Note: This page contains sample records for the topic partial safety analysis from Science.gov.
While these samples are representative of the content of Science.gov,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of Science.gov
to obtain the most current and comprehensive results.
Last update: November 12, 2013.
1

Modeling of partial flooding for criticality safety analysis  

SciTech Connect

Accidental exposure of fuel to water is often an important concern in criticality safety. This is the result of the effectiveness of water as a reflecting material and especially as a neutron moderating material. Even a low effective water density, such as that produced by fire protection sprinklers, is sometimes sufficient to produce a large reactivity increase relative to dry fuel. Also, the peak reactivity can occur when the water exposure is far below the maximum possible. For these reasons, it is necessary to consider all plausible water exposure possibilities when assessing the criticality safety of fuel. This paper explores approaches for modeling the partial flooding of stored fuel.

Schaefer, R.W. [Argonne National Lab., Idaho Falls, ID (United States)

1999-09-01

2

Partial Safety Analysis for a Reduced Uranium Enrichment Core for the High Flux Isotope Reactor  

SciTech Connect

A computational model of the reactor core of the High Flux Isotope Rector (HFIR) was developed in order to analyze non-destructive accidents caused by transients during reactor operation. The reactor model was built for the latest version of the nuclear analysis software package called Program for the Analysis of Reactor Transients (PARET). Analyses performed with the model constructed were compared with previous data obtained with other tools in order to benchmark the code. Finally, the model was used to analyze the behavior of the reactor under transients using a different nuclear fuel with lower enrichment of uranium (LEU) than the fuel currently used, which has a high enrichment of uranium (HEU). The study shows that the presence of fertile isotopes in LEU fuel, which increases the neutron resonance absorption, reduces the impact of transients on the fuel and enhances the negative reactivity feedback, thus, within the limitations of this study, making LEU fuel appear to be a safe alternative fuel for the reactor core.

Primm, Trent [ORNL; Gehin, Jess C [ORNL

2009-04-01

3

West side, oblique, partially hidden by trees, utility safety fence, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

West side, oblique, partially hidden by trees, utility safety fence, and the deep shadow of the 1962 annex. View to northeast. - San Bernardino Valley College, Library, 701 South Mount Vernon Avenue, San Bernardino, San Bernardino County, CA

4

Physics analysis of the gang partial rod drive event  

SciTech Connect

During the routine positioning of partial-length control rods in Gang 3 on the afternoon of Monday, July 27, 1992, the partial-length rods continued to drive into the reactor even after the operator released the controlling toggle switch. In response to this occurrence, the Safety Analysis and Engineering Services Group (SAEG) requested that the Applied Physics Group (APG) analyze the gang partial rod drive event. Although similar accident scenarios were considered in analysis for Chapter 15 of the Safety Analysis Report (SAR), APG and SAEG conferred and agreed that this particular type of gang partial-length rod motion event was not included in the SAR. This report details this analysis.

Boman, C.; Frost, R.L.

1992-08-01

5

Safety assessment and caloric value of partially hydrolyzed guar gum.  

PubMed

Guar gum and partially hydrolyzed guar gum (PHGG) are food ingredients that have been available for many years. PHGG is the partially hydrolyzed product from guar gum obtained from the Indian cluster bean (Cyanopsis tetragonolopus). The gum (CAS Registry No. 9000-30-0) is composed of galactomannan, a gel-forming polysaccharide with a molecular weight ranging from 200 to 300 kDa. The intact and partially hydrolyzed forms have multiple food applications. The intact material can be used to control the viscosity, stability, and texture of foods. PHGG is highly soluble and has little physical impact on foods. Both forms are indigestible but are excellent sources of fermentable dietary fiber. The caloric value of intact guar gum is accepted as 2.0, whereas the caloric value of PHGG has not been firmly established. It is the goal of this paper to review the chemistry, safety, in vivo effects, and caloric value of PHGG. PMID:23347282

Finley, John W; Soto-Vaca, Adriana; Heimbach, James; Rao, T P; Juneja, Lekh Raj; Slavin, Joanne; Fahey, George C

2013-02-12

6

Software safety hazard analysis  

SciTech Connect

Techniques for analyzing the safety and reliability of analog-based electronic protection systems that serve to mitigate hazards in process control systems have been developed over many years, and are reasonably well understood. An example is the protection system in a nuclear power plant. The extension of these techniques to systems which include digital computers is not well developed, and there is little consensus among software engineering experts and safety experts on how to analyze such systems. One possible technique is to extend hazard analysis to include digital computer-based systems. Software is frequently overlooked during system hazard analyses, but this is unacceptable when the software is in control of a potentially hazardous operation. In such cases, hazard analysis should be extended to fully cover the software. A method for performing software hazard analysis is proposed in this paper.

Lawrence, J.D. [Lawrence Livermore National Lab., CA (United States)

1996-02-01

7

CONVEYOR SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose and objective of this analysis is to systematically identify and evaluate hazards related to the Yucca Mountain Project Exploratory Studies Facility (ESF) surface and subsurface conveyor system (for a list of conveyor subsystems see section 3). This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the conveyor structures/systems/components in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the structure/system/component (S/S/C) design, (2) add safety devices and capabilities to the designs that reduce risk, (3) provide devices that detect and warn personnel of hazardous conditions, and (4) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions. The scope of this analysis is limited to the hazards related to the design of conveyor structures/systems/components (S/S/Cs) that occur during normal operation. Hazards occurring during assembly, test and maintenance or ''off normal'' operations have not been included in this analysis. Construction related work activities are specifically excluded per DOE Order 5481.1B section 4. c.

M. Salem

1995-06-23

8

Safety analysis and review system  

SciTech Connect

Westinghouse Savannah River Company (WSRC) has developed a comprehensive Safety Analysis and Review System that satisfies Department of Energy safety analysis report requirements. This system consists of interrelated criteria for hazard classification, risk assessment, selection of Safety Class Items (SCIs), and selection of Operational Safety Requirements (OSRs). The system provides input for design decisions at appropriate project milestones as required by the life cycle of a project. The criteria used for selection in hazard classification, risk assessment, Safety Class Items (SCI) identification, and Operational Safety Requirement (OSR) identification are the subject of this paper.

Hallinan, E.J.; Donner, E.B.; Low, J.M.; Cowen, M.L.; Stephens, K.W.; Waltz, W.R.; Kim, K.S.

1992-01-01

9

Safety analysis and review system  

SciTech Connect

Westinghouse Savannah River Company (WSRC) has developed a comprehensive Safety Analysis and Review System that satisfies Department of Energy safety analysis report requirements. This system consists of interrelated criteria for hazard classification, risk assessment, selection of Safety Class Items (SCIs), and selection of Operational Safety Requirements (OSRs). The system provides input for design decisions at appropriate project milestones as required by the life cycle of a project. The criteria used for selection in hazard classification, risk assessment, Safety Class Items (SCI) identification, and Operational Safety Requirement (OSR) identification are the subject of this paper.

Hallinan, E.J.; Donner, E.B.; Low, J.M.; Cowen, M.L.; Stephens, K.W.; Waltz, W.R.; Kim, K.S.

1992-07-01

10

Comparing safety analysis techniques  

Microsoft Academic Search

In process industry Safety Instrumented Systems (SIS) and Emergency Shutdown Systems (ESD) are very important for the management\\/reduction of risk. In new standards (e.g. Ref. [1]) on functional safety of electrical\\/electronic\\/programmable electronic safety-related systems a quantification of the achieved safety is often required. These new standards do not prescribe how to calculate the achieved safety. Only guidelines and recommendations are

J. L Rouvroye; E. G van den Bliek

2002-01-01

11

49 CFR 229.307 - Safety analysis.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 false Safety analysis. 229.307 Section...Electronics § 229.307 Safety analysis. (a) A railroad shall develop a Safety Analysis (SA) for each product...that a product's safety-critical functions will...

2012-10-01

12

Partial wave analysis using graphics processing units  

Microsoft Academic Search

Partial wave analysis is an important tool for determining resonance properties in hadron spectroscopy. For large data samples however, the un-binned likelihood fits employed are computationally very expensive. At the Beijing Spectrometer (BES) III experiment, an increase in statistics compared to earlier experiments of up to two orders of magnitude is expected. In order to allow for a timely analysis

Niklaus Berger; Liu Beijiang; Wang Jike

2010-01-01

13

B PLANT DOCUMENTED SAFETY ANALYSIS  

SciTech Connect

This document provides the documented safety analysis (DSA) and Central Plateau Remediation Project (CP) requirements that apply to surveillance and maintenance (S&M) activities at the 221-B Canyon Building and ancillary support structures (B Plant). The document replaces BHI-010582, Documented Safety Analysis for the B-Plant Facility. The B Plant is non-operational, deactivated and undergoing long term S&M prior to decontamination and decommissioning (D&D). This DSA is compliant with 10 CFR 830, Nuclear Safety Management, Subpart B, ''Safety Basis Requirements.'' The DSA was developed in accordance with U.S. Department of Energy (DOE) standard DOE-STD-1120-98, Integration of Environment, Safety, and Health into Facility Disposition Activities (DOE 1998) per Table 2 of 10 CFR 830 Appendix A, DOE Richland Operation Office (RL) direction (02-ABD-0053, Fluor Hanford Nuclear Safety Basis Strategy and Criteria) for facilities in long term S&M, and RL Direction (02-ABD-0091, ''FHI Nuclear Safety Expectations for Nuclear Facilities in Surveillance and Maintenance''). A crosswalk was prepared to identify potential inconsistencies between the previous B Plant safety analysis and DOE-STD-1120-98 guidance. In general, the safety analysis met the criteria of DOE-STD-1120-98. Some format and content changes have been made, including incorporating recent facility modifications and updating the evaluation guidelines and control selection criteria in accordance with RL direction (02-ABD-0053). The facility fire hazard analysis (FHA) and Technical Safety Requirements (TSR) are appended to this DSA as an aid to the users, to minimize editorial redundancy, and to provide an efficient basis for update.

DODD, E.N.; KERR, N.R.

2003-08-01

14

Partially Premixed Flame (PPF) Research for Fire Safety.  

National Technical Information Service (NTIS)

Incipient fires typically occur after the partial premixing of fuel and oxidizer. The mixing of product species into the fuel/oxidizer mixture influences flame stabilization and fire spread. Therefore, it is important to characterize the impact of differe...

I. K. Puri S. K. Aggarwal A. J. Lock U. Hegde

2004-01-01

15

Measuring Safety Performance: A Comparison of Whole, Partial, and Momentary Time-Sampling Recording Methods  

ERIC Educational Resources Information Center

Partial-interval (PIR), whole-interval (WIR), and momentary time sampling (MTS) estimates were compared against continuous measures of safety performance for three postural behaviors: feet, back, and shoulder position. Twenty-five samples of safety performance across five undergraduate students were scored using a second-by-second continuous…

Alvero, Alicia M.; Struss, Kristen; Rappaport, Eva

2008-01-01

16

From Safety Analysis to Software Requirements  

Microsoft Academic Search

Software for safety critical systems must deal with the hazards identified by safety analysis. This paper investigates, how the results of one safety analysis technique, fault trees, are interpreted as software safety requirements to be used in the program design process. We propose that fault tree analysis and program development use the same system model. This model is formalized in

Kirsten Mark Hansen; Victoria Stavridou

1998-01-01

17

Procedure Analysis for Robot System Safety.  

National Technical Information Service (NTIS)

Several robot system safety techniques were reviewed and a procedure analysis was presented for the planning, installation, and operation stages of adding a robot to the workplace. The analysis covered safety measures that should be taken, risks of not ta...

B. C. Jiang O. S. H. Cheng

1991-01-01

18

Systems engineered health and safety criteria for safety analysis reports  

SciTech Connect

The world of safety analysis is filled with ambiguous words: codes and standards; consequences and risks; hazard and accident, and health and safety. These words have been subject to disparate interpretations by Safety Analysis Report (SAR) writers, readers and users. ``Principal health and safety criteria`` has been one of the most frequently misused terms; rarely is it used consistently or effectively. This paper offers an easily understood definition for ``principal health and safety criteria,`` and uses systems engineering to convert an otherwise mysterious topic into the primary means of producing an integrated SAR. This paper is based upon SARs being written for Environmental Restoration & Waste Management activities for the Department of Energy (DOE). Requirements for these SARs are prescribed in DOE Order 5480.23, ``Nuclear Safety Analysis Reports``.

Beitel, G.A.; Morcos, N.

1993-08-01

19

Regularized Partial and/or Constrained Redundancy Analysis  

ERIC Educational Resources Information Center

Methods of incorporating a ridge type of regularization into partial redundancy analysis (PRA), constrained redundancy analysis (CRA), and partial and constrained redundancy analysis (PCRA) were discussed. The usefulness of ridge estimation in reducing mean square error (MSE) has been recognized in multiple regression analysis for some time,…

Takane, Yoshio; Jung, Sunho

2008-01-01

20

The effect of partial stroke testing on the reliability of safety valves  

Microsoft Academic Search

Safety instrumented systems (SIS) are used to protect against conse- quences of hazardous events in the oil and gas industry. It is important to detect failures that may impede the SIS from performing upon demands. Re- cently,partialstroketestinghasbeenintroducedasanautomaticmeanstotest the SIS valves. Partial stroke testing is able to detect failuresthat traditionally have been revealed by function testing without causing process disturbances. Unfortunately,authorshavedifferentviews

M. A. Lundteigen; M. Rausand

2007-01-01

21

Partial genome analysis of murine gammaherpesvirus 4556.  

PubMed

Murine gammaherpesvirus 68 (MHV-68) -infected mouse is an animal model of gammaherpesvirus infection in man and domestic animals. Murine gammaherpesvirus 4556 (MHV-4556), isolated from Apodemus flavicollis ticks has been considered a close relative of MHV-68 but different in some features of infection in vitro and in vivo. Previous comparison of MHV-4556 with MHV-68 has revealed their diversity in immune evasion protein MK3. In this study, HindIII and EcoRI restriction profiles of the MHV-4556 genome disclosed absence of the deletion that has been identified previously at the left end of genomes of murine gammaherpesvirus 76 (MHV-76) and murine gammaherpesvirus Šumava (MHV-Šumava). A 22, 565 bp portion of MHV-4556 genome sequence was sequenced, analyzed and compared with that of MHV-68. Nucleotide sequences of 21 genes of MHV-4556 and deduced amino acid sequences revealed their identity to those of MHV-68 except for differences in 15 nucleotides and 8 amino acids in 5 genes and their proteins, respectively. Due to these differences, immune evasion protein M4 and structural proteins encoded by ORF8 (gB), ORF11 (p43), ORF26 and ORF52, respectively, are predicted to have a reduced hydrophilicity and surface exposure compard with their MHV-68 counterparts. These differences obviously contribute to some different pathogenetical features of these viruses and could explain the weaker immunogenicity of MHV-4556 in comparison with MHV-68. Keywords: murine gammaherpesvirus 4556; restriction analysis; partial genome sequence. PMID:23043597

Kúdelová, M; Halásová, Z; Belvon?íková, P; Pan?ík, P; Režuchová, I; Valovi?ová, M

2012-01-01

22

Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeutics  

PubMed Central

Purpose Electronic healthcare databases are commonly used in comparative effectiveness and safety research of therapeutics. Many databases now include additional confounder information in a subset of the study population through data linkage or data collection. We described and compared existing methods for analyzing such datasets. Methods Using data from The Health Improvement Network and the relation between non-steroidal anti-inflammatory drugs (NSAIDs) and upper gastrointestinal bleeding (UGIB) as an example, we employed several methods to handle partially missing confounder information. Results The crude odds ratio (OR) of upper gastrointestinal bleeding was 1.50 (95% confidence interval: 0.98, 2.28) among selective cyclo-oxygenase-2 inhibitor initiators (n = 43,569) compared with traditional non-steroidal anti-inflammatory drug initiators (n = 411,616). The OR dropped to 0.81 (0.52, 1.27) upon adjustment for confounders recorded for all patients. When further considering three additional variables missing in 22% of the study population (smoking, alcohol consumption, body mass index), the OR was between 0.80 and 0.83 for the missing-category approach, the missing-indicator approach, single imputation by the most common category, multiple imputation by chained equations, and propensity score calibration. The OR was 0.65 (0.39, 1.09) and 0.67 (0.38, 1.16) for the unweighted and the inverse probability weighted complete-case analysis, respectively. Conclusion Existing methods for handling partially missing confounder data require different assumptions and may produce different results. The unweighted complete-case analysis, the missing-category/indicator approach, and single imputation require often unrealistic assumptions and should be avoided. In this study, differences across methods were not substantial, likely due to relatively low proportion of missingness and weak confounding effect by the three additional variables upon adjustment for other variables.

Toh, Sengwee; Rodriguez, Luis A. Garcia; Hernan, Miguel A.

2013-01-01

23

SIMMER as a safety analysis tool  

SciTech Connect

SIMMER has been used for numerous applications in fast reactor safety, encompassing both accident and experiment analysis. Recent analyses of transition-phase behavior in potential core disruptive accidents have integrated SIMMER testing with the accident analysis. Results of both the accident analysis and the verification effort are presented as a comprehensive safety analysis program.

Smith, L.L.; Bell, C.R.; Bohl, W.R.; Bott, T.F.; Dearing, J.F.; Luck, L.B.

1982-01-01

24

Assuring the quality of safety analyses and safety analysis documentation  

SciTech Connect

Planning, preparation, and submittal of safety analysis reports might be pursued in a manner similar to a quality-related procurement, where customer needs, expectations and acceptance criteria are established in advance. Then the product/service provider, the contractor, should apply various quality control processes to assure the desired characteristics of the product safety analysis documents. Improving the quality and acceptability to DOE of safety documents at first submittal should result in a more expeditious DOE review and approval process, thereby reducing costs of network and recycle through reviews.

J. E. Johnson

2000-05-03

25

Assuring the Quality of Safety Analyses and Safety Analysis Documentation  

SciTech Connect

Planning, preparation, and submittal of safety analysis reports might be pursued in a manner similar to a quality-related procurement, where customer needs, expectations and acceptance criteria are established in advance. Then the product/service provider, the contractor, should apply various quality control processes to assure the desired characteristics of the product safety analysis documents. Improving the quality and acceptability to DOE of safety documents at first submittal should result in a more expeditious DOE review and approval process, thereby reducing costs of network and recycle through reviews.

Johnson, John Edwin

2000-05-01

26

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2010 CFR

... 2009-01-01 2009-01-01 false Flight safety limits analysis. 417.213 Section 417...TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.213 Flight safety limits analysis. (a) General. A...

2009-01-01

27

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2010 CFR

... 2010-01-01 2010-01-01 false Flight safety limits analysis. 417.213 Section 417...TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.213 Flight safety limits analysis. (a) General. A...

2010-01-01

28

Geometric Partial Differential Equations and Image Analysis  

Microsoft Academic Search

This book provides an introduction to the use of geometric partial differential equations in image processing and computer vision. It brings a number of new concepts into the field, providing a very fundamental and formal approach to image processing. State-of-the-art practical results in a large number of real problems are achieved with the techniques described. Applications covered include image segmentation,

Guillermo Sapiro

2001-01-01

29

Methodology of independent software nuclear safety analysis  

Microsoft Academic Search

Independent software nuclear safety analysis provides a methodology to ensure that software does not cause or contribute to a violation of the nuclear safety standards established by the Department of Defense, and that nuclear safety-critical software is not adversely affected by interfacing software or by operator action. This methodology is a systematic approach to examine a specific aspect of software

Edward A. Addy

1994-01-01

30

Risk-analysis procedures ensure system safety  

Microsoft Academic Search

Conducting risk analysis and safety- engineering studies before construction of a sour-gas pipeline system will build redundancies into the system and ensure safe operation and maintenance. A recent analysis of a sour-gas pipeline built in Texas provides an example of procedures for safety engineering and risk assessment. This first of two articles presents the risk-analysis methodology and minimum safety systems

M. Mannan; D. B. Pfenning; C. D. Zinn

1991-01-01

31

Radiation safety content guide for safety analysis reports  

SciTech Connect

US Department of Energy-Savannah River Operations Office (DOE-SR) facilities develop Safety Analysis Reports (SARs) to permit evaluation of potential hazards to the health and safety of the public and employees and potential hazards to government property and the environment. The SAR is the primary vehicle by which the Operating Contractor provides information to demonstrate that the facility can be operated safely. The Savannah River Operations Office independently reviews SARs to determine their technical integrity and completeness. In order to make the review process most efficient, SARs must be prepared in a consistent manner and contain all required information. This document provides guidance on the content of the radiation safety information to be included in SARs. It is not within the scope of this guide to address the entire Safety Analysis Report. 53 refs.

Not Available

1989-08-01

32

Preliminary Integrated Safety Analysis Status Report  

SciTech Connect

This report provides the status of the potential Monitored Geologic Repository (MGR) Integrated Safety Analysis (EA) by identifying the initial work scope scheduled for completion during the ISA development period, the schedules associated with the tasks identified, safety analysis issues encountered, and a summary of accomplishments during the reporting period. This status covers the period from October 1, 2000 through March 30, 2001.

D. Gwyn

2001-04-01

33

Hot Cell Facility (HCF) Safety Analysis Report  

SciTech Connect

This Safety Analysis Report (SAR) is prepared in compliance with the requirements of DOE Order 5480.23, Nuclear Safety Analysis Reports, and has been written to the format and content guide of DOE-STD-3009-94 Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Safety Analysis Reports. The Hot Cell Facility is a Hazard Category 2 nonreactor nuclear facility, and is operated by Sandia National Laboratories for the Department of Energy. This SAR provides a description of the HCF and its operations, an assessment of the hazards and potential accidents which may occur in the facility. The potential consequences and likelihood of these accidents are analyzed and described. Using the process and criteria described in DOE-STD-3009-94, safety-related structures, systems and components are identified, and the important safety functions of each SSC are described. Additionally, information which describes the safety management programs at SNL are described in ancillary chapters of the SAR.

MITCHELL,GERRY W.; LONGLEY,SUSAN W.; PHILBIN,JEFFREY S.; MAHN,JEFFREY A.; BERRY,DONALD T.; SCHWERS,NORMAN F.; VANDERBEEK,THOMAS E.; NAEGELI,ROBERT E.

2000-11-01

34

Deterministic and Probabilistic Approach to Safety Analysis.  

National Technical Information Service (NTIS)

The examples discussed in this paper show that reliability analysis methods fairly well can be applied in order to interpret deterministic safety criteria in quantitative terms. For further improved extension of applied reliability analysis it has turned ...

F. W. Heuser

1980-01-01

35

Probabilistic safety analysis procedures guide  

Microsoft Academic Search

A procedures guide for the performance of probabilistic safety assessment has been prepared for interim use in the Nuclear Regulatory Commission programs. The probabilistic safety assessment studies performed are intended to produce probabilistic predictive models that can be used and extended by the utilities and by NRC to sharpen the focus of inquiries into a range of tissues affecting reactor

I. A. Papazoglou; R. A. Bari; A. J. Buslik; R. E. Hall; D. Ilberg; P. K. Samanta; T. Teichmann; R. W. Youngblood; A. El-Bassioni; J. Fragola

1984-01-01

36

PRINCIPAL COMPONENTS ANALYSIS AND PARTIAL LEAST SQUARES REGRESSION  

EPA Science Inventory

The mathematics behind the techniques of principal component analysis and partial least squares regression is presented in detail, starting from the appropriate extreme conditions. he meaning of the resultant vectors and many of their mathematical interrelationships are also pres...

37

Plutonium Uranium Extraction Facility Documented Safety Analysis  

SciTech Connect

This document provides the documented safety analysis (DSA) and Central Plateau Remediation Project (CP) requirements that apply to surveillance and maintenance (S&M) activities at the Plutonium-Uranium Extraction (PUREX) facility. This DSA was developed in accordance with DOE-STD-1120-98, ''Integration of Environment, Safety, and Health into Facility Disposition Activities''. Upon approval and implementation of this document, the current safety basis documents will be retired.

DODD, E.N.

2003-10-08

38

Safety Analysis and Related Studies.  

National Technical Information Service (NTIS)

Several examples of reactor safety studies are given. For light water reactors, the consequences of loss of coolant, the disposition of the fuel elements and the behaviour under irradiation of the steels used for containment are described. For fast reacto...

J. Lelievre

1979-01-01

39

Contracting for Safety: A Concept Analysis  

Microsoft Academic Search

The concept of contracting for safety, although a popularly accepted method for managing suicidal patients, has no scientific evidence to support its effectiveness. There are questions regarding the clinical justification. This article provides a concept analysis of contracting for safety to evolve and clarify exemplary criteria of the concept within psychiatric nursing practice. At times in clinical practice, contracting is

Mary P. Egan

1997-01-01

40

HANFORD SAFETY ANALYSIS & RISK ASSESSMENT HANDBOOK (SARAH)  

SciTech Connect

The purpose of the Hanford Safety Analysis and Risk Assessment Handbook (SARAH) is to support the development of safety basis documentation for Hazard Category 2 and 3 (HC-2 and 3) U.S. Department of Energy (DOE) nuclear facilities to meet the requirements of 10 CFR 830, ''Nuclear Safety Management''. Subpart B, ''Safety Basis Requirements.'' Consistent with DOE-STD-3009-94, Change Notice 2, ''Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'' (STD-3009), and DOE-STD-3011-2002, ''Guidance for Preparation of Basis for Interim Operation (BIO) Documents'' (STD-3011), the Hanford SARAH describes methodology for performing a safety analysis leading to development of a Documented Safety Analysis (DSA) and derivation of Technical Safety Requirements (TSR), and provides the information necessary to ensure a consistently rigorous approach that meets DOE expectations. The DSA and TSR documents, together with the DOE-issued Safety Evaluation Report (SER), are the basic components of facility safety basis documentation. For HC-2 or 3 nuclear facilities in long-term surveillance and maintenance (S&M), for decommissioning activities, where source term has been eliminated to the point that only low-level, residual fixed contamination is present, or for environmental remediation activities outside of a facility structure, DOE-STD-1120-98, ''Integration of Environment, Safety, and Health into Facility Disposition Activities'' (STD-1120), may serve as the basis for the DSA. HC-2 and 3 environmental remediation sites also are subject to the hazard analysis methodologies of this standard.

EVANS, C.B.

2004-12-21

41

DAM SAFETY RISK ASSESSMENT WITH UNCERTAINTY ANALYSIS  

Microsoft Academic Search

The use of uncertainty analysis in conjunction with risk assessment provides enhanced information for decision makers. Uncertainties in risk analysis inputs are propagated through the risk analysis and evaluation steps of risk assessment to obtain estimates of the level of confidence in the risk assessment outcomes. This paper presents a framework for uncertainty analysis in dam safety risk assessment, including

Sanjay S. Chauhan; David S. Bowles

2003-01-01

42

10 CFR 830.206 - Preliminary documented safety analysis.  

Code of Federal Regulations, 2013 CFR

...DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis...category 1, 2, or 3 DOE nuclear facility must: ...preliminary documented safety analysis for the facility...approval of: (1) The nuclear safety design criteria to...

2013-01-01

43

Autoclave nuclear criticality safety analysis  

SciTech Connect

Steam-heated autoclaves are used in gaseous diffusion uranium enrichment plants to heat large cylinders of UF{sub 6}. Nuclear criticality safety for these autoclaves is evaluated. To enhance criticality safety, systems are incorporated into the design of autoclaves to limit the amount of water present. These safety systems also increase the likelihood that any UF{sub 6} inadvertently released from a cylinder into an autoclave is not released to the environment. Up to 140 pounds of water can be held up in large autoclaves. This mass of water is sufficient to support a nuclear criticality when optimally combined with 125 pounds of UF{sub 6} enriched to 5 percent U{sup 235}. However, water in autoclaves is widely dispersed as condensed droplets and vapor, and is extremely unlikely to form a critical configuration with released UF{sub 6}. 4 refs., 3 figs.

D`Aquila, D.M. [Portsmouth Gaseous Diffusion Plant, OH (United States); Tayloe, R.W. Jr. [Battelle, Columbus, OH (United States)

1991-11-19

44

Quantitative NMR Analysis of Partially Substituted Biodiesel Glycerols  

SciTech Connect

Phosphitylation of hydroxyl groups in biodiesel samples with 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane followed by 31P-NMR analysis provides a rapid quantitative analytical technique for the determination of substitution patterns on partially esterified glycerols. The unique 31P-NMR chemical shift data was established with a series mono and di-substituted fatty acid esters of glycerol and then utilized to characterize an industrial sample of partially processed biodiesel.

Nagy, M.; Alleman, T. L.; Dyer, T.; Ragauskas, A. J.

2009-01-01

45

Qualitative Analysis of Partially-observable Markov Decision Processes  

Microsoft Academic Search

We study observation-based strategies for partially-observable Markov decision processes(POMDPs) with parity objectives. An observation- based strategy relies on partial information about the hist ory of a play, namely, on the past sequence of observations. We consider qualitative analysis prob- lems: given a POMDP with a parity objective, decide whether there exists an observation-based strategy to achieve the objective with probability

Krishnendu Chatterjee; Laurent Doyen; Thomas A. Henzinger

2009-01-01

46

Nuclear Criticality Safety Analysis of Isostatic Press.  

National Technical Information Service (NTIS)

In response to your request a nuclear criticality safety analysis was done for the isostatic press for conditions that were specified. Under normal conditions the press is subcritical by a large margin. It is considered remotely possible, however, that th...

H. K. Clark

1988-01-01

47

Using Addenda in Documented Safety Analysis Reports  

SciTech Connect

This paper discusses the use of addenda to the Radioactive Waste Management Complex (RWMC) Documented Safety Analysis (DSA) located at the Idaho National Engineering and Environmental Laboratory (INEEL). Addenda were prepared for several systems and processes at the facility that lacked adequate descriptive information and hazard analysis in the DSA. They were also prepared for several new activities involving unreviewed safety questions (USQs). Ten addenda to the RWMC DSA have been prepared since the last annual update.

Swanson, D.S.; Thieme, M.A.

2003-06-16

48

Using Addenda in Documented Safety Analysis Reports  

SciTech Connect

This paper discusses the use of addenda to the Radioactive Waste Management Complex (RWMC) Documented Safety Analysis (DSA) located at the Idaho National Engineering and Environmental Laboratory (INEEL). Addenda were prepared for several systems and processes at the facility that lacked adequate descriptive information and hazard analysis in the DSA. They were also prepared for several new activities involving unreviewed safety questions (USQs). Ten addenda to the RWMC DSA have been prepared since the last annual update.

Douglas S. Swanson; Michael A. Thieme

2003-06-01

49

Methodology for System Safety Analysis.  

National Technical Information Service (NTIS)

This standard tailors and interprets certain requirements of MIL-STD-1574 and defines the methodology to be used to satisfy the analytical requirements imposed by that MIL Standard. The system safety analyses required by MIL-STD-1574 normally take the for...

1977-01-01

50

Safety analysis of a microgrid  

Microsoft Academic Search

Microgrids are attracting substantial interest because they have the potential to increase the use of renewable generation and micro-CHP. They can also defer investment in distribution capital plant and can improve local power quality. However the primary operational requirement of power systems is that they must operate safely from a user point of view, even during contingencies. Yet electrical safety

N. Jayawarna; N. Jenkins; M. Barnes; M. Lorentzou; S. Papthanassiou; N. Hatziagyriou

2005-01-01

51

Active learning of plans for safety and reachability goals with partial observability.  

PubMed

Traditional planning assumes reachability goals and/or full observability. In this paper, we propose a novel solution for safety and reachability planning with partial observability. Given a planning domain, a safety property, and a reachability goal, we automatically learn a safe permissive plan to guide the planning domain so that the safety property is not violated and that can force the planning domain to eventually reach states that satisfy the reachability goal, regardless of how the planning domain behaves. Our technique is based on the active learning of regular languages and symbolic model checking. The planning method first learns a safe plan using the L (*) algorithm, which is an efficient active learning algorithm for regular languages. We then check whether the safe plan learned is also permissive by Alternating-time Temporal Logic (ATL) model checking. If the plan is permissive, it is indeed a safe permissive plan. Otherwise, we identify and add a safe string to converge a safe permissive plan. We describe an implementation of the proposed technique and demonstrate that our tool can efficiently construct safe permissive plans for four sets of examples. PMID:19661004

Nam, Wonhong; Alur, Rajeev

2009-08-04

52

Overview of Energy Systems` safety analysis report programs. Safety Analysis Report Update Program  

SciTech Connect

The primary purpose of an Safety Analysis Report (SAR) is to provide a basis for judging the adequacy of a facility`s safety. The SAR documents the safety analyses that systematically identify the hazards posed by the facility, analyze the consequences and risk of potential accidents, and describe hazard control measures that protect the health and safety of the public and employees. In addition, some SARs document, as Technical Safety Requirements (TSRs, which include Technical Specifications and Operational Safety Requirements), technical and administrative requirements that ensure the facility is operated within prescribed safety limits. SARs also provide conveniently summarized information that may be used to support procedure development, training, inspections, and other activities necessary to facility operation. This ``Overview of Energy Systems Safety Analysis Report Programs`` Provides an introduction to the programs and processes used in the development and maintenance of the SARs. It also summarizes some of the uses of the SARs within Energy Systems and DOE.

Not Available

1992-03-01

53

Road Safety: Accident Analysis And Reconstruction  

Microsoft Academic Search

This work focuses, in this first phase, on accident analysis and reconstruction, with the purpose of devoting a second phase on the analysis of risk levels. The present paper defines synthetically the analysis of procedures and methodologies related to poor safety conditions, turning in the last part in a applicative example. Since the year 2000, a certain number of accidents

G. e Sillo

54

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2013 CFR

14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Flight safety limits analysis...213 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...LICENSING LAUNCH SAFETY Flight Safety Analysis §...

2013-01-01

55

10 CFR 70.62 - Safety program and integrated safety analysis.  

Code of Federal Regulations, 2013 CFR

...program and integrated safety analysis. 70...70.62 Energy NUCLEAR REGULATORY COMMISSION...Critical Mass of Special Nuclear Material § 70.62 Safety program and integrated...have experience in nuclear criticality safety, radiation...

2013-01-01

56

SAFEGUARDS AND SECURITY INTEGRATION WITH SAFETY ANALYSIS  

SciTech Connect

The objective of this paper is to share the Savannah River Site lessons learned on Safeguards and Security (S&S) program integration with K-Area Complex (KAC) safety basis. The KAC Documented Safety Analysis (DSA), is managed by the Washington Savannah River Company (WSRC), and the S&S program, managed by Wackenhut Services, Incorporated--Savannah River Site (WSI-SRS). WSRC and WSI-SRS developed a contractual arrangement to recognize WSI-SRS requirements in the KAC safety analysis. Design Basis Threat 2003 (DBT03) security upgrades required physical modifications and operational changes which included the availability of weapons which could potentially impact the facility safety analysis. The KAC DSA did not previously require explicit linkage to the S&S program to satisfy the safety analysis. WSI-SRS have contractual requirements with the Department of Energy (DOE) which are separate from WSRC contract requirements. The lessons learned will include a discussion on planning, analysis, approval of the controls and implementation issues.

Hearn, J; James Lightner, J

2007-04-13

57

Improving safety through root cause analysis  

Microsoft Academic Search

Operations at the US Department of Energy -- Savannah River Site (SRS) include such diverse facilities as reactors, fuel fabrication, chemical processing, coal burning power houses, analytical laboratories and research facilities. To enhance the safety of operations at SRS, a Root Cause Analysis process has been developed and is discussed in this document. Root Cause Analysis is a three-step process

J. L. Gatlin; K. Taylor

1991-01-01

58

Integrated safety analysis of requirements specifications  

Microsoft Academic Search

This paper describes an integrated approach to safety analysis of software requirements and demonstrates the feasibility and utility of applying the individual techniques and the integrated approach on the requirements specification of a guidance system for a high-speed civil transport being developed at NASA Ames. Each analysis found different types of errors in the specification; thus together the techniques provided

Francesmary Modugno; Nancy G. Leveson; Jon D. Reese; Kurt Partridge; Sean D. Sandys

1997-01-01

59

Linear vibration analysis of cantilever plates partially submerged in fluid  

Microsoft Academic Search

Dynamic characteristics, such as natural frequencies and mode shapes, of cantilever plates, partially in contact with a fluid, are investigated. In the analysis of the linear fluid–structure system, it is assumed that the fluid is ideal, and fluid forces are associated with inertial effects of the surrounding fluid. This implies that the fluid pressure on the wetted surface of the

A. Ergin; B. Ugurlu

2003-01-01

60

Fréchet sensitivity analysis for partial differential equations with distributed parameters  

Microsoft Academic Search

This paper reviews Fr´ echet sensitivity analysis for partial differential equations with variations in distributed parameters. The Fr´ echet derivative provides a linear map be- tween parametric variations and the linearized response of the solution. We propose a methodology based on representations of the Frderivative operator to find those variations that lead to the largest changes to the solution (the

Jeff Borggaard; Vitor Leite Nunes

2011-01-01

61

TRIAGE DOSE ASSESSMENT FOR PARTIAL-BODY EXPOSURE: DICENTRIC ANALYSIS  

PubMed Central

Partial-body biodosimetry is likely to be required after a radiological or nuclear exposure. Clinical signs and symptoms, distribution of dicentrics in circulating blood cells, organ-specific biomarkers, physical signals in teeth and nails all can provide indications of non-homogeneous exposures. Organ specific biomarkers may provide early warning regarding physiological systems at risk after radiation injury. Use of a combination of markers and symptoms will be needed for clinical insights for therapeutic approaches. Analysis of dicentrics, a marker specific for radiation injury, is the “Gold standard” of biodosimetry and can reveal partial-body exposures. Automation of sample processing for dicentric analysis can increase throughput with customization of off-the-shelf technologies for cytogenetic sample processing and information management. Automated analysis of the metaphase spreads is currently limited but improvements are in development. Our efforts bridge the technological gaps to allow the use of dicentric chromosome assay (DCA) for risk-based stratification of mass casualties. This article summarizes current knowledge on partial-body cytogenetic dose assessment synthesizing information leading to the proposal of an approach to triage dose prediction in radiation mass casualties, based on equivalent whole-body doses under partial-body exposure conditions and assesses the validity of using this model. An initial screening using only 20 metaphase spreads per subject can confirm irradiation above 2-Gy. A subsequent increase to 50 metaphases improves dose determination to allow risk stratification for clinical triage. Metaphases evaluated for inhomogeneous distribution of dicentrics can reveal partial-body exposures. We tested the validity of this approach in an in vitro model that simulates partial-body irradiation by mixing irradiated and un-irradiated lymphocytes in various proportions. Our preliminary results support the notion that this approach will be effective under a range of conditions including some partial-body exposures, but may have limitations with low doses or small proportions of irradiated body. Our studies address an important problem in the diagnosis of partial-body irradiation and dose assessment in mass casualties and propose a solution. However, additional work is needed to fully develop and validate the application of DCA to partial-body exposures.

Moroni, Maria; Pellmar, Terry C.

2009-01-01

62

Divalproex sodium in children with partial seizures: 12-month safety study.  

PubMed

This phase III, open-label, multicenter, outpatient study evaluated the 12-month safety of valproate using divalproex sodium sprinkle capsules for partial seizures, with or without secondary generalization, in children aged 3-10 years (n = 169). Laboratory parameters and vital signs were assessed, and the Wechsler Scales of Intelligence, the Developmental Profile-II, movement-related items from the Udvalg for Kliniske Undersøgelser, and the Behavior Assessment System for Children were administered. Efficacy was measured by the 4-week seizure rate. The most common treatment-emergent adverse events in the 169 study patients were typical childhood illnesses: pyrexia (18%), cough (17%), and nasopharyngitis (14%). The most common adverse events not considered typical childhood illnesses were vomiting (14%), tremor (9%), somnolence (8%), and diarrhea (8%). Of the 169 patients, 11 (6.5%) were hospitalized with serious treatment-emergent adverse events. Although elevated ammonia levels were observed in 31 treated patients, and mean increases in uric acid concentrations and decreases in platelets were observed, the majority of patients were asymptomatic. Except for tremor, no increases in movement-related adverse effects were observed. Small numeric improvements were reported in the Wechsler Scales and the Behavior Assessment System for Children. The safety findings in this 12-month study are generally consistent with previous reports of valproate in adult and pediatric epilepsy patients. PMID:19589457

Lenz, Robert A; Elterman, Roy D; Robieson, Weining Z; Vigna, Namita V; Saltarelli, Mario D

2009-08-01

63

Presurgical multimodality neuroimaging analysis for complex partial seizures  

NASA Astrophysics Data System (ADS)

Surgical treatment of patients suffering from complex partial seizures requires the localization of the epileptogenic zone for surgical resection. Currently, clinicians utilize electroencephalography (EEG), psychological tests, and various neuroimaging modalities together to determine the location of this zone. We investigate the use of positron emission tomography (PET), magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS) in the presurgical workup and analysis of patients with complex partial seizures. The results of imaging studies of 25 patients are compared for lateralization accuracy and relative concordance.

Wong, Stephen T.; Soo Hoo, Kent; Knowlton, Robert C.; Laxer, Kenneth D.; Hawkins, Randall A.; Rowley, Howard A.; Weiner, Michael W.

1998-07-01

64

K West integrated water treatment system subproject safety analysis document  

SciTech Connect

This Accident Analysis evaluates unmitigated accident scenarios, and identifies Safety Significant and Safety Class structures, systems, and components for the K West Integrated Water Treatment System.

SEMMENS, L.S.

1999-02-24

65

Waste Isolation Pilot Plant Safety Analysis Report  

SciTech Connect

The following provides a summary of the specific issues addressed in this FY-95 Annual Update as they relate to the CH TRU safety bases: Executive Summary; Site Characteristics; Principal Design and Safety Criteria; Facility Design and Operation; Hazards and Accident Analysis; Derivation of Technical Safety Requirements; Radiological and Hazardous Material Protection; Institutional Programs; Quality Assurance; and Decontamination and Decommissioning. The System Design Descriptions`` (SDDS) for the WIPP were reviewed and incorporated into Chapter 3, Principal Design and Safety Criteria and Chapter 4, Facility Design and Operation. This provides the most currently available final engineering design information on waste emplacement operations throughout the disposal phase up to the point of permanent closure. Also, the criteria which define the TRU waste to be accepted for disposal at the WIPP facility were summarized in Chapter 3 based on the WAC for the Waste Isolation Pilot Plant.`` This Safety Analysis Report (SAR) documents the safety analyses that develop and evaluate the adequacy of the Waste Isolation Pilot Plant Contact-Handled Transuranic Wastes (WIPP CH TRU) safety bases necessary to ensure the safety of workers, the public and the environment from the hazards posed by WIPP waste handling and emplacement operations during the disposal phase and hazards associated with the decommissioning and decontamination phase. The analyses of the hazards associated with the long-term (10,000 year) disposal of TRU and TRU mixed waste, and demonstration of compliance with the requirements of 40 CFR 191, Subpart B and 40 CFR 268.6 will be addressed in detail in the WIPP Final Certification Application scheduled for submittal in October 1996 (40 CFR 191) and the No-Migration Variance Petition (40 CFR 268.6) scheduled for submittal in June 1996. Section 5.4, Long-Term Waste Isolation Assessment summarizes the current status of the assessment.

NONE

1995-11-01

66

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2013 CFR

14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Flight safety system analysis...309 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...LICENSING LAUNCH SAFETY Flight Safety System §...

2013-01-01

67

Relationships between psychological safety climate facets and safety behavior in the rail industry: a dominance analysis.  

PubMed

The goals of this study were twofold: (1) to confirm a relationship between employee perceptions of psychological safety climate and safety behavior for a sample of workers in the rail industry and (2) to explore the relative strengths of relationships between specific facets of safety climate and safety behavior. Non-management rail maintenance workers employed by a large North American railroad completed a survey (n=421) regarding workplace safety perceptions and behaviors. Three facets of safety climate (management safety, coworker safety, and work-safety tension) were assessed as relating to individual workers' reported safety behavior. All three facets were significantly associated with safety behavior. Dominance analysis was used to assess the relative importance of each facet as related to the outcome, and work-safety tension evidenced the strongest relationship with safety behavior. PMID:20538102

Morrow, Stephanie L; McGonagle, Alyssa K; Dove-Steinkamp, Megan L; Walker, Curtis T; Marmet, Matthew; Barnes-Farrell, Janet L

2009-09-16

68

SYNTHESIS OF SAFETY ANALYSIS AND FIRE HAZARD ANALYSIS METHODOLOGIES  

SciTech Connect

Successful implementation of both the nuclear safety program and fire protection program is best accomplished using a coordinated process that relies on sound technical approaches. When systematically prepared, the documented safety analysis (DSA) and fire hazard analysis (FHA) can present a consistent technical basis that streamlines implementation. If not coordinated, the DSA and FHA can present inconsistent conclusions, which can create unnecessary confusion and can promulgate a negative safety perception. This paper will compare the scope, purpose, and analysis techniques for DSAs and FHAs. It will also consolidate several lessons-learned papers on this topic, which were prepared in the 1990s.

Coutts, D

2007-04-17

69

DESIGN PACKAGE 1E SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate hazards related to the Yucca Mountain Project Exploratory Studies Facility (ESF) Design Package 1E, Surface Facilities, (for a list of design items included in the package 1E system safety analysis see section 3). This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the Design Package 1E structures/systems/components(S/S/Cs) in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the structure/system/component design, (2) add safety devices and capabilities to the designs that reduce risk, (3) provide devices that detect and warn personnel of hazardous conditions, and (4) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions.

M. Salem

1995-06-23

70

Rapid anharmonic vibrational corrections derived from partial Hessian analysis  

NASA Astrophysics Data System (ADS)

Vibrational analysis within a partial Hessian framework can successfully describe the vibrational properties of a variety of systems where the vibrational modes of interest are localized within a speci?c region of the system. We have developed a new approach to calculating anharmonic frequencies based on vibrational frequencies and normal modes obtained from a partial Hessian analysis using second-order vibrational perturbation theory and the transition optimized shifted Hermite method. This allows anharmonic frequencies for vibrational modes that are spatially localized to be determined at a significantly reduced computational cost. Several molecular systems are examined in order to demonstrate the effectiveness of this method including organic molecules adsorbed on the Si(100)-2×1 surface, model peptides in solution, and the C-H stretching region of polycyclic aromatic hydrocarbons. Overall, for a range of systems, anharmonic frequencies calculated using the partial Hessian approach are found to be in close agreement with the results obtained using full anharmonic calculations while providing a significant reduction in computational cost.

Hanson-Heine, Magnus W. D.; George, Michael W.; Besley, Nicholas A.

2012-06-01

71

ARIES-AT safety design and analysis  

Microsoft Academic Search

ARIES-AT is a 1000MWe conceptual fusion power plant design with a very low projected cost of electricity. The design contains many innovative features to improve both the physics and engineering performance of the system. From the safety and environmental perspective, there is greater depth to the overall analysis than in past ARIES studies. For ARIES-AT, the overall spectrum of off-normal

D. A. Petti; B. J. Merrill; R. L. Moore; G. R. Longhurst; L. El-Guebaly; E. Mogahed; D. Henderson; P. Wilson; A. Abdou

2006-01-01

72

Computer graphics in reactor safety analysis  

SciTech Connect

This paper describes a family of three computer graphics codes designed to assist the analyst in three areas: the modelling of complex three-dimensional finite element models of reactor structures; the interpretation of computational results; and the reporting of the results of numerical simulations. The purpose and key features of each code are presented. The graphics output used in actual safety analysis are used to illustrate the capabilities of each code. 5 refs., 10 figs.

Fiala, C.; Kulak, R.F.

1989-01-01

73

Preliminary Safety Analysis for the IRIS Reactor  

Microsoft Academic Search

A deterministic analysis of the IRIS safety features has been carried out by means of the best-estimate code RELAP (ver. RELAP5 mod3.2). First, the main system components were modeled and tested separately, namely: the Reactor Pressure Vessel (RPV), the modular helical-coil Steam Generators (SG) and the Passive (natural circulation) Emergency Heat Removal System (PEHRS). Then, a preliminary set of accident

M. E. Ricotti; A. Cammi; A. Cioncolini; C. Lombardi; A. Cipollaro; F. Orioto; L. E. Conway; A. C. Barroso

2002-01-01

74

Free vibration analysis of partially filled liquid storage tanks  

SciTech Connect

A study on the free vibration analysis of partially filled liquid storage tanks is presented. The tanks considered are the upright circular cylindrical tanks that are rigidly supported at the base. The top of the tanks are either free or constrained. Two types of constraints are considered, namely, hinged and roller support. The governing differential equations for the tank-liquid system are obtained by application of the Rayleigh-Ritz procedure in combination with Lagrange`s equation. The response functions examined include the frequency of the fundamental mode of vibration of the tank-liquid system and the associated modal pressure.

Tang, Yu; Chang, Y.W.

1993-05-01

75

FEM analysis of partial flash processing for a plate  

NASA Astrophysics Data System (ADS)

FEM analysis of Partial Flash Processing (PFP) was carried out by ANSYS to simulate the heat treatment of wear-resistant steel plate. PFP involves rapid induction heating and water cooling to get different properties of a plate in thickness direction. The steel plate which moves at a given velocity is heated by a stationary inductor and then cooled by spraying water. The temperature filed and the difference of microstructure and properties of the plate in PFP were studied. The electromagnetic and thermal coupled problem will be solved by sequentially coupled physics analysis. The nonlinearities of both the electromagnetic and thermal material properties are also taken into account. Cooling condition will be loaded as a function of water spray position on the surface of steel plate. The FEM analysis results are compared with the measure data, and they are in good accordance. The microstructure and the depth of hardening layer prove the FEM analysis results are credible. The relationship between the temperature distribution and the processing parameters, such as induction frequency, current density etc., were built up. The numerical analysis provides a basis for further theoretical analysis and parameter optimization of PFP.

Chen, Qing-an; Liu, Xiang-hua

2013-05-01

76

FFTF Final Safety Analysis Report Amendment 82  

SciTech Connect

This is the Final Safety Analysis Report (FSAR) Amendment 82 for incorporation into the Fast Flux Test Facility (FFTF) FSAR set assigned to you. This page change amendment incorporates changes previously approved by the U.S. Department of Energy, Richland Operations Office. This amendment provides updates to the FSAR to facilitate FFTF shutdown and deactivation. Among the changes are the following: Chapter 11 is updated to describe upgrades to the Solid Waste Cask. Additional fuel handling accidents are added to Chapter 15. Appendix G is revised to clearly identify systems and their safety functions. Appendix H is revised to remove the discussion of material that has been removed from the Interim Storage Area. Appendix I is revised to provide a general description of liquid metal removal from FFTF. Other changes include minor technical updates from the FSAR annual review and editorial and procedure references.

DAUTEL, W.A.

2003-03-01

77

Hydra - an Implicit Partial Differential Equation Relaxation Stability Analysis Package  

NASA Astrophysics Data System (ADS)

A brief description is given of HYDRA, a numerical analysis code designed to provide a rather complete analysis of many difficult problems often encountered in astrophysical contexts. The primary use for this system is the solution of implicit partial differential equations. Given the difference equations and a trial solution, options include (1) forward time integration, (2) relaxation to steady state, (3) stability of steady state and time evolution, (4) numerical stability check, and (5) driven oscillations. Extensive input/output and debug facilities are provided, including dump/restart, variable plots, and initialization from a given state with an eigenvector perturbation. Generalization to solve global problems such as computations of periodic solutions and their stability is straightforward.

Stellingwerf, R. F.

1983-08-01

78

Natural circulation reactor design safety analysis  

NASA Astrophysics Data System (ADS)

This thesis study covers both global performance and local phenomena analyses focusing on natural circulation reactor design safety. Four important topics are included: the global SBWR design safety assessment, important local phenomena investigation, steady and transient natural circulation process study, and two-phase instability analysis. The conceptual design of the SBWR-200 is introduced in this thesis and the global performance of a natural circulation reactor is then assessed using PUMA integral test data and RELAP5 simulations. A safety assessment methodology is developed to evaluate the PUMA integral test data extrapolation and code scalability. The RELAP5 code simulation capability in low-pressure low-flow conditions is also validated. The study shows that the code is capable of predicting the global accident scenario in natural circulation reactors with reasonable accuracy, while failing to reproduce some safety related local phenomena. The natural circulation process is investigated in detail using PUMA separate effect natural circulation tests. The natural circulation flow rate and heat transfer rate have been modeled analytically and numerically. The work indicates that two-phase natural circulation has enough capability to remove decay power. However, the flow instability observed in two-phase natural circulation cases seriously challenges the feasibility of natural circulation reactor design. The instability is classified as a type of density wave instability induced by flashing. A detailed stability study is performed focusing on flashing induced instability under natural circulation condition. Various flashing phenomena have been studied and a mechanistic flashing model has been proposed and improved using a relaxation method. The developed relaxation flashing model can be applied to general two-phase non-equilibrium phenomena.

Zheng, Dong

2001-07-01

79

Safety analysis report for packaging upgrade plan  

SciTech Connect

This Safety Analysis Report for Packaging (SARP) Upgrade Plan reflects a revised SARP upgrade schedule based on the most current program needs. A Project Hanford Management Contract (PHMC) Performance Expectation exists to update, revise, and/or cancel seven onsite SARPS during FY 1999. It is the U.S. Department of Energy's desire that 100% of the SARPs (which existed at the beginning of the PHMC Contract) be upgraded, revised, and/or canceled by the end of the five year contract. This plan is a ''living'' document and is used as a management tool.

KELLY, D.L.

1998-11-18

80

Poles of the Zagreb analysis partial-wave T matrices  

NASA Astrophysics Data System (ADS)

The Zagreb analysis partial-wave T matrices included in the Review of Particle Physics [by the Particle Data Group (PDG)] contain Breit-Wigner parameters only. As the advantages of pole over Breit-Wigner parameters in quantifying scattering matrix resonant states are becoming indisputable, we supplement the original solution with the pole parameters. Because of an already reported numeric error in the S11 analytic continuation [Batini? , Phys. Rev. CPRVCAN0556-281310.1103/PhysRevC.57.1004 57, 1004(E) (1997); arXiv:nucl-th/9703023], we declare the old BATINIC 95 solution, presently included by the PDG, invalid. Instead, we offer two new solutions: (A) corrected BATINIC 95 and (B) a new solution with an improved S11 ?N elastic input. We endorse solution (B).

Batini?, M.; Ceci, S.; Švarc, A.; Zauner, B.

2010-09-01

81

Partial wave analysis of ?(2S)?pp¯?  

NASA Astrophysics Data System (ADS)

Using a sample of 1.06×108 ?(2S) events collected with the BESIII detector at BEPCII, the decay ?(2S)?pp¯? is studied. A partial wave analysis determines that the intermediate state N(1535) with a mass of 1524±5-4+10MeV/c2 and a width of 130-24-10+27+57MeV/c2 is dominant in the decay; the product branching fraction is determined to be B(?(2S)?N(1535)p¯)×B(N(1535)?p?)+c.c.=(5.2±0.3-1.2+3.2)×10-5. Furthermore, the branching fraction of ?(2S)?pp¯? is measured to be (6.4±0.2±0.6)×10-5. Here, the first error is statistical and the second is systematic.

Ablikim, M.; Achasov, M. N.; Albayrak, O.; Ambrose, D. J.; An, F. F.; An, Q.; Bai, J. Z.; Baldini Ferroli, R.; Ban, Y.; Becker, J.; Bennett, J. V.; Bertani, M.; Bian, J. M.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Bytev, V.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X.; Chen, Y. B.; Cheng, H. P.; Chu, Y. P.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J. P.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; Ding, W. M.; Ding, Y.; Dong, L. Y.; Dong, M. Y.; Du, S. X.; Fang, J.; Fang, S. S.; Fava, L.; Feng, C. Q.; Friedel, P.; Fu, C. D.; Fu, J. L.; Fuks, O.; Gao, Y.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, T.; Guo, Y. P.; Han, Y. L.; Harris, F. A.; He, K. L.; He, M.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Huang, G. M.; Huang, G. S.; Huang, J. S.; Huang, L.; Huang, X. T.; Huang, Y.; Huang, Y. P.; Hussain, T.; Ji, C. S.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. L.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jing, F. F.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Kopf, B.; Kornicer, M.; Kühn, W.; Lai, W.; Lange, J. S.; Larin, P.; Leyhe, M.; Li, C. H.; Li, Cheng; Li, Cui; Li, D. M.; Li, F.; Li, G.; Li, H. B.; Li, J. C.; Li, K.; Li, Lei; Li, Q. J.; Li, S. L.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, X. R.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, X. T.; Lin, D.; Liu, B. J.; Liu, C. L.; Liu, C. X.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H.; Liu, H. B.; Liu, H. H.; Liu, H. M.; Liu, H. W.; Liu, J. P.; Liu, K.; Liu, K. Y.; Liu, Kai; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lu, G. R.; Lu, H. J.; Lu, J. G.; Lu, Q. W.; Lu, X. R.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lv, M.; Ma, C. L.; Ma, F. C.; Ma, H. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. Y.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Moeini, H.; Morales Morales, C.; Moriya, K.; Muchnoi, N. Yu.; Muramatsu, H.; Nefedov, Y.; Nicholson, C.; Nikolaev, I. B.; Ning, Z.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Park, J. W.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Ping, J. L.; Ping, R. G.; Poling, R.; Prencipe, E.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Rong, G.; Ruan, X. D.; Sarantsev, A.; Schaefer, B. D.; Shao, M.; Shen, C. P.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, W. M.; Song, X. Y.; Spataro, S.; Spruck, B.; Sun, D. H.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tian, H. L.; Toth, D.; Ullrich, M.; Uman, I.; Varner, G. S.; Wang, B. Q.; Wang, D.; Wang, D. Y.; Wang, J. X.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q. J.; Wang, S. G.; Wang, X. F.; Wang, X. L.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wei, D. H.; Wei, J. B.; Weidenkaff, P.; Wen, Q. G.; Wen, S. P.; Werner, M.; Wiedner, U.; Wu, L. H.; Wu, N.; Wu, S. X.; Wu, W.; Wu, Z.; Xia, L. G.; Xia, Y. X.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, G. M.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Xu, Z. R.; Xue, F.; Xue, Z.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. X.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yu, B. X.; Yu, C. X.; Yu, H. W.; Yu, J. S.; Yu, S. P.; Yuan, C. Z.; Yuan, Y.; Zafar, A. A.; Zallo, A.; Zang, S. L.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, LiLi; Zhang, R.; Zhang, S. H.; Zhang, X. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhang, Zhenghao; Zhao, G.; Zhao, H. S.; Zhao, J. W.; Zhao, K. X.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, X. H.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhu, C.; Zhu, K.; Zhu, K. J.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. M.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.

2013-08-01

82

Analysis of high frequency partials in Bayesian harmonic model  

Microsoft Academic Search

Bayesian harmonic modeling and parameters estimation is a new approach in audio signal synthesizing. However current Bayesian harmonic modeling canpsilat effectively extract high frequency partials. In this paper we propose an improved model with parameters of high frequency partials for audio signal with harmonic modeling. We estimate partials in a Bayesian framework with the prior knowledge and likelihood function of

Jinghua Yan; Hui Wang; Chuanzhen Li; Qin Zhang

2008-01-01

83

The Use of Partial Residual Plots in Regression Analysis  

Microsoft Academic Search

This paper defines partial residuals in multiple linear regression. The ith partial residual vector can be thought of as the dependent variable vector corrected for all independent variables except the ith variable. A plot of the ith partial residuals vs values of the ith variable is proposed as a replacement for the usual plot displaying ordinary residuals vs the ith

Wayne A. Larsen; Susan J. McCleary

1972-01-01

84

242-A evaporator safety analysis report  

SciTech Connect

This report provides a revised safety analysis for the upgraded 242-A Evaporator (the Evaporator). This safety analysis report (SAR) supports the operation of the Evaporator following life extension upgrades and other facility and operations upgrades (e.g., Project B-534) that were undertaken to enhance the capabilities of the Evaporator. The Evaporator has been classified as a moderate-hazard facility (Johnson 1990). The information contained in this SAR is based on information provided by 242-A Evaporator Operations, Westinghouse Hanford Company, site maintenance and operations contractor from June 1987 to October 1996, and the existing operating contractor, Waste Management Hanford (WMH) policies. Where appropriate, a discussion address the US Department of Energy (DOE) Orders applicable to a topic is provided. Operation of the facility will be compared to the operating contractor procedures using appropriate audits and appraisals. The following subsections provide introductory and background information, including a general description of the Evaporator facility and process, a description of the scope of this SAR revision,a nd a description of the basic changes made to the original SAR.

CAMPBELL, T.A.

1999-05-17

85

Use risk analysis as a safety tool  

SciTech Connect

Safety managers of hydrocarbon processing industry (HPI) facilities must use a yardstick to estimate potential losses from accidents and convert accident risk into a quantified value. Quantitative risk assessment (QRA) is a yardstick that places numeric values on losses such as fatalities to employees and the public, interruption of business during reconstruction, damage to buildings, equipment, etc. and departure from business areas. No realistic method can remove all risk from an operating facility. However, stricter environmental and worker protection regulations require HPI managers to evaluate their operations, find vulnerable or hot-spot areas and take action. Logical analysis methods such as fault tree, event tree or cause-consequence diagrams can use safety audit information to identify and rank high-risk areas. After finding hazardous situations, manpower and capital can be allocated to eliminate potential accidents and reduce risk. The paper discusses QRA as a management tool, underlying principles, yardsticks to quantify risk, event analysis, limitations of QRA, and setting-up of a QRA project.

Mani, G. (Kuwait National Petroleum Co. (Kuwait). Shuaiba Refinery)

1994-09-01

86

Safety analysis of a frontal collision warning system  

Microsoft Academic Search

The paper deals with the development and the safety analysis of a multi-sensors frontal collision warning system (FCWS) for ground vehicles. This paper describes the system and the approach used to analyze it by taking into account the safety requirements. The system development is based on the fault tolerant concept using diverse sensors in order to implement safety critical warning

Etienne Lemaire; El-Miloudi El Koursi; Pascal Deloof; Jean-Pierre Ghys

2002-01-01

87

SNF fuel retrieval sub project safety analysis document  

Microsoft Academic Search

This safety analysis is for the SNF Fuel Retrieval (FRS) Sub Project. The FRS equipment will be added to K West and K East Basins to facilitate retrieval, cleaning and repackaging the spent nuclear fuel into Multi-Canister Overpack baskets. The document includes a hazard evaluation, identifies bounding accidents, documents analyses of the accidents and establishes safety class or safety significant

1999-01-01

88

Overview of Energy Systems' safety analysis report programs  

SciTech Connect

The primary purpose of an Safety Analysis Report (SAR) is to provide a basis for judging the adequacy of a facility's safety. The SAR documents the safety analyses that systematically identify the hazards posed by the facility, analyze the consequences and risk of potential accidents, and describe hazard control measures that protect the health and safety of the public and employees. In addition, some SARs document, as Technical Safety Requirements (TSRs, which include Technical Specifications and Operational Safety Requirements), technical and administrative requirements that ensure the facility is operated within prescribed safety limits. SARs also provide conveniently summarized information that may be used to support procedure development, training, inspections, and other activities necessary to facility operation. This Overview of Energy Systems Safety Analysis Report Programs'' Provides an introduction to the programs and processes used in the development and maintenance of the SARs. It also summarizes some of the uses of the SARs within Energy Systems and DOE.

Not Available

1992-03-01

89

On validation of the safety analysis of modern railway systems  

Microsoft Academic Search

Safety analysis is a key activity for the development of railway transportation systems. The analysis is used not only to determine whether new systems do not expose the general public to unduly high levels of risks, but also to inform the development process itself through identification and allocation of appropriate requirements. Whilst inadequate and inaccurate safety analysis may have potentially

Oleg Lisagor; Linling Sun; Tim Kelly; Chao Liu; Ru Niu

2011-01-01

90

Empirical Analysis of Safety-Critical Anomalies During Operations  

Microsoft Academic Search

Analysis of anomalies that occur during operations is an important means of improving the quality of current and future software. Although the benefits of anomaly analysis of operational software are widely recognized, there has been relatively little research on anomaly analysis of safety-critical systems. In particular, patterns of software anomaly data for operational, safety-critical systems are not well understood. This

Robyn R. Lutz; Ines Carmen Mikulski

2004-01-01

91

Information Services at the Nuclear Safety Analysis Center.  

ERIC Educational Resources Information Center

This paper describes the operations of the Nuclear Safety Analysis Center. Established soon after an accident at the Three Mile Island nuclear power plant near Harrisburg, Pennsylvania, its efforts were initially directed towards a detailed analysis of the accident. Continuing functions include: (1) the analysis of generic nuclear safety issues,…

Simard, Ronald

92

Information Services at the Nuclear Safety Analysis Center.  

ERIC Educational Resources Information Center

|This paper describes the operations of the Nuclear Safety Analysis Center. Established soon after an accident at the Three Mile Island nuclear power plant near Harrisburg, Pennsylvania, its efforts were initially directed towards a detailed analysis of the accident. Continuing functions include: (1) the analysis of generic nuclear safety issues,…

Simard, Ronald

93

Safety Analysis LOX-30 Liquid Oxygen Generator.  

National Technical Information Service (NTIS)

Safety of the LOX-30 Liquid Oxygen Generator was evaluated in accordance with MIL-STD-882. Thirteen safety/control devices and fifteen operational areas were extensively analyzed. Twenty-seven hazard classifications were assigned. Location of the storage ...

R. Ferret

1978-01-01

94

Analysis of partial iris recognition using a 1D approach  

Microsoft Academic Search

Iris recognition has been shown to be very accurate for human identification. We investigate the performance of the use of a partial iris for recognition. A partial iris identification system based on a one-dimensional approach to iris identification is developed. Experiment results show that a more distinguishable and individually unique signal is found in the inner rings of the iris.

Yingzi Du; Bradford Bonney; Robert Ives; Delores Etter; Robert Schultz

2005-01-01

95

Safety Evaluation Report of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis  

SciTech Connect

This Safety Evaluation Report (SER) documents the Department of Energy’s (DOE's) review of Revision 9 of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis, DOE/WIPP-95-2065 (WIPP CH DSA), and provides the DOE Approval Authority with the basis for approving the document. It concludes that the safety basis documented in the WIPP CH DSA is comprehensive, correct, and commensurate with hazards associated with CH waste disposal operations. The WIPP CH DSA and associated technical safety requirements (TSRs) were developed in accordance with 10 CFR 830, Nuclear Safety Management, and DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Safety Analysis Reports.

Washington TRU Solutions LLC

2005-09-01

96

Identifying and Implementing Corridor Safety Improvements: A Highway Safety Improvement Process and Safety Analysis Tools for Arizona.  

National Technical Information Service (NTIS)

Arizona Department of Transportation (ADOT) recognizes that evaluation of highway safety from a corridor perspective provides different benefits than the spot analysis used up until now. The project programming procedure at ADOT accepts a quantitative ran...

J. P. Breyer S. C. Joshua

1999-01-01

97

Robotic Partial Nephrectomy for Renal Tumors Larger than 4 cm: A Systematic Review and Meta-analysis  

PubMed Central

Background With the establishment of minimally invasive surgery in society, the robot has been increasingly widely used in the urologic field, including in partial nephrectomy. This study aimed to comprehensively summarize the currently available evidence on the feasibility and safety of robotic partial nephrectomy for renal tumors of >4 cm. Method and Findings An electronic database search of PubMed, Scopus, Web of Science, and the Cochrane Library was performed. This systematic review and meta-analysis was based on all relevant studies that assessed robotic partial nephrectomy for renal tumors of >4 cm. Five studies were included. The meta-analysis involved 3 studies from 11 institutions including 154 patients, while the narrative review involved the remaining 2 studies from 5 institutions including 64 patients. In the meta-analysis, the mean ischemic time, operation time, and console time was 28, 319, and 189 minutes, respectively. The estimated blood loss and length of stay was 317 ml and 3.8 days, respectively. The rates of conversion, positive margins, intraoperative complications, postoperative complications, hilar clamping, and collecting system repair were 7.0%, 3.5%, 7.0%, 9.8%, 93.9%, and 47.5%, respectively. The narrative review showed results similar to those of the meta-analysis. Conclusions Robotic partial nephrectomy is feasible and safe for renal tumors of >4 cm with an acceptable warm ischemic time, positive margin rate, conversion rate, complication rate, operation time, estimated blood loss, and length of stay.

Fan, Xinxiang; Xu, Kewei; Han, Jinli; Huang, Hai; Liu, Hao; Dong, Wen; Huang, Jian; Lin, Tianxin

2013-01-01

98

Analysis of Safety Requirements for Large Offshore Units Evacuation Systems. LSA safety function  

NASA Astrophysics Data System (ADS)

The paper presents the problems related to the effectiveness of evacuation systems for large offshore installations. The analysis of safety requirements related to the complex evacuation, escape and rescue (EER) system elements has been carried out on the basis of the reports from the accidents of offshore drilling and production platforms. The safety function developed for life saving appliances (LSA) - the 6, 10 and 20 persons liferafts is presented as an example of a method for life saving appliances safety assessment.

Abramowicz-Gerigk, Teresa; Burciu, Zbigniew

2012-12-01

99

Safety Evaluation Report of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis  

Microsoft Academic Search

This Safety Evaluation Report (SER) documents the Department of Energyâs (DOE's) review of Revision 9 of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis, DOE\\/WIPP-95-2065 (WIPP CH DSA), and provides the DOE Approval Authority with the basis for approving the document. It concludes that the safety basis documented in the WIPP CH DSA is comprehensive, correct,

2005-01-01

100

Aggregate nonparametric safety analysis of traffic zones.  

PubMed

Exploring the significant variables related to specific types of crashes is vitally important in the planning stage of a transportation network. This paper aims to identify and examine important variables associated with total crashes and severe crashes per traffic analysis zone (TAZ) in four counties of the state of Florida by applying nonparametric statistical techniques such as data mining and random forest. The intention of investigating these factors in such aggregate level analysis is to incorporate proactive safety measures in transportation planning. Total and severe crashes per TAZ were modeled to provide predictive decision trees. The variables which carried higher weight of importance for total crashes per TAZ were - total number of intersections per TAZ, airport trip productions, light truck productions, and total roadway segment length with 35 mph posted speed limit. The other significant variables identified for total crashes were total roadway length with 15 mph posted speed limit, total roadway length with 65 mph posted speed limit, and non-home based work productions. For severe crashes, total number of intersections per TAZ, light truck productions, total roadway length with 35 mph posted speed limit, and total roadway length with 65 mph posted speed limit were among the significant variables. These variables were further verified and supported by the random forest results. PMID:22269515

Siddiqui, Chowdhury; Abdel-Aty, Mohamed; Huang, Helai

2011-09-17

101

Genomic analysis of partial 21q monosomies with variable phenotypes  

Microsoft Academic Search

Partial monosomy 21 was recently segregated into three regions associated with variable clinical severity. We describe 10 new patients, all examined by single nucleotide polymorphism (SNP) genotyping and G-banded karyotyping. Cohort A consisted of three patients seen in our medical genetics clinics with partial chromosome 21 monosomies. In two of these patients having terminal deletions (21q22.2-ter and 21q22.3-ter), the breakpoints

Elisha D O Roberson; Elizabeth Squibb Wohler; Julie E Hoover-Fong; Emily Lisi; Eric L Stevens; George H Thomas; Jay Leonard; Ada Hamosh; Jonathan Pevsner

2011-01-01

102

Safety analysis of CSTR towards changes in operating conditions  

Microsoft Academic Search

Exothermic reactions are the most interesting systems for safety analysis because of their potential safety problems and the possibility of exotic behavior such as multiple steady states. A sensitivity analysis of an exothermic reaction involving the hydrolysis of propylene oxide to propylene glycol in a CSTR with jacket cooling is presented here. The objective of this article is to determine

A. Molnár; J. Markoš; L’. Jelemenský

2003-01-01

103

ADVANCED SAFETY ENGINEERING USING COMPOSITIONAL ANALYSIS AND OPTIMISATION TECHNIQUES  

Microsoft Academic Search

Increasing complexity in computer technology questions the applicability of classical safety analysis techniques on new designs. As new technologies introduce complex failure modes, the classical manual analysis of critical systems becomes increasingly more difficult and error prone. To address these difficulties, we have developed two computerised tools that simplify aspects of the safety engineering process. The first tool largely automates

Yiannis Papadopoulos; Christian Grante; Wenhua Zeng

104

RSM Development for Nuclear Safety Analysis. A Test Problem.  

National Technical Information Service (NTIS)

Safety analysis of nuclear plants demands the running of complex simulation computer programs to provide probability distribution functions of particular outcomes. Response surface methodology (RSM) is a technique for simplifying the analysis by giving th...

A. Amendola B. Lisanti F. Argentesi M. Astolfi S. Canali

1981-01-01

105

TA-55 Final Safety Analysis Report Comparison Document and DOE Safety Evaluation Report Requirements  

SciTech Connect

This document provides an overview of changes to the currently approved TA-55 Final Safety Analysis Report (FSAR) that are included in the upgraded FSAR. The DOE Safety Evaluation Report (SER) requirements that are incorporated into the upgraded FSAR are briefly discussed to provide the starting point in the FSAR with respect to the SER requirements.

Alan Bond

2001-04-01

106

14 CFR Appendix A to Part 417 - Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety...  

Code of Federal Regulations, 2010 CFR

...417.107(b). When employing hazard isolation, the analysis must establish flight...flight safety analysis employs hazard isolation to establish flight safety limits as...safety analysis does not employ hazard isolation to establish the flight safety...

2010-01-01

107

14 CFR Appendix A to Part 417 - Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown with a Flight Safety...  

Code of Federal Regulations, 2010 CFR

...417.107(b). When employing hazard isolation, the analysis must establish flight...flight safety analysis employs hazard isolation to establish flight safety limits as...safety analysis does not employ hazard isolation to establish the flight safety...

2009-01-01

108

Preliminary Safety Analysis Report for the Tokamak Physics Experiment  

SciTech Connect

This Preliminary Safety Analysis Report (PSAR), includes an indication of the magnitude of facility hazards, complexity of facility operations, and the stage of the facility life-cycle. It presents the results of safety analyses, safety assurance programs, identified vulnerabilities, compensatory measures, and, in general, the rationale describing why the Tokamak Physics Experiment (TPX) can be safely operated. It discusses application of the graded approach to the TPX safety analysis, including the basis for using Department of Energy (DOE) Order 5480.23 and DOE-STD-3009-94 in the development of the PSAR.

Motloch, C.G.; Bonney, R.F. [Lockheed Idaho Technologies Co., Idaho Falls, ID (United States); Levine, J.D. [Princeton Univ., NJ (United States). Plasma Physics Lab.; McKenzie-Carter, M.A. [Science Applications International Corp., San Diego, CA (United States); Masson, L.S. [SCIENTECH, Inc., Idaho Falls, ID (United States); Commander, J.C.

1995-04-01

109

Analysis of US child care safety regulations.  

PubMed Central

BACKGROUND: With 1.9 million US children cared for in organized group child care, the safety of these children is a public health concern. In the absence of federal policy, each state has developed its own day care safety regulations. METHODS: After creating a set of 36 criteria from three sets of national guidelines, we assessed the safety regulations of 45 states. With a mailed survey of state day care regulatory personnel, we examined the processes of formulating and implementing safety policy in 47 states. RESULTS: For 24 of the 36 items, more than half the states' regulations were below the criteria or failed to mention the topic. Most notable is the inattention to playground safety, choking hazards, and firearms. CONCLUSION: The uneven quality of regulations may be a reflection of a regulatory process that is fragmented, with many different groups sharing authority and with limited involvement of injury prevention specialists.

Runyan, C W; Gray, D E; Kotch, J B; Kreuter, M W

1991-01-01

110

A safety analysis of warhead balancing  

SciTech Connect

Reentry vehicles (RVs) carrying warheads from ballistic missiles must be carefully balanced with the warhead in situ to prevent wobble as the RVs enter the earth`s atmosphere to prevent inaccuracy or loss of the warhead. This balancing is performed on a dynamic balancing machine that rotates the RV at significant angular velocities. Seizure of the spindle shaft of the machine could result in rapid deceleration of the rotating assembly, which could over-stress and shear bolts or other structures that attach the RV to the balancing machine. This could result in undesired motions of the RV and impact of the RV on equipment or structures in the work area. This potential safety problem has long been recognized in a general way, but no systematic investigation of the possible accident sequences had been performed. The purpose of this paper is to describe an integrated set of systems analysis techniques that worked well in developing a set of accident sequences that describe the motions of the RV following a spindle-shaft seizure event.

Bott, T.F.

1998-12-01

111

Microspectral analysis with laser in microleakage evaluation between infrastructure and veneer materials in fixed partial dentures  

Microsoft Academic Search

The microleakage at the interface between the metal infrastructure and the veneering part of the fixed partial dentures are a common problem of aesthetic dentistry. It is possible to use the method of laser microspectral analysis for investigations of microleakage at the metal-veneering material interfaces in fixed partial prostheses. The laser microspectral analysis device LMA-10 (Carl Zeiss, Jena) was used

Meda L. Negrutiu; Cosmin Sinescu; Gheorghe Draganescu; Carmen Todea; Dorin Dodenciu; Roxana Rominu

2008-01-01

112

Safety analysis report 231-Z Building  

SciTech Connect

This report provides an intensive review of the nuclear safety of the operation of the 231-Z Building. For background information complete descriptions of the floor plan, building services, alarm systems, and glove box systems are included in this report. In addition, references are included to The Plutonium Laboratory Radiation Work Procedures, Safety Guides, 231-Z Operating Procedures Manual and Nuclear Materials accountability Procedures. Engineered and administrative features contribute to the overall safety of personnel, the building, and environs. The consequences of credible incidents were considered and are discussed.

Powers, C.S.

1989-03-01

113

PHYSICS AND SAFETY ANALYSIS FOR THE NIST RESEARCH REACTOR  

Microsoft Academic Search

Detailed reactor physics and safety analyses have been performed for the 20 MW DO moderated research reactor (NBSR) at the National Institute of Standards and Technology (NIST). The analyses provide an update to the Final Safety Analysis Report (FSAR) and employ state-of-the-art calculational methods. Three-dimensional MCNP Monte Carlo neutron and photon transport calculations were performed to determine the safety parameters

J. CHENG; L. HANSON; J. RORER; D. DIAMOND

2003-01-01

114

SNF fuel retrieval sub project safety analysis document  

SciTech Connect

This safety analysis is for the SNF Fuel Retrieval (FRS) Sub Project. The FRS equipment will be added to K West and K East Basins to facilitate retrieval, cleaning and repackaging the spent nuclear fuel into Multi-Canister Overpack baskets. The document includes a hazard evaluation, identifies bounding accidents, documents analyses of the accidents and establishes safety class or safety significant equipment to mitigate accidents as needed.

BERGMANN, D.W.

1999-02-24

115

Safety analysis report for the Waste Storage Facility. Revision 2  

SciTech Connect

This safety analysis report outlines the safety concerns associated with the Waste Storage Facility located in the Radioactive Waste Management Complex at the Idaho National Engineering Laboratory. The three main objectives of the report are: define and document a safety basis for the Waste Storage Facility activities; demonstrate how the activities will be carried out to adequately protect the workers, public, and environment; and provide a basis for review and acceptance of the identified risk that the managers, operators, and owners will assume.

Bengston, S.J.

1994-05-01

116

Thermo-hydro-mechanical analysis of partially saturated porous materials  

Microsoft Academic Search

Presents a fully coupled numerical model to simulate the slow transient phenomena involving heat and mass transfer in deforming partially saturated porous materials. Makes use of the modified effective stress concept together with the capillary pressure relationship. Examines phase changes (evaporation-condensation(, heat transfer through conduction and convection, as well as latent heat transfer. The governing equations in terms of gas

Dariusz Gawin; Bernhard A. Schrefler; M. Galindo

1996-01-01

117

Analysis of partial discharges measurements and generator technology evolution  

Microsoft Academic Search

The use of partial discharge measurements a means of monitoring generators achieves two goals: (1) detecting as soon as possible any mechanical flaw occurring in a generator and, after technological study and visual inspection, working out a suitably adapted maintenance; and (2) monitoring internal electrical aging of insulation systems so as to plan stator refurbishments. It is noted that, with

A. Audoli; J.-L. Drommi

1991-01-01

118

Fracture surface analysis of clinically failed fixed partial dentures.  

PubMed

Ceramic systems have limited long-term fracture resistance, especially when they are used in posterior areas or for fixed partial dentures. The objective of this study was to determine the site of crack initiation and the causes of fracture of clinically failed ceramic fixed partial dentures. Six Empress 2 lithia-disilicate (Li(2)O x 2SiO(2))-based veneered bridges and 7 experimental lithia-disilicate-based non-veneered ceramic bridges were retrieved and analyzed. Fractography and fracture mechanics methods were used to estimate the stresses at failure in 6 bridges (50%) whose fracture initiated from the occlusal surface of the connectors. Fracture of 1 non-veneered bridge (8%) initiated within the gingival surface of the connector. Three veneered bridges fractured within the veneer layers. Failure stresses of the all-core fixed partial dentures ranged from 107 to 161 MPa. Failure stresses of the veneered fixed partial dentures ranged from 19 to 68 MPa. We conclude that fracture initiation sites are controlled primarily by contact damage. PMID:16498078

Taskonak, B; Mecholsky, J J; Anusavice, K J

2006-03-01

119

Fracture Surface Analysis of Clinically Failed Fixed Partial Dentures  

PubMed Central

Ceramic systems have limited long-term fracture resistance, especially when they are used in posterior areas or for fixed partial dentures. The objective of this study was to determine the site of crack initiation and the causes of fracture of clinically failed ceramic fixed partial dentures. Six Empress 2® lithia-disilicate (Li2O·2SiO2)-based veneered bridges and 7 experimental lithia-disilicate-based non-veneered ceramic bridges were retrieved and analyzed. Fractography and fracture mechanics methods were used to estimate the stresses at failure in 6 bridges (50%) whose fracture initiated from the occlusal surface of the connectors. Fracture of 1 non-veneered bridge (8%) initiated within the gingival surface of the connector. Three veneered bridges fractured within the veneer layers. Failure stresses of the all-core fixed partial dentures ranged from 107 to 161 MPa. Failure stresses of the veneered fixed partial dentures ranged from 19 to 68 MPa. We conclude that fracture initiation sites are controlled primarily by contact damage.

Taskonak, B.; Mecholsky, J.J.; Anusavice, K.J.

2008-01-01

120

Auger analysis of a calcium partially stabilized zirconia  

Microsoft Academic Search

Partially stabilized zirconia (PSZ) offers unique properties compared to other strong ceramics, especially in terms of fracture toughness. This increased toughness is due to the crack tip stressassisted martensitic transformation of tetragonal phase precipitates to the monoclinic phase [1]. The large volume expansion and resulting compressive stresses are believed to retard growing cracks in PSZ. A limitation in applying ceramics

Robert Sherman

1984-01-01

121

Safety analysis in design--evaluation of a case study.  

PubMed

Safety analysis was applied in the design of a section at a paper mill. The case study involved analysis of layout, transport system, machines, and a number of different activities. The purpose of the analysis was to find measures to decrease occupational accidents. Three years after the installation was finished the occurrence of accidents was investigated. There was a 56% decrease in the number of accidents; the number of working days lost due to accidents was diminished by 75% as compared to 4 years preceding. The results of the safety analysis were also evaluated with respect to the accidents which had occurred. The methods for safety analysis seem to have been efficient in identifying hazards. The general conclusion of the study is that safety analysis can be an effective tool to decrease occupational accident risks. PMID:3651203

Harms-Ringdahl, L

1987-08-01

122

Safety Analysis of Nuclear Concrete Containment Structures.  

National Technical Information Service (NTIS)

The objective of this work is to present a procedure for calculating the reliability of a concrete containment structure in terms of a safety index when the random variables entering into the design equations are defined by their probability distribution ...

P. Petrina R. Sexsmith R. N. White

1979-01-01

123

Safety Analysis and Review System (SARS).  

National Technical Information Service (NTIS)

The basic requirements and responsibilities outlined in DOE Order 5481.1A are described. The status of Office of Operational Safety evaluation of existing programs and the assistance being provided by Los Alamos, and anticipated evaluation activities are ...

J. M. Graf J. J. Lopez

1984-01-01

124

Analysis of a color space conversion engine implemented using dynamic partial reconfiguration  

NASA Astrophysics Data System (ADS)

Dynamic Partial Reconfiguration allows parts of a Field Programmable Gate Array to be reconfigured, while the rest of the system continues uninterrupted operation. A Color Space Conversion Engine is a digital image-processing pipeline, which requires frequent reconfiguration of some, but not all of its stages. Therefore, it is a digital signal processing system that presumably can take advantage of dynamic partial reconfiguration. This paper describes the necessary design changes, testing, and performance analysis of a color space conversion engine implemented onto a field programmable gate array using dynamic partial reconfiguration. The analysis provides insight into the operational scenarios in which dynamic partial reconfiguration is advantageous or not.

Toukatly, Ryan; Patru, Dorin; Saber, Eli; Peskin, Eric; Roylance, Gene; Larson, Brad

2013-02-01

125

Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel.  

PubMed

Introduction: Complex-partial seizures are frequently resistant to antiepileptic therapy. Two new medications with mechanisms of action novel within the antiepileptic class have recently received approval for the adjunctive treatment of partial (focal) seizures. Areas covered: A Medline search was conducted to identify preclinical and clinical studies of ezogabine and perampanel. This was supplemented with additional articles obtained from online sources and information provided by the FDA and the manufacturers. The focus of this review is on the safety profiles of ezogabine (retigabine), a novel antiepileptic that targets voltage-gated potassium channels, and perampanel, a noncompetitive ?-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate glutamate receptor antagonist. Expert opinion: Central nervous system effects are predominant within the adverse event profiles of both ezogabine and perampanel. In addition, ezogabine exerts its inhibitory effects on potassium channels in the urogenital tract potentially resulting in urinary retention and related outcomes. Recent reports of blue discoloration of the skin and in the retinas of long-term ezogabine users have surfaced. Both drugs have demonstrated the ability to induce neuropsychiatric symptoms. Though both are welcome additions to the antiepileptic drug class, additional monitoring, appropriate counseling, and careful selection of patients are warranted to minimize adverse events. PMID:23883095

Faulkner, Michele A; Burke, Rachel A

2013-07-25

126

Reduction of free fatty acids, safety, and pharmacokinetics of oral GS-9667, an A(1) adenosine receptor partial agonist.  

PubMed

GS-9667, a new selective, partial agonist of the A(1) adenosine receptor (AR), may represent an effective therapy for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA). The objectives of the studies were to evaluate the effects of single and multiple doses of GS-9667 on plasma FFA concentrations, its pharmacokinetics (PK) and safety/tolerability. Two studies were conducted. In the single ascending dose study, healthy, non-obese, and obese subjects received a single oral dose of GS-9667 (30-1,800?mg). In the multiple, ascending dose study, healthy, obese subjects received GS-9667 (600-2,400?mg QD, 1,200?mg BID, or 600?mg QID) for 14 days. Blood and urine samples were collected for lipid profiling and PK analyses. The ECG, vital signs, and subject tolerability were monitored. Doses of GS-9667 ?300?mg caused dose-dependent reductions in FFA levels that were reproducible over 14 days without evidence of desensitization or rebound. All doses were well tolerated. GS-9667 was rapidly absorbed and distributed; Steady-state concentrations were achieved within 3-5 days. The A(1) AR partial agonist GS-9667 reduced plasma FFA, exhibited linear kinetics, and was well-tolerated in healthy non-obese and obese subjects. PMID:23427000

Staehr, Peter M; Dhalla, Arvinder K; Zack, Julia; Wang, Xuegong; Ho, Yu L; Bingham, Justus; Belardinelli, Luiz

2013-02-20

127

Documented safety analysis for 209-E Facility critical mass laboratory  

SciTech Connect

This documented safety analysis (DSA) addresses the 209-E facility and associated requirements that apply to 200 Area Facility Deactivation (AFD) activities. The DSA was developed in accordance with DOE-STD-1120-98, ''Integration of Environment, Safety, and Health into Facility Disposition Activities''.

DODD, E.

2003-04-23

128

Quantitative analysis methodology in safety-critical microprocessor applications  

Microsoft Academic Search

In this paper, a quantitative methodology to be considered in safety-critical microprocessor applications is proposed. Some important aspects that must be considered in safety analysis work are discussed. We discuss how to evaluate the dangerous detectable and undetectable system failure rates in a single microprocessor board and the mean time to unsafe failure (MTTUF) of a critical system. The proposed

J. B Camargo; E Canzian; J. R Almeida; S. M Paz; B. A Basseto

2001-01-01

129

Licensee event report analysis for selected safety system valves  

Microsoft Academic Search

This analysis utilized the US Nuclear Regulatory Commission's Licensee Event Report (LER) file to estimate LER-based failure rates (LER rates) for selected safety system valves in operating nuclear power plants. In general, the selected safety systems included Pressurized Water Reactor (PWR) and Boiling Water Reactor (BWR) Emergency Core Cooling System (ECCS) valves, PWR Auxiliary Feed Water System (AFW) valves, and

W. H. Hubble; C. F. Miller

1979-01-01

130

Safety Analysis Report Update Program: Overview and Phase 1 implementation  

SciTech Connect

During FY 1989, the DOE-Oak Ridge Operations (ORO) office formed joint Operating Contractor/DOE-ORO organizations to address safety analysis related issues. The Safety Analysis Report Working Group (SARWG) took on the task of developing a strategy to address the issue of updating SARs to today's standards. The resulting SAR Update Program was approved by the Safety Analysis Report Management Group (SARMG) and on November 6, 1989, was accepted by the senior management of DOE-ORO, and its operating contractors, including Martin Marietta Energy Systems, Inc. This SAR Update Program consists of five phases: Phase 0 -- continued operation evaluations; Phase 1 -- hazard classification and qualitative analysis; Phase 1A -- updated operational safety requirements; Phase 2 -- quantitative accident analysis; and, Phase 3 -- complete DOE-approved SARs. 8 refs., 17 figs., 6 tabs.

Not Available

1991-08-01

131

Thermodynamic analysis of hydrogen production via partial oxidation of ethanol  

Microsoft Academic Search

Thermodynamic equilibrium of ethanol partial oxidation has been studied by Gibbs free energy minimization method for hydrogen production in the range of oxygen-to-ethanol molar ratio from 0 to 3, reaction temperature from 500 to 1400K, pressure from 1 to 20atm and nitrogen-to-ethanol molar ratio from 0 to 100. The optimal operation conditions were obtained, which are 1070–1200K, oxygen-to-ethanol molar ratio

Wenju Wang; Yaquan Wang

2008-01-01

132

Chemical and Physical Properties, Safety and Application of Partially Hydrolized Guar Gum as Dietary Fiber  

PubMed Central

The ideal water-soluble dietary fiber for the fiber-enrichment of foods must be very low in viscosity, tasteless, odorless, and should produce clear solutions in beverages. Partially hydrolyzed guar gum (PHGG) produced from guar gum by enzymatic process has the same chemical structure with intact guar gum but less than one-tenth the original molecular length of guar gum, which make available to be used as film former, foam stabilizer and swelling agent. The viscosity of PHGG is about 10 mPa·s in 5% aqueous solution, whereas 1% solution of guar gum shows range from 2,000 to 3,000 mPa·s. In addition, PHGG is greatly stable against low pH, heat, acid and digestive enzyme. For these reasons, PHGG seems to be one of the most beneficial dietary fiber materials. It also showed that interesting physiological functions still fully exert the nutritional function of a dietary fiber. PHGG has, therefore, been used primarily for a nutritional purpose and became fully integrated food material without altering the rheology, taste, texture and color of final products. PHGG named as Benefiber® in USA has self-affirmation on GRAS status of standard grade PHGG. PHGG named as Sunfiber® is now being used in various beverages, food products and medicinal foods as a safe, natural and functional dietary fiber in all over the world.

Yoon, Seon-Joo; Chu, Djong-Chi; Raj Juneja, Lekh

2008-01-01

133

F-Canyon Suspension and Deactivation Safety Analysis Reports  

SciTech Connect

This paper describes Savannah River Site's compliance with the Department of Energy (DOE) direction to suspend current operations, transition to accommodate revised facility missions, and initiate operations to deactivate F-Canyon using a suspension and deactivation safety basis. This paper integrates multiple Workshop theme topics - Lessons Learned from the Safety Analysis Process, Improvements in Documenting Hazard and Accident Analysis, and Closure Issues - Decontamination and Decommissioning. The paper describes the process used to develop safety documentation to support suspension and deactivation activities for F-Canyon. Embodied are descriptive efforts that include development of intermediate and final ''end states'' (e.g., transitional operations), preparation of safety bases documents to support transition, performance of suspension and deactivation activities (e.g. solvent washing, tank/sump flushing, and laboratory waste processing), and downgrade of Safety Class and Safety Significant equipment. The reduction and/or removal of hazards in the facility result in significant risk (frequency times consequence) reduction to the public, site workers, and the environment. Risk reduction then allows the downgrade of safety class and safety significant systems (e.g., ventilation system) and elimination of associated surveillances. The downgrade of safety systems results in significant cost savings.

LOW, JM

2004-04-30

134

Fast Flux Test Facility Final Safety Analysis Report. Amendment 80.  

National Technical Information Service (NTIS)

The report cotains the Final Safety Analysis Report (FSAR) Amendment 80 for incorporation into the Fast Flux Test Facility (FFTF) FSAR set. This page change amendment incorporates Engineering Change Notices previously approved by the U.S. Department of En...

W. A. Dautel

2000-01-01

135

Flightdeck Crew Alerting Issues: An Aviation Safety Reporting System Analysis.  

National Technical Information Service (NTIS)

This document describes an analysis of the Aviation Safety Reporting System (ASRS) database regarding flightdeck crew alerting deficiencies. The ASRS database contains thousands of reports concerning actual or potential deficiencies, which may compromise ...

A. Rehmann R. D. Mitman M. Neumeier M. C. Reynolds

1995-01-01

136

ESSAA: Embedded System Safety Analysis Assistant (Abstract Only).  

National Technical Information Service (NTIS)

The Embedded System Safety Analysis Assistant (ESSAA) is a knowledge-based tool that can assist in identifying disaster scenarios. Imbedded software issues hazardous control commands to the surrounding hardware. ESSAA is intended to work from outputs to i...

P. Wallace J. Holzer S. Guarro L. Hyatt

1987-01-01

137

Soft Mathematical Aggregation in Safety Assessment and Decision Analysis.  

National Technical Information Service (NTIS)

This paper improves on some of the limitations of conventional safety assessment and decision analysis methods. It develops a top-down mathematical method for expressing imprecise individual metrics as possibilistic or fuzzy numbers and shows how they may...

J. A. Cooper

1999-01-01

138

Analysis of Aircraft Overruns and Undershoots for Runway Safety Areas.  

National Technical Information Service (NTIS)

The objective of this project was to develop an aircraft overrun and undershoot risk assessment approach, supported by scientific evidence and statistical theory, which provides step-by-step procedures and instructions for analysis of runway safety areas ...

A. Appleyard H. Shirazi J. Hall M. Ayeres M. Eddowes

2008-01-01

139

Applied Behavior Analysis and Occupational Safety  

Microsoft Academic Search

Methods of generalization (Stokes & Baer, 1977) are applied to investigate contingencies that produce long-term response maintenance in large-scale behavioral interventions for industrial safety. It is proposed that characteristics representing four methods originally outlined by Stokes and Baer (1977) have an additive effect on the duration and amount of response maintenance obtained. To evaluate the validity of this conceptualization, a

Thomas E. Boyce; E. Scott Geller

2001-01-01

140

UNIPALS: SOFTWARE FOR PRINCIPAL COMPONENTS ANALYSIS AND PARTIAL LEAST SQUARES REGRESSION  

EPA Science Inventory

Software for the analysis of multivariate chemical data by principal components and partial least squares methods is included on disk. he methods extract latent variables from the chemical data with the UNIversal PArtial Least Squares or UNIPALS algorithm. he software is written ...

141

Partial order investigation of multiple indicator systems using variance-based sensitivity analysis  

Microsoft Academic Search

Partial order tools can be used in multiple criteria analysis to prioritize and rank a set of objects. In this setting the starting point is generally a matrix Mnxk of k observed indicators on n objects. Given that indicators are measured at least at the ordinal level, from matrix M its corresponding partially ordered set - poset - is set

Paola Annoni; Rainer Brüggemann; Andrea Saltelli

2011-01-01

142

Relevance of complex branch points for partial wave analysis  

SciTech Connect

A central issue in hadron spectroscopy is to deduce--and interpret--resonance parameters, namely, pole positions and residues, from experimental data, for those are the quantities to be compared to lattice QCD or model calculations. However, not every structure in the observables derives from a resonance pole: the origin might as well be branch points, either located on the real axis (when a new channel composed of stable particles opens) or in the complex plane (when at least one of the intermediate particles is unstable). In this paper we demonstrate first the existence of such branch points in the complex plane and then show on the example of the {pi}N P{sub 11} partial wave that it is not possible to distinguish the structures induced by the latter from a true pole signal based on elastic data alone.

Ceci, S.; Svarc, A. [Rudjer Boskovic Institute, Bijenicka 54, HR-10000 Zagreb (Croatia); Doering, M. [HISKP (Theorie), Universitaet Bonn, Nussallee 14-16, D-53115 Bonn (Germany); Hanhart, C.; Krewald, S. [Institut fuer Kernphysik and Juelich Center for Hadron Physics, Forschungszentrum Juelich, D-52425 Juelich (Germany); Institute for Advanced Simulation, Forschungszentrum Juelich, D-52425 Juelich (Germany); Meissner, U.-G. [HISKP (Theorie), Universitaet Bonn, Nussallee 14-16, D-53115 Bonn (Germany); Institut fuer Kernphysik and Juelich Center for Hadron Physics, Forschungszentrum Juelich, D-52425 Juelich (Germany); Institute for Advanced Simulation, Forschungszentrum Juelich, D-52425 Juelich (Germany)

2011-07-15

143

Multivariate analysis of remote LIBS spectra using partial least squares, principal component analysis, and related techniques  

SciTech Connect

Quantitative analysis with LIBS traditionally employs calibration curves that are complicated by the chemical matrix effects. These chemical matrix effects influence the LIBS plasma and the ratio of elemental composition to elemental emission line intensity. Consequently, LIBS calibration typically requires a priori knowledge of the unknown, in order for a series of calibration standards similar to the unknown to be employed. In this paper, three new Multivariate Analysis (MV A) techniques are employed to analyze the LIBS spectra of 18 disparate igneous and highly-metamorphosed rock samples. Partial Least Squares (PLS) analysis is used to generate a calibration model from which unknown samples can be analyzed. Principal Components Analysis (PCA) and Soft Independent Modeling of Class Analogy (SIMCA) are employed to generate a model and predict the rock type of the samples. These MV A techniques appear to exploit the matrix effects associated with the chemistries of these 18 samples.

Clegg, Samuel M [Los Alamos National Laboratory; Barefield, James E [Los Alamos National Laboratory; Wiens, Roger C [Los Alamos National Laboratory; Sklute, Elizabeth [MT HOLYOKE COLLEGE; Dyare, Melinda D [MT HOLYOKE COLLEGE

2008-01-01

144

Westinghouse Hanford Company safety analysis reports and technical safety requirements upgrade program  

SciTech Connect

During Fiscal Year 1992, the US Department of Energy, Richland Operations Office (RL) separately transmitted the following US Department of Energy (DOE) Orders to Westinghouse Hanford Company (WHC) for compliance: DOE 5480.21, ``Unreviewed Safety Questions,`` DOE 5480.22, ``Technical Safety Requirements,`` and DOE 5480.23, ``Nuclear Safety Analysis Reports.`` WHC has proceeded with its impact assessment and implementation process for the Orders. The Orders are closely-related and contain some requirements that are either identical, similar, or logically-related. Consequently, WHC has developed a strategy calling for an integrated implementation of the three Orders. The strategy is comprised of three primary objectives, namely: Obtain DOE approval of a single list of DOE-owned and WHC-managed Nuclear Facilities, Establish and/or upgrade the ``Safety Basis`` for each Nuclear Facility, and Establish a functional Unreviewed Safety Question (USQ) process to govern the management and preservation of the Safety Basis for each Nuclear Facility. WHC has developed policy-revision and facility-specific implementation plans to accomplish near-term tasks associated with the above strategic objectives. This plan, which as originally submitted in August 1993 and approved, provided an interpretation of the new DOE Nuclear Facility definition and an initial list of WHC-managed Nuclear Facilities. For each current existing Nuclear Facility, existing Safety Basis documents are identified and the plan/status is provided for the ISB. Plans for upgrading SARs and developing TSRs will be provided after issuance of the corresponding Rules.

Busche, D.M.

1995-09-01

145

10 CFR 63.112 - Requirements for preclosure safety analysis of the geologic repository operations area.  

Code of Federal Regulations, 2013 CFR

...Requirements for preclosure safety analysis of the...112 Energy NUCLEAR REGULATORY COMMISSION...Criteria Preclosure Safety Analysis § 63...timely emergency power to instruments...systems important to safety if there is a loss of primary electric power; (12)...

2013-01-01

146

Occupational Analysis: Safety and Health Coordinator  

NSDL National Science Digital Library

The Advanced Technology Environmental and Energy Center (ATEEC) has provided this document which includes an overview of general required competencies for safety and health coordinators in the workplace. General areas of competence such as monitoring health and physical hazards in the work environment, conducting audits and providing information are included, as well as specific tasks in each category. Users must download this resource for viewing, which requires a free log-in. There is no cost to download the item.

2011-03-09

147

Safety analysis approaches or mixed transuranic waste.  

SciTech Connect

Argonne National Laboratory (ANL) has completed a survey of assumptions and techniques used for safety analyses at seven sites that handle or store mixed transuranic (TRU) waste operated by contractors for the US Department of Energy (DOE). While approaches to estimating on-site and off-site consequences of hypothetical accidents differ, there are commonalities in all of the safety studies. This paper identifies key parameters and methods used to estimate the radiological consequences associated with release of waste forms under abnormal conditions. Specific facilities are identified by letters with their safety studies listed in a bibliography rather than as specific references so that similarities and differences are emphasized in a nonjudgmental manner. References are provided for specific parameters used to project consequences associated with compromise of barriers and dispersion of potentially hazardous materials. For all of the accidents and sites, estimated dose commitments are well below guidelines even using highly conservative assumptions. Some of the studies quantified the airborne concentrations of toxic materials; this paper only addresses these analyses briefly, as an entire paper could be dedicated to this subject.

Courtney, J. C.; Dwight, C. C.; Forrester, R. J.; Lehto, M. A.; Pan, Y. C.

1999-02-10

148

Upgrading the safety toolkit: Initiatives of the accident analysis subgroup  

SciTech Connect

Since its inception, the Accident Analysis Subgroup (AAS) of the Energy Facility Contractors Group (EFCOG) has been a leading organization promoting development and application of appropriate methodologies for safety analysis of US Department of Energy (DOE) installations. The AAS, one of seven chartered by the EFCOG Safety Analysis Working Group, has performed an oversight function and provided direction to several technical groups. These efforts have been instrumental toward formal evaluation of computer models, improving the pedigree on high-use computer models, and development of the user-friendly Accident Analysis Guidebook (AAG). All of these improvements have improved the analytical toolkit for best complying with DOE orders and standards shaping safety analysis reports (SARs) and related documentation. Major support for these objectives has been through DOE/DP-45.

O'Kula, K.R.; Chung, D.Y.

1999-07-01

149

PHYSICS AND SAFETY ANALYSIS FOR THE NIST RESEARCH REACTOR  

Microsoft Academic Search

Detailed reactor physics and safety analyses have been performed for the 20 MW DO moderated research reactor (NBSR) at the National Institute of Standards and Technology (NIST). The analyses provide an update to the Final Safety Analysis Report (FSAR) and employ state-of-the-art calculational methods. Three-dimensional Monte Carlo neutron and photon transport calculations were performed with the MCNP code to determine

L. HANSON; A. DIAMOND; D. XU; J. CAREW; J. RORER

2004-01-01

150

Safety analysis report for packaging (onsite) steel drum  

SciTech Connect

This Safety Analysis Report for Packaging (SARP) provides the analyses and evaluations necessary to demonstrate that the steel drum packaging system meets the transportation safety requirements of HNF-PRO-154, Responsibilities and Procedures for all Hazardous Material Shipments, for an onsite packaging containing Type B quantities of solid and liquid radioactive materials. The basic component of the steel drum packaging system is the 208 L (55-gal) steel drum.

McCormick, W.A.

1998-09-29

151

Safety verification in Murphy using fault tree analysis  

Microsoft Academic Search

MURPHY is a language-independent, experimental methodology for building safety-critical, real time software, which will include an integrated tool set. Using Ada as an example, this paper presents a technique for verifying the safety of complex, real-time software using Software Fault Tree Analysis. The templates for Ada are presented along with an example of applying the technique to an Ada program.

Stephen S. Cha; Nancy G. Leveson; Timothy J. Shimeall

1988-01-01

152

Fault Tree and Formal Methods in System Safety Analysis  

Microsoft Academic Search

Fault tree analysis is a traditional deductive safety analysis technique that is applied during the system design stage. However, traditional fault trees often suffer from a lack of formal semantics to check the correctness or consistency of the descriptions. To overcome this limitation, we first propose a formal fault tree construction model in which the correctness of the fault tree

Jianwen Xiang; Kokichi Futatsugi; Yanxiang He

2004-01-01

153

Environmental, health, and safety analysis in the national photovoltaics program  

Microsoft Academic Search

This report reviews the role of environmental, health, and safety (EH and S) analysis in the National Photovoltaics (PV) Program and evaluates the effectiveness of such analysis in reducing possible future PV EH and S effects. The National PV Program was established by Congress to provide an alternative to conventional electrical generating sources that rely on fuels found to be

Volkmer

1985-01-01

154

Spatial Disorientation Analysis of AF Safety Center Mishap Data.  

National Technical Information Service (NTIS)

During the initial development of micro Analysis & Design's (MA&D's) Spatial Disorientation Analysis Toll (SDAT), we received seven mishap data sets from the Air Force Safety Center (AFSC). AFSC simply told us that five of the data sets were definitely SD...

J. Keller R. Small

2006-01-01

155

Three-dimensional analysis of partially open butterfly valve flows  

Microsoft Academic Search

A numerical simulation of butterfly valve flows is a useful technique to investigate the physical phenomena of the flow field. A three-dimensional numerical analysis was carried out on incompressible fluid flows in a butterfly valve by using FLUENT, which solves difference equations. Characteristics of the butterfly valve flows at different valve disk angles with a uniform incoming velocity were investigated.

Chendong Huang; Rhyn H. Kim

1996-01-01

156

Deformation and localization analysis of partially saturated soil  

Microsoft Academic Search

Deformation and localization analysis is a crucial issue and has thus been intensively investigated in the last decades. However, in contrast to solid mechanical problems, geotechnical applications do not only concern a single solid material, the soil, but they also affect the pore-fluids, water and air, and, consequently, the coupling of the solid deformation with the pore-fluid flow. As a

W. Ehlers; T. Graf; M. Ammann

2004-01-01

157

An antiproton-proton partial-wave analysis  

SciTech Connect

Partial-wave analyses (PWAs) have a long history in the fields of {pi}N and NN scattering. Due to the poor quality of low-energy antiproton beams and the resulting absence of accurate experimental data, analogous model-independent studies of the much more complex {bar p}p system have in the past always been impossible. In the pre-LEAR era spin-dependent observables and charge-exchange ({bar p}p - {bar n}n) data were almost nonexistent, the situation between 400 and 925 MeV/c is now quite good. High-quality analyzing-power data have been obtained for the elastic and charge-exchange reactions. Very recently, even charge-exchange depolarization data have become available. Unfortunately, the practical difficulties involved in constructing a high-quality ``cooled`` antiproton beam of lower momentum are large. Consequently, the {bar p}p database below about 400 MeV/c is still by far not as good as one would like, in striking contrast to the pp case where very accurate data exist as low as T{sub L} = 0.35 MeV. It also remains an outstanding experimental challenge to construct a polarized antiproton beam to further probe the spin structure of the interaction. A new method has been developed by the Nijmegen group to perform PWAs of the abundant and accurate NN scattering data below T{sub L} = 350 MeV. With the now available high-quality data from LEAR and KEK, we have been able to extend the methods used in these NN PWAs to perform an energy-dependent PWA of all {bar p}p scattering data below p{sub L} = 925 MeV/c. The same methods of PWA have also been applied to the strangeness-exchange reaction {bar p}p {yields} {bar {lambda}}{lambda}, for which the PS185 group at LEAR has obtained beautiful data. In the next section we review the theoretical ideas behind these Nijmegen PWAS, and we apply these ideas and methods to the case of {bar p}p scattering. In section IV some results of this {bar p}p PWA are presented and discussed.

Timmermans, R. [Los Alamos National Lab., NM (United States); Rijken, T.A.; de Swart, J.J. [Katholieke Univ. Nijmegen (Netherlands). Inst. for Theoretical Physics

1993-11-01

158

Safety analysis and review system (SARS) assessment report  

SciTech Connect

Under DOE Order 5481.1, Safety Analysis and Review System for DOE Operations, safety analyses are required for DOE projects in order to ensure that: (1) potential hazards are systematically identified; (2) potential impacts are analyzed; (3) reasonable measures have been taken to eliminate, control, or mitigate the hazards; and (4) there is documented management authorization of the DOE operation based on an objective assessment of the adequacy of the safety analysis. This report is intended to provide the DOE Office of Plans and Technology Assessment (OPTA) with an independent evaluation of the adequacy of the ongoing safety analysis effort. As part of this effort, a number of site visits and interviews were conducted, and FE SARS documents were reviewed. The latter included SARS Implementation Plans for a number of FE field offices, as well as safety analysis reports completed for certain FE operations. This report summarizes SARS related efforts at the DOE field offices visited and evaluates the extent to which they fulfill the requirements of DOE 5481.1.

Browne, E.T.

1981-03-01

159

Safety analysis of the existing 851 Firing Facility  

SciTech Connect

A safety analysis was performed to determine if normal operations and/or potential accidents at the 851 Firing Facility at Site 300 could present undue hazards to the general public, personnel at Site 300, or have an adverse effect on the environment. The normal operations and credible accidents that might have an effect on these facilities or have off-site consequences were considered. It was determined by this analysis that all but two of the hazards were either low or of the type or magnitude routinely encountered and/or accepted by the public. The exceptions were the linear accelerator and explosives, which were classified as moderate hazards per the requirements given in DOE Order 5481.1A. This safety analysis concluded that the operation at this facility will present no undue risk to the health and safety of LLNL employees or the public.

Odell, B.N.

1986-06-05

160

10 CFR 830.204 - Documented safety analysis.  

Code of Federal Regulations, 2013 CFR

...Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis...ii) Identifies applicable nuclear criticality safety standards, and (iii...the program meets applicable nuclear criticality safety...

2013-01-01

161

Derivatives of partial inductances for the sensitivity analysis in PEEC systems  

Microsoft Academic Search

When applying the adjoint sensitivity analysis to an electromagnetic (EM) field solver, the derivatives of the system matrix elements with respect to the design parameters have to be computed. In this paper the partial element equivalent circuit (PEEC) method is utilized in the magneto-quasi-static regime where the system matrix elements represent partial resistances and inductances. Closed-form solutions for the derivatives

Peter Scholz; Wolfgang Ackermann; Thomas Weiland

2010-01-01

162

Socioeconomic Considerations in Dam Safety Risk Analysis.  

National Technical Information Service (NTIS)

The analytical review and summary critique of literature related to risk analysis was conducted for the purpose of highlighting those ideas, concepts and methods that have a bearing on conventional approaches to evaluating uncertainties of natural and tec...

H. C. Cochrane R. Ferrell-Dillard D. D. Baumann

1987-01-01

163

FFTF Final Safety Analysis Report Amendment 81 [SEC 1 & 2  

SciTech Connect

Since the last reactor operation of FFTF in March of 1992, the FFTF has either been in a programmatic status of Standby or Shutdown. The facility hazards have decreased markedly. Rather than making extensive Final Safety Analysis Report (FSAR) changes, Appendix G was prepared to reflect the design and operation during Standby or Shutdown. Appendix G describes the application of the entire FSAR for the current configuration, accounting for the natural reduction in hazards and new system configurations associated with Standby/Shutdown. The technical system chapters and the safety analysis chapter of the FSAR describe how the design and operation fulfilled the requirements necessary to support reactor operation; this information is retained for design basis and historical information. This Final Safety Analysis Report (FSAR) is submitted per the requirements of Paragraph 014, Energy Research and Development Administration (ERDA) Manual Chapter 0540, ''Safety of ERDA-Owned Reactors.'' This FSAR and its supporting documentation provide a complete description and safety evaluation of the site, plant design, normal and emergency operations, potential accidents and predicted consequences of such accidents, and the means that will prevent such accidents and/or reduce their consequences to an acceptable level.

DAUTEL, W.A.

2002-01-10

164

75 FR 69648 - Safety Analysis Requirements for Defining Adequate Protection for the Public and the Workers  

Federal Register 2010, 2011, 2012, 2013

...Requirements for Defining Adequate Protection...AGENCY: Defense Nuclear Facilities Safety...Secretary of Energy requesting an...SECRETARY OF ENERGY Safety Analysis Requirements for Defining Adequate Protection...5) Atomic Energy Act of 1954...Energy's (DOE) nuclear safety...

2010-11-15

165

75 FR 74022 - Safety Analysis Requirements for Defining Adequate Protection for the Public and the Workers  

Federal Register 2010, 2011, 2012, 2013

...Requirements for Defining Adequate Protection...AGENCY: Defense Nuclear Facilities Safety...Secretary of Energy requesting an...Secretary of Energy Safety Analysis Requirements for Defining Adequate Protection...5), Atomic Energy Act of 1954...Energy's (DOE) nuclear safety...

2010-11-30

166

Safety analysis of SISL process module  

SciTech Connect

This report provides an assessment of various postulated accidental occurrences within an experimental process module which is part of a Special Isotope Separation Laboratory (SISL) currently under construction at the Lawrence Livermore National Laboratory (LLNL). The process module will contain large amounts of molten uranium and various water-cooled structures within a vacuum vessel. Special emphasis is therefore given to potential accidental interactions of molten uranium with water leading to explosive and/or rapid steam formation, as well as uranium oxidation and the potential for combustion. Considerations are also given to the potential for vessel melt-through. Evaluations include mechanical and thermal interactions and design implications both in terms of design basis as well as once-in-a-lifetime accident scenarios. These scenarios include both single- and multiple-failure modes leading to various contact modes and locations within the process module for possible thermal interactions. The evaluations show that a vacuum vessel design based upon nominal operating conditions would appear sufficient to meet safety requirements in connection with both design basis as well as once-in-a-lifetime accidents. Controlled venting requirements for removal of steam and hydrogen in order to avoid possible long-term pressurization events are recommended. Depending upon the resulting accident conditions, the vacuum system (i.e., the roughing system) could also serve this purpose. Finally, based upon accident evaluations of this study, immediate shut-off of all coolant water following an incident leak is not recommended, as such action may have adverse effects in terms of cool-down requirements for the melt crucibles etc. These requirements have not been assessed as part of this study.

Not Available

1983-05-01

167

Selenium yeast: Composition, quality, analysis, and safety  

Microsoft Academic Search

Selenium yeast, produced by growing select strains of Saccharomyces cerevisiae in Se-rich media, is a recognized source of organic food-form Se, but the determination of its exact composition with respect to the Se species present produced conflicting results. Improved methods of analysis have since revealed it to contain 90+ % of its Se in the form of selenomethionine, the principal

G. N. Schrauzer

2006-01-01

168

Safety analysis of optically ignited explosive and pyrotechnic devices  

SciTech Connect

The future of optical ordnance depends on the acceptance, validation and verification of the stated safety enhancement claims of optical ordnance over existing electrical explosive devices (EED`s). Sandia has been pursuing the development of optical ordnance, with the primary motivation of this effort being the enhancement of explosive safety by specifically reducing the potential of premature detonation that can occur with low energy electrically ignited explosive devices. By using semiconductor laser diodes for igniting these devices, safety improvements can be made without being detrimental to current system concerns since the inputs required for these devices are similar to electrical systems. Laser Diode Ignition (LDI) of the energetic material provides the opportunity to remove the bridgewire and electrically conductive pins from the charge cavity, creating a Faraday cage and thus isolating the explosive or pyrotechnic materials from stray electrical ignition sources. Recent results from our continued study of safety enhancements are presented. The areas of investigation which are presented include: (1) unintended optical source analysis, specifically lightning insensitivity, (2) electromagnetic radiation (EMR) and electrostatic discharge (ESD) insensitivity analysis, and (3) powder safety.

Merson, J.A.; Salas, F.J.; Holswade, S.

1994-05-01

169

SAFETY OF MELOXICAM: A GLOBAL ANALYSIS OF CLINICAL TRIALS  

Microsoft Academic Search

SUMMARY Meloxicam is a new preferential cyclooxygenase-2 (COX-2) inhibitor for the treatment of rheumatic disease. This paper presents a global safety analysis of data from meloxicam clinical studies, focusing on gastrointestinal (GI) adverse events. Meloxicam 7.5 and 15 mg (n = 893 and 3282) were compared with piroxicam 20 mg (n = 906), diclofenac 100 mg slow release (n =

M. DISTEL; J. FRIES

1996-01-01

170

Safety Analysis for Packaging Steel Banded Wooden Shipping Containers  

Microsoft Academic Search

This safety analysis report for packaging describes the steel banded wooden shipping containers, which are certified as Type AF packagings. The authorized payload for these containers is unirradiated, slightly enriched, uranium ingots, billets, extrusions, and scrap materials. The amount of uranium in the containers will not exceed the LSA-II material requirements as defined in 49 CFR 173.403.

2000-01-01

171

Activation analysis for ITER safety and environmental assessment  

SciTech Connect

A systematic approach to neutronics and activation calculations is conceived for the ITER design and safety analysis. Specifications of these calculations are described. Results relevant to the activation characteristics of a shielding blanket based ITER are discussed. Possible options to reduce the decay heat and long-term radioactivities are revealed. 9 refs., 4 figs., 4 tabs.

Cheng, E.T. [TSI Research, INC., Solana Beach, CA (United States); Saji, G. [ITER San Diego Joint Work Site, La Jolla, CA (United States)

1996-12-31

172

Safety analysis, 200 Area, Savannah River Plant: Separations area operations  

Microsoft Academic Search

Analysis of the Savannah River Plant RBOF and RRF included an evaluation of the reliability of process equipment and controls, administrative controls, and engineered safety features. The evaluation also identified potential scenarios and radiological consequences. Risks were calculated in terms of 50-year population dose commitment per year (man-rem\\/year) to the onsite and offsite population within an 80 Km radius of

1983-01-01

173

Nuclear Safety Analysis of a Molten Salt Breeder Reactor  

Microsoft Academic Search

An analysis is made of the nuclear safety of a Molten Salt Breeder Reactor (MSBR) using one point kinetics model, with particular attention to the fact that the MSBR, operating on U-Th with circulating fuel, has a very small effective delayed neutron fraction, which is conducive to a very high power increase being induced by reactivity addition, particularly when applied

Yoichiro SHIMAZU

1978-01-01

174

FFTF Final Safety Analysis Report Amendment 81 [SEC 1 & 2  

Microsoft Academic Search

Since the last reactor operation of FFTF in March of 1992, the FFTF has either been in a programmatic status of Standby or Shutdown. The facility hazards have decreased markedly. Rather than making extensive Final Safety Analysis Report (FSAR) changes, Appendix G was prepared to reflect the design and operation during Standby or Shutdown. Appendix G describes the application of

2002-01-01

175

Implementation of the Generic Safety Analysis Report - Lessons Learned  

SciTech Connect

The Savannah River Site has completed the development, review and approval process for the Generic Safety Analysis Report (GSAR) and implemented this information in facility SARs and BIOs. This includes the yearly revision of the GSAR and the facility-specific SARs. The process has provided us with several lessons learned.

Blanchard, A.

1999-06-02

176

Safety Analysis for Packaging Steel Banded Wooden Shipping Containers  

SciTech Connect

This safety analysis report for packaging describes the steel banded wooden shipping containers, which are certified as Type AF packagings. The authorized payload for these containers is unirradiated, slightly enriched, uranium ingots, billets, extrusions, and scrap materials. The amount of uranium in the containers will not exceed the LSA-II material requirements as defined in 49 CFR 173.403.

FERRELL, P.C.

2000-12-05

177

SNF fuel retrieval sub project safety analysis document.  

National Technical Information Service (NTIS)

This safety analysis is for the SNF Fuel Retrieval (FRS) Sub Project. The FRS equipment will be added to K West and K East Basins to facilitate retrieval, cleaning and repackaging the spent nuclear fuel into Multi-Canister Overpack baskets. The document i...

D. W. Bergmann

1999-01-01

178

[Safety analysis for astronaut and the personal protective equipment].  

PubMed

Objective. To analyze and study astronaut and his personal equipment safety. Method. Three of the most widely used approaches, failure mode and effect analysis (FMEA), fault tree analysis (FTA) and system hazards analysis (SHA) were used. Result. It was demonstrated that astronaut and the personal equipment are subjected to various potential hazards, such as human errors, astronaut illness, fire or space suit emergency decompression, etc. Their causes, mechanisms, possible effects and criticality of some critical potential hazards were analyzed and identified in more details with considerations of the historic accidents of manned spaceflight. And the compensating provisions and preventive measures for each hazard were discussed. Conclusion. The analysis study may be helpful in enhancing the safety of the astronaut and its personal protective equipment. PMID:12434807

Chen, J D; Sun, J B; Shi, H P; Sun, H L

1999-12-01

179

Safety analysis results for cryostat ingress accidents in ITER  

SciTech Connect

Accidents involving the ingress of air or water into the cryostat of the International Thermonuclear Experimental Reactor (ITER) tokamak design have been analyzed with a modified version of the MELCOR code for the ITER Non-site Specific Safety Report (NSSR-1). The air ingress accident is the result of a postulated breach of the cryostat boundary into an adjoining room. MELCOR results for this accident demonstrate that the condensed air mass and increased heat loads are not a magnet safety concern, but that the partial vacuum in the adjoining room must be accommodated in the building design. The water ingress accident is the result of a postulated magnet arc that results in melting of a Primary Heat Transport System (PHTS) coolant pipe, discharging PHTS water and PHTS water activated corrosion products and HTO into the cryostat. MELCOR results for this accident demonstrate that the condensed water mass and increased heat loads are not a magnet safety concern, that the cryostat pressure remains below design limits, and that the corrosion product and HTO releases are well within the ITER release limits.

Merrill, B.J.; Cadwallader, L.C.; Petti, D.A.

1996-12-31

180

Safety analysis of plasma anomaly consequences in fusion reactors  

Microsoft Academic Search

Plasma anomaly consequences in the ITER-CDA (International Thermonuclear Experimental Reactor-Conceptual Design Activity) reactor have been investigated by using a comprehensive safety analysis code for fusion reactors. In this paper, the analysis results are shown for power excursion, disruptions, ex-vessel LOCA and dust production due to disruption. The code will be modified to apply it to the ITER-EDA (Engineering Design Activity)

T. Honda; T. Okazaki; Y. Seki; T. Kunugi; I. Aoki

1995-01-01

181

A Content Analysis of Safety Behaviors of Television Characters: Implications for Children's Safety and Injury1  

Microsoft Academic Search

Examined frequency and characteristics of safety behaviors in television programs popular with child audiences. A sample of52 programs was coded for safety event loca- tion, demographic characteristics of safety models, social and physical contexts of safety events, and successful or unsuccessful outcomes of safety behaviors. Results indicate an overall rate of 13 safety behaviors per hour, with over half of

Richard Potts; Duane Runyan; Anne Zerger; Kenneth Marchetti

1996-01-01

182

Fuel Storage Facility Final Safety Analysis Report. Revision 1  

SciTech Connect

The Fuel Storage Facility (FSF) is an integral part of the Fast Flux Test Facility. Its purpose is to provide long-term storage (20-year design life) for spent fuel core elements used to provide the fast flux environment in FFTF, and for test fuel pins, components and subassemblies that have been irradiated in the fast flux environment. This Final Safety Analysis Report (FSAR) and its supporting documentation provides a complete description and safety evaluation of the site, the plant design, operations, and potential accidents.

Linderoth, C.E.

1984-03-01

183

Safety analysis report for packaging (onsite) multicanister overpack cask  

SciTech Connect

This safety analysis report for packaging (SARP) documents the safety of shipments of irradiated fuel elements in the MUlticanister Overpack (MCO) and MCO Cask for a highway route controlled quantity, Type B fissile package. This SARP evaluates the package during transfers of (1) water-filled MCOs from the K Basins to the Cold Vacuum Drying Facility (CVDF) and (2) sealed and cold vacuum dried MCOs from the CVDF in the 100 K Area to the Canister Storage Building in the 200 East Area.

Edwards, W.S.

1997-07-14

184

Safety risk analysis of an innovative environmental technology.  

PubMed

The authors describe a decision and risk analysis performed for the cleanup of a large Department of Energy mixed-waste subsurface disposal area governed by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). In a previous study, the authors worked with the site decision makers, state regulators, and U.S. Environmental Protection Agency regional regulators to develop a CERCLA-based multiobjective decision analysis value model and used the model to perform a screening analysis of 28 remedial alternatives. The analysis results identified an innovative technology, in situ vitrification, with high effectiveness versus cost. Since this technology had not been used on this scale before, the major uncertainties were contaminant migration and pressure buildup. Pressure buildup was a safety concern due to the potential risks to worker safety. With the help of environmental technology experts remedial alternative changes were identified to mitigate the concerns about contaminant migration and pressure buildup. The analysis results showed that the probability of an event with a risk to worker safety had been significantly reduced. Based on these results, site decision makers have refocused their test program to examine in situ vitrification and have continued the use of the CERCLA-based decision analysis methodology to analyze remedial alternatives. PMID:11332543

Parnell, G S; Frimpon, M; Barnes, J; Kloeber, J M; Deckro, R E; Jackson, J A

2001-02-01

185

Worker Safety and Health and Nuclear Safety Quarterly Performance Analysis (January - March 2008)  

SciTech Connect

The DOE Office of Enforcement expects LLNL to 'implement comprehensive management and independent assessments that are effective in identifying deficiencies and broader problems in safety and security programs, as well as opportunities for continuous improvement within the organization' and to 'regularly perform assessments to evaluate implementation of the contractor's processes for screening and internal reporting.' LLNL has a self-assessment program, described in ES&H Manual Document 4.1, that includes line, management and independent assessments. LLNL also has in place a process to identify and report deficiencies of nuclear, worker safety and health and security requirements. In addition, the DOE Office of Enforcement expects LLNL to evaluate 'issues management databases to identify adverse trends, dominant problem areas, and potential repetitive events or conditions' (page 14, DOE Enforcement Process Overview, December 2007). LLNL requires that all worker safety and health and nuclear safety noncompliances be tracked as 'deficiencies' in the LLNL Issues Tracking System (ITS). Data from the ITS are analyzed for worker safety and health (WSH) and nuclear safety noncompliances that may meet the threshold for reporting to the DOE Noncompliance Tracking System (NTS). This report meets the expectations defined by the DOE Office of Enforcement to review the assessments conducted by LLNL, analyze the issues and noncompliances found in these assessments, and evaluate the data in the ITS database to identify adverse trends, dominant problem areas, and potential repetitive events or conditions. The report attempts to answer three questions: (1) Is LLNL evaluating its programs and state of compliance? (2) What is LLNL finding? (3) Is LLNL appropriately managing what it finds? The analysis in this report focuses on data from the first quarter of 2008 (January through March). This quarter is analyzed within the context of information identified in previous quarters to include April 2007 through March 2008. The results from analyzing the deficiencies are presented in accordance with the two primary NTS reporting thresholds for WSH and nuclear safety noncompliances: (1) those related to certain events or conditions and (2) those that are management issues. In addition, WSH noncompliances were also analyzed to determine if any fell under the 'other significant condition' threshold. This report also identifies noncompliance topical areas that may have issues that do not meet the NTS reporting threshold but should remain under observation. These are placed on the 'watch list' for continued analysis.

Kerr, C E

2009-10-07

186

CONACS: the DOE safety analysis system  

SciTech Connect

The CONtainment Analysis Code System (CONACS) is a large, comprehensive scientific simulation system for predicting conditions in an LMR facility following the occurrence of a postulated accident. It has now been developed to a stage of completion that can be referred to as a limited operational version. This version forms a permanent portion of the ultimate system. Because CONACS was developed with change in mind, it is now possible to draw on this strength to respond to changing requirements arising from advanced design concepts. The generalized design applications in the nuclear and non-nuclear fields and the quality assurance applied to the project make those adaptations reliable. In this paper the results of prototype tests and the implications of limited version tests are presented along with a brief description of CONACS and its relationship to LMR design optimization and cost reduction.

Martin, F.J.; Armstrong, G.R.; Niccoli, L.G.

1985-03-01

187

Style, content and format guide for writing safety analysis documents. Volume 1, Safety analysis reports for DOE nuclear facilities  

SciTech Connect

The purpose of Volume 1 of this 4-volume style guide is to furnish guidelines on writing and publishing Safety Analysis Reports (SARs) for DOE nuclear facilities at Sandia National Laboratories. The scope of Volume 1 encompasses not only the general guidelines for writing and publishing, but also the prescribed topics/appendices contents along with examples from typical SARs for DOE nuclear facilities.

Not Available

1994-06-01

188

PAT-1 safety analysis report addendum.  

SciTech Connect

The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The purpose of this SAR Addendum is to incorporate plutonium (Pu) metal as a new payload for the PAT-1 package. The Pu metal is packed in an inner container (designated the T-Ampoule) that replaces the PC-1 inner container. The documentation and results from analysis contained in this addendum demonstrate that the replacement of the PC-1 and associated packaging material with the T-Ampoule and associated packaging with the addition of the plutonium metal content are not significant with respect to the design, operating characteristics, or safe performance of the containment system and prevention of criticality when the package is subjected to the tests specified in 10 CFR 71.71, 71.73 and 71.74.

Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

2010-09-01

189

Partial unmixing as a tool for single surface class detection and time series analysis  

Microsoft Academic Search

In this paper we present the results of time series analysis for a coal mining region based on partial unmixing. We test the method also known as mixture tuned matched filtering on an eight image Landsat 5 TM and Landsat 7 ETM+ time series covering the period from 1987 to 2003. Common change detection methods often include the comparison of

C. Kuenzer; M. Bachmann; A. Mueller; L. Lieckfeld; W. Wagner

2008-01-01

190

Comparative study of various normal mode analysis techniques based on partial Hessians.  

PubMed

Standard normal mode analysis becomes problematic for complex molecular systems, as a result of both the high computational cost and the excessive amount of information when the full Hessian matrix is used. Several partial Hessian methods have been proposed in the literature, yielding approximate normal modes. These methods aim at reducing the computational load and/or calculating only the relevant normal modes of interest in a specific application. Each method has its own (dis)advantages and application field but guidelines for the most suitable choice are lacking. We have investigated several partial Hessian methods, including the Partial Hessian Vibrational Analysis (PHVA), the Mobile Block Hessian (MBH), and the Vibrational Subsystem Analysis (VSA). In this article, we focus on the benefits and drawbacks of these methods, in terms of the reproduction of localized modes, collective modes, and the performance in partially optimized structures. We find that the PHVA is suitable for describing localized modes, that the MBH not only reproduces localized and global modes but also serves as an analysis tool of the spectrum, and that the VSA is mostly useful for the reproduction of the low frequency spectrum. These guidelines are illustrated with the reproduction of the localized amine-stretch, the spectrum of quinine and a bis-cinchona derivative, and the low frequency modes of the LAO binding protein. PMID:19813181

Ghysels, An; Van Speybroeck, Veronique; Pauwels, Ewald; Catak, Saron; Brooks, Bernard R; Van Neck, Dimitri; Waroquier, Michel

2010-04-15

191

Partial wave analysis of DM2 data in the eta(1430) energy range.  

National Technical Information Service (NTIS)

Partial Wave Analysis of the J/(psi) yields (gamma)K(sub S)(sup 0)K(sup (+-))(pi)(sup -+), (gamma)K(sup (+-))K(sup -+)(pi)(sup 0) decays in the (iota)/(eta)(1430) mass range shows a clear pseudoscalar dominance, with two dynamical components. The main one...

J. E. Augustin G. Cosme F. Couchot F. Fulda G. Grosdidier

1990-01-01

192

Partial wave analysis of iota/eta (1430) from DM2.  

National Technical Information Service (NTIS)

A Partial Wave Analysis of the (iota)/(eta) (1430) region from the study of the radiative decays J/(Psi) (yields) (gamma) K(sub S)(sup 0)K(sup (plus minus))(pi)(sup -+) and J/(Psi) (yields) (gamma) K(sup (plus minus))K(sup -+) (pi)(sup 0) is presented. Ps...

J. E. Augustin G. Cosme F. Couchot F. Fulda G. Grosdidier

1989-01-01

193

Investigating Importance Weighting of Satisfaction Scores from a Formative Model with Partial Least Squares Analysis  

ERIC Educational Resources Information Center

|This study introduced a formative model to investigate the utility of importance weighting on satisfaction scores with partial least squares analysis. Based on the bottom-up theory of satisfaction evaluations, the measurement structure for weighted/unweighted domain satisfaction scores was modeled as a formative model, whereas the measurement…

Wu, Chia-Huei; Chen, Lung Hung; Tsai, Ying-Mei

2009-01-01

194

Lacosamide adjunctive therapy for partial-onset seizures: a meta-analysis  

PubMed Central

Background. The relative efficacy and safety of lacosamide as adjunctive therapy compared to other antiepileptic drugs has not been well established. Objective. To determine if lacosamide provides improved efficacy and safety, reduced length of hospital stay and improved quality of life compared with other anti-epileptic therapies for adults with partial-onset seizures. Data Sources. A systematic review of the medical literature using Medline (1946–Week 4, 2012), EMBASE (1980–Week 3, 2012), Cochrane Central Register of Controlled Trials (Issue 1 of 12, January 2012). Additional studies were identified (through to February 7, 2012) by searching bibliographies, the FDA drug approval files, clinical trial registries and major national and international neurology meeting abstracts. No restrictions on publication status or language were applied. Study Selection. Randomized controlled trials of lacosamide in adults with partial-onset seizures were included. Data Extraction. Study selection, extraction and risk of bias assessment were performed independently by two authors. Authors of studies were contacted for missing data. Data Synthesis. All pooled analyses used the random effects model. Results. Three trials (1311 patients) met inclusion criteria. Lacosamide increased the 50% responder rate compared to placebo (RR 1.68 [95% CI 1.36 to 2.08]; I2 = 0%). Discontinuation due to adverse events was statistically significantly higher in the lacosamide arm (RR3.13 [95% CI 1.94 to 5.06]; I2 = 0%). Individual adverse events (ataxia, dizziness, fatigue, and nausea) were also significantly higher in the lacosamide group. Limitations. All dosage arms from the included studies were pooled to make a single pair-wise comparison to placebo. Selective reporting of outcomes was found in all of the included RCTs. Conclusions. Lacosamide as adjunctive therapy in patients with partial-onset seizures increases the 50% responder rate but with significantly more adverse events compared to the placebo.

Newman, Jennifer J.; Deshpande, Santosh; Jones, Philip M.

2013-01-01

195

Partial-photoelectron-wave analysis in diatomic molecule photoionization by fluorescence polarization experiments  

SciTech Connect

Parameters {beta}1 and {beta}2 describing the angular distribution of circularly polarized fluorescence photons emitted by randomly oriented diatomic molecules excited by circularly polarized radiation are derived. We prove theoretically that measuring these parameters allows a partial-wave analysis of the emitted photoelectrons in the case of closed-shell diatomic molecules. The determination of the relative partial cross sections for emission of the {epsilon}{sigma}, {epsilon}{pi}, and {epsilon}{delta} photoelectrons is of fundamental importance for a sensitive test of corresponding calculations.

Demekhin, Ph. V. [Institute of Physics and CINSaT, University of Kassel, D-34132 Kassel (Germany); Rostov State University of Transport Communications, 344038 Rostov-on-Don (Russian Federation); Petrov, I. D. [Rostov State University of Transport Communications, 344038 Rostov-on-Don (Russian Federation); Ehresmann, A. [Institute of Physics and CINSaT, University of Kassel, D-34132 Kassel (Germany)

2010-10-15

196

Fluid-solid coupling analysis of safety of waterproof gate  

Microsoft Academic Search

A FLAC-3D fluid-solid numerical simulation was performed to analyze the stability and anti-water ability of the waterproof gate. Analysis indicates that under water pressure 10.3MPa, the structure of underground chamber of waterproof gate and surrounding rock mass are under plastic state partially, but are basically stable and usable. In case of water filling in the tunnel, water seepage amount is

Yubao Zhan; Chunan You; Xuanke Bi

2011-01-01

197

Methods and criteria for safety analysis (FIN L2535)  

SciTech Connect

In response to the NRC request for a proposal dated October 20, 1992, Westinghouse Savannah River Company (WSRC) submit this proposal to provide contractural assistance for FIN L2535, ``Methods and Criteria for Safety Analysis,`` as specified in the Statement of Work attached to the request for proposal. The Statement of Work involves development of safety analysis guidance for NRC licensees, arranging a workshop on this guidance, and revising NRC Regulatory Guide 3.52. This response to the request for proposal offers for consideration the following advantages of WSRC in performing this work: Experience, Qualification of Personnel and Resource Commitment, Technical and Organizational Approach, Mobilization Plan, Key Personnel and Resumes. In addition, attached are the following items required by the NRC: Schedule II, Savannah River Site - Job Cost Estimate, NRC Form 189, Project and Budget Proposal for NRC Work, page 1, NRC Form 189, Project and Budget Proposal for NRC Work, page 2, Project Description.

Not Available

1992-12-01

198

An analysis of the nucleon spectrum from lattice partially-quenched QCD  

SciTech Connect

The chiral extrapolation of the nucleon mass, Mn, is investigated using data coming from 2-flavour partially-quenched lattice simulations. The leading one-loop corrections to the nucleon mass are derived for partially-quenched QCD. A large sample of lattice results from the CP-PACS Collaboration is analysed, with explicit corrections for finite lattice spacing artifacts. The extrapolation is studied using finite range regularised chiral perturbation theory. The analysis also provides a quantitative estimate of the leading finite volume corrections. It is found that the discretisation, finite-volume and partial quenching effects can all be very well described in this framework, producing an extrapolated value of Mn in agreement with experiment. This procedure is also compared with extrapolations based on polynomial forms, where the results are less encouraging.

Armour, Wes; Allton, Chris; Leinweber, Derek; Thomas, Anthony; Young, Ross

2009-01-01

199

Safety analysis report for packaging (onsite) sample pig transport system  

SciTech Connect

This Safety Analysis Report for Packaging (SARP) provides a technical evaluation of the Sample Pig Transport System as compared to the requirements of the U.S. Department of Energy, Richland Operations Office (RL) Order 5480.1, Change 1, Chapter III. The evaluation concludes that the package is acceptable for the onsite transport of Type B, fissile excepted radioactive materials when used in accordance with this document.

MCCOY, J.C.

1999-03-16

200

Global analysis of gastrointestinal safety of a new nsaid, meloxicam  

Microsoft Academic Search

Meloxicam is a new preferential cyclo-oxygenase-2 inhibitor. This paper presents a global safety analysis of data from meloxicam\\u000a clinical studies, focusing on gastrointestinal (GI) adverse events. Meloxicam 7.5 mg and 15 mg (n=893 and 3282) were compared with piroxicam 20 mg (n=906), diclofenac 100 mg slow release (n=324) and naproxen 750–1000 mg (n=243). With respect to all GI adverse events,

M. Sistel; C. Mueller; E. Bluhmki

1996-01-01

201

Safety analysis of small long life CANDLE fast reactor  

Microsoft Academic Search

Safety analysis for small long life fast CANDLE reactor was performed with ULOF (unprotected loss of flow), SDRW (unprotected shut down rods withdrawal), ULOHS (unprotected loss of heat sink) and LB (local blockage) accidents. The employed reactor system is based on the former steady state research. The core with 1.0m radius and 2.0m length produces 200MW thermal power in steady

Mingyu Yan; Hiroshi Sekimoto

2008-01-01

202

Safety analysis, risk assessment, and risk acceptance criteria  

SciTech Connect

This paper discusses a number of topics that relate safety analysis as documented in the Department of Energy (DOE) safety analysis reports (SARs), probabilistic risk assessments (PRA) as characterized primarily in the context of the techniques that have assumed some level of formality in commercial nuclear power plant applications, and risk acceptance criteria as an outgrowth of PRA applications. DOE SARs of interest are those that are prepared for DOE facilities under DOE Order 5480.23 and the implementing guidance in DOE STD-3009-94. It must be noted that the primary area of application for DOE STD-3009 is existing DOE facilities and that certain modifications of the STD-3009 approach are necessary in SARs for new facilities. Moreover, it is the hazard analysis (HA) and accident analysis (AA) portions of these SARs that are relevant to the present discussions. Although PRAs can be qualitative in nature, PRA as used in this paper refers more generally to all quantitative risk assessments and their underlying methods. HA as used in this paper refers more generally to all qualitative risk assessments and their underlying methods that have been in use in hazardous facilities other than nuclear power plants. This discussion includes both quantitative and qualitative risk assessment methods. PRA has been used, improved, developed, and refined since the Reactor Safety Study (WASH-1400) was published in 1975 by the Nuclear Regulatory Commission (NRC). Much debate has ensued since WASH-1400 on exactly what the role of PRA should be in plant design, reactor licensing, `ensuring` plant and process safety, and a large number of other decisions that must be made for potentially hazardous activities. Of particular interest in this area is whether the risks quantified using PRA should be compared with numerical risk acceptance criteria (RACs) to determine whether a facility is `safe.` Use of RACs requires quantitative estimates of consequence frequency and magnitude.

Jamali, K. [Dept. of Energy, Germantown, MD (United States). Core Technical Support and Facility Transition; Stack, D.W.; Sullivan, L.H.; Sanzo, D.L. [Los Alamos National Lab., NM (United States)

1997-08-01

203

Safety culture and accident analysis--a socio-management approach based on organizational safety social capital.  

PubMed

One of the biggest challenges for organizations in today's competitive business environment is to create and preserve a self-sustaining safety culture. Typically, the key drivers of safety culture in many organizations are regulation, audits, safety training, various types of employee exhortations to comply with safety norms, etc. However, less evident factors like networking relationships and social trust amongst employees, as also extended networking relationships and social trust of organizations with external stakeholders like government, suppliers, regulators, etc., which constitute the safety social capital in the Organization--seem to also influence the sustenance of organizational safety culture. Can erosion in safety social capital cause deterioration in safety culture and contribute to accidents? If so, how does it contribute? As existing accident analysis models do not provide answers to these questions, CAMSoC (Curtailing Accidents by Managing Social Capital), an accident analysis model, is proposed. As an illustration, five accidents: Bhopal (India), Hyatt Regency (USA), Tenerife (Canary Islands), Westray (Canada) and Exxon Valdez (USA) have been analyzed using CAMSoC. This limited cross-industry analysis provides two key socio-management insights: the biggest source of motivation that causes deviant behavior leading to accidents is 'Faulty Value Systems'. The second biggest source is 'Enforceable Trust'. From a management control perspective, deterioration in safety culture and resultant accidents is more due to the 'action controls' rather than explicit 'cultural controls'. Future research directions to enhance the model's utility through layering are addressed briefly. PMID:16911855

Rao, Suman

2006-06-28

204

Partial-wave analysis for elastic p{sup 13}C scattering at astrophysical energies  

SciTech Connect

A standard partial-wave analysis was performed on the basis of known measurements of differential cross sections for elastic p{sup 13}C scattering at energies in the range 250-750 keV. This analysis revealed that, in the energy range being considered, it is sufficient to take into account the {sup 3}S{sub 1} wave alone. A potential for the triplet {sup 3}S{sub 1}-wave state of the p{sup 13}C system in the region of the J{sup p}T = 1{sup -1} resonance at 0.55 MeV was constructed on the basis of the phase shifts obtained from the aforementioned partial-wave analysis.

Dubovichenko, S. B., E-mail: dubovichenko@mail.ru [V.G. Fessenkov Astrophysical Institute (Kazakhstan)

2012-03-15

205

Dominating Clasp of the Financial Sector Revealed by Partial Correlation Analysis of the Stock Market  

PubMed Central

What are the dominant stocks which drive the correlations present among stocks traded in a stock market? Can a correlation analysis provide an answer to this question? In the past, correlation based networks have been proposed as a tool to uncover the underlying backbone of the market. Correlation based networks represent the stocks and their relationships, which are then investigated using different network theory methodologies. Here we introduce a new concept to tackle the above question—the partial correlation network. Partial correlation is a measure of how the correlation between two variables, e.g., stock returns, is affected by a third variable. By using it we define a proxy of stock influence, which is then used to construct partial correlation networks. The empirical part of this study is performed on a specific financial system, namely the set of 300 highly capitalized stocks traded at the New York Stock Exchange, in the time period 2001–2003. By constructing the partial correlation network, unlike the case of standard correlation based networks, we find that stocks belonging to the financial sector and, in particular, to the investment services sub-sector, are the most influential stocks affecting the correlation profile of the system. Using a moving window analysis, we find that the strong influence of the financial stocks is conserved across time for the investigated trading period. Our findings shed a new light on the underlying mechanisms and driving forces controlling the correlation profile observed in a financial market.

Kenett, Dror Y.; Tumminello, Michele; Madi, Asaf; Gur-Gershgoren, Gitit; Mantegna, Rosario N.; Ben-Jacob, Eshel

2010-01-01

206

Dominating clasp of the financial sector revealed by partial correlation analysis of the stock market.  

PubMed

What are the dominant stocks which drive the correlations present among stocks traded in a stock market? Can a correlation analysis provide an answer to this question? In the past, correlation based networks have been proposed as a tool to uncover the underlying backbone of the market. Correlation based networks represent the stocks and their relationships, which are then investigated using different network theory methodologies. Here we introduce a new concept to tackle the above question--the partial correlation network. Partial correlation is a measure of how the correlation between two variables, e.g., stock returns, is affected by a third variable. By using it we define a proxy of stock influence, which is then used to construct partial correlation networks. The empirical part of this study is performed on a specific financial system, namely the set of 300 highly capitalized stocks traded at the New York Stock Exchange, in the time period 2001-2003. By constructing the partial correlation network, unlike the case of standard correlation based networks, we find that stocks belonging to the financial sector and, in particular, to the investment services sub-sector, are the most influential stocks affecting the correlation profile of the system. Using a moving window analysis, we find that the strong influence of the financial stocks is conserved across time for the investigated trading period. Our findings shed a new light on the underlying mechanisms and driving forces controlling the correlation profile observed in a financial market. PMID:21188140

Kenett, Dror Y; Tumminello, Michele; Madi, Asaf; Gur-Gershgoren, Gitit; Mantegna, Rosario N; Ben-Jacob, Eshel

2010-12-20

207

Management implementation plan for a safety analysis and review system  

SciTech Connect

The US Department of Energy has issued an Order, DOE 5481.1, which establishes uniform requirements for the preparation and review of Safety Analysis for DOE Operations. The Management Implementation Plan specified herein establishes the administrative procedures and technical requirements for implementing DOE 5481.1 to Operations under the cognizance of the Pittsburgh Energy Technology Center. This Implementation Plan is applicable to all present and future Operations under the cognizance of PETC. The Plan identifies those Operations for which DOE 5481.1 is applicable and those Operations for which no further analysis is required because the initial determination and review has concluded that DOE 5481.1 does not apply.

Hulburt, D.A.; Berkey, B.D.

1981-04-01

208

Safety and immunogenicity of single dose of tetanus-diphtheria (Td) vaccine among non/partially immune children against diphtheria and/or tetanus, Hyderabad, India, 2007.  

PubMed

In Hyderabad, India, diphtheria is common among children aged 5-19 years. On account of low coverage of diphtheria vaccine boosters recommended under the universal immunization programme, a large proportion of children were susceptible/partially immune against diphtheria and/or tetanus. We evaluated immunogenicity and safety of single dose of indigenously developed tetanus-diphtheria (Td) vaccine (diphtheria-toxoid < or =5 Lf) among 483 school children from Hyderabad aged 7-17 years and susceptible/partially immune against diphtheria and/or tetanus. Serological testing 6 weeks after vaccination indicated that vaccine was highly immunogenic with >96% sero-protected against both antigens. The immune response observed indicated a booster response to previously acquired immunity. Administration of additional dose of Td vaccine to the older school children and replacing the tetanus toxoid vaccine with Td in the school health programme would considerably reduce diphtheria burden in Hyderabad. PMID:20620169

Bitragunta, Sailaja; Murhekar, Manoj V; Chakravarti, Anita; Verma, Vikas; Namjoshi, Gajanan S; Parekh, Sameer S; Sharma, Hitt J; Kumar, B Kishore; Gupte, Mohan D

2010-07-08

209

A fuzzy logic methodology for fault-tree analysis in critical safety systems  

SciTech Connect

A new approach for fault-tree analysis in critical safety systems employing fuzzy sets for information representation is presented in this paper. The methodology is based on the utilization of the extension principle for mapping crisp measurements to various degrees of membership in the fuzzy set of linguistic Truth. Criticality alarm systems are used in miscellaneous nuclear fuel processing, handling, and storage facilities to reduce the risk associated with fissile material operations. Fault-tree methodologies are graphic illustrations of tile failure logic associated with the development of a particular system failure (top event) from basic subcomponent failures (primary events). The term event denotes a dynamic change of state that occurs to system elements, which may include hardware, software, human, or environmental factors. A fault-tree represents a detailed, deductive, analysis that requires extensive system information. The knowledge incorporated in a fault tree can be articulated in logical rules of the form [open quotes]IF A is true THEN B is true.[close quotes] However, it is well known that this type of syllogism fails to give an answer when the satisfaction of the antecedent clause is only partial. Zadeh suggested a new type of fuzzy conditional inference. This type of syllogism (generalized modus ponens) reads as follows: Premise: A is partially true Implication: IF A is true THEN B is true Conclusion: B is partially-true. In generalized modus ponens, the antecedent is true only to some degree; hence, it is desired to compute the grade to which the consequent is satisfied. Fuzzy sets provide a natural environment for this type of computation because fuzzy variables (e.g., B) can take fuzzy values (e.g., partially-true).

Erbay, A.; Ikonomopoulos, A. (Univ. of Tennessee, Knoxville (United States))

1993-01-01

210

Safety analysis, 200 Area, Savannah River Plant: Separations area operations  

SciTech Connect

The nev HB-Line, located on the fifth and sixth levels of Building 221-H, is designed to replace the aging existing HB-Line production facility. The nev HB-Line consists of three separate facilities: the Scrap Recovery Facility, the Neptunium Oxide Facility, and the Plutonium Oxide Facility. There are three separate safety analyses for the nev HB-Line, one for each of the three facilities. These are issued as supplements to the 200-Area Safety Analysis (DPSTSA-200-10). These supplements are numbered as Sup 2A, Scrap Recovery Facility, Sup 2B, Neptunium Oxide Facility, Sup 2C, Plutonium Oxide Facility. The subject of this safety analysis, the, Plutonium Oxide Facility, will convert nitrate solutions of {sup 238}Pu to plutonium oxide (PuO{sub 2}) powder. All these new facilities incorporate improvements in: (1) engineered barriers to contain contamination, (2) barriers to minimize personnel exposure to airborne contamination, (3) shielding and remote operations to decrease radiation exposure, and (4) equipment and ventilation design to provide flexibility and improved process performance.

Perkins, W.C.; Lee, R.; Allen, P.M.; Gouge, A.P.

1991-07-01

211

Thermohydraulic and Safety Analysis for CARR Under Station Blackout Accident  

SciTech Connect

A thermohydraulic and safety analysis code (TSACC) has been developed using Fortran 90 language to evaluate the transient thermohydraulic behaviors and safety characteristics of the China Advanced Research Reactor(CARR) under Station Blackout Accident(SBA). For the development of TSACC, a series of corresponding mathematical and physical models were considered. Point reactor neutron kinetics model was adopted for solving reactor power. All possible flow and heat transfer conditions under station blackout accident were considered and the optional models were supplied. The usual Finite Difference Method (FDM) was abandoned and a new model was adopted to evaluate the temperature field of core plate type fuel element. A new simple and convenient equation was proposed for the resolution of the transient behaviors of the main pump instead of the complicated four-quadrant model. Gear method and Adams method were adopted alternately for a better solution to the stiff differential equations describing the dynamic behaviors of the CARR. The computational result of TSACC showed the enough safety margin of CARR under SBA. For the purpose of Verification and Validation (V and V), the simulated results of TSACC were compared with those of Relap5/Mdo3. The V and V result indicated a good agreement between the results by the two codes. Because of the adoption of modular programming techniques, this analysis code is expected to be applied to other reactors by easily modifying the corresponding function modules. (authors)

Wenxi Tian; Suizheng Qiu; Guanghui Su; Dounan Jia [Xi'an Jiaotong University, 28 Xianning Road, Xi'an 710049 (China); Xingmin Liu - China Institute of Atomic Energy

2006-07-01

212

Simplifying documentation while approaching site closure: integrated health & safety plans as documented safety analysis  

Microsoft Academic Search

At the Fernald Closure Project (FCP) near Cincinnati, Ohio, environmental restoration activities are supported by Documented Safety Analyses (DSAs) that combine the required project-specific Health and Safety Plans, Safety Basis Requirements (SBRs), and Process Requirements (PRs) into single Integrated Health and Safety Plans (I-HASPs). By isolating any remediation activities that deal with Enriched Restricted Materials, the SBRs and PRs assure

Tulanda

2003-01-01

213

The Feature Extraction Based on Nonlinear Partial Orthogonal Analysis with B-Spline Function for Signal of Vibrational Sensors  

Microsoft Academic Search

The new method of feature extraction based on nonlinear partial orthogonal analysis with B-spline function for signal of vibrational sensors is proposed in the paper. Firstly, the nonlinear signal is mapped into linear space; then, the signal is analyzed in the linear space; finally, a set of eigenvalue vectors are obtained with nonlinear partial orthogonal analysis. The vectors reflect a

Liu Gui-Guo; Yue Bin; Huang Dao; Huang Hai-Yan

2008-01-01

214

Reactor Accident Analysis Methodology for the Advanced Test Reactor Critical Facility Documented Safety Analysis Upgrade  

SciTech Connect

The regulatory requirement to develop an upgraded safety basis for a DOE nuclear facility was realized in January 2001 by issuance of a revision to Title 10 of the Code of Federal Regulations Section 830 (10 CFR 830).1 Subpart B of 10 CFR 830, “Safety Basis Requirements,” requires a contractor responsible for a DOE Hazard Category 1, 2, or 3 nuclear facility to either submit by April 9, 2001 the existing safety basis which already meets the requirements of Subpart B, or to submit by April 10, 2003 an upgraded facility safety basis that meets the revised requirements.1 10 CFR 830 identifies Nuclear Regulatory Commission (NRC) Regulatory Guide 1.70, “Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants”2 as a safe harbor methodology for preparation of a DOE reactor documented safety analysis (DSA). The regulation also allows for use of a graded approach. This report presents the methodology that was developed for preparing the reactor accident analysis portion of the Advanced Test Reactor Critical Facility (ATRC) upgraded DSA. The methodology was approved by DOE for developing the ATRC safety basis as an appropriate application of a graded approach to the requirements of 10 CFR 830.

Gregg L. Sharp; R. T. McCracken

2003-06-01

215

Reactor Accident Analysis Methodology for the Advanced Test Reactor Critical Facility Documented Safety Analysis Upgrade  

SciTech Connect

The regulatory requirement to develop an upgraded safety basis for a DOE Nuclear Facility was realized in January 2001 by issuance of a revision to Title 10 of the Code of Federal Regulations Section 830 (10 CFR 830). Subpart B of 10 CFR 830, ''Safety Basis Requirements,'' requires a contractor responsible for a DOE Hazard Category 1, 2, or 3 nuclear facility to either submit by April 9, 2001 the existing safety basis which already meets the requirements of Subpart B, or to submit by April 10, 2003 an upgraded facility safety basis that meets the revised requirements. 10 CFR 830 identifies Nuclear Regulatory Commission (NRC) Regulatory Guide 1.70, ''Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants'' as a safe harbor methodology for preparation of a DOE reactor documented safety analysis (DSA). The regulation also allows for use of a graded approach. This report presents the methodology that was developed for preparing the reactor accident analysis portion of the Advanced Test Reactor Critical Facility (ATRC) upgraded DSA. The methodology was approved by DOE for developing the ATRC safety basis as an appropriate application of a graded approach to the requirements of 10 CFR 830.

Sharp, G.L.; McCracken, R.T.

2003-05-13

216

A Simple Air-Side Data Analysis Method for Partially Wet Flat-Tube Heat Exchangers  

Microsoft Academic Search

An air-side data analysis method is developed for flat-tube heat exchangers under partially wet conditions. In order to simplify the combined sensible and latent heat transfer, it is assumed that condensate drainage paths develop such that, at steady state, water does not spread to noncondensing surfaces, which therefore remain dry. The air dew point is compared to local fin-tip and

Young-Gil Park; Anthony M. Jacobi

2011-01-01

217

Thermodynamic analysis and conceptual design for partial coal gasification air preheating coal-fired combined cycle  

Microsoft Academic Search

The partial coal gasification air pre-heating coal-fired combined cycle (PGACC) is a cleaning coal power system, which integrates\\u000a the coal gasification technology, circulating fluidized bed technology, and combined cycle technology. It has high efficiency\\u000a and simple construction, and is a new selection of the cleaning coal power systems. A thermodynamic analysis of the PGACC\\u000a is carried out. The effects of

Yue Xu; Yining Wu; Shimin Deng; Shirang Wei

2004-01-01

218

Homotopy analysis method for solving a class of fractional partial differential equations  

NASA Astrophysics Data System (ADS)

In this paper, the homotopy analysis method is applied to obtain the solution of fractional partial differential equations with spatial and temporal fractional derivatives in Riesz and Caputo senses, respectively. Some properties of Riesz fractional derivative utilized in obtaining the series solution are proved. Numerical examples demonstrate the effect of changing homotopy auxiliary parameter ? on the convergence of the approximate solution. Also, they illustrate the effect of the fractional derivative orders ? and ? on the solution behavior.

Elsaid, A.

2011-09-01

219

Analysis of Safety from a Human Clinical Trial with Pterostilbene  

PubMed Central

Objectives. The purpose of this trial was to evaluate the safety of long-term pterostilbene administration in humans. Methodology. The trial was a prospective, randomized, double-blind placebo-controlled intervention trial enrolling patients with hypercholesterolemia (defined as a baseline total cholesterol ?200?mg/dL and/or baseline low-density lipoprotein cholesterol ?100?mg/dL). Eighty subjects were divided equally into one of four groups: (1) pterostilbene 125?mg twice daily, (2) pterostilbene 50?mg twice daily, (3) pterostilbene 50?mg + grape extract (GE) 100?mg twice daily, and (4) matching placebo twice daily for 6–8 weeks. Safety markers included biochemical and subjective measures. Linear mixed models were used to estimate primary safety measure treatment effects. Results. The majority of patients completed the trial (91.3%). The average age was 54 years. The majority of patients were females (71%) and Caucasians (70%). There were no adverse drug reactions (ADRs) on hepatic, renal, or glucose markers based on biochemical analysis. There were no statistically significant self-reported or major ADRs. Conclusion. Pterostilbene is generally safe for use in humans up to 250?mg/day.

Riche, Daniel M.; McEwen, Corey L.; Riche, Krista D.; Sherman, Justin J.; Wofford, Marion R.; Deschamp, David; Griswold, Michael

2013-01-01

220

Analysis of safety from a human clinical trial with pterostilbene.  

PubMed

Objectives. The purpose of this trial was to evaluate the safety of long-term pterostilbene administration in humans. Methodology. The trial was a prospective, randomized, double-blind placebo-controlled intervention trial enrolling patients with hypercholesterolemia (defined as a baseline total cholesterol ?200?mg/dL and/or baseline low-density lipoprotein cholesterol ?100?mg/dL). Eighty subjects were divided equally into one of four groups: (1) pterostilbene 125?mg twice daily, (2) pterostilbene 50?mg twice daily, (3) pterostilbene 50?mg + grape extract (GE) 100?mg twice daily, and (4) matching placebo twice daily for 6-8 weeks. Safety markers included biochemical and subjective measures. Linear mixed models were used to estimate primary safety measure treatment effects. Results. The majority of patients completed the trial (91.3%). The average age was 54 years. The majority of patients were females (71%) and Caucasians (70%). There were no adverse drug reactions (ADRs) on hepatic, renal, or glucose markers based on biochemical analysis. There were no statistically significant self-reported or major ADRs. Conclusion. Pterostilbene is generally safe for use in humans up to 250?mg/day. PMID:23431291

Riche, Daniel M; McEwen, Corey L; Riche, Krista D; Sherman, Justin J; Wofford, Marion R; Deschamp, David; Griswold, Michael

2013-02-04

221

Fast Flux Test Facility final safety analysis report. Amendment 73  

SciTech Connect

This report provides Final Safety Analysis Report (FSAR) Amendment 73 for incorporation into the Fast Flux Test Facility (FFTR) FSAR set. This page change incorporates Engineering Change Notices (ECNs) issued subsequent to Amendment 72 and approved for incorparoration before May 6, 1993. These changes include: Chapter 3, design criteria structures, equipment, and systems; chapter 5B, reactor coolant system; chapter 7, instrumentation and control systems; chapter 9, auxiliary systems; chapter 11, reactor refueling system; chapter 12, radiation protection and waste management; chapter 13, conduct of operations; chapter 17, technical specifications; chapter 20, FFTF criticality specifications; appendix C, local fuel failure events; and appendix Fl, operation at 680{degrees}F inlet temperature.

Gantt, D.A.

1993-08-01

222

Safety analysis reports for multiple hazard category facilities  

SciTech Connect

The Savannah River Site contains many nuclear facilities for which safety analysis reports (SARs) are required. The current requirements with which the SARs must comply are given in U.S. Department of Energy (DOE) Order 5480.23. This order requires use of the graded approach. The graded approach demands a more thoroughly documented assessment of complex, higher hazard facilities than simple, lower hazard facilities because grading is a function of both hazard potential and complexity. The treatment of different hazard category facilities in the development of the SAR for the Central Laboratory Facility at the Savannah River Site is described here.

Geeting, M.W.; Gerrard, P.B. [Westinghouse Electric Corporation, Pittsburgh, PA (United States)

1995-12-31

223

The Zion integrated safety analysis for NUREG-1150  

SciTech Connect

The utility-funded Zion Probabilistic Safety Study provided not only a detailed and thorough assessment of the risk profile of Zion Unit 1, but also presented substantial advancement in the technology of probabilistic risk assessment (PRA). Since performance of that study, modifications of plant hardware, the introduction of new emergency procedures, operational experience gained, information generated by severe accident research programs and further evolution of PRA and uncertainty analysis methods have provided a basis for reevaluation of the Zion risk profile. This reevaluation is discussed in this report. 5 refs.

Unwin, S.D.; Park, C.K.

1988-01-01

224

Analysis of planetary exploration spacesuit systems and evaluation of a modified partial-gravity simulation technique  

NASA Astrophysics Data System (ADS)

Building on prior experience during Apollo, NASA now plans to send humans back to the Moon and then on to Mars as part of its Vision for Space Exploration. An integral component for enabling this plan is the development of advanced spacesuit systems. A planetary exploration spacesuit system consists of an astronaut, a spacesuit, and the associated surface systems designed to enable completion of mission objectives. This thesis addresses all three aspects, beginning with an examination of the effects of locomotion stability in lunar and Mars gravity from a metabolic energy expenditure standpoint. An experiment to determine the effects of stability on running in reduced gravity was performed with a modified vertical offload partial gravity device. Operations scenarios were also developed, along with engineering analysis to understand the forces and moments involved in partial gravity locomotion. Analysis is presented to assess the applicability of terrestrial exploration systems and to adapt them for planetary exploration. Access systems for partial gravity planetary explorations are described that may allow humans in spacesuits to safely access scientifically significant terrain on the Moon and Mars. Contingency scenarios for effective rescue of astronauts from flat and sloped terrain were also analyzed. Conclusions and recommendations are offered regarding the effectiveness of the simulation technique developed. An Earth-based field testing program plan is presented with the intent of including access systems in the lunar surface system architecture requirements early enough to allow synergies in component design.

Chappell, Steven Patrick

225

Analysis of non linear partially standing waves from 3D velocity measurements  

NASA Astrophysics Data System (ADS)

Surface gravity waves in the ocean exhibit an energy spectrum distributed in both frequency and direction of propagation. Wave data collection is of great importance in coastal zones for engineering and scientific studies. In particular, partially standing waves measurements near coastal structures and steep or barred beaches may be a requirement, for instance for morphodynamic studies. The aim of the present study is the analysis of partially standing surface waves icluding non-linear effects. According to 1st order Stokes theory, synchronous measurements of horizontal and vertical velocity components allow calculation of rate of standing waves (Drevard et al, 2003). In the present study, it is demonstrated that for deep water conditions, partially standing 2nd order Stokes waves induced velocity field is still represented by the 1st order solution for the velocity potential contrary to the surface elevation which exhibits harmonic components. For intermediate water depth, harmonic components appear not only in the surface elevation but also in the velocity fields, but their weight remains much smaller, because of the vertical decreasing wave induced motion. For irregular waves, the influence of the spectrum width on the non-linear effects in the analysis is discussed. Keywords: Wave measurements ; reflection ; non-linear effects Acknowledgements: This work was initiated during the stay of Prof. Ib Svendsen, as invited Professor, at LSEET in autumn 2002. This study is carried out in the framework of the Scientific French National Programmes PNEC ART7 and PATOM. Their financial supports are acknowledged References: Drevard, D., Meuret, A., Rey, V. Piazzola, J. And Dolle, A.. (2002). "Partially reflected waves measurements using Acoustic Doppler Velocimeter (ADV)", Submitted to ISOPE 03, Honolulu, Hawaii, May 2003.

Drevard, D.; Rey, V.; Svendsen, Ib; Fraunie, P.

2003-04-01

226

The role of risk assessment and safety analysis in integrated safety assessments  

Microsoft Academic Search

To ensure that the design and operation of both nuclear and non- nuclear hazardous facilities is acceptable, and meets all societal safety expectations, a rigorous deterministic and probabilistic assessment is necessary. An approach is introduced, founded on the concept of an Integrated Safety Assessment.'' It merges the commonly performed safety and risk analyses and uses them in concert to provide

R. Niall; M. Hunt; T. E. Wierman

1990-01-01

227

PHYSICS AND SAFETY ANALYSIS FOR THE NIST RESEARCH REACTOR.  

SciTech Connect

Detailed reactor physics and safety analyses have been performed for the 20 MW D{sub 2}O moderated research reactor (NBSR) at the National Institute of Standards and Technology (NIST). The analyses provide an update to the Final Safety Analysis Report (FSAR) and employ state-of-the-art calculational methods. Three-dimensional Monte Carlo neutron and photon transport calculations were performed with the MCNP code to determine the safety parameters for the NBSR. The core depletion and determination of the fuel compositions were performed with MONTEBURNS. MCNP calculations were performed to determine the beginning, middle, and end-of-cycle power distributions, moderator temperature coefficient, and shim safety arm, beam tube and void reactivity worths. The calculational model included a plate-by-plate description of each fuel assembly, axial mid-plane water gap, beam tubes and the tubular geometry of the shim safety arms. The time-dependent analysis of the primary loop was determined with a RELAP5 transient analysis model that includes the pump, heat exchanger, fuel element geometry, and flow channels for both the six inner and twenty-four outer fuel elements. The statistical analysis used to assure protection from critical heat flux (CHF) was performed using a Monte Carlo simulation of the uncertainties contributing to the CHF calculation. The power distributions used to determine the local fuel conditions and margin to CHF were determined with MCNP. Evaluations were performed for the following accidents: (1) the control rod withdrawal startup accident, (2) the maximum reactivity insertion accident, (3) loss-of-flow resulting from loss of electrical power, (4) loss-of-flow resulting from a primary pump seizure, (5) loss-of-flow resulting from inadvertent throttling of a flow control valve, (6) loss-of-flow resulting from failure of both shutdown cooling pumps and (7) misloading of a fuel element. In both the startup and maximum reactivity insertion accidents, the core power transient is terminated by a reactor trip at 26 MW. The calculations show that both the peak reactor power and the excursion energy depend on the negative reactivity insertion from reactor trip. In one of the loss-of-flow accidents offsite electrical power is assumed lost to the three operating primary pumps. A slightly delayed reactor scram is initiated as a result of primary flow coast down. The RELAP5 results indicate that there is adequate margin to CHF and no damage to the fuel will occur, because of the momentum of the coolant flowing through the fuel channels and the negative scram reactivity insertion. For both the primary pump seizure and inadvertent throttling of a flow control valve, the RELAP5 analyses indicate that the reduction in power following the trip is sufficient to ensure that there is adequate margin to CHF and that the fuel cladding does not fail. The analysis of the loss-of-flow accident in the extremely unlikely case where both shutdown pumps fail, shows that the cooling provided by the D{sub 2}O is sufficient to ensure the cladding does not fail. The power distributions were examined for a set of fuel misloadings in which a fresh fuel element is moved from a peripheral low-reactivity location to a central high-reactivity location. The calculations show that there is adequate margin to CHF and the cladding does not fail. An additional analysis was performed to simulate the operation at low power (500 kW) without forced flow cooling. The result indicates that natural convection cooling is adequate for operation of the NBSR at a power level of 500 kW.

CHENG,L.HANSON,A.DIAMOND,D.XU,J.CAREW,J.RORER,D.

2004-03-31

228

Survey of systems safety analysis methods and their application to nuclear waste management systems  

NASA Astrophysics Data System (ADS)

This report reviews system safety analysis methods and examines their application to nuclear waste management systems. The safety analysis methods examined include expert opinion, maximum credible accident approach, design basis accidents approach, hazard indices, preliminary hazards analysis, failure modes and effects analysis, fault trees, event trees, cause consequence diagrams, GO methodology, Markov modeling, and a general category of consequence analysis models. Previous and ongoing studies on the safety of waste management systems are discussed along with their limitations and potential improvements. The major safety methods and waste management safety related studies are surveyed. This survey provides information on what safety methods are available, what waste management safety areas have been analyzed, and what are potential areas for future study.

Pelto, P. J.; Winegardner, W. K.; Gallucci, R. H. V.

1981-11-01

229

Safety analysis and review system. Phase I. Final report  

SciTech Connect

This report summarizes work completed in support of the implementation of the DOE Safety Analysis and Review System (SARS). It is intended to describe and summarize critical items identified during the course of this study and discussed in previous reports completed for other subtasks under this contract. The following were among the issues identified as requiring further overview, assessment, and action by DOE: (1) there needs to be firm guidance from DOE Headquarters (HQ) in regard to SARS-related responsibilities and requirements of the DOE field offices; (2) a system must be established to track the applicability and progress of SARS for individual DOE operations. Currently, it is difficult, if not impossible, to identify projects with SARS requirements in their contracts. Thus, it is difficult to set accurate schedules for safety analysis reviews; (3) a decision must be made by DOE officials as to whether review authority for moderate risk projects will be delegated to the field. As part of this, a detailed assessment of resources available for reviews, both at the field and HQ levels, needs to be accomplished; and (4) to be implemented effectively, SARS needs to be incorporated into the overall DOE project management system.

Browne, E.T.

1981-03-01

230

Limited-scope probabilistic safety analysis for the Los Alamos Meson Physics Facility (LAMPF)  

SciTech Connect

The reliability of instrumentation and safety systems is a major issue in the operation of accelerator facilities. A probabilistic safety analysis was performed or the key safety and instrumentation systems at the Los Alamos Meson Physics Facility (LAMPF). in Phase I of this unique study, the Personnel Safety System (PSS) and the Current Limiters (XLs) were analyzed through the use of the fault tree analyses, failure modes and effects analysis, and criticality analysis. Phase II of the program was done to update and reevaluate the safety systems after the Phase I recommendations were implemented. This paper provides a brief review of the studies involved in Phases I and II of the program.

Sharirli, M.; Rand, J.L.; Sasser, M.K.; Gallegos, F.R.

1992-01-01

231

Limited-scope probabilistic safety analysis for the Los Alamos Meson Physics Facility (LAMPF)  

SciTech Connect

The reliability of instrumentation and safety systems is a major issue in the operation of accelerator facilities. A probabilistic safety analysis was performed or the key safety and instrumentation systems at the Los Alamos Meson Physics Facility (LAMPF). in Phase I of this unique study, the Personnel Safety System (PSS) and the Current Limiters (XLs) were analyzed through the use of the fault tree analyses, failure modes and effects analysis, and criticality analysis. Phase II of the program was done to update and reevaluate the safety systems after the Phase I recommendations were implemented. This paper provides a brief review of the studies involved in Phases I and II of the program.

Sharirli, M.; Rand, J.L.; Sasser, M.K.; Gallegos, F.R.

1992-12-01

232

Documented Safety Analysis for the B695 Segment  

SciTech Connect

This Documented Safety Analysis (DSA) was prepared for the Lawrence Livermore National Laboratory (LLNL) Building 695 (B695) Segment of the Decontamination and Waste Treatment Facility (DWTF). The report provides comprehensive information on design and operations, including safety programs and safety structures, systems and components to address the potential process-related hazards, natural phenomena, and external hazards that can affect the public, facility workers, and the environment. Consideration is given to all modes of operation, including the potential for both equipment failure and human error. The facilities known collectively as the DWTF are used by LLNL's Radioactive and Hazardous Waste Management (RHWM) Division to store and treat regulated wastes generated at LLNL. RHWM generally processes low-level radioactive waste with no, or extremely low, concentrations of transuranics (e.g., much less than 100 nCi/g). Wastes processed often contain only depleted uranium and beta- and gamma-emitting nuclides, e.g., {sup 90}Sr, {sup 137}Cs, or {sup 3}H. The mission of the B695 Segment centers on container storage, lab-packing, repacking, overpacking, bulking, sampling, waste transfer, and waste treatment. The B695 Segment is used for storage of radioactive waste (including transuranic and low-level), hazardous, nonhazardous, mixed, and other waste. Storage of hazardous and mixed waste in B695 Segment facilities is in compliance with the Resource Conservation and Recovery Act (RCRA). LLNL is operated by the Lawrence Livermore National Security, LLC, for the Department of Energy (DOE). The B695 Segment is operated by the RHWM Division of LLNL. Many operations in the B695 Segment are performed under a Resource Conservation and Recovery Act (RCRA) operation plan, similar to commercial treatment operations with best demonstrated available technologies. The buildings of the B695 Segment were designed and built considering such operations, using proven building systems, and keeping them as simple as possible while complying with industry standards and institutional requirements. No operations to be performed in the B695 Segment or building system are considered to be complex. No anticipated future change in the facility mission is expected to impact the extent of safety analysis documented in this DSA.

Laycak, D

2008-09-11

233

Canister storage building (CSB) safety analysis report phase 3: Safety analysis documentation supporting CSB construction  

SciTech Connect

The Canister Storage Building (CSB) will be constructed in the 200 East Area of the U.S. Department of Energy (DOE) Hanford Site. The CSB will be used to stage and store spent nuclear fuel (SNF) removed from the Hanford Site K Basins. The objective of this chapter is to describe the characteristics of the site on which the CSB will be located. This description will support the hazard analysis and accident analyses in Chapter 3.0. The purpose of this report is to provide an evaluation of the CSB design criteria, the design's compliance with the applicable criteria, and the basis for authorization to proceed with construction of the CSB.

Garvin, L.J.

1997-04-28

234

Numerical analysis of a SNOM tip based on a partially cladded optical fiber.  

PubMed

A Scanning Nearfield Optical Microscope (SNOM) tip with partial metallic cladding is presented. For its design, a very demanding 2D eigenvalue analysis of an optical waveguide with material and radiation losses is carried out by the Multiple Multipole Program (MMP) and by the Finite Element Method (FEM). These simulations require some special tricks that are outlined. The computed 2D MMP and FEM results are compared and discussed. This 2D analysis is followed by a full 3D FEM analysis of the SNOM tip. The obtained 3D results confirm the corresponding 2D predictions. Important conclusions regarding the guiding capabilities of the chosen structure and the efficiency of the applied numerical methods are presented. PMID:22109194

Smajic, Jasmin; Hafner, Christian

2011-11-01

235

Multivariate analysis of patient satisfaction factors affecting the usage of removable partial dentures.  

PubMed

The purpose of this retrospective cohort study was to investigate patient satisfaction factors that affect the usage of removable partial dentures (RPDs) using a multivariate analysis. Sixty-seven patients, who had RPDs inserted at the Tohoku University Hospital between 1996 and 2001, participated in this study. Data were collected from patients' clinical records and a questionnaire. Of the 15 factors examined, significant associations were found between RPD usage and pain, color of the artificial teeth, and arrangement of the artificial teeth. These findings suggest that RPD usage is related to patient satisfaction with esthetics and an absence of pain. PMID:19149065

Koyama, Shigeto; Sasaki, Keiichi; Kawata, Tetsuo; Atsumi, Tomohiro; Watanabe, Makoto

236

Partial wave analysis of K/sup +/ anti K/sub S/. pi. /sup -/ final state  

SciTech Connect

A partial wave analysis of high statistics data collected by AGS Experiment No. 771 in reaction ..pi../sup -/p ..-->.. K/sup +/ anti K/sub S/..pi../sup -/ + n shows evidence for a 1/sup + +/ and a 0/sup - +/ state in the 1280 MeV region, a 0/sup - +/ state in the 1420 MeV region and a 1/sup + +/ state in the 1500 MeV region. Preliminary data from reaction K/sup -/p ..-->.. K/sup +/ anti K/sub S/..pi../sup -/ + X are presented.

Protopopescu, S.D.

1987-06-19

237

Partial-wave analysis of the low-mass  

Microsoft Academic Search

Summary  A partial-wave analysis of the\\u000a $$\\\\overline {K^0 } \\\\pi ^ + \\\\pi ^ - $$\\u000a system in the mass range\\u000a $${\\\\rm M}(\\\\overline {K^0 } \\\\pi ^ + \\\\pi ^ - )< 1.6GeV$$\\u000a is presented for data at 3.95 and 14.3 GeV\\/c. We find important contributions from theJ\\u000a \\u000a P\\u000a =0? and 1+ states, the unnatural spin-parity states accounting for more than

B. Drevillon; S. Borenstein; B. Chaurand; J. M. Gago; A. Rouge; R. A. Salmeron; H. Videau; A. Borg; D. Denegri; Y. Pons; M. Spiro; K. Paler; C. Comber; S. N. Tovey; T. P. Shah

1976-01-01

238

Criticality safety analysis of a calciner exit chute  

SciTech Connect

Calcination of uranyl nitrate into uranium oxide is part of normal operations of some enrichment plants. Typically, a calciner discharges uranium oxide powder (U[sub 3]O[sub 8]) into an exit chute that directs the powder into a receiving can located in a glove box. One possible scenario for a criticality accident is the exit chute becoming blocked with powder near its discharge. The blockage restricts the flow of powder causing the exit chute to become filled with the powder. If blockage does occur, the height of the powder could reach a level that would not be safe from a criticality point of view. In this analysis, the subcritical height limit is examined for 98% enriched U[sub 3]O[sub 8] in the exit chute with full water reflection and optimal water moderation. The height limit for ensuring criticality safety during such an accumulation is 28.2 cm above the top of the discharge pipe at the bottom of the chute. Chute design variations are also evaluated with full water reflection and optimal water moderation. Subcritical configurations for the exit chute variation are developed, but the configurations are not safe when combined with the calciner. To ensure criticality safety, modifications must be made to the calciner tube or safety measures must be implemented if these designs are to be utilized with 98% enriched material. A geometrically safe configuration for the exit chute is developed for a blockage of 20% enriched powder with full water reflection and optimal water moderation, and this configuration is safe when combined with the existing calciner.

Haught, C.F.; Basoglu, B.; Brewer, R.W.; Hollenback, D.F.; Wilkinson, A.D.; Dodds, H.L. (Univ. of Tennessee, Knoxville, TN (United States). Nuclear Engineering Dept.); Oxenham, R.L. (Martin Marietta Utility Services, Piketon, OH (United States))

1994-01-01

239

A Model-Oriented Approach to Safety Analysis Using Fault Trees and a Support System  

Microsoft Academic Search

Fault tree technique has been used in industry for safety analysis of safety criticalsystems for decades. They can be used for analysing the safety of both software andhardware. However, there are a lot of problems in ensuring the internal consistencyand validity of fault trees constructed due to the absence of appropriate approachof using fault tree technique. This paper describes a

Shaoying Liu; John A. Mcdermid

1996-01-01

240

Documented Safety Analysis for the Waste Storage Facilities March 2010  

SciTech Connect

This Documented Safety Analysis (DSA) for the Waste Storage Facilities was developed in accordance with 10 CFR 830, Subpart B, 'Safety Basis Requirements,' and utilizes the methodology outlined in DOE-STD-3009-94, Change Notice 3. The Waste Storage Facilities consist of Area 625 (A625) and the Decontamination and Waste Treatment Facility (DWTF) Storage Area portion of the DWTF complex. These two areas are combined into a single DSA, as their functions as storage for radioactive and hazardous waste are essentially identical. The B695 Segment of DWTF is addressed under a separate DSA. This DSA provides a description of the Waste Storage Facilities and the operations conducted therein; identification of hazards; analyses of the hazards, including inventories, bounding releases, consequences, and conclusions; and programmatic elements that describe the current capacity for safe operations. The mission of the Waste Storage Facilities is to safely handle, store, and treat hazardous waste, transuranic (TRU) waste, low-level waste (LLW), mixed waste, combined waste, nonhazardous industrial waste, and conditionally accepted waste generated at LLNL (as well as small amounts from other DOE facilities).

Laycak, D T

2010-03-05

241

Safety analysis factors for environmental restoration and decontamination and decommissioning  

SciTech Connect

Environmental restoration (ER) and facility decontamination/decommissioning (D&D) operations can be grouped into two general categories. ``Nonstationary cleanup`` or simply ``cleanup`` activities are where the operation must relocate to the site of new contaminated material at the completion of each task (i.e., the operation moves to the contaminated material). ``Stationary production`` or simply ``production`` activities are where the contaminated material is moved to a centralized location (i.e., the contaminated material is moved to the operation) for analysis, sorting, treatment, storage, and disposal. This paper addresses the issue of nonstationary cleanup design. The following are the specific assigned action items: Collect and compile a list of special safety-related ER/D&D design factors, especially ones that don`t follow DOE Order 6430.1A requirements. Develop proposal of what makes sense to recommend to designers; especially consider recommendations for short-term projects. Present proposal at the January meeting. To achieve the action items, applicable US Department of Energy (DOE) design requirements, and cleanup operations and differences from production activities are reviewed and summarized; basic safety requirements influencing design are summarized; and finally, approaches, considerations, and methods for safe, cost-effective design of cleanup activities are discussed.

Ellingson, D.R.

1993-04-01

242

Phase 2 safety analysis report: National Synchrotron Light Source  

SciTech Connect

The Phase II program was established in order to provide additional space for experiments, and also staging and equipment storage areas. It also provides additional office space and new types of advanced instrumentation for users. This document will deal with the new safety issues resulting from this extensive expansion program, and should be used as a supplement to BNL Report No. 51584 ''National Synchrotron Light Source Safety Analysis Report,'' July 1982 (hereafter referred to as the Phase I SAR). The initial NSLS facility is described in the Phase I SAR. It comprises two electron storage rings, an injection system common to both, experimental beam lines and equipment, and office and support areas, all of which are housed in a 74,000 sq. ft. building. The X-ray Ring provides for 28 primary beam ports and the VUV Ring, 16. Each port is capable of division into 2 or 3 separate beam lines. All ports receive their synchrotron light from conventional bending magnet sources, the magnets being part of the storage ring lattice. 4 refs.

Stefan, P. (ed.)

1989-06-01

243

Documented Safety Analysis for the Waste Storage Facilities  

SciTech Connect

This documented safety analysis (DSA) for the Waste Storage Facilities was developed in accordance with 10 CFR 830, Subpart B, 'Safety Basis Requirements', and utilizes the methodology outlined in DOE-STD-3009-94, Change Notice 3. The Waste Storage Facilities consist of Area 625 (A625) and the Decontamination and Waste Treatment Facility (DWTF) Storage Area portion of the DWTF complex. These two areas are combined into a single DSA, as their functions as storage for radioactive and hazardous waste are essentially identical. The B695 Segment of DWTF is addressed under a separate DSA. This DSA provides a description of the Waste Storage Facilities and the operations conducted therein; identification of hazards; analyses of the hazards, including inventories, bounding releases, consequences, and conclusions; and programmatic elements that describe the current capacity for safe operations. The mission of the Waste Storage Facilities is to safely handle, store, and treat hazardous waste, transuranic (TRU) waste, low-level waste (LLW), mixed waste, combined waste, nonhazardous industrial waste, and conditionally accepted waste generated at LLNL (as well as small amounts from other DOE facilities).

Laycak, D

2008-06-16

244

Simplifying documentation while approaching site closure: integrated health & safety plans as documented safety analysis  

SciTech Connect

At the Fernald Closure Project (FCP) near Cincinnati, Ohio, environmental restoration activities are supported by Documented Safety Analyses (DSAs) that combine the required project-specific Health and Safety Plans, Safety Basis Requirements (SBRs), and Process Requirements (PRs) into single Integrated Health and Safety Plans (I-HASPs). By isolating any remediation activities that deal with Enriched Restricted Materials, the SBRs and PRs assure that the hazard categories of former nuclear facilities undergoing remediation remain less than Nuclear. These integrated DSAs employ Integrated Safety Management methodology in support of simplified restoration and remediation activities that, so far, have resulted in the decontamination and demolition (D&D) of over 150 structures, including six major nuclear production plants. This paper presents the FCP method for maintaining safety basis documentation, using the D&D I-HASP as an example.

Brown, Tulanda

2003-06-01

245

The role of risk assessment and safety analysis in integrated safety assessments  

SciTech Connect

To ensure that the design and operation of both nuclear and non- nuclear hazardous facilities is acceptable, and meets all societal safety expectations, a rigorous deterministic and probabilistic assessment is necessary. An approach is introduced, founded on the concept of an Integrated Safety Assessment.'' It merges the commonly performed safety and risk analyses and uses them in concert to provide decision makers with the necessary depth of understanding to achieve adequacy.'' 3 refs., 1 fig.

Niall, R.; Hunt, M.; Wierman, T.E.

1990-01-01

246

Calculation of Ground Water Flow in Safety Analysis of Nuclear Waste Disposal.  

National Technical Information Service (NTIS)

Radionuclide migration in ground water is one of the most important objects in the safety analysis when the possibilities of radioactive waste disposal in the Finnish bedrock is studied. A very independent part of the safety analysis is the analysis of gr...

K. Meling

1984-01-01

247

Model-Based Safety Analysis of Simulink Models Using SCADE Design Verifier  

Microsoft Academic Search

Safety analysis techniques have traditionally been performed manually by the safety engineers. Since these analyses are based on an informal model of the system, it is unlikely that these analyses will be complete, consistent, and error-free. Using precise formal models of the system as the basis of the analysis may help reduce errors and provide a more thorough analysis. Further,

Anjali Joshi; Mats Per Erik Heimdahl

2005-01-01

248

Elucidating the structure of cyclotides by partial acid hydrolysis and LC-MS/MS analysis.  

PubMed

We describe here a rapid method to determine the cyclic structure and disulfide linkages of highly stable cyclotides via a combination of flash partial acid hydrolysis, LC-MS/MS, and computational tools. Briefly, a mixture of closely related cyclotides, kalata B1 and varv A purified from Viola yedoensis was partially hydrolyzed in 2 M HCl for 5 min by microwave-assisted hydrolysis or for 30 min in an autoclave oven (121 degrees C and 15 psi). The partially hydrolyzed peptide mixture was then subjected to LC-MS/MS analysis, with the disulfide linked-peptides fragmented by collision activated dissociation (CAD). A computer program written in-house (available for download at http://proteomics.sbs.ntu.edu.sg/cyclotide_SS ) was used for interpreting LC-MS/MS spectra and assigning the disulfide bonds. Time-point analysis of single-disulfide fragments revealed that nonrandom acid catalyzed fragmentation mostly occurred at the turns which are solvent-exposed and often contain side chain functionalized amino acids such as Asx/Glx and Ser/Thr. In particular, the most susceptible bond for acid hydrolysis in kalata B1 and varv A was found to be the highly conserved N25-G26 which is also the head-to-tail ligation site of the linear precursor proteins, indicating that formation of the three disulfide bonds might precede cyclic structure closure by N25-G26 ligation. This observation is consistent with the recent report that the N25-G26 bond formation is the last step in the cyclotide biosynthetic pathway. The process demonstrated here can potentially be a high throughput method that is generally applicable to determine disulfide bonds of other relatively low-abundance cyclotides. PMID:19178340

Sze, Siu Kwan; Wang, Wei; Meng, Wei; Yuan, Randong; Guo, Tiannan; Zhu, Yi; Tam, James P

2009-02-01

249

A meta-analysis of bird responses to uniform partial harvesting across North America.  

PubMed

Most data on the effects of partial-harvest silviculture (where live trees are purposely retained at the time of harvest) on birds come from one or a few discrete harvesting treatments. It is thus difficult to infer species responses across a continuous gradient of tree retention from individual studies. To quantify the levels of tree retention expected to produce specified changes in the relative abundance of individual species, we carried out a meta-analysis of 42 studies that examined the impacts of uniform partial harvesting on North American birds. Of 34 species, sigmoidal models showed a negative effect of harvesting for 14 species and a positive effect for 6 species. Ovenbirds (Seiurus aurocapilla) and Brown Creepers (Certhia americana) were the species most sensitive to harvesting. Most of the 14 species that were negatively affected by harvesting showed 25%, 50%, and 75% reductions in abundance (relative to control sites) at tree retention levels ranging from 45 to 85%, 30-70%, and 15-50%, respectively. A few species, such as Yellow-rumped Warblers (Dendroica coronata), exhibited these levels of response at lower tree retention or were not predicted to decrease by 75% in harvested stands. Five of the 6 species that were positively affected by harvesting showed at least a 50% increase in abundance at nearly all levels of tree retention, although other early successional bird species did not appear to benefit from the relatively small openings created by uniform partial harvesting. Three of 20 species exhibited stronger responses to harvesting at a given level of tree retention in boreal and northern mixed forests of North America than other regions of the continent, but, with these exceptions, lack of variation among forest regions supported the broad-scale generality of species' responses to harvesting. The species response models we developed represent useful tools for evaluating stand-level impacts of partial harvesting on birds within an adaptive management framework. Uniform partial harvesting at light and, to a lesser degree, moderate intensities may be effective approaches to managing habitat for late successional bird species as part of broader ecosystem-based forest management. PMID:17883488

Vanderwel, Mark C; Malcolm, Jay R; Mills, Stephen C

2007-10-01

250

Evaluating the effect of partial contributing storage on storage-discharge function from recession analysis  

NASA Astrophysics Data System (ADS)

Hydrograph recession during dry periods has been used to construct water storage-discharge relationship, and to quantify storage dynamics and evaporation when streamflow data is available. However, variable hydrologic connectivity among hillslope-riparian-stream zones may affect the lumped storage-discharge relationship, and as a result, affect the estimation of evaporation and storage change. Given observations of rainfall and runoff, and remote sensing-based observation of evaporation, the ratio (?) between estimated daily evaporation from recession analysis and observed evaporation, and the ratio (?) between estimated contributing storage and total watershed storage are computed for 9 watersheds located in different climate regions. Both evaporation and storage change estimation from recession analysis are underestimated due to the effect of partial contributing storage, particularly when the discharge is low. It was found that the values of ? decrease significantly during individual recession events, while the values of ? are relatively stable during a recession event. The values of ? are negatively correlated with the water table depth, and vary significantly among recession events. The partial contributing storage effect is one possible cause for the multi-valued storage-discharge relationship.

Chen, X.; Wang, D.

2013-05-01

251

Preliminary safety analysis of frontal collision avoidance systems  

Microsoft Academic Search

Advanced vehicle control and safety systems (AVCSS) involve several safety critical functions such as vehicle longitudinal and lateral control. INRETS (French Institute of Research in the Transports and Their Safety) and California PATH (Partners for Advanced Transit and Highways) of University of California at Berkeley collaborated to set up a common approach for developing and validating a safe operational system.

E. Miloudi; E. Koursi; Ching-Yao Chan; Wei-Bin Zhang

2000-01-01

252

Safety analysis of the 700-horsepower combustion test facility  

SciTech Connect

The objective of the program reported herein was to provide a Safety Analysis of the 700 h.p. Combustion Test Facility located in Building 93 at the Pittsburgh Energy Technology Center. Extensive safety related measures have been incorporated into the design, construction, and operation of the Combustion Test Facility. These include: nitrogen addition to the coal storage bin, slurry hopper, roller mill and pulverizer baghouse, use of low oxygen content combustion gas for coal conveying, an oxygen analyzer for the combustion gas, insulation on hot surfaces, proper classification of electrical equipment, process monitoring instrumentation and a planned remote television monitoring system. Analysis of the system considering these factors has resulted in the determination of overall probabilities of occurrence of hazards as shown in Table I. Implementation of the recommendations in this report will reduce these probabilities as indicated. The identified hazards include coal dust ignition by hot ductwork and equipment, loss of inerting within the coal conveying system leading to a coal dust fire, and ignition of hydrocarbon vapors or spilled oil, or slurry. The possibility of self-heating of coal was investigated. Implementation of the recommendations in this report will reduce the ignition probability to no more than 1 x 10/sup -6/ per event. In addition to fire and explosion hazards, there are potential exposures to materials which have been identified as hazardous to personal health, such as carbon monoxide, coal dust, hydrocarbon vapors, and oxygen deficient atmosphere, but past monitoring experience has not revealed any problem areas. The major environmental hazard is an oil spill. The facility has a comprehensive spill control plan.

Berkey, B.D.

1981-05-01

253

Safety analysis of natural gas vehicles transiting highway tunnel  

SciTech Connect

A safety analysis was performed to assess the relative hazard of compressed natural gas (CNG) fueled vehicles traveling on various tunnels and bridges in New York City. The study considered those hazards arising from the release of fuel from CNG vehicles ranging in size from a passenger sedan to a full size 53 passenger bus. The approach used was to compare the fuel hazard of CNG vehicles to the fuel hazard of gasoline vehicles. The risk was assessed by estimating the frequency of occurrence and the severity of the hazard. The methodology was a combination of analyzing accident data, performing a diffusion analysis of the gas released in the tunnel and determining the consequences of ignition. Diffusion analysis was performed using the TEMPEST code for various accident scenarios resulting in CNG release inside the Holland Tunnel. The study concluded that the overall hazard of CNG vehicles transiting a ventilated tunnel is less than the hazard from a comparable gasoline fueled vehicle. 134 refs., 23 figs., 24 tabs.

Shaaban, S.H.; Zuzovsky, M.; Anigstein, R.

1989-01-01

254

LMFBR spent fuel transport: conceptual design and partial safety analysis of a sodium-cooled cask  

Microsoft Academic Search

Conceptual designs for 6- and 18-subassembly casks are presented. The casks are intended for transport of LMFBR spent fuel which has decayed a minimum of 30 days. These casks use sodium as the primary coolant, an auxiliary shield coolant system in normal operation, heavy steel members as both gamma shield and structure, and a eutectic mixture of LiOH and NaOH

A. R. Irvine; L. B. Shappert; J. H. Evans; D. A. Canonico

1972-01-01

255

Safety review of the design, operation, and radiation sections of the General Electric Morris Operation Consolidated Safety Analysis Report  

SciTech Connect

A safety review was made of Sections 4 through 9 of the Consolidated Safety Analysis Report (CSAR) for the GE Morris Operation spent-fuel storage facility. The sections reviewed include Design Criteria and Compliance, Facility Design and Description, Radiation Protection, Accident Analysis, and Conduct of Operations. The safety review was performed in accordance with the Code of Federal Regulations, Title 10, Part 72, ''Licensing Requirements for the Storage of Spent Fuel in an Independent Spent Fuel Storage Installation'' and contains independent estimations of source terms and dose-commitments from postulated accidents in the storage facility and a structural analysis of the Morris Operation cranes as an appendix. The review confirms that the features of the facility as described in Sections 4 through 9 of the CSAR fulfilled the safety requirements of 10 CFR 72, and it is concluded that spent-fuel handling and storage at the Morris Operation do not present significant risks to public health and safety. 15 refs., 3 tabs.

McBride, J.P.

1981-01-30

256

PHYSICS AND SAFETY ANALYSIS FOR THE NIST RESEARCH REACTOR.  

SciTech Connect

Detailed reactor physics and safety analyses have been performed for the 20 MW D{sub 2}O moderated research reactor (NBSR) at the National Institute of Standards and Technology (NIST). The analyses provide an update to the Final Safety Analysis Report (FSAR) and employ state-of-the-art calculational methods. Three-dimensional MCNP Monte Carlo neutron and photon transport calculations were performed to determine the safety parameters for the NBSR. The core depletion and determination of the fuel compositions were performed with MONTEBURNS. MCNP calculations were performed to determine the beginning, middle, and end-of-cycle power distributions, moderator temperature coefficient, and shim arm, beam tube and void reactivity worths. The calculational model included a plate-by-plate description of each fuel assembly, axial mid-plane water gap, beam tubes and the tubular geometry of the shim arms. The time-dependent analysis of the primary loop was determined with a RELAP5 transient analysis model including the pump, heat exchanger, fuel element geometry, and flow channels for both the six inner and twenty-four outer fuel elements. The statistical analysis used to assure protection from critical heat flux (CHF) was performed using a Monte Carlo simulation of the uncertainties contributing to the CHF calculation. The power distributions used to determine the local fuel conditions and margin to CHF were determined with MCNP. Evaluations were performed for the following accidents: (1) the control rod withdrawal startup accident, (2) the maximum reactivity insertion accident, (3) loss-of-flow resulting from loss of electrical power, (4) loss-of-flow resulting from a primary pump seizure, (5) loss-of-flow resulting from inadvertent throttling of a flow control valve, (6) loss-of-flow resulting from failure of both shutdown cooling pumps and (7) misloading of a fuel element. In both the startup and maximum reactivity insertion accidents, the core power transient is terminated by a reactor trip at 30 MW. The calculations show that both the peak reactor power and the excursion energy depend on the negative reactivity insertion from reactor trip. Two cases were considered for loss of electrical power. In the first case offsite power is lost, resulting in an immediate scram caused by loss of power to the control rod system. In the second case power is lost to only the three operating primary pumps, resulting in a slightly delayed scram when loss-of-flow is detected as the pumps coast down. In both instances, RELAP5 results indicate that there is adequate margin to CHF and no damage to the fuel will occur, because of the momentum of the coolant flowing through the fuel channels and the negative scram reactivity insertion. For both the primary pump seizure and inadvertent throttling of a flow control valve, the RELAP5 analyses indicate that the reduction in power following the trip is sufficient to ensure that there is adequate margin to CHF and the fuel cladding does not fail. The analysis of the loss-of-flow accident in the extremely unlikely case where both shutdown pumps fail shows that the cooling provided by the D{sub 2}O is sufficient to ensure the cladding does not fail. The power distributions were examined for a set of fuel misloadings in which a fresh fuel element is moved from a peripheral low-reactivity location to a central high-reactivity location. The calculations show that there is adequate margin to CHF and the cladding does not fail.

CAREW,J.CHENG,L.HANSON,AXU,J.RORER,D.DIAMOND,D.

2003-08-26

257

41 CFR 102-80.105 - What information must be included in an equivalent level of safety analysis?  

Code of Federal Regulations, 2010 CFR

...equivalent level of safety analysis? The equivalent level...fire protection engineer. The analysis should include a narrative discussion of the features...protection and life safety. Each analysis should describe potential...

2009-07-01

258

41 CFR 102-80.105 - What information must be included in an equivalent level of safety analysis?  

Code of Federal Regulations, 2010 CFR

...equivalent level of safety analysis? The equivalent level...fire protection engineer. The analysis should include a narrative discussion of the features...protection and life safety. Each analysis should describe potential...

2010-07-01

259

41 CFR 102-80.105 - What information must be included in an equivalent level of safety analysis?  

Code of Federal Regulations, 2013 CFR

...equivalent level of safety analysis? The equivalent level...fire protection engineer. The analysis should include a narrative discussion of the features...protection and life safety. Each analysis should describe potential...

2013-01-01

260

Integrating safety analysis into the model-based development toolchain of automotive embedded systems  

Microsoft Academic Search

The automotive industry has a growing demand for the seamless integration of safety analysis tools into the model-based development toolchain for embedded systems. This requires translating concepts of the automotive domain to the safety domain. We automate such a translation between the automotive architecture description language EAST-ADL2 and the safety analysis tool HiP-HOPS by using model transformations and by leveraging

Matthias Biehl; Chen DeJiu; Martin Törngren

2010-01-01

261

Safety and performance analysis of a commercial photovoltaic installation  

NASA Astrophysics Data System (ADS)

Continuing to better understand the performance of PV systems and changes in performance with the system life is vital to the sustainable growth of solar. A systematic understanding of degradation mechanisms that are induced as a result of variables such as the service environment, installation, module/material design, weather, operation and maintenance, and manufacturing is required for reliable operation throughout a system's lifetime. We wish to report the results from an analysis of a commercial c-Si PV array owned and operated by DuPont. We assessed the electrical performance of the modules by comparing the original manufacturers' performance data with the measurements obtained using a solar simulator to determine the degradation rate. This evaluation provides valuable PV system field experience and document key issues regarding safety and performance. A review of the nondestructive and destructive analytical methods and characterization strategies we have found useful for system, module, and subsequent material component evaluations are presented. We provide an overview of our inspection protocol and subsequent control process to mitigate risk. The objective is to explore and develop best practice protocols regarding PV asset optimization and provide a rationale to reduce risk based on the analysis of our own commercial installations.

Hamzavy, Babak T.; Bradley, Alexander Z.

2013-09-01

262

A probabilistic safety analysis of incidents in nuclear research reactors.  

PubMed

This work aims to evaluate the potential risks of incidents in nuclear research reactors. For its development, two databases of the International Atomic Energy Agency (IAEA) were used: the Research Reactor Data Base (RRDB) and the Incident Report System for Research Reactor (IRSRR). For this study, the probabilistic safety analysis (PSA) was used. To obtain the result of the probability calculations for PSA, the theory and equations in the paper IAEA TECDOC-636 were used. A specific program to analyse the probabilities was developed within the main program, Scilab 5.1.1. for two distributions, Fischer and chi-square, both with the confidence level of 90 %. Using Sordi equations, the maximum admissible doses to compare with the risk limits established by the International Commission on Radiological Protection (ICRP) were obtained. All results achieved with this probability analysis led to the conclusion that the incidents which occurred had radiation doses within the stochastic effects reference interval established by the ICRP-64. PMID:22021060

Lopes, Valdir Maciel; Agostinho Angelo Sordi, Gian Maria; Moralles, Mauricio; Filho, Tufic Madi

2011-10-20

263

Impedance analysis for oxygen reduction in lithium carbonate melt: Effect of partial pressure of oxygen  

SciTech Connect

Effects of partial pressure of oxygen and temperature on oxygen reduction kinetics on a submerged gold electrode in lithium carbonate melt were investigated using cyclic voltammetry and impedance analysis. Cyclic voltammetry measurements indicated that the oxygen reduction reaction in Li{sub 2}CO{sub 3} melt is reversible up to 200 mV/s. The impedance analysis was carried out using a Complex Nonlinear Least Square (CNLS) paxameter estimation program based on the Randles-Ershler equivalent circlet. This analysis technique was used to estimate the electrode kinetics and the mass transfer related parameters such as the charge transfer resistance (R{sub ct}) and the Warburg coefficient {sigma}. The mass transfer related parameters obtained from cyclic voltammetry and impedance analysis were in good agreement. The reaction orders for oxygen at 800{degrees}C were calculated to be 0.38 for the exchange current density and 0.5 for the product D{sub o}{sup {1/2}}C{sub o}*; these values are consistent with the mechanism proposed in the literature for oxygen reduction in Li{sub 2}CO{sub 3} melt on a submerged gold electrode.

Dave, B.B.; White, R.E.; Srinivasan, S.; Appleby, A.J.

1989-12-31

264

Impedance analysis for oxygen reduction in lithium carbonate melt: Effect of partial pressure of oxygen  

SciTech Connect

Effects of partial pressure of oxygen and temperature on oxygen reduction kinetics on a submerged gold electrode in lithium carbonate melt were investigated using cyclic voltammetry and impedance analysis. Cyclic voltammetry measurements indicated that the oxygen reduction reaction in Li{sub 2}CO{sub 3} melt is reversible up to 200 mV/s. The impedance analysis was carried out using a Complex Nonlinear Least Square (CNLS) paxameter estimation program based on the Randles-Ershler equivalent circlet. This analysis technique was used to estimate the electrode kinetics and the mass transfer related parameters such as the charge transfer resistance (R{sub ct}) and the Warburg coefficient {sigma}. The mass transfer related parameters obtained from cyclic voltammetry and impedance analysis were in good agreement. The reaction orders for oxygen at 800{degrees}C were calculated to be 0.38 for the exchange current density and 0.5 for the product D{sub o}{sup {1/2}}C{sub o}*; these values are consistent with the mechanism proposed in the literature for oxygen reduction in Li{sub 2}CO{sub 3} melt on a submerged gold electrode.

Dave, B.B.; White, R.E.; Srinivasan, S.; Appleby, A.J.

1989-01-01

265

Safety classification and special design criteria development application guide. Safety Analysis Report Update Program.  

National Technical Information Service (NTIS)

This document is a pilot application guide to the identification of Safety class Items (SCIs) and the development of associated special design criteria. It is intended to interpret, apply, and supplement, where necessary, DOE orders and guidance to make a...

1992-01-01

266

Computer Programs for Safety Analysis: HISAFE (Highway Safety Evaluation Program) Users Manual and Operators Guide.  

National Technical Information Service (NTIS)

The report documents the 'Highway Safety Evaluation Program' (HISAFE) computer program. It contains information to the user on how to install, start up, and operate all of the program functions. It also describes the structure, functional design and capab...

T. K. Datta J. E. Hummer J. Green

1987-01-01

267

DEVELOPMNET STRATEGY OF THE ROAD SAFETY SURVEY AND ANALYSIS VEHICLE : ROSSAV  

Microsoft Academic Search

The objective of this research is to develop a strategy to build a mobile system which can be useful for the road safety analysis. Most commonly used data for the road safety analysis are road geometric information. In order to collect and analyze road geometric data, various sensors were tested and installed to collect position data, attitude data, and image

Chunjoo YOON; Donghoon JEONG; Junggon SUNG

268

1972 preliminary safety analysis report based on a conceptual design of a proposed repository in Kansas  

Microsoft Academic Search

This preliminary safety analysis report is based on a proposed Federal Repository at Lyons, Kansas, for receiving, handling, and depositing radioactive solid wastes in bedded salt during the remainder of this century. The safety analysis applies to a hypothetical site in central Kansas identical to the Lyons site, except that it is free of nearby salt solution-mining operations and bore

Blomeke

1977-01-01

269

Applying systems thinking concepts in the analysis of major incidents and safety culture  

Microsoft Academic Search

In recent years, investigations into major incidents often highlight poor safety culture as one of the key causal factors. These investigations are often assisted by causal analysis tools that help to ensure that the investigation and the information captured are systematic. However, current causal analysis tools are not designed to analyse dynamic complexity of major incidents and safety culture, which

Yang Miang Goh; Helen Brown; Jeffery Spickett

2010-01-01

270

Assessment of Documentation Requirements under DOE 5481.1, Safety Analysis and Review System (SARS).  

National Technical Information Service (NTIS)

This report assesses the requirements of DOE Order 5481.1, Safety Analysis and Review System for DOE Operations (SARS) in regard to maintaining SARS documentation. Under SARS, all pertinent details of the entire safety analysis and review process for each...

E. T. Browne

1981-01-01

271

Automating the Failure Modes and Effects Analysis of Safety Critical Systems  

Microsoft Academic Search

Failure modes and effects analysis (FMEA) is a classical system safety analysis technique which is currently widely used in the automotive, aerospace and other safety critical industries. In the process of an FMEA, analysts compile lists of component failure modes and try to infer the effects of those failure modes on the system. System models, typically simple engineering diagrams, assist

Yiannis Papadopoulos; David Parker; Christian Grante

2004-01-01

272

School Safety, Severe Disciplinary Actions, and School Characteristics: A Secondary Analysis of the School Survey on Crime and Safety  

ERIC Educational Resources Information Center

On the basis of a secondary analysis of survey data collected from 1,872 secondary school principals in the 2005-2006 School Survey on Crime and Safety, we examined the frequency of and reasons for severe disciplinary actions and the relationship between school characteristics and severe disciplinary actions. We found that severe disciplinary…

Han, Seunghee; Akiba, Motoko

2011-01-01

273

School Safety, Severe Disciplinary Actions, and School Characteristics: A Secondary Analysis of the School Survey on Crime and Safety  

ERIC Educational Resources Information Center

|On the basis of a secondary analysis of survey data collected from 1,872 secondary school principals in the 2005-2006 School Survey on Crime and Safety, we examined the frequency of and reasons for severe disciplinary actions and the relationship between school characteristics and severe disciplinary actions. We found that severe disciplinary…

Han, Seunghee; Akiba, Motoko

2011-01-01

274

Providing Nuclear Criticality Safety Analysis Education through Benchmark Experiment Evaluation  

SciTech Connect

One of the challenges that today's new workforce of nuclear criticality safety engineers face is the opportunity to provide assessment of nuclear systems and establish safety guidelines without having received significant experience or hands-on training prior to graduation. Participation in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and/or the International Reactor Physics Experiment Evaluation Project (IRPhEP) provides students and young professionals the opportunity to gain experience and enhance critical engineering skills.

John D. Bess; J. Blair Briggs; David W. Nigg

2009-11-01

275

Note: Multivariate system spectroscopic model using Lorentz oscillators and partial least squares regression analysis  

NASA Astrophysics Data System (ADS)

Multivariate system spectroscopic model plays important role in understanding chemometrics of ensemble under study. Here in this manuscript we discuss various approaches of modeling of spectroscopic system and demonstrate how Lorentz oscillator can be used to model any general spectroscopic system. Chemometric studies require customized templates design for the corresponding variants participating in ensemble, which generates the characteristic matrix of the ensemble under study. The typical biological system that resembles human blood tissue consisting of five major constituents i.e., alanine, urea, lactate, glucose, ascorbate; has been tested on the model. The model was validated using three approaches, namely, root mean square error (RMSE) analysis in the range of +/-5% confidence interval, clerk gird error plot, and RMSE versus percent noise level study. Also the model was tested across various template sizes (consisting of samples ranging from 10 up to 1000) to ascertain the validity of partial least squares regression. The model has potential in understanding the chemometrics of proteomics pathways.

Gad, R. S.; Parab, J. S.; Naik, G. M.

2010-11-01

276

Partial Wave Analysis at BES III, harnessing the power of GPUs  

NASA Astrophysics Data System (ADS)

Partial wave analysis (PWA) is a core tool for determining resonance properties in hadron spectroscopy. The unbinned likelihood fits employed are however computationally very expensive especially in view of the very large data samples being collected at the Beijing Spectrometer (BES) III experiment and expected from future experiments such as Glue-X and PANDA. Using the power of massively parallel floating point calculations on graphics processing units (GPUs), we have managed to speed up PWA by more than two orders of magnitude compared to legacy implementations. The resulting software framework allows for the fast creation and running of PWA code. Modern hardware and software thus solve the PWA speed problems--many questions concerning fit methods and especially the reliability of fit results however remain open.

Berger, Niklaus

2011-10-01

277

Case Report and Dosimetric Analysis of an Axillary Recurrence After Partial Breast Irradiation with Mammosite Catheter  

SciTech Connect

Partial breast irradiation (PBI) was designed in part to decrease overall treatment times associated with whole breast radiation therapy (WBRT). WBRT treats the entire breast and usually portions of the axilla. The goal of PBI is to treat a smaller volume of breast tissue in less time, focusing the dose around the lumpectomy cavity. The following is a case of a 64-year-old woman with early-stage breast cancer treated with PBI who failed regionally in the ipsilateral axilla. With our dosimetric analysis, we found that the entire area of this axillary failure would have likely received at least 45 Gy if WBRT had been used, enough to sterilize microscopic disease. With PBI, this area received a mean dose of only 2.8 Gy, which raises the possibility that this regional failure may have been prevented had WBRT been used instead of PBI.

Shah, Anand P. [Department of Radiation Oncology, Department of Pathology, and Department of General Surgery, Rush University Medical Center, Chicago, IL (United States)], E-mail: anand_shah@rush.edu; Dickler, Adam; Kirk, Michael C.; Chen, Sea S.; Strauss, Jonathan B.; Coon, Alan B.; Turian, Julius V.; Siziopikou, Kalliopi; Dowlat, Kambiz; Griem, Katherine L. [Department of Radiation Oncology, Department of Pathology, and Department of General Surgery, Rush University Medical Center, Chicago, IL (United States)

2008-10-01

278

Diffractive imaging analysis of large-aperture segmented telescope based on partial Fourier transform  

NASA Astrophysics Data System (ADS)

Large-aperture segmented primary mirror will be widely used in next-generation space-based and ground-based telescopes. The effects of intersegment gaps, obstructions, position and figure errors of segments, which are all involved in the pupil plane, on the image quality metric should be analyzed using diffractive imaging theory. Traditional Fast Fourier Transform (FFT) method is very time-consuming and costs a lot of memory especially in dealing with large pupil-sampling matrix. A Partial Fourier Transform (PFT) method is first proposed to substantially speed up the computation and reduce memory usage for diffractive imaging analysis. Diffraction effects of a 6-meter segmented mirror including 18 hexagonal segments are simulated and analyzed using PFT method. The influence of intersegment gaps and position errors of segments on Strehl ratio is quantitatively analyzed by computing the Point Spread Function (PSF). By comparing simulation results with theoretical results, the correctness and feasibility of PFT method is confirmed.

Dong, Bing; Qin, Shun; Hu, Xinqi

2013-09-01

279

Thermodynamic analysis and conceptual design for partial coal gasification air preheating coal-fired combined cycle  

NASA Astrophysics Data System (ADS)

The partial coal gasification air pre-heating coal-fired combined cycle (PGACC) is a cleaning coal power system, which integrates the coal gasification technology, circulating fluidized bed technology, and combined cycle technology. It has high efficiency and simple construction, and is a new selection of the cleaning coal power systems. A thermodynamic analysis of the PGACC is carried out. The effects of coal gasifying rate, pre-heating air temperature, and coal gas temperature on the performances of the power system are studied. In order to repower the power plant rated 100 MW by using the PGACC, a conceptual design is suggested. The computational results show that the PGACC is feasible for modernizing the old steam power plants and building the new cleaning power plants.

Xu, Yue; Wu, Yining; Deng, Shimin; Wei, Shirang

2004-02-01

280

Partial wave analysis of J/{psi}{yields}pp{pi}{sup 0}  

SciTech Connect

Using a sample of 58 million J/{psi} events collected with the BESII detector at the BEPC, more than 100 000 J/{psi}{yields}pp{pi}{sup 0} events are selected, and a detailed partial wave analysis is performed. The branching fraction is determined to be Br(J/{psi}{yields}pp{pi}{sup 0})=(1.33{+-}0.02{+-}0.11)x10{sup -3}. A long-sought missing N*, first observed in J/{psi}{yields}pn{pi}{sup -}, is observed in this decay too, with mass and width of 2040{sub -4}{sup +3}{+-}25 MeV/c{sup 2} and 230{sub -8}{sup +8}{+-}52 MeV/c{sup 2}, respectively. Its spin-parity favors (3/2){sup +}. The masses, widths, and spin parities of other N* states are obtained as well.

Ablikim, M.; Bai, J. Z.; Bai, Y.; Cai, X.; Chen, H. S.; Chen, H. X.; Chen, J. C.; Chen, Jin; Chen, Y. B.; Chu, Y. P.; Deng, Z. Y.; Du, S. X.; Fang, J.; Fu, C. D.; Gao, C. S.; Gu, S. D.; Guo, Y. N.; He, K. L.; Heng, Y. K.; Hu, H. M. [Institute of High Energy Physics, Beijing 100049 (China)] (and others)

2009-09-01

281

Partial-wave analysis of coherent 3. pi. production on nuclei at 200 GeV  

SciTech Connect

We have carried out a partial-wave analysis (PWA) of three-pion systems produced in the coherent dissociation of ..pi../sup +/ mesons on nuclear targets. The data have been analyzed for copper and lead targets at an incident ..pi../sup +/ energy of 202.5 GeV. This PWA provides further evidence for resonant contributions to J/sup P/ = 1/sup +/ and 0/sup -/ waves at 3..pi.. masses below 1.5 GeV, which can be plausibly identified with A/sub 1/ and ..pi..' mesons. The contribution from electromagnetic production of the A/sub 2/ has also been extracted, and an estimate for Coulomb production and radiative width of the A/sub 1/ has been obtained.

Zielinski, M.; Berg, D.; Chandlee, C.; Cihangir, S.; Ferbel, T.; Huston, J.; Jensen, T.; Lobkowicz, F.; Ohshima, T.; Slattery, P.; Thompson, P.; Collick, B.; Heppelmann, S.; Marshak, M.; Peterson, E.; Ruddick, K.; Jonckheere, A.; Nelson C.A. Jr.

1984-11-01

282

Packaging Review Guide for Reviewing Safety Analysis Reports for Packagings  

SciTech Connect

This Packaging Review Guide (PRG) provides guidance for Department of Energy (DOE) review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE Order 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his or her review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. This PRG is generally organized at the section level in a format similar to that recommended in Regulatory Guide 7.9 (RG 7.9). One notable exception is the addition of Section 9 (Quality Assurance), which is not included as a separate chapter in RG 7.9. Within each section, this PRG addresses the technical and regulatory bases for the review, the manner in which the review is accomplished, and findings that are generally applicable for a package that meets the approval standards. This Packaging Review Guide (PRG) provides guidance for DOE review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE O 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. The primary objectives of this PRG are to: (1) Summarize the regulatory requirements for package approval; (2) Describe the technical review procedures by which DOE determines that these requirements have been satisfied; (3) Establish and maintain the quality and uniformity of reviews; (4) Define the base from which to evaluate proposed changes in scope and requirements of reviews; and (5) Provide the above information to DOE organizations, contractors, other government agencies, and interested members of the general public. This PRG was originally published in September 1987. Revision 1, issued in October 1988, added new review sections on quality assurance and penetrations through the containment boundary, along with a few other items. Revision 2 was published October 1999. Revision 3 of this PRG is a complete update, and supersedes Revision 2 in its entirety.

DiSabatino, A; Biswas, D; DeMicco, M; Fisher, L E; Hafner, R; Haslam, J; Mok, G; Patel, C; Russell, E

2007-04-12

283

Does partial root-zone drying improve irrigation water productivity in the field? A meta-analysis  

Microsoft Academic Search

Partial root-zone drying improves irrigation water productivity (IWP, yield per unit applied irrigation water) with respect\\u000a to controls receiving substantially more water, but similar gains are often achieved with conventional deficit irrigation.\\u000a This paper presents a meta-analysis of IWP for a broad range of horticultural crops and environments. Two comparisons were\\u000a preformed: (a) crops managed with either partial root-zone drying

V. O. Sadras

2009-01-01

284

Upgrade Uranium Recovery Project No. 34110: final safety analysis report  

SciTech Connect

The accident analysis of the upgrade uranium recovery system indicated three potential hazards: (1) criticality, (2) toxic fumes from nitric acid solutions, and (3) release of toxic uranyl nitrate solutions. Any of these are capable of causing the death of one or more employees; therefore, they form the basis for the residual risks identified below. The analysis found no hazardous energies or substances capable of causing irreversible injury to, or the death of, any members of the public. The following residual risks will be controlled administratively by procedural constraints: An operator or maintenance error will cause /sup 235/U to be transferred into an unsafe container and cause a criticality. An operator or maintenance error will cause containers of /sup 235/U bearing material to be improperly spaced and cause a criticality. Extensive corrosion will cause a hole to form in a calciner tube, the corrosion will go undetected, and a criticality will result, and a loss of system and/or building solution containment will occur concurrent with a drain being open resulting in a criticality and/or release of toxic material. Additional residual risks that have a small probability are that an earthquake or tornado will affect the building, alter the system geometry, and initiate a criticality; that the compressed-gas (nitrogen) cylinder valve will be sheared off, become airborne, and alter the system geometry; and that loss of system and/or building solution containment may occur concurrently with fire sprinkler system actuation causing a criticality and/or release of toxic material. The following residual risks will be addressed in the Safety Study of the existing X-705 Building: that a spill of raffinate highly contaminated with /sup 99/Tc will occur due to operator error or incorrect lab analysis and that a gaseous or liquid effluent release of small amounts of transuranic elements will occur.

Not Available

1981-09-01

285

Use and Interpretation of Confidence and Tolerance Intervals in Safety Analysis.  

National Technical Information Service (NTIS)

The statistical concepts of tolerance and confidence are reviewed, with particular reference to the presentation of quantitative probability based arguments as applied in safety analysis. The increasing difficulty in performing a meaningful analysis when ...

G. W. Parry P. Shaw D. H. Worledge

1977-01-01

286

Malliavin calculus and applications to sensitivity analysis of stochastic partial differential equations  

NASA Astrophysics Data System (ADS)

In this thesis, we apply Malliavin calculus to the sensitivity analysis of a stochastic partial differential equation of the Schrodinger type. The equation appears as the major building block in the analysis of the focusing properties of time-reversed waves in a random medium in the asymptotic regime where the parabolic approximation is valid. We consider the sensitivities of the solutions with respect to all sorts of parameters. Because of the imperfectness of the time reversal mirror, the time-reversed signal is an integral of a cut-off function. This makes Monte Carlo numerical schemes ineffecient for sensitivity analysis. Here Malliavin calculus comes to the rescue since it emerged out of the stochastic calculus of variations. With its "Integration by Parts" formula, we avoid computing the derivative of the cut-off function. Instead, we obtain close form formulae for the sensitivities in terms of Skorohod integrals with respect to an infinite dimensional Wiener process. We also construct finite dimensional approximation schemes for these integrals. These schemes are based on a sieve of Wiener chaos expansions mixed with Galerkin approximations in a natural Fourier basis. Numerical implementation is done in both 2-D and 3-D. To the best of our knowledge, the numerical computation of the stochastic Schrodinger equation's solution was only carried out in 2-D, and even in that case our numerical algorithm seems better than those we found in the literature.

Wang, Lixin

287

T-Hulls, Discretization, and Partially Ordered Sets in Molecular Shape Analysis  

NASA Astrophysics Data System (ADS)

T-Hulls are a generalization of Alpha-Hulls, where the reference to shape analysis is not a single curvature value, but the complete shape of a reference object T. Whereas T-Hulls provide a generalization of convexity theorems and are versatile tools for molecular shape analysis and shape analysis in general for objects in arbitrary dimensions, they are also tools for discretization of shape description as well as for transformations between continuous and discrete models with the aid of a single continuous parameter. This continuous parameter generates an ordering of shapes and if a finite number of such transformations are considered, for example, with reference to a combination of several molecular properties, then a partial ordering is obtained. This special property can be exploited in the molecular context if our goal is the establishment of rigorous connections between quantum chemical and discrete mathematical (such as graph theoretical) models used for molecular characterization in applied fields, such as QSAR or pharmaceutical drug design.

Mezey, Paul G.

2009-08-01

288

Cost–benefit analysis of road safety measures: applicability and controversies  

Microsoft Academic Search

This paper discusses the applicability of cost–benefit analysis as an aid to policy making for road safety measures. A framework for assessing the applicability of cost–benefit analysis is developed. Five main types of criticism of cost–benefit analysis are identified:1.rejecting the basic principles of cost–benefit analysis as not applicable to road safety,2.excluding some types of issues from the scope of calculation

Rune Elvik

2001-01-01

289

Development of a multichannel analysis code for the MITR-III safety analysis  

SciTech Connect

This paper describes the development of a MULti-CHannel analysis (MULCH-II) code to be used for the safety analysis of the Massachusetts Institute of Technology Research Reactor (MITR). The code models the primary and the secondary coolant systems with special emphasis on analysis of detailed thermal-hydraulic conditions in the core region. The hot channel is modeled in parallel with the average channels to predict conditions in the core during a flow excursion instability. Fuel and cladding temperatures are calculated under all conditions so that the margin to fuel failure is given in addition to the thermal-hydraulic conditions.

Hu, Lin-Wen; Bernard, J.A. [Massachusetts Inst. of Technology, Cambridge, MA (United States)

1996-12-31

290

Regional analysis of annual maximum and partial duration flood data by nonparametric and L-moment methods  

Microsoft Academic Search

The analysis of annual maximum (AM) flood series has revealed unimodal and multimodal probability density functions for floods in the Provinces of Ontario and Quebec, Canada. Based on density function shapes and the timing of floods, Ontario and Quebec have been divided into nine homogeneous regions reflecting similar flood generating mechanisms. A similar analysis of peak over threshold or partial

K. Adamowski

2000-01-01

291

Partial least-squares calibration diagnostics applied to the FT-IR analysis of borophosphosilicate glass (BPSG) thin films  

SciTech Connect

Full-spectrum multivariate calibration methods are capable of providing a multitude of diagnostic capabilities for evaluating the quality of the calibration, identifying problem calibration samples, and flagging unknown samples whose analysis by these methods might be unreliable. These diagnostics are demonstrated for the analysis of BPSG thin films on silicon using infrared spectroscopy and partial least-squares methods. 3 refs., 1 fig.

Haaland, D.M.

1989-01-01

292

Probabilistic safety analysis of a Greek Research Reactor  

Microsoft Academic Search

This paper presents the work and the results of a Level 1 Probabilistic Safety Assessment performed for the Greek Research Reactor of the National Center for Scientific Research “Demokritos”. Event trees have been used to study the response of the installation to various initiating events whereas fault trees have been used in the modelling of safety system failures. Using generic

O. N Aneziris; C Housiadas; M Stakakis; I. A Papazoglou

2004-01-01

293

The geography of patient safety: A topical analysis of sterility  

Microsoft Academic Search

Many studies on patient safety are geared towards prevention of adverse events by eliminating causes of error. In this article, I argue that patient safety research needs to widen its analytical scope and include causes of strength as well. This change of focus enables me to ask other questions, like why don't things go wrong more often? Or, what is

Jessica Mesman

2009-01-01

294

A comparative study of probabilistic structural safety analysis  

Microsoft Academic Search

Structural Safety is one of the most important factors of any aerospace product. Until recently, a design is considered to be robust if all the variables that affect its life has been accounted for and brought under control Safety factor cannot, by themselves, guarantee satisfactory performance and they do not provide sufficient information to achieve optimal use of available resources.

P. Bhattacharjee; K. Ramesh Kumar; T. A. Janardhan Reddy

2010-01-01

295

Safety culture evaluation and asset root cause analysis  

SciTech Connect

This paper examines the role of organizational and management factors in nuclear power plant safety through the use of operating experiences. The ASSET (Assessment of Safety Significant Events Team) reports of thirteen plants (total thirty events) have been analyzed in term of twenty organizational dimensions (factors) identified by Brookhaven National Laboratory and Pennsylvania State University. For three plants detailed results are reported in this paper. The results of thirteen plants are summarized in the form of a table. The study tends to confirm that organizational and management factors play an important role in plant safety. The twenty organizational dimensions and their definitions, in general, were adequate in this study. Formalization, Safety Culture, Technical Knowledge, Training, Roles-Responsibilities and Problem Identification appear to be key organizational factors which influence the safety of nuclear power plants studied.

Okrent, D.; Xiong, Y.

1995-12-31

296

Fast Flux Test Facility final safety analysis report. Amendment 72  

SciTech Connect

This document provides the Final Safety Analysis Report (FSAR) Amendment 72 for incorporation into the Fast Flux Test Facility (FFTF) FSAR set. This amendment change incorporates Engineering Change Notices issued subsequent to Amendment 71 and approved for incorporation before June 24, 1992. These include changes in: Chapter 2, Site Characteristics; Chapter 3, Design Criteria Structures, Equipment, and Systems; Chapter 5B, Reactor Coolant System; Chapter 7, Instrumentation and Control Systems; Chapter 8, Electrical Systems - The description of the Class 1E, 125 Vdc systems is updated for the higher capacity of the newly installed, replacement batteries; Chapter 9, Auxiliary Systems - The description of the inert cell NASA systems is corrected to list the correct number of spare sample points; Chapter 11, Reactor Refueling System; Chapter 12, Radiation Protection and Waste Management; Chapter 13, Conduct of Operations; Chapter 16, Quality Assurance; Chapter 17, Technical Specifications; Chapter 19, FFTF Fire Specifications for Fire Detection, Alarm, and Protection Systems; Chapter 20, FFTF Criticality Specifications; and Appendix B, Primary Piping Integrity Evaluation.

Gantt, D.A.

1992-08-01

297

Soft Mathematical Aggregation in Safety Assessment and Decision Analysis  

SciTech Connect

This paper improves on some of the limitations of conventional safety assessment and decision analysis methods. It develops a top-down mathematical method for expressing imprecise individual metrics as possibilistic or fuzzy numbers and shows how they may be combined (aggregated) into an overall metric, also portraying the inherent uncertainty. Both positively contributing and negatively contributing factors are included. Metrics are weighted according to significance of the attribute and evaluated as to contribution toward the attribute. Aggregation is performed using exponential combination of the metrics, since the accumulating effect of such factors responds less and less to additional factors. This is termed soft mathematical aggregation. Dependence among the contributing factors is accounted for by incorporating subjective metrics on overlap of the factors and by correspondingly reducing the overall contribution of these combinations to the overall aggregation. Decisions corresponding to the meaningfulness of the results are facilitated in several ways. First, the results are compared to a soft threshold provided by a sigmoid function. Second, information is provided on input ''Importance'' and ''Sensitivity,'' in order to know where to place emphasis on controls that may be necessary. Third, trends in inputs and outputs are tracked in order to add important information to the decision process. The methodology has been implemented in software.

Cooper, J. Arlin

1999-06-10

298

Partial Seizures  

MedlinePLUS

... are subdivided into simple partial seizures (in which consciousness or awareness is retained) and complex partial seizures (in which consciousness is impaired or lost). Partial seizures may spread ...

299

Idaho National Engineering Laboratory (INEL) Environmental Restoration (ER) Program Baseline Safety Analysis File (BSAF)  

SciTech Connect

The Baseline Safety Analysis File (BSAF) is a facility safety reference document for the Idaho National Engineering Laboratory (INEL) environmental restoration activities. The BSAF contains information and guidance for safety analysis documentation required by the U.S. Department of Energy (DOE) for environmental restoration (ER) activities, including: Characterization of potentially contaminated sites. Remedial investigations to identify and remedial actions to clean up existing and potential releases from inactive waste sites Decontamination and dismantlement of surplus facilities. The information is INEL-specific and is in the format required by DOE-EM-STD-3009-94, Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports. An author of safety analysis documentation need only write information concerning that activity and refer to BSAF for further information or copy applicable chapters and sections. The information and guidance provided are suitable for: {sm_bullet} Nuclear facilities (DOE Order 5480-23, Nuclear Safety Analysis Reports) with hazards that meet the Category 3 threshold (DOE-STD-1027-92, Hazard Categorization and Accident Analysis Techniques for Compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports) {sm_bullet} Radiological facilities (DOE-EM-STD-5502-94, Hazard Baseline Documentation) Nonnuclear facilities (DOE-EM-STD-5502-94) that are classified as {open_quotes}low{close_quotes} hazard facilities (DOE Order 5481.1B, Safety Analysis and Review System). Additionally, the BSAF could be used as an information source for Health and Safety Plans and for Safety Analysis Reports (SARs) for nuclear facilities with hazards equal to or greater than the Category 2 thresholds, or for nonnuclear facilities with {open_quotes}moderate{close_quotes} or {open_quotes}high{close_quotes} hazard classifications.

NONE

1995-09-01

300

Culture of Safety in Hospitals: A Three-Part Analysis of Safety Culture, Evidence-Based Practice Guidelines, and Patient Outcomes  

Microsoft Academic Search

Sammer, Christine E., Culture of Safety in Hospitals: A Three-Part Analysis of Safety Culture, Evidence-Based Practice Guidelines, and Patient Outcomes. Doctor of Public Health (Health Management and Policy), December 2009, 101 pp., 10 tables, 1 figure, references, 115 titles.\\u000aThis research is a three-part study of the culture of patient safety, evidence-based practice, and patient safety outcomes within the U.S.

Christine Sammer

2009-01-01

301

Finite Element Analysis of an Implant-Assisted Removable Partial Denture.  

PubMed

PURPOSE: This study analyzes the effects of loading a Kennedy class I implant-assisted removable partial denture (IARPD) using finite element analysis (FEA). Standard RPDs are not originally designed to accommodate a posterior implant load point. The null hypothesis is that the introduction of posteriorly placed implants into an RPD has no effect on the load distribution. MATERIALS AND METHODS: A Faro Arm scan was used to extract the geometrical data of a human partially edentulous mandible. A standard plus regular neck (4.8 × 12 mm) Straumann(®) implant and titanium matrix, tooth roots, and periodontal ligaments were modeled using a combination of reverse engineering in Rapidform XOR2 and solid modeling in Solidworks 2008 FEA program. The model incorporated an RPD and was loaded with a bilateral force of 120 N. ANSYS Workbench 11.0 was used to analyze deformation in the IARPD and elastic strain in the metal framework. RESULTS: FEA identified that the metal framework developed high strain patterns on the major and minor connectors, and the acrylic was subjected to deformation, which could lead to acrylic fractures. The ideal position of the neutral axis was calculated to be 0.75 mm above the ridge. CONCLUSION: A potentially destructive mismatch of strain distribution was identified between the acrylic and metal framework, which could be a factor in the failure of the acrylic. The metal framework showed high strain patterns on the major and minor connectors around the teeth, while the implant components transferred the load directly to the acrylic. PMID:23551664

Shahmiri, Reza; Aarts, John M; Bennani, Vincent; Atieh, Momen A; Swain, Michael V

2013-04-01

302

Partial sequence analysis of B2L gene of Brazilian orf viruses from sheep and goats.  

PubMed

We herein describe the partial nucleotide sequencing and phylogenetic analysis of the B2L gene of seventeen Brazilian orf viruses (ORFV). Seventeen viruses were recovered from outbreaks of contagious ecthyma in sheep and goats in four states in Southern and Northeast country, and three from commercial vaccines. Most analyzed viruses were associated with outbreaks of classical contagious ecthyma, with lip, nostrils and labial commissure involvement, yet udder/teat, feet, vulvar and disseminated lesions were also reported in some cases. Nucleotide sequence analysis revealed a high degree of B2L similarity among sheep sequences (>99%) regardless the geographic origin, and a remarkable high identity for the two goat isolates (>99.8%), with similarity dropping to below 99% when comparing viruses from the two species. A phylogenetic tree grouped most sheep and goat viruses on different branches. In addition, sequence alignment allowed the identification of up to six scattered nucleotide changes that were predominant and more consistent in goat isolates, including a number of sequences from other continents. Thus, in spite of the high nucleotide similarity, different degrees of similarity and discrete nucleotide changes in the B2L gene may help in grouping ORFV viruses according to host species. PMID:23200438

Schmidt, Candice; Cargnelutti, Juliana F; Brum, Mário C S; Traesel, Carolina K; Weiblen, Rudi; Flores, Eduardo F

2012-11-08

303

QSAR and QSPR model interpretation using partial least squares (PLS) analysis.  

PubMed

Carefully developed quantitative structure-activity and structure-property relationship models contain detailed information regarding how differences in the molecular structure of compounds correlate with differences in the observed biological or other physicochemical properties of those compounds. The ability to understand the behavior of existing molecules and to design new molecules is facilitated by using an objective method to extract and explain the details of the underlying structure-activity or structure-property relationship. Furthermore, a clear understanding of how and why compounds behave as they do can lead to new innovations through model-directed selection of compounds to be used in complex mixtures such as laundry detergents, fabric softeners, and shampoos. Such a method has been developed based on partial least-squares (PLS) regression analysis that allows for the identification of specific structural trends that relate to differences in observed properties. But the analysis of the completed model is only the last step of the process. The model development process itself affects the ability to extract a clear interpretation of the model. Everything from the selection of initial pool of molecular descriptors to evaluate to data set and model optimization impacts the ability to derive detailed molecular design information. This review describes the method details and examples of the use of PLS for model interpretation and also outlines suggestions regarding model development and model and data set optimization that enable the interpretation process. PMID:22497466

Stanton, David T

2012-06-01

304

Complete Versus Partial Fundoplication in Children with Gastroesophageal Reflux Disease: Results of a Systematic Review and Meta-analysis.  

PubMed

Complete fundoplication (Nissen) has long been accepted as the gold standard surgical procedure in children with therapy-resistant gastroesophageal reflux disease (GERD); however, increasingly more evidence has become available for partial fundoplication as an alternative. The aim of this study was to perform a systematic review and meta-analysis comparing complete versus partial fundoplication in children with therapy-resistant GERD. PubMed (1960 to 2011), EMBASE (from 1980 to 2011), and the Cochrane Library (issue 3, 2011) were systematically searched according to the PRISMA statement. Results were pooled in meta-analyses and expressed as risk ratios (RRs). In total, eight original trials comparing complete to partial fundoplication were identified. Seven of these studies had a retrospective study design. Short-term (RR 0.64; p?=?0.28) and long-term (RR 0.85; p?=?0.42) postoperative reflux control was similar for complete and partial fundoplication. Complete fundoplication required significantly more endoscopic dilatations for severe dysphagia (RR 7.26; p?=?0.007) than partial fundoplication. This systematic review and meta-analysis showed that reflux control is similar after both complete and partial fundoplication, while partial fundoplication significantly reduces the number of dilatations to treat severe dysphagia. However, because of the lack of a well-designed study, we have to be cautious in making definitive conclusions. To decide which type of fundoplication is the best practice in pediatric GERD patients, more randomized controlled trials comparing complete to partial fundoplication in children with GERD are warranted. PMID:23943388

Mauritz, F A; Blomberg, B A; Stellato, R K; van der Zee, D C; Siersema, P D; van Herwaarden-Lindeboom, M Y A

2013-08-14

305

Review of design criteria and safety analysis of safety class electric building for fuel test loop.  

National Technical Information Service (NTIS)

Steady state fuel test loop will be equipped in HANARO to obtain the development and betterment of advanced fuel and materials through the irradiation tests. HANARO fuel test loop was designed for CANDU and PWR fuel testing. Safety related system of Fuel ...

J. Kim

1998-01-01

306

Statistical Model for Range Safety Analysis of Laser Hazard. Revised.  

National Technical Information Service (NTIS)

A statistical model of a laser designator pulse train is developed. The model is applicable to the quantification of range safety hazards associated with field tests of tactical weapons which employ lasers. Numerical results of selected test cases are giv...

1982-01-01

307

Reliability Analysis of DSRC Wireless Communication for Vehicle Safety Applications  

Microsoft Academic Search

The 802.11-p based dedicated short range communication (DSRC) is being seriously considered as a promising wireless technology for enhancing transportation safety and highway efficiency. However, to-date, there is very little research done in characterizing the reliability of DSRC communication based on real-world experimental data, and its effect on the reliability of vehicle safety applications. Our experimental set-up includes a fleet

Fan Bai; Hariharan Krishnan

2006-01-01

308

A ''Toolbox''21 Equivalent Process for Safety Analysis Software  

Microsoft Academic Search

Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 2002-1 (Quality Assurance for Safety-Related Software) identified a number of quality assurance issues on the use of software in Department of Energy (DOE) facilities for analyzing hazards, and designing and operating controls that prevent or mitigate potential accidents. The development and maintenance of a collection, or ''toolbox,'' of multiple-site use, standard solution, Software

2004-01-01

309

Analysis of adhesion and interface debonding in laminated safety glass  

Microsoft Academic Search

Abstraet-A tension adhesion test is developed and analyzed to characterize polymer\\/glass adhesion in laminated safety glass. Laminated safety glass typically consists of two sheets of glass bonded by a polymer adhesive interlayer, usually plasticized poly(vinyl butyral). In the tension test, a rectangular laminate specimen is cracked on both glass sides, and loaded under a remote tension P at a constant

Y. Sha; C. Y. Hui; E. J. Kramer; P. D. Garrett; J. W. Knapczyk

1997-01-01

310

Markov Modeling with Soft Aggregation for Safety and Decision Analysis  

SciTech Connect

The methodology in this report improves on some of the limitations of many conventional safety assessment and decision analysis methods. A top-down mathematical approach is developed for decomposing systems and for expressing imprecise individual metrics as possibilistic or fuzzy numbers. A ''Markov-like'' model is developed that facilitates combining (aggregating) inputs into overall metrics and decision aids, also portraying the inherent uncertainty. A major goal of Markov modeling is to help convey the top-down system perspective. One of the constituent methodologies allows metrics to be weighted according to significance of the attribute and aggregated nonlinearly as to contribution. This aggregation is performed using exponential combination of the metrics, since the accumulating effect of such factors responds less and less to additional factors. This is termed ''soft'' mathematical aggregation. Dependence among the contributing factors is accounted for by incorporating subjective metrics on ''overlap'' of the factors as well as by correspondingly reducing the overall contribution of these combinations to the overall aggregation. Decisions corresponding to the meaningfulness of the results are facilitated in several ways. First, the results are compared to a soft threshold provided by a sigmoid function. Second, information is provided on input ''Importance'' and ''Sensitivity,'' in order to know where to place emphasis on considering new controls that may be necessary. Third, trends in inputs and outputs are tracked in order to obtain significant information% including cyclic information for the decision process. A practical example from the air transportation industry is used to demonstrate application of the methodology. Illustrations are given for developing a structure (along with recommended inputs and weights) for air transportation oversight at three different levels, for developing and using cycle information, for developing Importance and Sensitivity measures for soil aggregation, for developing dependence methodology, for constructing early alert logic, for tracking trends, for relating the Markov model to other (e.g., Reason) models, for developing and demonstrating rudimentary laptop software, and for developing an input/output display methodology.

COOPER,J. ARLIN

1999-09-01

311

Dose as Instrumental Variable in Exposure–Safety Analysis Using Count Models  

Microsoft Academic Search

Confounding bias often occurs in the analysis of the exposure–safety relationship due to confounding factors that have impacts on both drug exposure and safety outcomes. Instrumental variable (IV) methods have been widely used to eliminate or to reduce the bias in observational studies in, for example, epidemiology. Recently applications of IV methods can also be found in clinical trials to

Jixian Wang

2012-01-01

312

SAFETY ANALYSIS AND INTEGRATION FOR ROBOTIC SYSTEMS - APPLICATION TO A MEDICAL ROBOT FOR TELE-ECHOGRAPHY  

Microsoft Academic Search

Today, as many new application areas for robotic systems emerge, safety is be- coming critical. Indeed, service robots, including medical robots, share their working area or have a close interaction with humans. This paper presents a deductive method for safety anal- ysis and integration. This method uses well-known analysis techniques for computer control systems and includes the use of a

J. GUIOCHET; B. TONDU; C. BARON

2001-01-01

313

Safety Analysis of Fuel Circulating System for Tokamak Experimental Fusion Reactor.  

National Technical Information Service (NTIS)

Design study and safety analysis on the fuel circulating system (FCS) for a Tokamak experimental fusion reactor have been carried out, in tritium containment and safety. A three-stage containment system of tritium fuel is settled to control tritium releas...

1978-01-01

314

Preliminary Safety Analysis Report and Design Review of the 2 KW(e) Radioisotope Thermoelectric Generator.  

National Technical Information Service (NTIS)

A Preliminary Safety Analysis Report (PSAR) and Design Review have been conducted for the 2 KW(e) Radioisotope Thermoelectric Generator (RTG). The objective of the PSAR was to appraise the risk to public health and safety resulting from the handling, tran...

1975-01-01

315

Food safety, Hazard Analysis and Critical Control Point and the increase in foodborne diseases: a paradox?  

Microsoft Academic Search

The application of the Hazard Analysis and Critical Control Point (HACCP) system is rapidly progressing, in particular in large and medium scale food industries. The term is becoming well known in food control and public health circles and is one which evokes food safety. However, concomitant with the headway of the HACCP system in food safety management, the incidence of

Yasmine Motarjemi; Fritz Käferstein

1999-01-01

316

Safety-Guided Design through System-Theoretic Process Analysis, Benefits and Difficulties  

Microsoft Academic Search

Development environments for embedded systems are moving towards increased automation between Commercial Of The Shelf (COTS) engineering tools. While automation provides new opportunities for e.g. verification, it also to some extent decreases the possibility of identifying and acting on safety issues that arise during development. To investigate the relationship between tool integration and safety we performed a System-Theoretic Process Analysis

M. S. Fredrik Asplund; D. Jad El-khoury; Martin Törngren

317

Development of safety analysis and constraint detection techniques for process interaction errors  

Microsoft Academic Search

Among the new failure modes introduced by computer into safety systems, the process interaction error is the most unpredictable and complicated failure mode, which may cause disastrous consequences. This paper presents safety analysis and constraint detection techniques for process interaction errors among hardware, software, and human processes. Among interaction errors, the most dreadful ones are those that involve run-time misinterpretation

Chin-Feng Fan; Shang-Lin Tsai; Wan-Hui Tseng

2011-01-01

318

Proposed outline of safety analysis report for facilities for geologic isolation of radioactive wastes  

Microsoft Academic Search

This report is concerned with formulating the appropriate and necessary contents for a Safety Analysis Report (SAR) for safe, long-term radioactive waste isolation in federal repositories. The material is presented as a guide rather than as an outline of a SAR. Site characteristics, design criteria, facility design, operational systems and components, radiation protection and operational safety, long-term waste isolation, conduct

L. W. Weisbecker; L. L. Gerchman; B. R. Holt; S. J. Mara; S. L. McHugh; H. M. Taylor; J. E. Van Zandt; D. R. Zoellner

1977-01-01

319

Safety analysis of IFR fuel processing in the Argonne National Laboratory Fuel Cycle Facility  

Microsoft Academic Search

The Integral Fast Reactor (IFR) concept developed by Argonne National Laboratory (ANL) includes on-site processing and recycling of discharged core and blanket fuel materials. The process is being demonstrated in the Fuel Cycle Facility (FCF) at ANL`s Idaho site. This paper describes the safety analyses that were performed in support of the FCF program; the resulting safety analysis report was

I Charak; D. R. Pedersen; R. J. Forrester; R. D. Phipps

1993-01-01

320

Disadvantage of modal analysis for safety assessment shown by vibration examples in concrete structures  

Microsoft Academic Search

System safety assessment in Structural Health Monitoring (SHM) systems can prevent structural failure of safety- critical structures both in mechanic engineering and civil engineering. As a linear method, modal analysis has been applied extensively in SHM systems. However, it is not reliable for civil engineering application due to the unique damage mechanism in concrete structures. This paper shows major disadvantages

Zihua Zhang; Guahua Liu; Zhigen Wu

2011-01-01

321

Utilization of the MCNP-3A code for criticality safety analysis  

SciTech Connect

In the last decade, Brazil started to operate facilities for processing and storing uranium in different forms. The necessity of criticality safety analysis appeared in the design phase of the uranium pilot process plants and also in the licensing of transportation and storage of fissile materials. The 2-MW research reactor and the Angra I power plant also required criticality safety assessments because their spent-fuel storage was approaching full-capacity utilization. The criticality safety analysis in Brazil has been based on KENO IV code calculations, which present some difficulties for correct geometry representation. The MCNP-3A code is not reported to be used frequently for criticality safety analysis in Brazil, but its good geometry representation makes it a possible tool for treating problems of complex geometry. A set of benchmark tests was performed to verify its applicability for criticality safety analysis in Brazil. This paper presents several benchmark tests aimed at selecting a set of options available in the MCNP-3A code that would be adequate for criticality safety analysis. The MCNP-3A code is also compared with the KENO-IV code regarding its performance for criticality safety analysis.

Maragni, M.G.; Moreira, J.M.L. [Centro Tecnologico da Marinha em S. Paulo (Brazil)

1996-12-31

322

Maximal Sharing of Partial Terms in Multiple Constant Multiplications: Analysis of an Exact Algorithm  

Microsoft Academic Search

ó In this paper1 we propose an exact algorithm that maximizes the sharing of partial terms in Multiple Constant Multiplication (MCM) operations. We model this problem as a Boolean network that covers all possible partial terms which may be used to generate the set of coefcients in the MCM instance. The PIs to this network are shifted versions of the

Paulo Flores; Eduardo Costa

323

Learning to Work in Partially Distributed Teams: An Analysis of Emergent Communication Structures and Technology Appropriation  

Microsoft Academic Search

A partially distributed team is a virtual team, in which two or more co-located subteams use communication technology to collaborate across distance. Due to factors such as globalization and mergers, an increasing number of IT projects are conducted in partially distributed teams (PDTs). However, students lack experience in how to work effectively in such situations. This field study involved more

Rosalie J. Ocker; Heidi C. Webb; Starr Roxanne Hiltz; Ian D. Brown

2010-01-01

324

High frequency finite element analysis of electromagnetic radiation due to partial discharges in high voltage equipment  

Microsoft Academic Search

Measuring partial discharge (PD) activity in high voltage plant is a well established technique used to monitor insulation integrity. A partial discharge is a surge of electrons within a dielectric due to ionisation caused by the electric field and it is a sign of insulation degradation or overstressing. The acceleration of electrons creates electromagnetic radiation. This paper studies the high

S. Xiao; P. J. Moore; M. D. Judd; I. E. Portugues

2008-01-01

325

Behavioral Assessment, Analysis, and Support in a Psychiatric Partial Hospitalization Program for Adults with Developmental Disabilities  

Microsoft Academic Search

This article describes the objectives and operations of a behavioral psychology service within a partial hospitalization program for adults with psychiatric disorders and developmental disabilities. Partial hospitalization programs are an effective model of psychiatric service delivery but are not common for patients with mental retardation\\/mental illness. Phases of intake behavioral assessment, treatment planning and implementation, and discharge are described with

James K. Luiselli; Kathleen Lisowski; Robin Weiss

1998-01-01

326

Radioisotopic neutron transmission spectrometry: Quantitative analysis by using partial least-squares method.  

PubMed

Neutron spectrometry, based on the scattering of high energy fast neutrons from a radioisotope and slowing-down by the light hydrogen atoms, is a useful technique for non-destructive, quantitative measurement of hydrogen content because it has a large measuring volume, and is not affected by temperature, pressure, pH value and color. The most common choice for radioisotope neutron source is (252)Cf or (241)Am-Be. In this study, (252)Cf with a neutron flux of 6.3x10(6)n/s has been used as an attractive neutron source because of its high flux neutron and weak radioactivity. Pulse-height neutron spectra have been obtained by using in-house built radioisotopic neutron spectrometric system equipped with (3)He detector and multi-channel analyzer, including a neutron shield. As a preliminary study, polyethylene block (density of approximately 0.947g/cc and area of 40cmx25cm) was used for the determination of hydrogen content by using multivariate calibration models, depending on the thickness of the block. Compared with the results obtained from a simple linear calibration model, partial least-squares regression (PLSR) method offered a better performance in a quantitative data analysis. It also revealed that the PLSR method in a neutron spectrometric system can be promising in the real-time, online monitoring of the powder process to determine the content of any type of molecules containing hydrogen nuclei. PMID:19285419

Kim, Jong-Yun; Choi, Yong Suk; Park, Yong Joon; Jung, Sung-Hee

2009-02-20

327

Continuous wavelet transform based partial least squares regression for quantitative analysis of Raman spectrum.  

PubMed

Quantitative analysis of Raman spectra using surface-enhanced Raman scattering (SERS) nanoparticles has shown the potential and promising trend of development in in vivo molecular imaging. Partial least square regression (PLSR) methods have been reported as state-of-the-art methods. However, the approaches fully rely on the intensities of Raman spectra and can not avoid the influences of the unstable background. In this paper we design a new continuous wavelet transform based PLSR (CWT-PLSR) algorithm that uses mixing concentrations and the average CWT coefficients of Raman spectra to carry out PLSR. We elaborate and prove how the average CWT coefficients with a Mexican hat mother wavelet are robust representations of Raman peaks, and the method can reduce the influences of unstable baseline and random noises during the prediction process. The algorithm was tested using three Raman spectra data sets with three cross-validation methods in comparison with current leading methods, and the results show its robustness and effectiveness. PMID:23963247

Li, Shuo; Nyagilo, James O; Dave, Digant P; Gao, Jean X

2013-08-15

328

Morphological segmentation and partial volume analysis for volumetry of solid pulmonary lesions in thoracic CT scans.  

PubMed

Volumetric growth assessment of pulmonary lesions is crucial to both lung cancer screening and oncological therapy monitoring. While several methods for small pulmonary nodules have previously been presented, the segmentation of larger tumors that appear frequently in oncological patients and are more likely to be complexly interconnected with lung morphology has not yet received much attention. We present a fast, automated segmentation method that is based on morphological processing and is suitable for both small and large lesions. In addition, the proposed approach addresses clinical challenges to volume assessment such as variations in imaging protocol or inspiration state by introducing a method of segmentation-based partial volume analysis (SPVA) that follows on the segmentation procedure. Accuracy and reproducibility studies were performed to evaluate the new algorithms. In vivo interobserver and interscan studies on low-dose data from eight clinical metastasis patients revealed that clinically significant volume change can be detected reliably and with negligible computation time by the presented methods. In addition, phantom studies were conducted. Based on the segmentation performed with the proposed method, the performance of the SPVA volumetry method was compared with the conventional technique on a phantom that was scanned with different dosages and reconstructed with varying parameters. Both systematic and absolute errors were shown to be reduced substantially by the SPVA method. The method was especially successful in accounting for slice thickness and reconstruction kernel variations, where the median error was more than halved in comparison to the conventional approach. PMID:16608058

Kuhnigk, Jan-Martin; Dicken, Volker; Bornemann, Lars; Bakai, Annemarie; Wormanns, Dag; Krass, Stefan; Peitgen, Heinz-Otto

2006-04-01

329

Hydrogen Safety Project chemical analysis support task: Window C'' volatile organic analysis  

SciTech Connect

This data package contains the results obtained by Pacific Northwest Laboratory (PNL) staff in the characterization of samples for the 101-SY Hydrogen Safety Project. The samples were submitted for analysis by Westinghouse Hanford Company (WHC) under the Technical Project Plan (TPP) 17667 and the Quality Assurance Plan MCS-027. They came from a core taken during Window C'' after the May 1991 gas release event. The analytical procedures required for analysis were defined in the Test Instructions (TI) prepared by the PNL 101-SY Analytical Chemistry Laboratory (ACL) Project Management Office in accordance with the TPP and the QA Plan. The requested analysis for these samples was volatile organic analysis. The quality control (QC) requirements for each sample are defined in the Test Instructions for each sample. The QC requirements outlined in the procedures and requested in the WHC statement of work were followed.

Gillespie, B.M.; Stromatt, R.W.; Ross, G.A.; Hoope, E.A.

1992-01-01

330

Hydrogen Safety Project chemical analysis support task: Window ``C`` volatile organic analysis  

SciTech Connect

This data package contains the results obtained by Pacific Northwest Laboratory (PNL) staff in the characterization of samples for the 101-SY Hydrogen Safety Project. The samples were submitted for analysis by Westinghouse Hanford Company (WHC) under the Technical Project Plan (TPP) 17667 and the Quality Assurance Plan MCS-027. They came from a core taken during Window ``C`` after the May 1991 gas release event. The analytical procedures required for analysis were defined in the Test Instructions (TI) prepared by the PNL 101-SY Analytical Chemistry Laboratory (ACL) Project Management Office in accordance with the TPP and the QA Plan. The requested analysis for these samples was volatile organic analysis. The quality control (QC) requirements for each sample are defined in the Test Instructions for each sample. The QC requirements outlined in the procedures and requested in the WHC statement of work were followed.

Gillespie, B.M.; Stromatt, R.W.; Ross, G.A.; Hoope, E.A.

1992-01-01

331

Insights into partial melting processes through integrated isotopic and trace element analysis of zircon (Invited)  

NASA Astrophysics Data System (ADS)

The utility of zircon, through it’s resilience during recycling in magmatic and detrital environments and to the ravages of high-T metamorphism and melting, has made this mineral our most popular chronometer. However, the sensitivity of zircon to record conditions of growth has taken it from pure chronometer to a multi-faceted geochemical fingerprint device that provides time-stamped snapshots of many geological processes. For example, the partitioning of the rare earth and other trace elements into zircon can record the relative formation of zircon with respect to key mineral assemblages in metamorphic rocks and melts. When integrated with other isotopic data such as O, Hf and U-Pb, these data provide powerful insights into the processes operating deep in the continental crust. Rare earth element (REE) analysis of zircon and garnet grown during high-grade metamorphism and anatexis has shown that the compositions of these minerals are sensitive to the timing of mineral growth relative to melt evolution, and to the compositions of source rocks from which melts are derived. Zircon-garnet REE distribution behavior has successfully been used to pin-point the location and relative timing of zircon growth in migmatites, allowing us not only to date partial melting, but also to assess the effects of melt generation, migration, drainage and recharge in migmatites within the deep crust. Integration of oxygen isotope analysis of zircon and garnet provides a new angle to investigate further the origin of zircon grains within a melt system and to assess our interpretations made on zircon-garnet equilibrium from REE data. For example, recent studies indicate that garnet oxygen isotope compositions are sensitive to changing conditions during metamorphism and the onset of partial melting, and integrated oxygen isotope studies of zircon with garnet have shown their utility to trace the sources of crystallized melts within migmatites. We present preliminary results from ion microprobe oxygen isotope analysis of zircon and garnet from metapelitic migmatites, in which the REE distribution behavior have been well established. Results indicate that for samples where zircon and garnet were interpreted to have formed in equilibrium on the basis of REE data, these minerals were in or close to oxygen isotope equilibrium. Samples in which zircon and garnet are in clear REE disequilibrium, oxygen isotope disequilibrium was also apparent. In the latter case, results further suggest that the REE-depleted garnet grew from a melt more primitive than zircon in the same rock. Preliminary results suggest good apparent agreement between oxygen isotope and REE data. However, oxygen isotope data alone do not unambiguously determine the relative timing of zircon and garnet growth, but only whether they grew from a melt of the same oxygen isotope composition. As such, integrated analysis of multiple trace element and isotopic tracers are recommended to fully understand the complexities recorded by zircon in migmatitic systems. Ultimately, such integrated studies have the potential to provide valuable insights into the timing of melt generation and duration of melt-present conditions relative to deformation during orogenesis.

Kelly, N. M.; Harley, S. L.; Appleby, S. K.; Matthews, J. A.

2010-12-01

332

Partial sequencing of the bottle gourd genome reveals markers useful for phylogenetic analysis and breeding  

PubMed Central

Background Bottle gourd [Lagenaria siceraria (Mol.) Standl.] is an important cucurbit crop worldwide. Archaeological research indicates that bottle gourd was domesticated more than 10,000 years ago, making it one of the earliest plants cultivated by man. In spite of its widespread importance and long history of cultivation almost nothing has been known about the genome of this species thus far. Results We report here the partial sequencing of bottle gourd genome using the 454 GS-FLX Titanium sequencing platform. A total of 150,253 sequence reads, which were assembled into 3,994 contigs and 82,522 singletons were generated. The total length of the non-redundant singletons/assemblies is 32 Mb, theoretically covering ~ 10% of the bottle gourd genome. Functional annotation of the sequences revealed a broad range of functional types, covering all the three top-level ontologies. Comparison of the gene sequences between bottle gourd and the model cucurbit cucumber (Cucumis sativus) revealed a 90% sequence similarity on average. Using the sequence information, 4395 microsatellite-containing sequences were identified and 400 SSR markers were developed, of which 94% amplified bands of anticipated sizes. Transferability of these markers to four other cucurbit species showed obvious decline with increasing phylogenetic distance. From analyzing polymorphisms of a subset of 14 SSR markers assayed on 44 representative China bottle gourd varieties/landraces, a principal coordinates (PCo) analysis output and a UPGMA-based dendrogram were constructed. Bottle gourd accessions tended to group by fruit shape rather than geographic origin, although in certain subclades the lines from the same or close origin did tend to cluster. Conclusions This work provides an initial basis for genome characterization, gene isolation and comparative genomics analysis in bottle gourd. The SSR markers developed would facilitate marker assisted breeding schemes for efficient introduction of desired traits.

2011-01-01

333

Macroergonomic analysis and design for improved safety and quality performance.  

PubMed

Macroergonomics, which emerged historically after sociotechnical systems theory, quality management, and ergonomics, is presented as the basis for a needed integrative methodology. A macroergonomics methodology was presented in some detail to demonstrate how aspects of microergonomics, total quality management (TQM), and sociotechnical systems (STS) can be triangulated in a common approach. In the context of this methodology, quality and safety were presented as 2 of several important performance criteria. To demonstrate aspects of the methodology, 2 case studies were summarized with safety and quality performance results where available. The first case manipulated both personnel and technical factors to achieve a "safety culture" at a nuclear site. The concept of safety culture is defined in INSAG-4 (International Atomic Energy Agency, 1991). as "that assembly of characteristics and attitudes in organizations and individuals which establishes that, as an overriding priority, nuclear plant safety issues receive the attention warranted by their significance." The second case described a tire manufacturing intervention to improve quality (as defined by Sink and Tuttle, 1989) through joint consideration of technical and social factors. It was suggested that macroergonomics can yield greater performance than can be achieved through ergonomic intervention alone. Whereas case studies help to make the case, more rigorous formative and summative research is needed to refine and validate the proposed methodology respectively. PMID:10602647

Kleiner, B M

1999-01-01

334

Predictors of Local Recurrence Following Accelerated Partial Breast Irradiation: A Pooled Analysis  

SciTech Connect

Purpose: To analyze a pooled set of nearly 2,000 patients treated on the American Society of Breast Surgeons (ASBS) Mammosite Registry Trial and at William Beaumont Hospital (WBH) to identify factors associated with local recurrence following accelerated partial breast irradiation (APBI). Methods and Materials: A total of 1,961 women underwent partial breast irradiation between April 1993 and November 2010 as part of the ASBS Registry Trial or at WBH. Rates of ipsilateral breast tumor recurrence (IBTR), regional recurrence (RR), distant metastases (DM), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS) were analyzed for each group and for the pooled cohort. Clinical, pathologic, and treatment-related variables were analyzed including age, tumor stage/size, estrogen receptor status, surgical margins, and lymph node status to determine their association with IBTR. Results: The two groups weres similar, but WBH patients were more frequently node positive, had positive margins, and were less likely to be within the American Society for Radiation Oncology-unsuitable group. At 5 years, the rates of IBTR, RR, DM, DFS, CSS, and OS for the pooled group of patients were 2.9%, 0.5%, 2.4%, 89.1%, 98.5%, and 91.8%, respectively. The 5-year rate of true recurrence/marginal miss was 0.8%. Univariate analysis of IBTR found that negative estrogen receptor status (odds ratio [OR], 2.83, 95% confidence interval 1.55-5.13, p = 0.0007) was the only factor significantly associated with IBTR, while a trend was seen for age less than 50 (OR 1.80, 95% confidence interval 0.90-3.58, p = 0.10). Conclusions: Excellent 5-year outcomes were seen following APBI in over 1,900 patients. Estrogen receptor negativity was the only factor associated with IBTR, while a trend for age less than 50 was noted. Significant differences in factors associated with IBTR were noted between cohorts, suggesting that factors driving IBTR may be predicated based on the risk stratification of the patients being treated.

Shah, Chirag; Wilkinson, John Ben [Department of Radiation Oncology, Beaumont Cancer Institute, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Lyden, Maureen [Biostat Inc., Tampa, Florida (United States); Beitsch, Peter [Dallas Breast Center, Dallas, Texas (United States); Vicini, Frank A., E-mail: fvicini@pol.net [Department of Radiation Oncology, Beaumont Cancer Institute, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States)

2012-04-01

335

Use of Fault Tree Analysis for Automotive Reliability and Safety Analysis  

SciTech Connect

Fault tree analysis (FTA) evolved from the aerospace industry in the 1960's. A fault tree is deductive logic model that is generated with a top undesired event in mind. FTA answers the question, ''how can something occur?'' as opposed to failure modes and effects analysis (FMEA) that is inductive and answers the question, ''what if?'' FTA is used in risk, reliability and safety assessments. FTA is currently being used by several industries such as nuclear power and chemical processing. Typically the automotive industries uses failure modes and effects analysis (FMEA) such as design FMEAs and process FMEAs. The use of FTA has spread to the automotive industry. This paper discusses the use of FTA for automotive applications. With the addition automotive electronics for various applications in systems such as engine/power control, cruise control and braking/traction, FTA is well suited to address failure modes within these systems. FTA can determine the importance of these failure modes from various perspectives such as cost, reliability and safety. A fault tree analysis of a car starting system is presented as an example.

Lambert, H

2003-09-24

336

Transient feature extraction based on phase space fusion by partial-least-square regression analysis of sensor array signals  

Microsoft Academic Search

Pattern classification based on transient signal analysis provides an effective method for identification of dynamical systems. The partial-least-square regression (PLSR) is most commonly used to generate parametric representation of phase space defined by measured signals and their time derivatives. The PLS component scores are interpreted as object features for pattern identification. In this paper, we consider sensor array transients, and

Prashant Singh; R. D. S. Yadava

2011-01-01

337

System safety and hazard analysis for the Advanced Technology Solar Telescope  

NASA Astrophysics Data System (ADS)

The Advanced Technology Solar Telescope (ATST) is a four-meter class instrument being built to perform diffractionlimited observations of the sun. This paper describes how ATST has dealt with system safety and in particular hazard analysis during the design and development (D&D) phase. For ATST the development of a system safety plan and the oversight of the hazard analysis fell, appropriately, to systems engineering. We have adopted the methodology described in MIL-STD-882E, "Standard Practice for System Safety." While these methods were developed for use by the U.S. Department of Defense, they are readily applicable to the safety needs of telescope projects. We describe the details of our process, how it was implemented by the ATST design team, and some useful lessons learned. We conclude with a discussion of our safety related plans during the construction phase of ATST and beyond.

Hubbard, Robert P.

2010-07-01

338

Safety Analysis Report: X17B2 beamline Synchrotron Medical Research Facility  

SciTech Connect

This report contains a safety analysis for the X17B2 beamline synchrotron medical research facility. Health hazards, risk assessment and building systems are discussed. Reference is made to transvenous coronary angiography. (LSP)

Gmuer, N.F.; Thomlinson, W.

1990-02-01

339

Fire Safety of Passenger Trains; Phase II: Application of Fire Hazard Analysis Techniques.  

National Technical Information Service (NTIS)

A comprehensive multi-phase fire safety research program is being conducted by the National Institute of Standards and Technology to demonstrate the practicality and effectiveness of heat release rate-based test methods and hazard analysis techniques when...

R. D. Peacock P. A. Reneke J. D. Averill R. W. Bukowski J. H. Klote

2002-01-01

340

Methodology Assessment and Recommendations for the Mars Science Laboratory Launch Safety Analysis.  

National Technical Information Service (NTIS)

The Department of Energy has assigned to Sandia National Laboratories the responsibility of producing a Safety Analysis Report (SAR) for the plutonium-dioxide fueled Multi-Mission Radioisotope Thermoelectric Generator (MMRTG) proposed to be used in the Ma...

B. R. Sturgis B. W. Dodson C. D. Atcitty D. A. Powers D. G. Robinson D. L. Potter G. C. Bessette H. J. MacLean J. C. Hewson J. E. Kelly K. E. Metzinger N. E. Bixler R. J. Lipinski

2006-01-01

341

Advanced Test Reactor Critical Facility safety analysis report five year currency review  

Microsoft Academic Search

By DOE-ID Order 5481.1A, a five year currency review is required of the Safety Analysis Reports of all ID or ID contractor operations having hazards of a type and magnitude not routinely encountered and\\/or accepted by the public. In keeping with this order, a currency review has been performed of the Advanced Test Reactor Critical Facility (ADTRC) Safety Analysis Report

P. R. Napper; W. R. Carpenter; R. W. Garner

1991-01-01

342

Considering consumers' food safety perceptions at the WTO -level: a survey-based analysis  

Microsoft Academic Search

Abstract The WTO frame for food safety policy follows the structure of risk analysis, i.e. consists of rules re- garding the three components of risk assessment, management and communication. The analysis of the WTO rules and of the findings of closed disputes identifies a strong orientation on science as well asan,approach ,to harmonise ,food safety standards by basing,them on the

Bettina Rudloff; Johannes Simons

343

Transuranic-contaminated solid waste Treatment Development Facility. Final safety analysis report  

Microsoft Academic Search

The Final Safety Analysis Report (FSAR) for the Transuranic-Contaminated Solid-Waste Treatment Facility has been prepared in compliance with the Department of Energy (DOE) Manual Chapter 0531, Safety of Nonreactor Nuclear Facilities. The Treatment Development Facility (TDF) at the Los Alamos Scientific Laboratory is a research and development facility dedicated to the study of radioactive-waste-management processes. This analysis addresses site assessment,

1979-01-01

344

Taxonomy of Ganoderma lucidum from Korea Based on rDNA and Partial ?-Tubulin Gene Sequence Analysis  

PubMed Central

In the present study, a phylogenetic analysis was undertaken based on the internal transcribed spacer (ITS) rDNA and partial ?-tubulin gene sequence of the Ganoderma species. The size of the ITS rDNA regions from different Ganoderma species varied from 625 to 673 bp, and those of the partial ?-tubulin gene sequence were 419 bp. Based on the results, a phylogenetic tree was prepared which revealed that Korean Ganoderma lucidum strains belong in a single group along with a G. lucidum strain from Bangladesh.

Park, Young-Jin; Kwon, O-Chul; Son, Eun-Suk; Yoon, Dae-Eun; Han, Woorijarang; Yoo, Young-Bok

2012-01-01

345

Sodium fast reactor gaps analysis of computer codes and models for accident analysis and reactor safety.  

SciTech Connect

This report summarizes the results of an expert-opinion elicitation activity designed to qualitatively assess the status and capabilities of currently available computer codes and models for accident analysis and reactor safety calculations of advanced sodium fast reactors, and identify important gaps. The twelve-member panel consisted of representatives from five U.S. National Laboratories (SNL, ANL, INL, ORNL, and BNL), the University of Wisconsin, the KAERI, the JAEA, and the CEA. The major portion of this elicitation activity occurred during a two-day meeting held on Aug. 10-11, 2010 at Argonne National Laboratory. There were two primary objectives of this work: (1) Identify computer codes currently available for SFR accident analysis and reactor safety calculations; and (2) Assess the status and capability of current US computer codes to adequately model the required accident scenarios and associated phenomena, and identify important gaps. During the review, panel members identified over 60 computer codes that are currently available in the international community to perform different aspects of SFR safety analysis for various event scenarios and accident categories. A brief description of each of these codes together with references (when available) is provided. An adaptation of the Predictive Capability Maturity Model (PCMM) for computational modeling and simulation is described for use in this work. The panel's assessment of the available US codes is presented in the form of nine tables, organized into groups of three for each of three risk categories considered: anticipated operational occurrences (AOOs), design basis accidents (DBA), and beyond design basis accidents (BDBA). A set of summary conclusions are drawn from the results obtained. At the highest level, the panel judged that current US code capabilities are adequate for licensing given reasonable margins, but expressed concern that US code development activities had stagnated and that the experienced user-base and the experimental validation base was decaying away quickly.

Carbajo, Juan (Oak Ridge National Laboratory, Oak Ridge, TN); Jeong, Hae-Yong (Korea Atomic Energy Research Institute, Daejeon, Korea); Wigeland, Roald (Idaho National Laboratory, Idaho Falls, ID); Corradini, Michael (University of Wisconsin, Madison, WI); Schmidt, Rodney Cannon; Thomas, Justin (Argonne National Laboratory, Argonne, IL); Wei, Tom (Argonne National Laboratory, Argonne, IL); Sofu, Tanju (Argonne National Laboratory, Argonne, IL); Ludewig, Hans (Brookhaven National Laboratory, Upton, NY); Tobita, Yoshiharu (Japan Atomic Energy Agency, Ibaraki-ken, Japan); Ohshima, Hiroyuki (Japan Atomic Energy Agency, Ibaraki-ken, Japan); Serre, Frederic (Centre d'%C3%94etudes nucl%C3%94eaires de Cadarache %3CU%2B2013%3E CEA, France)

2011-06-01

346

Review of physics methodology of ATR safety analysis.  

National Technical Information Service (NTIS)

At the request of EG&G Idaho, the Pacific Northwest Laboratory (PNL) performed a brief review of the physics methods employed in the safety analyses for the Advanced Test Reactor. PNL determined that the general approach used by EG&G was sound. Comparison...

W. W. Little S. W. Heaberlin

1991-01-01

347

The application of new mathematical structures to safety analysis  

Microsoft Academic Search

Probabilistic safety analyses (PSAs) often depend on significant subjectivity. The recent successes of fuzzy logic and fuzzy and hybrid mathematics in portraying subjectivity is a reminder that a selection made from the most applicable mathematical tools is more important than forced adaptation of conventional tools. We consider new approaches that enhance conventional and fuzzy PSA by improved handling of subjectivity.

J. Arlin Cooper; Timothy J. Ross

1998-01-01

348

Safety valve dynamic instability: An analysis of chatter  

Microsoft Academic Search

Safety valve chatter, which is characterized by violent oscillation of the disk or closure member, is a dynamical phenomenon representable by differential rather than algebraic equations. It is shown that the conditions necessary for avoiding chatter may be determined from the behavior of the differential equations in the region of certain critical points. The paper demonstrates how to determine these

G. MacLeod

1985-01-01

349

Safety Analysis and Review System for coal utilization technology development  

Microsoft Academic Search

Among the alternative sources and technologies are those being developed by the US Department of Energy's Fossil Energy Program. They include coal liquefaction, coal gasification, fluidized-bed combustion, enhanced oil and gas recovery, underground coal gasification, coalbed methane drainage, oil shale extraction, and others. Developing these technologies requires comprehensive, advanced planning to control safety and health hazards, environmental impacts, and property

J. H. Capps; J. D. Pearson

1980-01-01

350

Risk analysis as a basis for safety management system  

Microsoft Academic Search

The paper shows, with a practical application, how the hazard identification and evaluation phase of the Safety Management System (SMS) in a major risk installation (as defined by EC Directive CEE 96\\/82 (Seveso II) is the sizing criteria for the whole SMS, with its procedures. Probabilistic risk assessment techniques are applied to a foaming agent production plant. The links between

Micaela Demichela; Norberto Piccinini; Alfredo Romano

2004-01-01

351

Is risk analysis a useful tool for improving process safety?  

Microsoft Academic Search

To improve safety one has to know where risks are. For determining risks, hazards have to be identified and representative accident scenarios defined. This needs effort and technique. Man is quite limited in foresight without having experience and lessons from the past. For knowing the risk of an incidental, undesired event both its severity and probability has to be estimated.

H. J. Pasman; S. Jung; K. Prem; W. J. Rogers; X. Yang

2009-01-01

352

Analysis and modification of amorphous and partially-crystalline thin films  

SciTech Connect

Thin films of light atomic weight elements in amorphous, partially-crystalline, or crystalline forms have applications in a broad range of technologies. For example, amorphous tetrahedral carbon (a-tC) and polymeric thin films impact electronic materials technology as electron- and light-emitting device elements, respectively. A lack of crystallinity introduces complexity in the experimental and theoretical characterization of these materials but is not necessarily a limiting factor in their performance. While the growth process is clearly a major factor governing the physical properties of a film, interactions with the substrate are also important, so surface and interface analysis provides an important complement to bulk measurements. This paper focuses on several approaches in the characterization and modification of thin films made possible by recent experimental advances. The structural and electronic properties of two model systems are considered as examples: a-tC thin films grown by pulsed laser deposition (PLD) and polyaniline thin films grown by vapor deposition. First, scanning probe microscopies and X-ray scattering are used to investigate the structural aspects of a-tC films as a function of PLD growth conditions. The possible connection of nanoscale surface modification and characterization with electron emission properties will be discussed. Second, the results of inelastic scattering spectroscopy and other surface techniques will be discussed to obtain information on both interfacial aspects of the growth of polyaniline thin films and microscopic and macroscopic aspects of electrical conductivity upon doping. Comparisons will be made with other studies that address properties of analogous crystalline systems as appropriate. A brief assessment of the broader problem of analyzing these systems will be given.

DiNardo, N.J.; Mercer, T.W. [Drexel Univ., Philadelphia, PA (United States). Dept. of Physics; Martinez-Miranda, L.J. [Univ. of Maryland, College Park, MD (United States). Dept. of Materials and Nuclear Engineering; Siegal, M.P.; Friedmann, T.A.; Sullivan, J.R. [Sandia National Labs., Albuquerque, NM (United States); Plank, R.V.; Vohs, J.M. [Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Chemical Engineering

1997-12-01

353

Mitochondrial gene rearrangements and partial genome duplications detected by multigene asymmetric compositional bias analysis.  

PubMed

Asymmetric compositional and mutation bias between the two strands occurs in mitochondrial genomes, and an asymmetric mechanism of mtDNA replication is a potential source of this bias. Some evidence indicates that during replication the heavy strand is subject to a gradient of time spent in a single-stranded state (D (ssH)) and a gradient of mutational damage. The nucleotide composition bias among genes varies with D (ssH). Consequently, partial genome duplications (PGD) will alter the skew for genes located downstream of the duplication, relatively to nascent light strand synthesis, and in the same way, gene rearrangements (GRr) will affect genes by changing their skews. We examined cases where there had been PGD or GRr and determined whether this left a trace in the form of unusual patterns of base composition. We compared the skew of genes differently located on the mtDNA genome of previously published whole mtDNA genomes from amphibians, a group that shows considerable levels of both GRr and PGD. After observing a significant correlation between AT and GC skew with D (ssH) at fourfold redundant sites, we ran our analysis and detected 31.3% of the species with GRr and/or PGD. By comparing the nucleotide composition at fourfold redundant sites in normal and "abnormal" species, we found that A/C variation occurs and is associated with GRr/PGD. These results show that by analyzing the nucleotide skews of only three genes, it may be possible to predict some mitochondrial GRr and/or PGD without knowing the complete mtDNA genome sequence. PMID:17075699

Fonseca, Miguel M; Froufe, Elsa; Harris, D James

2006-10-29

354

14 CFR Appendix J to Part 417 - Ground Safety Analysis Report  

Code of Federal Regulations, 2013 CFR

...processing as defined by section I417.7(m) of appendix I of this part for each launch that involves the use of any toxic propellants. (d) Hazard analysis. A ground safety analysis report must include a chapter containing a hazard analysis of...

2013-01-01

355

Oak Ridge National Laboratory site data for safety-analysis report  

SciTech Connect

The Oak Ridge National Laboratory site data contained herein were compiled in support of the United States Department of Energy (USDOE) Oak Ridge Operations Office Order OR 5481.1. That order sets forth assignment of responsibilities for safety analysis and review responsibilities and provides guidance relative to the content and format of safety analysis reports. The information presented in this document is intended for use by reference in individual safety analysis reports where applicable to support accident analyses or the establishment of design bases of significance to safety, and it is applicable only to Oak Ridge National Laboratory facilities in Bethel and Melton Valleys. This information includes broad descriptions of the site characteristics, radioactive waste handling and monitoring practices, and the organization and operating policies at Oak Ridge National Laboratory. The historical background of the Laboratory is discussed briefly and the overall physical situation of the facilities is described in the following paragraphs.

Fitzpatrick, F.C.

1982-12-01

356

14 CFR 417.233 - Analysis for an unguided suborbital launch vehicle flown with a wind weighting safety system.  

Code of Federal Regulations, 2013 CFR

14 Aeronautics and Space 4 2013-01-01 2013-01-01...Section 417.233 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION...TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis §...

2013-01-01

357

Framework for Cost-Benefit Analysis of the Dutch Road Safety Plan (Opplegg for Nytte-Kostnadsanalyse av Nederlands Trafikksikkerhetsplan).  

National Technical Information Service (NTIS)

The report describes a framework for cost-benefit analysis of the Dutch road safety plan. it discusses the concept of sustainable safety and estimates revised road accident costs for the Netherlands. The effects of various measures is discussed. Examples ...

R. Elvik

1997-01-01

358

Use of PCs and workstations for criticality safety analysis  

SciTech Connect

Making effective use of the best available computer technology has long been a feature of U.K. criticality safety analyses. In recent years, the industry's drive for improvements in design safety assessment practice has been supplemented by increasing commercial awareness, bringing further emphasis to the consideration of cost-effectiveness in criticality computation. Consequently, there has been an evolution of computing facilities seen by U.K. criticality assessors from the mainframe terminals of the 1970s through minicomputers in the 1980s to graphical workstations and, most recently, personal computers (PCs) in the 1990s. These moves have been initiated by the availability of hardware capable of providing adequate performance and facilitated by cooperation and subsequently formal collaboration between British Nuclear Fuels Limited (BNFL) and the Atomic Energy Authority (AEA) in the field of software development.

Watmough, M.H.; Evans, A.M. (British Nuclear Fuels Ltd., Cheshire (United Kingdom)); Smith, N.R. (AEA Technology, Dorchester (United Kingdom))

1993-01-01

359

Gastrointestinal safety profile of nabumetone: a meta-analysis  

Microsoft Academic Search

Individual comparative studies suggest that nabumetone has a gastrointestinal (GI) safety profile superior to comparator NSAIDs but lack power to show a statistical difference. The aim of this study was to evaluate systematically the difference in GI adverse events—especially the rate of perforations, ulcers, and bleeds (PUBs)—between studies, meta-analyses of comparative trials of nabumetone and conventional NSAIDs, and postmarketing, open-label

Jia-Qing Huang; Subbaramiah Sridhar; Richard H Hunt

1999-01-01

360

National Synchrotron Light Source safety-analysis report  

SciTech Connect

This document covers all of the safety issues relating to the design and operation of the storage rings and injection system of the National Synchrotron Light Source. The building systems for fire protection, access and egress are described together with air and other gaseous control or venting systems. Details of shielding against prompt bremstrahlung radiation and synchrotron radiation are described and the administrative requirements to be satisfied for operation of a beam line at the facility are given.

Batchelor, K. (ed.)

1982-07-01

361

Analysis of developed transition road safety barrier systems.  

PubMed

Road safety barriers protect vehicles from roadside hazards by redirecting errant vehicles in a safe manner as well as providing high levels of safety during and after impact. This paper focused on transition safety barrier systems which were located at the point of attachment between a bridge and roadside barriers. The aim of this study was to provide an overview of the behavior of transition systems located at upstream bridge rail with different designs and performance levels. Design factors such as occupant risk and vehicle trajectory for different systems were collected and compared. To achieve this aim a comprehensive database was developed using previous studies. The comparison showed that Test 3-21, which is conducted by impacting a pickup truck with speed of 100 km/h and angle of 25° to transition system, was the most severe test. Occupant impact velocity and ridedown acceleration for heavy vehicles were lower than the amounts for passenger cars and pickup trucks, and in most cases higher occupant lateral impact ridedown acceleration was observed on vehicles subjected to higher levels of damage. The best transition system was selected to give optimum performance which reduced occupant risk factors using the similar crashes in accordance with Test 3-21. PMID:23820073

Soltani, Mehrtash; Moghaddam, Taher Baghaee; Karim, Mohamed Rehan; Sulong, N H Ramli

2013-06-05

362

Model-based process analysis of partial nitrification efficiency under dynamic nitrogen loading  

Microsoft Academic Search

In this study, the ammonia removal efficiency for high ammonia-containing wastewaters was evaluated via partial nitrification.\\u000a A nitrifier biocommunity was first enriched in a fill-and-draw batch reactor with a specific ammonium oxidation rate of 0.1 mg NH4\\u000a ?-N\\/mg VSS.h. Partial nitrification was established in a chemostat at a hydraulic retention time (HRT) of 1.15 days, which\\u000a was equal to the sludge retention time

Didem Güven; Özgül Kutlu; Güçlü ?nsel; Seval Sözen

2009-01-01

363

Process hazards analysis (PrHA) program, bridging accident analyses and operational safety  

SciTech Connect

Recently the Final Safety Analysis Report (FSAR) for the Plutonium Facility at Los Alamos National Laboratory, Technical Area 55 (TA-55) was revised and submitted to the US. Department of Energy (DOE). As a part of this effort, over seventy Process Hazards Analyses (PrHAs) were written and/or revised over the six years prior to the FSAR revision. TA-55 is a research, development, and production nuclear facility that primarily supports US. defense and space programs. Nuclear fuels and material research; material recovery, refining and analyses; and the casting, machining and fabrication of plutonium components are some of the activities conducted at TA-35. These operations involve a wide variety of industrial, chemical and nuclear hazards. Operational personnel along with safety analysts work as a team to prepare the PrHA. PrHAs describe the process; identi fy the hazards; and analyze hazards including determining hazard scenarios, their likelihood, and consequences. In addition, the interaction of the process to facility systems, structures and operational specific protective features are part of the PrHA. This information is rolled-up to determine bounding accidents and mitigating systems and structures. Further detailed accident analysis is performed for the bounding accidents and included in the FSAR. The FSAR is part of the Documented Safety Analysis (DSA) that defines the safety envelope for all facility operations in order to protect the worker, the public, and the environment. The DSA is in compliance with the US. Code of Federal Regulations, 10 CFR 830, Nuclear Safety Management and is approved by DOE. The DSA sets forth the bounding conditions necessary for the safe operation for the facility and is essentially a 'license to operate.' Safely of day-to-day operations is based on Hazard Control Plans (HCPs). Hazards are initially identified in the PrI-IA for the specific operation and act as input to the HCP. Specific protective features important to worker safety are incorporated so the worker can readily identify the safety parameters of the their work. System safety tools such as Preliminary Hazard Analysis, What-If Analysis, Hazard and Operability Analysis as well as other techniques as necessary provide the groundwork for both determining bounding conditions for facility safety, operational safety, and day-to-clay worker safety.

Richardson, J. A. (Jeanne A.); McKernan, S. A. (Stuart A.); Vigil, M. J. (Michael J.)

2003-01-01

364

Cognitive-behavioral approaches to farm community safety education: a conceptual analysis.  

PubMed

For many years, farm health and safety education efforts have focused on the presentation of safety rules and guidelines. This method of instruction tends to ignore the contingencies that influence the actual behavior of farmers. Consequently, while most farmers understand the safety instruction messages they receive, they frequently continue to engage in risky behaviors. They do so even when they are aware of the injury consequences that can result from engaging in risky behaviors during farm work. Consequently, educational programs for the delivery of farm health and safety knowledge have been judged to be of questionable effectiveness. Yet, current political, social, and economic realities suggest that safety and health education will remain a favored methodology for the foreseeable future. These observations suggest that farm safety education efforts may need to be reconceptualized. This article examines the learning of safe and unsafe work practices from three historical learning theory perspectives: behaviorism, constructivism, and socioculturalism. The conceptual analysis is illustrated through case study examples. The analysis may provide insights into why transmission of knowledge by itself is not effective for replacing risky behaviors with safe work practices. It may also assist the design of farm health and safety education programs that impart knowledge, as well as change attitudes and behavior that support safe work practices. PMID:12046802

Cole, H P

2002-05-01

365

Mechanical engineering note - safety analysis of molten uranium/water interaction in the uranium foundry furnace  

SciTech Connect

This Engineering Note describes the development of the accident criteria used the basis for the design of the uranium foundry vacuum vessel. The results of this analysis provide input into other safety notes that investigate how well the uranium containment boundary will maintain its integrity during the design basis accident. The preventative measures that have been designed into the system to minimize the potential to produce a flammable gas mixture are described. The system response is designed for consistency with applicable sections of the LLNL Health and Safety Manual, as well as the Mechanical engineering Safety Design Standards.

Gourdin, W H; Sze, J

1999-08-19

366

School food safety program based on hazard analysis and critical control point principles. Final rule.  

PubMed

This final rule implements a legislative provision which requires school food authorities participating in the National School Lunch Program (NSLP) or the School Breakfast Program (SBP) to develop a school food safety program for the preparation and service of school meals served to children. The school food safety program must be based on the hazard analysis and critical control point (HACCP) system established by the Secretary of Agriculture. The food safety program will enable schools to take systematic action to prevent or minimize the risk of foodborne illness among children participating in the NSLP and SBP. PMID:20169679

2009-12-15

367

Partial Dictation as a Measure of EFL Listening Proficiency: Evidence from Confirmatory Factor Analysis  

ERIC Educational Resources Information Center

Partial dictation is a measure of EFL listening proficiency that can be easily constructed, administered, and scored by EFL teachers. However, it is controversial whether this form of test measures lower-order abilities exclusively or involves both lower- and higher-order abilities. In order to answer this question, a study was designed to examine…

Cai, Hongwen

2013-01-01

368

Parent Ratings of ADHD Symptoms: Generalized Partial Credit Model Analysis of Differential Item Functioning across Gender  

ERIC Educational Resources Information Center

|Objective: Generalized partial credit model, which is based on item response theory (IRT), was used to test differential item functioning (DIF) for the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.), inattention (IA), and hyperactivity/impulsivity (HI) symptoms across boys and girls. Method: To accomplish this, parents…

Gomez, Rapson

2012-01-01

369

Linking Socioeconomic Status to Social Cognitive Career Theory Factors: A Partial Least Squares Path Modeling Analysis  

ERIC Educational Resources Information Center

|The purpose of this study was to investigate the contributions of socioeconomic status (SES) in predicting social cognitive career theory (SCCT) factors. Data were collected from 738 college students in Taiwan. The results of the partial least squares (PLS) analyses indicated that SES significantly predicted career decision self-efficacy (CDSE);…

Huang, Jie-Tsuen; Hsieh, Hui-Hsien

2011-01-01

370

The Development and Performance Analysis of Partially Premixed LPG Porous Medium Combustor  

Microsoft Academic Search

Porous medium combustion has interesting advantages compared with free flame combustion due to higher burning rates, an increased power dynamic range, extension of the lean flammability limits, and low emissions of pollutants. This article presents the development and testing of a partially premixed porous medium combustor with liquified petroleum gas as fuel. The discrete porous medium is made up of

R. M. N. Muhad; M. Z. Abdullah; M. Abdul Mujeebu; M. Z. Abu Bakar; R. Zakaria; A. A. Mohamad

2011-01-01

371

Analysis of the Activated Partial Thromboplastin Time Test Using Mathematical Modeling  

Microsoft Academic Search

Activated partial thromboplastin time (APTT) is a laboratory test for the diagnosis of blood coagulation disorders. The test consists of two stages: The first one is the preincubation of a plasma sample with negatively charged materials (kaolin, ellagic acid etc.) to activate factors XII and XI; the second stage begins after the addition of calcium ions that triggers a chain

Alexander E. Kogan; Denis V. Kardakov; Mikhail A. Khanin

2001-01-01

372

Linking Socioeconomic Status to Social Cognitive Career Theory Factors: A Partial Least Squares Path Modeling Analysis  

ERIC Educational Resources Information Center

The purpose of this study was to investigate the contributions of socioeconomic status (SES) in predicting social cognitive career theory (SCCT) factors. Data were collected from 738 college students in Taiwan. The results of the partial least squares (PLS) analyses indicated that SES significantly predicted career decision self-efficacy (CDSE);…

Huang, Jie-Tsuen; Hsieh, Hui-Hsien

2011-01-01

373

Pregabalin versus gabapentin in partial epilepsy: a meta-analysis of dose-response relationships  

Microsoft Academic Search

BACKGROUND: To compare the efficacy of pregabalin and gabapentin at comparable effective dose levels in patients with refractory partial epilepsy. METHODS: Eight randomized placebo controlled trials investigating the efficacy of pregabalin (4 studies) and gabapentin (4 studies) over 12 weeks were identified with a systematic literature search. The endpoints of interest were \\

Philippa Delahoy; Sally Thompson; Ian C Marschner

2010-01-01

374

Analysis of a partial scram event in a typical BWR\\/4  

Microsoft Academic Search

A study has been made of core thermal-hydraulic conditions and containment suppression pool water temperature following a partial failure to scram in a BWR 4. This was motivated by the occurrence of such an incident in the Browns Ferry Unit 3. If suppression pool temperature should rise too much, the effectiveness of the suppression pool can be impaired. However, the

M. S. Lu; W. Shier; M. M. Levine; R. Cerbone

1982-01-01

375

Partial least squares, Beer's law and the net analyte signal: statistical modeling and analysis  

Microsoft Academic Search

Partial least squares (PLS) is one of the most common regression algorithms in chemistry, relating input-output samples (xi, yi) by a linear multivariate model. In this paper we analyze the PLS algorithm under a specific probabilistic model for the relation between x and y. Following Beer's law, we assume a linear mixture model in which each data sample (x, y)

Boaz Nadler; Ronald R. Coifman

2005-01-01

376

Stochastic analysis of solute transport in partially saturated heterogeneous soil 1. Numerical experiments  

Microsoft Academic Search

The effect of water saturation on the transport of a conservative, nonreactive solute pulse by quasi steady state and transient flows in a vertical cross section of a hypothetical, yet realistic heterogeneous, partially saturated soil has been analyzed here by a series of numerical experiments. Mean water saturation in the flow domain was controlled by predetermined capillary pressure head at

David Russo; Jacob Zaidel; Asher Laufer

1994-01-01

377

Access to European dairy product markets: A Computable Partial Equilibrium analysis to assess Argentine exporters surplus  

Microsoft Academic Search

A partial equilibrium model is used to quantify price differentials not explained by tax policy and efficiency cost in the international trade of dairy products between Argentina and some countries of European Union (EU). Prices of imports of EU from Argentina and European producer of the domestic variety welfare fall when liberalization of non-tariff barriers are reduced or eliminated as

Sonia M. León; Mauricio E. Roitman; Carlos A. Romero

2008-01-01

378

Review of physics methodology of ATR safety analysis  

SciTech Connect

At the request of EG G Idaho, the Pacific Northwest Laboratory (PNL) performed a brief review of the physics methods employed in the safety analyses for the Advanced Test Reactor. PNL determined that the general approach used by EG G was sound. Comparisons were made between the EG G results and a simplified PBL model. These demonstrated good agreement. However, the lack of spacial treatment of the moderator density reactivity coefficient and exclusion of the test loops from the reactivity model were identified as potential problems. In addition to these two concerns, a series of more minor observations were offered to assist EG G in their analyses. 2 refs., 2 figs.

Little, W.W.; Heaberlin, S.W.

1991-09-01

379

Waste Sampling & Characterization Facility (WSCF) Complex Safety Analysis  

SciTech Connect

This document was prepared to analyze the Waste Sampling and Characterization Facility for safety consequences by: Determining radionuclide and highly hazardous chemical inventories; Comparing these inventories to the appropriate regulatory limits; Documenting the compliance status with respect to these limits; and Identifying the administrative controls necessary to maintain this status. The primary purpose of the Waste Sampling and Characterization Facility (WSCF) is to perform low-level radiological and chemical analyses on various types of samples taken from the Hanford Site. These analyses will support the fulfillment of federal, Washington State, and Department of Energy requirements.

MELOY, R.T.

2002-04-01

380

Oral Contribution: Partial wave analysis of J/? ? pbar p?0 and measurement of J/? ? pbar p?, pbar p??  

NASA Astrophysics Data System (ADS)

Based on 58 million J/? data collected with the BES II detector at the BEPC, Partial Wave Analysis(PWA) is performed on J/? ? pbar p?0. The new excited baryon N(2065) is confirmed. Clear signals for other N* states are observed and the corresponding masses, widths and spin-parity are also measured. Processes such as J/? ? pbar p?, pbar p?? are also studied and the branching ratios are measured.

Yang, Hong-Xun; BES Collaboration II

2009-12-01

381

Determination of glucose content by means of visible micro-Raman spectroscopy and interval partial least square multivariate analysis  

Microsoft Academic Search

Micro-Raman spectroscopy and interval Partial Least Square (iPLS) multivariate analysis have been used for determining glucose concentration in various commercial sport drinks. By employing a visible excitation light (633 nm), micro- Raman spectra in the 600-1600 cm -1 wavenumber shift region have been recorded, showing well defined and separated vibrational fingerprints of the various contained sugars (glucose, fructose and sucrose).

M. Lepore; M. Portaccio; B. Della Ventura; L. Mita; D. G. Mita; C. Camerlingo; I. Delfino

2011-01-01

382

Mellin-Transform-Based Performance Analysis of FFH -ary FSK Using Product Combining for Combatting Partial-Band Noise Jamming  

Microsoft Academic Search

We employ the Mellin transform to facilitate the bit error ratio (BER) analysis of a fast frequency hopping (FFH)-assisted, M-ary frequency-shift keying (MFSK) using product combining (PC) when the transmitted signal is subjected to both Rayleigh fading and partial-band noise jamming. Exploiting the fact that the Mellin transform of the product of independent random variables is the product of their

Sohail Ahmed; Lie-Liang Yang; Lajos Hanzo

2008-01-01

383

HPLC\\/APCI-FTICR-MS as a tool for identification of partial polar mutagenic compounds in effect-directed analysis  

Microsoft Academic Search

Identification of unknown compounds remains one of the biggest challenges for the assignment of adverse effects of sediment\\u000a contamination and other complex environmental mixtures to responsible toxicants by effect-directed analysis (EDA). The identification\\u000a depends on information gained from biotesting, chromatographic separation, and mass spectrometric detection. Thus, a methodology\\u000a is provided for non-target identification of partial polar mutagenic polyaromatic compounds in

Mahmoud Bataineh; Urte Lübcke-von Varel; Heiko Hayen; Werner Brack

2010-01-01

384

Griseofulvin\\/Carrier Blends: Application of Partial Least Squares (PLS) Regression Analysis for Estimating the Factors Affecting the Dissolution Efficiency  

Microsoft Academic Search

The main aim of the present study was to estimate the carrier characteristics affecting the dissolution efficiency of Griseofulvin\\u000a (Gris) containing blends (BLs) using partial least squares (PLS) regression analysis. These systems were prepared at three\\u000a different drug\\/carrier weight ratios (1\\/5, 1\\/10, and 1\\/20) by the solvent evaporation method, a well-established method for\\u000a preparing solid dispersions (SDs). The carriers used

Annalisa Cutrignelli; Adriana Trapani; Angela Lopedota; Massimo Franco; Delia Mandracchia; Nunzio Denora; Valentino Laquintana; Giuseppe Trapani

385

Overheads, Safety Analysis and Engineering FY 1995 Site Support Program Plan WBS 6.3.5  

SciTech Connect

The Safety Analysis & Engineering (SA&E) department provides core competency for safety analysis and risk documentation that supports achievement of the goals and mission as described in the Hanford Mission Plan, Volume I, Site Guidance (DOE-RL 1993). SA&E operations are integrated into the programs that plan and conduct safe waste management, environmental restoration, and operational activities. SA&E personnel are key members of task teams assigned to eliminate urgent risks and inherent threats that exist at the Hanford Site. Key to ensuring protection of public health and safety, and that of onsite workers, are the products and services provided by the department. SA&E will continue to provide a leadership role throughout the DOE complex with innovative, cost-effective approaches to ensuring safety during environmental cleanup operations. The SA&E mission is to provide support to direct program operations through safety analysis and risk documentation and to maintain an infrastructure responsive to the evolutionary climate at the Hanford Site. SA&E will maintain the appropriate skills mix necessary to fulfill the customers need to conduct all operations in a safe and cost-effective manner while ensuring the safety of the public and the onsite worker.

DiVincenzo, E.P.

1994-09-27

386

Review and Analysis of Development of "Safety by Design" Requirements  

SciTech Connect

This report, the deliverable for Task 4 of the NA-243 Safeguards by Design Work Plan for Fiscal Year 2009, develops the lessons to be learned for the institutionalization of Safeguards By Design (SBD) from the Department of Energy (DOE) experience developing and implementing DOE-STD-1189, Integration of Safety into the Design Process. This experience was selected for study because of the similarity of the challenges of integrating safety and safeguards into the design process. Development of DOE-STD-1189 began in January 2006 and the standard was issued for implementation in March 2008. The process was much more time consuming than originally anticipated and might not have come to fruition had senior DOE management been less committed to its success. Potentially valuable lessons can be learned from both the content and presentation of the integration approach in DOE-STD-1189 and from the DOE experience in developing and implementing DOE-STD-1189. These lessons are important because the instutionalization of SBD does not yet appear to have the level of senior management commitment afforded development and implementation of DOE-STD-1189.

Vance, Scott A.; Hockert, John

2009-10-20

387

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2010 CFR

...must: (1) Follow a standard industry methodology such as a fault tree analysis or a failure modes effects and criticality analysis; (2) Identify all possible failure modes and undesired events, their probability of occurrence, and...

2009-01-01

388

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2010 CFR

...must: (1) Follow a standard industry methodology such as a fault tree analysis or a failure modes effects and criticality analysis; (2) Identify all possible failure modes and undesired events, their probability of occurrence, and...

2010-01-01

389

Structure soil structure interaction effects: Seismic analysis of safety related collocated concrete structures  

Microsoft Academic Search

The Process, Purification and Stack Buildings are collocated safety related concrete shear wall structures with plan dimensions in excess of 100 feet. An important aspect of their seismic analysis was the determination of structure soil structure interaction (SSSI) effects, if any. The SSSI analysis of the Process Building, with one other building at a time, was performed with the SASSI

2000-01-01

390

Combining functional and structural reasoning for safety analysis of electrical designs  

Microsoft Academic Search

Increasing complexity of design in automotive electrical systems has been paralleled by increased demands for analysis of the safety and reliability aspects of those designs. Such demands can place a great burden on the engineers charged with carrying out the analysis. This paper describes how the intended functions of a circuit design can be combined with a qualitative model of

C. J. PRICE; J. E. HUNT; M. S. WILSON

1997-01-01

391

Benefit-Cost Analysis in Environmental, Health, and Safety Regulation: A Statement of Principles  

Microsoft Academic Search

Benefit-cost analysis can play a very important role in legislative and regulatory policy debates on improving the environment, health, and safety. It can help illustrate the tradeoffs that are inherent in public policymaking as well as make those tradeoffs more transparent. It can also help agencies set regulatory priorities. Benefit-cost analysis should be used to help decisionmakers reach a decision.

Kenneth J. Arrow; Maureen L. Cropper; George C. Eads; Robert W. Hahn; Lester B. Lave; Roger G. Noll; Paul R. Portney; Milton Russell; Richard L. Schmalensee; V. Kerry Smith; Robert N. Stavins

1996-01-01

392

Comparative policy analysis of coal-mine safety regulation in the United States and Poland  

Microsoft Academic Search

The study concerns an analysis of the factors which influence death rates in coal mines in the United States and Poland. The study uses multiple regression and time series analysis on data since the end of World War II. A formal causal model is derived from political economy literatures and safety studies to analyze the determinants of death rates. Independent

1983-01-01

393

Evaluation of Safety in a Radiation Oncology Setting Using Failure Mode and Effects Analysis  

Microsoft Academic Search

Purpose: Failure mode and effects analysis (FMEA) is a widely used tool for prospectively evaluating safety and reliability. We report our experiences in applying FMEA in the setting of radiation oncology. Methods and Materials: We performed an FMEA analysis for our external beam radiation therapy service, which consisted of the following tasks: (1) create a visual map of the process,

Eric C. Ford; Ray Gaudette; Lee Myers; Bruce Vanderver; Lilly Engineer; Richard Zellars; Danny Y. Song; John Wong; Theodore L. DeWeese

2009-01-01

394

Safety Analysis of the Blind Shaft Borer. Volume 4. Safety Manual.  

National Technical Information Service (NTIS)

The results of this analysis show generally that both BSB systems are safer than conventional shaft sinking. The potential risk of conventional shaft sinking operations could be reduced by over 30%, on the average, with the use of the original BSB system,...

C. A. Geffen-Fowler J. M. Hobbs J. J. Jacobsen J. M. Oylear T. B. Powers

1981-01-01

395

Element-free Galerkin (EFG) method for analysis of the time-fractional partial differential equations  

NASA Astrophysics Data System (ADS)

The present paper deals with the numerical solution of time-fractional partial differential equations using the element-free Galerkin (EFG) method, which is based on the moving least-square approximation. Compared with numerical methods based on meshes, the EFG method for time-fractional partial differential equations needs only scattered nodes instead of meshing the domain of the problem. It neither requires element connectivity nor suffers much degradation in accuracy when nodal arrangements are very irregular. In this method, the first-order time derivative is replaced by the Caputo fractional derivative of order ? (0 < ? < 1). The Galerkin weak form is used to obtain the discrete equations, and the essential boundary conditions are enforced by the penalty method. Several numerical examples are presented and the results we obtained are in good agreement with the exact solutions.

Ge, Hong-Xia; Liu, Yong-Qing; Cheng, Rong-Jun

2012-01-01

396

Applications of chaos theory on Partial Discharge detection and character analysis  

Microsoft Academic Search

Partial discharge (PD) signals character analyzing and interference suppressing are very important for PD on-line measurement. In this paper, chaos theory is introduced in the PD on-line monitoring. The mechanism of PD phenomena has been researched by series of typical insulation defect PD experiments in the lab. Through calculating the non-linear dynamics character of PD detecting signal time sequence, such

Chelai Yin; Lixing Zhou; Yini Luo

2008-01-01

397

Sequence analysis of the partial spike glycoprotein gene of porcine epidemic diarrhea viruses isolated in Korea  

Microsoft Academic Search

Porcine epidemic diarrhea virus (PEDV) causes a devastating enteric disease with acute diarrhea, dehydration and significant\\u000a mortality in swine, thereby incurring heavy economic losses in Korea. Spike (S) glycoprotein has been suggested as an important\\u000a determinant for PEDV biological properties. In this study, the nucleotide and deduced amino acid sequences of the partial\\u000a S glycoprotein genes of Korean PEDV isolates,

Seong-Jun Park; Hyoung-Joon Moon; Jeong-Sun Yang; Chul-Seung Lee; Dae-Sub Song; Bo-Kyu Kang; Bong-Kyun Park

2007-01-01

398

Stress and strain analysis of contractions during ramp distension in partially obstructed guinea pig jejunal segments  

PubMed Central

Previous studies have demonstrated morphological and biomechanical remodeling in the intestine proximal to an obstruction. The present study aimed to obtain stress and strain thresholds to initiate contraction and the maximal contraction stress and strain in partially obstructed guinea pig jejunal segments. Partial obstruction and sham operations were surgically created in mid-jejunum of male guinea pigs. The animals survived 2, 4, 7, and 14 days, respectively. Animals not being operated on served as normal controls. The segments were used for no-load state, zero-stress state and distension analyses. The segment was inflated to 10 cmH2O pressure in an organ bath containing 37°C Krebs solution and the outer diameter change was monitored. The stress and strain at the contraction threshold and at maximum contraction were computed from the diameter, pressure and the zero-stress state data. Young’s modulus was determined at the contraction threshold. The muscle layer thickness in obstructed intestinal segments increased up to 300%. Compared with sham-obstructed and normal groups, the contraction stress threshold, the maximum contraction stress and the Young’s modulus at the contraction threshold increased whereas the strain threshold and maximum contraction strain decreased after 7 days obstruction (P<0.05 and 0.01). In conclusion, in the partially obstructed intestinal segments, a larger distension force was needed to evoke contraction likely due to tissue remodeling. Higher contraction stresses were produced and the contraction deformation (strain) became smaller.

Zhao, Jingbo; Liao, Donghua; Yang, Jian; Gregersen, Hans

2011-01-01

399

Safety and reliability analysis in a polyvinyl chloride batch process using dynamic simulator-case study: Loss of containment incident  

Microsoft Academic Search

In this paper, a novel methodology in batch plant safety and reliability analysis is proposed using a dynamic simulator. A batch process involving several safety objects (e.g. sensors, controller, valves, etc.) is activated during the operational stage. The performance of the safety objects is evaluated by the dynamic simulation and a fault propagation model is generated. By using the fault

Datu Rizal; Shinichi Tani; Kimitoshi Nishiyama; Kazuhiko Suzuki

2006-01-01

400

1972 preliminary safety analysis report based on a conceptual design of a proposed repository in Kansas  

SciTech Connect

This preliminary safety analysis report is based on a proposed Federal Repository at Lyons, Kansas, for receiving, handling, and depositing radioactive solid wastes in bedded salt during the remainder of this century. The safety analysis applies to a hypothetical site in central Kansas identical to the Lyons site, except that it is free of nearby salt solution-mining operations and bore holes that cannot be plugged to Repository specifications. This PSAR contains much information that also appears in the conceptual design report. Much of the geological-hydrological information was gathered in the Lyons area. This report is organized in 16 sections: considerations leading to the proposed Repository, design requirements and criteria, a description of the Lyons site and its environs, land improvements, support facilities, utilities, different impacts of Repository operations, safety analysis, design confirmation program, operational management, requirements for eventually decommissioning the facility, design criteria for protection from severe natural events, and the proposed program of experimental investigations. (DLC)

Blomeke, J.O.

1977-08-01

401

PWR integrated safety analysis methodology using multi-level coupling algorithm  

NASA Astrophysics Data System (ADS)

Coupled three-dimensional (3D) neutronics/thermal-hydraulic (T-H) system codes give a unique opportunity for a realistic modeling of the plant transients and design basis accidents (DBA) occurring in light water reactors (LWR). Examples of such DBAs are the rod ejection accidents (REA) and the main steam line break (MSLB) that constitute the bounding safety problems for pressurized water reactors (PWR). These accidents involve asymmetric 3D spatial neutronic and T-H effects during the course of the transients. The thermal margins (the peak fuel temperature, and departure from nucleate boiling ratio (DNBR)) are the measures of safety at a particular transient and need to be evaluated as accurate as possible. Modern 3D neutronics/T-H coupled codes estimate the safety margins coarsely on an assembly level, i.e. for an average fuel pin. More accurate prediction of the safety margins requires the evaluation of the transient fuel rod response involving locally coupled neutronics/T-H calculations. The proposed approach is to perform an on-line hot-channel safety analysis not for the whole core but for a selected local region, for example for the highest power loaded fuel assembly. This approach becomes feasible if an on-line algorithm capable to extract the necessary input data for a sub-channel module is available. The necessary input data include the detailed pin-power distributions and the T-H boundary conditions for each sub-channel in the considered problem. Therefore, two potential challenges are faced in the development of refined methodology for evaluation of local safety parameters. One is the development of an efficient transient pin-power reconstruction algorithm with a consistent cross-section modeling. The second is the development of a multi-level coupling algorithm for the T-H boundary and feed-back data exchange between the sub-channel module and the main 3D neutron kinetics/T-H system code, which already uses one level of coupling scheme between 3D neutronics and core thermal-hydraulics models. The major accomplishment of the thesis is the development of an integrated PWR safety analysis methodology with locally refined safety evaluations. This involved introduction of an improved method capable of efficiently restoring the fine pin-power distribution with a high degree of accuracy. In order to apply the methodology to evaluate the safety margins on a pin level, a refined on-line hot channel model was developed accounting for the cross-flow effects. Finally, this methodology was applied to best estimate safety analysis to more accurately calculate the thermal safety margins occurring during a design basis accident in PWR.

Ziabletsev, Dmitri Nickolaevich

402

Analysis of Reed-Solomon coded frequency-hopping systems with non ideal interleaving in worst case partial band jamming  

NASA Astrophysics Data System (ADS)

The interleaving span of coded frequency-hopped systems is often constrained to be smaller than the decoder memory length, i.e., nonideal interleaving is performed. Analysis of the performance of a hard-decision decoder and an erasure-control decoder of Reed-Solomon codes is presented, both for ideal and nonideal interleaving. The interference consists of worst-case partial-band noise jamming and thermal noise. The frequency-hopping system considered uses orthogonal MFSK modulation and noncoherent demodulation with quality bit output based on Viterbi's ratio-threshold technique. Optimization of the ratio-threshold and the erasure-control parameters is performed in worst-case partial-band jamming, and the resulting performance for several interleaver spans is presented.

Laufer, Shaul; Reichman, Arie

403

Assessment of documentation requirements under DOE 5481. 1, Safety Analysis and Review System (SARS)  

SciTech Connect

This report assesses the requirements of DOE Order 5481.1, Safety Analysis and Review System for DOE Operations (SARS) in regard to maintaining SARS documentation. Under SARS, all pertinent details of the entire safety analysis and review process for each DOE operation are to be traceable from the initial identification of a hazard. This report is intended to provide assistance in identifying the points in the SARS cycle at which documentation is required, what type of documentation is most appropriate, and where it ultimately should be maintained.

Browne, E.T.

1981-03-01

404

Safety analysis report for the TRUPACT-II shipping package (condensed version). Volume 1, Rev. 14  

SciTech Connect

The condensed version of the TRUPACT-II Contact Handled Transuranic Waste Safety Analysis Report for Packaging (SARP) contains essential material required by TRUPACT-II users, plus additional contents (payload) information previously submitted to the U.S. Nuclear Regulatory Commission. All or part of the following sections, which are not required by users of the TRUPACT-II, are deleted from the condensed version: (i) structural analysis, (ii) thermal analysis, (iii) containment analysis, (iv) criticality analysis, (v) shielding analysis, and (vi) hypothetical accident test results.

NONE

1994-10-01

405

Safety, tolerability and risk benefit analysis of tiotropium in COPD  

PubMed Central

COPD is a chronic disease and, like many other chronic diseases, there is no treatment to reverse the severity of the disease except for lung transplant. To date, no inhaled medications have been shown to improve survival. Tiotropium bromide is a long-acting inhaled anticholinergic drug for the treatment of COPD that can improve lung function, reduce symptoms and exacerbations, and improve quality of life with once-daily dosing. It was initially approved and marketed in several countries in Europe in 2002 and then approved in the US in 2004. Tiotropium is generally well tolerated with dry mouth being the main adverse effect. Other adverse effects include constipation, tachycardia, blurred vision, urinary retention and increased intraocular pressure. Despite the recently raised concerns about an excess risk of cardiovascular adverse events with inhaled anticholinergic agents, the risk/benefit ratio of tiotropium appears still favorable given the favorable safety profile demonstrated in the UPLIFT study. However, caution should be advised in patients at high risk for cardiovascular disease given the paucity of data in such patients.

Oba, Yuji; Zaza, Tareq; Thameem, Danish M

2008-01-01

406

Phylogenetic analysis of oryx species using partial sequences of mitochondrial rRNA genes.  

PubMed

We conducted a comparative evaluation of 12S rRNA and 16S rRNA genes of the mitochondrial genome for molecular differentiation among three oryx species (Oryx leucoryx, Oryx dammah and Oryx gazella) with respect to two closely related outgroups, addax and roan. Our findings showed the failure of 12S rRNA gene to differentiate between the genus Oryx and addax, whereas a 342-bp partial sequence of 16S rRNA accurately grouped all five taxa studied, suggesting the utility of 16S rRNA segment for molecular phylogeny of oryx at the genus and possibly species levels. PMID:19048493

Khan, H A; Arif, I A; Al Farhan, A H; Al Homaidan, A A

2008-10-28

407

[Partial tonsillectomy].  

PubMed

The feasibility of partial tonsillectomy was reviewed. Compared with total tonsillectomy, partial tonsillectomy has the advantages of less postoperative pain, lower postoperative bleeding rate and faster recovery. Partial tonsillectomy has a potential for tonsil regrowth and its efficacy in treating sleep-disordered breathing in children is still controversial. PMID:24015642

Guo, Pengfei; Li, Jinrang

2013-06-01

408

Costs and benefits of automotive fuel economy improvement: A partial analysis  

SciTech Connect

This paper is an exercise in estimating the costs and benefits of technology-based fuel economy improvements for automobiles and light trucks. Benefits quantified include vehicle cots, fuel savings, consumer`s surplus effects, the effect of reduced weight on vehicle safety, impacts on emissions of CO{sub 2} and criteria pollutants, world oil market and energy security benefits, and the transfer of wealth from US consumes to oil producers. A vehicle stock model is used to capture sales, scrappage, and vehicle use effects under three fuel price scenarios. Three alternative fuel economy levels for 2001 are considered, ranging from 32.9 to 36.5 MPG for cars and 24.2 to 27.5 MPG for light trucks. Fuel economy improvements of this size are probably cost-effective. The size of the benefit, and whether there is a benefit, strongly depends on the financial costs of fuel economy improvement and judgments about the values of energy security, emissions, safety, etc. Three sets of values for eight parameters are used to define the sensitivity of costs and benefits to key assumptions. The net present social value (1989$) of costs and benefits ranges from a cost of $11 billion to a benefit of $286 billion. The critical parameters being the discount rate (10% vs. 3%) and the values attached to externalities. The two largest components are always the direct vehicle costs and fuel savings, but these tend to counterbalance each other for the fuel economy levels examined here. Other components are the wealth transfer, oil cost savings, CO{sub 2} emissions reductions, and energy security benefits. Safety impacts, emissions of criteria pollutants, and consumer`s surplus effects are relatively minor components. The critical issues for automotive fuel economy are therefore: (1) the value of present versus future costs and benefits, (2) the values of external costs and benefits, and (3) the financially cost-effective level of MPG achievable by available technology. 53 refs.

Greene, D.L. [Oak Ridge National Lab., TN (United States); Duleep, K.G. [Energy and Environmental Analysis, Inc., Arlington, VA (United States)

1992-03-01

409

Costs and benefits of automotive fuel economy improvement: A partial analysis  

SciTech Connect

This paper is an exercise in estimating the costs and benefits of technology-based fuel economy improvements for automobiles and light trucks. Benefits quantified include vehicle cots, fuel savings, consumer's surplus effects, the effect of reduced weight on vehicle safety, impacts on emissions of CO{sub 2} and criteria pollutants, world oil market and energy security benefits, and the transfer of wealth from US consumes to oil producers. A vehicle stock model is used to capture sales, scrappage, and vehicle use effects under three fuel price scenarios. Three alternative fuel economy levels for 2001 are considered, ranging from 32.9 to 36.5 MPG for cars and 24.2 to 27.5 MPG for light trucks. Fuel economy improvements of this size are probably cost-effective. The size of the benefit, and whether there is a benefit, strongly depends on the financial costs of fuel economy improvement and judgments about the values of energy security, emissions, safety, etc. Three sets of values for eight parameters are used to define the sensitivity of costs and benefits to key assumptions. The net present social value (1989$) of costs and benefits ranges from a cost of $11 billion to a benefit of $286 billion. The critical parameters being the discount rate (10% vs. 3%) and the values attached to externalities. The two largest components are always the direct vehicle costs and fuel savings, but these tend to counterbalance each other for the fuel economy levels examined here. Other components are the wealth transfer, oil cost savings, CO{sub 2} emissions reductions, and energy security benefits. Safety impacts, emissions of criteria pollutants, and consumer's surplus effects are relatively minor components. The critical issues for automotive fuel economy are therefore: (1) the value of present versus future costs and benefits, (2) the values of external costs and benefits, and (3) the financially cost-effective level of MPG achievable by available technology. 53 refs.

Greene, D.L. (Oak Ridge National Lab., TN (United States)); Duleep, K.G. (Energy and Environmental Analysis, Inc., Arlington, VA (United States))

1992-03-01

410

YUCCA MOUNTAIN SITE CHARACTERIZATIONS PROJECT TUNNEL BORING MACHINE (TBM) SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate hazards related to the tunnel boring machine (TBM) used in the Exploratory Studies Facility (ESF) at the Yucca Mountain Site Characterization Project. This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. Since the TBM is an ''as built'' system, the M&O is conducting the System Safety Analysis during the construction or assembly phase of the TBM. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the TBM in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the system/subsystem/component design, (2) add safety features and capabilities to existing designs, and (3) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions. The scope of this analysis is limited to the TBM during normal operations, excluding hazards occurring during assembly and test of the TBM or maintenance of the TBM equipment.

N /A

1997-02-19

411

Software Safety Analysis of Digital Protection System Requirements Using a Qualitative Formal Method  

SciTech Connect

The safety analysis of requirements is a key problem area in the development of software for the digital protection systems of a nuclear power plant. When specifying requirements for software of the digital protection systems and conducting safety analysis, engineers find that requirements are often known only in qualitative terms and that existing fault-tree analysis techniques provide little guidance on formulating and evaluating potential failure modes. A framework for the requirements engineering process is proposed that consists of a qualitative method for requirements specification, called the qualitative formal method (QFM), and a safety analysis method for the requirements based on causality information, called the causal requirements safety analysis (CRSA). CRSA is a technique that qualitatively evaluates causal relationships between software faults and physical hazards. This technique, extending the qualitative formal method process and utilizing information captured in the state trajectory, provides specific guidelines on how to identify failure modes and the relationship among them. The QFM and CRSA processes are described using shutdown system 2 of the Wolsong nuclear power plants as the digital protection system example.

Lee, Jang-Soo [Korea Atomic Energy Research Institute (Korea, Republic of); Kwon, Kee-Choon [Korea Atomic Energy Research Institute (Korea, Republic of); Cha, Sung-Deok [Korea Advanced Institute of Science and Technology (Korea, Republic of)

2004-08-15

412

Experience in the use of probabilistic safety analysis for the development of safety concepts for commercial high-temperature reactors  

Microsoft Academic Search

Advanced nuclear reactors in the Federal Republic of Germany (FRG) must analogously fulfill the deterministic safety criteria developed for the light water reactor (LWR). In earlier high-temperature reactor (HTR) concepts, the interpretation of this requirement led to exaggerated safety precautions. Efforts are being made in recent HTR concepts to develop a more specific safety concept making use of probabilistic risk

W. Kroger; J. P. Wolters

1986-01-01

413

Experimental and numerical analysis of pressure pulses characteristics in a Francis turbine with partial load  

NASA Astrophysics Data System (ADS)

This study experimentally and numerically investigates the pressure pulses characteristics and unsteady flow behavior in a Francis turbine with partial load. Unsteady wall pressure measurements with partial load condition are performs to investigate thoroughly pressure fields in the spiral case, runner head cover and straight draft tube dynamically. The unsteady Reynolds- averaged Navier-Stokes equations with the k-?based SST turbulence model were used to model the unsteady flow within the entire flow passage of the Francis turbine. The dominate frequency of the predicted pressure pulses at runner inlet agree with the experimental results in the head cover. The influence of the blade passing frequency causes the simulated peak-to-peak amplitudes in the runner inlet to be larger than in the head cover. The measured and predicted pressure pulses at different positions along the runner are comparable. The predicted pressure fluctuations in the draft tube agree well with the experimental results. However the peak-to-peak amplitudes in the spiral case are not as well predicted so the calculation domain and the inlet boundary conditions need to be improved. At the most unstable operating condition, the pulse in the flow passage are due to the rotor-stator interference (RSI) between the runner and the guide vanes, the blade channel vortex in the runner blade passage and the vortex rope in the draft tube. The unsteady flow patterns in the turbine, including the blade channel vortex in the runner and the helical vortex rope in the draft tube, are classified numerically.

Yexiang, X.; Zhengwei, W.; Zongguo, Y.; Jin, Z.

2010-08-01

414

YUCCA MOUNTAIN SITE CHARACTERIZATION PROJECT EAST-WEST DRIFT SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate hazards related to the design of the Yucca Mountain Project Exploratory Studies Facility (ESF) East-West Cross Drift. This analysis builds upon prior ESF System Safety Analyses and incorporates TS Main Drift scenarios, where applicable, into the East-West Drift scenarios. This System Safety Analysis (SSA) focuses on the personnel safety and health hazards associated with the engineered design of the East-West Drift. The analysis also evaluates other aspects of the East-West Drift, including purchased equipment (e.g., scientific mapping platform) or Systems/Structures/Components (SSCs) and out-of-tolerance conditions. In addition to recommending design mitigation features, the analysis identifies the potential need for procedures, training, or Job Safety Analyses (JSAs). The inclusion of this information in the SSA is intended to assist the organization(s) (e.g., constructor, Safety and Health, design) responsible for these aspects of the East-West Drift in evaluating personnel hazards and augment the information developed by these organizations. The SSA is an integral part of the systems engineering process, whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach is used which incorporates operating experiences and recommendations from vendors, the constructor and the operating contractor. The risk assessment in this analysis characterizes the scenarios associated with East-West Drift SSCs in terms of relative risk and includes recommendations for mitigating all identified hazards. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into SSC designs. (2) Add safety features and capabilities to existing designs. (3) Develop procedures and conduct training to increase worker awareness of potential hazards, reduce exposure to hazards, and inform personnel of the actions required to avoid accidents or correct hazardous conditions. This analysis does not consider temporary construction items and, therefore, does not consider hazards associated with temporary construction items. This analysis will be reviewed and updated to reflect new East-West Drift design changes, construction modifications, and ''as built'' documentation of the East-West Drift when completed. A major difference between this analysis and previous ESF SSAs is the inclusion of hazards that arise as a result of non-accident events, (e.g., ''off-normal'' operations, adverse environmental conditions, or ''out-of-tolerance'' conditions). Non-accident events, that were not included in previous ESF SSAs, include environmental and/or toxic hazards such as leaking gases/fluids, off-gassing reactions, and excessive dust, particulates, exhaust fumes, noise, temperature, etc. which could have an adverse health effect on personnel.

NA

1999-06-08

415

Fuzzy-algebra uncertainty analysis for abnormal-environment safety assessment  

SciTech Connect

Many safety (risk) analyses depend on uncertain inputs and on mathematical models chosen from various alternatives, but give fixed results (implying no uncertainty). Conventional uncertainty analyses help, but are also based on assumptions and models, the accuracy of which may be difficult to assure. Some of the models and assumptions that on cursory examination seem reasonable can be misleading. As a result, quantitative assessments, even those accompanied by uncertainty measures, can give unwarranted impressions of accuracy. Since analysis results can be a major contributor to a safety-measure decision process, risk management depends on relating uncertainty to only the information available. The uncertainties due to abnormal environments are even more challenging than those in normal-environment safety assessments, and therefore require an even more cautious approach. A fuzzy algebra analysis is proposed in this report that has the potential to appropriately reflect the information available and portray uncertainties well, especially for abnormal environments.

Cooper, J.A.

1994-01-01

416

A COMPARATIVE ANALYSIS BETWEEN FRANCE AND JAPAN ON LOCAL GOVERNMENTS' INVOLVEMENT IN NUCLEAR SAFETY GOVERNANCE  

NASA Astrophysics Data System (ADS)

This paper shows a comparative analysis between France and Japan on the way of the local governments' involvement in nuclear safety governance through some interviews. In France, a law came into force that requires related local governments to establish "Commision Locale d'Information" (CLI), which means the local governments officially involve in nuclear regulatory activity. Meanwhile, in Japan, related local governments substantially involve in the operation of nuclear facilities through the "safety agreements" in spite of the lack of legal authority. As a result of comparative analysis, we can point out some institutional input from French cases as follows: to clarify the local governments' roles in the nuclear regulation system, to establish the official channels of communication among nuclear utilities, national regulatory authorities and local governments, and to stipulate explicitly the transparency as a purpose of safety regulation.

Sugawara, Shin-Etsu; Shiroyama, Hideaki

417

Using fault analysis methods to improve bioreactor safety.  

PubMed

A simplified fault analysis algorithm has been described and applied to the analysis of containment loss in a model bioreactor system. Using approximate data for component failure rates, the relative merits of three proposed operating regimes were evaluated by means of a computer program that implements the algorithm described. With the data given, operator error is shown to be the dominant cause of possible failure in the proposed system. In view of these results, the simplified algorithm appears useful for the comparative evaluation of various design proposals in simple systems. PMID:3460487

Jefferis, R P; Schlager, S T

1986-01-01

418

Plasma-assisted partial oxidation of methane at low temperatures: numerical analysis of gas-phase chemical mechanism  

NASA Astrophysics Data System (ADS)

Methane partial oxidation was investigated using a plasma microreactor. The experiments were performed at 5 and 300 °C. Microreactor configuration allows an efficient evacuation of the heat generated by methane partial oxidation and dielectric barrier discharges, allowing at the same time a better temperature control. At 5 °C, liquid condensation of low vapour pressure compounds, such as formaldehyde and methanol, occurs. 1H-NMR analysis allowed us to demonstrate significant CH3OOH formation during plasma-assisted partial oxidation of methane. Conversion and product selectivity were discussed for both temperatures. In the second part of this work, a numerical simulation was performed and a gas-phase chemical mechanism was proposed and discussed. From the comparison between the experimental results and the simulation it was found that CH3OO· formation has a determinant role in oxygenated compound production, since its fast formation disfavoured radical recombination. At 5 °C the oxidation leads mainly towards oxygenated compound formation, and plasma dissociation was the major phenomenon responsible for CH4 conversion. At 300 °C, higher CH4 conversion resulted from oxidative reactions induced by ·OH radicals with a chemistry predominantly oxidative, producing CO, H2, CO2 and H2O.

Goujard, Valentin; Nozaki, Tomohiro; Yuzawa, Shuhei; A?iral, Anil; Okazaki, Ken

2011-07-01

419

Applicability of RELAP5 for safety analysis of AP600 and PIUS reactors. [Advanced reactors  

SciTech Connect

An assessment of the applicability of using RELAP5 for performing safety analyses of the AP600 and PIUS advanced reactor concepts is being performed. This ongoing work is part of a larger safety assessment of advanced reactors sponsored by the United States Nuclear Regulatory Commission. RELAP5 models and correlations are being reviewed from the perspective of the new AP600 and PIUS phenomena and features that could be important to reactor safety. The purpose is to identify those areas in which new mathematical models of physical phenomena would be required to be added to RELAP5. In most cases, the AP600 and PIUS designs and systems and the planned and off-normal operations are similar enough to current Pressurized Water Reactors (PWR) that RELAP5 safety analysis applicability is unchanged. However, for AP600 the single most important systemic and phenomenological difference between it and current PWRs is in the close coupling between the reactor system and the containment during postulated Loss of Coolant Accident (LOCA) events. This close coupling may require the addition of some thermal-hydraulic models to RELAP5. And for PIUS, the most important new feature is the thermal density locks. These and other important safety-related features are discussed. This document presents general descriptions of RELAP5, AP600, and PIUS, describes the new features and phenomena of the reactors, and discusses the code/reactors safety-related issues. 32 refs., 4 figs., 2 tabs.

Motloch, C.G.; Modro, S.M.

1990-01-01

420

Multivariate analysis of neuronal interactions in the generalized partial least squares framework: simulations and empirical studies  

Microsoft Academic Search

Identification of spatiotemporal interactions within\\/between neuron populations is critical for detection and characterization of large-scale neuronal interactions underlying perception, cognition, and behavior. Univariate analysis has been employed successfully in many neuroimaging studies. However, univariate analysis does not explicitly test for interactions between distributed areas of activity and is not sensitive to distributed responses across the brain. Multivariate analysis can explicitly

Fa-Hsuan Lin; Anthony R. McIntosh; John A. Agnew; Guinevere F. Eden; Thomas A. Zeffiro; John W. Belliveau

2003-01-01

421

Highway Safety: Law Enforcement; Alcohol; Driver Training; Safety Planning and Management; Commercial Vehicles; and Motorcycles. Transportation Research Record. Journal of the Transportation Research Board, No.1969.  

National Technical Information Service (NTIS)

Partial Contents: Analysis of Speeding in Saudi Arabia and Effectiveness of Enforcement Methods; Reasonable Speed Limits on Suburban Multilane Highways with Curbs; Effect of Red Light Cameras on Accident Risk at Intersections; Safety impacts of Photo-Red ...

2006-01-01

422

Evaluation of a Partial Genome Screening of Two Asthma Susceptibility Regions Using Bayesian Network Based Bayesian Multilevel Analysis of Relevance  

PubMed Central

Genetic studies indicate high number of potential factors related to asthma. Based on earlier linkage analyses we selected the 11q13 and 14q22 asthma susceptibility regions, for which we designed a partial genome screening study using 145 SNPs in 1201 individuals (436 asthmatic children and 765 controls). The results were evaluated with traditional frequentist methods and we applied a new statistical method, called Bayesian network based Bayesian multilevel analysis of relevance (BN-BMLA). This method uses Bayesian network representation to provide detailed characterization of the relevance of factors, such as joint significance, the type of dependency, and multi-target aspects. We estimated posteriors for these relations within the Bayesian statistical framework, in order to estimate the posteriors whether a variable is directly relevant or its association is only mediated. With frequentist methods one SNP (rs3751464 in the FRMD6 gene) provided evidence for an association with asthma (OR?=?1.43(1.2–1.8); p?=?3×10?4). The possible role of the FRMD6 gene in asthma was also confirmed in an animal model and human asthmatics. In the BN-BMLA analysis altogether 5 SNPs in 4 genes were found relevant in connection with asthma phenotype: PRPF19 on chromosome 11, and FRMD6, PTGER2 and PTGDR on chromosome 14. In a subsequent step a partial dataset containing rhinitis and further clinical parameters was used, which allowed the analysis of relevance of SNPs for asthma and multiple targets. These analyses suggested that SNPs in the AHNAK and MS4A2 genes were indirectly associated with asthma. This paper indicates that BN-BMLA explores the relevant factors more comprehensively than traditional statistical methods and extends the scope of strong relevance based methods to include partial relevance, global characterization of relevance and multi-target relevance.

Antal, Peter; Kiszel, Petra Sz.; Gezsi, Andras; Hadadi, Eva; Virag, Viktor; Hajos, Gergely; Millinghoffer, Andras; Nagy, Adrienne; Kiss, Andras; Semsei, Agnes F.; Temesi, Gergely; Melegh, Bela; Kisfali, Peter; Szell, Marta; Bikov, Andras; Galffy, Gabriella; Tamasi, Lilla; Falus, Andras; Szalai, Csaba

2012-01-01

423

Waste sampling and characterization facility complex safety analysis  

SciTech Connect

The Waste Sampling and Characterization Facility is a `Non-Nuclear, Radiological Facility. This document demonstrates, by analysis, that WSCF can meet the chemical and radiological inventory limits for a radiological facility. It establishes control that ensures those inventories are maintained below threshold values to preserve the `Non- Nuclear, Radiological` classification.

Meloy, R.T., Westinghouse Hanford

1996-06-04

424

Mining Safety Signals in Spontaneous Reports Database Using Concept Analysis  

Microsoft Academic Search

In pharmacovigilance, linking the adverse reactions by pa- tients to drugs they took is a key activity typically based on the analysis of patient reports. Yet generating potentially interesting pairs (drug, re- action) from a record database is a complex task, especially when many drugs are involved. To limit the generation eort, we exploit the fre- quently occurring patterns in

Mohamed Rouane Hacene; Yannick Toussaint; Petko Valtchev

2009-01-01

425

Statistical analysis of liquid seepage in partially saturated heterogeneous fracture systems  

SciTech Connect

Field evidence suggests that water flow in unsaturated fracture systems may occur along fast preferential flow paths. However, conventional macroscale continuum approaches generally predict the downward migration of water as a spatially uniform wetting front subjected to strong inhibition into the partially saturated rock matrix. One possible cause of this discrepancy may be the spatially random geometry of the fracture surfaces, and hence, the irregular fracture aperture. Therefore, a numerical model was developed in this study to investigate the effects of geometric features of natural rock fractures on liquid seepage and solute transport in 2-D planar fractures under isothermal, partially saturated conditions. The fractures were conceptualized as 2-D heterogeneous porous media that are characterized by their spatially correlated permeability fields. A statistical simulator, which uses a simulated annealing (SA) algorithm, was employed to generate synthetic permeability fields. Hypothesized geometric features that are expected to be relevant for seepage behavior, such as spatially correlated asperity contacts, were considered in the SA algorithm. Most importantly, a new perturbation mechanism for SA was developed in order to consider specifically the spatial correlation near conditioning asperity contacts. Numerical simulations of fluid flow and solute transport were then performed in these synthetic fractures by the flow simulator TOUGH2, assuming that the effects of matrix permeability, gas phase pressure, capillary/permeability hysteresis, and molecular diffusion can be neglected. Results of flow simulation showed that liquid seepage in partially saturated fractures is characterized by localized preferential flow, along with bypassing, funneling, and localized ponding. Seepage pattern is dominated by the fraction of asperity contracts, and their shape, size, and spatial correlation. However, the correlation structure of permeability field is less important than the spatial correlation of asperity contacts. A faster breakthrough was observed in fractures subjected to higher normal stress, accompanied with a nonlinearly decreasing trend of the effective permeability. Interestingly, seepage dispersion is generally higher in fractures with intermediate fraction of asperity contacts; but it is lower for small or large fractions of asperity contacts. However, it may become higher if the ponding becomes significant. Transport simulations indicate that tracers bypass dead-end pores and travel along flow paths that have less flow resistance. Accordingly, tracer breakthrough curves generally show more spreading than breakthrough curves for water. Further analyses suggest that the log-normal time model generally fails to fit the breakthrough curves for water, but it is a good approximation for breakthrough curves for the tracer.

Liou, T.S.

1999-12-01

426

Electronic Nose Based on Independent Component Analysis Combined with Partial Least Squares and Artificial Neural Networks for Wine Prediction  

PubMed Central

The aim of this work is to propose an alternative way for wine classification and prediction based on an electronic nose (e-nose) combined with Independent Component Analysis (ICA) as a dimensionality reduction technique, Partial Least Squares (PLS) to predict sensorial descriptors and Artificial Neural Networks (ANNs) for classification purpose. A total of 26 wines from different regions, varieties and elaboration processes have been analyzed with an e-nose and tasted by a sensory panel. Successful results have been obtained in most cases for prediction and classification.

Aguilera, Teodoro; Lozano, Jesus; Paredes, Jose A.; Alvarez, Fernando J.; Suarez, Jose I.

2012-01-01

427

Calibration of a neutron log in partially saturated media. Part II. Error analysis  

SciTech Connect

Four sources or error (uncertainty) are studied in water content obtained from neutron logs calibrated in partially saturated media for holes up to 3 m. For this calibration a special facility was built and an algorithm for a commercial epithermal neutron log was developed that obtains water content from count rate, bulk density, and gap between the neutron sonde and the borehole wall. The algorithm contained errors due to the calibration and lack of fit, while the field measurements included uncertainties in the count rate (caused by statistics and a short time constant), gap, and density. There can be inhomogeneity in the material surrounding the borehole. Under normal field conditions the hole-size-corrected water content obtained from such neutron logs can have an uncertainty as large as 15% of its value.

Hearst, J.R.; Kasameyer, P.W.; Dreiling, L.A.

1981-03-20

428

Analysis of heat and fluid flow in partially divided fluid saturated porous cavities  

NASA Astrophysics Data System (ADS)

Fluid flow and heat transfer phenomena in partially divided cavities filled with porous media have been numerically studied in this research. A non-Darcy generalized formulation is applied to describe the behavior of fluid flow in porous media. A splitting semi-implicit finite element method is adopted to solve the governing equations. The range of Ra involved in this study is between 104 and 106. Three different locations of dividers are investigated to probe the geometrical effect on heat and fluid flow. The results of Da = 10-2 display a trend similar to the non-porous medium, but those of Da = 10-4 show dramatic decrease in flow strength, as well as heat transfer rate. A different location of divider may change the local and average Nusselt numbers.

Jue, T. C.

429

Analysis and simulation of a fiber bundle method for creating a partially spatially coherent beam.  

PubMed

A fiber bundle arrangement containing a distribution of fiber lengths has been proposed in the literature to produce a partially spatially coherent beam. Light input to the bundle with limited temporal coherence is translated into limited spatial coherence. Expressions are developed for the bundle pupil autocorrelation function and far-field irradiance pattern. A numerical simulation approach is implemented and results are compared with a speckle-free result. The fiber bundle approach tends to create an irradiance pattern whose average shape matches the pattern produced by a single fiber. A "smoothed" far-field pattern is obtained if the fiber length difference is much greater than the source temporal coherence length. PMID:23938434

Xiao, Xifeng; Voelz, David

2013-08-10

430

Comparative Analysis of Different Configurations of PLC-Based Safety Systems from Reliability Point of View.  

National Technical Information Service (NTIS)

The study of a comparative analysis of distinct multiplex and fault-tolerant configurations for a PLC-based safety system from a reliability point of view is presented. It considers simplex, duplex and fault-tolerant triple redundancy configurations. The ...

M. A. Tapia

1993-01-01

431

Safety of railway control systems: A new Preliminary risk analysis approach  

Microsoft Academic Search

Preliminary risk analysis (PRA) is a methodology used in critical systems safety studies. It is primarily used at the preliminary stage of the system¿s design so as to determine the scenarios of potential accidents, to evaluate their probabilities of occurrence (frequency) as well as the severity of the resulting consequences and to propose solutions (preventive and\\/or mitigative safeguards) in order

F. Guenab; J. L. Boulanger; W. Schon

2008-01-01

432

Breach and safety analysis of spills over water from large liquefied natural gas carriers  

Microsoft Academic Search

In 2004, at the request of the Department of Energy, Sandia National Laboratories (Sandia) prepared a report, ''Guidance on the Risk and Safety Analysis of Large Liquefied Natural Gas (LNG) Spills Over Water''. That report provided framework for assessing hazards and identifying approaches to minimize the consequences to people and property from an LNG spill over water. The report also

Marion Michael Hightower; Anay Josephine Luketa-Hanlin; Stephen W. Attaway

2008-01-01

433

Dynamic fault tree analysis using Monte Carlo simulation in probabilistic safety assessment  

Microsoft Academic Search

Traditional fault tree (FT) analysis is widely used for reliability and safety assessment of complex and critical engineering systems. The behavior of components of complex systems and their interactions such as sequence- and functional-dependent failures, spares and dynamic redundancy management, and priority of failure events cannot be adequately captured by traditional FTs. Dynamic fault tree (DFT) extend traditional FT by

K. Durga Rao; V. Gopika; V. V. S. Sanyasi Rao; H. S. Kushwaha; A. K. Verma; A. Srividya

2009-01-01

434

Quantitative and Qualitative Analysis of Nutrition and Food Safety Information in School Science Textbooks of India  

ERIC Educational Resources Information Center

|Objective: To assess quantity and quality of nutrition and food safety information in science textbooks prescribed by the Central Board of Secondary Education (CBSE), India for grades I through X. Design: Content analysis. Methods: A coding scheme was developed for quantitative and qualitative analyses. Two investigators independently coded the…

Subba Rao, G. M.; Vijayapushapm, T.; Venkaiah, K.; Pavarala, V.

2012-01-01

435

Finite element analysis of impact damage response of composite motorcycle safety helmets  

Microsoft Academic Search

The energy absorption during impact provided by a motorcycle safety helmet is always of critical importance in order to protect the rider against head injury during an accident. In the present study, a parametric analysis has been performed in order to investigate the effect of the composite shell stiffness and the damage development during impact, on the dynamic response of

V Kostopoulos; Y. P Markopoulos; G Giannopoulos; D. E Vlachos

2002-01-01

436

Advanced Test Reactor Critical Facility safety analysis report five year currency review. Revision 1.  

National Technical Information Service (NTIS)

By DOE-ID Order 5481.1A, a five year currency review is required of the Safety Analysis Reports of all ID or ID contractor operations having hazards of a type and magnitude not routinely encountered and/or accepted by the public. In keeping with this orde...

P. R. Napper W. R. Carpenter R. W. Garner

1991-01-01

437

Frequency Agile Laser Safety & Hazard Analysis for the Sandia Remote Sensing System LIDAR.  

National Technical Information Service (NTIS)

A laser safety and hazard analysis was performed for the Raytheon Frequency Agile Laser (FAL) to be used with the Sandia Remote Sensing System (SRSS) B-70 Trailer based on the 2007 version of the American National Standards Institute's (ANSI) Standard 136...

A. L. Augustoni

2009-01-01

438

Preliminary Accident Analysis for Construction and Operation of the Chornobyl New Safety Confinement  

SciTech Connect

Analysis of potential exposure of personal and population during construction and exploitation of the New Safe Confinement was made. Scenarios of hazard event development were ranked. It is shown, that as a whole construction and exploitation of the NSC are in accordance with actual radiation safety norms of Ukraine.

Batiy, Valeriy; Rubezhansky, Yruiy; Rudko, Vladimir; shcherbin, vladimir; Yegorov, V; Schmieman, Eric A.; Timmins, Douglas C.

2005-08-08

439

Mechanical engineering note - safety analysis of molten uranium\\/water interaction in the uranium foundry furnace  

Microsoft Academic Search

This Engineering Note describes the development of the accident criteria used the basis for the design of the uranium foundry vacuum vessel. The results of this analysis provide input into other safety notes that investigate how well the uranium containment boundary will maintain its integrity during the design basis accident. The preventative measures that have been designed into the system

W H Gourdin; J Sze

1999-01-01

440

Reactor Containment Dependability Analysis in Safety Critical Nuclear Power Plants: Design, Implementation and Experience  

Microsoft Academic Search

The use of nuclear energy to generate electric power is crucial in meeting the high energy demand of modern economy. The dependability analysis of nuclear power plants has been a critical issue and the reactor containment is the most important safety structure acting as a barrier against the release of radioactive material to the environment. In this paper, we analyze

Chi-Shiang Cho; Wei-Ho Chung; Deyun Gao; Hongke Zhang; Sy-Yen Kuo

2011-01-01

441

Multi-criteria risk analysis to improve safety in manufacturing systems  

Microsoft Academic Search

The drive to lower operating costs and improve manufacturing efficiency has led many manufacturing companies to implement different methodologies in order to identify a suitable risk assessment model. So, the concern for safety in industrial activities, both inside the establishments and in their surroundings, has a crucial role. As a result, many laws, regulations and risk analysis techniques are well

Alessandro Silvestri; Fabio De Felice; Antonella Petrillo

2012-01-01

442

Safety analysis report upgrade program at the Plutonium Facility, Los Alamos National Laboratory  

Microsoft Academic Search

Plutonium research and development activities have resided at the Los Alamos National Laboratory (LANL) since 1943. The function of the Plutonium Facility (PF-4) has been to perform basic special nuclear materials research and development and to support national defense and energy programs. The original Final Safety Analysis Report (FSAR) for PF-4 was approved by DOE in 1978. This FSAR analyzed

1993-01-01

443

Proposed Outline of Safety Analysis Report for Facilities for Geologic Isolation of Radioactive Wastes.  

National Technical Information Service (NTIS)

This report is concerned with formulating the appropriate and necessary contents for a Safety Analysis Report (SAR) for safe, long-term radioactive waste isolation in federal repositories. The material is presented as a guide rather than as an outline of ...

L. W. Weisbecker L. L. Gerchman B. R. Holt S. J. Mara S. L. McHugh

1977-01-01

444

An integrated safety-analysis methodology for emerging air-transport technologies  

Microsoft Academic Search

We demonstrate an approach to integrating reliability, performance, and operational procedures modeling into a system safety analysis. Our methodology is distinguished by its ability to merge system design information with the dynamic parameterization of a system's situation in order to measure accident statistics and reliable system operation. As an application of this methodology, we have considered the problem of simultaneous,

Deborah F. Allinger; G. Rosch; J. K. Kuchar

1998-01-01

445

Systems Safety: Practical Evaluation of Sneak Circuit Analysis Applied to Case Studies.  

National Technical Information Service (NTIS)

The main benefits and questions arising from the application of sneak circuit analysis methods to systems safety studies are discussed. To assess the method, CNES, DGA and ESA gathered to get three case studies performed by Alcatel Espace and Matra Espace...

P. Charon J. M. Jeandupeux A. Lehenaff J. Mignot O. Nicolas

1991-01-01

446

Computing what the public wants: Some issues in road safety cost–benefit analysis  

Microsoft Academic Search

In road safety, as in other fields, cost–benefit analysis (CBA) is used to justify the investment of public money and to establish priority between projects. It amounts to a computation by which ‘few’ – the CB analysts – aim to determine what the ‘many’ – those on behalf of which the choice is to be made – would choose. The

Ezra Hauer

2011-01-01

447

Simulation of Accidental UF sub 6 Releases in Support of the Safety Analysis Effort.  

National Technical Information Service (NTIS)

The safety analysis of the US uranium enrichment facilities requires that postulated accidental releases of UF sub 6 be simulated. In order to predict the human health consequences of a postulated UF sub 6 release, two types of information are needed: (1)...

R. A. Just

1986-01-01

448

Dynamic Partial Evaluation  

Microsoft Academic Search

Dynamic partial evaluation performs partial evaluation as a side effect of evaluation, with no previous static analysis required.\\u000a A completely dynamic version of partial evaluation is not merely of theoretical interest, but has practical applications,\\u000a especially when applied to dynamic, reflective programming languages. Computational reflection, and in particular the use\\u000a of meta-object protocols (MOPs), provides a powerful abstraction mechanism, providing

Gregory T. Sullivan

2001-01-01

449

Safety Analysis and Performance Evaluation of Time WF-nets  

Microsoft Academic Search

Time management in workflow systems is crucial in determining and controlling the life cycle of a workflow process. Research\\u000a on time modeling and analysis is important to guarantee workflow plans to be efficiently implemented and to make enterprises\\u000a more competitive. Time WF-nets derived from time Petri nets and WF-nets are an effective model for workflow time management.\\u000a In this paper,

Wei Song; Wan-chun Dou; Jinjun Chen; Shaokun Fan

2007-01-01

450

Safety analysis of an accelerator-driven test facility  

Microsoft Academic Search

One of the milestones in the roadmap of accelerator-driven transmutation of waste (ATW) of the U.S. Department of Energy is the design and construction of an accelerator-driven test facility (ADTF) with a thermal power of 100MW. Analysis of the dynamic behavior of the ADTF has been carried out in the frame of a bilateral collaboration between the Forschungszentrum Karlsruhe and

X. Cheng; J. E. Cahalan; P. J. Finck

2004-01-01

451

Top-Off Safety Analysis for NSLS-II  

SciTech Connect

Top-off injection will be adopted in NSLS-II. To ensure no injected beam can pass into experimental beamlines with open photon shutters during top-off injection, simulation studies for possible machine fault scenarios are required. We compare two available simulation methods, backward (H. Nishimura-LBL) and forward tracking (A. Terebilo-SLAC). We also discuss the tracking settings, fault scenarios, apertures and interlocks considered in the analysis.

Li,Y.; Casey, B.; Heese, R.; Hseuh, H.; Job, O.; Krinsky, S.; Parker, B.; Shaftan, T.; Sharma, S.

2009-05-04

452

Safety Analysis of Ada Programs Using Fault Trees  

Microsoft Academic Search

Software is increasingly being used in the control of potentially hazardous systems. Software fault-tree analysis is a technique for analyzing the logic of software for any potential contribution to system mishaps. The technique is described using Ada as an example real-time language. Special consideration is given to the problems of concurrency and real-time constraints which are common in these types

Nancy G. Leveson; Janice L. Stolzy

1983-01-01

453

SYSTEMS SAFETY ANALYSIS FOR FIRE EVENTS ASSOCIATED WITH THE ECRB CROSS DRIFT  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate fire hazards related to the Yucca Mountain Site Characterization Project (YMP) Enhanced Characterization of the Repository Block (ECRB) East-West Cross Drift (commonly referred to as the ECRB Cross-Drift). This analysis builds upon prior Exploratory Studies Facility (ESF) System Safety Analyses and incorporates Topopah Springs (TS) Main Drift fire scenarios and ECRB Cross-Drift fire scenarios. Accident scenarios involving the fires in the Main Drift and the ECRB Cross-Drift were previously evaluated in ''Topopah Springs Main Drift System Safety Analysis'' (CRWMS M&O 1995) and the ''Yucca Mountain Site Characterization Project East-West Drift System Safety Analysis'' (CRWMS M&O 1998). In addition to listing required mitigation/control features, this analysis identifies the potential need for procedures and training as part of defense-in-depth mitigation/control features. The inclusion of this information in the System Safety Analysis (SSA) is intended to assist the organization(s) (e.g., Construction, Environmental Safety and Health, Design) responsible for these aspects of the ECRB Cross-Drift in developing mitigation/control features for fire events, including Emergency Refuge Station(s). This SSA was prepared, in part, in response to Condition/Issue Identification and Reporting/Resolution System (CIRS) item 1966. The SSA is an integral part of the systems engineering process, whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach is used which incorporates operating experiences and recommendations from vendors, the constructor and the operating contractor. The risk assessment in this analysis characterizes the scenarios associated with fires in terms of relative risk and includes recommendations for mitigating all identified hazards. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into Structure, System, or Component (SSC) designs; (2) Add safety features and capabilities to existing designs; and (3) Develop procedures and conduct training to increase worker awareness of potential hazards, reduce exposure to hazards, and inform personnel of the actions required to avoid accidents or correct hazardous conditions.

R. J. Garrett

2001-12-12

454

Experimental analysis of the levees safety based on geophysical monitoring  

NASA Astrophysics Data System (ADS)

Several flood events brought river levees into the focus of attention for some disasters due to their collapse. This phenomena is quite complex to investigate, because of different factors that can affect the stability of levees, among them the non uniformity of material properties, which influencing the permeability of the embankment, might induce high percolation velocity of flux thus triggering the unstability. Thus, to apply a fast and integrate investigation methods with a non-destructive characteristics should have a large interest, if they are able to furnish ready and usable information necessary to hydrogeological models. In order to achieve this goal, the University of Perugia (Department of Civil and Environmental Engineering) and the National Research Council (IRPI and IMAA research institutes) developed a collaborating project on the study of the internal structure of the river embankment by carrying out experiments in laboratory. The purpose of this study is to show the preliminary results of the experimental investigation. The laboratory embankment was built using material coming from a real levee and gathered inside a 1.5m x 1.2m plexiglas box. The box has two compartments: a water reservoir at one hand where a constant water head was reached after some time and a soil simulating the presence of levee. We perform a geoelectrical multichannel acquisition system with three parallel profiles characterized by 16 mini-electrodes connected to georesistivimeter Syscal Pro. An automatic acquisition protocol has been performed to obtain time slice electrical tomographies during the experiments. The geophysical results show the effect of the water table inside the embankment during the wetting and emptying. In order to assess the capability of the geophysical monitoring for addressing the soil parameters estimate, the resistivity results are investigated by using two analytical and one hydraulic numerical models. The analytical models represent a linear solution of Laplace's equation where Dupuit hypothesis holds (the vertical gradients of the flow velocity in the medium are neglected). In particular, the Marchi and Supino solutions are investigated here by assuming the upstream water level variations in the river negligible with respect to the ones inside the groundwater under the steady state condition. Two different seepage fronts are calculated and compared with the ones inferred from the resistivity maps. The experimental data have been also compared with the results computed by a numerical code. The governing equation for the unsaturated-saturated medium is the continuity equation written in terms of the piezometric head unknown while the Brooks-Corey law relates the water content and the relative hydraulic conductivity to the piezometric head. The numerical model is a time splitting technique and the solution is obtained by solving consecutively a convective and a diffusive component. The medium has been discretized in space using a generally unstructured triangular mesh. The governing equations are discretized using the edge centred mixed hybrid finite element scheme. The computational domain is schematized as 1D network of cells located at the middle point of each edge and linked by fictitious channels and the storage capacity is concentrated in the cells. A linear variation of unknown is assumed inside each triangle. The positive outcomes of hydraulic model application have certainly had benefit from the information coming from the geophysical monitoring. Based on these preliminary results it was noticeable as the geophysical monitoring can be conveniently adopted for addressing the levee safety control and to provide information on soil parameters.

Rizzo, Enzo; Valeria, Giampaolo; Mario, Votta; Lapenna, Vincenzo; Moramarco, Tommaso; Aricò, Costanza; Camici, S.; Morbidelli, Renato; Sinagra, M.; Tucciarelli, T.

2010-05-01

455

A first approach to the safety analysis of a tokamak test reactor by a system study methodology  

Microsoft Academic Search

The safety analysis and risk assessment of a Tokamak Test Reactor is approached by an iterative, probabilistic, system study methodology, jointly developed by ENEA and CEA. The first part of this methodology consists of a safety related functional analysis of the plant. That is developed in a quite systematic and exhaustive way, aiming at the identification of all the process

A. Boschi; T. Palma; S. Sarto; G. Cambi; G. Zappellini; H. Djerassi; J. Rouillard

1989-01-01

456

Comprehensive safety analysis code system for nuclear fusion reactors II: Thermal analysis during plasma disruptions for international thermonuclear experimental reactor  

Microsoft Academic Search

Thermal characteristics of a fusion reactor [International Thermonuclear Experimental Reactor (ITER) Conceptual Design Activity] during plasma disruptions have been analyzed by using a comprehensive safety analysis code for nuclear fusion reactors. The erosion depth due to disruptions for the armor of the first wall depends on the current quench time of disruptions occurring in normal operation. If it is possible

T. Honda; K. Maki; T. Okazaki

1994-01-01

457

Preparation of Phased and Merged Safety Analysis Reports for New DOE Nuclear Facilities  

SciTech Connect

The Spent Nuclear Fuels Project (SNFP) is charged with moving to storage 2,100 metric tons of spent nuclear fuel elements left over from plutonium production at DOE'S Hanford site in Washington state. Two new facilities, the Cold Vacuum Drying Facility (CVDF) and the Canister Storage Building (CSB) are in final construction. In order to meet aggressive schedule commitments, the SNFP chose to prepare the safety analysis reports (SAR's) in phases that covered only specific portions of each facility's design as it was built. Each SAR also merged the preliminary and final safety analysis reports into a single SAR, thereby covering all aspects of design, construction, and operation for that portion (phase) of the facility. A policy of ''NRC equivalency'' was also implemented in parallel with this effort, with the goal of achieving a rigor of safety analysis equivalent to that of NRC-licensed fuel processing facilities. DOE Order 5480.23. ''Nuclear Safety Analysis Reports'' allows preparation of both a phased and a merged SAR to accelerate construction schedules. However, project managers must be aware that such acceleration is not guaranteed. Managers considering this approach for their project should be cognizant of numerous obstacles that will be encountered. Merging and phasing SAR's will create new, unique, and unanticipated difficulties which may actually slow construction unless expeditiously and correctly managed. Pitfalls to be avoided and good practices to be implemented in preparing phased and merged SAR's are presented. The value of applying NRC requirements to the DOE safety analysis process is also discussed. As of December, 1999, the SNFP has completed and approved a SAR for the CVDF. Approval of the SAR for the CSB is pending.

BISHOP, G.E.

2000-04-04

458

Optimization of coupled multiphysics methodology for safety analysis of pebble bed modular reactor  

Microsoft Academic Search

The research conducted within the framework of this PhD thesis is devoted to the high-fidelity multi-physics (based on neutronics\\/thermal-hydraulics coupling) analysis of Pebble Bed Modular Reactor (PBMR), which is a High Temperature Reactor (HTR). The Next Generation Nuclear Plant (NGNP) will be a HTR design. The core design and safety analysis methods are considerably less developed and mature for HTR

Peter Tshepo Mkhabela

2010-01-01

459

Safety level of damaged RoPax ships: Risk modelling and cost-effectiveness analysis  

Microsoft Academic Search

This paper elaborates on results of a recent risk analysis study for RoPax vessels, carried out as part of the activities of the SAFEDOR Integrated Project, targeting possible improvements on safety levels following large scale flooding. The study is based on a comprehensive analysis of accident statistics for the period 1994–2004, through which a high-level risk model (in the form

Luis Guarin; Dimitris Konovessis; Dracos Vassalos

2009-01-01

460

Reactor Accident Analysis Methodology for the Advanced Test Reactor Critical Facility Documented Safety Analysis Upgrade  

Microsoft Academic Search

The regulatory requirement to develop an upgraded safety basis for a DOE Nuclear Facility was realized in January 2001 by issuance of a revision to Title 10 of the Code of Federal Regulations Section 830 (10 CFR 830). Subpart B of 10 CFR 830, ''Safety Basis Requirements,'' requires a contractor responsible for a DOE Hazard Category 1, 2, or 3

G. L. Sharp; R. T. McCracken

2003-01-01

461

Laboratory conditions and safety in a chemical warfare agent analysis and research laboratory.  

PubMed

Toxic chemicals have been used as weapons of war and also as means of terrorist attacks on civilian populations. Research focusing on chemical warfare agents (CWAs) may be associated with an increased risk of exposure to and contamination by these agents. This article summarizes some of the regulations concerning designation and safety in a CWA analysis and research laboratory and medical countermeasures in case of an accidental exposure. The design of such a laboratory, coupled with a set of safety guidelines, provides for the safe conduct of research and studies involving CWAs. Thus, a discussion of decontamination and protection means against CWAs is also presented. PMID:12188231

Kenar, Levent; Karayilano?lu, Turan; Kose, Songul

2002-08-01

462

Augmentation of antipsychotic drug action by azapirone 5-HT1A receptor partial agonists: a meta-analysis.  

PubMed

The aim of the study was to evaluate the evidence that serotonin1A (5-HT1A) receptor partial agonists of the azapirone class, which are not antipsychotic, have benefits for adjunctive treatment of overall psychopathology, positive and negative symptoms for patients with schizophrenia. We carried out a systematic review of the literature available through PubMed, Cochrane Library, PsycINFO and Google Scholar during September 2012, followed by a meta-analysis of randomized placebo-controlled trials. Risk ratio (RR), 95% confidence intervals (CI) and standardized mean difference (s.m.d.) were calculated. Four studies, involving 163 patients with schizophrenia, met inclusion criteria: buspirone: three trials and 137 patients; tandospirone: one trial and 26 patients. As adjunctive therapy, 5-HT1A partial agonists were significantly superior to placebo for overall improvement in psychopathology (s.m.d. = -0.46, CI = -0.79 to -0.13, p = 0.006, N = 4, n = 149) and marginally more effective to improve positive symptoms (s.m.d. = -0.31, CI = -0.64 to 0.01, p = 0.06, N = 4, n = 149). However, 5-HT1A partial agonists were not more efficacious than placebo as adjunctive therapy for improving negative symptoms (s.m.d. = -0.09, CI = -0.60 to 0.42, p = 0.72, N = 4, n = 149). In addition, there was no significant difference in discontinuation rates between 5-HT1A partial agonists and placebo (all cause: RR = 0.98, CI = 0.49-1.98, p = 0.96, N = 4, n = 153, side-effects: RR = 1.96, CI = 0.54-7.19, p = 0.31, N = 4, n = 153). 5-HT1A partial agonists as adjunctive therapy improved overall psychopathology with a trend to improve positive symptoms in patients with schizophrenia. Because the number of studies was small, additional controlled clinical trials with larger numbers of patients are indicated. PMID:23551924

Kishi, Taro; Meltzer, Herbert Y; Iwata, Nakao

2013-04-03