Note: This page contains sample records for the topic partial safety analysis from Science.gov.
While these samples are representative of the content of Science.gov,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of Science.gov
to obtain the most current and comprehensive results.
Last update: August 15, 2014.
1

Evaluation of Partial Safety Factors for Nuclear Piping System  

Microsoft Academic Search

This paper deals with evaluation of Partial Safety Factors for piping system in a nuclear power plant. LEFM failure criterion is considered for the analysis. Partial Safety Factors are evaluated for axial stress, bending stress, fracture toughness & flaw depth, considering the flaw depth as deterministic. In the next case, flaw depth is treated as a random variable and Partial

A. Srividya; Rohit Rastogi; K. Laxminarayana; Milind J. Sakhardande

2

Partial Safety Analysis for a Reduced Uranium Enrichment Core for the High Flux Isotope Reactor  

SciTech Connect

A computational model of the reactor core of the High Flux Isotope Rector (HFIR) was developed in order to analyze non-destructive accidents caused by transients during reactor operation. The reactor model was built for the latest version of the nuclear analysis software package called Program for the Analysis of Reactor Transients (PARET). Analyses performed with the model constructed were compared with previous data obtained with other tools in order to benchmark the code. Finally, the model was used to analyze the behavior of the reactor under transients using a different nuclear fuel with lower enrichment of uranium (LEU) than the fuel currently used, which has a high enrichment of uranium (HEU). The study shows that the presence of fertile isotopes in LEU fuel, which increases the neutron resonance absorption, reduces the impact of transients on the fuel and enhances the negative reactivity feedback, thus, within the limitations of this study, making LEU fuel appear to be a safe alternative fuel for the reactor core.

Primm, Trent [ORNL; Gehin, Jess C [ORNL

2009-04-01

3

Safety Analysis.  

National Technical Information Service (NTIS)

We are engaged in a research program in safety-critical computing that is based on two case studies. We use these case studies to provide application-specific details of the various research issues, and as targets for evaluation of research ideas. The fir...

1995-01-01

4

Safety analysis  

NASA Technical Reports Server (NTRS)

We are engaged in a research program in safety-critical computing that is based on two case studies. We use these case studies to provide application-specific details of the various research issues, and as targets for evaluation of research ideas. The first case study is the Magnetic Stereotaxis System (MSS), an investigational device for performing human neurosurgery being developed in a joint effort between the Department of Physics at the University of Virginia and the Department of Neurosurgery at the University of Iowa. The system operates by manipulating a small permanent magnet (known as a 'seed') within the brain using an externally applied magnetic field. By varying the magnitude and gradient of the external magnetic field, the seed can be moved along a non-linear path and positioned at a site requiring therapy, e.g., a tumor. The magnetic field required for movement through brain tissue is extremely high, and is generated by a set of six superconducting magnets located in a housing surrounding the patient's head. The system uses two X-ray cameras positioned at right angles to detect in real time the locations of the seed and of X-ray opaque markers affixed to the patient's skull. the X-ray images are used to locate the objects of interest in a canonical frame of reference. the second case study is the University of Virginia Research Nuclear Reactor (UVAR). It is a 2 MW thermal, concrete-walled pool reactor. The system operates using 20 to 25 plate-type fuel assemblies placed on a rectangular grid plate. There are three scramable safety rods, and one non-scramable regulating rod that can be put in automatic mode. It was originally constructed in 1959 as a 1 MW system, and it was upgraded to 2 MW in 1973. Though only a research reactor rather than a power reactor, the issues raised are significant and can be related to the problems faced by full-scale reactor systems.

Knight, John C.

1995-01-01

5

Finding safety in partially controllable chaotic systems  

NASA Astrophysics Data System (ADS)

Many discrete-time dynamical systems have a region Q from which all or almost all trajectories leave, or at least they leave in the presence of perturbations that we call disturbances. We partially control systems so that despite disturbances the trajectories of a dynamical system stay in the region Q at least for some initial points in Q. The disturbances can be thought of as either noise or as purposeful, hostile efforts of an enemy to drive the trajectory out of the region. Our goal is to keep trajectories inside Q despite the disturbances and our partial control of chaos method succeeds. Surprisingly this goal can be achieved with a control whose maximum allowable size is smaller than the maximum allowed disturbance. A fundamental step towards this goal is to compute a set called the safe set that had, until now, been found only in certain very special situations. This paper provides a general algorithm for computing safe sets. The algorithm is able to compute the safe sets for a specified region in phase space, the maximum disturbance value, and the maximum allowed control. We call it the Sculpting Algorithm. Its operation is analogous to removing material while sculpting a statue. The algorithm sculpts the safe sets. Our Sculpting Algorithm is independent of the dimension and is fast for one- and two-dimensional dynamical systems. As examples, we apply the algorithm to two paradigmatic nonlinear dynamical systems, namely, the Hénon map and the Duffing oscillator.

Sabuco, Juan; Zambrano, Samuel; Sanjuán, Miguel A. F.; Yorke, James A.

2012-11-01

6

Partial wave analysis of J/?????  

NASA Astrophysics Data System (ADS)

Based on a sample of 2.25×108 J/? events collected with the BESIII detector at BEPCII, a full partial wave analysis on J/????? was performed using the relativistic covariant tensor amplitude method. The results show that the dominant 0++ and 2++ components are from the f0(1710), f0(2100), f0(1500), f2'(1525), f2(1810) and f2(2340). The resonance parameters and branching fractions are also presented.

Ablikim, M.; Achasov, M. N.; Albayrak, O.; Ambrose, D. J.; An, F. F.; An, Q.; Bai, J. Z.; Baldini Ferroli, R.; Ban, Y.; Becker, J.; Bennett, J. V.; Berger, N.; Bertani, M.; Bian, J. M.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Bytev, V.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X.; Chen, Y. B.; Cheng, H. P.; Chu, Y. P.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J. P.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; Ding, W. M.; Ding, Y.; Dong, L. Y.; Dong, M. Y.; Du, S. X.; Fang, J.; Fang, S. S.; Fava, L.; Feng, C. Q.; Friedel, P.; Fu, C. D.; Fu, J. L.; Fuks, O.; Gao, Y.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, T.; Guo, Y. P.; Han, Y. L.; Harris, F. A.; He, K. L.; He, M.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Huang, G. M.; Huang, G. S.; Huang, J. S.; Huang, L.; Huang, X. T.; Huang, Y.; Huang, Y. P.; Hussain, T.; Ji, C. S.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. L.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jing, F. F.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Kopf, B.; Kornicer, M.; Kuehn, W.; Lai, W.; Lange, J. S.; Larin, P.; Leyhe, M.; Li, C. H.; Li, Cheng; Li, Cui; Li, D. M.; Li, F.; Li, G.; Li, H. B.; Li, J. C.; Li, K.; Li, Lei; Li, Q. J.; Li, S. L.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, X. R.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, X. T.; Lin, D.; Liu, B. J.; Liu, C. L.; Liu, C. X.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H.; Liu, H. B.; Liu, H. H.; Liu, H. M.; Liu, H. W.; Liu, J. P.; Liu, K.; Liu, K. Y.; Liu, Kai; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lu, G. R.; Lu, H. J.; Lu, J. G.; Lu, Q. W.; Lu, X. R.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lv, M.; Ma, C. L.; Ma, F. C.; Ma, H. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. Y.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Moeini, H.; Morales Morales, C.; Moriya, K.; Muchnoi, N. Yu.; Muramatsu, H.; Nefedov, Y.; Nicholson, C.; Nikolaev, I. B.; Ning, Z.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Ping, J. L.; Ping, R. G.; Poling, R.; Prencipe, E.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Rong, G.; Ruan, X. D.; Sarantsev, A.; Schaefer, B. D.; Shao, M.; Shen, C. P.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, W. M.; Song, X. Y.; Spataro, S.; Spruck, B.; Sun, D. H.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Toth, D.; Ullrich, M.; Uman, I.; Varner, G. S.; Wang, B. Q.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q. J.; Wang, S. G.; Wang, X. F.; Wang, X. L.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wei, D. H.; Wei, J. B.; Weidenkaff, P.; Wen, Q. G.; Wen, S. P.; Werner, M.; Wiedner, U.; Wu, L. H.; Wu, N.; Wu, S. X.; Wu, W.; Wu, Z.; Xia, L. G.; Xia, Y. X.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, G. M.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Xu, Z. R.; Xue, F.; Xue, Z.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. X.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yu, B. X.; Yu, C. X.; Yu, H. W.; Yu, J. S.; Yu, S. P.; Yuan, C. Z.; Yuan, Y.; Zafar, A. A.; Zallo, A.; Zang, S. L.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, LiLi; Zhang, R.; Zhang, S. H.; Zhang, X. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhang, Zhenghao; Zhao, G.; Zhao, H. S.; Zhao, J. W.; Zhao, K. X.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, X. H.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhu, C.; Zhu, K.; Zhu, K. J.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. M.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.

2013-05-01

7

Physics analysis of the gang partial rod drive event  

SciTech Connect

During the routine positioning of partial-length control rods in Gang 3 on the afternoon of Monday, July 27, 1992, the partial-length rods continued to drive into the reactor even after the operator released the controlling toggle switch. In response to this occurrence, the Safety Analysis and Engineering Services Group (SAEG) requested that the Applied Physics Group (APG) analyze the gang partial rod drive event. Although similar accident scenarios were considered in analysis for Chapter 15 of the Safety Analysis Report (SAR), APG and SAEG conferred and agreed that this particular type of gang partial-length rod motion event was not included in the SAR. This report details this analysis.

Boman, C.; Frost, R.L.

1992-08-01

8

Partial wave analysis at BESIII  

NASA Astrophysics Data System (ADS)

The BESIII experiment in Beijing takes data in ?-charm domain since 2009. For the moment the world largest samples of J/?, ?(3686), ?(3770) and ?(4040) data have been collected. Hadron spectroscopy is a unique way to access QCD, which is one of the most important physics goals of BESIII. Experimental search of new forms of hadrons and subsequent investigation of their properties would provide validation of and valuable input to the quantitative understanding of QCD. The key to success lies in high levels of precision during the measurement and high statistics in the recorded data set complemented with sophisticated analysis methods. Partial wave analysis (PWA) is a powerful tool to study the hadron spectroscopy, that allows one to extract the resonance's spin-parity, mass, width and decay properties with high sensitivity and accuracy. In this poster, we present the working PWA framework of BESIII - GPUPWA and the recent results of PWA of J/? ? ???. GPUPWA is a PWA framework for high statistics partial wave analyses harnessing the GPU parallel computing.

Liu, Beijiang

2014-05-01

9

Digital analysis of partial discharges  

Microsoft Academic Search

In this paper relevant aspects of digital processing of partial discharge (PD) as measured by conventional PD detection methods are discussed. Moreover, a systematic study of PD quantities is presented and discussed within the scope of practical PD analyzers, including recognition of defects in certain HV insulation configurations

Edward Gulski

1995-01-01

10

Model-Based Safety Analysis  

NASA Technical Reports Server (NTRS)

System safety analysis techniques are well established and are used extensively during the design of safety-critical systems. Despite this, most of the techniques are highly subjective and dependent on the skill of the practitioner. Since these analyses are usually based on an informal system model, it is unlikely that they will be complete, consistent, and error free. In fact, the lack of precise models of the system architecture and its failure modes often forces the safety analysts to devote much of their effort to gathering architectural details about the system behavior from several sources and embedding this information in the safety artifacts such as the fault trees. This report describes Model-Based Safety Analysis, an approach in which the system and safety engineers share a common system model created using a model-based development process. By extending the system model with a fault model as well as relevant portions of the physical system to be controlled, automated support can be provided for much of the safety analysis. We believe that by using a common model for both system and safety engineering and automating parts of the safety analysis, we can both reduce the cost and improve the quality of the safety analysis. Here we present our vision of model-based safety analysis and discuss the advantages and challenges in making this approach practical.

Joshi, Anjali; Heimdahl, Mats P. E.; Miller, Steven P.; Whalen, Mike W.

2006-01-01

11

Integrated Safety Analysis Teams  

NASA Technical Reports Server (NTRS)

Today's complex systems require understanding beyond one person s capability to comprehend. Each system requires a team to divide the system into understandable subsystems which can then be analyzed with an Integrated Hazard Analysis. The team must have both specific experiences and diversity of experience. Safety experience and system understanding are not always manifested in one individual. Group dynamics make the difference between success and failure as well as the difference between a difficult task and a rewarding experience. There are examples in the news which demonstrate the need to connect the pieces of a system into a complete picture. The Columbia disaster is now a standard example of a low consequence hazard in one part of the system; the External Tank is a catastrophic hazard cause for a companion subsystem, the Space Shuttle Orbiter. The interaction between the hardware, the manufacturing process, the handling, and the operations contributed to the problem. Each of these had analysis performed, but who constituted the team which integrated this analysis together? This paper will explore some of the methods used for dividing up a complex system; and how one integration team has analyzed the parts. How this analysis has been documented in one particular launch space vehicle case will also be discussed.

Wetherholt, Jonathan C.

2008-01-01

12

System safety engineering analysis handbook  

NASA Technical Reports Server (NTRS)

The basic requirements and guidelines for the preparation of System Safety Engineering Analysis are presented. The philosophy of System Safety and the various analytic methods available to the engineering profession are discussed. A text-book description of each of the methods is included.

Ijams, T. E.

1972-01-01

13

Partial wave analysis using graphics processing units  

NASA Astrophysics Data System (ADS)

Partial wave analysis is an important tool for determining resonance properties in hadron spectroscopy. For large data samples however, the un-binned likelihood fits employed are computationally very expensive. At the Beijing Spectrometer (BES) III experiment, an increase in statistics compared to earlier experiments of up to two orders of magnitude is expected. In order to allow for a timely analysis of these datasets, additional computing power with short turnover times has to be made available. It turns out that graphics processing units (GPUs) originally developed for 3D computer games have an architecture of massively parallel single instruction multiple data floating point units that is almost ideally suited for the algorithms employed in partial wave analysis. We have implemented a framework for tensor manipulation and partial wave fits called GPUPWA. The user writes a program in pure C++ whilst the GPUPWA classes handle computations on the GPU, memory transfers, caching and other technical details. In conjunction with a recent graphics processor, the framework provides a speed-up of the partial wave fit by more than two orders of magnitude compared to legacy FORTRAN code.

Berger, Niklaus; Beijiang, Liu; Jike, Wang

2010-04-01

14

Qualitative Analysis of Partially-Observable Markov Decision Processes  

NASA Astrophysics Data System (ADS)

We study observation-based strategies for partially-observable Markov decision processes (POMDPs) with parity objectives. An observation-based strategy relies on partial information about the history of a play, namely, on the past sequence of observations. We consider qualitative analysis problems: given a POMDP with a parity objective, decide whether there exists an observation-based strategy to achieve the objective with probability 1 (almost-sure winning), or with positive probability (positive winning). Our main results are twofold. First, we present a complete picture of the computational complexity of the qualitative analysis problem for POMDPs with parity objectives and its subclasses: safety, reachability, Büchi, and coBüchi objectives. We establish several upper and lower bounds that were not known in the literature. Second, we give optimal bounds (matching upper and lower bounds) for the memory required by pure and randomized observation-based strategies for each class of objectives.

Chatterjee, Krishnendu; Doyen, Laurent; Henzinger, Thomas A.

15

Measuring Safety Performance: A Comparison of Whole, Partial, and Momentary Time-Sampling Recording Methods  

ERIC Educational Resources Information Center

Partial-interval (PIR), whole-interval (WIR), and momentary time sampling (MTS) estimates were compared against continuous measures of safety performance for three postural behaviors: feet, back, and shoulder position. Twenty-five samples of safety performance across five undergraduate students were scored using a second-by-second continuous…

Alvero, Alicia M.; Struss, Kristen; Rappaport, Eva

2008-01-01

16

Analysis of partial recombinants in lentiviral vector preparations.  

PubMed

Abstract The presence of replication-competent lentivirus (RCL) in lentiviral vector preparations is a major safety concern for clinical applications of such vectors. RCL are believed to emerge from rare recombinant vector genomes that are referred to as partial recombinants or Psi-Gag recombinants. To quantitatively determine the fraction of partial recombinants in lentiviral vector preparations and to analyze them at the DNA sequence level, we established a drug selection assay involving a lentiviral packaging construct containing a drug-resistance gene encoding blasticidin (BSD) resistance. Upon transduction of target cells, the BSD resistance gene confers BSD resistance to the transduced cells. The results obtained indicate that there were up to 156 BSD-resistant colonies in a total of 10(6) transducing vector particles. The predicted recombination events were verified by polymerase chain reaction using genomic DNA obtained from BSD-resistant cell clones and by DNA sequence analysis. In an attempt to reduce the emergence of partial recombinants, sequence overlaps between the packaging and the vector constructs were reduced by substituting the Rev response element (RRE) present in the vector construct using a heterologous RRE element derived from simian immunodeficiency virus (SIVmac239). The results obtained showed that a reduction of sequence overlaps resulted in an up to sevenfold reduction of the frequency of BSD-resistant colonies, indicating that the capacity to form partial recombinants was diminished. PMID:24367910

Kuate, Seraphin; Marino, Michael P; Reiser, Jakob

2014-04-01

17

Partially Premixed Flame (PPF) Research for Fire Safety  

NASA Technical Reports Server (NTRS)

Incipient fires typically occur after the partial premixing of fuel and oxidizer. The mixing of product species into the fuel/oxidizer mixture influences flame stabilization and fire spread. Therefore, it is important to characterize the impact of different levels of fuel/oxidizer/product mixing on flame stabilization, liftoff and extinguishment under different gravity conditions. With regard to fire protection, the agent concentration required to achieve flame suppression is an important consideration. The initial stage of an unwanted fire in a microgravity environment will depend on the level of partial premixing and the local conditions such as air currents generated by the fire itself and any forced ventilation (that influence agent and product mixing into the fire). The motivation of our investigation is to characterize these impacts in a systematic and fundamental manner.

Puri, Ishwar K.; Aggarwal, Suresh K.; Lock, Andrew J.; Hegde, Uday

2004-01-01

18

Partial pressure analysis in space testing  

NASA Technical Reports Server (NTRS)

For vacuum-system or test-article analysis it is often desirable to know the species and partial pressures of the vacuum gases. Residual gas or Partial Pressure Analyzers (PPA's) are commonly used for this purpose. These are mass spectrometer-type instruments, most commonly employing quadrupole filters. These instruments can be extremely useful, but they should be used with caution. Depending on the instrument design, calibration procedures, and conditions of use, measurements made with these instruments can be accurate to within a few percent, or in error by two or more orders of magnitude. Significant sources of error can include relative gas sensitivities that differ from handbook values by an order of magnitude, changes in sensitivity with pressure by as much as two orders of magnitude, changes in sensitivity with time after exposure to chemically active gases, and the dependence of the sensitivity for one gas on the pressures of other gases. However, for most instruments, these errors can be greatly reduced with proper operating procedures and conditions of use. In this paper, data are presented illustrating performance characteristics for different instruments and gases, operating parameters are recommended to minimize some errors, and calibrations procedures are described that can detect and/or correct other errors.

Tilford, Charles R.

1994-01-01

19

Safety study application guide. Safety Analysis Report Update Program  

SciTech Connect

Martin Marietta Energy Systems, Inc., (Energy Systems) is committed to performing and documenting safety analyses for facilities it manages for the Department of Energy (DOE). Included are analyses of existing facilities done under the aegis of the Safety Analysis Report Upgrade Program, and analyses of new and modified facilities. A graded approach is used wherein the level of analysis and documentation for each facility is commensurate with the magnitude of the hazard(s), the complexity of the facility and the stage of the facility life cycle. Safety analysis reports (SARs) for hazard Category 1 and 2 facilities are usually detailed and extensive because these categories are associated with public health and safety risk. SARs for Category 3 are normally much less extensive because the risk to public health and safety is slight. At Energy Systems, safety studies are the name given to SARs for Category 3 (formerly {open_quotes}low{close_quotes}) facilities. Safety studies are the appropriate instrument when on-site risks are limited to irreversible consequences to a few people, and off-site consequences are limited to reversible consequences to a few people. This application guide provides detailed instructions for performing safety studies that meet the requirements of DOE Orders 5480.22, {open_quotes}Technical Safety Requirements,{close_quotes} and 5480.23, {open_quotes}Nuclear Safety Analysis Reports.{close_quotes} A seven-chapter format has been adopted for safety studies. This format allows for discussion of all the items required by DOE Order 5480.23 and for the discussions to be readily traceable to the listing in the order. The chapter titles are: (1) Introduction and Summary, (2) Site, (3) Facility Description, (4) Safety Basis, (5) Hazardous Material Management, (6) Management, Organization, and Institutional Safety Provisions, and (7) Accident Analysis.

Not Available

1993-07-01

20

Probabilistic Analysis of Semilinear Partial Differential Equations.  

National Technical Information Service (NTIS)

A major thrust of the original proposal was to find new probabilistic methods for dealing with semilinear partial differential equations. Mathematicians are currently devoting more of their attention to studying nonlinear partial differential equations si...

J. Glover K. L. Chung

1989-01-01

21

14 CFR 35.15 - Safety analysis.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 false Safety analysis. 35...Space FEDERAL AVIATION ADMINISTRATION... § 35.15 Safety analysis...probability of 10?7 or...not greater than 10?8 per propeller...stated in the safety analysis. ...An inability to change propeller...

2010-01-01

22

Probabilistic safety analysis procedures guide  

SciTech Connect

A procedures guide for the performance of probabilistic safety assessment has been prepared for interim use in the Nuclear Regulatory Commission programs. The probabilistic safety assessment studies performed are intended to produce probabilistic predictive models that can be used and extended by the utilities and by NRC to sharpen the focus of inquiries into a range of tissues affecting reactor safety. This guide addresses the determination of the probability (per year) of core damage resulting from accident initiators internal to the plant and from loss of offsite electric power. The scope includes analyses of problem-solving (cognitive) human errors, a determination of importance of the various core damage accident sequences, and an explicit treatment and display of uncertainties for the key accident sequences. Ultimately, the guide will be augmented to include the plant-specific analysis of in-plant processes (i.e., containment performance) and the risk associated with external accident initiators, as consensus is developed regarding suitable methodologies in these areas. This guide provides the structure of a probabilistic safety study to be performed, and indicates what products of the study are essential for regulatory decision making. Methodology is treated in the guide only to the extent necessary to indicate the range of methods which is acceptable; ample reference is given to alternative methodologies which may be utilized in the performance of the study.

Papazoglou, I.A.; Bari, R.A.; Buslik, A.J.; Hall, R.E.; Ilberg, D.; Samanta, P.K.; Teichmann, T.; Youngblood, R.W.; El-Bassioni, A.; Fragola, J.

1984-01-01

23

The new BNL partial wave analysis programs  

SciTech Connect

Experiment E852 at Brookhaven National Laboratory is a meson spectroscopy experiment which took data at the Multi-Particle Spectrometer facility of the Alternating Gradient Syncrotron. Upgrades to the spectrometer`s data acquisition and trigger electronics allowed over 900 million data events, of numerous topologies, to be recorded to tape in 1995 running alone. One of the primary goals of E852 is identification of states beyond the quark model, i.e., states with gluonic degrees of freedom. Identification of such states involves the measurement of a systems spin-parity. Such a measurement is usually done using Partial Wave Analysis. Programs to perform such analyses exist, in fact, one was written at BNL and used in previous experiments by some of this group. This program, however, was optimized for a particular final state, and modification to allow analysis of the broad range of final states in E852 would have been difficult. The authors therefore decided to write a new program, with an eye towards generality that would allow analysis of a large class of reactions.

Cummings, J.P.; Weygand, D.P.

1997-07-29

24

Regularized Partial and/or Constrained Redundancy Analysis  

ERIC Educational Resources Information Center

Methods of incorporating a ridge type of regularization into partial redundancy analysis (PRA), constrained redundancy analysis (CRA), and partial and constrained redundancy analysis (PCRA) were discussed. The usefulness of ridge estimation in reducing mean square error (MSE) has been recognized in multiple regression analysis for some time,…

Takane, Yoshio; Jung, Sunho

2008-01-01

25

SIMMER as a safety analysis tool  

SciTech Connect

SIMMER has been used for numerous applications in fast reactor safety, encompassing both accident and experiment analysis. Recent analyses of transition-phase behavior in potential core disruptive accidents have integrated SIMMER testing with the accident analysis. Results of both the accident analysis and the verification effort are presented as a comprehensive safety analysis program.

Smith, L.L.; Bell, C.R.; Bohl, W.R.; Bott, T.F.; Dearing, J.F.; Luck, L.B.

1982-01-01

26

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2010 CFR

... 2009-01-01 2009-01-01 false Flight safety limits analysis. 417.213 Section 417...TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.213 Flight safety limits analysis. (a) General. A...

2009-01-01

27

14 CFR 417.213 - Flight safety limits analysis.  

Code of Federal Regulations, 2010 CFR

... 2010-01-01 2010-01-01 false Flight safety limits analysis. 417.213 Section 417...TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.213 Flight safety limits analysis. (a) General. A...

2010-01-01

28

Risk-analysis procedures ensure system safety  

Microsoft Academic Search

Conducting risk analysis and safety- engineering studies before construction of a sour-gas pipeline system will build redundancies into the system and ensure safe operation and maintenance. A recent analysis of a sour-gas pipeline built in Texas provides an example of procedures for safety engineering and risk assessment. This first of two articles presents the risk-analysis methodology and minimum safety systems

M. Mannan; D. B. Pfenning; C. D. Zinn

1991-01-01

29

Geometric Partial Differential Equations and Image Analysis  

Microsoft Academic Search

This book provides an introduction to the use of geometric partial differential equations in image processing and computer vision. It brings a number of new concepts into the field, providing a very fundamental and formal approach to image processing. State-of-the-art practical results in a large number of real problems are achieved with the techniques described. Applications covered include image segmentation,

Guillermo Sapiro

2001-01-01

30

Automation for System Safety Analysis  

NASA Technical Reports Server (NTRS)

This presentation describes work to integrate a set of tools to support early model-based analysis of failures and hazards due to system-software interactions. The tools perform and assist analysts in the following tasks: 1) extract model parts from text for architecture and safety/hazard models; 2) combine the parts with library information to develop the models for visualization and analysis; 3) perform graph analysis and simulation to identify and evaluate possible paths from hazard sources to vulnerable entities and functions, in nominal and anomalous system-software configurations and scenarios; and 4) identify resulting candidate scenarios for software integration testing. There has been significant technical progress in model extraction from Orion program text sources, architecture model derivation (components and connections) and documentation of extraction sources. Models have been derived from Internal Interface Requirements Documents (IIRDs) and FMEA documents. Linguistic text processing is used to extract model parts and relationships, and the Aerospace Ontology also aids automated model development from the extracted information. Visualizations of these models assist analysts in requirements overview and in checking consistency and completeness.

Malin, Jane T.; Fleming, Land; Throop, David; Thronesbery, Carroll; Flores, Joshua; Bennett, Ted; Wennberg, Paul

2009-01-01

31

327 Building Safety Analysis Report  

SciTech Connect

The purpose of this document is to systematically identify and analyze the hazards associated with the stabilization and deactivation of the 327 Building. This SAR establishes the Safety Basis for the 327 Building and was prepared in accordance with HNF-3731,327 Building Safety Basis Criteria Document. Applied technology legend removed per DOE/HQ letter dated 10/29/2001.

HENDERSON, J.F.

2001-01-15

32

Principal Components Analysis and Partial Least Squares Regression.  

National Technical Information Service (NTIS)

The mathematics behind the techniques of principal component analysis and partial least squares regression is presented in detail, starting from the appropriate extrema conditions. The meaning of the resultant vectors and many of their mathematical interr...

W. G. Glen W. J. Dunn D. R. Scott

1989-01-01

33

PRINCIPAL COMPONENTS ANALYSIS AND PARTIAL LEAST SQUARES REGRESSION  

EPA Science Inventory

The mathematics behind the techniques of principal component analysis and partial least squares regression is presented in detail, starting from the appropriate extreme conditions. he meaning of the resultant vectors and many of their mathematical interrelationships are also pres...

34

Invariant painlevé analysis of partial differential equations  

Microsoft Academic Search

The whole Painlevé analysis of PDEs is shown to be invariant under an arbitrary homographic transformation of the function varphi defining the singularity manifold. The best expansion function is varkappa = (varphix\\/varphi-varphixx\\/2varphix)-1. This solves the ques tion of invariance under the Möbius group in Painlevé analysis and explains naturally Bäcklund transformation between solutions.

Robert Conte

1989-01-01

35

Contracting for Safety: A Concept Analysis  

Microsoft Academic Search

The concept of contracting for safety, although a popularly accepted method for managing suicidal patients, has no scientific evidence to support its effectiveness. There are questions regarding the clinical justification. This article provides a concept analysis of contracting for safety to evolve and clarify exemplary criteria of the concept within psychiatric nursing practice. At times in clinical practice, contracting is

Mary P. Egan

1997-01-01

36

Partial Wave Analysis of Coupled Photonic Structures  

NASA Technical Reports Server (NTRS)

The very high quality factors sustained by microcavity optical resonators are relevant to applications in wavelength filtering, routing, switching, modulation, and multiplexing/demultiplexing. Increases in the density of photonic elements require that attention be paid to how electromagnetic (EM) coupling modifies their optical properties. This is especially true when cavity resonances are involved, in which case, their characteristics may be fundamentally altered. Understanding the optical properties of microcavities that are near or in contact with photonic elements---such as other microcavities, nanostructures, couplers, and substrates---can be expected to advance our understanding of the roles that these structures may play in VLSI photonics, biosensors and similar device technologies. Wc present results from recent theoretical studies of the effects of inter- and intracavity coupling on optical resonances in compound spherical particles. Concentrically stratified spheres and bispheres constituted from homogeneous and stratified spheres are subjects of this investigation. A new formulation is introduced for the absorption of light in an arbitrary layer of a multilayered sphere, which is based on multiple reflections of the spherical partial waves of the Lorenz-Mie solution for scattering by a sphere. Absorption efficiencies, which can be used to profile cavity resonances and to infer fluorescence yields or the onset of nonlinear optical processes in the microcavities, are presented. Splitting of resonances in these multisphere systems is paid particular attention, and consequences for photonic device development and possible performance enhancements through carefully designed architectures that exploit EM coupling are considered.

Fuller, Kirk A.; Smith, David D.; Curreri, Peter A. (Technical Monitor)

2002-01-01

37

Nuclear Power Safety Reporting System: Feasibility Analysis.  

National Technical Information Service (NTIS)

This report is the first of two volumes, and describes the results of an analysis of the Federal Aviation Administration sponsored Aviation Safety Reporting System (ASRS), to determine ASRS features which might be adopted to a nuclear industry system. The...

F. C. Finlayson J. Ims

1983-01-01

38

327 Building Safety Analysis Report.  

National Technical Information Service (NTIS)

The purpose of this document is to systematically identify and analyze the hazards associated with the stabilization and deactivation of the 327 Building. This SAR establishes the Safety Basis for the 327 Building and was prepared in accordance with HNF-3...

A. M. Homer J. F. Henderson

2001-01-01

39

Active learning of plans for safety and reachability goals with partial observability.  

PubMed

Traditional planning assumes reachability goals and/or full observability. In this paper, we propose a novel solution for safety and reachability planning with partial observability. Given a planning domain, a safety property, and a reachability goal, we automatically learn a safe permissive plan to guide the planning domain so that the safety property is not violated and that can force the planning domain to eventually reach states that satisfy the reachability goal, regardless of how the planning domain behaves. Our technique is based on the active learning of regular languages and symbolic model checking. The planning method first learns a safe plan using the L (*) algorithm, which is an efficient active learning algorithm for regular languages. We then check whether the safe plan learned is also permissive by Alternating-time Temporal Logic (ATL) model checking. If the plan is permissive, it is indeed a safe permissive plan. Otherwise, we identify and add a safe string to converge a safe permissive plan. We describe an implementation of the proposed technique and demonstrate that our tool can efficiently construct safe permissive plans for four sets of examples. PMID:19661004

Nam, Wonhong; Alur, Rajeev

2010-04-01

40

Uncertainty analysis for Ulysses safety evaluation report  

NASA Technical Reports Server (NTRS)

As part of the effort to review the Ulysses Final Safety Analysis Report and to understand the risk of plutonium release from the Ulysses spacecraft General Purpose Heat Source-Radioisotope Thermal Generator, the Interagency Nuclear Safety Review Panel (INSRP) performed an integrated, quantitative analysis of the uncertainties of the calculated risk of plutonium release from Ulysses. Using state-of-art probabilistic risk assessment technology, the uncertainty analysis accounted for both variability and uncertainty of the key parameters of the risk analysis. The results show that INSRP had high confidence that risk of fatal cancers from potential plutonium release associated with calculated launch and deployment accident scenarios is low.

Frank, Michael V.

1991-01-01

41

Uncertainty analysis for Ulysses safety evaluation report  

NASA Astrophysics Data System (ADS)

As part of the effort to review the Ulysses Final Safety Analysis Report and to understand the risk of plutonium release from the Ulysses spacecraft General Purpose Heat Source-Radioisotope Thermal Generator, the Interagency Nuclear Safety Review Panel (INSRP) performed an integrated, quantitative analysis of the uncertainties of the calculated risk of plutonium release from Ulysses. Using state-of-art probabilistic risk assessment technology, the uncertainty analysis accounted for both variability and uncertainty of the key parameters of the risk analysis. The results show that INSRP had high confidence that risk of fatal cancers from potential plutonium release associated with calculated launch and deployment accident scenarios is low.

Frank, Michael V.

42

Partial analysis of experiment LDEF A-0114  

NASA Technical Reports Server (NTRS)

Due to delays in manifesting the return of the Long Duration Exposure Facility from space, attention was concentrated on extracting the maximum information from the EIOM-2 (oxygen interaction with materials experiment) flown on STS-8 in September 1983. An analysis was made of the optical surfaces exposed during that flight and an assessment made of the effect of the 5 eV atomic oxygen upon their physical and chemical properties. The surfaces studied were of two types: high-purity thin films sputtered or evaporated onto 2.54-cm diam lambda/20 fused silica optical flats, and highly polished bulk samples. Rapid etching of carbon and carbonaceous surfaces was observed with polycarbonate CR-39 showing the largest etch of any substrate flown and measured. Of the metals tested, only osmium and silver showed large effects, the former being heavily etched and the later forming a very thick layer of oxide. The first measurable effects on iridium, aluminum, nickel, tungsten and niobium thin films are reported.

Gregory, J. C.

1986-01-01

43

Partial analysis of experiment LDEF A-0114  

NASA Astrophysics Data System (ADS)

Due to delays in manifesting the return of the Long Duration Exposure Facility from space, attention was concentrated on extracting the maximum information from the EIOM-2 (oxygen interaction with materials experiment) flown on STS-8 in September 1983. An analysis was made of the optical surfaces exposed during that flight and an assessment made of the effect of the 5 eV atomic oxygen upon their physical and chemical properties. The surfaces studied were of two types: high-purity thin films sputtered or evaporated onto 2.54-cm diam lambda/20 fused silica optical flats, and highly polished bulk samples. Rapid etching of carbon and carbonaceous surfaces was observed with polycarbonate CR-39 showing the largest etch of any substrate flown and measured. Of the metals tested, only osmium and silver showed large effects, the former being heavily etched and the later forming a very thick layer of oxide. The first measurable effects on iridium, aluminum, nickel, tungsten and niobium thin films are reported.

Gregory, J. C.

1986-05-01

44

Facilitating Analysis of Multiple Partial Data Streams  

NASA Technical Reports Server (NTRS)

Robotic Operations Automation: Mechanisms, Imaging, Navigation report Generation (ROAMING) is a set of computer programs that facilitates and accelerates both tactical and strategic analysis of time-sampled data especially the disparate and often incomplete streams of Mars Explorer Rover (MER) telemetry data described in the immediately preceding article. As used here, tactical refers to the activities over a relatively short time (one Martian day in the original MER application) and strategic refers to a longer time (the entire multi-year MER missions in the original application). Prior to installation, ROAMING must be configured with the types of data of interest, and parsers must be modified to understand the format of the input data (many example parsers are provided, including for general CSV files). Thereafter, new data from multiple disparate sources are automatically resampled into a single common annotated spreadsheet stored in a readable space-separated format, and these data can be processed or plotted at any time scale. Such processing or plotting makes it possible to study not only the details of a particular activity spanning only a few seconds, but also longer-term trends. ROAMING makes it possible to generate mission-wide plots of multiple engineering quantities [e.g., vehicle tilt as in Figure 1(a), motor current, numbers of images] that, heretofore could be found only in thousands of separate files. ROAMING also supports automatic annotation of both images and graphs. In the MER application, labels given to terrain features by rover scientists and engineers are automatically plotted in all received images based on their associated camera models (see Figure 2), times measured in seconds are mapped to Mars local time, and command names or arbitrary time-labeled events can be used to label engineering plots, as in Figure 1(b).

Maimone, Mark W.; Liebersbach, Robert R.

2008-01-01

45

Analysis of partially textured slider and journal bearing  

NASA Astrophysics Data System (ADS)

The partial texturing of bearing surfaces with different shapes of textures and at different locations is an effective approach to improve the performance of bearings. The present study examines the effects of texture configuration on improvement in load capacity and reduction in friction coefficient for slider and journal bearing. This work presents nondimensional pressure expressions for the partially textured slider and journal bearing. The nondimensional pressure expressions are derived taking into consideration of texture geometry and extent of partial texture on the bearing surface. The Reynolds boundary conditions are used in the analysis to predict nondimensional load capacity and coefficient of friction. Even for nominally parallel surfaces, partial texturing of bearing surfaces has a potential to generate load carrying capacity and reduce coefficient of friction.

Rao, T. V. V. L. N.; Rani, A. M. A.; Nagarajan, T.; Hashim, F. M.

2012-06-01

46

The practical implementation of integrated safety management for nuclear safety analysis and fire hazards analysis documentation  

SciTech Connect

In 1995 Mr. Joseph DiNunno of the Defense Nuclear Facilities Safety Board issued an approach to describe the concept of an integrated safety management program which incorporates hazard and safety analysis to address a multitude of hazards affecting the public, worker, property, and the environment. Since then the U S . Department of Energy (DOE) has adopted a policy to systematically integrate safety into management and work practices at all levels so that missions can be completed while protecting the public, worker, and the environment. While the DOE and its contractors possessed a variety of processes for analyzing fire hazards at a facility, activity, and job; the outcome and assumptions of these processes have not always been consistent for similar types of hazards within the safety analysis and the fire hazard analysis. Although the safety analysis and the fire hazard analysis are driven by different DOE Orders and requirements, these analyses should not be entirely independent and their preparation should be integrated to ensure consistency of assumptions, consequences, design considerations, and other controls. Under the DOE policy to implement an integrated safety management system, identification of hazards must be evaluated and agreed upon to ensure that the public. the workers. and the environment are protected from adverse consequences. The DOE program and contractor management need a uniform, up-to-date reference with which to plan. budget, and manage nuclear programs. It is crucial that DOE understand the hazards and risks necessarily to authorize the work needed to be performed. If integrated safety management is not incorporated into the preparation of the safety analysis and the fire hazard analysis, inconsistencies between assumptions, consequences, design considerations, and controls may occur that affect safety. Furthermore, confusion created by inconsistencies may occur in the DOE process to grant authorization of the work. In accordance with the integrated safety management system approach for having a uniform and consistent process: a method has been suggested by the U S . Department of Energy at Richland and the Project Hanford Procedures when fire hazard analyses and safety analyses are required. This process provides for a common basis approach in the development of the fire hazard analysis and the safety analysis. This process permits the preparers of both documents to jointly participate in the development of the hazard analysis process. This paper presents this method to implement the integrated safety management approach in the development of the fire hazard analysis and safety analysis that provides consistency of assumptions. consequences, design considerations, and other controls necessarily to protect workers, the public. and the environment.

COLLOPY, M.T.

1999-05-04

47

Variable Selection in Discriminant Partial Least-Squares Analysis  

Microsoft Academic Search

Variable selection enhances the understanding and inter- pretability of multivariate classification models. A new chemometric method based on the selection of the most important variables in discriminant partial least-squares (VS-DPLS) analysis is described. The suggested method is a simple extension of DPLS where a small number of elements in the weight vector w is retained for each factor. The optimal

Bjørn K. Alsberg; Douglas B. Kell; Royston Goodacre

1998-01-01

48

SLAC three-body partial wave analysis system  

SciTech Connect

We present a heuristic description of the SLAC-LBL three-meson partial wave model, and describe how we have implemented it at SLAC. The discussion details the assumptions of the model and the analysis, and emphasizes the methods we have used to prepare and fit the data. 28 refs., 12 figs., 1 tab.

Aston, D.; Lasinski, T.A.; Sinervo, P.K.

1985-10-01

49

TRIAGE DOSE ASSESSMENT FOR PARTIAL-BODY EXPOSURE: DICENTRIC ANALYSIS  

PubMed Central

Partial-body biodosimetry is likely to be required after a radiological or nuclear exposure. Clinical signs and symptoms, distribution of dicentrics in circulating blood cells, organ-specific biomarkers, physical signals in teeth and nails all can provide indications of non-homogeneous exposures. Organ specific biomarkers may provide early warning regarding physiological systems at risk after radiation injury. Use of a combination of markers and symptoms will be needed for clinical insights for therapeutic approaches. Analysis of dicentrics, a marker specific for radiation injury, is the “Gold standard” of biodosimetry and can reveal partial-body exposures. Automation of sample processing for dicentric analysis can increase throughput with customization of off-the-shelf technologies for cytogenetic sample processing and information management. Automated analysis of the metaphase spreads is currently limited but improvements are in development. Our efforts bridge the technological gaps to allow the use of dicentric chromosome assay (DCA) for risk-based stratification of mass casualties. This article summarizes current knowledge on partial-body cytogenetic dose assessment synthesizing information leading to the proposal of an approach to triage dose prediction in radiation mass casualties, based on equivalent whole-body doses under partial-body exposure conditions and assesses the validity of using this model. An initial screening using only 20 metaphase spreads per subject can confirm irradiation above 2-Gy. A subsequent increase to 50 metaphases improves dose determination to allow risk stratification for clinical triage. Metaphases evaluated for inhomogeneous distribution of dicentrics can reveal partial-body exposures. We tested the validity of this approach in an in vitro model that simulates partial-body irradiation by mixing irradiated and un-irradiated lymphocytes in various proportions. Our preliminary results support the notion that this approach will be effective under a range of conditions including some partial-body exposures, but may have limitations with low doses or small proportions of irradiated body. Our studies address an important problem in the diagnosis of partial-body irradiation and dose assessment in mass casualties and propose a solution. However, additional work is needed to fully develop and validate the application of DCA to partial-body exposures.

Moroni, Maria; Pellmar, Terry C.

2009-01-01

50

Triage dose assessment for partial-body exposure: dicentric analysis.  

PubMed

Partial-body biodosimetry is likely to be required after a radiological or nuclear exposure. Clinical signs and symptoms, distribution of dicentrics in circulating blood cells, organ-specific biomarkers, and physical signals in teeth and fingernails all can provide indications of non-homogeneous exposures. Organ specific biomarkers may provide early warning regarding physiological systems at risk after radiation injury. Use of a combination of markers and symptoms will be needed for clinical insights for therapeutic approaches. Analysis of dicentrics, a marker specific for radiation injury, is the "gold standard" of biodosimetry and can reveal partial-body exposures. Automation of sample processing for dicentric analysis can increase throughput with customization of off-the-shelf technologies for cytogenetic sample processing and information management. Automated analysis of the metaphase spreads is currently limited, but improvements are in development. The efforts described here bridge the technological gaps to allow the use of dicentric chromosome assay (DCA) for risk-based stratification of mass casualties. This article summarizes current knowledge on partial-body cytogenetic dose assessment, synthesizing information leading to the proposal of an approach to triage dose prediction in radiation mass casualties that is based on equivalent whole-body doses under partial-body exposure conditions and assesses the validity of using this model. An initial screening using only 20 metaphase spreads per subject can confirm irradiation above 2 Gy. A subsequent increase to 50 metaphases improves dose determination to allow risk stratification for clinical triage. Metaphases evaluated for inhomogeneous distribution of dicentrics can reveal partial-body exposures. The authors tested the validity of this approach in an in vitro model that simulates partial-body irradiation by mixing irradiated and un-irradiated lymphocytes in various proportions. Preliminary results support the notion that this approach will be effective under a range of conditions including some partial-body exposures, but may have limitations with low doses or small proportions of irradiated parts of the body. These studies address an important problem in the diagnosis of partial-body irradiation and dose assessment in mass casualties and propose a solution. However, additional work is needed to fully develop and validate the application of DCA to partial-body exposures. PMID:20065689

Prasanna, Pataje G S; Moroni, Maria; Pellmar, Terry C

2010-02-01

51

Waste Isolation Pilot Plant Safety Analysis Report  

SciTech Connect

The following provides a summary of the specific issues addressed in this FY-95 Annual Update as they relate to the CH TRU safety bases: Executive Summary; Site Characteristics; Principal Design and Safety Criteria; Facility Design and Operation; Hazards and Accident Analysis; Derivation of Technical Safety Requirements; Radiological and Hazardous Material Protection; Institutional Programs; Quality Assurance; and Decontamination and Decommissioning. The System Design Descriptions`` (SDDS) for the WIPP were reviewed and incorporated into Chapter 3, Principal Design and Safety Criteria and Chapter 4, Facility Design and Operation. This provides the most currently available final engineering design information on waste emplacement operations throughout the disposal phase up to the point of permanent closure. Also, the criteria which define the TRU waste to be accepted for disposal at the WIPP facility were summarized in Chapter 3 based on the WAC for the Waste Isolation Pilot Plant.`` This Safety Analysis Report (SAR) documents the safety analyses that develop and evaluate the adequacy of the Waste Isolation Pilot Plant Contact-Handled Transuranic Wastes (WIPP CH TRU) safety bases necessary to ensure the safety of workers, the public and the environment from the hazards posed by WIPP waste handling and emplacement operations during the disposal phase and hazards associated with the decommissioning and decontamination phase. The analyses of the hazards associated with the long-term (10,000 year) disposal of TRU and TRU mixed waste, and demonstration of compliance with the requirements of 40 CFR 191, Subpart B and 40 CFR 268.6 will be addressed in detail in the WIPP Final Certification Application scheduled for submittal in October 1996 (40 CFR 191) and the No-Migration Variance Petition (40 CFR 268.6) scheduled for submittal in June 1996. Section 5.4, Long-Term Waste Isolation Assessment summarizes the current status of the assessment.

NONE

1995-11-01

52

Presurgical multimodality neuroimaging analysis for complex partial seizures  

NASA Astrophysics Data System (ADS)

Surgical treatment of patients suffering from complex partial seizures requires the localization of the epileptogenic zone for surgical resection. Currently, clinicians utilize electroencephalography (EEG), psychological tests, and various neuroimaging modalities together to determine the location of this zone. We investigate the use of positron emission tomography (PET), magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS) in the presurgical workup and analysis of patients with complex partial seizures. The results of imaging studies of 25 patients are compared for lateralization accuracy and relative concordance.

Wong, Stephen T.; Soo Hoo, Kent; Knowlton, Robert C.; Laxer, Kenneth D.; Hawkins, Randall A.; Rowley, Howard A.; Weiner, Michael W.

1998-07-01

53

SYNTHESIS OF SAFETY ANALYSIS AND FIRE HAZARD ANALYSIS METHODOLOGIES  

SciTech Connect

Successful implementation of both the nuclear safety program and fire protection program is best accomplished using a coordinated process that relies on sound technical approaches. When systematically prepared, the documented safety analysis (DSA) and fire hazard analysis (FHA) can present a consistent technical basis that streamlines implementation. If not coordinated, the DSA and FHA can present inconsistent conclusions, which can create unnecessary confusion and can promulgate a negative safety perception. This paper will compare the scope, purpose, and analysis techniques for DSAs and FHAs. It will also consolidate several lessons-learned papers on this topic, which were prepared in the 1990s.

Coutts, D

2007-04-17

54

DESIGN PACKAGE 1E SYSTEM SAFETY ANALYSIS  

SciTech Connect

The purpose of this analysis is to systematically identify and evaluate hazards related to the Yucca Mountain Project Exploratory Studies Facility (ESF) Design Package 1E, Surface Facilities, (for a list of design items included in the package 1E system safety analysis see section 3). This process is an integral part of the systems engineering process; whereby safety is considered during planning, design, testing, and construction. A largely qualitative approach was used since a radiological System Safety Analysis is not required. The risk assessment in this analysis characterizes the accident scenarios associated with the Design Package 1E structures/systems/components(S/S/Cs) in terms of relative risk and includes recommendations for mitigating all identified risks. The priority for recommending and implementing mitigation control features is: (1) Incorporate measures to reduce risks and hazards into the structure/system/component design, (2) add safety devices and capabilities to the designs that reduce risk, (3) provide devices that detect and warn personnel of hazardous conditions, and (4) develop procedures and conduct training to increase worker awareness of potential hazards, on methods to reduce exposure to hazards, and on the actions required to avoid accidents or correct hazardous conditions.

M. Salem

1995-06-23

55

324 building safety analysis report supplement  

Microsoft Academic Search

Process engineering designs, major equipment and plant facilities to be utilized in commercial nuclear waste preparation and vitrification in the 324 Radiochemical Engineering Building are reviewed with regard to accident potential and consequences. This Safety Analysis Report Supplement compares calculated environmental doses anticipated from the Commercial Nuclear Waste Vitrification Project (CNWVP) routine operations with the average doses from past waste

A. O. Dodd; N. G. Wittenbrock

1977-01-01

56

Uncertainty analysis for Ulysses safety evaluation report  

NASA Astrophysics Data System (ADS)

As part of the effort to review the Ulysses Final Safety Analysis Report and to understand the risk of plutonium release from the Ulysses spacecraft General Purpose Heat Source-Radioisotope Thermal Generator (GPHS-RTG), the Interagency Nuclear Safety Review Panel (INSRP) and the author performed an integrated, quantitative analysis of the uncertainties of the calculated risk of plutonium release from Ulysses. Using state-of-art probabilistic risk assessment technology, the uncertainty analysis accounted for both variability and uncertainty of the key parameters of the risk analysis. The results show that INSRP had high confidence that risk of fatal cancers from potential plutonium release associated with calculated launch and deployment accident scenarios is low.

Frank, Michael V.

1991-01-01

57

Safety analysis review terms of reference  

SciTech Connect

This document has been prepared to suggest procedures and items for consideration in the review of safety analysis prepared on DOE fossil energy conversion and technology development projects. It is not intended to reflect official DOE policy. It does, however, provide a basis for consistency in conducting reviews, especially with regard to interpreting levels of risk. Since many of the persons assigned to review panels are not expected to be safety analysts but specialists in related fields such as industrial hygiene and environmental science, this document is intended to provide general terms of reference to facilitate review procedures.

Hurley, T.

1981-03-01

58

Challenge to introduce MBSA approaches into CBTC safety analysis  

Microsoft Academic Search

and communication­ dependent derived from Communication based Train Control System (CBTC) t,traditional safety analysis approaches gradually betray the deficiencies of loose consistency of safety and design processes and duplicate work on safety assessment. In this paper, two of prominent proposed model based safety analysis (MBSA) approaches: failure logic modeling and failure effect modeling are introduced to deal with these two

Chao Liu; Tao Tang; Oleg Lisagor

2011-01-01

59

Transcriptome analysis of hepatocytes after partial hepatectomy in rats  

Microsoft Academic Search

After partial hepatectomy (PH), the recovery of liver mass is mainly mediated by proliferation and enlargement of hepatocytes.\\u000a Therefore, measuring the transcriptional profiling of hepatocytes after PH will be helpful in exploring the mechanism of liver\\u000a regeneration (LR). Firstly, hepatocytes were isolated from rat regenerating liver at different time points following PH, and\\u000a then global gene expression analysis of hepatocytes

Cunshuan Xu; Xiaoguang Chen; Cuifang Chang; Gaiping Wang; Wenbo Wang; Lianxing Zhang; Qiushi Zhu; Lei Wang; Fuchun Zhang

2010-01-01

60

Laparoscopic posterior partial fundoplication: analysis of 100 consecutive cases.  

PubMed

Performance of a laparoscopic posterior partial fundoplication (LPPF) for severe gastroesophageal reflux disease may have significant advantages. These include a low incidence of postop dysphagia, maintenance of the ability to belch, excellent antireflux effects, and the ease of performance of the surgery. The purpose of this study was to evaluate this antireflux procedure for these advantages to determine both its safety and effectiveness. Over 200 LPPFs have been performed by the authors in a community setting. One hundred consecutive cases are evaluated for indications, preop, and postop studies (EGD, manometry, 24 h pH), time of operation, hospital stay, complications, and conversions to an open procedure. Our technique of LPPF is presented in detail. All patients maintained the ability to belch. Postop dysphagia resolved totally in 4 patients by 7 days. Four pneumothoraces occurred; 1 patient required bilateral chest tube placement. There were no esophageal, stomach, or splenic injuries. The average hospital stay was 1.6 days. Postop 24 h pH studies revealed resolution of the esophageal reflux. Postop manometric studies show a median increase of 9.2 mm Hg for the LES pressure. No patients have resumed antireflux medication. No short gastric vessels were divided and no esophageal sutures were placed. There were no conversions to a laparotomy. Laparoscopic posterior partial fundoplication is a safe and effective antireflux procedure. PMID:8807514

O'Reilly, M J; Mullins, S G; Saye, W B; Pinto, S E; Falkner, P T

1996-06-01

61

Identification of Security-Safety Requirements for the Outdoor Robot RAVON Using Safety Analysis Techniques  

Microsoft Academic Search

This paper presents a case study for identifying security-safety requirements by using safety analysis techniques. In order to construct distributed software-intensive safety-critical systems, it is crucial to identify not only the safety requirements, but also the security requirements simultaneously, due to the fact that security attacks on the communication channels could cause safety consequences, such as damage to properties or

Zhensheng Guo; Dirk Zeckzer; Peter Liggesmeyer; Oliver Mäckel

2010-01-01

62

Safety of GM crops: compositional analysis.  

PubMed

The compositional analysis of genetically modified (GM) crops has continued to be an important part of the overall evaluation in the safety assessment program for these materials. The variety and complexity of genetically engineered traits and modes of action that will be used in GM crops in the near future, as well as our expanded knowledge of compositional variability and factors that can affect composition, raise questions about compositional analysis and how it should be applied to evaluate the safety of traits. The International Life Sciences Institute (ILSI), a nonprofit foundation whose mission is to provide science that improves public health and well-being by fostering collaboration among experts from academia, government, and industry, convened a workshop in September 2012 to examine these and related questions, and a series of papers has been assembled to describe the outcomes of that meeting. PMID:24266762

Brune, Philip D; Culler, Angela Hendrickson; Ridley, William P; Walker, Kate

2013-09-01

63

Survey of available software-safety analysis techniques  

Microsoft Academic Search

A survey is presented of the various software safety analysis techniques and methodologies. The techniques include software fault trees, sneak circuit analysis, nuclear safety cross-check analysis (NSCCA) and Petri nets. The author defines each technique as it applies to software safety and the utility of each model and its applicability based on system complexity

Mark D. Hansen; Colorado Springs

1989-01-01

64

Partial-wave analysis of K{sup +}-nucleon scattering  

SciTech Connect

We have performed a partial-wave analysis of K{sup +}-nucleon scattering in the momentum range from 0 to 1.5 GeV/c addressing the uncertainties of the results and comparing them with several previous analyses. It is found that the treatment of the reaction threshold behavior is particularly important. We find a T=0 scattering length which is not consistent with zero, as has been claimed by other analyses. The T=0 phase shifts for l>0 are consistent with a pure spin-orbit potential. Some indications for the production of a T=0 pentaquark with spin-parity-D5/2+ are discussed.

Gibbs, W. R.; Arceo, R. [Department of Physics, New Mexico State University, Las Cruces, New Mexico 88003 (United States)

2007-03-15

65

Free vibration analysis of partially filled liquid storage tanks  

SciTech Connect

A study on the free vibration analysis of partially filled liquid storage tanks is presented. The tanks considered are the upright circular cylindrical tanks that are rigidly supported at the base. The top of the tanks are either free or constrained. Two types of constraints are considered, namely, hinged and roller support. The governing differential equations for the tank-liquid system are obtained by application of the Rayleigh-Ritz procedure in combination with Lagrange`s equation. The response functions examined include the frequency of the fundamental mode of vibration of the tank-liquid system and the associated modal pressure.

Tang, Yu; Chang, Y.W.

1993-05-01

66

Free vibration analysis of partially filled liquid storage tanks  

SciTech Connect

A study on the free vibration analysis of partially filled liquid storage tanks is presented. The tanks considered are the upright circular cylindrical tanks that are rigidly supported at the base. the top of the tanks are either free or constrained. Two types of constraints are considered, namely, hinged and roller support. The governing differential equations for the tank-liquid system are obtained by application of the Rayleigh-Ritz procedure in combination with Lagrange`s equation. The response functions examined include the frequency of the fundamental mode of vibration of the tank-liquid system and the associated modal pressure.

Tang, Yu; Chang, Y.W.

1994-06-01

67

Lunar lava tube radiation safety analysis  

NASA Technical Reports Server (NTRS)

For many years it has been suggested that lava tubes on the Moon could provide an ideal location for a manned lunar base, by providing shelter from various natural hazards, such as cosmic radiation, meteorites, micrometeoroids, and impact crater ejecta, and also providing a natural environmental control, with a nearly constant temperature, unlike that of the lunar surface showing extreme variation in its diurnal cycle. An analysis of radiation safety issues on lunar lava tubes has been performed by considering radiation from galactic cosmic rays (GCR) and Solar Particle Events (SPE) interacting with the lunar surface, modeled as a regolith layer and rock. The chemical composition has been chosen as typical of the lunar regions where the largest number of lava tube candidates are found. Particles have been transported all through the regolith and the rock, and received particles flux and doses have been calculated. The radiation safety of lunar lava tubes environments has been demonstrated.

De Angelis, Giovanni; Wilson, J. W.; Clowdsley, M. S.; Nealy, J. E.; Humes, D. H.; Clem, J. M.

2002-01-01

68

Partial differential equations and fractal analysis to plant leaf identification  

NASA Astrophysics Data System (ADS)

Texture is an important visual attribute used to plant leaf identification. Although there are many methods of texture analysis, some of them specifically for interpreting leaf images is still a challenging task because of the huge pattern variation found in nature. In this paper, we investigate the leaf texture modeling based on the partial differential equations and fractal dimension theory. Here, we are first interested in decomposing the original texture image into two components f = u + v, such that u represents a cartoon component, while v represents the oscillatory component. We demonstrate how this procedure enhance the texture component on images. Our modeling uses the non-linear partial differential equation (PDE) of Perona-Malik. Based on the enhanced texture component, we estimated the fractal dimension by the Bouligand-Minkowski method due to its precision in quantifying structural properties of images. The feature vectors are then used as inputs to our classification system, based on linear discriminant analysis. We validate our approach on a benchmark with 8000 leaf samples. Experimental results indicate that the proposed approach improves average classification rates in comparison with traditional methods. The results suggest that the proposed approach can be a feasible step for plant leaf identification, as well as different real-world applications.

Brandoli Machado, Bruno; Casanova, Dalcimar; Nunes Gonçalves, Wesley; Martinez Bruno, Odemir

2013-02-01

69

FEM analysis of partial flash processing for a plate  

NASA Astrophysics Data System (ADS)

FEM analysis of Partial Flash Processing (PFP) was carried out by ANSYS to simulate the heat treatment of wear-resistant steel plate. PFP involves rapid induction heating and water cooling to get different properties of a plate in thickness direction. The steel plate which moves at a given velocity is heated by a stationary inductor and then cooled by spraying water. The temperature filed and the difference of microstructure and properties of the plate in PFP were studied. The electromagnetic and thermal coupled problem will be solved by sequentially coupled physics analysis. The nonlinearities of both the electromagnetic and thermal material properties are also taken into account. Cooling condition will be loaded as a function of water spray position on the surface of steel plate. The FEM analysis results are compared with the measure data, and they are in good accordance. The microstructure and the depth of hardening layer prove the FEM analysis results are credible. The relationship between the temperature distribution and the processing parameters, such as induction frequency, current density etc., were built up. The numerical analysis provides a basis for further theoretical analysis and parameter optimization of PFP.

Chen, Qing-an; Liu, Xiang-hua

2013-05-01

70

Quantum scattering problem without partial-wave analysis  

SciTech Connect

We have suggested a method for treating different quantum few-body dynamics without traditional using of the partial-wave analysis. It happened that this approach was very efficient in quantitative analysis of low-dimensional ultracold few-body systems arising in confined geometry of atomic traps. Here we discuss its application to a recently suggested mechanism of resonant molecule formation in confined two-component atomic mixture with transferring the energy release to the center-of-mass excitation of forming molecules. The author considers this result as one of the most significant in his scientific carrier which started from the model of resonant muonic molecule formation [S.I. Vinitsky et al., Sov. Phys. JETP 47, 444 (1978)], one of the most citing works of S.I. Vinitsky.

Melezhik, V. S., E-mail: melezhik@theor.jinr.ru [Joint Institute for Nuclear Research, Bogoliubov Laboratory of Theoretical Physics (Russian Federation)

2013-02-15

71

Safety Analysis in Conceptual Design of Process Control.  

National Technical Information Service (NTIS)

The thesis focuses on the conceptual design of process control systems, and on the problem of safety requirements determination. Safety analysis methods of process design are applied to tackle the problem and the information gap between process designers ...

A. Toola

1992-01-01

72

Fire Safety Analysis of the 270' WMEC Medium Endurance Cutter.  

National Technical Information Service (NTIS)

This report documents the results of a comprehensive fire safety analysis of the 270' WMEC Medium Endurance Cutter. The Ship Fire Safety Engineering Methodology (SFSEM) and associated computer program, SAFE version 2. 2, were utilized as an analytical too...

A. V. Prasad B. Dolph C. M. Sprague D. A. White

1998-01-01

73

Natural circulation reactor design safety analysis  

NASA Astrophysics Data System (ADS)

This thesis study covers both global performance and local phenomena analyses focusing on natural circulation reactor design safety. Four important topics are included: the global SBWR design safety assessment, important local phenomena investigation, steady and transient natural circulation process study, and two-phase instability analysis. The conceptual design of the SBWR-200 is introduced in this thesis and the global performance of a natural circulation reactor is then assessed using PUMA integral test data and RELAP5 simulations. A safety assessment methodology is developed to evaluate the PUMA integral test data extrapolation and code scalability. The RELAP5 code simulation capability in low-pressure low-flow conditions is also validated. The study shows that the code is capable of predicting the global accident scenario in natural circulation reactors with reasonable accuracy, while failing to reproduce some safety related local phenomena. The natural circulation process is investigated in detail using PUMA separate effect natural circulation tests. The natural circulation flow rate and heat transfer rate have been modeled analytically and numerically. The work indicates that two-phase natural circulation has enough capability to remove decay power. However, the flow instability observed in two-phase natural circulation cases seriously challenges the feasibility of natural circulation reactor design. The instability is classified as a type of density wave instability induced by flashing. A detailed stability study is performed focusing on flashing induced instability under natural circulation condition. Various flashing phenomena have been studied and a mechanistic flashing model has been proposed and improved using a relaxation method. The developed relaxation flashing model can be applied to general two-phase non-equilibrium phenomena.

Zheng, Dong

2001-07-01

74

Rankine bottoming cycle safety analysis. Final report  

SciTech Connect

Vector Engineering Inc. conducted a safety and hazards analysis of three Rankine Bottoming Cycle Systems in public utility applications: a Thermo Electron system using Fluorinal-85 (a mixture of 85 mole % trifluoroethanol and 15 mole % water) as the working fluid; a Sundstrand system using toluene as the working fluid; and a Mechanical Technology system using steam and Freon-II as the working fluids. The properties of the working fluids considered are flammability, toxicity, and degradation, and the risks to both plant workers and the community at large are analyzed.

Lewandowski, G.A.

1980-02-01

75

ESSAA: Embedded system safety analysis assistant  

NASA Technical Reports Server (NTRS)

The Embedded System Safety Analysis Assistant (ESSAA) is a knowledge-based tool that can assist in identifying disaster scenarios. Imbedded software issues hazardous control commands to the surrounding hardware. ESSAA is intended to work from outputs to inputs, as a complement to simulation and verification methods. Rather than treating the software in isolation, it examines the context in which the software is to be deployed. Given a specified disasterous outcome, ESSAA works from a qualitative, abstract model of the complete system to infer sets of environmental conditions and/or failures that could cause a disasterous outcome. The scenarios can then be examined in depth for plausibility using existing techniques.

Wallace, Peter; Holzer, Joseph; Guarro, Sergio; Hyatt, Larry

1987-01-01

76

Short course on system safety analysis  

SciTech Connect

This course provides and introduction to methods generally used in safety analysis and accident investigation. It is a non-mathematical approach, directed toward a casual user. The participant will learn techniques allowing them to dissect a system or incident in order identify real or potential safety problems. These techniques will be applied to analyze events which have occurred within DOE facilities. As a manager or staff person with general oversight responsibilities, the participant should gain an awareness of the big picture and not just ``dig for facts.`` This can be accomplished by being alert and responsive to the atmosphere and condition of the plant; mood and impression of the worker and the behavioral climate. The techniques taught in the course can be used to identify critical areas or indicators. These indicators will signal problems before the ``facts`` will. Analysis techniques taught are used to gauge the breadth of the ``forest`` and not necessarily to identify the trees. For this course includes a technical background with experience in a chemical processing operations and a knowledge of basic chemistry and engineering is desirable. The course should help in a present or future assignment in an oversight role.

Sudmann, R.H.

1992-06-01

77

Short course on system safety analysis  

SciTech Connect

This course provides and introduction to methods generally used in safety analysis and accident investigation. It is a non-mathematical approach, directed toward a casual user. The participant will learn techniques allowing them to dissect a system or incident in order identify real or potential safety problems. These techniques will be applied to analyze events which have occurred within DOE facilities. As a manager or staff person with general oversight responsibilities, the participant should gain an awareness of the big picture and not just dig for facts.'' This can be accomplished by being alert and responsive to the atmosphere and condition of the plant; mood and impression of the worker and the behavioral climate. The techniques taught in the course can be used to identify critical areas or indicators. These indicators will signal problems before the facts'' will. Analysis techniques taught are used to gauge the breadth of the forest'' and not necessarily to identify the trees. For this course includes a technical background with experience in a chemical processing operations and a knowledge of basic chemistry and engineering is desirable. The course should help in a present or future assignment in an oversight role.

Sudmann, R.H.

1992-01-01

78

Kernel analysis of partial least squares (PLS) regression models.  

PubMed

An analytical technique based on kernel matrix representation is demonstrated to provide further chemically meaningful insight into partial least squares (PLS) regression models. The kernel matrix condenses essential information about scores derived from PLS or principal component analysis (PCA). Thus, it becomes possible to establish the proper interpretation of the scores. A PLS model for the total nitrogen (TN) content in multiple Thai fish sauces is built with a set of near-infrared (NIR) transmittance spectra of the fish sauce samples. The kernel analysis of the scores effectively reveals that the variation of the spectral feature induced by the change in protein content is substantially associated with the total water content and the protein hydration. Kernel analysis is also carried out on a set of time-dependent infrared (IR) spectra representing transient evaporation of ethanol from a binary mixture solution of ethanol and oleic acid. A PLS model to predict the elapsed time is built with the IR spectra and the kernel matrix is derived from the scores. The detailed analysis of the kernel matrix provides penetrating insight into the interaction between the ethanol and the oleic acid. PMID:21513599

Shinzawa, Hideyuki; Ritthiruangdej, Pitiporn; Ozaki, Yukihiro

2011-05-01

79

Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age  

PubMed Central

Epilepsy is a common neurological disorder in the pediatric population, affecting up to one percent of children, and for which the mainstay of treatment is anticonvulsant medication. Despite the frequent use of anticonvulsant drugs, remarkably little is known about the safety and efficacy of most of these medications in the pediatric epilepsy population. Of 34 anticonvulsants currently approved for use by the US Food and Drug Administration (FDA), only 13 have been approved for use in children. Although infants and young children are disproportionately affected by epilepsy, there are currently only three anticonvulsant medications that have been specifically evaluated and approved for use in children younger than 2 years of age. In 2012, the FDA approved levetiracetam as an adjunctive treatment for partial onset seizures in infants and children from one month of age. Here we review the available data on levetiracetam in the pediatric epilepsy population. We first discuss the pharmacological profile of levetiracetam, including its mechanism of action, formulations and dosing, and pharmacokinetics in children. We then review the available efficacy, safety, and tolerability data in children from one month of age with partial onset seizures. We conclude that the current data leading to the approval of levetiracetam for use in infants and children with partial onset seizures is encouraging, although more work needs to be done before definitive conclusions can be drawn about the efficacy of levetiracetam across different pediatric age groups.

Cormier, Justine; Chu, Catherine J

2013-01-01

80

Partial Means in the Economic Risk Analysis of Projects  

Microsoft Academic Search

Partial means constitute a new measure of economic risk that unifies and subsumes many less general measures. The partial mean of a random variable is its expected value conditioned on its falling within a given range. For a random variable such as the present worth of a return with uncertain timings, partial means are directly usable to discretize a continuum

James R. Buck; Ronald G. Askin

1986-01-01

81

Partially observable Markov decision processes and performance sensitivity analysis.  

PubMed

The sensitivity-based optimization of Markov systems has become an increasingly important area. From the perspective of performance sensitivity analysis, policy-iteration algorithms and gradient estimation methods can be directly obtained for Markov decision processes (MDPs). In this correspondence, the sensitivity-based optimization is extended to average reward partially observable MDPs (POMDPs). We derive the performance-difference and performance-derivative formulas of POMDPs. On the basis of the performance-derivative formula, we present a new method to estimate the performance gradients. From the performance-difference formula, we obtain a sufficient optimality condition without the discounted reward formulation. We also propose a policy-iteration algorithm to obtain a nearly optimal finite-state-controller policy. PMID:19022734

Li, Yanjie; Yin, Baoqun; Xi, Hongsheng

2008-12-01

82

Poles of the Zagreb analysis partial-wave T matrices  

SciTech Connect

The Zagreb analysis partial-wave T matrices included in the Review of Particle Physics[by the Particle Data Group (PDG)] contain Breit-Wigner parameters only. As the advantages of pole over Breit-Wigner parameters in quantifying scattering matrix resonant states are becoming indisputable, we supplement the original solution with the pole parameters. Because of an already reported numeric error in the S{sub 11} analytic continuation [Batinicet al., Phys. Rev. C 57, 1004(E) (1997); arXiv:nucl-th/9703023], we declare the old BATINIC 95 solution, presently included by the PDG, invalid. Instead, we offer two new solutions: (A) corrected BATINIC 95 and (B) a new solution with an improved S{sub 11} {pi}N elastic input. We endorse solution (B).

Batinic, M.; Ceci, S.; Svarc, A.; Zauner, B. [Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb (Croatia)

2010-09-15

83

Partial wave analysis of ?(2S)?pp¯?  

NASA Astrophysics Data System (ADS)

Using a sample of 1.06×108 ?(2S) events collected with the BESIII detector at BEPCII, the decay ?(2S)?pp¯? is studied. A partial wave analysis determines that the intermediate state N(1535) with a mass of 1524±5-4+10MeV/c2 and a width of 130-24-10+27+57MeV/c2 is dominant in the decay; the product branching fraction is determined to be B(?(2S)?N(1535)p¯)×B(N(1535)?p?)+c.c.=(5.2±0.3-1.2+3.2)×10-5. Furthermore, the branching fraction of ?(2S)?pp¯? is measured to be (6.4±0.2±0.6)×10-5. Here, the first error is statistical and the second is systematic.

Ablikim, M.; Achasov, M. N.; Albayrak, O.; Ambrose, D. J.; An, F. F.; An, Q.; Bai, J. Z.; Baldini Ferroli, R.; Ban, Y.; Becker, J.; Bennett, J. V.; Bertani, M.; Bian, J. M.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Bytev, V.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X.; Chen, Y. B.; Cheng, H. P.; Chu, Y. P.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J. P.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; Ding, W. M.; Ding, Y.; Dong, L. Y.; Dong, M. Y.; Du, S. X.; Fang, J.; Fang, S. S.; Fava, L.; Feng, C. Q.; Friedel, P.; Fu, C. D.; Fu, J. L.; Fuks, O.; Gao, Y.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, T.; Guo, Y. P.; Han, Y. L.; Harris, F. A.; He, K. L.; He, M.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Huang, G. M.; Huang, G. S.; Huang, J. S.; Huang, L.; Huang, X. T.; Huang, Y.; Huang, Y. P.; Hussain, T.; Ji, C. S.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. L.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jing, F. F.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Kopf, B.; Kornicer, M.; Kühn, W.; Lai, W.; Lange, J. S.; Larin, P.; Leyhe, M.; Li, C. H.; Li, Cheng; Li, Cui; Li, D. M.; Li, F.; Li, G.; Li, H. B.; Li, J. C.; Li, K.; Li, Lei; Li, Q. J.; Li, S. L.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, X. R.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, X. T.; Lin, D.; Liu, B. J.; Liu, C. L.; Liu, C. X.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H.; Liu, H. B.; Liu, H. H.; Liu, H. M.; Liu, H. W.; Liu, J. P.; Liu, K.; Liu, K. Y.; Liu, Kai; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lu, G. R.; Lu, H. J.; Lu, J. G.; Lu, Q. W.; Lu, X. R.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lv, M.; Ma, C. L.; Ma, F. C.; Ma, H. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. Y.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Moeini, H.; Morales Morales, C.; Moriya, K.; Muchnoi, N. Yu.; Muramatsu, H.; Nefedov, Y.; Nicholson, C.; Nikolaev, I. B.; Ning, Z.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Park, J. W.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Ping, J. L.; Ping, R. G.; Poling, R.; Prencipe, E.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Rong, G.; Ruan, X. D.; Sarantsev, A.; Schaefer, B. D.; Shao, M.; Shen, C. P.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, W. M.; Song, X. Y.; Spataro, S.; Spruck, B.; Sun, D. H.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tian, H. L.; Toth, D.; Ullrich, M.; Uman, I.; Varner, G. S.; Wang, B. Q.; Wang, D.; Wang, D. Y.; Wang, J. X.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q. J.; Wang, S. G.; Wang, X. F.; Wang, X. L.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wei, D. H.; Wei, J. B.; Weidenkaff, P.; Wen, Q. G.; Wen, S. P.; Werner, M.; Wiedner, U.; Wu, L. H.; Wu, N.; Wu, S. X.; Wu, W.; Wu, Z.; Xia, L. G.; Xia, Y. X.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, G. M.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Xu, Z. R.; Xue, F.; Xue, Z.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. X.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yu, B. X.; Yu, C. X.; Yu, H. W.; Yu, J. S.; Yu, S. P.; Yuan, C. Z.; Yuan, Y.; Zafar, A. A.; Zallo, A.; Zang, S. L.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, LiLi; Zhang, R.; Zhang, S. H.; Zhang, X. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhang, Zhenghao; Zhao, G.; Zhao, H. S.; Zhao, J. W.; Zhao, K. X.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, X. H.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhu, C.; Zhu, K.; Zhu, K. J.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. M.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.

2013-08-01

84

Evaluation of safety assessment methodologies in Rocky Flats Risk Assessment Guide (1985) and Building 707 Final Safety Analysis Report (1987)  

Microsoft Academic Search

FSARs. Rockwell International, as operating contractor at the Rocky Flats plant, conducted a safety analysis program during the 1980s. That effort resulted in Final Safety Analysis Reports (FSARs) for several buildings, one of them being the Building 707 Final Safety Analysis Report, June 87 (707FSAR) and a Plant Safety Analysis Report. Rocky Flats Risk Assessment Guide, March 1985 (RFRAG85) documents

B. Walsh; C. Fisher; G. Zigler; R. A. Clark

1990-01-01

85

Improved Range Safety Analysis for Space Vehicles Using Range Safety Template Toolkit  

NASA Astrophysics Data System (ADS)

This paper discusses an alternative to traditional methodologies for space launch and re-entry vehicle range safety analysis using the Range Safety Template Toolkit (RSTT), developed by Australia's Defense Science and Technology Organization (DSTO) in partnership with Aerospace Concepts Pty Ltd. RSTT offers rapid generation of mission-specific safety templates that comply with internationally-recognized standards for range risk criteria. Compared to some traditional methods, RSTT produces more accurate assessments of risk to personnel and infrastructure. This provides range operators with greater confidence in the range safety products, enhancing their ability to rigorously manage safety on their ranges. RSTT also offers increased precision of risk analysis and iteration of mission design allowing greater flexibility in planning range operations with rapid feedback on the safety impact of mission changes. These concepts are explored through examples involving a suborbital sounding rocket, demonstrating how traditional range safety assumptions may be reassessed using the RSTT robust probabilistic methodology.

Tisato, J.; Vuletich, I.; Brett, M.; Williams, W.; Wilson, S.

2012-01-01

86

Federal and State Regulations of Food and Product Safety and Quality: A Selected, Partially Annotated Bibliography.  

National Technical Information Service (NTIS)

The bibliography contains citations of research on Federal and State regulations of food product safety and quality. The annotated portion emphasizes articles on jurisdictional conflict between Federal and State regulations of food products and the use of...

J. A. Caswell

1988-01-01

87

Federal and State Regulations of Food Product Safety and Quality. A Selected, Partially Annotated Bibliography.  

National Technical Information Service (NTIS)

The bibliography contains citations of research on Federal and State regulations of food product safety and quality. The annotated portion emphasizes articles on jurisdictional conflict between Federal and State regulations of food products and the use of...

J. A. Caswell

1988-01-01

88

UNIPALS: Software for Principal Components Analysis and Partial Least Squares Regression.  

National Technical Information Service (NTIS)

Software for the analysis of multivariate chemical data by principal components and partial least squares methods is included on disk. The methods extract latent variables from the chemical data with the UNIversal PArtial Lease Squares (UNIPALS) algorithm...

W. G. Glen M. Sarker W. J. Dunn D. R. Scott

1990-01-01

89

Correlates of safety outcomes during patient ambulance transport: a partial test of the Haddon matrix.  

PubMed

The Haddon Matrix has been cited in a recent review of patient safety as a useful framework for understanding Emergency Medical Services (EMS) provider and patient injury prevention and safety during ambulance response and transport. The research goal of this study was to test part of the Haddon matrix, specifically variables within the pre-event host and event host cells, for explaining three multi-item ambulance-related safety outcomes: i.e., anticipated use of safety equipment, securing the patient, and securing the equipment. Complete study data were available for 648 EMS professionals who responded to the 2004 Longitudinal Emergency Medical Technician Attributes and Demographic Study (LEADS) survey. Overall very modest results were found. Specific findings indicated that EMS professionals with: lower perceived health, greater intrinsic satisfaction, more time in the patient compartment of an ambulance, and greater seatbelt use had higher anticipated use of ambulance safety equipment. For the patient being secured in an ambulance, the extremely high mean/low score variance resulted in only extrinsic satisfaction having a significant positive association. Finally, female EMS professionals, those more extrinsically satisfied, not being involved in a prior ambulance accident, and greater seatbelt use were related to higher frequency of securing ambulance equipment during patient transport. PMID:22968779

Blau, Gary; Chapman, Susan; Boyer, Ed; Flanagan, Richard; Lam, Than; Monos, Christopher

2012-01-01

90

Modeling Controller Tasks for Safety Analysis  

NASA Technical Reports Server (NTRS)

As control systems become more complex, the use of automated control has increased. At the same time, the role of the human operator has changed from primary system controller to supervisor or monitor. Safe design of the human computer interaction becomes more difficult. In this paper, we present a visual task modeling language that can be used by system designers to model human-computer interactions. The visual models can be translated into SpecTRM-RL, a blackbox specification language for modeling the automated portion of the control system. The SpecTRM-RL suite of analysis tools allow the designer to perform formal and informal safety analyses on the task model in isolation or integrated with the rest of the modeled system.

Brown, Molly; Leveson, Nancy G.

1998-01-01

91

Evaluation of accuracy in partial volume analysis of small objects  

NASA Astrophysics Data System (ADS)

Accurate and robust assessment of quantitative parameters is a key issue in many fields of medical image analysis, and can have a direct impact on diagnosis and treatment monitoring. Especially for the analysis of small structures such as focal lesions in patients with MS, the finite spatial resolution of imaging devices is often a limiting factor that results in a mixture of different tissue types. We propose a new method that allows an accurate quantification of medical image data, focusing on a dedicated model for partial volume (PV) artifacts. Today, a widely accepted model assumption is that of a uniformly distributed linear mixture of pure tissues. However, several publications have clearly shown that this is not an appropriate choice in many cases. We propose a generalization of current PV models based on the Beta distribution, yielding a more accurate quantification. Furthermore, we present a new classification scheme. Prior knowledge obtained from a set of training data allows a robust initial estimate of the proper model parameters, even in cases of objects with predominant PV artifacts. A maximum likelihood based clustering algorithm is employed, resulting in a robust volume estimate. Experiments are carried out on more than 100 stylized software phantoms as well as on realistic phantom data sets. A comparison with current mixture models shows the capabilities of our approach.

Rexilius, Jan; Peitgen, Heinz-Otto

2008-04-01

92

Stress analysis of a partially slotted intramedullary nail.  

PubMed

A finite element analysis of the Arbeitsgemeinschaft für Osteosynthesefragen/Association for the Study of Internal Fixation (AO/ASIF) intramedullary femoral nail was performed to study the failure of the nail from circumferential cracking near the slot tip. These failures are evidently the result of a stress-concentrating effect owing to the partially slotted nail design. Several finite element models were created of the proximal one-fourth of the nail. One model of the nail incorporated the cloverleaf profile as it is presently manufactured, and one had a circular cross section. An additional three models were created with alternative slot-tip geometries: a narrowed slot, a tapered slot, and a widened slot. Antero-posterior (AP) and medio-lateral (ML) bending loads and torsion loads were applied in two fundamentally different loading modes: (1) loads that were applied on both sides of the slot tip (spanned); and (2) loads that were self-equilibrating distal to the slot tip (non-spanned). For the load cases studied, for all models, the stresses predicted from the finite element models were locally highest at the junction between the open and closed cross sections. Alternative slot-tip shapes had a marked effect on the predicted stresses, in one case reducing maximum stress by 40%. However, no alternative slot tip shape was uniformly superior for all load cases. Therefore, until the in vivo loading modes are known more precisely, an alternative slot-tip shape cannot be proposed. PMID:6527162

Beaupré, G S; Schneider, E; Perren, S M

1984-01-01

93

Biosensors for functional food safety and analysis.  

PubMed

The importance of safety and functionality analysis of foodstuffs and raw materials is supported by national legislations and European Union (EU) directives concerning not only the amount of residues of pollutants and pathogens but also the activity and content of food additives and the health claims stated on their labels. In addition, consumers' awareness of the impact of functional foods' on their well-being and their desire for daily healthcare without the intake pharmaceuticals has immensely in recent years. Within this picture, the availability of fast, reliable, low cost control systems to measure the content and the quality of food additives and nutrients with health claims becomes mandatory, to be used by producers, consumers and the governmental bodies in charge of the legal supervision of such matters. This review aims at describing the most important methods and tools used for food analysis, starting with the classical methods (e.g., gas-chromatography GC, high performance liquid chromatography HPLC) and moving to the use of biosensors-novel biological material-based equipments. Four types of bio-sensors, among others, the novel photosynthetic proteins-based devices which are more promising and common in food analysis applications, are reviewed. A particular highlight on biosensors for the emerging market of functional foods is given and the most widely applied functional components are reviewed with a comprehensive analysis of papers published in the last three years; this report discusses recent trends for sensitive, fast, repeatable and cheap measurements, focused on the detection of vitamins, folate (folic acid), zinc (Zn), iron (Fe), calcium (Ca), fatty acids (in particular Omega 3), phytosterols and phytochemicals. A final market overview emphasizes some practical aspects ofbiosensor applications. PMID:21520718

Lavecchia, Teresa; Tibuzzi, Arianna; Giardi, Maria Teresa

2010-01-01

94

Chromosomal-array analysis reveals partial 11q duplication and partial 12p deletion in a mildly affected case.  

PubMed

Partial trisomy 11q is a rare syndrome and may be observed due to an intra-chromosomal duplication or an inter-chromosomal insertion. The deletions of the short arm of chromosome 12 are also uncommon structural aberrations. Only a small fraction of structural chromosome anomalies are related to the unbalanced progeny of balanced translocation carrier parents. We here report on a 10-month-old baby boy who shows a very mild phenotype related to unique chromosomal abnormality, partial trisomy of 11q, and partial monosomy of 12p, due to the maternal balanced reciprocal translocation (11;12). The proband showed a 49.64?Mb duplication of 11q14.1-q25 and 0.44?Mb deletion of 12p13.33 in chromosomal array analysis. Since it is known that the duplications may cause a milder phenotype than deletions. Dysmorphic facial features, minor cardiac anomalies, respiratory distress, central nervous system anomalies, and psychomotor delay observed in the patient was similar to the reported pure 11q duplication cases, while behavioral problems observed in pure monosomy 12p cases could not be evaluated due to the young age of the patient. Phenotype-genotype correlation will be discussed in view of all the reported pure partial 11q trisomies and pure partial 12p deletion cases. PMID:24677787

Tu?, Esra; Yirmibe? Karao?uz, Meral; Kayhan, Gülsüm; Ergün, Mehmet Ali; Perçin, Ferda E

2014-07-01

95

Analysis of partial and complete protection in malaria cohort studies  

PubMed Central

Background Malaria transmission is highly heterogeneous and analysis of incidence data must account for this for correct statistical inference. Less widely appreciated is the occurrence of a large number of zero counts (children without a malaria episode) in malaria cohort studies. Zero-inflated regression methods provide one means of addressing this issue, and also allow risk factors providing complete and partial protection to be disentangled. Methods Poisson, negative binomial (NB), zero-inflated Poisson (ZIP) and zero-inflated negative binomial (ZINB) regression models were fitted to data from two cohort studies of malaria in children in Ghana. Multivariate models were used to understand risk factors for elevated incidence of malaria and for remaining malaria-free, and to estimate the fraction of the population not at risk of malaria. Results ZINB models, which account for both heterogeneity in individual risk and an unexposed sub-group within the population, provided the best fit to data in both cohorts. These approaches gave additional insight into the mechanism of factors influencing the incidence of malaria compared to simpler approaches, such as NB regression. For example, compared to urban areas, rural residence was found to both increase the incidence rate of malaria among exposed children, and increase the probability of being exposed. In Navrongo, 34% of urban residents were estimated to be at no risk, compared to 3% of rural residents. In Kintampo, 47% of urban residents and 13% of rural residents were estimated to be at no risk. Conclusion These results illustrate the utility of zero-inflated regression methods for analysis of malaria cohort data that include a large number of zero counts. Specifically, these results suggest that interventions that reach mainly urban residents will have limited overall impact, since some urban residents are essentially at no risk, even in areas of high endemicity, such as in Ghana.

2013-01-01

96

Safety analysis of the nuclear chemistry Building 151  

SciTech Connect

This report summarizes the results of a safety analysis that was done on Building 151. The report outlines the methodology, the analysis, and the findings that led to the low hazard classification. No further safety evaluation is indicated at this time. 5 tables.

Kvam, D.

1984-06-29

97

Effectiveness, Tolerability, and Safety of Topiramate in Children with Partial-Onset Seizures  

Microsoft Academic Search

Summary: Purpose: Children with partial-onset seizures, with or without secondary generalization, participating in a double-blind, placebo-controlled trial of topiramate (TPM) as adjunctive therapy were eligible to participate in an open-label, long-term extension study. Methods: A total of 83 children (mean age, 9 years) contin- ued long-term open-label TPM therapy in which the dosages of TPM and concomitant antiepileptic drugs (AEDs)

Frank Ritter; Tracy A. Glauser; Roy D. Elterman; Elaine Wyllie

2000-01-01

98

Robotic Partial Nephrectomy for Renal Tumors Larger than 4 cm: A Systematic Review and Meta-analysis  

PubMed Central

Background With the establishment of minimally invasive surgery in society, the robot has been increasingly widely used in the urologic field, including in partial nephrectomy. This study aimed to comprehensively summarize the currently available evidence on the feasibility and safety of robotic partial nephrectomy for renal tumors of >4 cm. Method and Findings An electronic database search of PubMed, Scopus, Web of Science, and the Cochrane Library was performed. This systematic review and meta-analysis was based on all relevant studies that assessed robotic partial nephrectomy for renal tumors of >4 cm. Five studies were included. The meta-analysis involved 3 studies from 11 institutions including 154 patients, while the narrative review involved the remaining 2 studies from 5 institutions including 64 patients. In the meta-analysis, the mean ischemic time, operation time, and console time was 28, 319, and 189 minutes, respectively. The estimated blood loss and length of stay was 317 ml and 3.8 days, respectively. The rates of conversion, positive margins, intraoperative complications, postoperative complications, hilar clamping, and collecting system repair were 7.0%, 3.5%, 7.0%, 9.8%, 93.9%, and 47.5%, respectively. The narrative review showed results similar to those of the meta-analysis. Conclusions Robotic partial nephrectomy is feasible and safe for renal tumors of >4 cm with an acceptable warm ischemic time, positive margin rate, conversion rate, complication rate, operation time, estimated blood loss, and length of stay.

Fan, Xinxiang; Xu, Kewei; Han, Jinli; Huang, Hai; Liu, Hao; Dong, Wen; Huang, Jian; Lin, Tianxin

2013-01-01

99

Partial differential equation transform -- Variational formulation and Fourier analysis  

PubMed Central

Nonlinear partial differential equation (PDE) models are established approaches for image/signal processing, data analysis and surface construction. Most previous geometric PDEs are utilized as low-pass filters which give rise to image trend information. In an earlier work, we introduced mode decomposition evolution equations (MoDEEs), which behave like high-pass filters and are able to systematically provide intrinsic mode functions (IMFs) of signals and images. Due to their tunable time-frequency localization and perfect reconstruction, the operation of MoDEEs is called a PDE transform. By appropriate selection of PDE transform parameters, we can tune IMFs into trends, edges, textures, noise etc., which can be further utilized in the secondary processing for various purposes. This work introduces the variational formulation, performs the Fourier analysis, and conducts biomedical and biological applications of the proposed PDE transform. The variational formulation offers an algorithm to incorporate two image functions and two sets of low-pass PDE operators in the total energy functional. Two low-pass PDE operators have different signs, leading to energy disparity, while a coupling term, acting as a relative fidelity of two image functions, is introduced to reduce the disparity of two energy components. We construct variational PDE transforms by using Euler-Lagrange equation and artificial time propagation. Fourier analysis of a simplified PDE transform is presented to shed light on the filter properties of high order PDE transforms. Such an analysis also offers insight on the parameter selection of the PDE transform. The proposed PDE transform algorithm is validated by numerous benchmark tests. In one selected challenging example, we illustrate the ability of PDE transform to separate two adjacent frequencies of sin(x) and sin(1.1x). Such an ability is due to PDE transform’s controllable frequency localization obtained by adjusting the order of PDEs. The frequency selection is achieved either by diffusion coefficients or by propagation time. Finally, we explore a large number of practical applications to further demonstrate the utility of proposed PDE transform.

Wang, Yang; Wei, Guo-Wei; Yang, Siyang

2011-01-01

100

Preliminary Safety Analysis of the Gorleben Site: Overview - 13298  

SciTech Connect

The project preliminary safety analysis of the Gorleben site started in 2010 and is based on the safety requirements for heat generating radioactive waste released from the German Federal Ministry for Environment, natural conservation and nuclear safety. The project consists of several tasks: the database defining the geology of Gorleben and the composition of the waste to be disposed of, the safety and demonstration concept, the repository concepts, the scenario analysis, the system analysis with long-term safety assessment and the synthesis. The overall synthesis indicates presently the compatibility of a repository in Gorleben with the safety requirements. The application of the method for a site selection process is still under evaluation. (authors)

Bracke, G.; Fischer-Appelt, K. [GRS mbH, Schwertnergasse 1, 50677 Cologne (Germany)] [GRS mbH, Schwertnergasse 1, 50677 Cologne (Germany); Baltes, B. [B. Baltes, Paul Kaussen Str. 17a, 52477 Alsdorf (Germany)] [B. Baltes, Paul Kaussen Str. 17a, 52477 Alsdorf (Germany)

2013-07-01

101

TA-55 Final Safety Analysis Report Comparison Document and DOE Safety Evaluation Report Requirements  

SciTech Connect

This document provides an overview of changes to the currently approved TA-55 Final Safety Analysis Report (FSAR) that are included in the upgraded FSAR. The DOE Safety Evaluation Report (SER) requirements that are incorporated into the upgraded FSAR are briefly discussed to provide the starting point in the FSAR with respect to the SER requirements.

Alan Bond

2001-04-01

102

Applications of Decision Analysis to Occupational Health and Safety Problems.  

National Technical Information Service (NTIS)

This report presents an evaluation of the methodologies of decision analysis as aids in managing the occupational health and safety activities of an organization. Various techniques from the field of decision analysis are evaluated in terms of the philoso...

J. S. Dyer

1978-01-01

103

Application of Factor Restructuring Analysis in Enterprise Safety Culture Evaluation  

NASA Astrophysics Data System (ADS)

The enterprise safety culture index system, which mainly consists of enterprise decision-making level, management level, implementation level, and external environmental factor, is constructed based on human errors theory. Then, a corresponding enterprise safety culture evaluation model adapting to the characteristics of this index system is presented with consideration of the constraint condition of data and by taking full use of the advantages of factor system restructuring analysis and principal component analysis in data processing; The model provides an operable way for evaluating the enterprise safety culture. Further, the model is to make up for the gaps of enterprise safety culture evaluation.

Wang, Yihong; Xia, Liming; Pan, Jinshuang; Zong, Hengheng

104

Analysis of US child care safety regulations.  

PubMed Central

BACKGROUND: With 1.9 million US children cared for in organized group child care, the safety of these children is a public health concern. In the absence of federal policy, each state has developed its own day care safety regulations. METHODS: After creating a set of 36 criteria from three sets of national guidelines, we assessed the safety regulations of 45 states. With a mailed survey of state day care regulatory personnel, we examined the processes of formulating and implementing safety policy in 47 states. RESULTS: For 24 of the 36 items, more than half the states' regulations were below the criteria or failed to mention the topic. Most notable is the inattention to playground safety, choking hazards, and firearms. CONCLUSION: The uneven quality of regulations may be a reflection of a regulatory process that is fragmented, with many different groups sharing authority and with limited involvement of injury prevention specialists.

Runyan, C W; Gray, D E; Kotch, J B; Kreuter, M W

1991-01-01

105

Lunar mission safety and rescue: Hazards analysis and safety requirements  

NASA Technical Reports Server (NTRS)

The results are presented of the hazards analysis which was concerned only with hazards to personnel and not with loss of equipment or property. Hazards characterization includes the definition of a hazard, the hazard levels, and the hazard groups. The analysis methodology is described in detail. The methodology was used to prepare the top level functional flow diagrams, to perform the first level hazards assessment, and to develop a list of conditions and situations requiring individual hazard studies. The 39 individual hazard study results are presented in total.

1971-01-01

106

Simultaneous quantitative analysis of overlapping spectrophotometric signals using wavelet multiresolution analysis and partial least squares  

Microsoft Academic Search

The mathematical bases and program algorithms of discrete wavelet transform (DWT), multiresolution and Mallat’s pyramid algorithm were described. The multiresolution analysis (MRA) based on Daubechies orthogonal wavelet basis was studied as a tool for removing noise and irrelevant information from spectrophotometric spectra. After wavelet MRA pre-treatment, eight error functions were calculated for deducing the number of factors. A partial least

Shouxin Ren; Ling Gao

2000-01-01

107

Moon manned missions radiation safety analysis  

NASA Astrophysics Data System (ADS)

An analysis is performed on the radiation environment found on the surface of the Moon, and applied to different possible lunar base mission scenarios. An optimization technique has been used to obtain mission scenarios minimizing the astronaut radiation exposure and at the same time controlling the effect of shielding, in terms of mass addition and material choice, as a mission cost driver. The optimization process has been realized through minimization of mass along all phases of a mission scenario, in terms of time frame (dates, transfer time length and trajectory, radiation environment), equipment (vehicles, in terms of shape, volume, onboard material choice, size and structure), location (if in space, on the surface, inside or outside a certain habitats), crew characteristics (number, gender, age, tasks) and performance required (spacecraft and habitat volumes), radiation exposure annual and career limit constraint (from NCRP 132), and implementation of the ALARA principle (shelter from the occurrence of Solar Particle Events). On the lunar surface the most important contribution to radiation exposure is given by background Galactic Cosmic Rays (GCR) particles, mostly protons, alpha particles, and some heavy ions, and by locally induced particles, mostly neutrons, created by the interaction between GCR and surface material and emerging from below the surface due to backscattering processes. In this environment manned habitats are to host future crews involved in the construction and/or in the utilization of moon based infrastructure. Three different kinds of lunar missions are considered in the analysis, Moon Base Construction Phase, during which astronauts are on the surface just to build an outpost for future resident crews, Moon Base Outpost Phase, during which astronaut crews are resident but continuing exploration and installation activities, and Moon Base Routine Phase, with long-term shifting resident crews. In each scenario various kinds of habitats, from very simple shelters to more complex bases, are considered in full detail (e.g., shape, thickness, materials, etc) with considerations of various shielding strategies. In this first analysis all the shape considered are cylindrical or composed of combination of cylinders. Moreover, a radiation safety analysis of more future possible habitats like lava tubes has been also performed.

Tripathi, R. K.; Wilson, J. W.; de Anlelis, G.; Badavi, F. F.

108

An empirical investigation of partial effect sizes in meta-analysis of correlational data.  

PubMed

The partial correlation and the semi-partial correlation can be seen as measures of partial effect sizes for the correlational family. Thus, both indices have been used in the meta-analysis literature to represent the relationship between an outcome and a predictor of interest, controlling for the effect of other variables in the model. This article evaluates the accuracy of synthesizing these two indices under different situations. Both partial correlation and the semi-partial correlation appear to behave as expected with respect to bias and root mean squared error (RMSE). However, the partial correlation seems to outperform the semi-partial correlation regarding Type I error of the homogeneity test (Q statistic). Although further investigation is needed to fully understand the impact of meta-analyzing partial effect sizes, the current study demonstrates the accuracy of both indices. PMID:24838020

Aloe, Ariel M

2014-01-01

109

SNF fuel retrieval sub project safety analysis document  

SciTech Connect

This safety analysis is for the SNF Fuel Retrieval (FRS) Sub Project. The FRS equipment will be added to K West and K East Basins to facilitate retrieval, cleaning and repackaging the spent nuclear fuel into Multi-Canister Overpack baskets. The document includes a hazard evaluation, identifies bounding accidents, documents analyses of the accidents and establishes safety class or safety significant equipment to mitigate accidents as needed.

BERGMANN, D.W.

1999-02-24

110

Analysis of microgravity space experiments Space Shuttle programmatic safety requirements  

NASA Technical Reports Server (NTRS)

This report documents the results of an analysis of microgravity space experiments space shuttle programmatic safety requirements and recommends the creation of a Safety Compliance Data Package (SCDP) Template for both flight and ground processes. These templates detail the programmatic requirements necessary to produce a complete SCDP. The templates were developed from various NASA centers' requirement documents, previously written guidelines on safety data packages, and from personal experiences. The templates are included in the back as part of this report.

Terlep, Judith A.

1996-01-01

111

Safety analysis report for the Waste Storage Facility. Revision 2  

SciTech Connect

This safety analysis report outlines the safety concerns associated with the Waste Storage Facility located in the Radioactive Waste Management Complex at the Idaho National Engineering Laboratory. The three main objectives of the report are: define and document a safety basis for the Waste Storage Facility activities; demonstrate how the activities will be carried out to adequately protect the workers, public, and environment; and provide a basis for review and acceptance of the identified risk that the managers, operators, and owners will assume.

Bengston, S.J.

1994-05-01

112

Safety analysis report 231-Z Building  

SciTech Connect

This report provides an intensive review of the nuclear safety of the operation of the 231-Z Building. For background information complete descriptions of the floor plan, building services, alarm systems, and glove box systems are included in this report. In addition, references are included to The Plutonium Laboratory Radiation Work Procedures, Safety Guides, 231-Z Operating Procedures Manual and Nuclear Materials accountability Procedures. Engineered and administrative features contribute to the overall safety of personnel, the building, and environs. The consequences of credible incidents were considered and are discussed.

Powers, C.S.

1989-03-01

113

Safety Analysis for Vented Dust Explosions.  

National Technical Information Service (NTIS)

Below some critical particle size, magnesium powder is pyrophoric in air. Techniques for producing fine magnesium powder therefore require use of an inert atmosphere in an enclosed system. For added safety, these systems are set up in strong, vented explo...

J. J. Kulesz W. E. Baker

1986-01-01

114

Efficacy and safety of extended-release oxcarbazepine (Oxtellar XR(TM)) as adjunctive therapy in patients with refractory partial-onset seizures: a randomized controlled trial  

PubMed Central

Objective To evaluate the efficacy, tolerability, and safety of once-daily 1200 mg and 2400 mg SPN-804 (Oxtellar XR™, Supernus Pharmaceuticals), an extended-release tablet formulation of oxcarbazepine (OXC), added to 1-3 concomitant antiepileptic drugs (AEDs) in adults with refractory partial-onset seizures, with or without secondary generalization. Methods The Prospective, Randomized Study of OXC XR in Subjects with Partial Epilepsy Refractory (PROSPER) study was a multinational, randomized, double-blind, parallel-group Phase 3 study. The primary efficacy endpoint was median percent reduction from baseline in monthly (28-day) seizure frequency for the 16-week double-blind treatment period in the intent-to-treat (ITT) population with analyzable seizure data. Other efficacy analyses included proportion of patients with ? 50% seizure reduction, proportion of patients seizure free, and the relationship between clinical response and plasma concentration. Results Median percent reduction was -28.7% for placebo, ?38.2% (P = 0.08 vs placebo) for once-daily SPN-804 1200 mg, and ?42.9% (P = 0.003) for SPN-804 2400 mg. Responder rates were 28.1%, 36.1% (P = 0.08), and 40.7% (P = 0.02); 16-week seizure-free rates in a pragmatic ITT analysis were 3.3%, 4.9% (P = 0.59), and 11.4% (P = 0.008), respectively. When data were analyzed separately for study site clusters, a post hoc analysis demonstrated that both SPN-804 dosages were significantly superior to placebo in median percent seizure reduction (placebo: ?13.3%; 1200 mg: ?34.5%, P = 0.02; 2400 mg: ?52.7%, P = 0.006) in the North American study site cluster. A concentration–response analysis also supported a clinically meaningful effect for 1200 mg. Adverse event types reflected the drug's established profile. Adverse event frequency was consistent with a pharmacokinetic profile in which SPN-804 produces lower peak plasma concentrations vs immediate-release OXC. Once-daily dosing was not associated with any new safety signals. Conclusions Adjunctive once-daily SPN-804 improved seizure control in patients with inadequately controlled partial-onset seizures. Adverse event occurrence and discontinuations due to adverse events suggest improved tolerability vs previously published data with immediate-release OXC.

French, JA; Baroldi, P; Brittain, ST; Johnson, JK

2014-01-01

115

Safety Analysis Report for the Triton Test Facility.  

National Technical Information Service (NTIS)

This safety analysis report provides a comprehensive review of the design, construction, and operations of the Triton test facility, located in Room 1006 of Building 332. The safety of the general public, LLNL on-site personnel, and those employees workin...

R. E. Nietert J. L. Morse J. H. Moyer

1984-01-01

116

Systems Analysis of NASA Aviation Safety Program: Final Report  

NASA Technical Reports Server (NTRS)

A three-month study (February to April 2010) of the NASA Aviation Safety (AvSafe) program was conducted. This study comprised three components: (1) a statistical analysis of currently available civilian subsonic aircraft data from the National Transportation Safety Board (NTSB), the Federal Aviation Administration (FAA), and the Aviation Safety Information Analysis and Sharing (ASIAS) system to identify any significant or overlooked aviation safety issues; (2) a high-level qualitative identification of future safety risks, with an assessment of the potential impact of the NASA AvSafe research on the National Airspace System (NAS) based on these risks; and (3) a detailed, top-down analysis of the NASA AvSafe program using an established and peer-reviewed systems analysis methodology. The statistical analysis identified the top aviation "tall poles" based on NTSB accident and FAA incident data from 1997 to 2006. A separate examination of medical helicopter accidents in the United States was also conducted. Multiple external sources were used to develop a compilation of ten "tall poles" in future safety issues/risks. The top-down analysis of the AvSafe was conducted by using a modification of the Gibson methodology. Of the 17 challenging safety issues that were identified, 11 were directly addressed by the AvSafe program research portfolio.

Jones, Sharon M.; Reveley, Mary S.; Withrow, Colleen A.; Evans, Joni K.; Barr, Lawrence; Leone, Karen

2013-01-01

117

Finite element analysis of lumbosacral reconstruction after partial sacrectomy.  

PubMed

Background The biomechanical property of MGT for patients who underwent partial sacrectomy is not well documented, so this study aimed to investigate biomechanical property of lumbosacral reconstruction after partial sacrectomy. Material and Methods Three 3-dimensional finite element models of lumbosacral region were established: 1) an intact model (INT), 2) a defective model in which partial sacrectomy was performed cephalad to S1 foramina (DEF), and 3) a reconstructed model (REC). Results Displacements of anchor point on L3 vertebrae in INT, DEF, and REC model were 6.63 mm, 10.62 mm, 4.29 mm (titanium), and 3.86mm (stainless steel), respectively. Stress distribution of the instrument in REC model showed excessive concentration on the caudal spinal rod, which may cause rod failure between spine and ilia. Maximum von Mise stress of the stainless steel instrument was higher than titanium instruments, and values of stress of the anchor point around the sacroiliac joint in the REC model were 26.4 MPa with titanium instruments and 23.9MPa with stainless steel instruments. Conclusions Lumbosacral reconstruction can significantly increase stiffness of the spinopelvis of patients who underwent partial sacrectomy. However, the rod between L5 and ilia is the weakest region of all instruments. Stainless steel instruments have higher risk of rod failure and are less suitable for lumboiliac arthrodesis than titanium instruments. PMID:24874025

Zheng, Longpo; Li, Ziqiang; Li, Quan; Ji, Fang; Cai, Zhengdong

2014-01-01

118

Finite element analysis of lumbosacral reconstruction after partial sacrectomy  

PubMed Central

Background The biomechanical property of MGT for patients who underwent partial sacrectomy is not well documented, so this study aimed to investigate biomechanical property of lumbosacral reconstruction after partial sacrectomy. Material/Methods Three 3-dimensional finite element models of lumbosacral region were established: 1) an intact model (INT), 2) a defective model in which partial sacrectomy was performed cephalad to S1 foramina (DEF), and 3) a reconstructed model (REC). Results Displacements of anchor point on L3 vertebrae in INT, DEF, and REC model were 6.63 mm, 10.62 mm, 4.29 mm (titanium), and 3.86mm (stainless steel), respectively. Stress distribution of the instrument in REC model showed excessive concentration on the caudal spinal rod, which may cause rod failure between spine and ilia. Maximum von Mise stress of the stainless steel instrument was higher than titanium instruments, and values of stress of the anchor point around the sacroiliac joint in the REC model were 26.4MPa with titanium instruments and 23.9 MPa with stainless steel instruments. Conclusions Lumbosacral reconstruction can significantly increase stiffness of the spinopelvis of patients who underwent partial sacrectomy. However, the rod between L5 and ilia is the weakest region of all instruments. Stainless steel instruments have higher risk of rod failure and are less suitable for lumboiliac arthrodesis than titanium instruments.

Zheng, Longpo; Li, Ziqiang; Li, Quan; Ji, Fang; Cai, Zhengdong

2014-01-01

119

A Stability Analysis for a Semilinear Parabolic Partial Differential Equation.  

National Technical Information Service (NTIS)

The parabolic partial differential equation considered is u sub t = u sub xx + f(u), where minus infinity ch76 x plus infinity and o ch76 t ch76 plus infinity. Under suitable hypotheses pertaining to f, a class of initial data is exhibited: phi(x), minus ...

N. Chafee

1973-01-01

120

Analysis of Human Locomotion based on Partial Measurements  

Microsoft Academic Search

A lot of computer vision applications have to deal with occlusions. In such settings only a subset of the features of interest can be observed, i.e. only incomplete or partial measurements are available. In this article we show how a learned statistical model can be used to make a prediction of the unknown (occluded) features. The probabilistic nature of the

Tobias Jaeggli; Geert Caenen; Rik Fransens; Luc J. Van Gool

2005-01-01

121

Combining Data Sets in a Partial Wave Analysis.  

National Technical Information Service (NTIS)

Partial wave analyses are often done to extract resonance parameters from data. Using analyses of data from the Crystal Barrel Experiment (LEAR) as an example, it will be shown that this can be done with higher reliability and precision if different data ...

U. Thoma

2004-01-01

122

Advancements in partial discharge analysis to diagnose stator winding problems  

Microsoft Academic Search

On-line partial discharge (PD) testing has been used for over 50 years to assess the condition of motor and generator stator winding insulation systems. In the past decade, advanced hardware and software have enabled superior methods of converting the PD data into practical information about the relative condition of the insulation, as well as determining the root causes of any

V. Warren; G. C. Stone; M. Fenger

2000-01-01

123

Risk Assessment and Safety Evaluation Using Probabilistic Fault Tree Analysis  

Microsoft Academic Search

Risk assessment is an essential prelude to the development of accident prevention strategies in any chemical or petrochemical industry. Many techniques and methodologies such as HAZOP, failure mode effect analysis, fault tree analysis, preliminary hazard analysis, quantitative risk assessment and probabilistic safety analysis are available to conduct qualitative, quantitative, and probabilistic risk assessment. However, these methodologies are limited by: extensive

Faisal I. Khan; Tahir Husain

2001-01-01

124

F-Canyon Suspension and Deactivation Safety Analysis Reports  

SciTech Connect

This paper describes Savannah River Site's compliance with the Department of Energy (DOE) direction to suspend current operations, transition to accommodate revised facility missions, and initiate operations to deactivate F-Canyon using a suspension and deactivation safety basis. This paper integrates multiple Workshop theme topics - Lessons Learned from the Safety Analysis Process, Improvements in Documenting Hazard and Accident Analysis, and Closure Issues - Decontamination and Decommissioning. The paper describes the process used to develop safety documentation to support suspension and deactivation activities for F-Canyon. Embodied are descriptive efforts that include development of intermediate and final ''end states'' (e.g., transitional operations), preparation of safety bases documents to support transition, performance of suspension and deactivation activities (e.g. solvent washing, tank/sump flushing, and laboratory waste processing), and downgrade of Safety Class and Safety Significant equipment. The reduction and/or removal of hazards in the facility result in significant risk (frequency times consequence) reduction to the public, site workers, and the environment. Risk reduction then allows the downgrade of safety class and safety significant systems (e.g., ventilation system) and elimination of associated surveillances. The downgrade of safety systems results in significant cost savings.

LOW, JM

2004-04-30

125

Chemical and Physical Properties, Safety and Application of Partially Hydrolized Guar Gum as Dietary Fiber  

PubMed Central

The ideal water-soluble dietary fiber for the fiber-enrichment of foods must be very low in viscosity, tasteless, odorless, and should produce clear solutions in beverages. Partially hydrolyzed guar gum (PHGG) produced from guar gum by enzymatic process has the same chemical structure with intact guar gum but less than one-tenth the original molecular length of guar gum, which make available to be used as film former, foam stabilizer and swelling agent. The viscosity of PHGG is about 10 mPa·s in 5% aqueous solution, whereas 1% solution of guar gum shows range from 2,000 to 3,000 mPa·s. In addition, PHGG is greatly stable against low pH, heat, acid and digestive enzyme. For these reasons, PHGG seems to be one of the most beneficial dietary fiber materials. It also showed that interesting physiological functions still fully exert the nutritional function of a dietary fiber. PHGG has, therefore, been used primarily for a nutritional purpose and became fully integrated food material without altering the rheology, taste, texture and color of final products. PHGG named as Benefiber® in USA has self-affirmation on GRAS status of standard grade PHGG. PHGG named as Sunfiber® is now being used in various beverages, food products and medicinal foods as a safe, natural and functional dietary fiber in all over the world.

Yoon, Seon-Joo; Chu, Djong-Chi; Raj Juneja, Lekh

2008-01-01

126

ESSAA: Embedded System Safety Analysis Assistant (Abstract Only).  

National Technical Information Service (NTIS)

The Embedded System Safety Analysis Assistant (ESSAA) is a knowledge-based tool that can assist in identifying disaster scenarios. Imbedded software issues hazardous control commands to the surrounding hardware. ESSAA is intended to work from outputs to i...

P. Wallace J. Holzer S. Guarro L. Hyatt

1987-01-01

127

Analysis of Event Data Recorder Data for Vehicle Safety Improvement.  

National Technical Information Service (NTIS)

The Volpe Center performed a comprehensive engineering analysis of Event Data Recorder (EDR) data supplied by NHTSA to assess its accuracy and usefulness in crash reconstruction and improvement of vehicle safety systems. The Volpe Center gathered and anal...

M. P. DaSilva

2008-01-01

128

Fast Flux Test Facility final safety analysis report. Amendment 72.  

National Technical Information Service (NTIS)

This document provides the Final Safety Analysis Report (FSAR) Amendment 72 for incorporation into the Fast Flux Test Facility (FFTF) FSAR set. This amendment change incorporates Engineering Change Notices issued subsequent to Amendment 71 and approved fo...

D. A. Gantt

1992-01-01

129

Phipps Plaza South Safety and Security Analysis and Recommendations.  

National Technical Information Service (NTIS)

The safety and security recommendations presented in this report and the analysis upon which the recommendations are based represent an effort to deal systematically and comprehensively with major problems involved in improving security in high - rise hou...

1977-01-01

130

Pattern analysis of partial discharges in SF6 GIS  

Microsoft Academic Search

The measurement of partial discharge(PD) of several faults in gas-insulated system (GIS) is discussed. Phase-resolved PD patterns have been measured using three different PD detection measuring systems: according to the IEC 270 recommendations, a VHF\\/UHF measuring system with narrow band filtering, and the UHF measuring system with wide band filtering. PD patterns are compared using computer-based discrimination tools. The influence

S. Meijer; E. Gulski; J. J. Smit

1998-01-01

131

A stability analysis for a semilinear parabolic partial differential equation  

NASA Technical Reports Server (NTRS)

The parabolic partial differential equation considered is u sub t = u sub xx + f(u), where minus infinity x plus infinity and o t plus infinity. Under suitable hypotheses pertaining to f, a class of initial data is exhibited: phi(x), minus infinity x plus infinity, for which the corresponding solutions u(x,t) appraoch zero as t approaches the limit of plus infinity. This convergence is uniform with respect to x on any compact subinterval of the real axis.

Chafee, N.

1973-01-01

132

Using failure mode and effects analysis to improve patient safety.  

PubMed

Failure mode and effects analysis (FMEA) (ie, prospective risk analysis) involves close examination of high-risk processes to identify needed improvements that will reduce the chance of unintended adverse events. This risk assessment process is used in other industries (ie, manufacturing, aviation) to evaluate system safety. Health care organizations now are using it to evaluate and improve the safety of patient care activities. The FMEA process promotes systematic thinking about the safety of patient care processes (ie, what could go wrong, what needs to be done to prevent failures.) The steps of the FMEA process are described and applied to a high-risk perioperative process. PMID:12885066

Spath, Patrice L

2003-07-01

133

Preliminary Results Obtained in Integrated Safety Analysis of NASA Aviation Safety Program Technologies  

NASA Technical Reports Server (NTRS)

The goal of the NASA Aviation Safety Program (AvSP) is to develop and demonstrate technologies that contribute to a reduction in the aviation fatal accident rate by a factor of 5 by the year 2007 and by a factor of 10 by the year 2022. Integrated safety analysis of day-to-day operations and risks within those operations will provide an understanding of the Aviation Safety Program portfolio. Safety benefits analyses are currently being conducted. Preliminary results for the Synthetic Vision Systems (SVS) and Weather Accident Prevention (WxAP) projects of the AvSP have been completed by the Logistics Management Institute under a contract with the NASA Glenn Research Center. These analyses include both a reliability analysis and a computer simulation model. The integrated safety analysis method comprises two principal components: a reliability model and a simulation model. In the reliability model, the results indicate how different technologies and systems will perform in normal, degraded, and failed modes of operation. In the simulation, an operational scenario is modeled. The primary purpose of the SVS project is to improve safety by providing visual-flightlike situation awareness during instrument conditions. The current analyses are an estimate of the benefits of SVS in avoiding controlled flight into terrain. The scenario modeled has an aircraft flying directly toward a terrain feature. When the flight crew determines that the aircraft is headed toward an obstruction, the aircraft executes a level turn at speed. The simulation is ended when the aircraft completes the turn.

Reveley, Mary S.

2003-01-01

134

Root Cause Analysis: A patient safety tool  

Microsoft Academic Search

All countries reported safety risks, poor coor- dination of care and deficiencies in care of chronic conditions, with no country clearly leading or lagging across the board. 30 per cent of Canadian patients surveyed described medical, medication or lab errors. 46 per cent of these patients indicated that the error caused a serious health problem and 74 per cent reported

Julie Greenall; David U

135

Analysis of the cilostazol safety database  

Microsoft Academic Search

Cilostazol, a type III phosphodiesterase inhibitor, was approved in the United States in 1999 for the reduction of the symptoms of intermittent claudication. This article summarizes the safety data from 8 cilostazol phase 3 controlled clinical trials, involving 2,702 patients: 1,374 receiving cilostazol, 973 assigned to placebo, and 355 taking pentoxifylline. The trials ranged from 12 to 24 weeks in

Craig M Pratt

2001-01-01

136

Using Qualitative Hazard Analysis to Guide Quantitative Safety Analysis  

NASA Technical Reports Server (NTRS)

Quantitative methods can be beneficial in many types of safety investigations. However, there are many difficulties in using quantitative m ethods. Far example, there may be little relevant data available. This paper proposes a framework for using quantitative hazard analysis to prioritize hazard scenarios most suitable for quantitative mziysis. The framework first categorizes hazard scenarios by severity and likelihood. We then propose another metric "modeling difficulty" that desc ribes the complexity in modeling a given hazard scenario quantitatively. The combined metrics of severity, likelihood, and modeling difficu lty help to prioritize hazard scenarios for which quantitative analys is should be applied. We have applied this methodology to proposed concepts of operations for reduced wake separation for airplane operatio ns at closely spaced parallel runways.

Shortle, J. F.; Allocco, M.

2005-01-01

137

Demonstration of a Safety Analysis on a Complex System  

NASA Technical Reports Server (NTRS)

For the past 17 years, Professor Leveson and her graduate students have been developing a theoretical foundation for safety in complex systems and building a methodology upon that foundation. The methodology includes special management structures and procedures, system hazard analyses, software hazard analysis, requirements modeling and analysis for completeness and safety, special software design techniques including the design of human-machine interaction, verification, operational feedback, and change analysis. The Safeware methodology is based on system safety techniques that are extended to deal with software and human error. Automation is used to enhance our ability to cope with complex systems. Identification, classification, and evaluation of hazards is done using modeling and analysis. To be effective, the models and analysis tools must consider the hardware, software, and human components in these systems. They also need to include a variety of analysis techniques and orthogonal approaches: There exists no single safety analysis or evaluation technique that can handle all aspects of complex systems. Applying only one or two may make us feel satisfied, but will produce limited results. We report here on a demonstration, performed as part of a contract with NASA Langley Research Center, of the Safeware methodology on the Center-TRACON Automation System (CTAS) portion of the air traffic control (ATC) system and procedures currently employed at the Dallas/Fort Worth (DFW) TRACON (Terminal Radar Approach CONtrol). CTAS is an automated system to assist controllers in handling arrival traffic in the DFW area. Safety is a system property, not a component property, so our safety analysis considers the entire system and not simply the automated components. Because safety analysis of a complex system is an interdisciplinary effort, our team included system engineers, software engineers, human factors experts, and cognitive psychologists.

Leveson, Nancy; Alfaro, Liliana; Alvarado, Christine; Brown, Molly; Hunt, Earl B.; Jaffe, Matt; Joslyn, Susan; Pinnell, Denise; Reese, Jon; Samarziya, Jeffrey; Sandys, Sean; Shaw, Alan; Zabinsky, Zelda

1997-01-01

138

Westinghouse Hanford Company safety analysis reports and technical safety requirements upgrade program  

SciTech Connect

During Fiscal Year 1992, the US Department of Energy, Richland Operations Office (RL) separately transmitted the following US Department of Energy (DOE) Orders to Westinghouse Hanford Company (WHC) for compliance: DOE 5480.21, ``Unreviewed Safety Questions,`` DOE 5480.22, ``Technical Safety Requirements,`` and DOE 5480.23, ``Nuclear Safety Analysis Reports.`` WHC has proceeded with its impact assessment and implementation process for the Orders. The Orders are closely-related and contain some requirements that are either identical, similar, or logically-related. Consequently, WHC has developed a strategy calling for an integrated implementation of the three Orders. The strategy is comprised of three primary objectives, namely: Obtain DOE approval of a single list of DOE-owned and WHC-managed Nuclear Facilities, Establish and/or upgrade the ``Safety Basis`` for each Nuclear Facility, and Establish a functional Unreviewed Safety Question (USQ) process to govern the management and preservation of the Safety Basis for each Nuclear Facility. WHC has developed policy-revision and facility-specific implementation plans to accomplish near-term tasks associated with the above strategic objectives. This plan, which as originally submitted in August 1993 and approved, provided an interpretation of the new DOE Nuclear Facility definition and an initial list of WHC-managed Nuclear Facilities. For each current existing Nuclear Facility, existing Safety Basis documents are identified and the plan/status is provided for the ISB. Plans for upgrading SARs and developing TSRs will be provided after issuance of the corresponding Rules.

Busche, D.M.

1995-09-01

139

UNIPALS: SOFTWARE FOR PRINCIPAL COMPONENTS ANALYSIS AND PARTIAL LEAST SQUARES REGRESSION  

EPA Science Inventory

Software for the analysis of multivariate chemical data by principal components and partial least squares methods is included on disk. he methods extract latent variables from the chemical data with the UNIversal PArtial Least Squares or UNIPALS algorithm. he software is written ...

140

75 FR 74022 - Safety Analysis Requirements for Defining Adequate Protection for the Public and the Workers  

Federal Register 2010, 2011, 2012, 2013

...Nonreactor Nuclear Facility Safety Analysis Reports.\\1\\ First issued...5480.23, Nuclear Safety Analysis Reports, a set of nuclear...approach the Evaluation Guideline numerical value. The Evaluation Guideline...Facility Documented Safety...

2010-11-30

141

Occupational Analysis: Safety and Health Coordinator  

NSDL National Science Digital Library

The Advanced Technology Environmental and Energy Center (ATEEC) has provided this document which includes an overview of general required competencies for safety and health coordinators in the workplace. General areas of competence such as monitoring health and physical hazards in the work environment, conducting audits and providing information are included, as well as specific tasks in each category. Users must download this resource for viewing, which requires a free log-in. There is no cost to download the item.

2011-03-09

142

Ultrastructural analysis in preclinical safety evaluation.  

PubMed

The first electron microscopic images of biological specimens were made in the 1940s, and the next 30 years comprised an era of descriptive ultrastructure during which transmission electron microscopy (TEM) was integral to an explosion in cellular and molecular biology. However, when questions could no longer be answered by ultrastructural information alone, the use of TEM in biological research declined. Innovative molecular techniques and newer imaging technologies such as confocal fluorescence microscopy filled the gap, providing faster answers with less rigorous training as a prerequisite to data collection. The use of TEM in toxicologic pathology has paralleled the rise and fall of its popularity in other disciplines. However, TEM remains an essential resource that provides direct and unequivocal data to explain and address safety concerns in preclinical toxicity studies. There is still an important place for TEM in preclinical safety evaluation and mechanistic studies, particularly when visualization of subcellular structures provides a link to other endpoints. This review reinforces the value of TEM in preclinical safety testing and model development and encourages best practices for ultrastructural evaluation. PMID:22215513

Fagerland, Jane A; Wall, Henry G; Pandher, Karamjeet; LeRoy, Bruce E; Gagne, Gerard D

2012-01-01

143

Recoverability Analysis for Modified Compressive Sensing with Partially Known Support  

PubMed Central

The recently proposed modified-compressive sensing (modified-CS), which utilizes the partially known support as prior knowledge, significantly improves the performance of recovering sparse signals. However, modified-CS depends heavily on the reliability of the known support. An important problem, which must be studied further, is the recoverability of modified-CS when the known support contains a number of errors. In this letter, we analyze the recoverability of modified-CS in a stochastic framework. A sufficient and necessary condition is established for exact recovery of a sparse signal. Utilizing this condition, the recovery probability that reflects the recoverability of modified-CS can be computed explicitly for a sparse signal with nonzero entries. Simulation experiments have been carried out to validate our theoretical results.

Zhang, Jun; Li, Yuanqing; Gu, Zhenghui; Yu, Zhu Liang

2014-01-01

144

Arthroscopic partial medial meniscectomy: an analysis of unsatisfactory results.  

PubMed

Results of 150 arthroscopic partial medial meniscectomies were analyzed by computer to identify the factors that lead to an unsatisfactory (fair or poor) outcome. The average follow-up for the group was 36 months (range 24-60 months). One-hundred ten men and 40 women were involved, with an average age of 48 years. The overall results were 58% excellent-good, 28% fair, and 14% poor. Most tears involved the posterior horn (76%). Bucket-handle, longitudinal, and flap tears were rated 88% excellent-good, whereas horizontal cleavage and degenerative and complex tears had only 45% excellent-good scores. The results were adversely affected by the severity of the chondromalacia, work-related injury, prior knee surgery, simultaneous lateral meniscectomy, and increased knee laxity. Because degenerative posterior horn tears had such a high percentage of unsatisfactory results, the question remains as to whether all these tears need to be removed. PMID:4091909

Ferkel, R D; Davis, J R; Friedman, M J; Fox, J M; Del Pizzo, W; Snyder, S J; Berasi, C C

1985-01-01

145

Multivariate analysis of remote LIBS spectra using partial least squares, principal component analysis, and related techniques  

SciTech Connect

Quantitative analysis with LIBS traditionally employs calibration curves that are complicated by the chemical matrix effects. These chemical matrix effects influence the LIBS plasma and the ratio of elemental composition to elemental emission line intensity. Consequently, LIBS calibration typically requires a priori knowledge of the unknown, in order for a series of calibration standards similar to the unknown to be employed. In this paper, three new Multivariate Analysis (MV A) techniques are employed to analyze the LIBS spectra of 18 disparate igneous and highly-metamorphosed rock samples. Partial Least Squares (PLS) analysis is used to generate a calibration model from which unknown samples can be analyzed. Principal Components Analysis (PCA) and Soft Independent Modeling of Class Analogy (SIMCA) are employed to generate a model and predict the rock type of the samples. These MV A techniques appear to exploit the matrix effects associated with the chemistries of these 18 samples.

Clegg, Samuel M [Los Alamos National Laboratory; Barefield, James E [Los Alamos National Laboratory; Wiens, Roger C [Los Alamos National Laboratory; Sklute, Elizabeth [MT HOLYOKE COLLEGE; Dyare, Melinda D [MT HOLYOKE COLLEGE

2008-01-01

146

Safety analysis in conceptual design of process control  

NASA Astrophysics Data System (ADS)

The conceptual design of process control systems, and the problem of safety requirements determination are investigated. Safety analysis methods of process design are applied. A two phase method Safe Control Requirements Analysis Method (SCRAM) was applied for analyzing the safety aspects of large processes within reasonable time. The first phase studies potential accidents on the basis of materials handled in the process circumstances. The second phase studies ways in which the process is led to unsafe states and how accidents may subsequently develop. The basic idea is to find the hazardous states of the process, the critical process parameters, and the accident chains. The desired operating conditions and parameters to be controlled are determined. The results show that the method identifies safety critical parameters and control actions and can be used for control system designers' purposes.

Toola, Arja

1992-10-01

147

Safety analysis report for packaging (onsite) steel drum  

SciTech Connect

This Safety Analysis Report for Packaging (SARP) provides the analyses and evaluations necessary to demonstrate that the steel drum packaging system meets the transportation safety requirements of HNF-PRO-154, Responsibilities and Procedures for all Hazardous Material Shipments, for an onsite packaging containing Type B quantities of solid and liquid radioactive materials. The basic component of the steel drum packaging system is the 208 L (55-gal) steel drum.

McCormick, W.A.

1998-09-29

148

Documented Safety Analysis for the Waste Storage Facilities  

Microsoft Academic Search

This documented safety analysis (DSA) for the Waste Storage Facilities was developed in accordance with 10 CFR 830, Subpart B, 'Safety Basis Requirements', and utilizes the methodology outlined in DOE-STD-3009-94, Change Notice 3. The Waste Storage Facilities consist of Area 625 (A625) and the Decontamination and Waste Treatment Facility (DWTF) Storage Area portion of the DWTF complex. These two areas

Laycak

2008-01-01

149

Documented Safety Analysis for the Waste Storage Facilities March 2010  

Microsoft Academic Search

This Documented Safety Analysis (DSA) for the Waste Storage Facilities was developed in accordance with 10 CFR 830, Subpart B, 'Safety Basis Requirements,' and utilizes the methodology outlined in DOE-STD-3009-94, Change Notice 3. The Waste Storage Facilities consist of Area 625 (A625) and the Decontamination and Waste Treatment Facility (DWTF) Storage Area portion of the DWTF complex. These two areas

Laycak

2010-01-01

150

Safety verification in Murphy using fault tree analysis  

Microsoft Academic Search

MURPHY is a language-independent, experimental methodology for building safety-critical, real time software, which will include an integrated tool set. Using Ada as an example, this paper presents a technique for verifying the safety of complex, real-time software using Software Fault Tree Analysis. The templates for Ada are presented along with an example of applying the technique to an Ada program.

Stephen S. Cha; Nancy G. Leveson; Timothy J. Shimeall

1988-01-01

151

Software Safety Analysis of a Flight Guidance System  

NASA Technical Reports Server (NTRS)

This document summarizes the safety analysis performed on a Flight Guidance System (FGS) requirements model. In particular, the safety properties desired of the FGS model are identified and the presence of the safety properties in the model is formally verified. Chapter 1 provides an introduction to the entire project, while Chapter 2 gives a brief overview of the problem domain, the nature of accidents, model based development, and the four-variable model. Chapter 3 outlines the approach. Chapter 4 presents the results of the traditional safety analysis techniques and illustrates how the hazardous conditions associated with the system trace into specific safety properties. Chapter 5 presents the results of the formal methods analysis technique model checking that was used to verify the presence of the safety properties in the requirements model. Finally, Chapter 6 summarizes the main conclusions of the study, first and foremost that model checking is a very effective verification technique to use on discrete models with reasonable state spaces. Additional supporting details are provided in the appendices.

Butler, Ricky W. (Technical Monitor); Tribble, Alan C.; Miller, Steven P.; Lempia, David L.

2004-01-01

152

A new DOE standard for transuranic waste nuclear safety analysis  

SciTech Connect

The DOE Office of Environmental Management (EM) observed through onsite assessments and a review of site-specific lessons learned that transuranic (TRU) waste operations could benefit from standardization of assumptions and approaches used to analyze hazards and select controls. EM collected and compared safety analysis information from DOE sites, including a comparison of the type of TRU waste accidents evaluated and controls selected, as well as specific Airborne Release Fractions (ARFs), Respirable Fractions (RFs), and Damage Ratios (DRs) assumed in accident analyses. This paper recounts the efforts by the DOE and its contractors to bring consistency to the safety analysis process supporting TRU waste operations through an integrated re-engineering effort. EM embarked on a process to re-engineer and standardize TRU safety analysis activities complex-wide. The effort involved DOE headquarters, field offices, and contractors. Five teams were formed to analyze and develop the necessary technical basis for a DOE Technical Standard. The teams looked at general issues including Safety Basis (SB), drum integrity and inspection criteria, hazard controls and analysis, safety analysis review and approval process, and implementation of hazard controls. (authors)

Triay, I.; Chung, D. [U.S. Department of Energy, Washington, D.C. (United States); Woody, J. [Atlas Consulting, Knoxville, TN (United States); Foppe, T. [Carlsbad Technical Assistance Contractor, Carlsbad, NM (United States); Mewhinney, C. [Sandia National Laboratories, Carlsbad, NM (United States); Jennings, S. [Los Alamos National Laboratories, Carlsbad, NM (United States)

2007-07-01

153

Global Sensitivity Analysis of Occupant Egress Safety Model  

Microsoft Academic Search

Identification of the important factors for the occupant egress safety under building fire is important. In order to achieve this goal, a global sensitivity analysis method, Fourier Amplitude Sensitivity Test (FAST), was instead of the local sensitivity analysis to indentify the important factors for the safe evacuation level under building fire. The equation for safe egress level under building fire

KONG De-peng; LU Shou-xiang; LO Sm

2011-01-01

154

10 CFR 63.112 - Requirements for preclosure safety analysis of the geologic repository operations area.  

Code of Federal Regulations, 2010 CFR

...for preclosure safety analysis of the geologic repository...The preclosure safety analysis of the geologic repository...sequences; (c) Data pertaining to the Yucca...analysis; (e) An analysis of the performance of...

2009-01-01

155

10 CFR 63.112 - Requirements for preclosure safety analysis of the geologic repository operations area.  

Code of Federal Regulations, 2010 CFR

...for preclosure safety analysis of the geologic repository...The preclosure safety analysis of the geologic repository...sequences; (c) Data pertaining to the Yucca...analysis; (e) An analysis of the performance of...

2010-01-01

156

Safety analysis of the existing 851 Firing Facility  

SciTech Connect

A safety analysis was performed to determine if normal operations and/or potential accidents at the 851 Firing Facility at Site 300 could present undue hazards to the general public, personnel at Site 300, or have an adverse effect on the environment. The normal operations and credible accidents that might have an effect on these facilities or have off-site consequences were considered. It was determined by this analysis that all but two of the hazards were either low or of the type or magnitude routinely encountered and/or accepted by the public. The exceptions were the linear accelerator and explosives, which were classified as moderate hazards per the requirements given in DOE Order 5481.1A. This safety analysis concluded that the operation at this facility will present no undue risk to the health and safety of LLNL employees or the public.

Odell, B.N.

1986-06-05

157

Safety analysis of the existing 850 Firing Facility  

SciTech Connect

A safety analysis was performed to determine if normal operations and/or potential accidents at the 850 Firing Facility at Site 300 could present undue hazards to the general public, personnel at Site 300, or have an adverse effect on the environment. The normal operations and credible accidents that might have an effect on these facilities or have off-site consequences were considered. It was determined by this analysis that all but one of the hazards were either low or of the type or magnitude routinely encountered and/or accepted by the public. The exception was explosives, which was classified as a moderate hazard per the requirements given in DOE Order 5481.1A. This safety analysis concluded that the operation at this facility will present no undue risk to the health and safety of LLNL employees or the public.

Odell, B.N.

1986-06-05

158

Flood analysis using generalized logistic models in partial duration series  

NASA Astrophysics Data System (ADS)

SummaryAs a generalization of the commonly assumed Poisson distribution (PD) used to estimate the annual number of peaks over threshold in partial duration series (PDS) model, the negative binomial (NB) distribution is proposed in this study. Instead of generalized pareto distribution (GPD) and exponential distribution (ED) models popularly applied to predict the probability of the exceedances of peak over threshold, the performance of the general logistic distribution (GLD) models is analyzed. Two different models for analyzing extreme hydrologic events are compared, based on, PDS and annual maximum series (AMS), respectively. The performance of the two models in terms of uncertainty of T-year event estimator [ q( T)] is evaluated in the cases of estimation with the method of moments (MOMs), maximum likelihood (ML), and probability weighted moments (PWMs). The annual maximum distribution corresponding to a PDS model with Poisson distributed count of peaks above threshold and GLD for flood exceedances was found to be an extreme value type I (EV1) distribution. The comparison between PDS and AMS is made using ratio of variance of the T-year event estimates, which is derived analytically after checking the reliability of the expressions with Monte Carlo simulations. The results reveal that the AMS/NB-GLD and PDS/GLD models using PWM estimation method give least variance of flood estimates with the PDS model giving marginally better results. From the overall results, it was observed that the Poisson distribution performs better, where the difference between mean ( ?) and variance of counts of threshold exceedances is small otherwise the NB distribution is found to be efficient when used in combination with generalized logistic distribution in the PDS model, and this is more prominent for ? < 1.4. Hence, in such cases when the PDS data have a mean less than this, the AMS/NB-GLD and PDS/GLD should be a better model for q( T) estimation as compared to PDS/ED.

Bhunya, P. K.; Singh, R. D.; Berndtsson, R.; Panda, S. N.

2012-02-01

159

Partial pressure analysis of CF/sub 4//O/sub 2/ plasmas  

SciTech Connect

This work will examine a simple down-stream sampling arrangement for effluent analysis in a typical plasma environment. This method offers the advantage of simplicity when compared to the need for extraction optics and energy analyzing stages required for flux-type analysis. In addition, partial pressure analysis provides information on the plasma/surface interactions occurring over the entire surface area of the reactor as opposed to just those occurring at the sampling orifice in flux-type analysis. This fact makes partial-pressure analysis particularly attractive for such tasks as plasma-etch end-point monitoring. In this example, experimental partial-pressure measurements of a CF/sub 4//O/sub 2/ plasma are presented as is the application of the technique to plasma etch end-point detection. 12 refs., 2 figs.

Martz, J.C.; Hess, D.W.; Anderson, W.E.

1989-01-01

160

Analysis and design of partial ground improvement in deep excavations  

Microsoft Academic Search

Excessive wall deflection and ground settlement are common problems for deep excavations in soft clay and frequently damage adjacent buildings. To reduce wall deflection or ground settlement, the in situ soil is usually strengthened by jet grouting or mechanical deep mixing method. Finite element analysis can be conducted to determine improvement ratios, improved depths and improved zones of the soil

Chang-Yu Ou; Fu-Chen Teng; I-Wen Wang

2008-01-01

161

The geography of patient safety: a topical analysis of sterility.  

PubMed

Many studies on patient safety are geared towards prevention of adverse events by eliminating causes of error. In this article, I argue that patient safety research needs to widen its analytical scope and include causes of strength as well. This change of focus enables me to ask other questions, like why don't things go wrong more often? Or, what is the significance of time and space for patient safety? The focal point of this article is on the spatial dimension of patient safety. To gain insight into the 'geography' of patient safety and perform a topical analysis, I will focus on one specific kind of space (sterile space), one specific medical procedure (insertion of an intravenous line) and one specific medical ward (neonatology). Based on ethnographic data from research in the Netherlands, I demonstrate how spatial arrangements produce sterility and how sterility work produces spatial orders at the same time. Detailed analysis shows how a sterile line insertion involves the convergence of spatially distributed resources, relocations of the field of activity, an assemblage of an infrastructure of attention, a specific compositional order of materials, and the scaling down of one's degree of mobility. Sterility, I will argue, turns out to be a product of spatial orderings. Simultaneously, sterility work generates particular spatial orders, like open and restricted areas, by producing buffers and boundaries. However, the spatial order of sterility intersects with the spatial order of other lines of activity. Insight into the normative structure of these co-existing spatial orders turns out to be crucial for patient safety. By analyzing processes of spatial fine-tuning in everyday practice, it becomes possible to identify spatial competences and circumstances that enable staff members to provide safe health care. As such, a topical analysis offers an alternative perspective of patient safety, one that takes into account its spatial dimension. PMID:19857918

Mesman, Jessica

2009-12-01

162

Safety analysis and review system: a Department of Energy safety assurance tool  

SciTech Connect

The concept of the Safety Analysis and Review System is not new. It has been used within the Department and its predecessor agencies, Atomic Energy Commission (AEC) and Energy Research and Development Administration (ERDA), for over 20 years. To minimize the risks from nuclear reactor and power plants, the AEC developed a process to support management authorization of each operation through identification and analysis of potential hazards and the measures taken to control them. As the agency evolved from AEC through ERDA to the Department of Energy, its responsibilities were broadened to cover a diversity of technologies, including those associated with the development of fossil, solar, and geothermal energy. Because the safety analysis process had proved effective in a technology of high potential hazard, the Department investigated the applicability of the process to the other technologies. This paper describes the system and discusses how it is implemented within the Department.

Rosenthal, H.B.

1981-01-01

163

Transperitoneal Approach versus Retroperitoneal Approach: A Meta-Analysis of Laparoscopic Partial Nephrectomy for Renal Cell Carcinoma  

PubMed Central

Objective To compare the efficiency and safety of the transperitoneal approaches with retroperitoneal approaches in laparoscopic partial nephrectomy for renal cell carcinoma and provide evidence-based medicine support for clinical treatment. Methods A systematic computer search of PUBMED, EMBASE, and the Cochrane Library was executed to identify retrospective observational and prospective randomized controlled trials studies that compared the outcomes of the two approaches in laparoscopic partial nephrectomy. Two reviewers independently screened, extracted, and evaluated the included studies and executed statistical analysis by using software STATA 12.0. Outcomes of interest included perioperative and postoperative variables, surgical complications and oncological variables. Results There were 8 studies assessed transperitoneal laparoscopic partial nephrectomy (TLPN) versus retroperitoneal laparoscopic partial nephrectomy (RLPN) were included. RLPN had a shorter operating time (SMD?=?1.001,95%confidence interval[CI] 0.609–1.393,P<0.001), a lower estimated blood loss (SMD?=?0.403,95%CI 0.015–0.791,P?=?0.042) and a shorter length of hospital stay (WMD?=?0.936 DAYS,95%CI 0.609–1.263,P<0.001) than TLPN. There were no significant differences between the transperitoneal and retroperitoneal approaches in other outcomes of interest. Conclusions This meta-analysis indicates that, in appropriately selected patients, especially patients with intraperitoneal procedures history or posteriorly located renal tumors, the RLPN can shorten the operation time, reduce the estimated blood loss and shorten the length of hospital stay. RLPN may be equally safe and be faster compared with the TLPN.

Zhao, Xiaowen; Ni, Shaobin; Zhang, Cheng; Guo, Changgang; Ren, Minghua

2014-01-01

164

Analysis of microbial population dynamics in a partial nitrifying SBR at ambient temperature.  

PubMed

In this study, a lab-scale partial nitrifying sequencing batch reactor (SBR) was developed to investigate partial nitrification at ambient temperature (16-22 °C). Techniques of denaturing gradient gel electrophoresis (DGGE), cloning, and fluorescence in situ hybridization (FISH) were utilized simultaneously to study microbial population dynamics. Partial nitrification was effectively achieved in response to shifts of influent ammonium concentrations. DGGE results showed that higher ammonia concentration referred to lower ammonia-oxidizing bacteria (AOB) diversity in the SBR. Phylogenetic analysis revealed that all the predominant AOB was affiliated with Nitrosomonas genus. FISH analysis illustrated AOB was the predominant nitrifying bacteria of microbial compositions when SBR achieved partial nitrification (PN) at ambient temperature. PMID:23377490

Zeng, Taotao; Li, Dong; Zeng, Huiping; Zhang, Zhao; Liu, Liqian; Zhang, Xiaojing; Zhang, Jie

2013-06-01

165

Analysis of Agc Diversity Combiner for Cpfsk Frequency-Hopping Spread Spectrum Partial-Band Interference  

Microsoft Academic Search

A nonlinear diversity combining scheme known as an adaptive gain control (AGC) receiver is analyzed for a limiter-discriminator-demodulated, slow frequency-hopping CPFSK (FH\\/CPFSK) waveform in partial-band jamming interference. The paper presents an analysis of the system showing that diversity gains are achievable by the AGC receiver for such waveforms transmitted over the worst-case partial-band noise jam- ming channel, provided that noncoherent

Leonard E. Miller; Jhong S. Lee

1992-01-01

166

Analysis of coordination in multi-agent systems through partial difference equations  

Microsoft Academic Search

In this note, we introduce the framework of partial difference equations (PdEs) over graphs for analyzing the behavior of multi-agent systems equipped with decentralized control schemes. Both leaderless and leader-follower models are considered. PdEs mimic partial differential equations (PDEs) on graphs and can be studied by introducing concepts of functional analysis strongly inspired to the corresponding ones arising in PDEs

G. Ferrari-Trecate; A. Buffa; M. Gati

2006-01-01

167

Safety analysis of SISL process module  

SciTech Connect

This report provides an assessment of various postulated accidental occurrences within an experimental process module which is part of a Special Isotope Separation Laboratory (SISL) currently under construction at the Lawrence Livermore National Laboratory (LLNL). The process module will contain large amounts of molten uranium and various water-cooled structures within a vacuum vessel. Special emphasis is therefore given to potential accidental interactions of molten uranium with water leading to explosive and/or rapid steam formation, as well as uranium oxidation and the potential for combustion. Considerations are also given to the potential for vessel melt-through. Evaluations include mechanical and thermal interactions and design implications both in terms of design basis as well as once-in-a-lifetime accident scenarios. These scenarios include both single- and multiple-failure modes leading to various contact modes and locations within the process module for possible thermal interactions. The evaluations show that a vacuum vessel design based upon nominal operating conditions would appear sufficient to meet safety requirements in connection with both design basis as well as once-in-a-lifetime accidents. Controlled venting requirements for removal of steam and hydrogen in order to avoid possible long-term pressurization events are recommended. Depending upon the resulting accident conditions, the vacuum system (i.e., the roughing system) could also serve this purpose. Finally, based upon accident evaluations of this study, immediate shut-off of all coolant water following an incident leak is not recommended, as such action may have adverse effects in terms of cool-down requirements for the melt crucibles etc. These requirements have not been assessed as part of this study.

Not Available

1983-05-01

168

Safety and Tolerability of Pardoprunox, a New Partial Dopamine Agonist, in a Randomized, Controlled Study of Patients with Advanced Parkinson’s Disease  

Microsoft Academic Search

Aims: To investigate the safety and tolerability of pardoprunox (SLV308), a novel partial dopamine agonist, as an adjunct to levodopa in patients with advanced Parkinson’s disease, using two titration schedules. Methods: Patients were randomized to pardoprunox (n = 51) or placebo (n = 11). Pardoprunox was titrated to the highest tolerated dose (range, 0.3–42 mg\\/day) over 7 weeks, using a

R. A. Hauser; J. Bronzova; C. Sampaio; A. E. Lang; O. Rascol; A. Theeuwes; S. V. van de Witte

2009-01-01

169

Partial least squares: a versatile tool for the analysis of high-dimensional genomic data  

Microsoft Academic Search

Partial least squares (PLS) is an efficient statistical regression technique that is highly suited for the analysis of genomic and proteomic data. In this article, we review both the theory underlying PLS as well as a host of bioinformatics applications of PLS. In particular, we provide a systematic comparison of the PLS approaches currently employed, and discuss analysis problems as

Anne-laure Boulesteix; Korbinian Strimmer

2007-01-01

170

Spatial Pattern Analysis of Functional Brain Images Using Partial Least Squares  

Microsoft Academic Search

This paper introduces a new tool for functional neuroimage analysis: partial least squares (PLS). It is unique as a multivariate method in its choice of emphasis for analysis, that being the covariance between brain images and exogenous blocks representing either the experiment design or some behavioral measure. What emerges are spatial patterns of brain activity that represent the optimal association

A. R. McIntosh; F. L. Bookstein; J. V. Haxby; C. L. Grady

1996-01-01

171

Partial least-squares vs. Lanczos bidiagonalization - I: analysis of a projection method for multiple regression  

Microsoft Academic Search

Multiple linear regression is considered and the partial least-squares method (PLS) for computing a projection onto a lower-dimensional subspace is analyzed. The equivalence of PLS to Lanczos bidiagonalization is a basic part of the analysis. Singular value analysis, Krylov subspaces, and shrinkage factors are used to explain why, in many cases, PLS gives a faster reduction of the residual than

Lars Eldén

2004-01-01

172

A novel technique for partial discharge and breakdown investigation based on current pulse waveform analysis  

Microsoft Academic Search

A novel technique for partial discharge (PD) measurement and analysis (PD-CPWA; PD current pulse waveform analysis) is developed and introduced in this paper. PD-CPWA is expected to be utilized to discuss PD mechanisms and physics in electrical insulating materials, focusing on the PD current pulse waveform and its time transition from PD inception to breakdown (BD). In this paper, the

Hitoshi Okubo; Naoki Hayakawa

2005-01-01

173

Degradation Product Analysis for Polymeric Dielectric Materials Exposed to Partial Discharges  

Microsoft Academic Search

Partial discharge phenomena appear to play an important role in insulation failure, and thus the analysis of products resulting from such degradation may lead to an understanding of insulation breakdown mechanisms and more accurate determination of insulation lifetimes. Progress in the area of degradation product analysis is reviewed for solid and liquid insulating materials.

Kevin D. Wolter; Julian F. Johnson; John Tanaka

1978-01-01

174

Safety analysis of irradiated nuclear fuel transportation container  

SciTech Connect

Ignalina NPP comprises two Units with RBMK-1500 reactors. After the Unit 1 of the Ignalina Nuclear Power Plant was shut down in 2004, approximately 1000 fuel assemblies from Unit were available for further reuse in Unit 2. The fuel-transportation container, vehicle, protection shaft and other necessary equipment were designed in order to implement the process for on-site transportation of Unit 1 fuel for reuse in the Unit 2. The Safety Analysis Report (SAR) was developed to demonstrate that the proposed set of equipment performs all functions and assures the required level of safety for both normal operation and accident conditions. The purpose of this paper is to introduce the content and main results of SAR, focusing attention on the container used to transport spent fuel assemblies from Unit I on Unit 2. In the SAR, the structural integrity, thermal, radiological and nuclear safety calculations are performed to assess the acceptance of the proposed set of equipment. The safety analysis demonstrated that the proposed nuclear fuel transportation container and other equipment are in compliance with functional, design and regulatory requirements and assure the required safety level. (authors)

Uspuras, E.; Rimkevicius, S. [Lithuanian Energy Institute, 3 Breslaujos str., LT-3035 Kaunas (Lithuania)

2007-07-01

175

Safety analysis of optically ignited explosive and pyrotechnic devices  

SciTech Connect

The future of optical ordnance depends on the acceptance, validation and verification of the stated safety enhancement claims of optical ordnance over existing electrical explosive devices (EED`s). Sandia has been pursuing the development of optical ordnance, with the primary motivation of this effort being the enhancement of explosive safety by specifically reducing the potential of premature detonation that can occur with low energy electrically ignited explosive devices. By using semiconductor laser diodes for igniting these devices, safety improvements can be made without being detrimental to current system concerns since the inputs required for these devices are similar to electrical systems. Laser Diode Ignition (LDI) of the energetic material provides the opportunity to remove the bridgewire and electrically conductive pins from the charge cavity, creating a Faraday cage and thus isolating the explosive or pyrotechnic materials from stray electrical ignition sources. Recent results from our continued study of safety enhancements are presented. The areas of investigation which are presented include: (1) unintended optical source analysis, specifically lightning insensitivity, (2) electromagnetic radiation (EMR) and electrostatic discharge (ESD) insensitivity analysis, and (3) powder safety.

Merson, J.A.; Salas, F.J.; Holswade, S.

1994-05-01

176

Environmental and Safety Envelope Analysis for Inertial Fusion Applications.  

National Technical Information Service (NTIS)

This paper describes an envelope analysis concept and a generic process flow model which together can be used to identify and isolate plant functions and provide for detailed mass- and energy-balance bookkeeping for environmental and safety studies. Los A...

J. G. Freiwald J. H. Pendergrass T. G. Frank

1980-01-01

177

Real-time risk analysis of safety systems  

Microsoft Academic Search

Methods for plant-specific, real-time, risk assessment are presented using Bayesian analysis with copulas. These are used to develop: (i) a forecasting analyzer that predicts the frequencies of occurrence of abnormal events, (ii) a reliability analyzer that predicts the failure probabilities of safety systems involving equipment and human actions, and (iii) an accident closeness analyzer that predicts the fuzzy memberships to

Anjana Meel; Warren D. Seider

2008-01-01

178

Review Transcriptome Analysis of Organisms with Food Safety Relevance  

Microsoft Academic Search

Transcriptome analysis using microarrays has become a powerful tool to better understand the process of disease and other complex biological processes such as food spoilage and biofilm formation. This review is divided into two basic sections: 1) a short history and description of microarrays and 2) a discussion of studies involving bacterial food safety pathogens that focused on whole genome

Supraja Puttamreddy; Michael D. Carruthers; Melissa L. Madsen; F. Chris Minion

179

Ares I-X Range Safety Flight Envelope Analysis.  

National Technical Information Service (NTIS)

Ares I-X was the first test flight of NASA's Constellation Program's Ares I Crew Launch Vehicle designed to provide manned access to low Earth orbit. As a one-time test flight, the Air Force's 45th Space Wing required a series of Range Safety analysis dat...

A. D. Olds A. S. Craig B. R. Starr

2011-01-01

180

Fast Flux Test Facility final safety analysis report. Amendment 72  

Microsoft Academic Search

This document provides the Final Safety Analysis Report (FSAR) Amendment 72 for incorporation into the Fast Flux Test Facility (FFTF) FSAR set. This amendment change incorporates Engineering Change Notices issued subsequent to Amendment 71 and approved for incorporation before June 24, 1992. These include changes in: Chapter 2, Site Characteristics; Chapter 3, Design Criteria Structures, Equipment, and Systems; Chapter 5B,

Gantt

1992-01-01

181

Safety Analysis for Packaging Steel Banded Wooden Shipping Containers  

SciTech Connect

This safety analysis report for packaging describes the steel banded wooden shipping containers, which are certified as Type AF packagings. The authorized payload for these containers is unirradiated, slightly enriched, uranium ingots, billets, extrusions, and scrap materials. The amount of uranium in the containers will not exceed the LSA-II material requirements as defined in 49 CFR 173.403.

FERRELL, P.C.

2000-12-05

182

NUSAR: N Reactor Updated Safety Analysis Report, Amendment 21.  

National Technical Information Service (NTIS)

The enclosed pages are Amendment 21 of the N Reactor Updated Safety Analysis Report (NUSAR). NUSAR, formerly UNI-M-90, was revised by 18 amendments that were issued by UNC Nuclear Industries, the contractor previously responsible for N Reactor operations....

G. L. Smith

1989-01-01

183

NUSAR: N Reactor Updated Safety Analysis Report-Amendment 19.  

National Technical Information Service (NTIS)

This document comprises Amendment 19 of the N-Reactor Updated Safety Analysis Report (NUSAR). NUSAR, formerly UNI-M-90, was revised by 18 amendments that were issued by UNC Nuclear Industries, the contractor responsible for N-Reactor operations. As of Jun...

M. L. Jack

1989-01-01

184

System safety analysis of an autonomous mobile robot  

Microsoft Academic Search

Analysis of the safety of operating and maintaining the Stored Waste Autonomous Mobile Inspector (SWAMI) II in a hazardous environment at the Fernald Environmental Management Project (FEMP) was completed. The SWAMI II is a version of a commercial robot, the HelpMate{trademark} robot produced by the Transitions Research Corporation, which is being updated to incorporate the systems required for inspecting mixed

Bartos

1994-01-01

185

Level1 Probabilistic Safety Analysis of Prototype Fast Breeder Reactor  

Microsoft Academic Search

This paper summarizes the results from the level-1 Probabilistic Safety Analysis of Prototype Fast Breeder Reactor (PFBR) which is under construction at Kalpakkam. The scope of this study is limited to internal events at full power. The regulatory requirement in India is risk informed and the required target value for overall core damage frequency (CDF) <; le-6 \\/ ry. The

M. Ramakrishnan; Pramod Kumar Sharma; A. J. Arul; V. Bhuvana; P. Mohanakrishnan; S. C. Chetal

2010-01-01

186

Generalized covariance analysis for partially autonomous deep space missions  

NASA Technical Reports Server (NTRS)

A new covariance analysis method is presented that is suitable for the evaluation of multiple impulsive controllers acting on some stochastic process x. The method accommodates batch and sequential estimators with equal ease and accounts for time-delay effects in a natural manner. The formalism is developed in terms of a generalized state vector that is formed from the system state vector x, augmented by various fixed epoch estimates, and a data vector formed from discrete time observations of the system. Recursions are developed for time transition, measurement incorporation, and impulsive control updating of the generalized covariance matrix. Means of limiting the dimensional growth of the generalized state vector via the processes of estimator epoch adjustment and measurement vector deflation are described and the application of numerically stable matrix factorization methods to the generalized covariance recursions is outlined. The method is applied to the Magellan spacecraft to demonstrate the capability of ground-based optimal estimation and control of gyro/star scanner misalignment.

Boone, Jack N.

1991-01-01

187

Safety analysis results for cryostat ingress accidents in ITER  

SciTech Connect

Accidents involving the ingress of air or water into the cryostat of the International Thermonuclear Experimental Reactor (ITER) tokamak design have been analyzed with a modified version of the MELCOR code for the ITER Non-site Specific Safety Report (NSSR-1). The air ingress accident is the result of a postulated breach of the cryostat boundary into an adjoining room. MELCOR results for this accident demonstrate that the condensed air mass and increased heat loads are not a magnet safety concern, but that the partial vacuum in the adjoining room must be accommodated in the building design. The water ingress accident is the result of a postulated magnet arc that results in melting of a Primary Heat Transport System (PHTS) coolant pipe, discharging PHTS water and PHTS water activated corrosion products and HTO into the cryostat. MELCOR results for this accident demonstrate that the condensed water mass and increased heat loads are not a magnet safety concern, that the cryostat pressure remains below design limits, and that the corrosion product and HTO releases are well within the ITER release limits.

Merrill, B.J.; Cadwallader, L.C.; Petti, D.A.

1996-12-31

188

Safety analysis results for cryostat ingress accidents in ITER  

SciTech Connect

Accidents involving the ingress of air, helium, or water into the cryostat of the International Thermonuclear Experimental Reactor (ITER) tokamak design have been analyzed with a modified version of the MELCOR code for the ITER Non-site Specific Safety Report (NSSR-1). The air ingress accident is the result of a postulated breach of the cryostat boundary into an adjoining room. MELCOR results for this accident demonstrate that the condensed air mass and increased heat loads are not a magnet safety concern, but that the partial vacuum in the adjoining room must be accommodated in the building design. The water ingress accident is the result of a postulated magnet arc that results in melting of a Primary Heat Transport System (PHTS) coolant pipe, discharging PHTS water and PHTS water activated corrosion products and HTO into the cryostat. MELCOR results for this accident demonstrate that the condensed water mass and increased heat loads are not a magnet safety concern, that the cryostat pressure remains below design limits, and that the corrosion product and HTO releases are well within the ITER release limits. 6 refs., 2 figs., 1 tab.

Merrill, B.J.; Cadwallader, L.C.; Petti, D.A. [Idaho National Engineering Lab., ID (United States)] [Idaho National Engineering Lab., ID (United States)

1997-06-01

189

Safety Analysis Results for Cryostat Ingress Accidents in ITER  

NASA Astrophysics Data System (ADS)

Accidents involving the ingress of air, helium, or water into the cryostat of the International Thermonuclear Experimental Reactor (ITER) tokamak design have been analyzed with a modified version of the MELCOR code for the ITER Non-site Specific Safety Report (NSSR-1). The air ingress accident is the result of a postulated breach of the cryostat boundary into an adjoining room. MELCOR results for this accident demonstrate that the condensed air mass and increased heat loads are not a magnet safety concern, but that the partial vacuum in the adjoining room must be accommodated in the building design. The water ingress accident is the result of a postulated magnet arc that results in melting of a Primary Heat Transport System (PHTS) coolant pipe, discharging PHTS water and PHTS water activated corrosion products and HTO into the cryostat. MELCOR results for this accident demonstrate that the condensed water mass and increased heat loads are not a magnet safety concern, that the cryostat pressure remains below design limits, and that the corrosion product and HTO releases are well within the ITER release limits.

Merrill, B. J.; Cadwallader, L. C.; Petti, D. A.

1997-06-01

190

Safety Analysis Report for Packaging (Onsite) Multi Canister Overpack Cask  

SciTech Connect

This safety analysis report for packaging (SARP) documents the safety of shipments of irradiated fuel elements in the Multi-canister Overpack (MCO) and MCO Cask and Shippingport Spent Fuel Canister for a highway route controlled quantity, Type B, fissile package. This SARP evaluates the package during transfers of (1) water-filled MCOs from the K Basins to the Cold Vacuum Drying Facility (CVDF) and (2) sealed and cold vacuum dried MCOs from the CVDF in the 100 K Area to the Canister Storage Building in the 200 East Area.

BOEHNKE, W.M.

2001-06-01

191

Nuclear criticality safety tools in the Chernobyl-4 accident analysis  

SciTech Connect

The collaboration with the Italian Safety Authority (DISP), started in July 1986, has the aim of studying, from a neutronic point of view, the possible initiator event and the accident dynamics in unit four of the Chernobly nuclear power plant. This report was produced within the framework of that collaboration. A main condition of the present work was making use of standard calculational methods employed in nuclear criticality safety analysis. This means that the neutron multiplication factor calculation should be made with the modules and the cross-section libraries of the SCALE system or in any case with some KENO IV version and the burnup calculation with the ORIGEN code.

Landeyro, P.A.

1988-01-01

192

Successful Treatment of Painful Irreparable Partial Meniscal Defects With a Polyurethane Scaffold: Two-Year Safety and Clinical Outcomes  

Microsoft Academic Search

Background: A novel, biodegradable, polyurethane scaffold was designed to fulfill an unmet clinical need in the treatment of patients with painful irreparable partial meniscal defects.Hypothesis: The use of an acellular polyurethane scaffold for new tissue generation in irreparable partial meniscal defects provides both pain relief and improved functionality.Study Design: Case series; Level of evidence, 4.Methods: Fifty-two patients with irreparable partial

Peter Verdonk; Philippe Beaufils; Johan Bellemans; Patrick Djian; Eva-Lisa Heinrichs; Wouter Huysse; Heinz Laprell; Rainer Siebold; René Verdonk

2012-01-01

193

Worker Safety and Health and Nuclear Safety Quarterly Performance Analysis (January - March 2008)  

SciTech Connect

The DOE Office of Enforcement expects LLNL to 'implement comprehensive management and independent assessments that are effective in identifying deficiencies and broader problems in safety and security programs, as well as opportunities for continuous improvement within the organization' and to 'regularly perform assessments to evaluate implementation of the contractor's processes for screening and internal reporting.' LLNL has a self-assessment program, described in ES&H Manual Document 4.1, that includes line, management and independent assessments. LLNL also has in place a process to identify and report deficiencies of nuclear, worker safety and health and security requirements. In addition, the DOE Office of Enforcement expects LLNL to evaluate 'issues management databases to identify adverse trends, dominant problem areas, and potential repetitive events or conditions' (page 14, DOE Enforcement Process Overview, December 2007). LLNL requires that all worker safety and health and nuclear safety noncompliances be tracked as 'deficiencies' in the LLNL Issues Tracking System (ITS). Data from the ITS are analyzed for worker safety and health (WSH) and nuclear safety noncompliances that may meet the threshold for reporting to the DOE Noncompliance Tracking System (NTS). This report meets the expectations defined by the DOE Office of Enforcement to review the assessments conducted by LLNL, analyze the issues and noncompliances found in these assessments, and evaluate the data in the ITS database to identify adverse trends, dominant problem areas, and potential repetitive events or conditions. The report attempts to answer three questions: (1) Is LLNL evaluating its programs and state of compliance? (2) What is LLNL finding? (3) Is LLNL appropriately managing what it finds? The analysis in this report focuses on data from the first quarter of 2008 (January through March). This quarter is analyzed within the context of information identified in previous quarters to include April 2007 through March 2008. The results from analyzing the deficiencies are presented in accordance with the two primary NTS reporting thresholds for WSH and nuclear safety noncompliances: (1) those related to certain events or conditions and (2) those that are management issues. In addition, WSH noncompliances were also analyzed to determine if any fell under the 'other significant condition' threshold. This report also identifies noncompliance topical areas that may have issues that do not meet the NTS reporting threshold but should remain under observation. These are placed on the 'watch list' for continued analysis.

Kerr, C E

2009-10-07

194

Safety analysis of the advanced thermionic initiative reactor  

NASA Astrophysics Data System (ADS)

Previously, detailed analysis was conducted to assess the technology developed for the Advanced Thermionic Initiative reactor. This analysis included the development of an overall system design code capability and the improvement of analytical models necessary for the assessment of the use of single cell thermionic fuel elements in a low power space nuclear reactor. The present analysis extends this effort to assess the nuclear criticality safety of the ATI reactor for various different scenarios. The analysis discusses the efficacy of different methods of reactor control such as control rods, and control drums.

Lee, Hsing H.; Klein, Andrew C.

1995-01-01

195

Computational Methods for Sensitivity and Uncertainty Analysis in Criticality Safety  

SciTech Connect

Interest in the sensitivity methods that were developed and widely used in the 1970s (the FORSS methodology at ORNL among others) has increased recently as a result of potential use in the area of criticality safety data validation procedures to define computational bias, uncertainties and area(s) of applicability. Functional forms of the resulting sensitivity coefficients can be used as formal parameters in the determination of applicability of benchmark experiments to their corresponding industrial application areas. In order for these techniques to be generally useful to the criticality safety practitioner, the procedures governing their use had to be updated and simplified. This paper will describe the resulting sensitivity analysis tools that have been generated for potential use by the criticality safety community.

Broadhead, B.L.; Childs, R.L.; Rearden, B.T.

1999-09-20

196

Evolution of Safety Analysis to Support New Exploration Missions  

NASA Technical Reports Server (NTRS)

NASA is currently developing the Ares I launch vehicle as a key component of the Constellation program which will provide safe and reliable transportation to the International Space Station, back to the moon, and later to Mars. The risks and costs of the Ares I must be significantly lowered, as compared to other manned launch vehicles, to enable the continuation of space exploration. It is essential that safety be significantly improved, and cost-effectively incorporated into the design process. This paper justifies early and effective safety analysis of complex space systems. Interactions and dependences between design, logistics, modeling, reliability, and safety engineers will be discussed to illustrate methods to lower cost, reduce design cycles and lessen the likelihood of catastrophic events.

Thrasher, Chard W.

2008-01-01

197

SCALE 6: Comprehensive Nuclear Safety Analysis Code System  

SciTech Connect

Version 6 of the Standardized Computer Analyses for Licensing Evaluation (SCALE) computer software system developed at Oak Ridge National Laboratory, released in February 2009, contains significant new capabilities and data for nuclear safety analysis and marks an important update for this software package, which is used worldwide. This paper highlights the capabilities of the SCALE system, including continuous-energy flux calculations for processing multigroup problem-dependent cross sections, ENDF/B-VII continuous-energy and multigroup nuclear cross-section data, continuous-energy Monte Carlo criticality safety calculations, Monte Carlo radiation shielding analyses with automated three-dimensional variance reduction techniques, one- and three-dimensional sensitivity and uncertainty analyses for criticality safety evaluations, two- and three-dimensional lattice physics depletion analyses, fast and accurate source terms and decay heat calculations, automated burnup credit analyses with loading curve search, and integrated three-dimensional criticality accident alarm system analyses using coupled Monte Carlo criticality and shielding calculations.

Bowman, Stephen M [ORNL

2011-01-01

198

Analysis of dam safety management system in China  

Microsoft Academic Search

Due to an increasing amount of dam damage or break in resent years, great importance is attached to dam safety management in many countries. This paper analyzes the status of Chinese dam safety management according to the integral safety concept for dam including structural safety, dam safety monitoring, operational safety and emergency planning. Comparing with the safety management of large

Cheng Cuiyun; Qian Xin; Zhang Yuchao; Sheng Jinbao

2010-01-01

199

Ares I-X Range Safety Flight Envelope Analysis  

NASA Technical Reports Server (NTRS)

Ares I-X was the first test flight of NASA's Constellation Program's Ares I Crew Launch Vehicle designed to provide manned access to low Earth orbit. As a one-time test flight, the Air Force's 45th Space Wing required a series of Range Safety analysis data products to be developed for the specified launch date and mission trajectory prior to granting flight approval on the Eastern Range. The range safety data package is required to ensure that the public, launch area, and launch complex personnel and resources are provided with an acceptable level of safety and that all aspects of prelaunch and launch operations adhere to applicable public laws. The analysis data products, defined in the Air Force Space Command Manual 91-710, Volume 2, consisted of a nominal trajectory, three sigma trajectory envelopes, stage impact footprints, acoustic intensity contours, trajectory turn angles resulting from potential vehicle malfunctions (including flight software failures), characterization of potential debris, and debris impact footprints. These data products were developed under the auspices of the Constellation's Program Launch Constellation Range Safety Panel and its Range Safety Trajectory Working Group with the intent of beginning the framework for the operational vehicle data products and providing programmatic review and oversight. A multi-center NASA team in conjunction with the 45th Space Wing, collaborated within the Trajectory Working Group forum to define the data product development processes, performed the analyses necessary to generate the data products, and performed independent verification and validation of the data products. This paper outlines the Range Safety data requirements and provides an overview of the processes established to develop both the data products and the individual analyses used to develop the data products, and it summarizes the results of the analyses required for the Ares I-X launch.

Starr, Brett R.; Olds, Aaron D.; Craig, Anthony S.

2011-01-01

200

PAT-1 safety analysis report addendum.  

SciTech Connect

The Plutonium Air Transportable Package, Model PAT-1, is certified under Title 10, Code of Federal Regulations Part 71 by the U.S. Nuclear Regulatory Commission (NRC) per Certificate of Compliance (CoC) USA/0361B(U)F-96 (currently Revision 9). The purpose of this SAR Addendum is to incorporate plutonium (Pu) metal as a new payload for the PAT-1 package. The Pu metal is packed in an inner container (designated the T-Ampoule) that replaces the PC-1 inner container. The documentation and results from analysis contained in this addendum demonstrate that the replacement of the PC-1 and associated packaging material with the T-Ampoule and associated packaging with the addition of the plutonium metal content are not significant with respect to the design, operating characteristics, or safe performance of the containment system and prevention of criticality when the package is subjected to the tests specified in 10 CFR 71.71, 71.73 and 71.74.

Weiner, Ruth F.; Schmale, David T.; Kalan, Robert J.; Akin, Lili A.; Miller, David Russell; Knorovsky, Gerald Albert; Yoshimura, Richard Hiroyuki; Lopez, Carlos; Harding, David Cameron; Jones, Perry L.; Morrow, Charles W.

2010-09-01

201

Concurrent EEG\\/fMRI analysis by multiway Partial Least Squares  

Microsoft Academic Search

Data may now be recorded concurrently from EEG and functional MRI, using the Simultaneous Imaging for Tomographic Electrophysiology (SITE) method. As yet, there is no established means to integrate the analysis of the combined data set. Recognizing that the hemodynamically convolved time-varying EEG spectrum, S, is intrinsically multidimensional in space, frequency, and time motivated us to use multiway Partial Least-Squares

Eduardo Mart??nez-Montes; Pedro A. Valdés-Sosa; Fumikazu Miwakeichi; Robin I. Goldman; Mark S. Cohen; E. Martinez-Montes

2004-01-01

202

Activated sludge monitoring of a wastewater treatment plant using image analysis and partial least squares regression  

Microsoft Academic Search

The biomass present in a wastewater treatment plant was surveyed and their morphological properties related with operating parameters such as the total suspended solids (TSS) and sludge volume index (SVI). For that purpose image analysis was used to provide the morphological data subsequently treated by partial least squares regression (PLS) multivariable statistical technique. The results denoted the existence of a

A. L. Amaral; E. C. Ferreira

2005-01-01

203

Developing parsimonious retailer equity indexes using partial least squares analysis: a method and applications  

Microsoft Academic Search

The information that a retailer’s name communicates to consumers can be a source of competitive advantage for many retailers. Indeed, retailers develop a kind of brand equity, which we refer to as “retailer equity.” To aid both practitioners and researchers, we outline a method, using partial least squares (PLS) analysis for developing parsimonious measures for retailer equity. In addition, we

Dennis B Arnett; Debra A Laverie; Amanda Meiers

2003-01-01

204

Partial least squares (PLS) regression for the analysis of instrument measurements and sensory meat quality data  

Microsoft Academic Search

The partial least squares (PLS) regression technique was used to examine meat quality data derived from instruments (including Warner–Bratzler shear force and Instron Compression) and sensory panels. The data related to beef longissimus dorsi muscles collected during trials to study the effect of hot boning on meat quality. The univariate analysis of tenderness showed that over 60% of the variation

P. J. Toscas; F. D. Shaw; S. L. Beilken

1999-01-01

205

Layerwise partial mixed finite element analysis of magneto-electro-elastic plates  

Microsoft Academic Search

In this paper a partial mixed layerwise finite element model for adaptive plate structures is presented. Static analysis of magneto-electro-elastic laminated plate structures is considered. The mixed finite element formulation is obtained by considering a Reissner mixed variational principle. The mixed functional is formulated using transverse stresses, displacement components and electric and magnetic potentials as primary variables. The other fields

R. Garcia Lage; C. M. Mota Soares; C. A. Mota Soares; J. N. Reddy

2004-01-01

206

Partial attitude and rate gyro bias estimation: observability analysis, filter design, and performance evaluation  

Microsoft Academic Search

This article presents the analysis, design, and performance evaluation of a novel filter for partial attitude and rate gyro bias estimation. In addition to a single body-fixed vector observation of a constant reference vector in inertial coordinates, biased angular velocity measurements are available for filtering purposes, which occurs directly in the space of the vector observations. Appropriate observability conditions are

Pedro Batista; Carlos Silvestre; Paulo Oliveira

2011-01-01

207

Analysis and suppression of interference for on-line monitoring of partial discharge of power transformers  

Microsoft Academic Search

The key to on-line partial discharge (PD) monitoring of power transformers is how to suppress interference effectively. This paper reports an interference qualitative and quantitative analysis on site using a Fast Fourier Transform (FFT) technique. Various periodic interferences have been found, which emanated from the carrier communication, thyristor switching, and high frequency protection signals of the power system as well

Changchang Wang; Xianlie Jin; T. C. Cheng; Shibo Zhang; Zuzhu Dong; Zhongdong Wang; Du Lin; Deheng Zhu

1997-01-01

208

Investigating Importance Weighting of Satisfaction Scores from a Formative Model with Partial Least Squares Analysis  

ERIC Educational Resources Information Center

This study introduced a formative model to investigate the utility of importance weighting on satisfaction scores with partial least squares analysis. Based on the bottom-up theory of satisfaction evaluations, the measurement structure for weighted/unweighted domain satisfaction scores was modeled as a formative model, whereas the measurement…

Wu, Chia-Huei; Chen, Lung Hung; Tsai, Ying-Mei

2009-01-01

209

Finite element analysis of cylindrical shells partially buried in elastic foundations  

Microsoft Academic Search

A method for analyzing cylindrical shells partially buried in an elastic foundation based on the finite element method is presented by using the expansion of a Fourier series in the circumferential direction to define the distribution of the foundation. Numerical analysis of convergence of the results is presented for a gravity load. The effect of the foundation on the distribution

Haryadi Gunawan; Takashi Mikami; Shunji Kanie; Motohiro Sato

2005-01-01

210

Discriminant analysis of high-dimensional data: a comparison of principal components analysis and partial least squares data reduction methods  

Microsoft Academic Search

Partial least squares (PLS) methods are presented as valuable alternatives to principal components analysis (PCA) for compressing high-dimensional data before performing linear discriminant analysis (LDA). It is shown that using PLS, considerable improvement in class separation and thus discriminant ability can be obtained. In general, fewer of the compressed dimensions are required to give the same level of prediction successes,

E. K. Kemsley

1996-01-01

211

Methods and criteria for safety analysis (FIN L2535)  

SciTech Connect

In response to the NRC request for a proposal dated October 20, 1992, Westinghouse Savannah River Company (WSRC) submit this proposal to provide contractural assistance for FIN L2535, ``Methods and Criteria for Safety Analysis,`` as specified in the Statement of Work attached to the request for proposal. The Statement of Work involves development of safety analysis guidance for NRC licensees, arranging a workshop on this guidance, and revising NRC Regulatory Guide 3.52. This response to the request for proposal offers for consideration the following advantages of WSRC in performing this work: Experience, Qualification of Personnel and Resource Commitment, Technical and Organizational Approach, Mobilization Plan, Key Personnel and Resumes. In addition, attached are the following items required by the NRC: Schedule II, Savannah River Site - Job Cost Estimate, NRC Form 189, Project and Budget Proposal for NRC Work, page 1, NRC Form 189, Project and Budget Proposal for NRC Work, page 2, Project Description.

Not Available

1992-12-01

212

Reactor safety analysis computer program features that enhance user productivity  

SciTech Connect

This paper describes several design features of the MARY computer program that increase user productivity. The MARY program was used to analyze behavior of the Savannah River Site (SRS) K Reactor during postulated nuclear and thermal-hydraulic transients, such as overpower and underflow events, before K Reactor was placed in cold standby in 1993. These analyses provide the bases for portions of the accident chapter of the K-Reactor Safety Analysis Report.

Burnett, T.W.T. [Westinghouse Electric Corp., Pittsburgh, PA (United States); Cleaver, B.H. [ABB Government Services, Inc. (United States); Fields, C.C.; McKinney, J.S.; Wooten, L.A. [Westinghouse Savannah River Co., Aiken, SC (United States); Finfrock, S.H. [Westinghouse Hanford Co., Richland, WA (United States)

1993-09-01

213

Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach  

Microsoft Academic Search

Partial least squares discriminant analysis (PLS-DA) is a partial least squares regression of a set Y of binary variables describing the categories of a categorical variable on a set X of predictor variables. It is a compromise between the usual discriminant analysis and a discriminant analysis on the significant principal components of the predictor variables. This technique is specially suited

Miguel Pérez-Enciso; Michel Tenenhaus

2003-01-01

214

Lacosamide adjunctive therapy for partial-onset seizures: a meta-analysis  

PubMed Central

Background. The relative efficacy and safety of lacosamide as adjunctive therapy compared to other antiepileptic drugs has not been well established. Objective. To determine if lacosamide provides improved efficacy and safety, reduced length of hospital stay and improved quality of life compared with other anti-epileptic therapies for adults with partial-onset seizures. Data Sources. A systematic review of the medical literature using Medline (1946–Week 4, 2012), EMBASE (1980–Week 3, 2012), Cochrane Central Register of Controlled Trials (Issue 1 of 12, January 2012). Additional studies were identified (through to February 7, 2012) by searching bibliographies, the FDA drug approval files, clinical trial registries and major national and international neurology meeting abstracts. No restrictions on publication status or language were applied. Study Selection. Randomized controlled trials of lacosamide in adults with partial-onset seizures were included. Data Extraction. Study selection, extraction and risk of bias assessment were performed independently by two authors. Authors of studies were contacted for missing data. Data Synthesis. All pooled analyses used the random effects model. Results. Three trials (1311 patients) met inclusion criteria. Lacosamide increased the 50% responder rate compared to placebo (RR 1.68 [95% CI 1.36 to 2.08]; I2 = 0%). Discontinuation due to adverse events was statistically significantly higher in the lacosamide arm (RR3.13 [95% CI 1.94 to 5.06]; I2 = 0%). Individual adverse events (ataxia, dizziness, fatigue, and nausea) were also significantly higher in the lacosamide group. Limitations. All dosage arms from the included studies were pooled to make a single pair-wise comparison to placebo. Selective reporting of outcomes was found in all of the included RCTs. Conclusions. Lacosamide as adjunctive therapy in patients with partial-onset seizures increases the 50% responder rate but with significantly more adverse events compared to the placebo.

Newman, Jennifer J.; Deshpande, Santosh; Jones, Philip M.

2013-01-01

215

Lacosamide adjunctive therapy for partial-onset seizures: a meta-analysis.  

PubMed

Background. The relative efficacy and safety of lacosamide as adjunctive therapy compared to other antiepileptic drugs has not been well established. Objective. To determine if lacosamide provides improved efficacy and safety, reduced length of hospital stay and improved quality of life compared with other anti-epileptic therapies for adults with partial-onset seizures. Data Sources. A systematic review of the medical literature using Medline (1946-Week 4, 2012), EMBASE (1980-Week 3, 2012), Cochrane Central Register of Controlled Trials (Issue 1 of 12, January 2012). Additional studies were identified (through to February 7, 2012) by searching bibliographies, the FDA drug approval files, clinical trial registries and major national and international neurology meeting abstracts. No restrictions on publication status or language were applied. Study Selection. Randomized controlled trials of lacosamide in adults with partial-onset seizures were included. Data Extraction. Study selection, extraction and risk of bias assessment were performed independently by two authors. Authors of studies were contacted for missing data. Data Synthesis. All pooled analyses used the random effects model. Results. Three trials (1311 patients) met inclusion criteria. Lacosamide increased the 50% responder rate compared to placebo (RR 1.68 [95% CI 1.36 to 2.08]; I(2) = 0%). Discontinuation due to adverse events was statistically significantly higher in the lacosamide arm (RR3.13 [95% CI 1.94 to 5.06]; I(2) = 0%). Individual adverse events (ataxia, dizziness, fatigue, and nausea) were also significantly higher in the lacosamide group. Limitations. All dosage arms from the included studies were pooled to make a single pair-wise comparison to placebo. Selective reporting of outcomes was found in all of the included RCTs. Conclusions. Lacosamide as adjunctive therapy in patients with partial-onset seizures increases the 50% responder rate but with significantly more adverse events compared to the placebo. PMID:23940830

Sawh, Sonja C; Newman, Jennifer J; Deshpande, Santosh; Jones, Philip M

2013-01-01

216

Safety analysis of the existing 804 and 845 firing facilities  

SciTech Connect

A safety analysis was performed to determine if normal operations and/or potential accidents at the 804 and 845 Firing Facilities at Site 300 could present undue hazards to the general public, peronnel at Site 300, or have an adverse effect on the environment. The normal operation and credible accident that might have an effect on these facilities or have off-site consequence were considered. It was determined by this analysis that all but one of the hazards were either low or of the type or magnitude routinely encountered and/or accepted by the public. The exception was explosives. Since this hazard has the potential for causing significant on-site and minimum off-site consequences, Bunkers 804 and 845 have been classified as moderate hazard facilties per DOE Order 5481.1A. This safety analysis concluded that the operation at these facilities will present no undue risk to the health and safety of LLNL employees or the public.

Odell, B.N.

1986-06-05

217

A fuzzy logic methodology for fault-tree analysis in critical safety systems  

SciTech Connect

A new approach for fault-tree analysis in critical safety systems employing fuzzy sets for information representation is presented in this paper. The methodology is based on the utilization of the extension principle for mapping crisp measurements to various degrees of membership in the fuzzy set of linguistic Truth. Criticality alarm systems are used in miscellaneous nuclear fuel processing, handling, and storage facilities to reduce the risk associated with fissile material operations. Fault-tree methodologies are graphic illustrations of tile failure logic associated with the development of a particular system failure (top event) from basic subcomponent failures (primary events). The term event denotes a dynamic change of state that occurs to system elements, which may include hardware, software, human, or environmental factors. A fault-tree represents a detailed, deductive, analysis that requires extensive system information. The knowledge incorporated in a fault tree can be articulated in logical rules of the form [open quotes]IF A is true THEN B is true.[close quotes] However, it is well known that this type of syllogism fails to give an answer when the satisfaction of the antecedent clause is only partial. Zadeh suggested a new type of fuzzy conditional inference. This type of syllogism (generalized modus ponens) reads as follows: Premise: A is partially true Implication: IF A is true THEN B is true Conclusion: B is partially-true. In generalized modus ponens, the antecedent is true only to some degree; hence, it is desired to compute the grade to which the consequent is satisfied. Fuzzy sets provide a natural environment for this type of computation because fuzzy variables (e.g., B) can take fuzzy values (e.g., partially-true).

Erbay, A.; Ikonomopoulos, A. (Univ. of Tennessee, Knoxville (United States))

1993-01-01

218

Comment on ``Pion-nucleon partial-wave analysis to 2 GeV''  

NASA Astrophysics Data System (ADS)

At incident pion energies below 150 MeV, values for the pion charge exchange cross section, derived from the pion-nucleon partial-wave analysis by Arndt et al., are slightly in error because a factor of pc.m.X/pc.m. has been neglected, pc.m.X and pc.m. are the momenta of the scattered neutral and charged pions in the center-of-mass frame, respectively. In addition, an oversight in the center-of-mass to laboratory kinematic transformations has been discoverd in the Scattering Analysis Interactive Dial-in (said) system, a system through which the aforementioned pion-nucleon partial-wave analysis may be accessed. This oversight, in which the mass differences between charged and neutral pions and between protons and nuetrons have been neglected, introduces systematic energy and angular dependent errors to the laboratory differential cross section for pion charge exchange below 150 MeV.

Dowell, M. L.; Rebka, G. A., Jr.

1995-11-01

219

Partial-wave analysis for elastic p{sup 13}C scattering at astrophysical energies  

SciTech Connect

A standard partial-wave analysis was performed on the basis of known measurements of differential cross sections for elastic p{sup 13}C scattering at energies in the range 250-750 keV. This analysis revealed that, in the energy range being considered, it is sufficient to take into account the {sup 3}S{sub 1} wave alone. A potential for the triplet {sup 3}S{sub 1}-wave state of the p{sup 13}C system in the region of the J{sup p}T = 1{sup -1} resonance at 0.55 MeV was constructed on the basis of the phase shifts obtained from the aforementioned partial-wave analysis.

Dubovichenko, S. B., E-mail: dubovichenko@mail.ru [V.G. Fessenkov Astrophysical Institute (Kazakhstan)

2012-03-15

220

Microspectral analysis with laser in microleakage evaluation between infrastructure and veneer materials in fixed partial dentures  

NASA Astrophysics Data System (ADS)

The microleakage at the interface between the metal infrastructure and the veneering part of the fixed partial dentures are a common problem of aesthetic dentistry. It is possible to use the method of laser microspectral analysis for investigations of microleakage at the metal-veneering material interfaces in fixed partial prostheses. The laser microspectral analysis device LMA-10 (Carl Zeiss, Jena) was used equipped with a diffraction spectrometer PGS-2 (Carl Zeiss, Jena). Different fixed partial dentures were used to determine the microleakage between the metal infrastructure and the veneering material. The distribution of chemical elements at interface infiltration was investigated, making a series of craters and establishing the spectra of the vapours emitted from the craters. Data was gathered in various tables of chemical elements showing the quality and the quantity of microleakage. The laser microspectral analysis is a punctual method of analysis, which allows to investigate small quantities of materials of around 0.1 ?g. This method allows to establish the content of atoms and molecules and to perform semi-quantitative and quantitative analysis. By this method it is possible to establish trace elements, i. e. with concentration of ppm (parts per million).

Negrutiu, Meda L.; Sinescu, Cosmin; Draganescu, Gheorghe; Todea, Carmen; Dodenciu, Dorin; Rominu, Roxana

2008-03-01

221

The roles of exposure and speed in road safety analysis.  

PubMed

Speed is a determining factor in road safety analysis. It is generally believed that an increase in speed harms road safety. However, it can also be argued that driving at high speed reduces the length of time exposure and thus the likelihood of a crash. It is therefore critical to clarify the roles that exposure and speed play in road safety analysis. This study evaluates the relationship between speed and crash risk with respect to distance and time exposure, using disaggregated crash and speed data collected from 112 road segments in Hong Kong. A joint probability model based on a full Bayesian method is applied simultaneously to model crash occurrence and crash severity. In addition, we consider the explanatory variables, including road design, weather conditions, and temporal distribution, in the proposed crash prediction model. The results indicate that average speed plays a significant role in crash risk, despite opposing correlations with respect to distance and time exposure; the correlation between speed and crash risk is positive when distance exposure is considered, but negative when time exposure is used. However, in both cases, speed is positively associated with the injury severity. PMID:22664713

Pei, Xin; Wong, S C; Sze, N N

2012-09-01

222

Safety analysis, 200 Area, Savannah River Plant: Separations area operations  

SciTech Connect

The nev HB-Line, located on the fifth and sixth levels of Building 221-H, is designed to replace the aging existing HB-Line production facility. The nev HB-Line consists of three separate facilities: the Scrap Recovery Facility, the Neptunium Oxide Facility, and the Plutonium Oxide Facility. There are three separate safety analyses for the nev HB-Line, one for each of the three facilities. These are issued as supplements to the 200-Area Safety Analysis (DPSTSA-200-10). These supplements are numbered as Sup 2A, Scrap Recovery Facility, Sup 2B, Neptunium Oxide Facility, Sup 2C, Plutonium Oxide Facility. The subject of this safety analysis, the, Plutonium Oxide Facility, will convert nitrate solutions of {sup 238}Pu to plutonium oxide (PuO{sub 2}) powder. All these new facilities incorporate improvements in: (1) engineered barriers to contain contamination, (2) barriers to minimize personnel exposure to airborne contamination, (3) shielding and remote operations to decrease radiation exposure, and (4) equipment and ventilation design to provide flexibility and improved process performance.

Perkins, W.C.; Lee, R.; Allen, P.M.; Gouge, A.P.

1991-07-01

223

Thermohydraulic and Safety Analysis for CARR Under Station Blackout Accident  

SciTech Connect

A thermohydraulic and safety analysis code (TSACC) has been developed using Fortran 90 language to evaluate the transient thermohydraulic behaviors and safety characteristics of the China Advanced Research Reactor(CARR) under Station Blackout Accident(SBA). For the development of TSACC, a series of corresponding mathematical and physical models were considered. Point reactor neutron kinetics model was adopted for solving reactor power. All possible flow and heat transfer conditions under station blackout accident were considered and the optional models were supplied. The usual Finite Difference Method (FDM) was abandoned and a new model was adopted to evaluate the temperature field of core plate type fuel element. A new simple and convenient equation was proposed for the resolution of the transient behaviors of the main pump instead of the complicated four-quadrant model. Gear method and Adams method were adopted alternately for a better solution to the stiff differential equations describing the dynamic behaviors of the CARR. The computational result of TSACC showed the enough safety margin of CARR under SBA. For the purpose of Verification and Validation (V and V), the simulated results of TSACC were compared with those of Relap5/Mdo3. The V and V result indicated a good agreement between the results by the two codes. Because of the adoption of modular programming techniques, this analysis code is expected to be applied to other reactors by easily modifying the corresponding function modules. (authors)

Wenxi Tian; Suizheng Qiu; Guanghui Su; Dounan Jia [Xi'an Jiaotong University, 28 Xianning Road, Xi'an 710049 (China); Xingmin Liu - China Institute of Atomic Energy

2006-07-01

224

Risk assessment and its application to flight safety analysis  

SciTech Connect

Potentially hazardous test activities have historically been a part of Sandia National Labs mission to design, develop, and test new weapons systems. These test activities include high speed air drops for parachute development, sled tests for component and system level studies, multiple stage rocket experiments, and artillery firings of various projectiles. Due to the nature of Sandia's test programs, the risk associated with these activities can never be totally eliminated. However, a consistent set of policies should be available to provide guidance into the level of risk that is acceptable in these areas. This report presents a general set of guidelines for addressing safety issues related to rocket flight operations at Sandia National Laboratories. Even though the majority of this report deals primarily with rocket flight safety, these same principles could be applied to other hazardous test activities. The basic concepts of risk analysis have a wide range of applications into many of Sandia's current operations. 14 refs., 1 tab.

Keese, D.L.; Barton, W.R.

1989-12-01

225

Dominating Clasp of the Financial Sector Revealed by Partial Correlation Analysis of the Stock Market  

PubMed Central

What are the dominant stocks which drive the correlations present among stocks traded in a stock market? Can a correlation analysis provide an answer to this question? In the past, correlation based networks have been proposed as a tool to uncover the underlying backbone of the market. Correlation based networks represent the stocks and their relationships, which are then investigated using different network theory methodologies. Here we introduce a new concept to tackle the above question—the partial correlation network. Partial correlation is a measure of how the correlation between two variables, e.g., stock returns, is affected by a third variable. By using it we define a proxy of stock influence, which is then used to construct partial correlation networks. The empirical part of this study is performed on a specific financial system, namely the set of 300 highly capitalized stocks traded at the New York Stock Exchange, in the time period 2001–2003. By constructing the partial correlation network, unlike the case of standard correlation based networks, we find that stocks belonging to the financial sector and, in particular, to the investment services sub-sector, are the most influential stocks affecting the correlation profile of the system. Using a moving window analysis, we find that the strong influence of the financial stocks is conserved across time for the investigated trading period. Our findings shed a new light on the underlying mechanisms and driving forces controlling the correlation profile observed in a financial market.

Kenett, Dror Y.; Tumminello, Michele; Madi, Asaf; Gur-Gershgoren, Gitit; Mantegna, Rosario N.; Ben-Jacob, Eshel

2010-01-01

226

Safety.  

ERIC Educational Resources Information Center

Discusses safety issues in science, including: allergic reactions to peanuts used in experiments; explosions in lead/acid batteries; and inspection of pressure vessels, such as pressure cookers or model steam engines. (MKR)

Education in Science, 1996

1996-01-01

227

Issues affecting advanced passive light-water reactor safety analysis  

Microsoft Academic Search

Next generation commercial reactor designs emphasize enhanced safety through improved safety system reliability and performance by means of system simplification and reliance on immutable natural forces for system operation. Simulating the performance of these safety systems will be central to analytical safety evaluation of advanced passive reactor designs. Yet the characteristically small driving forces of these safety systems pose challenging

R. J. Beelman; C. D. Fletcher; S. M. Modro

1992-01-01

228

System safety analysis of well-control equipment  

SciTech Connect

In the wake of recent disasters in the oil and gas E and P and petrochemical industries, the importance of system safety analysis is becoming recognized. Reliability assessment techniques, which were developed in the nuclear-power-generation and defense industries, are potentially valuable tools for engineers in the offshore oil and gas business. BOP's and their control systems used on offshore rigs are typically made up of several subsystems. Hydraulic, pneumatic, and electronic modules are interfaced to provide functional control and monitoring of the mechanical BOP's and valves. Two techniques are used for reliability analysis of a blowout preventer (BOP) and a hydraulic control system. Failure modes and effects analysis (FMEA) examines each part and the consequences of its malfunction. Fault tree analysis (FTA) traces undesired events to their causes. Reliability calculations and data sources are addressed.

Fowler, J.H.; Roche, J.R.

1994-09-01

229

Reactor Accident Analysis Methodology for the Advanced Test Reactor Critical Facility Documented Safety Analysis Upgrade  

SciTech Connect

The regulatory requirement to develop an upgraded safety basis for a DOE Nuclear Facility was realized in January 2001 by issuance of a revision to Title 10 of the Code of Federal Regulations Section 830 (10 CFR 830). Subpart B of 10 CFR 830, ''Safety Basis Requirements,'' requires a contractor responsible for a DOE Hazard Category 1, 2, or 3 nuclear facility to either submit by April 9, 2001 the existing safety basis which already meets the requirements of Subpart B, or to submit by April 10, 2003 an upgraded facility safety basis that meets the revised requirements. 10 CFR 830 identifies Nuclear Regulatory Commission (NRC) Regulatory Guide 1.70, ''Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants'' as a safe harbor methodology for preparation of a DOE reactor documented safety analysis (DSA). The regulation also allows for use of a graded approach. This report presents the methodology that was developed for preparing the reactor accident analysis portion of the Advanced Test Reactor Critical Facility (ATRC) upgraded DSA. The methodology was approved by DOE for developing the ATRC safety basis as an appropriate application of a graded approach to the requirements of 10 CFR 830.

Sharp, G.L.; McCracken, R.T.

2003-05-13

230

Reactor Accident Analysis Methodology for the Advanced Test Reactor Critical Facility Documented Safety Analysis Upgrade  

SciTech Connect

The regulatory requirement to develop an upgraded safety basis for a DOE nuclear facility was realized in January 2001 by issuance of a revision to Title 10 of the Code of Federal Regulations Section 830 (10 CFR 830).1 Subpart B of 10 CFR 830, “Safety Basis Requirements,” requires a contractor responsible for a DOE Hazard Category 1, 2, or 3 nuclear facility to either submit by April 9, 2001 the existing safety basis which already meets the requirements of Subpart B, or to submit by April 10, 2003 an upgraded facility safety basis that meets the revised requirements.1 10 CFR 830 identifies Nuclear Regulatory Commission (NRC) Regulatory Guide 1.70, “Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants”2 as a safe harbor methodology for preparation of a DOE reactor documented safety analysis (DSA). The regulation also allows for use of a graded approach. This report presents the methodology that was developed for preparing the reactor accident analysis portion of the Advanced Test Reactor Critical Facility (ATRC) upgraded DSA. The methodology was approved by DOE for developing the ATRC safety basis as an appropriate application of a graded approach to the requirements of 10 CFR 830.

Gregg L. Sharp; R. T. McCracken

2003-06-01

231

Measurements of partial discharges by computer and analysis of partial discharge distribution by the Monte Carlo method  

Microsoft Academic Search

The mechanism of partial discharge (PD) occurring in the CIGRE Method II (CM-II) electrode system, which is a representative closed-void model system is discussed in the context of a computer-aided PD measuring system. Measurements of PD are made for the CM-II electrode system. Effects of the pressure and gas inside the void on the PD are examined. Taking into account

M. Hikita; K. Yamada; A. Nakamura; T. Mizutani; A. Oohasi; M. Ieda

1990-01-01

232

Fault diagnosis in chemical processes using Fisher discriminant analysis, discriminant partial least squares, and principal component analysis  

Microsoft Academic Search

Principal component analysis (PCA) is the most commonly used dimensionality reduction technique for detecting and diagnosing faults in chemical processes. Although PCA contains certain optimality properties in terms of fault detection, and has been widely applied for fault diagnosis, it is not best suited for fault diagnosis. Discriminant partial least squares (DPLS) has been shown to improve fault diagnosis for

Leo H. Chiang; Evan L. Russell; Richard D. Braatz

2000-01-01

233

Analysis of safety from a human clinical trial with pterostilbene.  

PubMed

Objectives. The purpose of this trial was to evaluate the safety of long-term pterostilbene administration in humans. Methodology. The trial was a prospective, randomized, double-blind placebo-controlled intervention trial enrolling patients with hypercholesterolemia (defined as a baseline total cholesterol ?200?mg/dL and/or baseline low-density lipoprotein cholesterol ?100?mg/dL). Eighty subjects were divided equally into one of four groups: (1) pterostilbene 125?mg twice daily, (2) pterostilbene 50?mg twice daily, (3) pterostilbene 50?mg + grape extract (GE) 100?mg twice daily, and (4) matching placebo twice daily for 6-8 weeks. Safety markers included biochemical and subjective measures. Linear mixed models were used to estimate primary safety measure treatment effects. Results. The majority of patients completed the trial (91.3%). The average age was 54 years. The majority of patients were females (71%) and Caucasians (70%). There were no adverse drug reactions (ADRs) on hepatic, renal, or glucose markers based on biochemical analysis. There were no statistically significant self-reported or major ADRs. Conclusion. Pterostilbene is generally safe for use in humans up to 250?mg/day. PMID:23431291

Riche, Daniel M; McEwen, Corey L; Riche, Krista D; Sherman, Justin J; Wofford, Marion R; Deschamp, David; Griswold, Michael

2013-01-01

234

Gene Expression Profile Analysis in Epilepsy by Using the Partial Least Squares Method  

PubMed Central

Purpose. Epilepsy is a common chronic neurological disorder. We aim to investigate the underlying mechanism of epilepsy with partial least squares- (PLS-) based gene expression analysis, which is more sensitive than routine variance/regression analysis. Methods. Two microarray data sets were downloaded from the Gene Expression Omnibus (GEO) database. PLS analysis was used to identify differentially expressed genes. Gene ontology and network analysis were also implemented. Results. A total of 752 genes were identified to be differentially expressed, including 575 depressed and 177 overexpressed genes in patients. For GO enrichment analysis, except for processes related to the nervous system, we also identified overrepresentation of dysregulated genes in angiogenesis. Network analysis revealed two hub genes, CUL3 and EP300, which may serve as potential targets in further therapeutic studies. Conclusion. Our results here may provide new understanding for the underlying mechanisms of epilepsy pathogenesis and will offer potential targets for producing new treatments.

Wang, Dong; Song, Xixiao; Wang, Yan; Li, Xia; Jia, Shanshan; Wang, Zhijing

2014-01-01

235

The prediction of soil carbon fractions using mid-infrared-partial least square analysis  

Microsoft Academic Search

Abstract. This paper describes the application of mid-infrared (MIR) spectroscopy,and partial least-squares (PLS) analysis to predict the concentration of organic carbon fractions present in soil. The PLS calibrations were derived from a standard set of soils that had been analysed for total organic carbon (TOC), particulate organic carbon (POC), and charcoal carbon,(char-C) using physical and chemical,means. PLS calibration models,from this

L. J. Janik; J. O. Skjemstad; K. D. Shepherd; L. R. Spouncer

2007-01-01

236

Stability analysis of multigrid acceleration methods for the solution of partial differential equations  

NASA Technical Reports Server (NTRS)

A calculation is made of the stability of various relaxation schemes for the numerical solution of partial differential equations. A multigrid acceleration method is introduced, and its effects on stability are explored. A detailed stability analysis of a simple case is carried out and verified by numerical experiment. It is shown that the use of multigrids can speed convergence by several orders of magnitude without adversely affecting stability.

Fay, John F.

1990-01-01

237

Failure of All-ceramic Fixed Partial Dentures in vitro and in vivo: Analysis and Modeling  

Microsoft Academic Search

Hertzian cone cracks visible at the loading site of 20 all-ceramic fixed partial dentures (FPDs), tested in vitro, led to the hypotheses that failure was due to the propagation of localized contact damage crack systems (Hertzian stress state) and that such damage was an unlikely clinical failure mode. Fractographic analysis of the 20 laboratory-failed and nine clinically-failed all-ceramic FPDs allowed

J. R. Kelly; J. A. Tesk; J. A. Sorensen

1995-01-01

238

An improved partial wave analysis of KN --> KN from 800 to 1200 MeV\\/c  

Microsoft Academic Search

An extensive search for resonant states has been performed through an energy dependent partial wave analysis of KN data in the momentum region 777 - 1226 MeV\\/c. The K-p --> K-p, KOn differential cross sections, polarization angular distributions and total K-p cross sections were included in the fit. In addition to the well established hyperons, evidence is reported for a

B. Conforto; D. M. Harmsen; T. Lasinski; R. Levi-Setti; M. Raymund; E. Burkhardt; H. Filthuth; S. Klein; H. Oberlack; H. Schleich

1971-01-01

239

Homotopy analysis method for solving a class of fractional partial differential equations  

NASA Astrophysics Data System (ADS)

In this paper, the homotopy analysis method is applied to obtain the solution of fractional partial differential equations with spatial and temporal fractional derivatives in Riesz and Caputo senses, respectively. Some properties of Riesz fractional derivative utilized in obtaining the series solution are proved. Numerical examples demonstrate the effect of changing homotopy auxiliary parameter ? on the convergence of the approximate solution. Also, they illustrate the effect of the fractional derivative orders ? and ? on the solution behavior.

Elsaid, A.

2011-09-01

240

75 FR 69648 - Safety Analysis Requirements for Defining Adequate Protection for the Public and the Workers  

Federal Register 2010, 2011, 2012, 2013

...amendment to the Department of Energy's nuclear safety rule, 10 CFR part...for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports...for U.S. Department of Energy Nonreactor Nuclear Facility Documented...

2010-11-15

241

Network analysis reveals patterns behind air safety events  

NASA Astrophysics Data System (ADS)

Complex networks have been extensively used to study the topological and dynamical characteristics of transportation systems, although far less attention has been devoted to the analysis of specific problems arising in everyday operations. In this work, the use of a network representation is proposed for studying the appearance of Loss of Separation events, a kind of safety occurrence in which two aircraft violate the minimal separation while airborne. The topological analysis of networks representing the structure of traffic flows allows identifying situations in which the probability of appearance of such events is increased. Beyond these specific results, this work demonstrates the usefulness of the complex network approach in the analysis of operational patterns and occurrences.

Zanin, Massimiliano

2014-05-01

242

Upgraded safety analysis document including operations policies, operational safety limits and policy changes. Revision 2  

SciTech Connect

The National Synchrotron Light Source Safety Analysis Reports (1), (2), (3), BNL reports {number_sign}51584, {number_sign}52205 and {number_sign}52205 (addendum) describe the basic Environmental Safety and Health issues associated with the department`s operations. They include the operating envelope for the Storage Rings and also the rest of the facility. These documents contain the operational limits as perceived prior or during construction of the facility, much of which still are appropriate for current operations. However, as the machine has matured, the experimental program has grown in size, requiring more supervision in that area. Also, machine studies have either verified or modified knowledge of beam loss modes and/or radiation loss patterns around the facility. This document is written to allow for these changes in procedure or standards resulting from their current mode of operation and shall be used in conjunction with the above reports. These changes have been reviewed by NSLS and BNL ES and H committee and approved by BNL management.

Batchelor, K.

1996-03-01

243

Ares I-X Malfunction Turn Range Safety Analysis  

NASA Technical Reports Server (NTRS)

Ares I-X was the designation given to the flight test version of the Ares I rocket which was developed by NASA (also known as the Crew Launch Vehicle (CLV) component of the Constellation Program). The Ares I-X flight test vehicle achieved a successful flight test on October 28, 2009, from Pad LC-39B at Kennedy Space Center, Florida (KSC). As part of the flight plan approval for the test vehicle, a range safety malfunction turn analysis was performed to support the risk assessment and vehicle destruct criteria development processes. Several vehicle failure scenarios were identified which could have caused the vehicle trajectory to deviate from its normal flight path. The effects of these failures were evaluated with an Ares I-X 6 degrees-of-freedom (6-DOF) digital simulation, using the Program to Optimize Simulated Trajectories Version II (POST2) simulation tool. The Ares I-X simulation analysis provided output files containing vehicle trajectory state information. These were used by other risk assessment and vehicle debris trajectory simulation tools to determine the risk to personnel and facilities in the vicinity of the launch area at KSC, and to develop the vehicle destruct criteria used by the flight test range safety officer in the event of a flight test anomaly of the vehicle. The simulation analysis approach used for this study is described, including descriptions of the failure modes which were considered and the underlying assumptions and ground rules of the study.

Beaty, J. R.

2011-01-01

244

Fast Flux Test Facility final safety analysis report. Amendment 73  

SciTech Connect

This report provides Final Safety Analysis Report (FSAR) Amendment 73 for incorporation into the Fast Flux Test Facility (FFTR) FSAR set. This page change incorporates Engineering Change Notices (ECNs) issued subsequent to Amendment 72 and approved for incorparoration before May 6, 1993. These changes include: Chapter 3, design criteria structures, equipment, and systems; chapter 5B, reactor coolant system; chapter 7, instrumentation and control systems; chapter 9, auxiliary systems; chapter 11, reactor refueling system; chapter 12, radiation protection and waste management; chapter 13, conduct of operations; chapter 17, technical specifications; chapter 20, FFTF criticality specifications; appendix C, local fuel failure events; and appendix Fl, operation at 680{degrees}F inlet temperature.

Gantt, D.A.

1993-08-01

245

Survey of systems safety analysis methods and their application to nuclear waste management systems  

NASA Astrophysics Data System (ADS)

This report reviews system safety analysis methods and examines their application to nuclear waste management systems. The safety analysis methods examined include expert opinion, maximum credible accident approach, design basis accidents approach, hazard indices, preliminary hazards analysis, failure modes and effects analysis, fault trees, event trees, cause consequence diagrams, GO methodology, Markov modeling, and a general category of consequence analysis models. Previous and ongoing studies on the safety of waste management systems are discussed along with their limitations and potential improvements. The major safety methods and waste management safety related studies are surveyed. This survey provides information on what safety methods are available, what waste management safety areas have been analyzed, and what are potential areas for future study.

Pelto, P. J.; Winegardner, W. K.; Gallucci, R. H. V.

1981-11-01

246

Survey of systems safety analysis methods and their application to nuclear waste management systems  

SciTech Connect

This report reviews system safety analysis methods and examines their application to nuclear waste management systems. The safety analysis methods examined include expert opinion, maximum credible accident approach, design basis accidents approach, hazard indices, preliminary hazards analysis, failure modes and effects analysis, fault trees, event trees, cause-consequence diagrams, G0 methodology, Markov modeling, and a general category of consequence analysis models. Previous and ongoing studies on the safety of waste management systems are discussed along with their limitations and potential improvements. The major safety methods and waste management safety related studies are surveyed. This survey provides information on what safety methods are available, what waste management safety areas have been analyzed, and what are potential areas for future study.

Pelto, P.J.; Winegardner, W.K.; Gallucci, R.H.V.

1981-11-01

247

SAFETY ANALYSIS APPROACH TO TANK 241-SY-101 REMEDIATION ACTIVITIES  

SciTech Connect

An Unreviewed Safety Question was declared related to the unexplained waste surface level growth in high-level radioactive waste storage Tank 241-SY-101 at the Hanford Site in Richland, Washington. Because the waste surface level in Tank 241-SY-101 was growing in a manner inconsistent with previous behavior, the following issues of concern were recognized: (1) The continually rising surface level had the potential to reach physical encumbrances or limits within the tank (e.g., instrumentation, cameras, established Authorization Basis limits, and the double containment boundary) and the potential to significantly change the consequences of previously analyzed accidents (e.g., flammable gas deflagrations). (2) The presence of new hazards because of significant quantities of flammable gas retained in the crust (e.g., crust collapse gas-release events). (3) The potential to inhibit information gathering related to the existing hazards in the tank (e.g., unable to determine surface level to assess the potential for large gas releases). In response to this situation, a Contractor Project Team, which included Department of Energy representation, was formed to constructively address the issue. The team was responsible for developing and evaluating remediation options and executing the chosen option for remediating the surface level rise issue for Tank 241-SY-101. From an Authorization Basis perspective, the following important aspects will be discussed in this paper: (1) The integrated nature of the Project Team. The team consisted of all the organizations necessary to ensure that the time available to remediate Tank 241-SY-101 was effectively used. Most notable is the connectivity of the Nuclear Safety & Licensing organization with the Engineering, Design, and Operations organizations. (2) The ability of the safety analysis support to adjust to and address evolving Project Team goals and dynamic tank conditions. (3) Due to the urgency to mitigate this developing issue, supplemental controls to ensure safety during remediation operations and activities were developed and approved at the Contractor level with DOE cognizance through their participation as an integral part of the Project Team. This approach was selected as the most expedient to meet the aggressive project schedule and changing tank conditions. This project has been successful in meeting established goals because of the effectiveness of an integrated project team that included Nuclear Safety & Licensing at the start, the integral involvement of DOE during each phase of the project, and the ability of the Contractor to develop, approve, and implement the supplemental controls necessary to safely perform operations and activities.

RYAN, G.W.

2000-03-22

248

New enhancements to SCALE for criticality safety analysis  

SciTech Connect

As the speed, available memory, and reliability of computer hardware increases and the cost decreases, the complexity and usability of computer software will increase, taking advantage of the new hardware capabilities. Computer programs today must be more flexible and user friendly than those of the past. Within available resources, the SCALE staff at Oak Ridge National Laboratory (ORNL) is committed to upgrading its computer codes to keep pace with the current level of technology. This paper examines recent additions and enhancements to the criticality safety analysis sections of the SCALE code package. These recent additions and enhancements made to SCALE can be divided into nine categories: (1) new analytical computer codes, (2) new cross-section libraries, (3) new criticality search sequences, (4) enhanced graphical capabilities, (5) additional KENO enhancements, (6) enhanced resonance processing capabilities, (7) enhanced material information processing capabilities, (8) portability of the SCALE code package, and (9) other minor enhancements, modifications, and corrections to SCALE. Each of these additions and enhancements to the criticality safety analysis capabilities of the SCALE code system are discussed below.

Hollenbach, D.F.; Bowman, S.M.; Petrie, L.M.; Parks, C.V. [Oak Ridge National Lab., TN (United States). Computational Physics and Engineering Div.

1995-09-01

249

Safety analysis of the GEM Detector Magnet conductor  

SciTech Connect

The safety of the GEM Detector Magnet is analyzed using a computational model to determine current sharing between the cabled conductor and the external aluminum stabilizer. The model includes inductive and transverse conductive effects due to the geometries of the coil and the conductor. A conservative analysis indicates a peak conductor hotspot temperature of {approximately} 50 K at two seconds after the initiation of quench. After this time, additional heating is limited because most of the current in the normal zone region is carried by the aluminum stabilizer and an external protection circuit should have begun to diminish the total current. The analysis shows that conductor safety requires adequate transverse conductivity between the cable and the aluminum stabilizer. The calculated transverse conductance of the GEM conductor, 1 {times} 10{sup 7} mho/m, is at least 100 times greater than the minimum value necessary to limit the hotspot temperature to {approximately} 50 K after two seconds. This report describes the results of calculations based on a realistic assumption of GEM conductor performance during a quench.

Ferri, M.A.; Hassenzahl, W.V.

1993-08-27

250

Analysis of planetary exploration spacesuit systems and evaluation of a modified partial-gravity simulation technique  

NASA Astrophysics Data System (ADS)

Building on prior experience during Apollo, NASA now plans to send humans back to the Moon and then on to Mars as part of its Vision for Space Exploration. An integral component for enabling this plan is the development of advanced spacesuit systems. A planetary exploration spacesuit system consists of an astronaut, a spacesuit, and the associated surface systems designed to enable completion of mission objectives. This thesis addresses all three aspects, beginning with an examination of the effects of locomotion stability in lunar and Mars gravity from a metabolic energy expenditure standpoint. An experiment to determine the effects of stability on running in reduced gravity was performed with a modified vertical offload partial gravity device. Operations scenarios were also developed, along with engineering analysis to understand the forces and moments involved in partial gravity locomotion. Analysis is presented to assess the applicability of terrestrial exploration systems and to adapt them for planetary exploration. Access systems for partial gravity planetary explorations are described that may allow humans in spacesuits to safely access scientifically significant terrain on the Moon and Mars. Contingency scenarios for effective rescue of astronauts from flat and sloped terrain were also analyzed. Conclusions and recommendations are offered regarding the effectiveness of the simulation technique developed. An Earth-based field testing program plan is presented with the intent of including access systems in the lunar surface system architecture requirements early enough to allow synergies in component design.

Chappell, Steven Patrick

251

Documented Safety Analysis for the B695 Segment  

SciTech Connect

This Documented Safety Analysis (DSA) was prepared for the Lawrence Livermore National Laboratory (LLNL) Building 695 (B695) Segment of the Decontamination and Waste Treatment Facility (DWTF). The report provides comprehensive information on design and operations, including safety programs and safety structures, systems and components to address the potential process-related hazards, natural phenomena, and external hazards that can affect the public, facility workers, and the environment. Consideration is given to all modes of operation, including the potential for both equipment failure and human error. The facilities known collectively as the DWTF are used by LLNL's Radioactive and Hazardous Waste Management (RHWM) Division to store and treat regulated wastes generated at LLNL. RHWM generally processes low-level radioactive waste with no, or extremely low, concentrations of transuranics (e.g., much less than 100 nCi/g). Wastes processed often contain only depleted uranium and beta- and gamma-emitting nuclides, e.g., {sup 90}Sr, {sup 137}Cs, or {sup 3}H. The mission of the B695 Segment centers on container storage, lab-packing, repacking, overpacking, bulking, sampling, waste transfer, and waste treatment. The B695 Segment is used for storage of radioactive waste (including transuranic and low-level), hazardous, nonhazardous, mixed, and other waste. Storage of hazardous and mixed waste in B695 Segment facilities is in compliance with the Resource Conservation and Recovery Act (RCRA). LLNL is operated by the Lawrence Livermore National Security, LLC, for the Department of Energy (DOE). The B695 Segment is operated by the RHWM Division of LLNL. Many operations in the B695 Segment are performed under a Resource Conservation and Recovery Act (RCRA) operation plan, similar to commercial treatment operations with best demonstrated available technologies. The buildings of the B695 Segment were designed and built considering such operations, using proven building systems, and keeping them as simple as possible while complying with industry standards and institutional requirements. No operations to be performed in the B695 Segment or building system are considered to be complex. No anticipated future change in the facility mission is expected to impact the extent of safety analysis documented in this DSA.

Laycak, D

2008-09-11

252

Canister storage building (CSB) safety analysis report phase 3: Safety analysis documentation supporting CSB construction  

SciTech Connect

The Canister Storage Building (CSB) will be constructed in the 200 East Area of the U.S. Department of Energy (DOE) Hanford Site. The CSB will be used to stage and store spent nuclear fuel (SNF) removed from the Hanford Site K Basins. The objective of this chapter is to describe the characteristics of the site on which the CSB will be located. This description will support the hazard analysis and accident analyses in Chapter 3.0. The purpose of this report is to provide an evaluation of the CSB design criteria, the design's compliance with the applicable criteria, and the basis for authorization to proceed with construction of the CSB.

Garvin, L.J.

1997-04-28

253

Stage Right operational safety analysis and evaluation of Pantex personnel operations  

Microsoft Academic Search

This report documents a study (Stage Right Operational Safety Analysis) that was performed to evaluate the effects of new Stage Right operations on the safety of Pantex personnel who perform the operations and maintain the equipment. The primary concern of the evaluation was for personnel safety during Stage Right operations, but operations equipment damage and degradation also were taken into

S. L. K. Rountree; H. O. Whitehurst; E. H. Tomlin; L. F. Restrepo; J. White

1995-01-01

254

Safety analysis forseismic motion of control rods accounting for rod misalignment  

SciTech Connect

The purpose of this report is to provide a summary of the results of three safety analyses performed by the SRL Safety Analysis Group (SAG) to assess the safety impact of control rod motion induced by a Design Basis Earthquake (DBE).

Osmin, W.L.; Paik, I.K.

1992-01-01

255

Analysis of the NFPA Fire Safety Evaluation System for Business Occupancies  

Microsoft Academic Search

The NFPA Fire Safety Evaluation System (FSES) provides a multiattribute approach to evaluating fire safety performance. Published in NFPA 101A, which addresses business occupancy as one of the four types of building use, the FSES consists of a process whereby fire safety parameters are assigned values, and a resulting score is calculated. The analysis in this paper uses the parametric

John M. Watts

1997-01-01

256

A meta-analysis on the impacts of partial cutting on forest structure and carbon storage  

NASA Astrophysics Data System (ADS)

Partial cutting, which removes some individual trees from a forest, is one of the major and widespread forest management practices that can significantly alter both forest structure and carbon (C) storage. Using 748 observations from 81 studies published between 1973 and 2011, we synthesized the impacts of partial cutting on three variables associated with forest structure (mean annual growth of diameter at breast height (DBH), stand basal area, and volume) and four variables related to various C stock components (aboveground biomass C (AGBC), understory C, forest floor C, and mineral soil C). Results show that the growth of DBH increased by 111.9% after partial cutting, compared to the uncut control, with a 95% bootstrapped confidence interval ranging from 92.2 to 135.9%, while stand basal area and volume decreased immediately by 34.2% ([-37.4%, -31.2%]) and 28.4% ([-32.0%, -25.1%]), respectively. On average, partial cutting reduced AGBC by 43.4% ([-47.7%, -39.3%]), increased understory C storage by 391.5% ([220.0%, 603.8%]), but did not show significant effects on C stocks on forest floor and in mineral soil. All the effects, if significant (i.e., on DBH growth, stand basal area, volume, and AGBC), intensified linearly with cutting intensity and decreased linearly over time. Overall, cutting intensity had more strong impacts than the length of recovery time on the responses of those variables to partial cutting. Besides the significant influence of cutting intensity and recovery time, other factors such as climate zone and forest type also affected forest responses to partial cutting. For example, a large fraction of the changes in DBH growth remains unexplained, suggesting the factors not included in the analysis may play a major role. The data assembled in this synthesis were not sufficient to determine how long it would take for a complete recovery after cutting because long-term experiments were scarce. Future efforts should be tailored to increase the duration of the experiments and balance geographic locations of field studies.

Zhou, D.; Zhao, S. Q.; Liu, S.; Oeding, J.

2013-06-01

257

Nuclear Safety Analysis for the Mars Exploration Rover 2003 Project  

NASA Astrophysics Data System (ADS)

The National Aeronautics and Space Administration's Mars Exploration Rover (MER) 2003 project is designed to place two mobile laboratories (Rovers) on Mars to remotely characterize a diversity of rocks and soils. Milestones accomplished so far include two successful launches of identical spacecraft (the MER-A and MER-B missions) from Cape Canaveral Air Force Station, Florida on June 10 and July 7, 2003. Each Rover uses eight Light Weight Radioisotope Heater Units (LWRHUs) fueled with plutonium-238 dioxide to provide local heating of Rover components. The LWRHUs are provided by the U.S. Department of Energy. In addition, small quantities of radioactive materials in sealed sources are used in scientific instrumentation on the Rover. Due to the radioactive nature of these materials and the potential for accidents, a formal Launch Approval Process requires the preparation of a Final Safety Analysis Report (FSAR) for submittal to and independent review by an Interagency Nuclear Safety Review Panel. This paper presents a summary of the FSAR in terms of potential accident scenarios, probabilities, source terms, radiological consequences, mission risks, and uncertainties in the reported results.

Firstenberg, Henry; Rutger, Lyle L.; Mukunda, Meera; Bartram, Bart W.

2004-02-01

258

Phase 2 safety analysis report: National Synchrotron Light Source  

SciTech Connect

The Phase II program was established in order to provide additional space for experiments, and also staging and equipment storage areas. It also provides additional office space and new types of advanced instrumentation for users. This document will deal with the new safety issues resulting from this extensive expansion program, and should be used as a supplement to BNL Report No. 51584 ''National Synchrotron Light Source Safety Analysis Report,'' July 1982 (hereafter referred to as the Phase I SAR). The initial NSLS facility is described in the Phase I SAR. It comprises two electron storage rings, an injection system common to both, experimental beam lines and equipment, and office and support areas, all of which are housed in a 74,000 sq. ft. building. The X-ray Ring provides for 28 primary beam ports and the VUV Ring, 16. Each port is capable of division into 2 or 3 separate beam lines. All ports receive their synchrotron light from conventional bending magnet sources, the magnets being part of the storage ring lattice. 4 refs.

Stefan, P. (ed.)

1989-06-01

259

Hazard screening application guide. Safety Analysis Report Update Program  

SciTech Connect

The basic purpose of hazard screening is to group precesses, facilities, and proposed modifications according to the magnitude of their hazards so as to determine the need for and extent of follow on safety analysis. A hazard is defined as a material, energy source, or operation that has the potential to cause injury or illness in human beings. The purpose of this document is to give guidance and provide standard methods for performing hazard screening. Hazard screening is applied to new and existing facilities and processes as well as to proposed modifications to existing facilities and processes. The hazard screening process evaluates an identified hazards in terms of the effects on people, both on-site and off-site. The process uses bounding analyses with no credit given for mitigation of an accident with the exception of certain containers meeting DOT specifications. The process is restricted to human safety issues only. Environmental effects are addressed by the environmental program. Interfaces with environmental organizations will be established in order to share information.

none,

1992-06-01

260

Safety analysis report for the Galileo Mission. Volume 2: Summary  

NASA Astrophysics Data System (ADS)

The General Purpose Heat Source Radioisotope Thermoelectric Generator (GPHS-RTG) will be used as the prime source of electric power for the spacecraft on the Galileo mission. The use of radioactive material in these missions necessitates evaluations of the radiological risks that may be encountered by launch complex personnel and by the Earth's general population resulting from postulated malfunctions or failures occurring in the mission operations. The purpose of the Final Safety Analysis Report (FSAR) is to present the analyses and results of the latest evaluation of the nuclear safety potential of the GPHS-RTG as employed in the Galileo mission. This evaluation is an extension of earlier work that addressed the planned 1986 launch using the Space Shuttle Vehicle with the Centaur as the upper stage. This extended evaluation represents the launch by the Space Shuttle/IUS vehicle. The IUS stage has been selected as the vehicle to be used to boost the Galileo spacecraft into the Earth escape trajectory after the parking orbit is attained.

1988-12-01

261

Calculation of Ground Water Flow in Safety Analysis of Nuclear Waste Disposal.  

National Technical Information Service (NTIS)

Radionuclide migration in ground water is one of the most important objects in the safety analysis when the possibilities of radioactive waste disposal in the Finnish bedrock is studied. A very independent part of the safety analysis is the analysis of gr...

K. Meling

1984-01-01

262

On the Consequences of Behavioral Adaptations in the Cost–Benefit Analysis of Road Safety Measures  

Microsoft Academic Search

AbstractIt is sometimes argued that road safety measures or automobile safety standards fail to save lives because safer highways or safer cars induce more dangerous driving. A similar but less extreme view is that ignoring the behavioral adaptation of drivers would bias the cost–benefit analysis of a traffic safety measure. This article derives cost–benefit rules for automobile safety regulation when

Olivier Gossner; Pierre Picard

2005-01-01

263

Analysis of factors affecting the performance of partial nitrification in a sequencing batch reactor.  

PubMed

The objective of this study was to analyze the factors affecting the performance of partial nitrification in a sequencing batch reactor. During a 140-day long-term operation, influent pH value, dissolved oxygen (DO), and chemical oxygen demand/nitrogen (COD/N) ratio were selected as operating factors to evaluate the maintenance and recovery of nitrite accumulation. Results showed that high DO concentration (2-4 mg/L) could damage nitrite accumulation immediately. However, nitrite accumulation ratio (NAR) could be increased from 1.68 ± 1.51 to 35.46 ± 7.86% when increasing the pH values from 7.5 to 8.3 due to the increased free ammonia concentration. Afterwards, stable partial nitrification and high NAR could be recovered when the reactor operated under low DO concentration (0.5-1.0 mg/L). However, it required a long time to recover the partial nitrification of the reactor when the influent COD/N ratios were altered. Fluorescence in situ hybridization analysis implied that ammonium oxidizing bacteria were completely recovered to the dominant nitrifying bacteria in the system. Meanwhile, sludge volumetric index of the reactor gradually decreased from 115.6 to 56.6 mL/g, while the mean diameter of sludge improved from 74.57 to 428.8 ?m by using the strategy of reducing settling time. The obtained results could provide useful information between the operational conditions and the performance of partial nitrification when treating nitrogen-rich industrial wastewater. PMID:23942879

Wei, Dong; Du, Bin; Xue, Xiaodong; Dai, Peng; Zhang, Jian

2014-02-01

264

Numerical analysis of a SNOM tip based on a partially cladded optical fiber.  

PubMed

A Scanning Nearfield Optical Microscope (SNOM) tip with partial metallic cladding is presented. For its design, a very demanding 2D eigenvalue analysis of an optical waveguide with material and radiation losses is carried out by the Multiple Multipole Program (MMP) and by the Finite Element Method (FEM). These simulations require some special tricks that are outlined. The computed 2D MMP and FEM results are compared and discussed. This 2D analysis is followed by a full 3D FEM analysis of the SNOM tip. The obtained 3D results confirm the corresponding 2D predictions. Important conclusions regarding the guiding capabilities of the chosen structure and the efficiency of the applied numerical methods are presented. PMID:22109194

Smajic, Jasmin; Hafner, Christian

2011-11-01

265

Probabilistic Safety Analysis Procedures Guide. Sections 8 - 12.  

National Technical Information Service (NTIS)

The probabilistic safety assessment studies performed are intended to produce probabilistic predictive models that can be used and extended by the utilities and by NRC to sharpen the focus of inquiries into a range of issues affecting reactor safety. This...

M. McCann J. Reed C. Ruger K. Shiu T. Teichmann

1985-01-01

266

Partial wave analysis of chic0-->pi+piK+K-  

Microsoft Academic Search

A partial wave analysis of chic0-->pi+pi-K+K- in psi(2S)-->gammachic0 decay is presented using a sample of 14×106 psi(2S) events accumulated by the BES II detector. The data are fitted to the sum of relativistic covariant tensor amplitudes for intermediate resonant decay modes. From the fit, significant contributions to chic0 decays from the channels f0(980)f0(980), f0(980)f0(2200), f0(1370)f0(1710), K*(892)0 Kmacr *(892)0, K0*(1430) Kmacr

M. Ablikim; J. Z. Bai; Y. Ban; J. G. Bian; X. Cai; H. F. Chen; H. S. Chen; H. X. Chen; J. C. Chen; Jin Chen; Y. B. Chen; S. P. Chi; Y. P. Chu; X. Z. Cui; Y. S. Dai; Z. Y. Deng; L. Y. Dong; Q. F. Dong; S. X. Du; Z. Z. Du; J. Fang; S. S. Fang; C. D. Fu; C. S. Gao; Y. N. Gao; S. D. Gu; Y. T. Gu; Y. N. Guo; Y. Q. Guo; Z. J. Guo; F. A. Harris; K. L. He; M. He; Y. K. Heng; H. M. Hu; T. Hu; G. S. Huang; X. P. Huang; X. T. Huang; X. B. Ji; X. S. Jiang; J. B. Jiao; D. P. Jin; S. Jin; Yi Jin; Y. F. Lai; G. Li; H. B. Li; H. H. Li; J. Li; R. Y. Li; S. M. Li; W. D. Li; W. G. Li; X. L. Li; X. Q. Li; Y. L. Li; Y. F. Liang; H. B. Liao; C. X. Liu; F. Liu; Fang Liu; H. H. Liu; H. M. Liu; J. Liu; J. P. Liu; R. G. Liu; Z. A. Liu; F. Lu; G. R. Lu; H. J. Lu; J. G. Lu; C. L. Luo; F. C. Ma; H. L. Ma; L. L. Ma; Q. M. Ma; X. B. Ma; Z. P. Mao; X. H. Mo; J. Nie; S. L. Olsen; H. P. Peng; N. D. Qi; H. Qin; J. F. Qiu; Z. Y. Ren; G. Rong; L. Y. Shan; L. Shang; D. L. Shen; X. Y. Shen; H. Y. Sheng; F. Shi; X. Shi; H. S. Sun; J. F. Sun; S. S. Sun; Y. Z. Sun; Z. J. Sun; Z. Q. Tan; X. Tang; Y. R. Tian; G. L. Tong; G. S. Varner; D. Y. Wang; L. Wang; M. Wang; P. Wang; W. F. Wang; Y. F. Wang; Z. Wang; Zheng Wang; C. L. Wei; D. H. Wei; N. Wu; X. M. Xia; X. X. Xie; B. Xin; G. F. Xu; Y. Xu; M. L. Yan; F. Yang; H. X. Yang; J. Yang; Y. X. Yang; M. H. Ye; Y. X. Ye; Z. Y. Yi; G. W. Yu; C. Z. Yuan; J. M. Yuan; Y. Yuan; S. L. Zang; Y. Zeng; Yu Zeng; B. X. Zhang; C. C. Zhang; D. H. Zhang; H. Y. Zhang; J. W. Zhang; Q. J. Zhang; X. M. Zhang; X. Y. Zhang; Yiyun Zhang; Z. P. Zhang; Z. Q. Zhang; D. X. Zhao; J. W. Zhao; M. G. Zhao; P. P. Zhao; W. R. Zhao; Z. G. Zhao; H. Q. Zheng; J. P. Zheng; Z. P. Zheng; L. Zhou; N. F. Zhou; K. J. Zhu; Q. M. Zhu; Y. C. Zhu; Y. S. Zhu; Yingchun Zhu; Z. A. Zhu; B. A. Zhuang; X. A. Zhuang; B. S. Zou

2005-01-01

267

Partial Wave Analysis of the pi+pi+pi– system in photo-production at CLAS  

SciTech Connect

A partial Wave Analysis (PWA) has been performed on the first high statistics sample of 84,000 {pi}{sup +}{pi}{sup +}{pi}{sup -} photo-produced events from the reaction {gamma} p {yields} {pi}{sup +}{pi}{sup +}{pi}{sup -} n with the tagged photon beam in the 4.8-5.4 GeV energy range. The data were collected from the E01-017 (g6c) running of CLAS in Aug.-Sep. 2001 at Jefferson Lab.

Mina Nozar

2006-07-01

268

New Criticality Safety Analysis Capabilities in SCALE 5.1  

SciTech Connect

Version 5.1 of the SCALE computer software system developed at Oak Ridge National Laboratory, released in 2006, contains several significant enhancements for nuclear criticality safety analysis. This paper highlights new capabilities in SCALE 5.1, including improved resonance self-shielding capabilities; ENDF/B-VI.7 cross-section and covariance data libraries; HTML output for KENO V.a; analytical calculations of KENO-VI volumes with GeeWiz/KENO3D; new CENTRMST/PMCST modules for processing ENDF/B-VI data in TSUNAMI; SCALE Generalized Geometry Package in NEWT; KENO Monte Carlo depletion in TRITON; and plotting of cross-section and covariance data in Javapeno.

Bowman, Stephen M [ORNL; DeHart, Mark D [ORNL; Dunn, Michael E [ORNL; Goluoglu, Sedat [ORNL; Horwedel, James E [ORNL; Petrie Jr, Lester M [ORNL; Rearden, Bradley T [ORNL; Williams, Mark L [ORNL

2007-01-01

269

Numerical Analysis for Structural Safety Evaluation of Butterfly Valves  

NASA Astrophysics Data System (ADS)

Butterfly valves are widely used in current industry to control the fluid flow. They are used for both on-off and throttling applications involving large flows at relatively low operating pressure especially in large size pipelines. For the industrial application of butterfly valves, it must be ensured that the valve could be used safety under the fatigue life and the deformations produced by the pressure of the fluid. In this study, we carried out the structure analysis of the body and the valve disc of the butterfly valve and the numerical simulation was performed by using ANSYS v11.0. The reliability of valve is evaluated under the investigation of the deformation, the leak test and the durability of the valve.

Shin, Myung-Seob; Yoon, Joon-Yong; Park, Han-Yung

2010-06-01

270

Safety analysis report for packaging (onsite) doorstop samplecarrier system  

SciTech Connect

The Doorstop Sample Carrier System consists of a Type B certified N-55 overpack, U.S. Department of Transportation (DOT) specification or performance-oriented 208-L (55-gal) drum (DOT 208-L drum), and Doorstop containers. The purpose of the Doorstop Sample Carrier System is to transport samples onsite for characterization. This safety analysis report for packaging (SARP) provides the analyses and evaluation necessary to demonstrate that the Doorstop Sample Carrier System meets the requirements and acceptance criteria for both Hanford Site normal transport conditions and accident condition events for a Type B package. This SARP also establishes operational, acceptance, maintenance, and quality assurance (QA) guidelines to ensure that the method of transport for the Doorstop Sample Carrier System is performed safely in accordance with WHC-CM-2-14, Hazardous Material Packaging and Shipping.

Obrien, J.H.

1997-02-24

271

Analysis on the Safety Risk of Subway Maintenance Operation  

Microsoft Academic Search

As we all known, the subway plays an important role on the city transit. In order to achieve the safety and dependability of the subway operation, the subway maintenance is absolutely necessary. The primary purpose of the study is to analyze the factors that affect the safety risk of the subway maintenance operation and identify safety hazard during the subway

Fu Rong; Li Qiming

2009-01-01

272

Analysis techniques for airborne laser range safety evaluations  

Microsoft Academic Search

Techniques to evaluate safety of airborne laser operations on the range are reported. The objectives of the safety evaluations were to (1) protect civilian and military personnel from the hazards associated with lasers, (2) provide users with the least restrictive constraints in which to perform their mission and still maintain an adequate degree of safety, and (3) develop a data

M. S. Ramsburg; D. L. Jenkins; R. D. Doerflein

1982-01-01

273

Safety analysis of the 700-horsepower combustion test facility  

SciTech Connect

The objective of the program reported herein was to provide a Safety Analysis of the 700 h.p. Combustion Test Facility located in Building 93 at the Pittsburgh Energy Technology Center. Extensive safety related measures have been incorporated into the design, construction, and operation of the Combustion Test Facility. These include: nitrogen addition to the coal storage bin, slurry hopper, roller mill and pulverizer baghouse, use of low oxygen content combustion gas for coal conveying, an oxygen analyzer for the combustion gas, insulation on hot surfaces, proper classification of electrical equipment, process monitoring instrumentation and a planned remote television monitoring system. Analysis of the system considering these factors has resulted in the determination of overall probabilities of occurrence of hazards as shown in Table I. Implementation of the recommendations in this report will reduce these probabilities as indicated. The identified hazards include coal dust ignition by hot ductwork and equipment, loss of inerting within the coal conveying system leading to a coal dust fire, and ignition of hydrocarbon vapors or spilled oil, or slurry. The possibility of self-heating of coal was investigated. Implementation of the recommendations in this report will reduce the ignition probability to no more than 1 x 10/sup -6/ per event. In addition to fire and explosion hazards, there are potential exposures to materials which have been identified as hazardous to personal health, such as carbon monoxide, coal dust, hydrocarbon vapors, and oxygen deficient atmosphere, but past monitoring experience has not revealed any problem areas. The major environmental hazard is an oil spill. The facility has a comprehensive spill control plan.

Berkey, B.D.

1981-05-01

274

14 CFR Appendix A to Part 417 - Flight Safety Analysis Methodologies and Products for a Launch Vehicle Flown With a Flight Safety...  

Code of Federal Regulations, 2011 CFR

...tracking station used to make flight safety control decisions. A launch operator...safety official to aid in making flight control decisions. A time delay analysis...or manual fail over decision control. (iii) Flight termination system and...

2014-01-01

275

Car manufacturers and global road safety: a word frequency analysis of road safety documents  

PubMed Central

Objective The World Bank believes that the car manufacturers can make a valuable contribution to road safety in poor countries and has established the Global Road Safety Partnership (GRSP) for this purpose. However, some commentators are sceptical. The authors examined road safety policy documents to assess the extent of any bias. Design Word frequency analyses of road safety policy documents from the World Health Organization (WHO) and the GRSP. Main outcome measures The relative occurrence of key road safety terms was quantified by calculating a word prevalence ratio with 95% confidence intervals. Terms for which there was a fourfold difference in prevalence between the documents were tabulated. Results Compared to WHO's World report on road traffic injury prevention, the GRSP road safety documents were substantially less likely to use the words speed, speed limits, child restraint, pedestrian, public transport, walking, and cycling, but substantially more likely to use the words school, campaign, driver training, and billboard. Conclusions There are important differences in emphasis in road safety policy documents prepared by WHO and the GRSP. Vigilance is needed to ensure that the road safety interventions that the car industry supports are based on sound evidence of effectiveness.

Roberts, I; Wentz, R; Edwards, P

2006-01-01

276

Efficacy and safety of levetiracetam as adjunctive treatment of refractory partial seizures in a multicentre open-label single-arm trial in Korean patients.  

PubMed

This prospective, open-label study evaluated the efficacy and safety of adjunctive levetiracetam (LEV) in Korean adults with uncontrolled partial epilepsy. Study patients had to have an average of at least 1 and not more than 14 partial seizures per month (averaged over a 3-month historical baseline) despite the use of one or two AEDs. Patients initially received LEV 1000 mg/day (administered bid) and could increase to 2000 mg/day after 2 weeks, and to 3000 mg/day after another 2 weeks, to obtain adequate seizure control. During the 12-week maintenance period, the dose of LEV could be increased or decreased once if seizure control was insufficient or tolerability warranted, respectively. Seizure count and adverse events (AEs) were recorded by patients. Global evaluation scale (GES) and quality of life (QOLIE-31) were also evaluated. A total of 100 patients were enrolled and 92 patients completed the study. The median percent reduction in weekly seizure frequency over the treatment period was 43.2%. The >or=50% and >or=75% responder rates were 45.4% and 36.1%, respectively. Seizure freedom throughout the 16-week treatment period was observed in 17 patients. On investigator's GES, 81 patients were considered improved, with 41 patients showing marked improvement. Most QOLIE-31 scales improved significantly. Treatment-emergent AEs were reported in 59 patients. Three most common AEs were somnolence (36%), dizziness (12%), and headache (8%). Adjunctive LEV therapy was effective and well-tolerated in Korean adults with refractory partial epilepsy. PMID:17369059

Heo, Kyoung; Lee, Byung In; Yi, Sang Do; Huh, Kyoon; Kim, Jae Moon; Lee, Sang Ahm; Shin, Dong Jin; Song, Hong Ki; Lee, Sang Kun; Kim, Jeong Yeon; Lu, Sarah; Dubois, Cécilia; Tonner, Françoise

2007-07-01

277

Analysis of effect of flameholder characteristics on lean, premixed, partially vaporized fuel-air mixtures quality and nitrogen oxides emissions  

NASA Technical Reports Server (NTRS)

An analysis was conducted of the effect of flameholding devices on the precombustion fuel-air characteristics and on oxides of nitrogen (NOx) emissions for combustion of premixed partially vaporized mixtures. The analysis includes the interrelationships of flameholder droplet collection efficiency, reatomization efficiency and blockage, and the initial droplet size distribution and accounts for the contribution of droplet combustion in partially vaporized mixtures to NOx emissions. Application of the analytical procedures is illustrated and parametric predictions of NOx emissions are presented.

Cooper, L. P.

1981-01-01

278

Safety Analysis of FMS/CTAS Interactions During Aircraft Arrivals  

NASA Technical Reports Server (NTRS)

This grant funded research on human-computer interaction design and analysis techniques, using future ATC environments as a testbed. The basic approach was to model the nominal behavior of both the automated and human procedures and then to apply safety analysis techniques to these models. Our previous modeling language, RSML, had been used to specify the system requirements for TCAS II for the FAA. Using the lessons learned from this experience, we designed a new modeling language that (among other things) incorporates features to assist in designing less error-prone human-computer interactions and interfaces and in detecting potential HCI problems, such as mode confusion. The new language, SpecTRM-RL, uses "intent" abstractions, based on Rasmussen's abstraction hierarchy, and includes both informal (English and graphical) specifications and formal, executable models for specifying various aspects of the system. One of the goals for our language was to highlight the system modes and mode changes to assist in identifying the potential for mode confusion. Three published papers resulted from this research. The first builds on the work of Degani on mode confusion to identify aspects of the system design that could lead to potential hazards. We defined and modeled modes differently than Degani and also defined design criteria for SpecTRM-RL models. Our design criteria include the Degani criteria but extend them to include more potential problems. In a second paper, Leveson and Palmer showed how the criteria for indirect mode transitions could be applied to a mode confusion problem found in several ASRS reports for the MD-88. In addition, we defined a visual task modeling language that can be used by system designers to model human-computer interaction. The visual models can be translated into SpecTRM-RL models, and then the SpecTRM-RL suite of analysis tools can be used to perform formal and informal safety analyses on the task model in isolation or integrated with the rest of the modeled system. We had hoped to be able to apply these modeling languages and analysis tools to a TAP air/ground trajectory negotiation scenario, but the development of the tools took more time than we anticipated.

Leveson, Nancy G.

1998-01-01

279

DNA Damage Focus Analysis in Blood Samples of Minipigs Reveals Acute Partial Body Irradiation  

PubMed Central

Radiation accidents frequently involve acute high dose partial body irradiation leading to victims with radiation sickness and cutaneous radiation syndrome that implements radiation-induced cell death. Cells that are not lethally hit seek to repair ionizing radiation (IR) induced damage, albeit at the expense of an increased risk of mutation and tumor formation due to misrepair of IR-induced DNA double strand breaks (DSBs). The response to DNA damage includes phosphorylation of histone H2AX in the vicinity of DSBs, creating foci in the nucleus whose enumeration can serve as a radiation biodosimeter. Here, we investigated ?H2AX and DNA repair foci in peripheral blood lymphocytes of Göttingen minipigs that experienced acute partial body irradiation (PBI) with 49 Gy (±6%) Co-60 ?-rays of the upper lumbar region. Blood samples taken 4, 24 and 168 hours post PBI were subjected to ?-H2AX, 53BP1 and MRE11 focus enumeration. Peripheral blood lymphocytes (PBL) of 49 Gy partial body irradiated minipigs were found to display 1–8 DNA damage foci/cell. These PBL values significantly deceed the high foci numbers observed in keratinocyte nuclei of the directly ?-irradiated minipig skin regions, indicating a limited resident time of PBL in the exposed tissue volume. Nonetheless, PBL samples obtained 4 h post IR in average contained 2.2% of cells displaying a pan-?H2AX signal, suggesting that these received a higher IR dose. Moreover, dispersion analysis indicated partial body irradiation for all 13 minipigs at 4 h post IR. While dose reconstruction using ?H2AX DNA repair foci in lymphocytes after in vivo PBI represents a challenge, the DNA damage focus assay may serve as a rapid, first line indicator of radiation exposure. The occurrence of PBLs with pan-?H2AX staining and of cells with relatively high foci numbers that skew a Poisson distribution may be taken as indicator of acute high dose partial body irradiation, particularly when samples are available early after IR exposure.

Lamkowski, Andreas; Forcheron, Fabien; Agay, Diane; Ahmed, Emad A.; Drouet, Michel; Meineke, Viktor; Scherthan, Harry

2014-01-01

280

DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation.  

PubMed

Radiation accidents frequently involve acute high dose partial body irradiation leading to victims with radiation sickness and cutaneous radiation syndrome that implements radiation-induced cell death. Cells that are not lethally hit seek to repair ionizing radiation (IR) induced damage, albeit at the expense of an increased risk of mutation and tumor formation due to misrepair of IR-induced DNA double strand breaks (DSBs). The response to DNA damage includes phosphorylation of histone H2AX in the vicinity of DSBs, creating foci in the nucleus whose enumeration can serve as a radiation biodosimeter. Here, we investigated ?H2AX and DNA repair foci in peripheral blood lymphocytes of Göttingen minipigs that experienced acute partial body irradiation (PBI) with 49 Gy (± 6%) Co-60 ?-rays of the upper lumbar region. Blood samples taken 4, 24 and 168 hours post PBI were subjected to ?-H2AX, 53BP1 and MRE11 focus enumeration. Peripheral blood lymphocytes (PBL) of 49 Gy partial body irradiated minipigs were found to display 1-8 DNA damage foci/cell. These PBL values significantly deceed the high foci numbers observed in keratinocyte nuclei of the directly ?-irradiated minipig skin regions, indicating a limited resident time of PBL in the exposed tissue volume. Nonetheless, PBL samples obtained 4 h post IR in average contained 2.2% of cells displaying a pan-?H2AX signal, suggesting that these received a higher IR dose. Moreover, dispersion analysis indicated partial body irradiation for all 13 minipigs at 4 h post IR. While dose reconstruction using ?H2AX DNA repair foci in lymphocytes after in vivo PBI represents a challenge, the DNA damage focus assay may serve as a rapid, first line indicator of radiation exposure. The occurrence of PBLs with pan-?H2AX staining and of cells with relatively high foci numbers that skew a Poisson distribution may be taken as indicator of acute high dose partial body irradiation, particularly when samples are available early after IR exposure. PMID:24498326

Lamkowski, Andreas; Forcheron, Fabien; Agay, Diane; Ahmed, Emad A; Drouet, Michel; Meineke, Viktor; Scherthan, Harry

2014-01-01

281

Preparation and application of a partially degradable gel in mass spectrometry-based proteomic analysis.  

PubMed

In-gel digestion is an attractive route in mass spectrometry-based proteomic analysis, which, however, often suffers from a certain amount of sample loss mainly due to insufficient protein digestion and peptide extraction. To address this, herein we establish a partially degradable gel-assisted protein digestion and peptide recovery method by means of a simple replacement of bis-acrylamide (BA) with bis-acrylylcystamine (BAC). Concretely, the protein sample solubilized using high concentrations of sodium dodecyl sulfate (SDS) and urea were directly entrapped and immobilized into BAC-crosslinked gel by vacuum-dried gel absorption followed by fixation treatment. After removal of SDS and urea by repeated washing, the proteins were subjected to in-gel digestion and the gel was reductively treated. The tryptic peptides were recovered from the partial degradation of the gel and analyzed afterwards by capillary liquid chromatography coupled with tandem mass spectrometry (CapLC-MS/MS). Compared with conventional BA-crosslinked gel method, this new method increased the numbers of identified proteins and unique peptides by 20.2% and 20.4%, respectively. The further statistical analysis demonstrated that the method improved the recovery of tryptic peptides particularly larger and/or hydrophobic peptides, thereby significantly facilitating protein identification. Thus, the newly developed method is a promising alternative for BA-crosslinked gel-based shotgun workflows and has potential application in the related fields of protein chemistry and proteomics. PMID:21920827

Zhou, Jian; Hu, Yongbo; Lin, Yong; Liu, Haipeng; Xie, Peng

2011-10-15

282

Evaluating the effect of partial contributing storage on the storage-discharge function from recession analysis  

NASA Astrophysics Data System (ADS)

Hydrograph recession during dry periods has been used to construct water storage-discharge relationships and to quantify storage dynamics and evaporation when streamflow data is available. However, variable hydrologic connectivity among hillslope-riparian-stream zones may affect the lumped storage-discharge relationship, and as a result, affect the estimation of evaporation and storage change. Given observations of rainfall and runoff, and remote-sensing-based observations of evaporation, the ratio (?) between estimated daily evaporation from recession analysis and observed evaporation, and the ratio (?) between estimated contributing storage and total watershed storage are computed for 9 watersheds located in different climate regions. Both evaporation and storage change estimation from recession analysis are underestimated due to the effect of partial contributing storage, particularly when the discharge is low. It was found that the values of ? decrease significantly during individual recession events, while the values of ? are relatively stable during a recession event. The values of ? are negatively correlated with the water table depth and vary significantly among recession events. The partial contributing storage effect is one possible cause for the multi-valued storage-discharge relationship.

Chen, X.; Wang, D.

2013-10-01

283

Partial wave analysis of the reaction ?p?p? and the search for nucleon resonances  

NASA Astrophysics Data System (ADS)

An event-based partial wave analysis (PWA) of the reaction ?p?p? has been performed on a high-statistics dataset obtained using the CLAS at Jefferson Lab for center-of-mass energies from threshold up to 2.4 GeV. This analysis benefits from access to the world’s first high-precision spin-density matrix element measurements, available to the event-based PWA through the decay distribution of ???+?-?0. The data confirm the dominance of the t-channel ?0 exchange amplitude in the forward direction. The dominant resonance contributions are consistent with the previously identified states F15(1680) and D13(1700) near threshold, as well as the G17(2190) at higher energies. Suggestive evidence for the presence of a JP=5/2+ state around 2 GeV, a “missing” state, has also been found. Evidence for other states is inconclusive.

Williams, M.; Applegate, D.; Bellis, M.; Meyer, C. A.; Adhikari, K. P.; Anghinolfi, M.; Baghdasaryan, H.; Ball, J.; Battaglieri, M.; Bedlinskiy, I.; Berman, B. L.; Biselli, A. S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Careccia, S. L.; Carman, D. S.; Cole, P. L.; Collins, P.; Crede, V.; D'Angelo, A.; Daniel, A.; de Vita, R.; de Sanctis, E.; Deur, A.; Dey, B.; Dhamija, S.; Dickson, R.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dugger, M.; Dupre, R.; Alaoui, A. El; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fradi, A.; Gabrielyan, M. Y.; Garçon, M.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Hassall, N.; Hicks, K.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jawalkar, S. S.; Jo, H. S.; Johnstone, J. R.; Joo, K.; Keller, D.; Khandaker, M.; Khetarpal, P.; Kim, W.; Klein, A.; Klein, F. J.; Krahn, Z.; Kubarovsky, V.; Kuleshov, S. V.; Kuznetsov, V.; Livingston, K.; Lu, H. Y.; Mayer, M.; McAndrew, J.; McCracken, M. E.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Moreno, B.; Moriya, K.; Morrison, B.; Munevar, E.; Nadel-Turonski, P.; Nepali, C. S.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niroula, M. R.; Niyazov, R. A.; Osipenko, M.; Ostrovidov, A. I.; Paris, M.; Park, K.; Park, S.; Pasyuk, E.; Pereira, S. Anefalos; Perrin, Y.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Protopopescu, D.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salamanca, J.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seraydaryan, H.; Sharabian, Y. G.; Smith, E. S.; Sober, D. I.; Sokhan, D.; Stepanyan, S. S.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tedeschi, D. J.; Tkachenko, S.; Ungaro, M.; Vineyard, M. F.; Voutier, E.; Watts, D. P.; Weygand, D. P.; Wood, M. H.; Zhang, J.; Zhao, B.

2009-12-01

284

An eQTL Analysis of Partial Resistance to Puccinia hordei in Barley  

PubMed Central

Background Genetic resistance to barley leaf rust caused by Puccinia hordei involves both R genes and quantitative trait loci. The R genes provide higher but less durable resistance than the quantitative trait loci. Consequently, exploring quantitative or partial resistance has become a favorable alternative for controlling disease. Four quantitative trait loci for partial resistance to leaf rust have been identified in the doubled haploid Steptoe (St)/Morex (Mx) mapping population. Further investigations are required to study the molecular mechanisms underpinning partial resistance and ultimately identify the causal genes. Methodology/Principal Findings We explored partial resistance to barley leaf rust using a genetical genomics approach. We recorded RNA transcript abundance corresponding to each probe on a 15K Agilent custom barley microarray in seedlings from St and Mx and 144 doubled haploid lines of the St/Mx population. A total of 1154 and 1037 genes were, respectively, identified as being P. hordei-responsive among the St and Mx and differentially expressed between P. hordei-infected St and Mx. Normalized ratios from 72 distant-pair hybridisations were used to map the genetic determinants of variation in transcript abundance by expression quantitative trait locus (eQTL) mapping generating 15685 eQTL from 9557 genes. Correlation analysis identified 128 genes that were correlated with resistance, of which 89 had eQTL co-locating with the phenotypic quantitative trait loci (pQTL). Transcript abundance in the parents and conservation of synteny with rice allowed us to prioritise six genes as candidates for Rphq11, the pQTL of largest effect, and highlight one, a phospholipid hydroperoxide glutathione peroxidase (HvPHGPx) for detailed analysis. Conclusions/Significance The eQTL approach yielded information that led to the identification of strong candidate genes underlying pQTL for resistance to leaf rust in barley and on the general pathogen response pathway. The dataset will facilitate a systems appraisal of this host-pathogen interaction and, potentially, for other traits measured in this population.

Chen, Xinwei; Hackett, Christine A.; Niks, Rients E.; Hedley, Peter E.; Booth, Clare; Druka, Arnis; Marcel, Thierry C.; Vels, Anton; Bayer, Micha; Milne, Iain; Morris, Jenny; Ramsay, Luke; Marshall, David; Cardle, Linda; Waugh, Robbie

2010-01-01

285

Heart rate changes in partial seizures: analysis of influencing factors among refractory patients  

PubMed Central

Background We analyzed the frequency of heart rate (HR) changes related to seizures, and we sought to identify the influencing factors of these changes during partial seizures, to summarize the regularity of the HR changes and gain some insight into the mechanisms involved in the neuronal regulation of cardiovascular function. To date, detailed information on influencing factors of HR changes related to seizures by multiple linear regression analysis remains scarce. Methods Using video-electroencephalograph (EEG)-electrocardiograph (ECG) recordings, we retrospectively assessed the changes in the HR of 81 patients during a total of 181 seizures, including 27 simple partial seizures (SPS), 110 complex partial seizures (CPS) and 44 complex partial seizures secondarily generalized (CPS-G). The epileptogenic focus and the seizure type, age, gender, and sleep/wakefulness state of each patient were evaluated during and after the seizure onset. The HR changes were evaluated in the stage of epilepsy as time varies. Results Of the 181 seizures from 81 patients with ictal ECGs, 152 seizures (83.98%) from 74 patients were accompanied by ictal tachycardia (IT). And only 1 patient was accompanied by ictal bradycardia (IB). A patient has both IT and IB. We observed that HR difference was independently correlated with side, type and sleep/wakefulness state. In this analysis, the HR changes were related to the side, gender, seizure type, and sleep/wakefulness state. Right focus, male, sleep, and CPS-G showed more significant increases than that were observed in left, female, wakefulness, SPS and CPS. HR increases rapidly within 10 seconds before seizure onset and ictus, and typically slows to normal with seizure offset. Conclusion CPS-G, sleep and right focus led to higher ictal HR. The HR in the stage of epilepsy has regularly been observed to change to become time-varying. The risk factors of ictal HR need to be controlled along with sleep, CPS-G and right focus. Our study first explains that the HR in seizures has a regular evolution varying with time. Our study might help to further clarify the basic mechanisms of interactions between heart and brain, making seizure detection and closed-loop systems a possible therapeutic alternative in refractory patients.

2014-01-01

286

Safety and performance analysis of a commercial photovoltaic installation  

NASA Astrophysics Data System (ADS)

Continuing to better understand the performance of PV systems and changes in performance with the system life is vital to the sustainable growth of solar. A systematic understanding of degradation mechanisms that are induced as a result of variables such as the service environment, installation, module/material design, weather, operation and maintenance, and manufacturing is required for reliable operation throughout a system's lifetime. We wish to report the results from an analysis of a commercial c-Si PV array owned and operated by DuPont. We assessed the electrical performance of the modules by comparing the original manufacturers' performance data with the measurements obtained using a solar simulator to determine the degradation rate. This evaluation provides valuable PV system field experience and document key issues regarding safety and performance. A review of the nondestructive and destructive analytical methods and characterization strategies we have found useful for system, module, and subsequent material component evaluations are presented. We provide an overview of our inspection protocol and subsequent control process to mitigate risk. The objective is to explore and develop best practice protocols regarding PV asset optimization and provide a rationale to reduce risk based on the analysis of our own commercial installations.

Hamzavy, Babak T.; Bradley, Alexander Z.

2013-09-01

287

Integration of partial least squares and Monte Carlo gene expression analysis in coronary artery disease  

PubMed Central

Coronary artery disease (CAD) is the most common type of cardiovascular disease and leading cause of mortality worldwide. Microarray technology for gene expression analysis has facilitated the identification of the molecular mechanism that underlies the pathogenesis of CAD. Previous studies have primarily used variance or regression analysis, without considering array specific factors. Thus, the aim of the present study was to investigate the mechanism of CAD using partial least squares (PLS)-based analysis, which was integrated with the Monte Carlo technique. Microarray analysis was performed with a data set of 110 CAD patients and 111 controls obtained from the Gene Expression Omnibus database. A total of 390 dysregulated genes were acquired. Significantly increased representations of dysregulated genes in Gene Ontology items, including transforming growth factor ?-activated receptor activity and acyl-CoA oxidase activity, were identified. Network analysis revealed three hub genes with a degree of >10, including ESR1, ITGA4 and ARRB2. The results of the present study provide novel information on the gene expression signatures of CAD patients and offer further theoretical support for future therapeutic study.

ZHANG, HUAN; LI, TAO; WU, GUANJI; MA, FENG

2014-01-01

288

School Safety, Severe Disciplinary Actions, and School Characteristics: A Secondary Analysis of the School Survey on Crime and Safety  

ERIC Educational Resources Information Center

On the basis of a secondary analysis of survey data collected from 1,872 secondary school principals in the 2005-2006 School Survey on Crime and Safety, we examined the frequency of and reasons for severe disciplinary actions and the relationship between school characteristics and severe disciplinary actions. We found that severe disciplinary…

Han, Seunghee; Akiba, Motoko

2011-01-01

289

Development of Quantitative Risk Analysis tool for the fire safety in railway tunnel  

Microsoft Academic Search

In the context of strengthening fire safety level in the transport tunnel, much effort has been made to develop techniques to quantify the fire risk in the transport tunnel system. In this paper, the development of quantitative risk analysis tool for the fire safety in railway tunnel will be described. Inside the analysis tool, a number of scenarios are constructed

Sungwook Yoon; Hang Choi

290

Improvement of Fault Tree Analysis in Formal Safety Assessment Using Binary Decision Diagram  

Microsoft Academic Search

International Maritime Organization (IMO) implements the principles of risk management through a systematic process called Formal Safety Assessment (FSA). FSA is a structured and systematic methodology, aimed at enhancing maritime safety, including protection of life, health, the marine environment and property, by using risk analysis and cost benefit assessment. One of the most widely used hazard identification and risk analysis

Yao Cai; Zhengjiang Liu; Zhaolin Wu

2009-01-01

291

Providing Nuclear Criticality Safety Analysis Education through Benchmark Experiment Evaluation  

SciTech Connect

One of the challenges that today's new workforce of nuclear criticality safety engineers face is the opportunity to provide assessment of nuclear systems and establish safety guidelines without having received significant experience or hands-on training prior to graduation. Participation in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and/or the International Reactor Physics Experiment Evaluation Project (IRPhEP) provides students and young professionals the opportunity to gain experience and enhance critical engineering skills.

John D. Bess; J. Blair Briggs; David W. Nigg

2009-11-01

292

Robotic versus Open Partial Nephrectomy: A Systematic Review and Meta-Analysis  

PubMed Central

Objectives To critically review the currently available evidence of studies comparing robotic partial nephrectomy (RPN) and open partial nephrectomy (OPN). Materials and Methods A comprehensive review of the literature from Pubmed, Web of Science and Scopus was performed in October 2013. All relevant studies comparing RPN with OPN were included for further screening. A cumulative meta-analysis of all comparative studies was performed and publication bias was assessed by a funnel plot. Results Eight studies were included for the analysis, including a total of 3418 patients (757 patients in the robotic group and 2661 patients in the open group). Although RPN procedures had a longer operative time (weighted mean difference [WMD]: 40.89; 95% confidence interval [CI], 14.39–67.40; p?=?0.002), patients in this group benefited from a lower perioperative complication rate (19.3% for RPN and 29.5% for OPN; odds ratio [OR]: 0.53; 95%CI, 0.42–0.67; p<0.00001), shorter hospital stay (WMD: ?2.78; 95%CI, ?3.36 to ?1.92; p<0.00001), less estimated blood loss(WMD: ?106.83; 95%CI, ?176.4 to ?37.27; p?=?0.003). Transfusions, conversion to radical nephrectomy, ischemia time and estimated GFR change, margin status, and overall cost were comparable between the two techniques. The main limitation of the present meta-analysis is the non-randomization of all included studies. Conclusions RPN appears to be an efficient alternative to OPN with the advantages of a lower rate of perioperative complications, shorter length of hospital stay and less blood loss. Nevertheless, high quality prospective randomized studies with longer follow-up period are needed to confirm these findings.

Cai, Chen; Ye, Huamao; Lv, Chen; Yang, Qing; Sheng, Jing; Song, Shangqing; Qu, Le; Xiao, Liang; Sun, Yinghao; Wang, Linhui

2014-01-01

293

Eye-safety analysis of infrared laser imaging for security surveillance  

NASA Astrophysics Data System (ADS)

Eye-safety analysis is very important in the civil application of infrared laser imaging. In order to meet the requirements of human eye-safety protection, a model of eye-safety analysis is established based on ANSI Z136.1 Standard. When the value of maximum permissible exposure is given, one can estimate laser power and beam divergence angle under desired eye-safety distances from the model. We have simulated the model by MATLAB and given the laser power curve at different distances. Based on the curve, the eye-safety parameters of laser imaging systems can be easily designed. Therefore, the proposed model of eye-safety analysis can help to standardize infrared laser imaging products.

Yang, Jiaqi; Wang, Xinwei; Shi, Xiaoguang; Zhou, Yan

2011-11-01

294

ES and H Manual: Environment, Safety, and Health. Volume V. Part 51: Safety Analysis, Limits and Authorization. Document 51.1 Documented Safety Analysis Program Plan.  

National Technical Information Service (NTIS)

LLNLs Integrated Safety Management System (ISMS) requires that the control of hazards be identified before conducting work. The safety basis development process formalizes the elements of the required identification and description of controls. This docum...

2003-01-01

295

PARTIAL LEAST SQUARES IS TO LISREL AS PRINCIPAL COMPONENTS ANALYSIS IS TO COMMON FACTOR ANALYSIS  

Microsoft Academic Search

The decision of whether to use PLS instead of a covariance based structural equation modeling technique such as LISREL for causal modeling can be assisted by looking at the differences between principal components analysis and common factor analysis. Through such a process, this paper outlines the need for PLS users to shift from merely estimating model parameters to that of

Wynne W. Chin

296

An analysis of human performance in simulated partial-gravity environments  

NASA Technical Reports Server (NTRS)

Three unique partial gravity test environments; parabolic flight, water immersion and a mechanical-relief device provide the environment to evaluate human locomotion, reach sweeps, and posture in the reduced gravity levels of the moon (1/6) and Mars (3/8). The development of a motion analysis database for 1/6 and 3/8 gravity environments as well as an initial understanding of human motion in low gravity environments are the focus of these experiments. Each of the three partial-gravity simulations provided a unique environment with some specific limitations. Water immersion provides a continuous testing environment but must factor in the effects of water viscosity drag, subject weighting, and breathing apparatus. Parabolic flight provides the most realistic testing environment although the test must be interrupted every 40 seconds to execute a complete parabolic maneuver of the aircraft. Mechanical force relief systems also provide uninterrupted testing. However, the body support harness necessary for use of mechanical force relief systems can potentially hinder test subject movement. By using the test results generated from all three test arenas, the Man-Systems Division will create a database of human locomotion specific to the lunar and Mars gravity environments. The information gathered is being used to enhance the development and design of future human habitation elements.

Moore, Nathan R.; Gutierrez, David J.

1992-01-01

297

Packaging Review Guide for Reviewing Safety Analysis Reports for Packagings  

SciTech Connect

This Packaging Review Guide (PRG) provides guidance for Department of Energy (DOE) review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE Order 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his or her review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. This PRG is generally organized at the section level in a format similar to that recommended in Regulatory Guide 7.9 (RG 7.9). One notable exception is the addition of Section 9 (Quality Assurance), which is not included as a separate chapter in RG 7.9. Within each section, this PRG addresses the technical and regulatory bases for the review, the manner in which the review is accomplished, and findings that are generally applicable for a package that meets the approval standards. This Packaging Review Guide (PRG) provides guidance for DOE review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE O 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. The primary objectives of this PRG are to: (1) Summarize the regulatory requirements for package approval; (2) Describe the technical review procedures by which DOE determines that these requirements have been satisfied; (3) Establish and maintain the quality and uniformity of reviews; (4) Define the base from which to evaluate proposed changes in scope and requirements of reviews; and (5) Provide the above information to DOE organizations, contractors, other government agencies, and interested members of the general public. This PRG was originally published in September 1987. Revision 1, issued in October 1988, added new review sections on quality assurance and penetrations through the containment boundary, along with a few other items. Revision 2 was published October 1999. Revision 3 of this PRG is a complete update, and supersedes Revision 2 in its entirety.

DiSabatino, A; Biswas, D; DeMicco, M; Fisher, L E; Hafner, R; Haslam, J; Mok, G; Patel, C; Russell, E

2007-04-12

298

Navier-Stokes Flow Field Analysis of Compressible Flow in a High Pressure Safety Relief Valve.  

National Technical Information Service (NTIS)

The objective of this study is to investigate the complex three-dimensional flowfield of an oxygen safety pressure relieve valve during an incident, with a computational fluid dynamic (CFD) analysis. Specifically, the analysis will provide a flow pattern ...

B. Vu T. Wang M. Shih B. Soni

1993-01-01

299

Use and Interpretation of Confidence and Tolerance Intervals in Safety Analysis.  

National Technical Information Service (NTIS)

The statistical concepts of tolerance and confidence are reviewed, with particular reference to the presentation of quantitative probability based arguments as applied in safety analysis. The increasing difficulty in performing a meaningful analysis when ...

G. W. Parry P. Shaw D. H. Worledge

1977-01-01

300

Regional frequency analysis of extreme rainfalls using partial L moments method  

NASA Astrophysics Data System (ADS)

An approach based on regional frequency analysis using L moments and LH moments are revisited in this study. Subsequently, an alternative regional frequency analysis using the partial L moments (PL moments) method is employed, and a new relationship for homogeneity analysis is developed. The results were then compared with those obtained using the method of L moments and LH moments of order two. The Selangor catchment, consisting of 37 sites and located on the west coast of Peninsular Malaysia, is chosen as a case study. PL moments for the generalized extreme value (GEV), generalized logistic (GLO), and generalized Pareto distributions were derived and used to develop the regional frequency analysis procedure. PL moment ratio diagram and Z test were employed in determining the best-fit distribution. Comparison between the three approaches showed that GLO and GEV distributions were identified as the suitable distributions for representing the statistical properties of extreme rainfall in Selangor. Monte Carlo simulation used for performance evaluation shows that the method of PL moments would outperform L and LH moments methods for estimation of large return period events.

Zakaria, Zahrahtul Amani; Shabri, Ani

2013-07-01

301

[Failure mechanisms in the transfusion process. Importance of anticipatory operational safety analysis].  

PubMed

The methods used for the safety previsional analysis of operations represent an interesting set of tools to follow the so-called transfusion process, defined as all the steps from donors sensitization to recipients follow-up. FMECA (Failure Mode Effects and Criticality Analysis) can be used as a prevention tool, independently of any dysfunction in the process. Of course, it can also be used following a failure, in order to analyse its causes and to apply specific corrections. Operation safety, quality insurance, epidemiologic surveillance and safety monitoring act in synergy. These three aspects of transfusion safety constitute a dynamic system. PMID:7812465

Hergon, E; Crespeau, H; Rouger, P

1994-01-01

302

Application of Computer Integration Technology for Fire Safety Analysis  

Microsoft Academic Search

With the development of information technology, the fire safety assessment of whole structure or region based on the computer simulation has become a hot topic. However, traditionally, the concerned studies are performed separately for different objectives and difficult to perform an overall evaluation. A new multi-dimensional integration model and methodology for fire safety assessment were presented and two newly developed

Jianyong Shi; Yinqing Li; Huchuan Chen

2008-01-01

303

Numerical solution of a model for nuclear reactor safety analysis  

Microsoft Academic Search

A mathematical model for the Ames Laboratory Research Reactor and proposed safety device electronics is presented, the method of solution is discussed, and results are graphed and tabulated. The model is comprised of a nonlinear system of nineteen differential equations. A derivation of the three ordinary differential equations which describe the safety electronics unique to this project is given. Three

M. J. Strasburger; H. D. Skank

1976-01-01

304

Adversarial safety analysis: Borrowing the methods of security vulnerability assessments  

Microsoft Academic Search

Introduction: Safety and security share numerous attributes. The author, who heads the (Security) Vulnerability Assessment Team at Los Alamos National Laboratory, therefore argues that techniques used to optimize security might be useful for optimizing safety. Optimizing Security: There are three main ways to attempt to improve security—security surveys, risk assessment (or “design basis threat”), and vulnerability assessments. The latter is

Roger G Johnston

2004-01-01

305

Detection of partial discharge in power transformers using Rogowski coil and multiresolution analysis  

Microsoft Academic Search

Partial discharge detection in power transformers is discussed using a new approach that exploit the broad band of the Rogowski coils and the potential of two signal processing tools: discrete wavelet transform and empirical mode decomposition. Detecting and analyzing incipient activities of partial discharge can provide useful information to diagnostics and prognostics about transformer insulation. So, partial discharge signals embedded

Giscard F. C. Veloso; L. E. B. da Silva; I. Noronha; G. L. Torres; J. Haddad; R. R. Pereira; Se Un Ahn

2009-01-01

306

Biomechanical analysis of bursal-sided partial thickness rotator cuff tears  

Microsoft Academic Search

Background: Treatment of partial thickness supraspinatus tendon tears is controversial with no clearly defined treatment algorithms based on severity of tears. This study aims to evaluate the relationship between depth of partial thickness tears and strain. Methods: Bursal-sided partial thickness tears were created at 1 mm increments in depth at the anterior portion of the supraspinatus tendon to 3\\/4 tendon

Scott Yang; Hyung-Soon Park; Steven Flores; Steven D. Levin; Mohsen Makhsous; Fang Lin; Jason Koh; Gordon Nuber; Li-Qun Zhang

2009-01-01

307

Elastic scattering of electrons and positrons by atoms. Schrödinger and Dirac partial wave analysis  

NASA Astrophysics Data System (ADS)

Two FORTRAN 77 codes are described which provide a complete description of elastic scattering of electrons and positrons by atoms using the static field approximation with non-relativistic (Schrödinger) and relativistic (Dirac) partial wave analysis. The delivered information includes phase shifts, differential cross-sections, scattering amplitudes and percentage points of the single scattering angular distribution. The scattering field may be internally generated by the codes (which incorporate an accurate analytical approximation to the Dirac-Hartree-Fock-Slater field of free atoms) or read from the input file. Solid state effects for scattering in solids are described by means of a simple muffin-tin model. For electron scattering, exchange corrections are also taken into account. Phase shifts are obtained by using the RADWEQ subroutine package [Comput. Phys. Commun. 62 (1991) 65] to solve the radial equations. The relativistic code provides reliable cross-section data for kinetic energies between ? 1 keV and ? 1 MeV.

Salvat, Francesc; Mayol, Ricardo

1993-03-01

308

Partial Wave Analysis at BES III, harnessing the power of GPUs  

NASA Astrophysics Data System (ADS)

Partial wave analysis (PWA) is a core tool for determining resonance properties in hadron spectroscopy. The unbinned likelihood fits employed are however computationally very expensive especially in view of the very large data samples being collected at the Beijing Spectrometer (BES) III experiment and expected from future experiments such as Glue-X and PANDA. Using the power of massively parallel floating point calculations on graphics processing units (GPUs), we have managed to speed up PWA by more than two orders of magnitude compared to legacy implementations. The resulting software framework allows for the fast creation and running of PWA code. Modern hardware and software thus solve the PWA speed problems--many questions concerning fit methods and especially the reliability of fit results however remain open.

Berger, Niklaus

2011-10-01

309

Note: Multivariate system spectroscopic model using Lorentz oscillators and partial least squares regression analysis  

NASA Astrophysics Data System (ADS)

Multivariate system spectroscopic model plays important role in understanding chemometrics of ensemble under study. Here in this manuscript we discuss various approaches of modeling of spectroscopic system and demonstrate how Lorentz oscillator can be used to model any general spectroscopic system. Chemometric studies require customized templates design for the corresponding variants participating in ensemble, which generates the characteristic matrix of the ensemble under study. The typical biological system that resembles human blood tissue consisting of five major constituents i.e., alanine, urea, lactate, glucose, ascorbate; has been tested on the model. The model was validated using three approaches, namely, root mean square error (RMSE) analysis in the range of +/-5% confidence interval, clerk gird error plot, and RMSE versus percent noise level study. Also the model was tested across various template sizes (consisting of samples ranging from 10 up to 1000) to ascertain the validity of partial least squares regression. The model has potential in understanding the chemometrics of proteomics pathways.

Gad, R. S.; Parab, J. S.; Naik, G. M.

2010-11-01

310

Hydroelastic vibration analysis of partially liquid-filled shells using a series representation of the liquid  

NASA Technical Reports Server (NTRS)

A series representation of the oscillatory behavior of incompressible nonviscous liquids contained in partially filled elastic tanks is presented. Each term is selected on the basis of hydroelastic vibrations in circular cylindrical tanks. Using a complementary energy principle, the superposition of terms is made to approximately satisfy the liquid-tank interface compatibility. This analysis is applied to the gravity sloshing and hydroelastic vibrations of liquids in hemispherical tanks and in a typical elastic aerospace propellant tank. With only a few series terms retained, the results correlate very well with existing analytical results, NASTRAN-generated analytical results, and experimental test results. Hence, although each term is based on a cylindrical tank geometry, the superposition can be successfully applied to noncylindrical tanks.

Housner, J. M.; Herr, R. W.; Sewall, J. L.

1980-01-01

311

Fast Flux Test Facility final safety analysis report. Amendment 72  

SciTech Connect

This document provides the Final Safety Analysis Report (FSAR) Amendment 72 for incorporation into the Fast Flux Test Facility (FFTF) FSAR set. This amendment change incorporates Engineering Change Notices issued subsequent to Amendment 71 and approved for incorporation before June 24, 1992. These include changes in: Chapter 2, Site Characteristics; Chapter 3, Design Criteria Structures, Equipment, and Systems; Chapter 5B, Reactor Coolant System; Chapter 7, Instrumentation and Control Systems; Chapter 8, Electrical Systems - The description of the Class 1E, 125 Vdc systems is updated for the higher capacity of the newly installed, replacement batteries; Chapter 9, Auxiliary Systems - The description of the inert cell NASA systems is corrected to list the correct number of spare sample points; Chapter 11, Reactor Refueling System; Chapter 12, Radiation Protection and Waste Management; Chapter 13, Conduct of Operations; Chapter 16, Quality Assurance; Chapter 17, Technical Specifications; Chapter 19, FFTF Fire Specifications for Fire Detection, Alarm, and Protection Systems; Chapter 20, FFTF Criticality Specifications; and Appendix B, Primary Piping Integrity Evaluation.

Gantt, D.A.

1992-08-01

312

Soft Mathematical Aggregation in Safety Assessment and Decision Analysis  

SciTech Connect

This paper improves on some of the limitations of conventional safety assessment and decision analysis methods. It develops a top-down mathematical method for expressing imprecise individual metrics as possibilistic or fuzzy numbers and shows how they may be combined (aggregated) into an overall metric, also portraying the inherent uncertainty. Both positively contributing and negatively contributing factors are included. Metrics are weighted according to significance of the attribute and evaluated as to contribution toward the attribute. Aggregation is performed using exponential combination of the metrics, since the accumulating effect of such factors responds less and less to additional factors. This is termed soft mathematical aggregation. Dependence among the contributing factors is accounted for by incorporating subjective metrics on overlap of the factors and by correspondingly reducing the overall contribution of these combinations to the overall aggregation. Decisions corresponding to the meaningfulness of the results are facilitated in several ways. First, the results are compared to a soft threshold provided by a sigmoid function. Second, information is provided on input ''Importance'' and ''Sensitivity,'' in order to know where to place emphasis on controls that may be necessary. Third, trends in inputs and outputs are tracked in order to add important information to the decision process. The methodology has been implemented in software.

Cooper, J. Arlin

1999-06-10

313

Culture of Safety in Hospitals: A Three-Part Analysis of Safety Culture, Evidence-Based Practice Guidelines, and Patient Outcomes  

Microsoft Academic Search

Sammer, Christine E., Culture of Safety in Hospitals: A Three-Part Analysis of Safety Culture, Evidence-Based Practice Guidelines, and Patient Outcomes. Doctor of Public Health (Health Management and Policy), December 2009, 101 pp., 10 tables, 1 figure, references, 115 titles.\\u000aThis research is a three-part study of the culture of patient safety, evidence-based practice, and patient safety outcomes within the U.S.

Christine Sammer

2009-01-01

314

Automated validation of patient safety clinical incident classification: macro analysis.  

PubMed

Patient safety is the buzz word in healthcare. Incident Information Management System (IIMS) is electronic software that stores clinical mishaps narratives in places where patients are treated. It is estimated that in one state alone over one million electronic text documents are available in IIMS. In this paper we investigate the data density available in the fields entered to notify an incident and the validity of the built in classification used by clinician to categories the incidents. Waikato Environment for Knowledge Analysis (WEKA) software was used to test the classes. Four statistical classifier based on J48, Naïve Bayes (NB), Naïve Bayes Multinominal (NBM) and Support Vector Machine using radial basis function (SVM_RBF) algorithms were used to validate the classes. The data pool was 10,000 clinical incidents drawn from 7 hospitals in one state in Australia. In first part of the study 1000 clinical incidents were selected to determine type and number of fields worth investigating and in the second part another 5448 clinical incidents were randomly selected to validate 13 clinical incident types. Result shows 74.6% of the cells were empty and only 23 fields had content over 70% of the time. The percentage correctly classified classes on four algorithms using categorical dataset ranged from 42 to 49%, using free-text datasets from 65% to 77% and using both datasets from 72% to 79%. Kappa statistic ranged from 0.36 to 0.4. for categorical data, from 0.61 to 0.74. for free-text and from 0.67 to 0.77 for both datasets. Similar increases in performance in the 3 experiments was noted on true positive rate, precision, F-measure and area under curve (AUC) of receiver operating characteristics (ROC) scores. The study demonstrates only 14 of 73 fields in IIMS have data that is usable for machine learning experiments. Irrespective of the type of algorithms used when all datasets are used performance was better. Classifier NBM showed best performance. We think the classifier can be improved further by reclassifying the most confused classes and there is scope to apply text mining tool on patient safety classifications. PMID:23823288

Gupta, Jaiprakash; Patrick, Jon

2013-01-01

315

T-Hulls, Discretization, and Partially Ordered Sets in Molecular Shape Analysis  

NASA Astrophysics Data System (ADS)

T-Hulls are a generalization of Alpha-Hulls, where the reference to shape analysis is not a single curvature value, but the complete shape of a reference object T. Whereas T-Hulls provide a generalization of convexity theorems and are versatile tools for molecular shape analysis and shape analysis in general for objects in arbitrary dimensions, they are also tools for discretization of shape description as well as for transformations between continuous and discrete models with the aid of a single continuous parameter. This continuous parameter generates an ordering of shapes and if a finite number of such transformations are considered, for example, with reference to a combination of several molecular properties, then a partial ordering is obtained. This special property can be exploited in the molecular context if our goal is the establishment of rigorous connections between quantum chemical and discrete mathematical (such as graph theoretical) models used for molecular characterization in applied fields, such as QSAR or pharmaceutical drug design.

Mezey, Paul G.

2009-08-01

316

Partial least-squares calibration diagnostics applied to the FT-IR analysis of borophosphosilicate glass (BPSG) thin films  

SciTech Connect

Full-spectrum multivariate calibration methods are capable of providing a multitude of diagnostic capabilities for evaluating the quality of the calibration, identifying problem calibration samples, and flagging unknown samples whose analysis by these methods might be unreliable. These diagnostics are demonstrated for the analysis of BPSG thin films on silicon using infrared spectroscopy and partial least-squares methods. 3 refs., 1 fig.

Haaland, D.M.

1989-01-01

317

Automatic safety analysis of networked control system based on failure propagation model  

Microsoft Academic Search

Recent developments in the modern control systems show a clear trend for increasing integration of a number of safety-related electronic systems - such as railway siganlling system and x-by-wire systems - that are replacing traditional mechanical controls. These applications promise improved performance and safety through continuous high-capacity real- time data exchanges and reconfiguration in abnormal situations. However, safety analysis of

Ru Niu; Tao Tang; Oleg Lisagor; John McDermid

2011-01-01

318

ACCIDENT ANALYSES & CONTROL OPTIONS IN SUPPORT OF THE SLUDGE WATER SYSTEM SAFETY ANALYSIS  

Microsoft Academic Search

This report documents the accident analyses and nuclear safety control options for use in Revision 7 of HNF-SD-WM-SAR-062, ''K Basins Safety Analysis Report'' and Revision 4 of HNF-SD-SNF-TSR-001, ''Technical Safety Requirements - 100 KE and 100 KW Fuel Storage Basins''. These documents will define the authorization basis for Sludge Water System (SWS) operations. This report follows the guidance of DOE-STD-3009-94,

2003-01-01

319

In-space propellant systems safety. Volume 3: System safety analysis  

NASA Technical Reports Server (NTRS)

The primary objective was to examine from a system safety viewpoint in-space propellant logistic elements and operations to define the potential hazards and to recommend means to reduce, eliminate or control them. A secondary objective was to conduct trade studies of specific systems or operations to determine the safest of alternate approaches.

1972-01-01

320

Epilepsy (partial)  

PubMed Central

Introduction About 3% of people will be diagnosed with epilepsy during their lifetime, but about 70% of people with epilepsy eventually go into remission. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of starting antiepileptic drug treatment following a single seizure? What are the effects of drug monotherapy in people with partial epilepsy? What are the effects of additional drug treatments in people with drug-resistant partial epilepsy? What is the risk of relapse in people in remission when withdrawing antiepileptic drugs? What are the effects of behavioural and psychological treatments for people with epilepsy? What are the effects of surgery in people with drug-resistant temporal lobe epilepsy? We searched: Medline, Embase, The Cochrane Library, and other important databases up to July 2009 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 83 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy).

2011-01-01

321

Neuronal networks in west syndrome as revealed by source analysis and renormalized partial directed coherence.  

PubMed

West syndrome is a severe epileptic encephalopathy of infancy with a poor developmental outcome. This syndrome is associated with the pathognomonic EEG feature of hypsarrhythmia. The aim of the study was to describe neuronal networks underlying hypsarrhythmia using the source analysis method (dynamic imaging of coherent sources or DICS) which represents an inverse solution algorithm in the frequency domain. In order to investigate the interaction within the detected network, a renormalized partial directed coherence (RPDC) method was also applied as a measure of the directionality of information flow between the source signals. Both DICS and RPDC were performed for EEG delta activity (1-4 Hz) in eight patients with West syndrome and in eight patients with partial epilepsies (control group). The brain area with the strongest power in the given frequency range was defined as the reference region. The coherence between this reference region and the entire brain was computed using DICS. After that, the RPDC was applied to the source signals estimated by DICS. The results of electrical source imaging were compared to results of a previous EEG-fMRI study which had been carried out using the same cohort of patients. As revealed by DICS, delta activity in hypsarrhythmia was associated with coherent sources in the occipital cortex (main source) as well as the parietal cortex, putamen, caudate nucleus and brainstem. In patients with partial epilepsies, delta activity could be attributed to sources in the occipital, parietal and sensory-motor cortex. In West syndrome, RPDC showed the strongest and most significant direction of ascending information flow from the brainstem towards the putamen and cerebral cortex. The neuronal network underlying hypsarrhythmia in this study resembles the network which was described in previous EEG-fMRI and PET studies with involvement of the brainstem, putamen and cortical regions in the generation of hypsarrhythmia. The RPDC suggests that brainstem could have a key role in the pathogenesis of West syndrome. This study supports the theory that hypsarrhythmia results from ascending brainstem pathways that project widely to basal ganglia and cerebral cortex. PMID:23011408

Japaridze, Natia; Muthuraman, Muthuraman; Moeller, Friederike; Boor, Rainer; Anwar, Abdul Rauf; Deuschl, Günther; Stephani, Urlich; Raethjen, Jan; Siniatchkin, Michael

2013-01-01

322

Preliminary Preclosure Safety Analysis for a Prospective Yucca Mountain Repository.  

National Technical Information Service (NTIS)

A quantitative probabilistic safety assessment was performed for the reference conceptual repository design being used as the basis for the development of the Yucca Mountain Site Characterization Plan. A new methodology to quantify radioactive source term...

L. J. Jardine C. W. Ma R. C. Sit R. J. Donahue

1987-01-01

323

A Chemical Plant Safety and Hazard Analysis Course.  

ERIC Educational Resources Information Center

Describes a course for teaching chemical engineering students about safety and hazards. Summarizes the course content including topics for term papers and disciplines related to this course. Lists 18 references. (YP)

Gupta, J. P.

1989-01-01

324

Safety analysis of optically ignited explosive and pyrotechnic devices.  

National Technical Information Service (NTIS)

The future of optical ordnance depends on the acceptance, validation and verification of the stated safety enhancement claims of optical ordnance over existing electrical explosive devices (EED's). Sandia has been pursuing the development of optical ordna...

J. A. Merson F. J. Salas S. Holswade

1994-01-01

325

Probabilistic Safety Analysis Procedures Guide. Sections 1 - 7 and Appendices.  

National Technical Information Service (NTIS)

A procedures guide for the performance of probabilistic safety assessment has been prepared for interim use in the Nuclear Regulatory Commission programs. It will be revised as comments are received, and as experience is gained from its use. The probabili...

R. A. Bari A. J. Buslik N. Z. Cho A. El-Bassioni J. Fragola

1985-01-01

326

Review and Analysis of Community Traffic Safety Programs. Volume 1.  

National Technical Information Service (NTIS)

Community Traffic Safety Programs (CTSPs) have emerged largely during the 1980s. There are currently well over 300. Each has developed differently, based on local needs and resources and on the technical direction and financial support received from NHTSA...

W. A. Leaf D. F. Preusser

1994-01-01

327

Markov Modeling with Soft Aggregation for Safety and Decision Analysis  

SciTech Connect

The methodology in this report improves on some of the limitations of many conventional safety assessment and decision analysis methods. A top-down mathematical approach is developed for decomposing systems and for expressing imprecise individual metrics as possibilistic or fuzzy numbers. A ''Markov-like'' model is developed that facilitates combining (aggregating) inputs into overall metrics and decision aids, also portraying the inherent uncertainty. A major goal of Markov modeling is to help convey the top-down system perspective. One of the constituent methodologies allows metrics to be weighted according to significance of the attribute and aggregated nonlinearly as to contribution. This aggregation is performed using exponential combination of the metrics, since the accumulating effect of such factors responds less and less to additional factors. This is termed ''soft'' mathematical aggregation. Dependence among the contributing factors is accounted for by incorporating subjective metrics on ''overlap'' of the factors as well as by correspondingly reducing the overall contribution of these combinations to the overall aggregation. Decisions corresponding to the meaningfulness of the results are facilitated in several ways. First, the results are compared to a soft threshold provided by a sigmoid function. Second, information is provided on input ''Importance'' and ''Sensitivity,'' in order to know where to place emphasis on considering new controls that may be necessary. Third, trends in inputs and outputs are tracked in order to obtain significant information% including cyclic information for the decision process. A practical example from the air transportation industry is used to demonstrate application of the methodology. Illustrations are given for developing a structure (along with recommended inputs and weights) for air transportation oversight at three different levels, for developing and using cycle information, for developing Importance and Sensitivity measures for soil aggregation, for developing dependence methodology, for constructing early alert logic, for tracking trends, for relating the Markov model to other (e.g., Reason) models, for developing and demonstrating rudimentary laptop software, and for developing an input/output display methodology.

COOPER,J. ARLIN

1999-09-01

328

Partially independent component analysis of tumor heterogeneities by DCE-MRI  

NASA Astrophysics Data System (ADS)

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) has emerged as an effective tool to access tumor vascular characteristics. DCE-MRI can be used to characterize noninvasively, microvasculature providing information about tumor microvessel structure and function (e.g., tumor blood volume, vascular permeability, tumor perfusion). However, pixels of DCE-MRI represent a composite of more than one distinct functional biomarker (e.g., microvessels with fast or slow perfusion) whose spatial distributions are often heterogeneous. Complementary to various existing methods (e.g., compartment modeling, factor analysis), this paper proposes a blind source separation method which allows for a computed simultaneous imaging of multiple biomarkers from composite DCE-MRI sequences. The algorithm is based on a partially-independent component analysis, whose parameters are estimated using a subset of informative pixels defining the independent portion of the observations. We demonstrate the principle of the approach on simulated image data set, and we then apply the method to the tissue heterogeneity characterization of breast tumors where spatial distribution of tumor blood volume, vascular permeability, and tumor perfusion, as well as their time activity curves (TACs) are simultaneously estimated.

Zhang, JunYing; Srikanchana, Rujirutana; Xuan, Jianhua; Choyke, Peter; Li, King; Wang, Yue J.

2003-05-01

329

Reliability Modeling Methodology for Independent Approaches on Parallel Runways Safety Analysis  

NASA Technical Reports Server (NTRS)

This document is an adjunct to the final report An Integrated Safety Analysis Methodology for Emerging Air Transport Technologies. That report presents the results of our analysis of the problem of simultaneous but independent, approaches of two aircraft on parallel runways (independent approaches on parallel runways, or IAPR). This introductory chapter presents a brief overview and perspective of approaches and methodologies for performing safety analyses for complex systems. Ensuing chapter provide the technical details that underlie the approach that we have taken in performing the safety analysis for the IAPR concept.

Babcock, P.; Schor, A.; Rosch, G.

1998-01-01

330

Methodology study on event-tree analysis for ULOF sequences considering passive safety features.  

National Technical Information Service (NTIS)

In order to establish a method of probabilistic safety analysis for passive safety features, the event-tree (E/T) of ULOF accident sequences in the early stage of accident progression was constructed for an 600 MWe LMFBR model plant equipped with passive ...

T. Mihara H. Niwa

1998-01-01

331

Preliminary Safety Analysis Report and Design Review of the 2 KW(e) Radioisotope Thermoelectric Generator.  

National Technical Information Service (NTIS)

A Preliminary Safety Analysis Report (PSAR) and Design Review have been conducted for the 2 KW(e) Radioisotope Thermoelectric Generator (RTG). The objective of the PSAR was to appraise the risk to public health and safety resulting from the handling, tran...

1975-01-01

332

Food safety, Hazard Analysis and Critical Control Point and the increase in foodborne diseases: a paradox?  

Microsoft Academic Search

The application of the Hazard Analysis and Critical Control Point (HACCP) system is rapidly progressing, in particular in large and medium scale food industries. The term is becoming well known in food control and public health circles and is one which evokes food safety. However, concomitant with the headway of the HACCP system in food safety management, the incidence of

Yasmine Motarjemi; Fritz Käferstein

1999-01-01

333

Evaluation of the coal industrial safety: Based on the data envelopment analysis  

Microsoft Academic Search

Coal industrial safety is important for the coal industry to develop healthily. In this paper the Data Envelopment Analysis model is applied to evaluate the coal industrial safety in China. The evaluation result shows the coal industry is basic safe at the present time and in the near future. The coal industry can develop more safely by improving the competitiveness,

Wei-da He; Ping Lu; Kai Zhang; Yu-ping Wu

2011-01-01

334

Hydrogen Safety Project chemical analysis support task: Window ``C`` volatile organic analysis  

SciTech Connect

This data package contains the results obtained by Pacific Northwest Laboratory (PNL) staff in the characterization of samples for the 101-SY Hydrogen Safety Project. The samples were submitted for analysis by Westinghouse Hanford Company (WHC) under the Technical Project Plan (TPP) 17667 and the Quality Assurance Plan MCS-027. They came from a core taken during Window ``C`` after the May 1991 gas release event. The analytical procedures required for analysis were defined in the Test Instructions (TI) prepared by the PNL 101-SY Analytical Chemistry Laboratory (ACL) Project Management Office in accordance with the TPP and the QA Plan. The requested analysis for these samples was volatile organic analysis. The quality control (QC) requirements for each sample are defined in the Test Instructions for each sample. The QC requirements outlined in the procedures and requested in the WHC statement of work were followed.

Gillespie, B.M.; Stromatt, R.W.; Ross, G.A.; Hoope, E.A.

1992-01-01

335

Hydrogen Safety Project chemical analysis support task: Window C'' volatile organic analysis  

SciTech Connect

This data package contains the results obtained by Pacific Northwest Laboratory (PNL) staff in the characterization of samples for the 101-SY Hydrogen Safety Project. The samples were submitted for analysis by Westinghouse Hanford Company (WHC) under the Technical Project Plan (TPP) 17667 and the Quality Assurance Plan MCS-027. They came from a core taken during Window C'' after the May 1991 gas release event. The analytical procedures required for analysis were defined in the Test Instructions (TI) prepared by the PNL 101-SY Analytical Chemistry Laboratory (ACL) Project Management Office in accordance with the TPP and the QA Plan. The requested analysis for these samples was volatile organic analysis. The quality control (QC) requirements for each sample are defined in the Test Instructions for each sample. The QC requirements outlined in the procedures and requested in the WHC statement of work were followed.

Gillespie, B.M.; Stromatt, R.W.; Ross, G.A.; Hoope, E.A.

1992-01-01

336

Analysis of a superconducting stripline by the method of partial regions  

NASA Astrophysics Data System (ADS)

The application of the method of partial regions to a superconducting microstripline makes it possible to obtain a rigorous solution of the boundary value problem. This method also yields approximate relationships for calculating kinetic inductance with an accuracy sufficient for practical engineering applications. Unlike the commonly used grid method, the method of partial regions does not require the use of a powerful computer.

Veselov, G. I.; Platonov, N. I.; Smirnova, O. V.

1986-02-01

337

Analysis of conditions of partial discharges inception and development at non-sinusoidal testing voltages  

Microsoft Academic Search

Progress in construction of electrical insulation systems needs new investigations of partial discharges (PD) mechanisms. Working conditions and exploitation stresses, i.e. overvoltages, harmonics and other disturbances have crucial influence on arising of PD in insulation systems. Their influence on partial discharge development is different from normal conditions at nominal sinusoidal voltage. In such a cases interpretation of measurement results (by

Barbara Florkowska; Pawel Zydron

2006-01-01

338

Interpretation of wavelet analysis and its application in partial discharge detection  

Microsoft Academic Search

The objective of the paper is to discuss a tool which is proving extremely efficient in partial discharge measurement studies. Though the technique itself is not new, its application to partial discharge studies is. It will be demonstrated in this paper that it has tremendous power and this accounts for its rapid growth as an application in this field. The

X. Ma; Chengke Zhou; I. J. Kemp

2002-01-01

339

Intrinsic Hamiltonian symmetry group structure analysis for orthogonal partial symmetry decomposition  

NASA Astrophysics Data System (ADS)

In this paper the partial symmetry method in the intrinsic nuclear frame is analyzed to obtain physical partial symmetries from the so-called formal symmetries of intrinsic sub-Hamiltonians. Derivation of the physical symmetries is illustrated by an example that shows in a detailed way the symmetry structure of the corresponding energy spectra of the total Hamiltonian.

P?drak, A.; Gó?d?, A.

2014-05-01

340

An improved detection technique for measurement and analysis of partial discharges  

Microsoft Academic Search

The measurement of partial discharges may be achieved using very different detection techniques. In classical systems, based on band pass filtering, there is a lack of very important information: the value of the applied voltage which induce the discharge and the time instant in which it occurs. A different approach is based on separation of the partial discharge signal from

Edoardo Carminati; Massho Lazzaroni

1996-01-01

341

Behavioral Assessment, Analysis, and Support in a Psychiatric Partial Hospitalization Program for Adults with Developmental Disabilities  

Microsoft Academic Search

This article describes the objectives and operations of a behavioral psychology service within a partial hospitalization program for adults with psychiatric disorders and developmental disabilities. Partial hospitalization programs are an effective model of psychiatric service delivery but are not common for patients with mental retardation\\/mental illness. Phases of intake behavioral assessment, treatment planning and implementation, and discharge are described with

James K. Luiselli; Kathleen Lisowski; Robin Weiss

1998-01-01

342

The Oak Ridge Research Reactor: safety analysis: Volume 2, supplement 2  

SciTech Connect

The Oak Ridge Research Reactor Safety Analysis was last updated via ORNL-4169, Vol. 2, Supplement 1, in May of 1978. Since that date, several changes have been effected through the change-memo system described below. While these changes have involved the cooling system, the electrical system, and the reactor instrumentation and controls, they have not, for the most part, presented new or unreviewed safety questions. However, some of the changes have been based on questions or recommendations stemming from safety reviews or from reactor events at other sites. This paper discusses those changes which were judged to be safety related and which include revisions to the syphon-break system and changes related to seismic considerations which were very recently completed. The maximum hypothetical accident postulated in the original safety analysis requires dynamic containment and filtered flow for compliance with 10CFR100 limits at the site boundary.

Hurt, S.S.

1986-11-01

343

Safety Analysis of High Pressure 3He-filled Micro-channels for Thermal Neutron Detection.  

National Technical Information Service (NTIS)

This document is a safety analysis of a novel neutron detection technology developed by Sandia National Laboratories. This technology is comprised of devices with tiny channels containing high pressure (sup 3)He. These devices are further integrated into ...

M. S. Derzon P. C. Galambos R. F. Renzi S. M. Ferko

2008-01-01

344

Safety Analysis Report: X17B2 beamline Synchrotron Medical Research Facility  

SciTech Connect

This report contains a safety analysis for the X17B2 beamline synchrotron medical research facility. Health hazards, risk assessment and building systems are discussed. Reference is made to transvenous coronary angiography. (LSP)

Gmuer, N.F.; Thomlinson, W.

1990-02-01

345

Stability analysis of partially loaded Leipholz column carrying a lumped mass and resting on elastic foundation  

NASA Astrophysics Data System (ADS)

In the present study, the stability of a cantilever column resting on an elastic foundation under the action of a uniformly distributed tangential load is discussed. A Winkler type elastic foundation is considered. Moreover, the effect of a lumped mass located in an arbitrary position on the stability of the system when the column is subjected to a partially distributed follower force is investigated. The equations of motion are obtained using the extended Hamilton's principle and the influences of the lumped mass and applied load are included in the equations using the generalized functions theories. Applying the Ritz technique, the resulting equations are transformed into a general eigenvalue problem. The effects of several design parameters such as foundation elastic modulus, ratio of the lumped mass to the column's mass, position of the lumped mass and the distribution model of the follower force are examined. The validity of the present analysis is confirmed by comparing the results with those obtained in literature and excellent agreement is observed. The numerical results reveal that the load distribution length and model have significant effects on the flutter boundaries of the system.

Fazelzadeh, S. A.; Kazemi-Lari, M. A.

2013-02-01

346

PCA of PCA: principal component analysis of partial covering absorption in NGC 1365  

NASA Astrophysics Data System (ADS)

We analyse 400 ks of XMM-Newton data on the active galactic nucleus NGC 1365 using principal component analysis (PCA) to identify model-independent spectral components. We find two significant components and demonstrate that they are qualitatively different from those found in MCG-6-30-15 using the same method. As the variability in NGC 1365 is known to be due to changes in the parameters of a partial covering neutral absorber, this shows that the same mechanism cannot be the driver of variability in MCG-6-30-15. By examining intervals where the spectrum shows relatively low absorption we separate the effects of intrinsic source variability, including signatures of relativistic reflection, from variations in the intervening absorption. We simulate the principal components produced by different physical variations, and show that PCA provides a clear distinction between absorption and reflection as the drivers of variability in AGN spectra. The simulations are shown to reproduce the PCA spectra of both NGC 1365 and MCG-6-30-15, and further demonstrate that the dominant cause of spectral variability in these two sources requires a qualitatively different mechanism.

Parker, M. L.; Walton, D. J.; Fabian, A. C.; Risaliti, G.

2014-06-01

347

Radioisotopic neutron transmission spectrometry: Quantitative analysis by using partial least-squares method.  

PubMed

Neutron spectrometry, based on the scattering of high energy fast neutrons from a radioisotope and slowing-down by the light hydrogen atoms, is a useful technique for non-destructive, quantitative measurement of hydrogen content because it has a large measuring volume, and is not affected by temperature, pressure, pH value and color. The most common choice for radioisotope neutron source is (252)Cf or (241)Am-Be. In this study, (252)Cf with a neutron flux of 6.3x10(6)n/s has been used as an attractive neutron source because of its high flux neutron and weak radioactivity. Pulse-height neutron spectra have been obtained by using in-house built radioisotopic neutron spectrometric system equipped with (3)He detector and multi-channel analyzer, including a neutron shield. As a preliminary study, polyethylene block (density of approximately 0.947g/cc and area of 40cmx25cm) was used for the determination of hydrogen content by using multivariate calibration models, depending on the thickness of the block. Compared with the results obtained from a simple linear calibration model, partial least-squares regression (PLSR) method offered a better performance in a quantitative data analysis. It also revealed that the PLSR method in a neutron spectrometric system can be promising in the real-time, online monitoring of the powder process to determine the content of any type of molecules containing hydrogen nuclei. PMID:19285419

Kim, Jong-Yun; Choi, Yong Suk; Park, Yong Joon; Jung, Sung-Hee

2009-01-01

348

Raman spectroscopy and partial least squares analysis in discrimination of peripheral cells affected by Huntington's disease.  

PubMed

Huntington's disease (HD) is a neurodegenerative disorder caused by trinucleotide CAG (Cytosine-Adenine-Guanine) expansion on the Huntingtin gene (HTT) encoding for the Huntingtin protein (Htt). The protein has been linked in peripheral fibroblasts with dysregulation of cellular components which are part of lipid rafts in plasma membrane sub-domains. Therefore the analysis of the plasma membrane might be a useful diagnostic biomarker for the detection of the presence and possible onset of HD in readily accessible peripheral cells. Here Raman spectroscopy has been used with a chemometric approach in the form of Partial Least Square (PLS) for an initial corroboration that the plasma membrane is indeed a sub-cellular biomarker discriminator for HD identification. Observations were made in the spectral regions from 400 to 1800 cm(-1) and 2700 to 3200 cm(-1) with the former region displaying the most significant differences and peak displacement between plasma membranes extracted from HD and control fibroblast cells. The major differences in plasma membrane composition reside in sub-cellular elements putatively associated to cholesterol, phospholipids (mainly phophatidylinositol) as well as proteins containing tyrosine. These findings are indicative of the plasma membrane as an amenable biomarker for HD for further in vitro research with possible applications in vivo models. PMID:23953200

Muratore, M

2013-09-01

349

Breakpoint analysis of Turner patients with partial Xp deletions: implications for the lymphoedema gene location  

PubMed Central

BACKGROUND—Turner syndrome is characterised by a 45,X karyotype and a variety of skeletal, lymphoedemic, and gonadal anomalies. Genes involved in the Turner phenotype are thought to be X/Y homologous with the X genes escaping X inactivation. Haploinsufficiency of the SHOX gene has been reported to cause the short stature seen in Turner syndrome patients. More recently, mutations of this gene have been shown to be associated with other skeletal abnormalities, suggesting that haploinsufficiency of SHOX causes all the Turner skeletal anomalies. No such gene has yet been identified for the lymphoedemic features.?METHODS—Fluorescence in situ hybridisation (FISH) analysis with PAC clones on nine patients with partially deleted X chromosomes was performed.?RESULTS/DISCUSSION—The Turner syndrome stigmata for each patient are described and correlation between the breakpoint and the phenotype discussed. A lymphoedema critical region in Xp11.4 is proposed and its gene content discussed with respect to that in the previously reported Yp11.2 lymphoedema critical region.???Keywords: Turner syndrome; lymphoedema; Xp11.4

Boucher, C.; Sargent, C.; Ogata, T.; Affara, N.

2001-01-01

350

Multichannel Analysis of Surface Waves and Dam Safety  

NASA Astrophysics Data System (ADS)

Geophysical methodologies and particularly the Multichannel Analysis of Surface Waves (MASW) effectively proved their efficiency in the non-destructive testing of the dams, in the last decade, after many successful applications worldwide. The MASW method developed in the outset of this decade considerably improved the prospects and the validity of these geophysical applications. Since MASW and the other geophysical techniques do not require drilling they progressively increased their popularity significantly. The Multichannel Analysis of Surface Waves can be applied for the assessment of both earthen and concrete dams. Nevertheless, mostly cases of earthen dams can be found in the literature. The method can detect and map low shear wave velocity areas potentially associated with low cohesion zones due to differential settlement events in the core or increased seepage. The advantage of MASW is that it is not influenced by the water saturation of the interior of the dam contrary to other methods eg. p-wave tomography. Usually, a joint application of MASW with the p-wave techniques can be an optimal choice since the two methodologies can act complementary. An application of MASW on a three-dimensional structure, such as a dam, however, can actually be considered as a complicated problem since the effects of the lateral structural anomalies can strongly affect the results. For example, in an earthen dam the investigation of the core can be influenced by the presence of the shells. Therefore, the problem should be carefully examined by modeling all these the lateral anomalies with the aim to avoid a misinterpretation of the results. The effectiveness of MASW to the dam safety assessment is presented through two example applications, one at the Mornos Dam, an earthen dam responsible for the water supply of Athens, and a second one at the Marathon Dam which is a concrete dam also used for the water supply of Athens. In the case of Mornos Dam, MASW detected areas affected by the differential settlement of the dam and more specifically by the arching phenomenon in the core. Such phenomena can lead to hydraulic fracture in the core and therefore should be carefully encountered. In particular the method detected, in the central part of the core, a weak zone just below the crest and another one at depth of 45 below crest, at a place where the monitoring instruments of the dam had measured very low effective stresses. This zone follows the shape pattern of the riverbed and at the edges of the crest it is connected with two other thick tensile zones. The example from the application in the concrete dam at Marathon is focused on the interior of the dam. The data acquired there, in the tunnels, were of different character than the ones gathered on usual applications on soil environment mainly due to the high and broad frequency content and the high phase velocity values. The standard data acquisition procedure also required some modification for the triggering and recording. The analysis of the data showed that such an application could provide useful results for the testing of the concrete quality.

Karastathis, V. K.

2012-12-01

351

Considering consumers' food safety perceptions at the WTO -level: a survey-based analysis  

Microsoft Academic Search

Abstract The WTO frame for food safety policy follows the structure of risk analysis, i.e. consists of rules re- garding the three components of risk assessment, management and communication. The analysis of the WTO rules and of the findings of closed disputes identifies a strong orientation on science as well asan,approach ,to harmonise ,food safety standards by basing,them on the

Bettina Rudloff; Johannes Simons

352

[Efficacy and safety of levetiracetam as adjunctive therapy in Japanese children with uncontrolled partial-onset seizures: multicenter and open-label study (N01223), short term evaluation].  

PubMed

A multicenter, open-label, single-armed study (N01223) was conducted to evaluate efficacy and safety of levetiracetam (LEV) as an add-on therapy in Japanese pediatric patients with uncontrolled partial-onset seizures (POS). A total of 73 children aged 4-15 years (mean±SD=10.1±3.4 years) were enrolled in the study, which consisted of an 8-week baseline period and a 14-week treatment period, including a 4-week titration period. A historical placebo control from a pivotal overseas pediatric study in POS add-on therapy was used. A 16.3% median percent reduction from the baseline in POS was observed in this placebo control. Therefore, in the present study, this value (16.3%) was chosen as the predefined threshold for the lower limit of the 95% confident interval (95% CI) of the median percent reduction from the baseline for LEV. In the present study, the percentage reduction (95% CI) in POS during the treatment period was 43.21% (26.19-52.14%), indicating a beneficial impact of LEV. The incidences of treatment-emergent adverse events (TEAEs) and adverse drug reactions (ADRs) were 82.2% (60/73 cases) and 56.2% (41/73 cases), respectively. The most common TEAEs were somnolence, nasopharyngitis, upper respiratory tract infection, and pyrexia. Frequent ADRs (more than 3%) were somnolence and feeling jittery. No serious TEAE or death was reported during the study. Our results suggested that adjunctive therapy with LEV is clinically efficacious and well tolerated in Japanese children with uncontrolled POS. PMID:24018745

Nakamura, Hidefumi; Osawa, Makiko; Yokoyama, Terumichi; Yoshida, Katsumi; Suzuki, Atsushi

2013-09-01

353

A Comparison of Approaches for the Analysis of Interaction Effects between Latent Variables Using Partial Least Squares Path Modeling  

ERIC Educational Resources Information Center

In social and business sciences, the importance of the analysis of interaction effects between manifest as well as latent variables steadily increases. Researchers using partial least squares (PLS) to analyze interaction effects between latent variables need an overview of the available approaches as well as their suitability. This article…

Henseler, Jorg; Chin, Wynne W.

2010-01-01

354

Linear coupled analysis of desiccation shrinkage in a double-layer partially saturated medium: semi-explicit solutions  

Microsoft Academic Search

Solutions are presented for the problem of isothermal dessiccation shrinkage in a double-layer porous partially saturated medium. The rheological model taken into account is linear poroelastic. Hence the analysis is mainly focused on hydromechanical coupling effects and contrasts of mechanical and hydraulic properties between two materials: a low thickness skin comprised between the outer boundary and the reference porous material.

G. Thouvenin; A. Giraud; F. Homand

2001-01-01

355

COMPARISON OF THE METHODS FOR ANALYSIS OF PARTIAL SAMPLES AND OF A BULK SAMPLE AT ESTIMATING WEED SEEDBANK IN SOIL  

Microsoft Academic Search

Summary The effect of soil sampling with three core samplers of a different diameter (13, 64, and 80 mm) using the method for analysis of partial samples (MAPS) or a bulk sample (MABS) on the precision of estimating the weed seedbank in soil was studied in a model experiment. The results show that to obtain sufficiently exact data characterising the

Vladimír SMUTNÝ

356

Combined genetic analysis of partial blast resistance in an upland rice population and recurrent selection for line and hybrid values  

Microsoft Academic Search

The CNA-IRAT 5 upland rice population has been improved for 4 years by recurrent selection for blast resistance in Brazil. In order to predict the efficiency of recurrent selection in different test systems and to compare the relative advantage of hybrids versus pure line breeding, a combined genetic analysis of partial blast resistance in the CNA-IRAT 5 population was undertaken.

S. Veillet; M. C. Filippi; A. Gallais

1996-01-01

357

Dynamic analysis of laminated composite plates subjected to transverse impact using a partial mixed 3-D finite element  

Microsoft Academic Search

This study uses a partial mixed 3-D finite element in the impact dynamic analysis of laminated composite plates subjected to circularly distributed impact loading of a small, cylindrically shaped, blunt-ended projectile. The contact force between the rigid projectile and the laminated plate is modeled by the Hertzian contact law. To solve the finite element equations of motion in the impact

C.-L. Liao; J.-S. Tsai

1994-01-01

358

Sensitivity analysis of radiative transfer for atmospheric remote sensing in thermal IR: atmospheric weighting functions and surface partials  

NASA Technical Reports Server (NTRS)

In this presentation, we apply the adjoint sensitivity analysis of radiative transfer in thermal IR to the general case of the analytic evaluation of the weighting functions of atmospheric parameters together with the partial derivatives for the surface parameters. Applications to remote sensing of atmospheres of Mars and Venus are discussed.

Ustinov, E. A.

2003-01-01

359

Safety analysis report for the Tritium Systems Test Assembly  

Microsoft Academic Search

One of the primary objectives of the Tritium Systems Test Assembly is to demonstrate that the technologies associated with the DT fuel cycle for a fusion reactor can be operated safely and operated with minimal environmental impact. During the design and construction phase, safety analyses were performed to investigate the effects of normal operations, of component failure, of operational failures,

1983-01-01

360

An Analysis of Farm Injuries and Safety Practices in Mississippi  

Microsoft Academic Search

In Mississippi, agriculture is the most dangerous industry employing over 30% of the state's workforce. Records from the Mississippi Cooperative Extension Service indicated that 18 tractor deaths occurred in 1997, a new all-time record. Also, there were two additional deaths involving other farm machinery. This study was designed to determine the magnitude of farm injuries, safety practices, and educational programs

Carey L. Ford; Terence L. Lynch

2000-01-01

361

Statistical analysis on current status of China forest fire safety  

Microsoft Academic Search

In China, forests are a very rare natural resource. Forest fires happen frequently and the loss is very serious each year. In this paper, statistical data on forest fires in China are analyzed in order to reveal new features regarding the forest fire safety situation as the economy of China is growing. The causes of forest fires in China are

Maohua Zhong; Weicheng Fan; Tiemin Liu; Peide Li

2003-01-01

362

Safety Stock Analysis in a MultiLevel Inventory System  

Microsoft Academic Search

In this paper a model is presented for determination of the expected annual total cost of inventory for a multi-level inventory system. The model permits identification of the safety stock levels needed to minimize the expected annual total cost for a multi-level inventory system, such as distributed warehouses. An example of the application of the model is given.

M. K. Salameh; J. W. Schmidt

1984-01-01

363

Safety analysis of the main vault at TA41, LASL  

Microsoft Academic Search

Safety considerations discussed in this report show that special nuclear materials stored at a Los Alamos Scientific Laboratory facility (TA-41) present no inappropriate risk to workers or the public. The report addresses nuclear criticality, fire, and radioactive contamination potentials, as well as physical protection and material safeguards.

T. E. Ehrenkranz; D. A. Dahl; E. H. Plassmann; R. Pogna; D. R. Smith

1978-01-01

364

Sample Size and Power Analysis for Endometrial Safety Studies  

Microsoft Academic Search

Endometrial safety studies are required for the approval of progestin components. The Committee for Proprietary Medicinal Products requirement is the actual percentage below 2% and the upper limit of the one-sided exact 95% confidence interval not more than 2% above the point estimate. The more recent U.S. Food and Drug Administration requirement is the actual percentage  ? 1% and the upper

Guoqin Su

2005-01-01

365

Risk analysis as a basis for safety management system  

Microsoft Academic Search

The paper shows, with a practical application, how the hazard identification and evaluation phase of the Safety Management System (SMS) in a major risk installation (as defined by EC Directive CEE 96\\/82 (Seveso II) is the sizing criteria for the whole SMS, with its procedures. Probabilistic risk assessment techniques are applied to a foaming agent production plant. The links between

Micaela Demichela; Norberto Piccinini; Alfredo Romano

2004-01-01

366

Analysis of factors influencing safety management for metro construction in China.  

PubMed

With the rapid development of urbanization in China, the number and size of metro construction projects are increasing quickly. At the same time, and increasing number of accidents in metro construction make it a disturbing focus of social attention. In order to improve safety management in metro construction, an investigation of the participants' perspectives on safety factors in China metro construction has been conducted to identify the key safety factors, and their ranking consistency among the main participants, including clients, consultants, designers, contractors and supervisors. The result of factor analysis indicates that there are five key factors which influence the safety of metro construction including safety attitude, construction site safety, government supervision, market restrictions and task unpredictability. In addition, ANOVA and Spearman rank correlation coefficients were performed to test the consistency of the means rating and the ranking of safety factors. The results indicated that the main participants have significant disagreement about the importance of safety factors on more than half of the items. Suggestions and recommendations on practical countermeasures to improve metro construction safety management in China are proposed. PMID:23932091

Yu, Q Z; Ding, L Y; Zhou, C; Luo, H B

2014-07-01

367

Surface-based functional magnetic resonance imaging analysis of partial brain echo planar imaging data at 1.5 T  

Microsoft Academic Search

Surface-based functional magnetic resonance imaging (fMRI) analysis is more sensitive and accurate than volume-based analysis for detecting neural activation. However, these advantages are less important in practical fMRI experiments with commonly used 1.5-T magnetic resonance devices because of the resolution gap between the echo planar imaging data and the cortical surface models. We expected high-resolution segmented partial brain echo planar

Hang Joon Jo; Jong-Min Lee; Jae-Hun Kim; Chi-Hoon Choi; Do-Hyung Kang; Jun Soo Kwon; Sun I. Kim

2009-01-01

368

Oak Ridge National Laboratory site data for safety-analysis report  

SciTech Connect

The Oak Ridge National Laboratory site data contained herein were compiled in support of the United States Department of Energy (USDOE) Oak Ridge Operations Office Order OR 5481.1. That order sets forth assignment of responsibilities for safety analysis and review responsibilities and provides guidance relative to the content and format of safety analysis reports. The information presented in this document is intended for use by reference in individual safety analysis reports where applicable to support accident analyses or the establishment of design bases of significance to safety, and it is applicable only to Oak Ridge National Laboratory facilities in Bethel and Melton Valleys. This information includes broad descriptions of the site characteristics, radioactive waste handling and monitoring practices, and the organization and operating policies at Oak Ridge National Laboratory. The historical background of the Laboratory is discussed briefly and the overall physical situation of the facilities is described in the following paragraphs.

Fitzpatrick, F.C.

1982-12-01

369

ACCIDENT ANALYSES & CONTROL OPTIONS IN SUPPORT OF THE SLUDGE WATER SYSTEM SAFETY ANALYSIS  

SciTech Connect

This report documents the accident analyses and nuclear safety control options for use in Revision 7 of HNF-SD-WM-SAR-062, ''K Basins Safety Analysis Report'' and Revision 4 of HNF-SD-SNF-TSR-001, ''Technical Safety Requirements - 100 KE and 100 KW Fuel Storage Basins''. These documents will define the authorization basis for Sludge Water System (SWS) operations. This report follows the guidance of DOE-STD-3009-94, ''Preparation Guide for US. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports'', for calculating onsite and offsite consequences. The accident analysis summary is shown in Table ES-1 below. While this document describes and discusses potential control options to either mitigate or prevent the accidents discussed herein, it should be made clear that the final control selection for any accident is determined and presented in HNF-SD-WM-SAR-062.

WILLIAMS, J.C.

2003-11-15

370

Analysis of the Interaction of Partially Polarized Light with Dielectric Plates.  

National Technical Information Service (NTIS)

The paper is concerned with a matrix formulation and solution of the interaction of partially polarized light with transparent dielectric plates. Fresnel's equations for transmission and reflection at a dielectric interface are expressed in the form of Mu...

E. Collett

1971-01-01

371

Interuser Interference Analysis for Direct-Sequence Spread-Spectrum Systems Part I: Partial-Period Cross-Correlation  

NASA Technical Reports Server (NTRS)

This presentation discusses an analysis approach to evaluate the interuser interference for Direct-Sequence Spread-Spectrum (DSSS) Systems for Space Network (SN) Users. Part I of this analysis shows that the correlation property of pseudo noise (PN) sequences is the critical factor which determines the interuser interference performance of the DSSS system. For non-standard DSSS systems in which PN sequence s period is much larger than one data symbol duration, it is the partial-period cross-correlation that determines the system performance. This study reveals through an example that a well-designed PN sequence set (e.g. Gold Sequence, in which the cross-correlation for a whole-period is well controlled) may have non-controlled partial-period cross-correlation which could cause severe interuser interference for a DSSS system. Since the analytical derivation of performance metric (bit error rate or signal-to-noise ratio) based on partial-period cross-correlation is prohibitive, the performance degradation due to partial-period cross-correlation will be evaluated using simulation in Part II of this analysis in the future.

Ni, Jianjun (David)

2012-01-01

372

Analysis of partial discharge signal using the Hilbert-Huang transform  

Microsoft Academic Search

The development of time-frequency and time-scale transforms has progressed rapidly over the last 20 years. The development and progression of numerical acquisition enable the utilization of these mathematical tools to analyze partial discharge in electrical equipment. This paper introduces a new transform, a Hilbert-Huang Transform to analyze partial discharge data. The mathematical model of a Hilbert-Huang Transform is described; and

Xiaodong Wang; Baoqing Li; Zhiwei Liu; Harry T. Roman; Onofrio L. Russo; Ken K. Chin; Kenneth R. Farmer

2006-01-01

373

Element-free Galerkin (EFG) method for analysis of the time-fractional partial differential equations  

Microsoft Academic Search

The present paper deals with the numerical solution of time-fractional partial differential equations using the element-free Galerkin (EFG) method, which is based on the moving least-square approximation. Compared with numerical methods based on meshes, the EFG method for time-fractional partial differential equations needs only scattered nodes instead of meshing the domain of the problem. It neither requires element connectivity nor

Ge Hong-Xia; Liu Yong-Qing; Cheng Rong-Jun

2012-01-01

374

Preliminary Safety Analysis of Conceptual Hybrid, Repowering, and Retrofit Applications of Solar-Thermal Central-Receiver Technology.  

National Technical Information Service (NTIS)

A preliminary safety analysis was undertaken for fifteen conceptual designs of hybrid, repowering/retrofit applications of solar thermal central receiver technology. The approach was generic in nature and focused on safety concerns associated with the phy...

P. R. Hurt R. G. Lindberg

1982-01-01

375

Pantex Plant final safety analysis report, Zone 4 magazines. Staging or interim storage for nuclear weapons and components: Issue D.  

National Technical Information Service (NTIS)

This Safety Analysis Report (SAR) contains a detailed description and evaluation of the significant environmental, safety, and health (ES&H) issues associated with the operations of the Pantex Plant modified-Richmond and steel arch construction (SAC) maga...

1993-01-01

376

Framework for Cost-Benefit Analysis of the Dutch Road Safety Plan (Opplegg for Nytte-Kostnadsanalyse av Nederlands Trafikksikkerhetsplan).  

National Technical Information Service (NTIS)

The report describes a framework for cost-benefit analysis of the Dutch road safety plan. it discusses the concept of sustainable safety and estimates revised road accident costs for the Netherlands. The effects of various measures is discussed. Examples ...

R. Elvik

1997-01-01

377

Analysis and modification of amorphous and partially-crystalline thin films  

SciTech Connect

Thin films of light atomic weight elements in amorphous, partially-crystalline, or crystalline forms have applications in a broad range of technologies. For example, amorphous tetrahedral carbon (a-tC) and polymeric thin films impact electronic materials technology as electron- and light-emitting device elements, respectively. A lack of crystallinity introduces complexity in the experimental and theoretical characterization of these materials but is not necessarily a limiting factor in their performance. While the growth process is clearly a major factor governing the physical properties of a film, interactions with the substrate are also important, so surface and interface analysis provides an important complement to bulk measurements. This paper focuses on several approaches in the characterization and modification of thin films made possible by recent experimental advances. The structural and electronic properties of two model systems are considered as examples: a-tC thin films grown by pulsed laser deposition (PLD) and polyaniline thin films grown by vapor deposition. First, scanning probe microscopies and X-ray scattering are used to investigate the structural aspects of a-tC films as a function of PLD growth conditions. The possible connection of nanoscale surface modification and characterization with electron emission properties will be discussed. Second, the results of inelastic scattering spectroscopy and other surface techniques will be discussed to obtain information on both interfacial aspects of the growth of polyaniline thin films and microscopic and macroscopic aspects of electrical conductivity upon doping. Comparisons will be made with other studies that address properties of analogous crystalline systems as appropriate. A brief assessment of the broader problem of analyzing these systems will be given.

DiNardo, N.J.; Mercer, T.W. [Drexel Univ., Philadelphia, PA (United States). Dept. of Physics; Martinez-Miranda, L.J. [Univ. of Maryland, College Park, MD (United States). Dept. of Materials and Nuclear Engineering; Siegal, M.P.; Friedmann, T.A.; Sullivan, J.R. [Sandia National Labs., Albuquerque, NM (United States); Plank, R.V.; Vohs, J.M. [Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Chemical Engineering

1997-12-01

378

Analysis of developed transition road safety barrier systems.  

PubMed

Road safety barriers protect vehicles from roadside hazards by redirecting errant vehicles in a safe manner as well as providing high levels of safety during and after impact. This paper focused on transition safety barrier systems which were located at the point of attachment between a bridge and roadside barriers. The aim of this study was to provide an overview of the behavior of transition systems located at upstream bridge rail with different designs and performance levels. Design factors such as occupant risk and vehicle trajectory for different systems were collected and compared. To achieve this aim a comprehensive database was developed using previous studies. The comparison showed that Test 3-21, which is conducted by impacting a pickup truck with speed of 100 km/h and angle of 25° to transition system, was the most severe test. Occupant impact velocity and ridedown acceleration for heavy vehicles were lower than the amounts for passenger cars and pickup trucks, and in most cases higher occupant lateral impact ridedown acceleration was observed on vehicles subjected to higher levels of damage. The best transition system was selected to give optimum performance which reduced occupant risk factors using the similar crashes in accordance with Test 3-21. PMID:23820073

Soltani, Mehrtash; Moghaddam, Taher Baghaee; Karim, Mohamed Rehan; Sulong, N H Ramli

2013-10-01

379

Safety Analysis Report for Packaging (SARP): USA\\/5790\\/BLF (ERDA-AL) and USA\\/5791\\/BLF (ERDA-AL)  

Microsoft Academic Search

The Safety Analysis Report for Packaging (SARP) satisfies the request of the U. S. Energy Research and Development Administration for a formal safety analysis of the two insulated drum shipping containers identified as USA\\/5790\\/BLF ERDA-AL and USA\\/5791\\/BLF ERDA-AL. Discussions of structural integrity, thermal resistance, radiation shielding and radiological safety, nuclear criticality safety, and quality control are included. Much of the

J. F. Griffin; R. E. Bertram; R. K. Blauvelt; D. A. Edling; T. M. Flanagan; J. B. Peterson; D. L. Prosser

1976-01-01

380

Dynamic analysis of laminated composite plates subjected to transverse impact using a partial mixed 3-D finite element  

NASA Astrophysics Data System (ADS)

This study uses a partial mixed 3-D finite element in the impact dynamic analysis of laminated composite plates subjected to circularly distributed impact loading of a small, cylindrically shaped, blunt-ended projectile. The contact force between the rigid projectile and the laminated plate is modeled by the Hertzian contact law. To solve the finite element equations of motion in the impact dynamic analysis, the Newmark direct integration scheme is employed to discretize the time domain. At the beginning of each time step, since the contact force is still unknown, the Newton-Raphson method is applied to find the contact force during impact. Some impact examples appearing in the literature are tested again in this study to evaluate the accuracy of the present partial mixed 3-D element in the impact dynamic analysis of laminated composite plates.

Liao, C.-L.; Tsai, J.-S.

1994-10-01

381

Model-Driven Safety Analysis of Closed-Loop Medical Systems  

PubMed Central

In modern hospitals, patients are treated using a wide array of medical devices that are increasingly interacting with each other over the network, thus offering a perfect example of a cyber-physical system. We study the safety of a medical device system for the physiologic closed-loop control of drug infusion. The main contribution of the paper is the verification approach for the safety properties of closed-loop medical device systems. We demonstrate, using a case study, that the approach can be applied to a system of clinical importance. Our method combines simulation-based analysis of a detailed model of the system that contains continuous patient dynamics with model checking of a more abstract timed automata model. We show that the relationship between the two models preserves the crucial aspect of the timing behavior that ensures the conservativeness of the safety analysis. We also describe system design that can provide open-loop safety under network failure.

Pajic, Miroslav; Mangharam, Rahul; Sokolsky, Oleg; Arney, David; Goldman, Julian; Lee, Insup

2013-01-01

382

A meta-analysis on the impacts of partial cutting on forest structure and carbon storage  

NASA Astrophysics Data System (ADS)

Partial cutting, which removes some individual trees from a forest, is one of the major and widespread forest management practices that can significantly alter both forest structure and carbon (C) storage. Using 746 observations from 82 publications, we synthesized the impacts of partial cutting on three variables associated with forest structure (i.e. mean annual growth of diameter at breast height (DBH), basal area (BA), and volume) and four variables related to various C stock components (i.e. aboveground biomass C (AGBC), understory C, forest floor C, and mineral soil C). Results shows that the growth of DBH elevated by 112% after partial cutting, compared to the uncut control, while stand BA and volume reduced immediately by 34% and 29%, respectively. On average, partial cutting reduced AGBC by 43%, increased understory C storage by 392%, but did not show significant effects on C storages on forest floor and in mineral soil. All the effects on DBH growth, stand BA, volume, and AGBC intensified linearly with cutting intensity (CI) and decreased linearly with the number of recovery years (RY). In addition to the strong impacts of CI and RY, other factors such as climate zone and forest type also affected forest responses to partial cutting. The data assembled in this synthesis were not sufficient to determine how long it would take for a complete recovery after cutting because long-term experiments were rare. Future efforts should be tailored to increase the duration of the experiments and balance geographic locations of field studies.

Zhou, D.; Zhao, S. Q.; Liu, S.; Oeding, J.

2013-01-01

383

Review of Overall Safety Manual for space nuclear systems. An evaluation of a nuclear safety analysis methodology for plutonium-fueled space nuclear systems  

SciTech Connect

As part of its duties in connection with space missions involving nuclear power sources, the Office of Nuclear Safety (ONS) of the Office of Assistant Secretary for Environmental Protection, Safety, and Emergency Preparedness has been assigned the task of reviewing the Overall Safety Manual (OSM) (memo from B.J. Rock to J.R. Maher, December 1, 1982). The OSM, dated July 1981 and in four volumes, was prepared by NUS Corporation, Rockville, Maryland, for the US Department of Energy. The OSM provides many of the technical models and much of the data which are used by (1) space launch contractors in safety analysis reports and (2) the broader Interagency Nuclear Safety Review Panel (INSRP) safety evaluation reports. If fhs interaction between the OSM, contractors, and INSRP is to work effectively, the OSM must be accurate, comprehensive, understandable, and usable.

Coleman, J.; Inhaber, H.

1984-02-01

384

Applications of singular value analysis and partial-step algorithm for nonlinear orbit determination  

NASA Astrophysics Data System (ADS)

An adaptive method in which cruise and nonlinear orbit determination problems can be solved using a single program is presented. It involves singular value decomposition augmented with an extended partial step algorithm. The extended partial step algorithm constrains the size of the correction to the spacecraft state and other solve-for parameters. The correction is controlled by an a priori covariance and a user-supplied bounds parameter. The extended partial step method is an extension of the update portion of the singular value decomposition algorithm. It thus preserves the numerical stability of the singular value decomposition method, while extending the region over which it converges. In linear cases, this method reduces to the singular value decomposition algorithm with the full rank solution. Two examples are presented to illustrate the method's utility.

Ryne, Mark S.; Wang, Tseng-Chan

385

Guidance on the implementation and reporting of a drug safety Bayesian network meta-analysis.  

PubMed

The Drug Information Association Bayesian Scientific Working Group (BSWG) was formed in 2011 with a vision to ensure that Bayesian methods are well understood and broadly utilized for design and analysis and throughout the medical product development process, and to improve industrial, regulatory, and economic decision making. The group, composed of individuals from academia, industry, and regulatory, has as its mission to facilitate the appropriate use and contribute to the progress of Bayesian methodology. In this paper, the safety sub-team of the BSWG explores the use of Bayesian methods when applied to drug safety meta-analysis and network meta-analysis. Guidance is presented on the conduct and reporting of such analyses. We also discuss different structural model assumptions and provide discussion on prior specification. The work is illustrated through a case study involving a network meta-analysis related to the cardiovascular safety of non-steroidal anti-inflammatory drugs. PMID:24038897

Ohlssen, David; Price, Karen L; Xia, H Amy; Hong, Hwanhee; Kerman, Jouni; Fu, Haoda; Quartey, George; Heilmann, Cory R; Ma, Haijun; Carlin, Bradley P

2014-01-01

386

"Multi-layer" one-dimensional model for stability analysis on partially detached divertor plasmas  

NASA Astrophysics Data System (ADS)

We propose a "multi-layer (ML)" 1D model for understanding behaviors of partially detached divertor plasmas. The basic idea is to analyze interaction among the adjacent flux tubes for the attached and detached states in the divertor region. Cross-field transport terms in both SOL and divertor regions are considered in this model. We show some preliminary simulations which indicate necessity of the ML 1D model. According to the simulations, cross-field energy flow in the divertor region can affect stability of a detachment front of partially detached plasmas, i.e. such flow can decrease the front speed towards the X point.

Nakamura, Makoto; Ogawa, Yuichi; Shinji, Naoki; Hiwatari, Ryoji; Okano, Kunihiko

2011-08-01

387

Overheads, Safety Analysis and Engineering FY 1995 Site Support Program Plan WBS 6.3.5  

SciTech Connect

The Safety Analysis & Engineering (SA&E) department provides core competency for safety analysis and risk documentation that supports achievement of the goals and mission as described in the Hanford Mission Plan, Volume I, Site Guidance (DOE-RL 1993). SA&E operations are integrated into the programs that plan and conduct safe waste management, environmental restoration, and operational activities. SA&E personnel are key members of task teams assigned to eliminate urgent risks and inherent threats that exist at the Hanford Site. Key to ensuring protection of public health and safety, and that of onsite workers, are the products and services provided by the department. SA&E will continue to provide a leadership role throughout the DOE complex with innovative, cost-effective approaches to ensuring safety during environmental cleanup operations. The SA&E mission is to provide support to direct program operations through safety analysis and risk documentation and to maintain an infrastructure responsive to the evolutionary climate at the Hanford Site. SA&E will maintain the appropriate skills mix necessary to fulfill the customers need to conduct all operations in a safe and cost-effective manner while ensuring the safety of the public and the onsite worker.

DiVincenzo, E.P.

1994-09-27

388

Use of cost\\/benefit analysis in determining environmental, safety, and health regulation  

Microsoft Academic Search

This study investigates the usefulness of cost\\/benefit analysis at determining environmental, health, and safety regulation. Cost\\/benefit analysis is used to assist in various areas of regulatory decision-making. The analysis is designed so that policy makers can choose the regulatory alternative that maximizes social welfare. In practice, the assumptions and simplifications associated with cost\\/benefit analysis cause it to be limited in

Paik

1983-01-01

389

Review and Analysis of Development of "Safety by Design" Requirements  

SciTech Connect

This report, the deliverable for Task 4 of the NA-243 Safeguards by Design Work Plan for Fiscal Year 2009, develops the lessons to be learned for the institutionalization of Safeguards By Design (SBD) from the Department of Energy (DOE) experience developing and implementing DOE-STD-1189, Integration of Safety into the Design Process. This experience was selected for study because of the similarity of the challenges of integrating safety and safeguards into the design process. Development of DOE-STD-1189 began in January 2006 and the standard was issued for implementation in March 2008. The process was much more time consuming than originally anticipated and might not have come to fruition had senior DOE management been less committed to its success. Potentially valuable lessons can be learned from both the content and presentation of the integration approach in DOE-STD-1189 and from the DOE experience in developing and implementing DOE-STD-1189. These lessons are important because the instutionalization of SBD does not yet appear to have the level of senior management commitment afforded development and implementation of DOE-STD-1189.

Vance, Scott A.; Hockert, John

2009-10-20

390

Benefit-Cost Analysis in Environmental, Health, and Safety Regulation: A Statement of Principles  

Microsoft Academic Search

Benefit-cost analysis can play a very important role in legislative and regulatory policy debates on improving the environment, health, and safety. It can help illustrate the tradeoffs that are inherent in public policymaking as well as make those tradeoffs more transparent. It can also help agencies set regulatory priorities. Benefit-cost analysis should be used to help decisionmakers reach a decision.

Kenneth J. Arrow; Maureen L. Cropper; George C. Eads; Robert W. Hahn; Lester B. Lave; Roger G. Noll; Paul R. Portney; Milton Russell; Richard L. Schmalensee; V. Kerry Smith; Robert N. Stavins

1996-01-01

391

Utilizing data envelopment analysis to benchmark safety performance of construction contractors  

Microsoft Academic Search

The purpose of this paper is to utilize data envelopment analysis (DEA) to benchmark safety performance of construction contractors. DEA has been recognized as a robust tool that is used for evaluating the performance of business organizations. The proposed approach is deployed based on empirical data collected from 45 construction contractors. On a scale of 0–1.0, DEA analysis assesses the

Mohammad S. El-Mashaleh; Shaher M. Rababeh; Khalied H. Hyari

2010-01-01

392

Combining functional and structural reasoning for safety analysis of electrical designs  

Microsoft Academic Search

Increasing complexity of design in automotive electrical systems has been paralleled by increased demands for analysis of the safety and reliability aspects of those designs. Such demands can place a great burden on the engineers charged with carrying out the analysis. This paper describes how the intended functions of a circuit design can be combined with a qualitative model of

M. S. W ILSON

393

Combining functional and structural reasoning for safety analysis of electrical designs  

Microsoft Academic Search

Increasing complexity of design in automotive electrical systems has been paralleled by increased demands for analysis of the safety and reliability aspects of those designs. Such demands can place a great burden on the engineers charged with carrying out the analysis. This paper describes how the intended functions of a circuit design can be combined with a qualitative model of

C. J. PRICE; J. E. HUNT; M. S. WILSON

1997-01-01

394

Linking Socioeconomic Status to Social Cognitive Career Theory Factors: A Partial Least Squares Path Modeling Analysis  

ERIC Educational Resources Information Center

The purpose of this study was to investigate the contributions of socioeconomic status (SES) in predicting social cognitive career theory (SCCT) factors. Data were collected from 738 college students in Taiwan. The results of the partial least squares (PLS) analyses indicated that SES significantly predicted career decision self-efficacy (CDSE);…

Huang, Jie-Tsuen; Hsieh, Hui-Hsien

2011-01-01

395

A posteriori analysis of finite element discretizations of stochastic partial differential delay equations  

Microsoft Academic Search

In this paper, we study a posteriori error estimates for finite element approximation of stochastic partial differential delay equations containing a noise. We derive an energy norm a posteriori bounds for an Euler time-stepping method combined with a standard Galerkin schemes for the problems. For accessibility, we first address the spatially semidiscrete case and then move to the fully discrete

Xiaoyuan Yang; Ruisheng Qi; Yuanyuan Duan

2011-01-01

396

Partial least squares, Beer's law and the net analyte signal: statistical modeling and analysis  

Microsoft Academic Search

Partial least squares (PLS) is one of the most common regression algorithms in chemistry, relating input-output samples (xi, yi) by a linear multivariate model. In this paper we analyze the PLS algorithm under a specific probabilistic model for the relation between x and y. Following Beer's law, we assume a linear mixture model in which each data sample (x, y)

Boaz Nadler; Ronald R. Coifman

2005-01-01

397

Use of spectral analysis and phase resolved partial discharge measurements for generator testing  

Microsoft Academic Search

A water cooled 291.5 MVA steam turbine generator was monitored online for partial discharge activity by means of electromagnetic interference measurements (EMI). The results presented an increase of activity by a factor of 10 in the frequency ranges 10 to 60 kHz and 30 to 50 MHz over 7 months of operation. After this period the generator was taken out

E. Hudon; C. W. Reed; J. E. Timperley

1994-01-01

398

Analysis of weekly complete blood counts in patients receiving standard fractionated partial body radiation therapy  

Microsoft Academic Search

Purpose: Hematopoiesis is among the most sensitive systems in the body to radiation. Routine complete blood counts (CBCs) are common in clinical radiotherapy practice. Only a few studies have attempted to characterize the behavior of peripheral blood levels during partial body radiation therapy with field sizes smaller than those used in hemibody or total nodal irradiation. Such information is needed

Farley E. Yang; Florin Vaida; Lani Ignacio; Alan Houghton; Jaishanker Nautiyal; Howard Halpern; Harold Sutton; Srinivasan Vijayakumar

1995-01-01

399

Parent Ratings of ADHD Symptoms: Generalized Partial Credit Model Analysis of Differential Item Functioning across Gender  

ERIC Educational Resources Information Center

Objective: Generalized partial credit model, which is based on item response theory (IRT), was used to test differential item functioning (DIF) for the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.), inattention (IA), and hyperactivity/impulsivity (HI) symptoms across boys and girls. Method: To accomplish this, parents completed…

Gomez, Rapson

2012-01-01

400

The Development and Performance Analysis of Partially Premixed LPG Porous Medium Combustor  

Microsoft Academic Search

Porous medium combustion has interesting advantages compared with free flame combustion due to higher burning rates, an increased power dynamic range, extension of the lean flammability limits, and low emissions of pollutants. This article presents the development and testing of a partially premixed porous medium combustor with liquified petroleum gas as fuel. The discrete porous medium is made up of

R. M. N. Muhad; M. Z. Abdullah; M. Abdul Mujeebu; M. Z. Abu Bakar; R. Zakaria; A. A. Mohamad

2011-01-01

401

Partial Dictation as a Measure of EFL Listening Proficiency: Evidence from Confirmatory Factor Analysis  

ERIC Educational Resources Information Center

Partial dictation is a measure of EFL listening proficiency that can be easily constructed, administered, and scored by EFL teachers. However, it is controversial whether this form of test measures lower-order abilities exclusively or involves both lower- and higher-order abilities. In order to answer this question, a study was designed to examine…

Cai, Hongwen

2013-01-01

402

Knowledge Management System Adoption and Practice in Taiwan Life Insurance Industry: Analysis via Partial Least Squares  

Microsoft Academic Search

This study examines the factors affecting the adoption and practice of knowledge management system (KMS) in Taiwan life insurance industry, using a mixed methodology approach. The research was carried out in three phases: field study, pilot survey and main survey. The main survey data were analyzed through Partial Least Squares (PLS) technique. The results indicate that the external factors affect

Li-Su Huang; Mohammed Quaddus

2007-01-01

403

Statistical analysis and segmentation of multi-look SAR imagery using partial polarimetric data  

Microsoft Academic Search

For terrain type classifications, when full polarimetric SAR data are not available, or when only selected discriminants are used, this paper presents customized maximum likelihood classification algorithms based on the probability density functions specifically developed for each case. It is found that in some cases, the use of partial information has actually improved the classification accuracy for some classes. The

J. S. Lee; L. Du; D. L. Schuler; M. R. Grunes

1995-01-01

404

Reply to ``Comment on `Pion-nucleon partial-wave analysis to 2 GeV' ''  

NASA Astrophysics Data System (ADS)

We have analyzed elastic pion-nucleon scattering data to approximately 2 GeV, extracting partial-wave amplitudes, resonance information, and the pion-nucleon coupling constant. Dowell and Rebka have noticed an error in our low-energy charge-exchange cross sections. We consider the effect of this error on the above-mentioned quantities.

Arndt, Richard A.; Strakovsky, Igor I.; Workman, Ron L.

1995-11-01

405

Pregabalin versus gabapentin in partial epilepsy: a meta-analysis of dose-response relationships  

Microsoft Academic Search

BACKGROUND: To compare the efficacy of pregabalin and gabapentin at comparable effective dose levels in patients with refractory partial epilepsy. METHODS: Eight randomized placebo controlled trials investigating the efficacy of pregabalin (4 studies) and gabapentin (4 studies) over 12 weeks were identified with a systematic literature search. The endpoints of interest were \\

Philippa Delahoy; Sally Thompson; Ian C Marschner

2010-01-01

406

A statistical fracture mechanics analysis of time-dependent strength behaviour of partially stabilized zirconia  

Microsoft Academic Search

The time-dependent strength behaviour of a partially stabilized zirconia ceramic (Mg-PSZ) when subjected to constant static and cyclic stresses as well as constant stress rates is analysed in terms of a statistical fracture mechanics model given earlier by the authors. Given the lifetimes for either constant static stresses or constant stress rates it is possible to estimate the lifetimes for

Kai Duan; Yiu-Wing Mai; Brian Cotterell

1988-01-01

407

Sparse multivariate autoregressive (mAR)-based partial directed coherence (PDC) for electroencephalogram (EEG) analysis  

Microsoft Academic Search

Partial directed coherence (PDC) has recently been proposed for studying brain connectivity in EEG studies. PDC provides a quantitative spectral measure of the causal relations between signals by its central use of a multivariate autoregressive (mAR) model. Yet, in real applications, the successful estimation of PDC depends on the accuracy of mAR parameter estimation, which is often sensitive to the

Joyce Chiang; Z. Jane Wang; Martin J. McKeown

2009-01-01

408

Oral Contribution: Partial wave analysis of J/? ? pbar p?0 and measurement of J/? ? pbar p?, pbar p??  

NASA Astrophysics Data System (ADS)

Based on 58 million J/? data collected with the BES II detector at the BEPC, Partial Wave Analysis(PWA) is performed on J/? ? pbar p?0. The new excited baryon N(2065) is confirmed. Clear signals for other N* states are observed and the corresponding masses, widths and spin-parity are also measured. Processes such as J/? ? pbar p?, pbar p?? are also studied and the branching ratios are measured.

Yang, Hong-Xun; BES Collaboration II

2009-12-01

409

Effects of relay chatter in seismic probabilistic safety analysis  

SciTech Connect

In the Zion and Indian Point Probabilistic Safety Studies, relay chatter was dismissed as a credible event and hence was not formally included in the analyses. Although little discussion is given in the Zion and Indian Point PSA documentation concerning the basis for this decision, it has been expressed informally that it was assumed that the operators will be able to reset all relays in a timely manner. Currently, it is the opinion of many professionals that this may be an oversimplification. The three basic areas which must be considered in addressing relay chatter include the fragility of the relays per se, the reliability of the operators to reset the relays and finally the systems response aspects. Each of these areas is reviewed and the implications for seismic PSA are discussed. Finally, recommendations for future research are given.

Reed, J.W.; Shiu, K.K.

1985-01-01

410

LESSONS LEARNED IN DEVELOPMENT OF THE HANFORD SWOC MASTER DOCUMENTED SAFETY ANALYSIS (MDSA) & IMPLEMENTATION VALIDATION REVIEW (IVR)  

SciTech Connect

DOE set clear expectations on a cost-effective approach for achieving compliance with the Nuclear Safety Management requirements (20 CFR 830, Nuclear Safety Rule), which ensured long-term benefit to Hanford, via issuance of a nuclear safety strategy in February 2003. To facilitate implementation of these expectations, tools were developed to streamline and standardize safety analysis and safety document development with the goal of a shorter and more predictable DOE approval cycle. A Hanford Safety Analysis and Risk Assessment Handbook (SARAH) was approved to standardize methodologies for development of safety analyses. A Microsoft Excel spreadsheet (RADIDOSE) was approved for the evaluation of radiological consequences for accident scenarios often postulated at Hanford. Standard safety management program chapters were approved for use as a means of compliance with the programmatic chapters of DOE-STD-3009, ''Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports''. An in-process review was developed between DOE and the Contractor to facilitate DOE approval and provide early course correction. The new Documented Safety Analysis (DSA) developed to address the operations of four facilities within the Solid Waste Operations Complex (SWOC) necessitated development of an Implementation Validation Review (IVR) process. The IVR process encompasses the following objectives: safety basis controls and requirements are adequately incorporated into appropriate facility documents and work instructions, facility personnel are knowledgeable of controls and requirements, and the DSA/TSR controls have been implemented. Based on DOE direction and safety analysis tools, four waste management nuclear facilities were integrated into one safety basis document. With successful completion of implementation of this safety document, lessons-learned from the in-process review, safety analysis tools and IVR process were documented for future action and consideration at other DOE sites.

MORENO, M.R.

2004-04-02

411

Analysis of partial and total flow blockage of a single fuel assembly of an MTR research reactor core  

Microsoft Academic Search

The main aim of the following study is to perform a safety analysis of the IAEA 10 MW MTR Pool type Research Reactor [IAEA-TECDOC-233, 1980. IAEA Research Reactor Core Conversion from the use of high-enriched uranium to the use of low enriched uranium fuels Guidebook] under flow blockage of a single Fuel Assembly (FA) conditions. Such event was rarely investigated

Martina Adorni; Anis Bousbia-Salah; Tewfik Hamidouche; Beniamino Di Maro; Franco Pierro; Francesco D’Auria

2005-01-01

412

Scope on Safety: NSTA's portal into the safety zone  

NSDL National Science Digital Library

NSTA's Science Safety Advisory Board recently launched the Safety in the Science Classroom portal, which contains safety resources for teachers, supervisors, and administrators. This month's column provides a partial listing of the resources middle schoo

Roy, Ken

2010-07-01

413

Station Blackout: A case study in the interaction of mechanistic and probabilistic safety analysis  

SciTech Connect

The ability to better characterize and quantify safety margins is important to improved decision making about nuclear power plant design, operation, and plant life extension. As research and development (R&D) in the light-water reactor (LWR) Sustainability (LWRS) Program and other collaborative efforts yield new data, sensors, and improved scientific understanding of physical processes that govern the aging and degradation of plant SSCs needs and opportunities to better optimize plant safety and performance will become known. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway R&D is to support plant decisions for risk-informed margin management with the aim to improve economics, reliability, and sustain safety of current NPPs. In this paper, we describe the RISMC analysis process illustrating how mechanistic and probabilistic approaches are combined in order to estimate a safety margin. We use the scenario of a “station blackout” wherein offsite power and onsite power is lost, thereby causing a challenge to plant safety systems. We describe the RISMC approach, illustrate the station blackout modeling, and contrast this with traditional risk analysis modeling for this type of accident scenario.

Curtis Smith; Diego Mandelli; Cristian Rabiti

2013-11-01

414

Preliminary Results Obtained in Integrated Safety Analysis of NASA Aviation Safety Program Technologies  

NASA Technical Reports Server (NTRS)

This is a listing of recent unclassified RTO technical publications processed by the NASA Center for AeroSpace Information from January 1, 2001 through March 31, 2001 available on the NASA Aeronautics and Space Database. Contents include 1) Cognitive Task Analysis; 2) RTO Educational Notes; 3) The Capability of Virtual Reality to Meet Military Requirements; 4) Aging Engines, Avionics, Subsystems and Helicopters; 5) RTO Meeting Proceedings; 6) RTO Technical Reports; 7) Low Grazing Angle Clutter...; 8) Verification and Validation Data for Computational Unsteady Aerodynamics; 9) Space Observation Technology; 10) The Human Factor in System Reliability...; 11) Flight Control Design...; 12) Commercial Off-the-Shelf Products in Defense Applications.

2001-01-01

415

PWR integrated safety analysis methodology using multi-level coupling algorithm  

NASA Astrophysics Data System (ADS)

Coupled three-dimensional (3D) neutronics/thermal-hydraulic (T-H) system codes give a unique opportunity for a realistic modeling of the plant transients and design basis accidents (DBA) occurring in light water reactors (LWR). Examples of such DBAs are the rod ejection accidents (REA) and the main steam line break (MSLB) that constitute the bounding safety problems for pressurized water reactors (PWR). These accidents involve asymmetric 3D spatial neutronic and T-H effects during the course of the transients. The thermal margins (the peak fuel temperature, and departure from nucleate boiling ratio (DNBR)) are the measures of safety at a particular transient and need to be evaluated as accurate as possible. Modern 3D neutronics/T-H coupled codes estimate the safety margins coarsely on an assembly level, i.e. for an average fuel pin. More accurate prediction of the safety margins requires the evaluation of the transient fuel rod response involving locally coupled neutronics/T-H calculations. The proposed approach is to perform an on-line hot-channel safety analysis not for the whole core but for a selected local region, for example for the highest power loaded fuel assembly. This approach becomes feasible if an on-line algorithm capable to extract the necessary input data for a sub-channel module is available. The necessary input data include the detailed pin-power distributions and the T-H boundary conditions for each sub-channel in the considered problem. Therefore, two potential challenges are faced in the development of refined methodology for evaluation of local safety parameters. One is the development of an efficient transient pin-power reconstruction algorithm with a consistent cross-section modeling. The second is the development of a multi-level coupling algorithm for the T-H boundary and feed-back data exchange between the sub-channel module and the main 3D neutron kinetics/T-H system code, which already uses one level of coupling scheme between 3D neutronics and core thermal-hydraulics models. The major accomplishment of the thesis is the development of an integrated PWR safety analysis methodology with locally refined safety evaluations. This involved introduction of an improved method capable of efficiently restoring the fine pin-power distribution with a high degree of accuracy. In order to apply the methodology to evaluate the safety margins on a pin level, a refined on-line hot channel model was developed accounting for the cross-flow effects. Finally, this methodology was applied to best estimate safety analysis to more accurately calculate the thermal safety margins occurring during a design basis accident in PWR.

Ziabletsev, Dmitri Nickolaevich

416

Safety Analysis (SA) of the decontamination facility, Building 419, at the Lawrence Livermore National Laboratory  

SciTech Connect

This safety analysis was performed for the Manager, Plant Services at LLNL and fulfills the requirements of DOE Order 5481.1. The analysis was based on field inspections, document review, computer calculations, and extensive input from Waste Management personnel. It was concluded that the maximum quantities of radioactive materials that safety procedures allow to be handled in this building do not pose undue risks on- or off-site even in postulated severe accidents. Risk from the various hazards at this facility vary from low to moderate as specified in DOE Order 5481.1. Recommendations are made for improvements that will reduce risks even further.

Odell, B.N.

1980-06-17

417

Methodology for the relative risk assessment in the NIF Preliminary Safety Analysis Report  

SciTech Connect

This document provides the methodology used for the relative risk assessment performed in the NIF Preliminary Safety Analysis Report. The safety analysis for a facility of the hazard level of NIF (low hazard, radiological) should be mostly qualitative. This was the approach taken for the NIF risk assessment, where qualitative descriptors were assigned to event consequences and frequencies. The event consequences and frequencies were then combined using a risk matrix to obtain an assessment of the relative risk presented by each event to NIF workers and to the public. The development of the risk matrices is the main subject of this report. The matrices have been applied in the NIF PSAR (LLNL, 1996).

Brereton, S.J.

1996-08-01

418

Renormalization shielding and eikonal analysis on the atomic collision in dense partially ionized hydrogen plasmas  

SciTech Connect

The renormalization plasma screening effects on the electron-ion collision are investigated in dense partially ionized hydrogen plasmas. The Hamilton-Jacobi and eikonal methods with the effective interaction potential are employed to obtain the eikonal scattering phase shift and eikonal cross section for the electron-ion collision. It is found that the influence of renormalization screening strongly suppresses the eikonal scattering phase shift as well as the eikonal cross section, especially, for small impact parameter regions. In addition, the renormalization screening effect reduces the total eikonal cross section in all energy domains. The variation of the renormalization effects on the electron-ion collision in dense partially ionized hydrogen plasmas is also discussed.

Kim, Sung Soo [Department of Applied Mathematics, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of)] [Department of Applied Mathematics, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of); Jung, Young-Dae [Department of Applied Physics and Department of Bionanotechnology, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of) [Department of Applied Physics and Department of Bionanotechnology, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of); Department of Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, New York 12180-3590 (United States)

2013-12-15

419

Renormalization shielding and eikonal analysis on the atomic collision in dense partially ionized hydrogen plasmas  

NASA Astrophysics Data System (ADS)

The renormalization plasma screening effects on the electron-ion collision are investigated in dense partially ionized hydrogen plasmas. The Hamilton-Jacobi and eikonal methods with the effective interaction potential are employed to obtain the eikonal scattering phase shift and eikonal cross section for the electron-ion collision. It is found that the influence of renormalization screening strongly suppresses the eikonal scattering phase shift as well as the eikonal cross section, especially, for small impact parameter regions. In addition, the renormalization screening effect reduces the total eikonal cross section in all energy domains. The variation of the renormalization effects on the electron-ion collision in dense partially ionized hydrogen plasmas is also discussed.

Kim, Sung Soo; Jung, Young-Dae

2013-12-01

420

Element-free Galerkin (EFG) method for analysis of the time-fractional partial differential equations  

NASA Astrophysics Data System (ADS)

The present paper deals with the numerical solution of time-fractional partial differential equations using the element-free Galerkin (EFG) method, which is based on the moving least-square approximation. Compared with numerical methods based on meshes, the EFG method for time-fractional partial differential equations needs only scattered nodes instead of meshing the domain of the problem. It neither requires element connectivity nor suffers much degradation in accuracy when nodal arrangements are very irregular. In this method, the first-order time derivative is replaced by the Caputo fractional derivative of order ? (0 < ? < 1). The Galerkin weak form is used to obtain the discrete equations, and the essential boundary conditions are enforced by the penalty method. Several numerical examples are presented and the results we obtained are in good agreement with the exact solutions.

Ge, Hong-Xia; Liu, Yong-Qing; Cheng, Rong-Jun

2012-01-01

421

Functional and structural analysis of partial optic nerve avulsion due to blunt trauma: Case report  

PubMed Central

Partial optic nerve avulsion (ONA) secondary to finger gouging is an uncommon but devastating injury. A 21-year-old man who had an acute vision loss after accidentally getting poked by himself in his right eye when he fell down during jogging is reported. The patient was diagnosed with partial ONA. Magnetic resonance imaging revealed intact optic nerve. Optical coherence tomography (OCT) revealed deep cavity at the inferior-temporal half of the optic disc. Retinal nerve fiber layer thickness was also thin at the inferior quadrant with circumpapillary OCT scan. Visual field test and electrophysiological tests showed functional abnormality compatible with optic nerve lesion. Diagnostic tools for anatomical and functional evaluation may reveal the course of this injury.

Mumcuoglu, Tarkan; Durukan, Hakan A; Erdurman, Cuneyt; Hurmeric, Volkan; Gundogan, Fatih C

2010-01-01

422

System safety education focused on flight safety  

NASA Technical Reports Server (NTRS)

The measures necessary for achieving higher levels of system safety are analyzed with an eye toward maintaining the combat capability of the Air Force. Several education courses were provided for personnel involved in safety management. Data include: (1) Flight Safety Officer Course, (2) Advanced Safety Program Management, (3) Fundamentals of System Safety, and (4) Quantitative Methods of Safety Analysis.

Holt, E.

1971-01-01

423

Spatiotemporal analysis of event-related fMRI data using partial least squares  

Microsoft Academic Search

Partial least squares (PLS) has proven to be a important multivariate analytic tool for positron emission tomographic and, more recently, event-related potential (ERP) data. The application to ERP incorporates the ability to analyze space and time together, a feature that has obvious appeal for event-related functional magnetic resonance imaging (fMRI) data. This paper presents the extension of spatiotemporal PLS (ST-PLS)

A. R. McIntosh; W. K. Chau; A. B. Protzner

2004-01-01

424

Atomistic simulations and Peierls–Nabarro analysis of the Shockley partial dislocations in palladium  

Microsoft Academic Search

A detailed study of Shockley partials in Pd is presented, using a full-scale atomistic simulation of the structure and energetics of the dislocation motion. The interatomic potential is derived by fitting to data from first-principles electron-structure calculations. The outcome from the atomistic simulation is compared with the corresponding results using the Peierls–Nabarro (PN) model. The required input to the PN

Björn von Sydow; Jan Hartford; Göran Wahnström

1999-01-01

425

Analysis of Partially Methyl-Esterified Galacturonic Acid Oligomers by Capillary Electrophoresis  

Microsoft Academic Search

Recent progress in the determination of the intramolecular distribution of methyl-esterified residues in pectic substrates has been made using a fragmentation approach in which endopolygalacturonase is used to digest the polysaccharide and its subsequent (methyl-ester sequence-dependent) digest pattern is determined. This has been facilitated by the separation of partially methyl-esterified enzyme digest fragments using high-performance anion-exchange chromatography at pH 5.

Martin A. K. Williams; Gaëlle M. C. Buffet; Tim J. Foster

2002-01-01

426

Partial nitrification and oxygen transfer analysis utilizing hollow fiber membrane aeration  

Microsoft Academic Search

Excess nutrients in lakes, rivers, and streams harm aquatic ecosystems.y Advanced treatment at wastewater treatment plants can reduce this pollutant load.y An innovative nutrient removal system, ANAMMOX, anaerobically converts ammonium and nitrite to N2 gas.y Because this system requires a 1:1.31 NH4+ : NO2– ratio, a partial nitrification system is coupled with the ANAMMOX system to provide the necessary substrates.y

Samuel Wesley Cotter

2010-01-01

427

Analysis of partial dislocations in wurtzite GaN using gradient elasticity  

Microsoft Academic Search

A non-singular gradient elasticity solution for the dislocation self-energy is employed and compared to previous results for 1\\/6203 partial dislocations fault in wurtzite GaN obtained by empirical potential calculations. Twenty-four previously obtained stable dislocation cores, twelve for each GaN polarity, are considered. It is shown that the gradient elasticity solution can be fitted to the atomistic simulations with good agreement

J. Kioseoglou; G. P. Dimitrakopulos; Ph. Komninou; Th. Karakostas; I. Konstantopoulos; M. Avlonitis; E. C. Aifantis

2006-01-01

428

Analysis of swallowing after partial frontolateral laryngectomy with epiglottic reconstruction for glottic cancer.  

PubMed

The aim of the study was to evaluate swallowing using a reproducible objective methodology and to seek preoperative factors that could influence swallowing outcomes in patients operated on for partial laryngectomy. Twenty-four patients who underwent partial frontolateral laryngectomy with epiglottic reconstruction for T1bN0 or T2N0 glottic carcinoma between 2008 and 2012 were retrospectively evaluated. Using fiberoptic endoscopic and videofluoroscopic evaluation, early (15 days postoperatively) and late (2 months postoperatively) scores were obtained for all patients to quantify their swallowing skills. Eighty-three percent of patients achieved at least partial oral feeding at time of hospital discharge and 87.5 % achieved exclusive oral feeding within 2 months postoperatively. Early score was good or excellent in 50 %, average in 4.2 % and poor in 41.8 %. Regarding late scores, 63 % were classified as having a good or excellent late score, 7 patients (29 %) were classified as "middle result" because their time to recover was longer (i.e. between 1 and 2 months postoperatively), and two patients had a poor late score. Finally, at last follow-up, only one patient was partially fed by gastrostomy (180 days after surgery). T stage (p = 0.04) was the only factor influencing early swallowing outcomes and length of hospital stay was longer for poor scores than for good late results (p = 0.02). Our findings show good outcomes in terms of postoperative swallowing. Objective assessment of deglutition is essential for a better understanding of the mechanisms of postoperative swallowing disorders and for patient selection. PMID:24100885

Fakhry, Nicolas; Michel, Justin; Giorgi, Roch; Robert, Danielle; Lagier, Aude; Santini, Laure; Moreddu, Eric; Puymerail, Laurent; Adalian, Pascal; Dessi, Patrick; Giovanni, Antoine

2014-07-01

429

A classification-driven partially occluded object segmentation (CPOOS) method with application to chromosome analysis  

Microsoft Academic Search

Classification of segment images created by connecting points of high concavity along curvatures is used to resolve partial occlusion in images. Modeling of shape or curvature is not necessary nor is the traditional excessive use of heuristics. Applied to human cell images, 82.6% of the analyzed clusters of chromosomes are correctly separated, rising to 90.5% following rejection of 8.7% of

Boaz Lerner; Hugo Guterman; I. Dinstein

1998-01-01

430

Absolute partial cross sections and kinetic energy analysis for the electron impact ionization of propene  

Microsoft Academic Search

We present absolute partial electron impact ionization cross sections for propene in the electron energy range between threshold and 1000eV measured with a two sector field double focussing mass spectrometer. Ion beam profiles have been measured at all electron energies by applying a deflection field method. In combination with a three-dimensional ion trajectory simulation of ions produced in the ion

S. Feil; A. Bacher; K. Gluch; S. Matt-Leubner; P. Scheier; T. D. Märk

2006-01-01

431

Stress and strain analysis of contractions during ramp distension in partially obstructed guinea pig jejunal segments  

PubMed Central

Previous studies have demonstrated morphological and biomechanical remodeling in the intestine proximal to an obstruction. The present study aimed to obtain stress and strain thresholds to initiate contraction and the maximal contraction stress and strain in partially obstructed guinea pig jejunal segments. Partial obstruction and sham operations were surgically created in mid-jejunum of male guinea pigs. The animals survived 2, 4, 7, and 14 days, respectively. Animals not being operated on served as normal controls. The segments were used for no-load state, zero-stress state and distension analyses. The segment was inflated to 10 cmH2O pressure in an organ bath containing 37°C Krebs solution and the outer diameter change was monitored. The stress and strain at the contraction threshold and at maximum contraction were computed from the diameter, pressure and the zero-stress state data. Young’s modulus was determined at the contraction threshold. The muscle layer thickness in obstructed intestinal segments increased up to 300%. Compared with sham-obstructed and normal groups, the contraction stress threshold, the maximum contraction stress and the Young’s modulus at the contraction threshold increased whereas the strain threshold and maximum contraction strain decreased after 7 days obstruction (P<0.05 and 0.01). In conclusion, in the partially obstructed intestinal segments, a larger distension force was needed to evoke contraction likely due to tissue remodeling. Higher contraction stresses were produced and the contraction deformation (strain) became smaller.

Zhao, Jingbo; Liao, Donghua; Yang, Jian; Gregersen, Hans

2011-01-01

432

Safety, tolerability and risk benefit analysis of tiotropium in COPD  

PubMed Central

COPD is a chronic disease and, like many other chronic diseases, there is no treatment to reverse the severity of the disease except for lung transplant. To date, no inhaled medications have been shown to improve survival. Tiotropium bromide is a long-acting inhaled anticholinergic drug for the treatment of COPD that can improve lung function, reduce symptoms and exacerbations, and improve quality of life with once-daily dosing. It was initially approved and marketed in several countries in Europe in 2002 and then approved in the US in 2004. Tiotropium is generally well tolerated with dry mouth being the main adverse effect. Other adverse effects include constipation, tachycardia, blurred vision, urinary retention and increased intraocular pressure. Despite the recently raised concerns about an excess risk of cardiovascular adverse events with inhaled anticholinergic agents, the risk/benefit ratio of tiotropium appears still favorable given the favorable safety profile demonstrated in the UPLIFT study. However, caution should be advised in patients at high risk for cardiovascular disease given the paucity of data in such patients.

Oba, Yuji; Zaza, Tareq; Thameem, Danish M

2008-01-01

433

Upgrade Uranium Recovery Project No. 34110: Final Safety Analysis Report.  

National Technical Information Service (NTIS)

The accident analysis of the upgrade uranium recovery system indicated three potential hazards: (1) criticality, (2) toxic fumes from nitric acid solutions, and (3) release of toxic uranyl nitrate solutions. Any of these are capable of causing the death o...

1981-01-01

434

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2010 CFR

...that the system satisfies the fault tolerance requirements of...that the system satisfies the fault tolerance requirements of section...Follow a standard industry methodology such as a fault tree analysis or a failure modes...

2010-01-01

435

14 CFR 417.309 - Flight safety system analysis.  

Code of Federal Regulations, 2010 CFR

...that the system satisfies the fault tolerance requirements of...that the system satisfies the fault tolerance requirements of section...Follow a standard industry methodology such as a fault tree analysis or a failure modes...

2009-01-01

436

Retigabine as adjunctive therapy in adults with partial-onset seizures: integrated analysis of three pivotal controlled trials.  

PubMed

We assessed the efficacy and tolerability of retigabine (RTG; international non-proprietary name)/ezogabine (EZG; US adopted name) as adjunctive therapy in adults with partial-onset seizures in an integrated analysis of three trials. Studies 205, 301 (NCT00232596), and 302 (NCT00235755) were randomized, double-blind, placebo-controlled studies in adults having ?4 partial-onset seizures per 28 days and receiving 1-3 antiepileptic drugs with/without vagus nerve stimulator. Patients underwent titration to RTG/EZG 600, 900, or 1200 mg/day or to placebo followed by 8 or 12 weeks maintenance. For efficacy analyses, placebo was compared with RTG/EZG 600 and 900 mg/day in Studies 205 and 302, and RTG/EZG 1200 mg/day in Studies 205 and 301. Responder rates (?50% reduction in baseline seizure frequency) were 35% and 45% for RTG/EZG 600 and 900 mg/day, respectively (placebo=21%; p<0.001), and 50% for RTG/EZG 1200 mg/day (placebo=24%, p<0.001). Reductions in 28-day total partial-seizure frequency (medians: placebo=14%; 600 mg/day=26%, p=0.003; 900 mg/day=37%, p<0.001; placebo=15%; 1200 mg/day=39%, p<0.001) were significantly greater with all RTG/EZG doses vs. placebo from baseline to the double-blind phase, and similarly during the maintenance phase. The most commonly reported (>10%) treatment-emergent adverse events were dizziness, somnolence, headache, and fatigue. RTG/EZG demonstrated efficacy and was generally tolerated as adjunctive therapy in adults with partial-onset seizures in this integrated analysis. PMID:22512894

Porter, Roger J; Burdette, David E; Gil-Nagel, Antonio; Hall, Susan T; White, Robin; Shaikh, Soraya; DeRossett, Sarah E

2012-08-01

437

Numerical analysis of partially molten splat during thermal spray process using the finite element method  

NASA Astrophysics Data System (ADS)

A finite element method is used to simulate the deposition of the thermal spray coating process. A set of governing equations is solving by a volume of fluid method. For the solidification phenomenon, we use the specific heat method (SHM). We begin by comparing the present model with experimental and numerical model available in the literature. In this study, completely molten or semi-molten aluminum particle impacts a H13 tool steel substrate is considered. Next we investigate the effect of inclination of impact of a partially molten particle on flat substrate. It was found that the melting state of the particle has great effects on the morphologies of the splat.

Zirari, M.; Abdellah El-Hadj, A.; Bacha, N.

2010-03-01

438

Adaptive Backstepping Control and Safety Analysis for Modern Fighter Aircraft  

Microsoft Academic Search

There exist many examples of aircraft incidents in which the pilots have successfully used the remaining control authority over an aircraft to save the airframe and its passengers and cargo from apparently hopeless failure conditions. Unfortunately, the opposite is also true. Several accidents happened in which the crew was not able to save the aircraft, although post-flight analysis showed that

E. R. Van Oort

2011-01-01

439

Stress analysis of portable safety platform (Core Sampler Truck)  

SciTech Connect

This document provides the stress analysis and evaluation of the portable platform of the rotary mode core sampler truck No. 2 (RMCST {number_sign}2). The platform comprises railing, posts, deck, legs, and a portable ladder; it is restrained from lateral motion by means of two brackets added to the drill-head service platform.

Ziada, H.H.

1995-03-30

440

Preliminary analysis of the safety and environmental impact of the Tritium Systems Test Assembly  

Microsoft Academic Search

The Tritium Systems Test Assembly (TSTA) is a facility dedicated to the development of technologies associated with the D-T fuel cycle of future fusion reactors while demonstrating that TSTA can be operated safely with no significant losses to the environment. During the initial design stage of TSTA, a safety analysis was performed which investigated the effects of major subsystem component

R. V. Carlson; R. A. Jalbert

1980-01-01

441

Safety analysis of high pressure 3He-filled micro-channels for thermal neutron detection  

Microsoft Academic Search

This document is a safety analysis of a novel neutron detection technology developed by Sandia National Laboratories. This technology is comprised of devices with tiny channels containing high pressure ³He. These devices are further integrated into large scale neutron sensors. Modeling and preliminary device testing indicates that the time required to detect the presence of special nuclear materials may be

Scott M. Ferko; Paul C. Galambos; Mark Steven Derzon; Ronald F. Renzi

2008-01-01

442

Comparative Analysis of Different Configurations of PLC-Based Safety Systems from Reliability Point of View.  

National Technical Information Service (NTIS)

The study of a comparative analysis of distinct multiplex and fault-tolerant configurations for a PLC-based safety system from a reliability point of view is presented. It considers simplex, duplex and fault-tolerant triple redundancy configurations. The ...

M. A. Tapia

1993-01-01

443

Decision analysis on fire safety design based on evaluating building fire risk to life  

Microsoft Academic Search

This study presents a framework of decision analysis on fire safety design alternatives based on evaluating building fire risk to life. A probabilistic risk assessment method for occupant life is presented with consideration of some uncertainties of evacuation process and fire development at first. For occupant evacuation time assessment, occupant pre-movement time is characterized by normal distribution. For onset time

Guanquan Chu; Jinhua Sun

2008-01-01

444

Safety Analysis of Process Industry System Based on Complex Networks Theory  

Microsoft Academic Search

In this paper, we introduce a new method for safety analysis of process industry systems based on recent advances in complex networks. We model the process industry system as a large, complex network and study its topological properties, and then we investigate the cascading failures by constructing a simple model incorporating the loads on nodes and the efficiency of network.

Hongquan Jiang; Jianmin Gao; Zhiyong Gao; Guo Li

2007-01-01

445

Sensitivity analysis on heterogeneity of driving behavior for evacuation studies and its impacts on traffic safety  

Microsoft Academic Search

The driving behavior of travelers has been found to be different in case of emergency conditions compared to normal traffic conditions. In this paper, we show how this different driving behavior, as well as the heterogeneity among drivers, has an impact on traffic safety. We do so by performing a sensitivity analysis on the model parameters representing the different (heterogeneous)

Huizhao Tu; Guus Tamminga; Adam J. Pel; Hans Drolenga

2010-01-01

446

The Range Safety Debris Catalog Analysis in Preparation for the Pad Abort One Flight Test  

NASA Technical Reports Server (NTRS)

With each flight test a Range Safety Data Package is assembled to understand the potential consequences of various failure scenarios. Debris catalog analysis considers an overpressure failure of the Abort Motor and the resulting debris field created 1. Characterize debris fragments generated by failure: weight, shape, and area 2. Compute fragment ballistic coefficients 3. Compute fragment ejection velocities.

Kutty, Prasad; Pratt, William

2010-01-01

447

Finite element analysis of impact damage response of composite motorcycle safety helmets  

Microsoft Academic Search

The energy absorption during impact provided by a motorcycle safety helmet is always of critical importance in order to protect the rider against head injury during an accident. In the present study, a parametric analysis has been performed in order to investigate the effect of the composite shell stiffness and the damage development during impact, on the dynamic response of

V Kostopoulos; Y. P Markopoulos; G Giannopoulos; D. E Vlachos

2002-01-01

448

Seismic probabilistic safety analysis of unit 1 of the Loviisa nuclear power plant  

Microsoft Academic Search

The seismic probabilistic safety assessment consists of five phases. In the seismic hazard analysis the seismicity of the plant site is quantified. In the second phase, the structural response of plant buildings is evaluated. On the basis of structural response, the seismic fragilities of selected plant components are developed. In the following phase, the plant l