosphate catalyst has adequate dehydration activity and good stability. It can co-exist with the Cu-based methanol synthesis catalyst without negatively affecting the latter catalyst's stability. This report documents the details of the development of this catalyst. These include initial leads, efforts in improving activity and stability, investigation and development of the best preparation parameters and procedures, mechanistic understanding and resulting preparation guidelines, and the accomplishments of this work.

  19. Probabilistic finite-state machines--part II.

    PubMed

    Vidal, Enrique; Thollard, Frank; de la Higuera, Colin; Casacuberta, Francisco; Carrasco, Rafael C

    2005-07-01

    Probabilistic finite-state machines are used today in a variety of areas in pattern recognition or in fields to which pattern recognition is linked. In Part I of this paper, we surveyed these objects and studied their properties. In this Part II, we study the relations between probabilistic finite-state automata and other well-known devices that generate strings like hidden Markov models and n-grams and provide theorems, algorithms, and properties that represent a current state of the art of these objects. PMID:16013751

  20. The Value of Imaging Part II: Value beyond Image Interpretation.

    PubMed

    Duong, Phuong-Anh T; Pastel, David A; Sadigh, Gelareh; Ballard, David; Sullivan, Joseph C; Bresnahan, Brian; Buch, Karen; Duszak, Richard

    2016-01-01

    Although image interpretation is an essential part of radiologists' value, there are other ways in which we contribute to patient care. Part II of the value of imaging series reviews current initiatives that demonstrate value beyond the image interpretation. Standardizing processes, reducing the radiation dose of our examinations, clarifying written reports, improving communications with patients and providers, and promoting appropriate imaging through decision support are all ways we can provide safer, more consistent, and higher quality care. As payers and policy makers push to drive value, research that demonstrates the value of these endeavors, or lack thereof, will become increasingly sought after and supported. PMID:26683509

  1. IPCC Working Group II: Impacts and Adaptation Part I

    NASA Astrophysics Data System (ADS)

    Pulwarty, R. S.

    2007-12-01

    The IPCC (as opposed to the UN Framework Convention) defines climate change as" any change in climate over time, whether due to natural variability or as a result of human activity". The IPCC Working Group II (Impacts, Adaptation, Vulnerability) was charged with assessing the scientific, technical, environmental, economic, and social aspects of vulnerability to climate change, and, the negative and positive consequences for ecological systems, socio-economic sectors, and human health. The Working Group II report focused on the following issues for different sectors and regions (e.g. water, agriculture, biodiversity) and communities (coastal, island, etc.): · The role of adaptation in reducing vulnerability and impacts, · Assessment of adaptation capacity, options and constraints, and · Enhancing adaptation practice and operations. This presentation will address the following questions in the context of the results of the IPCC Fourth Assessment Report WG II: · What are the barriers, knowledge gaps, and opportunities for impacts assessments? · How are decisions about adaptation being made, and what types of adaptation strategies are being undertaken? · What are good adaptation practices and how are they learned over time? Examples will be drawn from the freshwater resources, small islands and adaptation chapters to which the presenter contributed. Many lessons have been identified but few have been implemented or evaluated over time. Adaptation occurs in the context of multiple stresses. Adaptation will be important in coping with early impacts in the near-term and continue to be important as our climate changes, regardless of how that change is derived. It is important to note that unmitigated climate change could, in the long term, exceed the capacity of different natural, managed and human systems to adapt. The assessment leads to the following conclusions: · Adaptation to climate change is already taking place, but on a limited basis · Adaptation measures

  2. Research Papers Sponsored by the Commission on Private Philanthropy and Public Needs. Volume II: Philanthropic Fields of Interest, Part II-Additional Perspectives.

    ERIC Educational Resources Information Center

    Department of the Treasury, Washington, DC.

    Twelve papers discuss future changes and trends in philanthropic giving and activities. The report is Volume II, Part II of a five volume series examining the relationship between nonprofit institutions and their donors. The opening paper reviews the needs for better definition of the government's role in contracting and grant making, and for…

  3. Care of the patient with chronic pain: part II.

    PubMed

    Wells-Federman, C L

    2000-01-01

    Chronic nonmalignant pain frequently results in significant physical, behavioral, psychological, social, and spiritual issues for patients and their families. It is often misunderstood and unsuccessfully managed. Advanced practice nurses who are knowledgeable about chronic pain and the complex biopsychosocial-spiritual needs of this patient population serve an important role in recognizing these patients and intervening appropriately in their care. The purpose of this two-part article is to provide that information. Part I [Clinical Excellence for Nurse Practitioners, 3 (4), 192-204] outlined the pathophysiology, assessment, biopsychosocial-spiritual aspects, and pharmacologic treatment of chronic pain. In Part II, a variety of nonpharmacologic and self-management interventions one can use in the primary care setting to treat these difficult health problems are introduced. PMID:11858295

  4. Health Activities Project (HAP), Trial Edition II.

    ERIC Educational Resources Information Center

    Buller, Dave; And Others

    Contained within this Health Activities Project (HAP) trial edition (set II) are a teacher information folio and numerous student activity folios which center around the idea that students in grades 5-8 can control their own health and safety. Each student folio is organized into a Synopsis, Health Background, Materials, Setting Up, and Activities…

  5. Polycystic ovary syndrome: a review for dermatologists: Part II. Treatment.

    PubMed

    Buzney, Elizabeth; Sheu, Johanna; Buzney, Catherine; Reynolds, Rachel V

    2014-11-01

    Dermatologists are in a key position to treat the manifestations of polycystic ovary syndrome (PCOS). The management of PCOS should be tailored to each woman's specific goals, reproductive interests, and particular constellation of symptoms. Therefore, a multidisciplinary approach is recommended. In part II of this continuing medical education article, we present the available safety and efficacy data regarding treatments for women with acne, hirsutism, and androgenetic alopecia. Therapies discussed include lifestyle modification, topical therapies, combined oral contraceptives, antiandrogen agents, and insulin-sensitizing drugs. Treatment recommendations are made based on the current available evidence. PMID:25437978

  6. Structure Learning and Statistical Estimation in Distribution Networks - Part II

    SciTech Connect

    Deka, Deepjyoti; Backhaus, Scott N.; Chertkov, Michael

    2015-02-13

    Limited placement of real-time monitoring devices in the distribution grid, recent trends notwithstanding, has prevented the easy implementation of demand-response and other smart grid applications. Part I of this paper discusses the problem of learning the operational structure of the grid from nodal voltage measurements. In this work (Part II), the learning of the operational radial structure is coupled with the problem of estimating nodal consumption statistics and inferring the line parameters in the grid. Based on a Linear-Coupled(LC) approximation of AC power flows equations, polynomial time algorithms are designed to identify the structure and estimate nodal load characteristics and/or line parameters in the grid using the available nodal voltage measurements. Then the structure learning algorithm is extended to cases with missing data, where available observations are limited to a fraction of the grid nodes. The efficacy of the presented algorithms are demonstrated through simulations on several distribution test cases.

  7. The "Pseudocommando" mass murderer: part II, the language of revenge.

    PubMed

    Knoll, James L

    2010-01-01

    In Part I of this article, research on pseudocommandos was reviewed, and the important role that revenge fantasies play in motivating such persons to commit mass murder-suicide was discussed. Before carrying out their mass shootings, pseudocommandos may communicate some final message to the public or news media. These communications are rich sources of data about their motives and psychopathology. In Part II of this article, forensic psycholinguistic analysis is applied to clarify the primary motivations, detect the presence of mental illness, and discern important individual differences in the final communications of two recent pseudocommandos: Seung-Hui Cho (Virginia Tech) and Jiverly Wong (Binghamton, NY). Although both men committed offenses that qualify them as pseudocommandos, their final communications reveal striking differences in their psychopathology. PMID:20542949

  8. Arm-free paraplegic standing--Part II: Experimental results.

    PubMed

    Matjacić, Z; Bajd, T

    1998-06-01

    In Part I, we proposed an approach for restoring unsupported standing to thoracic-level paraplegics. The theoretical analysis and simulation of an underactuated double inverted pendulum, representing the standing subject, showed that arm-free standing might be achieved. Here in Part II, we present the mechanical apparatus which we used in our experiments and experimental results from tests of the balance-control strategy. We demonstrate that an intact and a paraplegic subject could perform quiet standing with the ankle stiffness set to 8 Nm/degree or even less (the intact subject). Both were also able to recover from disturbances, imposed by the artificial ankle joint of the apparatus. Introducing cognitive auditory feedback greatly improved the standing abilities of both subjects. PMID:9631321

  9. PREREM: an interactive data preprocessing code for INREM II. Part I: user's manual. Part II: code structure

    SciTech Connect

    Ryan, M.T.; Fields, D.E.

    1981-05-01

    PREREM is an interactive computer code developed as a data preprocessor for the INREM-II (Killough, Dunning, and Pleasant, 1978a) internal dose program. PREREM is intended to provide easy access to current and self-consistent nuclear decay and radionuclide-specific metabolic data sets. Provision is made for revision of metabolic data, and the code is intended for both production and research applications. Documentation for the code is in two parts. Part I is a user's manual which emphasizes interpretation of program prompts and choice of user input. Part II stresses internal structure and flow of program control and is intended to assist the researcher who wishes to revise or modify the code or add to its capabilities. PREREM is written for execution on a Digital Equipment Corporation PDP-10 System and much of the code will require revision before it can be run on other machines. The source program length is 950 lines (116 blocks) and computer core required for execution is 212 K bytes. The user must also have sufficient file space for metabolic and S-factor data sets. Further, 64 100 K byte blocks of computer storage space are required for the nuclear decay data file. Computer storage space must also be available for any output files produced during the PREREM execution. 9 refs., 8 tabs.

  10. Blade System Design Study. Part II, final project report (GEC).

    SciTech Connect

    Griffin, Dayton A.

    2009-05-01

    As part of the U.S. Department of Energy's Low Wind Speed Turbine program, Global Energy Concepts LLC (GEC)1 has studied alternative composite materials for wind turbine blades in the multi-megawatt size range. This work in one of the Blade System Design Studies (BSDS) funded through Sandia National Laboratories. The BSDS program was conducted in two phases. In the Part I BSDS, GEC assessed candidate innovations in composite materials, manufacturing processes, and structural configurations. GEC also made recommendations for testing composite coupons, details, assemblies, and blade substructures to be carried out in the Part II study (BSDS-II). The BSDS-II contract period began in May 2003, and testing was initiated in June 2004. The current report summarizes the results from the BSDS-II test program. Composite materials evaluated include carbon fiber in both pre-impregnated and vacuum-assisted resin transfer molding (VARTM) forms. Initial thin-coupon static testing included a wide range of parameters, including variation in manufacturer, fiber tow size, fabric architecture, and resin type. A smaller set of these materials and process types was also evaluated in thin-coupon fatigue testing, and in ply-drop and ply-transition panels. The majority of materials used epoxy resin, with vinyl ester (VE) resin also used for selected cases. Late in the project, testing of unidirectional fiberglass was added to provide an updated baseline against which to evaluate the carbon material performance. Numerous unidirectional carbon fabrics were considered for evaluation with VARTM infusion. All but one fabric style considered suffered either from poor infusibility or waviness of fibers combined with poor compaction. The exception was a triaxial carbon-fiberglass fabric produced by SAERTEX. This fabric became the primary choice for infused articles throughout the test program. The generally positive results obtained in this program for the SAERTEX material have led to its being

  11. 31 CFR Appendix II(f) to Part 13 - Overhead and Administrative Costs

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Overhead and Administrative Costs II(F) Appendix II(F) to Part 13 Money and Finance: Treasury Office of the Secretary of the Treasury... Pt. 13, App. II(F) Appendix II(F) to Part 13—Overhead and Administrative Costs Date: Select Only...

  12. 29 CFR Appendix II to Part 1918 - Tables for Selected Miscellaneous Auxiliary Gear (Mandatory)

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Tables for Selected Miscellaneous Auxiliary Gear (Mandatory) II Appendix II to Part 1918 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Pt. 1918, App. II Appendix II to Part...

  13. 19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for...

  14. 19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for...

  15. 5 CFR Appendix II to Part 1201 - Appropriate Regional or Field Office for Filing Appeals

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Appropriate Regional or Field Office for Filing Appeals II Appendix II to Part 1201 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES AND PROCEDURES Pt. 1201, App. II Appendix II to Part 1201—Appropriate Regional or Field Office for Filing...

  16. 29 CFR Appendix II to Part 1918 - Tables for Selected Miscellaneous Auxiliary Gear (Mandatory)

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Tables for Selected Miscellaneous Auxiliary Gear (Mandatory) II Appendix II to Part 1918 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Pt. 1918, App. II Appendix II to Part...

  17. 31 CFR Appendix II(f) to Part 13 - Overhead and Administrative Costs

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Overhead and Administrative Costs II(F) Appendix II(F) to Part 13 Money and Finance: Treasury Office of the Secretary of the Treasury... Pt. 13, App. II(F) Appendix II(F) to Part 13—Overhead and Administrative Costs Date: Select Only...

  18. A Survey of Optometry Graduates to Determine Practice Patterns: Part II: Licensure and Practice Establishment Experiences.

    ERIC Educational Resources Information Center

    Bleimann, Robert L.; Smith, Lee W.

    1985-01-01

    A summary of Part II of a two-volume study of optometry graduates conducted by the Association of Schools and Colleges of Optometry is presented. Part II includes the analysis of the graduates' licensure and practice establishment experiences. (MLW)

  19. 77 FR 60743 - Proposed Collection; Comment Request for Schedule F, Part II and III (Form 1040)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... Internal Revenue Service Proposed Collection; Comment Request for Schedule F, Part II and III (Form 1040... Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Schedule F... Number: Schedule F, Part II and III (Form 1040). Abstract: Schedule F, Part II and III (Form 1040)...

  20. Generalized Interference Alignment—Part II: Application to Wireless Secrecy

    NASA Astrophysics Data System (ADS)

    Ruan, Liangzhong; Lau, Vincent K. N.; Win, Moe Z.

    2016-05-01

    In contrast to its wired counterpart, wireless communication is highly susceptible to eavesdropping due to the broadcast nature of the wireless propagation medium. Recent works have proposed the use of interference to reduce eavesdropping capabilities in wireless wiretap networks. However, the concurrent effect of interference on both eavesdropping receivers (ERs) and legitimate receivers (LRs) has not been thoroughly investigated, and carefully engineering the network interference is required to harness the full potential of interference for wireless secrecy. This two part paper addresses this issue by proposing a generalized interference alignment (GIA) technique, which jointly designs the transceivers at the legitimate partners to impede the ERs without interfering with LRs. In Part I, we have established a theoretical framework for the GIA technique. In Part II, we will first propose an efficient GIA algorithm that is applicable to large-scale networks and then evaluate the performance of this algorithm in stochastic wireless wiretap network via both analysis and simulation. These results reveal insights into when and how GIA contributes to wireless secrecy.

  1. Spontaneous "cures": Norman Reider's forgotten paper, part II.

    PubMed

    Boesky, Dale

    2014-04-01

    Part I of this paper combined an introduction to Norman Reider's original 1955 paper with a republication of the paper itself. Part II is a discussion of the complexities of a comparison of past and present psychoanalytic literature. The concept of enactment is proposed as one of many possible alternative views in considering Reider's notion of spontaneous "cures." A careful consideration of these spontaneous cures within the ordinary ups and downs of any psychoanalytic treatment sheds important light on our continuing confusion about how we define the term cure, and therefore about the nature of change during psychoanalytic treatment. This alternative perspective is only one of many plausible ones for present-day readers. The purpose of this republication is not to propose an explanation for "what really happened" with Reider and his patients; rather, it is to reconsider the fallacy of evaluating his paper outside its historical context and thereby failing to appreciate his courage in presenting what at the time were radical views. Questions about the complexity and confusion regarding cure and change require reexamination of the neglect of epistemology on the part of psychoanalysis in prolonging the confusion about distinguishing psychotherapy and psychoanalysis. PMID:24777370

  2. 49 CFR Appendix A-Ii to Part 541 - Lines With Antitheft Devices Which Are Exempted in-Part From the Parts-Marking Requirements of...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 A Appendix A-II...-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 Manufacturers... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE THEFT...

  3. 49 CFR Appendix A-Ii to Part 541 - Lines With Antitheft Devices Which Are Exempted In-Part From the Parts-Marking Requirements of...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 A Appendix A-II...-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 Manufacturers... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE THEFT...

  4. 49 CFR Appendix A-Ii to Part 541 - Lines With Antitheft Devices Which Are Exempted In-Part From the Parts-Marking Requirements of...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 A Appendix A-II...-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 Manufacturers... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE THEFT...

  5. Revision of the Genus Paratylenchus Micoletzky, 1922 and Descriptions of New Species. Part II of Three Parts

    PubMed Central

    Raski, D. J.

    1975-01-01

    Part II covers species with average female stylet length of 22-38 μm. Seven new species are described and further observations are given on 12 other species. A key to the species covered in Parts I and II is included. Paratylenchus curvitatus van der Linde, 1938, is transferred to species inquirendae. PMID:19308171

  6. II: Through the Western Part of the City: Charlottenburg

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    Until 1920 the city we now call Berlin was a collection of independent towns and villages — among them Charlottenburg, which was one of the most important and was the proud sister of Berlin, Prussia’s and Germany’s capital, where the wealthy and innovative bourgeoisie lived. Werner von Siemens, Germany’s pioneer in the modern electrical industry, was a prime example of that elite. His castle-like villa was located not far from today’s Ernst-Reuter-Platz at Otto-Suhr-Allee 10-16, and important parts of his enterprise expanded into the “meadows outside of Charlottenburg” during the second half of the 19th century. It was no accident that the efforts to unite Berlin’s two colleges for trade and construction (both founded around 1800) led to the foundation of a modern Technical College in Charlottenburg in 1879, today’s Technical University of Berlin. Its magnificent main building (figure 1), which was opened in 1882 by the German Emperor, was an expression of the great self-confidence of this new institution of higher learning and of Charlottenburg’s bourgeoisie. Although large parts of the building were destroyed by bombs during World War II, you can still get an impression of its monumentality from what survived at number 135 Strasse des 17. Juni.

  7. A Probabilistic Foundation of Elementary Particle Statistics. Part II.

    NASA Astrophysics Data System (ADS)

    Costantini, Domenico; Garibaldi, Ubaldo

    The long history of ergodic and quasi-ergodic hypotheses provides the best example of the attempt to supply non-probabilistic justifications for the use of statistical mechanics in describing mechanical systems. In this paper we reverse the terms of the problem. We aim to show that accepting a probabilistic foundation of elementary particle statistics dispenses with the need to resort to ambiguous non-probabilistic notions like that of (in)distinguishability. In the quantum case, starting from suitable probability conditions, it is possible to deduce elementary particle statistics in a unified way. Following our approach Maxwell-Boltzmann statistics can also be deduced, and this deduction clarifies its status. Thus our primary aim in this paper is to give a mathematically rigorous deduction of the probability of a state with given energy for a perfect gas in statistical equilibrium; that is, a deduction of the equilibrium distributions for a perfect gas. A crucial step in this deduction is the statement of a unified statistical theory based on clearly formulated probability conditions from which the particle statistics follows. We believe that such a deduction represents an important improvement in elementary particle statistics, and a step towards a probabilistic foundation of statistical mechanics. The present Part II is devoted to this deduction. Part I presented the necessary tools. After the deduction of the probability of a state with given energy for a system in statistical equilibrium, we will propose in the last section a simple model giving an ergodic interpretation of the equilibrium distributions.

  8. Hypoelastic Soft Tissues: Part II: In-Plane Biaxial Experiments.

    PubMed

    Freed, Alan D; Einstein, Daniel R; Sacks, Michael S

    2010-08-01

    In Part I, a novel hypoelastic framework for soft-tissues was presented. One of the hallmarks of this new theory is that the well-known exponential behavior of soft-tissues arises consistently and spontaneously from the integration of a rate based formulation. In Part II, we examine the application of this framework to the problem of biaxial kinematics, which are common in experimental soft-tissue characterization. We confine our attention to an isotropic formulation in order to highlight the distinction between non-linearity and anisotropy. In order to provide a sound foundation for the membrane extension of our earlier hypoelastic framework, the kinematics and kinetics of in-plane biaxial extension are revisited, and some enhancements are provided. Specifically, the conventional stress-to-traction mapping for this boundary value problem is shown to violate the conservation of angular momentum. In response, we provide a corrected mapping. In addition, a novel means for applying loads to in-plane biaxial experiments is proposed. An isotropic, isochoric, hypoelastic, constitutive model is applied to an in-plane biaxial experiment done on glutaraldehyde treated bovine pericardium. The experiment is comprised of eight protocols that radially probe the biaxial plane. Considering its simplicity (two adjustable parameters) the model does a reasonably good job of describing the non-linear normal responses observed in these experimental data, which are more prevalent than are the anisotropic responses exhibited by this tissue. PMID:21394222

  9. Branch Flow Model: Relaxations and Convexification-Part II

    SciTech Connect

    Farivar, M; Low, SH

    2013-08-01

    We propose a branch flow model for the analysis and optimization of mesh as well as radial networks. The model leads to a new approach to solving optimal power flow (OPF) that consists of two relaxation steps. The first step eliminates the voltage and current angles and the second step approximates the resulting problem by a conic program that can be solved efficiently. For radial networks, we prove that both relaxation steps are always exact, provided there are no upper bounds on loads. For mesh networks, the conic relaxation is always exact but the angle relaxation may not be exact, and we provide a simple way to determine if a relaxed solution is globally optimal. We propose convexification of mesh networks using phase shifters so that OPF for the convexified network can always be solved efficiently for an optimal solution. We prove that convexification requires phase shifters only outside a spanning tree of the network and their placement depends only on network topology, not on power flows, generation, loads, or operating constraints. Part I introduces our branch flow model, explains the two relaxation steps, and proves the conditions for exact relaxation. Part II describes convexification of mesh networks, and presents simulation results.

  10. Basic Services for Children: A Continuing Search for Learning Priorities. A Dossier for Initiating a Dialogue--Part II, 1978. Experiments and Innovations in Education No. 37.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    Both parts I and II of the dossier are collections of selected activities directed toward the deprived young in a developing world. This book, part II, departs from its predecessor in that it takes a more global view of education services to both children and adults in developing countries. Part A discusses the philosophy and scope of the dossier.…

  11. Reforming Science Education: Part II. Utilizing Kieran Egan's Educational Metatheory

    NASA Astrophysics Data System (ADS)

    Schulz, Roland M.

    2009-04-01

    This paper is the second of two parts and continues the conversation which had called for a shift in the conceptual focus of science education towards philosophy of education, with the requirement to develop a discipline-specific “philosophy” of science education. In Part I, conflicting conceptions of science literacy were identified with disparate “visions” tied to competing research programs as well as school-based curricular paradigms. The impasse in the goals of science education and thereto, the contending views of science literacy, were themselves associated with three underlying fundamental aims of education (knowledge-itself; personal development; socialization) which, it was argued, usually undercut the potential of each other. During periods of “crisis-talk” and throughout science educational history these three aims have repeatedly attempted to assert themselves. The inability of science education research to affect long-term change in classrooms was correlated not only to the failure to reach a consensus on the aims (due to competing programs and to the educational ideologies of their social groups), but especially to the failure of developing true educational theories (largely neglected since Hirst). Such theories, especially metatheories, could serve to reinforce science education’s growing sense of academic autonomy and independence from socio-economic demands. In Part II, I offer as a suggestion Egan’s cultural-linguistic theory as a metatheory to help resolve the impasse. I hope to make reformers familiar with his important ideas in general, and more specifically, to show how they can complement HPS rationales and reinforce the work of those researchers who have emphasized the value of narrative in learning science.

  12. Pharmacokinetics and interactions of headache medications, part II: prophylactic treatments.

    PubMed

    Sternieri, Emilio; Coccia, Ciro Pio Rosario; Pinetti, Diego; Guerzoni, Simona; Ferrari, Anna

    2006-12-01

    The present part II review highlights pharmacokinetic drug-drug interactions (excluding those of minor severity) of medications used in prophylactic treatment of the main primary headaches (migraine, tension-type and cluster headache). The principles of pharmacokinetics and metabolism, and the interactions of medications for acute treatment are examined in part I. The overall goal of this series of two reviews is to increase the awareness of physicians, primary care providers and specialists regarding pharmacokinetic drug-drug interactions (DDIs) of headache medications. The aim of prophylactic treatment is to reduce the frequency of headache attacks using beta-blockers, calcium-channel blockers, antidepressants, antiepileptics, lithium, serotonin antagonists, corticosteroids and muscle relaxants, which must be taken daily for long periods. During treatment the patient often continues to take symptomatic drugs for the attack, and may need other medications for associated or new-onset illnesses. DDIs can, therefore, occur. As a whole, DDIs of clinical relevance concerning prophylactic drugs are a limited number. Their effects can be prevented by starting the treatment with low dosages, which should be gradually increased depending on response and side effects, while frequently monitoring the patient and plasma levels of other possible coadministered drugs with a narrow therapeutic range. Most headache medications are substrates of CYP2D6 (e.g., beta-blockers, antidepressants) or CYP3A4 (e.g., calcium-channel blockers, selective serotonin re-uptake inhibitors, corticosteroids). The inducers and, especially, the inhibitors of these isoenzymes should be carefully coadministered. PMID:17125412

  13. 46 CFR Appendix II to Part 390 - Sample Capital Construction Fund Agreement

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PUBLIC LAW 91-469 CAPITAL CONSTRUCTION FUND Pt. 390, App. II Appendix II to Part 390—Sample Capital... Francisco, Calif. SS Brown, official No. 325111 ......do 265,000 dwt Owned 1974, Southern Shipyards,...

  14. 46 CFR Appendix II to Part 390 - Sample Capital Construction Fund Agreement

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PUBLIC LAW 91-469 CAPITAL CONSTRUCTION FUND Pt. 390, App. II Appendix II to Part 390—Sample Capital... Francisco, Calif. SS Brown, official No. 325111 ......do 265,000 dwt Owned 1974, Southern Shipyards,...

  15. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Notifications II Appendix II to Part 280 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Connecticut (State Form), Hazardous Materials Management Unit, Department of Environmental Protection, State..., Environmental Protection Division, Underground Storage Tank Program, 3420 Norman Berry Drive, 7th...

  16. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Notifications II Appendix II to Part 280 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Connecticut (State Form), Hazardous Materials Management Unit, Department of Environmental Protection, State..., Environmental Protection Division, Underground Storage Tank Program, 3420 Norman Berry Drive, 7th...

  17. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Notifications II Appendix II to Part 280 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Connecticut (State Form), Hazardous Materials Management Unit, Department of Environmental Protection, State..., Environmental Protection Division, Underground Storage Tank Program, 3420 Norman Berry Drive, 7th...

  18. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Notifications II Appendix II to Part 280 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Connecticut (State Form), Hazardous Materials Management Unit, Department of Environmental Protection, State..., Environmental Protection Division, Underground Storage Tank Program, 3420 Norman Berry Drive, 7th...

  19. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Notifications II Appendix II to Part 280 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Connecticut (State Form), Hazardous Materials Management Unit, Department of Environmental Protection, State..., Environmental Protection Division, Underground Storage Tank Program, 3420 Norman Berry Drive, 7th...

  20. Myosin II Activity Softens Cells in Suspension

    PubMed Central

    Chan, Chii J.; Ekpenyong, Andrew E.; Golfier, Stefan; Li, Wenhong; Chalut, Kevin J.; Otto, Oliver; Elgeti, Jens; Guck, Jochen; Lautenschläger, Franziska

    2015-01-01

    The cellular cytoskeleton is crucial for many cellular functions such as cell motility and wound healing, as well as other processes that require shape change or force generation. Actin is one cytoskeleton component that regulates cell mechanics. Important properties driving this regulation include the amount of actin, its level of cross-linking, and its coordination with the activity of specific molecular motors like myosin. While studies investigating the contribution of myosin activity to cell mechanics have been performed on cells attached to a substrate, we investigated mechanical properties of cells in suspension. To do this, we used multiple probes for cell mechanics including a microfluidic optical stretcher, a microfluidic microcirculation mimetic, and real-time deformability cytometry. We found that nonadherent blood cells, cells arrested in mitosis, and naturally adherent cells brought into suspension, stiffen and become more solidlike upon myosin inhibition across multiple timescales (milliseconds to minutes). Our results hold across several pharmacological and genetic perturbations targeting myosin. Our findings suggest that myosin II activity contributes to increased whole-cell compliance and fluidity. This finding is contrary to what has been reported for cells attached to a substrate, which stiffen via active myosin driven prestress. Our results establish the importance of myosin II as an active component in modulating suspended cell mechanics, with a functional role distinctly different from that for substrate-adhered cells. PMID:25902426

  1. Myosin II Activity Softens Cells in Suspension.

    PubMed

    Chan, Chii J; Ekpenyong, Andrew E; Golfier, Stefan; Li, Wenhong; Chalut, Kevin J; Otto, Oliver; Elgeti, Jens; Guck, Jochen; Lautenschläger, Franziska

    2015-04-21

    The cellular cytoskeleton is crucial for many cellular functions such as cell motility and wound healing, as well as other processes that require shape change or force generation. Actin is one cytoskeleton component that regulates cell mechanics. Important properties driving this regulation include the amount of actin, its level of cross-linking, and its coordination with the activity of specific molecular motors like myosin. While studies investigating the contribution of myosin activity to cell mechanics have been performed on cells attached to a substrate, we investigated mechanical properties of cells in suspension. To do this, we used multiple probes for cell mechanics including a microfluidic optical stretcher, a microfluidic microcirculation mimetic, and real-time deformability cytometry. We found that nonadherent blood cells, cells arrested in mitosis, and naturally adherent cells brought into suspension, stiffen and become more solidlike upon myosin inhibition across multiple timescales (milliseconds to minutes). Our results hold across several pharmacological and genetic perturbations targeting myosin. Our findings suggest that myosin II activity contributes to increased whole-cell compliance and fluidity. This finding is contrary to what has been reported for cells attached to a substrate, which stiffen via active myosin driven prestress. Our results establish the importance of myosin II as an active component in modulating suspended cell mechanics, with a functional role distinctly different from that for substrate-adhered cells. PMID:25902426

  2. Catalytically active lead(ii)-imidazolium coordination assemblies with diversified lead(ii) coordination geometries.

    PubMed

    Naga Babu, Chatla; Suresh, Paladugu; Srinivas, Katam; Sathyanarayana, Arruri; Sampath, Natarajan; Prabusankar, Ganesan

    2016-05-10

    Five Pb(ii)-imidazolium carboxylate coordination assemblies with novel structural motifs were derived from the reaction between the corresponding flexible, semi flexible or rigid imidazolium carboxylic acid ligands and lead nitrate. The imidazolium linker present in these molecules likely plays a triple role such as the counter ion to balance the metal charge, the ligand being an integral part of the final product and the catalyst facilitating carbon-carbon bond formation reaction. These lead-imidazolium coordination assemblies exhibit, variable chemical and thermal stabilities, as well as catalytic activity. These newly prepared catalysts are highly active towards benzoin condensation reactions with good functional group tolerance. PMID:27093629

  3. 10 CFR Appendix II to Part 1050 - DOE Form 3735.3-Foreign Travel Statement

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Pub. L. 95-105, August 17, 1977) and DOE implementing regulations at 10 CFR part 1050. These... 10 Energy 4 2010-01-01 2010-01-01 false DOE Form 3735.3-Foreign Travel Statement II Appendix II to.... II Appendix II to Part 1050—DOE Form 3735.3—Foreign Travel Statement EC01OC91.041...

  4. Phosphorylation-independent stimulation of DNA topoisomerase II alpha activity.

    PubMed

    Kimura, K; Saijo, M; Tanaka, M; Enomoto, T

    1996-05-01

    It has been suggested that casein kinase II phosphorylates DNA topoisomerase II alpha (topo II alpha) in mouse FM3A cells, by comparison of phosphopeptide maps of topo II alpha labeled in intact cells and of topo II alpha phosphorylated by various kinases in vitro. The phosphorylation of purified topo II alpha by casein kinase II, which attached a maximum of two phosphate groups per topo II alpha molecule, had no effect on the activity of topo II alpha. Dephosphorylation of purified topo II alpha by potato acid phosphatase, which almost completely dephosphorylated the topo II alpha, did not reduce the activity of topo II alpha. The incubation itself, regardless of phosphorylation or dephosphorylation status, stimulated the enzyme activity in both reactions. Topo II alpha activity was stimulated by incubation in a medium containing low concentrations of glycerol but not in that containing high concentrations of glycerol, such as the 50% in which purified topo II alpha is stored. The stimulation of topo II alpha activity by incubation was dependent on the concentration of topo II alpha, requiring a relatively high concentration of topo II alpha. PMID:8631919

  5. Complexes With Biologically Active Ligands. Part 101 Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b ]-1,3,4-Thiadiazole-2-Sulfonamide

    PubMed Central

    Scozzafava, Andrea

    1997-01-01

    The title compound was prepared by an improved variant of the literature procedure, and metal complexes containing its anion and the following metal ions: Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Cu(II), V(IV), Fe(III) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, NMR and EPR spectroscopy; TG, magnetic and conductimetric measurements). The parent sulfonamide and its metal complexes are potent inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II, and they might possess applications as selective cerebrovasodilating agents. PMID:18475761

  6. Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part II: Alkaloids, Terpenoids and Flavonoids.

    PubMed

    Nwodo, Justina N; Ibezim, Akachukwu; Simoben, Conrad V; Ntie-Kang, Fidele

    2016-01-01

    Cancer stands as second most common cause of disease-related deaths in humans. Resistance of cancer to chemotherapy remains challenging to both scientists and physicians. Medicinal plants are known to contribute significantly to a large population of Africa, which is to a very large extent linked to folkloric claims which is part of their livelihood. In this review paper, the potential of naturally occurring anti-cancer agents from African flora has been explored, with suggested modes of action, where such data is available. Literature search revealed plant-derived compounds from African flora showing anti-cancer and/or cytotoxic activities, which have been tested in vitro and in vivo. This corresponds to 400 compounds (from mildly active to very active) covering various compound classes. However, in this part II, we only discussed the three major compound classes which are: flavonoids, alkaloids and terpenoids. PMID:25991425

  7. Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms.

    PubMed Central

    Biersack, H; Jensen, S; Gromova, I; Nielsen, I S; Westergaard, O; Andersen, A H

    1996-01-01

    DNA topoisomerase II is a nuclear enzyme essential for chromosome dynamics and DNA metabolism. In mammalian cells, two genetically and biochemically distinct topoisomerase II forms exist, which are designated topoisomerase II alpha and topoisomerase II beta. In our studies of human topoisomerase II, we have found that a substantial fraction of the enzyme exists as alpha/beta heterodimers in HeLa cells. The ability to form heterodimers was verified when human topoisomerases II alpha and II beta were coexpressed in yeast and investigated in a dimerization assay. Analysis of purified heterodimers shows that these enzymes maintain topoisomerase II specific catalytic activities. The natural existence of an active heterodimeric subclass of topoisomerase II merits attention whenever topoisomerases II alpha and II beta function, localization, and cell cycle regulation are investigated. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:8710863

  8. Autism and EMF? Plausibility of a pathophysiological link part II.

    PubMed

    Herbert, Martha R; Sage, Cindy

    2013-06-01

    Autism spectrum conditions (ASCs) are defined behaviorally, but they also involve multileveled disturbances of underlying biology that find striking parallels in the physiological impacts of electromagnetic frequency and radiofrequency radiation exposures (EMF/RFR). Part I (Vol 776) of this paper reviewed the critical contributions pathophysiology may make to the etiology, pathogenesis and ongoing generation of behaviors currently defined as being core features of ASCs. We reviewed pathophysiological damage to core cellular processes that are associated both with ASCs and with biological effects of EMF/RFR exposures that contribute to chronically disrupted homeostasis. Many studies of people with ASCs have identified oxidative stress and evidence of free radical damage, cellular stress proteins, and deficiencies of antioxidants such as glutathione. Elevated intracellular calcium in ASCs may be due to genetics or may be downstream of inflammation or environmental exposures. Cell membrane lipids may be peroxidized, mitochondria may be dysfunctional, and various kinds of immune system disturbances are common. Brain oxidative stress and inflammation as well as measures consistent with blood-brain barrier and brain perfusion compromise have been documented. Part II of this paper documents how behaviors in ASCs may emerge from alterations of electrophysiological oscillatory synchronization, how EMF/RFR could contribute to these by de-tuning the organism, and policy implications of these vulnerabilities. It details evidence for mitochondrial dysfunction, immune system dysregulation, neuroinflammation and brain blood flow alterations, altered electrophysiology, disruption of electromagnetic signaling, synchrony, and sensory processing, de-tuning of the brain and organism, with autistic behaviors as emergent properties emanating from this pathophysiology. Changes in brain and autonomic nervous system electrophysiological function and sensory processing predominate, seizures

  9. 49 CFR Appendix A-Ii to Part 541 - Lines With Antitheft Devices Which Are Exempted In-Part From the Parts-Marking Requirements of...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Lines With Antitheft Devices Which Are Exempted In-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 A Appendix A-II to Part 541 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT...

  10. Active site specificity of plasmepsin II.

    PubMed Central

    Westling, J.; Cipullo, P.; Hung, S. H.; Saft, H.; Dame, J. B.; Dunn, B. M.

    1999-01-01

    Members of the aspartic proteinase family of enzymes have very similar three-dimensional structures and catalytic mechanisms. Each, however, has unique substrate specificity. These distinctions arise from variations in amino acid residues that line the active site subsites and interact with the side chains of the amino acids of the peptides that bind to the active site. To understand the unique binding preferences of plasmepsin II, an enzyme of the aspartic proteinase class from the malaria parasite, Plasmodium falciparum, chromogenic octapeptides having systematic substitutions at various positions in the sequence were analyzed. This enabled the design of new, improved substrates for this enzyme (Lys-Pro-Ile-Leu-Phe*Nph-Ala/Glu-Leu-Lys, where * indicates the cleavage point). Additionally, the crystal structure of plasmepsin II was analyzed to explain the binding characteristics. Specific amino acids (Met13, Ser77, and Ile287) that were suspected of contributing to active site binding and specificity were chosen for site-directed mutagenesis experiments. The Met13Glu and Ile287Glu single mutants and the Met13Glu/Ile287Glu double mutant gain the ability to cleave substrates containing Lys residues. PMID:10548045

  11. The year's new drugs & biologics 2014 - Part II: trends & challenges.

    PubMed

    Graul, A I; Serebrov, M; Cruces, E; Tracy, M; Dulsat, C

    2015-02-01

    2014 was a year of continued high activity in the pharma and biotech industry, as evidenced in part I of this annual two-part review article published last month in this journal (1). As of December 23, 2014, a total of 55 new chemical and biological entities had reached their first markets worldwide, together with another 29 important new line extensions. Another 19 products were approved for the first time during the year but not yet launched by December 23. Furthermore, during the now-traditional year-end sprint, several regulatory agencies issued last-minute approvals for other compounds that missed the deadline for inclusion in that article, bringing the total of new approvals for the year to a somewhat higher number. In addition to the successful development, registration and launch of new drugs and biologics, there are various other trends and tendencies that serve as indicators of the overall health and status of the industry. These include the pursuit of novel programs designed by regulators to stimulate the development of drugs for diseases that are currently under-treated; the regular and pragmatic culling by companies of their R&D pipelines; and the decision to unify pipelines, portfolios and sales forces through mergers and acquisitions. PMID:25756068

  12. NMG documentation. Part II. Programmer`s guide

    SciTech Connect

    Fritsch, F.N.; Dickinson, R.P. Jr.

    1996-07-01

    This is the 2nd of a 3-part report documenting NMG, the Numerical Mathematics Guide. This part is aimed at the programmer and contains Chapter 2, how it works. (Part I is aimed at the user of the system; Part III is aimed at the maintainer of NMG and will receive only limited distribution.)

  13. A legacy of struggle: the OSHA ergonomics standard and beyond, Part II.

    PubMed

    Delp, Linda; Mojtahedi, Zahra; Sheikh, Hina; Lemus, Jackie

    2014-11-01

    The OSHA ergonomics standard issued in 2000 was repealed within four months through a Congressional resolution that limits future ergonomics rulemaking. This section continues the conversation initiated in Part I, documenting a legacy of struggle for an ergonomics standard through the voices of eight labor, academic, and government key informants. Part I summarized important components of the standard; described the convergence of labor activism, research, and government action that laid the foundation for a standard; and highlighted the debates that characterized the rulemaking process. Part II explores the anti-regulatory political landscape of the 1990s, as well as the key opponents, power dynamics, and legal maneuvers that led to repeal of the standard. This section also describes the impact of the ergonomics struggle beyond the standard itself and ends with a discussion of creative state-level policy initiatives and coalition approaches to prevent work-related musculoskeletal disorders (WMSDs) in today's sociopolitical context. PMID:25261029

  14. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... during idle at its warm idle speed as described in 40 CFR 1065.510. (b) Test nonhandheld engines with one... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Duty Cycles for Laboratory Testing II.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  15. 40 CFR Appendix II to Part 600 - Sample Fuel Economy Calculations

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Sample Fuel Economy Calculations II... FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. II Appendix II to Part 600—Sample Fuel Economy Calculations (a) This sample fuel economy calculation is applicable...

  16. 40 CFR Appendix II to Part 600 - Sample Fuel Economy Calculations

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Sample Fuel Economy Calculations II... FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. II Appendix II to Part 600—Sample Fuel Economy Calculations (a) This sample fuel economy calculation is applicable...

  17. 40 CFR Appendix II to Part 600 - Sample Fuel Economy Calculations

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Sample Fuel Economy Calculations II... FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. II Appendix II to Part 600—Sample Fuel Economy Calculations (a) This sample fuel economy calculation is applicable...

  18. 46 CFR Appendix II to Part 390 - Sample Capital Construction Fund Agreement

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Sample Capital Construction Fund Agreement II Appendix... PUBLIC LAW 91-469 CAPITAL CONSTRUCTION FUND Pt. 390, App. II Appendix II to Part 390—Sample Capital Construction Fund Agreement capital construction fund agreement with This Capital Construction Fund...

  19. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... during idle at its warm idle speed as described in 40 CFR 1065.510. (b) Test nonhandheld engines with one... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Duty Cycles for Laboratory Testing II.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld...

  20. Case managers' roles and functions: Commission for Case Manager Certification's 2004 research, part II.

    PubMed

    Tahan, Hussein A; Downey, William T; Huber, Diane L

    2006-01-01

    The Commission for Case Manager Certification (CCMC) conducted its third case managers' role and functions study in 2004 for the purpose of validating the currency and relevancy of the certified case manager examination. The results of this study are shared in an article of 2 parts. Part I, which was published in the previous issue of this journal, discussed the process the CCMC used for the development of the Case Managers' Role and Functions Survey Instrument and the identification of new 6 essential functions and 6 knowledge areas that describe case management practice. These findings were based on the survey of a large national sample of practicing case managers. Part II continues the analysis of the results and focuses on identifying the empirical (statistically derived) activity and knowledge domains of case management practice, using exploratory factor analysis. It discusses the similarities and differences found among various subgroups of case managers who were compared on the basis of certain demographic variables. In addition, Part II summarizes future changes in the field of case management as perceived by those who participated in the study. PMID:16582699

  1. Topics in Chemical Instrumentation, Cl. Thermoluminescence: Part II. Instrumentation.

    ERIC Educational Resources Information Center

    Manche, Emanuel P.

    1979-01-01

    Presents part two on the use of the detection of thermoluminescence as an analytical tool for the chemistry laboratory and allied science. This part discusses instrumentation used and investigates recent developments in instrumentation for thermoluminescence. (HM)

  2. Sporting Goods. Part I: Hunting and Fishing Equipment and Part II: Athletic, Marine, and Camping Equipment. A Distributive Education Manual.

    ERIC Educational Resources Information Center

    Day, Bill D., Comp.

    These manuals were prepared to introduce students to the fundamentals of hunting and fishing (Part I) and sports requiring athletic, marine and camping equipment (Part II). The sports salesman is in the position of offering a service to the customer, and he can best do so by understanding the sports and the variety of products which may be sold to…

  3. Coping With the Problems of a Technological Age, Part II.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

    This is another report in a series of programs dealing with the problems of a technological age. It is assumed that teachers will use both parts of this report. Part I deals with the problems of technology and how it affects our lives. It also discusses the energy crisis created, in part, by technology and deals specifically with coal and…

  4. From Student to Teacher: Making the Second Cut Part II

    ERIC Educational Resources Information Center

    Quezada, Reyes

    2005-01-01

    Part I of this two-part article, published in the March 2004 issue, addressed five components of the employment process in order to "make the first cut" when seeking a teaching position. The purpose of this article (Part two) is to provide teacher candidates with the necessary skills to understand and navigate the application process and on up to…

  5. Pulmonary physiology and the anesthetist--part II.

    PubMed

    Geelhoed, G W

    1980-04-01

    In part 1 of this three-part series, the author discussed the maintenance of cellular respiration and the function of the alveolar-capillary membrane. Part 2 deals with post-operative pulmonary problems, with a stress on the need to recognize and prevent these complications before their onset. PMID:7386135

  6. The Role of Regulatory Agencies and Intellectual Property: Part II.

    PubMed

    Noonan, Kevin E

    2015-07-01

    Patent law and antitrust law have traditionally been areas of the law involving at least some inherent tension. Champions of antitrust argue that the patent "monopoly" must be strictly limited as an exception to the general legal principle that competition should be unfettered. Patent lawyers argue that patents are the result of an exercise of congressional authority, enshrined in the Constitution, reflecting the policy decision by the Founders that granting a limited exclusionary right was justified by the public benefits derived from full disclosure of the patented invention. In the modern era these competing values have played out in the context of so-called ANDA litigation, involving disputes between branded pharmaceutical companies and generic competitors. Settlement of such litigation has been identified by the Federal Trade Commission (FTC), and private parties encouraged by the FTC's position, as an antitrust violation, in large part because such settlements are viewed as frustrating the congressional purpose in promoting early generic competition. After almost a decade of fighting these battles in the federal courts, the Supreme Court addressed the issue directly. The result is that such settlements are not per se illegal but are also not protected by the presumption of patent validity for activities within the "scope of the patent." Rather, the court decided that these agreements should be assessed for antitrust liability under the "rule of reason" used in other antitrust contexts. PMID:25775920

  7. A Conversation with William A. Fowler Part II

    NASA Astrophysics Data System (ADS)

    Greenberg, John

    2005-06-01

    Physicist William A.Fowler initiated an experimental program in nuclear astrophysics after World War II. He recalls here the Steady State versus Big Bang controversy and his celebrated collaboration with Fred Hoyle and Geoffrey and Margaret Burbidge on nucleosynthesis in stars. He also comments on the shift away from nuclear physics in universities to large accelerators and national laboratories.

  8. Part I. The fire properties of polymer clay nanocomposites. Part II. Thermal rearrangement of donor-acceptor substituted cyclopropanes

    NASA Astrophysics Data System (ADS)

    Su, Shengpei

    2003-08-01

    This work consists of two parts. Part I, which includes chapter 1--5, is focused on the fire properties of nanocomposites while part II deals with thermal rearrangement of the donor-acceptor cyclopropanes. In chapter 1 of the first part an introduction to the preparation of polymer-clay nanocomposites is provided along with their application to fire retardancy. Chapter 2 details the exfoliation process of clay using in situ polymerization; the results show that the exfoliation process is related to the monomer, the modified clay and the initiator. Chapter 3 concentrates on the preparation of nanocomposites by melt blending with polymer modified clays. Three different polymer modified clays (PS, PMMA and PBD modified clay) and six polymers (PS, HIPS, ABS, PMMA, PP and PE) are reported. The morphology, thermal stability, fire behavior and mechanical properties were studied. This research shows that the exfoliation process by melt blending is controlled by the types of interactions between the various polymers, the silicate surfaces and the organic modifier. The combination of polar polymer matrix and non-polar polymer modified clay with large d-spacing will be more likely to give the exfoliated nanocomposites. TGA-FTIR results show that the mechanism of degradation of polystyrene is changed in the presence of the clay. In order to better understand the effects of the organic modifier, PS surfactants with five different pendant groups, dimethylhexadecylamine, trimethylamine, dimethylbenzylamine, 1,2-dimethylimidizole and triphenylphosphine, were used and the results show that the degradation depends upon the pendant. Chapter 5 provides some suggestions for future work based upon this work. The synthesis of several new and previously reported donor-acceptor cyclopropanes is reported in part II. The study shows that the facility of the donor-acceptor cyclopropane ring cleavage is strongly influenced by the kind of activating substitutes on the cyclopropane ring, and the

  9. Overactive bladder – 18 years – Part II

    PubMed Central

    Truzzi, Jose Carlos; Gomes, Cristiano Mendes; Bezerra, Carlos A.; Plata, Ivan Mauricio; Campos, Jose; Garrido, Gustavo Luis; Almeida, Fernando G.; Averbeck, Marcio Augusto; Fornari, Alexandre; Salazar, Anibal; Dell’Oro, Arturo; Cintra, Caio; Sacomani, Carlos Alberto Ricetto; Tapia, Juan Pablo; Brambila, Eduardo; Longo, Emilio Miguel; Rocha, Flavio Trigo; Coutinho, Francisco; Favre, Gabriel; Garcia, José Antonio; Castaño, Juan; Reyes, Miguel; Leyton, Rodrigo Eugenio; Ferreira, Ruiter Silva; Duran, Sergio; López, Vanda; Reges, Ricardo

    2016-01-01

    ABSTRACT Traditionally, the treatment of overactive bladder syndrome has been based on the use of oral medications with the purpose of reestablishing the detrusor stability. The recent better understanding of the urothelial physiology fostered conceptual changes, and the oral anticholinergics – pillars of the overactive bladder pharmacotherapy – started to be not only recognized for their properties of inhibiting the detrusor contractile activity, but also their action on the bladder afference, and therefore, on the reduction of the symptoms that constitute the syndrome. Beta-adrenergic agonists, which were recently added to the list of drugs for the treatment of overactive bladder, still wait for a definitive positioning – as either a second-line therapy or an adjuvant to oral anticholinergics. Conservative treatment failure, whether due to unsatisfactory results or the presence of adverse side effects, define it as refractory overactive bladder. In this context, the intravesical injection of botulinum toxin type A emerged as an effective option for the existing gap between the primary measures and more complex procedures such as bladder augmentation. Sacral neuromodulation, described three decades ago, had its indication reinforced in this overactive bladder era. Likewise, the electric stimulation of the tibial nerve is now a minimally invasive alternative to treat those with refractory overactive bladder. The results of the systematic literature review on the oral pharmacological treatment and the treatment of refractory overactive bladder gave rise to this second part of the review article Overactive Bladder – 18 years, prepared during the 1st Latin-American Consultation on Overactive Bladder. PMID:27176185

  10. Cadenced IRAC Monitoring of Infrared-Variable AGNs, Part II

    NASA Astrophysics Data System (ADS)

    Ashby, Matthew; Fouesneau, Morgan; Hora, Joseph; Krick, Jessica; Smith, Howard; Surace, Jason

    2008-03-01

    We have analyzed IRAC imaging data from all 97 Spitzer visits to a very well-studied field, the IRAC Dark Calibration Field (IRAC-CF) near the north ecliptic pole. With this extensive dataset we have already identified a unique sample of 30 IR-variable galaxies which we are now working to characterize with respect to variability amplitudes and timescales, panchromatic SEDs, and host morphologies, among other quantities. Unfortunately, the continual change in spacecraft roll angle means that our sources are typically observed for at most six months at a time by each IRAC FOV in succession -- in other words, the visibility windows are exactly out of phase. Thus the existing data, despite the fact that they extend over more than four years, present large, unavoidable gaps that frustrate the time-delay analysis we wish to perform on exactly the timescales known to be common in active galaxies. This has only changed beginning in 2007 July: since that time cadenced IRAC observations have been carried out in synchrony with the IRAC-CF dark-calibration observations as part of our approved Cycle-4 program (PID 40553). Here we are proposing to continue this successful AGN monitoring campaign until the end of the cryogenic mission. The resulting timelines (covering 1500 days thus far and expected to run ultimately to some 2200+ days), will be a unique legacy of the Spitzer mission. This dataset, especially for the sizable, unbiased AGN sample we now have, holds unique promise for measuring the colors and temperatures of IR-varying AGN, and will have much to say about the underlying physical models of the infrared AGN emission. Accordingly we ask for just 8 h to gather IRAC photometry in the temporal gaps that would otherwise accrue in Cycle 5.

  11. Mathematics for Junior High School, Volume II (Part 2).

    ERIC Educational Resources Information Center

    Anderson, R. D.; And Others

    This is part two of a two-part SMSG mathematics text for junior high school students. Key ideas emphasized are structure of arithmetic from an algebraic viewpoint, the real number system as a progressing development, and metric and non-metric relations in geometry. Chapter topics include real numbers, similar triangles, variation, non-metric…

  12. Mathematics for Junior High School, Volume II (Part 1).

    ERIC Educational Resources Information Center

    Anderson, R. D.; And Others

    This is part one of a two-part SMSG mathematics text for junior high school students. Key ideas emphasized are structure of arithmetic from an algebraic viewpoint, the real number system as a progressing development, and metric and non-metric relations in geometry. Chapter topics include number line and coordinates, equations, scientific notation,…

  13. Reforming Science Education: Part II. Utilizing Kieran Egan's Educational Metatheory

    ERIC Educational Resources Information Center

    Schulz, Roland M.

    2009-01-01

    This paper is the second of two parts and continues the conversation which had called for a shift in the conceptual focus of science education towards philosophy of education, with the requirement to develop a discipline-specific "philosophy" of science education. In Part I, conflicting conceptions of science literacy were identified with…

  14. Selecting Instructional Materials: Part II. Matching Materials to Needs.

    ERIC Educational Resources Information Center

    Talmage, Harriet

    1981-01-01

    Presents a three-phase process for selecting instructional materials: (1) screening materials; (2) matching screened materials to identified district characteristics and needs; and (3) decision-making. Part I of this three-part article appeared in "Curriculum Review," January 1981, pp9-14. (SJL)

  15. Individualized Instruction in Teacher Education. Part I and II.

    ERIC Educational Resources Information Center

    Fall, Charles; And Others

    This two-part manual for college teachers of education is designed to provide information about individualized instruction along with resources for teaching a unit on it. Part 1, a general introduction to individualized instruction in teacher education, contains discussion of background historical development in the area of independent study;…

  16. Section II Part D and adoption of foreign materials

    SciTech Connect

    Gold, M.

    1995-12-01

    This paper describes the background, development, and structure of Section 2, Part D, of the ASME Boiler and Pressure Vessel Code. Section 2 deals with materials, and Part D, in particular, contains tables of design values of materials for use in conjunction with the construction sections of the Code: Sections 1, 3, and 8. The arrangement of Section 2, Part D, will be described with particular emphasis on how the allowable stress and design stress intensity tables are organized. Additionally, changes to Section 2, Part D that have been authorized, and are presently being implemented, will be discussed. These include the new policy decision to permit incorporation of materials from organizations other than ASTM and AWS, and particularly from International organizations; the adoption of a new Appendix to Section 2, Part D, addressing metallurgical phenomena that are important to the selection and application of materials in Code construction; and the decision to develop a new Appendix to address dual marking and material substitution.

  17. Design of site specific radiopharmaceuticals for tumor imaging. (Parts I and II)

    SciTech Connect

    Van Dort, M.E.

    1983-01-01

    Part I. Synthetic methods were developed for the preparation of several iodinated benzoic acid hydrazides as labeling moieties for indirect tagging of carbonyl-containing bio-molecules and potential tumor-imaging agents. Biodistribution studies conducted in mice on the derivatives having the I-125 label ortho to a phenolic OH demonstrated a rapid in vivo deiodination. Part II. The reported high melanin binding affinity of quinoline and other heterocyclic antimalarial drugs led to the development of many analogues of such molecules as potential melanoma-imaging agents. Once such analogue iodochloroquine does exhibit high melanin binding, but has found limited clinical use due to appreciable accumulation in non-target tissues such as the adrenal cortex and inner ear. This project developed a new series of candidate melanoma imaging agents which would be easier to radio-label, could yield higher specific activity product, and which might demonstrate more favorable pharmacokinetic and dosimetric characteristics compared to iodochloroquine.

  18. Internal Auditing in Federal, State, and Local Governments (Part II).

    ERIC Educational Resources Information Center

    Knight, Susan; Wilson, Guy

    1981-01-01

    This second part of an annotated bibliography of reports, books, and journal articles concerned with internal auditing in government contexts reviews the available literature for an understanding of the types of internal audit, methods and practices, and other facets. (FM)

  19. Designing SoTL Studies--Part II: Practicality

    ERIC Educational Resources Information Center

    Bartsch, Robert A.

    2013-01-01

    This chapter suggests solutions to common practical problems in designing SoTL studies. In addition, the advantages and disadvantages of different types of designs are discussed. [Part I available at EJ1029363.

  20. Astronomy Books of 1984: Part II--The Technical List.

    ERIC Educational Resources Information Center

    Fraknoi, Andrew

    1985-01-01

    An annotated bibliography of astronomy books is presented. These books (most of which are designed for research astronomers and graduate students) demand substantial background in astronomy and physics. Nontechnical books are reviewed in part I (SE 537 910). (JN)

  1. Conformational behavior of insect pheromones and analogues. Part II

    NASA Astrophysics Data System (ADS)

    Koča, Jaroslav; Carlsen, Per H. J.

    1992-04-01

    The conformational potential energy surface paths of the sex pheromone, Ipsenol, to the Bark Beetle, Ips typographus, and of a series of analogues have been elucidated using the program DAISY. The following structures were calculated: 2-methyl-6-methylene-7-octen-4-ol (Ipsenol, ( II)), 2-methyl-6-methylene-2,7-octadiene-4-ol acetate ( III), 2-methyl-6-methylene-3,7-octadien-2-ol ( IV), 2-methyl-6-methylene-1,7-octadien-3-ol ( V), 5-(3-furanyl)-2-methyl-1-penten-3-ol ( VI) and 1-(3-furanyl)-4-methyl-3-penten-2-ol ( VII). As a measure of the conformational flexibility of the molecules the flexibility coefficients, f, were determined. The f values for the molecules were determined to be: II, 0.145; III, 0.144; IV, 1.240; V, 0.133; VI, 0.825; and VII, 0.451. The molecular mechanics method was used for energy calculations in conjunction with DAISY. Low-energy conformations (conformational channels) together with energy barriers for conformational changes are presented.

  2. Mental Retardation Grants; Part II, Research and Demonstration. Fiscal Year 1968.

    ERIC Educational Resources Information Center

    Department of Health, Education, and Welfare, Washington, DC. Secretary's Committee on Mental Retardation.

    Part II of a two-part publication listing mental retardation grants awarded by the U.S. Department of Health, Education, and Welfare in fiscal year 1968 (July 1, 1967, to June 30, 1968), the text includes grants awarded in the areas of research and demonstration. (Part I covers grants in training and construction.) Grants are arranged according to…

  3. Operational strategies for dispatchable combined cycle plants, Part II

    SciTech Connect

    Nolan, J.P.; Landis, F.P.

    1996-11-01

    The Brush Cogeneration Facility is a dual-unit, combined cycle, cogeneration plant, operating in a dual cycling, automatically-dispatchable mode. Part I of this report described the contract, including automatic generation control (AGC) by Public Service Company of Colorado (PSCO), and the operation of Unit One. This part of the report covers the operation of Unit Two. Unit two is still in its operating infancy, but is showing that fuel efficiency and low emissions levels are not incompatible with cycling, load-following service. 1 fig.

  4. Karst geomorphology: From hydrological functioning to palaeoenvironmental reconstructions. Part II

    NASA Astrophysics Data System (ADS)

    De Waele, Jo; Gutierrez, Francisco; Audra, Philippe

    2015-10-01

    In January 2015, the first part of the special issue on karst, entitled "Karst geomorphology: From hydrological functioning to palaeoenvironmental reconstructions" was published (Geomorphology, Vol. 229). This second part of the special issue comprises seven research papers covering a broad geographical canvas including Japan, Slovenia, France, Spain, Croatia, and Poland-Ukraine. Both issues mainly emanate from the contributions presented in the Karst session of the 8th International Conference of Geomorphology (International Association of Geomorphologists), held in Paris in August 2013, enriched with some invited papers.

  5. Carbonic Anhydrase Inhibitors. Part 461 Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes

    PubMed Central

    Mincione, Giovanna; Scozzafava, Andrea

    1997-01-01

    Reaction of aromatic/heterocyclic sulfonamides containing a free amino group with triflic anhydride afforded compounds possessing trifluoromethanesulfonamido moieties in their molecule. The Zn(II) and Cu(II) complexes of these new sulfonamides were prepared and characterized by standard procedures (elemental analysis, spectroscopic, magnetic, thermogravimetric and conductimetric measurements). The new derivatives showed good inhibitory activity against three isozymes of carbonic anhydrase (CA), i.e., CA I, II and IV. PMID:18475762

  6. German women in chemistry, 1925-1945 (Part II).

    PubMed

    Johnson, J A

    1998-01-01

    The paper traces the role of German women into the chemistry profession from 1925 to 1945, examining their relative numbers and experience in higher education, in academic and industrial careers as well as in professional organizations such as the Verein Deutscher Chemikerinnen. The paper examines the effect of the 1930s Depression, National Socialism, and World War II on women chemists, considering both general trends as well as the experiences and achievements of several individual women in a variety of situations. Finally, it considers the longterm consequences of these developments, such as the Nazi expulsion of Jewish women, destruction of women's organizations and devaluing of women's achievements, in limiting the recognition and participation of German women chemists after 1945. PMID:11619995

  7. Today's Personal Computers: Products for Every Need--Part II.

    ERIC Educational Resources Information Center

    Personal Computing, 1981

    1981-01-01

    Looks at microcomputers manufactured by Altos Computer Systems, Cromemco, Exidy, Intelligent Systems, Intertec Data Systems, Mattel, Nippon Electronics, Northstar, Personal Micro Computers, and Sinclair. (Part I of this article, examining other computers, appeared in the May 1981 issue.) Journal availability: Hayden Publishing Company, 50 Essex…

  8. Finding Out about Archaeology: Parts I and II.

    ERIC Educational Resources Information Center

    Archaeological Inst. of America, Boston, MA.

    This packet of materials presents selected, descriptive bibliographies for children and young adults. Instructional materials for the use of teachers and parents are also included. Focusing on the subject of archaeology, part 1 of the annotated bibliography presents instructional materials coded for appropriate grade level use. Each entry…

  9. Solar Energy Education. Reader, Part II. Sun story. [Includes glossary

    SciTech Connect

    Not Available

    1981-05-01

    Magazine articles which focus on the subject of solar energy are presented. The booklet prepared is the second of a four part series of the Solar Energy Reader. Excerpts from the magazines include the history of solar energy, mythology and tales, and selected poetry on the sun. A glossary of energy related terms is included. (BCS)

  10. Kids in Mental Institutions. Part II. Program 131.

    ERIC Educational Resources Information Center

    George Washington Univ., Washington, DC. Inst. for Educational Leadership.

    The second of a two-part radio program on children in mental institutions presents transcripts of interviews with psychiatrists and emotionally disturbed adolescents. Subjects addressed include use of drugs, behavior modification, music, and theatre therapy in institutions. The transcript concludes with a narrated tour of Sheppard-Pratt, an…

  11. Searching for the Right Way to Begin Class: Part II

    ERIC Educational Resources Information Center

    Lawry, John D.

    2012-01-01

    Part I, "Searching for the Right Way to Begin Class," described the various iterations of beginning class rituals the author used over the years. Those rituals began with a prayer to the Holy Spirit as was required at the Catholic women's college Marymount in Tarrytown, New York, where he first taught out of graduate school in 1965. That was…

  12. Small Business Management. Part II. A Suggested Adult Course Outline.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Continuing Education Curriculum Development.

    This teacher's guide is a companion to "Small Business Management Part I" published by the New York State Education Department in 1968. The course outlined by the guide is primarily for those who aspire to own and operate their own business, and those in business who wish to improve their operations. The course consists of six lessons covering…

  13. Curriculum Guide for Hospitality Education. Part II. Exemplary Project.

    ERIC Educational Resources Information Center

    Kalani, Henry

    This second of a two-part study designed to develop a hospitality education program model for Hawaii's community colleges is based on the primary data gathered in a survey of the hospitality industry characteristics, manpower requirements, and employment demands. (Survey data is reported in volume 1 of the study.) The introductory section of this…

  14. Brief Internet and NREN Glossary: Part II (M-Z).

    ERIC Educational Resources Information Center

    Machovec, George S.

    1993-01-01

    Presents the second and final part of a selected glossary of terms commonly used in discussions relating to the Internet and the National Research and Education Network (NREN). Highlights include various network names; organizations; acronyms; user interfaces; network research testbeds; various protocols; remote login; and Wide Area Information…

  15. Accounting Clerk Guide, Exercise and Worksheet Packet--Part II.

    ERIC Educational Resources Information Center

    Foster, Brian; And Others

    The exercise and worksheet packet is part of an eight volume unit for grades 10, 11, and 12, designed for individualized progression in preparing students for entry into the occupation of accounting clerk. The exercise and worksheet packet contains a copy of every worksheet in the learner packet for lessons 12 through 21 so that the instructor can…

  16. Accounting Clerk Guide, Test Packet--Part II.

    ERIC Educational Resources Information Center

    Foster, Brian; And Others

    The test packet is part of an eight volume unit for grades 10, 11, and 12, designed for individualized progression in preparing the student for entry into the occupation of accounting clerk. The test packet contains both pretests and post-tests for lessons 12 through 21. The unit is concerned with the basic accounting theory as it is used in the…

  17. Laboratory Animal Housing--Parts I and II.

    ERIC Educational Resources Information Center

    Runkle, Robert S.

    1963-01-01

    In recent years, the use of laboratory animals for bio-medical research has shown marked increase. Economic and efficient housing is a necessity. This two part report established guidelines for design and selection of materials for conventional animal housing. Contents include--(1) production and breeding facilities, (2) quarantine facilities, (3)…

  18. A Methodology of Experience: Part II, The Process of Inquiry.

    ERIC Educational Resources Information Center

    Doll, William E., Jr.

    The first section of this paper which is the second on the same topic recapitulates the assessment of behavioral objectives originally stated in Part I, essentially to serve as a contrast to the "Dewey model" which states that goals should be determined "by" the students rather than "for" them, and hence that ends should not exist as fixed points…

  19. Summary of Gary Becker's IALL '93 Copyright Workshop, Part II.

    ERIC Educational Resources Information Center

    Starr, Irene

    1994-01-01

    This article covers the second part of a workshop on registering copyrighted materials, off-air video recording, using copyrighted videotapes in the classroom, and computer software copyright. The Copyright Law provides for the protection of the authors of creative works, while at the same time providing certain exemptions for educators and…

  20. Topics in Finance: Part II--Financial Analysis

    ERIC Educational Resources Information Center

    Laux, Judy

    2010-01-01

    The second article in a series designed to supplement the introductory financial management course, this essay addresses financial statement analysis, including its impact on stock valuation, disclosure, and managerial behavior. [For "Topics in Finance Part I--Introduction and Stockholder Wealth Maximization," see EJ1060345.

  1. Vint Cerf on the World Wide Web. Part II.

    ERIC Educational Resources Information Center

    Educom Review, 1996

    1996-01-01

    Presents the second part of an interview with Vinton Cerf on issues of information technology. Discusses reading with laptop computers; the "extinction" of books; technological experiments by publishers; copyrights, intellectual property, and ownership; cable companies; the impact of the Internet on education; and the future of the Internet. (AEF)

  2. Entrepreneurship Education and Training: Can Entrepreneurship Be Taught? Part II

    ERIC Educational Resources Information Center

    Henry, Colette; Hill, Frances; Leitch, Claire

    2005-01-01

    Purpose - Despite a growing body of literature in the field, there is still considerable uncertainty as to whether entrepreneurs are born are made, which has led to an ongoing debate in the entrepreneurship academy about whether we can actually teach individuals to be entrepreneurs. With this in mind, this two-part paper aims to address the…

  3. Aesthetic Pursuits: Windows, Frames, Words, Images--Part II

    ERIC Educational Resources Information Center

    Burke, Ken

    2005-01-01

    In Part I of this study (Burke, 2005), the author presented the essentials of Image Presentation Theory--IPT--and its application to the analytical explication of various spatial designs in and psychological responses to images, from the illusions of depth in what is referred to as "windows" in cinema theory to the more patterned abstractions of…

  4. AEE's Report on the Insurance Issue: Part II.

    ERIC Educational Resources Information Center

    Marlow, Peggy

    1986-01-01

    Sixty-three outdoor adventure programs were reviewed to research the availability of general liability insurance for outdoor programs. Data were gathered on populations served, activities, insurer, and amount of general liability coverage. Three companies offered policies with high risk activity exclusions. Alternative ways to provide for…

  5. Delivery systems for biopharmaceuticals. Part II: Liposomes, Micelles, Microemulsions and Dendrimers.

    PubMed

    Silva, Ana C; Lopes, Carla M; Lobo, José M S; Amaral, Maria H

    2015-01-01

    Biopharmaceuticals are a generation of drugs that include peptides, proteins, nucleic acids and cell products. According to their particular molecular characteristics (e.g. high molecular size, susceptibility to enzymatic activity), these products present some limitations for administration and usually parenteral routes are the only option. To avoid these limitations, different colloidal carriers (e.g. liposomes, micelles, microemulsions and dendrimers) have been proposed to improve biopharmaceuticals delivery. Liposomes are promising drug delivery systems, despite some limitations have been reported (e.g. in vivo failure, poor long-term stability and low transfection efficiency), and only a limited number of formulations have reached the market. Micelles and microemulsions require more studies to exclude some of the observed drawbacks and guarantee their potential for use in clinic. According to their peculiar structures, dendrimers have been showing good results for nucleic acids delivery and a great development of these systems during next years is expected. This is the Part II of two review articles, which provides the state of the art of biopharmaceuticals delivery systems. Part II deals with liposomes, micelles, microemulsions and dendrimers. PMID:26278524

  6. Part I. Mechanisms of injury associated with extracorporeal shock wave lithotripsy; Part II. Exsolution of volatiles

    NASA Astrophysics Data System (ADS)

    Howard, Danny Dwayne

    Part I - Shock waves are focused in extracorporeal shock wave lithotripsy (ESWL) machines to strengths sufficient to fracture kidney stones. Substantial side effects-most of them acute-have resulted from this procedure, including injury to soft tissue. The focusing of shock waves through various layers of tissue is a complex process which stimulates many bio-mechano-chemical responses.This thesis presents results of an in vitro study of the initial mechanical stimulus. Planar nitrocellulose membranes of order 10 um thick were used as models of thin tissue structures. Two modes of failure were recorded: Failure due to cavitation collapsing on or near the membranes, and failure induced by altering the structure of shock waves. Tests were done in water at and around F2 to characterize the extent of cavitation damage, and was found to be confined within the focal region, 1.2 cm along the axis of focus.Scattering media were used to simulate the effects of acoustic nonuniformity of tissue and to alter the structure of focusing shock waves. 40 um diameter (average) hollow glass spheres were added to ethylene glycol, glycerine and castor oil to vary the properties of the scattering media. Multiple layer samples of various types of phantom tissue were tested in degassed castor oil to gauge the validity of the scattering media. The scattering media and tissue samples increased the rise time decreased strain rate in a similar fashion. Membranes were damaged by the decreased strain rate and accumulated effects of the altered structure: After about 20 or so shocks immersed in the scattering media and after about 100 shocks behind the tissue samples. The mode of failure was tearing with multiple tears in some cases from about .1 cm to about 3 cm depending of the number of shocks and membrane thickness.Part II - This work examines the exsolution of volatiles-carbon dioxide from water-in a cylindrical test cell under different pressure conditions. Water was supersaturated with

  7. Fourier Transform Infrared Spectroscopy: Part II. Advantages of FT-IR.

    ERIC Educational Resources Information Center

    Perkins, W. D.

    1987-01-01

    This is Part II in a series on Fourier transform infrared spectroscopy (FT-IR). Described are various advantages of FT-IR spectroscopy including energy advantages, wavenumber accuracy, constant resolution, polarization effects, and stepping at grating changes. (RH)

  8. GSTARS computer models and their applications, Part II: Applications

    USGS Publications Warehouse

    Simoes, F.J.M.; Yang, C.T.

    2008-01-01

    In part 1 of this two-paper series, a brief summary of the basic concepts and theories used in developing the Generalized Stream Tube model for Alluvial River Simulation (GSTARS) computer models was presented. Part 2 provides examples that illustrate some of the capabilities of the GSTARS models and how they can be applied to solve a wide range of river and reservoir sedimentation problems. Laboratory and field case studies are used and the examples show representative applications of the earlier and of the more recent versions of GSTARS. Some of the more recent capabilities implemented in GSTARS3, one of the latest versions of the series, are also discussed here with more detail. ?? 2008 International Research and Training Centre on Erosion and Sedimentation and the World Association for Sedimentation and Erosion Research.

  9. Achieving hemostasis in dermatology-Part II: Topical hemostatic agents

    PubMed Central

    Glick, Jaimie B.; Kaur, Ravneet R.; Siegel, Daniel

    2013-01-01

    Bleeding is a common occurrence during any dermatologic surgery that disrupts blood vessels. The complications of excess bleeding can include delayed wound healing, hematoma formation, infection, dehiscence, and necrosis. In part one of this review, we discussed the pre-operative, intra-operative, and post-operative management of patients undergoing dermatologic surgery. In Part two, we discuss traditional and new topical hemostatic agents used to achieve hemostasis in dermatological procedures and surgery. We will evaluate the caustic and non-caustic hemostatic agents as well as hemostatic dressings. The mechanisms of action, side effect profile, and advantages and disadvantages of the topical hemostatic agents are provided. Sources for this article were found searching the English literature in PubMed for the time period 1940 to March 2012. A thorough bibliography search was also performed and key references examined. PMID:23984226

  10. SnapShot: SMC Protein Complexes Part II.

    PubMed

    Haering, Christian H; Gruber, Stephan

    2016-02-11

    This second of two SnapShots on SMC proteins depicts their roles at different stages of the eukaryotic cell cycle. The composition and architecture of SMC protein complexes and their regulators appear in SMC Protein Complexes Part I (available at http://www.cell.com/cell/pdf/S0092-8674%2815%2901690-6.pdf). To view this SnapShot, open or download the PDF. PMID:26871638

  11. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part II.

    PubMed

    Sidhu, P S; Brabrand, K; Cantisani, V; Correas, J M; Cui, X W; D'Onofrio, M; Essig, M; Freeman, S; Gilja, O H; Gritzmann, N; Havre, R F; Ignee, A; Jenssen, C; Kabaalioğlu, A; Lorentzen, T; Mohaupt, M; Nicolau, C; Nolsøe, C P; Nürnberg, D; Radzina, M; Saftoiu, A; Serra, C; Spârchez, Z; Sporea, I; Dietrich, C F

    2015-12-01

    This is the second part of the series on interventional ultrasound guidelines of the Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB). It deals with the diagnostic interventional procedure. General points are discussed which are pertinent to all patients, followed by organ-specific imaging that will allow the correct pathway and planning for the interventional procedure. This will allow for the appropriate imaging workup for each individual interventional procedure (Long version). PMID:26669871

  12. Variance analysis. Part II, The use of computers.

    PubMed

    Finkler, S A

    1991-09-01

    This is the second in a two-part series on variance analysis. In the first article (JONA, July/August 1991), the author discussed flexible budgeting, including the calculation of price, quantity, volume, and acuity variances. In this second article, the author focuses on the use of computers by nurse managers to aid in the process of calculating, understanding, and justifying variances. PMID:1919788

  13. Hermeneutics as an approach to science: Part II

    NASA Astrophysics Data System (ADS)

    Eger, Martin

    1993-12-01

    This paper continues the hermeneutic-phenomenological investigation of natural science, in which understanding plays a role comparable to creative construction (see ‘Hermeneutics as an Approach to Science: Part I’ in Science & Education 2(1)). The first issue treated is that of language: Is the language of science part of the equipment of the scientist, the subject, or part of the object itself — nature already linguistically encased? This issue, arising from the so-called argument of ‘the double hermeneutic’, relates the general question of the role of the subject in natural science to the role of interpretation. Examples of major interpretative developments in physics are discussed. The inquiry suggests that the role of interpretation and hermeneutics is tied to the educative or ‘study-mode’ of science; and that this mode can, apparently, be found at all levels and stages of science. The nature of this interpretive mode, and its relation to the creative mode, is then analyzed on the model of Gadamer's description of the interpretation of art.

  14. Slag Behavior in Gasifiers. Part II: Constitutive Modeling of Slag

    SciTech Connect

    Massoudi, Mehrdad; Wang, Ping

    2013-02-07

    The viscosity of slag and the thermal conductivity of ash deposits are among two of the most important constitutive parameters that need to be studied. The accurate formulation or representations of the (transport) properties of coal present a special challenge of modeling efforts in computational fluid dynamics applications. Studies have indicated that slag viscosity must be within a certain range of temperatures for tapping and the membrane wall to be accessible, for example, between 1,300 °C and 1,500 °C, the viscosity is approximately 25 Pa·s. As the operating temperature decreases, the slag cools and solid crystals begin to form. Since slag behaves as a non-linear fluid, we discuss the constitutive modeling of slag and the important parameters that must be studied. We propose a new constitutive model, where the stress tensor not only has a yield stress part, but it also has a viscous part with a shear rate dependency of the viscosity, along with temperature and concentration dependency, while allowing for the possibility of the normal stress effects. In Part I, we reviewed, identify and discuss the key coal ash properties and the operating conditions impacting slag behavior.

  15. Targeted maximum likelihood based causal inference: Part II.

    PubMed

    van der Laan, Mark J

    2010-01-01

    In this article, we provide a template for the practical implementation of the targeted maximum likelihood estimator for analyzing causal effects of multiple time point interventions, for which the methodology was developed and presented in Part I. In addition, the application of this template is demonstrated in two important estimation problems: estimation of the effect of individualized treatment rules based on marginal structural models for treatment rules, and the effect of a baseline treatment on survival in a randomized clinical trial in which the time till event is subject to right censoring. PMID:21731531

  16. Targeted Maximum Likelihood Based Causal Inference: Part II

    PubMed Central

    van der Laan, Mark J.

    2010-01-01

    In this article, we provide a template for the practical implementation of the targeted maximum likelihood estimator for analyzing causal effects of multiple time point interventions, for which the methodology was developed and presented in Part I. In addition, the application of this template is demonstrated in two important estimation problems: estimation of the effect of individualized treatment rules based on marginal structural models for treatment rules, and the effect of a baseline treatment on survival in a randomized clinical trial in which the time till event is subject to right censoring. PMID:21731531

  17. Cancer Chemotherapy: Past, Present, and Future—Part II

    PubMed Central

    Wright, Jane C.

    1984-01-01

    Cancer is of major concern today because of its high mortality. It is estimated that 66 million people in this country will eventually develop cancer; 1983 estimates were 855,000 new cases and 440,000 deaths from cancer. Because of limitations of surgery and radiation therapy in effecting a cure for cancer, chemotherapy has become increasingly important. The developments in the chemical control of cancer in man are encouraging. This two-part paper* covers the historical milestones in the development of the chemical and hormonal control of cancer, present successes with the use of polychemotherapy, and the hopeful trend in research. PMID:6492179

  18. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part II.

    PubMed

    Sidhu, P S; Brabrand, K; Cantisani, V; Correas, J M; Cui, X W; D'Onofrio, M; Essig, M; Freeman, S; Gilja, O H; Gritzmann, N; Havre, R F; Ignee, A; Jenssen, C; Kabaalioğlu, A; Lorentzen, T; Mohaupt, M; Nicolau, C; Nolsøe, C P; Nürnberg, D; Radzina, M; Saftoiu, A; Serra, C; Spârchez, Z; Sporea, I; Dietrich, C F

    2015-12-01

    This is the second part of the series on interventional ultrasound guidelines of the Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB). It deals with the diagnostic interventional procedure. General points are discussed which are pertinent to all patients, followed by organ-specific imaging that will allow the correct pathway and planning for the interventional procedure. This will allow for the appropriate imaging workup for each individual interventional procedure (Long version/ short version; the long version is published online). PMID:26669869

  19. The museum maze in oral pathology demystifed: part II.

    PubMed

    Patil, Shankargouda; Rao, Roopa S; Ganavi, Bs

    2013-01-01

    Museum technology is perpetually changing due to current requirements and added inventions for our comfort and furbished display of specimens. Hence numerous methods of specimen preservation have been put on trial by diverse people in the medical feld as are the inventions. But only few have caught people's interest and are popularized today. This part provides unique insights into specialized custom-made techniques, evolution of recent advances like plastination and virtual museum that have popularized as visual delights. Plastination gives handy, perennial life-like acrylic specimens, whereas virtual museum takes museum feld to the electronic era making use of computers and virtual environment. PMID:24685810

  20. The Solar Ultraviolet Spectrum Estimated Using the Mg II K Index and Ca II K disk Activity

    NASA Astrophysics Data System (ADS)

    McMullin, D. R.; Morrill, J. S.; Floyd, L. E.

    2010-12-01

    As part of a program to estimate the solar spectrum backward in time to the early twentieth century, we have generated fits to UV spectral irradiance measurements (150 - 410 nm) as a function of two solar activity proxies, the Mg II core-to-wing ratio, or Mg II index, and the total Ca II K disk activity derived from ground based observations. In addition, irradiance spectra at shorter wavelengths (1 - 150 nm) where used to generate fits to the Mg II core-to-wing ratio alone. Two sets of spectra were used in these fitting procedures. The fits at longer wavelengths (150 to 410 nm) were based on the high resolution spectra taken by the Solar Ultraviolet Spectral Irradiance Monitor (SUSIM) on the Upper Atmospheric Research Satellite (UARS). Spectra measured by the Solar EUV Experiment (SEE) instrument on the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellite were used for the fits at wavelengths from 1 to 150 nm. To generate fits between solar irradiance and solar proxies, this study uses the above irradiance data, the NOAA composite Mg II index, and daily Ca II K disk activity determined from images measured by Big Bear Solar Observatory (BBSO). Among the results of this study is an estimated relationship between the fraction of the disk with enhanced Ca II K activity and the Mg II index, an upper bound of the average solar UV spectral irradiance during periods of pure quiet sun as was believed to be present during the Maunder Minimum, and results indicating that more than 60 % of the Total Solar Irradiance (TSI) variability occurs between 150 and 400nm. In this presentation we will discuss the results of this study and the implications for estimating UV spectra for use in long-term climate models.

  1. Histologic features of alopecias: part II: scarring alopecias.

    PubMed

    Bernárdez, C; Molina-Ruiz, A M; Requena, L

    2015-05-01

    The diagnosis of disorders of the hair and scalp can generally be made on clinical grounds, but clinical signs are not always diagnostic and in some cases more invasive techniques, such as a biopsy, may be necessary. This 2-part article is a detailed review of the histologic features of the main types of alopecia based on the traditional classification of these disorders into 2 major groups: scarring and nonscarring alopecias. Scarring alopecias are disorders in which the hair follicle is replaced by fibrous scar tissue, a process that leads to permanent hair loss. In nonscarring alopecias, the follicles are preserved and hair growth can resume when the cause of the problem is eliminated. In the second part of this review, we describe the histologic features of the main forms of scarring alopecia. Since a close clinical-pathological correlation is essential for making a correct histopathologic diagnosis of alopecia, we also include a brief description of the clinical features of the principal forms of this disorder. PMID:25439143

  2. Higher Education and Older People: Some Theoretical Considerations, Part II.

    ERIC Educational Resources Information Center

    Covey, Herbert C.

    1983-01-01

    Describes disengagement, activity, lifespan, subcultural, and continuity theories of social gerontology in light of participation in higher education by older students. Argues that continuity theory holds the most promise in accounting for older students. Emphasizes the need to stress the positive roles of old age. (JAC)

  3. Civic Virtue, Social Justice and Catholic Schools: Part II.

    ERIC Educational Resources Information Center

    Ognibene, Richard; Paulli, Kenneth

    2002-01-01

    Details the history of the Catholic Church's involvement in social justice issues from the Second Vatican Council (1962-65) on. Describes social justice programs in schools in the diocese of Albany, New York, as well as other programs. Stresses that social justice activity rises out gratitude for the gift of life and should be seen in the context…

  4. Marine Biology and Oceanography, Grades Nine to Twelve. Part II.

    ERIC Educational Resources Information Center

    Kolb, James A.

    This unit, one of a series designed to develop and foster an understanding of the marine environment, presents marine science activities for students in grades 9-12. The unit, focusing on sea plants/animals and their interactions with each other and the non-living environment, has sections dealing with: marine ecology; marine bacteriology;…

  5. Planar LTCC transformers for high voltage flyback converters: Part II.

    SciTech Connect

    Schofield, Daryl; Schare, Joshua M., Ph.D.; Slama, George; Abel, David

    2009-02-01

    This paper is a continuation of the work presented in SAND2007-2591 'Planar LTCC Transformers for High Voltage Flyback Converters'. The designs in that SAND report were all based on a ferrite tape/dielectric paste system originally developed by NASCENTechnoloy, Inc, who collaborated in the design and manufacturing of the planar LTCC flyback converters. The output/volume requirements were targeted to DoD application for hard target/mini fuzing at around 1500 V for reasonable primary peak currents. High voltages could be obtained but with considerable higher current. Work had begun on higher voltage systems and is where this report begins. Limits in material properties and processing capabilities show that the state-of-the-art has limited our practical output voltage from such a small part volume. In other words, the technology is currently limited within the allowable funding and interest.

  6. Iterative phase retrieval algorithms. Part II: Attacking optical encryption systems.

    PubMed

    Guo, Changliang; Liu, Shi; Sheridan, John T

    2015-05-20

    The modified iterative phase retrieval algorithms developed in Part I [Guo et al., Appl. Opt.54, 4698 (2015)] are applied to perform known plaintext and ciphertext attacks on amplitude encoding and phase encoding Fourier-transform-based double random phase encryption (DRPE) systems. It is shown that the new algorithms can retrieve the two random phase keys (RPKs) perfectly. The performances of the algorithms are tested by using the retrieved RPKs to decrypt a set of different ciphertexts encrypted using the same RPKs. Significantly, it is also shown that the DRPE system is, under certain conditions, vulnerable to ciphertext-only attack, i.e., in some cases an attacker can decrypt DRPE data successfully when only the ciphertext is intercepted. PMID:26192505

  7. Responsive Persistence Part II. Practices of Postmodern Therapists.

    PubMed

    Sutherland, Olga; Dienhart, Anna; Turner, Jean

    2013-10-01

    This article, a companion to Part I of this series of articles, discusses how therapists informed by social constructionist and postmodern ideas enact persistence in their work with families. Transcripts and video-recordings of therapy interaction facilitated by selected major champions for three postmodern (collaborative) therapies: Michael White (narrative therapy), Harlene Anderson (collaborative language systems approach), and Bill O'Hanlon (solution-oriented therapy) were examined for persistence practices. The article offers a range of possible ways in which postmodern therapists may enact their influence in facilitating generative and helpful conversations with families and remain responsive to clients' preferences and understandings. Implications for family therapy practice, training, and supervision are discussed. PMID:25800424

  8. Renewable energy in Hawaii lessons learned, Part II

    SciTech Connect

    Greer, L.S.; Hubbard, H.M.; Bloyd, C.N.

    1995-12-31

    Hawaii`s extensive renewable resources, limited access to conventional fuels, and its isolated electrical grids all combine to provide an opportunity to clearly observe the development and implementation of renewable energy processes, technologies, and materials. Hawaii is distinctive in its electrical power usage since it is an island chain with isolated grid systems that range in size from less than 5 Megawatts to over 1.5 Gigawatts and also has many off grid dwellings and at least one isolated village system. However, it has been noted that lessons learned from Hawaii`s early experiences in trying to utilize renewable energy have a great deal in common with problems encountered by mainland utilities trying to do the same thing. Furthermore, conditions in Hawaii are very similar to those in many tropical and semitropical locations in the Pacific and Southeast Asia. Hence, Hawaii`s renewable energy experience is shared here in the hope that it may prove useful to others. This review is the second part of a two part series that describes the progress of renewable energy in the state of Hawaii. The steps taken in Hawaii with regards to ocean thermal energy conversion (OTEC), wave energy, photovoltaics (PV), solar thermal water heating, hydroelectric, and geothermal technologies over the past 20 years are reviewed. Conclusions drawn from Hawaii`s renewable energy experience are summarized in a list of lessons learned that are provided for the interest of those who may be carrying out similar efforts in other locations. 64 refs., 3 figs., 7 tabs.

  9. Medicine at the crossroads. Part II. Summary of completed project

    SciTech Connect

    1998-05-01

    Medicine at the crossroads (a.k.a. The Future of Medicine) is an 8-part series of one-hour documentaries which examines the scientific and social forces that have shaped the practice of medicine around the world. The series was developed and produced over a five-year period and in eleven countries. Among the major issues examined in the series are the education of medical practitioners and the communication of medical issues. The series also considers the dilemmas of modern medicine, including the treatment of the elderly and the dying, the myth of the quick fix in the face of chronic and incurable diseases such as HIV, and the far-reaching implications of genetic treatments. Finally, the series examines the global progress made in medical research and application, as well as the questions remaining to be answered. These include not only scientific treatment, but accessibility and other critical topics affecting the overall success of medical advances. Medicine at the crossroads is a co-production of Thirteen/WNET and BBC-TV in association with Television Espafiola SA (RTVE) and the Australian Broadcasting Corporation. Stefan Moore of Thirteen/WNET and Martin Freeth of BBC-TV are series producers. George Page is executive in charge of medicine at the crossroads. A list of scholarly advisors and a program synopses is attached.

  10. Spectroscopic signatures of PETN: Part II. Detection in clay

    NASA Astrophysics Data System (ADS)

    Ballesteros-Rueda, Luz Marina; Herrera-Sandoval, Gloria M.; Mina, Nairmen; Castro-Rosario, Miguel E.; Briano, Julio G.; Hernandez-Rivera, Samuel P.

    2006-05-01

    Infrared Spectroscopy is a well established tool for standoff detection of chemical agents in military applications. Vibrational IR spectroscopic analysis can also be used in Chemical Point Detection mode and to the arena of explosives identification and detection when energetic compounds are in contact with soil. PETN is an important nitroaliphatic explosive for military applications. Due to its intrinsic explosive power, it can be used in laminar form or mixed with RDX to manufacture Semtex plastic explosive and in the fabrication of Improvised Explosive Devices (IEDs). This investigation focused on the study of spectroscopic signatures of PETN in contact with soil. For this study, clay was mixed in different proportions with PETN. Detection of the vibrational signatures of PETN constitutes the central part of the investigation. The mixtures were submitted to the effect of water, acid and alkaline solutions, heat and deep UV light (234 nm) in order to establish the effect on these environmental parameters on the vibrational signatures of the explosive in the mixtures. The results reveal that the characteristic bands of PETN are highly persisted, degraded only by extreme conditions of UV radiation and exposure to high temperature for prolonged time. These results could be used in the development of sensitive sensors for detection of landmines, and improvised explosives devices (IDEs).