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1

Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (?)-Epicatechin in healthy volunteers  

PubMed Central

(?)-Epicatechin ((?)-EPI), a naturally occurring flavanol has emerged as a likely candidate for cocoa-based product reported reductions in cardiometabolic risk. The present study aimed to determine the safety, tolerability, pharmacokinetics and pharmacodynamics of purified (?)-EPI administered to healthy volunteers. In this phase I, open-label, two-part single- and multiple-dose study subjects received either a single dose (n=9) of 50, 100 or 200 mg or multiple doses (n=8) of 50 mg daily (q.d.) or twice daily (b.i.d) for 5 days. Blood was collected at 0, 0.5, 1, 2, 4 and 6 hrs after (?)-EPI administration in the single and multiple dose groups (blood collection repeated in day 5). Samples were analyzed by HPLC-HR-ESI-MS for EPI and metabolites quantification. In the q.d. and b.i.d. groups, blood samples were analyzed for NO surrogates, follistatin, platelet mitochondrial complex I, V and citrate synthase level determinations. (?)-EPI was well tolerated and readily absorbed with further phase 2 metabolism. On day 5, in the q.d. and b.i.d. groups, there were significant increases in plasma nitrite of 30 % and 17 %, respectively. In the q.d. group on day 5 vs. day 1, platelet mitochondria complexes I, IV and citrate synthase activities demonstrated a significant increase of ~ 92, 62 and 8 %, respectively. Average day 5 follistatin AUC levels were ~2.5 fold higher vs. day 1 AUC levels in the b.i.d. group. (?)-EPI was safe with no observed adverse effects and our findings suggest that increases in NO metabolites, mitochondrial enzyme function and plasma follistatin levels may underlie some of the beneficial effects of cocoa products or (?)-EPI as reported in other studies. PMID:25598082

Barnett, Christopher F.; Moreno-Ulloa, Aldo; Shiva, Sruti; Ramirez-Sanchez, Israel; Taub, Pam R.; Su, Yongxuan; Ceballos, Guillermo; Dugar, Sundeep; Schreiner, George; Villarreal, Francisco

2015-01-01

2

Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers.  

PubMed

(-)-Epicatechin ((-)-EPI), a naturally occurring flavanol, has emerged as a likely candidate for cocoa-based product reported reductions in cardiometabolic risk. The present study aimed to determine the safety, tolerability, pharmacokinetics and pharmacodynamics of purified (-)-EPI administered to healthy volunteers. In this phase I, open-label, two-part single- and multiple-dose study, subjects received either a single dose (n = 9) of 50, 100 or 200 mg or multiple doses (n = 8) of 50 mg daily (q.d.) or twice daily (b.i.d) for 5 days. Blood was collected at 0, 0.5, 1, 2, 4 and 6 h after (-)-EPI administration in the single and multiple dose groups (blood collection repeated in day 5). Samples were analyzed by HPLC-HR-ESI-MS for EPI and metabolite quantification. In the q.d. and b.i.d. groups, blood samples were analyzed for NO surrogates and follistatin levels as well as, platelet mitochondrial complexes I, V and citrate synthase activity levels. (-)-EPI was well tolerated and readily absorbed with further phase 2 metabolism. On day 5, in the q.d. and b.i.d. groups, there were significant increases in plasma nitrite of 30% and 17%, respectively. In the q.d. group on day 5 vs. day 1, platelet mitochondrial complexes I, IV and citrate synthase activities demonstrated a significant increase of ?92, 62 and 8%, respectively. Average day 5 follistatin AUC levels were ?2.5 fold higher vs. day 1 AUC levels in the b.i.d. group. (-)-EPI was safe to use, with no observed adverse effects, and our findings suggest that increases in NO metabolites, mitochondrial enzyme function and plasma follistatin levels may underlie some of the beneficial effects of cocoa products or (-)-EPI as reported in other studies. PMID:25598082

Barnett, Christopher F; Moreno-Ulloa, Aldo; Shiva, Sruti; Ramirez-Sanchez, Israel; Taub, Pam R; Su, Yongxuan; Ceballos, Guillermo; Dugar, Sundeep; Schreiner, George; Villarreal, Francisco

2015-03-11

3

Partial Differential Equation Analysis in  

E-print Network

Partial Differential Equation Analysis in Biomedical Engineering PartialDifferentialEquationAnalysisin BiomedicalEngineering Partial Differential Equation Analysis in Biomedical Engineering Case Studies of multi-variable calculus, this introduction to computer-based partial differential equation (PDE

Gilchrist, James F.

4

Safety analysis  

NASA Technical Reports Server (NTRS)

We are engaged in a research program in safety-critical computing that is based on two case studies. We use these case studies to provide application-specific details of the various research issues, and as targets for evaluation of research ideas. The first case study is the Magnetic Stereotaxis System (MSS), an investigational device for performing human neurosurgery being developed in a joint effort between the Department of Physics at the University of Virginia and the Department of Neurosurgery at the University of Iowa. The system operates by manipulating a small permanent magnet (known as a 'seed') within the brain using an externally applied magnetic field. By varying the magnitude and gradient of the external magnetic field, the seed can be moved along a non-linear path and positioned at a site requiring therapy, e.g., a tumor. The magnetic field required for movement through brain tissue is extremely high, and is generated by a set of six superconducting magnets located in a housing surrounding the patient's head. The system uses two X-ray cameras positioned at right angles to detect in real time the locations of the seed and of X-ray opaque markers affixed to the patient's skull. the X-ray images are used to locate the objects of interest in a canonical frame of reference. the second case study is the University of Virginia Research Nuclear Reactor (UVAR). It is a 2 MW thermal, concrete-walled pool reactor. The system operates using 20 to 25 plate-type fuel assemblies placed on a rectangular grid plate. There are three scramable safety rods, and one non-scramable regulating rod that can be put in automatic mode. It was originally constructed in 1959 as a 1 MW system, and it was upgraded to 2 MW in 1973. Though only a research reactor rather than a power reactor, the issues raised are significant and can be related to the problems faced by full-scale reactor systems.

Knight, John C.

1995-01-01

5

Partial pressure analysis of plasmas  

SciTech Connect

The application of partial pressure analysis for plasma diagnostic measurements is reviewed. A comparison is made between the techniques of plasma flux analysis and partial pressure analysis for mass spectrometry of plasmas. Emphasis is given to the application of quadrupole mass spectrometers (QMS). The interface problems associated with the coupling of a QMS to a plasma device are discussed including: differential-pumping requirements, electromagnetic interferences from the plasma environment, the detection of surface-active species, ion source interactions, and calibration procedures. Example measurements are presented from process monitoring of glow discharge plasmas which are useful for cleaning and conditioning vacuum vessels.

Dylla, H.F.

1984-11-01

6

Nuclear Safety Analysis Center  

Microsoft Academic Search

Immediately after the Three Mile Island (TMI) accident, the US utility industry asked the Electric Power Research Institute (EPRI) to set up a Nuclear Safety Analysis Center (NSAC) charged with analyzing the accident, deriving lessons to be learned from it, and performing other safety-related functions. Financed by industry subscriptions and staffed with a nucleus of EPRI employees, with loaned employees

E. L. Zebroski; M. C. Leverett

1981-01-01

7

Physics analysis of the gang partial rod drive event  

SciTech Connect

During the routine positioning of partial-length control rods in Gang 3 on the afternoon of Monday, July 27, 1992, the partial-length rods continued to drive into the reactor even after the operator released the controlling toggle switch. In response to this occurrence, the Safety Analysis and Engineering Services Group (SAEG) requested that the Applied Physics Group (APG) analyze the gang partial rod drive event. Although similar accident scenarios were considered in analysis for Chapter 15 of the Safety Analysis Report (SAR), APG and SAEG conferred and agreed that this particular type of gang partial-length rod motion event was not included in the SAR. This report details this analysis.

Boman, C.; Frost, R.L.

1992-08-01

8

Nuclear Safety Analysis Center  

SciTech Connect

Immediately after the Three Mile Island (TMI) accident, the US utility industry asked the Electric Power Research Institute (EPRI) to set up a Nuclear Safety Analysis Center (NSAC) charged with analyzing the accident, deriving lessons to be learned from it, and performing other safety-related functions. Financed by industry subscriptions and staffed with a nucleus of EPRI employees, with loaned employees from utility companies, reactor manufacturers, national laboratories, and other industries, NSAC now has 35 to 40 professionals. The NSAC's present program is a natural outgrowth of its TMI investigation and involves: evaluation of significant plant operating events; nuclear power plant experience case studies; response to regulatory issues; generic safety studies; technical and operating information clearinghouse; and strategic analysis. The NSAC is fulfilling a need that probably existed in the industry for many years before the TMI accident and is expected to exist indefinitely.

Zebroski, E.L. (Electric Power Research Inst., Palo Alto, CA); Leverett, M.C.

1981-01-01

9

CONVEYOR SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose and objective of this analysis is to systematically identify and evaluate hazards related to the Yucca Mountain Project Exploratory Studies Facility (ESF) surface and subsurface conveyor system (for a list of conveyor subsystems see section 3). This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the conveyor structures/systems/components in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the structure/system/component (S/S/C) design, (2) add safety devices and capabilities to the designs that reduce risk, (3) provide devices that detect and warn personnel of hazardous conditions, and (4) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions. The scope of this analysis is limited to the hazards related to the design of conveyor structures/systems/components (S/S/Cs) that occur during normal operation. Hazards occurring during assembly, test and maintenance or ''off normal'' operations have not been included in this analysis. Construction related work activities are specifically excluded per DOE Order 5481.1B section 4. c.

M. Salem

1995-06-23

10

Flinders University Job Safety Analysis  

E-print Network

Flinders University Job Safety Analysis Date: Work Order/ Job No: Location: Description: Prepared:____________ Signature: Reviewed30-09-09 #12;Flinders University Job Safety Analysis F. U. Responsible Person

11

Using partial safety factors in wind turbine design and testing  

SciTech Connect

This paper describes the relationship between wind turbine design and testing in terms of the certification process. An overview of the current status of international certification is given along with a description of limit-state design basics. Wind turbine rotor blades are used to illustrate the principles discussed. These concepts are related to both International Electrotechnical Commission and Germanischer Lloyd design standards, and are covered using schematic representations of statistical load and material strength distributions. Wherever possible, interpretations of the partial safety factors are given with descriptions of their intended meaning. Under some circumstances, the authors` interpretations may be subjective. Next, the test-load factors are described in concept and then related to the design factors. Using technical arguments, it is shown that some of the design factors for both load and materials must be used in the test loading, but some should not be used. In addition, some test factors not used in the design may be necessary for an accurate test of the design. The results show that if the design assumptions do not clearly state the effects and uncertainties that are covered by the design`s partial safety factors, outside parties such as test labs or certification agencies could impose their own meaning on these factors.

Musial, W.D.; Butterfield, C.

1997-09-01

12

Model-Based Safety Analysis  

NASA Technical Reports Server (NTRS)

System safety analysis techniques are well established and are used extensively during the design of safety-critical systems. Despite this, most of the techniques are highly subjective and dependent on the skill of the practitioner. Since these analyses are usually based on an informal system model, it is unlikely that they will be complete, consistent, and error free. In fact, the lack of precise models of the system architecture and its failure modes often forces the safety analysts to devote much of their effort to gathering architectural details about the system behavior from several sources and embedding this information in the safety artifacts such as the fault trees. This report describes Model-Based Safety Analysis, an approach in which the system and safety engineers share a common system model created using a model-based development process. By extending the system model with a fault model as well as relevant portions of the physical system to be controlled, automated support can be provided for much of the safety analysis. We believe that by using a common model for both system and safety engineering and automating parts of the safety analysis, we can both reduce the cost and improve the quality of the safety analysis. Here we present our vision of model-based safety analysis and discuss the advantages and challenges in making this approach practical.

Joshi, Anjali; Heimdahl, Mats P. E.; Miller, Steven P.; Whalen, Mike W.

2006-01-01

13

Integrated Safety Analysis Teams  

NASA Technical Reports Server (NTRS)

Today's complex systems require understanding beyond one person s capability to comprehend. Each system requires a team to divide the system into understandable subsystems which can then be analyzed with an Integrated Hazard Analysis. The team must have both specific experiences and diversity of experience. Safety experience and system understanding are not always manifested in one individual. Group dynamics make the difference between success and failure as well as the difference between a difficult task and a rewarding experience. There are examples in the news which demonstrate the need to connect the pieces of a system into a complete picture. The Columbia disaster is now a standard example of a low consequence hazard in one part of the system; the External Tank is a catastrophic hazard cause for a companion subsystem, the Space Shuttle Orbiter. The interaction between the hardware, the manufacturing process, the handling, and the operations contributed to the problem. Each of these had analysis performed, but who constituted the team which integrated this analysis together? This paper will explore some of the methods used for dividing up a complex system; and how one integration team has analyzed the parts. How this analysis has been documented in one particular launch space vehicle case will also be discussed.

Wetherholt, Jonathan C.

2008-01-01

14

Aviation safety analysis  

E-print Network

Introduction: Just as the aviation system is complex and interrelated, so is aviation safety. Aviation safety involves design of aircraft and airports, training of ground personnel and flight crew members' maintenance of ...

Ausrotas, Raymond A.

1984-01-01

15

System safety engineering analysis handbook  

NASA Technical Reports Server (NTRS)

The basic requirements and guidelines for the preparation of System Safety Engineering Analysis are presented. The philosophy of System Safety and the various analytic methods available to the engineering profession are discussed. A text-book description of each of the methods is included.

Ijams, T. E.

1972-01-01

16

49 CFR 229.307 - Safety analysis.  

Code of Federal Regulations, 2013 CFR

...Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive Electronics § 229.307 Safety analysis. (a) A railroad shall develop a Safety Analysis (SA) for each product subject...

2013-10-01

17

49 CFR 229.307 - Safety analysis.  

Code of Federal Regulations, 2014 CFR

...Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive Electronics § 229.307 Safety analysis. (a) A railroad shall develop a Safety Analysis (SA) for each product subject...

2014-10-01

18

49 CFR 229.307 - Safety analysis.  

Code of Federal Regulations, 2012 CFR

...Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive Electronics § 229.307 Safety analysis. (a) A railroad shall develop a Safety Analysis (SA) for each product subject...

2012-10-01

19

Partial wave analysis using graphics processing units  

NASA Astrophysics Data System (ADS)

Partial wave analysis is an important tool for determining resonance properties in hadron spectroscopy. For large data samples however, the un-binned likelihood fits employed are computationally very expensive. At the Beijing Spectrometer (BES) III experiment, an increase in statistics compared to earlier experiments of up to two orders of magnitude is expected. In order to allow for a timely analysis of these datasets, additional computing power with short turnover times has to be made available. It turns out that graphics processing units (GPUs) originally developed for 3D computer games have an architecture of massively parallel single instruction multiple data floating point units that is almost ideally suited for the algorithms employed in partial wave analysis. We have implemented a framework for tensor manipulation and partial wave fits called GPUPWA. The user writes a program in pure C++ whilst the GPUPWA classes handle computations on the GPU, memory transfers, caching and other technical details. In conjunction with a recent graphics processor, the framework provides a speed-up of the partial wave fit by more than two orders of magnitude compared to legacy FORTRAN code.

Berger, Niklaus; Beijiang, Liu; Jike, Wang

2010-04-01

20

Adapting safety requirements analysis to intrusion detection  

NASA Technical Reports Server (NTRS)

Several requirements analysis techniques widely used in safety-critical systems are being adapted to support the analysis of secure systems. Perhaps the most relevant system safety techique for Intrusion Detection Systems is hazard analysis.

Lutz, R.

2001-01-01

21

Job Safety Analysis (JSA) College of Engineering  

E-print Network

Job Safety Analysis (JSA) College of Engineering Personnel Department: Mechanical Engineering Analysis Summary Information College: College of Engineering Department: Mechanical Engineering Job. Federal Legislation ­ Bill C-45 The following Job Safety Analysis outlines job-specific activities, known

Saskatchewan, University of

22

SEISMIC ANALYSIS FOR PRECLOSURE SAFETY  

SciTech Connect

The purpose of this seismic preclosure safety analysis is to identify the potential seismically-initiated event sequences associated with preclosure operations of the repository at Yucca Mountain and assign appropriate design bases to provide assurance of achieving the performance objectives specified in the Code of Federal Regulations (CFR) 10 CFR Part 63 for radiological consequences. This seismic preclosure safety analysis is performed in support of the License Application for the Yucca Mountain Project. In more detail, this analysis identifies the systems, structures, and components (SSCs) that are subject to seismic design bases. This analysis assigns one of two design basis ground motion (DBGM) levels, DBGM-1 or DBGM-2, to SSCs important to safety (ITS) that are credited in the prevention or mitigation of seismically-initiated event sequences. An application of seismic margins approach is also demonstrated for SSCs assigned to DBGM-2 by showing a high confidence of a low probability of failure at a higher ground acceleration value, termed a beyond-design basis ground motion (BDBGM) level. The objective of this analysis is to meet the performance requirements of 10 CFR 63.111(a) and 10 CFR 63.111(b) for offsite and worker doses. The results of this calculation are used as inputs to the following: (1) A classification analysis of SSCs ITS by identifying potential seismically-initiated failures (loss of safety function) that could lead to undesired consequences; (2) An assignment of either DBGM-1 or DBGM-2 to each SSC ITS credited in the prevention or mitigation of a seismically-initiated event sequence; and (3) A nuclear safety design basis report that will state the seismic design requirements that are credited in this analysis. The present analysis reflects the design information available as of October 2004 and is considered preliminary. The evolving design of the repository will be re-evaluated periodically to ensure that seismic hazards are properly evaluated and identified. This document supersedes the seismic classifications, assignments, and computations in ''Seismic Analysis for Preclosure Safety'' (BSC 2004a).

E.N. Lindner

2004-12-03

23

[Cultural safety: a concept analysis].  

PubMed

Cultural safety is a concept that is getting more attention in scientific literature related to the cultural dimension of care. Difficulty to grasp the meaning and implications for research, education and practice is frequently raised by the authors. A concept analysis inspired by the evolutionary method of Rodgers was performed to better understand its meaning and its utility to the various fields of nursing. A systematic review of the literature was conducted in the databases CINAHL, PsycINFO, MEDLINE, EMBASE, ERIC, and Sociological Abstracts to identify literature published between 1988 and 2012 and containing the expression "cultural safety". 68 documents were analyzed. Findings included attributes, antecedents and consequences of cultural safety. The evolution of cultural safety through the various sociocultural and political contexts and application domains is also addressed. Issues related to the definition and operationalization of the concept, as well as the ability to export it out of its context of emergence, are discussed. The concept of cultural safety needs further development and a theoretical integration before reaching a conceptual clarity and effective operationalization. PMID:23409542

Blanchet Garneau, Amélie; Pepin, Jacinthe

2012-12-01

24

Job Safety Analysis College/Department/Unit  

E-print Network

Job Safety Analysis (JSA) College/Department/Unit: Title of Job Activity: Hydraulic Press Location the Job Safety Analysis: Date Signature #12;JSA # Page 3 Basic Job Steps Possible Hazards Preventative

Saskatchewan, University of

25

Job Safety Analysis College/Department/Unit  

E-print Network

Job Safety Analysis (JSA) College/Department/Unit: Title of Job Activity: Oven Location of Activity and understanding the Job Safety Analysis: Date Name (Print) Signature #12;JSA # Page 3 Basic Job Steps Possible

Saskatchewan, University of

26

Safety study application guide. Safety Analysis Report Update Program  

SciTech Connect

Martin Marietta Energy Systems, Inc., (Energy Systems) is committed to performing and documenting safety analyses for facilities it manages for the Department of Energy (DOE). Included are analyses of existing facilities done under the aegis of the Safety Analysis Report Upgrade Program, and analyses of new and modified facilities. A graded approach is used wherein the level of analysis and documentation for each facility is commensurate with the magnitude of the hazard(s), the complexity of the facility and the stage of the facility life cycle. Safety analysis reports (SARs) for hazard Category 1 and 2 facilities are usually detailed and extensive because these categories are associated with public health and safety risk. SARs for Category 3 are normally much less extensive because the risk to public health and safety is slight. At Energy Systems, safety studies are the name given to SARs for Category 3 (formerly {open_quotes}low{close_quotes}) facilities. Safety studies are the appropriate instrument when on-site risks are limited to irreversible consequences to a few people, and off-site consequences are limited to reversible consequences to a few people. This application guide provides detailed instructions for performing safety studies that meet the requirements of DOE Orders 5480.22, {open_quotes}Technical Safety Requirements,{close_quotes} and 5480.23, {open_quotes}Nuclear Safety Analysis Reports.{close_quotes} A seven-chapter format has been adopted for safety studies. This format allows for discussion of all the items required by DOE Order 5480.23 and for the discussions to be readily traceable to the listing in the order. The chapter titles are: (1) Introduction and Summary, (2) Site, (3) Facility Description, (4) Safety Basis, (5) Hazardous Material Management, (6) Management, Organization, and Institutional Safety Provisions, and (7) Accident Analysis.

Not Available

1993-07-01

27

Systems engineered health and safety criteria for safety analysis reports  

SciTech Connect

The world of safety analysis is filled with ambiguous words: codes and standards; consequences and risks; hazard and accident, and health and safety. These words have been subject to disparate interpretations by Safety Analysis Report (SAR) writers, readers and users. ``Principal health and safety criteria`` has been one of the most frequently misused terms; rarely is it used consistently or effectively. This paper offers an easily understood definition for ``principal health and safety criteria,`` and uses systems engineering to convert an otherwise mysterious topic into the primary means of producing an integrated SAR. This paper is based upon SARs being written for Environmental Restoration & Waste Management activities for the Department of Energy (DOE). Requirements for these SARs are prescribed in DOE Order 5480.23, ``Nuclear Safety Analysis Reports``.

Beitel, G.A.; Morcos, N.

1993-08-01

28

Parental concern about vaccine safety in Canadian children partially immunized at age 2: a multivariable model including system level factors.  

PubMed

Children who begin but do not fully complete the recommended series of childhood vaccines by 2 y of age are a much larger group than those who receive no vaccines. While parents who refuse all vaccines typically express concern about vaccine safety, it is critical to determine what influences parents of 'partially' immunized children. This case-control study examined whether parental concern about vaccine safety was responsible for partial immunization, and whether other personal or system-level factors played an important role. A random sample of parents of partially and completely immunized 2 y old children were selected from a Canadian regional immunization registry and completed a postal survey assessing various personal and system-level factors. Unadjusted odds ratios (OR) and adjusted ORs (aOR) were calculated with logistic regression. While vaccine safety concern was associated with partial immunization (OR 7.338, 95% CI 4.138-13.012), other variables were more strongly associated and reduced the strength of the relationship between concern and partial immunization in multivariable analysis (aOR 2.829, 95% CI 1.151-6.957). Other important factors included perceived disease susceptibility and severity (aOR 4.629, 95% CI 2.017-10.625), residential mobility (aOR 3.908, 95% CI 2.075-7.358), daycare use (aOR 0.310, 95% CI 0.144-0.671), number of needles administered at each visit (aOR 7.734, 95% CI 2.598-23.025) and access to a regular physician (aOR 0.219, 95% CI 0.057-0.846). While concern about vaccine safety may be addressed through educational strategies, this study suggests that additional program and policy-level strategies may positively impact immunization uptake. PMID:25483477

MacDonald, Shannon E; Schopflocher, Donald P; Vaudry, Wendy

2014-01-01

29

Solid waste burial grounds interim safety analysis  

SciTech Connect

This Interim Safety Analysis document supports the authorization basis for the interim operation and restrictions on interim operations for the near-surface land disposal of solid waste in the Solid Waste Burial Grounds. The Solid Waste Burial Grounds Interim Safety Basis supports the upgrade progress for the safety analysis report and the technical safety requirements for the operations in the Solid Waste Burial Grounds. Accident safety analysis scenarios have been analyzed based on the significant events identified in the preliminary hazards analysis. The interim safety analysis provides an evaluation of the operations in the Solid Waste Burial Grounds to determine if the radiological and hazardous material exposures will be acceptable from an overall health and safety standpoint to the worker, the onsite personnel, the public, and the environment.

Saito, G.H.

1994-10-01

30

The new BNL partial wave analysis programs  

SciTech Connect

Experiment E852 at Brookhaven National Laboratory is a meson spectroscopy experiment which took data at the Multi-Particle Spectrometer facility of the Alternating Gradient Syncrotron. Upgrades to the spectrometer`s data acquisition and trigger electronics allowed over 900 million data events, of numerous topologies, to be recorded to tape in 1995 running alone. One of the primary goals of E852 is identification of states beyond the quark model, i.e., states with gluonic degrees of freedom. Identification of such states involves the measurement of a systems spin-parity. Such a measurement is usually done using Partial Wave Analysis. Programs to perform such analyses exist, in fact, one was written at BNL and used in previous experiments by some of this group. This program, however, was optimized for a particular final state, and modification to allow analysis of the broad range of final states in E852 would have been difficult. The authors therefore decided to write a new program, with an eye towards generality that would allow analysis of a large class of reactions.

Cummings, J.P.; Weygand, D.P.

1997-07-29

31

Assuring the quality of safety analyses and safety analysis documentation  

SciTech Connect

Planning, preparation, and submittal of safety analysis reports might be pursued in a manner similar to a quality-related procurement, where customer needs, expectations and acceptance criteria are established in advance. Then the product/service provider, the contractor, should apply various quality control processes to assure the desired characteristics of the product safety analysis documents. Improving the quality and acceptability to DOE of safety documents at first submittal should result in a more expeditious DOE review and approval process, thereby reducing costs of network and recycle through reviews.

J. E. Johnson

2000-05-03

32

Assuring the Quality of Safety Analyses and Safety Analysis Documentation  

SciTech Connect

Planning, preparation, and submittal of safety analysis reports might be pursued in a manner similar to a quality-related procurement, where customer needs, expectations and acceptance criteria are established in advance. Then the product/service provider, the contractor, should apply various quality control processes to assure the desired characteristics of the product safety analysis documents. Improving the quality and acceptability to DOE of safety documents at first submittal should result in a more expeditious DOE review and approval process, thereby reducing costs of network and recycle through reviews.

Johnson, John Edwin

2000-05-01

33

14 CFR 33.75 - Safety analysis.  

Code of Federal Regulations, 2012 CFR

...FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.75 Safety analysis. (a) (1) The applicant must analyze...

2012-01-01

34

14 CFR 33.75 - Safety analysis.  

Code of Federal Regulations, 2014 CFR

...FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.75 Safety analysis. (a) (1) The applicant must analyze...

2014-01-01

35

14 CFR 33.75 - Safety analysis.  

Code of Federal Regulations, 2011 CFR

...FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.75 Safety analysis. (a) (1) The applicant must analyze...

2011-01-01

36

14 CFR 33.75 - Safety analysis.  

Code of Federal Regulations, 2013 CFR

...FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.75 Safety analysis. (a) (1) The applicant must analyze...

2013-01-01

37

Automation for System Safety Analysis  

NASA Technical Reports Server (NTRS)

This presentation describes work to integrate a set of tools to support early model-based analysis of failures and hazards due to system-software interactions. The tools perform and assist analysts in the following tasks: 1) extract model parts from text for architecture and safety/hazard models; 2) combine the parts with library information to develop the models for visualization and analysis; 3) perform graph analysis and simulation to identify and evaluate possible paths from hazard sources to vulnerable entities and functions, in nominal and anomalous system-software configurations and scenarios; and 4) identify resulting candidate scenarios for software integration testing. There has been significant technical progress in model extraction from Orion program text sources, architecture model derivation (components and connections) and documentation of extraction sources. Models have been derived from Internal Interface Requirements Documents (IIRDs) and FMEA documents. Linguistic text processing is used to extract model parts and relationships, and the Aerospace Ontology also aids automated model development from the extracted information. Visualizations of these models assist analysts in requirements overview and in checking consistency and completeness.

Malin, Jane T.; Fleming, Land; Throop, David; Thronesbery, Carroll; Flores, Joshua; Bennett, Ted; Wennberg, Paul

2009-01-01

38

Safety analysis of an evolving software architecture  

Microsoft Academic Search

The safety analysis of an evolving software system has to consider the impact that changes might have on the software components, and to provide confidence that the risk is acceptable. If the impact of a change is not thoroughly analysed, accidents can occur as a result of faulty interactions between components, for example. However, the process of safety analysis can

Rogerio de Lemos

2000-01-01

39

Job Safety Analysis College/Department/Unit  

E-print Network

Job Safety Analysis (JSA) College/Department/Unit: Title of Job Activity: Knife Use Location and understanding the Job Safety Analysis: Date Name (Print) Signature #12;JSA # Page 3 Basic Job Steps Possible course and provided in this document - Always use the right type of knife for the type of job, as defined

Saskatchewan, University of

40

Job Safety Analysis College/Department/Unit  

E-print Network

Job Safety Analysis (JSA) College/Department/Unit: Title of Job Activity: Lifting devices, ladders Reviewed By Signature Individual worker sign off for reading and understanding the Job Safety Analysis: Date Signature #12;JSA # Page 3 Basic Job Steps Possible Hazards Preventative Measures Using lifts, JLG

Saskatchewan, University of

41

Hot Cell Facility (HCF) Safety Analysis Report  

SciTech Connect

This Safety Analysis Report (SAR) is prepared in compliance with the requirements of DOE Order 5480.23, Nuclear Safety Analysis Reports, and has been written to the format and content guide of DOE-STD-3009-94 Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Safety Analysis Reports. The Hot Cell Facility is a Hazard Category 2 nonreactor nuclear facility, and is operated by Sandia National Laboratories for the Department of Energy. This SAR provides a description of the HCF and its operations, an assessment of the hazards and potential accidents which may occur in the facility. The potential consequences and likelihood of these accidents are analyzed and described. Using the process and criteria described in DOE-STD-3009-94, safety-related structures, systems and components are identified, and the important safety functions of each SSC are described. Additionally, information which describes the safety management programs at SNL are described in ancillary chapters of the SAR.

MITCHELL,GERRY W.; LONGLEY,SUSAN W.; PHILBIN,JEFFREY S.; MAHN,JEFFREY A.; BERRY,DONALD T.; SCHWERS,NORMAN F.; VANDERBEEK,THOMAS E.; NAEGELI,ROBERT E.

2000-11-01

42

10 CFR 70.62 - Safety program and integrated safety analysis.  

Code of Federal Regulations, 2010 CFR

...maintain an integrated safety analysis...complexity of the process, that identifies... (ii) Chemical hazards of...specific to each process being evaluated...safety, and chemical process safety. One...the specific integrated safety...

2010-01-01

43

Infusing Reliability Techniques into Software Safety Analysis  

NASA Technical Reports Server (NTRS)

Software safety analysis for a large software intensive system is always a challenge. Software safety practitioners need to ensure that software related hazards are completely identified, controlled, and tracked. This paper discusses in detail how to incorporate the traditional reliability techniques into the entire software safety analysis process. In addition, this paper addresses how information can be effectively shared between the various practitioners involved in the software safety analyses. The author has successfully applied the approach to several aerospace applications. Examples are provided to illustrate the key steps of the proposed approach.

Shi, Ying

2015-01-01

44

10 CFR 830.204 - Documented safety analysis.  

Code of Federal Regulations, 2010 CFR

...documented safety analysis for the facility...documented safety analysis for a hazard category...facility (including the design of safety structures, systems and components) and...consideration of the need for analysis of accidents...

2010-01-01

45

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2012 CFR

...213 Flight safety limits analysis. (a) General. A flight safety analysis must identify the location...launch satisfies the public risk criteria of § 417.107...Flight safety limits. The analysis must establish...

2012-01-01

46

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2013 CFR

...213 Flight safety limits analysis. (a) General. A flight safety analysis must identify the location...launch satisfies the public risk criteria of § 417.107...Flight safety limits. The analysis must establish...

2013-01-01

47

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2014 CFR

...213 Flight safety limits analysis. (a) General. A flight safety analysis must identify the location...launch satisfies the public risk criteria of § 417.107...Flight safety limits. The analysis must establish...

2014-01-01

48

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2010 CFR

...213 Flight safety limits analysis. (a) General. A flight safety analysis must identify the location...launch satisfies the public risk criteria of § 417.107...Flight safety limits. The analysis must establish...

2010-01-01

49

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2011 CFR

...213 Flight safety limits analysis. (a) General. A flight safety analysis must identify the location...launch satisfies the public risk criteria of § 417.107...Flight safety limits. The analysis must establish...

2011-01-01

50

Probabilistic safety analysis. Interim report No. 1  

Microsoft Academic Search

This report summarizes work carried out during the first year of LWR probabilistic safety analysis. A large amount of useful source material was provided by the draft report of the Reactor Safety Study (WASH-1400), and much of the SAI activity during the past year was based upon the Study's methods, data, and results. Chapters 2 and 3 of this document

R. C. Erdmann; R. R. Fullwood; A. A. Garcia; J. E. Kelly; F. L. Leverenz

1975-01-01

51

Reliability analysis of MURR safety functions  

Microsoft Academic Search

This study investigated use of improved methods of reliability analysis (over those used in the WASH-1400 report) in reactor safety studies. The methods of event and fault trees that are used to analyze the accident sequences and the safety functions are described. Most importantly, an improvement over the current methods is used to construct the correct mathematical relationship between a

Malliakos

1980-01-01

52

HANFORD SAFETY ANALYSIS & RISK ASSESSMENT HANDBOOK (SARAH)  

SciTech Connect

The purpose of the Hanford Safety Analysis and Risk Assessment Handbook (SARAH) is to support the development of safety basis documentation for Hazard Category 2 and 3 (HC-2 and 3) U.S. Department of Energy (DOE) nuclear facilities to meet the requirements of 10 CFR 830, ''Nuclear Safety Management''. Subpart B, ''Safety Basis Requirements.'' Consistent with DOE-STD-3009-94, Change Notice 2, ''Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'' (STD-3009), and DOE-STD-3011-2002, ''Guidance for Preparation of Basis for Interim Operation (BIO) Documents'' (STD-3011), the Hanford SARAH describes methodology for performing a safety analysis leading to development of a Documented Safety Analysis (DSA) and derivation of Technical Safety Requirements (TSR), and provides the information necessary to ensure a consistently rigorous approach that meets DOE expectations. The DSA and TSR documents, together with the DOE-issued Safety Evaluation Report (SER), are the basic components of facility safety basis documentation. For HC-2 or 3 nuclear facilities in long-term surveillance and maintenance (S&M), for decommissioning activities, where source term has been eliminated to the point that only low-level, residual fixed contamination is present, or for environmental remediation activities outside of a facility structure, DOE-STD-1120-98, ''Integration of Environment, Safety, and Health into Facility Disposition Activities'' (STD-1120), may serve as the basis for the DSA. HC-2 and 3 environmental remediation sites also are subject to the hazard analysis methodologies of this standard.

EVANS, C B

2004-12-21

53

A Synthetic Vision Preliminary Integrated Safety Analysis  

NASA Technical Reports Server (NTRS)

This report documents efforts to analyze a sample of aviation safety programs, using the LMI-developed integrated safety analysis tool to determine the change in system risk resulting from Aviation Safety Program (AvSP) technology implementation. Specifically, we have worked to modify existing system safety tools to address the safety impact of synthetic vision (SV) technology. Safety metrics include reliability, availability, and resultant hazard. This analysis of SV technology is intended to be part of a larger effort to develop a model that is capable of "providing further support to the product design and development team as additional information becomes available". The reliability analysis portion of the effort is complete and is fully documented in this report. The simulation analysis is still underway; it will be documented in a subsequent report. The specific goal of this effort is to apply the integrated safety analysis to SV technology. This report also contains a brief discussion of data necessary to expand the human performance capability of the model, as well as a discussion of human behavior and its implications for system risk assessment in this modeling environment.

Hemm, Robert; Houser, Scott

2001-01-01

54

Satellite System Safety Analysis Using STPA  

E-print Network

Traditional hazard analysis techniques based on failure models of accident causality, such as the probabilistic risk assessment (PRA) method currently used at NASA, are inadequate for analyzing safety at the system level. ...

Dunn, Nicholas Connor

2013-01-01

55

Autoclave nuclear criticality safety analysis  

SciTech Connect

Steam-heated autoclaves are used in gaseous diffusion uranium enrichment plants to heat large cylinders of UF{sub 6}. Nuclear criticality safety for these autoclaves is evaluated. To enhance criticality safety, systems are incorporated into the design of autoclaves to limit the amount of water present. These safety systems also increase the likelihood that any UF{sub 6} inadvertently released from a cylinder into an autoclave is not released to the environment. Up to 140 pounds of water can be held up in large autoclaves. This mass of water is sufficient to support a nuclear criticality when optimally combined with 125 pounds of UF{sub 6} enriched to 5 percent U{sup 235}. However, water in autoclaves is widely dispersed as condensed droplets and vapor, and is extremely unlikely to form a critical configuration with released UF{sub 6}.

D`Aquila, D.M. [Martin Marietta Energy Systems, Inc., Piketon, OH (United States); Tayloe, R.W. Jr. [Battelle, Columbus, OH (United States)

1991-12-31

56

PRINCIPAL COMPONENTS ANALYSIS AND PARTIAL LEAST SQUARES REGRESSION  

EPA Science Inventory

The mathematics behind the techniques of principal component analysis and partial least squares regression is presented in detail, starting from the appropriate extreme conditions. he meaning of the resultant vectors and many of their mathematical interrelationships are also pres...

57

Safety analysis of a microgrid  

Microsoft Academic Search

Microgrids are attracting substantial interest because they have the potential to increase the use of renewable generation and micro-CHP. They can also defer investment in distribution capital plant and can improve local power quality. However the primary operational requirement of power systems is that they must operate safely from a user point of view, even during contingencies. Yet electrical safety

N. Jayawarna; N. Jenkins; M. Barnes; M. Lorentzou; S. Papthanassiou; N. Hatziagyriou

2005-01-01

58

Uncertainty analysis for Ulysses safety evaluation report  

NASA Technical Reports Server (NTRS)

As part of the effort to review the Ulysses Final Safety Analysis Report and to understand the risk of plutonium release from the Ulysses spacecraft General Purpose Heat Source-Radioisotope Thermal Generator, the Interagency Nuclear Safety Review Panel (INSRP) performed an integrated, quantitative analysis of the uncertainties of the calculated risk of plutonium release from Ulysses. Using state-of-art probabilistic risk assessment technology, the uncertainty analysis accounted for both variability and uncertainty of the key parameters of the risk analysis. The results show that INSRP had high confidence that risk of fatal cancers from potential plutonium release associated with calculated launch and deployment accident scenarios is low.

Frank, Michael V.

1991-01-01

59

Invariant painlevé analysis of partial differential equations  

Microsoft Academic Search

The whole Painlevé analysis of PDEs is shown to be invariant under an arbitrary homographic transformation of the function varphi defining the singularity manifold. The best expansion function is varkappa = (varphix\\/varphi-varphixx\\/2varphix)-1. This solves the ques tion of invariance under the Möbius group in Painlevé analysis and explains naturally Bäcklund transformation between solutions.

Robert Conte

1989-01-01

60

Partial Wave Analysis of Coupled Photonic Structures  

NASA Technical Reports Server (NTRS)

The very high quality factors sustained by microcavity optical resonators are relevant to applications in wavelength filtering, routing, switching, modulation, and multiplexing/demultiplexing. Increases in the density of photonic elements require that attention be paid to how electromagnetic (EM) coupling modifies their optical properties. This is especially true when cavity resonances are involved, in which case, their characteristics may be fundamentally altered. Understanding the optical properties of microcavities that are near or in contact with photonic elements---such as other microcavities, nanostructures, couplers, and substrates---can be expected to advance our understanding of the roles that these structures may play in VLSI photonics, biosensors and similar device technologies. Wc present results from recent theoretical studies of the effects of inter- and intracavity coupling on optical resonances in compound spherical particles. Concentrically stratified spheres and bispheres constituted from homogeneous and stratified spheres are subjects of this investigation. A new formulation is introduced for the absorption of light in an arbitrary layer of a multilayered sphere, which is based on multiple reflections of the spherical partial waves of the Lorenz-Mie solution for scattering by a sphere. Absorption efficiencies, which can be used to profile cavity resonances and to infer fluorescence yields or the onset of nonlinear optical processes in the microcavities, are presented. Splitting of resonances in these multisphere systems is paid particular attention, and consequences for photonic device development and possible performance enhancements through carefully designed architectures that exploit EM coupling are considered.

Fuller, Kirk A.; Smith, David D.; Curreri, Peter A. (Technical Monitor)

2002-01-01

61

SAFEGUARDS AND SECURITY INTEGRATION WITH SAFETY ANALYSIS  

SciTech Connect

The objective of this paper is to share the Savannah River Site lessons learned on Safeguards and Security (S&S) program integration with K-Area Complex (KAC) safety basis. The KAC Documented Safety Analysis (DSA), is managed by the Washington Savannah River Company (WSRC), and the S&S program, managed by Wackenhut Services, Incorporated--Savannah River Site (WSI-SRS). WSRC and WSI-SRS developed a contractual arrangement to recognize WSI-SRS requirements in the KAC safety analysis. Design Basis Threat 2003 (DBT03) security upgrades required physical modifications and operational changes which included the availability of weapons which could potentially impact the facility safety analysis. The KAC DSA did not previously require explicit linkage to the S&S program to satisfy the safety analysis. WSI-SRS have contractual requirements with the Department of Energy (DOE) which are separate from WSRC contract requirements. The lessons learned will include a discussion on planning, analysis, approval of the controls and implementation issues.

Hearn, J; James Lightner, J

2007-04-13

62

K West integrated water treatment system subproject safety analysis document  

SciTech Connect

This Accident Analysis evaluates unmitigated accident scenarios, and identifies Safety Significant and Safety Class structures, systems, and components for the K West Integrated Water Treatment System.

SEMMENS, L.S.

1999-02-24

63

Quantitative NMR Analysis of Partially Substituted Biodiesel Glycerols  

SciTech Connect

Phosphitylation of hydroxyl groups in biodiesel samples with 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane followed by 31P-NMR analysis provides a rapid quantitative analytical technique for the determination of substitution patterns on partially esterified glycerols. The unique 31P-NMR chemical shift data was established with a series mono and di-substituted fatty acid esters of glycerol and then utilized to characterize an industrial sample of partially processed biodiesel.

Nagy, M.; Alleman, T. L.; Dyer, T.; Ragauskas, A. J.

2009-01-01

64

SAS Partial Least Squares (PLS) for Discriminant Analysis  

Technology Transfer Automated Retrieval System (TEKTRAN)

The objective of this work was to implement discriminant analysis using SAS partial least squares (PLS) regression for analysis of spectral data. This was done in combination with previous efforts which implemented data pre-treatments including scatter correction, derivatives, mean centering, and v...

65

Analysis of partial AZFc deletions in Malaysian infertile male subjects.  

PubMed

Complete deletions in the AZF (a, b, and c) sub-regions of the Y-chromosome have been shown to contribute to unexplained male infertility. However, the role of partial AZFc deletions in male infertility remains to be verified. Three types of partial AZFc deletions have been identified. They are gr/gr, b1/b3, and b2/b3 deletions. A recent meta-analysis showed that ethnic and geographical factors might contribute to the association of partial AZFc deletions with male infertility. This study analyzed the association of partial AZFc deletions in Malaysian infertile males. Fifty two oligozoospermic infertile males and 63 fertile controls were recruited to this study. Screening for partial AZFc deletions was done using the two sequence-tagged sites approach (SY1291 and SY1191) which were analyzed using both the conventional PCR gel-electrophoresis and the high resolution melt, HRM method. Gr/gr deletions were found in 11.53% of the cases and 9.52% of the controls (p?=?0.725). A B2/b3 deletion was found in one of the cases (p?=?0.269). No B1/b3 deletions were identified in this study. The results of HRM analysis were consistent with those obtained using the conventional PCR gel-electrophoresis method. The HRM analysis was highly repeatable (95% limit of agreement was -0.0879 to 0.0871 for SY1191 melting temperature readings). In conclusion, our study showed that partial AZFc deletions were not associated with male infertility in Malaysian subjects. HRM analysis was a reliable, repeatable, fast, cost-effective, and semi-automated method which can be used for screening of partial AZFc deletions. PMID:23231020

Almeamar, Hussein Ali; Ramachandran, Vasudevan; Ismail, Patimah; Nadkarni, Prashan; Fawzi, Nora

2013-04-01

66

SYNTHESIS OF SAFETY ANALYSIS AND FIRE HAZARD ANALYSIS METHODOLOGIES  

SciTech Connect

Successful implementation of both the nuclear safety program and fire protection program is best accomplished using a coordinated process that relies on sound technical approaches. When systematically prepared, the documented safety analysis (DSA) and fire hazard analysis (FHA) can present a consistent technical basis that streamlines implementation. If not coordinated, the DSA and FHA can present inconsistent conclusions, which can create unnecessary confusion and can promulgate a negative safety perception. This paper will compare the scope, purpose, and analysis techniques for DSAs and FHAs. It will also consolidate several lessons-learned papers on this topic, which were prepared in the 1990s.

Coutts, D

2007-04-17

67

Partial analysis of experiment LDEF A-0114  

NASA Technical Reports Server (NTRS)

Due to delays in manifesting the return of the Long Duration Exposure Facility from space, attention was concentrated on extracting the maximum information from the EIOM-2 (oxygen interaction with materials experiment) flown on STS-8 in September 1983. An analysis was made of the optical surfaces exposed during that flight and an assessment made of the effect of the 5 eV atomic oxygen upon their physical and chemical properties. The surfaces studied were of two types: high-purity thin films sputtered or evaporated onto 2.54-cm diam lambda/20 fused silica optical flats, and highly polished bulk samples. Rapid etching of carbon and carbonaceous surfaces was observed with polycarbonate CR-39 showing the largest etch of any substrate flown and measured. Of the metals tested, only osmium and silver showed large effects, the former being heavily etched and the later forming a very thick layer of oxide. The first measurable effects on iridium, aluminum, nickel, tungsten and niobium thin films are reported.

Gregory, J. C.

1986-01-01

68

DESIGN PACKAGE 1E SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate hazards related to the Yucca Mountain Project Exploratory Studies Facility (ESF) Design Package 1E, Surface Facilities, (for a list of design items included in the package 1E system safety analysis see section 3). This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the Design Package 1E structures/systems/components(S/S/Cs) in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the structure/system/component design, (2) add safety devices and capabilities to the designs that reduce risk, (3) provide devices that detect and warn personnel of hazardous conditions, and (4) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions.

M. Salem

1995-06-23

69

Development of a safety analysis system for the offshore personnel and equipment transfer process  

E-print Network

DEVELOPMENT OF A SAFETY ANALYSIS SYSTEM FOR THE OFFSHORE PERSONNEL AND EQUIPMENT TRANSFER PROCESS A Thesis by MICHAEL GEORGE McKENNA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE V Z December 1988 0 Z s Z LJ z X I Major Subject: Safety Engineering DEVELOPMENT OF A SAFETY ANALYSIS SYSTEM FOR THE OFFSHORE PERSONNEL AND EQUIPMENT TRANSFER PROCESS A Thesis by MICHAEL GEORGE Mc...

McKenna, Michael George

1988-01-01

70

SLAC three-body partial wave analysis system  

SciTech Connect

We present a heuristic description of the SLAC-LBL three-meson partial wave model, and describe how we have implemented it at SLAC. The discussion details the assumptions of the model and the analysis, and emphasizes the methods we have used to prepare and fit the data. 28 refs., 12 figs., 1 tab.

Aston, D.; Lasinski, T.A.; Sinervo, P.K.

1985-10-01

71

A Partial Equilibrium Analysis of Trade with Decreasing Transport Costs  

Microsoft Academic Search

Decreasing transport costs are incorporated in the standard partial equilibrium analysis of trade by allowing the divergence—introduced by transport costs—between export and import price to decrease with the volume of trade. When the excess demand (supply) curve is steeper than the long run average cost curve for imports (exports), we observe that an import (export) tariff raises (lowers) the domestic

M. S Alam

1991-01-01

72

TRIAGE DOSE ASSESSMENT FOR PARTIAL-BODY EXPOSURE: DICENTRIC ANALYSIS  

PubMed Central

Partial-body biodosimetry is likely to be required after a radiological or nuclear exposure. Clinical signs and symptoms, distribution of dicentrics in circulating blood cells, organ-specific biomarkers, physical signals in teeth and nails all can provide indications of non-homogeneous exposures. Organ specific biomarkers may provide early warning regarding physiological systems at risk after radiation injury. Use of a combination of markers and symptoms will be needed for clinical insights for therapeutic approaches. Analysis of dicentrics, a marker specific for radiation injury, is the “Gold standard” of biodosimetry and can reveal partial-body exposures. Automation of sample processing for dicentric analysis can increase throughput with customization of off-the-shelf technologies for cytogenetic sample processing and information management. Automated analysis of the metaphase spreads is currently limited but improvements are in development. Our efforts bridge the technological gaps to allow the use of dicentric chromosome assay (DCA) for risk-based stratification of mass casualties. This article summarizes current knowledge on partial-body cytogenetic dose assessment synthesizing information leading to the proposal of an approach to triage dose prediction in radiation mass casualties, based on equivalent whole-body doses under partial-body exposure conditions and assesses the validity of using this model. An initial screening using only 20 metaphase spreads per subject can confirm irradiation above 2-Gy. A subsequent increase to 50 metaphases improves dose determination to allow risk stratification for clinical triage. Metaphases evaluated for inhomogeneous distribution of dicentrics can reveal partial-body exposures. We tested the validity of this approach in an in vitro model that simulates partial-body irradiation by mixing irradiated and un-irradiated lymphocytes in various proportions. Our preliminary results support the notion that this approach will be effective under a range of conditions including some partial-body exposures, but may have limitations with low doses or small proportions of irradiated body. Our studies address an important problem in the diagnosis of partial-body irradiation and dose assessment in mass casualties and propose a solution. However, additional work is needed to fully develop and validate the application of DCA to partial-body exposures. PMID:20065689

Moroni, Maria; Pellmar, Terry C.

2009-01-01

73

COLD-SAT feasibility study safety analysis  

NASA Technical Reports Server (NTRS)

The Cryogenic On-orbit Liquid Depot-Storage, Acquisition, and Transfer (COLD-SAT) satellite presents some unique safety issues. The feasibility study conducted at NASA-Lewis desired a systems safety program that would be involved from the initial design in order to eliminate and/or control the inherent hazards. Because of this, a hazards analysis method was needed that: (1) identified issues that needed to be addressed for a feasibility assessment; and (2) identified all potential hazards that would need to be controlled and/or eliminated during the detailed design phases. The developed analysis method is presented as well as the results generated for the COLD-SAT system.

Mchenry, Steven T.; Yost, James M.

1991-01-01

74

Safety of GM crops: compositional analysis.  

PubMed

The compositional analysis of genetically modified (GM) crops has continued to be an important part of the overall evaluation in the safety assessment program for these materials. The variety and complexity of genetically engineered traits and modes of action that will be used in GM crops in the near future, as well as our expanded knowledge of compositional variability and factors that can affect composition, raise questions about compositional analysis and how it should be applied to evaluate the safety of traits. The International Life Sciences Institute (ILSI), a nonprofit foundation whose mission is to provide science that improves public health and well-being by fostering collaboration among experts from academia, government, and industry, convened a workshop in September 2012 to examine these and related questions, and a series of papers has been assembled to describe the outcomes of that meeting. PMID:24266762

Brune, Philip D; Culler, Angela Hendrickson; Ridley, William P; Walker, Kate

2013-09-01

75

Computer graphics in reactor safety analysis  

SciTech Connect

This paper describes a family of three computer graphics codes designed to assist the analyst in three areas: the modelling of complex three-dimensional finite element models of reactor structures; the interpretation of computational results; and the reporting of the results of numerical simulations. The purpose and key features of each code are presented. The graphics output used in actual safety analysis are used to illustrate the capabilities of each code. 5 refs., 10 figs.

Fiala, C.; Kulak, R.F.

1989-01-01

76

Safety analysis report 306-W Building  

SciTech Connect

The west portion of the 306 building (306-W), which is operated by PNL, contains a diversified metalworking facility, the BNW specialty shop that machines U, Th, and other weakly radioactive materials, a ceramics laboratory, SNM storage area, and support laboratories, This report presents a safety analysis of the work performed and of the equipment in 306-W. the analyses cover criticality and radiological accidents as well as industrial accidents that could contribute to a criticality or radiological accident. (DLC)

Hays, D.D.; Lanning, D.D.; Anthis, R.M.; Nelson, R.G.

1979-01-01

77

Lunar lava tube radiation safety analysis  

NASA Technical Reports Server (NTRS)

For many years it has been suggested that lava tubes on the Moon could provide an ideal location for a manned lunar base, by providing shelter from various natural hazards, such as cosmic radiation, meteorites, micrometeoroids, and impact crater ejecta, and also providing a natural environmental control, with a nearly constant temperature, unlike that of the lunar surface showing extreme variation in its diurnal cycle. An analysis of radiation safety issues on lunar lava tubes has been performed by considering radiation from galactic cosmic rays (GCR) and Solar Particle Events (SPE) interacting with the lunar surface, modeled as a regolith layer and rock. The chemical composition has been chosen as typical of the lunar regions where the largest number of lava tube candidates are found. Particles have been transported all through the regolith and the rock, and received particles flux and doses have been calculated. The radiation safety of lunar lava tubes environments has been demonstrated.

De Angelis, Giovanni; Wilson, J. W.; Clowdsley, M. S.; Nealy, J. E.; Humes, D. H.; Clem, J. M.

2002-01-01

78

EXTENDING SAFETY DEVIATION ANALYSIS TECHNIQUES TO ELICIT FLEXIBLE DEPENDABILITY REQUIREMENTS  

E-print Network

EXTENDING SAFETY DEVIATION ANALYSIS TECHNIQUES TO ELICIT FLEXIBLE DEPENDABILITY REQUIREMENTS G dependability levels for the system. Elicitation of the requirements that define the levels of the dependability how we can extend existing safety techniques to elicit dependability requirements. Well established

Kelly, Tim

79

Efficiency analysis & safety assessment of automatic testing for safety-critical software [railway control  

Microsoft Academic Search

In order to ensure the quality of safety-critical software in the field of railway safety control and protection, safety test and assessment are of great importance besides functional test. The system structure and application of a testing and assessment platform for railway computer or microprocessor interlocking software are described in this paper. Sufficient testing data and its analysis are presented

Fangmei Wu; Lei Huang

2003-01-01

80

Axial compression behavior and partial composite action of SC walls in safety-related nuclear facilities  

NASA Astrophysics Data System (ADS)

Steel-plate reinforced concrete (SC) composite walls typically consist of thick concrete walls with two exterior steel faceplates. The concrete core is sandwiched between the two steel faceplates, and the faceplates are attached to the concrete core using shear connectors, for example, ASTM A108 steel headed shear studs. The shear connectors and the concrete infill enhance the stability of the steel faceplates, and the faceplates serve as permanent formwork for concrete placement. SC composite walls were first introduced in the 1980's in Japan for nuclear power plant (NPP) structures. They are used in the new generation of nuclear power plants (GIII+) and being considered for small modular reactors (SMR) due to their structural efficiency, economy, safety, and construction speed. Steel faceplates can potentially undergo local buckling at certain locations of NPP structures where compressive forces are significant. The steel faceplates are usually thin (0.25 to 1.50 inches in Customary units, or 6.5 to 38 mm in SI units) to maintain economical and constructional efficiency, the geometric imperfections and locked-in stresses induced during construction make them more vulnerable to local buckling. Accidental thermal loading may also reduce the compressive strength and exacerbate the local buckling potential of SC composite walls. This dissertation presents the results from experimental and numerical investigations of the compressive behavior of SC composite walls at ambient and elevated temperatures. The results are used to establish a slenderness limit to prevent local buckling before yielding of the steel faceplates and to develop a design approach for calculating the compressive strength of SC composite walls with non-slender and slender steel faceplates at ambient and elevated temperatures. Composite action in SC walls is achieved by the embedment of shear connectors into the concrete core. The strength and stiffness of shear connectors govern the level of composite action. This level of partial composite action can influence the behavior and stiffness of SC composite walls. This dissertation presents numerical investigations of the level of partial composite action and its influence on the flexural stiffness of SC walls. The results are used to propose design criteria for steel headed shear studs, such as their size, spacing, and strength.

Zhang, Kai

81

Rankine bottoming cycle safety analysis. Final report  

SciTech Connect

Vector Engineering Inc. conducted a safety and hazards analysis of three Rankine Bottoming Cycle Systems in public utility applications: a Thermo Electron system using Fluorinal-85 (a mixture of 85 mole % trifluoroethanol and 15 mole % water) as the working fluid; a Sundstrand system using toluene as the working fluid; and a Mechanical Technology system using steam and Freon-II as the working fluids. The properties of the working fluids considered are flammability, toxicity, and degradation, and the risks to both plant workers and the community at large are analyzed.

Lewandowski, G.A.

1980-02-01

82

ESSAA: Embedded system safety analysis assistant  

NASA Technical Reports Server (NTRS)

The Embedded System Safety Analysis Assistant (ESSAA) is a knowledge-based tool that can assist in identifying disaster scenarios. Imbedded software issues hazardous control commands to the surrounding hardware. ESSAA is intended to work from outputs to inputs, as a complement to simulation and verification methods. Rather than treating the software in isolation, it examines the context in which the software is to be deployed. Given a specified disasterous outcome, ESSAA works from a qualitative, abstract model of the complete system to infer sets of environmental conditions and/or failures that could cause a disasterous outcome. The scenarios can then be examined in depth for plausibility using existing techniques.

Wallace, Peter; Holzer, Joseph; Guarro, Sergio; Hyatt, Larry

1987-01-01

83

A New Pion-Nucleon Partial Wave Analysis  

NASA Astrophysics Data System (ADS)

Existing determinations of the masses, widths and decay modes of low-lying excited states of the nucleon, as compiled in the Review of Particle Physics, are determined from energy-independent partial wave analyses of pion-nucleon scattering data. For the N*(1440) and most other resonances under 2 GeV, the analyses cited are the Karlsruhe-Helsinki, Carnegie Mellon-Berkeley and Kent State analyses, the latter of which used the elastic amplitudes from the other two. The data included in these analyses were published before 1980. Other analyses, notably the recent ones from George Washington University and the Pittsburgh-Argonne group, are ``not used for averages, fits, limits, etc.'' Complete sets of measurements (differential cross sections, analyzing powers and spin rotation parameters) have been measured in the N*(1440) resonance region since 1980, culminating in the Crystal Ball program at BNL to measure all-neutral final states (charge exchange, multiple pi-zero final states, and inverse photoproduction). A new partial wave analysis of the Karlsruhe-Helsinki type has been started by Abilene Christian University, University of Tuzla, and Rudjer Boskovic Institute. The analysis is constrained by fixed-t and interior hyperbolic dispersion relations. Comparisons of the new analysis to modern experimental data and to previous analyses will be presented.

Sadler, Michael; Watson, Shon; Stahov, Jugoslav

2006-10-01

84

Partial wave analysis of J\\/psi-->pp¯pi0  

Microsoft Academic Search

Using a sample of 58 million J\\/psi events collected with the BESII detector at the BEPC, more than 100 000 J\\/psi-->pp¯pi0 events are selected, and a detailed partial wave analysis is performed. The branching fraction is determined to be Br(J\\/psi-->pp¯pi0)=(1.33±0.02±0.11)×10-3. A long-sought missing N*, first observed in J\\/psi-->pn¯pi-, is observed in this decay too, with mass and width of 2040-4+3±25MeV\\/c2

M. Ablikim; J. Z. Bai; Y. Bai; Y. Ban; X. Cai; H. F. Chen; H. S. Chen; H. X. Chen; J. C. Chen; X. D. Chen; Y. B. Chen; Y. P. Chu; Y. S. Dai; Z. Y. Deng; S. X. Du; J. Fang; C. D. Fu; C. S. Gao; Y. N. Gao; S. D. Gu; Y. T. Gu; Y. N. Guo; Z. J. Guo; F. A. Harris; K. L. He; M. He; Y. K. Heng; H. M. Hu; T. Hu; G. S. Huang; X. T. Huang; Y. P. Huang; X. B. Ji; X. S. Jiang; J. B. Jiao; D. P. Jin; S. Jin; G. Li; H. B. Li; J. Li; L. Li; R. Y. Li; S. M. Li; W. D. Li; W. G. Li; X. L. Li; X. N. Li; X. Q. Li; Y. F. Liang; B. J. Liu; C. X. Liu; Fang Liu; Feng Liu; H. M. Liu; J. P. Liu; H. B. Liu; Q. Liu; R. G. Liu; S. Liu; Z. A. Liu; F. Lu; G. R. Lu; J. G. Lu; C. L. Luo; F. C. Ma; H. L. Ma; Q. M. Ma; M. Q. A. Malik; Z. P. Mao; X. H. Mo; J. Nie; S. L. Olsen; R. G. Ping; N. D. Qi; J. F. Qiu; G. Rong; X. D. Ruan; L. Y. Shan; L. Shang; C. P. Shen; X. Y. Shen; H. Y. Sheng; H. S. Sun; S. S. Sun; Y. Z. Sun; Z. J. Sun; X. Tang; J. P. Tian; G. L. Tong; G. S. Varner; X. Wan; J. X. Wang; L. Wang; P. Wang; Y. F. Wang; Z. Wang; C. L. Wei; D. H. Wei; N. Wu; X. M. Xia; G. F. Xu; X. P. Xu; Y. Xu; M. L. Yan; H. X. Yang; M. Yang; Y. X. Yang; M. H. Ye; Y. X. Ye; C. X. Yu; C. Z. Yuan; Y. Yuan; Y. Zeng; B. X. Zhang; C. C. Zhang; D. H. Zhang; F. Zhang; H. Q. Zhang; H. Y. Zhang; J. W. Zhang; J. Y. Zhang; X. Y. Zhang; Y. Y. Zhang; Z. X. Zhang; Z. P. Zhang; D. X. Zhao; J. W. Zhao; M. G. Zhao; P. P. Zhao; Z. G. Zhao; B. Zheng; H. Q. Zheng; J. P. Zheng; Z. P. Zheng; B. Zhong; L. Zhou; K. J. Zhu; Q. M. Zhu; X. W. Zhu; Y. S. Zhu; Z. A. Zhu; Z. L. Zhu; B. A. Zhuang; B. S. Zou

2009-01-01

85

Partial wave analysis of J\\/psi-->gammavarphivarphi  

Microsoft Academic Search

Using 5.8×10J\\/psi events collected in the BESII detector, the radiative decay J\\/psi-->gammavarphivarphi-->gammaKKKS0KL0 is studied. The varphivarphi invariant mass distribution exhibits a near-threshold enhancement that peaks around 2.24 GeV\\/c. A partial wave analysis shows that the structure is dominated by a 0 state (eta(2225)) with a mass of 2.24-0.02+0.03-0.02+0.03 GeV\\/c and a width of 0.19±0.03-0.04+0.06 GeV\\/c. The product branching fraction is:

M. Ablikim; J. Z. Bai; Y. Bai; Y. Ban; X. Cai; H. F. Chen; H. S. Chen; H. X. Chen; J. C. Chen; X. D. Chen; Y. B. Chen; Y. P. Chu; Y. S. Dai; Z. Y. Deng; S. X. Du; J. Fang; C. D. Fu; C. S. Gao; Y. N. Gao; S. D. Gu; Y. T. Gu; Y. N. Guo; Z. J. Guo; F. A. Harris; K. L. He; M. He; Y. K. Heng; J. Hou; H. M. Hu; T. Hu; G. S. Huang; X. T. Huang; Y. P. Huang; X. B. Ji; X. S. Jiang; J. B. Jiao; D. P. Jin; S. Jin; Y. F. Lai; H. B. Li; J. Li; R. Y. Li; W. D. Li; W. G. Li; X. L. Li; X. N. Li; X. Q. Li; Y. F. Liang; H. B. Liao; B. J. Liu; C. X. Liu; Fang Liu; Feng Liu; H. H. Liu; H. M. Liu; J. B. Liu; J. P. Liu; H. B. Liu; Q. Liu; R. G. Liu; S. Liu; Z. A. Liu; F. Lu; G. R. Lu; J. G. Lu; C. L. Luo; F. C. Ma; H. L. Ma; L. L. Ma; Q. M. Ma; M. Q. A. Malik; Z. P. Mao; X. H. Mo; J. Nie; S. L. Olsen; R. G. Ping; N. D. Qi; H. Qin; J. F. Qiu; G. Rong; X. D. Ruan; L. Y. Shan; L. Shang; C. P. Shen; D. L. Shen; X. Y. Shen; H. Y. Sheng; H. S. Sun; S. S. Sun; Y. Z. Sun; Z. J. Sun; X. Tang; J. P. Tian; G. L. Tong; G. S. Varner; X. Wan; L. Wang; L. S. Wang; P. Wang; W. F. Wang; Y. F. Wang; Z. Wang; C. L. Wei; D. H. Wei; Y. Weng; N. Wu; X. M. Xia; X. X. Xie; G. F. Xu; X. P. Xu; Y. Xu; M. L. Yan; H. X. Yang; M. Yang; Y. X. Yang; M. H. Ye; Y. X. Ye; C. X. Yu; G. W. Yu; C. Z. Yuan; Y. Yuan; S. L. Zang; Y. Zeng; B. X. Zhang; C. C. Zhang; D. H. Zhang; H. Q. Zhang; H. Y. Zhang; J. W. Zhang; J. Y. Zhang; X. Y. Zhang; Y. Y. Zhang; Z. X. Zhang; Z. P. Zhang; D. X. Zhao; J. W. Zhao; M. G. Zhao; P. P. Zhao; Z. G. Zhao; H. Q. Zheng; J. P. Zheng; Z. P. Zheng; B. Zhong; L. Zhou; K. J. Zhu; Q. M. Zhu; X. W. Zhu; Y. C. Zhu; Y. S. Zhu; Z. A. Zhu; Z. L. Zhu; B. A. Zhuang; B. S. Zou

2008-01-01

86

242-A evaporator safety analysis report  

SciTech Connect

This report provides a revised safety analysis for the upgraded 242-A Evaporator (the Evaporator). This safety analysis report (SAR) supports the operation of the Evaporator following life extension upgrades and other facility and operations upgrades (e.g., Project B-534) that were undertaken to enhance the capabilities of the Evaporator. The Evaporator has been classified as a moderate-hazard facility (Johnson 1990). The information contained in this SAR is based on information provided by 242-A Evaporator Operations, Westinghouse Hanford Company, site maintenance and operations contractor from June 1987 to October 1996, and the existing operating contractor, Waste Management Hanford (WMH) policies. Where appropriate, a discussion address the US Department of Energy (DOE) Orders applicable to a topic is provided. Operation of the facility will be compared to the operating contractor procedures using appropriate audits and appraisals. The following subsections provide introductory and background information, including a general description of the Evaporator facility and process, a description of the scope of this SAR revision,a nd a description of the basic changes made to the original SAR.

CAMPBELL, T.A.

1999-05-17

87

Improved Range Safety Analysis for Space Vehicles Using Range Safety Template Toolkit  

NASA Astrophysics Data System (ADS)

This paper discusses an alternative to traditional methodologies for space launch and re-entry vehicle range safety analysis using the Range Safety Template Toolkit (RSTT), developed by Australia's Defense Science and Technology Organization (DSTO) in partnership with Aerospace Concepts Pty Ltd. RSTT offers rapid generation of mission-specific safety templates that comply with internationally-recognized standards for range risk criteria. Compared to some traditional methods, RSTT produces more accurate assessments of risk to personnel and infrastructure. This provides range operators with greater confidence in the range safety products, enhancing their ability to rigorously manage safety on their ranges. RSTT also offers increased precision of risk analysis and iteration of mission design allowing greater flexibility in planning range operations with rapid feedback on the safety impact of mission changes. These concepts are explored through examples involving a suborbital sounding rocket, demonstrating how traditional range safety assumptions may be reassessed using the RSTT robust probabilistic methodology.

Tisato, J.; Vuletich, I.; Brett, M.; Williams, W.; Wilson, S.

2012-01-01

88

C/C++ Thread Safety Analysis DeLesley Hutchins  

E-print Network

C/C++ Thread Safety Analysis DeLesley Hutchins Google Inc. Email: delesley@google.com Aaron Ballman--Writing multithreaded programs is hard. Static analysis tools can help developers by allowing threading policies, and can detect potential race conditions and deadlocks. This paper describes Clang Thread Safety Analysis

Cortes, Corinna

89

Information Services at the Nuclear Safety Analysis Center.  

ERIC Educational Resources Information Center

This paper describes the operations of the Nuclear Safety Analysis Center. Established soon after an accident at the Three Mile Island nuclear power plant near Harrisburg, Pennsylvania, its efforts were initially directed towards a detailed analysis of the accident. Continuing functions include: (1) the analysis of generic nuclear safety issues,…

Simard, Ronald

90

Partial differential equations and fractal analysis to plant leaf identification  

NASA Astrophysics Data System (ADS)

Texture is an important visual attribute used to plant leaf identification. Although there are many methods of texture analysis, some of them specifically for interpreting leaf images is still a challenging task because of the huge pattern variation found in nature. In this paper, we investigate the leaf texture modeling based on the partial differential equations and fractal dimension theory. Here, we are first interested in decomposing the original texture image into two components f = u + v, such that u represents a cartoon component, while v represents the oscillatory component. We demonstrate how this procedure enhance the texture component on images. Our modeling uses the non-linear partial differential equation (PDE) of Perona-Malik. Based on the enhanced texture component, we estimated the fractal dimension by the Bouligand-Minkowski method due to its precision in quantifying structural properties of images. The feature vectors are then used as inputs to our classification system, based on linear discriminant analysis. We validate our approach on a benchmark with 8000 leaf samples. Experimental results indicate that the proposed approach improves average classification rates in comparison with traditional methods. The results suggest that the proposed approach can be a feasible step for plant leaf identification, as well as different real-world applications.

Brandoli Machado, Bruno; Casanova, Dalcimar; Nunes Gonçalves, Wesley; Martinez Bruno, Odemir

2013-02-01

91

Safety Evaluation Report of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis  

SciTech Connect

This Safety Evaluation Report (SER) documents the Department of Energy’s (DOE's) review of Revision 9 of the Waste Isolation Pilot Plant Contact Handled (CH) Waste Documented Safety Analysis, DOE/WIPP-95-2065 (WIPP CH DSA), and provides the DOE Approval Authority with the basis for approving the document. It concludes that the safety basis documented in the WIPP CH DSA is comprehensive, correct, and commensurate with hazards associated with CH waste disposal operations. The WIPP CH DSA and associated technical safety requirements (TSRs) were developed in accordance with 10 CFR 830, Nuclear Safety Management, and DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Safety Analysis Reports.

Washington TRU Solutions LLC

2005-09-01

92

Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age  

PubMed Central

Epilepsy is a common neurological disorder in the pediatric population, affecting up to one percent of children, and for which the mainstay of treatment is anticonvulsant medication. Despite the frequent use of anticonvulsant drugs, remarkably little is known about the safety and efficacy of most of these medications in the pediatric epilepsy population. Of 34 anticonvulsants currently approved for use by the US Food and Drug Administration (FDA), only 13 have been approved for use in children. Although infants and young children are disproportionately affected by epilepsy, there are currently only three anticonvulsant medications that have been specifically evaluated and approved for use in children younger than 2 years of age. In 2012, the FDA approved levetiracetam as an adjunctive treatment for partial onset seizures in infants and children from one month of age. Here we review the available data on levetiracetam in the pediatric epilepsy population. We first discuss the pharmacological profile of levetiracetam, including its mechanism of action, formulations and dosing, and pharmacokinetics in children. We then review the available efficacy, safety, and tolerability data in children from one month of age with partial onset seizures. We conclude that the current data leading to the approval of levetiracetam for use in infants and children with partial onset seizures is encouraging, although more work needs to be done before definitive conclusions can be drawn about the efficacy of levetiracetam across different pediatric age groups. PMID:23458993

Cormier, Justine; Chu, Catherine J

2013-01-01

93

Integrated safety analysis of software-controlled critical systems  

Microsoft Academic Search

Software for safety-critical systems must deal with the hazards identified by safety analysis in order to make the system safe, risk-free and fail-safe. Certain faults in critical systems can result in catastrophic consequences such as death, injury or environmental harm. The focus of this paper is an integrated approach to software safety analysis based on a combination of two existing

Ben Swarup Medikonda; P. Seetha Ramaiah

2010-01-01

94

An analysis of several partially adaptive beamformer designs  

NASA Astrophysics Data System (ADS)

A general analysis of broadband interference cancellation in adaptive beamformers is provided. The results are then used to analyze beam, eigenstructure, and power-minimization approaches to the design of linearly constrained partially adaptive beamformers. It is shown that although beam-based designs are capable of good performance in narrowband environments, they are not appropriate for broadband environments. Eigenstructure-based designs are capable of excellent performance in narrow- or broadband environments. However, performance degrades if the number of adaptive weights is less than the eigenstructure dimension. Power-minimization designs are based on directly minimizing interference output power. Simulations indicate that the power-minimization design is capable of the best cancellation performance with a limited number of adaptive weights.

van Veen, Barry D.

1989-02-01

95

Final report for confinement vessel analysis. Task 2, Safety vessel impact analyses  

SciTech Connect

This report describes two sets of finite element analyses performed under Task 2 of the Confinement Vessel Analysis Program. In each set of analyses, a charge is assumed to have detonated inside the confinement vessel, causing the confinement vessel to fail in either of two ways; locally around the weld line of a nozzle, or catastrophically into two hemispheres. High pressure gases from the internal detonation pressurize the inside of the safety vessel and accelerate the fractured nozzle or hemisphere into the safety vessel. The first set of analyses examines the structural integrity of the safety vessel when impacted by the fractured nozzle. The objective of these calculations is to determine if the high strength bolt heads attached to the nozzle penetrate or fracture the lower strength safety vessel, thus allowing gaseous detonation products to escape to the atmosphere. The two dimensional analyses predict partial penetration of the safety vessel beneath the tip of the penetrator. The analyses also predict maximum principal strains in the safety vessel which exceed the measured ultimate strain of steel. The second set of analyses examines the containment capability of the safety vessel closure when impacted by half a confinement vessel (hemisphere). The predicted response is the formation of a 0.6-inch gap, caused by relative sliding and separation between the two halves of the safety vessel. Additional analyses with closure designs that prevent the gap formation are recommended.

Murray, Y.D. [APTEK, Inc., Colorado Springs, CO (United States)

1994-01-26

96

Safety analysis of the nuclear chemistry Building 151  

SciTech Connect

This report summarizes the results of a safety analysis that was done on Building 151. The report outlines the methodology, the analysis, and the findings that led to the low hazard classification. No further safety evaluation is indicated at this time. 5 tables.

Kvam, D.

1984-06-29

97

Safety analysis, risk assessment, and risk acceptance criteria  

Microsoft Academic Search

This paper discusses a number of topics that relate safety analysis as documented in the Department of Energy (DOE) safety analysis reports (SARs), probabilistic risk assessments (PRA) as characterized primarily in the context of the techniques that have assumed some level of formality in commercial nuclear power plant applications, and risk acceptance criteria as an outgrowth of PRA applications. DOE

K. Jamali; D. W. Stack; L. H. Sullivan; D. L. Sanzo

1997-01-01

98

Preliminary Safety Analysis of the Gorleben Site: Overview - 13298  

SciTech Connect

The project preliminary safety analysis of the Gorleben site started in 2010 and is based on the safety requirements for heat generating radioactive waste released from the German Federal Ministry for Environment, natural conservation and nuclear safety. The project consists of several tasks: the database defining the geology of Gorleben and the composition of the waste to be disposed of, the safety and demonstration concept, the repository concepts, the scenario analysis, the system analysis with long-term safety assessment and the synthesis. The overall synthesis indicates presently the compatibility of a repository in Gorleben with the safety requirements. The application of the method for a site selection process is still under evaluation. (authors)

Bracke, G.; Fischer-Appelt, K. [GRS mbH, Schwertnergasse 1, 50677 Cologne (Germany)] [GRS mbH, Schwertnergasse 1, 50677 Cologne (Germany); Baltes, B. [B. Baltes, Paul Kaussen Str. 17a, 52477 Alsdorf (Germany)] [B. Baltes, Paul Kaussen Str. 17a, 52477 Alsdorf (Germany)

2013-07-01

99

Aggregate nonparametric safety analysis of traffic zones.  

PubMed

Exploring the significant variables related to specific types of crashes is vitally important in the planning stage of a transportation network. This paper aims to identify and examine important variables associated with total crashes and severe crashes per traffic analysis zone (TAZ) in four counties of the state of Florida by applying nonparametric statistical techniques such as data mining and random forest. The intention of investigating these factors in such aggregate level analysis is to incorporate proactive safety measures in transportation planning. Total and severe crashes per TAZ were modeled to provide predictive decision trees. The variables which carried higher weight of importance for total crashes per TAZ were - total number of intersections per TAZ, airport trip productions, light truck productions, and total roadway segment length with 35 mph posted speed limit. The other significant variables identified for total crashes were total roadway length with 15 mph posted speed limit, total roadway length with 65 mph posted speed limit, and non-home based work productions. For severe crashes, total number of intersections per TAZ, light truck productions, total roadway length with 35 mph posted speed limit, and total roadway length with 65 mph posted speed limit were among the significant variables. These variables were further verified and supported by the random forest results. PMID:22269515

Siddiqui, Chowdhury; Abdel-Aty, Mohamed; Huang, Helai

2012-03-01

100

Proteomic analysis of regenerating mouse liver following 50% partial hepatectomy  

PubMed Central

Background Although 70% (or 2/3) partial hepatectomy (PH) is the most studied model for liver regeneration, the hepatic protein expression profile associated with lower volume liver resection (such as 50% PH) has not yet been reported. Therefore, the aim of this study was to determine the global protein expression profile of the regenerating mouse liver following 50% PH by differential proteomics, and thereby gaining some insights into the hepatic regeneration mechanism(s) under this milder but clinically more relevant condition. Results Proteins from sham-operated mouse livers and livers regenerating for 24 h after 50% PH were separated by SDS-PAGE and analyzed by nanoUPLC-Q-Tof mass spectrometry. Compared to sham-operated group, there were totally 87 differentially expressed proteins (with 50 up-regulated and 37 down-regulated ones) identified in the regenerating mouse livers, most of which have not been previously related to liver regeneration. Remarkably, over 25 differentially expressed proteins were located at mitochondria. Several of the mitochondria-resident proteins which play important roles in citric acid cycle, oxidative phosphorylation and ATP production were found to be down-regulated, consistent with the recently-proposed model in which the reduction of ATP content in the remnant liver gives rise to early stress signals that contribute to the onset of liver regeneration. Pathway analysis revealed a central role of c-Myc in the regulation of liver regeneration. Conclusions Our study provides novel evidence for mitochondria as a pivotal organelle that is connected to liver regeneration, and lays the foundation for further studies on key factors and pathways involved in liver regeneration following 50% PH, a condition frequently used for partial liver transplantation and conservative liver resection. PMID:20040084

2009-01-01

101

Partial inhibition and bilevel optimization in flux balance analysis  

PubMed Central

Motivation Within Flux Balance Analysis, the investigation of complex subtasks, such as finding the optimal perturbation of the network or finding an optimal combination of drugs, often requires to set up a bilevel optimization problem. In order to keep the linearity and convexity of these nested optimization problems, an ON/OFF description of the effect of the perturbation (i.e. Boolean variable) is normally used. This restriction may not be realistic when one wants, for instance, to describe the partial inhibition of a reaction induced by a drug. Results In this paper we present a formulation of the bilevel optimization which overcomes the oversimplified ON/OFF modeling while preserving the linear nature of the problem. A case study is considered: the search of the best multi-drug treatment which modulates an objective reaction and has the minimal perturbation on the whole network. The drug inhibition is described and modulated through a convex combination of a fixed number of Boolean variables. The results obtained from the application of the algorithm to the core metabolism of E.coli highlight the possibility of finding a broader spectrum of drug combinations compared to a simple ON/OFF modeling. Conclusions The method we have presented is capable of treating partial inhibition inside a bilevel optimization, without loosing the linearity property, and with reasonable computational performances also on large metabolic networks. The more fine-graded representation of the perturbation allows to enlarge the repertoire of synergistic combination of drugs for tasks such as selective perturbation of cellular metabolism. This may encourage the use of the approach also for other cases in which a more realistic modeling is required. PMID:24286232

2013-01-01

102

The role of safety analysis in accident prevention.  

PubMed

The need for safety analysis has grown in the fields of nuclear industry, civil and military aviation and space technology where the potential for accidents with far-reaching consequences for employees, the public and the environment is most apparent. Later the use of safety analysis has spread widely to other industrial branches. General systems theory, accident theories and scientific management represent domains that have influenced the development of safety analysis. These relations are shortly presented and the common methods employed in safety analysis are described and structured according to the aim of the search and to the search strategy. A framework for the evaluation of the coverage of the search procedures employed in different methods of safety analysis is presented. The framework is then used in an heuristic and in an empiric evaluation of hazard and operability study (HAZOP), work safety analysis (WSA), action error analysis (AEA) and management oversight and risk tree (MORT). Finally, some recommendations on the use of safety analysis for preventing accidents are presented. PMID:3337767

Suokas, J

1988-02-01

103

The quality/safety medical index: implementation and analysis.  

PubMed

Medical analytics relating to quality and safety measures have become particularly timely and of high importance in contemporary medical practice. In medical imaging, the dynamic relationship between medical imaging quality and radiation safety creates challenges in quantifying quality or safety independently. By creating a standardized measurement which simultaneously accounts for quality and safety measures (i.e., quality safety index), one can in theory create a standardized method for combined quality and safety analysis, which in turn can be analyzed in the context of individual patient, exam, and clinical profiles. The derived index measures can be entered into a centralized database, which in turn can be used for comparative performance of individual and institutional service providers. In addition, data analytics can be used to create customizable educational resources for providers and patients, clinical decision support tools, technology performance analysis, and clinical/economic outcomes research. PMID:25416467

Reiner, Bruce I

2015-02-01

104

A safety analysis of warhead balancing  

SciTech Connect

Reentry vehicles (RVs) carrying warheads from ballistic missiles must be carefully balanced with the warhead in situ to prevent wobble as the RVs enter the earth`s atmosphere to prevent inaccuracy or loss of the warhead. This balancing is performed on a dynamic balancing machine that rotates the RV at significant angular velocities. Seizure of the spindle shaft of the machine could result in rapid deceleration of the rotating assembly, which could over-stress and shear bolts or other structures that attach the RV to the balancing machine. This could result in undesired motions of the RV and impact of the RV on equipment or structures in the work area. This potential safety problem has long been recognized in a general way, but no systematic investigation of the possible accident sequences had been performed. The purpose of this paper is to describe an integrated set of systems analysis techniques that worked well in developing a set of accident sequences that describe the motions of the RV following a spindle-shaft seizure event.

Bott, T.F.

1998-12-01

105

Safety analysis report for the Waste Storage Facility. Revision 2  

SciTech Connect

This safety analysis report outlines the safety concerns associated with the Waste Storage Facility located in the Radioactive Waste Management Complex at the Idaho National Engineering Laboratory. The three main objectives of the report are: define and document a safety basis for the Waste Storage Facility activities; demonstrate how the activities will be carried out to adequately protect the workers, public, and environment; and provide a basis for review and acceptance of the identified risk that the managers, operators, and owners will assume.

Bengston, S.J.

1994-05-01

106

PHYSICS AND SAFETY ANALYSIS FOR THE NIST RESEARCH REACTOR  

Microsoft Academic Search

Detailed reactor physics and safety analyses have been performed for the 20 MW DO moderated research reactor (NBSR) at the National Institute of Standards and Technology (NIST). The analyses provide an update to the Final Safety Analysis Report (FSAR) and employ state-of-the-art calculational methods. Three-dimensional MCNP Monte Carlo neutron and photon transport calculations were performed to determine the safety parameters

J. CHENG; L. HANSON; J. RORER; D. DIAMOND

2003-01-01

107

SNF fuel retrieval sub project safety analysis document  

SciTech Connect

This safety analysis is for the SNF Fuel Retrieval (FRS) Sub Project. The FRS equipment will be added to K West and K East Basins to facilitate retrieval, cleaning and repackaging the spent nuclear fuel into Multi-Canister Overpack baskets. The document includes a hazard evaluation, identifies bounding accidents, documents analyses of the accidents and establishes safety class or safety significant equipment to mitigate accidents as needed.

BERGMANN, D.W.

1999-02-24

108

Analysis of microgravity space experiments Space Shuttle programmatic safety requirements  

NASA Technical Reports Server (NTRS)

This report documents the results of an analysis of microgravity space experiments space shuttle programmatic safety requirements and recommends the creation of a Safety Compliance Data Package (SCDP) Template for both flight and ground processes. These templates detail the programmatic requirements necessary to produce a complete SCDP. The templates were developed from various NASA centers' requirement documents, previously written guidelines on safety data packages, and from personal experiences. The templates are included in the back as part of this report.

Terlep, Judith A.

1996-01-01

109

Biomechanical analysis of bursal-sided partial thickness rotator cuff tears  

E-print Network

Biomechanical analysis of bursal-sided partial thickness rotator cuff tears Scott Yang, BSa , Hyung of Shoulder and Elbow Surgery Board of Trustees. Keywords: Rotator cuff; rotator cuff tear; supraspinatus abductor of the arm, and is most commonly torn in partial thickness rotator cuff tears.8 Partial thickness

Makhsous, Mohsen

110

Safety analysis report 231-Z Building  

SciTech Connect

This report provides an intensive review of the nuclear safety of the operation of the 231-Z Building. For background information complete descriptions of the floor plan, building services, alarm systems, and glove box systems are included in this report. In addition, references are included to The Plutonium Laboratory Radiation Work Procedures, Safety Guides, 231-Z Operating Procedures Manual and Nuclear Materials accountability Procedures. Engineered and administrative features contribute to the overall safety of personnel, the building, and environs. The consequences of credible incidents were considered and are discussed.

Powers, C.S.

1989-03-01

111

Systems Analysis of NASA Aviation Safety Program: Final Report  

NASA Technical Reports Server (NTRS)

A three-month study (February to April 2010) of the NASA Aviation Safety (AvSafe) program was conducted. This study comprised three components: (1) a statistical analysis of currently available civilian subsonic aircraft data from the National Transportation Safety Board (NTSB), the Federal Aviation Administration (FAA), and the Aviation Safety Information Analysis and Sharing (ASIAS) system to identify any significant or overlooked aviation safety issues; (2) a high-level qualitative identification of future safety risks, with an assessment of the potential impact of the NASA AvSafe research on the National Airspace System (NAS) based on these risks; and (3) a detailed, top-down analysis of the NASA AvSafe program using an established and peer-reviewed systems analysis methodology. The statistical analysis identified the top aviation "tall poles" based on NTSB accident and FAA incident data from 1997 to 2006. A separate examination of medical helicopter accidents in the United States was also conducted. Multiple external sources were used to develop a compilation of ten "tall poles" in future safety issues/risks. The top-down analysis of the AvSafe was conducted by using a modification of the Gibson methodology. Of the 17 challenging safety issues that were identified, 11 were directly addressed by the AvSafe program research portfolio.

Jones, Sharon M.; Reveley, Mary S.; Withrow, Colleen A.; Evans, Joni K.; Barr, Lawrence; Leone, Karen

2013-01-01

112

Probabilistic safety analysis. Interim report 1. [PWR; BWR  

Microsoft Academic Search

This report summarizes work carried out during the first year of the Science Application, Inc. (SAI)\\/Electric Power Research Institute (EPRI) contract on LWR probabilistic safety analysis. A large amount of useful source material was provided by the draft report of the Reactor Safety Study (WASH-1400), and much of the SAI activity during the past year was based upon the Study's

Erdmann

1975-01-01

113

Partial differential equation transform — Variational formulation and Fourier analysis  

PubMed Central

Nonlinear partial differential equation (PDE) models are established approaches for image/signal processing, data analysis and surface construction. Most previous geometric PDEs are utilized as low-pass filters which give rise to image trend information. In an earlier work, we introduced mode decomposition evolution equations (MoDEEs), which behave like high-pass filters and are able to systematically provide intrinsic mode functions (IMFs) of signals and images. Due to their tunable time-frequency localization and perfect reconstruction, the operation of MoDEEs is called a PDE transform. By appropriate selection of PDE transform parameters, we can tune IMFs into trends, edges, textures, noise etc., which can be further utilized in the secondary processing for various purposes. This work introduces the variational formulation, performs the Fourier analysis, and conducts biomedical and biological applications of the proposed PDE transform. The variational formulation offers an algorithm to incorporate two image functions and two sets of low-pass PDE operators in the total energy functional. Two low-pass PDE operators have different signs, leading to energy disparity, while a coupling term, acting as a relative fidelity of two image functions, is introduced to reduce the disparity of two energy components. We construct variational PDE transforms by using Euler-Lagrange equation and artificial time propagation. Fourier analysis of a simplified PDE transform is presented to shed light on the filter properties of high order PDE transforms. Such an analysis also offers insight on the parameter selection of the PDE transform. The proposed PDE transform algorithm is validated by numerous benchmark tests. In one selected challenging example, we illustrate the ability of PDE transform to separate two adjacent frequencies of sin(x) and sin(1.1x). Such an ability is due to PDE transform’s controllable frequency localization obtained by adjusting the order of PDEs. The frequency selection is achieved either by diffusion coefficients or by propagation time. Finally, we explore a large number of practical applications to further demonstrate the utility of proposed PDE transform. PMID:22207904

Wang, Yang; Wei, Guo-Wei; Yang, Siyang

2011-01-01

114

Fracture Surface Analysis of Clinically Failed Fixed Partial Dentures  

Microsoft Academic Search

Ceramic systems have limited long-term fracture resistance, especially when they are used in posterior areas or for fixed partial dentures. The objective of this study was to determine the site of crack initiation and the causes of fracture of clinically failed ceramic fixed partial dentures. Six Empress 2® lithia-disilicate (Li2O·2SiO2)-based veneered bridges and 7 experimental lithia-disilicate-based non-veneered ceramic bridges were

B. Taskonak; J. J. Mecholsky; K. J. Anusavice

2006-01-01

115

Computational methods for criticality safety analysis within the scale system  

SciTech Connect

The criticality safety analysis capabilities within the SCALE system are centered around the Monte Carlo codes KENO IV and KENO V.a, which are both included in SCALE as functional modules. The XSDRNPM-S module is also an important tool within SCALE for obtaining multiplication factors for one-dimensional system models. This paper reviews the features and modeling capabilities of these codes along with their implementation within the Criticality Safety Analysis Sequences (CSAS) of SCALE. The CSAS modules provide automated cross-section processing and user-friendly input that allow criticality safety analyses to be done in an efficient and accurate manner. 14 refs., 2 figs., 3 tabs.

Parks, C.V.; Petrie, L.M.; Landers, N.F.; Bucholz, J.A.

1986-01-01

116

Galileo and Ulysses missions safety analysis and launch readiness status  

NASA Technical Reports Server (NTRS)

The Galileo spacecraft, which will release probes to explore the Jupiter system, was launched in October, 1989 as the payload on STS-34, and the Ulysses spacecraft, which will fly by Jupiter en route to a polar orbit of the sun, is presently entering system-test activity in preparation for an October, 1990 launch. This paper reviews the Galileo and Ulysses mission objectives and design approaches and presents details of the missions' safety analysis. The processes used to develop the safety analysis are described and the results of safety tests are presented.

Cork, M. Joseph; Turi, James A.

1989-01-01

117

A guide for performing system safety analysis  

NASA Technical Reports Server (NTRS)

A general guide is presented for performing system safety analyses of hardware, software, operations and human elements of an aerospace program. The guide describes a progression of activities that can be effectively applied to identify hazards to personnel and equipment during all periods of system development. The general process of performing safety analyses is described; setting forth in a logical order the information and data requirements, the analytical steps, and the results. These analyses are the technical basis of a system safety program. Although the guidance established by this document cannot replace human experience and judgement, it does provide a methodical approach to the identification of hazards and evaluation of risks to the system.

Brush, J. M.; Douglass, R. W., III.; Williamson, F. R.; Dorman, M. C. (editor)

1974-01-01

118

Solving a system of nonlinear fractional partial differential equations using homotopy analysis method  

NASA Astrophysics Data System (ADS)

In this article, the homotopy analysis method (HAM) has been employed to obtain solutions of a System of nonlinear fractional partial differential equations. This indicates the validity and great potential of the homotopy analysis method for solving system of fractional partial differential equations. The fractional derivative is described in the Caputo sense.

Jafari, H.; Seifi, S.

2009-05-01

119

Efficacy and safety of extended-release oxcarbazepine (Oxtellar XR™) as adjunctive therapy in patients with refractory partial-onset seizures: a randomized controlled trial  

PubMed Central

Objective To evaluate the efficacy, tolerability, and safety of once-daily 1200 mg and 2400 mg SPN-804 (Oxtellar XR™, Supernus Pharmaceuticals), an extended-release tablet formulation of oxcarbazepine (OXC), added to 1-3 concomitant antiepileptic drugs (AEDs) in adults with refractory partial-onset seizures, with or without secondary generalization. Methods The Prospective, Randomized Study of OXC XR in Subjects with Partial Epilepsy Refractory (PROSPER) study was a multinational, randomized, double-blind, parallel-group Phase 3 study. The primary efficacy endpoint was median percent reduction from baseline in monthly (28-day) seizure frequency for the 16-week double-blind treatment period in the intent-to-treat (ITT) population with analyzable seizure data. Other efficacy analyses included proportion of patients with ? 50% seizure reduction, proportion of patients seizure free, and the relationship between clinical response and plasma concentration. Results Median percent reduction was -28.7% for placebo, ?38.2% (P = 0.08 vs placebo) for once-daily SPN-804 1200 mg, and ?42.9% (P = 0.003) for SPN-804 2400 mg. Responder rates were 28.1%, 36.1% (P = 0.08), and 40.7% (P = 0.02); 16-week seizure-free rates in a pragmatic ITT analysis were 3.3%, 4.9% (P = 0.59), and 11.4% (P = 0.008), respectively. When data were analyzed separately for study site clusters, a post hoc analysis demonstrated that both SPN-804 dosages were significantly superior to placebo in median percent seizure reduction (placebo: ?13.3%; 1200 mg: ?34.5%, P = 0.02; 2400 mg: ?52.7%, P = 0.006) in the North American study site cluster. A concentration–response analysis also supported a clinically meaningful effect for 1200 mg. Adverse event types reflected the drug's established profile. Adverse event frequency was consistent with a pharmacokinetic profile in which SPN-804 produces lower peak plasma concentrations vs immediate-release OXC. Once-daily dosing was not associated with any new safety signals. Conclusions Adjunctive once-daily SPN-804 improved seizure control in patients with inadequately controlled partial-onset seizures. Adverse event occurrence and discontinuations due to adverse events suggest improved tolerability vs previously published data with immediate-release OXC. PMID:24359313

French, JA; Baroldi, P; Brittain, ST; Johnson, JK

2014-01-01

120

Demonstration of a Safety Analysis on a Complex System  

NASA Technical Reports Server (NTRS)

For the past 17 years, Professor Leveson and her graduate students have been developing a theoretical foundation for safety in complex systems and building a methodology upon that foundation. The methodology includes special management structures and procedures, system hazard analyses, software hazard analysis, requirements modeling and analysis for completeness and safety, special software design techniques including the design of human-machine interaction, verification, operational feedback, and change analysis. The Safeware methodology is based on system safety techniques that are extended to deal with software and human error. Automation is used to enhance our ability to cope with complex systems. Identification, classification, and evaluation of hazards is done using modeling and analysis. To be effective, the models and analysis tools must consider the hardware, software, and human components in these systems. They also need to include a variety of analysis techniques and orthogonal approaches: There exists no single safety analysis or evaluation technique that can handle all aspects of complex systems. Applying only one or two may make us feel satisfied, but will produce limited results. We report here on a demonstration, performed as part of a contract with NASA Langley Research Center, of the Safeware methodology on the Center-TRACON Automation System (CTAS) portion of the air traffic control (ATC) system and procedures currently employed at the Dallas/Fort Worth (DFW) TRACON (Terminal Radar Approach CONtrol). CTAS is an automated system to assist controllers in handling arrival traffic in the DFW area. Safety is a system property, not a component property, so our safety analysis considers the entire system and not simply the automated components. Because safety analysis of a complex system is an interdisciplinary effort, our team included system engineers, software engineers, human factors experts, and cognitive psychologists.

Leveson, Nancy; Alfaro, Liliana; Alvarado, Christine; Brown, Molly; Hunt, Earl B.; Jaffe, Matt; Joslyn, Susan; Pinnell, Denise; Reese, Jon; Samarziya, Jeffrey; Sandys, Sean; Shaw, Alan; Zabinsky, Zelda

1997-01-01

121

Westinghouse Hanford Company safety analysis reports and technical safety requirements upgrade program  

SciTech Connect

During Fiscal Year 1992, the US Department of Energy, Richland Operations Office (RL) separately transmitted the following US Department of Energy (DOE) Orders to Westinghouse Hanford Company (WHC) for compliance: DOE 5480.21, ``Unreviewed Safety Questions,`` DOE 5480.22, ``Technical Safety Requirements,`` and DOE 5480.23, ``Nuclear Safety Analysis Reports.`` WHC has proceeded with its impact assessment and implementation process for the Orders. The Orders are closely-related and contain some requirements that are either identical, similar, or logically-related. Consequently, WHC has developed a strategy calling for an integrated implementation of the three Orders. The strategy is comprised of three primary objectives, namely: Obtain DOE approval of a single list of DOE-owned and WHC-managed Nuclear Facilities, Establish and/or upgrade the ``Safety Basis`` for each Nuclear Facility, and Establish a functional Unreviewed Safety Question (USQ) process to govern the management and preservation of the Safety Basis for each Nuclear Facility. WHC has developed policy-revision and facility-specific implementation plans to accomplish near-term tasks associated with the above strategic objectives. This plan, which as originally submitted in August 1993 and approved, provided an interpretation of the new DOE Nuclear Facility definition and an initial list of WHC-managed Nuclear Facilities. For each current existing Nuclear Facility, existing Safety Basis documents are identified and the plan/status is provided for the ISB. Plans for upgrading SARs and developing TSRs will be provided after issuance of the corresponding Rules.

Busche, D.M.

1995-09-01

122

Thermo-hydro-mechanical analysis of partially saturated porous materials  

Microsoft Academic Search

Presents a fully coupled numerical model to simulate the slow transient phenomena involving heat and mass transfer in deforming partially saturated porous materials. Makes use of the modified effective stress concept together with the capillary pressure relationship. Examines phase changes (evaporation-condensation(, heat transfer through conduction and convection, as well as latent heat transfer. The governing equations in terms of gas

Dariusz Gawin; Bernhard A. Schrefler; M. Galindo

1996-01-01

123

Multilevel Analysis Methods for Partially Nested Cluster Randomized Trials  

ERIC Educational Resources Information Center

This paper explores multilevel modeling approaches for 2-group randomized experiments in which a treatment condition involving clusters of individuals is compared to a control condition involving only ungrouped individuals, otherwise known as partially nested cluster randomized designs (PNCRTs). Strategies for comparing groups from a PNCRT in the…

Sanders, Elizabeth A.

2011-01-01

124

Finite element analysis of lumbosacral reconstruction after partial sacrectomy  

PubMed Central

Background The biomechanical property of MGT for patients who underwent partial sacrectomy is not well documented, so this study aimed to investigate biomechanical property of lumbosacral reconstruction after partial sacrectomy. Material/Methods Three 3-dimensional finite element models of lumbosacral region were established: 1) an intact model (INT), 2) a defective model in which partial sacrectomy was performed cephalad to S1 foramina (DEF), and 3) a reconstructed model (REC). Results Displacements of anchor point on L3 vertebrae in INT, DEF, and REC model were 6.63 mm, 10.62 mm, 4.29 mm (titanium), and 3.86mm (stainless steel), respectively. Stress distribution of the instrument in REC model showed excessive concentration on the caudal spinal rod, which may cause rod failure between spine and ilia. Maximum von Mise stress of the stainless steel instrument was higher than titanium instruments, and values of stress of the anchor point around the sacroiliac joint in the REC model were 26.4MPa with titanium instruments and 23.9 MPa with stainless steel instruments. Conclusions Lumbosacral reconstruction can significantly increase stiffness of the spinopelvis of patients who underwent partial sacrectomy. However, the rod between L5 and ilia is the weakest region of all instruments. Stainless steel instruments have higher risk of rod failure and are less suitable for lumboiliac arthrodesis than titanium instruments. PMID:24874025

Zheng, Longpo; Li, Ziqiang; Li, Quan; Ji, Fang; Cai, Zhengdong

2014-01-01

125

Safety analysis approaches or mixed transuranic waste.  

SciTech Connect

Argonne National Laboratory (ANL) has completed a survey of assumptions and techniques used for safety analyses at seven sites that handle or store mixed transuranic (TRU) waste operated by contractors for the US Department of Energy (DOE). While approaches to estimating on-site and off-site consequences of hypothetical accidents differ, there are commonalities in all of the safety studies. This paper identifies key parameters and methods used to estimate the radiological consequences associated with release of waste forms under abnormal conditions. Specific facilities are identified by letters with their safety studies listed in a bibliography rather than as specific references so that similarities and differences are emphasized in a nonjudgmental manner. References are provided for specific parameters used to project consequences associated with compromise of barriers and dispersion of potentially hazardous materials. For all of the accidents and sites, estimated dose commitments are well below guidelines even using highly conservative assumptions. Some of the studies quantified the airborne concentrations of toxic materials; this paper only addresses these analyses briefly, as an entire paper could be dedicated to this subject.

Courtney, J. C.; Dwight, C. C.; Forrester, R. J.; Lehto, M. A.; Pan, Y. C.

1999-02-10

126

Preliminary Integrated Safety Analysis of Synthetic Vision Conducted  

NASA Technical Reports Server (NTRS)

The goal of the NASA Aviation Safety Program is to develop and demonstrate technologies that could help reduce the aviation fatal accident rate by a factor of 5 by the year 2007 and by a factor of 10 by the year 2022. Integrated safety analysis of day-to-day operations and risks within those operations will provide an understanding of the Aviation Safety Program portfolio beyond what is now available. Synthetic vision is the first of the Aviation Safety Program technologies that has been analyzed by the Logistics Management Institute under a contract with the NASA Glenn Research Center. These synthetic vision analyses include both a reliability analysis and a computer simulation model.

Reveley, Mary S.

2002-01-01

127

PHYSICS AND SAFETY ANALYSIS FOR THE NIST RESEARCH REACTOR  

Microsoft Academic Search

Detailed reactor physics and safety analyses have been performed for the 20 MW DO moderated research reactor (NBSR) at the National Institute of Standards and Technology (NIST). The analyses provide an update to the Final Safety Analysis Report (FSAR) and employ state-of-the-art calculational methods. Three-dimensional Monte Carlo neutron and photon transport calculations were performed with the MCNP code to determine

L. HANSON; A. DIAMOND; D. XU; J. CAREW; J. RORER

2004-01-01

128

Software Safety Analysis of a Flight Guidance System  

NASA Technical Reports Server (NTRS)

This document summarizes the safety analysis performed on a Flight Guidance System (FGS) requirements model. In particular, the safety properties desired of the FGS model are identified and the presence of the safety properties in the model is formally verified. Chapter 1 provides an introduction to the entire project, while Chapter 2 gives a brief overview of the problem domain, the nature of accidents, model based development, and the four-variable model. Chapter 3 outlines the approach. Chapter 4 presents the results of the traditional safety analysis techniques and illustrates how the hazardous conditions associated with the system trace into specific safety properties. Chapter 5 presents the results of the formal methods analysis technique model checking that was used to verify the presence of the safety properties in the requirements model. Finally, Chapter 6 summarizes the main conclusions of the study, first and foremost that model checking is a very effective verification technique to use on discrete models with reasonable state spaces. Additional supporting details are provided in the appendices.

Butler, Ricky W. (Technical Monitor); Tribble, Alan C.; Miller, Steven P.; Lempia, David L.

2004-01-01

129

Applied Simulation for Rail Crossing Economics and Safety Analysis  

E-print Network

. . . . . Applied Simulation for Rail Crossing Economics and Safety Analysis Hao Zhou Alan Zhang · Developing a simulation tool to support rail crossing analysis, including: ­ Calculate rail crossing delay ­ Analyze impact to local traffic ­ Support rail crossing economics · Applying simulation to container

Illinois at Urbana-Champaign, University of

130

A stability analysis for a semilinear parabolic partial differential equation  

NASA Technical Reports Server (NTRS)

The parabolic partial differential equation considered is u sub t = u sub xx + f(u), where minus infinity x plus infinity and o t plus infinity. Under suitable hypotheses pertaining to f, a class of initial data is exhibited: phi(x), minus infinity x plus infinity, for which the corresponding solutions u(x,t) appraoch zero as t approaches the limit of plus infinity. This convergence is uniform with respect to x on any compact subinterval of the real axis.

Chafee, N.

1973-01-01

131

Elementary-field analysis of partially coherent beam shaping.  

PubMed

We consider spatial shaping of partially coherent fields in two types of optical systems: a 2F Fourier-transforming system with the beam shaping element in the input plane and a 4F imaging system with the element in the intermediate Fourier plane. Different representations of the spatially partially coherent field in terms of fully coherent fields are examined to permit reduction of the dimensionality of the propagation integrals. The standard Mercer-type coherent-mode representation of the incident cross-spectral density (CSD) function is compared to expansions of CSD in either spatially or angularly shifted elementary field modes, all sharing the same spatial profile. In Fourier-transforming systems, the angular elementary-field representation proves computationally superior, while in imaging systems the spatially shifted elementary-field expansion is the best choice. Considering the Fourier-plane element as a generalized pupil, the latter leads to the concept's generalized amplitude associated with the elementary field and to a generalized transfer function of the system. These concepts reduce to the standard point spread function and the optical transfer function in the limit of spatial incoherence at the object plane. Examples of the effects of partial coherence in spatial beam shaping are given. PMID:24323023

Singh, Manisha; Tervo, Jani; Turunen, Jari

2013-12-01

132

RISMC ADVANCED SAFETY ANALYSIS WORKING PLAN – FY 2015 – FY 2019  

SciTech Connect

SUMMARY In this report, the Advanced Safety Analysis Program (ASAP) objectives and value proposition is described. ASAP focuses on modernization of nuclear power safety analysis (tools, methods and data); implementing state-of-the-art modeling techniques (which include, for example, enabling incorporation of more detailed physics as they become available); taking advantage of modern computing hardware; and combining probabilistic and mechanistic analyses to enable a risk informed safety analysis process. The modernized tools will maintain the current high level of safety in our nuclear power plant fleet, while providing an improved understanding of safety margins and the critical parameters that affect them. Thus, the set of tools will provide information to inform decisions on plant modifications, refurbishments, and surveillance programs, while improving economics. The set of tools will also benefit the design of new reactors, enhancing safety per unit cost of a nuclear plant. As part of the discussion, we have identified three sets of stakeholders, the nuclear industry, the Department of Energy (DOE), and associated oversight organizations. These three groups would benefit from ASAP in different ways. For example, within the DOE complex, the possible applications that are seen include the safety of experimental reactors, facility life extension, safety-by-design in future generation advanced reactors, and managing security for the storage of nuclear material. This report provides information in five areas: 1. A value proposition (“why is this important?”) that will make the case for stakeholder’s use of the ASAP research and development (R&D) products. 2. An identification of likely end users and pathway to adoption of enhanced tools by the end-users. 3. A proposed set of practical and achievable “use case” demonstrations. 4. A proposed plan to address ASAP verification and validation (V&V) needs. 5. A proposed schedule for the multi-year ASAP.

Szilard, Ronaldo H; Smith, Curtis L

2014-09-01

133

Sequential Analysis of Quality of Life Measurements with the Mixed Partial Credit  

E-print Network

1 Sequential Analysis of Quality of Life Measurements with the Mixed Partial Credit Model V and phrases: Quality of life; Item Response Theory; Partial Credit Model; Mixed models; Sequential Tests to measure Health-Related Quality of Life (QoL) which refers to "the extent to which one's usual or expected

Mesbah, Mounir

134

UNIPALS: SOFTWARE FOR PRINCIPAL COMPONENTS ANALYSIS AND PARTIAL LEAST SQUARES REGRESSION  

EPA Science Inventory

Software for the analysis of multivariate chemical data by principal components and partial least squares methods is included on disk. he methods extract latent variables from the chemical data with the UNIversal PArtial Least Squares or UNIPALS algorithm. he software is written ...

135

Content Analysis and Summarization for Video A Thesis Submitted in Partial Fulfillment  

E-print Network

Content Analysis and Summarization for Video Documents Lu, Shi A Thesis Submitted in Partial struc- ture analysis, video scene analysis, graph modeling and optimization. Both a dynamic video content coverage and the visual coherence. iii #12;iv Content Analysis and Summarization for Video

King, Kuo Chin Irwin

136

System safety analysis of an autonomous mobile robot  

SciTech Connect

Analysis of the safety of operating and maintaining the Stored Waste Autonomous Mobile Inspector (SWAMI) II in a hazardous environment at the Fernald Environmental Management Project (FEMP) was completed. The SWAMI II is a version of a commercial robot, the HelpMate{trademark} robot produced by the Transitions Research Corporation, which is being updated to incorporate the systems required for inspecting mixed toxic chemical and radioactive waste drums at the FEMP. It also has modified obstacle detection and collision avoidance subsystems. The robot will autonomously travel down the aisles in storage warehouses to record images of containers and collect other data which are transmitted to an inspector at a remote computer terminal. A previous study showed the SWAMI II has economic feasibility. The SWAMI II will more accurately locate radioactive contamination than human inspectors. This thesis includes a System Safety Hazard Analysis and a quantitative Fault Tree Analysis (FTA). The objectives of the analyses are to prevent potentially serious events and to derive a comprehensive set of safety requirements from which the safety of the SWAMI II and other autonomous mobile robots can be evaluated. The Computer-Aided Fault Tree Analysis (CAFTA{copyright}) software is utilized for the FTA. The FTA shows that more than 99% of the safety risk occurs during maintenance, and that when the derived safety requirements are implemented the rate of serious events is reduced to below one event per million operating hours. Training and procedures in SWAMI II operation and maintenance provide an added safety margin. This study will promote the safe use of the SWAMI II and other autonomous mobile robots in the emerging technology of mobile robotic inspection.

Bartos, R.J.

1994-08-01

137

Direct Calculation of the Scattering Amplitude Without Partial Wave Analysis  

NASA Technical Reports Server (NTRS)

Two new developments in scattering theory are reported. We show, in a practical way, how one can calculate the full scattering amplitude without invoking a partial wave expansion. First, the integral expression for the scattering amplitude f(theta) is simplified by an analytic integration over the azimuthal angle. Second, the full scattering wavefunction which appears in the integral expression for f(theta) is obtained by solving the Schrodinger equation with the finite element method (FEM). As an example, we calculate electron scattering from the Hartree potential. With minimal computational effort, we obtain accurate and stable results for the scattering amplitude.

Shertzer, J.; Temkin, A.; Fisher, Richard R. (Technical Monitor)

2001-01-01

138

Safety and human factors engineering analysis. Heat recovery incinerator installation  

NASA Astrophysics Data System (ADS)

This report contains a safety and human factors analysis of the Navy's heat recovery incinerator (HRI) systems. These requirements were based on current military standards and an evaluation of the HRI's at NAS, Jacksonville and NS, Mayport, Fl. The data collected were used to develop preliminary design criteria for future HRIs. The safety analysis lists specific areas where problems can occur and what should be done to prevent injury to plant personnel. The human factors design criteria section lists steps that can be taken to improve personnel and plant operating efficiency. Finally, specific problems that are occurring at NAS, Jacksonville and NS, Mayport are given.

1982-09-01

139

Multivariate analysis of remote LIBS spectra using partial least squares, principal component analysis, and related techniques  

SciTech Connect

Quantitative analysis with LIBS traditionally employs calibration curves that are complicated by the chemical matrix effects. These chemical matrix effects influence the LIBS plasma and the ratio of elemental composition to elemental emission line intensity. Consequently, LIBS calibration typically requires a priori knowledge of the unknown, in order for a series of calibration standards similar to the unknown to be employed. In this paper, three new Multivariate Analysis (MV A) techniques are employed to analyze the LIBS spectra of 18 disparate igneous and highly-metamorphosed rock samples. Partial Least Squares (PLS) analysis is used to generate a calibration model from which unknown samples can be analyzed. Principal Components Analysis (PCA) and Soft Independent Modeling of Class Analogy (SIMCA) are employed to generate a model and predict the rock type of the samples. These MV A techniques appear to exploit the matrix effects associated with the chemistries of these 18 samples.

Clegg, Samuel M [Los Alamos National Laboratory; Barefield, James E [Los Alamos National Laboratory; Wiens, Roger C [Los Alamos National Laboratory; Sklute, Elizabeth [MT HOLYOKE COLLEGE; Dyare, Melinda D [MT HOLYOKE COLLEGE

2008-01-01

140

14 CFR 33.75 - Safety analysis.  

Code of Federal Regulations, 2010 CFR

...the analysis. (ii) Consequential secondary failures and latent failures. (iii) Multiple failures referred to in paragraph...verification of the serviceability of items that could fail in a latent manner. When necessary to prevent hazardous engine...

2010-01-01

141

System Safety Analysis of Well-Control Equipment  

Microsoft Academic Search

In the wake of recent disasters in the oil and gas E and P and petrochemical industries, the importance of system safety analysis is becoming recognized. Reliability assessment techniques, which were developed in the nuclear-power-generation and defense industries, are potentially valuable tools for engineers in the offshore oil and gas business. BOP's and their control systems used on offshore rigs

J. H. Fowler; J. R. Roche

1994-01-01

142

Job Safety Analysis College/Department/Unit: Mechanical Engineering  

E-print Network

Razavi Tousi), knowledge of chemical reactions taking place before, during or after milling. Monitoring By Signature Individual worker sign off for reading and understanding the Job Safety Analysis: Date Name NSID reaction Knowledge of what is going to happen in the mill is necessary. If there is a possible reaction

Saskatchewan, University of

143

Multiple counters automata, safety analysis and Presburger arithmetic  

E-print Network

). This result can be used for the safety analysis of multiple counters automata. 1 Introduction Finite state is the relatively weak expressive­ ness of the finite state automata models. Many actual reactive systems require configuration ?'' For finite state automata, it is not difficult to compute all reachable states

Comon-Lundh, Hubert

144

Safety Analysis of Sugar Cataract Development Using Stochastic Hybrid Systems  

E-print Network

Safety Analysis of Sugar Cataract Development Using Stochastic Hybrid Systems Derek Riley continuous dynamics [6]. In this paper we model Sugar Cataract Development (SCD) as a SHS, and we present a probabilistic verification method for computing the probability of sugar cataract formation for different

Koutsoukos, Xenofon D.

145

Sensitivity analysis of the reactor safety study. Final report  

Microsoft Academic Search

The Reactor Safety Study (RSS) or Wash 1400 developed a methodology estimating the public risk from light water nuclear reactors. In order to give further insights into this study, a sensitivity analysis has been performed to determine the significant contributors to risk for both the PWR and BWR. The sensitivity to variation of the point values of the failure probabilities

W. J. Parkinson; N. C. Rasmussen; W. D. Hinkle

1979-01-01

146

Probabilistic safety analysis. Final report. [PWR and BWR  

Microsoft Academic Search

This is the final report on project RP271-2. It discusses the development of a functioning, dedicated, research group in the area of probabilistic analysis and it describes the early efforts in applying the methodologies. Work has centered on mining the Reactor Safety Study (WASH-1400), developing new computer code capabilities, and work has started on a reappraisal of the ATWS problem.

Erdmann

1977-01-01

147

Safety analysis of SISL process module  

SciTech Connect

This report provides an assessment of various postulated accidental occurrences within an experimental process module which is part of a Special Isotope Separation Laboratory (SISL) currently under construction at the Lawrence Livermore National Laboratory (LLNL). The process module will contain large amounts of molten uranium and various water-cooled structures within a vacuum vessel. Special emphasis is therefore given to potential accidental interactions of molten uranium with water leading to explosive and/or rapid steam formation, as well as uranium oxidation and the potential for combustion. Considerations are also given to the potential for vessel melt-through. Evaluations include mechanical and thermal interactions and design implications both in terms of design basis as well as once-in-a-lifetime accident scenarios. These scenarios include both single- and multiple-failure modes leading to various contact modes and locations within the process module for possible thermal interactions. The evaluations show that a vacuum vessel design based upon nominal operating conditions would appear sufficient to meet safety requirements in connection with both design basis as well as once-in-a-lifetime accidents. Controlled venting requirements for removal of steam and hydrogen in order to avoid possible long-term pressurization events are recommended. Depending upon the resulting accident conditions, the vacuum system (i.e., the roughing system) could also serve this purpose. Finally, based upon accident evaluations of this study, immediate shut-off of all coolant water following an incident leak is not recommended, as such action may have adverse effects in terms of cool-down requirements for the melt crucibles etc. These requirements have not been assessed as part of this study.

Not Available

1983-05-01

148

Analysis of the Safety Properties of a System from the Viewpoint of the  

E-print Network

deals with the safety procedures associated with the launching and flight of a sounding rocket. Keywords: safety-critical systems, safety analysis, objects, collaborations, formal models, sounding rockets 1Analysis of the Safety Properties of a System from the Viewpoint of the Interactions of its

Newcastle upon Tyne, University of

149

Transperitoneal Approach versus Retroperitoneal Approach: A Meta-Analysis of Laparoscopic Partial Nephrectomy for Renal Cell Carcinoma  

PubMed Central

Objective To compare the efficiency and safety of the transperitoneal approaches with retroperitoneal approaches in laparoscopic partial nephrectomy for renal cell carcinoma and provide evidence-based medicine support for clinical treatment. Methods A systematic computer search of PUBMED, EMBASE, and the Cochrane Library was executed to identify retrospective observational and prospective randomized controlled trials studies that compared the outcomes of the two approaches in laparoscopic partial nephrectomy. Two reviewers independently screened, extracted, and evaluated the included studies and executed statistical analysis by using software STATA 12.0. Outcomes of interest included perioperative and postoperative variables, surgical complications and oncological variables. Results There were 8 studies assessed transperitoneal laparoscopic partial nephrectomy (TLPN) versus retroperitoneal laparoscopic partial nephrectomy (RLPN) were included. RLPN had a shorter operating time (SMD?=?1.001,95%confidence interval[CI] 0.609–1.393,P<0.001), a lower estimated blood loss (SMD?=?0.403,95%CI 0.015–0.791,P?=?0.042) and a shorter length of hospital stay (WMD?=?0.936 DAYS,95%CI 0.609–1.263,P<0.001) than TLPN. There were no significant differences between the transperitoneal and retroperitoneal approaches in other outcomes of interest. Conclusions This meta-analysis indicates that, in appropriately selected patients, especially patients with intraperitoneal procedures history or posteriorly located renal tumors, the RLPN can shorten the operation time, reduce the estimated blood loss and shorten the length of hospital stay. RLPN may be equally safe and be faster compared with the TLPN. PMID:24658032

Zhao, Xiaowen; Ni, Shaobin; Zhang, Cheng; Guo, Changgang; Ren, Minghua

2014-01-01

150

Environmental and safety envelope analysis for inertial fusion applications  

SciTech Connect

This paper describes an envelope analysis concept and a generic process flow model which together can be used to identify and isolate plant functions and provide for detailed mass- and energy-balance bookkeeping for environmental and safety studies. Los Alamos Scientific Laboratory's (LASL) two laser fusion power plant concepts were analyzed with this approach. Samples of the detailed tables of material flow rates into and out of an envelope are presented in this paper. The tritium and lithium inventories and air activation were identified as having important potential environmental problems and safety risks.

Freiwald, J.G.; Pendergrass, J.H.; Frank, T.G.

1980-01-01

151

Fuel Storage Facility Final Safety Analysis Report. Revision 1  

SciTech Connect

The Fuel Storage Facility (FSF) is an integral part of the Fast Flux Test Facility. Its purpose is to provide long-term storage (20-year design life) for spent fuel core elements used to provide the fast flux environment in FFTF, and for test fuel pins, components and subassemblies that have been irradiated in the fast flux environment. This Final Safety Analysis Report (FSAR) and its supporting documentation provides a complete description and safety evaluation of the site, the plant design, operations, and potential accidents.

Linderoth, C.E.

1984-03-01

152

Safety analysis report for packaging (onsite) multicanister overpack cask  

SciTech Connect

This safety analysis report for packaging (SARP) documents the safety of shipments of irradiated fuel elements in the MUlticanister Overpack (MCO) and MCO Cask for a highway route controlled quantity, Type B fissile package. This SARP evaluates the package during transfers of (1) water-filled MCOs from the K Basins to the Cold Vacuum Drying Facility (CVDF) and (2) sealed and cold vacuum dried MCOs from the CVDF in the 100 K Area to the Canister Storage Building in the 200 East Area.

Edwards, W.S.

1997-07-14

153

Style, content and format guide for writing safety analysis documents. Volume 1, Safety analysis reports for DOE nuclear facilities  

SciTech Connect

The purpose of Volume 1 of this 4-volume style guide is to furnish guidelines on writing and publishing Safety Analysis Reports (SARs) for DOE nuclear facilities at Sandia National Laboratories. The scope of Volume 1 encompasses not only the general guidelines for writing and publishing, but also the prescribed topics/appendices contents along with examples from typical SARs for DOE nuclear facilities.

Not Available

1994-06-01

154

Worker Safety and Health and Nuclear Safety Quarterly Performance Analysis (January - March 2008)  

SciTech Connect

The DOE Office of Enforcement expects LLNL to 'implement comprehensive management and independent assessments that are effective in identifying deficiencies and broader problems in safety and security programs, as well as opportunities for continuous improvement within the organization' and to 'regularly perform assessments to evaluate implementation of the contractor's processes for screening and internal reporting.' LLNL has a self-assessment program, described in ES&H Manual Document 4.1, that includes line, management and independent assessments. LLNL also has in place a process to identify and report deficiencies of nuclear, worker safety and health and security requirements. In addition, the DOE Office of Enforcement expects LLNL to evaluate 'issues management databases to identify adverse trends, dominant problem areas, and potential repetitive events or conditions' (page 14, DOE Enforcement Process Overview, December 2007). LLNL requires that all worker safety and health and nuclear safety noncompliances be tracked as 'deficiencies' in the LLNL Issues Tracking System (ITS). Data from the ITS are analyzed for worker safety and health (WSH) and nuclear safety noncompliances that may meet the threshold for reporting to the DOE Noncompliance Tracking System (NTS). This report meets the expectations defined by the DOE Office of Enforcement to review the assessments conducted by LLNL, analyze the issues and noncompliances found in these assessments, and evaluate the data in the ITS database to identify adverse trends, dominant problem areas, and potential repetitive events or conditions. The report attempts to answer three questions: (1) Is LLNL evaluating its programs and state of compliance? (2) What is LLNL finding? (3) Is LLNL appropriately managing what it finds? The analysis in this report focuses on data from the first quarter of 2008 (January through March). This quarter is analyzed within the context of information identified in previous quarters to include April 2007 through March 2008. The results from analyzing the deficiencies are presented in accordance with the two primary NTS reporting thresholds for WSH and nuclear safety noncompliances: (1) those related to certain events or conditions and (2) those that are management issues. In addition, WSH noncompliances were also analyzed to determine if any fell under the 'other significant condition' threshold. This report also identifies noncompliance topical areas that may have issues that do not meet the NTS reporting threshold but should remain under observation. These are placed on the 'watch list' for continued analysis.

Kerr, C E

2009-10-07

155

Computational Methods for Sensitivity and Uncertainty Analysis in Criticality Safety  

SciTech Connect

Interest in the sensitivity methods that were developed and widely used in the 1970s (the FORSS methodology at ORNL among others) has increased recently as a result of potential use in the area of criticality safety data validation procedures to define computational bias, uncertainties and area(s) of applicability. Functional forms of the resulting sensitivity coefficients can be used as formal parameters in the determination of applicability of benchmark experiments to their corresponding industrial application areas. In order for these techniques to be generally useful to the criticality safety practitioner, the procedures governing their use had to be updated and simplified. This paper will describe the resulting sensitivity analysis tools that have been generated for potential use by the criticality safety community.

Broadhead, B.L.; Childs, R.L.; Rearden, B.T.

1999-09-20

156

General aviation air traffic pattern safety analysis  

NASA Technical Reports Server (NTRS)

A concept is described for evaluating the general aviation mid-air collision hazard in uncontrolled terminal airspace. Three-dimensional traffic pattern measurements were conducted at uncontrolled and controlled airports. Computer programs for data reduction, storage retrieval and statistical analysis have been developed. Initial general aviation air traffic pattern characteristics are presented. These preliminary results indicate that patterns are highly divergent from the expected standard pattern, and that pattern procedures observed can affect the ability of pilots to see and avoid each other.

Parker, L. C.

1973-01-01

157

Three-dimensional analysis of partially open butterfly valve flows  

SciTech Connect

A numerical simulation of butterfly valve flows is a useful technique to investigate the physical phenomena of the flow field. A three-dimensional numerical analysis was carried out on incompressible fluid flows in a butterfly valve by using FLUENT, which solves difference equations. Characteristics of the butterfly valve flows at different valve disk angles with a uniform incoming velocity were investigated. Comparisons of FLUENT results with other results, i.e., experimental results, were made to determine the accuracy of the employed method. Results of the three-dimensional analysis may be useful in the valve design.

Huang, C.; Kim, R.H. [Univ. of North Carolina, Charlotte, NC (United States). Dept. of Mechanical Engineering and Engineering Science

1996-09-01

158

Ares I-X Range Safety Flight Envelope Analysis  

NASA Technical Reports Server (NTRS)

Ares I-X was the first test flight of NASA's Constellation Program's Ares I Crew Launch Vehicle designed to provide manned access to low Earth orbit. As a one-time test flight, the Air Force's 45th Space Wing required a series of Range Safety analysis data products to be developed for the specified launch date and mission trajectory prior to granting flight approval on the Eastern Range. The range safety data package is required to ensure that the public, launch area, and launch complex personnel and resources are provided with an acceptable level of safety and that all aspects of prelaunch and launch operations adhere to applicable public laws. The analysis data products, defined in the Air Force Space Command Manual 91-710, Volume 2, consisted of a nominal trajectory, three sigma trajectory envelopes, stage impact footprints, acoustic intensity contours, trajectory turn angles resulting from potential vehicle malfunctions (including flight software failures), characterization of potential debris, and debris impact footprints. These data products were developed under the auspices of the Constellation's Program Launch Constellation Range Safety Panel and its Range Safety Trajectory Working Group with the intent of beginning the framework for the operational vehicle data products and providing programmatic review and oversight. A multi-center NASA team in conjunction with the 45th Space Wing, collaborated within the Trajectory Working Group forum to define the data product development processes, performed the analyses necessary to generate the data products, and performed independent verification and validation of the data products. This paper outlines the Range Safety data requirements and provides an overview of the processes established to develop both the data products and the individual analyses used to develop the data products, and it summarizes the results of the analyses required for the Ares I-X launch.

Starr, Brett R.; Olds, Aaron D.; Craig, Anthony S.

2011-01-01

159

Partial Derivative Games in Thermodynamics: A Cognitive Task Analysis  

ERIC Educational Resources Information Center

Several studies in recent years have demonstrated that upper-division students struggle with the mathematics of thermodynamics. This paper presents a task analysis based on several expert attempts to solve a challenging mathematics problem in thermodynamics. The purpose of this paper is twofold. First, we highlight the importance of cognitive task…

Kustusch, Mary Bridget; Roundy, David; Dray, Tevian; Manogue, Corinne A.

2014-01-01

160

An antiproton-proton partial-wave analysis  

SciTech Connect

Partial-wave analyses (PWAs) have a long history in the fields of {pi}N and NN scattering. Due to the poor quality of low-energy antiproton beams and the resulting absence of accurate experimental data, analogous model-independent studies of the much more complex {bar p}p system have in the past always been impossible. In the pre-LEAR era spin-dependent observables and charge-exchange ({bar p}p - {bar n}n) data were almost nonexistent, the situation between 400 and 925 MeV/c is now quite good. High-quality analyzing-power data have been obtained for the elastic and charge-exchange reactions. Very recently, even charge-exchange depolarization data have become available. Unfortunately, the practical difficulties involved in constructing a high-quality ``cooled`` antiproton beam of lower momentum are large. Consequently, the {bar p}p database below about 400 MeV/c is still by far not as good as one would like, in striking contrast to the pp case where very accurate data exist as low as T{sub L} = 0.35 MeV. It also remains an outstanding experimental challenge to construct a polarized antiproton beam to further probe the spin structure of the interaction. A new method has been developed by the Nijmegen group to perform PWAs of the abundant and accurate NN scattering data below T{sub L} = 350 MeV. With the now available high-quality data from LEAR and KEK, we have been able to extend the methods used in these NN PWAs to perform an energy-dependent PWA of all {bar p}p scattering data below p{sub L} = 925 MeV/c. The same methods of PWA have also been applied to the strangeness-exchange reaction {bar p}p {yields} {bar {lambda}}{lambda}, for which the PS185 group at LEAR has obtained beautiful data. In the next section we review the theoretical ideas behind these Nijmegen PWAS, and we apply these ideas and methods to the case of {bar p}p scattering. In section IV some results of this {bar p}p PWA are presented and discussed.

Timmermans, R. [Los Alamos National Lab., NM (United States); Rijken, T.A.; de Swart, J.J. [Katholieke Univ. Nijmegen (Netherlands). Inst. for Theoretical Physics

1993-11-01

161

78 FR 4477 - Review of Safety Analysis Reports for Nuclear Power Plants, Introduction  

Federal Register 2010, 2011, 2012, 2013, 2014

...Safety Analysis Reports for Nuclear Power Plants: Integral Pressurized Water Reactor...Safety Analysis Reports for Nuclear Power Plants: Integral Pressurized Water...This subsection has been developed to assist NRC staff with the...

2013-01-22

162

Analysis of Factors Affecting Containment with Extracted Partial Enclosures Using Computational Fluid Dynamics  

PubMed Central

The Health and Safety Executive’s (HSE’s) COSHH Essentials (HSE, 2002, COSHH Essentials: easy steps to control chemicals HSG193. 2nd edn. ISBN 0 71762737 3. Available at http://www.coshh-essentials.org.uk. Accessed 30 October 2013) provides guidance on identifying the approaches required to control exposure to chemicals in the workplace. The control strategies proposed in COSHH Essentials are grouped into four control approaches: general ventilation, engineering control, containment, or to seek specialist advice. We report the use of experimental measurements and computational fluid dynamics (CFD) modelling to examine the performance of an engineering control approach and a containment control approach. The engineering control approach simulated was an extracted partial enclosure, based on the COSHH Essentials G200, for which simulations were compared with data from experiments. The containment approach simulated was of drum filling (in an extracted partial enclosure), based on the COSHH Essentials G305. The influence of the following factors on containment was examined: face velocity, size and location of face opening, and movement and ventilation flows. CFD predictions of the engineering control approach agreed well with the majority of the experimental measurements demonstrating confidence in the modelling approach used. The results show that the velocity distribution at the face of the enclosure is not uniform and the location and size of the opening are significant factors affecting the flow field and hence the containment performance. The simulations of drum filling show the effect on containment of the movement of a drum through the face of an enclosure. Analysis of containment performance, using a tracer, showed that containment was affected by the interaction between the ventilation flow direction and drum movement and spacing. Validated CFD simulations are shown to be a useful tool for gaining insight into the flows in control strategies for exposure control and to aid the interpretation of experimental measurements. The results support the assumption in COSHH Essentials that the use of ‘containment’ as a control approach is capable of achieving a 100-fold reduction in potential exposure. Novel CFD modelling techniques have been used to create controlled containment scenarios, improve understanding of the flow behaviour in the scenarios, and provide information that may aid future containment design. PMID:24232543

Batt, Rachel L.; Kelsey, Adrian

2014-01-01

163

Analysis of factors affecting containment with extracted partial enclosures using computational fluid dynamics.  

PubMed

The Health and Safety Executive's (HSE's) COSHH Essentials (HSE, 2002, COSHH Essentials: easy steps to control chemicals HSG193. 2nd edn. ISBN 0 71762737 3. Available at http://www.coshh-essentials.org.uk. Accessed 30 October 2013) provides guidance on identifying the approaches required to control exposure to chemicals in the workplace. The control strategies proposed in COSHH Essentials are grouped into four control approaches: general ventilation, engineering control, containment, or to seek specialist advice. We report the use of experimental measurements and computational fluid dynamics (CFD) modelling to examine the performance of an engineering control approach and a containment control approach. The engineering control approach simulated was an extracted partial enclosure, based on the COSHH Essentials G200, for which simulations were compared with data from experiments. The containment approach simulated was of drum filling (in an extracted partial enclosure), based on the COSHH Essentials G305. The influence of the following factors on containment was examined: face velocity, size and location of face opening, and movement and ventilation flows. CFD predictions of the engineering control approach agreed well with the majority of the experimental measurements demonstrating confidence in the modelling approach used. The results show that the velocity distribution at the face of the enclosure is not uniform and the location and size of the opening are significant factors affecting the flow field and hence the containment performance. The simulations of drum filling show the effect on containment of the movement of a drum through the face of an enclosure. Analysis of containment performance, using a tracer, showed that containment was affected by the interaction between the ventilation flow direction and drum movement and spacing. Validated CFD simulations are shown to be a useful tool for gaining insight into the flows in control strategies for exposure control and to aid the interpretation of experimental measurements. The results support the assumption in COSHH Essentials that the use of 'containment' as a control approach is capable of achieving a 100-fold reduction in potential exposure. Novel CFD modelling techniques have been used to create controlled containment scenarios, improve understanding of the flow behaviour in the scenarios, and provide information that may aid future containment design. PMID:24232543

Batt, Rachel L; Kelsey, Adrian

2014-03-01

164

Analysis of Cardio-respiratory Dynamics during Mental Stress using (Partial) Time-Frequency Spectra  

E-print Network

to conduct a combined analysis of the cardio-respiratory system. In this study, we will perform cross timeAnalysis of Cardio-respiratory Dynamics during Mental Stress using (Partial) Time-Frequency Spectra Engineering, ESAT - STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven

165

Evaluation of safety assessment methodologies in Rocky Flats Risk Assessment Guide (1985) and Building 707 Final Safety Analysis Report (1987)  

SciTech Connect

FSARs. Rockwell International, as operating contractor at the Rocky Flats plant, conducted a safety analysis program during the 1980s. That effort resulted in Final Safety Analysis Reports (FSARs) for several buildings, one of them being the Building 707 Final Safety Analysis Report, June 87 (707FSAR) and a Plant Safety Analysis Report. Rocky Flats Risk Assessment Guide, March 1985 (RFRAG85) documents the methodologies that were used for those FSARs. Resources available for preparation of those Rocky Flats FSARs were very limited. After addressing the more pressing safety issues, some of which are described below, the present contractor (EG&G) intends to conduct a program of upgrading the FSARs. This report presents the results of a review of the methodologies described in RFRAG85 and 707FSAR and contains suggestions that might be incorporated into the methodology for the FSAR upgrade effort.

Walsh, B.; Fisher, C.; Zigler, G.; Clark, R.A. [Science and Engineering Associates, Inc., Albuquerque, NM (United States)

1990-11-09

166

PAT-1 safety analysis report addendum.  

SciTech Connect

The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The purpose of this SAR Addendum is to incorporate plutonium (Pu) metal as a new payload for the PAT-1 package. The Pu metal is packed in an inner container (designated the T-Ampoule) that replaces the PC-1 inner container. The documentation and results from analysis contained in this addendum demonstrate that the replacement of the PC-1 and associated packaging material with the T-Ampoule and associated packaging with the addition of the plutonium metal content are not significant with respect to the design, operating characteristics, or safe performance of the containment system and prevention of criticality when the package is subjected to the tests specified in 10 CFR 71.71, 71.73 and 71.74.

Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

2010-09-01

167

14 CFR Appendix J to Part 417 - Ground Safety Analysis Report  

Code of Federal Regulations, 2010 CFR

...subsystems. A ground safety analysis report must describe...subsystem, the ground safety analysis report must provide a...component level such as tanks, engines and vents...subsystems. A ground safety analysis report must identify...the control, such as design margin, fault...

2010-01-01

168

Safety Analysis of Software Product Lines Using State-Based Modeling  

Microsoft Academic Search

The analysis and management of variations (such as optional features) are central to the development of safety-critical, software product lines. However, the difficulty of managing variations, and the potential interactions among them, across an entire product line currently hinders safety analysis in such systems. The work described here contributes to a solution by integrating safety analysis of a product line

Jing Liu; Josh Dehlinger; Robyn R. Lutz

2005-01-01

169

Multivariate qualitative analysis of banned additives in food safety using surface enhanced Raman scattering spectroscopy  

NASA Astrophysics Data System (ADS)

A novel strategy which combines iteratively cubic spline fitting baseline correction method with discriminant partial least squares qualitative analysis is employed to analyze the surface enhanced Raman scattering (SERS) spectroscopy of banned food additives, such as Sudan I dye and Rhodamine B in food, Malachite green residues in aquaculture fish. Multivariate qualitative analysis methods, using the combination of spectra preprocessing iteratively cubic spline fitting (ICSF) baseline correction with principal component analysis (PCA) and discriminant partial least squares (DPLS) classification respectively, are applied to investigate the effectiveness of SERS spectroscopy for predicting the class assignments of unknown banned food additives. PCA cannot be used to predict the class assignments of unknown samples. However, the DPLS classification can discriminate the class assignment of unknown banned additives using the information of differences in relative intensities. The results demonstrate that SERS spectroscopy combined with ICSF baseline correction method and exploratory analysis methodology DPLS classification can be potentially used for distinguishing the banned food additives in field of food safety.

He, Shixuan; Xie, Wanyi; Zhang, Wei; Zhang, Liqun; Wang, Yunxia; Liu, Xiaoling; Liu, Yulong; Du, Chunlei

2015-02-01

170

Multivariate qualitative analysis of banned additives in food safety using surface enhanced Raman scattering spectroscopy.  

PubMed

A novel strategy which combines iteratively cubic spline fitting baseline correction method with discriminant partial least squares qualitative analysis is employed to analyze the surface enhanced Raman scattering (SERS) spectroscopy of banned food additives, such as Sudan I dye and Rhodamine B in food, Malachite green residues in aquaculture fish. Multivariate qualitative analysis methods, using the combination of spectra preprocessing iteratively cubic spline fitting (ICSF) baseline correction with principal component analysis (PCA) and discriminant partial least squares (DPLS) classification respectively, are applied to investigate the effectiveness of SERS spectroscopy for predicting the class assignments of unknown banned food additives. PCA cannot be used to predict the class assignments of unknown samples. However, the DPLS classification can discriminate the class assignment of unknown banned additives using the information of differences in relative intensities. The results demonstrate that SERS spectroscopy combined with ICSF baseline correction method and exploratory analysis methodology DPLS classification can be potentially used for distinguishing the banned food additives in field of food safety. PMID:25300041

He, Shixuan; Xie, Wanyi; Zhang, Wei; Zhang, Liqun; Wang, Yunxia; Liu, Xiaoling; Liu, Yulong; Du, Chunlei

2015-02-25

171

Safety analysis report for packaging (onsite) sample pig transport system  

SciTech Connect

This Safety Analysis Report for Packaging (SARP) provides a technical evaluation of the Sample Pig Transport System as compared to the requirements of the U.S. Department of Energy, Richland Operations Office (RL) Order 5480.1, Change 1, Chapter III. The evaluation concludes that the package is acceptable for the onsite transport of Type B, fissile excepted radioactive materials when used in accordance with this document.

MCCOY, J.C.

1999-03-16

172

Safety analysis, risk assessment, and risk acceptance criteria  

SciTech Connect

This paper discusses a number of topics that relate safety analysis as documented in the Department of Energy (DOE) safety analysis reports (SARs), probabilistic risk assessments (PRA) as characterized primarily in the context of the techniques that have assumed some level of formality in commercial nuclear power plant applications, and risk acceptance criteria as an outgrowth of PRA applications. DOE SARs of interest are those that are prepared for DOE facilities under DOE Order 5480.23 and the implementing guidance in DOE STD-3009-94. It must be noted that the primary area of application for DOE STD-3009 is existing DOE facilities and that certain modifications of the STD-3009 approach are necessary in SARs for new facilities. Moreover, it is the hazard analysis (HA) and accident analysis (AA) portions of these SARs that are relevant to the present discussions. Although PRAs can be qualitative in nature, PRA as used in this paper refers more generally to all quantitative risk assessments and their underlying methods. HA as used in this paper refers more generally to all qualitative risk assessments and their underlying methods that have been in use in hazardous facilities other than nuclear power plants. This discussion includes both quantitative and qualitative risk assessment methods. PRA has been used, improved, developed, and refined since the Reactor Safety Study (WASH-1400) was published in 1975 by the Nuclear Regulatory Commission (NRC). Much debate has ensued since WASH-1400 on exactly what the role of PRA should be in plant design, reactor licensing, `ensuring` plant and process safety, and a large number of other decisions that must be made for potentially hazardous activities. Of particular interest in this area is whether the risks quantified using PRA should be compared with numerical risk acceptance criteria (RACs) to determine whether a facility is `safe.` Use of RACs requires quantitative estimates of consequence frequency and magnitude.

Jamali, K. [Dept. of Energy, Germantown, MD (United States). Core Technical Support and Facility Transition; Stack, D.W.; Sullivan, L.H.; Sanzo, D.L. [Los Alamos National Lab., NM (United States)

1997-08-01

173

Thermohydraulic and Safety Analysis for CARR Under Station Blackout Accident  

SciTech Connect

A thermohydraulic and safety analysis code (TSACC) has been developed using Fortran 90 language to evaluate the transient thermohydraulic behaviors and safety characteristics of the China Advanced Research Reactor(CARR) under Station Blackout Accident(SBA). For the development of TSACC, a series of corresponding mathematical and physical models were considered. Point reactor neutron kinetics model was adopted for solving reactor power. All possible flow and heat transfer conditions under station blackout accident were considered and the optional models were supplied. The usual Finite Difference Method (FDM) was abandoned and a new model was adopted to evaluate the temperature field of core plate type fuel element. A new simple and convenient equation was proposed for the resolution of the transient behaviors of the main pump instead of the complicated four-quadrant model. Gear method and Adams method were adopted alternately for a better solution to the stiff differential equations describing the dynamic behaviors of the CARR. The computational result of TSACC showed the enough safety margin of CARR under SBA. For the purpose of Verification and Validation (V and V), the simulated results of TSACC were compared with those of Relap5/Mdo3. The V and V result indicated a good agreement between the results by the two codes. Because of the adoption of modular programming techniques, this analysis code is expected to be applied to other reactors by easily modifying the corresponding function modules. (authors)

Wenxi Tian; Suizheng Qiu; Guanghui Su; Dounan Jia [Xi'an Jiaotong University, 28 Xianning Road, Xi'an 710049 (China); Xingmin Liu - China Institute of Atomic Energy

2006-07-01

174

Safety analysis, 200 Area, Savannah River Plant: Separations area operations  

SciTech Connect

The nev HB-Line, located on the fifth and sixth levels of Building 221-H, is designed to replace the aging existing HB-Line production facility. The nev HB-Line consists of three separate facilities: the Scrap Recovery Facility, the Neptunium Oxide Facility, and the Plutonium Oxide Facility. There are three separate safety analyses for the nev HB-Line, one for each of the three facilities. These are issued as supplements to the 200-Area Safety Analysis (DPSTSA-200-10). These supplements are numbered as Sup 2A, Scrap Recovery Facility, Sup 2B, Neptunium Oxide Facility, Sup 2C, Plutonium Oxide Facility. The subject of this safety analysis, the, Plutonium Oxide Facility, will convert nitrate solutions of {sup 238}Pu to plutonium oxide (PuO{sub 2}) powder. All these new facilities incorporate improvements in: (1) engineered barriers to contain contamination, (2) barriers to minimize personnel exposure to airborne contamination, (3) shielding and remote operations to decrease radiation exposure, and (4) equipment and ventilation design to provide flexibility and improved process performance.

Perkins, W.C.; Lee, R.; Allen, P.M.; Gouge, A.P.

1991-07-01

175

Risk assessment and its application to flight safety analysis  

SciTech Connect

Potentially hazardous test activities have historically been a part of Sandia National Labs mission to design, develop, and test new weapons systems. These test activities include high speed air drops for parachute development, sled tests for component and system level studies, multiple stage rocket experiments, and artillery firings of various projectiles. Due to the nature of Sandia's test programs, the risk associated with these activities can never be totally eliminated. However, a consistent set of policies should be available to provide guidance into the level of risk that is acceptable in these areas. This report presents a general set of guidelines for addressing safety issues related to rocket flight operations at Sandia National Laboratories. Even though the majority of this report deals primarily with rocket flight safety, these same principles could be applied to other hazardous test activities. The basic concepts of risk analysis have a wide range of applications into many of Sandia's current operations. 14 refs., 1 tab.

Keese, D.L.; Barton, W.R.

1989-12-01

176

Sensitivity analysis of data-related factors controlling AVA simultaneous inversion of partially stacked seismic amplitude data: Application  

E-print Network

Sensitivity analysis of data-related factors controlling AVA simultaneous inversion of partially distributions of elastic parameters is improved substantially by 1 increasing the preserved AVA in- formation

Torres-Verdín, Carlos

177

Analysis and suppression of interference for on-line monitoring of partial discharge of power transformers  

Microsoft Academic Search

The key to on-line partial discharge (PD) monitoring of power transformers is how to suppress interference effectively. This paper reports an interference qualitative and quantitative analysis on site using a Fast Fourier Transform (FFT) technique. Various periodic interferences have been found, which emanated from the carrier communication, thyristor switching, and high frequency protection signals of the power system as well

Changchang Wang; Xianlie Jin; T. C. Cheng; Shibo Zhang; Zuzhu Dong; Zhongdong Wang; Du Lin; Deheng Zhu

1997-01-01

178

Protein Folding Trajectories Analysis: Summarization, Event Detection and Consensus Partial Folding Pathway  

E-print Network

Protein Folding Trajectories Analysis: Summarization, Event Detection and Consensus Partial Folding in protein folding trajectories. We pro- pose an approach that employs the simplicity of contact maps and po- tentially cure diseases caused by misfolding. The protein folding problem is therefore one

Yang, Hui

179

Investigating Importance Weighting of Satisfaction Scores from a Formative Model with Partial Least Squares Analysis  

ERIC Educational Resources Information Center

This study introduced a formative model to investigate the utility of importance weighting on satisfaction scores with partial least squares analysis. Based on the bottom-up theory of satisfaction evaluations, the measurement structure for weighted/unweighted domain satisfaction scores was modeled as a formative model, whereas the measurement…

Wu, Chia-Huei; Chen, Lung Hung; Tsai, Ying-Mei

2009-01-01

180

Analysis of a local transient control action by partial energy functions  

Microsoft Academic Search

A partial energy function is used to quantify the energy of a local transient control action. The function is used to analyze the energy transactions of a single generator in a multimachine power system. This is in contrast with a global energy analysis of the system. Special attention is drawn to an explanation of damping as being caused by tuned

S. E. Stanton; W. P. Dykas

1989-01-01

181

Analysis of a Local Transient Control Action by Partial Energy Functions  

Microsoft Academic Search

In this paper, a partial energy function is used to quantify the energy of a local transient control action. The function is used to analyze the energy transactions of a single generator in a multimachine system. This is in contrast with a global energy analysis of the system. Dynamic braking is considered.

S. E. Stanton; W. P. Dykas

1989-01-01

182

Indirect Control Path Analysis and Goal Coverage Strategies for Elaborating System Safety Goals in Composite Systems  

E-print Network

Indirect Control Path Analysis and Goal Coverage Strategies for Elaborating System Safety Goals safety goals across a composite system. First, Indirect Control Path Analysis (ICPA) is used to identify- plicability in real safety critical embedded systems with two case studies: a distributed elevator

Koopman, Philip

183

Mathematical basis for analysis of partially coherent wave propagation in nonlinear, non-instantaneous, Kerr media  

NASA Astrophysics Data System (ADS)

A general mathematical basis for analyzing propagation of partially coherent light in nonlinear, non-instantaneous, Kerr media is presented. The presentation unifies existing approaches, but also provides the generalizations necessary for an analysis of more complicated wave fields than those previously considered. In particular, it is demonstrated how to generalize the analysis to situations where the light field originates from several sources, which do not necessarily have the same stochastic properties.

Semenov, V.; Lisak, M.; Anderson, D.; Hansson, T.; Helczynski-Wolf, L.; Österberg, U.

2008-08-01

184

Mixed Waste Management Facility Preliminary Safety Analysis Report. Chapters 1 to 20  

SciTech Connect

This document provides information on waste management practices, occupational safety, and a site characterization of the Lawrence Livermore National Laboratory. A facility description, safety engineering analysis, mixed waste processing techniques, and auxiliary support systems are included.

Not Available

1994-09-01

185

Lacosamide adjunctive therapy for partial-onset seizures: a meta-analysis  

PubMed Central

Background. The relative efficacy and safety of lacosamide as adjunctive therapy compared to other antiepileptic drugs has not been well established. Objective. To determine if lacosamide provides improved efficacy and safety, reduced length of hospital stay and improved quality of life compared with other anti-epileptic therapies for adults with partial-onset seizures. Data Sources. A systematic review of the medical literature using Medline (1946–Week 4, 2012), EMBASE (1980–Week 3, 2012), Cochrane Central Register of Controlled Trials (Issue 1 of 12, January 2012). Additional studies were identified (through to February 7, 2012) by searching bibliographies, the FDA drug approval files, clinical trial registries and major national and international neurology meeting abstracts. No restrictions on publication status or language were applied. Study Selection. Randomized controlled trials of lacosamide in adults with partial-onset seizures were included. Data Extraction. Study selection, extraction and risk of bias assessment were performed independently by two authors. Authors of studies were contacted for missing data. Data Synthesis. All pooled analyses used the random effects model. Results. Three trials (1311 patients) met inclusion criteria. Lacosamide increased the 50% responder rate compared to placebo (RR 1.68 [95% CI 1.36 to 2.08]; I2 = 0%). Discontinuation due to adverse events was statistically significantly higher in the lacosamide arm (RR3.13 [95% CI 1.94 to 5.06]; I2 = 0%). Individual adverse events (ataxia, dizziness, fatigue, and nausea) were also significantly higher in the lacosamide group. Limitations. All dosage arms from the included studies were pooled to make a single pair-wise comparison to placebo. Selective reporting of outcomes was found in all of the included RCTs. Conclusions. Lacosamide as adjunctive therapy in patients with partial-onset seizures increases the 50% responder rate but with significantly more adverse events compared to the placebo. PMID:23940830

Newman, Jennifer J.; Deshpande, Santosh; Jones, Philip M.

2013-01-01

186

Safety.  

ERIC Educational Resources Information Center

Discusses safety issues in science, including: allergic reactions to peanuts used in experiments; explosions in lead/acid batteries; and inspection of pressure vessels, such as pressure cookers or model steam engines. (MKR)

Education in Science, 1996

1996-01-01

187

Safety Analysis of Soybean Processing for Advanced Life Support  

NASA Technical Reports Server (NTRS)

Soybeans (cv. Hoyt) is one of the crops planned for food production within the Advanced Life Support System Integration Testbed (ALSSIT), a proposed habitat simulation for long duration lunar/Mars missions. Soybeans may be processed into a variety of food products, including soymilk, tofu, and tempeh. Due to the closed environmental system and importance of crew health maintenance, food safety is a primary concern on long duration space missions. Identification of the food safety hazards and critical control points associated with the closed ALSSIT system is essential for the development of safe food processing techniques and equipment. A Hazard Analysis Critical Control Point (HACCP) model was developed to reflect proposed production and processing protocols for ALSSIT soybeans. Soybean processing was placed in the type III risk category. During the processing of ALSSIT-grown soybeans, critical control points were identified to control microbiological hazards, particularly mycotoxins, and chemical hazards from antinutrients. Critical limits were suggested at each CCP. Food safety recommendations regarding the hazards and risks associated with growing, harvesting, and processing soybeans; biomass management; and use of multifunctional equipment were made in consideration of the limitations and restraints of the closed ALSSIT.

Hentges, Dawn L.

1999-01-01

188

Safety analysis of contained low-hazard biotechnology applications.  

PubMed

A technical safety analysis has been performed on a containment-level-2 pilot plant in order to assess an upgrading of the existing facility, which should comply with good manufacturing practices. The results were obtained by employing the hazard and operability (HAZOP) assessment method and are discussed in the light of the appropriateness of this procedural tool for low-hazard biotechnology applications. The potential release of micro-organisms accounts only for a minor part of the hazardous consequences. However, in certain cases the release of a large or moderate amount of micro-organisms would not be immediately identified. Most of the actions required to avoid these consequences fall into the realm of operational procedures. As a major part of potential failures result from human errors, standard operating procedures play a prominent role when establishing the concept of safety management. The HAZOP assessment method was found to be adequate for the type of process under investigation. The results also may be used for the generation of checklists which, in most cases, are sufficient for routine safety assurance. PMID:15795979

Pettauer, D; Käppeli, O; van den Eede, G

1998-06-01

189

Adverse drug reactions and safety considerations of NSAIDs: clinical analysis.  

PubMed

NSAIDs are the most frequently used drugs for treatment, in Europe and the United States, accounting for approximately 5% of all prescriptions. Moreover, the use of NSAIDs is increasing because these constitute the first-line drug therapy for a wide range of rheumatic conditions. This increase is in part the result of the increasing population of elderly patients, who constitute the group of patients with greatest demand for these agents. There are many types of NSAIDs that vary in potency, action and potential side effects. Thus various efforts have been made to determine the safety considerations including adverse drug effects, duration of drug therapy, drug interactions, precautions and other drugs applied to reduce side effects. Researchers have introduced some novel techniques to diagnose NSAIDs related adverse effects on the gastrointestinal mucosa. The researchers dealing with the development of drug delivery system for these drugs should aim at designing a therapeutically efficacious dosage form with reduced side/adverse effects. Thus an effort has been made in this review to deal with the safety parameters of various NSAIDs with a special emphasis on preclinical and clinical safety analysis and various attempts to minimize the side effects by structural modification or by drug delivery system. PMID:22424538

Bahadur, Shiv; Keshri, Lav; Pathak, Kamla

2011-11-01

190

Network analysis reveals patterns behind air safety events  

NASA Astrophysics Data System (ADS)

Complex networks have been extensively used to study the topological and dynamical characteristics of transportation systems, although far less attention has been devoted to the analysis of specific problems arising in everyday operations. In this work, the use of a network representation is proposed for studying the appearance of Loss of Separation events, a kind of safety occurrence in which two aircraft violate the minimal separation while airborne. The topological analysis of networks representing the structure of traffic flows allows identifying situations in which the probability of appearance of such events is increased. Beyond these specific results, this work demonstrates the usefulness of the complex network approach in the analysis of operational patterns and occurrences.

Zanin, Massimiliano

2014-05-01

191

Fault Tree Analysis Application for Safety and Reliability  

NASA Technical Reports Server (NTRS)

Many commercial software tools exist for fault tree analysis (FTA), an accepted method for mitigating risk in systems. The method embedded in the tools identifies a root as use in system components, but when software is identified as a root cause, it does not build trees into the software component. No commercial software tools have been built specifically for development and analysis of software fault trees. Research indicates that the methods of FTA could be applied to software, but the method is not practical without automated tool support. With appropriate automated tool support, software fault tree analysis (SFTA) may be a practical technique for identifying the underlying cause of software faults that may lead to critical system failures. We strive to demonstrate that existing commercial tools for FTA can be adapted for use with SFTA, and that applied to a safety-critical system, SFTA can be used to identify serious potential problems long before integrator and system testing.

Wallace, Dolores R.

2003-01-01

192

Ares I-X Malfunction Turn Range Safety Analysis  

NASA Technical Reports Server (NTRS)

Ares I-X was the designation given to the flight test version of the Ares I rocket which was developed by NASA (also known as the Crew Launch Vehicle (CLV) component of the Constellation Program). The Ares I-X flight test vehicle achieved a successful flight test on October 28, 2009, from Pad LC-39B at Kennedy Space Center, Florida (KSC). As part of the flight plan approval for the test vehicle, a range safety malfunction turn analysis was performed to support the risk assessment and vehicle destruct criteria development processes. Several vehicle failure scenarios were identified which could have caused the vehicle trajectory to deviate from its normal flight path. The effects of these failures were evaluated with an Ares I-X 6 degrees-of-freedom (6-DOF) digital simulation, using the Program to Optimize Simulated Trajectories Version II (POST2) simulation tool. The Ares I-X simulation analysis provided output files containing vehicle trajectory state information. These were used by other risk assessment and vehicle debris trajectory simulation tools to determine the risk to personnel and facilities in the vicinity of the launch area at KSC, and to develop the vehicle destruct criteria used by the flight test range safety officer in the event of a flight test anomaly of the vehicle. The simulation analysis approach used for this study is described, including descriptions of the failure modes which were considered and the underlying assumptions and ground rules of the study.

Beaty, J. R.

2011-01-01

193

The Zion integrated safety analysis for NUREG-1150  

SciTech Connect

The utility-funded Zion Probabilistic Safety Study provided not only a detailed and thorough assessment of the risk profile of Zion Unit 1, but also presented substantial advancement in the technology of probabilistic risk assessment (PRA). Since performance of that study, modifications of plant hardware, the introduction of new emergency procedures, operational experience gained, information generated by severe accident research programs and further evolution of PRA and uncertainty analysis methods have provided a basis for reevaluation of the Zion risk profile. This reevaluation is discussed in this report. 5 refs.

Unwin, S.D.; Park, C.K.

1988-01-01

194

Idaho National Engineering Laboratory (INEL) Environmental Restoration Program (ERP), Baseline Safety Analysis File (BSAF). Revision 1  

SciTech Connect

This document was prepared to take the place of a Safety Evaluation Report since the Baseline Safety Analysis File (BSAF)and associated Baseline Technical Safety Requirements (TSR) File do not meet the requirements of a complete safety analysis documentation. Its purpose is to present in summary form the background of how the BSAF and Baseline TSR originated and a description of the process by which it was produced and approved for use in the Environmental Restoration Program.The BSAF is a facility safety reference document for INEL environmental restoration activities including environmental remediation of inactive waste sites and decontamination and decommissioning (D&D) of surplus facilities. The BSAF contains safety bases common to environmental restoration activities and guidelines for performing and documenting safety analysis. The common safety bases can be incorporated by reference into the safety analysis documentation prepared for individual environmental restoration activities with justification and any necessary revisions. The safety analysis guidelines in BSAF provide an accepted method for hazard analysis; analysis of normal, abnormal, and accident conditions; human factors analysis; and derivation of TSRS. The BSAF safety bases and guidelines are graded for environmental restoration activities.

Not Available

1994-06-20

195

A diallel analysis of six components of partial resistance to Leptosphaeria nodorum in seedlings of six winter wheats  

E-print Network

A DIALLEL ANALYSIS OF SIX COMPONENTS OF PARTIAL RESISTANCE TO LEPTOSPHAERIA NODORUM IN SEEDLINGS OF SIX WINTER WHEATS A Thesis by HANS HENNING BRUNO Submitted to the Graduate College of of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE May 1987 Major Subject: Plant Breeding A DIALLEL ANALYSIS OF SIX COMPONENTS OF PARTIAL RESISTANCE TO LEPTOSPHAERIA NODORUM IN SEEDLINGS OF SIX WINTER WHEATS A Thesis by Hans Henning Bruno Approved...

Bruno, Hans Henning

1987-01-01

196

Survey of systems safety analysis methods and their application to nuclear waste management systems  

SciTech Connect

This report reviews system safety analysis methods and examines their application to nuclear waste management systems. The safety analysis methods examined include expert opinion, maximum credible accident approach, design basis accidents approach, hazard indices, preliminary hazards analysis, failure modes and effects analysis, fault trees, event trees, cause-consequence diagrams, G0 methodology, Markov modeling, and a general category of consequence analysis models. Previous and ongoing studies on the safety of waste management systems are discussed along with their limitations and potential improvements. The major safety methods and waste management safety related studies are surveyed. This survey provides information on what safety methods are available, what waste management safety areas have been analyzed, and what are potential areas for future study.

Pelto, P.J.; Winegardner, W.K.; Gallucci, R.H.V.

1981-11-01

197

10 CFR 70.62 - Safety program and integrated safety analysis.  

Code of Federal Regulations, 2011 CFR

...a Critical Mass of Special Nuclear Material § 70.62 Safety...radiological risk; (iv) Potential accident sequences caused by process...occurrence of each potential accident sequence identified pursuant...persons who have experience in nuclear criticality safety,...

2011-01-01

198

10 CFR 70.62 - Safety program and integrated safety analysis.  

Code of Federal Regulations, 2013 CFR

...a Critical Mass of Special Nuclear Material § 70.62 Safety...radiological risk; (iv) Potential accident sequences caused by process...occurrence of each potential accident sequence identified pursuant...persons who have experience in nuclear criticality safety,...

2013-01-01

199

10 CFR 70.62 - Safety program and integrated safety analysis.  

Code of Federal Regulations, 2012 CFR

...a Critical Mass of Special Nuclear Material § 70.62 Safety...radiological risk; (iv) Potential accident sequences caused by process...occurrence of each potential accident sequence identified pursuant...persons who have experience in nuclear criticality safety,...

2012-01-01

200

10 CFR 70.62 - Safety program and integrated safety analysis.  

Code of Federal Regulations, 2014 CFR

...a Critical Mass of Special Nuclear Material § 70.62 Safety...radiological risk; (iv) Potential accident sequences caused by process...occurrence of each potential accident sequence identified pursuant...persons who have experience in nuclear criticality safety,...

2014-01-01

201

Supplement to safety analysis report. 306-W building operations safety requirement  

SciTech Connect

The operations safety requirements (OSRs) presented in this report define the conditions, safe boundaries, and management control needed for safely conducting operations with radioactive materials in the Pacific Northwest Laboratory (PNL) 306-W building. The safety requirements are organized in five sections. Safety limits are safety-related process variables that are observable and measurable. Limiting conditions cover: equipment and technical conditions and characteristics of the facility and operations necessary for continued safe operation. Surveillance requirements prescribe the requirements for checking systems and components that are essential to safety. Equipment design controls require that changes to process equipment and systems be independently checked and approved to assure that the changes will have no adverse effect on safety. Administrative controls describe and discuss the organization and administrative systems and procedures to be used for safe operation of the facility. Details of the implementation of the operations safety requirements are prescribed by internal PNL documents such as criticality safety specifications and radiation work procedures.

Richey, C.R.

1979-08-01

202

PHYSICS AND SAFETY ANALYSIS FOR THE NIST RESEARCH REACTOR.  

SciTech Connect

Detailed reactor physics and safety analyses have been performed for the 20 MW D{sub 2}O moderated research reactor (NBSR) at the National Institute of Standards and Technology (NIST). The analyses provide an update to the Final Safety Analysis Report (FSAR) and employ state-of-the-art calculational methods. Three-dimensional Monte Carlo neutron and photon transport calculations were performed with the MCNP code to determine the safety parameters for the NBSR. The core depletion and determination of the fuel compositions were performed with MONTEBURNS. MCNP calculations were performed to determine the beginning, middle, and end-of-cycle power distributions, moderator temperature coefficient, and shim safety arm, beam tube and void reactivity worths. The calculational model included a plate-by-plate description of each fuel assembly, axial mid-plane water gap, beam tubes and the tubular geometry of the shim safety arms. The time-dependent analysis of the primary loop was determined with a RELAP5 transient analysis model that includes the pump, heat exchanger, fuel element geometry, and flow channels for both the six inner and twenty-four outer fuel elements. The statistical analysis used to assure protection from critical heat flux (CHF) was performed using a Monte Carlo simulation of the uncertainties contributing to the CHF calculation. The power distributions used to determine the local fuel conditions and margin to CHF were determined with MCNP. Evaluations were performed for the following accidents: (1) the control rod withdrawal startup accident, (2) the maximum reactivity insertion accident, (3) loss-of-flow resulting from loss of electrical power, (4) loss-of-flow resulting from a primary pump seizure, (5) loss-of-flow resulting from inadvertent throttling of a flow control valve, (6) loss-of-flow resulting from failure of both shutdown cooling pumps and (7) misloading of a fuel element. In both the startup and maximum reactivity insertion accidents, the core power transient is terminated by a reactor trip at 26 MW. The calculations show that both the peak reactor power and the excursion energy depend on the negative reactivity insertion from reactor trip. In one of the loss-of-flow accidents offsite electrical power is assumed lost to the three operating primary pumps. A slightly delayed reactor scram is initiated as a result of primary flow coast down. The RELAP5 results indicate that there is adequate margin to CHF and no damage to the fuel will occur, because of the momentum of the coolant flowing through the fuel channels and the negative scram reactivity insertion. For both the primary pump seizure and inadvertent throttling of a flow control valve, the RELAP5 analyses indicate that the reduction in power following the trip is sufficient to ensure that there is adequate margin to CHF and that the fuel cladding does not fail. The analysis of the loss-of-flow accident in the extremely unlikely case where both shutdown pumps fail, shows that the cooling provided by the D{sub 2}O is sufficient to ensure the cladding does not fail. The power distributions were examined for a set of fuel misloadings in which a fresh fuel element is moved from a peripheral low-reactivity location to a central high-reactivity location. The calculations show that there is adequate margin to CHF and the cladding does not fail. An additional analysis was performed to simulate the operation at low power (500 kW) without forced flow cooling. The result indicates that natural convection cooling is adequate for operation of the NBSR at a power level of 500 kW.

CHENG,L.HANSON,A.DIAMOND,D.XU,J.CAREW,J.RORER,D.

2004-03-31

203

Functional network connectivity analysis based on partial correlation in Alzheimer's disease  

NASA Astrophysics Data System (ADS)

Functional network connectivity (FNC) measures the temporal dependency among the time courses of functional networks. However, the marginal correlation between two networks used in the classic FNC analysis approach doesn't separate the FNC from the direct/indirect effects of other networks. In this study, we proposed an alternative approach based on partial correlation to evaluate the FNC, since partial correlation based FNC can reveal the direct interaction between a pair of networks, removing dependencies or influences from others. Previous studies have demonstrated less task-specific activation and less rest-state activity in Alzheimer's disease (AD). We applied present approach to contrast FNC differences of resting state network (RSN) between AD and normal controls (NC). The fMRI data under resting condition were collected from 15 AD and 16 NC. FNC was calculated for each pair of six RSNs identified using Group ICA, thus resulting in 15 (2 out of 6) pairs for each subject. Partial correlation based FNC analysis indicated 6 pairs significant differences between groups, while marginal correlation only revealed 2 pairs (involved in the partial correlation results). Additionally, patients showed lower correlation than controls among most of the FNC differences. Our results provide new evidences for the disconnection hypothesis in AD.

Zhang, Nan; Guan, Xiaoting; Zhang, Yumei; Li, Jingjing; Chen, Hongyan; Chen, Kewei; Fleisher, Adam; Yao, Li; Wu, Xia

2009-02-01

204

Partially coherent optical processor for enhancement of partial second order derivatives of an image: Analysis and implementation  

NASA Astrophysics Data System (ADS)

We present an optical processor capable to perform partial second derivatives of an image working with partially coherent illumination. The proposed system utilizes a liquid crystal display, onto which images to be derived are displayed. The method is based on the capacity of these devices to generate simultaneously a contrast reverted replica of the image displayed on it. A positive replica of original image is obtained when the LCD is between crossed polarizers, while the negative one is obtained with the LCD is between parallel polarizers. Since the LCD is a diffraction element, both polarizer arrangements may be simultaneously implemented, for example, in a 4 f optical processor using polarization filtering of the different diffraction orders. When three images (two replicas of original image displaced in opposite direction and the other one with contrast reverted and centered at the origin.) are imagined across a slightly defocused plane, one obtains an image with enhanced second derivatives in a given direction. No other incoherent (or partially coherent) optical system is presently known which can perform partial second-order derivatives of an image. Experimental results obtained are presented.

Flores, Jorge L.; Ferrari, José A.; Garcia-Torales, G.

2011-12-01

205

Analysis of Aviation Safety Reporting System Incident Data Associated With the Technical Challenges of the Vehicle Systems Safety Technology Project  

NASA Technical Reports Server (NTRS)

This analysis was conducted to support the Vehicle Systems Safety Technology (VSST) Project of the Aviation Safety Program (AVsP) milestone VSST4.2.1.01, "Identification of VSST-Related Trends." In particular, this is a review of incident data from the NASA Aviation Safety Reporting System (ASRS). The following three VSST-related technical challenges (TCs) were the focus of the incidents searched in the ASRS database: (1) Vechicle health assurance, (2) Effective crew-system interactions and decisions in all conditions; and (3) Aircraft loss of control prevention, mitigation, and recovery.

Withrow, Colleen A.; Reveley, Mary S.

2014-01-01

206

A Study on Urban Road Traffic Safety Based on Matter Element Analysis  

PubMed Central

This paper examines a new evaluation of urban road traffic safety based on a matter element analysis, avoiding the difficulties found in other traffic safety evaluations. The issue of urban road traffic safety has been investigated through the matter element analysis theory. The chief aim of the present work is to investigate the features of urban road traffic safety. Emphasis was placed on the construction of a criterion function by which traffic safety achieved a hierarchical system of objectives to be evaluated. The matter element analysis theory was used to create the comprehensive appraisal model of urban road traffic safety. The technique was used to employ a newly developed and versatile matter element analysis algorithm. The matter element matrix solves the uncertainty and incompatibility of the evaluated factors used to assess urban road traffic safety. The application results showed the superiority of the evaluation model and a didactic example was included to illustrate the computational procedure. PMID:25587267

Hu, Qizhou; Zhou, Zhuping; Sun, Xu

2014-01-01

207

Documented Safety Analysis for the B695 Segment  

SciTech Connect

This Documented Safety Analysis (DSA) was prepared for the Lawrence Livermore National Laboratory (LLNL) Building 695 (B695) Segment of the Decontamination and Waste Treatment Facility (DWTF). The report provides comprehensive information on design and operations, including safety programs and safety structures, systems and components to address the potential process-related hazards, natural phenomena, and external hazards that can affect the public, facility workers, and the environment. Consideration is given to all modes of operation, including the potential for both equipment failure and human error. The facilities known collectively as the DWTF are used by LLNL's Radioactive and Hazardous Waste Management (RHWM) Division to store and treat regulated wastes generated at LLNL. RHWM generally processes low-level radioactive waste with no, or extremely low, concentrations of transuranics (e.g., much less than 100 nCi/g). Wastes processed often contain only depleted uranium and beta- and gamma-emitting nuclides, e.g., {sup 90}Sr, {sup 137}Cs, or {sup 3}H. The mission of the B695 Segment centers on container storage, lab-packing, repacking, overpacking, bulking, sampling, waste transfer, and waste treatment. The B695 Segment is used for storage of radioactive waste (including transuranic and low-level), hazardous, nonhazardous, mixed, and other waste. Storage of hazardous and mixed waste in B695 Segment facilities is in compliance with the Resource Conservation and Recovery Act (RCRA). LLNL is operated by the Lawrence Livermore National Security, LLC, for the Department of Energy (DOE). The B695 Segment is operated by the RHWM Division of LLNL. Many operations in the B695 Segment are performed under a Resource Conservation and Recovery Act (RCRA) operation plan, similar to commercial treatment operations with best demonstrated available technologies. The buildings of the B695 Segment were designed and built considering such operations, using proven building systems, and keeping them as simple as possible while complying with industry standards and institutional requirements. No operations to be performed in the B695 Segment or building system are considered to be complex. No anticipated future change in the facility mission is expected to impact the extent of safety analysis documented in this DSA.

Laycak, D

2008-09-11

208

Safety analysis forseismic motion of control rods accounting for rod misalignment  

SciTech Connect

The purpose of this report is to provide a summary of the results of three safety analyses performed by the SRL Safety Analysis Group (SAG) to assess the safety impact of control rod motion induced by a Design Basis Earthquake (DBE).

Osmin, W.L.; Paik, I.K.

1992-01-01

209

White light source spectral domain OCT based on partial spectrum analysis  

Microsoft Academic Search

In order to enhance the longitudinal resolution and the signal to noise ratio (SNR) of Spectral domain OCT (SDOCT), a SDOCT using white light source is developed. By analyzing relationship between axial total number of pixels in the horizontal direction of CCD, spectrum of white-light source and longitudinal resolution, a white-light source SDOCT(WSSDOCT) based on partial spectrum analysis is developed

Nan Yao; Jin-Hai Wang; Yu Zheng

2009-01-01

210

Analysis of a local transient control action by partial energy functions  

SciTech Connect

Practical methods to compute and control transient stability are finally emerging in the electric power industry. These techniques are successful and can be used to analyze a wide variety of transient relationships. In this paper, a partial energy function is used to quantify the energy of a local transient control action. The function is used to analyze the energy transactions of a single generator in a multimachine system. This is in contrast with a global energy analysis of the system.

Stanton, S.E.; Dykas, W.P.

1989-08-01

211

Failure ofAll-ceramic Fixed Partial Dentures invitro andinvivo: Analysis andModeling  

Microsoft Academic Search

Hertzian conecracks visible attheloading site of20all- ceramic fixed partial dentures (FPDs), tested invitro, ledtothe hypotheses that failure wasduetothepropagation oflocalized contact damage crack systems (Hertzian stress state) andthat such damage wasanunlikely clinical failure mode. Fractographic analysis ofthe20laboratory-faile d andnineclinically-faile d all- ceramic FPDsallowed fordefinitive testing ofthese hypotheses andacomparison between invitro andinvivo failure behavior. In all cases, failure occurred intheFPDconnectors (none from

J. A. Teskl; A. Sorensen

212

Failure of All-ceramic Fixed Partial Dentures in vitro and in vivo: Analysis and Modeling  

Microsoft Academic Search

Hertzian cone cracks visible at the loading site of 20 all-ceramic fixed partial dentures (FPDs), tested in vitro, led to the hypotheses that failure was due to the propagation of localized contact damage crack systems (Hertzian stress state) and that such damage was an unlikely clinical failure mode. Fractographic analysis of the 20 laboratory-failed and nine clinically-failed all-ceramic FPDs allowed

J. R. Kelly; J. A. Tesk; J. A. Sorensen

1995-01-01

213

RISK PREDICTION OF A BEHAVIOR-BASED ADHESION CONTROL NETWORK FOR ONLINE SAFETY ANALYSIS OF  

E-print Network

. For wall-climbing robots safety is a main require- ment. The problem of terrain analysis is manageableRISK PREDICTION OF A BEHAVIOR-BASED ADHESION CONTROL NETWORK FOR ONLINE SAFETY ANALYSIS OF WALL-CLIMBING Algorithm : Behavior-Based : Risk Prediction : Climbing Robot Abstract: Risk analysis in combination

Berns, Karsten

214

Canister storage building (CSB) safety analysis report phase 3: Safety analysis documentation supporting CSB construction  

SciTech Connect

The Canister Storage Building (CSB) will be constructed in the 200 East Area of the U.S. Department of Energy (DOE) Hanford Site. The CSB will be used to stage and store spent nuclear fuel (SNF) removed from the Hanford Site K Basins. The objective of this chapter is to describe the characteristics of the site on which the CSB will be located. This description will support the hazard analysis and accident analyses in Chapter 3.0. The purpose of this report is to provide an evaluation of the CSB design criteria, the design's compliance with the applicable criteria, and the basis for authorization to proceed with construction of the CSB.

Garvin, L.J.

1997-04-28

215

Documented Safety Analysis for the Waste Storage Facilities  

SciTech Connect

This documented safety analysis (DSA) for the Waste Storage Facilities was developed in accordance with 10 CFR 830, Subpart B, 'Safety Basis Requirements', and utilizes the methodology outlined in DOE-STD-3009-94, Change Notice 3. The Waste Storage Facilities consist of Area 625 (A625) and the Decontamination and Waste Treatment Facility (DWTF) Storage Area portion of the DWTF complex. These two areas are combined into a single DSA, as their functions as storage for radioactive and hazardous waste are essentially identical. The B695 Segment of DWTF is addressed under a separate DSA. This DSA provides a description of the Waste Storage Facilities and the operations conducted therein; identification of hazards; analyses of the hazards, including inventories, bounding releases, consequences, and conclusions; and programmatic elements that describe the current capacity for safe operations. The mission of the Waste Storage Facilities is to safely handle, store, and treat hazardous waste, transuranic (TRU) waste, low-level waste (LLW), mixed waste, combined waste, nonhazardous industrial waste, and conditionally accepted waste generated at LLNL (as well as small amounts from other DOE facilities).

Laycak, D

2008-06-16

216

Documented Safety Analysis for the Waste Storage Facilities March 2010  

SciTech Connect

This Documented Safety Analysis (DSA) for the Waste Storage Facilities was developed in accordance with 10 CFR 830, Subpart B, 'Safety Basis Requirements,' and utilizes the methodology outlined in DOE-STD-3009-94, Change Notice 3. The Waste Storage Facilities consist of Area 625 (A625) and the Decontamination and Waste Treatment Facility (DWTF) Storage Area portion of the DWTF complex. These two areas are combined into a single DSA, as their functions as storage for radioactive and hazardous waste are essentially identical. The B695 Segment of DWTF is addressed under a separate DSA. This DSA provides a description of the Waste Storage Facilities and the operations conducted therein; identification of hazards; analyses of the hazards, including inventories, bounding releases, consequences, and conclusions; and programmatic elements that describe the current capacity for safe operations. The mission of the Waste Storage Facilities is to safely handle, store, and treat hazardous waste, transuranic (TRU) waste, low-level waste (LLW), mixed waste, combined waste, nonhazardous industrial waste, and conditionally accepted waste generated at LLNL (as well as small amounts from other DOE facilities).

Laycak, D T

2010-03-05

217

Hazard screening application guide. Safety Analysis Report Update Program  

SciTech Connect

The basic purpose of hazard screening is to group precesses, facilities, and proposed modifications according to the magnitude of their hazards so as to determine the need for and extent of follow on safety analysis. A hazard is defined as a material, energy source, or operation that has the potential to cause injury or illness in human beings. The purpose of this document is to give guidance and provide standard methods for performing hazard screening. Hazard screening is applied to new and existing facilities and processes as well as to proposed modifications to existing facilities and processes. The hazard screening process evaluates an identified hazards in terms of the effects on people, both on-site and off-site. The process uses bounding analyses with no credit given for mitigation of an accident with the exception of certain containers meeting DOT specifications. The process is restricted to human safety issues only. Environmental effects are addressed by the environmental program. Interfaces with environmental organizations will be established in order to share information.

none,

1992-06-01

218

Simplifying documentation while approaching site closure: integrated health & safety plans as documented safety analysis  

SciTech Connect

At the Fernald Closure Project (FCP) near Cincinnati, Ohio, environmental restoration activities are supported by Documented Safety Analyses (DSAs) that combine the required project-specific Health and Safety Plans, Safety Basis Requirements (SBRs), and Process Requirements (PRs) into single Integrated Health and Safety Plans (I-HASPs). By isolating any remediation activities that deal with Enriched Restricted Materials, the SBRs and PRs assure that the hazard categories of former nuclear facilities undergoing remediation remain less than Nuclear. These integrated DSAs employ Integrated Safety Management methodology in support of simplified restoration and remediation activities that, so far, have resulted in the decontamination and demolition (D&D) of over 150 structures, including six major nuclear production plants. This paper presents the FCP method for maintaining safety basis documentation, using the D&D I-HASP as an example.

Brown, Tulanda

2003-06-01

219

New Criticality Safety Analysis Capabilities in SCALE 5.1  

SciTech Connect

Version 5.1 of the SCALE computer software system developed at Oak Ridge National Laboratory, released in 2006, contains several significant enhancements for nuclear criticality safety analysis. This paper highlights new capabilities in SCALE 5.1, including improved resonance self-shielding capabilities; ENDF/B-VI.7 cross-section and covariance data libraries; HTML output for KENO V.a; analytical calculations of KENO-VI volumes with GeeWiz/KENO3D; new CENTRMST/PMCST modules for processing ENDF/B-VI data in TSUNAMI; SCALE Generalized Geometry Package in NEWT; KENO Monte Carlo depletion in TRITON; and plotting of cross-section and covariance data in Javapeno.

Bowman, Stephen M [ORNL; DeHart, Mark D [ORNL; Dunn, Michael E [ORNL; Goluoglu, Sedat [ORNL; Horwedel, James E [ORNL; Petrie Jr, Lester M [ORNL; Rearden, Bradley T [ORNL; Williams, Mark L [ORNL

2007-01-01

220

Safety analysis report for packaging (onsite) doorstop samplecarrier system  

SciTech Connect

The Doorstop Sample Carrier System consists of a Type B certified N-55 overpack, U.S. Department of Transportation (DOT) specification or performance-oriented 208-L (55-gal) drum (DOT 208-L drum), and Doorstop containers. The purpose of the Doorstop Sample Carrier System is to transport samples onsite for characterization. This safety analysis report for packaging (SARP) provides the analyses and evaluation necessary to demonstrate that the Doorstop Sample Carrier System meets the requirements and acceptance criteria for both Hanford Site normal transport conditions and accident condition events for a Type B package. This SARP also establishes operational, acceptance, maintenance, and quality assurance (QA) guidelines to ensure that the method of transport for the Doorstop Sample Carrier System is performed safely in accordance with WHC-CM-2-14, Hazardous Material Packaging and Shipping.

Obrien, J.H.

1997-02-24

221

Planning Document for an NBSR Conversion Safety Analysis Report  

SciTech Connect

The NIST Center for Neutron Research (NCNR) is a reactor-laboratory complex providing the National Institute of Standards and Technology (NIST) and the nation with a world-class facility for the performance of neutron-based research. The heart of this facility is the National Bureau of Standards Reactor (NBSR). The NBSR is a heavy water moderated and cooled reactor operating at 20 MW. It is fueled with high-enriched uranium (HEU) fuel elements. A Global Threat Reduction Initiative (GTRI) program is underway to convert the reactor to low-enriched uranium (LEU) fuel. This program includes the qualification of the proposed fuel, uranium and molybdenum alloy foil clad in an aluminum alloy, and the development of the fabrication techniques. This report is a planning document for the conversion Safety Analysis Report (SAR) that would be submitted to, and approved by, the Nuclear Regulatory Commission (NRC) before the reactor could be converted.This report follows the recommended format and content from the NRC codified in NUREG-1537, “Guidelines for Preparing and Reviewing Applications for the Licensing of Non-power Reactors,” Chapter 18, “Highly Enriched to Low-Enriched Uranium Conversions.” The emphasis herein is on the SAR chapters that require significant changes as a result of conversion, primarily Chapter 4, Reactor Description, and Chapter 13, Safety Analysis. The document provides information on the proposed design for the LEU fuel elements and identifies what information is still missing. This document is intended to assist ongoing fuel development efforts, and to provide a platform for the development of the final conversion SAR. This report contributes directly to the reactor conversion pillar of the GTRI program, but also acts as a boundary condition for the fuel development and fuel fabrication pillars.

Diamond D. J.; Baek J.; Hanson, A.L.; Cheng, L-Y.; Brown, N.; Cuadra, A.

2013-09-25

222

Safety analysis of the 700-horsepower combustion test facility  

SciTech Connect

The objective of the program reported herein was to provide a Safety Analysis of the 700 h.p. Combustion Test Facility located in Building 93 at the Pittsburgh Energy Technology Center. Extensive safety related measures have been incorporated into the design, construction, and operation of the Combustion Test Facility. These include: nitrogen addition to the coal storage bin, slurry hopper, roller mill and pulverizer baghouse, use of low oxygen content combustion gas for coal conveying, an oxygen analyzer for the combustion gas, insulation on hot surfaces, proper classification of electrical equipment, process monitoring instrumentation and a planned remote television monitoring system. Analysis of the system considering these factors has resulted in the determination of overall probabilities of occurrence of hazards as shown in Table I. Implementation of the recommendations in this report will reduce these probabilities as indicated. The identified hazards include coal dust ignition by hot ductwork and equipment, loss of inerting within the coal conveying system leading to a coal dust fire, and ignition of hydrocarbon vapors or spilled oil, or slurry. The possibility of self-heating of coal was investigated. Implementation of the recommendations in this report will reduce the ignition probability to no more than 1 x 10/sup -6/ per event. In addition to fire and explosion hazards, there are potential exposures to materials which have been identified as hazardous to personal health, such as carbon monoxide, coal dust, hydrocarbon vapors, and oxygen deficient atmosphere, but past monitoring experience has not revealed any problem areas. The major environmental hazard is an oil spill. The facility has a comprehensive spill control plan.

Berkey, B.D.

1981-05-01

223

Partial-wave analysis of particular peaks in total scattering cross sections caused by a single partial wave  

NASA Astrophysics Data System (ADS)

Certain broad low-energy peaks in the total cross sections relevant for electron-atom scattering are studied and found to be caused by a single partial wave. Such peaks are associated here with complex orbital angular momentum (Regge) pole trajectories. At the peak energies these S-matrix poles are in some neighborhood of an integer value and at the same time near its maximum real part value as a function of energy. Such peaks are found to have no time delays. Results are presented for the Dirac equation using three rational function Thomas-Fermi potential models, all with the same behavior at large and small radial distances.

Thylwe, Karl-Erik; McCabe, Patrick

2014-10-01

224

Analysis of School Food Safety Programs Based on HACCP Principles  

ERIC Educational Resources Information Center

Purpose/Objectives: The purpose of this study was to determine how school districts have implemented food safety programs based on HACCP principles. Specific objectives included: (1) Evaluate how schools are implementing components of food safety programs; and (2) Determine foodservice employees food-handling practices related to food safety.…

Roberts, Kevin R.; Sauer, Kevin; Sneed, Jeannie; Kwon, Junehee; Olds, David; Cole, Kerri; Shanklin, Carol

2014-01-01

225

Analysis techniques for airborne laser range safety evaluations  

Microsoft Academic Search

Techniques to evaluate safety of airborne laser operations on the range are reported. The objectives of the safety evaluations were to (1) protect civilian and military personnel from the hazards associated with lasers, (2) provide users with the least restrictive constraints in which to perform their mission and still maintain an adequate degree of safety, and (3) develop a data

M. S. Ramsburg; D. L. Jenkins; R. D. Doerflein

1982-01-01

226

Safety review of the design, operation, and radiation sections of the General Electric Morris Operation Consolidated Safety Analysis Report  

SciTech Connect

A safety review was made of Sections 4 through 9 of the Consolidated Safety Analysis Report (CSAR) for the GE Morris Operation spent-fuel storage facility. The sections reviewed include Design Criteria and Compliance, Facility Design and Description, Radiation Protection, Accident Analysis, and Conduct of Operations. The safety review was performed in accordance with the Code of Federal Regulations, Title 10, Part 72, ''Licensing Requirements for the Storage of Spent Fuel in an Independent Spent Fuel Storage Installation'' and contains independent estimations of source terms and dose-commitments from postulated accidents in the storage facility and a structural analysis of the Morris Operation cranes as an appendix. The review confirms that the features of the facility as described in Sections 4 through 9 of the CSAR fulfilled the safety requirements of 10 CFR 72, and it is concluded that spent-fuel handling and storage at the Morris Operation do not present significant risks to public health and safety. 15 refs., 3 tabs.

McBride, J.P.

1981-01-30

227

Fault tree synthesis for software design analysis of PLC based safety-critical systems  

SciTech Connect

As a software verification and validation should be performed for the development of PLC based safety-critical systems, a software safety analysis is also considered in line with entire software life cycle. In this paper, we propose a technique of software safety analysis in the design phase. Among various software hazard analysis techniques, fault tree analysis is most widely used for the safety analysis of nuclear power plant systems. Fault tree analysis also has the most intuitive notation and makes both qualitative and quantitative analyses possible. To analyze the design phase more effectively, we propose a technique of fault tree synthesis, along with a universal fault tree template for the architecture modules of nuclear software. Consequently, we can analyze the safety of software on the basis of fault tree synthesis. (authors)

Koo, S. R.; Cho, C. H. [Corporate R and D Inst., Doosan Heavy Industries and Construction Co., Ltd., 39-3, Seongbok-Dong, Yongin-Si, Gyeonggi-Do 449-795 (Korea, Republic of); Seong, P. H. [Dept. of Nuclear and Quantum Engineering, Korea Advanced Inst. of Science and Technology, 373-3 Guseong-dong, Yuseong-gu, Daejeon, 305-701 (Korea, Republic of)

2006-07-01

228

PHYSICS AND SAFETY ANALYSIS FOR THE NIST RESEARCH REACTOR.  

SciTech Connect

Detailed reactor physics and safety analyses have been performed for the 20 MW D{sub 2}O moderated research reactor (NBSR) at the National Institute of Standards and Technology (NIST). The analyses provide an update to the Final Safety Analysis Report (FSAR) and employ state-of-the-art calculational methods. Three-dimensional MCNP Monte Carlo neutron and photon transport calculations were performed to determine the safety parameters for the NBSR. The core depletion and determination of the fuel compositions were performed with MONTEBURNS. MCNP calculations were performed to determine the beginning, middle, and end-of-cycle power distributions, moderator temperature coefficient, and shim arm, beam tube and void reactivity worths. The calculational model included a plate-by-plate description of each fuel assembly, axial mid-plane water gap, beam tubes and the tubular geometry of the shim arms. The time-dependent analysis of the primary loop was determined with a RELAP5 transient analysis model including the pump, heat exchanger, fuel element geometry, and flow channels for both the six inner and twenty-four outer fuel elements. The statistical analysis used to assure protection from critical heat flux (CHF) was performed using a Monte Carlo simulation of the uncertainties contributing to the CHF calculation. The power distributions used to determine the local fuel conditions and margin to CHF were determined with MCNP. Evaluations were performed for the following accidents: (1) the control rod withdrawal startup accident, (2) the maximum reactivity insertion accident, (3) loss-of-flow resulting from loss of electrical power, (4) loss-of-flow resulting from a primary pump seizure, (5) loss-of-flow resulting from inadvertent throttling of a flow control valve, (6) loss-of-flow resulting from failure of both shutdown cooling pumps and (7) misloading of a fuel element. In both the startup and maximum reactivity insertion accidents, the core power transient is terminated by a reactor trip at 30 MW. The calculations show that both the peak reactor power and the excursion energy depend on the negative reactivity insertion from reactor trip. Two cases were considered for loss of electrical power. In the first case offsite power is lost, resulting in an immediate scram caused by loss of power to the control rod system. In the second case power is lost to only the three operating primary pumps, resulting in a slightly delayed scram when loss-of-flow is detected as the pumps coast down. In both instances, RELAP5 results indicate that there is adequate margin to CHF and no damage to the fuel will occur, because of the momentum of the coolant flowing through the fuel channels and the negative scram reactivity insertion. For both the primary pump seizure and inadvertent throttling of a flow control valve, the RELAP5 analyses indicate that the reduction in power following the trip is sufficient to ensure that there is adequate margin to CHF and the fuel cladding does not fail. The analysis of the loss-of-flow accident in the extremely unlikely case where both shutdown pumps fail shows that the cooling provided by the D{sub 2}O is sufficient to ensure the cladding does not fail. The power distributions were examined for a set of fuel misloadings in which a fresh fuel element is moved from a peripheral low-reactivity location to a central high-reactivity location. The calculations show that there is adequate margin to CHF and the cladding does not fail.

CAREW,J.CHENG,L.HANSON,AXU,J.RORER,D.DIAMOND,D.

2003-08-26

229

Formal Safety analysis of a radio-based railroad crossing using Deductive Cause-Consequence  

E-print Network

Formal Safety analysis of a radio-based railroad crossing using Deductive Cause}@informatik.uni-augsburg.de Abstract. In this paper we present the formal safety analysis of a radio- based railroad crossing. We use: a radio-based railroad crossing. We illustrate the results of DCCA for this example and compare them

Reif, Wolfgang

230

Formal Safety analysis of a radiobased railroad crossing using Deductive CauseConsequence  

E-print Network

Formal Safety analysis of a radio­based railroad crossing using Deductive Cause}@informatik.uni­augsburg.de Abstract. In this paper we present the formal safety analysis of a radio­ based railroad crossing. We use­based railroad crossing. We illustrate the results of DCCA for this example and compare them to results of other

Reif, Wolfgang

231

Interface design of VSOP'94 computer code for safety analysis  

NASA Astrophysics Data System (ADS)

Today, most software applications, also in the nuclear field, come with a graphical user interface. VSOP'94 (Very Superior Old Program), was designed to simplify the process of performing reactor simulation. VSOP is a integrated code system to simulate the life history of a nuclear reactor that is devoted in education and research. One advantage of VSOP program is its ability to calculate the neutron spectrum estimation, fuel cycle, 2-D diffusion, resonance integral, estimation of reactors fuel costs, and integrated thermal hydraulics. VSOP also can be used to comparative studies and simulation of reactor safety. However, existing VSOP is a conventional program, which was developed using Fortran 65 and have several problems in using it, for example, it is only operated on Dec Alpha mainframe platforms and provide text-based output, difficult to use, especially in data preparation and interpretation of results. We develop a GUI-VSOP, which is an interface program to facilitate the preparation of data, run the VSOP code and read the results in a more user friendly way and useable on the Personal 'Computer (PC). Modifications include the development of interfaces on preprocessing, processing and postprocessing. GUI-based interface for preprocessing aims to provide a convenience way in preparing data. Processing interface is intended to provide convenience in configuring input files and libraries and do compiling VSOP code. Postprocessing interface designed to visualized the VSOP output in table and graphic forms. GUI-VSOP expected to be useful to simplify and speed up the process and analysis of safety aspects.

Natsir, Khairina; Yazid, Putranto Ilham; Andiwijayakusuma, D.; Wahanani, Nursinta Adi

2014-09-01

232

Interface design of VSOP'94 computer code for safety analysis  

SciTech Connect

Today, most software applications, also in the nuclear field, come with a graphical user interface. VSOP'94 (Very Superior Old Program), was designed to simplify the process of performing reactor simulation. VSOP is a integrated code system to simulate the life history of a nuclear reactor that is devoted in education and research. One advantage of VSOP program is its ability to calculate the neutron spectrum estimation, fuel cycle, 2-D diffusion, resonance integral, estimation of reactors fuel costs, and integrated thermal hydraulics. VSOP also can be used to comparative studies and simulation of reactor safety. However, existing VSOP is a conventional program, which was developed using Fortran 65 and have several problems in using it, for example, it is only operated on Dec Alpha mainframe platforms and provide text-based output, difficult to use, especially in data preparation and interpretation of results. We develop a GUI-VSOP, which is an interface program to facilitate the preparation of data, run the VSOP code and read the results in a more user friendly way and useable on the Personal 'Computer (PC). Modifications include the development of interfaces on preprocessing, processing and postprocessing. GUI-based interface for preprocessing aims to provide a convenience way in preparing data. Processing interface is intended to provide convenience in configuring input files and libraries and do compiling VSOP code. Postprocessing interface designed to visualized the VSOP output in table and graphic forms. GUI-VSOP expected to be useful to simplify and speed up the process and analysis of safety aspects.

Natsir, Khairina, E-mail: yenny@batan.go.id; Andiwijayakusuma, D.; Wahanani, Nursinta Adi [Center for Development of Nuclear Informatics - National Nuclear Energy Agency, PUSPIPTEK, Serpong, Tangerang, Banten (Indonesia); Yazid, Putranto Ilham [Center for Nuclear Technology, Material and Radiometry- National Nuclear Energy Agency, Jl. Tamansari No.71, Bandung 40132 (Indonesia)

2014-09-30

233

Criticality safety analysis on fissile materials in Fukushima reactor cores  

SciTech Connect

The present study focuses on the criticality analysis for geological disposal of damaged fuels from Fukushima reactor cores. Starting from the basic understanding of behaviors of plutonium and uranium, a scenario sequence for criticality event is considered. Due to the different mobility of plutonium and uranium in geological formations, the criticality safety is considered in two parts: (1) near-field plutonium system and (2) far-field low enriched uranium (LEU) system. For the near-field plutonium system, a mathematical analysis for pure-solute transport was given, assuming a particular buffer material and waste form configuration. With the transport and decay of plutonium accounted, the critical mass of plutonium was compared with the initial load of a single canister. Our calculation leads us to the conclusion that our system with the initial loading being the average mass of plutonium in an assembly just before the accident is very unlikely to become critical over time. For the far-field LEU system, due to the uncertainties in the geological and geochemical conditions, calculations were made in a parametric space that covers the variation of material compositions and different geometries. Results show that the LEU system could not remain sub-critical within the entire parameter space assumed, although in the iron-rich rock, the neutron multiplicity is significantly reduced.

Liu, Xudong; Lemaitre-Xavier, E.; Ahn, Joonhong [Department of Nuclear Engineering, University of California, Berkeley, Berkeley, CA 94720 (United States); Hirano, Fumio [Japan Atomic Energy Agency, Geological Isolation Research and Development Directorate, Tokai-mura, Ibaraki 319-1194 (Japan)

2013-07-01

234

Inter-class Def-Use Analysis with Partial Class Representations * Amie L. Souter and Lori L. Pollock  

E-print Network

Inter-class Def-Use Analysis with Partial Class Representations * Amie L. Souter and Lori L on the first page. To copy otherwise, to republish, to post on servers or to redistribute to lists, requires

Pollock, Lori L.

235

Partial wave analysis of J\\/\\\\psi \\\\to \\\\gamma \\\\phi \\\\phi  

Microsoft Academic Search

Using $5.8 \\\\times 10^7 J\\/\\\\psi$ events collected in the BESII detector, the\\u000aradiative decay $J\\/\\\\psi \\\\to \\\\gamma \\\\phi \\\\phi \\\\to \\\\gamma K^+ K^- K^0_S K^0_L$ is\\u000astudied. The $\\\\phi\\\\phi$ invariant mass distribution exhibits a near-threshold\\u000aenhancement that peaks around 2.24 GeV\\/$c^{2}$.\\u000a A partial wave analysis shows that the structure is dominated by a $0^{-+}$\\u000astate ($\\\\eta(2225)$) with a mass of

J. Z. Bai; Y. Bai; Y. Ban; X. Cai; H. F. Chen; H. S. Chen; H. X. Chen; J. C. Chen; X. D. Chen; Y. B. Chen; Y. P. Chu; Y. S. Dai; Z. Y. Deng; J. Fang; C. D. Fu; C. S. Gao; Y. N. Gao; S. D. Gu; Y. T. Gu; Y. N. Guo; Z. J. Guo; F. A. Harris; K. L. He; Y. K. Heng; J. Hou; H. M. Hu; T. Hu; G. S. Huang; X. T. Huang; Y. P. Huang; X. B. Ji; X. S. Jiang; J. B. Jiao; D. P. Jin; S. Jin; Y. F. Lai; H. B. Li; J. Li; R. Y. Li; W. D. Li; W. G. Li; X. L. Li; X. N. Li; X. Q. Li; Y. F. Liang; H. B. Liao; B. J. Liu; C. X. Liu; Fang Liu; Feng Liu; H. H. Liu; H. M. Liu; J. B. Liu; H. B. Liu; J. Liu; Q. Liu; R. G. Liu; S. Liu; Z. A. Liu; F. Lu; G. R. Lu; J. G. Lu; C. L. Luo; H. L. Ma; L. L. Ma; Q. M. Ma; M. Q. A. Malik; Z. P. Mao; X. H. Mo; J. Nie; S. L. Olsen; R. G. Ping; N. D. Qi; H. Qin; J. F. Qiu; G. Rong; X. D. Ruan; L. Y. Shan; L. Shang; C. P. Shen; D. L. Shen; X. Y. Shen; H. Y. Sheng; H. S. Sun; S. S. Sun; Y. Z. Sun; Z. J. Sun; X. Tang; J. P. Tian; G. L. Tong; G. S. Varner; X. Wan; L. Wang; L. S. Wang; P. Wang; W. F. Wang; Y. F. Wang; Z. Wang; C. L. Wei; D. H. Wei; Y. Weng; N. Wu; X. M. Xia; X. X. Xie; G. F. Xu; X. P. Xu; Y. Xu; M. L. Yan; H. X. Yang; M. Yang; Y. X. Yang; M. H. Ye; Y. X. Ye; C. X. Yu; G. W. Yu; C. Z. Yuan; Y. Yuan; S. L. Zang; Y. Zeng; B. X. Zhang; C. C. Zhang; D. H. Zhang; H. Q. Zhang; H. Y. Zhang; J. W. Zhang; J. Y. Zhang; X. Y. Zhang; Y. Y. Zhang; Z. X. Zhang; Z. P. Zhang; D. X. Zhao; J. W. Zhao; M. G. Zhao; P. P. Zhao; Z. G. Zhao; H. Q. Zheng; J. P. Zheng; Z. P. Zheng; B. Zhong; L. Zhou; K. J. Zhu; Q. M. Zhu; X. W. Zhu; Y. C. Zhu; Y. S. Zhu; Z. A. Zhu; Z. L. Zhu; B. A. Zhuang

2008-01-01

236

Thermal stress analysis of partially absorbing brittle ceramics subjected to symmetric radiation heating  

SciTech Connect

An analysis is presented of the thermal stresses in partially absorbing ceramics, in the form of flat plates symmetrically heated by thermal radiation and cooled by convection. The absorption coefficient is introduced as a material property, which affects thermal stress resistance. For zero heat transfer coefficient and optical thickness ..mu..a ..-->.. 0 the tensile thermal stresses are proportional to (..mu..a)/sup 3/. For h = varies as and ..mu..a ..-->.. 0, the tensile thermal stresses are a linear function of ..mu..a. Appropriate thermal stress resistance parameters were derived.

Hasselman, D.P.H.; Thomas, J.R. Jr.; Kamat, M.P.; Satyamurthy, K.

1980-01-01

237

Analysis of partial coherence in grating-based phase-contrast X-ray imaging  

NASA Astrophysics Data System (ADS)

We report here a quantitative analysis of the effect of partial coherence on grating-based phase-contrast X-ray imaging. The self-image intensity has been derived through the phase-space formulation in the framework of the Wigner distribution. Based on the behavior of the self-image visibility, the minimum required spatial coherence length is given for three different types of gratings. Furthermore, we show that the coherence requirement, at different fractional Talbot distances, increases linearly with the Talbot order for the three types of gratings. The approach we presented can also be successfully applied to the Talbot-Lau geometry.

Wang, Zhili; Liu, Xiaosong; Zhu, Peiping; Huang, Wanxia; Yuan, Qingxi; Li, Enrong; Liu, Yijin; Zhang, Kai; Hong, Youli; Wu, Ziyu

2010-07-01

238

Analysis of factors affecting the performance of partial nitrification in a sequencing batch reactor.  

PubMed

The objective of this study was to analyze the factors affecting the performance of partial nitrification in a sequencing batch reactor. During a 140-day long-term operation, influent pH value, dissolved oxygen (DO), and chemical oxygen demand/nitrogen (COD/N) ratio were selected as operating factors to evaluate the maintenance and recovery of nitrite accumulation. Results showed that high DO concentration (2-4 mg/L) could damage nitrite accumulation immediately. However, nitrite accumulation ratio (NAR) could be increased from 1.68 ± 1.51 to 35.46 ± 7.86% when increasing the pH values from 7.5 to 8.3 due to the increased free ammonia concentration. Afterwards, stable partial nitrification and high NAR could be recovered when the reactor operated under low DO concentration (0.5-1.0 mg/L). However, it required a long time to recover the partial nitrification of the reactor when the influent COD/N ratios were altered. Fluorescence in situ hybridization analysis implied that ammonium oxidizing bacteria were completely recovered to the dominant nitrifying bacteria in the system. Meanwhile, sludge volumetric index of the reactor gradually decreased from 115.6 to 56.6 mL/g, while the mean diameter of sludge improved from 74.57 to 428.8 ?m by using the strategy of reducing settling time. The obtained results could provide useful information between the operational conditions and the performance of partial nitrification when treating nitrogen-rich industrial wastewater. PMID:23942879

Wei, Dong; Du, Bin; Xue, Xiaodong; Dai, Peng; Zhang, Jian

2014-02-01

239

Analysis of effect of flameholder characteristics on lean, premixed, partially vaporized fuel-air mixtures quality and nitrogen oxides emissions  

NASA Technical Reports Server (NTRS)

An analysis was conducted of the effect of flameholding devices on the precombustion fuel-air characteristics and on oxides of nitrogen (NOx) emissions for combustion of premixed partially vaporized mixtures. The analysis includes the interrelationships of flameholder droplet collection efficiency, reatomization efficiency and blockage, and the initial droplet size distribution and accounts for the contribution of droplet combustion in partially vaporized mixtures to NOx emissions. Application of the analytical procedures is illustrated and parametric predictions of NOx emissions are presented.

Cooper, L. P.

1981-01-01

240

Providing Nuclear Criticality Safety Analysis Education through Benchmark Experiment Evaluation  

SciTech Connect

One of the challenges that today's new workforce of nuclear criticality safety engineers face is the opportunity to provide assessment of nuclear systems and establish safety guidelines without having received significant experience or hands-on training prior to graduation. Participation in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and/or the International Reactor Physics Experiment Evaluation Project (IRPhEP) provides students and young professionals the opportunity to gain experience and enhance critical engineering skills.

John D. Bess; J. Blair Briggs; David W. Nigg

2009-11-01

241

Upgrade Uranium Recovery Project No. 34110: final safety analysis report  

SciTech Connect

The accident analysis of the upgrade uranium recovery system indicated three potential hazards: (1) criticality, (2) toxic fumes from nitric acid solutions, and (3) release of toxic uranyl nitrate solutions. Any of these are capable of causing the death of one or more employees; therefore, they form the basis for the residual risks identified below. The analysis found no hazardous energies or substances capable of causing irreversible injury to, or the death of, any members of the public. The following residual risks will be controlled administratively by procedural constraints: An operator or maintenance error will cause /sup 235/U to be transferred into an unsafe container and cause a criticality. An operator or maintenance error will cause containers of /sup 235/U bearing material to be improperly spaced and cause a criticality. Extensive corrosion will cause a hole to form in a calciner tube, the corrosion will go undetected, and a criticality will result, and a loss of system and/or building solution containment will occur concurrent with a drain being open resulting in a criticality and/or release of toxic material. Additional residual risks that have a small probability are that an earthquake or tornado will affect the building, alter the system geometry, and initiate a criticality; that the compressed-gas (nitrogen) cylinder valve will be sheared off, become airborne, and alter the system geometry; and that loss of system and/or building solution containment may occur concurrently with fire sprinkler system actuation causing a criticality and/or release of toxic material. The following residual risks will be addressed in the Safety Study of the existing X-705 Building: that a spill of raffinate highly contaminated with /sup 99/Tc will occur due to operator error or incorrect lab analysis and that a gaseous or liquid effluent release of small amounts of transuranic elements will occur.

Not Available

1981-09-01

242

Packaging Review Guide for Reviewing Safety Analysis Reports for Packagings  

SciTech Connect

This Packaging Review Guide (PRG) provides guidance for Department of Energy (DOE) review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE Order 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his or her review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. This PRG is generally organized at the section level in a format similar to that recommended in Regulatory Guide 7.9 (RG 7.9). One notable exception is the addition of Section 9 (Quality Assurance), which is not included as a separate chapter in RG 7.9. Within each section, this PRG addresses the technical and regulatory bases for the review, the manner in which the review is accomplished, and findings that are generally applicable for a package that meets the approval standards. This Packaging Review Guide (PRG) provides guidance for DOE review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE O 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. The primary objectives of this PRG are to: (1) Summarize the regulatory requirements for package approval; (2) Describe the technical review procedures by which DOE determines that these requirements have been satisfied; (3) Establish and maintain the quality and uniformity of reviews; (4) Define the base from which to evaluate proposed changes in scope and requirements of reviews; and (5) Provide the above information to DOE organizations, contractors, other government agencies, and interested members of the general public. This PRG was originally published in September 1987. Revision 1, issued in October 1988, added new review sections on quality assurance and penetrations through the containment boundary, along with a few other items. Revision 2 was published October 1999. Revision 3 of this PRG is a complete update, and supersedes Revision 2 in its entirety.

DiSabatino, A; Biswas, D; DeMicco, M; Fisher, L E; Hafner, R; Haslam, J; Mok, G; Patel, C; Russell, E

2007-04-12

243

Idaho National Engineering Laboratory (INEL) Environmental Restoration (ER) Program Baseline Safety Analysis File (BSAF)  

SciTech Connect

The Baseline Safety Analysis File (BSAF) is a facility safety reference document for the Idaho National Engineering Laboratory (INEL) environmental restoration activities. The BSAF contains information and guidance for safety analysis documentation required by the U.S. Department of Energy (DOE) for environmental restoration (ER) activities, including: Characterization of potentially contaminated sites. Remedial investigations to identify and remedial actions to clean up existing and potential releases from inactive waste sites Decontamination and dismantlement of surplus facilities. The information is INEL-specific and is in the format required by DOE-EM-STD-3009-94, Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports. An author of safety analysis documentation need only write information concerning that activity and refer to BSAF for further information or copy applicable chapters and sections. The information and guidance provided are suitable for: {sm_bullet} Nuclear facilities (DOE Order 5480-23, Nuclear Safety Analysis Reports) with hazards that meet the Category 3 threshold (DOE-STD-1027-92, Hazard Categorization and Accident Analysis Techniques for Compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports) {sm_bullet} Radiological facilities (DOE-EM-STD-5502-94, Hazard Baseline Documentation) Nonnuclear facilities (DOE-EM-STD-5502-94) that are classified as {open_quotes}low{close_quotes} hazard facilities (DOE Order 5481.1B, Safety Analysis and Review System). Additionally, the BSAF could be used as an information source for Health and Safety Plans and for Safety Analysis Reports (SARs) for nuclear facilities with hazards equal to or greater than the Category 2 thresholds, or for nonnuclear facilities with {open_quotes}moderate{close_quotes} or {open_quotes}high{close_quotes} hazard classifications.

NONE

1995-09-01

244

Preparation and application of a partially degradable gel in mass spectrometry-based proteomic analysis.  

PubMed

In-gel digestion is an attractive route in mass spectrometry-based proteomic analysis, which, however, often suffers from a certain amount of sample loss mainly due to insufficient protein digestion and peptide extraction. To address this, herein we establish a partially degradable gel-assisted protein digestion and peptide recovery method by means of a simple replacement of bis-acrylamide (BA) with bis-acrylylcystamine (BAC). Concretely, the protein sample solubilized using high concentrations of sodium dodecyl sulfate (SDS) and urea were directly entrapped and immobilized into BAC-crosslinked gel by vacuum-dried gel absorption followed by fixation treatment. After removal of SDS and urea by repeated washing, the proteins were subjected to in-gel digestion and the gel was reductively treated. The tryptic peptides were recovered from the partial degradation of the gel and analyzed afterwards by capillary liquid chromatography coupled with tandem mass spectrometry (CapLC-MS/MS). Compared with conventional BA-crosslinked gel method, this new method increased the numbers of identified proteins and unique peptides by 20.2% and 20.4%, respectively. The further statistical analysis demonstrated that the method improved the recovery of tryptic peptides particularly larger and/or hydrophobic peptides, thereby significantly facilitating protein identification. Thus, the newly developed method is a promising alternative for BA-crosslinked gel-based shotgun workflows and has potential application in the related fields of protein chemistry and proteomics. PMID:21920827

Zhou, Jian; Hu, Yongbo; Lin, Yong; Liu, Haipeng; Xie, Peng

2011-10-15

245

Detrended Partial-Cross-Correlation Analysis: A New Method for Analyzing Correlations in Complex System  

NASA Astrophysics Data System (ADS)

In this paper, a new method, detrended partial-cross-correlation analysis (DPCCA), is proposed. Based on detrended cross-correlation analysis (DCCA), this method is improved by including partial-correlation technique, which can be applied to quantify the relations of two non-stationary signals (with influences of other signals removed) on different time scales. We illustrate the advantages of this method by performing two numerical tests. Test I shows the advantages of DPCCA in handling non-stationary signals, while Test II reveals the ``intrinsic'' relations between two considered time series with potential influences of other unconsidered signals removed. To further show the utility of DPCCA in natural complex systems, we provide new evidence on the winter-time Pacific Decadal Oscillation (PDO) and the winter-time Nino3 Sea Surface Temperature Anomaly (Nino3-SSTA) affecting the Summer Rainfall over the middle-lower reaches of the Yangtze River (SRYR). By applying DPCCA, better significant correlations between SRYR and Nino3-SSTA on time scales of 6 ~ 8 years are found over the period 1951 ~ 2012, while significant correlations between SRYR and PDO on time scales of 35 years arise. With these physically explainable results, we have confidence that DPCCA is an useful method in addressing complex systems.

Yuan, Naiming; Fu, Zuntao; Zhang, Huan; Piao, Lin; Xoplaki, Elena; Luterbacher, Juerg

2015-01-01

246

Detrended partial-cross-correlation analysis: a new method for analyzing correlations in complex system.  

PubMed

In this paper, a new method, detrended partial-cross-correlation analysis (DPCCA), is proposed. Based on detrended cross-correlation analysis (DCCA), this method is improved by including partial-correlation technique, which can be applied to quantify the relations of two non-stationary signals (with influences of other signals removed) on different time scales. We illustrate the advantages of this method by performing two numerical tests. Test I shows the advantages of DPCCA in handling non-stationary signals, while Test II reveals the "intrinsic" relations between two considered time series with potential influences of other unconsidered signals removed. To further show the utility of DPCCA in natural complex systems, we provide new evidence on the winter-time Pacific Decadal Oscillation (PDO) and the winter-time Nino3 Sea Surface Temperature Anomaly (Nino3-SSTA) affecting the Summer Rainfall over the middle-lower reaches of the Yangtze River (SRYR). By applying DPCCA, better significant correlations between SRYR and Nino3-SSTA on time scales of 6 ~ 8 years are found over the period 1951 ~ 2012, while significant correlations between SRYR and PDO on time scales of 35 years arise. With these physically explainable results, we have confidence that DPCCA is an useful method in addressing complex systems. PMID:25634341

Yuan, Naiming; Fu, Zuntao; Zhang, Huan; Piao, Lin; Xoplaki, Elena; Luterbacher, Juerg

2015-01-01

247

A meta-analysis of bird responses to uniform partial harvesting across North America.  

PubMed

Most data on the effects of partial-harvest silviculture (where live trees are purposely retained at the time of harvest) on birds come from one or a few discrete harvesting treatments. It is thus difficult to infer species responses across a continuous gradient of tree retention from individual studies. To quantify the levels of tree retention expected to produce specified changes in the relative abundance of individual species, we carried out a meta-analysis of 42 studies that examined the impacts of uniform partial harvesting on North American birds. Of 34 species, sigmoidal models showed a negative effect of harvesting for 14 species and a positive effect for 6 species. Ovenbirds (Seiurus aurocapilla) and Brown Creepers (Certhia americana) were the species most sensitive to harvesting. Most of the 14 species that were negatively affected by harvesting showed 25%, 50%, and 75% reductions in abundance (relative to control sites) at tree retention levels ranging from 45 to 85%, 30-70%, and 15-50%, respectively. A few species, such as Yellow-rumped Warblers (Dendroica coronata), exhibited these levels of response at lower tree retention or were not predicted to decrease by 75% in harvested stands. Five of the 6 species that were positively affected by harvesting showed at least a 50% increase in abundance at nearly all levels of tree retention, although other early successional bird species did not appear to benefit from the relatively small openings created by uniform partial harvesting. Three of 20 species exhibited stronger responses to harvesting at a given level of tree retention in boreal and northern mixed forests of North America than other regions of the continent, but, with these exceptions, lack of variation among forest regions supported the broad-scale generality of species' responses to harvesting. The species response models we developed represent useful tools for evaluating stand-level impacts of partial harvesting on birds within an adaptive management framework. Uniform partial harvesting at light and, to a lesser degree, moderate intensities may be effective approaches to managing habitat for late successional bird species as part of broader ecosystem-based forest management. PMID:17883488

Vanderwel, Mark C; Malcolm, Jay R; Mills, Stephen C

2007-10-01

248

A risk-informed approach to safety margins analysis  

SciTech Connect

The Risk Informed Safety Margins Characterization (RISMC) Pathway is a systematic approach developed to characterize and quantify safety margins of nuclear power plant structures, systems and components. The model has been tested on the Advanced Test Reactor (ATR) at Idaho National Lab.

Curtis Smith; Diego Mandelli

2013-07-01

249

Reliability Analysis of Safety-Related Communication Architectures  

E-print Network

errors it is necessary to use a reliable message transmission service (e.g. ARQ, Automatic Repeat Request by an operator. Therefore a safe communication reduces the fault tolerance against arbitrary transmission errors) before the safety check is executed. A reliable transmission service can be included in the safety layer

Peleska, Jan - Fachbereich 3

250

A social network analysis on safety culture and worker's behaviour  

Microsoft Academic Search

In this paper social network approach will be used to analyze safety culture and worker's behaviour in manufacturing industry. For this purpose we assume that each characteristic of safety culture, as well as worker's behaviour, is a member of social group and the relationship among them represents social relationship. With this point of view, those relationships can be quantified by

Shamshuritawati Sharif; Maman A. Djauhari; Hariza Djauhari

2012-01-01

251

Soft Mathematical Aggregation in Safety Assessment and Decision Analysis  

SciTech Connect

This paper improves on some of the limitations of conventional safety assessment and decision analysis methods. It develops a top-down mathematical method for expressing imprecise individual metrics as possibilistic or fuzzy numbers and shows how they may be combined (aggregated) into an overall metric, also portraying the inherent uncertainty. Both positively contributing and negatively contributing factors are included. Metrics are weighted according to significance of the attribute and evaluated as to contribution toward the attribute. Aggregation is performed using exponential combination of the metrics, since the accumulating effect of such factors responds less and less to additional factors. This is termed soft mathematical aggregation. Dependence among the contributing factors is accounted for by incorporating subjective metrics on overlap of the factors and by correspondingly reducing the overall contribution of these combinations to the overall aggregation. Decisions corresponding to the meaningfulness of the results are facilitated in several ways. First, the results are compared to a soft threshold provided by a sigmoid function. Second, information is provided on input ''Importance'' and ''Sensitivity,'' in order to know where to place emphasis on controls that may be necessary. Third, trends in inputs and outputs are tracked in order to add important information to the decision process. The methodology has been implemented in software.

Cooper, J. Arlin

1999-06-10

252

Fast Flux Test Facility final safety analysis report. Amendment 72  

SciTech Connect

This document provides the Final Safety Analysis Report (FSAR) Amendment 72 for incorporation into the Fast Flux Test Facility (FFTF) FSAR set. This amendment change incorporates Engineering Change Notices issued subsequent to Amendment 71 and approved for incorporation before June 24, 1992. These include changes in: Chapter 2, Site Characteristics; Chapter 3, Design Criteria Structures, Equipment, and Systems; Chapter 5B, Reactor Coolant System; Chapter 7, Instrumentation and Control Systems; Chapter 8, Electrical Systems - The description of the Class 1E, 125 Vdc systems is updated for the higher capacity of the newly installed, replacement batteries; Chapter 9, Auxiliary Systems - The description of the inert cell NASA systems is corrected to list the correct number of spare sample points; Chapter 11, Reactor Refueling System; Chapter 12, Radiation Protection and Waste Management; Chapter 13, Conduct of Operations; Chapter 16, Quality Assurance; Chapter 17, Technical Specifications; Chapter 19, FFTF Fire Specifications for Fire Detection, Alarm, and Protection Systems; Chapter 20, FFTF Criticality Specifications; and Appendix B, Primary Piping Integrity Evaluation.

Gantt, D.A.

1992-08-01

253

Partial wave analysis of the reaction gamma p -> p omega$ and the search for nucleon resonances  

SciTech Connect

An event-based partial wave analysis (PWA) of the reaction gamma p -> p omega has been performed on a high-statistics dataset obtained using the CLAS at Jefferson Lab for center-of-mass energies from threshold up to 2.4 GeV. This analysis benefits from access to the world's first high precision spin density matrix element measurements, available to the event-based PWA through the decay distribution of omega-> pi+ pi - pi0. The data confirm the dominance of the t-channel pi0 exchange amplitude in the forward direction. The dominant resonance contributions are consistent with the previously identified states F[15](1680) and D[13](1700) near threshold, as well as the G[17](2190) at higher energies. Suggestive evidence for the presence of a J(P)=5/2(+) state around 2 GeV, a "missing" state, has also been found. Evidence for other states is inconclusive.

M. Williams, D. Applegate, M. Bellis, C.A. Meyer

2009-12-01

254

Partial wave analysis of the reaction ?p?p? and the search for nucleon resonances  

NASA Astrophysics Data System (ADS)

An event-based partial wave analysis (PWA) of the reaction ?p?p? has been performed on a high-statistics dataset obtained using the CLAS at Jefferson Lab for center-of-mass energies from threshold up to 2.4 GeV. This analysis benefits from access to the world’s first high-precision spin-density matrix element measurements, available to the event-based PWA through the decay distribution of ???+?-?0. The data confirm the dominance of the t-channel ?0 exchange amplitude in the forward direction. The dominant resonance contributions are consistent with the previously identified states F15(1680) and D13(1700) near threshold, as well as the G17(2190) at higher energies. Suggestive evidence for the presence of a JP=5/2+ state around 2 GeV, a “missing” state, has also been found. Evidence for other states is inconclusive.

Williams, M.; Applegate, D.; Bellis, M.; Meyer, C. A.; Adhikari, K. P.; Anghinolfi, M.; Baghdasaryan, H.; Ball, J.; Battaglieri, M.; Bedlinskiy, I.; Berman, B. L.; Biselli, A. S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Careccia, S. L.; Carman, D. S.; Cole, P. L.; Collins, P.; Crede, V.; D'Angelo, A.; Daniel, A.; de Vita, R.; de Sanctis, E.; Deur, A.; Dey, B.; Dhamija, S.; Dickson, R.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dugger, M.; Dupre, R.; Alaoui, A. El; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fradi, A.; Gabrielyan, M. Y.; Garçon, M.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Hassall, N.; Hicks, K.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jawalkar, S. S.; Jo, H. S.; Johnstone, J. R.; Joo, K.; Keller, D.; Khandaker, M.; Khetarpal, P.; Kim, W.; Klein, A.; Klein, F. J.; Krahn, Z.; Kubarovsky, V.; Kuleshov, S. V.; Kuznetsov, V.; Livingston, K.; Lu, H. Y.; Mayer, M.; McAndrew, J.; McCracken, M. E.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Moreno, B.; Moriya, K.; Morrison, B.; Munevar, E.; Nadel-Turonski, P.; Nepali, C. S.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niroula, M. R.; Niyazov, R. A.; Osipenko, M.; Ostrovidov, A. I.; Paris, M.; Park, K.; Park, S.; Pasyuk, E.; Pereira, S. Anefalos; Perrin, Y.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Protopopescu, D.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salamanca, J.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seraydaryan, H.; Sharabian, Y. G.; Smith, E. S.; Sober, D. I.; Sokhan, D.; Stepanyan, S. S.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tedeschi, D. J.; Tkachenko, S.; Ungaro, M.; Vineyard, M. F.; Voutier, E.; Watts, D. P.; Weygand, D. P.; Wood, M. H.; Zhang, J.; Zhao, B.

2009-12-01

255

Safety culture evaluation and asset root cause analysis  

SciTech Connect

This paper examines the role of organizational and management factors in nuclear power plant safety through the use of operating experiences. The ASSET (Assessment of Safety Significant Events Team) reports of thirteen plants (total thirty events) have been analyzed in term of twenty organizational dimensions (factors) identified by Brookhaven National Laboratory and Pennsylvania State University. For three plants detailed results are reported in this paper. The results of thirteen plants are summarized in the form of a table. The study tends to confirm that organizational and management factors play an important role in plant safety. The twenty organizational dimensions and their definitions, in general, were adequate in this study. Formalization, Safety Culture, Technical Knowledge, Training, Roles-Responsibilities and Problem Identification appear to be key organizational factors which influence the safety of nuclear power plants studied.

Okrent, D.; Xiong, Y.

1995-12-31

256

Preliminary safety analysis for the Chinese ITER Dual Functional Lithium-Lead Test Blanket Module  

NASA Astrophysics Data System (ADS)

Safety analysis is part of the ITER Test Blanket Module (TBM) design process ensuring that the TBM does not adversely affect the safety of ITER. To get the licence for TBM as a whole with ITER, relevant safety analysis is required for each TBM system proposed by each party. The safety analysis for the Chinese Dual Functional Lithium-Lead Test Blanket Module (DFLL-TBM) has been performed based on the latest DFLL-TBM design. In this paper, the following safety considerations, such as source terms, operational releases, accident sequence analyses and waste assessment, were analysed. Both the deterministic approach and the complementary systematic approach starting with failure mode and effects analysis studies were adopted in the accidental analysis. The preliminary results showed that the DFLL-TBM system at normal operating conditions and under accident scenarios did not add additional safety hazards to the ITER machine and could meet the ITER safety requirements and additional safety requirements for the TBM system.

Chen, Hongli; Bai, Yunqing; Hu, Liqin; Chen, Mingliang; Song, Yong; Zeng, Qin; Liu, Songlin

2009-07-01

257

Heart rate changes in partial seizures: analysis of influencing factors among refractory patients  

PubMed Central

Background We analyzed the frequency of heart rate (HR) changes related to seizures, and we sought to identify the influencing factors of these changes during partial seizures, to summarize the regularity of the HR changes and gain some insight into the mechanisms involved in the neuronal regulation of cardiovascular function. To date, detailed information on influencing factors of HR changes related to seizures by multiple linear regression analysis remains scarce. Methods Using video-electroencephalograph (EEG)-electrocardiograph (ECG) recordings, we retrospectively assessed the changes in the HR of 81 patients during a total of 181 seizures, including 27 simple partial seizures (SPS), 110 complex partial seizures (CPS) and 44 complex partial seizures secondarily generalized (CPS-G). The epileptogenic focus and the seizure type, age, gender, and sleep/wakefulness state of each patient were evaluated during and after the seizure onset. The HR changes were evaluated in the stage of epilepsy as time varies. Results Of the 181 seizures from 81 patients with ictal ECGs, 152 seizures (83.98%) from 74 patients were accompanied by ictal tachycardia (IT). And only 1 patient was accompanied by ictal bradycardia (IB). A patient has both IT and IB. We observed that HR difference was independently correlated with side, type and sleep/wakefulness state. In this analysis, the HR changes were related to the side, gender, seizure type, and sleep/wakefulness state. Right focus, male, sleep, and CPS-G showed more significant increases than that were observed in left, female, wakefulness, SPS and CPS. HR increases rapidly within 10 seconds before seizure onset and ictus, and typically slows to normal with seizure offset. Conclusion CPS-G, sleep and right focus led to higher ictal HR. The HR in the stage of epilepsy has regularly been observed to change to become time-varying. The risk factors of ictal HR need to be controlled along with sleep, CPS-G and right focus. Our study first explains that the HR in seizures has a regular evolution varying with time. Our study might help to further clarify the basic mechanisms of interactions between heart and brain, making seizure detection and closed-loop systems a possible therapeutic alternative in refractory patients. PMID:24950859

2014-01-01

258

Analysis of pumping tests: Significance of well diameter, partial penetration, and noise  

USGS Publications Warehouse

The nonlinear least squares (NLS) method was applied to pumping and recovery aquifer test data in confined and unconfined aquifers with finite diameter and partially penetrating pumping wells, and with partially penetrating piezometers or observation wells. It was demonstrated that noiseless and moderately noisy drawdown data from observation points located less than two saturated thicknesses of the aquifer from the pumping well produced an exact or acceptable set of parameters when the diameter of the pumping well was included in the analysis. The accuracy of the estimated parameters, particularly that of specific storage, decreased with increases in the noise level in the observed drawdown data. With consideration of the well radii, the noiseless drawdown data from the pumping well in an unconfined aquifer produced good estimates of horizontal and vertical hydraulic conductivities and specific yield, but the estimated specific storage was unacceptable. When noisy data from the pumping well were used, an acceptable set of parameters was not obtained. Further experiments with noisy drawdown data in an unconfined aquifer revealed that when the well diameter was included in the analysis, hydraulic conductivity, specific yield and vertical hydraulic conductivity may be estimated rather effectively from piezometers located over a range of distances from the pumping well. Estimation of specific storage became less reliable for piezemeters located at distances greater than the initial saturated thickness of the aquifer. Application of the NLS to field pumping and recovery data from a confined aquifer showed that the estimated parameters from the two tests were in good agreement only when the well diameter was included in the analysis. Without consideration of well radii, the estimated values of hydraulic conductivity from the pumping and recovery tests were off by a factor of four.The nonlinear least squares method was applied to pumping and recovery aquifer test data in confined and unconfined aquifers with finite diameter and partially penetrating piezometers and observation wells. Noiseless and moderately noisy drawdown data from observation points located less than two saturated thicknesses of the aquifer from the pumping well produced a set of parameters that agrees very well with piezometer test data when the diameter of the pumping well was included in the analysis. The accuracy of the estimated parameters decreased with increasing noise level.

Heidari, M.; Ghiassi, K.; Mehnert, E.

1999-01-01

259

Reliability Modeling Methodology for Independent Approaches on Parallel Runways Safety Analysis  

NASA Technical Reports Server (NTRS)

This document is an adjunct to the final report An Integrated Safety Analysis Methodology for Emerging Air Transport Technologies. That report presents the results of our analysis of the problem of simultaneous but independent, approaches of two aircraft on parallel runways (independent approaches on parallel runways, or IAPR). This introductory chapter presents a brief overview and perspective of approaches and methodologies for performing safety analyses for complex systems. Ensuing chapter provide the technical details that underlie the approach that we have taken in performing the safety analysis for the IAPR concept.

Babcock, P.; Schor, A.; Rosch, G.

1998-01-01

260

Robotic versus Open Partial Nephrectomy: A Systematic Review and Meta-Analysis  

PubMed Central

Objectives To critically review the currently available evidence of studies comparing robotic partial nephrectomy (RPN) and open partial nephrectomy (OPN). Materials and Methods A comprehensive review of the literature from Pubmed, Web of Science and Scopus was performed in October 2013. All relevant studies comparing RPN with OPN were included for further screening. A cumulative meta-analysis of all comparative studies was performed and publication bias was assessed by a funnel plot. Results Eight studies were included for the analysis, including a total of 3418 patients (757 patients in the robotic group and 2661 patients in the open group). Although RPN procedures had a longer operative time (weighted mean difference [WMD]: 40.89; 95% confidence interval [CI], 14.39–67.40; p?=?0.002), patients in this group benefited from a lower perioperative complication rate (19.3% for RPN and 29.5% for OPN; odds ratio [OR]: 0.53; 95%CI, 0.42–0.67; p<0.00001), shorter hospital stay (WMD: ?2.78; 95%CI, ?3.36 to ?1.92; p<0.00001), less estimated blood loss(WMD: ?106.83; 95%CI, ?176.4 to ?37.27; p?=?0.003). Transfusions, conversion to radical nephrectomy, ischemia time and estimated GFR change, margin status, and overall cost were comparable between the two techniques. The main limitation of the present meta-analysis is the non-randomization of all included studies. Conclusions RPN appears to be an efficient alternative to OPN with the advantages of a lower rate of perioperative complications, shorter length of hospital stay and less blood loss. Nevertheless, high quality prospective randomized studies with longer follow-up period are needed to confirm these findings. PMID:24740259

Cai, Chen; Ye, Huamao; Lv, Chen; Yang, Qing; Sheng, Jing; Song, Shangqing; Qu, Le; Xiao, Liang; Sun, Yinghao; Wang, Linhui

2014-01-01

261

Cultural backgrounds of employees' safety behaviors: Coding and cluster analysis on participant observation  

Microsoft Academic Search

Safety culture is a social control power in hazardous industrial systems. This study aims to explore the characteristics of safety culture in China. The 128 behavior incidents of employees' routine work were gained through 103 days' participant observation in a state owned petrochemical plant. Cluster analysis was conducted on the selected 109 incidents, and finally assembling them into 4 categories

Qi Zhang; Guangtao Yu; Erping Wang

2009-01-01

262

A statistical analysis of the impact of advertising signs on road safety  

Microsoft Academic Search

This research aims to investigate the impact of advertising signs on road safety. An exhaustive review of international literature was carried out on the effect of advertising signs on driver behaviour and safety. Moreover, a before-and-after statistical analysis with control groups was applied on several road sites with different characteristics in the Athens metropolitan area, in Greece, in order to

George Yannis; Eleonora Papadimitriou; Panagiotis Papantoniou; Chrisoula Voulgari

2012-01-01

263

Aircraft Autolander Safety Analysis Through Optimal Control-Based Reach Set Computation  

E-print Network

Aircraft Autolander Safety Analysis Through Optimal Control-Based Reach Set Computation Alexandre M for thenumerical computation ofreachable sets for hybrid systems is presented and appliedto thedesign and safety a maximal controlled invariant set and a set-valued control law guaranteed to keep the aircraft within

264

Method for carrier aircraft task flow safety analysis based on TPN  

Microsoft Academic Search

With tight timing, sequencing and compact, the time error of any task flow activities of carrier aircrafts may result flow fracturing, leading to unsafe task. Currently, the research in the carrier aircraft safety is mainly focused on the quality of its flight dynamics modeling and simulation, while for carrier aircraft task flow analysis, its improvement, and safety induced by the

Zhaoguang Peng; Tingdi Zhao; Jin Tian

2011-01-01

265

A System Theoretic Safety Analysis of Friendly Fire Prevention in Ground Based Missile Systems  

E-print Network

A System Theoretic Safety Analysis of Friendly Fire Prevention in Ground Based Missile Systems to guide my career and will enable me to more effectively deal with the safety issues that arise in complex Tornado aircraft and a US Patriot Missile battery. This causation model analyzes system constraints

Leveson, Nancy

266

In-space propellant systems safety. Volume 3: System safety analysis  

NASA Technical Reports Server (NTRS)

The primary objective was to examine from a system safety viewpoint in-space propellant logistic elements and operations to define the potential hazards and to recommend means to reduce, eliminate or control them. A secondary objective was to conduct trade studies of specific systems or operations to determine the safest of alternate approaches.

1972-01-01

267

SAID Partial Wave Analyses from CNS DAC (Center for Nuclear Studies Data Analysis Center)  

DOE Data Explorer

George Washington University (GW) has one of the largest university-based nuclear-physics groups in the nation. Many of the current and future projects are geared to Thomas Jefferson National Accelerator Facility (JLab) at Newport News, VA. JLab is the world's premier electron accelerator for nuclear physics, and GW is one of the charter members of the governing body of JLab, the Southeastern Universities Research Association (SURA). The George Washington Data Analysis Center (DAC) was created in 1998 by an agreement among the Department of Energy, Jefferson Lab, and the GW Center for Nuclear Studies.The activities of the DAC fall into four distinct categories: 1) Performing partial-wave analyses of fundamental two- and three-body reactions; 2) Maintenance of databases associated with these reactions; 3) Development of software to disseminate DAC results (as well as the results of competing model-independent analyses and potential approaches); and 4) Phenomenological and theoretical investigations which bridge the gap between theory and experiment; in particular, the extraction of N* and D * hadronic and electromagnetic couplings. Partial Wave Analyses (and the associated databases) available at GW are: Pion-Nucleon, Kaon-Nucleon, Nucleon-Nucleon, Pion Photoproduction, Pion Electroproduction, Kaon Photoproduction, Eta Photoproduction, Eta-Prime Photoproduction, Pion-Deuteron (elastic), and Pion-Deuteron to Proton+Proton. [Taken from http://www.gwu.edu/~ndl/dac.htm">http://www.gwu.edu/~ndl/dac.htm

268

Need for a new pion nucleon partial wave analysis in the N*(1440) resonance region  

NASA Astrophysics Data System (ADS)

Existing determinations of the masses, widths and decay modes of low-lying excited states of the nucleon, as compiled in the Review of Particle Physics, are determined from energy-independent partial wave analyses of pion-nucleon scattering data. For the N*(1440) and most other resonances under 2 GeV, the analyses cited are the Karlsruhe-Helsinki, Carnegie Mellon-Berkeley and Kent State analyses, the latter of which used the elastic amplitudes from the other two. The data included in these analyses were published before 1980. Other analyses, notably the recent ones from George Washington University and the Pittsburgh-Argonne group, are "not used for averages, fits, limits, etc." Complete sets of measurements (differential cross sections, analyzing powers and spin rotation parameters) have been measured in the N*(1440) resonance region since 1980, culminating in the Crystal Ball program at BNL to measure all-neutral final states (charge exchange, multiple ?0 final states, ? production near threshold and inverse photoproduction). An overview of these data is presented and the case is made for a revitalized partial wave analysis effort

Sadler, M. E.

2005-01-01

269

Analysis of Multiple Partially Ordered Responses to Belief Items with Don't Know Option.  

PubMed

Understanding beliefs, values, and preferences of patients is a tenet of contemporary health sciences. This application was motivated by the analysis of multiple partially ordered set (poset) responses from an inventory on layman beliefs about diabetes. The partially ordered set arises because of two features in the data-first, the response options contain a Don't Know (DK) option, and second, there were two consecutive occasions of measurement. As predicted by the common sense model of illness, beliefs about diabetes were not necessarily stable across the two measurement occasions. Instead of analyzing the two occasions separately, we studied the joint responses across the occasions as a poset response. Few analytic methods exist for data structures other than ordered or nominal categories. Poset responses are routinely collapsed and then analyzed as either rank ordered or nominal data, leading to the loss of nuanced information that might be present within poset categories. In this paper we developed a general class of item response models for analyzing the poset data collected from the Common Sense Model of Diabetes Inventory. The inferential object of interest is the latent trait that indicates congruence of belief with the biomedical model. To apply an item response model to the poset diabetes inventory, we proved that a simple coding algorithm circumvents the requirement of writing new codes such that standard IRT software could be directly used for the purpose of item estimation and individual scoring. Simulation experiments were used to examine parameter recovery for the proposed poset model. PMID:25479822

Ip, Edward H; Chen, Shyh-Huei; Quandt, Sara A

2014-12-01

270

Factors Analysis on Safety of Indoor Air Quality  

E-print Network

Influence factors on safety of indoor air quality (IAQ) were analyzed in this paper. Some regeneration compositions resulting from potential indoor chemical reactions may be more harmful to habitants. A few building flaws may be key factors...

Luo, Q.; Liu, Z.; Xiong, J.

2006-01-01

271

Aspects of environmental and safety analysis of fusion reactors  

E-print Network

This report summarizes the progress made between October 1976 and September 1977 in studies of some environmental and safety considerations in fusion reactor plants. A methodology to assess the admissible occurrence rate ...

Kazimi, Mujid S.

1977-01-01

272

Documentation of Hanford Site independent review of the Hanford Waste Vitrification Plant Preliminary Safety Analysis Report  

SciTech Connect

The requirements for Westinghouse Hanford independent review of the Preliminary Safety Analysis Report (PSAR) are contained in Section 1.0, Subsection 4.3 of WCH-CM-4-46. Specifically, this manual requires the following: (1) Formal functional reviews of the HWVP PSAR by the future operating organization (HWVP Operations), and the independent review organizations (HWVP and Environmental Safety Assurance, Environmental Assurance, and Quality Assurance); and (2) Review and approval of the HWVP PSAR by the Tank Waste Disposal (TWD) Subcouncil of the Safety and Environmental Advisory Council (SEAC), which provides independent advice to the Westinghouse Hanford President and executives on matters of safety and environmental protection. 7 refs.

Herborn, D.I.

1991-10-01

273

Reliability Modeling and Analysis of Safety-Critical Manufacture System  

Microsoft Academic Search

There are working, fail-safe and fail-dangerous states in safety-critical manufacture systems. This paper presents three typical safety-critical manufacture system architecture models: series, parallel and series-parallel system, whose components lifetime distributions are general forms. Also the reliability related indices, such as the probabilities that the system in these states and the mean times for the system fail-safe and fail-dangerous, are derived

Qing Sun; Lirong Cui; Gong Chen; Rong Pan

2009-01-01

274

Markov Modeling with Soft Aggregation for Safety and Decision Analysis  

SciTech Connect

The methodology in this report improves on some of the limitations of many conventional safety assessment and decision analysis methods. A top-down mathematical approach is developed for decomposing systems and for expressing imprecise individual metrics as possibilistic or fuzzy numbers. A ''Markov-like'' model is developed that facilitates combining (aggregating) inputs into overall metrics and decision aids, also portraying the inherent uncertainty. A major goal of Markov modeling is to help convey the top-down system perspective. One of the constituent methodologies allows metrics to be weighted according to significance of the attribute and aggregated nonlinearly as to contribution. This aggregation is performed using exponential combination of the metrics, since the accumulating effect of such factors responds less and less to additional factors. This is termed ''soft'' mathematical aggregation. Dependence among the contributing factors is accounted for by incorporating subjective metrics on ''overlap'' of the factors as well as by correspondingly reducing the overall contribution of these combinations to the overall aggregation. Decisions corresponding to the meaningfulness of the results are facilitated in several ways. First, the results are compared to a soft threshold provided by a sigmoid function. Second, information is provided on input ''Importance'' and ''Sensitivity,'' in order to know where to place emphasis on considering new controls that may be necessary. Third, trends in inputs and outputs are tracked in order to obtain significant information% including cyclic information for the decision process. A practical example from the air transportation industry is used to demonstrate application of the methodology. Illustrations are given for developing a structure (along with recommended inputs and weights) for air transportation oversight at three different levels, for developing and using cycle information, for developing Importance and Sensitivity measures for soil aggregation, for developing dependence methodology, for constructing early alert logic, for tracking trends, for relating the Markov model to other (e.g., Reason) models, for developing and demonstrating rudimentary laptop software, and for developing an input/output display methodology.

COOPER,J. ARLIN

1999-09-01

275

Does partial root-zone drying improve irrigation water productivity in the field? A meta-analysis  

Microsoft Academic Search

Partial root-zone drying improves irrigation water productivity (IWP, yield per unit applied irrigation water) with respect\\u000a to controls receiving substantially more water, but similar gains are often achieved with conventional deficit irrigation.\\u000a This paper presents a meta-analysis of IWP for a broad range of horticultural crops and environments. Two comparisons were\\u000a preformed: (a) crops managed with either partial root-zone drying

V. O. Sadras

2009-01-01

276

New Methods and Tools to Perform Safety Analysis within RISMC  

SciTech Connect

The Risk Informed Safety Margins Characterization (RISMC) Pathway uses a systematic approach developed to characterize and quantify safety margins of nuclear power plant structures, systems and components. What differentiates the RISMC approach from traditional probabilistic risk assessment (PRA) is the concept of safety margin. In PRA, a safety metric such as core damage frequency (CDF) is generally estimated using static fault-tree and event-tree models. However, it is not possible to estimate how close we are to physical safety limits (say peak clad temperature) for most accident sequences described in the PRA. In the RISMC approach, what we want to understand is not just the frequency of an event like core damage, but how close we are (or not) to this event and how we might increase our safety margin through margin management strategies in a Dynamic PRA (DPRA) fashion. This paper gives an overview of methods that are currently under development at the Idaho National Laboratory (INL) with the scope of advance the current state of the art of dynamic PRA.

Diego Mandelli; Curtis Smith; Cristian Rabiti; Andrea Alfonsi; Robert Kinoshita; Joshua Cogliati

2013-11-01

277

Note: Multivariate system spectroscopic model using Lorentz oscillators and partial least squares regression analysis  

NASA Astrophysics Data System (ADS)

Multivariate system spectroscopic model plays important role in understanding chemometrics of ensemble under study. Here in this manuscript we discuss various approaches of modeling of spectroscopic system and demonstrate how Lorentz oscillator can be used to model any general spectroscopic system. Chemometric studies require customized templates design for the corresponding variants participating in ensemble, which generates the characteristic matrix of the ensemble under study. The typical biological system that resembles human blood tissue consisting of five major constituents i.e., alanine, urea, lactate, glucose, ascorbate; has been tested on the model. The model was validated using three approaches, namely, root mean square error (RMSE) analysis in the range of ±5% confidence interval, clerk gird error plot, and RMSE versus percent noise level study. Also the model was tested across various template sizes (consisting of samples ranging from 10 up to 1000) to ascertain the validity of partial least squares regression. The model has potential in understanding the chemometrics of proteomics pathways.

Gad, R. S.; Parab, J. S.; Naik, G. M.

2010-11-01

278

Fourier transform infrared spectroscopy quantitative analysis of SF6 partial discharge decomposition components  

NASA Astrophysics Data System (ADS)

Gas-insulated switchgear (GIS) internal SF6 gas produces specific decomposition components under partial discharge (PD). By detecting these characteristic decomposition components, such information as the type and level of GIS internal insulation deterioration can be obtained effectively, and the status of GIS internal insulation can be evaluated. SF6 was selected as the background gas for Fourier transform infrared spectroscopy (FTIR) detection in this study. SOF2, SO2F2, SO2, and CO were selected as the characteristic decomposition components for system analysis. The standard infrared absorption spectroscopy of the four characteristic components was measured, the optimal absorption peaks were recorded and the corresponding absorption coefficient was calculated. Quantitative detection experiments on the four characteristic components were conducted. The volume fraction variation trend of four characteristic components at different PD time were analyzed. And under five different PD quantity, the quantitative relationships among gas production rate, PD time, and PD quantity were studied.

Zhang, Xiaoxing; Liu, Heng; Ren, Jiangbo; Li, Jian; Li, Xin

2015-02-01

279

Thermodynamic analysis and conceptual design for partial coal gasification air preheating coal-fired combined cycle  

NASA Astrophysics Data System (ADS)

The partial coal gasification air pre-heating coal-fired combined cycle (PGACC) is a cleaning coal power system, which integrates the coal gasification technology, circulating fluidized bed technology, and combined cycle technology. It has high efficiency and simple construction, and is a new selection of the cleaning coal power systems. A thermodynamic analysis of the PGACC is carried out. The effects of coal gasifying rate, pre-heating air temperature, and coal gas temperature on the performances of the power system are studied. In order to repower the power plant rated 100 MW by using the PGACC, a conceptual design is suggested. The computational results show that the PGACC is feasible for modernizing the old steam power plants and building the new cleaning power plants.

Xu, Yue; Wu, Yining; Deng, Shimin; Wei, Shirang

2004-02-01

280

Partial wave analysis of J/{psi}{yields}pp{pi}{sup 0}  

SciTech Connect

Using a sample of 58 million J/{psi} events collected with the BESII detector at the BEPC, more than 100 000 J/{psi}{yields}pp{pi}{sup 0} events are selected, and a detailed partial wave analysis is performed. The branching fraction is determined to be Br(J/{psi}{yields}pp{pi}{sup 0})=(1.33{+-}0.02{+-}0.11)x10{sup -3}. A long-sought missing N*, first observed in J/{psi}{yields}pn{pi}{sup -}, is observed in this decay too, with mass and width of 2040{sub -4}{sup +3}{+-}25 MeV/c{sup 2} and 230{sub -8}{sup +8}{+-}52 MeV/c{sup 2}, respectively. Its spin-parity favors (3/2){sup +}. The masses, widths, and spin parities of other N* states are obtained as well.

Ablikim, M.; Bai, J. Z.; Bai, Y.; Cai, X.; Chen, H. S.; Chen, H. X.; Chen, J. C.; Chen, Jin; Chen, Y. B.; Chu, Y. P.; Deng, Z. Y.; Du, S. X.; Fang, J.; Fu, C. D.; Gao, C. S.; Gu, S. D.; Guo, Y. N.; He, K. L.; Heng, Y. K.; Hu, H. M. [Institute of High Energy Physics, Beijing 100049 (China)] (and others)

2009-09-01

281

Fourier transform infrared spectroscopy quantitative analysis of SF6 partial discharge decomposition components.  

PubMed

Gas-insulated switchgear (GIS) internal SF6 gas produces specific decomposition components under partial discharge (PD). By detecting these characteristic decomposition components, such information as the type and level of GIS internal insulation deterioration can be obtained effectively, and the status of GIS internal insulation can be evaluated. SF6 was selected as the background gas for Fourier transform infrared spectroscopy (FTIR) detection in this study. SOF2, SO2F2, SO2, and CO were selected as the characteristic decomposition components for system analysis. The standard infrared absorption spectroscopy of the four characteristic components was measured, the optimal absorption peaks were recorded and the corresponding absorption coefficient was calculated. Quantitative detection experiments on the four characteristic components were conducted. The volume fraction variation trend of four characteristic components at different PD time were analyzed. And under five different PD quantity, the quantitative relationships among gas production rate, PD time, and PD quantity were studied. PMID:25459612

Zhang, Xiaoxing; Liu, Heng; Ren, Jiangbo; Li, Jian; Li, Xin

2015-02-01

282

Genome-Wide Single Nucleotide Polymorphism Analysis Reveals Frequent Partial Uniparental Disomy Due to Somatic Recombination in Acute Myeloid Leukemias  

Microsoft Academic Search

Genome-wide analysis of single nucleotide polymorphisms in 64 acute myeloid leukemias has revealed that f20% exhibited large regions of homozygosity that could not be accounted for by visible chromosomal abnormalities in the karyotype. Further analysis confirmed that these patterns were due to partial uniparental disomy (UPD). Remission bone marrow was available from five patients showing UPD in their leukemias, and

Manoj Raghavan; Debra M. Lillington; Spyros Skoulakis; Silvana Debernardi; Tracy Chaplin; Nicola J. Foot; T. Andrew Lister; Bryan D. Young

2005-01-01

283

Safety Analysis Report: X17B2 beamline Synchrotron Medical Research Facility  

SciTech Connect

This report contains a safety analysis for the X17B2 beamline synchrotron medical research facility. Health hazards, risk assessment and building systems are discussed. Reference is made to transvenous coronary angiography. (LSP)

Gmuer, N.F.; Thomlinson, W.

1990-02-01

284

Malliavin calculus and applications to sensitivity analysis of stochastic partial differential equations  

NASA Astrophysics Data System (ADS)

In this thesis, we apply Malliavin calculus to the sensitivity analysis of a stochastic partial differential equation of the Schrodinger type. The equation appears as the major building block in the analysis of the focusing properties of time-reversed waves in a random medium in the asymptotic regime where the parabolic approximation is valid. We consider the sensitivities of the solutions with respect to all sorts of parameters. Because of the imperfectness of the time reversal mirror, the time-reversed signal is an integral of a cut-off function. This makes Monte Carlo numerical schemes ineffecient for sensitivity analysis. Here Malliavin calculus comes to the rescue since it emerged out of the stochastic calculus of variations. With its "Integration by Parts" formula, we avoid computing the derivative of the cut-off function. Instead, we obtain close form formulae for the sensitivities in terms of Skorohod integrals with respect to an infinite dimensional Wiener process. We also construct finite dimensional approximation schemes for these integrals. These schemes are based on a sieve of Wiener chaos expansions mixed with Galerkin approximations in a natural Fourier basis. Numerical implementation is done in both 2-D and 3-D. To the best of our knowledge, the numerical computation of the stochastic Schrodinger equation's solution was only carried out in 2-D, and even in that case our numerical algorithm seems better than those we found in the literature.

Wang, Lixin

285

Long-term safety of perampanel and seizure outcomes in refractory partial-onset seizures and secondarily generalized seizures: Results from phase III extension study 307  

PubMed Central

Objective To evaluate safety, tolerability, seizure frequency, and regional variations in treatment responses with the AMPA antagonist, perampanel, in a large extension study during up to 3 years of treatment. Methods Patients ?12 years old with partial-onset seizures despite treatment with 1–3 antiepileptic drugs at baseline completed a perampanel phase III trial and entered extension study 307 (NCT00735397). Patients were titrated to 12 mg/day (or their individual maximum tolerated dose) during the blinded conversion period, followed by open-label maintenance. Exposure, safety (adverse events [AEs], vital signs, weight, electrocardiography [ECG], laboratory values) and seizure outcomes were analyzed; key measures were assessed by geographic regions. Results Among 1,216 patients, median exposure was 1.5 years (range 1 week to 3.3 years), with >300 patients treated for >2 years. Treatment retention was 58.5% at cutoff. AEs reported in ?10% of patients were dizziness, somnolence, headache, fatigue, irritability, and weight increase. Only dizziness and irritability caused discontinuation in >1% of patients (3.9% and 1.3%, respectively). The only serious AEs reported in >1% of patients were epilepsy-related (convulsion, 3.0%; status epilepticus, 1.1%). No clinically relevant changes in vital signs, ECG or laboratory parameters were seen. After titration/conversion, responder rate and median percentage change from baseline in seizure frequency were stable: 46% for both measures at 9 months (in 980 patients with ?9 months' exposure) and 58% and 60%, respectively, at 2 years (in the 337 patients with 2 years' exposure). Median percentage reduction in frequency of secondarily generalized (SG) seizures ranged from 77% at 9 months (N = 422) to 90% at 2 years (N = 141). Among the 694 patients with maintenance data ?1 year, 5.3% were seizure-free for the entire year. Significance No new safety signals emerged during up to 3 years of perampanel exposure in 39 countries. Seizure responses remained stable, with marked reductions, particularly in SG seizures. PMID:24867391

Krauss, Gregory L; Perucca, Emilio; Ben-Menachem, Elinor; Kwan, Patrick; Shih, Jerry J; Clément, Jean-François; Wang, Xuefeng; Bagul, Makarand; Gee, Michelle; Zhu, Jin; Squillacote, David

2014-01-01

286

Prospective Safety Analysis and the Complex Aviation System  

NASA Technical Reports Server (NTRS)

Fatal accident rates in commercial passenger aviation are at historic lows yet have plateaued and are not showing evidence of further safety advances. Modern aircraft accidents reflect both historic causal factors and new unexpected "Black Swan" events. The ever-increasing complexity of the aviation system, along with its associated technology and organizational relationships, provides fertile ground for fresh problems. It is important to take a proactive approach to aviation safety by working to identify novel causation mechanisms for future aviation accidents before they happen. Progress has been made in using of historic data to identify the telltale signals preceding aviation accidents and incidents, using the large repositories of discrete and continuous data on aircraft and air traffic control performance and information reported by front-line personnel. Nevertheless, the aviation community is increasingly embracing predictive approaches to aviation safety. The "prospective workshop" early assessment tool described in this paper represents an approach toward this prospective mindset-one that attempts to identify the future vectors of aviation and asks the question: "What haven't we considered in our current safety assessments?" New causation mechanisms threatening aviation safety will arise in the future because new (or revised) systems and procedures will have to be used under future contextual conditions that have not been properly anticipated. Many simulation models exist for demonstrating the safety cases of new operational concepts and technologies. However the results from such models can only be as valid as the accuracy and completeness of assumptions made about the future context in which the new operational concepts and/or technologies will be immersed. Of course that future has not happened yet. What is needed is a reasonably high-confidence description of the future operational context, capturing critical contextual characteristics that modulate both the likelihood of occurrence of hazards, and the likelihood that those hazards will lead to negative safety events. Heuristics extracted from scenarios, questionnaires, and observed trends from scanning the aviation horizon may be helpful in capturing those future changes in a way conducive to safety assessment. What is also needed is a checklist of potential sources of emerging risk that arise from organizational features that are frequently overlooked. The ultimate goal is to develop a pragmatic, workable method for using descriptions of the future aviation context, to generate valid predictions of safety risks.

Smith, Brian E.

2013-01-01

287

Static-stress analysis of dual-axis safety vessel  

NASA Astrophysics Data System (ADS)

An 8 ft diameter safety vessel, made of HSLA-100 steel, is evaluated to determine its ability to contain the quasi-static residual pressure from a high explosive (HE) blast. The safety vessel is designed for use with the Dual-Axis Radiographic Hydrotest (DARHT) facility being developed at Los Alamos National Laboratory. A smaller confinement vessel fits inside the safety vessel and contains the actual explosion, and the safety vessel functions as a second layer of containment in the unlikely case of a confinement vessel leak. The safety vessel is analyzed as a pressure vessel based on the ASME Boiler and Pressure Vessel Code, Section 8, Division 1, and the Welding Research Council Bulletin, WRC107. Combined stresses that result from internal pressure and external loads on nozzles are calculated and compared to the allowable stresses for HSLA-100 steel. Results confirm that the shell and nozzle components are adequately designed for a static pressure of 830 psi, plus the maximum expected external loads. Shell stresses at the 'shell to nozzle' interface, produced from external loads on the nozzles, were less than 700 psi. The maximum combined stress resulting from the internal pressure plus external loads was 17,384 psi, which is significantly less than the allowable stress of 42,375 psi for HSLA-100 steel.

Bultman, D. H.

1992-11-01

288

Macroergonomic analysis and design for improved safety and quality performance.  

PubMed

Macroergonomics, which emerged historically after sociotechnical systems theory, quality management, and ergonomics, is presented as the basis for a needed integrative methodology. A macroergonomics methodology was presented in some detail to demonstrate how aspects of microergonomics, total quality management (TQM), and sociotechnical systems (STS) can be triangulated in a common approach. In the context of this methodology, quality and safety were presented as 2 of several important performance criteria. To demonstrate aspects of the methodology, 2 case studies were summarized with safety and quality performance results where available. The first case manipulated both personnel and technical factors to achieve a "safety culture" at a nuclear site. The concept of safety culture is defined in INSAG-4 (International Atomic Energy Agency, 1991). as "that assembly of characteristics and attitudes in organizations and individuals which establishes that, as an overriding priority, nuclear plant safety issues receive the attention warranted by their significance." The second case described a tire manufacturing intervention to improve quality (as defined by Sink and Tuttle, 1989) through joint consideration of technical and social factors. It was suggested that macroergonomics can yield greater performance than can be achieved through ergonomic intervention alone. Whereas case studies help to make the case, more rigorous formative and summative research is needed to refine and validate the proposed methodology respectively. PMID:10602647

Kleiner, B M

1999-01-01

289

Multichannel Analysis of Surface Waves and Dam Safety  

NASA Astrophysics Data System (ADS)

Geophysical methodologies and particularly the Multichannel Analysis of Surface Waves (MASW) effectively proved their efficiency in the non-destructive testing of the dams, in the last decade, after many successful applications worldwide. The MASW method developed in the outset of this decade considerably improved the prospects and the validity of these geophysical applications. Since MASW and the other geophysical techniques do not require drilling they progressively increased their popularity significantly. The Multichannel Analysis of Surface Waves can be applied for the assessment of both earthen and concrete dams. Nevertheless, mostly cases of earthen dams can be found in the literature. The method can detect and map low shear wave velocity areas potentially associated with low cohesion zones due to differential settlement events in the core or increased seepage. The advantage of MASW is that it is not influenced by the water saturation of the interior of the dam contrary to other methods eg. p-wave tomography. Usually, a joint application of MASW with the p-wave techniques can be an optimal choice since the two methodologies can act complementary. An application of MASW on a three-dimensional structure, such as a dam, however, can actually be considered as a complicated problem since the effects of the lateral structural anomalies can strongly affect the results. For example, in an earthen dam the investigation of the core can be influenced by the presence of the shells. Therefore, the problem should be carefully examined by modeling all these the lateral anomalies with the aim to avoid a misinterpretation of the results. The effectiveness of MASW to the dam safety assessment is presented through two example applications, one at the Mornos Dam, an earthen dam responsible for the water supply of Athens, and a second one at the Marathon Dam which is a concrete dam also used for the water supply of Athens. In the case of Mornos Dam, MASW detected areas affected by the differential settlement of the dam and more specifically by the arching phenomenon in the core. Such phenomena can lead to hydraulic fracture in the core and therefore should be carefully encountered. In particular the method detected, in the central part of the core, a weak zone just below the crest and another one at depth of 45 below crest, at a place where the monitoring instruments of the dam had measured very low effective stresses. This zone follows the shape pattern of the riverbed and at the edges of the crest it is connected with two other thick tensile zones. The example from the application in the concrete dam at Marathon is focused on the interior of the dam. The data acquired there, in the tunnels, were of different character than the ones gathered on usual applications on soil environment mainly due to the high and broad frequency content and the high phase velocity values. The standard data acquisition procedure also required some modification for the triggering and recording. The analysis of the data showed that such an application could provide useful results for the testing of the concrete quality.

Karastathis, V. K.

2012-12-01

290

COLLECTION OF MICRO-LEVEL SAFETY AND EFFICIENCY INDICATORS WITH AUTOMATED VIDEO ANALYSIS  

E-print Network

1 COLLECTION OF MICRO-LEVEL SAFETY AND EFFICIENCY INDICATORS WITH AUTOMATED VIDEO ANALYSIS Ã?se-of service) of the local traffic system. Automated video analysis is suggested as a tool for collection describe the current state of the video analysis system developed at Lund University, Sweden

Lunds Universitet

291

Safety of railway control systems: A new Preliminary Risk Analysis approach  

E-print Network

Safety of railway control systems: A new Preliminary Risk Analysis approach Fateh GUENAB, Jean.P. 20529, F-60205, Compiègne - France Abstract Preliminary risk analysis (PRA) is a methodology used the frequency of the contributors or reduce the severity of the accident). The preliminary risk analysis

Paris-Sud XI, Université de

292

Sodium fast reactor gaps analysis of computer codes and models for accident analysis and reactor safety.  

SciTech Connect

This report summarizes the results of an expert-opinion elicitation activity designed to qualitatively assess the status and capabilities of currently available computer codes and models for accident analysis and reactor safety calculations of advanced sodium fast reactors, and identify important gaps. The twelve-member panel consisted of representatives from five U.S. National Laboratories (SNL, ANL, INL, ORNL, and BNL), the University of Wisconsin, the KAERI, the JAEA, and the CEA. The major portion of this elicitation activity occurred during a two-day meeting held on Aug. 10-11, 2010 at Argonne National Laboratory. There were two primary objectives of this work: (1) Identify computer codes currently available for SFR accident analysis and reactor safety calculations; and (2) Assess the status and capability of current US computer codes to adequately model the required accident scenarios and associated phenomena, and identify important gaps. During the review, panel members identified over 60 computer codes that are currently available in the international community to perform different aspects of SFR safety analysis for various event scenarios and accident categories. A brief description of each of these codes together with references (when available) is provided. An adaptation of the Predictive Capability Maturity Model (PCMM) for computational modeling and simulation is described for use in this work. The panel's assessment of the available US codes is presented in the form of nine tables, organized into groups of three for each of three risk categories considered: anticipated operational occurrences (AOOs), design basis accidents (DBA), and beyond design basis accidents (BDBA). A set of summary conclusions are drawn from the results obtained. At the highest level, the panel judged that current US code capabilities are adequate for licensing given reasonable margins, but expressed concern that US code development activities had stagnated and that the experienced user-base and the experimental validation base was decaying away quickly.

Carbajo, Juan (Oak Ridge National Laboratory, Oak Ridge, TN); Jeong, Hae-Yong (Korea Atomic Energy Research Institute, Daejeon, Korea); Wigeland, Roald (Idaho National Laboratory, Idaho Falls, ID); Corradini, Michael (University of Wisconsin, Madison, WI); Schmidt, Rodney Cannon; Thomas, Justin (Argonne National Laboratory, Argonne, IL); Wei, Tom (Argonne National Laboratory, Argonne, IL); Sofu, Tanju (Argonne National Laboratory, Argonne, IL); Ludewig, Hans (Brookhaven National Laboratory, Upton, NY); Tobita, Yoshiharu (Japan Atomic Energy Agency, Ibaraki-ken, Japan); Ohshima, Hiroyuki (Japan Atomic Energy Agency, Ibaraki-ken, Japan); Serre, Frederic (Centre d'%C3%94etudes nucl%C3%94eaires de Cadarache %3CU%2B2013%3E CEA, France)

2011-06-01

293

Analysis of factors influencing safety management for metro construction in China.  

PubMed

With the rapid development of urbanization in China, the number and size of metro construction projects are increasing quickly. At the same time, and increasing number of accidents in metro construction make it a disturbing focus of social attention. In order to improve safety management in metro construction, an investigation of the participants' perspectives on safety factors in China metro construction has been conducted to identify the key safety factors, and their ranking consistency among the main participants, including clients, consultants, designers, contractors and supervisors. The result of factor analysis indicates that there are five key factors which influence the safety of metro construction including safety attitude, construction site safety, government supervision, market restrictions and task unpredictability. In addition, ANOVA and Spearman rank correlation coefficients were performed to test the consistency of the means rating and the ranking of safety factors. The results indicated that the main participants have significant disagreement about the importance of safety factors on more than half of the items. Suggestions and recommendations on practical countermeasures to improve metro construction safety management in China are proposed. PMID:23932091

Yu, Q Z; Ding, L Y; Zhou, C; Luo, H B

2014-07-01

294

Comparison of a Traditional Probabilistic Risk Assessment Approach with Advanced Safety Analysis  

SciTech Connect

As part of the Light Water Sustainability Program (LWRS) [1], the purpose of the Risk Informed Safety Margin Characterization (RISMC) [2] Pathway research and development (R&D) is to support plant decisions for risk-informed margin management with the aim to improve economics, reliability, and sustain safety of current NPPs. In this paper, we describe the RISMC analysis process illustrating how mechanistic and probabilistic approaches are combined in order to estimate a safety margin. We use the scenario of a “station blackout” (SBO) wherein offsite power and onsite power is lost, thereby causing a challenge to plant safety systems. We describe the RISMC approach, illustrate the station blackout modeling, and contrast this with traditional risk analysis modeling for this type of accident scenario. We also describe our approach we are using to represent advanced flooding analysis.

Smith, Curtis L; Mandelli, Diego; Zhegang Ma

2014-11-01

295

Oak Ridge National Laboratory site data for safety-analysis report  

SciTech Connect

The Oak Ridge National Laboratory site data contained herein were compiled in support of the United States Department of Energy (USDOE) Oak Ridge Operations Office Order OR 5481.1. That order sets forth assignment of responsibilities for safety analysis and review responsibilities and provides guidance relative to the content and format of safety analysis reports. The information presented in this document is intended for use by reference in individual safety analysis reports where applicable to support accident analyses or the establishment of design bases of significance to safety, and it is applicable only to Oak Ridge National Laboratory facilities in Bethel and Melton Valleys. This information includes broad descriptions of the site characteristics, radioactive waste handling and monitoring practices, and the organization and operating policies at Oak Ridge National Laboratory. The historical background of the Laboratory is discussed briefly and the overall physical situation of the facilities is described in the following paragraphs.

Fitzpatrick, F.C.

1982-12-01

296

ACCIDENT ANALYSES & CONTROL OPTIONS IN SUPPORT OF THE SLUDGE WATER SYSTEM SAFETY ANALYSIS  

SciTech Connect

This report documents the accident analyses and nuclear safety control options for use in Revision 7 of HNF-SD-WM-SAR-062, ''K Basins Safety Analysis Report'' and Revision 4 of HNF-SD-SNF-TSR-001, ''Technical Safety Requirements - 100 KE and 100 KW Fuel Storage Basins''. These documents will define the authorization basis for Sludge Water System (SWS) operations. This report follows the guidance of DOE-STD-3009-94, ''Preparation Guide for US. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports'', for calculating onsite and offsite consequences. The accident analysis summary is shown in Table ES-1 below. While this document describes and discusses potential control options to either mitigate or prevent the accidents discussed herein, it should be made clear that the final control selection for any accident is determined and presented in HNF-SD-WM-SAR-062.

WILLIAMS, J.C.

2003-11-15

297

Pretreatment of wastewater: optimal coagulant selection using Partial Order Scaling Analysis (POSA).  

PubMed

Jar-test is a well-known tool for chemical selection for physical-chemical wastewater treatment. Jar test results show the treatment efficiency in terms of suspended matter and organic matter removal. However, in spite of having all these results, coagulant selection is not an easy task because one coagulant can remove efficiently the suspended solids but at the same time increase the conductivity. This makes the final selection of coagulants very dependent on the relative importance assigned to each measured parameter. In this paper, the use of Partial Order Scaling Analysis (POSA) and multi-criteria decision analysis is proposed to help the selection of the coagulant and its concentration in a sequencing batch reactor (SBR). Therefore, starting from the parameters fixed by the jar-test results, these techniques will allow to weight these parameters, according to the judgments of wastewater experts, and to establish priorities among coagulants. An evaluation of two commonly used coagulation/flocculation aids (Alum and Ferric Chloride) was conducted and based on jar tests and POSA model, Ferric Chloride (100 ppm) was the best choice. The results obtained show that POSA and multi-criteria techniques are useful tools to select the optimal chemicals for the physical-technical treatment. PMID:21561709

Tzfati, Eran; Sein, Maya; Rubinov, Angelika; Raveh, Adi; Bick, Amos

2011-06-15

298

Prediction for human intelligence using morphometric characteristics of cortical surface: partial least square analysis.  

PubMed

A number of imaging studies have reported neuroanatomical correlates of human intelligence with various morphological characteristics of the cerebral cortex. However, it is not yet clear whether these morphological properties of the cerebral cortex account for human intelligence. We assumed that the complex structure of the cerebral cortex could be explained effectively considering cortical thickness, surface area, sulcal depth and absolute mean curvature together. In 78 young healthy adults (age range: 17-27, male/female: 39/39), we used the full-scale intelligence quotient (FSIQ) and the cortical measurements calculated in native space from each subject to determine how much combining various cortical measures explained human intelligence. Since each cortical measure is thought to be not independent but highly inter-related, we applied partial least square (PLS) regression, which is one of the most promising multivariate analysis approaches, to overcome multicollinearity among cortical measures. Our results showed that 30% of FSIQ was explained by the first latent variable extracted from PLS regression analysis. Although it is difficult to relate the first derived latent variable with specific anatomy, we found that cortical thickness measures had a substantial impact on the PLS model supporting the most significant factor accounting for FSIQ. Our results presented here strongly suggest that the new predictor combining different morphometric properties of complex cortical structure is well suited for predicting human intelligence. PMID:23643979

Yang, J-J; Yoon, U; Yun, H J; Im, K; Choi, Y Y; Lee, K H; Park, H; Hough, M G; Lee, J-M

2013-08-29

299

Partial sequence analysis of B2L gene of Brazilian orf viruses from sheep and goats.  

PubMed

We herein describe the partial nucleotide sequencing and phylogenetic analysis of the B2L gene of seventeen Brazilian orf viruses (ORFV). Seventeen viruses were recovered from outbreaks of contagious ecthyma in sheep and goats in four states in Southern and Northeast country, and three from commercial vaccines. Most analyzed viruses were associated with outbreaks of classical contagious ecthyma, with lip, nostrils and labial commissure involvement, yet udder/teat, feet, vulvar and disseminated lesions were also reported in some cases. Nucleotide sequence analysis revealed a high degree of B2L similarity among sheep sequences (>99%) regardless the geographic origin, and a remarkable high identity for the two goat isolates (>99.8%), with similarity dropping to below 99% when comparing viruses from the two species. A phylogenetic tree grouped most sheep and goat viruses on different branches. In addition, sequence alignment allowed the identification of up to six scattered nucleotide changes that were predominant and more consistent in goat isolates, including a number of sequences from other continents. Thus, in spite of the high nucleotide similarity, different degrees of similarity and discrete nucleotide changes in the B2L gene may help in grouping ORFV viruses according to host species. PMID:23200438

Schmidt, Candice; Cargnelutti, Juliana F; Brum, Mário C S; Traesel, Carolina K; Weiblen, Rudi; Flores, Eduardo F

2013-02-22

300

Thread safety in an MPI implementation : requirements and analysis.  

SciTech Connect

The MPI-2 Standard has carefully specified the interaction between MPI and user-created threads. The goal of this specification is to allow users to write multithreaded MPI programs while also allowing MPI implementations to deliver high performance. However, a simple reading of the thread-safety specification does not reveal what its implications are for an implementation and what implementers must be aware (and careful) of. In this paper, we describe and analyze what the MPI Standard says about thread-safety and what it implies for an implementation. We classify the MPI functions based on their thread-safety requirements and discuss several issues to consider when implementing thread-safety in MPI. We use the example of generating new context ids (required for creating new communicators) to demonstrate how a simple solution for the single-threaded case does not naturally extend to the multithreaded case and how a naove thread-safe algorithm can be expensive. We then present an algorithm for generating context ids that works efficiently in both single-threaded and multithreaded cases.

Gropp, W.; Thakur, R.; Mathematics and Computer Science

2007-09-01

301

An Analysis of Farm Injuries and Safety Practices in Mississippi  

Microsoft Academic Search

In Mississippi, agriculture is the most dangerous industry employing over 30% of the state's workforce. Records from the Mississippi Cooperative Extension Service indicated that 18 tractor deaths occurred in 1997, a new all-time record. Also, there were two additional deaths involving other farm machinery. This study was designed to determine the magnitude of farm injuries, safety practices, and educational programs

Carey L. Ford; Terence L. Lynch

2000-01-01

302

Robot-assisted partial nephrectomy: analysis of the first 100 cases from a single institution  

Microsoft Academic Search

Robot-assisted partial nephrectomy (RAPN) is an alternative to open and laparoscopic partial nephrectomy for small renal tumors.\\u000a Our objectives were to report our experience and short-term outcomes from the first 100 cases of robot-assisted partial nephrectomy\\u000a (RAPN) performed at a single institution, as well as to evaluate the effect of the learning curve and identify any factors\\u000a associated with adverse

Scott Tobis; Sriram Venigalla; Joy K. Knopf; Emelian Scosyrev; Erdal N. Erturk; Dragan J. Golijanin; Jean V. Joseph; Hani Rashid; Guan Wu

303

Robot-assisted versus laparoscopic partial nephrectomy for localized renal tumors: a meta-analysis  

PubMed Central

Background: Robot-assisted partial nephrectomy (RAPN) is being performed more frequently for the minimally invasive management of localized renal tumors. However, it’s unclear whether RAPN is more efficacious than the standard laparoscopic partial nephrectomy (LPN). The objective of this meta-analysis is to compare RAPN and LPN in terms of perioperative and oncologic outcomes for the treatment of localized renal tumors. Methods: A systematic search of electronic databases including MEDLINE, EMBASE and OVID was conducted. Comparative studies comparing RAPN and LPN for the treatment of localized renal tumors were regarded eligible. The mean difference (MD), odds ratio (OR) and their corresponding 95% confidence intervals (CI) were calculated for each outcome. The methodologic quality of the included studies was evaluated using the strict criteria of the Newcastle-Ottawa scale. Results: 14 comparative studies (n = 1539 participants) were included in the present meta-analysis. Operative time was similar for RAPN and LPN (MD = 6.33, 95% CI [-23.93, 36.59]), however, warm ischemia time favored RAPN (MD = -3.29, 95% CI [-6.47, -0.10]). There was no significant difference in estimated blood loss (EBL) (MD = -42.24, 95% CI [-87.10, 2.61]) and length of stay (LOS) (MD = -0.29, 95% CI [-0.89, 0.32]). The incidence of intraoperative complications was similar for RAPN and LPN (OR = 0.68, 95% CI [0.29, 1.58]), as well as incidence of postoperative minor complications (OR = 1.10, 95% CI [0.80, 1.51]) and postoperative major complications distributions by Clavien classification (OR = 0.99, 95% CI [0.61, 1.61]). In addition, no significant difference was found in terms of positive surgical margin rate (OR = 1.12, 95% CI [0.56, 2.25]). Conclusions: RAPN had similar operative time, LOS, EBL, and perioperative complications compared with LPN, as well as positive margin rates. RAPN appears to offer the advantage of decreased WIT compared with LPN. Studies with long-term follow up are needed to compare RAPN and LPN in terms of long-term complications and oncologic outcomes. PMID:25663973

Zhang, Xiaolong; Yan, Jiajun; Ren, Yu; Shen, Chong; Ying, Xiangrong; Pan, Shouhua

2014-01-01

304

Dissecting the space-time structure of tree-ring datasets using the partial triadic analysis.  

PubMed

Tree-ring datasets are used in a variety of circumstances, including archeology, climatology, forest ecology, and wood technology. These data are based on microdensity profiles and consist of a set of tree-ring descriptors, such as ring width or early/latewood density, measured for a set of individual trees. Because successive rings correspond to successive years, the resulting dataset is a ring variables × trees × time datacube. Multivariate statistical analyses, such as principal component analysis, have been widely used for extracting worthwhile information from ring datasets, but they typically address two-way matrices, such as ring variables × trees or ring variables × time. Here, we explore the potential of the partial triadic analysis (PTA), a multivariate method dedicated to the analysis of three-way datasets, to apprehend the space-time structure of tree-ring datasets. We analyzed a set of 11 tree-ring descriptors measured in 149 georeferenced individuals of European larch (Larix decidua Miller) during the period of 1967-2007. The processing of densitometry profiles led to a set of ring descriptors for each tree and for each year from 1967-2007. The resulting three-way data table was subjected to two distinct analyses in order to explore i) the temporal evolution of spatial structures and ii) the spatial structure of temporal dynamics. We report the presence of a spatial structure common to the different years, highlighting the inter-individual variability of the ring descriptors at the stand scale. We found a temporal trajectory common to the trees that could be separated into a high and low frequency signal, corresponding to inter-annual variations possibly related to defoliation events and a long-term trend possibly related to climate change. We conclude that PTA is a powerful tool to unravel and hierarchize the different sources of variation within tree-ring datasets. PMID:25247299

Rossi, Jean-Pierre; Nardin, Maxime; Godefroid, Martin; Ruiz-Diaz, Manuela; Sergent, Anne-Sophie; Martinez-Meier, Alejandro; Pâques, Luc; Rozenberg, Philippe

2014-01-01

305

Dissecting the Space-Time Structure of Tree-Ring Datasets Using the Partial Triadic Analysis  

PubMed Central

Tree-ring datasets are used in a variety of circumstances, including archeology, climatology, forest ecology, and wood technology. These data are based on microdensity profiles and consist of a set of tree-ring descriptors, such as ring width or early/latewood density, measured for a set of individual trees. Because successive rings correspond to successive years, the resulting dataset is a ring variables × trees × time datacube. Multivariate statistical analyses, such as principal component analysis, have been widely used for extracting worthwhile information from ring datasets, but they typically address two-way matrices, such as ring variables × trees or ring variables × time. Here, we explore the potential of the partial triadic analysis (PTA), a multivariate method dedicated to the analysis of three-way datasets, to apprehend the space-time structure of tree-ring datasets. We analyzed a set of 11 tree-ring descriptors measured in 149 georeferenced individuals of European larch (Larix decidua Miller) during the period of 1967–2007. The processing of densitometry profiles led to a set of ring descriptors for each tree and for each year from 1967–2007. The resulting three-way data table was subjected to two distinct analyses in order to explore i) the temporal evolution of spatial structures and ii) the spatial structure of temporal dynamics. We report the presence of a spatial structure common to the different years, highlighting the inter-individual variability of the ring descriptors at the stand scale. We found a temporal trajectory common to the trees that could be separated into a high and low frequency signal, corresponding to inter-annual variations possibly related to defoliation events and a long-term trend possibly related to climate change. We conclude that PTA is a powerful tool to unravel and hierarchize the different sources of variation within tree-ring datasets. PMID:25247299

Rossi, Jean-Pierre; Nardin, Maxime; Godefroid, Martin; Ruiz-Diaz, Manuela; Sergent, Anne-Sophie; Martinez-Meier, Alejandro; Pâques, Luc; Rozenberg, Philippe

2014-01-01

306

BESAFE II: Accident safety analysis code for MFE reactor designs  

NASA Astrophysics Data System (ADS)

The viability of controlled thermonuclear fusion as an alternative energy source hinges on its desirability from an economic and an environmental and safety standpoint. It is the latter which is the focus of this thesis. For magnetic fusion energy (MFE) devices, the safety concerns equate to a design's behavior during a worst-case accident scenario which is the loss of coolant accident (LOCA). In this dissertation, we examine the behavior of MFE devices during a LOCA and how this behavior relates to the safety characteristics of the machine; in particular the acute, whole-body, early dose. In doing so, we have produced an accident safety code, BESAFE II, now available to the fusion reactor design community. The Appendix constitutes the User's Manual for BESAFE II. The theory behind early dose calculations including the mobilization of activation products is presented in Chapter 2. Since mobilization of activation products is a strong function of temperature, it becomes necessary to calculate the thermal response of a design during a LOCA in order to determine the fraction of the activation products which are mobilized and thus become the source for the dose. The code BESAFE II is designed to determine the temperature history of each region of a design and determine the resulting mobilization of activation products at each point in time during the LOCA. The BESAFE II methodology is discussed in Chapter 4, followed by demonstrations of its use for two reference design cases: a PCA-Li tokamak and a SiC-He tokamak. Of these two cases, it is shown that the SiC-He tokamak is a better design from an accident safety standpoint than the PCA-Li tokamak. It is also found that doses derived from temperature-dependent mobilization data are different than those predicted using set mobilization categories such as those that involve Piet fractions. This demonstrates the need for more experimental data on fusion materials. The possibility for future improvements and modifications to BESAFE II is discussed in Chapter 6, for example, by adding additional environmental indices such as a waste disposal index. The biggest improvement to BESAFE II would be an increase in the database of activation product mobilization for a larger spectrum of fusion reactor materials. The ultimate goal we have is for BESAFE II to become part of a systems design program which would include economic factors and allow both safety and the cost of electricity to influence design.

Sevigny, Lawrence Michael

307

An analysis of electronic health record-related patient safety concerns  

PubMed Central

Objective A recent Institute of Medicine report called for attention to safety issues related to electronic health records (EHRs). We analyzed EHR-related safety concerns reported within a large, integrated healthcare system. Methods The Informatics Patient Safety Office of the Veterans Health Administration (VA) maintains a non-punitive, voluntary reporting system to collect and investigate EHR-related safety concerns (ie, adverse events, potential events, and near misses). We analyzed completed investigations using an eight-dimension sociotechnical conceptual model that accounted for both technical and non-technical dimensions of safety. Using the framework analysis approach to qualitative data, we identified emergent and recurring safety concerns common to multiple reports. Results We extracted 100 consecutive, unique, closed investigations between August 2009 and May 2013 from 344 reported incidents. Seventy-four involved unsafe technology and 25 involved unsafe use of technology. A majority (70%) involved two or more model dimensions. Most often, non-technical dimensions such as workflow, policies, and personnel interacted in a complex fashion with technical dimensions such as software/hardware, content, and user interface to produce safety concerns. Most (94%) safety concerns related to either unmet data-display needs in the EHR (ie, displayed information available to the end user failed to reduce uncertainty or led to increased potential for patient harm), software upgrades or modifications, data transmission between components of the EHR, or ‘hidden dependencies’ within the EHR. Discussion EHR-related safety concerns involving both unsafe technology and unsafe use of technology persist long after ‘go-live’ and despite the sophisticated EHR infrastructure represented in our data source. Currently, few healthcare institutions have reporting and analysis capabilities similar to the VA. Conclusions Because EHR-related safety concerns have complex sociotechnical origins, institutions with long-standing as well as recent EHR implementations should build a robust infrastructure to monitor and learn from them. PMID:24951796

Meeks, Derek W; Smith, Michael W; Taylor, Lesley; Sittig, Dean F; Scott, Jean M; Singh, Hardeep

2014-01-01

308

Analysis of Aviation Safety Reporting System Incident Data Associated with the Technical Challenges of the Atmospheric Environment Safety Technology Project  

NASA Technical Reports Server (NTRS)

This study analyzed aircraft incidents in the NASA Aviation Safety Reporting System (ASRS) that apply to two of the three technical challenges (TCs) in NASA's Aviation Safety Program's Atmospheric Environment Safety Technology Project. The aircraft incidents are related to airframe icing and atmospheric hazards TCs. The study reviewed incidents that listed their primary problem as weather or environment-nonweather between 1994 and 2011 for aircraft defined by Federal Aviation Regulations (FAR) Parts 121, 135, and 91. The study investigated the phases of flight, a variety of anomalies, flight conditions, and incidents by FAR part, along with other categories. The first part of the analysis focused on airframe-icing-related incidents and found 275 incidents out of 3526 weather-related incidents over the 18-yr period. The second portion of the study focused on atmospheric hazards and found 4647 incidents over the same time period. Atmospheric hazards-related incidents included a range of conditions from clear air turbulence and wake vortex, to controlled flight toward terrain, ground encounters, and incursions.

Withrow, Colleen A.; Reveley, Mary S.

2014-01-01

309

A meta-analysis of personality and workplace safety: Addressing unanswered questions.  

PubMed

[Correction Notice: An Erratum for this article was reported in Vol 100(2) of Journal of Applied Psychology (see record 2015-08139-001). Table 3 contained formatting errors. Minus signs used to indicate negative statistical estimates within the table were inadvertently changed to m-dashes. All versions of this article have been corrected.] The purpose of this meta-analysis was to address unanswered questions regarding the associations between personality and workplace safety by (a) clarifying the magnitude and meaning of these associations with both broad and facet-level personality traits, (b) delineating how personality is associated with workplace safety, and (c) testing the relative importance of personality in comparison to perceptions of the social context of safety (i.e., safety climate) in predicting safety-related behavior. Our results revealed that whereas agreeableness and conscientiousness were negatively associated with unsafe behaviors, extraversion and neuroticism were positively associated with them. Of these traits, agreeableness accounted for the largest proportion of explained variance in safety-related behavior and openness to experience was unrelated. At the facet level, sensation seeking, altruism, anger, and impulsiveness were all meaningfully associated with safety-related behavior, though sensation seeking was the only facet that demonstrated a stronger relationship than its parent trait (i.e., extraversion). In addition, meta-analytic path modeling supported the theoretical expectation that personality's associations with accidents are mediated by safety-related behavior. Finally, although safety climate perceptions accounted for the majority of explained variance in safety-related behavior, personality traits (i.e., agreeableness, conscientiousness, neuroticism) still accounted for a unique and substantive proportion of the explained variance. Taken together, these results substantiate the value of considering personality traits as key correlates of workplace safety. (PsycINFO Database Record (c) 2015 APA, all rights reserved). PMID:25243998

Beus, Jeremy M; Dhanani, Lindsay Y; McCord, Mallory A

2015-03-01

310

National Synchrotron Light Source safety-analysis report  

SciTech Connect

This document covers all of the safety issues relating to the design and operation of the storage rings and injection system of the National Synchrotron Light Source. The building systems for fire protection, access and egress are described together with air and other gaseous control or venting systems. Details of shielding against prompt bremstrahlung radiation and synchrotron radiation are described and the administrative requirements to be satisfied for operation of a beam line at the facility are given.

Batchelor, K. (ed.)

1982-07-01

311

Process hazards analysis (PrHA) program, bridging accident analyses and operational safety  

SciTech Connect

Recently the Final Safety Analysis Report (FSAR) for the Plutonium Facility at Los Alamos National Laboratory, Technical Area 55 (TA-55) was revised and submitted to the US. Department of Energy (DOE). As a part of this effort, over seventy Process Hazards Analyses (PrHAs) were written and/or revised over the six years prior to the FSAR revision. TA-55 is a research, development, and production nuclear facility that primarily supports US. defense and space programs. Nuclear fuels and material research; material recovery, refining and analyses; and the casting, machining and fabrication of plutonium components are some of the activities conducted at TA-35. These operations involve a wide variety of industrial, chemical and nuclear hazards. Operational personnel along with safety analysts work as a team to prepare the PrHA. PrHAs describe the process; identi fy the hazards; and analyze hazards including determining hazard scenarios, their likelihood, and consequences. In addition, the interaction of the process to facility systems, structures and operational specific protective features are part of the PrHA. This information is rolled-up to determine bounding accidents and mitigating systems and structures. Further detailed accident analysis is performed for the bounding accidents and included in the FSAR. The FSAR is part of the Documented Safety Analysis (DSA) that defines the safety envelope for all facility operations in order to protect the worker, the public, and the environment. The DSA is in compliance with the US. Code of Federal Regulations, 10 CFR 830, Nuclear Safety Management and is approved by DOE. The DSA sets forth the bounding conditions necessary for the safe operation for the facility and is essentially a 'license to operate.' Safely of day-to-day operations is based on Hazard Control Plans (HCPs). Hazards are initially identified in the PrI-IA for the specific operation and act as input to the HCP. Specific protective features important to worker safety are incorporated so the worker can readily identify the safety parameters of the their work. System safety tools such as Preliminary Hazard Analysis, What-If Analysis, Hazard and Operability Analysis as well as other techniques as necessary provide the groundwork for both determining bounding conditions for facility safety, operational safety, and day-to-clay worker safety.

Richardson, J. A. (Jeanne A.); McKernan, S. A. (Stuart A.); Vigil, M. J. (Michael J.)

2003-01-01

312

Analysis of developed transition road safety barrier systems.  

PubMed

Road safety barriers protect vehicles from roadside hazards by redirecting errant vehicles in a safe manner as well as providing high levels of safety during and after impact. This paper focused on transition safety barrier systems which were located at the point of attachment between a bridge and roadside barriers. The aim of this study was to provide an overview of the behavior of transition systems located at upstream bridge rail with different designs and performance levels. Design factors such as occupant risk and vehicle trajectory for different systems were collected and compared. To achieve this aim a comprehensive database was developed using previous studies. The comparison showed that Test 3-21, which is conducted by impacting a pickup truck with speed of 100 km/h and angle of 25° to transition system, was the most severe test. Occupant impact velocity and ridedown acceleration for heavy vehicles were lower than the amounts for passenger cars and pickup trucks, and in most cases higher occupant lateral impact ridedown acceleration was observed on vehicles subjected to higher levels of damage. The best transition system was selected to give optimum performance which reduced occupant risk factors using the similar crashes in accordance with Test 3-21. PMID:23820073

Soltani, Mehrtash; Moghaddam, Taher Baghaee; Karim, Mohamed Rehan; Sulong, N H Ramli

2013-10-01

313

Model-Driven Safety Analysis of Closed-Loop Medical Systems  

PubMed Central

In modern hospitals, patients are treated using a wide array of medical devices that are increasingly interacting with each other over the network, thus offering a perfect example of a cyber-physical system. We study the safety of a medical device system for the physiologic closed-loop control of drug infusion. The main contribution of the paper is the verification approach for the safety properties of closed-loop medical device systems. We demonstrate, using a case study, that the approach can be applied to a system of clinical importance. Our method combines simulation-based analysis of a detailed model of the system that contains continuous patient dynamics with model checking of a more abstract timed automata model. We show that the relationship between the two models preserves the crucial aspect of the timing behavior that ensures the conservativeness of the safety analysis. We also describe system design that can provide open-loop safety under network failure. PMID:24177176

Pajic, Miroslav; Mangharam, Rahul; Sokolsky, Oleg; Arney, David; Goldman, Julian; Lee, Insup

2013-01-01

314

The development of a facility for partial body in vivo activation analysis using californium-252 neutron sources  

Microsoft Academic Search

Consideration of the nuclear and physical properties of 252Cf, which is spontaneously fissile, suggests that it is a very suitable radioisotopic source of neutrons for partial body i n vivo activation analysis. A facility is described, which has been developed for use in the clinical environment, and is both simple in construction and operation and economical. The performance in the

Keith Boddy; Ian Robertson; Dimitris Glaros

1974-01-01

315

A Comparison of Approaches for the Analysis of Interaction Effects between Latent Variables Using Partial Least Squares Path Modeling  

ERIC Educational Resources Information Center

In social and business sciences, the importance of the analysis of interaction effects between manifest as well as latent variables steadily increases. Researchers using partial least squares (PLS) to analyze interaction effects between latent variables need an overview of the available approaches as well as their suitability. This article…

Henseler, Jorg; Chin, Wynne W.

2010-01-01

316

Partial differential equation-based approach for empirical mode decomposition: application on image analysis.  

PubMed

The major problem with the empirical mode decomposition (EMD) algorithm is its lack of a theoretical framework. So, it is difficult to characterize and evaluate this approach. In this paper, we propose, in the 2-D case, the use of an alternative implementation to the algorithmic definition of the so-called "sifting process" used in the original Huang's EMD method. This approach, especially based on partial differential equations (PDEs), was presented by Niang in previous works, in 2005 and 2007, and relies on a nonlinear diffusion-based filtering process to solve the mean envelope estimation problem. In the 1-D case, the efficiency of the PDE-based method, compared to the original EMD algorithmic version, was also illustrated in a recent paper. Recently, several 2-D extensions of the EMD method have been proposed. Despite some effort, 2-D versions for EMD appear poorly performing and are very time consuming. So in this paper, an extension to the 2-D space of the PDE-based approach is extensively described. This approach has been applied in cases of both signal and image decomposition. The obtained results confirm the usefulness of the new PDE-based sifting process for the decomposition of various kinds of data. Some results have been provided in the case of image decomposition. The effectiveness of the approach encourages its use in a number of signal and image applications such as denoising, detrending, or texture analysis. PMID:22614651

Niang, Oumar; Thioune, Abdoulaye; El Gueirea, Mouhamed Cheikh; Deléchelle, Eric; Lemoine, Jacques

2012-09-01

317

Multiple factor analysis of urine leaks after retroperitoneal laparoscopic partial nephrectomy.  

PubMed

Laparoscopic partial nephrectomy (LPN) is increasingly becoming a definitive therapeutic option for the treatment of small (less than 4 cm) and select moderate-sized (less than 7 cm) renal tumors. Postoperative hemorrhage and urine leak are the most pertinent complications after nephron-sparing surgery, open or laparoscopic. To our knowledge, the risk factors of urine leaks after retroperitoneal LPN have not been studied. We retrospectively analyzed our experience with retroperitoneal LPN to determine risk factors for postoperative urine leak complications. The records of 236 patients who underwent retroperitoneal LPN for renal tumor from March 2003 to October 2010 were reviewed retrospectively. Urine leak was strictly defined as continued urine output from the drain after postoperative day 2. In our series, 39 patients (16.5%) had urine leak complications. On multivariate analysis, mean estimated blood loss (p = 0.0120) and computed tomography angiogram (CTA) examination (p = 0.0286) were independent predictive factors of urine leaks. Moreover, the intraoperative blood loss was significantly reduced in patients undergoing CTA examination (p = 0.0375). Our investigation showed that factors such as intraoperative blood loss and CTA examination are predictors of urine leaks after retroperitoneal LPN. Less intraoperative blood loss to obtain a clear operative field and meticulous suturing technique are necessary to reduce urine leak probability. PMID:22004840

Wang, Ping; Xia, Dan; Wang, Shuo

2011-01-01

318

Radioisotopic neutron transmission spectrometry: Quantitative analysis by using partial least-squares method.  

PubMed

Neutron spectrometry, based on the scattering of high energy fast neutrons from a radioisotope and slowing-down by the light hydrogen atoms, is a useful technique for non-destructive, quantitative measurement of hydrogen content because it has a large measuring volume, and is not affected by temperature, pressure, pH value and color. The most common choice for radioisotope neutron source is (252)Cf or (241)Am-Be. In this study, (252)Cf with a neutron flux of 6.3x10(6)n/s has been used as an attractive neutron source because of its high flux neutron and weak radioactivity. Pulse-height neutron spectra have been obtained by using in-house built radioisotopic neutron spectrometric system equipped with (3)He detector and multi-channel analyzer, including a neutron shield. As a preliminary study, polyethylene block (density of approximately 0.947g/cc and area of 40cmx25cm) was used for the determination of hydrogen content by using multivariate calibration models, depending on the thickness of the block. Compared with the results obtained from a simple linear calibration model, partial least-squares regression (PLSR) method offered a better performance in a quantitative data analysis. It also revealed that the PLSR method in a neutron spectrometric system can be promising in the real-time, online monitoring of the powder process to determine the content of any type of molecules containing hydrogen nuclei. PMID:19285419

Kim, Jong-Yun; Choi, Yong Suk; Park, Yong Joon; Jung, Sung-Hee

2009-01-01

319

Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA).  

PubMed

The aims of the study were to differentiate Pueraria lobata from its related species Pueraria thomsonii and to examine the raw herbal material used in manufacturing kudzu root granules using partial least square discriminant analysis (PLS-DA). Sixty-four raw materials of P. lobata and P. thomsonii and kudzu root-labelled granules were analysed by ultra performance liquid chromatography. To differentiate P. lobata from P. thomsonii, PLS-DA models using the variables selected from the entire chromatograms, genetic algorithm (GA), successive projection algorithm (SPA), puerarin alone and six selected peaks were employed. The models constructed by GA and SPA demonstrated superior classification ability and lower model's complexity as compared to the model based on the entire chromatographic matrix, whilst the model constructed by the six selected peaks was comparable to the entire chromatographic model. The model established by puerarin alone showed inferior classification ability. In addition, the PLS-DA models constructed by the entire chromatographic matrix, GA, SPA and the six selected peaks showed that four brands out of seventeen granules were mislabelled as P. lobata. In conclusion, PLS-DA is a promising procedure for differentiating Pueraria species and determining raw material used in commercial products. PMID:23777642

Wong, Ka H; Razmovski-Naumovski, Valentina; Li, Kong M; Li, George Q; Chan, Kelvin

2013-10-01

320

Bayesian Statistics and Uncertainty Quantification for Safety Boundary Analysis in Complex Systems  

NASA Technical Reports Server (NTRS)

The analysis of a safety-critical system often requires detailed knowledge of safe regions and their highdimensional non-linear boundaries. We present a statistical approach to iteratively detect and characterize the boundaries, which are provided as parameterized shape candidates. Using methods from uncertainty quantification and active learning, we incrementally construct a statistical model from only few simulation runs and obtain statistically sound estimates of the shape parameters for safety boundaries.

He, Yuning; Davies, Misty Dawn

2014-01-01

321

Review of Overall Safety Manual for space nuclear systems. An evaluation of a nuclear safety analysis methodology for plutonium-fueled space nuclear systems  

SciTech Connect

As part of its duties in connection with space missions involving nuclear power sources, the Office of Nuclear Safety (ONS) of the Office of Assistant Secretary for Environmental Protection, Safety, and Emergency Preparedness has been assigned the task of reviewing the Overall Safety Manual (OSM) (memo from B.J. Rock to J.R. Maher, December 1, 1982). The OSM, dated July 1981 and in four volumes, was prepared by NUS Corporation, Rockville, Maryland, for the US Department of Energy. The OSM provides many of the technical models and much of the data which are used by (1) space launch contractors in safety analysis reports and (2) the broader Interagency Nuclear Safety Review Panel (INSRP) safety evaluation reports. If fhs interaction between the OSM, contractors, and INSRP is to work effectively, the OSM must be accurate, comprehensive, understandable, and usable.

Coleman, J.; Inhaber, H.

1984-02-01

322

Hand Safety  

MedlinePLUS

... Hand Safety Fireworks Safety Lawnmower Safety Snowblower Safety Pumpkin Carving Safety Gardening Safety Turkey Carving Safety Removing ... Hand Safety Fireworks Safety Lawnmower Safety Snowblower Safety Pumpkin Carving Safety Gardening Safety Turkey Carving Safety Removing ...

323

Partial sequencing of the bottle gourd genome reveals markers useful for phylogenetic analysis and breeding  

PubMed Central

Background Bottle gourd [Lagenaria siceraria (Mol.) Standl.] is an important cucurbit crop worldwide. Archaeological research indicates that bottle gourd was domesticated more than 10,000 years ago, making it one of the earliest plants cultivated by man. In spite of its widespread importance and long history of cultivation almost nothing has been known about the genome of this species thus far. Results We report here the partial sequencing of bottle gourd genome using the 454 GS-FLX Titanium sequencing platform. A total of 150,253 sequence reads, which were assembled into 3,994 contigs and 82,522 singletons were generated. The total length of the non-redundant singletons/assemblies is 32 Mb, theoretically covering ~ 10% of the bottle gourd genome. Functional annotation of the sequences revealed a broad range of functional types, covering all the three top-level ontologies. Comparison of the gene sequences between bottle gourd and the model cucurbit cucumber (Cucumis sativus) revealed a 90% sequence similarity on average. Using the sequence information, 4395 microsatellite-containing sequences were identified and 400 SSR markers were developed, of which 94% amplified bands of anticipated sizes. Transferability of these markers to four other cucurbit species showed obvious decline with increasing phylogenetic distance. From analyzing polymorphisms of a subset of 14 SSR markers assayed on 44 representative China bottle gourd varieties/landraces, a principal coordinates (PCo) analysis output and a UPGMA-based dendrogram were constructed. Bottle gourd accessions tended to group by fruit shape rather than geographic origin, although in certain subclades the lines from the same or close origin did tend to cluster. Conclusions This work provides an initial basis for genome characterization, gene isolation and comparative genomics analysis in bottle gourd. The SSR markers developed would facilitate marker assisted breeding schemes for efficient introduction of desired traits. PMID:21942996

2011-01-01

324

Predictors of Local Recurrence Following Accelerated Partial Breast Irradiation: A Pooled Analysis  

SciTech Connect

Purpose: To analyze a pooled set of nearly 2,000 patients treated on the American Society of Breast Surgeons (ASBS) Mammosite Registry Trial and at William Beaumont Hospital (WBH) to identify factors associated with local recurrence following accelerated partial breast irradiation (APBI). Methods and Materials: A total of 1,961 women underwent partial breast irradiation between April 1993 and November 2010 as part of the ASBS Registry Trial or at WBH. Rates of ipsilateral breast tumor recurrence (IBTR), regional recurrence (RR), distant metastases (DM), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS) were analyzed for each group and for the pooled cohort. Clinical, pathologic, and treatment-related variables were analyzed including age, tumor stage/size, estrogen receptor status, surgical margins, and lymph node status to determine their association with IBTR. Results: The two groups weres similar, but WBH patients were more frequently node positive, had positive margins, and were less likely to be within the American Society for Radiation Oncology-unsuitable group. At 5 years, the rates of IBTR, RR, DM, DFS, CSS, and OS for the pooled group of patients were 2.9%, 0.5%, 2.4%, 89.1%, 98.5%, and 91.8%, respectively. The 5-year rate of true recurrence/marginal miss was 0.8%. Univariate analysis of IBTR found that negative estrogen receptor status (odds ratio [OR], 2.83, 95% confidence interval 1.55-5.13, p = 0.0007) was the only factor significantly associated with IBTR, while a trend was seen for age less than 50 (OR 1.80, 95% confidence interval 0.90-3.58, p = 0.10). Conclusions: Excellent 5-year outcomes were seen following APBI in over 1,900 patients. Estrogen receptor negativity was the only factor associated with IBTR, while a trend for age less than 50 was noted. Significant differences in factors associated with IBTR were noted between cohorts, suggesting that factors driving IBTR may be predicated based on the risk stratification of the patients being treated.

Shah, Chirag; Wilkinson, John Ben [Department of Radiation Oncology, Beaumont Cancer Institute, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Lyden, Maureen [Biostat Inc., Tampa, Florida (United States); Beitsch, Peter [Dallas Breast Center, Dallas, Texas (United States); Vicini, Frank A., E-mail: fvicini@pol.net [Department of Radiation Oncology, Beaumont Cancer Institute, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States)

2012-04-01

325

An Analysis of Trainers' Perspectives within an Ecological Framework: Factors that Influence Mine Safety Training Processes  

PubMed Central

Background Satisfactory completion of mine safety training is a prerequisite for being hired and for continued employment in the coal industry. Although training includes content to develop skills in a variety of mineworker competencies, research and recommendations continue to specify that specific limitations in the self-escape portion of training still exist and that mineworkers need to be better prepared to respond to emergencies that could occur in their mine. Ecological models are often used to inform the development of health promotion programs but have not been widely applied to occupational health and safety training programs. Methods Nine mine safety trainers participated in in-depth semi-structured interviews. A theoretical analysis of the interviews was completed via an ecological lens. Each level of the social ecological model was used to examine factors that could be addressed both during and after mine safety training. Results The analysis suggests that problems surrounding communication and collaboration, leadership development, and responsibility and accountability at different levels within the mining industry contribute to deficiencies in mineworkers' mastery and maintenance of skills. Conclusion This study offers a new technique to identify limitations in safety training systems and processes. The analysis suggests that training should be developed and disseminated with consideration of various levels—individual, interpersonal, organizational, and community—to promote skills. If factors identified within and between levels are addressed, it may be easier to sustain mineworker competencies that are established during safety training. PMID:25379324

Haas, Emily J.; Hoebbel, Cassandra L.; Rost, Kristen A.

2014-01-01

326

Additional guidance for including nuclear safety equivalency in the Canister Storage Building and Cold Vacuum Drying Facility final safety analysis report  

SciTech Connect

This document provides guidance for the production of safety analysis reports that must meet both DOE Order 5480.23 and STD 3009, and be in compliance with the DOE regulatory policy that imposes certain NRC requirements.

Garvin, L.J.

1997-05-20

327

Analysis of children's textiles and apparel product safety issues using recall data from the US Consumer Product Safety Commission  

Microsoft Academic Search

Given the heightened concerns and awareness among US consumers regarding imported product safety issues, as well as today's businesses' strong involvement with product safety assurance, it is imperative for family and consumer science educators to understand issues surrounding the safety of consumer products. This study analysed product recall data from the US Consumer Product Safety Commission (CPSC) specific to infant

Pamela Norum; Jung Ha-Brookshire

2011-01-01

328

Analysis of children's textiles and apparel product safety issues using recall data from the US Consumer Product Safety Commission  

Microsoft Academic Search

Given the heightened concerns and awareness among US consumers regarding imported product safety issues, as well as today's businesses' strong involvement with product safety assurance, it is imperative for family and consumer science educators to understand issues surrounding the safety of consumer products. This study analysed product recall data from the US Consumer Product Safety Commission (CPSC) specific to infant

Pamela Norum; Jung Ha-Brookshire

2012-01-01

329

Interuser Interference Analysis for Direct-Sequence Spread-Spectrum Systems Part I: Partial-Period Cross-Correlation  

NASA Technical Reports Server (NTRS)

This presentation discusses an analysis approach to evaluate the interuser interference for Direct-Sequence Spread-Spectrum (DSSS) Systems for Space Network (SN) Users. Part I of this analysis shows that the correlation property of pseudo noise (PN) sequences is the critical factor which determines the interuser interference performance of the DSSS system. For non-standard DSSS systems in which PN sequence s period is much larger than one data symbol duration, it is the partial-period cross-correlation that determines the system performance. This study reveals through an example that a well-designed PN sequence set (e.g. Gold Sequence, in which the cross-correlation for a whole-period is well controlled) may have non-controlled partial-period cross-correlation which could cause severe interuser interference for a DSSS system. Since the analytical derivation of performance metric (bit error rate or signal-to-noise ratio) based on partial-period cross-correlation is prohibitive, the performance degradation due to partial-period cross-correlation will be evaluated using simulation in Part II of this analysis in the future.

Ni, Jianjun (David)

2012-01-01

330

Invited Contribution to Q 76: The Use of Risk Analysis to Support Dam Safety Decisions and Management  

E-print Network

ICOLD 20th Congress Invited Contribution to Q 76: The Use of Risk Analysis to Support Dam Safety Decisions and Management DRAFT FOR REVIEW ONLY Portfolio Risk Assessment: A Tool for Managing Dam Safety in the Context of the Owner's Business David S. Bowles Professor and Director, Institute for Dam Safety Risk

Bowles, David S.

331

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2010 CFR

...termination system or command control system, must undergo a sneak circuit analysis. The analysis must demonstrate that there are no latent paths of an unwanted command that could, when all components otherwise function properly, cause the occurrence of an...

2010-01-01

332

Review and Analysis of Development of "Safety by Design" Requirements  

SciTech Connect

This report, the deliverable for Task 4 of the NA-243 Safeguards by Design Work Plan for Fiscal Year 2009, develops the lessons to be learned for the institutionalization of Safeguards By Design (SBD) from the Department of Energy (DOE) experience developing and implementing DOE-STD-1189, Integration of Safety into the Design Process. This experience was selected for study because of the similarity of the challenges of integrating safety and safeguards into the design process. Development of DOE-STD-1189 began in January 2006 and the standard was issued for implementation in March 2008. The process was much more time consuming than originally anticipated and might not have come to fruition had senior DOE management been less committed to its success. Potentially valuable lessons can be learned from both the content and presentation of the integration approach in DOE-STD-1189 and from the DOE experience in developing and implementing DOE-STD-1189. These lessons are important because the instutionalization of SBD does not yet appear to have the level of senior management commitment afforded development and implementation of DOE-STD-1189.

Vance, Scott A.; Hockert, John

2009-10-20

333

Stage Right operational safety analysis and evaluation of Pantex personnel operations  

SciTech Connect

This report documents a study (Stage Right Operational Safety Analysis) that was performed to evaluate the effects of new Stage Right operations on the safety of Pantex personnel who perform the operations and maintain the equipment. The primary concern of the evaluation was for personnel safety during Stage Right operations, but operations equipment damage and degradation also were taken into account. This analysis evaluates safety of the work process in the staging of dismantled nuclear weapon pits within the modified Richmond magazines only. This Stage Right Process and Operational Safety Analysis includes the following processes: moving the pelletized drums from the pallet trailer to the pallet turner, staging of pallets and removal of pallets from the magazine, recovery from an incident in a magazine, setting up, opening, and closing a Zone 4 magazine, inventory of pelletized drums in the magazines, transporting pelletized drums from Zone 12 to Zone 4, and maintenance on the shielded lift truck that involves removal of the cab shielding. The analysis includes the following undesirable consequences: injury to personnel, breach of an AL-R8 container, drop of a loaded pallet, damage to equipment, and equipment unreliability.

Rountree, S.L.K.; Whitehurst, H.O.; Tomlin, E.H.; Restrepo, L.F. [Sandia National Labs., Albuquerque, NM (United States); White, J. [Sandia National Labs., Albuquerque, NM (United States)]|[Intera, Albuquerque, NM (United States)

1995-01-01

334

Information System Hazard Analysis: A Method for Identifying Technology-induced Latent Errors for Safety.  

PubMed

Many health information and communication technologies (ICT) are safety-critical; moreover, reports of technology-induced adverse events related to them are plentiful in the literature. Despite repeated criticism and calls to action, recent data collected by the Institute of Medicine (IOM) and other organization do not indicate significant improvements with respect to the safety of health ICT systems. A large part of the industry still operates on a reactive "break & patch" model; the application of pro-active, systematic hazard analysis methods for engineering ICT that produce "safe by design" products is sparse. This paper applies one such method: Information System Hazard Analysis (ISHA). ISHA adapts and combines hazard analysis techniques from other safety-critical domains and customizes them for ICT. We provide an overview of the steps involved in ISHA and describe. PMID:25676999

Weber, Jens H; Mason-Blakley, Fieran; Price, Morgan

2015-01-01

335

Effect of axial loads on implant-supported partial fixed prostheses by strain gauge analysis  

PubMed Central

Objectives The present study used strain gauge analysis to perform an in vitro evaluation of the effect of axial loading on 3 elements of implant-supported partial fixed prostheses, varying the type of prosthetic cylinder and the loading points. Material and methods Three internal hexagon implants were linearly embedded in a polyurethane block. Microunit abutments were connected to the implants applying a torque of 20 Ncm, and prefabricated Co-Cr cylinders and plastic prosthetic cylinders were screwed onto the abutments, which received standard patterns cast in Co-Cr alloy (n=5). Four strain gauges (SG) were bonded onto the surface of the block tangentially to the implants, SG 01 mesially to implant 1, SG 02 and SG 03 mesially and distally to implant 2, respectively, and SG 04 distally to implant 3. Each metallic structure was screwed onto the abutments with a 10 Ncm torque and an axial load of 30 kg was applied at five predetermined points (A, B, C, D, E). The data obtained from the strain gauge analyses were analyzed statistically by RM ANOVA and Tukey's test, with a level of significance of p<0.05. Results There was a significant difference for the loading point (p=0.0001), with point B generating the smallest microdeformation (239.49 ??) and point D the highest (442.77 ??). No significant difference was found for the cylinder type (p=0.748). Conclusions It was concluded that the type of cylinder did not affect in the magnitude of microdeformation, but the axial loading location influenced this magnitude. PMID:22230995

de VASCONCELLOS, Luis Gustavo Oliveira; NISHIOKA, Renato Sussumu; de VASCONCELLOS, Luana Marotta Reis; NISHIOKA, Lea Nogueira Braulino de Melo

2011-01-01

336

Mitochondrial gene rearrangements and partial genome duplications detected by multigene asymmetric compositional bias analysis.  

PubMed

Asymmetric compositional and mutation bias between the two strands occurs in mitochondrial genomes, and an asymmetric mechanism of mtDNA replication is a potential source of this bias. Some evidence indicates that during replication the heavy strand is subject to a gradient of time spent in a single-stranded state (D (ssH)) and a gradient of mutational damage. The nucleotide composition bias among genes varies with D (ssH). Consequently, partial genome duplications (PGD) will alter the skew for genes located downstream of the duplication, relatively to nascent light strand synthesis, and in the same way, gene rearrangements (GRr) will affect genes by changing their skews. We examined cases where there had been PGD or GRr and determined whether this left a trace in the form of unusual patterns of base composition. We compared the skew of genes differently located on the mtDNA genome of previously published whole mtDNA genomes from amphibians, a group that shows considerable levels of both GRr and PGD. After observing a significant correlation between AT and GC skew with D (ssH) at fourfold redundant sites, we ran our analysis and detected 31.3% of the species with GRr and/or PGD. By comparing the nucleotide composition at fourfold redundant sites in normal and "abnormal" species, we found that A/C variation occurs and is associated with GRr/PGD. These results show that by analyzing the nucleotide skews of only three genes, it may be possible to predict some mitochondrial GRr and/or PGD without knowing the complete mtDNA genome sequence. PMID:17075699

Fonseca, Miguel M; Froufe, Elsa; Harris, D James

2006-11-01

337

Station Blackout: A case study in the interaction of mechanistic and probabilistic safety analysis  

SciTech Connect

The ability to better characterize and quantify safety margins is important to improved decision making about nuclear power plant design, operation, and plant life extension. As research and development (R&D) in the light-water reactor (LWR) Sustainability (LWRS) Program and other collaborative efforts yield new data, sensors, and improved scientific understanding of physical processes that govern the aging and degradation of plant SSCs needs and opportunities to better optimize plant safety and performance will become known. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway R&D is to support plant decisions for risk-informed margin management with the aim to improve economics, reliability, and sustain safety of current NPPs. In this paper, we describe the RISMC analysis process illustrating how mechanistic and probabilistic approaches are combined in order to estimate a safety margin. We use the scenario of a “station blackout” wherein offsite power and onsite power is lost, thereby causing a challenge to plant safety systems. We describe the RISMC approach, illustrate the station blackout modeling, and contrast this with traditional risk analysis modeling for this type of accident scenario.

Curtis Smith; Diego Mandelli; Cristian Rabiti

2013-11-01

338

Analysis of partial-reflection data from the solar eclipse of 10 Jul. 1972. [ground-based experiment using vertical incident radio waves partially reflected from D region  

NASA Technical Reports Server (NTRS)

Partial-reflection data collected for the eclipse of July 10, 1972 as well as for July 9 and 11, 1972, are analyzed to determine eclipse effects on D-region electron densities. The partial-reflection experiment was set up to collect data using an on-line PDP-15 computer and DECtape storage. The electron-density profiles show good agreement with results from other eclipses. The partial-reflection programs were changed after the eclipse data collection to improve the operation of the partial-reflection system. These changes were mainly due to expanded computer hardware and have simplified the operations of the system considerably.

Bean, T. A.; Bowhill, S. A.

1973-01-01

339

PWR integrated safety analysis methodology using multi-level coupling algorithm  

NASA Astrophysics Data System (ADS)

Coupled three-dimensional (3D) neutronics/thermal-hydraulic (T-H) system codes give a unique opportunity for a realistic modeling of the plant transients and design basis accidents (DBA) occurring in light water reactors (LWR). Examples of such DBAs are the rod ejection accidents (REA) and the main steam line break (MSLB) that constitute the bounding safety problems for pressurized water reactors (PWR). These accidents involve asymmetric 3D spatial neutronic and T-H effects during the course of the transients. The thermal margins (the peak fuel temperature, and departure from nucleate boiling ratio (DNBR)) are the measures of safety at a particular transient and need to be evaluated as accurate as possible. Modern 3D neutronics/T-H coupled codes estimate the safety margins coarsely on an assembly level, i.e. for an average fuel pin. More accurate prediction of the safety margins requires the evaluation of the transient fuel rod response involving locally coupled neutronics/T-H calculations. The proposed approach is to perform an on-line hot-channel safety analysis not for the whole core but for a selected local region, for example for the highest power loaded fuel assembly. This approach becomes feasible if an on-line algorithm capable to extract the necessary input data for a sub-channel module is available. The necessary input data include the detailed pin-power distributions and the T-H boundary conditions for each sub-channel in the considered problem. Therefore, two potential challenges are faced in the development of refined methodology for evaluation of local safety parameters. One is the development of an efficient transient pin-power reconstruction algorithm with a consistent cross-section modeling. The second is the development of a multi-level coupling algorithm for the T-H boundary and feed-back data exchange between the sub-channel module and the main 3D neutron kinetics/T-H system code, which already uses one level of coupling scheme between 3D neutronics and core thermal-hydraulics models. The major accomplishment of the thesis is the development of an integrated PWR safety analysis methodology with locally refined safety evaluations. This involved introduction of an improved method capable of efficiently restoring the fine pin-power distribution with a high degree of accuracy. In order to apply the methodology to evaluate the safety margins on a pin level, a refined on-line hot channel model was developed accounting for the cross-flow effects. Finally, this methodology was applied to best estimate safety analysis to more accurately calculate the thermal safety margins occurring during a design basis accident in PWR.

Ziabletsev, Dmitri Nickolaevich

340

Safety analysis report for the TRUPACT-II shipping package (condensed version). Volume 1, Rev. 14  

SciTech Connect

The condensed version of the TRUPACT-II Contact Handled Transuranic Waste Safety Analysis Report for Packaging (SARP) contains essential material required by TRUPACT-II users, plus additional contents (payload) information previously submitted to the U.S. Nuclear Regulatory Commission. All or part of the following sections, which are not required by users of the TRUPACT-II, are deleted from the condensed version: (i) structural analysis, (ii) thermal analysis, (iii) containment analysis, (iv) criticality analysis, (v) shielding analysis, and (vi) hypothetical accident test results.

NONE

1994-10-01

341

Effects of relay chatter in seismic probabilistic safety analysis  

SciTech Connect

In the Zion and Indian Point Probabilistic Safety Studies, relay chatter was dismissed as a credible event and hence was not formally included in the analyses. Although little discussion is given in the Zion and Indian Point PSA documentation concerning the basis for this decision, it has been expressed informally that it was assumed that the operators will be able to reset all relays in a timely manner. Currently, it is the opinion of many professionals that this may be an oversimplification. The three basic areas which must be considered in addressing relay chatter include the fragility of the relays per se, the reliability of the operators to reset the relays and finally the systems response aspects. Each of these areas is reviewed and the implications for seismic PSA are discussed. Finally, recommendations for future research are given.

Reed, J.W.; Shiu, K.K.

1985-01-01

342

Risk analysis of Safety Service Patrol (SSP) systems in Virginia.  

PubMed

The transportation infrastructure is a vital backbone of any regional economy as it supports workforce mobility, tourism, and a host of socioeconomic activities. In this article, we specifically examine the incident management function of the transportation infrastructure. In many metropolitan regions, incident management is handled primarily by safety service patrols (SSPs), which monitor and resolve roadway incidents. In Virginia, SSP allocation across highway networks is based typically on average vehicle speeds and incident volumes. This article implements a probabilistic network model that partitions "business as usual" traffic flow with extreme-event scenarios. Results of simulated network scenarios reveal that flexible SSP configurations can improve incident resolution times relative to predetermined SSP assignments. PMID:21605149

Dickey, Brett D; Santos, Joost R

2011-12-01

343

Safety in the globalising knowledge economy: an analysis by paradoxes.  

PubMed

There is a widespread recognition of a 'crisis' in official scientific expertise, related to the increase of 'uncertainty' and the loss of 'trust', and whose cure is believed to lie in 'participation'. I argue that the crisis results from structural features of the globalising knowledge economy, and the contradictory roles of governments, acting both as promoters of global business enterprise and also as regulators on behalf of a sophisticated and suspicious public. I explain the crisis by substituting 'safety' for 'risk' as the operative concept, and also using 'paradox' as an explanatory tool. I produce a closed-cycle paradox, analogous to the classic Catch-22, to exhibit the contradictions in the situation. I discuss ways of resolving these, which include the recognition of policy-critical ignorance and the adoption of the perspective of post-normal science. PMID:11532355

Ravetz, J R

2001-09-14

344

Decision Analysis Tools for Safety, Security, and Sustainability Of Ports and Harbors  

Microsoft Academic Search

Industrial ports and harbors face significant safety, security, and sustainability challenges. Decisions must be made to assess\\u000a risk and allocate risk management resources. Decision analysis has nearly 40 years of successful application to decision challenges.\\u000a We present a comprehensive decision analysis framework that captures the concepts and tools of decision analysis. We use four\\u000a illustrative examples to demonstrate the potential

Gregory Parnell; Jose Rui Figueira; Steven Bennett; N. Bobylev; Michele Del Pup; Jacques Ganoulis; N. Haruvy; Scira Menoni; Francesca Peruzzo; Olivier Salvi; Vardan Sargsyan; Uwe Schlink; Shakinaz El Sheltawi; Debra Schnelle

345

Preliminary Results Obtained in Integrated Safety Analysis of NASA Aviation Safety Program Technologies  

NASA Technical Reports Server (NTRS)

This is a listing of recent unclassified RTO technical publications processed by the NASA Center for AeroSpace Information from January 1, 2001 through March 31, 2001 available on the NASA Aeronautics and Space Database. Contents include 1) Cognitive Task Analysis; 2) RTO Educational Notes; 3) The Capability of Virtual Reality to Meet Military Requirements; 4) Aging Engines, Avionics, Subsystems and Helicopters; 5) RTO Meeting Proceedings; 6) RTO Technical Reports; 7) Low Grazing Angle Clutter...; 8) Verification and Validation Data for Computational Unsteady Aerodynamics; 9) Space Observation Technology; 10) The Human Factor in System Reliability...; 11) Flight Control Design...; 12) Commercial Off-the-Shelf Products in Defense Applications.

2001-01-01

346

YUCCA MOUNTAIN SITE CHARACTERIZATIONS PROJECT TUNNEL BORING MACHINE (TBM) SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate hazards related to the tunnel boring machine (TBM) used in the Exploratory Studies Facility (ESF) at the Yucca Mountain Site Characterization Project. This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. Since the TBM is an ''as built'' system, the M&O is conducting the System Safety Analysis during the construction or assembly phase of the TBM. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the TBM in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the system/subsystem/component design, (2) add safety features and capabilities to existing designs, and (3) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions. The scope of this analysis is limited to the TBM during normal operations, excluding hazards occurring during assembly and test of the TBM or maintenance of the TBM equipment.

N /A

1997-02-19

347

YUCCA MOUNTAIN SITE CHARACTERIZATION PROJECT EAST-WEST DRIFT SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate hazards related to the design of the Yucca Mountain Project Exploratory Studies Facility (ESF) East-West Cross Drift. This analysis builds upon prior ESF System Safety Analyses and incorporates TS Main Drift scenarios, where applicable, into the East-West Drift scenarios. This System Safety Analysis (SSA) focuses on the personnel safety and health hazards associated with the engineered design of the East-West Drift. The analysis also evaluates other aspects of the East-West Drift, including purchased equipment (e.g., scientific mapping platform) or Systems/Structures/Components (SSCs) and out-of-tolerance conditions. In addition to recommending design mitigation features, the analysis identifies the potential need for procedures, training, or Job Safety Analyses (JSAs). The inclusion of this information in the SSA is intended to assist the organization(s) (e.g., constructor, Safety and Health, design) responsible for these aspects of the East-West Drift in evaluating personnel hazards and augment the information developed by these organizations. The SSA is an integral part of the systems engineering process, whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach is used which incorporates operating experiences and recommendations from vendors, the constructor and the operating contractor. The risk assessment in this analysis characterizes the scenarios associated with East-West Drift SSCs in terms of relative risk and includes recommendations for mitigating all identified hazards. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into SSC designs. (2) Add safety features and capabilities to existing designs. (3) Develop procedures and conduct training to increase worker awareness of potential hazards, reduce exposure to hazards, and inform personnel of the actions required to avoid accidents or correct hazardous conditions. This analysis does not consider temporary construction items and, therefore, does not consider hazards associated with temporary construction items. This analysis will be reviewed and updated to reflect new East-West Drift design changes, construction modifications, and ''as built'' documentation of the East-West Drift when completed. A major difference between this analysis and previous ESF SSAs is the inclusion of hazards that arise as a result of non-accident events, (e.g., ''off-normal'' operations, adverse environmental conditions, or ''out-of-tolerance'' conditions). Non-accident events, that were not included in previous ESF SSAs, include environmental and/or toxic hazards such as leaking gases/fluids, off-gassing reactions, and excessive dust, particulates, exhaust fumes, noise, temperature, etc. which could have an adverse health effect on personnel.

NA

1999-06-08

348

Fuzzy-algebra uncertainty analysis for abnormal-environment safety assessment  

SciTech Connect

Many safety (risk) analyses depend on uncertain inputs and on mathematical models chosen from various alternatives, but give fixed results (implying no uncertainty). Conventional uncertainty analyses help, but are also based on assumptions and models, the accuracy of which may be difficult to assure. Some of the models and assumptions that on cursory examination seem reasonable can be misleading. As a result, quantitative assessments, even those accompanied by uncertainty measures, can give unwarranted impressions of accuracy. Since analysis results can be a major contributor to a safety-measure decision process, risk management depends on relating uncertainty to only the information available. The uncertainties due to abnormal environments are even more challenging than those in normal-environment safety assessments, and therefore require an even more cautious approach. A fuzzy algebra analysis is proposed in this report that has the potential to appropriately reflect the information available and portray uncertainties well, especially for abnormal environments.

Cooper, J.A.

1994-01-01

349

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2013 CFR

...ensures that the margin is satisfied over 95% of the antenna radiation sphere surrounding the launch vehicle. (3) When demonstrating...launch hold time. For a launch vehicle that uses any solid propellant, the analysis must demonstrate that the battery...

2013-01-01

350

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2014 CFR

...ensures that the margin is satisfied over 95% of the antenna radiation sphere surrounding the launch vehicle. (3) When demonstrating...launch hold time. For a launch vehicle that uses any solid propellant, the analysis must demonstrate that the battery...

2014-01-01

351

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2012 CFR

...demonstrates that the system satisfies the fault tolerance requirements of § 417.303...demonstrates that the system satisfies the fault tolerance requirements of section D417...standard industry methodology such as a fault tree analysis or a failure modes...

2012-01-01

352

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2011 CFR

...demonstrates that the system satisfies the fault tolerance requirements of § 417.303...demonstrates that the system satisfies the fault tolerance requirements of section D417...standard industry methodology such as a fault tree analysis or a failure modes...

2011-01-01

353

ARIES-ACT1 SAFETY DESIGN AND ANALYSIS  

SciTech Connect

ARIES-ACT1 is a 1000 MWe tokamak design featuring advanced physics and engineering. Some relevant features include an advanced SiC blanket with PbLi as coolant and breeder, a helium cooled steel structural ring and tungsten divertors, a thin-walled, helium cooled vacuum vessel, and a room temperature water-cooled shield outside the vacuum vessel. We consider here some safety aspects of the ARIES-ACT1 design, and model a series of design-basis and beyond design-basis accidents with MELCOR. The presence of multiple coolants (PbLi, helium, and water) makes possible a variety of such accidents. We consider here a loss of flow accident (i.e. long term station blackout), an ex-vessel helium break into the cryostat, and a beyond design-basis accident in which both loss of power and a loss of the water coolant occur. In all cases we find that secondary confinement boundaries are not challenged, and the structural integrity of in-vessel components is not threatened by high temperatures; decay heat can be safely removed in all cases by passive systems.

Paul W. Humrickhouse; Brad J. Merrill

2015-01-01

354

Safety, tolerability and risk benefit analysis of tiotropium in COPD  

PubMed Central

COPD is a chronic disease and, like many other chronic diseases, there is no treatment to reverse the severity of the disease except for lung transplant. To date, no inhaled medications have been shown to improve survival. Tiotropium bromide is a long-acting inhaled anticholinergic drug for the treatment of COPD that can improve lung function, reduce symptoms and exacerbations, and improve quality of life with once-daily dosing. It was initially approved and marketed in several countries in Europe in 2002 and then approved in the US in 2004. Tiotropium is generally well tolerated with dry mouth being the main adverse effect. Other adverse effects include constipation, tachycardia, blurred vision, urinary retention and increased intraocular pressure. Despite the recently raised concerns about an excess risk of cardiovascular adverse events with inhaled anticholinergic agents, the risk/benefit ratio of tiotropium appears still favorable given the favorable safety profile demonstrated in the UPLIFT study. However, caution should be advised in patients at high risk for cardiovascular disease given the paucity of data in such patients. PMID:19281075

Oba, Yuji; Zaza, Tareq; Thameem, Danish M

2008-01-01

355

Safety of railway control systems: A new Preliminary risk analysis approach  

Microsoft Academic Search

Preliminary risk analysis (PRA) is a methodology used in critical systems safety studies. It is primarily used at the preliminary stage of the system¿s design so as to determine the scenarios of potential accidents, to evaluate their probabilities of occurrence (frequency) as well as the severity of the resulting consequences and to propose solutions (preventive and\\/or mitigative safeguards) in order

F. Guenab; J. L. Boulanger; W. Schon

2008-01-01

356

Preliminary Accident Analysis for Construction and Operation of the Chornobyl New Safety Confinement  

SciTech Connect

Analysis of potential exposure of personal and population during construction and exploitation of the New Safe Confinement was made. Scenarios of hazard event development were ranked. It is shown, that as a whole construction and exploitation of the NSC are in accordance with actual radiation safety norms of Ukraine.

Batiy, Valeriy; Rubezhansky, Yruiy; Rudko, Vladimir; shcherbin, vladimir; Yegorov, V; Schmieman, Eric A.; Timmins, Douglas C.

2005-08-08

357

NSAC: in-depth look at Three Mile Island. [Nuclear Safety Analysis Center, EPRI headquarters  

Microsoft Academic Search

The Nuclear Safety Analysis Center (NSAC) is hoping to learn what caused the reactor accident at Three Mile Island, what happened during the accident, and how to take advantage of what is learned to prevent future incidents. When the Electric Power Research Institute (EPRI) was asked to make an independent assessment, the NSAC was organized with a separate identity and

N. Lihach; E. Zebroski

1979-01-01

358

NASA/TM-2009-215768 A Mathematical Basis for the Safety Analysis of  

E-print Network

June 2009 NASA/TM-2009-215768 A Mathematical Basis for the Safety Analysis of Conflict Prevention, Virginia Gilles Dowek Ecole Polytechnique, France #12;NASA STI Program . . . in Profile Since its founding, NASA has been dedicated to the advancement of aeronautics and space science. The NASA scientific

Maddalon, Jeffrey M.

359

NASA/TM-2007-214856 Safety and Performance Analysis of the  

E-print Network

March 2007 NASA/TM-2007-214856 Safety and Performance Analysis of the Non-Radar Oceanic National Institute of Aerospace, Hampton, Virginia #12;The NASA STI Program Office . . . in Profile Since its founding, NASA has been dedicated to the advancement of aeronautics and space science. The NASA

Muñoz, César A.

360

SAFETY ANALYSIS ON RAIL HIGHWAY AT-GRADE CROSSING IN ALABAMA  

E-print Network

SAFETY ANALYSIS ON RAIL HIGHWAY AT-GRADE CROSSING IN ALABAMA Jing Li, Post-doc Researcher Gaurav-lane divided highways, urban/suburban arterials, highway bridges, and rail highway at-grade crossings, based Alabama Total Highway-Rail Incidents 1980 2012 82% reduction 70% reduction What can make RHGCs safer

Illinois at Urbana-Champaign, University of

361

Dynamic fault tree analysis using Monte Carlo simulation in probabilistic safety assessment  

Microsoft Academic Search

Traditional fault tree (FT) analysis is widely used for reliability and safety assessment of complex and critical engineering systems. The behavior of components of complex systems and their interactions such as sequence- and functional-dependent failures, spares and dynamic redundancy management, and priority of failure events cannot be adequately captured by traditional FTs. Dynamic fault tree (DFT) extend traditional FT by

K. Durga Rao; V. Gopika; V. V. S. Sanyasi Rao; H. S. Kushwaha; A. K. Verma; A. Srividya

2009-01-01

362

Quantitative and Qualitative Analysis of Nutrition and Food Safety Information in School Science Textbooks of India  

ERIC Educational Resources Information Center

Objective: To assess quantity and quality of nutrition and food safety information in science textbooks prescribed by the Central Board of Secondary Education (CBSE), India for grades I through X. Design: Content analysis. Methods: A coding scheme was developed for quantitative and qualitative analyses. Two investigators independently coded the…

Subba Rao, G. M.; Vijayapushapm, T.; Venkaiah, K.; Pavarala, V.

2012-01-01

363

Aircraft Autolander Safety Analysis Through Optimal Control-Based Reach Set Computation  

Microsoft Academic Search

and safety analysis of autoland systems. It is shown to be applicable to specific phases of landing: descent, flare, and touchdown. The method is based on optimal control and level set methods; it simultaneously computes a maximal controlled invariant set and a set-valued control law guaranteed to keep the aircraft within a safe set of states under autopilot mode switching.

Alexandre M. Bayen; Claire J. Tomlin; Meeko M. K. Oishi

2007-01-01

364

The Range Safety Debris Catalog Analysis in Preparation for the Pad Abort One Flight Test  

NASA Technical Reports Server (NTRS)

With each flight test a Range Safety Data Package is assembled to understand the potential consequences of various failure scenarios. Debris catalog analysis considers an overpressure failure of the Abort Motor and the resulting debris field created 1. Characterize debris fragments generated by failure: weight, shape, and area 2. Compute fragment ballistic coefficients 3. Compute fragment ejection velocities.

Kutty, Prasad; Pratt, William

2010-01-01

365

Safety analysis of first 1000 patients treated with magnetic sphincter augmentation for gastroesophageal reflux disease.  

PubMed

Antireflux surgery with a magnetic sphincter augmentation device (MSAD) restores the competency of the lower esophageal sphincter with a device rather than a tissue fundoplication. As a regulated device, safety information from the published clinical literature can be supplemented by tracking under the Safe Medical Devices Act. The aim of this study was to examine the safety profile of the MSAD in the first 1000 implanted patients. We compiled safety data from all available sources as of July 1, 2013. The analysis included intra/perioperative complications, hospital readmissions, procedure-related interventions, reoperations, and device malfunctions leading to injury or inability to complete the procedure. Over 1000 patients worldwide have been implanted with the MSAD at 82 institutions with median implant duration of 274 days. Event rates were 0.1% intra/perioperative complications, 1.3% hospital readmissions, 5.6% endoscopic dilations, and 3.4% reoperations. All reoperations were performed non-emergently for device removal, with no complications or conversion to laparotomy. The primary reason for device removal was dysphagia. No device migrations or malfunctions were reported. Erosion of the device occurred in one patient (0.1%). The safety analysis of the first 1000 patients treated with MSAD for gastroesophageal reflux disease confirms the safety of this device and the implantation technique. The overall event rates were low based on data from 82 institutions. The MSAD is a safe therapeutic option for patients with chronic, uncomplicated gastroesophageal reflux disease. PMID:24612509

Lipham, J C; Taiganides, P A; Louie, B E; Ganz, R A; DeMeester, T R

2015-05-01

366

Parent Ratings of ADHD Symptoms: Generalized Partial Credit Model Analysis of Differential Item Functioning across Gender  

ERIC Educational Resources Information Center

Objective: Generalized partial credit model, which is based on item response theory (IRT), was used to test differential item functioning (DIF) for the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.), inattention (IA), and hyperactivity/impulsivity (HI) symptoms across boys and girls. Method: To accomplish this, parents completed…

Gomez, Rapson

2012-01-01

367

Anatomical structural network analysis of human brain using partial correlations of gray matter volumes  

Microsoft Academic Search

Structural connectivity in human brain has been studied by modeling the statistical dependence between features of cortical regions, such as gray matter thickness. Statistical correlations between gray matter thickness have been mainly used as a metric to study this dependence. In this paper, we propose the use of partial correlations instead of Pearson correlation for inferring the brain structural connectivity

Anand A. Joshi; Shantanu H. Joshi; Ivo D. Dinov; David W. Shattuck; Richard M. Leahy; Arthur W. Toga

2010-01-01

368

Long-term analysis of telescopic crown retained removable partial dentures: Survival and need for maintenance  

Microsoft Academic Search

ObjectivesThe aim of this retrospective longitudinal study was to evaluate the clinical long-term survival of telescopic crown retained removable partial dentures (TRPDs), the influencing factors on survival as well as the type and number of necessary treatments during the observation time.

Bernd Wöstmann; Markus Balkenhol; Andrea Weber; Paul Ferger; Peter Rehmann

2007-01-01

369

Comparative Analysis of Laparoscopic Versus Open Partial Nephrectomy for Renal Tumors in 200 Patients  

Microsoft Academic Search

PurposeLaparoscopic partial nephrectomy is an emerging minimally invasive, nephron sparing approach for renal cell carcinoma. We compared perioperative outcomes after laparoscopic and open nephron sparing surgery (NSS) for patients with a solitary renal tumor of 7 cm or less at a single institution.

INDERBIR S. GILL; SURENA F. MATIN; MIHIR M. DESAI; JIHAD H. KAOUK; ANDREW STEINBERG; E. D. MASCHA; JULIE THORNTON; MAHMOUD H. SHERIEF; BRENDA STRZEMPKOWSKI; ANDREW C. NOVICK

2003-01-01

370

Classification of the Genus Mobiluncus Based on Comparative Partial 16s rRNA Gene Analysis  

Microsoft Academic Search

On the basis of partial 16s rRNA gene sequences and the results of Southern blot analyses, we confirmed the division of the genus Mobiluncus into the species Mobiluncus curtisii and Mobiluncus mulieris. Division of M. curtisii into M. curtisii subsp. curtisii and M. curtisii subsp. hulmesii was not supported by our data. Spiegel and Roberts (15) proposed that the genus

A. TIVELJUNG; U. FORSUM; H.-J. MONSTEIN

1996-01-01

371

Synteny analysis of loci controlling partial resistance to Aphanomyces euteiches between Pisum sativum and Medicago truncatula  

Technology Transfer Automated Retrieval System (TEKTRAN)

Aphanomyces root rot, due to Aphanomyces euteiches, is one of the most damaging diseases of pea worldwide. Breeding for partial polygenic resistance to Aphanomyces root rot is a major objective for the development of the pea crop in Europe. Our objectives were to study i)- the diversity of resistanc...

372

Quantification of Antioxidants in Polyethylene by Near Infrared (NIR) Analysis and Partial Least Squares (PLS) Regression  

Microsoft Academic Search

Partial least squares (PLS) regression was used to generate a calibration model that can be used for the prediction of the content of two antioxidants, Irganox 1010 and Irgafos 168, in high density polyethylene (HDPE). The samples containing levels of either one or both antioxidants in a range of 0-4500 ppm were analyzed by near infrared (NIR) in the diffuse

Walker Camacho; Sigbritt Karlsson

2002-01-01

373

Analysis of an adaptive control scheme for a partially observed controlled Markov chain  

Microsoft Academic Search

The authors consider an adaptive finite state controlled Markov chain with partial state information, motivated by a class of replacement problems. They present parameter estimation techniques based on the information available after actions that reset the state to a known value are taken. It is proved that the parameter estimates converge w.p.1 to the true (unknown) parameter, under the feedback

Emmanuel Fernandez-Gaucherand; Aristotle Arapostathis; Steven I. Marcus

1993-01-01

374

Viscoelastic finite element analysis of an all-ceramic fixed partial denture  

Microsoft Academic Search

In recent years metal-free ceramic systems have become increasingly popular in dental practice because of their superior aesthetics, chemical durability and biocompatibility. Recently, manufacturers have proposed new dental ceramic systems that are advertized as being suitable for posterior fixed partial dentures (FPDs). Reports indicate that some of these systems have exhibited poor clinical performance. The objective of this study was

Paul H. DeHoff; Kenneth J. Anusavice; Nils Götzen

2006-01-01

375

Cost/benefit analysis of managing annual invasive grasses in partially invaded sagebrush steppe ecosystems  

Technology Transfer Automated Retrieval System (TEKTRAN)

Our objective was to evaluate the cost-benefit of a single herbicide application or targeted grazing of annual grasses during restoration of partially invaded sagebrush steppe ecosystems used for livestock production. The cost/benefit model used is based on estimating the production of vegetation i...

376

Linking Socioeconomic Status to Social Cognitive Career Theory Factors: A Partial Least Squares Path Modeling Analysis  

ERIC Educational Resources Information Center

The purpose of this study was to investigate the contributions of socioeconomic status (SES) in predicting social cognitive career theory (SCCT) factors. Data were collected from 738 college students in Taiwan. The results of the partial least squares (PLS) analyses indicated that SES significantly predicted career decision self-efficacy (CDSE);…

Huang, Jie-Tsuen; Hsieh, Hui-Hsien

2011-01-01

377

Transmission line arrester energy, cost, and risk of failure analysis for partially shielded transmission lines  

Microsoft Academic Search

Application of metal oxide surge arresters in power systems has been traditionally linked to electrical equipment protection. The industry has noted a very significant increase in the application of metal oxide arresters on transmission lines in an effort to reduce lightning initiated flashovers. This paper describes a cost-effective installation of surge arresters on a partially shielded transmission line. It compares

Eva J. Tarasiewicz; Finn Rimmer; Atef S. Morched

2000-01-01

378

SYSTEMS SAFETY ANALYSIS FOR FIRE EVENTS ASSOCIATED WITH THE ECRB CROSS DRIFT  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate fire hazards related to the Yucca Mountain Site Characterization Project (YMP) Enhanced Characterization of the Repository Block (ECRB) East-West Cross Drift (commonly referred to as the ECRB Cross-Drift). This analysis builds upon prior Exploratory Studies Facility (ESF) System Safety Analyses and incorporates Topopah Springs (TS) Main Drift fire scenarios and ECRB Cross-Drift fire scenarios. Accident scenarios involving the fires in the Main Drift and the ECRB Cross-Drift were previously evaluated in ''Topopah Springs Main Drift System Safety Analysis'' (CRWMS M&O 1995) and the ''Yucca Mountain Site Characterization Project East-West Drift System Safety Analysis'' (CRWMS M&O 1998). In addition to listing required mitigation/control features, this analysis identifies the potential need for procedures and training as part of defense-in-depth mitigation/control features. The inclusion of this information in the System Safety Analysis (SSA) is intended to assist the organization(s) (e.g., Construction, Environmental Safety and Health, Design) responsible for these aspects of the ECRB Cross-Drift in developing mitigation/control features for fire events, including Emergency Refuge Station(s). This SSA was prepared, in part, in response to Condition/Issue Identification and Reporting/Resolution System (CIRS) item 1966. The SSA is an integral part of the systems engineering process, whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach is used which incorporates operating experiences and recommendations from vendors, the constructor and the operating contractor. The risk assessment in this analysis characterizes the scenarios associated with fires in terms of relative risk and includes recommendations for mitigating all identified hazards. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into Structure, System, or Component (SSC) designs; (2) Add safety features and capabilities to existing designs; and (3) Develop procedures and conduct training to increase worker awareness of potential hazards, reduce exposure to hazards, and inform personnel of the actions required to avoid accidents or correct hazardous conditions.

R. J. Garrett

2001-12-12

379

Stress analysis of portable safety platform (Core Sampler Truck)  

SciTech Connect

This document provides the stress analysis and evaluation of the portable platform of the rotary mode core sampler truck No. 2 (RMCST {number_sign}2). The platform comprises railing, posts, deck, legs, and a portable ladder; it is restrained from lateral motion by means of two brackets added to the drill-head service platform.

Ziada, H.H.

1995-03-30

380

10 CFR 830.204 - Documented safety analysis.  

Code of Federal Regulations, 2011 CFR

...category 1, 2, or 3 DOE nuclear facility must obtain...category 1, 2, or 3 DOE nuclear facility must, as...normal, abnormal, and accident conditions, including...need for analysis of accidents which may be beyond...respect to a nonreactor nuclear facility with...

2011-01-01

381

10 CFR 830.204 - Documented safety analysis.  

Code of Federal Regulations, 2013 CFR

...category 1, 2, or 3 DOE nuclear facility must obtain...category 1, 2, or 3 DOE nuclear facility must, as...normal, abnormal, and accident conditions, including...need for analysis of accidents which may be beyond...respect to a nonreactor nuclear facility with...

2013-01-01

382

10 CFR 830.204 - Documented safety analysis.  

Code of Federal Regulations, 2012 CFR

...category 1, 2, or 3 DOE nuclear facility must obtain...category 1, 2, or 3 DOE nuclear facility must, as...normal, abnormal, and accident conditions, including...need for analysis of accidents which may be beyond...respect to a nonreactor nuclear facility with...

2012-01-01

383

10 CFR 830.204 - Documented safety analysis.  

Code of Federal Regulations, 2014 CFR

...category 1, 2, or 3 DOE nuclear facility must obtain...category 1, 2, or 3 DOE nuclear facility must, as...normal, abnormal, and accident conditions, including...need for analysis of accidents which may be beyond...respect to a nonreactor nuclear facility with...

2014-01-01

384

UML-BASED DESIGN AND FORMAL ANALYSIS OF A SAFETY CRITICAL RAILWAY CONTROL SOFTWARE MODULE  

Microsoft Academic Search

A new equipment of safety relevance has been developed to upgrade ageing relay-based railway interlocking systems in Hungary. In course of the design process formal methods have been used in the development of a module realising a well-separable function of the system. Namely, the UML-based design process was extended by model based analysis and validation. The first kind of analysis

András Pataricza; István Majzik; Gábor Huszerl; György Várnai

385

Safety of atorvastatin derived from analysis of 44 completed trials in 9,416 patients  

Microsoft Academic Search

This analysis assessed the safety of atorvastatin in the 10- to 80-mg dose range using pooled data from 44 completed trials comprising 16,495 dyslipidemic patients treated with atorvastatin (n = 9,416), placebo (n = 1,789), and other statins (n = 5,290). A retrospective analysis was conducted and included treatment-associated adverse events, serious adverse events, and musculoskeletal and hepatic adverse events.

Connie B Newman; Gary Palmer; Halit Silbershatz; Michael Szarek

2003-01-01

386

Toxicological and clinical computational analysis by the Informatics and Computational Safety Analysis Staff of the US FDA\\/CDER  

Microsoft Academic Search

The Informatics and Computational Safety Analysis Staff at US FDA\\/CDER has established a consortium of collaborators who are engaged in harvesting data from FDA archives and creating QSAR models of animal toxicological and human health effect endpoints. Databases of animal toxicology studies and human clinical trial and surveillance data have been compiled and the non-proprietary portions are being made publicly

Daniel R. Benz; Edwin J. Matthews; Naomi L. Kruhlak; Anna A. Frid; Barbara L. Minnier; Joseph F. Contrera

387

Advances in coupled safety modeling using systems analysis and high-fidelity methods.  

SciTech Connect

The potential for a sodium-cooled fast reactor to survive severe accident initiators with no damage has been demonstrated through whole-plant testing in EBR-II and FFTF. Analysis of the observed natural protective mechanisms suggests that they would be characteristic of a broad range of sodium-cooled fast reactors utilizing metal fuel. However, in order to demonstrate the degree to which new, advanced sodium-cooled fast reactor designs will possess these desired safety features, accurate, high-fidelity, whole-plant dynamics safety simulations will be required. One of the objectives of the advanced safety-modeling component of the Reactor IPSC is to develop a science-based advanced safety simulation capability by utilizing existing safety simulation tools coupled with emerging high-fidelity modeling capabilities in a multi-resolution approach. As part of this integration, an existing whole-plant systems analysis code has been coupled with a high-fidelity computational fluid dynamics code to assess the impact of high-fidelity simulations on safety-related performance. With the coupled capabilities, it is possible to identify critical safety-related phenomenon in advanced reactor designs that cannot be resolved with existing tools. In this report, the impact of coupling is demonstrated by evaluating the conditions of outlet plenum thermal stratification during a protected loss of flow transient. Outlet plenum stratification was anticipated to alter core temperatures and flows predicted during natural circulation conditions. This effect was observed during the simulations. What was not anticipated, however, is the far-reaching impact that resolving thermal stratification has on the whole plant. The high temperatures predicted at the IHX inlet due to thermal stratification in the outlet plenum forces heat into the intermediate system to the point that it eventually becomes a source of heat for the primary system. The results also suggest that flow stagnation in the intermediate system is possible, raising questions about the effectiveness of the intermediate decay heat removal systems in the design that was evaluated. Existing tools do not predict flow stagnation. This work has demonstrated that with a proper coupling approach, a high-fidelity CFD tool can be used to resolve the important flow and temperature distributions throughout a plant while still maintaining the whole-plant safety analysis capabilities of a systems analysis code.

Fanning, T. H.; Thomas, J. W.; Nuclear Engineering Division

2010-05-31

388

Improvement and verification of fast reactor safety analysis techniques  

Microsoft Academic Search

An initial analysis of the KIWI-TNT experiment using the VENUS-II ;\\u000a disassembly code has been completed. The calculated fission energy release ;\\u000a agreed with the experimental value to within about 3 percent. An initial model ;\\u000a for analyzing the SNAPTRAN-2 core disassembly experiment was also developed along ;\\u000a with an appropriate equation-of-state. The first phase of the VENUS-II\\/PAD ;\\u000a comparison

1975-01-01

389

Top-Off Safety Analysis for NSLS-II  

SciTech Connect

Top-off injection will be adopted in NSLS-II. To ensure no injected beam can pass into experimental beamlines with open photon shutters during top-off injection, simulation studies for possible machine fault scenarios are required. We compare two available simulation methods, backward (H. Nishimura-LBL) and forward tracking (A. Terebilo-SLAC). We also discuss the tracking settings, fault scenarios, apertures and interlocks considered in the analysis.

Li,Y.; Casey, B.; Heese, R.; Hseuh, H.; Job, O.; Krinsky, S.; Parker, B.; Shaftan, T.; Sharma, S.

2009-05-04

390

Final safety analysis report for the Ground Test Accelerator (GTA), Phase 2  

SciTech Connect

This document is the second volume of a 3 volume safety analysis report on the Ground Test Accelerator (GTA). The GTA program at the Los Alamos National Laboratory (LANL) is the major element of the national Neutral Particle Beam (NPB) program, which is supported by the Strategic Defense Initiative Office (SDIO). A principal goal of the national NPB program is to assess the feasibility of using hydrogen and deuterium neutral particle beams outside the Earth`s atmosphere. The main effort of the NPB program at Los Alamos concentrates on developing the GTA. The GTA is classified as a low-hazard facility, except for the cryogenic-cooling system, which is classified as a moderate-hazard facility. This volume consists of failure modes and effects analysis; accident analysis; operational safety requirements; quality assurance program; ES&H management program; environmental, safety, and health systems critical to safety; summary of waste-management program; environmental monitoring program; facility expansion, decontamination, and decommissioning; summary of emergency response plan; summary plan for employee training; summary plan for operating procedures; glossary; and appendices A and B.

NONE

1994-10-01

391

Functional and structural analysis of partial optic nerve avulsion due to blunt trauma: Case report  

PubMed Central

Partial optic nerve avulsion (ONA) secondary to finger gouging is an uncommon but devastating injury. A 21-year-old man who had an acute vision loss after accidentally getting poked by himself in his right eye when he fell down during jogging is reported. The patient was diagnosed with partial ONA. Magnetic resonance imaging revealed intact optic nerve. Optical coherence tomography (OCT) revealed deep cavity at the inferior-temporal half of the optic disc. Retinal nerve fiber layer thickness was also thin at the inferior quadrant with circumpapillary OCT scan. Visual field test and electrophysiological tests showed functional abnormality compatible with optic nerve lesion. Diagnostic tools for anatomical and functional evaluation may reveal the course of this injury. PMID:20952839

Mumcuoglu, Tarkan; Durukan, Hakan A; Erdurman, Cuneyt; Hurmeric, Volkan; Gundogan, Fatih C

2010-01-01

392

Renormalization shielding and eikonal analysis on the atomic collision in dense partially ionized hydrogen plasmas  

SciTech Connect

The renormalization plasma screening effects on the electron-ion collision are investigated in dense partially ionized hydrogen plasmas. The Hamilton-Jacobi and eikonal methods with the effective interaction potential are employed to obtain the eikonal scattering phase shift and eikonal cross section for the electron-ion collision. It is found that the influence of renormalization screening strongly suppresses the eikonal scattering phase shift as well as the eikonal cross section, especially, for small impact parameter regions. In addition, the renormalization screening effect reduces the total eikonal cross section in all energy domains. The variation of the renormalization effects on the electron-ion collision in dense partially ionized hydrogen plasmas is also discussed.

Kim, Sung Soo [Department of Applied Mathematics, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of)] [Department of Applied Mathematics, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of); Jung, Young-Dae [Department of Applied Physics and Department of Bionanotechnology, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of) [Department of Applied Physics and Department of Bionanotechnology, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of); Department of Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, New York 12180-3590 (United States)

2013-12-15

393

Experimental analysis of the levees safety based on geophysical monitoring  

NASA Astrophysics Data System (ADS)

Several flood events brought river levees into the focus of attention for some disasters due to their collapse. This phenomena is quite complex to investigate, because of different factors that can affect the stability of levees, among them the non uniformity of material properties, which influencing the permeability of the embankment, might induce high percolation velocity of flux thus triggering the unstability. Thus, to apply a fast and integrate investigation methods with a non-destructive characteristics should have a large interest, if they are able to furnish ready and usable information necessary to hydrogeological models. In order to achieve this goal, the University of Perugia (Department of Civil and Environmental Engineering) and the National Research Council (IRPI and IMAA research institutes) developed a collaborating project on the study of the internal structure of the river embankment by carrying out experiments in laboratory. The purpose of this study is to show the preliminary results of the experimental investigation. The laboratory embankment was built using material coming from a real levee and gathered inside a 1.5m x 1.2m plexiglas box. The box has two compartments: a water reservoir at one hand where a constant water head was reached after some time and a soil simulating the presence of levee. We perform a geoelectrical multichannel acquisition system with three parallel profiles characterized by 16 mini-electrodes connected to georesistivimeter Syscal Pro. An automatic acquisition protocol has been performed to obtain time slice electrical tomographies during the experiments. The geophysical results show the effect of the water table inside the embankment during the wetting and emptying. In order to assess the capability of the geophysical monitoring for addressing the soil parameters estimate, the resistivity results are investigated by using two analytical and one hydraulic numerical models. The analytical models represent a linear solution of Laplace's equation where Dupuit hypothesis holds (the vertical gradients of the flow velocity in the medium are neglected). In particular, the Marchi and Supino solutions are investigated here by assuming the upstream water level variations in the river negligible with respect to the ones inside the groundwater under the steady state condition. Two different seepage fronts are calculated and compared with the ones inferred from the resistivity maps. The experimental data have been also compared with the results computed by a numerical code. The governing equation for the unsaturated-saturated medium is the continuity equation written in terms of the piezometric head unknown while the Brooks-Corey law relates the water content and the relative hydraulic conductivity to the piezometric head. The numerical model is a time splitting technique and the solution is obtained by solving consecutively a convective and a diffusive component. The medium has been discretized in space using a generally unstructured triangular mesh. The governing equations are discretized using the edge centred mixed hybrid finite element scheme. The computational domain is schematized as 1D network of cells located at the middle point of each edge and linked by fictitious channels and the storage capacity is concentrated in the cells. A linear variation of unknown is assumed inside each triangle. The positive outcomes of hydraulic model application have certainly had benefit from the information coming from the geophysical monitoring. Based on these preliminary results it was noticeable as the geophysical monitoring can be conveniently adopted for addressing the levee safety control and to provide information on soil parameters.

Rizzo, Enzo; Valeria, Giampaolo; Mario, Votta; Lapenna, Vincenzo; Moramarco, Tommaso; Aricò, Costanza; Camici, S.; Morbidelli, Renato; Sinagra, M.; Tucciarelli, T.

2010-05-01

394

Receiving Basin for Offsite Fuels and the Resin Regeneration Facility Safety Analysis Report, Executive Summary  

SciTech Connect

The Safety Analysis Report documents the safety authorization basis for the Receiving Basin for Offsite Fuels (RBOF) and the Resin Regeneration Facility (RRF) at the Savannah River Site (SRS). The present mission of the RBOF and RRF is to continue in providing a facility for the safe receipt, storage, handling, and shipping of spent nuclear fuel assemblies from power and research reactors in the United States, fuel from SRS and other Department of Energy (DOE) reactors, and foreign research reactors fuel, in support of the nonproliferation policy. The RBOF and RRF provide the capability to handle, separate, and transfer wastes generated from nuclear fuel element storage. The DOE and Westinghouse Savannah River Company, the prime operating contractor, are committed to managing these activities in such a manner that the health and safety of the offsite general public, the site worker, the facility worker, and the environment are protected.

Shedrow, C.B.

1999-11-29

395

Waste Tank Organic Safety Project: Analysis of liquid samples from Hanford waste tank 241-C-103  

SciTech Connect

A suite of physical and chemical analyses has been performed in support of activities directed toward the resolution of an Unreviewed Safety Question concerning the potential for a floating organic layer in Hanford waste tank 241-C-103 to sustain a pool fire. The analysis program was the result of a Data Quality Objectives exercise conducted jointly with staff from Westinghouse Hanford Company and Pacific Northwest Laboratory (PNL). The organic layer has been analyzed for flash point, organic composition including volatile organics, inorganic anions and cations, radionuclides, and other physical and chemical parameters needed for a safety assessment leading to the resolution of the Unreviewed Safety Question. The aqueous layer underlying the floating organic material was also analyzed for inorganic, organic, and radionuclide composition, as well as other physical and chemical properties. This work was conducted to PNL Quality Assurance impact level III standards (Good Laboratory Practices).

Pool, K.H.; Bean, R.M.

1994-03-01

396

Partial wave analysis of J\\/psi-->gamma(pi+pi- pi+pi-)  

Microsoft Academic Search

BES data on J\\/psi-->gamma(pi+pi- pi+pi-) have been analyzed into partial waves. We fit with resonances having JPC=2++ at 1275 MeV, 0++ at 1500 MeV, 2++ at 1565 MeV, 0++ at 1740 MeV, 2++ at 1940 MeV and 0++ at 2104 MeV, plus a broad 0- component. The 0++ resonances decay dominantly to \\/sigmasigma, while 2++ resonances in the high mass

J. Z. Bai; Y. Ban; J. G. Bian; A. D. Chen; G. P. Chen; H. F. Chen; H. S. Chen; J. C. Chen; X. D. Chen; Y. Chen; B. S. Cheng; X. Z. Cui; H. L. Ding; L. Y. Dong; Z. Z. Du; C. S. Gao; M. L. Gao; S. Q. Gao; J. H. Gu; S. D. Gu; W. X. Gu; Y. N. Guo; Z. J. Guo; S. W. Han; Y. Han; J. He; K. L. He; M. He; Y. K. Heng; G. Y. Hu; H. M. Hu; J. L. Hu; Q. H. Hu; T. Hu; G. S. Huang; X. P. Huang; Y. Z. Huang; C. H. Jiang; Y. Jin; X. Ju; Z. J. Ke; Y. F. Lai; P. F. Lang; C. G. Li; D. Li; H. B. Li; J. Li; P. Q. Li; W. Li; X. H. Li; X. N. Li; X. Q. Li; Z. C. Li; B. Liu; F. Liu; H. M. Liu; J. Liu; R. G. Liu; Y. Liu; Z. X. Liu; G. R. Lu; F. Lu; J. G. Lu; X. L. Luo; E. C. Ma; J. M. Ma; H. S. Mao; Z. P. Mao; X. C. Meng; X. H. Mo; J. Nie; N. D. Qi; X. R. Qi; C. D. Qian; J. F. Qiu; Y. H. Qu; Y. K. Que; G. Rong; Y. Y. Shao; B. W. Shen; D. L. Shen; H. Shen; X. Y. Shen; F. Shi; H. Z. Shi; X. F. Song; H. S. Sun; L. F. Sun; Y. Z. Sun; S. Q. Tang; G. L. Tong; F. Wang; L. Wang; L. Z. Wang; P. Wang; S. M. Wang; Y. Y. Wang; Z. Y. Wang; C. L. Wei; N. Wu; Y. G. Wu; D. M. Xi; X. M. Xia; Y. H. Xie; G. F. Xu; S. T. Xue; J. Yan; W. G. Yan; C. M. Yang; C. Y. Yang; H. X. Yang; X. F. Yang; M. H. Ye; S. W. Ye; Y. X. Ye; C. S. Yu; C. X. Yu; G. W. Yu; Y. H. Yu; Z. Q. Yu; C. Z. Yuan; Y. Yuan; B. Y. Zhang; C. Zhang; D. H. Zhang; H. L. Zhang; J. Zhang; L. Zhang; P. Zhang; Q. J. Zhang; S. Q. Zhang; X. Y. Zhang; Y. Y. Zhang; D. X. Zhao; H. W. Zhao; J. Zhao; M. Zhao; W. R. Zhao; Z. G. Zhao; J. P. Zheng; L. S. Zheng; Z. P. Zheng; B. Q. Zhou; L. Zhou; K. J. Zhu; Q. M. Zhu; Y. C. Zhu; Y. S. Zhu; Z. A. Zhu; B. A. Zhuang; D. V. Bugg; B. S. Zou; I. Scott

2000-01-01

397

Generalized Partial-Element Equivalent-Circuit Analysis for Planar Circuits With Slotted Ground  

Microsoft Academic Search

A generalized partial-element equivalent-circuit (PEEC) method is proposed for modeling a planar circuit with a thin narrow slot on the ground. The approach is based on the coupled mixed potential integral equations for a problem with mixed electric and magnetic currents. The coupled integral equations are converted into a lumped-element circuit network using Kirchhoff's voltage law and Kirchhoff's current law

Kai Yang; Ke-Li Wu

2009-01-01

398

Sequence analysis of the partial spike glycoprotein gene of porcine epidemic diarrhea viruses isolated in Korea  

Microsoft Academic Search

Porcine epidemic diarrhea virus (PEDV) causes a devastating enteric disease with acute diarrhea, dehydration and significant\\u000a mortality in swine, thereby incurring heavy economic losses in Korea. Spike (S) glycoprotein has been suggested as an important\\u000a determinant for PEDV biological properties. In this study, the nucleotide and deduced amino acid sequences of the partial\\u000a S glycoprotein genes of Korean PEDV isolates,

Seong-Jun Park; Hyoung-Joon Moon; Jeong-Sun Yang; Chul-Seung Lee; Dae-Sub Song; Bo-Kyu Kang; Bong-Kyun Park

2007-01-01

399

Cold collisions in strong laser fields: partial wave analysis of magnesium collisions  

Microsoft Academic Search

.  \\u000a We have developed Monte Carlo wave function simulation schemes to study\\u000a cold collisions between magnesium atoms in a strong red-detuned laser field.\\u000a In order to address the strong-field problem, we extend the Monte Carlo wave function framework to include the partial wave\\u000a structure of the three-dimensional system. The average heating rate due to radiative collisions is calculated with two

J. Piilo; E. Lundh; K.-A. Suominen

2006-01-01

400

Developing a Comprehensive Software Suite for Advanced Reactor Performance and Safety Analysis  

SciTech Connect

This paper provides an introduction to the reactor analysis capabilities of the nuclear power reactor simulation tools that are being developed as part of the U.S. Department of Energy s Nuclear Energy Advanced Modeling and Simulation (NEAMS) Toolkit. The NEAMS Toolkit is an integrated suite of multi-physics simulation tools that leverage high-performance computing to reduce uncertainty in the prediction of performance and safety of advanced reactor and fuel designs. The Toolkit effort is comprised of two major components, the Fuels Product Line (FPL), which provides tools for fuel performance analysis, and the Reactor Product Line (RPL), which provides tools for reactor performance and safety analysis. This paper provides an overview of the NEAMS RPL development effort.

Pointer, William David [ORNL] [ORNL; Bradley, Keith S [ORNL] [ORNL; Fischer, Paul F [ORNL] [ORNL; Smith, Micheal A [ORNL] [ORNL; Tautges, Timothy J [ORNL] [ORNL; Ferencz, Robert M [ORNL] [ORNL; Martineau, Richard C [ORNL] [ORNL; Jain, Rajeev [ORNL] [ORNL; Obabko, Aleksandr [Argonne National Laboratory (ANL)] [Argonne National Laboratory (ANL); Billings, Jay Jay [ORNL] [ORNL

2013-01-01

401

An object-oriented approach to risk and reliability analysis : methodology and aviation safety applications.  

SciTech Connect

This article describes how features of event tree analysis and Monte Carlo-based discrete event simulation can be combined with concepts from object-oriented analysis to develop a new risk assessment methodology, with some of the best features of each. The resultant object-based event scenario tree (OBEST) methodology enables an analyst to rapidly construct realistic models for scenarios for which an a priori discovery of event ordering is either cumbersome or impossible. Each scenario produced by OBEST is automatically associated with a likelihood estimate because probabilistic branching is integral to the object model definition. The OBEST methodology is then applied to an aviation safety problem that considers mechanisms by which an aircraft might become involved in a runway incursion incident. The resulting OBEST model demonstrates how a close link between human reliability analysis and probabilistic risk assessment methods can provide important insights into aviation safety phenomenology.

Dandini, Vincent John; Duran, Felicia Angelica; Wyss, Gregory Dane

2003-09-01

402

Yucca Mountain Site Charecterization Project Design Package 1C System Safety Analysis  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate hazards related to the Yucca Mountain Project Exploratory Studies Facility (ESF) Design Package IC, Surface Utilities (for a list of package 1C subsystems see section 3). This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the Design Package 1C structures/systems/components in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the structure/system/component (S/S/C) design, (2) add safety devices and capabilities to the designs that reduce risk, (3) provide devices that detect and warn personnel of hazardous conditions, and (4) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions. The scope of this analysis is limited to the Design Package 1C structures/systems/components (S/S/Cs) during normal operations. Hazards occurring during maintenance and ''off normal'' operations have not been included in this analysis.

TRW

1995-10-16

403

Improvement of three-field based safety analysis code, SPACE, through verification and validation  

SciTech Connect

To verify and validate the state-of-the-art safety analysis code, SPACE, features of three field governing equations were arranged and the comparative analysis with both analytic solution and experimental benchmarks were performed. With the world wide streamline on the safety analysis, SPACE uses two-fluid, three-field governing equations which aim to implement multi-dimensional and multi-scaled analysis. Through the Verification and Validation (V and V), developing code based on the three-field governing equation have not only been confirmed but also improved. V and V activities on SPACE have been conducted as to interfacial drag model in vertical turbulent flow. The verification of the interfacial drag model was based on cell size sensitivity test for confirming feasible calculation range of cell size. Furthermore, through the validation with analytic solution, the modification of the interfacial drag model in vertical turbulent annulus flow was carried out and the nominated model was incorporated. Modified interfacial drag model, Asali's correlation, yields improved result than previous interfacial drag model. The validation with experimental benchmarks had also been performed on the nearly horizontal counter current limitation. To confirm the possibility of the further application of the CCFL model in case with horizontal pipe, validation with nearly horizontal pipe experiment was carried out. V and V activities of SPACE with analytic solution and experimental benchmarks allow us to confirm/identify the tailorability for safety analysis. (authors)

Yang, J. H.; Kim, J. H.; Park, G. C. [Nuclear Thermal-Hydraulic Engineering Laboratory, Seoul National Univ., Gwanak-599 Gwanak-ro, Gwanak-gu, Seoul 151-742 (Korea, Republic of)

2012-07-01

404

Static Analysis Tools, a Practical Approach for Safety-Critical Software Verification  

NASA Astrophysics Data System (ADS)

Static code analysis tools available today range from Lintbased syntax parsers to standards' compliance checkers to tools using more formal methods for verification. As safety critical software complexity is increasing, these tools provide a mean to ensure code quality, safety and dependability attributes. They also provide a mean to introduce further automation in code analysis activities. The features presented by static code analysis tools are particularly interesting for V&V activities. In the scope of Independent Code Verification (IVE), two different static analysis tools have been used during Code Verification activities of the LISA Pathfinder onboard software in order to assess their contribution to the efficiency of the process and quality of the results. Polyspace (The MathWorks) and FlexeLint (Gimpel) tools have been used as examples of high-budget and low-budget tools respectively. Several aspects have been addressed: effort has been categorised for closer analysis (e.g. setup and configuration time, execution time, analysis of the results, etc), reported issues have been categorised according to their type and the coverage of traditional IVE tasks by the static code analysis tools has been evaluated. Final observations have been performed by analysing the previously referred subjects, namely regarding cost effectiveness, quality of results, complementarities between the results of different static code analysis tools and relation between automated code analysis and manual code inspection.

Lopes, R.; Vicente, D.; Silva, N.

2009-05-01

405

Organizational analysis and safety for utilities with nuclear power plants: perspectives for organizational assessment. Volume 2. [PWR; BWR  

SciTech Connect

This two-volume report presents the results of initial research on the feasibility of applying organizational factors in nuclear power plant (NPP) safety assessment. Volume 1 of this report contains an overview of the literature, a discussion of available safety indicators, and a series of recommendations for more systematically incorporating organizational analysis into investigations of nuclear power plant safety. The six chapters of this volume discuss the major elements in our general approach to safety in the nuclear industry. The chapters include information on organizational design and safety; organizational governance; utility environment and safety related outcomes; assessments by selected federal agencies; review of data sources in the nuclear power industry; and existing safety indicators.

Osborn, R.N.; Olson, J.; Sommers, P.E.; McLaughlin, S.D.; Jackson, M.S.; Nadel, M.V.; Scott, W.G.; Connor, P.E.; Kerwin, N.; Kennedy, J.K. Jr.

1983-08-01

406

Design and Transient Analysis of Passive Safety Cooling Systems for Advanced Nuclear Reactors  

NASA Astrophysics Data System (ADS)

The Pebble Bed Advanced High Temperature Reactor (PB-AHTR) is a pebble fueled, liquid salt cooled, high temperature nuclear reactor design that can be used for electricity generation or other applications requiring the availability of heat at elevated temperatures. A stage in the design evolution of this plant requires the analysis of the plant during a variety of potential transients to understand the primary and safety cooling system response. This study focuses on the performance of the passive safety cooling system with a dual purpose, to assess the capacity to maintain the core at safe temperatures and to assist the design process of this system to achieve this objective. The analysis requires the use of complex computational tools for simulation and verification using analytical solutions and comparisons with experimental data. This investigation builds upon previous detailed design work for the PB-AHTR components, including the core, reactivity control mechanisms and the intermediate heat exchanger, developed in 2008. In addition the study of this reference plant design employs a wealth of auxiliary information including thermal-hydraulic physical phenomena correlations for multiple geometries and thermophysical properties for the constituents of the plant. Finally, the set of performance requirements and limitations imposed from physical constrains and safety considerations provide with a criteria and metrics for acceptability of the design. The passive safety cooling system concept is turned into a detailed design as a result from this study. A methodology for the design of air-cooled passive safety systems was developed and a transient analysis of the plant, evaluating a scrammed loss of forced cooling event was performed. Furthermore, a design optimization study of the passive safety system and an approach for the validation and verification of the analysis is presented. This study demonstrates that the resulting point design responds properly to the transient event and maintains the core and reactor components at acceptable temperatures within allowable safety margins. It is also demonstrated that the transition from steady full-power, forced-cooling mode to steady decay-heat, natural-circulation mode is stable, predictable and well characterized.

Galvez, Cristhian

2011-12-01

407

MODEL 9977 B(M)F-96 SAFETY ANALYSIS REPORT FOR PACKAGING  

SciTech Connect

This Safety Analysis Report for Packaging (SARP) documents the analysis and testing performed on and for the 9977 Shipping Package, referred to as the General Purpose Fissile Package (GPFP). The performance evaluation presented in this SARP documents the compliance of the 9977 package with the regulatory safety requirements for Type B packages. Per 10 CFR 71.59, for the 9977 packages evaluated in this SARP, the value of ''N'' is 50, and the Transport Index based on nuclear criticality control is 1.0. The 9977 package is designed with a high degree of single containment. The 9977 complies with 10 CFR 71 (2002), Department of Energy (DOE) Order 460.1B, DOE Order 460.2, and 10 CFR 20 (2003) for As Low As Reasonably Achievable (ALARA) principles. The 9977 also satisfies the requirements of the Regulations for the Safe Transport of Radioactive Material--1996 Edition (Revised)--Requirements. IAEA Safety Standards, Safety Series No. TS-R-1 (ST-1, Rev.), International Atomic Energy Agency, Vienna, Austria (2000). The 9977 package is designed, analyzed and fabricated in accordance with Section III of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel (B&PV) Code, 1992 edition.

Abramczyk, G; Paul Blanton, P; Kurt Eberl, K

2006-05-18

408

Final safety analysis report for the Galileo Mission. Volume 1: Reference design document  

NASA Astrophysics Data System (ADS)

The Galileo mission uses nuclear power sources called Radioisotope Thermoelectric Generators (RTGs) to provide the spacecraft's primary electrical power. Because these generators contain nuclear material, a Safety Analysis Report (SAR) is required. A preliminary SAR and an updated SAR were previously issued that provided an evolving status report on the safety analysis. As a result of the Challenger accident, the launch dates for both Galileo and Ulysses missions were later rescheduled for November 1989 and October 1990, respectively. The decision was made by agreement between the DOE and the NASA to have a revised safety evaluation and report (FSAR) prepared on the basis of these revised vehicle accidents and environments. The results of this latest revised safety evaluation are presented in this document (Galileo FSAR). Volume 1, this document, provides the background design information required to understand the analyses presented in Volumes 2 and 3. It contains descriptions of the RTGs, the Galileo spacecraft, the Space Shuttle, the Inertial Upper Stage (IUS), the trajectory and flight characteristics including flight contingency modes, and the launch site. There are two appendices in Volume 1 which provide detailed material properties for the RTG.

1988-05-01

409

Final safety analysis report for the Galileo Mission: Volume 1, Reference design document  

SciTech Connect

The Galileo mission uses nuclear power sources called Radioisotope Thermoelectric Generators (RTGs) to provide the spacecraft's primary electrical power. Because these generators contain nuclear material, a Safety Analysis Report (SAR) is required. A preliminary SAR and an updated SAR were previously issued that provided an evolving status report on the safety analysis. As a result of the Challenger accident, the launch dates for both Galileo and Ulysses missions were later rescheduled for November 1989 and October 1990, respectively. The decision was made by agreement between the DOE and the NASA to have a revised safety evaluation and report (FSAR) prepared on the basis of these revised vehicle accidents and environments. The results of this latest revised safety evaluation are presented in this document (Galileo FSAR). Volume I, this document, provides the background design information required to understand the analyses presented in Volumes II and III. It contains descriptions of the RTGs, the Galileo spacecraft, the Space Shuttle, the Inertial Upper Stage (IUS), the trajectory and flight characteristics including flight contingency modes, and the launch site. There are two appendices in Volume I which provide detailed material properties for the RTG.

Not Available

1988-05-01

410

Documentation of Hanford Site independent review of the Hanford Waste Vitrification Plant Preliminary Safety Analysis Report. Revision 3  

SciTech Connect

Westinghouse Hanford Company (WHC) is the Integrating Contractor for the Hanford Waste Vitrification Plant (HWVP) Project, and as such is responsible for preparation of the HWVP Preliminary Safety Analysis Report (PSAR). The HWVP PSAR was prepared pursuant to the requirements for safety analyses contained in US Department of Energy (DOE) Orders 4700.1, Project Management System (DOE 1987); 5480.5, Safety of Nuclear Facilities (DOE 1986a); 5481.lB, Safety Analysis and Review System (DOE 1986b) which was superseded by DOE order 5480-23, Nuclear Safety Analysis Reports, for nuclear facilities effective April 30, 1992 (DOE 1992); and 6430.lA, General Design Criteria (DOE 1989). The WHC procedures that, in large part, implement these DOE requirements are contained in WHC-CM-4-46, Nonreactor Facility Safety Analysis Manual. This manual describes the overall WHC safety analysis process in terms of requirements for safety analyses, responsibilities of the various contributing organizations, and required reviews and approvals.

Herborn, D.I.

1993-11-01

411

The Range Safety Debris Catalog Analysis in Preparation for the Pad Abort One Flight Test  

NASA Technical Reports Server (NTRS)

The Pad Abort One flight test of the Orion Abort Flight Test Program is currently under development with the goal of demonstrating the capability of the Launch Abort System. In the event of a launch failure, this system will propel the Crew Exploration Vehicle to safety. An essential component of this flight test is range safety, which ensures the security of range assets and personnel. A debris catalog analysis was done as part of a range safety data package delivered to the White Sands Missile Range in New Mexico where the test will be conducted. The analysis discusses the consequences of an overpressurization of the Abort Motor. The resulting structural failure was assumed to create a debris field of vehicle fragments that could potentially pose a hazard to the range. A statistical model was used to assemble the debris catalog of potential propellant fragments. Then, a thermodynamic, energy balance model was applied to the system in order to determine the imparted velocity to these propellant fragments. This analysis was conducted at four points along the flight trajectory to better understand the failure consequences over the entire flight. The methods used to perform this analysis are outlined in detail and the corresponding results are presented and discussed.

Kutty, Prasad M.; Pratt, William D.

2010-01-01

412

Uncertainty analysis for multivariate state estimation in safety-critical and mission-critical maintenance applications  

SciTech Connect

The Multivariate State Estimation Technique (MSET) has been developed at Argonne National Laboratory (ANL) and applied for real time surveillance applications for the purposes of signal validation, sensor operability validation, equipment health monitoring, incipient component fault annunciation, and process anomaly identification. Although MSET was originally developed for applications in the commercial nuclear industry, it has recently been spun off for applications in fields such as aerospace, manufacturing, transportation, robotics, and ship propulsion. Notwithstanding these types of successful applications of MSET in industry, it is necessary for safety-critical and mission-critical applications of MSET to have reliability analysis methods, including a propagation-of-uncertainty tool, which is needed to support safety evaluations in a variety of industries, and technical-specification-change requests in the case of the nuclear industry. For these and related applications, a general purpose uncertainty analysis tool for MSET has been developed that uses Monte Carlo simulation with Latin Hypercube Sampling. For any new application of MSET, the uncertainty analysis tool developed here may be used to investigate quantitative propagation-of-uncertainty behavior for all sensors under surveillance. In addition to supporting safety analysis of surveillance systems that are based on MSET, the tool developed here can be employed in parametric studies to support system designers in evaluating the relative value of adding new sensors to an engineering system during early design stages or for equipment or facility upgrades.

Zavaljevski, N.; Gross, K. C.

2000-04-03

413

Costs and benefits of automotive fuel economy improvement: A partial analysis  

SciTech Connect

This paper is an exercise in estimating the costs and benefits of technology-based fuel economy improvements for automobiles and light trucks. Benefits quantified include vehicle cots, fuel savings, consumer`s surplus effects, the effect of reduced weight on vehicle safety, impacts on emissions of CO{sub 2} and criteria pollutants, world oil market and energy security benefits, and the transfer of wealth from US consumes to oil producers. A vehicle stock model is used to capture sales, scrappage, and vehicle use effects under three fuel price scenarios. Three alternative fuel economy levels for 2001 are considered, ranging from 32.9 to 36.5 MPG for cars and 24.2 to 27.5 MPG for light trucks. Fuel economy improvements of this size are probably cost-effective. The size of the benefit, and whether there is a benefit, strongly depends on the financial costs of fuel economy improvement and judgments about the values of energy security, emissions, safety, etc. Three sets of values for eight parameters are used to define the sensitivity of costs and benefits to key assumptions. The net present social value (1989$) of costs and benefits ranges from a cost of $11 billion to a benefit of $286 billion. The critical parameters being the discount rate (10% vs. 3%) and the values attached to externalities. The two largest components are always the direct vehicle costs and fuel savings, but these tend to counterbalance each other for the fuel economy levels examined here. Other components are the wealth transfer, oil cost savings, CO{sub 2} emissions reductions, and energy security benefits. Safety impacts, emissions of criteria pollutants, and consumer`s surplus effects are relatively minor components. The critical issues for automotive fuel economy are therefore: (1) the value of present versus future costs and benefits, (2) the values of external costs and benefits, and (3) the financially cost-effective level of MPG achievable by available technology. 53 refs.

Greene, D.L. [Oak Ridge National Lab., TN (United States); Duleep, K.G. [Energy and Environmental Analysis, Inc., Arlington, VA (United States)

1992-03-01

414

Costs and benefits of automotive fuel economy improvement: A partial analysis  

SciTech Connect

This paper is an exercise in estimating the costs and benefits of technology-based fuel economy improvements for automobiles and light trucks. Benefits quantified include vehicle cots, fuel savings, consumer's surplus effects, the effect of reduced weight on vehicle safety, impacts on emissions of CO{sub 2} and criteria pollutants, world oil market and energy security benefits, and the transfer of wealth from US consumes to oil producers. A vehicle stock model is used to capture sales, scrappage, and vehicle use effects under three fuel price scenarios. Three alternative fuel economy levels for 2001 are considered, ranging from 32.9 to 36.5 MPG for cars and 24.2 to 27.5 MPG for light trucks. Fuel economy improvements of this size are probably cost-effective. The size of the benefit, and whether there is a benefit, strongly depends on the financial costs of fuel economy improvement and judgments about the values of energy security, emissions, safety, etc. Three sets of values for eight parameters are used to define the sensitivity of costs and benefits to key assumptions. The net present social value (1989$) of costs and benefits ranges from a cost of $11 billion to a benefit of $286 billion. The critical parameters being the discount rate (10% vs. 3%) and the values attached to externalities. The two largest components are always the direct vehicle costs and fuel savings, but these tend to counterbalance each other for the fuel economy levels examined here. Other components are the wealth transfer, oil cost savings, CO{sub 2} emissions reductions, and energy security benefits. Safety impacts, emissions of criteria pollutants, and consumer's surplus effects are relatively minor components. The critical issues for automotive fuel economy are therefore: (1) the value of present versus future costs and benefits, (2) the values of external costs and benefits, and (3) the financially cost-effective level of MPG achievable by available technology. 53 refs.

Greene, D.L. (Oak Ridge National Lab., TN (United States)); Duleep, K.G. (Energy and Environmental Analysis, Inc., Arlington, VA (United States))

1992-03-01

415

On a nonlinear partial differential algebraic system arising in technical textile industry: Analysis and numerics  

E-print Network

In this paper a length-conserving numerical scheme for a nonlinear fourth order system of partial differential algebraic equations arising in technical textile industry is studied. Applying a semidiscretization in time, the resulting sequence of nonlinear elliptic systems with algebraic constraint is reformulated as constrained optimization problems in a Hilbert space setting that admit a solution at each time level. Stability and convergence of the scheme are proved. The numerical realization is performed by projected gradient methods on finite element spaces which determine the computational effort and approximation quality of the algorithm. Simulation results are presented and discussed in view of the application of an elastic inextensible fiber motion.

Grothaus, Martin

2012-01-01

416

Supplement to safety analysis report for the 325 Radiochemistry Building  

SciTech Connect

The Waste Preparation Task (Task 6) of the Commercial Nuclear Waste Vitrification Project (CNWVP) includes the design, installation and operation of small scale (1 MTU LWR fuel/month) equipment to prepare high-level liquid waste (HLLW) from commercial LWR spent fuel. The HLLW will be used in Task 5, the radioactive demonstration of waste vitrification. The operational aspects of this task include the procurement of irradiated LWR fuel; the processing operations to prepare HLLW; and other necessary operations associated with the disposition of the uranium waste and other fuel residues, including the plutonium associated with the fuel. The processing operations in the 325-A Building will require handling in excess of 45 percent of a Minimum Critical Mass (MCM), use of an organic solvent to extract uranium and plutonium away from the fission products, and ion exchange resin for plutonium purification. An analysis of the environmental consequences and probability of conceivable accidental conditions that may result from this operation indicates no undue consequences to the environment. The calculated maximum environmental consequences of postulated accidents would be low radiotoxic doses of 0.3 rem whole body 50-yr dose commitment to a maximum individual and 20 man-rem whole body 50-yr dose commitment to the surrounding population. The individual radiological exposures are much below the permissible exposure guidance levels in 10CFR100 of 25 rem whole body and 300 rem thyroid doses for nuclear reactor accidents of very low probability of occurrence. The calculated relative dose risk to individuals from accidental conditions (1.6 x 10/sup -6/ rem/yr) is very low compared to regulatory guidance for routine releases from nuclear reactors (5.0 x 10/sup -3/ rem/yr). Therefore, the design and operational plans for the CNWVP are judged not to represent an undue environmental risk from accidental conditions.

Bryan, G.H.; Wittenbrock, N.G.

1977-06-24

417

Estimating multiparameter partial expected value of perfect information from a probabilistic sensitivity analysis sample: a nonparametric regression approach.  

PubMed

The partial expected value of perfect information (EVPI) quantifies the expected benefit of learning the values of uncertain parameters in a decision model. Partial EVPI is commonly estimated via a 2-level Monte Carlo procedure in which parameters of interest are sampled in an outer loop, and then conditional on these, the remaining parameters are sampled in an inner loop. This is computationally demanding and may be difficult if correlation between input parameters results in conditional distributions that are hard to sample from. We describe a novel nonparametric regression-based method for estimating partial EVPI that requires only the probabilistic sensitivity analysis sample (i.e., the set of samples drawn from the joint distribution of the parameters and the corresponding net benefits). The method is applicable in a model of any complexity and with any specification of input parameter distribution. We describe the implementation of the method via 2 nonparametric regression modeling approaches, the Generalized Additive Model and the Gaussian process. We demonstrate in 2 case studies the superior efficiency of the regression method over the 2-level Monte Carlo method. R code is made available to implement the method. PMID:24246566

Strong, Mark; Oakley, Jeremy E; Brennan, Alan

2014-04-01

418

The Vanishing Moment Method for Fully Nonlinear Second Order Partial Differential Equations: Formulation, Theory, and Numerical Analysis  

E-print Network

The vanishing moment method was introduced by the authors in [37] as a reliable methodology for computing viscosity solutions of fully nonlinear second order partial differential equations (PDEs), in particular, using Galerkin-type numerical methods such as finite element methods, spectral methods, and discontinuous Galerkin methods, a task which has not been practicable in the past. The crux of the vanishing moment method is the simple idea of approximating a fully nonlinear second order PDE by a family (parametrized by a small parameter $\\vepsi$) of quasilinear higher order (in particular, fourth order) PDEs. The primary objectives of this book are to present a detailed convergent analysis for the method in the radial symmetric case and to carry out a comprehensive finite element numerical analysis for the vanishing moment equations (i.e., the regularized fourth order PDEs). Abstract methodological and convergence analysis frameworks of conforming finite element methods and mixed finite element methods are ...

Feng, Xiaobing

2011-01-01

419

On the Partial-Wave Analysis of Mesonic Resonances Decaying to Multiparticle Final States Produced by Polarized Photons  

SciTech Connect

Meson spectroscopy is going through a revival with the advent of high statistics experiments and new advances in the theoretical predictions. The Constituent Quark Model (CQM) is finally being expanded considering more basic principles of field theory and using discrete calculations of Quantum Chromodynamics (lattice QCD). These new calculations are approaching predictive power for the spectrum of hadronic resonances and decay modes. It will be the task of the new experiments to extract the meson spectrum from the data and compare with those predictions. The goal of this report is to describe one particular technique for extracting resonance information from multiparticle final states. The technique described here, partial wave analysis based on the helicity formalism, has been used at Brookhaven National Laboratory (BNL) using pion beams, and Jefferson Laboratory (Jlab) using photon beams. In particular this report broaden this technique to include production experiments using linearly polarized real photons or quasi-real photons. This article is of a didactical nature. We describe the process of analysis, detailing assumptions and formalisms, and is directed towards people interested in starting partial wave analysis.

Salgado, Carlos W. [Norfolk State University, Norfolk, VA (United States) and Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Weygand, Dennis P. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

2014-04-01

420

On the partial-wave analysis of mesonic resonances decaying to multiparticle final states produced by polarized photons  

NASA Astrophysics Data System (ADS)

Meson spectroscopy is going through a revival with the advent of high statistics experiments and new advances in the theoretical predictions. The Constituent Quark Model (CQM) is finally being expanded considering more basic principles of field theory and using discrete calculations of Quantum Chromodynamics (lattice QCD). These new calculations are approaching predictive power for the spectrum of hadronic resonances and decay modes. It will be the task of the new experiments to extract the meson spectrum from the data and compare with those predictions. The goal of this report is to describe one particular technique for extracting resonance information from multiparticle final states. The technique described here, partial wave analysis based on the helicity formalism, has been used at Brookhaven National Laboratory (BNL) using pion beams, and Jefferson Laboratory (JLab) using photon beams. In particular this report broadens this technique to include production experiments using linearly polarized real photons or quasi-real photons. This article is of a didactical nature. We describe the process of analysis, detailing assumptions and formalisms, and is directed towards people interested in starting partial wave analysis.

Salgado, Carlos W.; Weygand, Dennis P.

2014-04-01

421

Partial least-squares-discriminant analysis differentiating Chinese wolfberries by UPLC-MS and flow injection mass spectrometric (FIMS) fingerprints.  

PubMed

Lycium barbarum L. fruits (Chinese wolfberries) were differentiated for their cultivation locations and the cultivars by ultraperformance liquid chromatography coupled with mass spectrometry (UPLC-MS) and flow injection mass spectrometric (FIMS) fingerprinting techniques combined with chemometrics analyses. The partial least-squares-discriminant analysis (PLS-DA) was applied to the data projection and supervised learning with validation. The samples formed clusters in the projected data. The prediction accuracies by PLS-DA with bootstrapped Latin partition validation were greater than 90% for all models. The chemical profiles of Chinese wolfberries were also obtained. The differentiation techniques might be utilized for Chinese wolfberry authentication. PMID:25152955

Lu, Weiying; Jiang, Qianqian; Shi, Haiming; Niu, Yuge; Gao, Boyan; Yu, Liangli Lucy

2014-09-17

422

Electronic Nose Based on Independent Component Analysis Combined with Partial Least Squares and Artificial Neural Networks for Wine Prediction  

PubMed Central

The aim of this work is to propose an alternative way for wine classification and prediction based on an electronic nose (e-nose) combined with Independent Component Analysis (ICA) as a dimensionality reduction technique, Partial Least Squares (PLS) to predict sensorial descriptors and Artificial Neural Networks (ANNs) for classification purpose. A total of 26 wines from different regions, varieties and elaboration processes have been analyzed with an e-nose and tasted by a sensory panel. Successful results have been obtained in most cases for prediction and classification. PMID:22969387

Aguilera, Teodoro; Lozano, Jesús; Paredes, José A.; Álvarez, Fernando J.; Suárez, José I.

2012-01-01

423

Multivariate analysis of neuronal interactions in the generalized partial least squares framework: simulations and empirical studies  

Microsoft Academic Search

Identification of spatiotemporal interactions within\\/between neuron populations is critical for detection and characterization of large-scale neuronal interactions underlying perception, cognition, and behavior. Univariate analysis has been employed successfully in many neuroimaging studies. However, univariate analysis does not explicitly test for interactions between distributed areas of activity and is not sensitive to distributed responses across the brain. Multivariate analysis can explicitly

Fa-Hsuan Lin; Anthony R. McIntosh; John A. Agnew; Guinevere F. Eden; Thomas A. Zeffiro; John W. Belliveau

2003-01-01

424

A probabilistic safety analysis of UF{sub 6} handling at the Portsmouth Gaseous Diffusion Plant  

SciTech Connect

A probabilistic safety study of UF{sub 6} handling activities at the Portsmouth Gaseous Diffusion Plant has recently been completed. The analysis provides a unique perspective on the safety of UF{sub 6} handling activities. The estimated release frequencies provide an understanding of current risks, and the examination of individual contributors yields a ranking of important plant features and operations. Aside from the probabilistic results, however, there is an even more important benefit derived from a systematic modeling of all operations. The integrated approach employed in the analysis allows the interrelationships among the equipment and the required operations to be explored in depth. This paper summarizes the methods used in the study and provides an overview of some of the technical insights that were obtained. Specific areas of possible improvement in operations are described.

Boyd, G.J.; Lewis, S.R.; Summitt, R.L. [Safety and Reliability Optimization Services (SAROS), Inc., Knoxville, TN (United States)

1991-12-31

425

Safety analysis report for the Heavy-Element Facility (Building 251), Lawrence Livermore National Laboratory  

SciTech Connect

A comprehensive safety analysis was performed on the Lawrence Livermore National Laboratory's Heavy Element Facility, Building 251. The purpose of the analysis was to evaluate the building and its operations in order to inform LLNL and the Department of Energy of the risks they assume at Building 251. This was done by examining all of the energy sources and matching them with the physical and administrative barriers that control, prevent, or mitigate their hazards. Risk was evaluated for each source under both normal and catastrophic circumstances such as fire, flood, high wind, lighting, earthquake, and criticality. No significant safety deficiencies were found; it is concluded that the operation of the facility presents no unacceptable risk.

Kvam, D.J.

1982-10-11

426

Analysis of safety limits of the Moroccan TRIGA MARK II research reactor  

NASA Astrophysics Data System (ADS)

The main objective of this study is to check the ability of the Moroccan TRIGA MARK II research reactor, designed to use natural convection cooling, to operate at its nominal power (2 MW) with sufficient safety margins. The neutronic analysis of the core has been performed using Leopard and Mcrac codes and the parameters of interest were the power distributions, the power peaking factors and the core excess reactivity. The thermal hydraulic analysis of the TRIGA core was performed using the French code FLICA designed for transient and study state situations. The main safety related parameters of the core have been evaluated with special emphasises on the following: maximum fuel temperature, minimum DNBR and maximum void fraction. The obtained results confirm the designer predictions except for the void fraction.

Erradi, L.; Essadki, H.

2001-06-01

427

Architecture for Interlock Systems Reliability Analysis with Regard to Safety and Availability  

E-print Network

In the design of interlock loops for the signal exchange in machine protection systems, the choice of the hardware architecture impacts on machine safety and availability. The reliable performance of a machine stop (leaving the machine in a safe state) in case of an emergency, is an inherent requirement. The constraints in terms of machine availability on the other hand may differ from one facility to another. Spurious machine stops, lowering machine availability, may to a certain extent be tolerated in facilities where they do not cause undue equipment wearout. In order to compare various interlock loop architectures in terms of safety and availability, the occurrence frequencies of related scenarios have been calculated in a reliability analysis, using a generic analytical model. This paper presents the results and illustrates the potential of the analysis method for supporting the choice of interlock system architectures.

Wagner, S; Schmidt, R; Zerlauth, M; Vergara-Fernandez, A

2011-01-01

428

Integrated risk, uncertainty, and deterministic analysis of proposed safety upgrades to DOE hazardous facilities.  

SciTech Connect

DOE Authorization Basis evaluations and supporting documentation are required for facilities involving significant quantities of hazardous materials . A safety anal ysis of existing facilities typically includes lists of facility and process/procedure improvements that have the potential for improving safety. Unless the facility requires the upgrade to reduce significant risks to the public or to workers, the proposed modifications are subject to cost benefit analysis both to assess the worth of individual improvements and to assist with prioritizing improvements in the face of limited budgets . This paper describes the application of an integrated risk, uncertainty, and deterministic analysis approach for performing benefit/cost evaluations of proposed upgrades to the LANL Weapon Engineering Tritium Facility (WETF . )

Sciacca, F. W. (Frank W.); Konkel, H. (Herbert)

2003-01-01

429

Coupled Neutronics\\/Thermal-hydraulics Calculations for the Safety Analysis of the PBMR  

Microsoft Academic Search

This paper presents an overview of the safety analysis of the pebble-bed reactor using the advanced coupled-code NEM-THERMIX. This coupled code is a combination of the Nodal Expansion Method code (NEM), a 3-D neutronics code developed at Penn State, and THERMIX-DIREKT, a 2-D HTR thermal-hydraulics code. The coupled code is used in this work to illustrate the importance of coupled

Bismark Tyobeka; Kostadin Ivanov

430

Safety analysis report for packaging, onsite, long-length contaminated equipment transport system  

SciTech Connect

This safety analysis report for packaging describes the components of the long-length contaminated equipment (LLCE) transport system (TS) and provides the analyses, evaluations, and associated operational controls necessary for the safe use of the LLCE TS on the Hanford Site. The LLCE TS will provide a standardized, comprehensive approach for the disposal of approximately 98% of LLCE scheduled to be removed from the 200 Area waste tanks.

McCormick, W.A.

1997-05-09

431

The efficacy and safety of tubeless percutaneous nephrolithotomy: a systematic review and meta-analysis  

Microsoft Academic Search

The objective of this study was to conduct a systematic review and meta-analysis to evaluate the efficacy and safety of tubeless\\u000a versus standard percutaneous nephrolithotomy (PCNL). Relevant randomized or quasi-randomized controlled trials studies were\\u000a identified from electronic database (Cochrane CENTRAL, Medline and EMBASE et al.). The retrieval time ended in August 2010.\\u000a The quality of the included trials was assessed

Haichao Yuan; Shuo Zheng; Liangren Liu; Ping Han; Jia Wang; Qiang Wei

432

Structural analysis and safety assessment of submerged floating tunnel prototype in Qiandao Lake (China)  

Microsoft Academic Search

This article presents the structural analysis and the safety assessment of the submerged floating tunnel (SFT) prototype, which is designed to be built in Qiandao Lake (China). Based on the principle of bending stiffness equivalence, a homogenized equivalent single-layered-tube model is established. The effective beam bending stiffness and the corresponding Young’s modulus are deduced. By using lamination theory of composite

Shuangyin Zhang; Lei Wang; Youshi Hong

2010-01-01

433

The law and economics of administrative law: A statistical analysis of the Consumer Product Safety Commission's petition process  

Microsoft Academic Search

This study seeks to determine those factors influential in decision making at the Consumer Product Safety Commission, the primary federal agency charged with the regulation of unsafe consumer products. To make this determination, a statistical analysis was made of the Commission's petition process.^ Under the petition process, non-Commission personnel would request that the Commission promulgate a safety standard. The Commission

Thomas Boustead

1995-01-01

434

Preliminary Safety Analysis Report for the Transuranic Storage Area Retrieval Enclosure at the Idaho National Engineering Laboratory. Revision 8  

SciTech Connect

This Transuranic Storage Area Retrieval Enclosure Preliminary Safety Analysis Report was completed as required by DOE Order 5480.23. The purpose of this document is to construct a safety basis that supports the design and permits construction of the facility. The facility has been designed to the requirements of a Radioactive Solid Waste Facility presented in DOE Order 6430.1A.

Not Available

1993-03-01

435

Innovation vs Safety: Hazard Analysis Techniques to Avoid Premature Commitment during the Early Stage Development of National  

E-print Network

Innovation vs Safety: Hazard Analysis Techniques to Avoid Premature Commitment during the Early Stage Development of National Critical Infrastructures Chris W. Johnson, School of Computing Science safety concerns during the early stages of development. However, they often rely on scoping studies

Johnson, Chris

436

Guidance on risk analysis and safety implications of a large liquefied natural gas (LNG) spill over water  

Microsoft Academic Search

While recognized standards exist for the systematic safety analysis of potential spills or releases from LNG (Liquefied Natural Gas) storage terminals and facilities on land, no equivalent set of standards or guidance exists for the evaluation of the safety or consequences from LNG spills over water. Heightened security awareness and energy surety issues have increased industry's and the public's attention

Gerald William Wellman; Brian Matthew Melof; Anay Josephine Luketa-Hanlin; Marion Michael Hightower; John Morgan Covan; Louis Alan Gritzo; Michael James Irwin; Michael Jiro Kaneshige; Charles W. Morrow

2004-01-01

437

Quantitative analysis of cuneate neurone responsiveness in the cat in association with reversible, partial deafferentation.  

PubMed Central

1. Partial deafferentation, based on peripheral nerve section or local anaesthetic blockade, has been reported to induce both immediate loss of responsiveness and/or immediate reorganization in receptive fields of neurones in the somatosensory system. In the present study, in anaesthetized cats, we have used a rapid, reversible deafferentation procedure based on cold block of the median nerve in order to evaluate quantitatively the response characteristics of cuneate neurones (n = 39) before, during and after partial deafferentation. 2. The first hypothesis tested was that cuneate neurones with input from ulnar or superficial radial nerve fields in the vicinity of the median nerve field should undergo, in association with median nerve blockade, an increased level of responsiveness to tactile stimuli within the ulnar or radial nerve zone, and an expansion of their cutaneous receptive fields. However, among eighteen cuneate neurones of this type, there was no evidence for any systematic enhancement of responsiveness nor, in at least sixteen of the eighteen neurones, any evidence for receptive field expansion. 3. The second hypothesis tested was that cuneate neurones whose input came from both the median nerve and another peripheral nerve source should undergo, in association with median nerve blockade, an increase in responsiveness to the remaining input and an expansion of the receptive field into the field of that remaining nerve source. However, in none of thirteen neurones of this type tested was there evidence of such a change. 4. The third hypothesis was that cuneate neurones whose control' receptive fields were within the median nerve zone of deafferentation should show an emergence of novel receptive fields and responsiveness from areas around the field of innervation of the median nerve. However, in none of eight neurones of this type was there evidence for such changes in adjacent skin areas. 5. In conclusion, with the use of cold block of the median nerve for partial deafferentation, the present study has confirmed previous findings of denervation-related loss of responsiveness in dorsal column nuclei neurones. The conflicting findings in studies of central nervous system plasticity indicate the need to understand better factors that do and do not lead to acute central changes. Images Figure 4 Figure 5 PMID:9457651

Zhang, S P; Rowe, M J

1997-01-01

438

Statistical analysis of liquid seepage in partially saturated heterogeneous fracture systems  

SciTech Connect

Field evidence suggests that water flow in unsaturated fracture systems may occur along fast preferential flow paths. However, conventional macroscale continuum approaches generally predict the downward migration of water as a spatially uniform wetting front subjected to strong inhibition into the partially saturated rock matrix. One possible cause of this discrepancy may be the spatially random geometry of the fracture surfaces, and hence, the irregular fracture aperture. Therefore, a numerical model was developed in this study to investigate the effects of geometric features of natural rock fractures on liquid seepage and solute transport in 2-D planar fractures under isothermal, partially saturated conditions. The fractures were conceptualized as 2-D heterogeneous porous media that are characterized by their spatially correlated permeability fields. A statistical simulator, which uses a simulated annealing (SA) algorithm, was employed to generate synthetic permeability fields. Hypothesized geometric features that are expected to be relevant for seepage behavior, such as spatially correlated asperity contacts, were considered in the SA algorithm. Most importantly, a new perturbation mechanism for SA was developed in order to consider specifically the spatial correlation near conditioning asperity contacts. Numerical simulations of fluid flow and solute transport were then performed in these synthetic fractures by the flow simulator TOUGH2, assuming that the effects of matrix permeability, gas phase pressure, capillary/permeability hysteresis, and molecular diffusion can be neglected. Results of flow simulation showed that liquid seepage in partially saturated fractures is characterized by localized preferential flow, along with bypassing, funneling, and localized ponding. Seepage pattern is dominated by the fraction of asperity contracts, and their shape, size, and spatial correlation. However, the correlation structure of permeability field is less important than the spatial correlation of asperity contacts. A faster breakthrough was observed in fractures subjected to higher normal stress, accompanied with a nonlinearly decreasing trend of the effective permeability. Interestingly, seepage dispersion is generally higher in fractures with intermediate fraction of asperity contacts; but it is lower for small or large fractions of asperity contacts. However, it may become higher if the ponding becomes significant. Transport simulations indicate that tracers bypass dead-end pores and travel along flow paths that have less flow resistance. Accordingly, tracer breakthrough curves generally show more spreading than breakthrough curves for water. Further analyses suggest that the log-normal time model generally fails to fit the breakthrough curves for water, but it is a good approximation for breakthrough curves for the tracer.

Liou, T.S.

1999-12-01

439

Organizational analysis and safety for utilities with nuclear power plants: an organizational overview. Volume 1. [PWR; BWR  

SciTech Connect

This two-volume report presents the results of initial research on the feasibility of applying organizational factors in nuclear power plant (NPP) safety assessment. A model is introduced for the purposes of organizing the literature review and showing key relationships among identified organizational factors and nuclear power plant safety. Volume I of this report contains an overview of the literature, a discussion of available safety indicators, and a series of recommendations for more systematically incorporating organizational analysis into investigations of nuclear power plant safety.

Osborn, R.N.; Olson, J.; Sommers, P.E.; McLaughlin, S.D.; Jackson, M.S.; Scott, W.G.; Connor, P.E.

1983-08-01

440

Calculation of Scattering Amplitude Without Partial Analysis. II; Inclusion of Exchange  

NASA Technical Reports Server (NTRS)

There was a method for calculating the whole scattering amplitude, f(Omega(sub k)), directly. The idea was to calculate the complete wave function Psi numerically, and use it in an integral expression for f, which can be reduced to a 2 dimensional quadrature. The original application was for e-H scattering without exchange. There the Schrodinger reduces a 2-d partial differential equation (pde), which was solved using the finite element method (FEM). Here we extend the method to the exchange approximation. The S.E. can be reduced to a pair of coupled pde's, which are again solved by the FEM. The formal expression for f(Omega(sub k)) consists two integrals, f+/- = f(sub d) +/- f(sub e); f(sub d) is formally the same integral as the no-exchange f. We have also succeeded in reducing f(sub e) to a 2-d integral. Results will be presented at the meeting.

Temkin, Aaron; Shertzer, J.; Fisher, Richard R. (Technical Monitor)

2002-01-01

441

Non-Darcian forced convection analysis in an annulus partially filled with a porous material  

SciTech Connect

Numerical solutions are presented for fully developed forced convection in concentric annuli partially filled with a porous medium. The porous medium is attached at the inner cylinder, which is maintained at uniform heat flux or at uniform wall temperature while the outer cylinder is adiabatic. The Brinkman-Forchheimer-extended Darcy model was used to model the flow inside the porous medium. The dependence of the fluid flow and heat transfer on several parameters of the problem is thoroughly documented. The inertia coefficient at which the inertial effects reduce the flow rate by 5% is determined as a function of the Darcy number for various thicknesses of the porous substrate. It is also shown that a critical thickness at which the value of the Nusselt number reaches a minimum does not exist if the effective thermal conductivity of the fluid-saturated porous medium is much higher than the fluid conductivity.

Chikh, S.; Boumedien, A.; Bouhadef, K. [USTHB, Bab Ezzouar (Algeria). Inst. de Genie Mecanique; Lauriat, G. [CNAM, Paris (France). Lab. de Thermique

1995-12-01

442

Cold collisions in strong laser fields: partial wave analysis of magnesium collisions  

E-print Network

We have developed Monte Carlo wave function simulation schemes to study cold collisions between magnesium atoms in a strong red-detuned laser field. In order to address the strong-field problem, we extend the Monte Carlo wave function framework to include the partial wave structure of the three-dimensional system. The average heating rate due to radiative collisions is calculated with two different simulation schemes which are described in detail. We show that the results of the two methods agree and give estimates for the radiative collision heating rate for $^{24}$Mg atoms in a magneto-optical trap based on the $^1$S$_0$-